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Search of human proteins with 23111036
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23111036 sorting nexin 1 isoform c [Homo sapiens]
(474 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23111036 sorting nexin 1 isoform c [Homo sapiens] 929 0.0
gi|23111034 sorting nexin 1 isoform a [Homo sapiens] 906 0.0
gi|23111032 sorting nexin 1 isoform b [Homo sapiens] 671 0.0
gi|23111038 sorting nexin 2 [Homo sapiens] 501 e-142
gi|194294540 sorting nexin 7 isoform a [Homo sapiens] 94 3e-19
gi|23111055 sorting nexin 7 isoform b [Homo sapiens] 94 4e-19
gi|23111047 sorting nexin 5 [Homo sapiens] 88 1e-17
gi|7657599 sorting nexin 5 [Homo sapiens] 88 1e-17
gi|153791707 sorting nexin family member 30 [Homo sapiens] 81 2e-15
gi|72534838 sorting nexin 6B [Homo sapiens] 80 3e-15
gi|23111030 sorting nexin 12 [Homo sapiens] 76 8e-14
gi|4507143 sorting nexin 3 isoform a [Homo sapiens] 72 8e-13
gi|88703041 sorting nexin 6 isoform b [Homo sapiens] 71 2e-12
gi|23111026 sorting nexin 11 [Homo sapiens] 65 2e-10
gi|23111028 sorting nexin 11 [Homo sapiens] 65 2e-10
gi|23397574 sorting nexin 33 [Homo sapiens] 57 4e-08
gi|68800430 HCLS1 binding protein 3 [Homo sapiens] 53 5e-07
gi|157502171 sorting nexin 19 [Homo sapiens] 53 5e-07
gi|23238244 sorting nexin 16 isoform a [Homo sapiens] 52 1e-06
gi|23238246 sorting nexin 16 isoform a [Homo sapiens] 52 1e-06
gi|157057545 sorting nexin 18 isoform a [Homo sapiens] 51 2e-06
gi|23111023 sorting nexin 10 [Homo sapiens] 50 4e-06
gi|224177511 sorting nexin 18 isoform c [Homo sapiens] 50 6e-06
gi|157057543 sorting nexin 18 isoform b [Homo sapiens] 50 6e-06
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 48 2e-05
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 48 2e-05
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 48 2e-05
gi|23943858 sorting nexin 8 [Homo sapiens] 45 1e-04
gi|7661890 sorting nexin 17 [Homo sapiens] 44 2e-04
gi|17864088 sorting nexin 13 [Homo sapiens] 43 5e-04
>gi|23111036 sorting nexin 1 isoform c [Homo sapiens]
Length = 474
Score = 929 bits (2400), Expect = 0.0
Identities = 474/474 (100%), Positives = 474/474 (100%)
Query: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
Sbjct: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
Query: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE
Sbjct: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
Query: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ
Sbjct: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
Query: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
Sbjct: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
Query: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
Query: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
Sbjct: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
Query: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRWESRVTQYERDFE 420
TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRWESRVTQYERDFE
Sbjct: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRWESRVTQYERDFE 420
Query: 421 RISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 474
RISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
Sbjct: 421 RISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 474
>gi|23111034 sorting nexin 1 isoform a [Homo sapiens]
Length = 522
Score = 906 bits (2341), Expect = 0.0
Identities = 474/522 (90%), Positives = 474/522 (90%), Gaps = 48/522 (9%)
Query: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
Sbjct: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
Query: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE
Sbjct: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
Query: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ
Sbjct: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
Query: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
Sbjct: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
Query: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
Query: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
Sbjct: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
Query: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVR------------- 407
TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVR
Sbjct: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW 420
Query: 408 -----------------------------------WESRVTQYERDFERISTVVRKEVIR 432
WESRVTQYERDFERISTVVRKEVIR
Sbjct: 421 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR 480
Query: 433 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 474
FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
Sbjct: 481 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 522
>gi|23111032 sorting nexin 1 isoform b [Homo sapiens]
Length = 457
Score = 671 bits (1732), Expect = 0.0
Identities = 376/522 (72%), Positives = 388/522 (74%), Gaps = 113/522 (21%)
Query: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEG
Sbjct: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEG----------------- 43
Query: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
+D+F A V +Q + +L+ +
Sbjct: 44 -------------------------EDIFTGAAV------VSKHQSPKITTSLLPI---- 68
Query: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
N SK +EE +++E +D F GDGMNAYVAYKVTTQTSLPLFRSKQ
Sbjct: 69 -NNGSKENGIHEE-QDQEPQDLF-----------AGDGMNAYVAYKVTTQTSLPLFRSKQ 115
Query: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
Sbjct: 116 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 175
Query: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
Sbjct: 176 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 235
Query: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
Sbjct: 236 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 295
Query: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVR------------- 407
TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVR
Sbjct: 296 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW 355
Query: 408 -----------------------------------WESRVTQYERDFERISTVVRKEVIR 432
WESRVTQYERDFERISTVVRKEVIR
Sbjct: 356 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR 415
Query: 433 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 474
FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
Sbjct: 416 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 457
>gi|23111038 sorting nexin 2 [Homo sapiens]
Length = 519
Score = 501 bits (1290), Expect = e-142
Identities = 285/532 (53%), Positives = 350/532 (65%), Gaps = 81/532 (15%)
Query: 10 ASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPKITTSLLPI- 68
A+ER PPP G +P + +GED+FT + + LP
Sbjct: 2 AAEREPPPL-----------GDGKPTDFEDLEDGEDLFTSTVSTLESSPSSPEPASLPAE 50
Query: 69 -----NNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQ----------KKVLAKTL 113
+NG K + + D+E DLFA+AT E+SLDS + V TL
Sbjct: 51 DISANSNGPKPTEVVLDDDRE--DLFAEATEEVSLDSPEREPILSSEPSPAVTPVTPTTL 108
Query: 114 ISLPPQEATNSSKP---QPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQ 170
I+ P E+ + S P + EE+EEE D FD+ +G++DPEK+GDGMNAY+AY+VTT+
Sbjct: 109 IA-PRIESKSMSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMNAYMAYRVTTK 167
Query: 171 TSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSS 230
TSL +F +F+VKRRFSDFLGL+ KL+ K+ G+IVPP PEKS++GMTKVKVGKEDSS
Sbjct: 168 TSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKVGKEDSS 227
Query: 231 SAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNK 290
S EF+EKRRAALERYLQR V HPT+LQDPD+R+FLE ELPRAV TQ LSGAG+L+M NK
Sbjct: 228 STEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSGAGILRMVNK 287
Query: 291 ATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKS 350
A DAV+KMTIKMNESD WFEEK Q+ E +Q+LRKLH VE LV HRKEL+ NTA FAKS
Sbjct: 288 AADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANTAAFAKS 347
Query: 351 LAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVR--- 407
AMLG+SED+TALSRALSQLAEVEEKI+QLHQEQA DF++ +ELLSDYIRL+A V+
Sbjct: 348 AAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIAAVKGVF 407
Query: 408 ---------------------------------------------WESRVTQYERDFERI 422
WE++V Q ERDFE+I
Sbjct: 408 DHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGERDFEQI 467
Query: 423 STVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 474
S +RKEV RFEKE+ KDFK +IKYLE+L+ +QQQL KYWEAFLPEAKAI+
Sbjct: 468 SKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAIA 519
>gi|194294540 sorting nexin 7 isoform a [Homo sapiens]
Length = 451
Score = 94.0 bits (232), Expect = 3e-19
Identities = 94/388 (24%), Positives = 164/388 (42%), Gaps = 73/388 (18%)
Query: 125 SKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVK 184
+ P +++ E++ D DL + + +PE + ++ Y++ T+TS F S +F V+
Sbjct: 76 TSPLSMINQIKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVR 135
Query: 185 RRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALER 244
RR+ DFL L KL E H I+PP PEK ++ G + + +F+E RR AL +
Sbjct: 136 RRYQDFLWLKGKLEEAHPT--LIIPPLPEKFIV------KGMVERFNDDFIETRRKALHK 187
Query: 245 YLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMT----- 299
+L RI +HPT+ + D + FL + + + G GLL + AV+
Sbjct: 188 FLNRIADHPTLTFNEDFKIFLTAQAW--ELSSHKKQGPGLLSRMGQTVRAVASSMRGVKN 245
Query: 300 -----IKMNESDIWFEEKLQEVECEEQRLRK--------------LH----AVVETLVNH 336
++MN F +K+ ++ QR+ K +H A E LV+
Sbjct: 246 RPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGPIHILWSASEEDLVDT 305
Query: 337 RKELALNTAQFAK---------SLAMLGSSEDNTALSRALSQL--------AEVEEKIEQ 379
K++A + K S A+L + S L + AE++ K+E
Sbjct: 306 LKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMKRRDQIQAELDSKVEV 365
Query: 380 LHQEQANNDFFLLAELLSDYIRLLAIVRWESRVTQYERDFERISTVVRKEVIRFEKEKSK 439
L ++A+ D LL E + + E E + ++ + R+++
Sbjct: 366 LTYKKADTD--LLPE----------------EIGKLEDKVECANNALKADWERWKQNMQN 407
Query: 440 DFKNHVIKYLETLLYSQQQLAKYWEAFL 467
D K E ++ +Q WE+FL
Sbjct: 408 DIKLAFTDMAEENIHYYEQCLATWESFL 435
>gi|23111055 sorting nexin 7 isoform b [Homo sapiens]
Length = 336
Score = 93.6 bits (231), Expect = 4e-19
Identities = 60/236 (25%), Positives = 111/236 (47%), Gaps = 10/236 (4%)
Query: 125 SKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVK 184
+ P +++ E++ D DL + + +PE + ++ Y++ T+TS F S +F V+
Sbjct: 12 TSPLSMINQIKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEFEVR 71
Query: 185 RRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALER 244
RR+ DFL L KL E H I+PP PEK ++ G + + +F+E RR AL +
Sbjct: 72 RRYQDFLWLKGKLEEAHPT--LIIPPLPEKFIV------KGMVERFNDDFIETRRKALHK 123
Query: 245 YLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNE 304
+L RI +HPT+ + D + FL + + + G GLL + AV+ +
Sbjct: 124 FLNRIADHPTLTFNEDFKIFLTAQAW--ELSSHKKQGPGLLSRMGQTVRAVASSMRGVKN 181
Query: 305 SDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
F E +E Q++ + + + + +E ++ + +SE++
Sbjct: 182 RPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGPIHILWSASEED 237
>gi|23111047 sorting nexin 5 [Homo sapiens]
Length = 404
Score = 88.2 bits (217), Expect = 1e-17
Identities = 96/383 (25%), Positives = 177/383 (46%), Gaps = 72/383 (18%)
Query: 133 ELEEEEQEDQ-------FDLTVGITDPEKIGDGMNAY--VAYKVTTQTSLPLFRSKQFAV 183
EL ++++ED+ DL V + I D ++ V + V T+T+LP F+S +F+V
Sbjct: 6 ELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSV 65
Query: 184 KRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLI---------------GMTKVKVGK-E 227
R+ DF+ L++ L E G I+PP P K MTK + K +
Sbjct: 66 TRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMK 125
Query: 228 DSSSAEFL---EKRRAALERYLQRIVNHPTMLQDPDVREFLEKEE--LPRAVGTQTLSGA 282
AE+L +K ++ E +LQR+ +HP + +D + FLE ++ R T+ + G
Sbjct: 126 QELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFG- 184
Query: 283 GLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELA- 341
G K K+ D V +K E D +FE++ + R++ + + K +A
Sbjct: 185 GFFKSVVKSADEVLFTGVK--EVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVAD 242
Query: 342 --LNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY 399
++TA SLA+ E+ T + + L ++AE+ EK+ ++ ++++ L ELL Y
Sbjct: 243 DYIHTAACLHSLAL----EEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYY 298
Query: 400 I------------RLLAIVRWE------------------SRVTQYE--RDFERISTVVR 427
+ R A++ +E + Q E + FE++S +
Sbjct: 299 MLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAK 358
Query: 428 KEVIRFEKEKSKDFKNHVIKYLE 450
+E+I F++++ F+ ++I+ E
Sbjct: 359 EELINFKRKRVAAFRKNLIEMSE 381
>gi|7657599 sorting nexin 5 [Homo sapiens]
Length = 404
Score = 88.2 bits (217), Expect = 1e-17
Identities = 96/383 (25%), Positives = 177/383 (46%), Gaps = 72/383 (18%)
Query: 133 ELEEEEQEDQ-------FDLTVGITDPEKIGDGMNAY--VAYKVTTQTSLPLFRSKQFAV 183
EL ++++ED+ DL V + I D ++ V + V T+T+LP F+S +F+V
Sbjct: 6 ELLQQQEEDRSKLRSVSVDLNVDPSLQIDIPDALSERDKVKFTVHTKTTLPTFQSPEFSV 65
Query: 184 KRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLI---------------GMTKVKVGK-E 227
R+ DF+ L++ L E G I+PP P K MTK + K +
Sbjct: 66 TRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPREKMQKLGEGEGSMTKEEFAKMK 125
Query: 228 DSSSAEFL---EKRRAALERYLQRIVNHPTMLQDPDVREFLEKEE--LPRAVGTQTLSGA 282
AE+L +K ++ E +LQR+ +HP + +D + FLE ++ R T+ + G
Sbjct: 126 QELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHVFLEYDQDLSVRRKNTKEMFG- 184
Query: 283 GLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELA- 341
G K K+ D V +K E D +FE++ + R++ + + K +A
Sbjct: 185 GFFKSVVKSADEVLFTGVK--EVDDFFEQEKNFLINYYNRIKDSCVKADKMTRSHKNVAD 242
Query: 342 --LNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY 399
++TA SLA+ E+ T + + L ++AE+ EK+ ++ ++++ L ELL Y
Sbjct: 243 DYIHTAACLHSLAL----EEPTVIKKYLLKVAELFEKLRKVEGRVSSDEDLKLTELLRYY 298
Query: 400 I------------RLLAIVRWE------------------SRVTQYE--RDFERISTVVR 427
+ R A++ +E + Q E + FE++S +
Sbjct: 299 MLNIEAAKDLLYRRTKALIDYENSNKALDKARLKSKDVKLAEAHQQECCQKFEQLSESAK 358
Query: 428 KEVIRFEKEKSKDFKNHVIKYLE 450
+E+I F++++ F+ ++I+ E
Sbjct: 359 EELINFKRKRVAAFRKNLIEMSE 381
>gi|153791707 sorting nexin family member 30 [Homo sapiens]
Length = 437
Score = 80.9 bits (198), Expect = 2e-15
Identities = 73/363 (20%), Positives = 156/363 (42%), Gaps = 40/363 (11%)
Query: 133 ELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLG 192
+L+++ + DL V + DP+K M Y+ Y++TT+++ F +++V+RR+ DF
Sbjct: 79 QLDDDIDGETRDLFVIVDDPKKHVCTMETYITYRITTKSTRVEFDLPEYSVRRRYQDFDW 138
Query: 193 LYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNH 252
L KL E SQ ++PP PEK ++ G D S EF+E RR AL+++L+RI +H
Sbjct: 139 LRSKLEE--SQPTHLIPPLPEKFVV------KGVVDRFSEEFVETRRKALDKFLKRITDH 190
Query: 253 PTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEK 312
P + + FL ++L G LL ++ V+ K+ + F
Sbjct: 191 PVLSFNEHFNIFLTAKDL----NAYKKQGIALLTRMGESVKHVTG-GYKLRTRPLEFAAI 245
Query: 313 LQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTA--LSRALSQL 370
++ +L + + + ++ E + ++ + + E A L + +
Sbjct: 246 GDYLDTFALKLGTIDRIAQRIIKEEIEYLVELREYGPVYSTWSALEGELAEPLEGVSACI 305
Query: 371 AEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRWESRV-TQYERDFERI------- 422
+E+L + + +L E + + ++++ +V +YE E +
Sbjct: 306 GNCSTALEELTDDMTEDFLPVLREYILYSDSMKSVLKKRDQVQAEYEAKLEAVALRKEDR 365
Query: 423 -----------------STVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEA 465
+ ++ ++ R++ K +DF+ ++ + + ++ WE+
Sbjct: 366 PKVPADVEKCQDRMECFNADLKADMERWQNNKRQDFRQLLMGMADKNIQYYEKCLMAWES 425
Query: 466 FLP 468
+P
Sbjct: 426 IIP 428
>gi|72534838 sorting nexin 6B [Homo sapiens]
Length = 403
Score = 80.5 bits (197), Expect = 3e-15
Identities = 83/341 (24%), Positives = 153/341 (44%), Gaps = 54/341 (15%)
Query: 163 VAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTK- 221
V + V T++ LP F +F+V R+ +F+ L++ E G I+PP P + ++
Sbjct: 40 VKFTVQTKSCLPHFAQTEFSVVRQHEEFIWLHDAYVENEEYAGLIIPPAPPRPDFEASRE 99
Query: 222 --VKVGKEDSS-------------SAEFL---EKRRAALERYLQRIVNHPTMLQDPDVRE 263
K+G+ DSS AE+L +K A E +LQR+ HPT+ +D +
Sbjct: 100 KLQKLGEGDSSVTREEFAKMKQELEAEYLAIFKKTVAMHEVFLQRLAAHPTLRRDHNFFV 159
Query: 264 FLE--KEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQ 321
FLE ++ R + L G L + A +A+ + E D +FE + +
Sbjct: 160 FLEYGQDLSVRGKNRKELLGGFLRNIVKSADEALITGMSGLKEVDDFFEHERTFLLEYHT 219
Query: 322 RLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLH 381
R+R + ++ K LA + + +L+ LG+ E N L + +LAE+ E++ +L
Sbjct: 220 RIRDACLRADRVMRAHKCLADDYIPISAALSSLGTQEVN-QLRTSFLKLAELFERLRKLE 278
Query: 382 QEQANNDFFLLAELLSDYI------------RLLAIVRWE--------SRVTQYE----- 416
A+++ L+++L Y+ RL A+ +E +R E
Sbjct: 279 GRVASDEDLKLSDMLRYYMRDSQAAKDLLYRRLRALADYENANKALDKARTRNREVRPAE 338
Query: 417 -------RDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLE 450
+ FER+S ++E++ F+ + F+ ++I+ E
Sbjct: 339 SHQQLCCQRFERLSDSAKQELMDFKSRRVSSFRKNLIELAE 379
>gi|23111030 sorting nexin 12 [Homo sapiens]
Length = 162
Score = 75.9 bits (185), Expect = 8e-14
Identities = 48/149 (32%), Positives = 81/149 (54%), Gaps = 8/149 (5%)
Query: 124 SSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAV 183
+SKPQ +L + L + I +P+ +G G + Y+V +T+LP+F+ K+ V
Sbjct: 13 NSKPQ----DLTDAYGPPSNFLEIDIFNPQTVGVGRARFTTYEVRMRTNLPIFKLKESCV 68
Query: 184 KRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALE 243
+RR+SDF L +L E+ S+ +VPP P K+L + G E F+E+RR LE
Sbjct: 69 RRRYSDFEWLKNEL-ERDSK--IVVPPLPGKALKRQLPFR-GDEGIFEESFIEERRQGLE 124
Query: 244 RYLQRIVNHPTMLQDPDVREFLEKEELPR 272
+++ +I HP + + FL++E + R
Sbjct: 125 QFINKIAGHPLAQNERCLHMFLQEEAIDR 153
>gi|4507143 sorting nexin 3 isoform a [Homo sapiens]
Length = 162
Score = 72.4 bits (176), Expect = 8e-13
Identities = 35/129 (27%), Positives = 72/129 (55%), Gaps = 4/129 (3%)
Query: 145 LTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQN 204
L + +++P+ +G G + Y++ +T+LP+F+ K+ V+RR+SDF L SE ++
Sbjct: 29 LEIDVSNPQTVGVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWL---RSELERES 85
Query: 205 GFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREF 264
+VPP P K+ + + G + F+E+R+ LE+++ ++ HP + + F
Sbjct: 86 KVVVPPLPGKAFLRQLPFR-GDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMF 144
Query: 265 LEKEELPRA 273
L+ E + ++
Sbjct: 145 LQDEIIDKS 153
>gi|88703041 sorting nexin 6 isoform b [Homo sapiens]
Length = 418
Score = 71.2 bits (173), Expect = 2e-12
Identities = 79/361 (21%), Positives = 158/361 (43%), Gaps = 63/361 (17%)
Query: 142 QFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKH 201
Q D++ +++ +K V + V T++SLP F+ +F+V R+ +F+ L++ E
Sbjct: 45 QVDISDALSERDK--------VKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENE 96
Query: 202 SQNGFIVPPPPEKSLIGMTKVKVGK----EDSSSAEFLEKRRAALER------------- 244
G+I+PP P + ++ K+ K E S + E K + LE
Sbjct: 97 DYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMH 156
Query: 245 --YLQRIVNHPTMLQDPDVREFLE-KEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIK 301
+L R+ HP + +D + FLE ++L + K K+ D V +K
Sbjct: 157 EVFLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVK 216
Query: 302 MNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNT 361
+ D +FE + + R++ A + + K A + + SL LG ++D+T
Sbjct: 217 --DVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALG-TQDST 273
Query: 362 ALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIR-------LL-----AIVRWE 409
+ + +++E+ +K ++ + ++ L++LL Y+R LL ++V +E
Sbjct: 274 DICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYE 333
Query: 410 SR-------------VTQYE-------RDFERISTVVRKEVIRFEKEKSKDFKNHVIKYL 449
+ V Q E + FE+IS ++E+I F+ + F+ ++++
Sbjct: 334 NANKALDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELA 393
Query: 450 E 450
E
Sbjct: 394 E 394
>gi|23111026 sorting nexin 11 [Homo sapiens]
Length = 270
Score = 64.7 bits (156), Expect = 2e-10
Identities = 43/135 (31%), Positives = 70/135 (51%), Gaps = 17/135 (12%)
Query: 137 EEQEDQFDLTVGITDPEKIGDGM-NAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYE 195
E QE + +TV + DP +G N+YV YK+ T+ F +K V+RR+ +F+ L +
Sbjct: 9 ENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRK 68
Query: 196 KLSEKHSQNGFIVPPP--PEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
+L +N +VP P P KS T S EF+EKRR L+ +L++++
Sbjct: 69 QLQ----RNAGLVPVPELPGKSTFFGT----------SDEFIEKRRQGLQHFLEKVLQSV 114
Query: 254 TMLQDPDVREFLEKE 268
+L D + FL+ +
Sbjct: 115 VLLSDSQLHLFLQSQ 129
>gi|23111028 sorting nexin 11 [Homo sapiens]
Length = 270
Score = 64.7 bits (156), Expect = 2e-10
Identities = 43/135 (31%), Positives = 70/135 (51%), Gaps = 17/135 (12%)
Query: 137 EEQEDQFDLTVGITDPEKIGDGM-NAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYE 195
E QE + +TV + DP +G N+YV YK+ T+ F +K V+RR+ +F+ L +
Sbjct: 9 ENQEQEEVITVRVQDPRVQNEGSWNSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRK 68
Query: 196 KLSEKHSQNGFIVPPP--PEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
+L +N +VP P P KS T S EF+EKRR L+ +L++++
Sbjct: 69 QLQ----RNAGLVPVPELPGKSTFFGT----------SDEFIEKRRQGLQHFLEKVLQSV 114
Query: 254 TMLQDPDVREFLEKE 268
+L D + FL+ +
Sbjct: 115 VLLSDSQLHLFLQSQ 129
>gi|23397574 sorting nexin 33 [Homo sapiens]
Length = 574
Score = 57.0 bits (136), Expect = 4e-08
Identities = 104/493 (21%), Positives = 184/493 (37%), Gaps = 97/493 (19%)
Query: 26 EGAAGGSEPEAGDSDTEGE---DIFTGAAVVSKHQSPKITTSLLPINN-GSKENGIHEEQ 81
+G EP AG T G ++ A S+H + + L ++ S + G +
Sbjct: 122 DGCTVVEEPRAGGLGTNGHPPLNLSYPGAYPSQHMAFRPKPPLERQDSLASAKRGSVVGR 181
Query: 82 DQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQEATNSSKPQPTYEELEEEEQED 141
+ F + VE + K+ I + P+ + P P +E+ ++
Sbjct: 182 NLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGPRGPQWKANPHPFACSVEDPTKQT 241
Query: 142 QFDLTVGITDPEKIGDGMNAYVAYKVT-TQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEK 200
+F G+ +Y++YK+T T + P++R R+ F LY +L K
Sbjct: 242 KFK-------------GIKSYISYKLTPTHAASPVYR--------RYKHFDWLYNRLLHK 280
Query: 201 HSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPD 260
+ VP PEK G + +F+EKR+ L ++ + +HP + Q
Sbjct: 281 FTV--ISVPHLPEKQATGRFE----------EDFIEKRKRRLILWMDHMTSHPVLSQYEG 328
Query: 261 VREFL------EKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIW--FEEK 312
+ FL + + R + GA L F T+ ++ + D + F +K
Sbjct: 329 FQHFLSCLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVE-DRVDTFKAFSKK 387
Query: 313 LQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSED------------- 359
+ + + +L V LV + F K LGS+
Sbjct: 388 M------DDSVLQLSTVASELVRK------HVGGFRKEFQKLGSAFQAISHSFQMDPPFC 435
Query: 360 NTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLA----IVRW------- 408
+ AL+ A+S E I ++ EQ ND F + + LS Y LL+ I+
Sbjct: 436 SEALNSAISHTGRTYEAIGEMFAEQPKNDLFQMLDTLSLYQGLLSNFPDIIHLQKGAFAK 495
Query: 409 ---------ESRVTQYERDFER-----ISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLY 454
E R+ Q E D R + ++ E+ F + + DFK+ + YL +
Sbjct: 496 VKESQRMSDEGRMVQDEADGIRRRCRVVGFALQAEMNHFHQRRELDFKHMMQNYLRQQIL 555
Query: 455 SQQQLAKYWEAFL 467
Q++ + E L
Sbjct: 556 FYQRVGQQLEKTL 568
>gi|68800430 HCLS1 binding protein 3 [Homo sapiens]
Length = 392
Score = 53.1 bits (126), Expect = 5e-07
Identities = 50/182 (27%), Positives = 78/182 (42%), Gaps = 32/182 (17%)
Query: 144 DLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSK--------QFAVKRRFSDFLGLYE 195
DLTV E G M+ +V Y++ T L F+S QF V +++S+ Y+
Sbjct: 21 DLTVP-QHQEVRGKMMSGHVEYQILVVTRLAAFKSAKHRPEDVVQFLVSKKYSEIEEFYQ 79
Query: 196 KLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTM 255
KLS +++ +PP P K L VG+ D + +RRA L+ + +
Sbjct: 80 KLSSRYAAAS--LPPLPRKVLF------VGESD------IRERRAVFNEILRCVSKDAEL 125
Query: 256 LQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQE 315
P++ EFL GT++ AGL + D T E+ +FEE+ Q
Sbjct: 126 AGSPELLEFL---------GTRSPGAAGLTSRDSSVLDGTDSQTGNDEEAFDFFEEQDQV 176
Query: 316 VE 317
E
Sbjct: 177 AE 178
>gi|157502171 sorting nexin 19 [Homo sapiens]
Length = 992
Score = 53.1 bits (126), Expect = 5e-07
Identities = 72/268 (26%), Positives = 109/268 (40%), Gaps = 45/268 (16%)
Query: 21 LEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPKITTSLLPINNGSKENGIHEE 80
LEP+ A+ G+E E G G + TG V + + P+I I+ KE
Sbjct: 411 LEPKDGEASEGAEAEEGP----GTETETGLPVSTLNSCPEIH-----IDTADKEI----- 456
Query: 81 QDQEPQDLFADATV-----ELSLDSTQNNQKKVLAKTLISLPPQ---EATNSSKPQP--- 129
E D+ A T E + S + +K L + SL P +SS P P
Sbjct: 457 ---EQGDVTASVTALLEGPEKTCPSRPSCLEKDLTNDVSSLDPTLPPVLLSSSPPGPLSS 513
Query: 130 ---TYEELEEEEQE---DQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLP------LFR 177
++E L + +T IT E G G + Y Y V +T+L L +
Sbjct: 514 ATFSFEPLSSPDGPVIIQNLRITGTITAREHSGTGFHPYTLYTVKYETALDGENSSGLQQ 573
Query: 178 SKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEK 237
V RR+ +FL L +L EK FI K L + G DS + +E
Sbjct: 574 LAYHTVNRRYREFLNLQTRLEEKPDLRKFIKNVKGPKKL--FPDLPFGNMDS---DRVEA 628
Query: 238 RRAALERYLQRIVNHPTMLQDPDVREFL 265
R++ LE +L+++ P + +V+EFL
Sbjct: 629 RKSLLESFLKQLCAIPEIANSEEVQEFL 656
>gi|23238244 sorting nexin 16 isoform a [Homo sapiens]
Length = 344
Score = 52.0 bits (123), Expect = 1e-06
Identities = 57/254 (22%), Positives = 111/254 (43%), Gaps = 28/254 (11%)
Query: 89 FADATVELSLDSTQNNQKKVLAKTLISLPPQEATNSSKPQPTYEELEEEEQEDQFDLTVG 148
F +V +D+T + L +T + S++P+ T E+ E + T
Sbjct: 52 FKQTSVPDQMDNTSSVCSSPLIRTKFTGTASSIEYSTRPRDTEEQNPETVNWEDRPSTPT 111
Query: 149 ITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIV 208
I E + + + YK+ + + + + V RR++DF L +KL E GF +
Sbjct: 112 ILGYEVMEERAK-FTVYKILVKKT----PEESWVVFRRYTDFSRLNDKLKEMFP--GFRL 164
Query: 209 PPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKE 268
PP++ +D+ +A+FLE R+ L+ +LQ +V H + VREFL +
Sbjct: 165 ALPPKRWF----------KDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLD 214
Query: 269 ELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHA 328
+ P + L+ + + + ++ + + EK +E+E ++ L +
Sbjct: 215 DPPGPFDS--------LEESRAFCETLEETNYRLQKELL---EKQKEMESLKKLLSEKQL 263
Query: 329 VVETLVNHRKELAL 342
++TL N + L+L
Sbjct: 264 HIDTLENRIRTLSL 277
>gi|23238246 sorting nexin 16 isoform a [Homo sapiens]
Length = 344
Score = 52.0 bits (123), Expect = 1e-06
Identities = 57/254 (22%), Positives = 111/254 (43%), Gaps = 28/254 (11%)
Query: 89 FADATVELSLDSTQNNQKKVLAKTLISLPPQEATNSSKPQPTYEELEEEEQEDQFDLTVG 148
F +V +D+T + L +T + S++P+ T E+ E + T
Sbjct: 52 FKQTSVPDQMDNTSSVCSSPLIRTKFTGTASSIEYSTRPRDTEEQNPETVNWEDRPSTPT 111
Query: 149 ITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIV 208
I E + + + YK+ + + + + V RR++DF L +KL E GF +
Sbjct: 112 ILGYEVMEERAK-FTVYKILVKKT----PEESWVVFRRYTDFSRLNDKLKEMFP--GFRL 164
Query: 209 PPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKE 268
PP++ +D+ +A+FLE R+ L+ +LQ +V H + VREFL +
Sbjct: 165 ALPPKRWF----------KDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLD 214
Query: 269 ELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHA 328
+ P + L+ + + + ++ + + EK +E+E ++ L +
Sbjct: 215 DPPGPFDS--------LEESRAFCETLEETNYRLQKELL---EKQKEMESLKKLLSEKQL 263
Query: 329 VVETLVNHRKELAL 342
++TL N + L+L
Sbjct: 264 HIDTLENRIRTLSL 277
>gi|157057545 sorting nexin 18 isoform a [Homo sapiens]
Length = 624
Score = 51.2 bits (121), Expect = 2e-06
Identities = 90/383 (23%), Positives = 148/383 (38%), Gaps = 87/383 (22%)
Query: 137 EEQEDQFDLTVGITDPEKIGD--GMNAYVAYK-VTTQTSLPLFRSKQFAVKRRFSDFLGL 193
E QE+ + I DP K GM +Y++YK V T T +P V RR+ F L
Sbjct: 268 EWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVP--------VHRRYKHFDWL 319
Query: 194 YEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
Y +L+EK VP PEK G + +F+ KRR L ++ + +HP
Sbjct: 320 YARLAEKFPV--ISVPHLPEKQATGRFE----------EDFISKRRKGLIWWMNHMASHP 367
Query: 254 TMLQDPDVREFL------------------EKEELPRAVGTQTLS---GAGL-LKMFNKA 291
+ Q + FL EK+E+ A TLS A L L+
Sbjct: 368 VLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESK 427
Query: 292 TDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSL 351
D T KM++S + E ++ + +KE Q + L
Sbjct: 428 IDGFKCFTKKMDDSALQLNHTANEFARKQ------------VTGFKKEYQ-KVGQSFRGL 474
Query: 352 AM---LGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLA---- 404
+ L + L++A++ + + I +L EQ D + +LL+ Y LA
Sbjct: 475 SQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGHLANFPD 534
Query: 405 IVRWE----SRVTQYERDFER-----------------ISTVVRKEVIRFEKEKSKDFKN 443
I+ + ++V + R E IS E+ F + + +DFK+
Sbjct: 535 IIHVQKGALTKVKESRRHVEEGKMEVQKADGIQDRCNTISFATLAEIHHFHQIRVRDFKS 594
Query: 444 HVIKYL-ETLLYSQQQLAKYWEA 465
+ +L + +++ Q+ K EA
Sbjct: 595 QMQHFLQQQIIFFQKVTQKLEEA 617
>gi|23111023 sorting nexin 10 [Homo sapiens]
Length = 201
Score = 50.1 bits (118), Expect = 4e-06
Identities = 37/149 (24%), Positives = 77/149 (51%), Gaps = 21/149 (14%)
Query: 137 EEQEDQFDLTVGITDPE-KIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYE 195
E+Q+++F ++V + DP + D ++Y+ Y++ T+ F K V+RR+ +F+ L +
Sbjct: 4 EQQKEEF-VSVWVRDPRIQKEDFWHSYIDYEICIHTNSMCFTMKTSCVRRRYREFVWLRQ 62
Query: 196 KLSEKHSQNGFIV--PPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
+L N +V P P K+L + ++ + +++RR LE +L++++ +
Sbjct: 63 RL----QSNALLVQLPELPSKNLF---------FNMNNRQHVDQRRQGLEDFLRKVLQNA 109
Query: 254 TMLQDPDVREFLE----KEELPRAVGTQT 278
+L D + FL+ E++ V QT
Sbjct: 110 LLLSDSSLHLFLQSHLNSEDIEACVSGQT 138
>gi|224177511 sorting nexin 18 isoform c [Homo sapiens]
Length = 591
Score = 49.7 bits (117), Expect = 6e-06
Identities = 72/291 (24%), Positives = 113/291 (38%), Gaps = 61/291 (20%)
Query: 137 EEQEDQFDLTVGITDPEKIGD--GMNAYVAYK-VTTQTSLPLFRSKQFAVKRRFSDFLGL 193
E QE+ + I DP K GM +Y++YK V T T +P V RR+ F L
Sbjct: 268 EWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVP--------VHRRYKHFDWL 319
Query: 194 YEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
Y +L+EK VP PEK G + +F+ KRR L ++ + +HP
Sbjct: 320 YARLAEKFPV--ISVPHLPEKQATGRFE----------EDFISKRRKGLIWWMNHMASHP 367
Query: 254 TMLQDPDVREFL------------------EKEELPRAVGTQTLS---GAGL-LKMFNKA 291
+ Q + FL EK+E+ A TLS A L L+
Sbjct: 368 VLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESK 427
Query: 292 TDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSL 351
D T KM++S + E ++ + +KE Q + L
Sbjct: 428 IDGFKCFTKKMDDSALQLNHTANEFARKQ------------VTGFKKEYQ-KVGQSFRGL 474
Query: 352 AM---LGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY 399
+ L + L++A++ + + I +L EQ D + +LL+ Y
Sbjct: 475 SQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALY 525
>gi|157057543 sorting nexin 18 isoform b [Homo sapiens]
Length = 628
Score = 49.7 bits (117), Expect = 6e-06
Identities = 72/291 (24%), Positives = 113/291 (38%), Gaps = 61/291 (20%)
Query: 137 EEQEDQFDLTVGITDPEKIGD--GMNAYVAYK-VTTQTSLPLFRSKQFAVKRRFSDFLGL 193
E QE+ + I DP K GM +Y++YK V T T +P V RR+ F L
Sbjct: 268 EWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVP--------VHRRYKHFDWL 319
Query: 194 YEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHP 253
Y +L+EK VP PEK G + +F+ KRR L ++ + +HP
Sbjct: 320 YARLAEKFPV--ISVPHLPEKQATGRFE----------EDFISKRRKGLIWWMNHMASHP 367
Query: 254 TMLQDPDVREFL------------------EKEELPRAVGTQTLS---GAGL-LKMFNKA 291
+ Q + FL EK+E+ A TLS A L L+
Sbjct: 368 VLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESK 427
Query: 292 TDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSL 351
D T KM++S + E ++ + +KE Q + L
Sbjct: 428 IDGFKCFTKKMDDSALQLNHTANEFARKQ------------VTGFKKEYQ-KVGQSFRGL 474
Query: 352 AM---LGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDY 399
+ L + L++A++ + + I +L EQ D + +LL+ Y
Sbjct: 475 SQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALY 525
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 47.8 bits (112), Expect = 2e-05
Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 17/123 (13%)
Query: 146 TVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNG 205
+V I ++ + + YKV RS+ F V RR+++F LY L ++
Sbjct: 15 SVSIPSSDEHREKKKRFTVYKVLVSVG----RSEWF-VFRRYAEFDKLYNTLKKQFPAMA 69
Query: 206 FIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL 265
+P K + G D+ +F+++RRA L ++Q +V +P + PDVR FL
Sbjct: 70 LKIPA---KRIFG---------DNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFL 117
Query: 266 EKE 268
+ +
Sbjct: 118 QMD 120
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 47.8 bits (112), Expect = 2e-05
Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 17/123 (13%)
Query: 146 TVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNG 205
+V I ++ + + YKV RS+ F V RR+++F LY L ++
Sbjct: 15 SVSIPSSDEHREKKKRFTVYKVLVSVG----RSEWF-VFRRYAEFDKLYNTLKKQFPAMA 69
Query: 206 FIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL 265
+P K + G D+ +F+++RRA L ++Q +V +P + PDVR FL
Sbjct: 70 LKIPA---KRIFG---------DNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFL 117
Query: 266 EKE 268
+ +
Sbjct: 118 QMD 120
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 47.8 bits (112), Expect = 2e-05
Identities = 33/123 (26%), Positives = 58/123 (47%), Gaps = 17/123 (13%)
Query: 146 TVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNG 205
+V I ++ + + YKV RS+ F V RR+++F LY L ++
Sbjct: 15 SVSIPSSDEHREKKKRFTVYKVLVSVG----RSEWF-VFRRYAEFDKLYNTLKKQFPAMA 69
Query: 206 FIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL 265
+P K + G D+ +F+++RRA L ++Q +V +P + PDVR FL
Sbjct: 70 LKIPA---KRIFG---------DNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFL 117
Query: 266 EKE 268
+ +
Sbjct: 118 QMD 120
>gi|23943858 sorting nexin 8 [Homo sapiens]
Length = 465
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 21/114 (18%)
Query: 152 PEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPP 211
PEK G + +V Y+V++Q F+S +V RR++DF+ E L K +VP
Sbjct: 83 PEKKGLFLK-HVEYEVSSQR----FKS---SVYRRYNDFVVFQEMLLHKFPYR--MVPAL 132
Query: 212 PEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL 265
P K ++G + EF+E RR AL+R++ + HP +D ++ FL
Sbjct: 133 PPKRMLGADR-----------EFIEARRRALKRFVNLVARHPLFSEDVVLKLFL 175
>gi|7661890 sorting nexin 17 [Homo sapiens]
Length = 470
Score = 44.3 bits (103), Expect = 2e-04
Identities = 32/120 (26%), Positives = 53/120 (44%), Gaps = 21/120 (17%)
Query: 150 TDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVP 209
T+ G +AYVAY + L + R+S LGL+E+L +++ N ++P
Sbjct: 8 TESRSGDSGGSAYVAYNIHVNGVLHC--------RVRYSQLLGLHEQLRKEYGAN--VLP 57
Query: 210 PPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEE 269
P K L +T +V E+RR LE+Y+Q + P + FL + +
Sbjct: 58 AFPPKKLFSLTPAEV-----------EQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQ 106
>gi|17864088 sorting nexin 13 [Homo sapiens]
Length = 957
Score = 43.1 bits (100), Expect = 5e-04
Identities = 36/148 (24%), Positives = 60/148 (40%), Gaps = 16/148 (10%)
Query: 132 EELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFL 191
++L +D L I+D D Y Y +T L + + RR+SDF
Sbjct: 548 DDLSNVSSDDSVQLHAYISDTGVCNDHGKTYALYAITVHRR-NLNSEEMWKTYRRYSDFH 606
Query: 192 GLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVN 251
+ +++E+ I+ P +K+ M + +FLEKR+ L YLQ ++
Sbjct: 607 DFHMRITEQFESLSSILKLPGKKTFNNMDR-----------DFLEKRKKDLNAYLQLLLA 655
Query: 252 HPTMLQDPD----VREFLEKEELPRAVG 275
M P V +FLE + + G
Sbjct: 656 PEMMKASPALAHYVYDFLENKAYSKGKG 683
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.353
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,745,011
Number of Sequences: 37866
Number of extensions: 873973
Number of successful extensions: 4872
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 198
Number of HSP's that attempted gapping in prelim test: 4664
Number of HSP's gapped (non-prelim): 398
length of query: 474
length of database: 18,247,518
effective HSP length: 106
effective length of query: 368
effective length of database: 14,233,722
effective search space: 5238009696
effective search space used: 5238009696
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.