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Search of human proteins with 23111032
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|23111032 sorting nexin 1 isoform b [Homo sapiens]
(457 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|23111032 sorting nexin 1 isoform b [Homo sapiens] 900 0.0
gi|23111034 sorting nexin 1 isoform a [Homo sapiens] 836 0.0
gi|23111036 sorting nexin 1 isoform c [Homo sapiens] 711 0.0
gi|23111038 sorting nexin 2 [Homo sapiens] 537 e-153
gi|194294540 sorting nexin 7 isoform a [Homo sapiens] 100 5e-21
gi|23111047 sorting nexin 5 [Homo sapiens] 96 5e-20
gi|7657599 sorting nexin 5 [Homo sapiens] 96 5e-20
gi|72534838 sorting nexin 6B [Homo sapiens] 92 1e-18
gi|23111055 sorting nexin 7 isoform b [Homo sapiens] 86 7e-17
gi|88703041 sorting nexin 6 isoform b [Homo sapiens] 84 3e-16
gi|153791707 sorting nexin family member 30 [Homo sapiens] 80 4e-15
gi|23111030 sorting nexin 12 [Homo sapiens] 68 2e-11
gi|4507143 sorting nexin 3 isoform a [Homo sapiens] 64 2e-10
gi|68800430 HCLS1 binding protein 3 [Homo sapiens] 55 1e-07
gi|23111026 sorting nexin 11 [Homo sapiens] 55 1e-07
gi|23111028 sorting nexin 11 [Homo sapiens] 55 1e-07
gi|88703043 sorting nexin 6 isoform a [Homo sapiens] 54 2e-07
gi|23397574 sorting nexin 33 [Homo sapiens] 53 7e-07
gi|4507145 sorting nexin 4 [Homo sapiens] 51 2e-06
gi|23943858 sorting nexin 8 [Homo sapiens] 49 7e-06
gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [H... 47 5e-05
gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 47 5e-05
gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [H... 47 5e-05
gi|23238244 sorting nexin 16 isoform a [Homo sapiens] 46 6e-05
gi|23238246 sorting nexin 16 isoform a [Homo sapiens] 46 6e-05
gi|224177511 sorting nexin 18 isoform c [Homo sapiens] 45 1e-04
gi|157057545 sorting nexin 18 isoform a [Homo sapiens] 45 1e-04
gi|157057543 sorting nexin 18 isoform b [Homo sapiens] 45 1e-04
gi|23111023 sorting nexin 10 [Homo sapiens] 45 2e-04
gi|7661890 sorting nexin 17 [Homo sapiens] 44 2e-04
>gi|23111032 sorting nexin 1 isoform b [Homo sapiens]
Length = 457
Score = 900 bits (2326), Expect = 0.0
Identities = 457/457 (100%), Positives = 457/457 (100%)
Query: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
Sbjct: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
Query: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFAGDGMNAYVAYKVTTQTSLPLFRSKQFAVKR 120
ITTSLLPINNGSKENGIHEEQDQEPQDLFAGDGMNAYVAYKVTTQTSLPLFRSKQFAVKR
Sbjct: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFAGDGMNAYVAYKVTTQTSLPLFRSKQFAVKR 120
Query: 121 RFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERY 180
RFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERY
Sbjct: 121 RFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERY 180
Query: 181 LQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNES 240
LQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNES
Sbjct: 181 LQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNES 240
Query: 241 DIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSR 300
DIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSR
Sbjct: 241 DIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSR 300
Query: 301 ALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQA 360
ALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQA
Sbjct: 301 ALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQA 360
Query: 361 TLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEK 420
TLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEK
Sbjct: 361 TLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEK 420
Query: 421 SKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 457
SKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
Sbjct: 421 SKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 457
>gi|23111034 sorting nexin 1 isoform a [Homo sapiens]
Length = 522
Score = 836 bits (2159), Expect = 0.0
Identities = 444/522 (85%), Positives = 449/522 (86%), Gaps = 65/522 (12%)
Query: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
Sbjct: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
Query: 61 ITTSLLPIN--------------------------------------------------- 69
ITTSLLPIN
Sbjct: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
Query: 70 --NGSKENGIHEE-QDQEPQDLF-----------AGDGMNAYVAYKVTTQTSLPLFRSKQ 115
N SK +EE +++E +D F GDGMNAYVAYKVTTQTSLPLFRSKQ
Sbjct: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
Query: 116 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 175
FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
Sbjct: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
Query: 176 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 235
ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
Query: 236 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 295
KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
Sbjct: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
Query: 296 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW 355
TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW
Sbjct: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW 420
Query: 356 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR 415
QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR
Sbjct: 421 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR 480
Query: 416 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 457
FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
Sbjct: 481 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 522
>gi|23111036 sorting nexin 1 isoform c [Homo sapiens]
Length = 474
Score = 711 bits (1834), Expect = 0.0
Identities = 395/522 (75%), Positives = 401/522 (76%), Gaps = 113/522 (21%)
Query: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK
Sbjct: 1 MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPK 60
Query: 61 ITTSLLPIN--------------------------------------------------- 69
ITTSLLPIN
Sbjct: 61 ITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQE 120
Query: 70 --NGSKENGIHEE-QDQEPQDLF-----------AGDGMNAYVAYKVTTQTSLPLFRSKQ 115
N SK +EE +++E +D F GDGMNAYVAYKVTTQTSLPLFRSKQ
Sbjct: 121 ATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQ 180
Query: 116 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 175
FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA
Sbjct: 181 FAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRA 240
Query: 176 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 235
ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI
Sbjct: 241 ALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTI 300
Query: 236 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 295
KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN
Sbjct: 301 KMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDN 360
Query: 296 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRW 355
TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVR W+
Sbjct: 361 TALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVR---------WE-- 409
Query: 356 QDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIR 415
SRVTQYERDFERISTVVRKEVIR
Sbjct: 410 -------------------------------------SRVTQYERDFERISTVVRKEVIR 432
Query: 416 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 457
FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
Sbjct: 433 FEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 474
>gi|23111038 sorting nexin 2 [Homo sapiens]
Length = 519
Score = 537 bits (1384), Expect = e-153
Identities = 287/478 (60%), Positives = 352/478 (73%), Gaps = 37/478 (7%)
Query: 17 PFPGLEPESEGAAGGSEPEAGDS--DTEGEDIFTGAA------------VVSKHQSPKIT 62
P P P + +A + P+ + D + ED+F A ++S SP +T
Sbjct: 42 PEPASLPAEDISANSNGPKPTEVVLDDDREDLFAEATEEVSLDSPEREPILSSEPSPAVT 101
Query: 63 ----TSLLPINNGSK--------ENGIHEEQDQEPQDLF-----------AGDGMNAYVA 99
T+L+ SK + E +++ D+F GDGMNAY+A
Sbjct: 102 PVTPTTLIAPRIESKSMSAPVIFDRSREEIEEEANGDIFDIEIGVSDPEKVGDGMNAYMA 161
Query: 100 YKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKV 159
Y+VTT+TSL +F +F+VKRRFSDFLGL+ KL+ K+ G+IVPP PEKS++GMTKVKV
Sbjct: 162 YRVTTKTSLSMFSKSEFSVKRRFSDFLGLHSKLASKYLHVGYIVPPAPEKSIVGMTKVKV 221
Query: 160 GKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGL 219
GKEDSSS EF+EKRRAALERYLQR V HPT+LQDPD+R+FLE ELPRAV TQ LSGAG+
Sbjct: 222 GKEDSSSTEFVEKRRAALERYLQRTVKHPTLLQDPDLRQFLESSELPRAVNTQALSGAGI 281
Query: 220 LKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNT 279
L+M NKA DAV+KMTIKMNESD WFEEK Q+ E +Q+LRKLH VE LV HRKEL+ NT
Sbjct: 282 LRMVNKAADAVNKMTIKMNESDAWFEEKQQQFENLDQQLRKLHVSVEALVCHRKELSANT 341
Query: 280 AQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLA 339
A FAKS AMLG+SED+TALSRALSQLAEVEEKI+QLHQEQA DF++ +ELLSDYIRL+A
Sbjct: 342 AAFAKSAAMLGNSEDHTALSRALSQLAEVEEKIDQLHQEQAFADFYMFSELLSDYIRLIA 401
Query: 340 IVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYE 399
V+ FD RMK WQ+W+DAQ TL KKREAEA+++ ANKPDK+QQAK+EI EWE++V Q E
Sbjct: 402 AVKGVFDHRMKCWQKWEDAQITLLKKREAEAKMMVANKPDKIQQAKNEIREWEAKVQQGE 461
Query: 400 RDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS 457
RDFE+IS +RKEV RFEKE+ KDFK +IKYLE+L+ +QQQL KYWEAFLPEAKAI+
Sbjct: 462 RDFEQISKTIRKEVGRFEKERVKDFKTVIIKYLESLVQTQQQLIKYWEAFLPEAKAIA 519
>gi|194294540 sorting nexin 7 isoform a [Homo sapiens]
Length = 451
Score = 99.8 bits (247), Expect = 5e-21
Identities = 102/457 (22%), Positives = 196/457 (42%), Gaps = 50/457 (10%)
Query: 5 GGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPKITTS 64
GG S PFPG S G++ + E D D + +D+ V SK S S
Sbjct: 18 GGANGESPGGGAPFPG----SSGSSALLQAEVLDLDEDEDDL----EVFSKDASLMDMNS 69
Query: 65 ---LLPINNGSKENGIHEEQDQEPQDLFAG--------DGMNAYVAYKVTTQTSLPLFRS 113
++P + S N I E + + +DLF + ++ Y++ T+TS F S
Sbjct: 70 FSPMMPTSPLSMINQIKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDS 129
Query: 114 KQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKR 173
+F V+RR+ DFL L KL E H I+PP PEK ++ G + + +F+E R
Sbjct: 130 SEFEVRRRYQDFLWLKGKLEEAHPT--LIIPPLPEKFIV------KGMVERFNDDFIETR 181
Query: 174 RAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKM 233
R AL ++L RI +HPT+ + D + FL + + + G GLL + AV+
Sbjct: 182 RKALHKFLNRIADHPTLTFNEDFKIFLTAQAW--ELSSHKKQGPGLLSRMGQTVRAVASS 239
Query: 234 TIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSE 293
+ F E +E Q++ + + + + +E ++ + +SE
Sbjct: 240 MRGVKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGPIHILWSASE 299
Query: 294 DNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQ 353
++ L L +A ++ + +++ + L ++ +Y+ ++ +R + Q
Sbjct: 300 ED--LVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMKRRDQI-Q 356
Query: 354 RWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEV 413
D++ + ++A+ LL P+++ + +D++ E + ++ +
Sbjct: 357 AELDSKVEVLTYKKADTDLL----PEEIGKLEDKV--------------ECANNALKADW 398
Query: 414 IRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFL 450
R+++ D K E ++ +Q WE+FL
Sbjct: 399 ERWKQNMQNDIKLAFTDMAEENIHYYEQCLATWESFL 435
>gi|23111047 sorting nexin 5 [Homo sapiens]
Length = 404
Score = 96.3 bits (238), Expect = 5e-20
Identities = 91/360 (25%), Positives = 171/360 (47%), Gaps = 47/360 (13%)
Query: 98 VAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLI----- 152
V + V T+T+LP F+S +F+V R+ DF+ L++ L E G I+PP P K
Sbjct: 45 VKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPRE 104
Query: 153 ----------GMTKVKVGK-EDSSSAEFL---EKRRAALERYLQRIVNHPTMLQDPDVRE 198
MTK + K + AE+L +K ++ E +LQR+ +HP + +D +
Sbjct: 105 KMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHV 164
Query: 199 FLEKEE--LPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQ 256
FLE ++ R T+ + G G K K+ D V +K E D +FE++ +
Sbjct: 165 FLEYDQDLSVRRKNTKEMFG-GFFKSVVKSADEVLFTGVK--EVDDFFEQEKNFLINYYN 221
Query: 257 RLRKLHAVVETLVNHRKELA---LNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIE 313
R++ + + K +A ++TA SLA+ E+ T + + L ++AE+ EK+
Sbjct: 222 RIKDSCVKADKMTRSHKNVADDYIHTAACLHSLAL----EEPTVIKKYLLKVAELFEKLR 277
Query: 314 QLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLL 373
++ ++++ L ELL Y+ + + +R K ++++ L K R
Sbjct: 278 KVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKAR------- 330
Query: 374 WANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLE 433
+K KL +A + + + FE++S ++E+I F++++ F+ ++I+ E
Sbjct: 331 LKSKDVKLAEAHQQ---------ECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSE 381
>gi|7657599 sorting nexin 5 [Homo sapiens]
Length = 404
Score = 96.3 bits (238), Expect = 5e-20
Identities = 91/360 (25%), Positives = 171/360 (47%), Gaps = 47/360 (13%)
Query: 98 VAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLI----- 152
V + V T+T+LP F+S +F+V R+ DF+ L++ L E G I+PP P K
Sbjct: 45 VKFTVHTKTTLPTFQSPEFSVTRQHEDFVWLHDTLIETTDYAGLIIPPAPTKPDFDGPRE 104
Query: 153 ----------GMTKVKVGK-EDSSSAEFL---EKRRAALERYLQRIVNHPTMLQDPDVRE 198
MTK + K + AE+L +K ++ E +LQR+ +HP + +D +
Sbjct: 105 KMQKLGEGEGSMTKEEFAKMKQELEAEYLAVFKKTVSSHEVFLQRLSSHPVLSKDRNFHV 164
Query: 199 FLEKEE--LPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQ 256
FLE ++ R T+ + G G K K+ D V +K E D +FE++ +
Sbjct: 165 FLEYDQDLSVRRKNTKEMFG-GFFKSVVKSADEVLFTGVK--EVDDFFEQEKNFLINYYN 221
Query: 257 RLRKLHAVVETLVNHRKELA---LNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIE 313
R++ + + K +A ++TA SLA+ E+ T + + L ++AE+ EK+
Sbjct: 222 RIKDSCVKADKMTRSHKNVADDYIHTAACLHSLAL----EEPTVIKKYLLKVAELFEKLR 277
Query: 314 QLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLL 373
++ ++++ L ELL Y+ + + +R K ++++ L K R
Sbjct: 278 KVEGRVSSDEDLKLTELLRYYMLNIEAAKDLLYRRTKALIDYENSNKALDKAR------- 330
Query: 374 WANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLE 433
+K KL +A + + + FE++S ++E+I F++++ F+ ++I+ E
Sbjct: 331 LKSKDVKLAEAHQQ---------ECCQKFEQLSESAKEELINFKRKRVAAFRKNLIEMSE 381
>gi|72534838 sorting nexin 6B [Homo sapiens]
Length = 403
Score = 91.7 bits (226), Expect = 1e-18
Identities = 86/357 (24%), Positives = 162/357 (45%), Gaps = 38/357 (10%)
Query: 98 VAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTK- 156
V + V T++ LP F +F+V R+ +F+ L++ E G I+PP P + ++
Sbjct: 40 VKFTVQTKSCLPHFAQTEFSVVRQHEEFIWLHDAYVENEEYAGLIIPPAPPRPDFEASRE 99
Query: 157 --VKVGKEDSS-------------SAEFL---EKRRAALERYLQRIVNHPTMLQDPDVRE 198
K+G+ DSS AE+L +K A E +LQR+ HPT+ +D +
Sbjct: 100 KLQKLGEGDSSVTREEFAKMKQELEAEYLAIFKKTVAMHEVFLQRLAAHPTLRRDHNFFV 159
Query: 199 FLE--KEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQ 256
FLE ++ R + L G L + A +A+ + E D +FE + +
Sbjct: 160 FLEYGQDLSVRGKNRKELLGGFLRNIVKSADEALITGMSGLKEVDDFFEHERTFLLEYHT 219
Query: 257 RLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLH 316
R+R + ++ K LA + + +L+ LG+ E N L + +LAE+ E++ +L
Sbjct: 220 RIRDACLRADRVMRAHKCLADDYIPISAALSSLGTQEVN-QLRTSFLKLAELFERLRKLE 278
Query: 317 QEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWAN 376
A+++ L+++L Y+R + +R++ +++A L
Sbjct: 279 GRVASDEDLKLSDMLRYYMRDSQAAKDLLYRRLRALADYENANKAL-------------- 324
Query: 377 KPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLE 433
DK + E+ ES + FER+S ++E++ F+ + F+ ++I+ E
Sbjct: 325 --DKARTRNREVRPAESHQQLCCQRFERLSDSAKQELMDFKSRRVSSFRKNLIELAE 379
>gi|23111055 sorting nexin 7 isoform b [Homo sapiens]
Length = 336
Score = 85.9 bits (211), Expect = 7e-17
Identities = 74/337 (21%), Positives = 147/337 (43%), Gaps = 44/337 (13%)
Query: 65 LLPINNGSKENGIHEEQDQEPQDLFAG--------DGMNAYVAYKVTTQTSLPLFRSKQF 116
++P + S N I E + + +DLF + ++ Y++ T+TS F S +F
Sbjct: 9 MMPTSPLSMINQIKFEDEPDLKDLFITVDEPESHVTTIETFITYRIITKTSRGEFDSSEF 68
Query: 117 AVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAA 176
V+RR+ DFL L KL E H I+PP PEK ++ G + + +F+E RR A
Sbjct: 69 EVRRRYQDFLWLKGKLEEAHPT--LIIPPLPEKFIV------KGMVERFNDDFIETRRKA 120
Query: 177 LERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIK 236
L ++L RI +HPT+ + D + FL + + + G GLL + AV+
Sbjct: 121 LHKFLNRIADHPTLTFNEDFKIFLTAQAW--ELSSHKKQGPGLLSRMGQTVRAVASSMRG 178
Query: 237 MNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNT 296
+ F E +E Q++ + + + + +E ++ + +SE++
Sbjct: 179 VKNRPEEFMEMNNFIELFSQKINLIDKISQRIYKEEREYFDEMKEYGPIHILWSASEED- 237
Query: 297 ALSRALSQLAEVEEKIEQLHQEQAN----------NDFFLLAELLSDYIRLLAIVRAAFD 346
L L +A ++ + +++ + +++ L +E+L ++ ++A D
Sbjct: 238 -LVDTLKDVASCIDRCCKATEKRMSGLSEALLPVVHEYVLYSEMLMGVMKRRDQIQAELD 296
Query: 347 QRMK--------------TWQRWQDAQATLQKKREAE 369
+++ TW+ + +Q L + +E
Sbjct: 297 SKVEVLTYKKADTDLCLATWESFLTSQTNLHLEEASE 333
>gi|88703041 sorting nexin 6 isoform b [Homo sapiens]
Length = 418
Score = 83.6 bits (205), Expect = 3e-16
Identities = 78/356 (21%), Positives = 155/356 (43%), Gaps = 39/356 (10%)
Query: 98 VAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKV 157
V + V T++SLP F+ +F+V R+ +F+ L++ E G+I+PP P + ++
Sbjct: 58 VKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASRE 117
Query: 158 KVGK----EDSSSAEFLEKRRAALER---------------YLQRIVNHPTMLQDPDVRE 198
K+ K E S + E K + LE +L R+ HP + +D +
Sbjct: 118 KLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHV 177
Query: 199 FLE-KEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQR 257
FLE ++L + K K+ D V +K + D +FE + + R
Sbjct: 178 FLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVK--DVDDFFEHERTFLLEYHNR 235
Query: 258 LRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQ 317
++ A + + K A + + SL LG ++D+T + + +++E+ +K ++
Sbjct: 236 VKDASAKSDRMTRSHKSAADDYNRIGSSLYALG-TQDSTDICKFFLKVSELFDKTRKIEA 294
Query: 318 EQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANK 377
+ ++ L++LL Y+R + +R ++ +++A L K R +L A
Sbjct: 295 RVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAET 354
Query: 378 PDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLE 433
+L K FE+IS ++E+I F+ + F+ ++++ E
Sbjct: 355 SQQLCCQK----------------FEKISESAKQELIDFKTRRVAAFRKNLVELAE 394
>gi|153791707 sorting nexin family member 30 [Homo sapiens]
Length = 437
Score = 80.1 bits (196), Expect = 4e-15
Identities = 96/450 (21%), Positives = 185/450 (41%), Gaps = 57/450 (12%)
Query: 17 PFPGLEPESEGAAGGSEPEAGD-----SDTEGEDIFTGAAVVSKHQSPKITTSLLPINNG 71
P P SE A GG + D S + + I + SP ++SLL
Sbjct: 21 PHPLAGSSSEEAVGGDSTPSPDLLMARSFGDKDLILPNGGTPAGTSSPASSSSLL----- 75
Query: 72 SKENGIHEEQDQEPQDLFAGDG--------MNAYVAYKVTTQTSLPLFRSKQFAVKRRFS 123
+ ++ D E +DLF M Y+ Y++TT+++ F +++V+RR+
Sbjct: 76 -NRLQLDDDIDGETRDLFVIVDDPKKHVCTMETYITYRITTKSTRVEFDLPEYSVRRRYQ 134
Query: 124 DFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQR 183
DF L KL E SQ ++PP PEK ++ G D S EF+E RR AL+++L+R
Sbjct: 135 DFDWLRSKLEE--SQPTHLIPPLPEKFVVK------GVVDRFSEEFVETRRKALDKFLKR 186
Query: 184 IVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIW 243
I +HP + + FL ++L G LL ++ V+ K+ +
Sbjct: 187 ITDHPVLSFNEHFNIFLTAKDL----NAYKKQGIALLTRMGESVKHVTG-GYKLRTRPLE 241
Query: 244 FEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTA--LSRA 301
F ++ +L + + + ++ E + ++ + + E A L
Sbjct: 242 FAAIGDYLDTFALKLGTIDRIAQRIIKEEIEYLVELREYGPVYSTWSALEGELAEPLEGV 301
Query: 302 LSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQAT 361
+ + +E+L + DF +L +YI + MK+ + +D
Sbjct: 302 SACIGNCSTALEEL-TDDMTEDFL---PVLREYI--------LYSDSMKSVLKKRD---Q 346
Query: 362 LQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKS 421
+Q + EA+ + K D+ + D V + + E + ++ ++ R++ K
Sbjct: 347 VQAEYEAKLEAVALRKEDRPKVPAD--------VEKCQDRMECFNADLKADMERWQNNKR 398
Query: 422 KDFKNHVIKYLETLLYSQQQLAKYWEAFLP 451
+DF+ ++ + + ++ WE+ +P
Sbjct: 399 QDFRQLLMGMADKNIQYYEKCLMAWESIIP 428
>gi|23111030 sorting nexin 12 [Homo sapiens]
Length = 162
Score = 68.2 bits (165), Expect = 2e-11
Identities = 40/117 (34%), Positives = 66/117 (56%), Gaps = 4/117 (3%)
Query: 91 GDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKS 150
G G + Y+V +T+LP+F+ K+ V+RR+SDF L +L E+ S+ +VPP P K+
Sbjct: 41 GVGRARFTTYEVRMRTNLPIFKLKESCVRRRYSDFEWLKNEL-ERDSK--IVVPPLPGKA 97
Query: 151 LIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPR 207
L + G E F+E+RR LE+++ +I HP + + FL++E + R
Sbjct: 98 LKRQLPFR-GDEGIFEESFIEERRQGLEQFINKIAGHPLAQNERCLHMFLQEEAIDR 153
>gi|4507143 sorting nexin 3 isoform a [Homo sapiens]
Length = 162
Score = 64.3 bits (155), Expect = 2e-10
Identities = 33/118 (27%), Positives = 64/118 (54%), Gaps = 4/118 (3%)
Query: 91 GDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKS 150
G G + Y++ +T+LP+F+ K+ V+RR+SDF L SE ++ +VPP P K+
Sbjct: 40 GVGRGRFTTYEIRVKTNLPIFKLKESTVRRRYSDFEWL---RSELERESKVVVPPLPGKA 96
Query: 151 LIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRA 208
+ + G + F+E+R+ LE+++ ++ HP + + FL+ E + ++
Sbjct: 97 FLRQLPFR-GDDGIFDDNFIEERKQGLEQFINKVAGHPLAQNERCLHMFLQDEIIDKS 153
>gi|68800430 HCLS1 binding protein 3 [Homo sapiens]
Length = 392
Score = 55.1 bits (131), Expect = 1e-07
Identities = 52/204 (25%), Positives = 85/204 (41%), Gaps = 35/204 (17%)
Query: 57 QSPKITTSLLPINNGSKENGIHEEQDQEPQDLFAGDGMNAYVAYKVTTQTSLPLFRSK-- 114
QSP + + + N + Q QE + G M+ +V Y++ T L F+S
Sbjct: 2 QSPAVLVTSRRLQNAHTGLDLTVPQHQEVR----GKMMSGHVEYQILVVTRLAAFKSAKH 57
Query: 115 ------QFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAE 168
QF V +++S+ Y+KLS +++ +PP P K L VG+ D
Sbjct: 58 RPEDVVQFLVSKKYSEIEEFYQKLSSRYAAAS--LPPLPRKVLF------VGESD----- 104
Query: 169 FLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATD 228
+ +RRA L+ + + P++ EFL GT++ AGL + D
Sbjct: 105 -IRERRAVFNEILRCVSKDAELAGSPELLEFL---------GTRSPGAAGLTSRDSSVLD 154
Query: 229 AVSKMTIKMNESDIWFEEKLQEVE 252
T E+ +FEE+ Q E
Sbjct: 155 GTDSQTGNDEEAFDFFEEQDQVAE 178
>gi|23111026 sorting nexin 11 [Homo sapiens]
Length = 270
Score = 55.1 bits (131), Expect = 1e-07
Identities = 35/111 (31%), Positives = 58/111 (52%), Gaps = 16/111 (14%)
Query: 95 NAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPP--PEKSLI 152
N+YV YK+ T+ F +K V+RR+ +F+ L ++L +N +VP P P KS
Sbjct: 33 NSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQ----RNAGLVPVPELPGKSTF 88
Query: 153 GMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKE 203
T S EF+EKRR L+ +L++++ +L D + FL+ +
Sbjct: 89 FGT----------SDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQ 129
>gi|23111028 sorting nexin 11 [Homo sapiens]
Length = 270
Score = 55.1 bits (131), Expect = 1e-07
Identities = 35/111 (31%), Positives = 58/111 (52%), Gaps = 16/111 (14%)
Query: 95 NAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPP--PEKSLI 152
N+YV YK+ T+ F +K V+RR+ +F+ L ++L +N +VP P P KS
Sbjct: 33 NSYVDYKIFLHTNSKAFTAKTSCVRRRYREFVWLRKQLQ----RNAGLVPVPELPGKSTF 88
Query: 153 GMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKE 203
T S EF+EKRR L+ +L++++ +L D + FL+ +
Sbjct: 89 FGT----------SDEFIEKRRQGLQHFLEKVLQSVVLLSDSQLHLFLQSQ 129
>gi|88703043 sorting nexin 6 isoform a [Homo sapiens]
Length = 290
Score = 54.3 bits (129), Expect = 2e-07
Identities = 62/285 (21%), Positives = 124/285 (43%), Gaps = 24/285 (8%)
Query: 154 MTKVKVGK-EDSSSAEFL---EKRRAALERYLQRIVNHPTMLQDPDVREFLE-KEELPRA 208
MTK + K + AE+L +K A E +L R+ HP + +D + FLE ++L
Sbjct: 1 MTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLEYNQDLSVR 60
Query: 209 VGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETL 268
+ K K+ D V +K + D +FE + + R++ A + +
Sbjct: 61 GKNKKEKLEDFFKNMVKSADGVIVSGVK--DVDDFFEHERTFLLEYHNRVKDASAKSDRM 118
Query: 269 VNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLA 328
K A + + SL LG ++D+T + + +++E+ +K ++ + ++ L+
Sbjct: 119 TRSHKSAADDYNRIGSSLYALG-TQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLS 177
Query: 329 ELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEI 388
+LL Y+R + +R ++ +++A L K R +L A +L K
Sbjct: 178 DLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQK--- 234
Query: 389 LEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLE 433
FE+IS ++E+I F+ + F+ ++++ E
Sbjct: 235 -------------FEKISESAKQELIDFKTRRVAAFRKNLVELAE 266
>gi|23397574 sorting nexin 33 [Homo sapiens]
Length = 574
Score = 52.8 bits (125), Expect = 7e-07
Identities = 83/380 (21%), Positives = 145/380 (38%), Gaps = 78/380 (20%)
Query: 93 GMNAYVAYKVT-TQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSL 151
G+ +Y++YK+T T + P++R R+ F LY +L K + VP PEK
Sbjct: 245 GIKSYISYKLTPTHAASPVYR--------RYKHFDWLYNRLLHKFTV--ISVPHLPEKQA 294
Query: 152 IGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL------EKEEL 205
G + +F+EKR+ L ++ + +HP + Q + FL + +
Sbjct: 295 TGRFE----------EDFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWKMG 344
Query: 206 PRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIW--FEEKLQEVECEEQRLRKLHA 263
R + GA L F T+ ++ + D + F +K+ + + +L
Sbjct: 345 KRRAEKDEMVGASFLLTFQIPTEHQDLQDVE-DRVDTFKAFSKKM------DDSVLQLST 397
Query: 264 VVETLVNHRKELALNTAQFAKSLAMLGSSED-------------NTALSRALSQLAEVEE 310
V LV + F K LGS+ + AL+ A+S E
Sbjct: 398 VASELVRK------HVGGFRKEFQKLGSAFQAISHSFQMDPPFCSEALNSAISHTGRTYE 451
Query: 311 KIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEA 370
I ++ EQ ND F + + LS Y LL+ + D LQK A+
Sbjct: 452 AIGEMFAEQPKNDLFQMLDTLSLYQGLLS--------------NFPDI-IHLQKGAFAKV 496
Query: 371 RLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIK 430
+ + Q+ DE + R + ++ E+ F + + DFK+ +
Sbjct: 497 K--------ESQRMSDEGRMVQDEADGIRRRCRVVGFALQAEMNHFHQRRELDFKHMMQN 548
Query: 431 YLETLLYSQQQLAKYWEAFL 450
YL + Q++ + E L
Sbjct: 549 YLRQQILFYQRVGQQLEKTL 568
>gi|4507145 sorting nexin 4 [Homo sapiens]
Length = 450
Score = 51.2 bits (121), Expect = 2e-06
Identities = 108/456 (23%), Positives = 170/456 (37%), Gaps = 84/456 (18%)
Query: 12 ERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPKITTSLLPINNG 71
E L P GL GAA G E E ++ G D T H + + + ++
Sbjct: 18 EPLGSPDAGL-----GAAVGKEAEGAGEESSGVDTMT-------HNNFWLKKIEISVSEA 65
Query: 72 SKENGIHEEQDQEPQDLFAGDGMNAYVAYKVTTQTSLPLFRSKQF--AVKRRFSDFLGLY 129
K G + QE Y AY + T++ ++ RR+S+F L
Sbjct: 66 EKRTGRNAMNMQE-----------TYTAYLIETRSVEHTDGQSVLTDSLWRRYSEFELLR 114
Query: 130 EKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPT 189
L + +VPP PEK + D+ +F+E+RR LE +L RI +HP
Sbjct: 115 SYLLVYYPH--IVVPPLPEKRAEFVWHKL--SADNMDPDFVERRRIGLENFLLRIASHPI 170
Query: 190 MLQDPDVREFLEKE----ELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFE 245
+ +D FL +E E G Q L LK N AT V + + +
Sbjct: 171 LCRDKIFYLFLTQEGNWKETVNETGFQ-LKADSRLKALN-ATFRVKNPDKRFTDLK-HYS 227
Query: 246 EKLQEVECEEQRLR-----KLHAVVETLVNHRK---ELALNTAQFAKSLAMLGSSEDNTA 297
++LQ V R+R +L+ V + N+ + E + + L G D A
Sbjct: 228 DELQSVISHLLRVRARVADRLYGVYKVHGNYGRVFSEWSAIEKEMGDGLQSAGHHMDVYA 287
Query: 298 LSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVR-----AAFDQRMKTW 352
S + + E EE H ++ AE L R +++ AA D K
Sbjct: 288 SS--IDDILEDEE-----HYADQLKEYLFYAEALRAVCRKHELMQYDLEMAAQDLASKKQ 340
Query: 353 QRWQDAQATLQ-----------------KKREAEARLLWANKPDKLQQAKDEILEWESRV 395
Q + T++ ++REA ++L + QQ K + LE V
Sbjct: 341 QCEELVTGTVRTFSLKGMTTKLFGQETPEQREARIKVLEEQINEGEQQLKSKNLEGREFV 400
Query: 396 TQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKY 431
D E RF+++K++D K +I Y
Sbjct: 401 KNAWADIE-----------RFKEQKNRDLKEALISY 425
>gi|23943858 sorting nexin 8 [Homo sapiens]
Length = 465
Score = 49.3 bits (116), Expect = 7e-06
Identities = 95/425 (22%), Positives = 170/425 (40%), Gaps = 77/425 (18%)
Query: 10 ASERLPPPFPGLEPESEGAAGGSEPEAGDSDT----EGEDIFTGAAVVSKHQSPKITTSL 65
A + LP G E+E A ++P A D T E + I S+ Q P+ L
Sbjct: 5 AMDPLPAAAVGAAAEAE-ADEEADPPASDLPTPQAIEPQAIVQQVPAPSRMQMPQGNPLL 63
Query: 66 LP--INNGSKENGIHEEQDQEPQDLFAGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFS 123
L + + + E E + LF +V Y+V++Q F+S +V RR++
Sbjct: 64 LSHTLQELLARDTVQVELIPEKKGLFL-----KHVEYEVSSQR----FKS---SVYRRYN 111
Query: 124 DFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQR 183
DF+ E L K +VP P K ++G + EF+E RR AL+R++
Sbjct: 112 DFVVFQEMLLHKFPYR--MVPALPPKRMLGADR-----------EFIEARRRALKRFVNL 158
Query: 184 IVNHPTMLQDPDVREFL---------EKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMT 234
+ HP +D ++ FL + +E + VG + L+ K+ +A D +
Sbjct: 159 VARHPLFSEDVVLKLFLSFSGSDVQNKLKESAQCVGDEFLN----CKLATRAKDFLPA-- 212
Query: 235 IKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGS--- 291
+ F + + KL E + + + A + F K L+ +GS
Sbjct: 213 ----DIQAQFAISRELIRNIYNSFHKLRDRAERIASRAIDNAADLLIFGKELSAIGSDTT 268
Query: 292 ---------SEDNTALSRALS----QLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLL 338
S +L +AL + A + +K Q +++ N+ + E L+ ++ LL
Sbjct: 269 PLPSWAALNSSTWGSLKQALKGLSVEFALLADKAAQQGKQEEND----VVEKLNLFLDLL 324
Query: 339 AIVRAAFDQRMKTWQRWQDAQATLQK----KREAEARLLWANKPDKLQQAKDEILEWESR 394
+ ++ K Q L K KR+ + +P+ ++Q + I+E E+
Sbjct: 325 QSYKDLCERHEK--GVLHKHQRALHKYSLMKRQMMSATAQNREPESVEQLESRIVEQENA 382
Query: 395 VTQYE 399
+ E
Sbjct: 383 IQTME 387
>gi|31563383 serum/glucocorticoid regulated kinase 3 isoform 2 [Homo
sapiens]
Length = 464
Score = 46.6 bits (109), Expect = 5e-05
Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 17/107 (15%)
Query: 97 YVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTK 156
+ YKV RS+ F V RR+++F LY L ++ +P K + G
Sbjct: 31 FTVYKVLVSVG----RSEWF-VFRRYAEFDKLYNTLKKQFPAMALKIPA---KRIFG--- 79
Query: 157 VKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKE 203
D+ +F+++RRA L ++Q +V +P + PDVR FL+ +
Sbjct: 80 ------DNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
>gi|31563382 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 46.6 bits (109), Expect = 5e-05
Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 17/107 (15%)
Query: 97 YVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTK 156
+ YKV RS+ F V RR+++F LY L ++ +P K + G
Sbjct: 31 FTVYKVLVSVG----RSEWF-VFRRYAEFDKLYNTLKKQFPAMALKIPA---KRIFG--- 79
Query: 157 VKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKE 203
D+ +F+++RRA L ++Q +V +P + PDVR FL+ +
Sbjct: 80 ------DNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
>gi|75813626 serum/glucocorticoid regulated kinase 3 isoform 1 [Homo
sapiens]
Length = 496
Score = 46.6 bits (109), Expect = 5e-05
Identities = 31/107 (28%), Positives = 52/107 (48%), Gaps = 17/107 (15%)
Query: 97 YVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTK 156
+ YKV RS+ F V RR+++F LY L ++ +P K + G
Sbjct: 31 FTVYKVLVSVG----RSEWF-VFRRYAEFDKLYNTLKKQFPAMALKIPA---KRIFG--- 79
Query: 157 VKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKE 203
D+ +F+++RRA L ++Q +V +P + PDVR FL+ +
Sbjct: 80 ------DNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMD 120
>gi|23238244 sorting nexin 16 isoform a [Homo sapiens]
Length = 344
Score = 46.2 bits (108), Expect = 6e-05
Identities = 43/181 (23%), Positives = 84/181 (46%), Gaps = 27/181 (14%)
Query: 97 YVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTK 156
+ YK+ + + + + V RR++DF L +KL E GF + PP++
Sbjct: 124 FTVYKILVKKT----PEESWVVFRRYTDFSRLNDKLKEMFP--GFRLALPPKRWF----- 172
Query: 157 VKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSG 216
+D+ +A+FLE R+ L+ +LQ +V H + VREFL ++ P +
Sbjct: 173 -----KDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLDDPPGPFDS----- 222
Query: 217 AGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELA 276
L+ + + + ++ + + EK +E+E ++ L + ++TL N + L+
Sbjct: 223 ---LEESRAFCETLEETNYRLQKELL---EKQKEMESLKKLLSEKQLHIDTLENRIRTLS 276
Query: 277 L 277
L
Sbjct: 277 L 277
>gi|23238246 sorting nexin 16 isoform a [Homo sapiens]
Length = 344
Score = 46.2 bits (108), Expect = 6e-05
Identities = 43/181 (23%), Positives = 84/181 (46%), Gaps = 27/181 (14%)
Query: 97 YVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTK 156
+ YK+ + + + + V RR++DF L +KL E GF + PP++
Sbjct: 124 FTVYKILVKKT----PEESWVVFRRYTDFSRLNDKLKEMFP--GFRLALPPKRWF----- 172
Query: 157 VKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSG 216
+D+ +A+FLE R+ L+ +LQ +V H + VREFL ++ P +
Sbjct: 173 -----KDNYNADFLEDRQLGLQAFLQNLVAHKDIANCLAVREFLCLDDPPGPFDS----- 222
Query: 217 AGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELA 276
L+ + + + ++ + + EK +E+E ++ L + ++TL N + L+
Sbjct: 223 ---LEESRAFCETLEETNYRLQKELL---EKQKEMESLKKLLSEKQLHIDTLENRIRTLS 276
Query: 277 L 277
L
Sbjct: 277 L 277
>gi|224177511 sorting nexin 18 isoform c [Homo sapiens]
Length = 591
Score = 45.4 bits (106), Expect = 1e-04
Identities = 65/268 (24%), Positives = 104/268 (38%), Gaps = 59/268 (22%)
Query: 93 GMNAYVAYK-VTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSL 151
GM +Y++YK V T T +P V RR+ F LY +L+EK VP PEK
Sbjct: 291 GMKSYISYKLVPTHTQVP--------VHRRYKHFDWLYARLAEKFPV--ISVPHLPEKQA 340
Query: 152 IGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL----------- 200
G + +F+ KRR L ++ + +HP + Q + FL
Sbjct: 341 TGRFE----------EDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAW 390
Query: 201 -------EKEELPRAVGTQTLS---GAGL-LKMFNKATDAVSKMTIKMNESDIWFEEKLQ 249
EK+E+ A TLS A L L+ D T KM++S +
Sbjct: 391 KQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTAN 450
Query: 250 EVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAM---LGSSEDNTALSRALSQLA 306
E ++ + +KE Q + L+ L + L++A++
Sbjct: 451 EFARKQ------------VTGFKKEYQ-KVGQSFRGLSQAFELDQQAFSVGLNQAIAFTG 497
Query: 307 EVEEKIEQLHQEQANNDFFLLAELLSDY 334
+ + I +L EQ D + +LL+ Y
Sbjct: 498 DAYDAIGELFAEQPRQDLDPVMDLLALY 525
>gi|157057545 sorting nexin 18 isoform a [Homo sapiens]
Length = 624
Score = 45.4 bits (106), Expect = 1e-04
Identities = 65/268 (24%), Positives = 104/268 (38%), Gaps = 59/268 (22%)
Query: 93 GMNAYVAYK-VTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSL 151
GM +Y++YK V T T +P V RR+ F LY +L+EK VP PEK
Sbjct: 291 GMKSYISYKLVPTHTQVP--------VHRRYKHFDWLYARLAEKFPV--ISVPHLPEKQA 340
Query: 152 IGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL----------- 200
G + +F+ KRR L ++ + +HP + Q + FL
Sbjct: 341 TGRFE----------EDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAW 390
Query: 201 -------EKEELPRAVGTQTLS---GAGL-LKMFNKATDAVSKMTIKMNESDIWFEEKLQ 249
EK+E+ A TLS A L L+ D T KM++S +
Sbjct: 391 KQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTAN 450
Query: 250 EVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAM---LGSSEDNTALSRALSQLA 306
E ++ + +KE Q + L+ L + L++A++
Sbjct: 451 EFARKQ------------VTGFKKEYQ-KVGQSFRGLSQAFELDQQAFSVGLNQAIAFTG 497
Query: 307 EVEEKIEQLHQEQANNDFFLLAELLSDY 334
+ + I +L EQ D + +LL+ Y
Sbjct: 498 DAYDAIGELFAEQPRQDLDPVMDLLALY 525
>gi|157057543 sorting nexin 18 isoform b [Homo sapiens]
Length = 628
Score = 45.4 bits (106), Expect = 1e-04
Identities = 65/268 (24%), Positives = 104/268 (38%), Gaps = 59/268 (22%)
Query: 93 GMNAYVAYK-VTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSL 151
GM +Y++YK V T T +P V RR+ F LY +L+EK VP PEK
Sbjct: 291 GMKSYISYKLVPTHTQVP--------VHRRYKHFDWLYARLAEKFPV--ISVPHLPEKQA 340
Query: 152 IGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFL----------- 200
G + +F+ KRR L ++ + +HP + Q + FL
Sbjct: 341 TGRFE----------EDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAW 390
Query: 201 -------EKEELPRAVGTQTLS---GAGL-LKMFNKATDAVSKMTIKMNESDIWFEEKLQ 249
EK+E+ A TLS A L L+ D T KM++S +
Sbjct: 391 KQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTAN 450
Query: 250 EVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAM---LGSSEDNTALSRALSQLA 306
E ++ + +KE Q + L+ L + L++A++
Sbjct: 451 EFARKQ------------VTGFKKEYQ-KVGQSFRGLSQAFELDQQAFSVGLNQAIAFTG 497
Query: 307 EVEEKIEQLHQEQANNDFFLLAELLSDY 334
+ + I +L EQ D + +LL+ Y
Sbjct: 498 DAYDAIGELFAEQPRQDLDPVMDLLALY 525
>gi|23111023 sorting nexin 10 [Homo sapiens]
Length = 201
Score = 44.7 bits (104), Expect = 2e-04
Identities = 31/128 (24%), Positives = 63/128 (49%), Gaps = 19/128 (14%)
Query: 92 DGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIV--PPPPEK 149
D ++Y+ Y++ T+ F K V+RR+ +F+ L ++L N +V P P K
Sbjct: 24 DFWHSYIDYEICIHTNSMCFTMKTSCVRRRYREFVWLRQRL----QSNALLVQLPELPSK 79
Query: 150 SLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLE----KEEL 205
+L + ++ + +++RR LE +L++++ + +L D + FL+ E++
Sbjct: 80 NLF---------FNMNNRQHVDQRRQGLEDFLRKVLQNALLLSDSSLHLFLQSHLNSEDI 130
Query: 206 PRAVGTQT 213
V QT
Sbjct: 131 EACVSGQT 138
>gi|7661890 sorting nexin 17 [Homo sapiens]
Length = 470
Score = 44.3 bits (103), Expect = 2e-04
Identities = 33/116 (28%), Positives = 54/116 (46%), Gaps = 22/116 (18%)
Query: 90 AGD-GMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPE 148
+GD G +AYVAY + L + R+S LGL+E+L +++ N ++P P
Sbjct: 12 SGDSGGSAYVAYNIHVNGVLHC--------RVRYSQLLGLHEQLRKEYGAN--VLPAFPP 61
Query: 149 KSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEE 204
K L +T +V E+RR LE+Y+Q + P + FL + +
Sbjct: 62 KKLFSLTPAEV-----------EQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQ 106
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,721,023
Number of Sequences: 37866
Number of extensions: 801553
Number of successful extensions: 3908
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 35
Number of HSP's successfully gapped in prelim test: 233
Number of HSP's that attempted gapping in prelim test: 3681
Number of HSP's gapped (non-prelim): 468
length of query: 457
length of database: 18,247,518
effective HSP length: 106
effective length of query: 351
effective length of database: 14,233,722
effective search space: 4996036422
effective search space used: 4996036422
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.