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Search of human proteins with 22907049
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
(453 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 907 0.0
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 907 0.0
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 907 0.0
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 639 0.0
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 639 0.0
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 502 e-142
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 502 e-142
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 471 e-133
gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens] 407 e-113
gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens] 407 e-113
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 161 1e-39
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 159 4e-39
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 152 5e-37
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 152 6e-37
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 147 2e-35
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 145 7e-35
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 144 1e-34
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 143 3e-34
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 136 3e-32
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 136 4e-32
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 134 2e-31
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 126 4e-29
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 125 1e-28
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 125 1e-28
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 103 4e-22
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 92 1e-18
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 79 1e-14
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 79 1e-14
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 79 1e-14
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 46 6e-05
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 907 bits (2345), Expect = 0.0
Identities = 453/453 (100%), Positives = 453/453 (100%)
Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 907 bits (2345), Expect = 0.0
Identities = 453/453 (100%), Positives = 453/453 (100%)
Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 907 bits (2345), Expect = 0.0
Identities = 453/453 (100%), Positives = 453/453 (100%)
Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY
Sbjct: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL
Sbjct: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER
Sbjct: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS
Sbjct: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG
Sbjct: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK
Sbjct: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE
Sbjct: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453
TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH
Sbjct: 421 TFSHRRSCLVRPLMNDEGLKVRYPPSPAKMTQH 453
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 639 bits (1648), Expect = 0.0
Identities = 297/439 (67%), Positives = 377/439 (85%)
Query: 8 VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67
V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V
Sbjct: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
Query: 68 LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127
L EI++M++ LPEW +PV+K T DE YI +PLGVVL+IG WNYPF LTIQP++G
Sbjct: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
Query: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187
AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT
Sbjct: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
Query: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247
G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP
Sbjct: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
Query: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307
DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG
Sbjct: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
Query: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367
D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F
Sbjct: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
Query: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427
S N K+IK+MI ETSSGGV NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R
Sbjct: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
Query: 428 CLVRPLMNDEGLKVRYPPS 446
CL++ L + K+RYPP+
Sbjct: 425 CLLKSLKREGANKLRYPPN 443
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 639 bits (1648), Expect = 0.0
Identities = 297/439 (67%), Positives = 377/439 (85%)
Query: 8 VKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYV 67
V+R R AF SGR+RPL+FR+QQLEAL+R++QE+E++++ A+AADL K+E+N Y +EV+ V
Sbjct: 5 VRRVRQAFLSGRSRPLRFRLQQLEALRRMVQEREKDILTAIAADLCKSEFNVYSQEVITV 64
Query: 68 LEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVG 127
L EI++M++ LPEW +PV+K T DE YI +PLGVVL+IG WNYPF LTIQP++G
Sbjct: 65 LGEIDFMLENLPEWVTAKPVKKNVLTMLDEAYIQPQPLGVVLIIGAWNYPFVLTIQPLIG 124
Query: 128 AIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYT 187
AIAAGN+V++KPSELSEN A +LA ++PQYLD+DLY VINGGV ETTELLK+RFDHI YT
Sbjct: 125 AIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDLYIVINGGVEETTELLKQRFDHIFYT 184
Query: 188 GSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAP 247
G+T VGKI+M AAAKHLTPVTLELGGKSPCY+DK+CDLD+ CRRI WGK+MN GQTC+AP
Sbjct: 185 GNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDKDCDLDIVCRRITWGKYMNCGQTCIAP 244
Query: 248 DYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGG 307
DYILC+ S+QNQIV K+K+++KEFYGE+ K+S DY RII+ RHF+R++ L+EGQK+A+GG
Sbjct: 245 DYILCEASLQNQIVWKIKETVKEFYGENIKESPDYERIINLRHFKRILSLLEGQKIAFGG 304
Query: 308 TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMF 367
D ATRYIAPT+LTDVDP++ VMQEEIFGP+LPIV V++++EAI FIN+REKPLALY+F
Sbjct: 305 ETDEATRYIAPTVLTDVDPKTKVMQEEIFGPILPIVPVKNVDEAINFINEREKPLALYVF 364
Query: 368 SSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRS 427
S N K+IK+MI ETSSGGV NDVI+H TL+S PFGGVG+SGMG+YHGK SF+TFSH+R
Sbjct: 365 SHNHKLIKRMIDETSSGGVTGNDVIMHFTLNSFPFGGVGSSGMGAYHGKHSFDTFSHQRP 424
Query: 428 CLVRPLMNDEGLKVRYPPS 446
CL++ L + K+RYPP+
Sbjct: 425 CLLKSLKREGANKLRYPPN 443
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 502 bits (1292), Expect = e-142
Identities = 242/451 (53%), Positives = 324/451 (71%), Gaps = 1/451 (0%)
Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
M + + ++R R AF +GRTRP +FR QL+ L R +QE +Q L ALA DLHK+ + +
Sbjct: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
EV E+ ++ L W DE V K TQ D +I EP G+VL+I WNYP NL
Sbjct: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
T+ P+VGA+AAGN VVLKPSE+S+N+ +LA ++PQY+D+ + V+ GG ET +LL+ R
Sbjct: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
FD+I +TGS VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD R+AW ++ N+
Sbjct: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
GQTCVAPDY+LC P +Q +++ L+ ++ FYG+D + S + GRII+ + FQR+ L+
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
+VA GG D + RYIAPT+L DV PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
PLALY FS++ +V+K+++ +TSSGG ND +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
TFSH R+CL+R ++ +RYPP SP ++
Sbjct: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 451
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 502 bits (1292), Expect = e-142
Identities = 242/451 (53%), Positives = 324/451 (71%), Gaps = 1/451 (0%)
Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
M + + ++R R AF +GRTRP +FR QL+ L R +QE +Q L ALA DLHK+ + +
Sbjct: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESE 60
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
EV E+ ++ L W DE V K TQ D +I EP G+VL+I WNYP NL
Sbjct: 61 VSEVAISQGEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNL 120
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
T+ P+VGA+AAGN VVLKPSE+S+N+ +LA ++PQY+D+ + V+ GG ET +LL+ R
Sbjct: 121 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 180
Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
FD+I +TGS VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD R+AW ++ N+
Sbjct: 181 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 240
Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
GQTCVAPDY+LC P +Q +++ L+ ++ FYG+D + S + GRII+ + FQR+ L+
Sbjct: 241 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 300
Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
+VA GG D + RYIAPT+L DV PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 301 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 360
Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
PLALY FS++ +V+K+++ +TSSGG ND +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 361 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 420
Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
TFSH R+CL+R ++ +RYPP SP ++
Sbjct: 421 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 451
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 471 bits (1211), Expect = e-133
Identities = 233/451 (51%), Positives = 309/451 (68%), Gaps = 38/451 (8%)
Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
M + + ++R R AF +GRTRP +FR QL+ L R +QE +Q L ALA DLHK
Sbjct: 1 MDPLGDTLRRLREAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHK------ 54
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
TQ D +I EP G+VL+I WNYP NL
Sbjct: 55 -------------------------------ATQLDSAFIRKEPFGLVLIIAPWNYPLNL 83
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
T+ P+VGA+AAGN VVLKPSE+S+N+ +LA ++PQY+D+ + V+ GG ET +LL+ R
Sbjct: 84 TLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR 143
Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
FD+I +TGS VGKI+MTAAAKHLTPVTLELGGK+PCYVD NCD R+AW ++ N+
Sbjct: 144 FDYIFFTGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRVAWFRYFNA 203
Query: 241 GQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEG 300
GQTCVAPDY+LC P +Q +++ L+ ++ FYG+D + S + GRII+ + FQR+ L+
Sbjct: 204 GQTCVAPDYVLCSPEMQERLLPALQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGC 263
Query: 301 QKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREK 360
+VA GG D + RYIAPT+L DV PVMQEEIFGP+LPIV V+SL+EAI+FIN+REK
Sbjct: 264 GRVAIGGQSDESDRYIAPTVLVDVQEMEPVMQEEIFGPILPIVNVQSLDEAIEFINRREK 323
Query: 361 PLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFE 420
PLALY FS++ +V+K+++ +TSSGG ND +H+TL SLPFGGVG SGMG YHGK SF+
Sbjct: 324 PLALYAFSNSSQVVKRVLTQTSSGGFCGNDGFMHMTLASLPFGGVGASGMGRYHGKFSFD 383
Query: 421 TFSHRRSCLVRPLMNDEGLKVRYPP-SPAKM 450
TFSH R+CL+R ++ +RYPP SP ++
Sbjct: 384 TFSHHRACLLRSPGMEKLNALRYPPQSPRRL 414
>gi|73695881 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 407 bits (1045), Expect = e-113
Identities = 191/362 (52%), Positives = 263/362 (72%)
Query: 84 DEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELS 143
DEP + D ++I EP G+VL+I WNYP NLT+ +VGA+AAG+ VVLKPSE+S
Sbjct: 3 DEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEIS 62
Query: 144 ENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKH 203
+ +LA ++PQYLD+ + V+ GG ET +LL+ + D+I +TGS VGKI+MTAA KH
Sbjct: 63 QGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKH 122
Query: 204 LTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK 263
LTPVTLELGGK+PCYVD NCD R+AW + N+GQTCVAPDY+LC P +Q +++
Sbjct: 123 LTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPA 182
Query: 264 LKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTD 323
L+ ++ FYG+D + S + GRII+ + FQR+ L+ +VA GG + + RYIAPT+L D
Sbjct: 183 LQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVD 242
Query: 324 VDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSS 383
V PVMQEEIFGP+LPIV V+S++EAI+FIN++EKPLALY FS++ +V+ +M+ TSS
Sbjct: 243 VQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSS 302
Query: 384 GGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRY 443
G N+ +I+L S+PFGGVG+SGMG YHGK +F+TFSH R+CL+ P ++ ++ Y
Sbjct: 303 GSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEIHY 362
Query: 444 PP 445
PP
Sbjct: 363 PP 364
>gi|73695879 aldehyde dehydrogenase 3B2 [Homo sapiens]
Length = 385
Score = 407 bits (1045), Expect = e-113
Identities = 191/362 (52%), Positives = 263/362 (72%)
Query: 84 DEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELS 143
DEP + D ++I EP G+VL+I WNYP NLT+ +VGA+AAG+ VVLKPSE+S
Sbjct: 3 DEPRSTNLFMKLDSVFIWKEPFGLVLIIAPWNYPLNLTLVLLVGALAAGSCVVLKPSEIS 62
Query: 144 ENMASLLATIIPQYLDKDLYPVINGGVPETTELLKERFDHILYTGSTGVGKIIMTAAAKH 203
+ +LA ++PQYLD+ + V+ GG ET +LL+ + D+I +TGS VGKI+MTAA KH
Sbjct: 63 QGTEKVLAEVLPQYLDQSCFAVVLGGPQETGQLLEHKLDYIFFTGSPRVGKIVMTAATKH 122
Query: 204 LTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK 263
LTPVTLELGGK+PCYVD NCD R+AW + N+GQTCVAPDY+LC P +Q +++
Sbjct: 123 LTPVTLELGGKNPCYVDDNCDPQTVANRVAWFCYFNAGQTCVAPDYVLCSPEMQERLLPA 182
Query: 264 LKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLIEGQKVAYGGTGDAATRYIAPTILTD 323
L+ ++ FYG+D + S + GRII+ + FQR+ L+ +VA GG + + RYIAPT+L D
Sbjct: 183 LQSTITRFYGDDPQSSPNLGRIINQKQFQRLRALLGCGRVAIGGQSNESDRYIAPTVLVD 242
Query: 324 VDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSS 383
V PVMQEEIFGP+LPIV V+S++EAI+FIN++EKPLALY FS++ +V+ +M+ TSS
Sbjct: 243 VQETEPVMQEEIFGPILPIVNVQSVDEAIKFINRQEKPLALYAFSNSSQVVNQMLERTSS 302
Query: 384 GGVAANDVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVRPLMNDEGLKVRY 443
G N+ +I+L S+PFGGVG+SGMG YHGK +F+TFSH R+CL+ P ++ ++ Y
Sbjct: 303 GSFGGNEGFTYISLLSVPFGGVGHSGMGRYHGKFTFDTFSHHRTCLLAPSGLEKLKEIHY 362
Query: 444 PP 445
PP
Sbjct: 363 PP 364
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 161 bits (407), Expect = 1e-39
Identities = 126/444 (28%), Positives = 210/444 (47%), Gaps = 24/444 (5%)
Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
+++ AV+ A+AAF + R + L R+I+E+E E+ + K+ + A +
Sbjct: 74 EVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLD 133
Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTI 122
++ ++ AA E Y EPLGV + IG WNYPF +
Sbjct: 134 -----IDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIAS 188
Query: 123 QPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERF 181
A+A GN++V KPS + A LLA I + + L+ V+ GG T + L +
Sbjct: 189 WKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFLCQHP 247
Query: 182 D--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
D + +TGS G IM +AK + PVTLELGGKSP + +CD++ A + F+
Sbjct: 248 DVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLT 307
Query: 240 SGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQRVMGLI 298
GQ C + I ++ E++ K + G+ + G +I+ H +RV+G +
Sbjct: 308 QGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFV 367
Query: 299 -----EGQKVAYGG----TGDAATR---YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVR 346
+G KV GG D + Y+ P +LT+ ++EEIFGPV+ I+
Sbjct: 368 KVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFD 427
Query: 347 SLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVG 406
+ E ++ N LA +F+ + + +++AE +G N+ +++ LPFGG
Sbjct: 428 TEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINN--YNVSPVELPFGGYK 485
Query: 407 NSGMGSYHGKKSFETFSHRRSCLV 430
SG G +G+ + E +S ++ V
Sbjct: 486 KSGFGRENGRVTIEYYSQLKTVCV 509
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 159 bits (403), Expect = 4e-39
Identities = 120/442 (27%), Positives = 206/442 (46%), Gaps = 20/442 (4%)
Query: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
+ +AV+ A+ AF G R R + L L L++ L D K +A+
Sbjct: 71 VDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDTGKPFLHAF 130
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
+ ++ + + Y WA + P + EP+GV I WN+P +
Sbjct: 131 FIDLEGCIRTLRYFAG----WADKIQGKTIPTDDNVVCFTRHEPIGVCGAITPWNFPLLM 186
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
+ + A+ GN++VLKP+E + A L ++I + + ++ G P +
Sbjct: 187 LVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISS 246
Query: 180 --RFDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
+ + I +TGST VGK++ AA++ +L VTLELGGK+PC V + DLD+A G
Sbjct: 247 HPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDLAVECAHQGV 306
Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
F N GQ C A + + + ++ V + ++ + K G+ + G I + F +++
Sbjct: 307 FFNQGQCCTAASRVFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKIL 366
Query: 296 GLI-----EGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349
LI EG K+ GG+ + +I PT+ ++V + +EEIFGPV PI+ +S+E
Sbjct: 367 ELIESGKKEGAKLECGGSAMEDKGLFIKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIE 426
Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSG 409
E I+ N + L +F+ N K+ + SG V N + PFGG SG
Sbjct: 427 EVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWIN--CYNALYAQAPFGGFKMSG 484
Query: 410 MGSYHGKKSFETFSHRRSCLVR 431
G G+ + ++ ++ ++
Sbjct: 485 NGRELGEYALAEYTEVKTVTIK 506
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 152 bits (385), Expect = 5e-37
Identities = 133/447 (29%), Positives = 209/447 (46%), Gaps = 30/447 (6%)
Query: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
+ +AVK AR AF G RT R + L L LI+ L + + K NAY
Sbjct: 60 VDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAY 119
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
++ ++ + Y WA P Y EP+GV I WN+P +
Sbjct: 120 LNDLAGCIKTLRYCAG----WADKIQGRTIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVM 175
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
I + A++ GN+VV+KP+E + A +A++I + + ++ G P +
Sbjct: 176 LIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISS 235
Query: 180 RFD--HILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
D + +TGST VGK+I AA K +L VTLELGGKSPC V + DLD A G
Sbjct: 236 HMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDNAVEFAHHGV 295
Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
F + GQ C+A I + SI ++ V + ++++ K G G I + +++
Sbjct: 296 FYHQGQCCIAASRIFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQIDKEQYDKIL 355
Query: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
LI EG K+ GG G + ++ PT+ ++V + + +EEIFGPV I+ +SL
Sbjct: 356 DLIESGKKEGAKLECGG-GPWGNKGYFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSL 414
Query: 349 EEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAANDVIVH---ITLHSLPFGG 404
++ I+ N L+ +F+ + DK I T S + A V V+ + PFGG
Sbjct: 415 DDVIKRANNTFYGLSAGVFTKDIDKAI------TISSALQAGTVWVNCYGVVSAQCPFGG 468
Query: 405 VGNSGMGSYHGKKSFETFSHRRSCLVR 431
SG G G+ F ++ ++ V+
Sbjct: 469 FKMSGNGRELGEYGFHEYTEVKTVTVK 495
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 152 bits (384), Expect = 6e-37
Identities = 131/454 (28%), Positives = 214/454 (47%), Gaps = 38/454 (8%)
Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
+I AVK AR AF S +R Q R + L + L+++ +E A + D K A
Sbjct: 46 EIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALAR-- 103
Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL----YIHSEPLGVVLVIGTWNYPF 118
+I +Q +A+ + TQ D L Y P+GV +I WN P
Sbjct: 104 -----TMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPL 158
Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPET 173
L + A+AAGN+V+ KPSEL+ S+ A ++ + LDK P ++ G P
Sbjct: 159 YLLTWKIAPAMAAGNTVIAKPSELT----SVTAWMLCKLLDKAGVPPGVVNIVFGTGPRV 214
Query: 174 TELLKERFDH--ILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231
E L + I +TGS + I +A H ++LELGGK+P + ++ +LD
Sbjct: 215 GEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPA 274
Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARH 290
F N G+ C+ I SI ++ +++ ++ +++ G + G +IS H
Sbjct: 275 TVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALISKAH 334
Query: 291 FQRVMG-----LIEGQKVAYGGTGDA--------ATRYIAPTILTDVDPQSPVMQEEIFG 337
++V L EG ++ G D A ++ PT++TD+ +S M EEIFG
Sbjct: 335 LEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFG 394
Query: 338 PVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITL 397
PV +V S EE I+ N + LA ++SSN + ++ + SG V N ++
Sbjct: 395 PVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIREL- 453
Query: 398 HSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431
+LPFGG+ +SG+G K S++ F+ ++ V+
Sbjct: 454 -NLPFGGMKSSGIGREGAKDSYDFFTEIKTITVK 486
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 147 bits (371), Expect = 2e-35
Identities = 123/440 (27%), Positives = 199/440 (45%), Gaps = 16/440 (3%)
Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63
+ AVK AR AF G ++ L RL E++ V + + N + E
Sbjct: 76 VDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVYLASLETLDNG-KPFQES 134
Query: 64 VVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQ 123
L+E+ + + WA + P Q + EP+GV I WN+P +
Sbjct: 135 YALDLDEVIKVYRYFAGWADKWHGKTIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGW 194
Query: 124 PMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKERFD 182
+ A+A GN+VV+K +E + A LA++I + + +I G P + + D
Sbjct: 195 KLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVD 254
Query: 183 --HILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
+ +TGST VG +I AA +L VTLELGGKSP V + D++ A + F N
Sbjct: 255 VDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLADADMEHAVEQCHEALFFN 314
Query: 240 SGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298
GQ C A + SI N+ +E+ ++K+ + G + G + F+RV+G I
Sbjct: 315 MGQCCCAGSRTFVEESIYNEFLERTVEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYI 374
Query: 299 -----EGQKVAYGGT--GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
EG K+ GG G+ +I PT+ V + +EEIFGPV P+ + +EE
Sbjct: 375 QLGQKEGAKLLCGGERFGERGF-FIKPTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEV 433
Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411
++ N LA +F+ + +G V N + +T H+ PFGG SG G
Sbjct: 434 VERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVNTYNI-VTCHT-PFGGFKESGNG 491
Query: 412 SYHGKKSFETFSHRRSCLVR 431
G+ + ++ ++ ++
Sbjct: 492 RELGEDGLKAYTEVKTVTIK 511
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 145 bits (366), Expect = 7e-35
Identities = 122/443 (27%), Positives = 205/443 (46%), Gaps = 22/443 (4%)
Query: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
I +AV+ AR AFS G R R + L+ L L++ L + + K A+
Sbjct: 77 IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAF 136
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Y ++ V++ Y WA P + EP+GV I WN+P +
Sbjct: 137 YVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLM 192
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLKE 179
+ A+ GN+VV+KP+E + A + +I + + ++ G P +
Sbjct: 193 FAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAIAS 252
Query: 180 RF--DHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
D I +TGST VGK+I AA + +L VTLELGGKSP + + DLD A + G
Sbjct: 253 HIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGV 312
Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
F N GQ C A I + SI + V + ++++ + G + + G I + + +++
Sbjct: 313 FFNQGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKIL 372
Query: 296 -----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLE 349
G+ EG K+ GG G +I PT+ ++V + +EEIFGPV I+ ++++
Sbjct: 373 ELIQSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMD 432
Query: 350 EAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNS 408
E I+ N + L +F+++ I K + +S+ + + L++ PFGG S
Sbjct: 433 EVIERANNSDFGLVAAVFTND---INKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMS 489
Query: 409 GMGSYHGKKSFETFSHRRSCLVR 431
G G G+ +S ++ V+
Sbjct: 490 GNGREMGEFGLREYSEVKTVTVK 512
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 144 bits (364), Expect = 1e-34
Identities = 125/443 (28%), Positives = 198/443 (44%), Gaps = 22/443 (4%)
Query: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
+ +AVK ARAAF G R R + L L LI+ L D K +Y
Sbjct: 76 VDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISY 135
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
++ VL+ + Y WA + P Y EP+GV I WN+P +
Sbjct: 136 LVDLDMVLKCLRYYAG----WADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLM 191
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTELLK- 178
+ A+A GN VV+K +E + A +A +I + + ++ G P +
Sbjct: 192 QAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIAS 251
Query: 179 -ERFDHILYTGSTGVGKIIMTAA-AKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
E D + +TGST +G++I AA + +L VTLELGGKSP + + D+D A + +
Sbjct: 252 HEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFAL 311
Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM 295
F N GQ C A I ++ VE+ + ++ G + G + F++++
Sbjct: 312 FFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTEQGPQVDETQFKKIL 371
Query: 296 GLI-----EGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
G I EG K+ GG G AA R +I PT+ DV + +EEIFGPV+ I+ +++
Sbjct: 372 GYINTGKQEGAKLLCGG-GIAADRGYFIQPTVFGDVQDGMTIAKEEIFGPVMQILKFKTI 430
Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408
EE + N LA +F+ + + +G V N + PFGG S
Sbjct: 431 EEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVN--CYDVFGAQSPFGGYKMS 488
Query: 409 GMGSYHGKKSFETFSHRRSCLVR 431
G G G+ + ++ ++ V+
Sbjct: 489 GSGRELGEYGLQAYTEVKTVTVK 511
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 143 bits (361), Expect = 3e-34
Identities = 116/437 (26%), Positives = 205/437 (46%), Gaps = 17/437 (3%)
Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQ--LEALQRLIQEQEQELVGALAADLHKNEWN 58
++ + +AV A+ AF +G + R + + L L++E ++EL A D
Sbjct: 479 LADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTL 538
Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118
A + ++ Y + + ++ + EPLGV +I WNYP
Sbjct: 539 ALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPL 598
Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177
+ +AAGN++VLKP++++ A A + + K + +I G + L
Sbjct: 599 MMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRL 658
Query: 178 KERFD--HILYTGSTGVGKIIM-TAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234
E D + +TGST +GK IM + A +L V+LELGGKSP + +C+LD A R
Sbjct: 659 SEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMG 718
Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293
F N G+ C+A + + SI ++ V ++ + +K+ G+ +S D+G H ++
Sbjct: 719 AVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEK 778
Query: 294 VM-----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRS 347
++ G+ EG + YGG ++ PT+ TDV+ + +EE FGP++ I ++
Sbjct: 779 LLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQN 838
Query: 348 --LEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405
++ +Q N E LA +F+ + + + +G V N + T + PFGGV
Sbjct: 839 GDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFIN--TYNKTDVAAPFGGV 896
Query: 406 GNSGMGSYHGKKSFETF 422
SG G G+++ +
Sbjct: 897 KQSGFGKDLGEEALNEY 913
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 136 bits (343), Expect = 3e-32
Identities = 111/414 (26%), Positives = 191/414 (46%), Gaps = 19/414 (4%)
Query: 30 LEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVYVLEEIEYMIQKLPEWAADEPVEK 89
L+ L L++ L + + K A+Y ++ V++ Y WA
Sbjct: 10 LDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAG----WADKIHGMT 65
Query: 90 TPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASL 149
P + EP+GV I WN+P + + A+ GN+VV+KP+E + A
Sbjct: 66 IPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALY 125
Query: 150 LATIIPQY-LDKDLYPVINGGVPETTELLKERF--DHILYTGSTGVGKIIMTAAAK-HLT 205
+ +I + + ++ G P + D I +TGST VGK+I AA + +L
Sbjct: 126 MGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSNLK 185
Query: 206 PVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEK-L 264
VTLELGGKSP + + DLD A + G F N GQ C A I + SI + V + +
Sbjct: 186 RVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSV 245
Query: 265 KKSLKEFYGEDAKKSRDYGRIISARHFQRVM-----GLIEGQKVAYGGTG-DAATRYIAP 318
+++ + G + + G I + + +++ G+ EG K+ GG G +I P
Sbjct: 246 ERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEP 305
Query: 319 TILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMI 378
T+ ++V + +EEIFGPV I+ ++++E I+ N + L +F+++ I K +
Sbjct: 306 TVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTND---INKAL 362
Query: 379 AETSSGGVAANDVIVHITLHS-LPFGGVGNSGMGSYHGKKSFETFSHRRSCLVR 431
+S+ + + L++ PFGG SG G G+ +S ++ V+
Sbjct: 363 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREYSEVKTVTVK 416
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 136 bits (342), Expect = 4e-32
Identities = 120/432 (27%), Positives = 197/432 (45%), Gaps = 24/432 (5%)
Query: 7 AVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVY 66
AV+ A AF R + R L L+ + + +L + A+ K A+ E++Y
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILY 159
Query: 67 VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 126
+E+ ++ D + TP + L + +P+GV VI WN+P + + +
Sbjct: 160 SAFFLEWFSEEARRVYGD--IIHTPAKDRRALVL-KQPIGVAAVITPWNFPSAMITRKVG 216
Query: 127 GAIAAGNSVVLKPSELSENMASLLATIIPQY-LDKDLYPVINGGVPETTEL-----LKER 180
A+AAG +VV+KP+E + A LA + Q + +Y VI E+
Sbjct: 217 AALAAGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSRKNAKEVGEAICTDPL 276
Query: 181 FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMNS 240
I +TGST GKI++ AA + V++ELGG +P V + ++D A KF N+
Sbjct: 277 VSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVDQAVAGAMASKFRNT 336
Query: 241 GQTCVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVM- 295
GQTCV + L I + V E +KK+L+ G ++ G +I+ + ++V
Sbjct: 337 GQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQGPLINEKAVEKVEK 394
Query: 296 ----GLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEE 350
+ +G V GG + PT+L +V EE FGP+ P++ + EE
Sbjct: 395 QVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETFGPLAPVIKFDTEEE 454
Query: 351 AIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGM 410
AI N + LA Y +S + I ++ + G V N+ + I+ PFGGV SG+
Sbjct: 455 AIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--ISSVECPFGGVKQSGL 512
Query: 411 GSYHGKKSFETF 422
G K + +
Sbjct: 513 GREGSKYGIDEY 524
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 134 bits (337), Expect = 2e-31
Identities = 123/446 (27%), Positives = 203/446 (45%), Gaps = 39/446 (8%)
Query: 7 AVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEEVVY 66
AV+ A AF R + R L L+ + + +L + A+ K A+ E++Y
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAH-GEILY 159
Query: 67 VLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNLTIQPMV 126
+E+ ++ D + TP + L + +P+GV VI WN+P + + +
Sbjct: 160 SAFFLEWFSEEARRVYGD--IIHTPAKDRRALVL-KQPIGVAAVITPWNFPSAMITRKVG 216
Query: 127 GAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVI---NGGVPE--------TTE 175
A+AAG +VV+KP+E + A LA + +L DL P++ G+P + +
Sbjct: 217 AALAAGCTVVVKPAEDTPFSALALAEVNQGFL-LDLDPLLLASQAGIPSGVYNVIPCSRK 275
Query: 176 LLKE---------RFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLD 226
KE I +TGST GKI++ AA + V++ELGG +P V + ++D
Sbjct: 276 NAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFDSANVD 335
Query: 227 VACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIV----EKLKKSLKEFYGEDAKKSRDY 282
A KF N+GQTCV + L I + V E +KK+L+ G ++
Sbjct: 336 QAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLR--VGNGFEEGTTQ 393
Query: 283 GRIISARHFQRVM-----GLIEGQKVAYGG-TGDAATRYIAPTILTDVDPQSPVMQEEIF 336
G +I+ + ++V + +G V GG + PT+L +V EE F
Sbjct: 394 GPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHEETF 453
Query: 337 GPVLPIVCVRSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHIT 396
GP+ P++ + EEAI N + LA Y +S + I ++ + G V N+ + I+
Sbjct: 454 GPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGL--IS 511
Query: 397 LHSLPFGGVGNSGMGSYHGKKSFETF 422
PFGGV SG+G K + +
Sbjct: 512 SVECPFGGVKQSGLGREGSKYGIDEY 537
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 126 bits (317), Expect = 4e-29
Identities = 114/440 (25%), Positives = 192/440 (43%), Gaps = 54/440 (12%)
Query: 4 ISEAVKRARAAFSSG---RTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAY 60
I +AV+ AR AFS G R R + L+ L L++ L + + K A+
Sbjct: 77 IDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAF 136
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
Y ++ V++ Y WA P + EP+GV I WN+P +
Sbjct: 137 YVDLQGVIKTFRYYAG----WADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLM 192
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
+ A+ GN+VV+KP+E + A + +I +
Sbjct: 193 FAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKE------------------------ 228
Query: 181 FDHILYTGSTGVGKIIMTAAAK-HLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFMN 239
VGK+I AA + +L VTLELGGKSP + + DLD A + G F N
Sbjct: 229 -----------VGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFN 277
Query: 240 SGQTCVAPDYILCDPSIQNQIVEK-LKKSLKEFYGEDAKKSRDYGRIISARHFQRVM--- 295
GQ C A I + SI + V + ++++ + G + + G I + + +++
Sbjct: 278 QGQCCTAGSRIFVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELI 337
Query: 296 --GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEAI 352
G+ EG K+ GG G +I PT+ ++V + +EEIFGPV I+ ++++E I
Sbjct: 338 QSGVAEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVI 397
Query: 353 QFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHS-LPFGGVGNSGMG 411
+ N + L +F+++ I K + +S+ + + L++ PFGG SG G
Sbjct: 398 ERANNSDFGLVAAVFTND---INKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNG 454
Query: 412 SYHGKKSFETFSHRRSCLVR 431
G+ +S ++ V+
Sbjct: 455 REMGEFGLREYSEVKTVTVK 474
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 125 bits (313), Expect = 1e-28
Identities = 113/437 (25%), Positives = 196/437 (44%), Gaps = 17/437 (3%)
Query: 1 MSKISEAVKRARAAFSSGRTRPLQFRIQQ--LEALQRLIQEQEQELVGALAADLHKNEWN 58
++ + +AV A+ AF +GR + R + + L L+++ ++EL A D
Sbjct: 458 VTDVDKAVAAAKDAFENGRWGKISARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTL 517
Query: 59 AYYEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPF 118
A V ++ Y + + ++ EP+GV +I WNYP
Sbjct: 518 ALKTHVGMSIQTFRYFAGWCDKIQGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPL 577
Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATI-IPQYLDKDLYPVINGGVPETTELL 177
+ +AAGN+VV+KP++++ A A + + + K + V+ G + L
Sbjct: 578 MMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRL 637
Query: 178 KERFD--HILYTGSTGVGKIIMTAAA-KHLTPVTLELGGKSPCYVDKNCDLDVACRRIAW 234
+ D I +TGST VGK IM + A ++ V+LELGGKSP + +CDL+ A +
Sbjct: 638 SDHPDVRKIGFTGSTEVGKHIMKSCAISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMS 697
Query: 235 GKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDAKKSRDYGRIISARHFQR 293
F N G+ C+A + + SI ++ V ++ + +++ G + D+G H +
Sbjct: 698 SVFFNKGENCIAAGRLFVEDSIHDEFVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVK 757
Query: 294 VM-----GLIEGQKVAYGGTG-DAATRYIAPTILTDVDPQSPVMQEEIFGPVLPI--VCV 345
+M G+ EG + GG + PT+ TDV+ + +EE FGPV+ I
Sbjct: 758 LMEYCQHGVKEGATLVCGGNQVPRPGFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFAD 817
Query: 346 RSLEEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGV 405
L+ + N E LA +F+ + + + +G V N + T + PFGG
Sbjct: 818 GDLDAVLSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVN--TYNKTDVAAPFGGF 875
Query: 406 GNSGMGSYHGKKSFETF 422
SG G G+ + +
Sbjct: 876 KQSGFGKDLGEAALNEY 892
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 125 bits (313), Expect = 1e-28
Identities = 120/440 (27%), Positives = 193/440 (43%), Gaps = 64/440 (14%)
Query: 3 KISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYE 62
+I AVK AR AF S +R Q R + L + L+++ +E A + D K A
Sbjct: 46 EIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALAR-- 103
Query: 63 EVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDEL----YIHSEPLGVVLVIGTWNYPF 118
+I +Q +A+ + TQ D L Y P+GV +I WN P
Sbjct: 104 -----TMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPL 158
Query: 119 NLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYP-----VINGGVPET 173
L + A+AAGN+V+ KPSEL+ S+ A ++ + LDK P ++ G P
Sbjct: 159 YLLTWKIAPAMAAGNTVIAKPSELT----SVTAWMLCKLLDKAGVPPGVVNIVFGTGPRV 214
Query: 174 TELL--KERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRR 231
E L I +TGS + I +A H ++LELGGK+P + ++ +LD
Sbjct: 215 GEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPA 274
Query: 232 IAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHF 291
F N +++ + L + + + GE K
Sbjct: 275 TVRSSFAN---------------QVRSYVKRALAEGAQIWCGEGVDK------------- 306
Query: 292 QRVMGLIEGQKVAYGGTGDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
+ L + Y ++ PT++TD+ +S M EEIFGPV +V S EE
Sbjct: 307 ---LSLPARNQAGY---------FMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEV 354
Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNSGMG 411
I+ N + LA ++SSN + ++ + SG V N ++ +LPFGG+ +SG+G
Sbjct: 355 IERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIREL--NLPFGGMKSSGIG 412
Query: 412 SYHGKKSFETFSHRRSCLVR 431
K S++ F+ ++ V+
Sbjct: 413 REGAKDSYDFFTEIKTITVK 432
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 103 bits (256), Expect = 4e-22
Identities = 103/441 (23%), Positives = 188/441 (42%), Gaps = 21/441 (4%)
Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYY 61
+++ A+ + AF + + R Q L Q+LI+E +E+ + + K +A
Sbjct: 77 AEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAE- 135
Query: 62 EEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQD-ELYIHSEPLGVVLVIGTWNYPFNL 120
+V L+ +E+ E P +D +LY + PLGV I +N+P +
Sbjct: 136 GDVFRGLQVVEHACSVTSLMMG----ETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI 191
Query: 121 TIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELLKER 180
+ A+ GN+ ++KPSE LLA ++ D I G E + +
Sbjct: 192 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNFICDH 251
Query: 181 FD--HILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGKFM 238
D I + GS G+ I ++H V +G K+ V + + + ++ F
Sbjct: 252 PDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAFG 311
Query: 239 NSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGRIISARHFQRVMGLI 298
+GQ C+A + + + E ++ + + D G +I+ + +RV LI
Sbjct: 312 AAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVCNLI 371
Query: 299 -----EGQKVAYGGT-----GDAATRYIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSL 348
EG + G G ++ PTI+++V P +EEIFGPVL ++ +L
Sbjct: 372 DSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLVVLETETL 431
Query: 349 EEAIQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLHSLPFGGVGNS 408
+EAIQ +N +F++N +K G V N V + + L F G +S
Sbjct: 432 DEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVN-VPIPVPLPMFSFTGSRSS 490
Query: 409 GMG--SYHGKKSFETFSHRRS 427
G +++GK+ + ++ ++
Sbjct: 491 FRGDTNFYGKQGIQFYTQLKT 511
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 92.0 bits (227), Expect = 1e-18
Identities = 78/341 (22%), Positives = 153/341 (44%), Gaps = 14/341 (4%)
Query: 104 PLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSELSENMASLLATIIPQYLDKDLY 163
P+G+V +I +N+P + A+ GN + K + + ++ + II + L+ +
Sbjct: 184 PVGLVGIITAFNFPVAVYGWNNAIAMICGNVCLWKGAPTTSLISVAVTKIIAKVLEDNKL 243
Query: 164 P-----VINGGVPETTELLK-ERFDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPC 217
P + GG T + K ER + + +TGST VGK + + LELGG +
Sbjct: 244 PGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERFGRSLLELGGNNAI 303
Query: 218 YVDKNCDLDVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEF-YGEDA 276
++ DL + + +GQ C + SI +++V +LKK+ + G
Sbjct: 304 IAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRLKKAYAQIRVGNPW 363
Query: 277 KKSRDYGRIISARHFQRVMGLI-----EGQKVAYGG-TGDAATRYIAPTILTDVDPQSPV 330
+ YG + + + +G + EG V YGG D Y+ PTI+T + + +
Sbjct: 364 DPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKVMDRPGNYVEPTIVTGLGHDASI 423
Query: 331 MQEEIFGPVLPIVCVRSLEEAIQFINQREKPLALYMFSSN-DKVIKKMIAETSSGGVAAN 389
E F P+L + ++ EE + N+ ++ L+ +F+ + ++ + + + S G+
Sbjct: 424 AHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNV 483
Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHGKKSFETFSHRRSCLV 430
++ FGG ++G G G +++ + R +C +
Sbjct: 484 NIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTI 524
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 78.6 bits (192), Expect = 1e-14
Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)
Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60
S +++A++ A AA +P+ R Q L+A L + E++ K A
Sbjct: 100 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 159
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
+ +++ + + E +P+ P T ++ G V I PFN
Sbjct: 160 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 212
Query: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
T + GA A GN V+ KPS+ + + + I+ + L P I VP L
Sbjct: 213 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 269
Query: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225
E I +TGS K + A++L + E GGK+ +V ++ D+
Sbjct: 270 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 329
Query: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284
+ F GQ C A + S+ QI +L + D + D+G
Sbjct: 330 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 387
Query: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334
+I A+ F R+ +E + +A G D+ ++ P I+ DPQ P+M+EE
Sbjct: 388 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 447
Query: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389
IFGPVL + +E +Q ++ L +FS + V+++ + ++G N
Sbjct: 448 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 507
Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415
D + PFGG SG G
Sbjct: 508 DKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 78.6 bits (192), Expect = 1e-14
Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)
Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60
S +++A++ A AA +P+ R Q L+A L + E++ K A
Sbjct: 40 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 99
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
+ +++ + + E +P+ P T ++ G V I PFN
Sbjct: 100 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 152
Query: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
T + GA A GN V+ KPS+ + + + I+ + L P I VP L
Sbjct: 153 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 209
Query: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225
E I +TGS K + A++L + E GGK+ +V ++ D+
Sbjct: 210 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 269
Query: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284
+ F GQ C A + S+ QI +L + D + D+G
Sbjct: 270 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 327
Query: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334
+I A+ F R+ +E + +A G D+ ++ P I+ DPQ P+M+EE
Sbjct: 328 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 387
Query: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389
IFGPVL + +E +Q ++ L +FS + V+++ + ++G N
Sbjct: 388 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 447
Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415
D + PFGG SG G
Sbjct: 448 DKSTGSIVGQQPFGGARASGTNDKPG 473
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 78.6 bits (192), Expect = 1e-14
Identities = 106/446 (23%), Positives = 178/446 (39%), Gaps = 44/446 (9%)
Query: 2 SKISEAVKRARAAFSSGRTRPLQFRIQQ-LEALQRLIQEQEQELVGALAADLHKNEWNAY 60
S +++A++ A AA +P+ R Q L+A L + E++ K A
Sbjct: 100 SLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKTMVGQGKTVIQAE 159
Query: 61 YEEVVYVLEEIEYMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFNL 120
+ +++ + + E +P+ P T ++ G V I PFN
Sbjct: 160 IDAAAELIDFFRFNAKYAVELEGQQPISVPPSTNST---VYRGLEGFVAAIS----PFNF 212
Query: 121 TI--QPMVGAIAA-GNSVVLKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
T + GA A GN V+ KPS+ + + + I+ + L P I VP L
Sbjct: 213 TAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILRE---AGLPPNIIQFVPADGPLF 269
Query: 178 ------KERFDHILYTGSTGVGKIIMTAAAKHLTP------VTLELGGKSPCYVDKNCDL 225
E I +TGS K + A++L + E GGK+ +V ++ D+
Sbjct: 270 GDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGECGGKNFHFVHRSADV 329
Query: 226 DVACRRIAWGKFMNSGQTCVAPDYILCDPSIQNQIVEKLKKSLKEFYGEDAKKSRDYGR- 284
+ F GQ C A + S+ QI +L + D + D+G
Sbjct: 330 ESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRIKVGDP--AEDFGTF 387
Query: 285 ---IISARHFQRVMGLIEGQK-------VAYGGTGDAATRYIAPTILTDVDPQSPVMQEE 334
+I A+ F R+ +E + +A G D+ ++ P I+ DPQ P+M+EE
Sbjct: 388 FSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPCIVESKDPQEPIMKEE 447
Query: 335 IFGPVLPIVCV--RSLEEAIQFINQREK-PLALYMFSSNDKVIKK--MIAETSSGGVAAN 389
IFGPVL + +E +Q ++ L +FS + V+++ + ++G N
Sbjct: 448 IFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQEATKVLRNAAGNFYIN 507
Query: 390 DVIVHITLHSLPFGGVGNSGMGSYHG 415
D + PFGG SG G
Sbjct: 508 DKSTGSIVGQQPFGGARASGTNDKPG 533
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 46.2 bits (108), Expect = 6e-05
Identities = 87/429 (20%), Positives = 166/429 (38%), Gaps = 48/429 (11%)
Query: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63
++ AV+ AR AF P R Q L L +IQ+ ++ L W
Sbjct: 79 VAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLL------------WTLESLV 126
Query: 64 VVYVLEEIE----YMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119
+ E+ + Q+L + A + + Q+E EP+GV+ +I + F
Sbjct: 127 TGRAVREVRDGDVQLAQQLLHYHAIQA------STQEEALAGWEPMGVIGLILPPTFSFL 180
Query: 120 LTIQPMVGAIAAGNSVV--LKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
+ + A+A G +VV + P+ + + + LA + + + V++G L
Sbjct: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPF--PGILNVLSGPASLVPILA 238
Query: 178 KER-FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
+ + + G+ G+ + + A + L LG +S + D+D A +
Sbjct: 239 SQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAA 298
Query: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKS---LKEFYGEDAKKSRDYGRIISARHFQR 293
+ + G + +L S+ ++ + +L++ L+ G D + QR
Sbjct: 299 WSDRGPGGLR---LLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQR 355
Query: 294 VMGLIEGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
+ + Q GD + + PT+++++ P SP Q E+ PV+ R+ +EA
Sbjct: 356 FVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEA 415
Query: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH-----SLPFGGVG 406
+ N + + V + + + G V I H S+P GG
Sbjct: 416 LLVANGTPR-------GGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCK 468
Query: 407 NSGMGSYHG 415
SG S+HG
Sbjct: 469 ESGC-SWHG 476
Score = 37.7 bits (86), Expect = 0.022
Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 10/116 (8%)
Query: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSE----LSENMASLLATIIPQYL 158
EPLGV+ V+ +P + + A+A GN+VV+ PS L+ + +AT+ P
Sbjct: 659 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFP--- 715
Query: 159 DKDLYPVINGGVPETTELLKERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELG 212
L V+ G T L D + Y GS + + A+A +L PV G
Sbjct: 716 -AGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 770
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,281,236
Number of Sequences: 37866
Number of extensions: 781051
Number of successful extensions: 2250
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2149
Number of HSP's gapped (non-prelim): 56
length of query: 453
length of database: 18,247,518
effective HSP length: 106
effective length of query: 347
effective length of database: 14,233,722
effective search space: 4939101534
effective search space used: 4939101534
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.