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Search of human proteins with 22749211
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749211 transmembrane and tetratricopeptide repeat
containing 2 [Homo sapiens]
(836 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749211 transmembrane and tetratricopeptide repeat containin... 1686 0.0
gi|118766328 transmembrane and tetratricopeptide repeat containi... 377 e-104
gi|118766330 transmembrane and tetratricopeptide repeat containi... 377 e-104
gi|224809432 transmembrane and tetratricopeptide repeat containi... 329 7e-90
gi|83415184 transmembrane and tetratricopeptide repeat containin... 184 4e-46
gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens] 116 8e-26
gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens] 116 8e-26
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 59 2e-08
gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 55 3e-07
gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 55 3e-07
gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 55 3e-07
gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 53 1e-06
gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 53 1e-06
gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 52 2e-06
gi|41871960 kinesin-like 8 isoform b [Homo sapiens] 50 7e-06
gi|41871955 kinesin-like 8 isoform a [Homo sapiens] 50 7e-06
gi|41871946 kinesin-like 8 isoform a [Homo sapiens] 50 7e-06
gi|198041734 kinesin light chain 2 isoform 1 [Homo sapiens] 50 1e-05
gi|198041731 kinesin light chain 2 isoform 1 [Homo sapiens] 50 1e-05
gi|198041728 kinesin light chain 2 isoform 2 [Homo sapiens] 50 1e-05
gi|12383062 kinesin light chain 2 isoform 1 [Homo sapiens] 50 1e-05
gi|91825557 kinesin light chain 3 [Homo sapiens] 50 1e-05
gi|116534937 interferon-induced protein with tetratricopeptide r... 47 6e-05
gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo ... 46 1e-04
gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform... 45 3e-04
gi|167466177 cell division cycle protein 27 isoform 1 [Homo sapi... 45 3e-04
gi|167466175 cell division cycle protein 27 isoform 2 [Homo sapi... 45 3e-04
gi|54607135 translocase of outer mitochondrial membrane 70 homol... 44 6e-04
gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo... 44 6e-04
gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo... 44 6e-04
>gi|22749211 transmembrane and tetratricopeptide repeat containing 2
[Homo sapiens]
Length = 836
Score = 1686 bits (4365), Expect = 0.0
Identities = 836/836 (100%), Positives = 836/836 (100%)
Query: 1 MIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSG 60
MIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSG
Sbjct: 1 MIAELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSG 60
Query: 61 SHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAG 120
SHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAG
Sbjct: 61 SHKSYRPLCTLSFRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAG 120
Query: 121 LMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAG 180
LMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAG
Sbjct: 121 LMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAG 180
Query: 181 CSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLG 240
CSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLG
Sbjct: 181 CSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLG 240
Query: 241 ARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVP 300
ARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVP
Sbjct: 241 ARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVP 300
Query: 301 LLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEY 360
LLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEY
Sbjct: 301 LLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEY 360
Query: 361 QNSETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIA 420
QNSETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIA
Sbjct: 361 QNSETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIA 420
Query: 421 ERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNE 480
ERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNE
Sbjct: 421 ERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNE 480
Query: 481 EMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQEN 540
EMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQEN
Sbjct: 481 EMLYRSGIKVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQEN 540
Query: 541 SRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHA 600
SRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHA
Sbjct: 541 SRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHA 600
Query: 601 HKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLP 660
HKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLP
Sbjct: 601 HKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLP 660
Query: 661 EAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQF 720
EAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQF
Sbjct: 661 EAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQF 720
Query: 721 LLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPA 780
LLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPA
Sbjct: 721 LLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPA 780
Query: 781 ALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSKT 836
ALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSKT
Sbjct: 781 ALMNLGAILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSKT 836
>gi|118766328 transmembrane and tetratricopeptide repeat containing
4 isoform 2 [Homo sapiens]
Length = 741
Score = 377 bits (968), Expect = e-104
Identities = 249/787 (31%), Positives = 387/787 (49%), Gaps = 102/787 (12%)
Query: 3 AELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSH 62
A+LV ++ + + + DF +DDS AI N+DL ETP ++++DFWG+ L+ + SH
Sbjct: 22 AKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSH 81
Query: 63 KSYRPLCTLSFRLNHAI-GGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWT----- 116
KSYRPL L+FR+N+ + GG +P +H+VN+LLH+ ++ L +L G +T
Sbjct: 82 KSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRR 141
Query: 117 --------FMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIK---HCSTRGYS 165
+A L+FA HP+HTE VAG+VGRAD+ +LFFLLS L Y K + G
Sbjct: 142 LHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAH 201
Query: 166 ARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKR------ 219
+ T+ W L S +ML KEQG+TVL ++AV+D+ V + + +I+ + +
Sbjct: 202 SSTF-WVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNVLEIVQKVLHKDKSLEN 260
Query: 220 ----KNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFY 275
+N L ++LL G+ +L R MG PP+F+ DNPA+ +DS+L R + + Y
Sbjct: 261 LGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYNY 320
Query: 276 LPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDR 335
+ N WLLLCP L FDWSM +PL+K++ DWR + A + L+ L L S
Sbjct: 321 YYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCS----- 375
Query: 336 ECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIKNDVSQRTQLPSTENIVV 395
+GH I+
Sbjct: 376 -------------EDGHK-------------------------------------RRILT 385
Query: 396 LSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLI 455
L L L+IPF+PA+NLFF VGFV+AERVLY+PS+G+C+L+T G AL +K K LI
Sbjct: 386 LGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKK---KKLI 442
Query: 456 FYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKISEAE 513
++ L+ +R+G+W++EE L+RS + V P AK N+G L + + A
Sbjct: 443 AAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAI 502
Query: 514 SAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMN 573
YR A+ + NLG +L+E + EA LA+ +P A+A++N GI+
Sbjct: 503 RYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIV--- 559
Query: 574 QGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAI 633
+ LK E +++ + H+ C YNLG+LY + + +AL+ ++ A
Sbjct: 560 --------QNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNAT 611
Query: 634 QKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRK 693
P +N M L +AE E+L + + +L + +
Sbjct: 612 VLKPEH---SLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKY 668
Query: 694 SEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAH 753
E+E LFLKAI+ +P + + + L A + + + +LD T N
Sbjct: 669 KESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGL 728
Query: 754 MLRQASL 760
+ R+ L
Sbjct: 729 LRRKLEL 735
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/118 (24%), Positives = 60/118 (50%)
Query: 690 TGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVF 749
+G E+LF A+ + P + + G+ L ++ A ++A L+ +
Sbjct: 461 SGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMN 520
Query: 750 NAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQ 807
N ++L++ + + AE+ LA +++P++ AA MNLG + + R + AE +Y A++
Sbjct: 521 NLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIK 578
>gi|118766330 transmembrane and tetratricopeptide repeat containing
4 isoform 1 [Homo sapiens]
Length = 760
Score = 377 bits (968), Expect = e-104
Identities = 249/787 (31%), Positives = 387/787 (49%), Gaps = 102/787 (12%)
Query: 3 AELVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSH 62
A+LV ++ + + + DF +DDS AI N+DL ETP ++++DFWG+ L+ + SH
Sbjct: 41 AKLVVGSVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSH 100
Query: 63 KSYRPLCTLSFRLNHAI-GGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWT----- 116
KSYRPL L+FR+N+ + GG +P +H+VN+LLH+ ++ L +L G +T
Sbjct: 101 KSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRR 160
Query: 117 --------FMAGLMFASHPIHTEAVAGIVGRADVGASLFFLLSLLCYIK---HCSTRGYS 165
+A L+FA HP+HTE VAG+VGRAD+ +LFFLLS L Y K + G
Sbjct: 161 LHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAH 220
Query: 166 ARTWGWFLGSGLCAGCSMLWKEQGVTVLAVSAVYDVFVFHRLKIKQILPTIYKR------ 219
+ T+ W L S +ML KEQG+TVL ++AV+D+ V + + +I+ + +
Sbjct: 221 SSTF-WVLLSIFLGAVAMLCKEQGITVLGLNAVFDILVIGKFNVLEIVQKVLHKDKSLEN 279
Query: 220 ----KNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAADSDSLLTRTLTFFY 275
+N L ++LL G+ +L R MG PP+F+ DNPA+ +DS+L R + + Y
Sbjct: 280 LGMLRNGGLLFRMTLLTSGGAGMLYVRWRIMGTGPPAFTEVDNPASFADSMLVRAVNYNY 339
Query: 276 LPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDR 335
+ N WLLLCP L FDWSM +PL+K++ DWR + A + L+ L L S
Sbjct: 340 YYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWRVIALAALWFCLIGLICQALCS----- 394
Query: 336 ECNGKTVTNGKQNANGHSCLSDVEYQNSETKSSFASKVENGIKNDVSQRTQLPSTENIVV 395
+GH I+
Sbjct: 395 -------------EDGHK-------------------------------------RRILT 404
Query: 396 LSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKSLI 455
L L L+IPF+PA+NLFF VGFV+AERVLY+PS+G+C+L+T G AL +K K LI
Sbjct: 405 LGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVLLTFGFGALSKHTKK---KKLI 461
Query: 456 FYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKISEAE 513
++ L+ +R+G+W++EE L+RS + V P AK N+G L + + A
Sbjct: 462 AAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAI 521
Query: 514 SAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMN 573
YR A+ + NLG +L+E + EA LA+ +P A+A++N GI+
Sbjct: 522 RYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIV--- 578
Query: 574 QGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAI 633
+ LK E +++ + H+ C YNLG+LY + + +AL+ ++ A
Sbjct: 579 --------QNSLKRFEAAEQSYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALNAWRNAT 630
Query: 634 QKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRK 693
P +N M L +AE E+L + + +L + +
Sbjct: 631 VLKPEH---SLAWNNMIILLDNTGNLAQAEAVGREALELIPNDHSLMFSLANVLGKSQKY 687
Query: 694 SEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAH 753
E+E LFLKAI+ +P + + + L A + + + +LD T N
Sbjct: 688 KESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTKENYGL 747
Query: 754 MLRQASL 760
+ R+ L
Sbjct: 748 LRRKLEL 754
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/118 (24%), Positives = 60/118 (50%)
Query: 690 TGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVF 749
+G E+LF A+ + P + + G+ L ++ A ++A L+ +
Sbjct: 480 SGEWRSEEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMN 539
Query: 750 NAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQ 807
N ++L++ + + AE+ LA +++P++ AA MNLG + + R + AE +Y A++
Sbjct: 540 NLGNILKERNELQEAEELLSLAVQIQPDFAAAWMNLGIVQNSLKRFEAAEQSYRTAIK 597
>gi|224809432 transmembrane and tetratricopeptide repeat containing
3 [Homo sapiens]
Length = 914
Score = 329 bits (843), Expect = 7e-90
Identities = 254/848 (29%), Positives = 402/848 (47%), Gaps = 98/848 (11%)
Query: 13 ALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLCTLS 72
A Y N+L F +DD AI N+DL P TP +F NDFWGT ++ SHKSYRPL L+
Sbjct: 18 ACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLT 77
Query: 73 FRLNHAIGGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEA 132
FRLN+ + L P SYHL+N++ HA V+ +F K+ L D + +A L+FA HPIHTEA
Sbjct: 78 FRLNYLLSELKPMSYHLLNMIFHAVVSVIFLKVCKLFL-DNKSSVIASLLFAVHPIHTEA 136
Query: 133 VAGIVGRADVGASLFFLLSLLCYIKHCSTRGYSARTWGWFLGSGLCAGCSMLWKEQGVTV 192
V G+VGRA++ +S+FFL + L Y + S ++ W + + L KEQG+TV
Sbjct: 137 VTGVVGRAELLSSIFFLAAFLSYTR--SKGPDNSIIWTPIALTVFLVAVATLCKEQGITV 194
Query: 193 LAVSAVYDVFVFHRLKIKQILPT---IYKRKN------LSLFLSISLLIFWGSSLLGARL 243
+ + VY+VF+ + + T + K L + + +L+F L+ R+
Sbjct: 195 VGICCVYEVFIAQGYTLPLLCTTAGQFLRGKGSIPFSMLQTLVKLIVLMFSTLLLVVIRV 254
Query: 244 YWMGNKPPSFSNSDNPAADSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLK 303
+ ++ P F+ DNPAA S + TR LTF YL N WLLL P L DW+M +PL++
Sbjct: 255 QVIQSQLPVFTRFDNPAAVSPT-PTRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIE 313
Query: 304 TVCDWRNLHTVAFYTGLLLLAYYGLKSPSVDRECNGKTVTNGKQNANGHSCLSDVEYQNS 363
++ D RNL T F+ L +L + ++ Y
Sbjct: 314 SLLDIRNLATFTFFCFLGMLGVFSIR------------------------------YSGD 343
Query: 364 ETKSSFASKVENGIKNDVSQRTQLPSTENIVVLSLSLLIIPFVPATNLFFYVGFVIAERV 423
+K+ V+++L L+ +PF+PA+NLFF VGFV+AERV
Sbjct: 344 SSKT--------------------------VLMALCLMALPFIPASNLFFPVGFVVAERV 377
Query: 424 LYIPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEML 483
LY+PSMGFC+L+ G + + K K L + + +I+ + LKT RN DW++E L
Sbjct: 378 LYVPSMGFCILVAHGWQKIST---KSVFKKLSWICLSMVILTHSLKTFHRNWDWESEYTL 434
Query: 484 YRSGIKVNP--AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENS 541
+ S +KVN AK W N+G+ L+++ A + A + + + N+G + +
Sbjct: 435 FMSALKVNKNNAKLWNNVGHALENEKNFERALKYFLQATHVQPDDIGAHMNVGRTYKNLN 494
Query: 542 RFAEALHYYKLAIGSRP----------TLASAYLNTGIILMNQGRTEEARRTFLKCSEIP 591
R EA Y +A P +A +LN I L N R E+R E
Sbjct: 495 RTKEAEESYMMAKSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESR------LEEA 548
Query: 592 DENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGE 651
D+ + + + + G+L + +A Y +A++ + R A L+ +
Sbjct: 549 DQLYRQAISMRPDFKQAYISRGELLLKMNKPLKAKEAYLKALE-LDRNNA--DLWYNLAI 605
Query: 652 AYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGR---KSEAEKLFLKAIELDP 708
++ L + EA + +L H A ++ +G + EA K L I +P
Sbjct: 606 VHIELKEPNEALKNFNRALELNPKHKLALFNSAIVMQESGEVKLRPEARKRLLSYINEEP 665
Query: 709 TKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYY 768
N Y + G +++ + EA KKA +L + +FN A + Q + A
Sbjct: 666 LDANGYFNLGMLAMDDKKDNEAEIWMKKAIKLQADFRSALFNLALLYSQTAKELKALPIL 725
Query: 769 DLAARLRPNYPAALMNLGAIL-HLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIME 827
+ R P++ L+ G IL + + A+ + R L++ P +V + NL ++ E
Sbjct: 726 EELLRYYPDHIKGLILKGDILMNQKKDILGAKKCFERILEMDPSNVQGKHNLCVVY-FEE 784
Query: 828 KQGLKTSK 835
K LK +
Sbjct: 785 KDLLKAER 792
>gi|83415184 transmembrane and tetratricopeptide repeat containing 1
[Homo sapiens]
Length = 774
Score = 184 bits (466), Expect = 4e-46
Identities = 147/492 (29%), Positives = 216/492 (43%), Gaps = 71/492 (14%)
Query: 394 VVLSLSLLIIPFVPATNLFFYVGFVIAERVLYIPSMGFCLLITVGARALYVKVQKRFLKS 453
V++ L L+ PF+PA+NLFF VGFV+AERVLY+PSMG+C+L G L + + +
Sbjct: 275 VLVGLLFLVFPFIPASNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKLCTWLNRCGATT 334
Query: 454 LIFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNP--AKAWGNLGNVLKSQSKISE 511
LI +T L++ + KT +N W + E L+RSG++ P AK N N LK Q + E
Sbjct: 335 LI-VSTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKE 393
Query: 512 AESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIIL 571
A YR AL A L NLG L ++ AEA YY+ A+ P A N G +L
Sbjct: 394 AIYHYRTALKLYPRHASALNNLGTLTRDT---AEAKMYYQRALQLHPQHNRALFNLGNLL 450
Query: 572 MNQGRTEEA---------------------------RRTFLKCSEIPDENLK------DP 598
+Q + EEA + F + EI +K D
Sbjct: 451 KSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTGIKNCPDSSDL 510
Query: 599 H-----------------AHKSSVTS-------CLYNLGKLYHEQGHYEEALSVYKEAIQ 634
H AH + NLG+LY G A YK A+Q
Sbjct: 511 HNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSMAEEWYKRALQ 570
Query: 635 KMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKS 694
+ + + +G Y + EA Y E+ + L ++LA+ G+
Sbjct: 571 VAHK----AEILSPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTK 626
Query: 695 EAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVV----FN 750
EAEK+ + + CY ++ +A + KA +L + V+ F
Sbjct: 627 EAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFT 686
Query: 751 AAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKP 810
+ LR+ +L + A + Y +A +L P+ A MN+G I H+ G+ A A Y RALQL P
Sbjct: 687 KGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVP 746
Query: 811 DDVITQSNLRKL 822
D + + NL KL
Sbjct: 747 DSKLLKENLAKL 758
Score = 122 bits (307), Expect = 1e-27
Identities = 95/270 (35%), Positives = 133/270 (49%), Gaps = 29/270 (10%)
Query: 82 LNPWSYHLVNVLLHAAVT-GLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAVAGIVGRA 140
+NP+ +H VN++LH VT L + K + + F+ L+FA HPIHTEAVAGIVGRA
Sbjct: 1 MNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRA 60
Query: 141 DVGASLFFLLSLLCYIKH----CSTRGYSARTWGWFLGSGLCAG-CSMLWKEQGVTVLAV 195
DV A L FLL+ L Y + C + + +FL L G C+ML KE G+TV V
Sbjct: 61 DVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSPFFLLLSLFLGTCAMLVKETGITVFGV 120
Query: 196 SAVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLG-------------AR 242
VYD+F + K + R SSL G +
Sbjct: 121 CLVYDLFSLSNKQDKSSNGALCPRSPQQPGSP------QPSSLPGHPHRENGKQQRFPHK 174
Query: 243 LYWMG---NKPPSFSNSDNPAAD-SDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDA 298
W G PP +S P + + + R LT+ YL N+WLLL P TL +DW + +
Sbjct: 175 GAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRFLTYSYLLAFNVWLLLAPVTLCYDWQVGS 234
Query: 299 VPLLKTVCDWRNLHTVAFYTGLLLLAYYGL 328
+PL++T+ D RNL T+ + LL+ + L
Sbjct: 235 IPLVETIWDMRNLATIFLAVVMALLSLHCL 264
Score = 96.3 bits (238), Expect = 1e-19
Identities = 97/393 (24%), Positives = 168/393 (42%), Gaps = 43/393 (10%)
Query: 441 ALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRN-----GDWQNEEMLYRSGIKVNPA-- 493
A ++K Q R +++ Y TA L ++ +A+ N D +M Y+ ++++P
Sbjct: 382 ANFLKDQGRNKEAIYHYRTA-LKLYPRHASALNNLGTLTRDTAEAKMYYQRALQLHPQHN 440
Query: 494 KAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLA 553
+A NLGN+LKSQ K EA + ++++ Y AD +L LL E RF EA Y+
Sbjct: 441 RALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKEAEEIYQTG 500
Query: 554 IGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEI-PDENLKDPH------------- 599
I + P + + N G+ L++ G E+A + + ++ P ++ +
Sbjct: 501 IKNCPDSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSM 560
Query: 600 -----------AHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNM 648
AHK+ + S LG LY+ G YEEAL +Y+EA P Q + L
Sbjct: 561 AEEWYKRALQVAHKAEILS---PLGALYYNTGRYEEALQIYQEAAALQPSQ---RELRLA 614
Query: 649 MGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDP 708
+ + + + EAE + +T + + + + +A KA++L P
Sbjct: 615 LAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKALDAIDKALQLKP 674
Query: 709 TK----GNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAA 764
+ G L E+ L +A E + A +L+ + N + +A
Sbjct: 675 KDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHIKGKYVSA 734
Query: 765 EKYYDLAARLRPNYPAALMNLGAILHLNGRLQK 797
YY+ A +L P+ NL + L RLQ+
Sbjct: 735 RAYYERALQLVPDSKLLKENLAKLDRLEKRLQE 767
Score = 52.4 bits (124), Expect = 2e-06
Identities = 51/222 (22%), Positives = 82/222 (36%), Gaps = 40/222 (18%)
Query: 610 YNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMES 669
YN +QG +EA+ Y+ A++ PR S N +G + EA+ +Y +
Sbjct: 379 YNYANFLKDQGRNKEAIYHYRTALKLYPRH---ASALNNLGTLTRDTA---EAKMYYQRA 432
Query: 670 LRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIE 729
L+ H A G LL +K EA L +I+ P + Y L E+ R E
Sbjct: 433 LQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQERFKE 492
Query: 730 AAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAIL 789
A E+ Y + P+ N G L
Sbjct: 493 AEEI----------------------------------YQTGIKNCPDSSDLHNNYGVFL 518
Query: 790 HLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGL 831
G +KA A+Y +A++L P + NL +L+ + + +
Sbjct: 519 VDTGLPEKAVAHYQQAIKLSPSHHVAMVNLGRLYRSLGENSM 560
>gi|32307150 O-linked GlcNAc transferase isoform 2 [Homo sapiens]
Length = 1036
Score = 116 bits (291), Expect = 8e-26
Identities = 91/339 (26%), Positives = 152/339 (44%), Gaps = 16/339 (4%)
Query: 475 GDWQNEEMLYRSGIKVNPAK--AWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYN 532
GD + Y S ++ NP +LGN+LK+ ++ EA++ Y A+ + N A N
Sbjct: 127 GDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 186
Query: 533 LGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPD 592
LG + A+H+++ A+ P AY+N G +L + A +L+
Sbjct: 187 LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRAL---- 242
Query: 593 ENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEA 652
+L HA NL +Y+EQG + A+ Y+ AI+ P P + N+ A
Sbjct: 243 -SLSPNHAVVHG------NLACVYYEQGLIDLAIDTYRRAIELQPH--FPDAYCNL-ANA 292
Query: 653 YMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGN 712
+ EAE Y +LR H + + G EA +L+ KA+E+ P
Sbjct: 293 LKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAA 352
Query: 713 CYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAA 772
+ + L ++ +L EA K+A + T D N + L++ + A + Y A
Sbjct: 353 AHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAI 412
Query: 773 RLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPD 811
++ P + A NL +I +G + +A A+Y AL+LKPD
Sbjct: 413 QINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 451
Score = 107 bits (266), Expect = 6e-23
Identities = 90/334 (26%), Positives = 142/334 (42%), Gaps = 16/334 (4%)
Query: 488 IKVNP--AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAE 545
IK NP A+A+ NLGNV K + ++ EA YR+AL + + D NL L
Sbjct: 72 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEG 131
Query: 546 ALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSV 605
A+ Y A+ P L + G +L GR EEA+ +LK E + +
Sbjct: 132 AVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIET-----------QPNF 180
Query: 606 TSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHW 665
NLG +++ QG A+ +++A+ P Y +G A
Sbjct: 181 AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFL---DAYINLGNVLKEARIFDRAVAA 237
Query: 666 YMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEA 725
Y+ +L +H H + G A + +AIEL P + Y + L E+
Sbjct: 238 YLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKG 297
Query: 726 RLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNL 785
+ EA + A L T D + N A++ R+ E A + Y A + P + AA NL
Sbjct: 298 SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNL 357
Query: 786 GAILHLNGRLQKAEANYLRALQLKPDDVITQSNL 819
++L G+LQ+A +Y A+++ P SN+
Sbjct: 358 ASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 391
Score = 85.5 bits (210), Expect = 2e-16
Identities = 90/339 (26%), Positives = 142/339 (41%), Gaps = 28/339 (8%)
Query: 499 LGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENS------RFAEALHYYKL 552
L + + + + E+A R+ + D N G+LL +S R + H+ L
Sbjct: 14 LAELAHREYQAGDFEAAERHCMQLWRQEPD---NTGVLLLLSSIHFQCRRLDRSAHFSTL 70
Query: 553 AIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNL 612
AI P LA AY N G + +G+ +EA + + K NL
Sbjct: 71 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL-----------KPDFIDGYINL 119
Query: 613 GKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRS 672
G E A+ Y A+Q P + +S +G L +L EA+ Y++++ +
Sbjct: 120 AAALVAAGDMEGAVQAYVSALQYNPDLYCVRS---DLGNLLKALGRLEEAKACYLKAIET 176
Query: 673 KTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAE 732
+ + A G + G A F KA+ LDP + Y++ G +L+EAR+ + A
Sbjct: 177 QPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGN-VLKEARIFDRAV 235
Query: 733 MAK-KAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHL 791
A +A L V N A + + L + A Y A L+P++P A NL L
Sbjct: 236 AAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKE 295
Query: 792 NGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQG 830
G + +AE Y AL+L P +L L NI +QG
Sbjct: 296 KGSVAEAEDCYNTALRLCPTHA---DSLNNLANIKREQG 331
Score = 73.6 bits (179), Expect = 7e-13
Identities = 71/256 (27%), Positives = 101/256 (39%), Gaps = 14/256 (5%)
Query: 491 NPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYY 550
N A GNL V Q I A YR A+ + + D NL L+E AEA Y
Sbjct: 247 NHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCY 306
Query: 551 KLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLY 610
A+ PT A + N I QG EEA R + K E+ E AH
Sbjct: 307 NTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAA---AHS-------- 355
Query: 611 NLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESL 670
NL + +QG +EAL YKEAI+ P FA Y+ MG + + A Y ++
Sbjct: 356 NLASVLQQQGKLQEALMHYKEAIRISPT-FA--DAYSNMGNTLKEMQDVQGALQCYTRAI 412
Query: 671 RSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEA 730
+ AH + +G EA + A++L P + Y + L +
Sbjct: 413 QINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDY 472
Query: 731 AEMAKKAAELDSTEFD 746
E KK + + + +
Sbjct: 473 DERMKKLVSIVADQLE 488
>gi|32307148 O-linked GlcNAc transferase isoform 1 [Homo sapiens]
Length = 1046
Score = 116 bits (291), Expect = 8e-26
Identities = 91/339 (26%), Positives = 152/339 (44%), Gaps = 16/339 (4%)
Query: 475 GDWQNEEMLYRSGIKVNPAK--AWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYN 532
GD + Y S ++ NP +LGN+LK+ ++ EA++ Y A+ + N A N
Sbjct: 137 GDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIETQPNFAVAWSN 196
Query: 533 LGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPD 592
LG + A+H+++ A+ P AY+N G +L + A +L+
Sbjct: 197 LGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGNVLKEARIFDRAVAAYLRAL---- 252
Query: 593 ENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEA 652
+L HA NL +Y+EQG + A+ Y+ AI+ P P + N+ A
Sbjct: 253 -SLSPNHAVVHG------NLACVYYEQGLIDLAIDTYRRAIELQPH--FPDAYCNL-ANA 302
Query: 653 YMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGN 712
+ EAE Y +LR H + + G EA +L+ KA+E+ P
Sbjct: 303 LKEKGSVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAA 362
Query: 713 CYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAA 772
+ + L ++ +L EA K+A + T D N + L++ + A + Y A
Sbjct: 363 AHSNLASVLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAI 422
Query: 773 RLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPD 811
++ P + A NL +I +G + +A A+Y AL+LKPD
Sbjct: 423 QINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPD 461
Score = 107 bits (266), Expect = 6e-23
Identities = 90/334 (26%), Positives = 142/334 (42%), Gaps = 16/334 (4%)
Query: 488 IKVNP--AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAE 545
IK NP A+A+ NLGNV K + ++ EA YR+AL + + D NL L
Sbjct: 82 IKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLKPDFIDGYINLAAALVAAGDMEG 141
Query: 546 ALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSV 605
A+ Y A+ P L + G +L GR EEA+ +LK E + +
Sbjct: 142 AVQAYVSALQYNPDLYCVRSDLGNLLKALGRLEEAKACYLKAIET-----------QPNF 190
Query: 606 TSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHW 665
NLG +++ QG A+ +++A+ P Y +G A
Sbjct: 191 AVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFL---DAYINLGNVLKEARIFDRAVAA 247
Query: 666 YMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEA 725
Y+ +L +H H + G A + +AIEL P + Y + L E+
Sbjct: 248 YLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKG 307
Query: 726 RLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNL 785
+ EA + A L T D + N A++ R+ E A + Y A + P + AA NL
Sbjct: 308 SVAEAEDCYNTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNL 367
Query: 786 GAILHLNGRLQKAEANYLRALQLKPDDVITQSNL 819
++L G+LQ+A +Y A+++ P SN+
Sbjct: 368 ASVLQQQGKLQEALMHYKEAIRISPTFADAYSNM 401
Score = 85.5 bits (210), Expect = 2e-16
Identities = 90/339 (26%), Positives = 142/339 (41%), Gaps = 28/339 (8%)
Query: 499 LGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENS------RFAEALHYYKL 552
L + + + + E+A R+ + D N G+LL +S R + H+ L
Sbjct: 24 LAELAHREYQAGDFEAAERHCMQLWRQEPD---NTGVLLLLSSIHFQCRRLDRSAHFSTL 80
Query: 553 AIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNL 612
AI P LA AY N G + +G+ +EA + + K NL
Sbjct: 81 AIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRL-----------KPDFIDGYINL 129
Query: 613 GKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRS 672
G E A+ Y A+Q P + +S +G L +L EA+ Y++++ +
Sbjct: 130 AAALVAAGDMEGAVQAYVSALQYNPDLYCVRS---DLGNLLKALGRLEEAKACYLKAIET 186
Query: 673 KTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAE 732
+ + A G + G A F KA+ LDP + Y++ G +L+EAR+ + A
Sbjct: 187 QPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVTLDPNFLDAYINLGN-VLKEARIFDRAV 245
Query: 733 MAK-KAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHL 791
A +A L V N A + + L + A Y A L+P++P A NL L
Sbjct: 246 AAYLRALSLSPNHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKE 305
Query: 792 NGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQG 830
G + +AE Y AL+L P +L L NI +QG
Sbjct: 306 KGSVAEAEDCYNTALRLCPTHA---DSLNNLANIKREQG 341
Score = 73.6 bits (179), Expect = 7e-13
Identities = 71/256 (27%), Positives = 101/256 (39%), Gaps = 14/256 (5%)
Query: 491 NPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYY 550
N A GNL V Q I A YR A+ + + D NL L+E AEA Y
Sbjct: 257 NHAVVHGNLACVYYEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCY 316
Query: 551 KLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLY 610
A+ PT A + N I QG EEA R + K E+ E AH
Sbjct: 317 NTALRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAA---AHS-------- 365
Query: 611 NLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESL 670
NL + +QG +EAL YKEAI+ P FA Y+ MG + + A Y ++
Sbjct: 366 NLASVLQQQGKLQEALMHYKEAIRISPT-FA--DAYSNMGNTLKEMQDVQGALQCYTRAI 422
Query: 671 RSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEA 730
+ AH + +G EA + A++L P + Y + L +
Sbjct: 423 QINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQIVCDWTDY 482
Query: 731 AEMAKKAAELDSTEFD 746
E KK + + + +
Sbjct: 483 DERMKKLVSIVADQLE 498
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 58.9 bits (141), Expect = 2e-08
Identities = 89/457 (19%), Positives = 162/457 (35%), Gaps = 67/457 (14%)
Query: 443 YVKVQKRFLKSLIFYATATLIVFYGL-KTAIRNGDWQNEEMLYRSGIKVNP-----AKAW 496
Y + + + ++ F +++ ++ F+GL + I GD +N + +K P K
Sbjct: 322 YDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRGDKENASQCFEKVLKAYPNNYETMKIL 381
Query: 497 GNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGS 556
G+L + Q K A+ + + + L +L++ AL Y A
Sbjct: 382 GSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTD-IQGALSAYGTATRI 440
Query: 557 RPTLASAYL------NTGIILMNQGRTEEARRTFL-KCSEIPDENLKDPHAHKSSVTSCL 609
A + N G + G EA++ FL E D H + + +
Sbjct: 441 LQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTS 500
Query: 610 YNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMES 669
YNL +LY + EA +YK +++ P Y +G EA W+ E+
Sbjct: 501 YNLARLYEAMCEFHEAEKLYKNILREHPNYV---DCYLRLGAMARDKGNFYEASDWFKEA 557
Query: 670 LRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCY------------MH- 716
L+ DH A G L +K F + ++ T+ + Y +H
Sbjct: 558 LQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQTLHQ 617
Query: 717 ------------------YGQFLLEEARLI-----------------EAAEMAKKAAELD 741
Y Q L +A+ + EA ++ + E
Sbjct: 618 PTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREAT 677
Query: 742 STEFDVVFNAAHMLRQASLNEAAEKYYDLAAR--LRPNYPAALMNLGAILHLNGRLQKAE 799
+ DV N AH+ + +A + Y+ R + ++ L L G+LQ+ +
Sbjct: 678 ADISDVWLNLAHIYVEQKQYISAVQMYENCLRKFYKHQNTEVVLYLARALFKCGKLQECK 737
Query: 800 ANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSKT 836
L+A + P D + N+ + + LK K+
Sbjct: 738 QTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKS 774
Score = 45.1 bits (105), Expect = 3e-04
Identities = 80/392 (20%), Positives = 142/392 (36%), Gaps = 62/392 (15%)
Query: 476 DWQNEEMLYRSGIKVNP---AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYN 532
D++ Y+ ++ NP A+ +G+ +K+ +A A+ AL S L
Sbjct: 178 DYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVG 237
Query: 533 LGLLLQENSRFAEALH---------------------------YYKLAIGSRPTLA-SAY 564
L +L + N++ A+++ ++K LA A+
Sbjct: 238 LAVL-ELNNKEADSIKNGVQLLSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAF 296
Query: 565 LNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAH----KSSVTSCLYNLGKLYHEQG 620
NT + M + R+F E D+ + + SS + LG++Y +G
Sbjct: 297 HNTEVEAMQAESCYQLARSF-HVQEDYDQAFQYYYQATQFASSSFVLPFFGLGQMYIYRG 355
Query: 621 HYEEALSVYKEAIQKMPRQFAPQ----SLYNMMGEAYMR------LSKLPE-----AEHW 665
E A +++ ++ P + SLY + R L K+ E E W
Sbjct: 356 DKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAW 415
Query: 666 Y-MESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEE 724
+ + +TD A YG + K +A+ E+ G + G +
Sbjct: 416 IELAQILEQTDIQGALSAYGTATRILQEKVQADV----PPEILNNVGALHFRLGNLGEAK 471
Query: 725 ARLIEAAEMAKKAAELDSTEFDVV-----FNAAHMLRQASLNEAAEKYYDLAARLRPNYP 779
+ + + AK AE D ++ + +N A + AEK Y R PNY
Sbjct: 472 KYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREHPNYV 531
Query: 780 AALMNLGAILHLNGRLQKAEANYLRALQLKPD 811
+ LGA+ G +A + ALQ+ D
Sbjct: 532 DCYLRLGAMARDKGNFYEASDWFKEALQINQD 563
>gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 55.1 bits (131), Expect = 3e-07
Identities = 73/289 (25%), Positives = 118/289 (40%), Gaps = 15/289 (5%)
Query: 527 ADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRT-EEARRTFL 585
AD LYNLGL E YKLAI T S N+ I N+ + R +
Sbjct: 1195 ADCLYNLGLCYMEEGNLQMT---YKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQM 1251
Query: 586 KCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSL 645
++ L D A ++ + N G +Y E G Y AL +K+A SL
Sbjct: 1252 ALTDYGIVLLLD--ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN---GSL 1306
Query: 646 YNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGR---KSEAEKLFLK 702
+ + R+++ EA +++ +L+ + A++ G G +A+K FLK
Sbjct: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366
Query: 703 AIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNE 762
A+ ++P + +G L + + +A A + D + A + Q N
Sbjct: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNF 1426
Query: 763 AAEKYYDLAARLRPNYPAA-LMNLGAILHLNGRLQKAEANYLRALQLKP 810
AA + D+ A ++ + A L N G I G Q A +Y A+ L P
Sbjct: 1427 AAMQ--DINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473
Score = 55.1 bits (131), Expect = 3e-07
Identities = 64/282 (22%), Positives = 109/282 (38%), Gaps = 28/282 (9%)
Query: 541 SRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGR---TEEARRTFLKCSEIPDENLKD 597
+ F EA++++ A+ P AY+ G M G T++A++ FLK I +K
Sbjct: 1318 NEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIK- 1376
Query: 598 PHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQS----LYNMMGEAY 653
+ S YNL QG +++A + + AI P+ + + MG +
Sbjct: 1377 ------ARISFGYNL----QAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNF 1426
Query: 654 MRLSKLPEAEHWYMESLRSKTDHIPAHLTY-GKLLALTGRKSEAEKLFLKAIELDPTKGN 712
+ + A K LT G + G K A K + AI L+P
Sbjct: 1427 AAMQDINAA---------MKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSL 1477
Query: 713 CYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAA 772
Y + G + +A++ KA + D V+ N A E A++ +
Sbjct: 1478 AYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVI 1537
Query: 773 RLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVI 814
P + A N + + + AE + +AL LKP+D +
Sbjct: 1538 ESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDAL 1579
Score = 42.7 bits (99), Expect = 0.001
Identities = 61/262 (23%), Positives = 103/262 (39%), Gaps = 28/262 (10%)
Query: 570 ILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGH----YEEA 625
+ M RT+EA K + + K P A S CLYNLG Y E+G+ Y+ A
Sbjct: 1160 VQMKAKRTKEAVEVLKKALDASSHSDKGPDATTISA-DCLYNLGLCYMEEGNLQMTYKLA 1218
Query: 626 LSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESL---RSKTDHIPAHLT 682
++ AI + + YN Y ++ +L A Y L ++T + L
Sbjct: 1219 ITDLTTAISMDKNSYI--AFYN-RALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275
Query: 683 YGKLLALTGRKSEAEKLFLKAIELDPTKGN-------CYMHYGQFLLEEARLIEAAEMAK 735
G + G+ A + F +A + T G+ C+ +F EA
Sbjct: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF-------EEAVNFFT 1328
Query: 736 KAAELDSTEFDVVFNAAHMLRQASLNEA---AEKYYDLAARLRPNYPAALMNLGAILHLN 792
A +++ D + + +EA A+K + A + P Y A ++ G L
Sbjct: 1329 WALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQ 1388
Query: 793 GRLQKAEANYLRALQLKPDDVI 814
G+ QKA ++ A+ P + +
Sbjct: 1389 GKFQKAWNHFTIAIDTDPKNYL 1410
Score = 33.9 bits (76), Expect = 0.64
Identities = 61/267 (22%), Positives = 100/267 (37%), Gaps = 21/267 (7%)
Query: 445 KVQKRFLKSLIF---YATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGN 501
+ QK FLK+L Y A + Y L+ G +Q + I +P G
Sbjct: 1359 QAQKDFLKALHINPAYIKARISFGYNLQA---QGKFQKAWNHFTIAIDTDPKNYLAYEGR 1415
Query: 502 -VLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTL 560
V+ Q + A NA S A+ L N G++ + A+ Y+ AI P
Sbjct: 1416 AVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKY 1475
Query: 561 ASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQG 620
+ AY N G I + + +A F K + EN + ++T+ +
Sbjct: 1476 SLAYFNAGNIYFHHRQFSQASDYFSKALKFDPEN--EYVLMNRAITNTILK--------- 1524
Query: 621 HYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAH 680
YEEA + I+ P A +Y Y L + AE ++L K + +
Sbjct: 1525 KYEEAKEDFANVIESCPFWAA---VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581
Query: 681 LTYGKLLALTGRKSEAEKLFLKAIELD 707
K+ G EA + +A++L+
Sbjct: 1582 NFRAKVRGKIGLIEEAMADYNQALDLE 1608
>gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo
sapiens]
Length = 1614
Score = 55.1 bits (131), Expect = 3e-07
Identities = 73/289 (25%), Positives = 118/289 (40%), Gaps = 15/289 (5%)
Query: 527 ADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRT-EEARRTFL 585
AD LYNLGL E YKLAI T S N+ I N+ + R +
Sbjct: 1195 ADCLYNLGLCYMEEGNLQMT---YKLAITDLTTAISMDKNSYIAFYNRALCYTKIRELQM 1251
Query: 586 KCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSL 645
++ L D A ++ + N G +Y E G Y AL +K+A SL
Sbjct: 1252 ALTDYGIVLLLD--ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN---GSL 1306
Query: 646 YNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGR---KSEAEKLFLK 702
+ + R+++ EA +++ +L+ + A++ G G +A+K FLK
Sbjct: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366
Query: 703 AIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNE 762
A+ ++P + +G L + + +A A + D + A + Q N
Sbjct: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNF 1426
Query: 763 AAEKYYDLAARLRPNYPAA-LMNLGAILHLNGRLQKAEANYLRALQLKP 810
AA + D+ A ++ + A L N G I G Q A +Y A+ L P
Sbjct: 1427 AAMQ--DINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473
Score = 55.1 bits (131), Expect = 3e-07
Identities = 64/282 (22%), Positives = 109/282 (38%), Gaps = 28/282 (9%)
Query: 541 SRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGR---TEEARRTFLKCSEIPDENLKD 597
+ F EA++++ A+ P AY+ G M G T++A++ FLK I +K
Sbjct: 1318 NEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIK- 1376
Query: 598 PHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQS----LYNMMGEAY 653
+ S YNL QG +++A + + AI P+ + + MG +
Sbjct: 1377 ------ARISFGYNL----QAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNF 1426
Query: 654 MRLSKLPEAEHWYMESLRSKTDHIPAHLTY-GKLLALTGRKSEAEKLFLKAIELDPTKGN 712
+ + A K LT G + G K A K + AI L+P
Sbjct: 1427 AAMQDINAA---------MKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSL 1477
Query: 713 CYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAA 772
Y + G + +A++ KA + D V+ N A E A++ +
Sbjct: 1478 AYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVI 1537
Query: 773 RLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVI 814
P + A N + + + AE + +AL LKP+D +
Sbjct: 1538 ESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDAL 1579
Score = 42.0 bits (97), Expect = 0.002
Identities = 61/262 (23%), Positives = 103/262 (39%), Gaps = 28/262 (10%)
Query: 570 ILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGH----YEEA 625
+ M RT+EA K + + K P A S CLYNLG Y E+G+ Y+ A
Sbjct: 1160 VQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISA-DCLYNLGLCYMEEGNLQMTYKLA 1218
Query: 626 LSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESL---RSKTDHIPAHLT 682
++ AI + + YN Y ++ +L A Y L ++T + L
Sbjct: 1219 ITDLTTAISMDKNSYI--AFYN-RALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275
Query: 683 YGKLLALTGRKSEAEKLFLKAIELDPTKGN-------CYMHYGQFLLEEARLIEAAEMAK 735
G + G+ A + F +A + T G+ C+ +F EA
Sbjct: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF-------EEAVNFFT 1328
Query: 736 KAAELDSTEFDVVFNAAHMLRQASLNEA---AEKYYDLAARLRPNYPAALMNLGAILHLN 792
A +++ D + + +EA A+K + A + P Y A ++ G L
Sbjct: 1329 WALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQ 1388
Query: 793 GRLQKAEANYLRALQLKPDDVI 814
G+ QKA ++ A+ P + +
Sbjct: 1389 GKFQKAWNHFTIAIDTDPKNYL 1410
Score = 33.9 bits (76), Expect = 0.64
Identities = 61/267 (22%), Positives = 100/267 (37%), Gaps = 21/267 (7%)
Query: 445 KVQKRFLKSLIF---YATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGN 501
+ QK FLK+L Y A + Y L+ G +Q + I +P G
Sbjct: 1359 QAQKDFLKALHINPAYIKARISFGYNLQA---QGKFQKAWNHFTIAIDTDPKNYLAYEGR 1415
Query: 502 -VLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTL 560
V+ Q + A NA S A+ L N G++ + A+ Y+ AI P
Sbjct: 1416 AVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKY 1475
Query: 561 ASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQG 620
+ AY N G I + + +A F K + EN + ++T+ +
Sbjct: 1476 SLAYFNAGNIYFHHRQFSQASDYFSKALKFDPEN--EYVLMNRAITNTILK--------- 1524
Query: 621 HYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAH 680
YEEA + I+ P A +Y Y L + AE ++L K + +
Sbjct: 1525 KYEEAKEDFANVIESCPFWAA---VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581
Query: 681 LTYGKLLALTGRKSEAEKLFLKAIELD 707
K+ G EA + +A++L+
Sbjct: 1582 NFRAKVRGKIGLIEEAMADYNQALDLE 1608
>gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo
sapiens]
Length = 1614
Score = 55.1 bits (131), Expect = 3e-07
Identities = 64/282 (22%), Positives = 109/282 (38%), Gaps = 28/282 (9%)
Query: 541 SRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGR---TEEARRTFLKCSEIPDENLKD 597
+ F EA++++ A+ P AY+ G M G T++A++ FLK I +K
Sbjct: 1318 NEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIK- 1376
Query: 598 PHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQS----LYNMMGEAY 653
+ S YNL QG +++A + + AI P+ + + MG +
Sbjct: 1377 ------ARISFGYNL----QAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNF 1426
Query: 654 MRLSKLPEAEHWYMESLRSKTDHIPAHLTY-GKLLALTGRKSEAEKLFLKAIELDPTKGN 712
+ + A K LT G + G K A K + AI L+P
Sbjct: 1427 AAMQDINAA---------MKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKYSL 1477
Query: 713 CYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAA 772
Y + G + +A++ KA + D V+ N A E A++ +
Sbjct: 1478 AYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRAITNTILKKYEEAKEDFANVI 1537
Query: 773 RLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDDVI 814
P + A N + + + AE + +AL LKP+D +
Sbjct: 1538 ESCPFWAAVYFNRAHFYYCLKQYELAEEDLNKALSLKPNDAL 1579
Score = 53.1 bits (126), Expect = 1e-06
Identities = 72/289 (24%), Positives = 117/289 (40%), Gaps = 15/289 (5%)
Query: 527 ADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRT-EEARRTFL 585
AD LYNLGL E YKLAI T S N+ N+ + R +
Sbjct: 1195 ADCLYNLGLCYMEEGNLQMT---YKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQM 1251
Query: 586 KCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSL 645
++ L D A ++ + N G +Y E G Y AL +K+A SL
Sbjct: 1252 ALTDYGIVLLLD--ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTN---GSL 1306
Query: 646 YNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGR---KSEAEKLFLK 702
+ + R+++ EA +++ +L+ + A++ G G +A+K FLK
Sbjct: 1307 CHATAMCHHRINEFEEAVNFFTWALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLK 1366
Query: 703 AIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNE 762
A+ ++P + +G L + + +A A + D + A + Q N
Sbjct: 1367 ALHINPAYIKARISFGYNLQAQGKFQKAWNHFTIAIDTDPKNYLAYEGRAVVCLQMGNNF 1426
Query: 763 AAEKYYDLAARLRPNYPAA-LMNLGAILHLNGRLQKAEANYLRALQLKP 810
AA + D+ A ++ + A L N G I G Q A +Y A+ L P
Sbjct: 1427 AAMQ--DINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNP 1473
Score = 42.4 bits (98), Expect = 0.002
Identities = 61/262 (23%), Positives = 103/262 (39%), Gaps = 28/262 (10%)
Query: 570 ILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGH----YEEA 625
+ M RT+EA K + + K P A S CLYNLG Y E+G+ Y+ A
Sbjct: 1160 VQMKAKRTKEAVEVLKKALDAISHSDKGPDATAISA-DCLYNLGLCYMEEGNLQMTYKLA 1218
Query: 626 LSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESL---RSKTDHIPAHLT 682
++ AI + + YN Y ++ +L A Y L ++T + L
Sbjct: 1219 ITDLTTAISMDKNSYT--AFYN-RALCYTKIRELQMALTDYGIVLLLDATETVKLNTFLN 1275
Query: 683 YGKLLALTGRKSEAEKLFLKAIELDPTKGN-------CYMHYGQFLLEEARLIEAAEMAK 735
G + G+ A + F +A + T G+ C+ +F EA
Sbjct: 1276 RGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEF-------EEAVNFFT 1328
Query: 736 KAAELDSTEFDVVFNAAHMLRQASLNEA---AEKYYDLAARLRPNYPAALMNLGAILHLN 792
A +++ D + + +EA A+K + A + P Y A ++ G L
Sbjct: 1329 WALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNLQAQ 1388
Query: 793 GRLQKAEANYLRALQLKPDDVI 814
G+ QKA ++ A+ P + +
Sbjct: 1389 GKFQKAWNHFTIAIDTDPKNYL 1410
Score = 33.9 bits (76), Expect = 0.64
Identities = 61/267 (22%), Positives = 100/267 (37%), Gaps = 21/267 (7%)
Query: 445 KVQKRFLKSLIF---YATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVNPAKAWGNLGN 501
+ QK FLK+L Y A + Y L+ G +Q + I +P G
Sbjct: 1359 QAQKDFLKALHINPAYIKARISFGYNLQA---QGKFQKAWNHFTIAIDTDPKNYLAYEGR 1415
Query: 502 -VLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTL 560
V+ Q + A NA S A+ L N G++ + A+ Y+ AI P
Sbjct: 1416 AVVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEFMGHKQNAMKDYQDAITLNPKY 1475
Query: 561 ASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQG 620
+ AY N G I + + +A F K + EN + ++T+ +
Sbjct: 1476 SLAYFNAGNIYFHHRQFSQASDYFSKALKFDPEN--EYVLMNRAITNTILK--------- 1524
Query: 621 HYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAH 680
YEEA + I+ P A +Y Y L + AE ++L K + +
Sbjct: 1525 KYEEAKEDFANVIESCPFWAA---VYFNRAHFYYCLKQYELAEEDLNKALSLKPNDALVY 1581
Query: 681 LTYGKLLALTGRKSEAEKLFLKAIELD 707
K+ G EA + +A++L+
Sbjct: 1582 NFRAKVRGKIGLIEEAMADYNQALDLE 1608
>gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo
sapiens]
Length = 833
Score = 53.1 bits (126), Expect = 1e-06
Identities = 71/320 (22%), Positives = 121/320 (37%), Gaps = 47/320 (14%)
Query: 529 MLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCS 588
+L+NL N +AEAL+ Y++ + ++ + N GI+ MN G +R + K
Sbjct: 208 VLFNLASQYSVNEMYAEALNTYQVIVKNK-----MFSNAGILKMNMGNIYLKQRNYSKAI 262
Query: 589 EIPDENLKD-PHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLY- 646
+ L P +K + N+G + + G Y +A++ Y+ + P A +L
Sbjct: 263 KFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTI 322
Query: 647 --------NMMGEAYMRLSKLP------------EAEHWYMESLRSKTDHIPAHLTYGKL 686
M +A+ +L +P + H + + K DH+ K
Sbjct: 323 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 382
Query: 687 LALTGRKSEAEKLFLKAIE----------LDPTKGNCYMHYGQFL--------LEEARLI 728
+A + A KL IE ++ K + Y+ L L +
Sbjct: 383 MAEKYIMTSA-KLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQKDYN 441
Query: 729 EAAEMAKKAAELDS-TEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGA 787
+A E+ K + DS + N + + A Y D+A PAAL N G
Sbjct: 442 QAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGN 501
Query: 788 ILHLNGRLQKAEANYLRALQ 807
+ NG +KA Y AL+
Sbjct: 502 TVFANGDYEKAAEFYKEALR 521
Score = 44.7 bits (104), Expect = 4e-04
Identities = 56/254 (22%), Positives = 96/254 (37%), Gaps = 18/254 (7%)
Query: 489 KVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALH 548
+ NPA A N GN + + +A Y+ AL S+ + LYN+GL ++ +R EAL
Sbjct: 490 RYNPA-ALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALD 548
Query: 549 -YYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTS 607
+ KL R + Y I + + ++ S IP DP
Sbjct: 549 CFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP----TDPQV------- 597
Query: 608 CLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYM 667
L LG+LY +G +A Y E+ + P + +G Y+ +A ++
Sbjct: 598 -LSKLGELYDREGDKSQAFQYYYESYRYFPCNI---EVIEWLGAYYIDTQFWEKAIQYFE 653
Query: 668 ESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARL 727
+ + + L +G +A + P C + + L + L
Sbjct: 654 RASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVEC-LRFLVRLCTDLGL 712
Query: 728 IEAAEMAKKAAELD 741
+A E A+K L+
Sbjct: 713 KDAQEYARKLKRLE 726
Score = 43.9 bits (102), Expect = 6e-04
Identities = 47/229 (20%), Positives = 91/229 (39%), Gaps = 6/229 (2%)
Query: 607 SCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWY 666
+ L N G G YE+A YKEA++ ++LYN+ G Y +L++L EA +
Sbjct: 494 AALTNKGNTVFANGDYEKAAEFYKEALRN--DSSCTEALYNI-GLTYEKLNRLDEALDCF 550
Query: 667 MESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEAR 726
++ + + L S+A + ++ + + PT G+ E
Sbjct: 551 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 610
Query: 727 LIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLG 786
+A + ++ +V+ E A +Y++ A+ ++P + +
Sbjct: 611 KSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVA 670
Query: 787 AILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSK 835
+ +G QKA Y + P++V LR L + GLK ++
Sbjct: 671 SCFRRSGNYQKALDTYKDTHRKFPENV---ECLRFLVRLCTDLGLKDAQ 716
>gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo
sapiens]
Length = 824
Score = 53.1 bits (126), Expect = 1e-06
Identities = 71/320 (22%), Positives = 121/320 (37%), Gaps = 47/320 (14%)
Query: 529 MLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCS 588
+L+NL N +AEAL+ Y++ + ++ + N GI+ MN G +R + K
Sbjct: 199 VLFNLASQYSVNEMYAEALNTYQVIVKNK-----MFSNAGILKMNMGNIYLKQRNYSKAI 253
Query: 589 EIPDENLKD-PHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLY- 646
+ L P +K + N+G + + G Y +A++ Y+ + P A +L
Sbjct: 254 KFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTI 313
Query: 647 --------NMMGEAYMRLSKLP------------EAEHWYMESLRSKTDHIPAHLTYGKL 686
M +A+ +L +P + H + + K DH+ K
Sbjct: 314 CYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKA 373
Query: 687 LALTGRKSEAEKLFLKAIE----------LDPTKGNCYMHYGQFL--------LEEARLI 728
+A + A KL IE ++ K + Y+ L L +
Sbjct: 374 MAEKYIMTSA-KLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQKDYN 432
Query: 729 EAAEMAKKAAELDS-TEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGA 787
+A E+ K + DS + N + + A Y D+A PAAL N G
Sbjct: 433 QAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGN 492
Query: 788 ILHLNGRLQKAEANYLRALQ 807
+ NG +KA Y AL+
Sbjct: 493 TVFANGDYEKAAEFYKEALR 512
Score = 44.7 bits (104), Expect = 4e-04
Identities = 56/254 (22%), Positives = 96/254 (37%), Gaps = 18/254 (7%)
Query: 489 KVNPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALH 548
+ NPA A N GN + + +A Y+ AL S+ + LYN+GL ++ +R EAL
Sbjct: 481 RYNPA-ALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALD 539
Query: 549 -YYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTS 607
+ KL R + Y I + + ++ S IP DP
Sbjct: 540 CFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIP----TDPQV------- 588
Query: 608 CLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYM 667
L LG+LY +G +A Y E+ + P + +G Y+ +A ++
Sbjct: 589 -LSKLGELYDREGDKSQAFQYYYESYRYFPCNI---EVIEWLGAYYIDTQFWEKAIQYFE 644
Query: 668 ESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARL 727
+ + + L +G +A + P C + + L + L
Sbjct: 645 RASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVEC-LRFLVRLCTDLGL 703
Query: 728 IEAAEMAKKAAELD 741
+A E A+K L+
Sbjct: 704 KDAQEYARKLKRLE 717
Score = 43.9 bits (102), Expect = 6e-04
Identities = 47/229 (20%), Positives = 91/229 (39%), Gaps = 6/229 (2%)
Query: 607 SCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWY 666
+ L N G G YE+A YKEA++ ++LYN+ G Y +L++L EA +
Sbjct: 485 AALTNKGNTVFANGDYEKAAEFYKEALRN--DSSCTEALYNI-GLTYEKLNRLDEALDCF 541
Query: 667 MESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEAR 726
++ + + L S+A + ++ + + PT G+ E
Sbjct: 542 LKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGD 601
Query: 727 LIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLG 786
+A + ++ +V+ E A +Y++ A+ ++P + +
Sbjct: 602 KSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVA 661
Query: 787 AILHLNGRLQKAEANYLRALQLKPDDVITQSNLRKLWNIMEKQGLKTSK 835
+ +G QKA Y + P++V LR L + GLK ++
Sbjct: 662 SCFRRSGNYQKALDTYKDTHRKFPENV---ECLRFLVRLCTDLGLKDAQ 707
>gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens]
Length = 519
Score = 52.0 bits (123), Expect = 2e-06
Identities = 38/141 (26%), Positives = 60/141 (42%), Gaps = 11/141 (7%)
Query: 496 WGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIG 555
W N+G + K A S + A Y +LYNLGL+ ++A A H+ AI
Sbjct: 273 WNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAIN 332
Query: 556 SRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKL 615
+P + Y+ + L N E A+R + + H K + L N L
Sbjct: 333 FQPKMGELYMLLAVALTNLEDIENAKRAYAEA----------VHLDKCNPLVNL-NYAVL 381
Query: 616 YHEQGHYEEALSVYKEAIQKM 636
+ QG + AL+ Y+E +K+
Sbjct: 382 LYNQGEKKNALAQYQEMEKKV 402
Score = 48.1 bits (113), Expect = 3e-05
Identities = 56/263 (21%), Positives = 100/263 (38%), Gaps = 25/263 (9%)
Query: 569 IILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSV 628
+I +G +E+ F C+ + ++ + V L+ LGK ++ A+ V
Sbjct: 75 LIFRLEGNIQESLELFQTCAVLSPQSADN----LKQVARSLFLLGK-------HKAAIEV 123
Query: 629 YKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLA 688
Y EA + + + + + +G Y+ L + +A+ +L H ++ GK+
Sbjct: 124 YNEAAKLNQKDW---EISHNLGVCYIYLKQFNKAQDQLHNALNLNR-HDLTYIMLGKIHL 179
Query: 689 LTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVV 748
L G +A +++ KA+E P G L+ +A E A D T + +
Sbjct: 180 LEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAI 239
Query: 749 FNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQL 808
A M++ + A Y + A P P N+G + A + RA L
Sbjct: 240 LAAGSMMQTHGDFDVALTKYRVVACAVPESPPLWNNIGMCFFGKKKYVAAISCLKRANYL 299
Query: 809 KPDDVITQSNLRKLWNIMEKQGL 831
P D W I+ GL
Sbjct: 300 APFD----------WKILYNLGL 312
Score = 42.0 bits (97), Expect = 0.002
Identities = 55/258 (21%), Positives = 100/258 (38%), Gaps = 29/258 (11%)
Query: 499 LGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRP 558
LG + + + +A Y+ A+ + ++L LGLL + + +A + A+ P
Sbjct: 174 LGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKAFEHLGNALTYDP 233
Query: 559 TLASAYLNTGIILMNQGRTEEARRTF--LKCSEIPDE-----NLKDPHAHKS---SVTSC 608
T A L G ++ G + A + + C+ +P+ N+ K + SC
Sbjct: 234 TNYKAILAAGSMMQTHGDFDVALTKYRVVACA-VPESPPLWNNIGMCFFGKKKYVAAISC 292
Query: 609 L--------------YNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYM 654
L YNLG ++ Y A AI P+ LY ++ A
Sbjct: 293 LKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKM---GELYMLLAVALT 349
Query: 655 RLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLK-AIELDPTKGNC 713
L + A+ Y E++ + +L Y LL G K A + + ++ K N
Sbjct: 350 NLEDIENAKRAYAEAVHLDKCNPLVNLNYAVLLYNQGEKKNALAQYQEMEKKVSLLKDNS 409
Query: 714 YMHYGQFLLEEARLIEAA 731
+ + ++E A+ + AA
Sbjct: 410 SLEFDSEMVEMAQKLGAA 427
>gi|41871960 kinesin-like 8 isoform b [Homo sapiens]
Length = 637
Score = 50.4 bits (119), Expect = 7e-06
Identities = 42/159 (26%), Positives = 67/159 (42%), Gaps = 16/159 (10%)
Query: 525 NMADMLYNLGLLLQENSRFAEALHYYKLAIGSR--------PTLASAYLNTGIILMNQGR 576
++A ML L L+ ++ +++ EA H A+ R P +A+ N ++ +G+
Sbjct: 269 DVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGK 328
Query: 577 TEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKM 636
+EA + EI ++ L H V L NL L QG YE Y+ A+
Sbjct: 329 YKEAEPLCQRALEIREKVLGTNHP---DVAKQLNNLALLCQNQGKYEAVERYYQRALAIY 385
Query: 637 PRQFAPQS-----LYNMMGEAYMRLSKLPEAEHWYMESL 670
Q P + N + Y++ K EAE Y E L
Sbjct: 386 EGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 424
Score = 44.7 bits (104), Expect = 4e-04
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 19/153 (12%)
Query: 499 LGNVLKSQSKISEAESAYRNALYYRSN--------MADMLYNLGLLLQENSRFAEALHYY 550
L V + Q+K EA +AL R + +A L NL +L + ++ EA
Sbjct: 277 LALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLC 336
Query: 551 KLAIGSR--------PTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHK 602
+ A+ R P +A N ++ NQG+ E R + + I + L + +
Sbjct: 337 QRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDNPNV 396
Query: 603 SSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
+ + NL Y +QG Y EA ++YKE + +
Sbjct: 397 ARTKN---NLASCYLKQGKYAEAETLYKEILTR 426
Score = 40.8 bits (94), Expect = 0.005
Identities = 53/219 (24%), Positives = 84/219 (38%), Gaps = 47/219 (21%)
Query: 609 LYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFA-----PQSLYNMMGEAYMRLSKLPEAE 663
L+NL Y QG YE A+ + K+A++ + R ++ N++ Y +K EA
Sbjct: 232 LHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAA 291
Query: 664 HWYME--SLRSKT---DHIPAHLTYGKLLALTGRK---SEAEKLFLKAIELDPTKGNCYM 715
H + S+R T DH T L L G++ EAE L +A+E
Sbjct: 292 HLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALE---------- 341
Query: 716 HYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARL- 774
+ E+ ++AK+ + N A + + EA E+YY A +
Sbjct: 342 -----IREKVLGTNHPDVAKQ-----------LNNLALLCQNQGKYEAVERYYQRALAIY 385
Query: 775 -------RPNYPAALMNLGAILHLNGRLQKAEANYLRAL 806
PN NL + G+ +AE Y L
Sbjct: 386 EGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 424
Score = 30.0 bits (66), Expect = 9.3
Identities = 27/115 (23%), Positives = 47/115 (40%), Gaps = 18/115 (15%)
Query: 491 NPAKAWGNLGNVLKSQSKISEAESAYRNALYYR-----SNMADMLYNLGLLLQENSRFAE 545
N A+ NL + Q K +EAE+ Y+ L ++ D + + +E ++
Sbjct: 395 NVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREEMSK 454
Query: 546 ALHY------------YKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCS 588
+ H+ YK S PT+ + N G + QG+ EA T +C+
Sbjct: 455 SRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKL-EAAETLEECA 508
>gi|41871955 kinesin-like 8 isoform a [Homo sapiens]
Length = 619
Score = 50.4 bits (119), Expect = 7e-06
Identities = 42/159 (26%), Positives = 67/159 (42%), Gaps = 16/159 (10%)
Query: 525 NMADMLYNLGLLLQENSRFAEALHYYKLAIGSR--------PTLASAYLNTGIILMNQGR 576
++A ML L L+ ++ +++ EA H A+ R P +A+ N ++ +G+
Sbjct: 251 DVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGK 310
Query: 577 TEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKM 636
+EA + EI ++ L H V L NL L QG YE Y+ A+
Sbjct: 311 YKEAEPLCQRALEIREKVLGTNHP---DVAKQLNNLALLCQNQGKYEAVERYYQRALAIY 367
Query: 637 PRQFAPQS-----LYNMMGEAYMRLSKLPEAEHWYMESL 670
Q P + N + Y++ K EAE Y E L
Sbjct: 368 EGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 406
Score = 44.7 bits (104), Expect = 4e-04
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 19/153 (12%)
Query: 499 LGNVLKSQSKISEAESAYRNALYYRSN--------MADMLYNLGLLLQENSRFAEALHYY 550
L V + Q+K EA +AL R + +A L NL +L + ++ EA
Sbjct: 259 LALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLC 318
Query: 551 KLAIGSR--------PTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHK 602
+ A+ R P +A N ++ NQG+ E R + + I + L + +
Sbjct: 319 QRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDNPNV 378
Query: 603 SSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
+ + NL Y +QG Y EA ++YKE + +
Sbjct: 379 ARTKN---NLASCYLKQGKYAEAETLYKEILTR 408
Score = 40.8 bits (94), Expect = 0.005
Identities = 53/219 (24%), Positives = 84/219 (38%), Gaps = 47/219 (21%)
Query: 609 LYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFA-----PQSLYNMMGEAYMRLSKLPEAE 663
L+NL Y QG YE A+ + K+A++ + R ++ N++ Y +K EA
Sbjct: 214 LHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAA 273
Query: 664 HWYME--SLRSKT---DHIPAHLTYGKLLALTGRK---SEAEKLFLKAIELDPTKGNCYM 715
H + S+R T DH T L L G++ EAE L +A+E
Sbjct: 274 HLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALE---------- 323
Query: 716 HYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARL- 774
+ E+ ++AK+ + N A + + EA E+YY A +
Sbjct: 324 -----IREKVLGTNHPDVAKQ-----------LNNLALLCQNQGKYEAVERYYQRALAIY 367
Query: 775 -------RPNYPAALMNLGAILHLNGRLQKAEANYLRAL 806
PN NL + G+ +AE Y L
Sbjct: 368 EGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 406
Score = 30.0 bits (66), Expect = 9.3
Identities = 27/115 (23%), Positives = 47/115 (40%), Gaps = 18/115 (15%)
Query: 491 NPAKAWGNLGNVLKSQSKISEAESAYRNALYYR-----SNMADMLYNLGLLLQENSRFAE 545
N A+ NL + Q K +EAE+ Y+ L ++ D + + +E ++
Sbjct: 377 NVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREEMSK 436
Query: 546 ALHY------------YKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCS 588
+ H+ YK S PT+ + N G + QG+ EA T +C+
Sbjct: 437 SRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKL-EAAETLEECA 490
>gi|41871946 kinesin-like 8 isoform a [Homo sapiens]
Length = 619
Score = 50.4 bits (119), Expect = 7e-06
Identities = 42/159 (26%), Positives = 67/159 (42%), Gaps = 16/159 (10%)
Query: 525 NMADMLYNLGLLLQENSRFAEALHYYKLAIGSR--------PTLASAYLNTGIILMNQGR 576
++A ML L L+ ++ +++ EA H A+ R P +A+ N ++ +G+
Sbjct: 251 DVATMLNILALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGK 310
Query: 577 TEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKM 636
+EA + EI ++ L H V L NL L QG YE Y+ A+
Sbjct: 311 YKEAEPLCQRALEIREKVLGTNHP---DVAKQLNNLALLCQNQGKYEAVERYYQRALAIY 367
Query: 637 PRQFAPQS-----LYNMMGEAYMRLSKLPEAEHWYMESL 670
Q P + N + Y++ K EAE Y E L
Sbjct: 368 EGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 406
Score = 44.7 bits (104), Expect = 4e-04
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 19/153 (12%)
Query: 499 LGNVLKSQSKISEAESAYRNALYYRSN--------MADMLYNLGLLLQENSRFAEALHYY 550
L V + Q+K EA +AL R + +A L NL +L + ++ EA
Sbjct: 259 LALVYRDQNKYKEAAHLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLC 318
Query: 551 KLAIGSR--------PTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHK 602
+ A+ R P +A N ++ NQG+ E R + + I + L + +
Sbjct: 319 QRALEIREKVLGTNHPDVAKQLNNLALLCQNQGKYEAVERYYQRALAIYEGQLGPDNPNV 378
Query: 603 SSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
+ + NL Y +QG Y EA ++YKE + +
Sbjct: 379 ARTKN---NLASCYLKQGKYAEAETLYKEILTR 408
Score = 40.8 bits (94), Expect = 0.005
Identities = 53/219 (24%), Positives = 84/219 (38%), Gaps = 47/219 (21%)
Query: 609 LYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFA-----PQSLYNMMGEAYMRLSKLPEAE 663
L+NL Y QG YE A+ + K+A++ + R ++ N++ Y +K EA
Sbjct: 214 LHNLVIQYAAQGRYEVAVPLCKQALEDLERTSGRGHPDVATMLNILALVYRDQNKYKEAA 273
Query: 664 HWYME--SLRSKT---DHIPAHLTYGKLLALTGRK---SEAEKLFLKAIELDPTKGNCYM 715
H + S+R T DH T L L G++ EAE L +A+E
Sbjct: 274 HLLNDALSIRESTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCQRALE---------- 323
Query: 716 HYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARL- 774
+ E+ ++AK+ + N A + + EA E+YY A +
Sbjct: 324 -----IREKVLGTNHPDVAKQ-----------LNNLALLCQNQGKYEAVERYYQRALAIY 367
Query: 775 -------RPNYPAALMNLGAILHLNGRLQKAEANYLRAL 806
PN NL + G+ +AE Y L
Sbjct: 368 EGQLGPDNPNVARTKNNLASCYLKQGKYAEAETLYKEIL 406
Score = 30.0 bits (66), Expect = 9.3
Identities = 27/115 (23%), Positives = 47/115 (40%), Gaps = 18/115 (15%)
Query: 491 NPAKAWGNLGNVLKSQSKISEAESAYRNALYYR-----SNMADMLYNLGLLLQENSRFAE 545
N A+ NL + Q K +EAE+ Y+ L ++ D + + +E ++
Sbjct: 377 NVARTKNNLASCYLKQGKYAEAETLYKEILTRAHVQEFGSVDDDHKPIWMHAEEREEMSK 436
Query: 546 ALHY------------YKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCS 588
+ H+ YK S PT+ + N G + QG+ EA T +C+
Sbjct: 437 SRHHEGGTPYAEYGGWYKACKVSSPTVNTTLRNLGALYRRQGKL-EAAETLEECA 490
>gi|198041734 kinesin light chain 2 isoform 1 [Homo sapiens]
Length = 622
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/155 (27%), Positives = 67/155 (43%), Gaps = 23/155 (14%)
Query: 499 LGNVLKSQSKISEAESAYRNALYYRSN--------MADMLYNLGLLLQENSRFAEALHYY 550
L V + Q+K EA +AL R +A L NL +L + ++ EA
Sbjct: 246 LALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLC 305
Query: 551 KLAIGSR--------PTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENL--KDPHA 600
K A+ R P +A N ++ NQG+ EE + + EI L DP+
Sbjct: 306 KRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNV 365
Query: 601 HKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
K+ NL Y +QG Y++A ++YKE + +
Sbjct: 366 AKTK-----NNLASCYLKQGKYQDAETLYKEILTR 395
Score = 40.4 bits (93), Expect = 0.007
Identities = 33/111 (29%), Positives = 53/111 (47%), Gaps = 13/111 (11%)
Query: 609 LYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQ-----SLYNMMGEAYMRLSKLPEAE 663
L+NL Y QG YE A+ + K+A++ + + ++ N++ Y +K EA
Sbjct: 201 LHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAA 260
Query: 664 HWYMESL--RSKT---DHIPAHLTYGKLLALTGRK---SEAEKLFLKAIEL 706
H ++L R KT DH T L L G++ EAE L +A+E+
Sbjct: 261 HLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEI 311
Score = 30.4 bits (67), Expect = 7.1
Identities = 43/186 (23%), Positives = 68/186 (36%), Gaps = 27/186 (14%)
Query: 462 LIVFYGLKTAIRNGDWQNEEMLYRSGIKVNP----------AKAWGNLGNVLKSQSKISE 511
L V YG + G ++ E L + +++ AK NL + ++Q K E
Sbjct: 288 LAVLYG-----KRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEE 342
Query: 512 AESAYRNALYYRS--------NMADMLYNLGLLLQENSRFAEALHYYK--LAIGSRPTLA 561
E YR AL + N+A NL + ++ +A YK L
Sbjct: 343 VEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFG 402
Query: 562 SAYLNTGIILMNQGRTEEARRTFLKCSEIPDEN--LKDPHAHKSSVTSCLYNLGKLYHEQ 619
S + I M+ EE++ + + K +V + L +LG LY Q
Sbjct: 403 SVNGDNKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQ 462
Query: 620 GHYEEA 625
G E A
Sbjct: 463 GKLEAA 468
>gi|198041731 kinesin light chain 2 isoform 1 [Homo sapiens]
Length = 622
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/155 (27%), Positives = 67/155 (43%), Gaps = 23/155 (14%)
Query: 499 LGNVLKSQSKISEAESAYRNALYYRSN--------MADMLYNLGLLLQENSRFAEALHYY 550
L V + Q+K EA +AL R +A L NL +L + ++ EA
Sbjct: 246 LALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLC 305
Query: 551 KLAIGSR--------PTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENL--KDPHA 600
K A+ R P +A N ++ NQG+ EE + + EI L DP+
Sbjct: 306 KRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNV 365
Query: 601 HKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
K+ NL Y +QG Y++A ++YKE + +
Sbjct: 366 AKTK-----NNLASCYLKQGKYQDAETLYKEILTR 395
Score = 40.4 bits (93), Expect = 0.007
Identities = 33/111 (29%), Positives = 53/111 (47%), Gaps = 13/111 (11%)
Query: 609 LYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQ-----SLYNMMGEAYMRLSKLPEAE 663
L+NL Y QG YE A+ + K+A++ + + ++ N++ Y +K EA
Sbjct: 201 LHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAA 260
Query: 664 HWYMESL--RSKT---DHIPAHLTYGKLLALTGRK---SEAEKLFLKAIEL 706
H ++L R KT DH T L L G++ EAE L +A+E+
Sbjct: 261 HLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEI 311
Score = 30.4 bits (67), Expect = 7.1
Identities = 43/186 (23%), Positives = 68/186 (36%), Gaps = 27/186 (14%)
Query: 462 LIVFYGLKTAIRNGDWQNEEMLYRSGIKVNP----------AKAWGNLGNVLKSQSKISE 511
L V YG + G ++ E L + +++ AK NL + ++Q K E
Sbjct: 288 LAVLYG-----KRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEE 342
Query: 512 AESAYRNALYYRS--------NMADMLYNLGLLLQENSRFAEALHYYK--LAIGSRPTLA 561
E YR AL + N+A NL + ++ +A YK L
Sbjct: 343 VEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFG 402
Query: 562 SAYLNTGIILMNQGRTEEARRTFLKCSEIPDEN--LKDPHAHKSSVTSCLYNLGKLYHEQ 619
S + I M+ EE++ + + K +V + L +LG LY Q
Sbjct: 403 SVNGDNKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQ 462
Query: 620 GHYEEA 625
G E A
Sbjct: 463 GKLEAA 468
>gi|198041728 kinesin light chain 2 isoform 2 [Homo sapiens]
Length = 545
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/155 (27%), Positives = 67/155 (43%), Gaps = 23/155 (14%)
Query: 499 LGNVLKSQSKISEAESAYRNALYYRSN--------MADMLYNLGLLLQENSRFAEALHYY 550
L V + Q+K EA +AL R +A L NL +L + ++ EA
Sbjct: 169 LALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLC 228
Query: 551 KLAIGSR--------PTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENL--KDPHA 600
K A+ R P +A N ++ NQG+ EE + + EI L DP+
Sbjct: 229 KRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNV 288
Query: 601 HKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
K+ NL Y +QG Y++A ++YKE + +
Sbjct: 289 AKTK-----NNLASCYLKQGKYQDAETLYKEILTR 318
Score = 40.4 bits (93), Expect = 0.007
Identities = 33/111 (29%), Positives = 53/111 (47%), Gaps = 13/111 (11%)
Query: 609 LYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQ-----SLYNMMGEAYMRLSKLPEAE 663
L+NL Y QG YE A+ + K+A++ + + ++ N++ Y +K EA
Sbjct: 124 LHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAA 183
Query: 664 HWYMESL--RSKT---DHIPAHLTYGKLLALTGRK---SEAEKLFLKAIEL 706
H ++L R KT DH T L L G++ EAE L +A+E+
Sbjct: 184 HLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEI 234
Score = 30.4 bits (67), Expect = 7.1
Identities = 43/186 (23%), Positives = 68/186 (36%), Gaps = 27/186 (14%)
Query: 462 LIVFYGLKTAIRNGDWQNEEMLYRSGIKVNP----------AKAWGNLGNVLKSQSKISE 511
L V YG + G ++ E L + +++ AK NL + ++Q K E
Sbjct: 211 LAVLYG-----KRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEE 265
Query: 512 AESAYRNALYYRS--------NMADMLYNLGLLLQENSRFAEALHYYK--LAIGSRPTLA 561
E YR AL + N+A NL + ++ +A YK L
Sbjct: 266 VEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFG 325
Query: 562 SAYLNTGIILMNQGRTEEARRTFLKCSEIPDEN--LKDPHAHKSSVTSCLYNLGKLYHEQ 619
S + I M+ EE++ + + K +V + L +LG LY Q
Sbjct: 326 SVNGDNKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQ 385
Query: 620 GHYEEA 625
G E A
Sbjct: 386 GKLEAA 391
>gi|12383062 kinesin light chain 2 isoform 1 [Homo sapiens]
Length = 622
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/155 (27%), Positives = 67/155 (43%), Gaps = 23/155 (14%)
Query: 499 LGNVLKSQSKISEAESAYRNALYYRSN--------MADMLYNLGLLLQENSRFAEALHYY 550
L V + Q+K EA +AL R +A L NL +L + ++ EA
Sbjct: 246 LALVYRDQNKYKEAAHLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLC 305
Query: 551 KLAIGSR--------PTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENL--KDPHA 600
K A+ R P +A N ++ NQG+ EE + + EI L DP+
Sbjct: 306 KRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEEVEYYYRRALEIYATRLGPDDPNV 365
Query: 601 HKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
K+ NL Y +QG Y++A ++YKE + +
Sbjct: 366 AKTK-----NNLASCYLKQGKYQDAETLYKEILTR 395
Score = 40.4 bits (93), Expect = 0.007
Identities = 33/111 (29%), Positives = 53/111 (47%), Gaps = 13/111 (11%)
Query: 609 LYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQ-----SLYNMMGEAYMRLSKLPEAE 663
L+NL Y QG YE A+ + K+A++ + + ++ N++ Y +K EA
Sbjct: 201 LHNLVIQYASQGRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAA 260
Query: 664 HWYMESL--RSKT---DHIPAHLTYGKLLALTGRK---SEAEKLFLKAIEL 706
H ++L R KT DH T L L G++ EAE L +A+E+
Sbjct: 261 HLLNDALAIREKTLGKDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEI 311
Score = 30.4 bits (67), Expect = 7.1
Identities = 43/186 (23%), Positives = 68/186 (36%), Gaps = 27/186 (14%)
Query: 462 LIVFYGLKTAIRNGDWQNEEMLYRSGIKVNP----------AKAWGNLGNVLKSQSKISE 511
L V YG + G ++ E L + +++ AK NL + ++Q K E
Sbjct: 288 LAVLYG-----KRGKYKEAEPLCKRALEIREKVLGKFHPDVAKQLSNLALLCQNQGKAEE 342
Query: 512 AESAYRNALYYRS--------NMADMLYNLGLLLQENSRFAEALHYYK--LAIGSRPTLA 561
E YR AL + N+A NL + ++ +A YK L
Sbjct: 343 VEYYYRRALEIYATRLGPDDPNVAKTKNNLASCYLKQGKYQDAETLYKEILTRAHEKEFG 402
Query: 562 SAYLNTGIILMNQGRTEEARRTFLKCSEIPDEN--LKDPHAHKSSVTSCLYNLGKLYHEQ 619
S + I M+ EE++ + + K +V + L +LG LY Q
Sbjct: 403 SVNGDNKPIWMHAEEREESKDKRRDSAPYGEYGSWYKACKVDSPTVNTTLRSLGALYRRQ 462
Query: 620 GHYEEA 625
G E A
Sbjct: 463 GKLEAA 468
>gi|91825557 kinesin light chain 3 [Homo sapiens]
Length = 504
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/153 (28%), Positives = 65/153 (42%), Gaps = 19/153 (12%)
Query: 499 LGNVLKSQSKISEAESAYRNALYYRSN--------MADMLYNLGLLLQENSRFAEALHYY 550
L V + Q+K EA +AL R +A L NL +L + R+ EA
Sbjct: 255 LALVYRDQNKYKEATDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLC 314
Query: 551 KLAIGSR--------PTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHK 602
+ A+ R P +A N ++ NQG+ E+ R + + I E L PH
Sbjct: 315 QRALEIREKVLGADHPDVAKQLNNLALLCQNQGKFEDVERHYARALSIY-EALGGPH--D 371
Query: 603 SSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
+V NL Y +Q Y++A +YKE + K
Sbjct: 372 PNVAKTKNNLASAYLKQNKYQQAEELYKEILHK 404
Score = 33.1 bits (74), Expect = 1.1
Identities = 28/111 (25%), Positives = 51/111 (45%), Gaps = 13/111 (11%)
Query: 609 LYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFA-----PQSLYNMMGEAYMRLSKLPEAE 663
L+NL Y QG YE A+ + ++A++ + R ++ N++ Y +K EA
Sbjct: 210 LHNLVIQYAGQGRYEVAVPLCRQALEDLERSSGHCHPDVATMLNILALVYRDQNKYKEAT 269
Query: 664 HWYMESLRSK-----TDHIPAHLTYGKLLALTGRKS---EAEKLFLKAIEL 706
++L+ + +H T L L G++ EAE L +A+E+
Sbjct: 270 DLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEI 320
Score = 30.4 bits (67), Expect = 7.1
Identities = 56/263 (21%), Positives = 95/263 (36%), Gaps = 42/263 (15%)
Query: 566 NTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEA 625
N I QGR E A + E D H H V + L L +Y +Q Y+EA
Sbjct: 212 NLVIQYAGQGRYEVAVPLCRQALE--DLERSSGHCHPD-VATMLNILALVYRDQNKYKEA 268
Query: 626 LSVYKEAIQKMPRQFAPQ-----SLYNMMGEAYMRLSKLPEAEHWYMESLRSK-----TD 675
+ +A+Q + P+ + N + Y + + EAE +L + D
Sbjct: 269 TDLLHDALQIREQTLGPEHPAVAATLNNLAVLYGKRGRYREAEPLCQRALEIREKVLGAD 328
Query: 676 HIPAHLTYGKLLAL---TGRKSEAEKLFLKAIEL--------DPTKGNCYMHYGQFLLEE 724
H L L G+ + E+ + +A+ + DP + L++
Sbjct: 329 HPDVAKQLNNLALLCQNQGKFEDVERHYARALSIYEALGGPHDPNVAKTKNNLASAYLKQ 388
Query: 725 ARLIEAAEMAKK-------AAELDSTEFDVVFNAAHMLRQA--------SLNEAAEKYYD 769
+ +A E+ K+ A L + +A LR++ S+ +EK
Sbjct: 389 NKYQQAEELYKEILHKEDLPAPLGAPNTGTAGDAEQALRRSSSLSKIRESIRRGSEK--- 445
Query: 770 LAARLRPNYPAALMNLGAILHLN 792
L +RLR A + + LN
Sbjct: 446 LVSRLRGEAAAGAAGMKRAMSLN 468
>gi|116534937 interferon-induced protein with tetratricopeptide
repeats 1 isoform 2 [Homo sapiens]
Length = 478
Score = 47.4 bits (111), Expect = 6e-05
Identities = 55/246 (22%), Positives = 102/246 (41%), Gaps = 39/246 (15%)
Query: 592 DENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGE 651
++ +++ A+ SS T K Y +G ++AL + K+A+Q+ P L++ +G
Sbjct: 237 EKYIEEALANMSSQTYVFRYAAKFYRRKGSVDKALELLKKALQETPTSVL---LHHQIGL 293
Query: 652 AYM--------------------RLSKLPEAEHWYMES-LRSKTDHIPAHLTYGKLLALT 690
Y +L K+ + ++ ES + K AHL ++
Sbjct: 294 CYKAQMIQIKEATKGQPRGQNREKLDKMIRSAIFHFESAVEKKPTFEVAHLDLARMYIEA 353
Query: 691 GRKSEAEKLFLKAIELDP----TKGNCYMHYGQFL-LEEARLIEAAEMAKKAAELDSTEF 745
G +AE+ F K + + P T + + HYG+F ++ + A KA +++
Sbjct: 354 GNHRKAEENFQKLLCMKPVVEETMQDIHFHYGRFQEFQKKSDVNAIIHYLKAIKIEQASL 413
Query: 746 DVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRA 805
+ + L++ L + K DL +L LG + L G + +A Y RA
Sbjct: 414 -TRDKSINSLKKLVLRKLRRKALDL---------ESLSLLGFVYKLEGNMNEALEYYERA 463
Query: 806 LQLKPD 811
L+L D
Sbjct: 464 LRLAAD 469
>gi|170784869 tetratricopeptide repeat domain 13 isoform b [Homo
sapiens]
Length = 807
Score = 46.2 bits (108), Expect = 1e-04
Identities = 53/212 (25%), Positives = 87/212 (41%), Gaps = 29/212 (13%)
Query: 516 YRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQG 575
Y A+ + S M +L LG R EA++ AI +P+ A Y + G +
Sbjct: 159 YDEAIRHFSTMLQILSPLG-------RINEAVNDLTKAIQLQPS-ARLYRHRGTLYFISE 210
Query: 576 RTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
A F + E+ +K+ + LY G + +G +EA+ +KEA+ K
Sbjct: 211 DYATAHEDFQQSLEL----------NKNQPIAMLYK-GLTFFHRGLLKEAIESFKEAL-K 258
Query: 636 MPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSE 695
F Y +G+AY L A + ++L +H+ G +L G E
Sbjct: 259 QKVDFI--DAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQE 316
Query: 696 AEKLFLKAIELDP-------TKGNCYMHYGQF 720
A K F + ++L+P KG ++ GQF
Sbjct: 317 ALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQF 348
Score = 35.0 bits (79), Expect = 0.29
Identities = 32/129 (24%), Positives = 52/129 (40%), Gaps = 3/129 (2%)
Query: 613 GKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRS 672
G LY Y A ++++++ Q LY G + L EA + E+L+
Sbjct: 203 GTLYFISEDYATAHEDFQQSLELNKNQPIAM-LYK--GLTFFHRGLLKEAIESFKEALKQ 259
Query: 673 KTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAE 732
K D I A+ + G+ G A + F KA+ L+ G L L EA +
Sbjct: 260 KVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQTLQLRGMMLYHHGSLQEALK 319
Query: 733 MAKKAAELD 741
K+ +L+
Sbjct: 320 NFKRCLQLE 328
Score = 32.7 bits (73), Expect = 1.4
Identities = 43/212 (20%), Positives = 78/212 (36%), Gaps = 29/212 (13%)
Query: 488 IKVNP-AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEA 546
I++ P A+ + + G + + A ++ +L N + GL EA
Sbjct: 190 IQLQPSARLYRHRGTLYFISEDYATAHEDFQQSLELNKNQPIAMLYKGLTFFHRGLLKEA 249
Query: 547 LHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVT 606
+ +K A+ + AY + G G E A +F K + +++
Sbjct: 250 IESFKEALKQKVDFIDAYKSLGQAYRELGNFEAATESFQKALLLNQNHVQ---------- 299
Query: 607 SCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNM----MGEAY--------- 653
L G + + G +EAL +K +Q P Q + + MG+ Y
Sbjct: 300 -TLQLRGMMLYHHGSLQEALKNFKRCLQLEPYNEVCQYMKGLSHVAMGQFYEGIKAQTKV 358
Query: 654 MRLSKLP----EAEHWYMESLRSKTDHIPAHL 681
M LP E+ ++ LR + ++ AHL
Sbjct: 359 MLNDPLPGQKASPEYLKVKYLREYSRYLHAHL 390
>gi|221219053 DnaJ (Hsp40) homolog, subfamily C, member 7 isoform 1
[Homo sapiens]
Length = 494
Score = 45.1 bits (105), Expect = 3e-04
Identities = 58/239 (24%), Positives = 87/239 (36%), Gaps = 33/239 (13%)
Query: 593 ENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEA 652
E L D A + + T G Y+ + Y EA + Y +AI P+ S Y
Sbjct: 17 ELLDDQEAKREAET--FKEQGNAYYAKKDYNEAYNYYTKAIDMCPKN---ASYYGNRAAT 71
Query: 653 YMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGN 712
M L + EA +S+R + HL GK G A + F +A+ELD
Sbjct: 72 LMMLGRFREALGDAQQSVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELD----- 126
Query: 713 CYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAA 772
H +E + A +K AE D + D M R A ++ L A
Sbjct: 127 ---HKNAQAQQEFKNANAVMEYEKIAETDFEKRDFRKVVFCMDRALEFAPACHRFKILKA 183
Query: 773 R---LRPNYPAA-----------------LMNLGAILHLNGRLQKAEANYLRALQLKPD 811
+ YP A L G L+ ++KA +++AL++ PD
Sbjct: 184 ECLAMLGRYPEAQSVASDILRMDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPD 242
Score = 40.8 bits (94), Expect = 0.005
Identities = 61/328 (18%), Positives = 112/328 (34%), Gaps = 54/328 (16%)
Query: 493 AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKL 552
A+ + GN ++ +EA + Y A+ A N L RF EAL +
Sbjct: 28 AETFKEQGNAYYAKKDYNEAYNYYTKAIDMCPKNASYYGNRAATLMMLGRFREALGDAQQ 87
Query: 553 AIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLY-N 611
++ + +L G ++ G A R+F + E+ +N + K++ Y
Sbjct: 88 SVRLDDSFVRGHLREGKCHLSLGNAMAACRSFQRALELDHKNAQAQQEFKNANAVMEYEK 147
Query: 612 LGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAE-------- 663
+ + E+ + + + A++ P A + E L + PEA+
Sbjct: 148 IAETDFEKRDFRKVVFCMDRALEFAP---ACHRFKILKAECLAMLGRYPEAQSVASDILR 204
Query: 664 --------------------------HWYMESLRSKTDHIPAHLTYGKLLALTGRKSEAE 697
+++++LR DH A + AL +K +
Sbjct: 205 MDSTNADALYVRGLCLYYEDCIEKAVQFFVQALRMAPDHEKACIACRNAKALKAKKEDGN 264
Query: 698 K------------LFLKAIELDP----TKGNCYMHYGQFLLEEARLIEAAEMAKKAAELD 741
K L+ +A+ +DP T Y + G + +L +A E A +LD
Sbjct: 265 KAFKEGNYKLAYELYTEALGIDPNNIKTNAKLYCNRGTVNSKLRKLDDAIEDCTNAVKLD 324
Query: 742 STEFDVVFNAAHMLRQASLNEAAEKYYD 769
T A E A + Y+
Sbjct: 325 DTYIKAYLRRAQCYMDTEQYEEAVRDYE 352
>gi|167466177 cell division cycle protein 27 isoform 1 [Homo
sapiens]
Length = 830
Score = 45.1 bits (105), Expect = 3e-04
Identities = 36/177 (20%), Positives = 80/177 (45%), Gaps = 16/177 (9%)
Query: 484 YRSGIKVNP--AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENS 541
++ I+V+P A A+ LG+ ++ +A + +RNA+ + Y LG++ +
Sbjct: 596 FQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQE 655
Query: 542 RFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAH 601
+F+ A +++ A+ P + + G++ ++E+A T K I +N
Sbjct: 656 KFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKN------- 708
Query: 602 KSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSK 658
C ++ + Y+ AL +E Q +P++ +Y ++G+ Y +L +
Sbjct: 709 ----PLCKFHRASVLFANEKYKSALQELEELKQIVPKE---SLVYFLIGKVYKKLGQ 758
Score = 37.0 bits (84), Expect = 0.076
Identities = 40/212 (18%), Positives = 78/212 (36%), Gaps = 5/212 (2%)
Query: 600 AHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKL 659
+H + L +G+ Y E Y +A ++ E + + +Y+ L K
Sbjct: 499 SHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYST---TLWHLQK- 554
Query: 660 PEAEHWYMESLRSKTDHIP-AHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYG 718
A + L + P A G +L A K F +AI++DP Y G
Sbjct: 555 DVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLG 614
Query: 719 QFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNY 778
+ L +A + A ++ ++ + + + AE ++ A + P
Sbjct: 615 HEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQS 674
Query: 779 PAALMNLGAILHLNGRLQKAEANYLRALQLKP 810
L ++G + H + +KA +A+ + P
Sbjct: 675 SVLLCHIGVVQHALKKSEKALDTLNKAIVIDP 706
Score = 35.0 bits (79), Expect = 0.29
Identities = 56/226 (24%), Positives = 87/226 (38%), Gaps = 22/226 (9%)
Query: 491 NPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYY 550
N +AW GN Q + A ++ A+ N A LG +AL +
Sbjct: 571 NSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACF 630
Query: 551 KLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLY 610
+ AI P +A+ G+I Q + A F K +I + SSV C
Sbjct: 631 RNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQ---------SSVLLC-- 679
Query: 611 NLGKLYHEQGHYEEALSVYKEAIQKMPR----QFAPQSLYNMMGEAYMRLSKLPEAEHWY 666
++G + H E+AL +AI P+ +F S+ E Y S L E E
Sbjct: 680 HIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVL-FANEKYK--SALQELEE-- 734
Query: 667 MESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGN 712
++ + K + + GK+ G+ A F A++LDP N
Sbjct: 735 LKQIVPKESLV--YFLIGKVYKKLGQTHLALMNFSWAMDLDPKGAN 778
Score = 30.4 bits (67), Expect = 7.1
Identities = 30/154 (19%), Positives = 58/154 (37%), Gaps = 3/154 (1%)
Query: 623 EEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLT 682
++AL+ ++ AI+ PR + + + +G Y + K AE + ++L
Sbjct: 624 DKALACFRNAIRVNPRHY---NAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCH 680
Query: 683 YGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDS 742
G + + +A KAI +DP C H L + A + ++ ++
Sbjct: 681 IGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVP 740
Query: 743 TEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRP 776
E V F + ++ A + A L P
Sbjct: 741 KESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDP 774
>gi|167466175 cell division cycle protein 27 isoform 2 [Homo
sapiens]
Length = 824
Score = 45.1 bits (105), Expect = 3e-04
Identities = 36/177 (20%), Positives = 80/177 (45%), Gaps = 16/177 (9%)
Query: 484 YRSGIKVNP--AKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENS 541
++ I+V+P A A+ LG+ ++ +A + +RNA+ + Y LG++ +
Sbjct: 590 FQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQE 649
Query: 542 RFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAH 601
+F+ A +++ A+ P + + G++ ++E+A T K I +N
Sbjct: 650 KFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKN------- 702
Query: 602 KSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSK 658
C ++ + Y+ AL +E Q +P++ +Y ++G+ Y +L +
Sbjct: 703 ----PLCKFHRASVLFANEKYKSALQELEELKQIVPKE---SLVYFLIGKVYKKLGQ 752
Score = 37.0 bits (84), Expect = 0.076
Identities = 40/212 (18%), Positives = 78/212 (36%), Gaps = 5/212 (2%)
Query: 600 AHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKL 659
+H + L +G+ Y E Y +A ++ E + + +Y+ L K
Sbjct: 493 SHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYST---TLWHLQK- 548
Query: 660 PEAEHWYMESLRSKTDHIP-AHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYG 718
A + L + P A G +L A K F +AI++DP Y G
Sbjct: 549 DVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLG 608
Query: 719 QFLLEEARLIEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNY 778
+ L +A + A ++ ++ + + + AE ++ A + P
Sbjct: 609 HEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQS 668
Query: 779 PAALMNLGAILHLNGRLQKAEANYLRALQLKP 810
L ++G + H + +KA +A+ + P
Sbjct: 669 SVLLCHIGVVQHALKKSEKALDTLNKAIVIDP 700
Score = 35.0 bits (79), Expect = 0.29
Identities = 56/226 (24%), Positives = 87/226 (38%), Gaps = 22/226 (9%)
Query: 491 NPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYY 550
N +AW GN Q + A ++ A+ N A LG +AL +
Sbjct: 565 NSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACF 624
Query: 551 KLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLY 610
+ AI P +A+ G+I Q + A F K +I + SSV C
Sbjct: 625 RNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQ---------SSVLLC-- 673
Query: 611 NLGKLYHEQGHYEEALSVYKEAIQKMPR----QFAPQSLYNMMGEAYMRLSKLPEAEHWY 666
++G + H E+AL +AI P+ +F S+ E Y S L E E
Sbjct: 674 HIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVL-FANEKYK--SALQELEE-- 728
Query: 667 MESLRSKTDHIPAHLTYGKLLALTGRKSEAEKLFLKAIELDPTKGN 712
++ + K + + GK+ G+ A F A++LDP N
Sbjct: 729 LKQIVPKESLV--YFLIGKVYKKLGQTHLALMNFSWAMDLDPKGAN 772
Score = 30.4 bits (67), Expect = 7.1
Identities = 30/154 (19%), Positives = 58/154 (37%), Gaps = 3/154 (1%)
Query: 623 EEALSVYKEAIQKMPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLT 682
++AL+ ++ AI+ PR + + + +G Y + K AE + ++L
Sbjct: 618 DKALACFRNAIRVNPRHY---NAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCH 674
Query: 683 YGKLLALTGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDS 742
G + + +A KAI +DP C H L + A + ++ ++
Sbjct: 675 IGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVP 734
Query: 743 TEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRP 776
E V F + ++ A + A L P
Sbjct: 735 KESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDP 768
>gi|54607135 translocase of outer mitochondrial membrane 70 homolog
A [Homo sapiens]
Length = 608
Score = 43.9 bits (102), Expect = 6e-04
Identities = 53/248 (21%), Positives = 102/248 (41%), Gaps = 20/248 (8%)
Query: 527 ADMLYNLGLLLQENSRFAEALHYYKLAIGSRPTLASAYLNTGIILMNQGRTEEARRTFLK 586
A+ L G + + + + + +A P A Y + G + + + EEA F +
Sbjct: 367 ANALIKRGSMYMQQQQPLLSTQDFNMAADIDPQNADVYHHRGQLKILLDQVEEAVADFDE 426
Query: 587 CSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQKMPRQFAPQSLY 646
C + E+ ++ LY + + A+ ++E I+K PR +LY
Sbjct: 427 CIRLRPESA----LAQAQKCFALYRQAYTGNNSSQIQAAMKGFEEVIKKFPRCAEGYALY 482
Query: 647 NMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTYGKLLALTGRKS--EAEKLFLKAI 704
+A + +A+ Y + + + D+ ++ G LL L ++ +L KAI
Sbjct: 483 ---AQALTDQQQFGKADEMYDKCIDLEPDNATTYVHKG-LLQLQWKQDLDRGLELISKAI 538
Query: 705 ELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFDV-----VFNAAHMLRQAS 759
E+D Y G ++ + +A +M KA L +E ++ + +AAH +
Sbjct: 539 EIDNKCDFAYETMGTIEVQRGNMEKAIDMFNKAINLAKSEMEMAHLYSLCDAAH-----A 593
Query: 760 LNEAAEKY 767
E A+KY
Sbjct: 594 QTEVAKKY 601
>gi|157502179 tetratricopeptide repeat domain 21A isoform 1 [Homo
sapiens]
Length = 1321
Score = 43.9 bits (102), Expect = 6e-04
Identities = 67/262 (25%), Positives = 113/262 (43%), Gaps = 46/262 (17%)
Query: 576 RTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
+T RR +++C E+L PH TS L LG E+AL VY EA ++
Sbjct: 707 QTLRDRRLYIRCYRELCEHLPGPH------TSLL--LGDALMSILEPEKALEVYDEAYRQ 758
Query: 636 MPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLR-SKTDHIPAHLTYGKLLALTGRKS 694
P SL + +G AY++ + EA +Y + + + D + L GKLL + +
Sbjct: 759 NPHD---ASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDL--GKLLLKLKKVN 813
Query: 695 EAEKLFLKAIELD-----PTKGN---CYM--------HYGQFLLE--------EARL--- 727
+AEK+ +A+E D P+ N C + H + ++E ++R+
Sbjct: 814 KAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKR 873
Query: 728 --IEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNL 785
+E EM +L + + F A H L + ++A + Y D+ + L P ++ L
Sbjct: 874 VPLEQPEMIPSQKQL-AASICIQF-AEHYLAEKEYDKAVQSYKDVFSYL-PTDNKVMLEL 930
Query: 786 GAILHLNGRLQKAEANYLRALQ 807
+ L G L E + LQ
Sbjct: 931 AQLYLLQGHLDLCEQHCAILLQ 952
>gi|157502177 tetratricopeptide repeat domain 21A isoform 2 [Homo
sapiens]
Length = 1320
Score = 43.9 bits (102), Expect = 6e-04
Identities = 67/262 (25%), Positives = 113/262 (43%), Gaps = 46/262 (17%)
Query: 576 RTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGHYEEALSVYKEAIQK 635
+T RR +++C E+L PH TS L LG E+AL VY EA ++
Sbjct: 706 QTLRDRRLYIRCYRELCEHLPGPH------TSLL--LGDALMSILEPEKALEVYDEAYRQ 757
Query: 636 MPRQFAPQSLYNMMGEAYMRLSKLPEAEHWYMESLR-SKTDHIPAHLTYGKLLALTGRKS 694
P SL + +G AY++ + EA +Y + + + D + L GKLL + +
Sbjct: 758 NPHD---ASLASRIGHAYVKAHQYTEAIEYYEAAQKINGQDFLCCDL--GKLLLKLKKVN 812
Query: 695 EAEKLFLKAIELD-----PTKGN---CYM--------HYGQFLLE--------EARL--- 727
+AEK+ +A+E D P+ N C + H + ++E ++R+
Sbjct: 813 KAEKVLKQALEHDIVQDIPSMMNDVKCLLLLAKVYKSHKKEAVIETLNKALDLQSRILKR 872
Query: 728 --IEAAEMAKKAAELDSTEFDVVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNL 785
+E EM +L + + F A H L + ++A + Y D+ + L P ++ L
Sbjct: 873 VPLEQPEMIPSQKQL-AASICIQF-AEHYLAEKEYDKAVQSYKDVFSYL-PTDNKVMLEL 929
Query: 786 GAILHLNGRLQKAEANYLRALQ 807
+ L G L E + LQ
Sbjct: 930 AQLYLLQGHLDLCEQHCAILLQ 951
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,724,941
Number of Sequences: 37866
Number of extensions: 1205736
Number of successful extensions: 3529
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 65
Number of HSP's that attempted gapping in prelim test: 2903
Number of HSP's gapped (non-prelim): 412
length of query: 836
length of database: 18,247,518
effective HSP length: 111
effective length of query: 725
effective length of database: 14,044,392
effective search space: 10182184200
effective search space used: 10182184200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.