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Search of human proteins with 22749037
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22749037 WD repeat domain 65 [Homo sapiens]
(698 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22749037 WD repeat domain 65 [Homo sapiens] 1401 0.0
gi|31377846 WD repeat domain 52 [Homo sapiens] 77 5e-14
gi|223005862 echinoderm microtubule associated protein like 6 [H... 70 7e-12
gi|223029510 echinoderm microtubule associated protein like 4 is... 70 7e-12
gi|19923497 echinoderm microtubule associated protein like 4 iso... 70 7e-12
gi|34485720 echinoderm microtubule associated protein like 5 [Ho... 65 3e-10
gi|32189425 WD repeat domain 69 [Homo sapiens] 64 6e-10
gi|6912356 echinoderm microtubule associated protein like 2 [Hom... 64 6e-10
gi|26665869 WD repeat domain 51B [Homo sapiens] 59 1e-08
gi|110227615 echinoderm microtubule associated protein like 3 [H... 55 2e-07
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 55 2e-07
gi|21071067 TBP-associated factor 5 [Homo sapiens] 54 5e-07
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 54 6e-07
gi|113865883 WD repeat domain 38 [Homo sapiens] 54 6e-07
gi|94681049 hypothetical protein LOC80217 [Homo sapiens] 54 6e-07
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 52 1e-06
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 52 1e-06
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 52 1e-06
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 52 1e-06
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 52 2e-06
gi|56790932 echinoderm microtubule associated protein like 1 iso... 51 4e-06
gi|56790930 echinoderm microtubule associated protein like 1 iso... 51 4e-06
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 50 5e-06
gi|145279222 WD repeat domain 66 [Homo sapiens] 50 9e-06
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 50 9e-06
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 49 1e-05
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 49 1e-05
gi|148727341 serine/threonine kinase receptor associated protein... 49 1e-05
gi|23199987 WD repeat domain 5B [Homo sapiens] 49 1e-05
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 49 2e-05
>gi|22749037 WD repeat domain 65 [Homo sapiens]
Length = 698
Score = 1401 bits (3627), Expect = 0.0
Identities = 698/698 (100%), Positives = 698/698 (100%)
Query: 1 MSAVVAQTLHVFGLRSHVANNIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGM 60
MSAVVAQTLHVFGLRSHVANNIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGM
Sbjct: 1 MSAVVAQTLHVFGLRSHVANNIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGM 60
Query: 61 LALSISPNRRYLAISETVQEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSK 120
LALSISPNRRYLAISETVQEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSK
Sbjct: 61 LALSISPNRRYLAISETVQEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSK 120
Query: 121 YLLAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLL 180
YLLAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLL
Sbjct: 121 YLLAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLL 180
Query: 181 RFAEGTLKQTSFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPT 240
RFAEGTLKQTSFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPT
Sbjct: 181 RFAEGTLKQTSFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPT 240
Query: 241 NGSKSLDVIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAG 300
NGSKSLDVIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAG
Sbjct: 241 NGSKSLDVIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAG 300
Query: 301 PGRVLLFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKN 360
PGRVLLFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKN
Sbjct: 301 PGRVLLFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKN 360
Query: 361 QLYSITMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYET 420
QLYSITMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYET
Sbjct: 361 QLYSITMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYET 420
Query: 421 NTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDIRSFKEYSVRGCGECSFS 480
NTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDIRSFKEYSVRGCGECSFS
Sbjct: 421 NTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDIRSFKEYSVRGCGECSFS 480
Query: 481 NGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWN 540
NGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWN
Sbjct: 481 NGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWN 540
Query: 541 LSTGKRETECVLKSCSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAFDVTYTAI 600
LSTGKRETECVLKSCSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAFDVTYTAI
Sbjct: 541 LSTGKRETECVLKSCSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAFDVTYTAI 600
Query: 601 VISHSGRMMFVGTSVGTIRAMKYPLPLQKEFNEYQAHAGPITKVSRTLSPGTQSHTCLLR 660
VISHSGRMMFVGTSVGTIRAMKYPLPLQKEFNEYQAHAGPITKVSRTLSPGTQSHTCLLR
Sbjct: 601 VISHSGRMMFVGTSVGTIRAMKYPLPLQKEFNEYQAHAGPITKVSRTLSPGTQSHTCLLR 660
Query: 661 ALFIPSTSQCLFSLLLLSYLFIHHSLNHHLLTMNILFV 698
ALFIPSTSQCLFSLLLLSYLFIHHSLNHHLLTMNILFV
Sbjct: 661 ALFIPSTSQCLFSLLLLSYLFIHHSLNHHLLTMNILFV 698
>gi|31377846 WD repeat domain 52 [Homo sapiens]
Length = 982
Score = 77.0 bits (188), Expect = 5e-14
Identities = 114/545 (20%), Positives = 222/545 (40%), Gaps = 96/545 (17%)
Query: 9 LHVFGLRSHVANNIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPN 68
+H FG N+ D+ I I+ +GN + N+ K Q ++ S +G+ + + P+
Sbjct: 136 VHSFGYDCRKRANLQLLDDSIAIYIAGNQLIFLNLKTKEQIYLRSSS-GEGIGVIGVHPH 194
Query: 69 RRYLAISETVQEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSKYLLAQTSP 128
+ Y ++E P I IYE S+ R +VL D + + + F+ L + S
Sbjct: 195 KTYFTVAEK-GSFPDIIIYEYPSL--RPYRVLR--DGTEKGYAYVDFNYSGNLLASVGSN 249
Query: 129 PESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFA----- 183
P+ L W W++++ I+R + V++V+F+P Q+ +G+G K A
Sbjct: 250 PDYTLTIWNWKEEQ--PILRTKAFSQEVFKVTFNPDKEEQLTTSGSGHIKFWEMAFTFTG 307
Query: 184 ---EGTLKQTSFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPT 240
+G+L + F + + + + D K++ G++ G + L+E G I V+
Sbjct: 308 LKLQGSLGR--FGKTITTDIEGYMELPDGKVLSGSEWGNMLLWEGG------LIKVELCR 359
Query: 241 NGSKSLDVIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAG 300
SKS + P+ +Q+ + + I S G+
Sbjct: 360 GTSKSCH--------------NGPI------------NQIMLYEGEVITVGSDGYV---- 389
Query: 301 PGRVLLFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSE---ETLVAST 357
R+ FE ++ D E+ + I + + Q DK L +E +A
Sbjct: 390 --RIWDFETIDTADVIDETGLLEI----EPINELQVDKNVNLFSMIKMNETGNNFWLAQD 443
Query: 358 SKNQLYSITMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWN 417
+ ++ + +S + I++ F + HS I +A L+AT +LD S+R+++
Sbjct: 444 ANGAIWKLDLSFSNITQDPECLFSF-----HSGAIEAVAVSPLTYLMATTALDCSVRIYD 498
Query: 418 YETNTLELFKEYQEEAYSISLHP-----SGHFIVVGFADKLRLMNLLIDDIRSFKEYSVR 472
+ + T ++++ ++ P +G I+VGF D + +R + Y +
Sbjct: 499 FASKTPLAQMKFKQGGTALVWVPRMVNFTGAQIIVGFEDGV---------VRILELYDPK 549
Query: 473 GCGECSFSNGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGT 532
G +FA G + L+ + K HT + ++ + D L +G
Sbjct: 550 GL---------TIFA---GRKKILDADIQLKQV--FKPHTACVTALAYERDGEILATGSK 595
Query: 533 DGAVY 537
D V+
Sbjct: 596 DQTVF 600
Score = 29.6 bits (65), Expect = 9.9
Identities = 16/65 (24%), Positives = 30/65 (46%)
Query: 477 CSFSNGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAV 536
C NG +N N + + + + + G I+SI + DD L++ G DG +
Sbjct: 823 CGMKNGAIRVYVLNQNDPSLTSLVDYWHFNMHDNNYGCIKSIANSFDDRFLVTAGADGNI 882
Query: 537 YEWNL 541
+ +N+
Sbjct: 883 FVFNI 887
>gi|223005862 echinoderm microtubule associated protein like 6 [Homo
sapiens]
Length = 1958
Score = 70.1 bits (170), Expect = 7e-12
Identities = 138/679 (20%), Positives = 264/679 (38%), Gaps = 123/679 (18%)
Query: 11 VFGLRSHVANNIFYFD--EQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPN 68
V+G R H N Y+ ++++ F +G V YN + QKF G + +++L++ P+
Sbjct: 16 VYGYRGHQCRNNLYYTAGKEVVYFVAGVGVV-YNTREHSQKFFLGH--NDDIISLALHPD 72
Query: 69 RRYLAISETVQEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSKYLLAQTSP 128
+ +A + V ++P I I++ ++ + V D +AF D + L +
Sbjct: 73 KTLVATGQ-VGKEPYICIWDSYNV----QTVSLLKDVHTHGVACLAFDSDGQRLASVGLD 127
Query: 129 PESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEGTL- 187
++ + W W K K++A ++ ++ +S+ P +V G K L
Sbjct: 128 AKNTVCIWDWRKGKLLASAT--GHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLCGNALT 185
Query: 188 -KQTSFQR-GEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGSKS 245
K+ F + G+ Q L +D G G ++++ K
Sbjct: 186 AKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVW--------------------KG 225
Query: 246 LDVIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAGPGRVL 305
L++++ + +HS +F++ A +GFA G +
Sbjct: 226 LNLVRTIQG---------------------AHSA----GIFSMYACEEGFATGGRDGCIR 260
Query: 306 LFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQLYSI 365
L++ DF ++ +D + + + +C+ + L+A T ++++ +
Sbjct: 261 LWDT----DFKPITK-----IDLRETEQGYKGLS-IRSVCWKA--DRLLAGTQDSEIFEV 308
Query: 366 TMSLTEISKGEPAHFEYLMYPLH-SAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLE 424
+ + +P L+ H + LA +KPL T S DRS+RLW+ + L
Sbjct: 309 IVR----ERDKPM----LILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI 360
Query: 425 LFKEYQEEAYSISLHPSGHFIVVGFAD----KLRLMNLL-IDDIRSFKEYSVRGCGECSF 479
+E S++ P G + +G D LR+ ++ + I+ KE E F
Sbjct: 361 ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEV----IHEMKF 416
Query: 480 S-NGGHLFAAVNGNVIHVYTTTS-LENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVY 537
S +G +L N + VY + I I I W+ D L + G
Sbjct: 417 SPDGSYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERL 476
Query: 538 EWNLSTGK----RETECVLKSCSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAF 593
+ + +GK +E + S+ CV P+ I+ ++ T +I++
Sbjct: 477 FYRMPSGKPLTSKEEIKGIPWASWTCVK-GPEVSGIWPKYTEVT-----------DINSV 524
Query: 594 DVTYTAIVISHSGRMMFVGTSVGTIRAMKYP-LPLQKEFNEYQAHAGPITKV------SR 646
D Y + V + G G ++ K+P L +F +Y H+ +T V
Sbjct: 525 DANYNSSV-------LVSGDDFGLVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQW 577
Query: 647 TLSPGTQSHTCLLRALFIP 665
LS G H+ + + FIP
Sbjct: 578 VLSTGGADHS-VFQWRFIP 595
Score = 70.1 bits (170), Expect = 7e-12
Identities = 133/645 (20%), Positives = 253/645 (39%), Gaps = 112/645 (17%)
Query: 20 NNIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPNRRYLAISETVQ 79
NN+FY +++ V YN Q Q+ G + +L+L+I P + Y+A + V
Sbjct: 692 NNLFYTQAGEVVYHIAAVAVVYNRQQHSQRLYLGHDDD--ILSLTIHPVKDYVATGQ-VG 748
Query: 80 EKPAITIYELSSIPCRKRKVLNNFDFQVQKFI-SMAFSPDSKYLLAQTSPPESNLVYWLW 138
AI +++ ++ C L+ Q Q+ + ++ FS D K L++ ++V+W W
Sbjct: 749 RDAAIHVWDTQTLKC-----LSLLKGQHQRGVCALDFSADGKCLVSVGLDDFHSIVFWDW 803
Query: 139 EKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEG--TLKQTSF-QRG 195
+K + +A R + ++ V +P ++ G K + A G T K+ +F G
Sbjct: 804 KKGEKIATTR--GHKDKIFVVKCNPHHVDKLVTVGIKHIKFWQQAGGGFTSKRGTFGSVG 861
Query: 196 EPQNYLAHTW-VADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGSKSLDVIQESES 254
+ + + ++ +D + G TG +F+ W+ +++K
Sbjct: 862 KLETMMCVSYGRMEDLVFSGAATGDIFI-------WKDILLLK----------------- 897
Query: 255 LIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAGPGRVLLFEKMEEK- 313
+H VFA+ A KGF G V L++ M E+
Sbjct: 898 ------------------TVKAHD----GPVFAMYALDKGFVTGGKDGIVELWDDMFERC 935
Query: 314 -DFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQLYSITMSLTEI 372
Y R + S L L +PS + + + + EI
Sbjct: 936 LKTYAIKRS------------ALSTSSKGLLLEDNPSIRAITLGHGHILVGTKNGEILEI 983
Query: 373 SKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYET-NTLELFKEYQE 431
K P L+ + GLA P+ AT S D+++R+W + + ++ ++
Sbjct: 984 DKSGP--MTLLVQGHMEGEVWGLAAHPLLPICATVSDDKTLRIWELSAQHRMLAVRKLKK 1041
Query: 432 EAYSISLHPSGHFIVVGFAD-KLRLMNL-LIDDIRSFKEYSVRGCGECSFS--NGGHLFA 487
+ P G + VG D ++N ++D+ SF + + FS G +L
Sbjct: 1042 GGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSF-HHRKEMISDIKFSKDTGKYLAV 1100
Query: 488 AVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKL-ISGGTDGAVYEWNLSTGKR 546
A + N + +Y + + + KG + I I W++ L ++ G ++ + GKR
Sbjct: 1101 ASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLLQVNSGAREQLF-FEAPRGKR 1159
Query: 547 ------ETECVLKSCSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAFDVTYTAI 600
E E ++ ++ CV + P + I+ SD T +++A +T
Sbjct: 1160 HIIRPSEIE-KIEWDTWTCV-LGPTCEGIWPAHSDIT-----------DVNAASLTKDCS 1206
Query: 601 VISHSGRMMFVGTSVGTIRAMKYPLPLQ-KEFNEYQAHAGPITKV 644
+++ G G ++ YP+ Q F +Y H+ +T V
Sbjct: 1207 LLA-------TGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNV 1244
Score = 40.4 bits (93), Expect = 0.006
Identities = 48/222 (21%), Positives = 88/222 (39%), Gaps = 13/222 (5%)
Query: 10 HVFGLRSH-VANNIFYFDEQI-IIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISP 67
HVFG R NN+ Y ++ IIF + + N+ Q F E + +L L+++
Sbjct: 1367 HVFGYRGFDCRNNLHYLNDGADIIFHTAAAGIVQNLSTGSQSFY--LEHTDDILCLTVNQ 1424
Query: 68 NRRYLAISETVQEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSKYLLAQTS 127
+ +Y + T Q +I+ ++ +L F + +I+ FS K L++
Sbjct: 1425 HPKYRNVVATSQIGTTPSIHIWDAMTKHTLSMLRCFHSKGVNYIN--FSATGKLLVSVGV 1482
Query: 128 PPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEGTL 187
PE + W W Q+ + ++ V F P +TQ G K A L
Sbjct: 1483 DPEHTITVWRW--QEGAKVASRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSAL 1540
Query: 188 KQT-----SFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFE 224
S + Q L+ + A++ G G +++++
Sbjct: 1541 LYKKGVIGSLGAAKMQTMLSVAFGANNLTFTGAINGDVYVWK 1582
Score = 31.6 bits (70), Expect = 2.6
Identities = 43/198 (21%), Positives = 74/198 (37%), Gaps = 47/198 (23%)
Query: 383 LMYPLHSAPITGLATCIRKPLIATCSLDR------SIRLWNYETNTLELFKEYQEEAYSI 436
L+ H+ P+ + T +R LI T +R +++LW+ E F+ +
Sbjct: 1589 LVAKAHTGPVFTMYTTLRDGLIVTGGKERPTKEGGAVKLWDQEMKRCRAFQLETGQ---- 1644
Query: 437 SLHPSGHFIVVGFADKLRLMNLLIDDIRSFKEYSVRGCGECSFSNGGHLFAAVNGNVIHV 496
L++ +RS RG G+ L +G +I V
Sbjct: 1645 ----------------------LVECVRSV----CRGKGKI-------LVGTKDGEIIEV 1671
Query: 497 YTTTSLENISSLKGHT-GKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSC 555
+ NI + GH G+I + + IS DG W+L+ K + L
Sbjct: 1672 GEKNAASNIL-IDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHA 1730
Query: 556 SYNCVTVSPDAKIIFAVG 573
+ C SPD +++ A+G
Sbjct: 1731 A-RCAAYSPDGEMV-AIG 1746
>gi|223029510 echinoderm microtubule associated protein like 4
isoform b [Homo sapiens]
Length = 923
Score = 70.1 bits (170), Expect = 7e-12
Identities = 113/534 (21%), Positives = 199/534 (37%), Gaps = 94/534 (17%)
Query: 130 ESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEGTL-- 187
E L W W+K+ A I T N V V F P D + G ++ +L
Sbjct: 330 EHMLTVWDWQKKAKGA--EIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTR 387
Query: 188 KQTSFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGSKSLD 247
KQ F + E ++ + V+ D+G + L S +T++ EPT G
Sbjct: 388 KQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWS-----KTTV---EPTPGKGPKG 439
Query: 248 VIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAG--PGRVL 305
V Q S+ + +H VF + G + G +++
Sbjct: 440 VYQISKQI-------------------KAHDG----SVFTLCQMRNGMLLTGGGKDRKII 476
Query: 306 LFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQLYSI 365
L++ D E REI +P D+ + + + TS+N +
Sbjct: 477 LWDH----DLNPE-REIEVP-----------DQYGTIRAVAEGKADQFLVGTSRNFILRG 520
Query: 366 TMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLEL 425
T + F+ + H+ + GLAT K L+ TC+ DR + LWN + LE
Sbjct: 521 TFN---------DGFQIEVQG-HTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEW 570
Query: 426 FKEYQEEAYSISLHPSGHFIVVG-FADKLRLMNLLIDDIRSFKEYSVRGCGECSFS-NGG 483
+ E + HPSG + +G + + +++ D+ S +S +G
Sbjct: 571 TRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGT 630
Query: 484 HLFAAVNGNVIHVYTTT----SLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEW 539
L + N I++Y + GH+ I + W+ D+ ++S D + W
Sbjct: 631 FLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYW 690
Query: 540 NLSTG----KRETECV-LKSCSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAFD 594
++ G + ++C + +Y CV + ++ GSD T
Sbjct: 691 DIPNGCKLIRNRSDCKDIDWTTYTCV-LGFQVFGVWPEGSDGT----------------- 732
Query: 595 VTYTAIVISHSGRMMFVGTSVGTIRAMKYPLPLQK-EFNEYQAHAGPITKVSRT 647
A+V SH+ +++ V + +YP K ++Y AH+ +T VS T
Sbjct: 733 -DINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFT 785
>gi|19923497 echinoderm microtubule associated protein like 4
isoform a [Homo sapiens]
Length = 981
Score = 70.1 bits (170), Expect = 7e-12
Identities = 113/534 (21%), Positives = 199/534 (37%), Gaps = 94/534 (17%)
Query: 130 ESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEGTL-- 187
E L W W+K+ A I T N V V F P D + G ++ +L
Sbjct: 388 EHMLTVWDWQKKAKGA--EIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWTWSGNSLTR 445
Query: 188 KQTSFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGSKSLD 247
KQ F + E ++ + V+ D+G + L S +T++ EPT G
Sbjct: 446 KQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWS-----KTTV---EPTPGKGPKG 497
Query: 248 VIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAG--PGRVL 305
V Q S+ + +H VF + G + G +++
Sbjct: 498 VYQISKQI-------------------KAHDG----SVFTLCQMRNGMLLTGGGKDRKII 534
Query: 306 LFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQLYSI 365
L++ D E REI +P D+ + + + TS+N +
Sbjct: 535 LWDH----DLNPE-REIEVP-----------DQYGTIRAVAEGKADQFLVGTSRNFILRG 578
Query: 366 TMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLEL 425
T + F+ + H+ + GLAT K L+ TC+ DR + LWN + LE
Sbjct: 579 TFN---------DGFQIEVQG-HTDELWGLATHPFKDLLLTCAQDRQVCLWNSMEHRLEW 628
Query: 426 FKEYQEEAYSISLHPSGHFIVVG-FADKLRLMNLLIDDIRSFKEYSVRGCGECSFS-NGG 483
+ E + HPSG + +G + + +++ D+ S +S +G
Sbjct: 629 TRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGT 688
Query: 484 HLFAAVNGNVIHVYTTT----SLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEW 539
L + N I++Y + GH+ I + W+ D+ ++S D + W
Sbjct: 689 FLAVGSHDNFIYLYVVSENGRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYW 748
Query: 540 NLSTG----KRETECV-LKSCSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAFD 594
++ G + ++C + +Y CV + ++ GSD T
Sbjct: 749 DIPNGCKLIRNRSDCKDIDWTTYTCV-LGFQVFGVWPEGSDGT----------------- 790
Query: 595 VTYTAIVISHSGRMMFVGTSVGTIRAMKYPLPLQK-EFNEYQAHAGPITKVSRT 647
A+V SH+ +++ V + +YP K ++Y AH+ +T VS T
Sbjct: 791 -DINALVRSHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFT 843
>gi|34485720 echinoderm microtubule associated protein like 5 [Homo
sapiens]
Length = 1977
Score = 64.7 bits (156), Expect = 3e-10
Identities = 134/655 (20%), Positives = 246/655 (37%), Gaps = 107/655 (16%)
Query: 11 VFGLRSH-VANNIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPNR 69
V G R + +N+FY I++ V YN Q Q+F G + +L L+I P +
Sbjct: 682 VHGYRGYDCRSNLFYTQIGEIVYHVAAVGVIYNRQQNTQRFYLGHDDD--ILCLTIHPLK 739
Query: 70 RYLAISETVQEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMA-FSPDSKYLLAQTSP 128
Y+A + V P+I I++ +I K L+ Q +S FS D K L +
Sbjct: 740 DYVATGQ-VGRDPSIHIWDTETI-----KPLSILKGHHQYGVSAVDFSADGKRLASVGID 793
Query: 129 PESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEGTLK 188
+V W W+K + ++I R + ++ V +P ++ G K R A G L
Sbjct: 794 DSHTVVLWDWKKGEKLSIAR--GSKDKIFVVKMNPYVPDKLITAGIKHMKFWRKAGGGLI 851
Query: 189 QT-----SFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGS 243
+ + + + W ++ GT TG + + W +VK
Sbjct: 852 GRKGYIGTLGKNDTMMCAVYGWT-EEMAFSGTSTGDVCI-------WRDIFLVK------ 897
Query: 244 KSLDVIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAGPGR 303
+H VF++ A KGF G
Sbjct: 898 -----------------------------TVKAHDG----PVFSMHALEKGFVTGGKDGI 924
Query: 304 VLLFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQLY 363
V L++ E+ + + R + P S D + + ++ T ++
Sbjct: 925 VALWDDSFERCLKTYAIK-RAALAPGSKGLLLEDNPSIRAISLGHGH--ILVGTKNGEIL 981
Query: 364 SITMS--LTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYE-T 420
+ S +T + +G H E + GLAT P+ AT S D+++R+W+ +
Sbjct: 982 EVDKSGPITLLVQG---HME--------GEVWGLATHPYLPICATVSDDKTLRIWDLSPS 1030
Query: 421 NTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNL--LIDDIRSFKEYSVRGCGECS 478
+ + ++ ++ P G + VG D LM ++D+ SF + +
Sbjct: 1031 HCMLAVRKLKKGGRCCCFSPDGKALAVGLNDGSFLMANADTLEDLVSF-HHRKDMISDIR 1089
Query: 479 FS--NGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKL-ISGGTDGA 535
FS +G +L A + + I +Y S + + KG T I I W+ L ++ G
Sbjct: 1090 FSPGSGKYLAVASHDSFIDIYNVMSSKRVGICKGATSYITHIDWDIRGKLLQVNTGAKEQ 1149
Query: 536 VYEWNLSTGKRETECVLKSCSYNCVTVSPDAKI--IFAVGSDHTLKEIADSLILREISAF 593
++ + GK++T + S + + + + G + E+ D
Sbjct: 1150 LF-FEAPRGKKQT---IPSVEVEKIAWASWTSVLGLCCEGIWPVIGEVTD---------- 1195
Query: 594 DVTYTAIVISHSGRMMFVGTSVGTIRAMKYPLPLQ-KEFNEYQAHAGPITKVSRT 647
TA ++ ++ G +G ++ +YP + +F Y AH+ +T V T
Sbjct: 1196 ---VTASCLTSDKMVLATGDDLGFVKLFRYPTKGKFGKFKRYVAHSTHVTNVRWT 1247
Score = 53.1 bits (126), Expect = 8e-07
Identities = 125/652 (19%), Positives = 249/652 (38%), Gaps = 116/652 (17%)
Query: 11 VFGLRSHVANNIFYFD--EQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPN 68
V+G R H N Y+ ++I+ F +G V Y+ + QKF G S +++L++ P
Sbjct: 16 VYGYRGHQCRNNLYYTAAKEIVYFVAGVGVV-YSPREHRQKFYRGH--SDDIISLALHPE 72
Query: 69 RRYLAISETVQEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSKYLLAQTSP 128
R +A + V ++P I I++ S + VL D +AF D + L++
Sbjct: 73 RVLVATGQ-VGKEPYICIWD--SYTVQTISVLK--DVHTHGIACLAFDLDGQRLVSVGLD 127
Query: 129 PESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEGTL- 187
++ + W W++ K++++ T ++ +S+ ++ G K L
Sbjct: 128 SKNAVCVWDWKRGKMLSMAPGHTDR--IFDISWDLYQPNKLVSCGVKHIKFWSLCGNALT 185
Query: 188 -KQTSFQR-GEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGSKS 245
K+ F + G+ Q L D+ G G +++++ G
Sbjct: 186 PKRGVFGKTGDLQTILCLACARDELTYSGALNGDIYVWK-----------------GINL 228
Query: 246 LDVIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAGPGRVL 305
+ IQ + + +F++ A +GFA G +
Sbjct: 229 IRTIQGAHAA----------------------------GIFSMNACEEGFATGGRDGCIR 260
Query: 306 LFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQLYSI 365
L++ + I + +D + D V +C+ ++ T ++++ I
Sbjct: 261 LWDLT--------FKPITV-IDLRETDQGYKGLS-VRSVCWRGDH--ILVGTQDSEIFEI 308
Query: 366 TMSLTEISKGEPAHFEYLMYPLH-SAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLE 424
+ + +P +L+ H + LA KPL T S DRS+R+W+ + L
Sbjct: 309 VVQ----ERNKP----FLIMQGHCEGELWALAVHPTKPLAVTGSDDRSVRIWSLVDHALI 360
Query: 425 LFKEYQEEAYSISLHPSGHFIVVGFAD----KLRLMNLL-IDDIRSFKEYSVRGCGECSF 479
+E +++ G + +G D LR+ ++ + I+ KE E +
Sbjct: 361 ARCNMEEPIRCAAVNADGIHLALGMKDGSFTVLRVRDMTEVVHIKDRKE----AIHELKY 416
Query: 480 S-NGGHLFAAVNGNVIHVY-TTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVY 537
S +G +L N + + +Y + + G I + W++D L + +G
Sbjct: 417 SPDGTYLAVGCNDSSVDIYGVAQRYKKVGECLGSLSFITHLDWSSDSRYLQTNDGNGKRL 476
Query: 538 EWNLSTGKRETECV----LKSCSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAF 593
+ + GK T + S+ CV+ + I+ SD + +I++
Sbjct: 477 FYRMPGGKEVTSTEEIKGVHWASWTCVS-GLEVNGIWPKYSD-----------INDINSV 524
Query: 594 DVTYTAIVISHSGRMMFVGTSVGTIRAMKYP-LPLQKEFNEYQAHAGPITKV 644
D Y G+++ G I+ +YP L +F +Y H+ +T V
Sbjct: 525 DGNYI-------GQVLVTADDYGIIKLFRYPCLRKGAKFRKYIGHSAHVTNV 569
Score = 41.6 bits (96), Expect = 0.003
Identities = 54/236 (22%), Positives = 94/236 (39%), Gaps = 36/236 (15%)
Query: 11 VFGLRSH-VANNIFYF-DEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPN 68
+FG R NN+ Y D II+ + + + +NV Q F E + +L L+++ +
Sbjct: 1376 IFGYRGRDCRNNVHYLNDGDDIIYHTASVGILHNVATGSQSFY--QEHNDDILCLTVNQH 1433
Query: 69 RRYLAISETVQ---------EKPAITIYE------LSSIPCRKRKVLNNFDFQVQKFISM 113
+++ I T Q P+I I++ LS + C K + S+
Sbjct: 1434 PKFINIVATGQVGDSADMSATAPSIHIWDAMNKQTLSILRCYHSKGV----------CSV 1483
Query: 114 AFSPDSKYLLAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTG 173
+FS K LL+ PE + W W Q+ I N ++ F P +TQ G
Sbjct: 1484 SFSATGKLLLSVGLDPEHTITIWRW--QEGAKIASRAGHNQRIFVAEFRPDSDTQFVSVG 1541
Query: 174 NGMFKLLRFAEGTLKQ-----TSFQRGEPQNYLAHTWVADDKIVVGTDTGKLFLFE 224
K A L ++ + Q LA + A++ GT +G + +++
Sbjct: 1542 VKHVKFWTLAGRALLSKKGLLSTLEDARMQTMLAIAFGANNLTFTGTISGDVCVWK 1597
Score = 38.1 bits (87), Expect = 0.028
Identities = 57/266 (21%), Positives = 106/266 (39%), Gaps = 27/266 (10%)
Query: 391 PITGLATCIRKPLIATCSLDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVVGFA 450
PI GLAT + + + D ++RLW+ + A ++ P G + +G
Sbjct: 1704 PIWGLATHPSRDFFLSAAEDGTVRLWDIADKKMLNKVNLGHAARTVCYSPEGDMVAIGMK 1763
Query: 451 DKLRLMNLLIDDIRSFKEYSVRGCG--ECSFS-NGGHLFAAVNGNVIHVYTTT---SLEN 504
+ + LL+ ++ + + R C + FS + +L + N + Y T +L
Sbjct: 1764 NG-EFIILLVSSLKIWGKKRDRRCAIHDIRFSPDSRYLAVGSSENSVDFYDLTLGPTLNR 1822
Query: 505 ISSLKGHTGKIRSIVWNADDSKL--ISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTV 562
IS K + + ++AD S L SG VYE + +GK ++ + + +T
Sbjct: 1823 ISYCKDIPSFVIQMDFSADSSYLQVSSGCYKRHVYE--VPSGKH----LMDHAAIDRITW 1876
Query: 563 SPDAKIIFAVGSDHTLKEIADSLILREISAFDVTYTAIVISHSGRMMFVGTSVGTIRAMK 622
+ I+ D L + R DV + SHSG + G G ++
Sbjct: 1877 ATWTSIL----GDEVL-----GIWSRHAEKADVNCACV--SHSGISLVTGDDFGMVKLFD 1925
Query: 623 YPLPLQ-KEFNEYQAHAGPITKVSRT 647
+P P + + + H+ +T + T
Sbjct: 1926 FPCPEKFAKHKRFLGHSPHVTNIRFT 1951
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 63.5 bits (153), Expect = 6e-10
Identities = 80/350 (22%), Positives = 141/350 (40%), Gaps = 50/350 (14%)
Query: 351 ETLVASTSKNQLYSITMSLTEISKGEPAHFEYLMYPL--HSAPITGLATCIRKPLIATCS 408
E L+ ++ Q+ + L E H YL L H P+T +A T S
Sbjct: 52 EPLLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGS 111
Query: 409 LDRSIRLWNY----ETNTLELFKEYQEEAYSISLH-PSGHFIVVGFADKLRLMNLLIDDI 463
DR+ +LW+ E NTLE ++ Y+I+ + P G I G DK
Sbjct: 112 YDRTCKLWDTASGEELNTLE---GHRNVVYAIAFNNPYGDKIATGSFDK----------- 157
Query: 464 RSFKEYSVRGCGECSFSNGGHLFAAV------NGNVI---HVYTTTSL------ENISSL 508
+ K +SV G+C + GH V ++ + TT L E + +L
Sbjct: 158 -TCKLWSVE-TGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTL 215
Query: 509 KGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSPDAKI 568
+GH+ +I S+ +N ++I+G D V W+ TG++ + + + + D +
Sbjct: 216 RGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSL 275
Query: 569 IFAVGSDHTLK--EIADSLILREISAFDVTYTAIVISHSGRMMFVGTSVGTIRAMKYPLP 626
I D T K + + + ++ D ++G+++ ++ GT R +
Sbjct: 276 ILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARI--FSAA 333
Query: 627 LQKEFNEYQAHAGPITKVS-----RTLSPGTQSHTCLLRALFIPSTSQCL 671
+K + + H G I+K+S L G+ T ++ T QCL
Sbjct: 334 TRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTA---RIWDAQTGQCL 380
Score = 35.8 bits (81), Expect = 0.14
Identities = 53/247 (21%), Positives = 89/247 (36%), Gaps = 58/247 (23%)
Query: 340 DVLCLCFSPSEETLVASTSKNQLYSITMSLTEISKGEPAHFEYLMYPL--HSAPITGLAT 397
+++CL F+P + TLVA+ S + T L +I GE +Y L HSA I L+
Sbjct: 179 EIVCLSFNP-QSTLVATGSMDT----TAKLWDIQNGEE------VYTLRGHSAEIISLSF 227
Query: 398 CIRKPLIATCSLDRSIRLWNYETNT-LELFKEYQEEAYSISLHPSGHFIVVGFADKL--- 453
I T S D ++ +W+ +T + + + E S S + I+ G DK
Sbjct: 228 NTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKL 287
Query: 454 -----------------------------RLMNLLIDDIRSFKEYSVRGC---------- 474
+ D + R C
Sbjct: 288 WDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGE 347
Query: 475 -GECSFS-NGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGT 532
+ SF+ G HL + ++ + + + L+GHT +I S +N + +I+G
Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSK 407
Query: 533 DGAVYEW 539
D W
Sbjct: 408 DNTCRIW 414
>gi|6912356 echinoderm microtubule associated protein like 2 [Homo
sapiens]
Length = 649
Score = 63.5 bits (153), Expect = 6e-10
Identities = 56/266 (21%), Positives = 105/266 (39%), Gaps = 24/266 (9%)
Query: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVV 447
H + GLAT + TC D+ + LW+ +++ + ++ A S HPSG + V
Sbjct: 376 HVEELWGLATHPSRAQFVTCGQDKLVHLWSSDSHQPLWSRIIEDPARSAGFHPSGSVLAV 435
Query: 448 G-FADKLRLMNLLIDDIRSFKEYSVRGCGECSFS-NGGHLFAAVNGNVIHVYTT----TS 501
G + L++ D+ + SFS +G +L + N+++VYT
Sbjct: 436 GTVTGRWLLLDTETHDLVAIHTDGNEQISVVSFSPDGAYLAVGSHDNLVYVYTVDQGGRK 495
Query: 502 LENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETEC-VLKSCSYNCV 560
+ + GH+ I + W D S ++ D + W+ +T K+ T +++ +
Sbjct: 496 VSRLGKCSGHSSFITHLDWAQDSSCFVTNSGDYEILYWDPATCKQITSADAVRNMEWATA 555
Query: 561 TVSPDAKIIFAVGSDHTLKEIADSLILREISAFDVTYTAIVISHSGRMMFVGTSVGTIRA 620
T + G E AD A+ SH G+++ G +
Sbjct: 556 T------CVLGFGVFGIWSEGADG----------TDINAVARSHDGKLLASADDFGKVHL 599
Query: 621 MKYPLPLQKEF-NEYQAHAGPITKVS 645
YP + ++Y H+ +T V+
Sbjct: 600 FSYPCCQPRALSHKYGGHSSHVTNVA 625
Score = 42.0 bits (97), Expect = 0.002
Identities = 52/236 (22%), Positives = 97/236 (41%), Gaps = 16/236 (6%)
Query: 11 VFGLRSHVAN-NIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPNR 69
V+G R N++ I++ + V Y+V+++ Q+ G + + L+I P+
Sbjct: 60 VYGYRGRDCRANLYLLPTGEIVYFVASVAVLYSVEEQRQRHYLGH--NDDIKCLAIHPDM 117
Query: 70 RYLA---ISETVQE----KPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSKYL 122
+A ++ T +E P + I++ S+ L FD V + + S L
Sbjct: 118 VTIATGQVAGTTKEGKPLPPHVRIWDSVSLSTLHVLGLGVFDRAVC-CVGFSKSNGGNLL 176
Query: 123 LAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRF 182
A + L W W K+ +V + N V +F P D T + G
Sbjct: 177 CAVDESNDHMLSVWDWAKET--KVVDVKCSNEAVLVATFHPTDPTVLITCGKSHIYFWTL 234
Query: 183 AEGTL--KQTSFQRGE-PQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIM 235
G+L +Q F++ E P+ L T++ +V G G L+++ G R +++
Sbjct: 235 EGGSLSKRQGLFEKHEKPKYVLCVTFLEGGDVVTGDSGGNLYVWGKGGNRITQAVL 290
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 59.3 bits (142), Expect = 1e-08
Identities = 64/266 (24%), Positives = 108/266 (40%), Gaps = 13/266 (4%)
Query: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLEL-FKEYQEEAYSISLHPSGHFIV 446
H A IT L +AT S D + LWN++ + + +++ S+ P G+ +
Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLA 76
Query: 447 VGFADKLRLMNLLIDDIR-SFKEYSVRGCGECSF---SNGGHLFAAVNGNVIHVYTTTSL 502
D R + L I D R F E+ S ++G L A I V++
Sbjct: 77 SASRD--RTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQ 134
Query: 503 ENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSY-NCVT 561
+ SL HT +R ++ D ++S D + W+ +T K+ S + N V
Sbjct: 135 RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWD-TTNKQCVNNFSDSVGFANFVD 193
Query: 562 VSPDAKIIFAVGSDHTLK--EIADSLILREISAFDVTYTAIVISHSGRMMFVGTSVGTIR 619
+P I + GSD T+K ++ + +L+ I SG + +S GT++
Sbjct: 194 FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLK 253
Query: 620 AMKYPLPLQKEFNEYQAHAGPITKVS 645
+ L + Q H GP+ VS
Sbjct: 254 IL--DLLEGRLIYTLQGHTGPVFTVS 277
Score = 56.2 bits (134), Expect = 1e-07
Identities = 45/204 (22%), Positives = 80/204 (39%), Gaps = 3/204 (1%)
Query: 379 HFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYETN-TLELFKEYQEEAYSIS 437
H Y H +T + L+A+ S DR++RLW + FK + S+
Sbjct: 50 HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVD 109
Query: 438 LHPSGHFIVVGFADKLRLMNLLIDDIRSFKEYSVRGCGECS-FSNGGHLFAAVNGN-VIH 495
G F+ DK + + + Y C+ FS G L + + + I
Sbjct: 110 FSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIK 169
Query: 496 VYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSC 555
++ TT+ + +++ G + +N + + S G+D V W++ K + S
Sbjct: 170 IWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSG 229
Query: 556 SYNCVTVSPDAKIIFAVGSDHTLK 579
NC++ P + SD TLK
Sbjct: 230 GVNCISFHPSGNYLITASSDGTLK 253
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/142 (22%), Positives = 66/142 (46%), Gaps = 7/142 (4%)
Query: 403 LIATCSLDRSIRLWNYETNTLELFKEYQEE---AYSISLHPSGHFIVVGFADK-LRLMNL 458
LI +CS D++I++W +T + + + A + +PSG I +D+ +++ ++
Sbjct: 158 LIVSCSEDKTIKIW--DTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215
Query: 459 LIDDIRSFKEYSVRGCGECSFS-NGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRS 517
++ + + G SF +G +L A + + + I +L+GHTG + +
Sbjct: 216 RVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFT 275
Query: 518 IVWNADDSKLISGGTDGAVYEW 539
+ ++ SGG D V W
Sbjct: 276 VSFSKGGELFASGGADTQVLLW 297
>gi|110227615 echinoderm microtubule associated protein like 3 [Homo
sapiens]
Length = 896
Score = 55.5 bits (132), Expect = 2e-07
Identities = 60/274 (21%), Positives = 108/274 (39%), Gaps = 35/274 (12%)
Query: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVV 447
H+ + GL T + TC DR + LW+ E++ L + +E HPSG + V
Sbjct: 596 HTDELWGLCTHPSQNRFLTCGHDRQLCLWDGESHALAWSIDLKETGLCADFHPSGAVVAV 655
Query: 448 GFADKLRLMNLLIDDIRSFKEYSVRGCGECSF----SNGGHLFAAVNGNVIHVYTTTS-- 501
G L +L + R + G + S +G +L + NVI++Y+ +S
Sbjct: 656 GLNTGRWL--VLDTETREIVSDVIDGNEQLSVVRYSPDGLYLAIGSHDNVIYIYSVSSDG 713
Query: 502 --LENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKS----- 554
GH+ I + W+ D + ++S D + W+++ G ++ + +S
Sbjct: 714 AKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKQLKNRYESRDREW 773
Query: 555 CSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAFDVTYTAIVISHSGRMMFVGTS 614
+Y CV + ++ GSD T ++ SH+ R++ V
Sbjct: 774 ATYTCV-LGFHVYGVWPDGSDGT------------------DINSLCRSHNERVVAVADD 814
Query: 615 VGTIRAMKYPLPLQKEFNE-YQAHAGPITKVSRT 647
+ +YP K + Y H +T V T
Sbjct: 815 FCKVHLFQYPCARAKAPSRMYGGHGSHVTSVRFT 848
Score = 30.8 bits (68), Expect = 4.4
Identities = 12/33 (36%), Positives = 21/33 (63%), Gaps = 1/33 (3%)
Query: 510 GHTGKIRSIVWNADDSKLIS-GGTDGAVYEWNL 541
GH + S+ + DDS L+S GG D ++++W +
Sbjct: 837 GHGSHVTSVRFTHDDSHLVSLGGKDASIFQWRV 869
Score = 29.6 bits (65), Expect = 9.9
Identities = 19/94 (20%), Positives = 41/94 (43%), Gaps = 10/94 (10%)
Query: 137 LWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEG---------TL 187
+W+ + M + I + N+ V V F+P+D++ + +G ++ G T
Sbjct: 389 VWDCSRGMKLAEIKSTNDSVLAVGFNPRDSSCIVTSGKSHVHFWNWSGGVGVPGNGTLTR 448
Query: 188 KQTSFQRGEPQNYL-AHTWVADDKIVVGTDTGKL 220
KQ F + + ++ ++ D I+ G G +
Sbjct: 449 KQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNI 482
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 55.5 bits (132), Expect = 2e-07
Identities = 43/198 (21%), Positives = 86/198 (43%), Gaps = 41/198 (20%)
Query: 383 LMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYE-TNTLELFKEYQEEAYSISLHPS 441
++Y H+ P+ L A+ S DR+ RLW+++ T L ++ + + + HP+
Sbjct: 378 VLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPN 437
Query: 442 GHFIVVGFADKLRLMNLLIDDIRSFKEYSVRGCGECSFSNGGHLFAAVNGNVIHVYTTTS 501
+++ G DK +VR L++A GN + ++T
Sbjct: 438 SNYLATGSTDK-----------------TVR------------LWSAQQGNSVRLFT--- 465
Query: 502 LENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVT 561
GH G + S+ ++ + L S G D + W+L++G E + + +T
Sbjct: 466 --------GHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLT 517
Query: 562 VSPDAKIIFAVGSDHTLK 579
SPD+ +I + D++++
Sbjct: 518 FSPDSGLIASASMDNSVR 535
Score = 30.0 bits (66), Expect = 7.6
Identities = 24/98 (24%), Positives = 38/98 (38%), Gaps = 6/98 (6%)
Query: 115 FSPDSKYLLAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGN 174
F P+S YL ++ L W Q+ ++ PV ++FSP +
Sbjct: 434 FHPNSNYLATGSTDKTVRL----WSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGED 489
Query: 175 GMFKLLRFAEGTLKQTSFQRGEPQNYLAHTWVADDKIV 212
KL A GTL + RG N + T+ D ++
Sbjct: 490 QRLKLWDLASGTLYKE--LRGHTDNITSLTFSPDSGLI 525
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 53.9 bits (128), Expect = 5e-07
Identities = 47/210 (22%), Positives = 89/210 (42%), Gaps = 33/210 (15%)
Query: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWNYETNT-LELFKEYQEEAYSISLHPSGHFIV 446
HS P+ G + + + + S D ++RLW+ +T T L +K + + P G++ V
Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFV 601
Query: 447 VGFADK------------LRLMNLLIDDIRSFK-----EYSVRGCGECSFSNGGHLFAAV 489
G D+ LR+ + D+ + Y G + + L+ +
Sbjct: 602 SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTV----RLWDVL 657
Query: 490 NGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETE 549
NGN + ++T GH G I S+ ++ + L +G TDG V W++ G E
Sbjct: 658 NGNCVRIFT-----------GHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGE 706
Query: 550 CVLKSCSYNCVTVSPDAKIIFAVGSDHTLK 579
+ + + S D +I+ + D+T++
Sbjct: 707 LKGHTDTVCSLRFSRDGEILASGSMDNTVR 736
Score = 42.4 bits (98), Expect = 0.001
Identities = 37/136 (27%), Positives = 63/136 (46%), Gaps = 7/136 (5%)
Query: 410 DRSIRLWNYET-NTLELFKEYQEEAYSISLHPSGHFIVVGFADK-LRLMNLLIDD-IRSF 466
DR RLW + L +F + + HP+ +++ G AD+ +RL ++L + +R F
Sbjct: 606 DRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 665
Query: 467 KEYSVRGCGECSFSNGGHLFA--AVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADD 524
+ +FS G A A +G V+ ++ + LKGHT + S+ ++ D
Sbjct: 666 TGHK-GPIHSLTFSPNGRFLATGATDGRVL-LWDIGHGLMVGELKGHTDTVCSLRFSRDG 723
Query: 525 SKLISGGTDGAVYEWN 540
L SG D V W+
Sbjct: 724 EILASGSMDNTVRLWD 739
Score = 31.2 bits (69), Expect = 3.4
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 4/50 (8%)
Query: 114 AFSPDSKYLLAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSP 163
+FSPD YLL+ + E V LW Q +V N PV+ FSP
Sbjct: 550 SFSPDRNYLLSSS---EDGTVR-LWSLQTFTCLVGYKGHNYPVWDTQFSP 595
Score = 29.6 bits (65), Expect = 9.9
Identities = 13/36 (36%), Positives = 20/36 (55%)
Query: 508 LKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLST 543
L GH+G + ++ D + L+S DG V W+L T
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQT 574
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 53.5 bits (127), Expect = 6e-07
Identities = 41/161 (25%), Positives = 75/161 (46%), Gaps = 11/161 (6%)
Query: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWNYET-NTLELFKEYQEEAYSISLHPSGHFIV 446
H++P+ + + LI S SIR+W+ E L ++ S+ HP G F+
Sbjct: 62 HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVA 121
Query: 447 VGFADKLRLMNLLIDDIRSFK-EYSVRGCGEC----SFS-NGGHLFAAVNGNVIHVYTTT 500
G D N+ + DIR + RG + FS +G L +A + + + ++ T
Sbjct: 122 SGSQDT----NIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLT 177
Query: 501 SLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNL 541
+ + +S GHTG + + ++ ++ L SG +D + W+L
Sbjct: 178 AGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218
Score = 37.7 bits (86), Expect = 0.036
Identities = 30/118 (25%), Positives = 54/118 (45%), Gaps = 10/118 (8%)
Query: 339 QDVLCLCFSPSEETLVASTSKNQLYSITMSLTEISKGEPAHFEYLMYPLHSAPITGLATC 398
Q V CL FSP + L ++ + T+ L +++ G+ +P H+ P+ +
Sbjct: 148 QAVRCLRFSPDGKWLASAADDH-----TVKLWDLTAGKMMS----EFPGHTGPVNVVEFH 198
Query: 399 IRKPLIATCSLDRSIRLWNYET-NTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRL 455
+ L+A+ S DR+IR W+ E + + S+ +P G + G D LR+
Sbjct: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRV 256
Score = 30.8 bits (68), Expect = 4.4
Identities = 26/107 (24%), Positives = 51/107 (47%), Gaps = 12/107 (11%)
Query: 57 SQGMLALSISPNRRYLAISETVQEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFS 116
SQ + L SP+ ++LA + + + +++L++ K+++ F + F
Sbjct: 147 SQAVRCLRFSPDGKWLA---SAADDHTVKLWDLTA-----GKMMSEFPGHTGPVNVVEFH 198
Query: 117 PDSKYLLAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSP 163
P+ +YLLA S S+ W+ +K + I+ + PV V F+P
Sbjct: 199 PN-EYLLASGS---SDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 53.5 bits (127), Expect = 6e-07
Identities = 45/187 (24%), Positives = 88/187 (47%), Gaps = 11/187 (5%)
Query: 404 IATCSLDRSIRLWNYETNT-LELFKEYQEEAYSISLHPSGHFIVVGFADK------LRLM 456
+A+ D+ + LW+ ++ L L +++ S P+ + + G D LR++
Sbjct: 120 LASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMV 179
Query: 457 NLLIDDIRSFKEYSVRGCGECSFSNGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIR 516
+ ++ + +S C +S G L + IH++ T+ + LKGH ++
Sbjct: 180 TPAVSH-QALEGHSANISCLC-YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVK 237
Query: 517 SIVWNADDSKLISGGTDGAVYEWNLSTGK-RETECVLKSCSYNCVTVSPDAKIIFAVGSD 575
SI ++ D+ L S G V W+ +TGK ET + ++ C +PD KI+ + +D
Sbjct: 238 SIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTC-AFTPDGKILVSGAAD 296
Query: 576 HTLKEIA 582
T ++I+
Sbjct: 297 QTRRQIS 303
Score = 44.7 bits (104), Expect = 3e-04
Identities = 21/70 (30%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 477 CSFSNGGHLFAAVNGN-VIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGA 535
C FS GHLFA+ + + + ++ + + LKGH + ++ ++ D +L SGG D
Sbjct: 69 CRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKR 128
Query: 536 VYEWNLSTGK 545
V W++ +G+
Sbjct: 129 VMLWDVQSGQ 138
Score = 38.1 bits (87), Expect = 0.028
Identities = 25/119 (21%), Positives = 48/119 (40%), Gaps = 2/119 (1%)
Query: 496 VYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSC 555
V T ++ + H G++ S ++ D L++G DG VY W +G+ +
Sbjct: 5 VPATLAVRRVKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTG 64
Query: 556 SYNCVTVSPDAKIIFAVGSDHTLK--EIADSLILREISAFDVTYTAIVISHSGRMMFVG 612
SPD + + D T++ ++A + LR + + + S R + G
Sbjct: 65 PVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG 123
Score = 30.8 bits (68), Expect = 4.4
Identities = 28/117 (23%), Positives = 49/117 (41%), Gaps = 5/117 (4%)
Query: 463 IRSFKEYSVRGCGECSFS----NGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRSI 518
+R K + G GE + S +G L ++ + T S + + L GHTG ++
Sbjct: 11 VRRVKFFGQHG-GEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFC 69
Query: 519 VWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSPDAKIIFAVGSD 575
++ D S D V W+++ K S V+ SPD++ + + G D
Sbjct: 70 RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWD 126
>gi|94681049 hypothetical protein LOC80217 [Homo sapiens]
Length = 1665
Score = 53.5 bits (127), Expect = 6e-07
Identities = 40/165 (24%), Positives = 79/165 (47%), Gaps = 9/165 (5%)
Query: 8 TLHVFGLRSHVANNIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISP 67
+L V ++ N+ + ++ I +P GN+ + N++ K + + S G++A +I
Sbjct: 18 SLSVRWVQGFPKQNVHFVNDNTICYPCGNYVIFINIETKKKTVLQCSNGIVGVMATNIP- 76
Query: 68 NRRYLAISETVQEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSKYLLAQTS 127
+A S+ + KP I +Y + R+ K+ N + + ++FS YL + +S
Sbjct: 77 -CEVVAFSDR-KLKPLIYVYSFPGL-TRRTKLKGNI---LLDYTLLSFSYCGTYLASYSS 130
Query: 128 PPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVT 172
PE L W WE ++ + V Q+SF+P + Q+C++
Sbjct: 131 LPEFELALWNWESSIILC--KKSQPGMDVNQMSFNPMNWRQLCLS 173
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 52.4 bits (124), Expect = 1e-06
Identities = 95/529 (17%), Positives = 187/529 (35%), Gaps = 75/529 (14%)
Query: 98 KVLNNFDFQVQKFISMAFSPDSKYLLAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVY 157
++++ +D ++ F+ S +LL T S+ LW+ + + N V
Sbjct: 690 ELVHTYDEHSEQVNCCHFTNSSHHLLLATG--SSDCFLKLWDLNQKECRNTMFGHTNSVN 747
Query: 158 QVSFSPQDNTQVCVTGNGMFKLLRFAEGT------LKQTSFQRGEPQNYL-----AHTWV 206
FSP D + +G KL +KQ +PQ + +W
Sbjct: 748 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 807
Query: 207 ADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGSKS------------LDVIQESES 254
AD ++ K+FLF+ TS ++ E G S L V+ S+
Sbjct: 808 ADGARIMVAAKNKIFLFDI-----HTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQY 862
Query: 255 LIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAGPGRVLLFE------ 308
+E S + A +S + F S+ + L+E
Sbjct: 863 CVELWNTDS------RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 916
Query: 309 ------KMEEKDFYRESREIRIPVDP---------QSNDPSQSDKQDVLCLCFSPSEETL 353
K E ++E+ + + VD ++ + V C C SP + +
Sbjct: 917 NSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYI 976
Query: 354 VASTSKNQLYSITMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSI 413
+ + + I + H + + + +A K LI++ S D I
Sbjct: 977 AFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTAD--------EKTLISS-SDDAEI 1027
Query: 414 RLWNYETNTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDIRSFKEYSVRG 473
++WN++ + + +QE L + + F +++ N++ +
Sbjct: 1028 QVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1087
Query: 474 CGECSFSNGGHLFAAVNGN-VIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGT 532
C S+ F++ + + +++ L + L+GH G +R ++ D + L +G
Sbjct: 1088 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1147
Query: 533 DGAVYEWNLSTGKRETECVLKSCS--------YNCVTVSPDAKIIFAVG 573
+G + WN+S G+ C S + SPD K++ + G
Sbjct: 1148 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1196
Score = 43.5 bits (101), Expect = 7e-04
Identities = 44/208 (21%), Positives = 76/208 (36%), Gaps = 65/208 (31%)
Query: 404 IATCSLDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDI 463
IATCS+D+ +++WN T EL Y E + ++
Sbjct: 672 IATCSVDKKVKIWNSMTG--ELVHTYDEHSEQVNC------------------------- 704
Query: 464 RSFKEYSVRGCGECSFSNGGHLFAAVNGN---VIHVYTTTSLENISSLKGHTGKIRSIVW 520
C F+N H G+ + ++ E +++ GHT + +
Sbjct: 705 -------------CHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRF 751
Query: 521 NADDSKLISGGTDGAVYEW------------------NLSTGKRETECVLKSCSYNCVTV 562
+ DD L S DG + W NL + + E ++K CS++
Sbjct: 752 SPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS---- 807
Query: 563 SPDAKIIFAVGSDHTLKEIADSLILREI 590
+ A+I+ A + L +I S +L EI
Sbjct: 808 ADGARIMVAAKNKIFLFDIHTSGLLGEI 835
Score = 37.4 bits (85), Expect = 0.047
Identities = 30/120 (25%), Positives = 50/120 (41%), Gaps = 3/120 (2%)
Query: 502 LENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVT 561
L+ L+GH ++ +S+L+S DG V WN+ TG +E + V +
Sbjct: 1034 LDKCIFLRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCD 1092
Query: 562 VSPDAKIIFAVGSDHTLKEIADSLI--LREISAFDVTYTAIVISHSGRMMFVGTSVGTIR 619
+S DA + +D T K + L+ L E+ + S ++ G G IR
Sbjct: 1093 ISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIR 1152
Score = 31.6 bits (70), Expect = 2.6
Identities = 31/162 (19%), Positives = 60/162 (37%), Gaps = 6/162 (3%)
Query: 424 ELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDIRSFKEYSVRGCGECSFSNGG 483
E + YQ+ + + + +K + NL +R + C FS G
Sbjct: 572 ETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHAC----FSEDG 627
Query: 484 HLFAAVNGN-VIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLS 542
A+ + + V+ + E + +K H ++ ++ DD + + D V WN
Sbjct: 628 QRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSM 687
Query: 543 TGKRETECVLKSCSYNCVTVSPDA-KIIFAVGSDHTLKEIAD 583
TG+ S NC + + ++ A GS ++ D
Sbjct: 688 TGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 52.4 bits (124), Expect = 1e-06
Identities = 95/529 (17%), Positives = 187/529 (35%), Gaps = 75/529 (14%)
Query: 98 KVLNNFDFQVQKFISMAFSPDSKYLLAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVY 157
++++ +D ++ F+ S +LL T S+ LW+ + + N V
Sbjct: 679 ELVHTYDEHSEQVNCCHFTNSSHHLLLATG--SSDCFLKLWDLNQKECRNTMFGHTNSVN 736
Query: 158 QVSFSPQDNTQVCVTGNGMFKLLRFAEGT------LKQTSFQRGEPQNYL-----AHTWV 206
FSP D + +G KL +KQ +PQ + +W
Sbjct: 737 HCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS 796
Query: 207 ADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTNGSKS------------LDVIQESES 254
AD ++ K+FLF+ TS ++ E G S L V+ S+
Sbjct: 797 ADGARIMVAAKNKIFLFDI-----HTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQY 851
Query: 255 LIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAGPGRVLLFE------ 308
+E S + A +S + F S+ + L+E
Sbjct: 852 CVELWNTDS------RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCK 905
Query: 309 ------KMEEKDFYRESREIRIPVDP---------QSNDPSQSDKQDVLCLCFSPSEETL 353
K E ++E+ + + VD ++ + V C C SP + +
Sbjct: 906 NSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYI 965
Query: 354 VASTSKNQLYSITMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSI 413
+ + + I + H + + + +A K LI++ S D I
Sbjct: 966 AFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTAD--------EKTLISS-SDDAEI 1016
Query: 414 RLWNYETNTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDIRSFKEYSVRG 473
++WN++ + + +QE L + + F +++ N++ +
Sbjct: 1017 QVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGT 1076
Query: 474 CGECSFSNGGHLFAAVNGN-VIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGT 532
C S+ F++ + + +++ L + L+GH G +R ++ D + L +G
Sbjct: 1077 VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDD 1136
Query: 533 DGAVYEWNLSTGKRETECVLKSCS--------YNCVTVSPDAKIIFAVG 573
+G + WN+S G+ C S + SPD K++ + G
Sbjct: 1137 NGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185
Score = 43.5 bits (101), Expect = 7e-04
Identities = 44/208 (21%), Positives = 76/208 (36%), Gaps = 65/208 (31%)
Query: 404 IATCSLDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDI 463
IATCS+D+ +++WN T EL Y E + ++
Sbjct: 661 IATCSVDKKVKIWNSMTG--ELVHTYDEHSEQVNC------------------------- 693
Query: 464 RSFKEYSVRGCGECSFSNGGHLFAAVNGN---VIHVYTTTSLENISSLKGHTGKIRSIVW 520
C F+N H G+ + ++ E +++ GHT + +
Sbjct: 694 -------------CHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRF 740
Query: 521 NADDSKLISGGTDGAVYEW------------------NLSTGKRETECVLKSCSYNCVTV 562
+ DD L S DG + W NL + + E ++K CS++
Sbjct: 741 SPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWS---- 796
Query: 563 SPDAKIIFAVGSDHTLKEIADSLILREI 590
+ A+I+ A + L +I S +L EI
Sbjct: 797 ADGARIMVAAKNKIFLFDIHTSGLLGEI 824
Score = 37.4 bits (85), Expect = 0.047
Identities = 30/120 (25%), Positives = 50/120 (41%), Gaps = 3/120 (2%)
Query: 502 LENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVT 561
L+ L+GH ++ +S+L+S DG V WN+ TG +E + V +
Sbjct: 1023 LDKCIFLRGHQETVKDFRL-LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCD 1081
Query: 562 VSPDAKIIFAVGSDHTLKEIADSLI--LREISAFDVTYTAIVISHSGRMMFVGTSVGTIR 619
+S DA + +D T K + L+ L E+ + S ++ G G IR
Sbjct: 1082 ISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIR 1141
Score = 31.6 bits (70), Expect = 2.6
Identities = 31/162 (19%), Positives = 60/162 (37%), Gaps = 6/162 (3%)
Query: 424 ELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDIRSFKEYSVRGCGECSFSNGG 483
E + YQ+ + + + +K + NL +R + C FS G
Sbjct: 561 ETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHAC----FSEDG 616
Query: 484 HLFAAVNGN-VIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLS 542
A+ + + V+ + E + +K H ++ ++ DD + + D V WN
Sbjct: 617 QRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSM 676
Query: 543 TGKRETECVLKSCSYNCVTVSPDA-KIIFAVGSDHTLKEIAD 583
TG+ S NC + + ++ A GS ++ D
Sbjct: 677 TGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 52.4 bits (124), Expect = 1e-06
Identities = 56/241 (23%), Positives = 91/241 (37%), Gaps = 55/241 (22%)
Query: 345 CFSPSEETLVASTSKNQLYSITMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLI 404
CF PS + L S+ T+ L ++ KG+ L + HS + +
Sbjct: 401 CFHPSGDKLATSSGDT-----TVKLWDLCKGDCI----LTFEGHSRAVWSCTWHSCGNFV 451
Query: 405 ATCSLDRSIRLWNYETNTLEL-FKEYQEEAYSISLHPSGHFIVVGFADK----------- 452
A+ SLD++ ++W+ + + + SI P + ++ ADK
Sbjct: 452 ASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGI 511
Query: 453 --------LRLMNLLIDDIRSFKEYSVRGCG------------------------ECSFS 480
+ +N I D R S CG E +F
Sbjct: 512 CEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFD 571
Query: 481 NGGHLFAAVNGN-VIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEW 539
+ G + A +GN VIH+ S E I L GH + ++V++ D L SGG+DG V W
Sbjct: 572 SSGRVLAQASGNGVIHLLDLKSGE-IHKLMGHENEAHTVVFSHDGEILFSGGSDGTVRTW 630
Query: 540 N 540
+
Sbjct: 631 S 631
Score = 43.1 bits (100), Expect = 9e-04
Identities = 42/178 (23%), Positives = 78/178 (43%), Gaps = 14/178 (7%)
Query: 377 PAHFEYLM---YPLHSAPITGLATCIRKPLIATCSLDRSIRLWNY----ETNTLELFKEY 429
PA F+Y + + LH P++ ++ K ++ +C DR LW + N L +
Sbjct: 337 PAKFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDR---LWKVLGLPKCNVLLTGFGH 393
Query: 430 QEEAYSISLHPSGHFIVVGFADK-LRLMNLLIDD-IRSFKEYSVRGCGECSFSNGGHLFA 487
+ HPSG + D ++L +L D I +F+ +S R C++ + G+ A
Sbjct: 394 TDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHS-RAVWSCTWHSCGNFVA 452
Query: 488 AVN-GNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTG 544
+ + ++ S +L GHT + SI + + L++ D + W+ TG
Sbjct: 453 SSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG 510
Score = 33.9 bits (76), Expect = 0.52
Identities = 21/70 (30%), Positives = 32/70 (45%), Gaps = 5/70 (7%)
Query: 137 LWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFAEGTLKQTSFQRGE 196
LW+ +K++ IV ID +P +V+F +GNG+ LL G + + E
Sbjct: 546 LWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENE 605
Query: 197 PQNYLAHTWV 206
AHT V
Sbjct: 606 -----AHTVV 610
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 52.4 bits (124), Expect = 1e-06
Identities = 47/194 (24%), Positives = 78/194 (40%), Gaps = 36/194 (18%)
Query: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWNY--ETNTLELFKEYQEEAYSISLHPSGHFI 445
H+ IT +A+ SLDR I++W+ + L + K + + SGHF+
Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
Query: 446 VVGFADKLRLMNLLIDDIRSFKEYSVRGCGECSFSNGGHLFAAVNGNVIHVYTTTSLENI 505
DK NL I ++ + + R CG C +
Sbjct: 289 CTSSWDK----NLKIWNVHTGE---FRNCGAC---------------------------V 314
Query: 506 SSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSPD 565
+ ++GH G + S + D S LISGG D V W+++ G R+ + V +S +
Sbjct: 315 TLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNN 374
Query: 566 AKIIFAVGSDHTLK 579
K I + D T++
Sbjct: 375 KKWILSASKDRTMR 388
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 51.6 bits (122), Expect = 2e-06
Identities = 51/238 (21%), Positives = 93/238 (39%), Gaps = 16/238 (6%)
Query: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWN-YETNTLELFKEYQEEAYSISLHPSGHFIV 446
H A I + L+ + S D + +W+ Y TN + + + PSG+F+
Sbjct: 54 HLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVA 113
Query: 447 VGFADKL-RLMNLLIDD--IRSFKEYSVR----GCGECSFSNGGHLFAAVNGNVIHVYTT 499
G D + + NL + ++ +E S C C F + ++ + ++
Sbjct: 114 CGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSC--CRFLDDNNIVTSSGDTTCALWDI 171
Query: 500 TSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNC 559
+ + + GHTG S+ + D + ISG D + W++ G N
Sbjct: 172 ETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINA 231
Query: 560 VTVSPDAKIIFAVGSDHTLKEIADSLILREISAFD-----VTYTAIVISHSGRMMFVG 612
+ P+ + I GSD + D +E+ F T++ S SGR++F G
Sbjct: 232 ICFFPNGEAI-CTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAG 288
Score = 46.2 bits (108), Expect = 1e-04
Identities = 44/180 (24%), Positives = 75/180 (41%), Gaps = 9/180 (5%)
Query: 366 TMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTL-E 424
T +L +I G+ + ++ H+ LA L + + D S +LW+ T +
Sbjct: 165 TCALWDIETGQ----QKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQ 220
Query: 425 LFKEYQEEAYSISLHPSGHFIVVGFAD-KLRLMNLLIDD--IRSFKEYSVRGCGECSFSN 481
F ++ + +I P+G I G D RL +L D I E + G +FS
Sbjct: 221 TFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSL 280
Query: 482 GGHL-FAAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWN 540
G L FA + +V+ + E + L GH ++ + AD + +G D + WN
Sbjct: 281 SGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 35.4 bits (80), Expect = 0.18
Identities = 18/70 (25%), Positives = 30/70 (42%)
Query: 507 SLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSPDA 566
+L+GH KI ++ W D L+S DG + W+ T + L+S +P
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 567 KIIFAVGSDH 576
+ G D+
Sbjct: 110 NFVACGGLDN 119
>gi|56790932 echinoderm microtubule associated protein like 1
isoform a [Homo sapiens]
Length = 834
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/311 (20%), Positives = 114/311 (36%), Gaps = 52/311 (16%)
Query: 351 ETLVASTSKNQLYSITMS--LTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCS 408
+ ++ T++N + T+S T I++G H+ + GLA K TC
Sbjct: 534 DVILIGTTRNFVLQGTLSGDFTPITQG------------HTDELWGLAIHASKSQFLTCG 581
Query: 409 LDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVVG------FADKLRLMNLLIDD 462
D+ LW+ + K ++ A S HPSG + VG F +L+
Sbjct: 582 HDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVH 641
Query: 463 IRSFKEYSVRGCGECSFSNGGHLFAAVNGNVIHVYTTTS----LENISSLKGHTGKIRSI 518
++ SV +G L + N I++Y + + GH+ I +
Sbjct: 642 TDGNEQLSVMRYSP----DGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHL 697
Query: 519 VWNADDSKLISGGTDGAVYEWNLSTGKR----ETECVLKSCSYNCVTVSPDAKIIFAVGS 574
W+ + L+S D + W S K+ ET ++ +Y C T+ ++ GS
Sbjct: 698 DWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTC-TLGFHVFGVWPEGS 756
Query: 575 DHTLKEIADSLILREISAFDVTYTAIVISHSGRMMFVGTSVGTIRAMKYPL-PLQKEFNE 633
D T A+ +H +++ G G + YP + +
Sbjct: 757 DGT------------------DINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHI 798
Query: 634 YQAHAGPITKV 644
Y H+ +T V
Sbjct: 799 YGGHSSHVTNV 809
Score = 44.3 bits (103), Expect = 4e-04
Identities = 50/230 (21%), Positives = 94/230 (40%), Gaps = 16/230 (6%)
Query: 11 VFGLRSH-VANNIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPNR 69
V+G R NN++ ++ + V YNV+++ Q+ G + + L++ P+R
Sbjct: 245 VYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGH--NDDVKCLAVHPDR 302
Query: 70 RYLAISETV-------QEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSKYL 122
+A + Q P + I++ ++ + FD V I+ + S L
Sbjct: 303 ITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVT-CIAFSKSNGGTNL 361
Query: 123 LAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNG--MFKLL 180
A + L W W+K++ +A V+ N V+ F P D + G F L
Sbjct: 362 CAVDDSNDHVLSVWDWQKEEKLADVKCS--NEAVFAADFHPTDTNIIVTCGKSHLYFWTL 419
Query: 181 RFAEGTLKQTSFQRGE-PQNYLAHTWVADDKIVVGTDTGKLFLFESGDQR 229
+ KQ F++ E P+ L T+ + + G +G + ++ G R
Sbjct: 420 EGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNR 469
>gi|56790930 echinoderm microtubule associated protein like 1
isoform b [Homo sapiens]
Length = 815
Score = 50.8 bits (120), Expect = 4e-06
Identities = 64/311 (20%), Positives = 114/311 (36%), Gaps = 52/311 (16%)
Query: 351 ETLVASTSKNQLYSITMS--LTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCS 408
+ ++ T++N + T+S T I++G H+ + GLA K TC
Sbjct: 515 DVILIGTTRNFVLQGTLSGDFTPITQG------------HTDELWGLAIHASKSQFLTCG 562
Query: 409 LDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVVG------FADKLRLMNLLIDD 462
D+ LW+ + K ++ A S HPSG + VG F +L+
Sbjct: 563 HDKHATLWDAVGHRPVWDKIIEDPAQSSGFHPSGSVVAVGTLTGRWFVFDTETKDLVTVH 622
Query: 463 IRSFKEYSVRGCGECSFSNGGHLFAAVNGNVIHVYTTTS----LENISSLKGHTGKIRSI 518
++ SV +G L + N I++Y + + GH+ I +
Sbjct: 623 TDGNEQLSVMRYSP----DGNFLAIGSHDNCIYIYGVSDNGRKYTRVGKCSGHSSFITHL 678
Query: 519 VWNADDSKLISGGTDGAVYEWNLSTGKR----ETECVLKSCSYNCVTVSPDAKIIFAVGS 574
W+ + L+S D + W S K+ ET ++ +Y C T+ ++ GS
Sbjct: 679 DWSVNSQFLVSNSGDYEILYWVPSACKQVVSVETTRDIEWATYTC-TLGFHVFGVWPEGS 737
Query: 575 DHTLKEIADSLILREISAFDVTYTAIVISHSGRMMFVGTSVGTIRAMKYPL-PLQKEFNE 633
D T A+ +H +++ G G + YP + +
Sbjct: 738 DGT------------------DINAVCRAHEKKLLSTGDDFGKVHLFSYPCSQFRAPSHI 779
Query: 634 YQAHAGPITKV 644
Y H+ +T V
Sbjct: 780 YGGHSSHVTNV 790
Score = 44.3 bits (103), Expect = 4e-04
Identities = 50/230 (21%), Positives = 94/230 (40%), Gaps = 16/230 (6%)
Query: 11 VFGLRSH-VANNIFYFDEQIIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPNR 69
V+G R NN++ ++ + V YNV+++ Q+ G + + L++ P+R
Sbjct: 226 VYGYRGRDCRNNLYLLPTGETVYFIASVVVLYNVEEQLQRHYAGH--NDDVKCLAVHPDR 283
Query: 70 RYLAISETV-------QEKPAITIYELSSIPCRKRKVLNNFDFQVQKFISMAFSPDSKYL 122
+A + Q P + I++ ++ + FD V I+ + S L
Sbjct: 284 ITIATGQVAGTSKDGKQLPPHVRIWDSVTLNTLHVIGIGFFDRAVT-CIAFSKSNGGTNL 342
Query: 123 LAQTSPPESNLVYWLWEKQKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNG--MFKLL 180
A + L W W+K++ +A V+ N V+ F P D + G F L
Sbjct: 343 CAVDDSNDHVLSVWDWQKEEKLADVKCS--NEAVFAADFHPTDTNIIVTCGKSHLYFWTL 400
Query: 181 RFAEGTLKQTSFQRGE-PQNYLAHTWVADDKIVVGTDTGKLFLFESGDQR 229
+ KQ F++ E P+ L T+ + + G +G + ++ G R
Sbjct: 401 EGSSLNKKQGLFEKQEKPKFVLCVTFSENGDTITGDSSGNILVWGKGTNR 450
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 50.4 bits (119), Expect = 5e-06
Identities = 50/242 (20%), Positives = 91/242 (37%), Gaps = 24/242 (9%)
Query: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWN-YETNTLELFKEYQEEAYSISLHPSGHFIV 446
H A I + L+ + S D + +W+ Y TN + + + PSG+++
Sbjct: 54 HLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVA 113
Query: 447 VGFADKL-RLMNLLIDDIRSFKEYSVRGCGE----------CSFSNGGHLFAAVNGNVIH 495
G D + + NL +E +VR E C F + + +
Sbjct: 114 CGGLDNICSIYNL------KTREGNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCA 167
Query: 496 VYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSC 555
++ + + ++ GH+G + S+ + D +SG D + W++ G
Sbjct: 168 LWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVS 227
Query: 556 SYNCVTVSPDAKIIFAVGSDHTLKEIAD-----SLILREISAFDVTYTAIVISHSGRMMF 610
N V+ P+ FA GSD + D L+L T++ S SGR++
Sbjct: 228 DINAVSFFPNG-YAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLL 286
Query: 611 VG 612
G
Sbjct: 287 AG 288
Score = 35.4 bits (80), Expect = 0.18
Identities = 35/158 (22%), Positives = 60/158 (37%), Gaps = 5/158 (3%)
Query: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTL-ELFKEYQEEAYSISLHPSGHFIV 446
HS + L+ + + D S +LW+ + F + + ++S P+G+
Sbjct: 183 HSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFA 242
Query: 447 VGFADKL-RLMNLLIDDIRSFKEYSVRGCGECS--FSNGGHLFAAVNGNV-IHVYTTTSL 502
G D RL +L D + CG S FS G L A + +V+ T
Sbjct: 243 TGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKG 302
Query: 503 ENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWN 540
+ L GH ++ + D + +G D + WN
Sbjct: 303 DRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340
Score = 34.3 bits (77), Expect = 0.40
Identities = 18/70 (25%), Positives = 30/70 (42%)
Query: 507 SLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSPDA 566
+L+GH KI ++ W D L+S DG + W+ T + L+S +P
Sbjct: 50 TLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSG 109
Query: 567 KIIFAVGSDH 576
+ G D+
Sbjct: 110 NYVACGGLDN 119
>gi|145279222 WD repeat domain 66 [Homo sapiens]
Length = 1149
Score = 49.7 bits (117), Expect = 9e-06
Identities = 114/558 (20%), Positives = 217/558 (38%), Gaps = 84/558 (15%)
Query: 22 IFYFDEQ---IIIFPSGNHCVKYNVDQKWQKFIPGSEKSQGMLALSISPNRRYLAISETV 78
++Y E+ ++++ + + YNV + Q + G + L +S +RR++A ++
Sbjct: 263 VYYIREERQRVLLYVCAHTAIIYNVFRNNQYHLQGHANI--ISCLCVSEDRRWIATADKG 320
Query: 79 QEKPAITIYELSSIPCRKRKVLNNFDF--QVQKFISMAFSPDSKYLLAQTSPPESNLVYW 136
+ I + IP V FD + ++MA + D+KYL + + W
Sbjct: 321 PDCLVIIWDSFTGIP-----VHTIFDSCPEGNGIMAMAMTHDAKYLATISDAEVQKVCIW 375
Query: 137 LWEK--QKVMAIVRIDTQNNPVYQVSFSPQDNTQVCVTGNGMFKLLRFA----------- 183
W + + + T+ V+F+P +N + + N + + +A
Sbjct: 376 KWTLAVETPACTLELPTEYGVQNYVTFNPTNNKE--LVSNSKTRAIYYAWYEERDTLAHS 433
Query: 184 EGTLKQTSFQR--GEPQNYLAHTWVADDKIVVGTDTGKLFLFESGDQRWETSIMVKEPTN 241
L + +F + G+ + H + +I+ T GKL +++ S + P
Sbjct: 434 APLLTEKTFNKLVGKFSQSIFHLNLT--QILSATMEGKLVVWDIHRPPSSASTFLGFPYI 491
Query: 242 GSKSLDVIQESESLIEFPPVSSPLPSYEQMVAASSHSQMSMPQVFAIAAYSKGFACSAGP 301
L +Q+ E V + + SY + + + + YS G
Sbjct: 492 KPCKLVHLQK-----EGITVLTTIDSYIVTGDIKGNIKFYDHTLSIVNWYSH---LKLGA 543
Query: 302 GRVLLFEKMEEKDFYRESREIRIPVDPQSNDPSQSDKQDVLCLCFSPSEETLVASTSKNQ 361
R L F K P + + P + K D+ L + TS
Sbjct: 544 IRTLSFSKTPATP----------PTEKSNYPPDCTLKGDLFVL------RNFIIGTSDAA 587
Query: 362 LYSITMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNYETN 421
+Y +T T++ K ++ I ++ +PLIA S+ I++WNYE N
Sbjct: 588 VYHLTTDGTKLEK---------LFVEPKDAICAISCHPYQPLIAIGSICGMIKVWNYE-N 637
Query: 422 TLELFKEYQEE---AYSISLHPSGHFIVVGFADK----LRLMNLLIDDIRSFKEYSVRGC 474
LF E+ S++ +P G + GF + L M+L + FK YS
Sbjct: 638 KQYLFSRVFEKGLGVQSLTYNPEGALLGAGFTEGTVYILDAMSLENESPEPFK-YSRTSV 696
Query: 475 GECSFSNGGHLFAAVNGN-VIHVYTTT------SLENISSLKGHTGKIRSIVW----NAD 523
SFS+ A + + + VY E ++ L+ H IRS+++ +++
Sbjct: 697 THISFSHDSQYMATADRSFTVAVYMLVVRNGQRVWEYLARLRSHRKSIRSLLFGVYLDSN 756
Query: 524 DSKLISGGTDGAVYEWNL 541
+ +L+S GTD + E++L
Sbjct: 757 EPRLLSLGTDRLLIEYDL 774
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 49.7 bits (117), Expect = 9e-06
Identities = 35/149 (23%), Positives = 69/149 (46%), Gaps = 19/149 (12%)
Query: 404 IATCSLDRSIRLWNYETNTLEL-FKEYQEEAYSISLHPSGHFIVVG-------------F 449
I + +D I++W+ N L + + + +SL G +++ F
Sbjct: 208 IISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPF 267
Query: 450 ADKLRLMNLLIDDIRSFKEYSVRGCGECSFSNGGHLFAAVNGN-VIHVYTTTSLENISSL 508
A K R + + ++ +F++ +R CS+S G AA + + ++V+ TTS + L
Sbjct: 268 APKERCVKIFQGNVHNFEKNLLR----CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL 323
Query: 509 KGHTGKIRSIVWNADDSKLISGGTDGAVY 537
GH G I + ++ D+ +IS +D +Y
Sbjct: 324 PGHAGSINEVAFHPDEPIIISASSDKRLY 352
Score = 47.0 bits (110), Expect = 6e-05
Identities = 34/129 (26%), Positives = 55/129 (42%), Gaps = 2/129 (1%)
Query: 477 CSFS-NGGHLFAAVNGNVIHVYTTTS-LENISSLKGHTGKIRSIVWNADDSKLISGGTDG 534
C F NG L +A +I ++ +N ++LKGH+G + + +N D S L S TD
Sbjct: 72 CKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDK 131
Query: 535 AVYEWNLSTGKRETECVLKSCSYNCVTVSPDAKIIFAVGSDHTLKEIADSLILREISAFD 594
V W+ TG+R + N + + GSD ++ D I F
Sbjct: 132 TVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ 191
Query: 595 VTYTAIVIS 603
TY + ++
Sbjct: 192 NTYQVLAVT 200
Score = 42.4 bits (98), Expect = 0.001
Identities = 41/190 (21%), Positives = 78/190 (41%), Gaps = 18/190 (9%)
Query: 403 LIATCSLDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDD 462
L+ T S D +++LW+ + + +++ + + I+ G D ++ + D
Sbjct: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDN----DIKVWD 221
Query: 463 IRSFK-EYSVRG-----CGECSFSNGGHLFAAVNGNVIHVYTTTSLEN----ISSLKGHT 512
+R K Y++RG G S G +L + N + V+ + +G+
Sbjct: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNV 281
Query: 513 GKIRSIV----WNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSPDAKI 568
+ W+ D SK+ +G D VY W+ ++ + + + S N V PD I
Sbjct: 282 HNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
Query: 569 IFAVGSDHTL 578
I + SD L
Sbjct: 342 IISASSDKRL 351
Score = 29.6 bits (65), Expect = 9.9
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 505 ISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTV-- 562
I L GH G++ ++ + S L S G D + WN+ G + LK S + +
Sbjct: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV-YGDCDNYATLKGHSGAVMELHY 117
Query: 563 SPDAKIIFAVGSDHTL 578
+ D ++F+ +D T+
Sbjct: 118 NTDGSMLFSASTDKTV 133
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 49.3 bits (116), Expect = 1e-05
Identities = 43/194 (22%), Positives = 83/194 (42%), Gaps = 6/194 (3%)
Query: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWNYETNTLE-LFKEYQEEAYSISLHPSGHFIV 446
H +P+T + ++ + S D +I++W+YET E K + + IS SG +
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLA 166
Query: 447 VGFADK-LRLMNLL-IDDIRSFKEYSVRGCGECSFSNGGHLFAAVNGNVIHVYTTTSLEN 504
AD ++L + + IR+ + NG H+ +A I ++ +
Sbjct: 167 SCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC 226
Query: 505 ISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSP 564
+ + GH +R + N D + + S D V W ++T + + E C++ +P
Sbjct: 227 VKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAP 286
Query: 565 D---AKIIFAVGSD 575
+ + I A GS+
Sbjct: 287 ESSYSSISEATGSE 300
Score = 40.8 bits (94), Expect = 0.004
Identities = 48/255 (18%), Positives = 94/255 (36%), Gaps = 51/255 (20%)
Query: 403 LIATCSLDRSIRLWNYET-NTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLID 461
L+A+CS D +I+LW+++ + + S+++ P+G IV DK
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDK--------- 214
Query: 462 DIRSFKEYSVRGCGECSFSNGGH---------------LFAAVNGNVIHVYTTTSLENIS 506
+ K + V+ G C + GH + + N + V+ + E +
Sbjct: 215 ---TIKMWEVQ-TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKA 270
Query: 507 SLKGHTGKIRSIVWNADDSK--------------------LISGGTDGAVYEWNLSTGKR 546
L+ H + I W + S L+SG D + W++STG
Sbjct: 271 ELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMC 330
Query: 547 ETECVLKSCSYNCVTVSPDAKIIFAVGSDHTLK--EIADSLILREISAFDVTYTAIVISH 604
V V K I + D TL+ + + ++ ++A + T++
Sbjct: 331 LMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHK 390
Query: 605 SGRMMFVGTSVGTIR 619
+ + G+ T++
Sbjct: 391 TAPYVVTGSVDQTVK 405
Score = 32.0 bits (71), Expect = 2.0
Identities = 19/102 (18%), Positives = 44/102 (43%), Gaps = 2/102 (1%)
Query: 507 SLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSPDA 566
+L GH + ++++ S ++S D + W+ TG E + S ++
Sbjct: 103 ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162
Query: 567 KIIFAVGSDHTLK--EIADSLILREISAFDVTYTAIVISHSG 606
K++ + +D T+K + +R + D +++ I +G
Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNG 204
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 49.3 bits (116), Expect = 1e-05
Identities = 48/238 (20%), Positives = 91/238 (38%), Gaps = 16/238 (6%)
Query: 388 HSAPITGLATCIRKPLIATCSLDRSIRLWN-YETNTLELFKEYQEEAYSISLHPSGHFIV 446
H A I + L+ + S D + +W+ Y TN + + + PSG+++
Sbjct: 54 HLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVA 113
Query: 447 VGFADKL-RLMNLLIDD--IRSFKEYSVR----GCGECSFSNGGHLFAAVNGNVIHVYTT 499
G D + + NL + +R +E + C C F + + + ++
Sbjct: 114 CGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSC--CRFLDDNQIVTSSGDTTCALWDI 171
Query: 500 TSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNC 559
+ + ++ GHTG + S+ D +SG D + W++ G N
Sbjct: 172 ETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINA 231
Query: 560 VTVSPDAKIIFAVGSDHTLKEIADSLILREISAFD-----VTYTAIVISHSGRMMFVG 612
+ P+ FA GSD + D +E+ + T++ S SGR++ G
Sbjct: 232 ICFFPNGN-AFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAG 288
Score = 38.1 bits (87), Expect = 0.028
Identities = 40/182 (21%), Positives = 72/182 (39%), Gaps = 13/182 (7%)
Query: 366 TMSLTEISKGEPAHFEYLMYPLHSAPITGLATCIRKPLIATCSLDRSIRLWNY-ETNTLE 424
T +L +I G+ + + H+ + L+ L + + D S +LW+ E +
Sbjct: 165 TCALWDIETGQ----QTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQ 220
Query: 425 LFKEYQEEAYSISLHPSGHFIVVGFADKL-RLMNLLIDDIRSFKEYS----VRGCGECSF 479
F ++ + +I P+G+ G D RL +L D + YS + G SF
Sbjct: 221 TFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRAD--QELMTYSHDNIICGITSVSF 278
Query: 480 SNGGHLFAAVNGNV-IHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYE 538
S G L A + +V+ + L GH ++ + D + +G D +
Sbjct: 279 SKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKI 338
Query: 539 WN 540
WN
Sbjct: 339 WN 340
Score = 35.8 bits (81), Expect = 0.14
Identities = 31/155 (20%), Positives = 61/155 (39%), Gaps = 15/155 (9%)
Query: 507 SLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSPDA 566
+L+GH KI ++ W D L+S DG + W+ T + L+S +P
Sbjct: 50 TLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSG 109
Query: 567 KIIFAVGSDHTLKEIADSLILREISAFDVTYTAIVISHSGRMMF--------VGTSVGTI 618
+ G D+ S+ + +V + + H+G + + TS G
Sbjct: 110 NYVACGGLDNIC-----SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDT 164
Query: 619 RAMKYPLPLQKEFNEYQAHAGPITKVSRTLSPGTQ 653
+ + ++ + H G + +S +L+P T+
Sbjct: 165 TCALWDIETGQQTTTFTGHTGDV--MSLSLAPDTR 197
>gi|148727341 serine/threonine kinase receptor associated protein
[Homo sapiens]
Length = 350
Score = 49.3 bits (116), Expect = 1e-05
Identities = 43/180 (23%), Positives = 72/180 (40%), Gaps = 15/180 (8%)
Query: 410 DRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLL-IDDIRSFKE 468
D+++RLW++ T T + S+ P G +V+ + + + + +D I+SF+
Sbjct: 163 DKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEA 222
Query: 469 YSVRGCGECSFSNGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLI 528
+ L A ++ Y S E + S KGH G I + ++ D
Sbjct: 223 PATINSASLH-PEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYA 281
Query: 529 SGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSPDA------KIIFAVGSDHTLKEIA 582
SG DG + W GK + CV D+ KI F ++ L+EIA
Sbjct: 282 SGSEDGTLRLWQTVVGKTYG-------LWKCVLPEEDSGELAKPKIGFPETTEEELEEIA 334
Score = 35.0 bits (79), Expect = 0.24
Identities = 34/164 (20%), Positives = 66/164 (40%), Gaps = 9/164 (5%)
Query: 481 NGGHLFAAVNGNVIHVYTTTSLE-NISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEW 539
+ +L ++ +Y E + GHT I+ +W ++D +++S D V W
Sbjct: 111 DSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILS-ADDKTVRLW 169
Query: 540 NLSTGKRETECVLKSCSYNCVTVSPDAKIIFAVGSDHTLKEIA--DSLILREISAFDVTY 597
+ +T E + + + S + + P+ +I+ + IA ++ L I +F+
Sbjct: 170 DHAT-MTEVKSLNFNMSVSSMEYIPEGEILVITYG----RSIAFHSAVSLDPIKSFEAPA 224
Query: 598 TAIVISHSGRMMFVGTSVGTIRAMKYPLPLQKEFNEYQAHAGPI 641
T S F+ + KY +E Y+ H GPI
Sbjct: 225 TINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPI 268
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 49.3 bits (116), Expect = 1e-05
Identities = 34/141 (24%), Positives = 65/141 (46%), Gaps = 2/141 (1%)
Query: 481 NGGHLFAAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWN 540
NG L ++ +I ++ + +L GH +I + W++D S+L+S D + W+
Sbjct: 52 NGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWD 111
Query: 541 LSTGKRETECVLKSCSYNCVTVSPDAKIIFAVGSDHTLK--EIADSLILREISAFDVTYT 598
+ +GK S C +P + +I + D T+K E+ L+ +SA +
Sbjct: 112 VRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVS 171
Query: 599 AIVISHSGRMMFVGTSVGTIR 619
A+ + SG ++ G+ G R
Sbjct: 172 AVHFNCSGSLIVSGSYDGLCR 192
Score = 42.7 bits (99), Expect = 0.001
Identities = 48/199 (24%), Positives = 82/199 (41%), Gaps = 35/199 (17%)
Query: 403 LIATCSLDRSIRLWNYETNT-LELFKEYQEEAYSISLHPSGHFIVVGFADKL-------- 453
LI + S D ++++W +T L+ + + ++ + SG IV G D L
Sbjct: 139 LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAAS 198
Query: 454 -RLMNLLIDDIR---SFKEYSVRGCGECSFSNGGHLFAAVNGNVIHVYTTTSLENISSLK 509
+ + L+DD SF ++S NG ++ A N + ++ + + +
Sbjct: 199 GQCLKTLVDDDNPPVSFVKFS---------PNGKYILTATLDNTLKLWDYSRGRCLKTYT 249
Query: 510 GHTGKIRSIVWN---ADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVS--- 563
GH + I N ++SG D VY WNL T E V K + V +S
Sbjct: 250 GHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQT----KEIVQKLQGHTDVVISAAC 305
Query: 564 -PDAKII--FAVGSDHTLK 579
P +I A+ +D T+K
Sbjct: 306 HPTENLIASAALENDKTIK 324
Score = 40.0 bits (92), Expect = 0.007
Identities = 42/192 (21%), Positives = 82/192 (42%), Gaps = 28/192 (14%)
Query: 404 IATCSLDRSIRLWNYETNTLELFKEYQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDI 463
+A+ S DR I +W +Y++ Y +L S V +D RL++ D
Sbjct: 56 LASSSADRLIIIWGAYDG------KYEKTLYGHNLEISD---VAWSSDSSRLVSA--SDD 104
Query: 464 RSFKEYSVRGCGECSFSNGGH---------------LFAAVNGNVIHVYTTTSLENISSL 508
++ K + VR G+C + GH + + + ++ + + + +L
Sbjct: 105 KTLKLWDVRS-GKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 509 KGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGK-RETECVLKSCSYNCVTVSPDAK 567
H+ + ++ +N S ++SG DG W+ ++G+ +T + + V SP+ K
Sbjct: 164 SAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGK 223
Query: 568 IIFAVGSDHTLK 579
I D+TLK
Sbjct: 224 YILTATLDNTLK 235
Score = 38.1 bits (87), Expect = 0.028
Identities = 26/119 (21%), Positives = 54/119 (45%), Gaps = 2/119 (1%)
Query: 429 YQEEAYSISLHPSGHFIVVGFADKLRLMNLLIDDI--RSFKEYSVRGCGECSFSNGGHLF 486
+ E S+ P+G ++ AD+L ++ D ++ +++ S+ L
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLV 99
Query: 487 AAVNGNVIHVYTTTSLENISSLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGK 545
+A + + ++ S + + +LKGH+ + +N + +ISG D V W + TGK
Sbjct: 100 SASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 48.5 bits (114), Expect = 2e-05
Identities = 51/233 (21%), Positives = 95/233 (40%), Gaps = 27/233 (11%)
Query: 408 SLDRSIRLWNYETNTL-ELFKEYQEEAYSISLHPSGHFIVVGFADK-LRLMNLLIDDIRS 465
S D ++RLW+ T T F + ++ S++ IV G DK ++L N L
Sbjct: 82 SWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL-----G 136
Query: 466 FKEYSVR--------GCGECSFSNGGHLFAAVNGN-VIHVYTTTSLENISSLKGHTGKIR 516
+Y+V+ C S ++ + + + ++ V+ + + ++ GHTG +
Sbjct: 137 VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN 196
Query: 517 SIVWNADDSKLISGGTDGAVYEWNLSTGKR----------ETECVLKSCSYNCVTVSPDA 566
++ + D S SGG DG W+L+ GK C + + C P
Sbjct: 197 TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSI 256
Query: 567 KIIFAVGSDHTLKEIADSLILREISAFDVTYTAIVISHSGRMMFVGTSVGTIR 619
K I+ + + E+ +I A T++ S G+ +F G + +R
Sbjct: 257 K-IWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVR 308
Score = 42.7 bits (99), Expect = 0.001
Identities = 48/231 (20%), Positives = 92/231 (39%), Gaps = 42/231 (18%)
Query: 339 QDVLCLCFSPSEETLVASTSKNQLYSI--TMSLTEISKGEPAHFEYLMYPLHSAPITGLA 396
+DVL + FS S+ + S S+++ + T+ + + + + +H E++
Sbjct: 106 KDVLSVAFS-SDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWV------------- 151
Query: 397 TCIR------KPLIATCSLDRSIRLWNYETNTLELFKEYQEEAY--SISLHPSGHFIVVG 448
+C+R P+I +C D+ +++WN L+ Y ++++ P G G
Sbjct: 152 SCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT-NHIGHTGYLNTVTVSPDGSLCASG 210
Query: 449 FADKLRLMNLLIDDIRSFKE-YSVRG---CGECSFSNGGHLFAAVNGNVIHVYTTTSLEN 504
D ++ D+ K Y++ G FS + A G I ++
Sbjct: 211 GKDG----QAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATGPSIKIWDLEGKII 266
Query: 505 ISSLK---------GHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKR 546
+ LK + S+ W+AD L +G TD V W ++ G R
Sbjct: 267 VDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR 317
Score = 37.0 bits (84), Expect = 0.062
Identities = 21/73 (28%), Positives = 36/73 (49%)
Query: 507 SLKGHTGKIRSIVWNADDSKLISGGTDGAVYEWNLSTGKRETECVLKSCSYNCVTVSPDA 566
+L+GH+ + +V ++D +SG DG + W+L+TG V + V S D
Sbjct: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN 117
Query: 567 KIIFAVGSDHTLK 579
+ I + D T+K
Sbjct: 118 RQIVSGSRDKTIK 130
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,617,026
Number of Sequences: 37866
Number of extensions: 1188894
Number of successful extensions: 3958
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 155
Number of HSP's successfully gapped in prelim test: 90
Number of HSP's that attempted gapping in prelim test: 2813
Number of HSP's gapped (non-prelim): 974
length of query: 698
length of database: 18,247,518
effective HSP length: 109
effective length of query: 589
effective length of database: 14,120,124
effective search space: 8316753036
effective search space used: 8316753036
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.