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Search of human proteins with 22547221
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|22547221 tolloid-like 1 [Homo sapiens]
(1013 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|22547221 tolloid-like 1 [Homo sapiens] 2153 0.0
gi|6912724 tolloid-like 2 [Homo sapiens] 1590 0.0
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 1583 0.0
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom... 1120 0.0
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom... 1116 0.0
gi|126091152 cubilin [Homo sapiens] 320 4e-87
gi|72384339 CUB domain containing protein 2 [Homo sapiens] 221 4e-57
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 218 2e-56
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 218 2e-56
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 218 2e-56
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 213 1e-54
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 207 3e-53
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens] 169 9e-42
gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [H... 167 4e-41
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr... 167 4e-41
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr... 167 4e-41
gi|13899255 membrane frizzled-related protein [Homo sapiens] 160 4e-39
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens] 158 3e-38
gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens] 152 1e-36
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens] 152 1e-36
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens] 152 1e-36
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens] 152 1e-36
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens] 152 1e-36
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens] 152 1e-36
gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens] 151 3e-36
gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens] 151 3e-36
gi|148539844 deleted in malignant brain tumors 1 isoform c precu... 151 3e-36
gi|148539842 deleted in malignant brain tumors 1 isoform b precu... 151 3e-36
gi|148539840 deleted in malignant brain tumors 1 isoform a precu... 151 3e-36
gi|66347875 complement component 1, r subcomponent [Homo sapiens] 149 1e-35
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 2153 bits (5578), Expect = 0.0
Identities = 1013/1013 (100%), Positives = 1013/1013 (100%)
Query: 1 MGLGTLSPRMLVWLVASGIVFYGELWVCAGLDYDYTFDGNEEDKTETIDYKDPCKAAVFW 60
MGLGTLSPRMLVWLVASGIVFYGELWVCAGLDYDYTFDGNEEDKTETIDYKDPCKAAVFW
Sbjct: 1 MGLGTLSPRMLVWLVASGIVFYGELWVCAGLDYDYTFDGNEEDKTETIDYKDPCKAAVFW 60
Query: 61 GDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTTGGLGDHAMSKKRGALYQLIDRIRRIGF 120
GDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTTGGLGDHAMSKKRGALYQLIDRIRRIGF
Sbjct: 61 GDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTTGGLGDHAMSKKRGALYQLIDRIRRIGF 120
Query: 121 GLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQ 180
GLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQ
Sbjct: 121 GLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRTERIWPGGVIPYVIGGNFTGSQRAMFKQ 180
Query: 181 AMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVH 240
AMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVH
Sbjct: 181 AMRHWEKHTCVTFIERSDEESYIVFTYRPCGCCSYVGRRGNGPQAISIGKNCDKFGIVVH 240
Query: 241 ELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYA 300
ELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYA
Sbjct: 241 ELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQEYNFLKMEPGEVNSLGERYDFDSIMHYA 300
Query: 301 RNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNL 360
RNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNL
Sbjct: 301 RNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLSKGDIAQARKLYRCPACGETLQESNGNL 360
Query: 361 SSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLL 420
SSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLL
Sbjct: 361 SSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLL 420
Query: 421 GRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPD 480
GRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPD
Sbjct: 421 GRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPD 480
Query: 481 DYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYD 540
DYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYD
Sbjct: 481 DYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYD 540
Query: 541 KPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCA 600
KPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCA
Sbjct: 541 KPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCA 600
Query: 601 CEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKF 660
CEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKF
Sbjct: 601 CEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKF 660
Query: 661 EFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSK 720
EFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSK
Sbjct: 661 EFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSK 720
Query: 721 KGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHS 780
KGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHS
Sbjct: 721 KGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHS 780
Query: 781 PSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETE 840
PSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETE
Sbjct: 781 PSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETE 840
Query: 841 KSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDL 900
KSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDL
Sbjct: 841 KSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKPRDL 900
Query: 901 YSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAV 960
YSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAV
Sbjct: 901 YSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAV 960
Query: 961 GLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK 1013
GLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK
Sbjct: 961 GLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK 1013
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 1590 bits (4117), Expect = 0.0
Identities = 723/981 (73%), Positives = 830/981 (84%), Gaps = 1/981 (0%)
Query: 34 DYT-FDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHT 92
DY+ DG E + + Y DPCKAAVFWGDIALD++DL +F ID+ D T+ G GH+
Sbjct: 35 DYSELDGEEGTEQQLEHYHDPCKAAVFWGDIALDEDDLKLFHIDKARDWTKQTVGATGHS 94
Query: 93 TGGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSR 152
TGGL + A G E + L + + RV RA TSR
Sbjct: 95 TGGLEEQASESSPDTTAMDTGTKEAGKDGRENTTLLHSPGTLHAAAKTFSPRVRRATTSR 154
Query: 153 TERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGC 212
TERIWPGGVIPYVIGGNFTGSQRA+FKQAMRHWEKHTCVTFIER+DEES+IVF+YR CGC
Sbjct: 155 TERIWPGGVIPYVIGGNFTGSQRAIFKQAMRHWEKHTCVTFIERTDEESFIVFSYRTCGC 214
Query: 213 CSYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQ 272
CSYVGRRG GPQAISIGKNCDKFGIV HELGHV+GFWHEHTRPDRD HVTIIRENIQPGQ
Sbjct: 215 CSYVGRRGGGPQAISIGKNCDKFGIVAHELGHVVGFWHEHTRPDRDQHVTIIRENIQPGQ 274
Query: 273 EYNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRL 332
EYNFLKME GEV+SLGE YDFDSIMHYARNTFSRG+FLDTILP +DDNG+RP IGQR RL
Sbjct: 275 EYNFLKMEAGEVSSLGETYDFDSIMHYARNTFSRGVFLDTILPRQDDNGVRPTIGQRVRL 334
Query: 333 SKGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFT 392
S+GDIAQARKLY+CPACGETLQ++ GN S+PGFPNGYPSY+HC+WR+SVTPGEKIVLNFT
Sbjct: 335 SQGDIAQARKLYKCPACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFT 394
Query: 393 TMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGK 452
+MDL+KS LCWYDY+EVRDGYWRK+PLLGRFCGDK+PE L STDSR+W+EFRSSSN +GK
Sbjct: 395 SMDLFKSRLCWYDYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGK 454
Query: 453 GFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERH 512
GF A YEA CGG++ K+ GQIQSPNYPDDYRP KECVW+ITVSE +HVGLTFQ+FEIERH
Sbjct: 455 GFFAAYEATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERH 514
Query: 513 DNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFF 572
D+CAYDYLEVRDG +E S LIG FCGY+KPED++S+SN LWMKFVSDG++NKAGFAANFF
Sbjct: 515 DSCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFF 574
Query: 573 KEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTP 632
KE DEC+ PD GGCE RC+NTLGSY+CAC+PGYEL D++ CE ACGG +TKLNGTIT+P
Sbjct: 575 KEVDECSWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSP 634
Query: 633 GWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKF 692
GWPKEYP NKNCVWQVVAP QYRIS++FE FELEGN+VCKYD+VE+ SGLS ++KLHG+F
Sbjct: 635 GWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRF 694
Query: 693 CGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSY 752
CG+E PEVITSQ NNMR+EFKSDNTVSK+GF+AHFFSDKDEC+KDNGGCQHECVNT GSY
Sbjct: 695 CGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGCQHECVNTFGSY 754
Query: 753 MCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRI 812
+C+CRNG+ LH+N HDCKEA C KI S G + SPNWPDKYPSR+ECTW IS+T GHR+
Sbjct: 755 LCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRV 814
Query: 813 KLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDA 872
KL F+EFEIEQHQECAYDHLE++DG +PILGR CG+K PDP VA+G+ MF+RF SDA
Sbjct: 815 KLTFNEFEIEQHQECAYDHLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDA 874
Query: 873 SVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELS 932
SVQRKGFQA HSTECGGRLKAE + ++LYSHAQFGDNNYP + C+W++V+E G +EL+
Sbjct: 875 SVQRKGFQAVHSTECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELT 934
Query: 933 FQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTIN 992
F+TFEVEEEADCGYDY+E +DG DS+A LGRFCGSGP EEIYS GDS++I F TDDTIN
Sbjct: 935 FRTFEVEEEADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTIN 994
Query: 993 KKGFHIRYKSIRYPDTTHTKK 1013
KKGFH RY S ++ D H KK
Sbjct: 995 KKGFHARYTSTKFQDALHMKK 1015
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 1583 bits (4098), Expect = 0.0
Identities = 713/980 (72%), Positives = 842/980 (85%), Gaps = 20/980 (2%)
Query: 34 DYTFDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTT 93
DYT+D EED +E ++YKDPCKAA F GDIALD+EDL FQ+ + +DL + HT
Sbjct: 27 DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRR-------HTA 79
Query: 94 GGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRT 153
++ ++ + N + ++ G ++R RAATSR
Sbjct: 80 ----------RKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRG---RSRSRRAATSRP 126
Query: 154 ERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCC 213
ER+WP GVIP+VIGGNFTGSQRA+F+QAMRHWEKHTCVTF+ER+DE+SYIVFTYRPCGCC
Sbjct: 127 ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCC 186
Query: 214 SYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQE 273
SYVGRRG GPQAISIGKNCDKFGIVVHELGHV+GFWHEHTRPDRD HV+I+RENIQPGQE
Sbjct: 187 SYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQE 246
Query: 274 YNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLS 333
YNFLKMEP EV SLGE YDFDSIMHYARNTFSRG+FLDTI+P + NG++P IGQRTRLS
Sbjct: 247 YNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLS 306
Query: 334 KGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT 393
KGDIAQARKLY+CPACGETLQ+S GN SSP +PNGY ++ HC+WR+SVTPGEKI+LNFT+
Sbjct: 307 KGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS 366
Query: 394 MDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKG 453
+DLY+S LCWYDY+EVRDG+WRK+PL GRFCG KLPE + STDSR+W+EFRSSSNWVGKG
Sbjct: 367 LDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKG 426
Query: 454 FAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD 513
F AVYEAICGG+++K+ G IQSPNYPDDYRP K C+W+I VSE +HVGLTFQSFEIERHD
Sbjct: 427 FFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD 486
Query: 514 NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK 573
+CAYDYLEVRDG SE+S LIGR+CGY+KP+DI+STS+ LW+KFVSDG++NKAGFA NFFK
Sbjct: 487 SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK 546
Query: 574 EEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPG 633
E DEC++P+RGGCEQRCLNTLGSY+C+C+PGYEL PD+R CEAACGG LTKLNG+IT+PG
Sbjct: 547 EVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPG 606
Query: 634 WPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFC 693
WPKEYPPNKNC+WQ+VAPTQYRIS++F+FFE EGN+VCKYD+VE+ SGL+++SKLHGKFC
Sbjct: 607 WPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
Query: 694 GAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYM 753
G+E PEVITSQ+NNMR+EFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQ +CVNT GSY
Sbjct: 667 GSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQQDCVNTFGSYE 726
Query: 754 CQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIK 813
CQCR+GFVLHDNKHDCKEA C+ K+ S SG ITSPNWPDKYPS+KECTW IS+TPGHR+K
Sbjct: 727 CQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVK 786
Query: 814 LAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDAS 873
L F E +IE ECAYDHLEVFDG K+P+LGR CG+K P+P++ATG++MF+RF SD S
Sbjct: 787 LTFMEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNS 846
Query: 874 VQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSF 933
VQRKGFQA+H+TECGG+++A+ K +DLYSHAQFGDNNYPG VDCEW++V+E G +EL F
Sbjct: 847 VQRKGFQASHATECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVF 906
Query: 934 QTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINK 993
QTFEVEEE DCGYDY+ELFDG DSTA LGR+CGSGPPEE+YS GDSVL+ FH+DDTI K
Sbjct: 907 QTFEVEEETDCGYDYMELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITK 966
Query: 994 KGFHIRYKSIRYPDTTHTKK 1013
KGFH+RY S ++ DT H++K
Sbjct: 967 KGFHLRYTSTKFQDTLHSRK 986
>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
sapiens]
Length = 730
Score = 1120 bits (2897), Expect = 0.0
Identities = 510/711 (71%), Positives = 604/711 (84%), Gaps = 20/711 (2%)
Query: 34 DYTFDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTT 93
DYT+D EED +E ++YKDPCKAA F GDIALD+EDL FQ+ + +DL + HT
Sbjct: 27 DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRR-------HTA 79
Query: 94 GGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRT 153
++ ++ + N + ++ G ++R RAATSR
Sbjct: 80 ----------RKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRG---RSRSRRAATSRP 126
Query: 154 ERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCC 213
ER+WP GVIP+VIGGNFTGSQRA+F+QAMRHWEKHTCVTF+ER+DE+SYIVFTYRPCGCC
Sbjct: 127 ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCC 186
Query: 214 SYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQE 273
SYVGRRG GPQAISIGKNCDKFGIVVHELGHV+GFWHEHTRPDRD HV+I+RENIQPGQE
Sbjct: 187 SYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQE 246
Query: 274 YNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLS 333
YNFLKMEP EV SLGE YDFDSIMHYARNTFSRG+FLDTI+P + NG++P IGQRTRLS
Sbjct: 247 YNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLS 306
Query: 334 KGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT 393
KGDIAQARKLY+CPACGETLQ+S GN SSP +PNGY ++ HC+WR+SVTPGEKI+LNFT+
Sbjct: 307 KGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS 366
Query: 394 MDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKG 453
+DLY+S LCWYDY+EVRDG+WRK+PL GRFCG KLPE + STDSR+W+EFRSSSNWVGKG
Sbjct: 367 LDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKG 426
Query: 454 FAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD 513
F AVYEAICGG+++K+ G IQSPNYPDDYRP K C+W+I VSE +HVGLTFQSFEIERHD
Sbjct: 427 FFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD 486
Query: 514 NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK 573
+CAYDYLEVRDG SE+S LIGR+CGY+KP+DI+STS+ LW+KFVSDG++NKAGFA NFFK
Sbjct: 487 SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK 546
Query: 574 EEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPG 633
E DEC++P+RGGCEQRCLNTLGSY+C+C+PGYEL PD+R CEAACGG LTKLNG+IT+PG
Sbjct: 547 EVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPG 606
Query: 634 WPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFC 693
WPKEYPPNKNC+WQ+VAPTQYRIS++F+FFE EGN+VCKYD+VE+ SGL+++SKLHGKFC
Sbjct: 607 WPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
Query: 694 GAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHE 744
G+E PEVITSQ+NNMR+EFKSDNTVSKKGFKAHFFS+K + G H+
Sbjct: 667 GSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPALQPPRGRPHQ 717
Score = 296 bits (757), Expect = 9e-80
Identities = 155/426 (36%), Positives = 225/426 (52%), Gaps = 45/426 (10%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
CG ++ + G SP YP+ Y CVW+I+V+ + L F S ++ R C YDY+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
VRDG +PL GRFCG PE I ST + LW++F S GF A +
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
Query: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPN 641
EA CGG + K G I +P +P +Y P+
Sbjct: 432 ---------------------------------EAICGGDVKKDYGHIQSPNYPDDYRPS 458
Query: 642 KNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVI 701
K C+W++ + + + F+ FE+E ++ C YDY+E+ G S S L G++CG E P+ I
Sbjct: 459 KVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDI 518
Query: 702 TSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDN-GGCQHECVNTMGSYMCQCRNGF 760
S + + ++F SD +++K GF +FF + DECS+ N GGC+ C+NT+GSY C C G+
Sbjct: 519 KSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGY 578
Query: 761 VLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFE 820
L +K C EA C + +G ITSP WP +YP K C W++ A +RI L F FE
Sbjct: 579 ELAPDKRRC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
Query: 821 IEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQ 880
E + C YD +EV G T S + G+ CG++ P+ + + N M V F SD +V +KGF+
Sbjct: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
Query: 881 ATHSTE 886
A +E
Sbjct: 698 AHFFSE 703
Score = 209 bits (533), Expect = 8e-54
Identities = 128/429 (29%), Positives = 192/429 (44%), Gaps = 82/429 (19%)
Query: 617 ACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYV 676
ACG L G ++P +P Y + +CVW++ +I + F +L + +C YDYV
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
Query: 677 EIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSK 736
E+ G ++ L G+FCG+++PE I S + + +EF+S + KGF A +
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431
Query: 737 DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPS 796
EA C + G I SPN+PD Y
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
Query: 797 RKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDP 856
K C W I + G + L F FEIE+H CAYD+LEV DG +E S ++GR CG + PD
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
Query: 857 LVATGNKMFVRFVSDASVQRKGFQATH------------------------STECGGRLK 892
+ +T ++++++FVSD S+ + GF S +C
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577
Query: 893 AESKPRDLYSHAQFGD---------------NNYPGQVDCEWLLVSERGSRLELSFQTFE 937
E P A G YP +C W LV+ R+ L F FE
Sbjct: 578 YELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
Query: 938 VEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFH 997
E C YD+VE+ GL + + G+FCGS PE I S +++ + F +D+T++KKGF
Sbjct: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
Query: 998 IRYKSIRYP 1006
+ S + P
Sbjct: 698 AHFFSEKRP 706
>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
sapiens]
Length = 823
Score = 1116 bits (2887), Expect = 0.0
Identities = 507/696 (72%), Positives = 598/696 (85%), Gaps = 20/696 (2%)
Query: 34 DYTFDGNEEDKTETIDYKDPCKAAVFWGDIALDDEDLNIFQIDRTIDLTQNPFGNLGHTT 93
DYT+D EED +E ++YKDPCKAA F GDIALD+EDL FQ+ + +DL + HT
Sbjct: 27 DYTYDLAEEDDSEPLNYKDPCKAAAFLGDIALDEEDLRAFQVQQAVDLRR-------HTA 79
Query: 94 GGLGDHAMSKKRGALYQLIDRIRRIGFGLEQNNTVKGKVPLQFSGQNEKNRVPRAATSRT 153
++ ++ + N + ++ G ++R RAATSR
Sbjct: 80 ----------RKSSIKAAVPGNTSTPSCQSTNGQPQRGACGRWRG---RSRSRRAATSRP 126
Query: 154 ERIWPGGVIPYVIGGNFTGSQRAMFKQAMRHWEKHTCVTFIERSDEESYIVFTYRPCGCC 213
ER+WP GVIP+VIGGNFTGSQRA+F+QAMRHWEKHTCVTF+ER+DE+SYIVFTYRPCGCC
Sbjct: 127 ERVWPDGVIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCC 186
Query: 214 SYVGRRGNGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDNHVTIIRENIQPGQE 273
SYVGRRG GPQAISIGKNCDKFGIVVHELGHV+GFWHEHTRPDRD HV+I+RENIQPGQE
Sbjct: 187 SYVGRRGGGPQAISIGKNCDKFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQE 246
Query: 274 YNFLKMEPGEVNSLGERYDFDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLS 333
YNFLKMEP EV SLGE YDFDSIMHYARNTFSRG+FLDTI+P + NG++P IGQRTRLS
Sbjct: 247 YNFLKMEPQEVESLGETYDFDSIMHYARNTFSRGIFLDTIVPKYEVNGVKPPIGQRTRLS 306
Query: 334 KGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT 393
KGDIAQARKLY+CPACGETLQ+S GN SSP +PNGY ++ HC+WR+SVTPGEKI+LNFT+
Sbjct: 307 KGDIAQARKLYKCPACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTS 366
Query: 394 MDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKG 453
+DLY+S LCWYDY+EVRDG+WRK+PL GRFCG KLPE + STDSR+W+EFRSSSNWVGKG
Sbjct: 367 LDLYRSRLCWYDYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKG 426
Query: 454 FAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD 513
F AVYEAICGG+++K+ G IQSPNYPDDYRP K C+W+I VSE +HVGLTFQSFEIERHD
Sbjct: 427 FFAVYEAICGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD 486
Query: 514 NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK 573
+CAYDYLEVRDG SE+S LIGR+CGY+KP+DI+STS+ LW+KFVSDG++NKAGFA NFFK
Sbjct: 487 SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFK 546
Query: 574 EEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPG 633
E DEC++P+RGGCEQRCLNTLGSY+C+C+PGYEL PD+R CEAACGG LTKLNG+IT+PG
Sbjct: 547 EVDECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPG 606
Query: 634 WPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFC 693
WPKEYPPNKNC+WQ+VAPTQYRIS++F+FFE EGN+VCKYD+VE+ SGL+++SKLHGKFC
Sbjct: 607 WPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFC 666
Query: 694 GAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS 729
G+E PEVITSQ+NNMR+EFKSDNTVSKKGFKAHFFS
Sbjct: 667 GSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFS 702
Score = 295 bits (756), Expect = 1e-79
Identities = 154/421 (36%), Positives = 223/421 (52%), Gaps = 45/421 (10%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
CG ++ + G SP YP+ Y CVW+I+V+ + L F S ++ R C YDY+E
Sbjct: 322 CGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVE 381
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
VRDG +PL GRFCG PE I ST + LW++F S GF A +
Sbjct: 382 VRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY---------- 431
Query: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPN 641
EA CGG + K G I +P +P +Y P+
Sbjct: 432 ---------------------------------EAICGGDVKKDYGHIQSPNYPDDYRPS 458
Query: 642 KNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVI 701
K C+W++ + + + F+ FE+E ++ C YDY+E+ G S S L G++CG E P+ I
Sbjct: 459 KVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDDI 518
Query: 702 TSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDN-GGCQHECVNTMGSYMCQCRNGF 760
S + + ++F SD +++K GF +FF + DECS+ N GGC+ C+NT+GSY C C G+
Sbjct: 519 KSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPGY 578
Query: 761 VLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFE 820
L +K C EA C + +G ITSP WP +YP K C W++ A +RI L F FE
Sbjct: 579 ELAPDKRRC-EAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
Query: 821 IEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQ 880
E + C YD +EV G T S + G+ CG++ P+ + + N M V F SD +V +KGF+
Sbjct: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
Query: 881 A 881
A
Sbjct: 698 A 698
Score = 209 bits (532), Expect = 1e-53
Identities = 127/426 (29%), Positives = 191/426 (44%), Gaps = 82/426 (19%)
Query: 617 ACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYV 676
ACG L G ++P +P Y + +CVW++ +I + F +L + +C YDYV
Sbjct: 321 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYV 380
Query: 677 EIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSK 736
E+ G ++ L G+FCG+++PE I S + + +EF+S + KGF A +
Sbjct: 381 EVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY--------- 431
Query: 737 DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPS 796
EA C + G I SPN+PD Y
Sbjct: 432 ----------------------------------EAICGGDVKKDYGHIQSPNYPDDYRP 457
Query: 797 RKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDP 856
K C W I + G + L F FEIE+H CAYD+LEV DG +E S ++GR CG + PD
Sbjct: 458 SKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSESSTLIGRYCGYEKPDD 517
Query: 857 LVATGNKMFVRFVSDASVQRKGFQATH------------------------STECGGRLK 892
+ +T ++++++FVSD S+ + GF S +C
Sbjct: 518 IKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRPNRGGCEQRCLNTLGSYKCSCDPG 577
Query: 893 AESKPRDLYSHAQFGD---------------NNYPGQVDCEWLLVSERGSRLELSFQTFE 937
E P A G YP +C W LV+ R+ L F FE
Sbjct: 578 YELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFE 637
Query: 938 VEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFH 997
E C YD+VE+ GL + + G+FCGS PE I S +++ + F +D+T++KKGF
Sbjct: 638 TEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFK 697
Query: 998 IRYKSI 1003
+ S+
Sbjct: 698 AHFFSV 703
Score = 94.0 bits (232), Expect = 6e-19
Identities = 47/121 (38%), Positives = 71/121 (58%), Gaps = 1/121 (0%)
Query: 345 RCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCW 403
RC A CG L + NG+++SPG+P YP +CIW++ +I L F + + +C
Sbjct: 586 RCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCK 645
Query: 404 YDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICG 463
YD++EVR G S L G+FCG + PEV+TS + M +EF+S + KGF A + ++
Sbjct: 646 YDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLE 705
Query: 464 G 464
G
Sbjct: 706 G 706
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 320 bits (820), Expect = 4e-87
Identities = 223/744 (29%), Positives = 349/744 (46%), Gaps = 98/744 (13%)
Query: 275 NFLKMEPGEVNSLGERYD-FDSIMHYARNTFSRGMFLDTILPSRDDNGIRPAIGQRTRLS 333
NF + +S YD S M T R + I+ S + +R G +R +
Sbjct: 1551 NFTDFDLEPQDSCIMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGP-SRQN 1609
Query: 334 KGDIAQARKLYRCPACG-ETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPG-EKIVLNF 391
+G AQ R+ ACG L S +SSP FP YP+ +C W + P I L+F
Sbjct: 1610 RGFRAQFRQ-----ACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSF 1664
Query: 392 TTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVG 451
T +L +S+ C D++E+ DG +PL GR+CG +P +TS S + + F S S+
Sbjct: 1665 THFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISA 1724
Query: 452 KGFAAVYEA---ICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFE 508
GF A CGG EG SP YPD Y P ECVW I S + L+F SF+
Sbjct: 1725 GGFHTTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQ 1784
Query: 509 IERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRS-TSNTLWMKFVSDGTVNKAGF 567
+E +C+ D++E+R+G + L+GR+CG P + S +TLW++F+SDG+ + GF
Sbjct: 1785 LEDSQDCSRDFVEIREGNA-TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGF 1843
Query: 568 AANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNG 627
A F K G D + +G
Sbjct: 1844 QATFMK--------------------------------IFGNDN----------IVGTHG 1861
Query: 628 TITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESK 687
+ +P WP+ YP N N W V + + + ++E + C YD + I+ G S ++
Sbjct: 1862 KVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSIHAR 1921
Query: 688 LHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVN 747
L G +CG + E +S N++ F SD+++S KGF +F+ +G +
Sbjct: 1922 LIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFA----VDAPDG-----VLP 1971
Query: 748 TMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISAT 807
T+ C GF+ + + SP WPD Y +R +CTW I A
Sbjct: 1972 TIAPGAC---GGFL---------------RTGDAPVFLFSPGWPDSYSNRVDCTWLIQA- 2012
Query: 808 PGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVR 867
P ++L +IE H+ CAYD L + DG+ + L LCG +IP P+ +TG MF+R
Sbjct: 2013 PDSTVELNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIR 2072
Query: 868 FVSDASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGS 927
F SD+SV R GF A+ CGG L A+ R + + ++ + YP ++C W ++ + G
Sbjct: 2073 FTSDSSVTRAGFNASFHKSCGGYLHAD---RGIITSPKYPE-TYPSNLNCSWHVLVQSGL 2128
Query: 928 RLELSF-QTFEVEE-EADCGY-DYVELFDGLDSTAV------GLGRFCGSGPPEEIYSIG 978
+ + F Q F++ ++ C DY+ L +G D + G G FCGS +++
Sbjct: 2129 TIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSD 2188
Query: 979 DSVLIHFHTDDTINKKGFHIRYKS 1002
+ + + F +D + +GF I+Y++
Sbjct: 2189 NQMFVQFISDHSNEGQGFKIKYEA 2212
Score = 310 bits (793), Expect = 6e-84
Identities = 200/673 (29%), Positives = 312/673 (46%), Gaps = 110/673 (16%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L + G+ SSPGFPN YP CIW + PG I L D+ S C +D +E
Sbjct: 1391 CGGELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLE 1450
Query: 409 VRDGYWRKSPLLGRFCGDKLPE---VLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI---C 462
+ G SP + + C + PE ++ST + + I F++ + G+GF A ++A+ C
Sbjct: 1451 IYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGC 1510
Query: 463 GGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEV 522
GG + G+I SPNYP YR +C W I V ++ V L F F++E D+C Y
Sbjct: 1511 GGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY--- 1567
Query: 523 RDGTSENSPLIGRFCGYDK-PEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
DG S + R CG ++ I S+ N+L+++F S + GF A F
Sbjct: 1568 -DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQF---------- 1616
Query: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGG-LLTKLNGTITTPGWPKEYPP 640
ACGG +LT T+++P +P YP
Sbjct: 1617 ---------------------------------RQACGGHILTSSFDTVSSPRFPANYPN 1643
Query: 641 NKNCVWQVVA-PTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPE 699
N+NC W + A P I++ F FELE + C D+VEI G ++ L G++CG ++P
Sbjct: 1644 NQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHEDAPLRGRYCGTDMPH 1703
Query: 700 VITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNG 759
ITS + + + F SD+++S GF + C GG YM +
Sbjct: 1704 PITSFSSALTLRFVSDSSISAGGFHTTVTASVSAC----GGT---------FYMAE---- 1746
Query: 760 FVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEF 819
G+ SP +PD YP EC W I ++PG+R++L+F F
Sbjct: 1747 -----------------------GIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISF 1783
Query: 820 EIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIP-DPLVATGNKMFVRFVSDASVQRKG 878
++E Q+C+ D +E+ +G ++GR CGN P + G+ ++VRF+SD S G
Sbjct: 1784 QLEDSQDCSRDFVEIREGNA-TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTG 1842
Query: 879 FQATHSTECGGRLKAESKPRDLYSHAQ----FGDNNYPGQVDCEWLLVSERGSRLELSFQ 934
FQAT +K + +H + F NYP + +W + +
Sbjct: 1843 FQATF-------MKIFGNDNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRIL 1895
Query: 935 TFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKK 994
++EE +C YD + ++DG A +G +CG+ E S G+S+ HF++D +I+ K
Sbjct: 1896 EMDIEEIQNCYYDKLRIYDGPSIHARLIGAYCGT-QTESFSSTGNSLTFHFYSDSSISGK 1954
Query: 995 GFHIRYKSIRYPD 1007
GF + + ++ PD
Sbjct: 1955 GFLLEWFAVDAPD 1967
Score = 308 bits (788), Expect = 2e-83
Identities = 202/667 (30%), Positives = 309/667 (46%), Gaps = 102/667 (15%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
ACGE L ES G + SPG PN YP +C W + V P I L F T L C DY+
Sbjct: 931 ACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYNCTNDYL 990
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI-----C 462
EV D S LGR+CG +P LTS+ + + + F + S+ +GF YEAI C
Sbjct: 991 EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATAC 1048
Query: 463 GGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERH-DNCAYDYLE 521
+ + G SPN+P++Y EC+++ITV + + F +F +E N D+LE
Sbjct: 1049 LQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDFLE 1108
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
+RDG E SPL+G F G + P I S SN LW+KF SD ++GF+A +
Sbjct: 1109 IRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW---------- 1158
Query: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPN 641
CGG LT +GT +P +P Y +
Sbjct: 1159 ------------------------------DGSSTGCGGNLTTSSGTFISPNYPMPYYHS 1188
Query: 642 KNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVI 701
C W + + ++F+ F LE + C DY+ ++ G SS S L + CG E P +I
Sbjct: 1189 SECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLI 1248
Query: 702 TSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFV 761
S ++M I+ ++D +GFKA Y C N +
Sbjct: 1249 RSSGDSMFIKLRTDEGQQGRGFKA-------------------------EYRQTCENVVI 1283
Query: 762 LHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEI 821
++ G++ S +P+ Y + C W I AT G+ + F F++
Sbjct: 1284 ----------------VNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDL 1327
Query: 822 EQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQR-KGFQ 880
E H C+ D+LE++DG + +GR CG +P P T +K+ V ++D +R KGFQ
Sbjct: 1328 EHHINCSTDYLELYDGPRQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQ 1383
Query: 881 ATHST-ECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVE 939
CGG L S +S F N YP +C W + ++ GS ++L+ F+VE
Sbjct: 1384 MQWFVYGCGGEL---SGATGSFSSPGF-PNRYPPNKECIWYIRTDPGSSIQLTIHDFDVE 1439
Query: 940 EEADCGYDYVELFDGLDSTAVGLGRFCGSGPPE---EIYSIGDSVLIHFHTDDTINKKGF 996
+ C +D +E++ G D + + + C PE ++ S G+ + I F TD +IN +GF
Sbjct: 1440 YHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGF 1499
Query: 997 HIRYKSI 1003
+ ++++
Sbjct: 1500 NASWQAV 1506
Score = 308 bits (788), Expect = 2e-83
Identities = 190/666 (28%), Positives = 313/666 (46%), Gaps = 107/666 (16%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWY-DY 406
AC + + G +SP FPN YP+ CI+R++V G+ I ++FT L ++ +Y D+
Sbjct: 1047 ACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYTDF 1106
Query: 407 IEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI---CG 463
+E+RDG + KSPLLG F G LP + S +++W++F+S GF+A ++ CG
Sbjct: 1107 LEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTGCG 1166
Query: 464 GEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVR 523
G + + G SPNYP Y EC W + S L F+ F +E H NC DYL V
Sbjct: 1167 GNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVY 1226
Query: 524 DGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDR 583
DG S NS L+ + CG +KP IRS+ +++++K +D GF A +
Sbjct: 1227 DGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY------------ 1274
Query: 584 GGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKN 643
R++CE ++ + G + + G+P Y N++
Sbjct: 1275 ---------------------------RQTCENVV--IVNQTYGILESIGYPNPYSENQH 1305
Query: 644 CVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITS 703
C W + A T ++ F F+LE + C DY+E++ G + G++CG ++P ++
Sbjct: 1306 CNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDG----PRQMGRYCGVDLPPPGST 1361
Query: 704 QFNNMRIEFKSDNTVSK-KGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVL 762
+ +++ +D + KGF+ +F GC E GS+
Sbjct: 1362 TSSKLQVLLLTDGVGRREKGFQMQWFV---------YGCGGELSGATGSF---------- 1402
Query: 763 HDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIE 822
+SP +P++YP KEC W I PG I+L +F++E
Sbjct: 1403 -----------------------SSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVE 1439
Query: 823 QHQECAYDHLEVFDGETEKSPILGRLCGNKIPD---PLVATGNKMFVRFVSDASVQRKGF 879
H C +D LE++ G SP + +LC + P+ + +TGN++ +RF +D S+ +GF
Sbjct: 1440 YHSRCNFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGF 1499
Query: 880 QATHST---ECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTF 936
A+ CGG +A S H+ + Y DC W++ +R R+ L+F F
Sbjct: 1500 NASWQAVTGGCGGIFQAPSGE----IHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDF 1555
Query: 937 EVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGP-PEEIYSIGDSVLIHFHTDDTINKKG 995
++E + C + +DGL ST L R CG I S G+S+ + F + + +G
Sbjct: 1556 DLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRG 1611
Query: 996 FHIRYK 1001
F +++
Sbjct: 1612 FRAQFR 1617
Score = 291 bits (744), Expect = 3e-78
Identities = 198/674 (29%), Positives = 311/674 (46%), Gaps = 112/674 (16%)
Query: 356 SNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWR 415
++G ++SP +P YP ++ W V+V + MD+ + C+YD + + DG
Sbjct: 1859 THGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDGPSI 1918
Query: 416 KSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI-------------- 461
+ L+G +CG + E +ST + + F S S+ GKGF + A+
Sbjct: 1919 HARLIGAYCGTQT-ESFSSTGNSLTFHFYSDSSISGKGFLLEWFAVDAPDGVLPTIAPGA 1977
Query: 462 CGGEIRKNEGQIQ--SPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
CGG +R + + SP +PD Y +C W I +S V L S +IE H CAYD
Sbjct: 1978 CGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDST-VELNILSLDIESHRTCAYDS 2036
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECA 579
L +RDG + + + CG + P IRST ++++F SD +V +AGF A+F K
Sbjct: 2037 LVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHK------ 2090
Query: 580 KPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYP 639
+CGG L G IT+P +P+ YP
Sbjct: 2091 -------------------------------------SCGGYLHADRGIITSPKYPETYP 2113
Query: 640 PNKNCVWQVVAPTQYRISVKFE--FFELEGNEVCKY-DYVEIWSGLSSESKL------HG 690
N NC W V+ + I+V FE F G+ C DY+ + +G S +G
Sbjct: 2114 SNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVLRNGPDICSPPLGPPGGNG 2173
Query: 691 KFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMG 750
FCG+ + + N M ++F SD++ +GFK + + C GG
Sbjct: 2174 HFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKYEAKSLAC----GG---------- 2219
Query: 751 SYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGH 810
N ++ HD A G +TSPN P YP +C W ++A P
Sbjct: 2220 -------NVYI-----HDADSA----------GYVTSPNHPHNYPPHADCIWILAAPPET 2257
Query: 811 RIKLAFSE-FEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFV 869
RI+L F + F+IE C ++LE+ DG +PIL + CG +P ++G M++RF
Sbjct: 2258 RIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFR 2317
Query: 870 SDASVQRKGFQATHS-TECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSR 928
SD S GF+A +S +CGGR+ +S + H Y + CEW L G
Sbjct: 2318 SDNSPTHVGFKAKYSIAQCGGRVPGQSGVVESIGHPTL---PYRDNLFCEWHLQGLSGHY 2374
Query: 929 LELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTD 988
L +SF+ F ++ + C D+VE++D S + LGR+CG+ P+ I + ++ ++ F TD
Sbjct: 2375 LTISFEDFNLQNSSGCEKDFVEIWDNHTSGNI-LGRYCGNTIPDSIDTSSNTAVVRFVTD 2433
Query: 989 DTINKKGFHIRYKS 1002
++ GF +R++S
Sbjct: 2434 GSVTASGFRLRFES 2447
Score = 288 bits (738), Expect = 1e-77
Identities = 188/670 (28%), Positives = 293/670 (43%), Gaps = 109/670 (16%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG Q +G + SP +P+ Y S T C W + V +++LNFT DL C Y
Sbjct: 1510 CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSCIMAY-- 1567
Query: 409 VRDGYWRKSPLLGRFCG-DKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIR 467
DG L R CG ++L + S+ + +++ F+S + +GF A + CGG I
Sbjct: 1568 --DGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHIL 1625
Query: 468 KNE-GQIQSPNYPDDYRPMKECVWKITVSESY-HVGLTFQSFEIERHDNCAYDYLEVRDG 525
+ + SP +P +Y + C W I H+ L+F FE+ER CA D++E+ DG
Sbjct: 1626 TSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDG 1685
Query: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGG 585
E++PL GR+CG D P I S S+ L ++FVSD +++ GF
Sbjct: 1686 GHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTV-------------- 1731
Query: 586 CEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCV 645
+ +ACGG G +PG+P YPPN CV
Sbjct: 1732 --------------------------TASVSACGGTFYMAEGIFNSPGYPDIYPPNVECV 1765
Query: 646 WQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQF 705
W +V+ R+ + F F+LE ++ C D+VEI G ++ L G++CG P +S
Sbjct: 1766 WNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIV 1824
Query: 706 -NNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHD 764
+ + + F SD + S GF+A F +D
Sbjct: 1825 GHTLWVRFISDGSGSGTGFQATFMK------------------------------IFGND 1854
Query: 765 NKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQH 824
N I G + SP WP+ YP W ++ H + E +IE+
Sbjct: 1855 N------------IVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEI 1902
Query: 825 QECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGF----- 879
Q C YD L ++DG + + ++G CG + + +TGN + F SD+S+ KGF
Sbjct: 1903 QNCYYDKLRIYDGPSIHARLIGAYCGTQ-TESFSSTGNSLTFHFYSDSSISGKGFLLEWF 1961
Query: 880 ---------QATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLE 930
CGG L+ P L+S ++Y +VDC W L+ S +E
Sbjct: 1962 AVDAPDGVLPTIAPGACGGFLRTGDAPVFLFSPG--WPDSYSNRVDCTW-LIQAPDSTVE 2018
Query: 931 LSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDT 990
L+ + ++E C YD + + DG ++ A L CG P I S G+ + I F +D +
Sbjct: 2019 LNILSLDIESHRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSS 2078
Query: 991 INKKGFHIRY 1000
+ + GF+ +
Sbjct: 2079 VTRAGFNASF 2088
Score = 288 bits (736), Expect = 2e-77
Identities = 192/670 (28%), Positives = 300/670 (44%), Gaps = 97/670 (14%)
Query: 338 AQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLY 397
A R +Y+ ACG+ L G + SP FPN YP C W + + I+LNFT ++
Sbjct: 807 ASFRAVYQV-ACGDELT-GEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIG 864
Query: 398 KSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAV 457
S+ C DY+E+ SP ++CG +P +TS + +++ F SS+ GF A
Sbjct: 865 SSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924
Query: 458 YEA---ICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDN 514
+ A CG + ++ G IQSP +P+ Y C W I V ++ + L F++F +E H N
Sbjct: 925 FSAEDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEFHYN 984
Query: 515 CAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKE 574
C DYLEV D SE S +GR+CG P + S+ N+L + FV+D + GF N+
Sbjct: 985 CTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY--- 1039
Query: 575 EDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGW 634
+ S AC T GT T+P +
Sbjct: 1040 -----------------------------------EAISAATACLQDYTDDLGTFTSPNF 1064
Query: 635 PKEYPPNKNCVWQVVAPTQYRISVKFEFFELE---GNEVCKYDYVEIWSGLSSESKLHGK 691
P YP N C++++ T I+V F F LE GN D++EI G +S L G
Sbjct: 1065 PNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNYYT--DFLEIRDGGYEKSPLLGI 1122
Query: 692 FCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGS 751
F G+ +P I S N + ++FKSD ++ GF A++
Sbjct: 1123 FYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW------------------------ 1158
Query: 752 YMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHR 811
D C + + SG SPN+P Y EC W + ++ G
Sbjct: 1159 ----------------DGSSTGCGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSA 1202
Query: 812 IKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSD 871
+L F +F +E H C D+L V+DG + S +L +LCG++ P + ++G+ MF++ +D
Sbjct: 1203 FELEFKDFHLEHHPNCTLDYLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTD 1262
Query: 872 ASVQRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLEL 931
Q +GF+A + C + L S N Y C W + + G+ +
Sbjct: 1263 EGQQGRGFKAEYRQTCENVVIVNQTYGILESIGY--PNPYSENQHCNWTIRATTGNTVNY 1320
Query: 932 SFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDT- 990
+F F++E +C DY+EL+DG +GR+CG P + + + TD
Sbjct: 1321 TFLAFDLEHHINCSTDYLELYDGPRQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVG 1376
Query: 991 INKKGFHIRY 1000
+KGF +++
Sbjct: 1377 RREKGFQMQW 1386
Score = 286 bits (731), Expect = 9e-77
Identities = 190/664 (28%), Positives = 305/664 (45%), Gaps = 110/664 (16%)
Query: 353 LQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDG 412
+ ++ G L S G+PN Y HC W + T G + F DL C DY+E+ DG
Sbjct: 1284 VNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYLELYDG 1343
Query: 413 YWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVG---KGFAAVYEAI-CGGEIRK 468
+ +GR+CG LP ++T S++ + + VG KGF + CGGE+
Sbjct: 1344 PRQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDG--VGRREKGFQMQWFVYGCGGELSG 1397
Query: 469 NEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSE 528
G SP +P+ Y P KEC+W I + LT F++E H C +D LE+ G
Sbjct: 1398 ATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDF 1457
Query: 529 NSPLIGRFCGYDKPED---IRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGG 585
+SP I + C PE+ + ST N L ++F +D ++N GF A++
Sbjct: 1458 HSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASW-------------- 1503
Query: 586 CEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCV 645
++ CGG+ +G I +P +P Y N +C
Sbjct: 1504 --------------------------QAVTGGCGGIFQAPSGEIHSPNYPSPYRSNTDCS 1537
Query: 646 WQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAE-VPEVITSQ 704
W + +R+ + F F+LE + C + + GLSS + CG E + I S
Sbjct: 1538 WVIRVDRNHRVLLNFTDFDLEPQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSS 1593
Query: 705 FNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHD 764
N++ + F+S + +GF+A F Q G +L
Sbjct: 1594 GNSLFLRFQSGPSRQNRGFRAQFR--------------------------QACGGHILT- 1626
Query: 765 NKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPG-HRIKLAFSEFEIEQ 823
S ++SP +P YP+ + C+W I A P + I L+F+ FE+E+
Sbjct: 1627 ---------------SSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELER 1671
Query: 824 HQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
CA D +E+ DG E +P+ GR CG +P P+ + + + +RFVSD+S+ GF T
Sbjct: 1672 STTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGFHTTV 1731
Query: 884 S---TECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEE 940
+ + CGG +++ + D YP V+C W +VS G+RL+LSF +F++E+
Sbjct: 1732 TASVSACGGTF---YMAEGIFNSPGYPD-IYPPNVECVWNIVSSPGNRLQLSFISFQLED 1787
Query: 941 EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSI-GDSVLIHFHTDDTINKKGFHIR 999
DC D+VE+ +G ++T +GR+CG+ P SI G ++ + F +D + + GF
Sbjct: 1788 SQDCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQAT 1846
Query: 1000 YKSI 1003
+ I
Sbjct: 1847 FMKI 1850
Score = 280 bits (715), Expect = 6e-75
Identities = 191/679 (28%), Positives = 304/679 (44%), Gaps = 111/679 (16%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT---MDLYKSSLCWY 404
+CG L G ++SP +P YPS +C W V V G I ++F + SS
Sbjct: 2091 SCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQG 2150
Query: 405 DYIEVRDGYWRKSPLLG------RFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
DY+ +R+G SP LG FCG L ++D++M+++F S + G+GF Y
Sbjct: 2151 DYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY 2210
Query: 459 EA---ICGGEIRKNE----GQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS-FEIE 510
EA CGG + ++ G + SPN+P +Y P +C+W + + L F+ F+IE
Sbjct: 2211 EAKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIE 2270
Query: 511 RHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAAN 570
NC +YLE+RDG ++P++ +FCG P S+ ++++F SD + GF A
Sbjct: 2271 VTPNCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAK 2330
Query: 571 FFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTIT 630
+ A CGG + +G +
Sbjct: 2331 Y------------------------------------------SIAQCGGRVPGQSGVVE 2348
Query: 631 TPGWPK-EYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLH 689
+ G P Y N C W + + + +++ FE F L+ + C+ D+VEIW +S + L
Sbjct: 2349 SIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNIL- 2407
Query: 690 GKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTM 749
G++CG +P+ I + N + F +D +V+ GF+ F S +EC D
Sbjct: 2408 GRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEECGGD------------ 2455
Query: 750 GSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPG 809
+ G TSPN+P+ P + C W I+A G
Sbjct: 2456 ----------------------------LQGSIGTFTSPNYPNPNPHGRICEWRITAPEG 2487
Query: 810 HRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGN-KIPDPLVATGNKMFVRF 868
RI L F+ + H C +H+ VF+G SP L +LC + + + + ++GN M V F
Sbjct: 2488 RRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIF 2547
Query: 869 VSDASVQRKGFQATHSTE----CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLL--V 922
+D S GF A++++ CGG L + + S G NY ++CEW L
Sbjct: 2548 FTDGSRPYGGFTASYTSSEDAVCGGSL-PNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNP 2606
Query: 923 SERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDS-V 981
++ S + + F+ F +E DC +D +E G D+ + R CG P I S V
Sbjct: 2607 NQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLCGPSKPTLPLVIPYSQV 2665
Query: 982 LIHFHTDDTINKKGFHIRY 1000
IHF T++ + GFH +Y
Sbjct: 2666 WIHFVTNERVEHIGFHAKY 2684
Score = 268 bits (684), Expect = 3e-71
Identities = 189/681 (27%), Positives = 295/681 (43%), Gaps = 119/681 (17%)
Query: 348 ACGETLQESNGN--LSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405
ACG L+ + L SPG+P+ Y + C W + P + LN ++D+ C YD
Sbjct: 1977 ACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIESHRTCAYD 2035
Query: 406 YIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGE 465
+ +RDG + L CG ++P + ST M+I F S S+ GF A + CGG
Sbjct: 2036 SLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGGY 2095
Query: 466 IRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTF-QSFEIERHDNCAY--DYLEV 522
+ + G I SP YP+ Y C W + V + + F Q F+I D+ DYL +
Sbjct: 2096 LHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQGDYLVL 2155
Query: 523 RDGTSENSPLI------GRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEED 576
R+G SP + G FCG + ++ N ++++F+SD + GF +
Sbjct: 2156 RNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIKY----- 2210
Query: 577 ECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLL----TKLNGTITTP 632
E + L ACGG + G +T+P
Sbjct: 2211 ----------EAKSL-------------------------ACGGNVYIHDADSAGYVTSP 2235
Query: 633 GWPKEYPPNKNCVWQVVAPTQYRISVKFE-FFELEGNEVCKYDYVEIWSGLSSESKLHGK 691
P YPP+ +C+W + AP + RI ++FE F++E C +Y+E+ G+ S++ + K
Sbjct: 2236 NHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSDAPILSK 2295
Query: 692 FCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGS 751
FCG +P S M + F+SDN+ + GFKA +
Sbjct: 2296 FCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKY------------------------ 2331
Query: 752 YMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPD-KYPSRKECTWEISATPGH 810
A+C ++ SG++ S P Y C W + GH
Sbjct: 2332 ------------------SIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGH 2373
Query: 811 RIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVS 870
+ ++F +F ++ C D +E++D T + ILGR CGN IPD + + N VRFV+
Sbjct: 2374 YLTISFEDFNLQNSSGCEKDFVEIWDNHTSGN-ILGRYCGNTIPDSIDTSSNTAVVRFVT 2432
Query: 871 DASVQRKGFQATHST---ECGGRLKAESKPRDLYSHAQFGDNNYP-----GQVDCEWLLV 922
D SV GF+ + ECGG L+ S F NYP G++ CEW +
Sbjct: 2433 DGSVTASGFRLRFESSMEECGGDLQG--------SIGTFTSPNYPNPNPHGRI-CEWRIT 2483
Query: 923 SERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGS-GPPEEIYSIGDSV 981
+ G R+ L F + C ++V +F+G+ S + L + C S EI S G+++
Sbjct: 2484 APEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTM 2543
Query: 982 LIHFHTDDTINKKGFHIRYKS 1002
+ F TD + GF Y S
Sbjct: 2544 KVIFFTDGSRPYGGFTASYTS 2564
Score = 267 bits (682), Expect = 4e-71
Identities = 185/680 (27%), Positives = 285/680 (41%), Gaps = 102/680 (15%)
Query: 330 TRLSKGDIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVL 389
TRL G + Q + CGE+L NG+ S GY +C W + G+ + +
Sbjct: 459 TRLWTGALCQVPQ----QVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRI 514
Query: 390 NFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNW 449
FT L C +++++V DG + LGRFCG LP L S+D+ ++ S
Sbjct: 515 TFTFFRLESMDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLR 574
Query: 450 VGKGFAAVYEAI---CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS 506
G+GF +E CGG + G I+SP YP +Y P ++CVW + S V TF +
Sbjct: 575 NGRGFTVRWETQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGT 634
Query: 507 FEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAG 566
+E HD+C DYLE+RDG PL+G+FC +++T + F SD ++ G
Sbjct: 635 LSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQG 694
Query: 567 FAANFFKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLN 626
F + + CGG T
Sbjct: 695 FHITYLTSPS--------------------------------------DLRCGGNYTDPE 716
Query: 627 GTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSES 686
G + P + + CV+ + P +I + F EL+ +Y+E+ G
Sbjct: 717 GELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQNYIEVRDG----E 772
Query: 687 KLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECV 746
L GK CG I S N++ I FK D +V K F+A +
Sbjct: 773 TLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVY------------------- 813
Query: 747 NTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISA 806
+ C ++ + G+I SP +P+ YP + C W I
Sbjct: 814 ------------------------QVACGDEL-TGEGVIRSPFFPNVYPGERTCRWTIHQ 848
Query: 807 TPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFV 866
I L F+ FEI C D++E+ SP + CG IP + + N ++V
Sbjct: 849 PQSQVILLNFTVFEIGSSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYV 908
Query: 867 RFVSDASVQRKGFQATHSTE---CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVS 923
FV +S + GF A S E CG L + H N YP ++C W ++
Sbjct: 909 TFVKSSSTENHGFMAKFSAEDLACGEILTESTGTIQSPGH----PNVYPHGINCTWHILV 964
Query: 924 ERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
+ + L F+TF +E +C DY+E++D T+ LGR+CG P + S G+S+++
Sbjct: 965 QPNHLIHLMFETFHLEFHYNCTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLML 1022
Query: 984 HFHTDDTINKKGFHIRYKSI 1003
F TD + +GF I Y++I
Sbjct: 1023 VFVTDSDLAYEGFLINYEAI 1042
Score = 265 bits (677), Expect = 2e-70
Identities = 184/679 (27%), Positives = 304/679 (44%), Gaps = 118/679 (17%)
Query: 348 ACGETLQ----ESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT-MDLYKSSLC 402
ACG + +S G ++SP P+ YP + CIW ++ P +I L F D+ + C
Sbjct: 2216 ACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNC 2275
Query: 403 WYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYE-AI 461
+Y+E+RDG +P+L +FCG LP S+ M++ FRS ++ GF A Y A
Sbjct: 2276 TSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIAQ 2335
Query: 462 CGGEIRKNEGQIQSPNYPD-DYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYL 520
CGG + G ++S +P YR C W + +++ ++F+ F ++ C D++
Sbjct: 2336 CGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFV 2395
Query: 521 EVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK 580
E+ D + + ++GR+CG P+ I ++SNT ++FV+DG+V +GF F +E
Sbjct: 2396 EIWDNHTSGN-ILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSMEE--- 2451
Query: 581 PDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPP 640
CGG L GT T+P +P P
Sbjct: 2452 -------------------------------------CGGDLQGSIGTFTSPNYPNPNPH 2474
Query: 641 NKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGA-EVPE 699
+ C W++ AP RI++ F L + C ++V +++G+ S S K C + V
Sbjct: 2475 GRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEKLCSSVNVSN 2534
Query: 700 VITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNG 759
I S N M++ F +D + GF A + S +D C NT
Sbjct: 2535 EIKSSGNTMKVIFFTDGSRPYGGFTASYTSSEDAV------CGGSLPNT----------- 2577
Query: 760 FVLHDNKHDCKEAECEQKIHSPSGLITSPNWPD--KYPSRKECTWEIS--ATPGHRIKLA 815
P G TSP + Y C W +S I +
Sbjct: 2578 ---------------------PEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIH 2616
Query: 816 FSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPD-PLVATGNKMFVRFVSDASV 874
F +F +E HQ+C +D LE G+ + P++ RLCG P PLV +++++ FV++ V
Sbjct: 2617 FEDFYLESHQDCQFDVLEFRVGDAD-GPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERV 2675
Query: 875 QRKGFQATHS-TECGGRLKAESKPRDLYSHAQFGDN------NYPGQVD----CEWLLVS 923
+ GF A +S T+CGG Q GD+ NYP D C LL +
Sbjct: 2676 EHIGFHAKYSFTDCGG--------------IQIGDSGVITSPNYPNAYDSLTHCSSLLEA 2721
Query: 924 ERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
+G + L+F F++E C +D V + +G + +G++CG+ P I S + +++
Sbjct: 2722 PQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVV 2781
Query: 984 HFHTDDTINKKGFHIRYKS 1002
F++D ++ GF+ + +
Sbjct: 2782 TFNSDHSLQGGGFYATWNT 2800
Score = 259 bits (663), Expect = 7e-69
Identities = 175/677 (25%), Positives = 292/677 (43%), Gaps = 103/677 (15%)
Query: 344 YRCPACGETLQESNGNLSSPGFPNG-YPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLC 402
YR +CG S+G ++SP + YP+ HC++ ++V+ + I L F+ D+ S+ C
Sbjct: 3032 YRIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSC 3091
Query: 403 WYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI- 461
+DY+ + DG PLLG+FCG K P + S+++ M + F++ S KG+ +
Sbjct: 3092 SHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTL 3151
Query: 462 -----CGGEIRKNEGQIQSPNYPDD--YRPMKECVWKITVSESYHVGLTFQSFEIER--- 511
CGG + + SP+ + Y CVW I + + LTF +F +E
Sbjct: 3152 GPQQGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAAST 3211
Query: 512 HDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571
C YDY+++ DG SEN+ L G FCG P S+ N L ++F+SD T+ + GF A +
Sbjct: 3212 RQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY 3271
Query: 572 FKEEDECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITT 631
+ C G+Y P I++
Sbjct: 3272 TIMDMPCG---------------GTYNATWTPQ-----------------------NISS 3293
Query: 632 PGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGK 691
P P C W + +P ++ + +L + C +Y+++ +
Sbjct: 3294 PNSSDPDVPFSICTWVIDSPPHQQVKITVWALQLTSQD-CTQNYLQLQDSPQGHGNSRFQ 3352
Query: 692 FCG--AEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTM 749
FCG A V S + + FKS V++ N+
Sbjct: 3353 FCGRNASAVPVFYSSMSTAMVIFKS-GVVNR--------------------------NSR 3385
Query: 750 GSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPG 809
S+ Q A+C + H G + SP WPD Y + K+CT ++A
Sbjct: 3386 MSFTYQI---------------ADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQN 3430
Query: 810 HRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFV 869
H I L F IE EC D LEV +G SP+LG+ CG +P+P+ + N++++RF
Sbjct: 3431 HTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFK 3490
Query: 870 SDASVQRKGFQ---ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERG 926
SD+ +G++ + + CGG L + R ++ + YP CEW+LV+ G
Sbjct: 3491 SDSVTSDRGYEIIWTSSPSGCGGTLYGD---RGSFTSPGY-PGTYPNNTYCEWVLVAPAG 3546
Query: 927 SRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPP-EEIYSIGDSVLIHF 985
+ ++F +++ DC +Y+ L+DG ++++ G +CG + + V I F
Sbjct: 3547 RLVTINFYFISIDDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKF 3606
Query: 986 HTDDTINKKGFHIRYKS 1002
H D F + + S
Sbjct: 3607 HADYARRPSAFRLTWDS 3623
Score = 241 bits (615), Expect = 3e-63
Identities = 173/663 (26%), Positives = 290/663 (43%), Gaps = 104/663 (15%)
Query: 344 YRCPACGETLQESNGNLSSPGFPN-GYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLC 402
Y CG + +G + S G P Y C W + G + ++F +L SS C
Sbjct: 2331 YSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGC 2390
Query: 403 WYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI- 461
D++E+ D + +LGR+CG+ +P+ + ++ + + F + + GF +E+
Sbjct: 2391 EKDFVEIWDNH-TSGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSM 2449
Query: 462 --CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
CGG+++ + G SPNYP+ + C W+IT E + L F + + H +C ++
Sbjct: 2450 EECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEH 2509
Query: 520 LEVRDGTSENSPLIGRFC-GYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
+ V +G NSP + + C + +I+S+ NT+ + F +DG+ GF A++ ED
Sbjct: 2510 VIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASYTSSED-- 2567
Query: 579 AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKL-NGTITTPGWP-- 635
A CGG L G T+PG+
Sbjct: 2568 -------------------------------------AVCGGSLPNTPEGNFTSPGYDGV 2590
Query: 636 KEYPPNKNCVWQVVAPTQ--YRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFC 693
+ Y N NC W + P Q IS+ FE F LE ++ C++D +E G ++ L + C
Sbjct: 2591 RNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQDCQFDVLEFRVG-DADGPLMWRLC 2649
Query: 694 GAEVPEV-ITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSY 752
G P + + ++ + I F ++ V GF A + D GG Q
Sbjct: 2650 GPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKY------SFTDCGGIQ---------- 2693
Query: 753 MCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRI 812
SG+ITSPN+P+ Y S C+ + A GH I
Sbjct: 2694 --------------------------IGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTI 2727
Query: 813 KLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDA 872
L FS+F+IE H CA+D + V +G + +SPI+G+ CGN P + + N++ V F SD
Sbjct: 2728 TLTFSDFDIEPHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDH 2787
Query: 873 SVQRKGFQATHSTE---CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRL 929
S+Q GF AT +T+ CGG +++ + N+P C W ++ + L
Sbjct: 2788 SLQGGGFYATWNTQTLGCGGIFHSDNGT----IRSPHWPQNFPENSRCSWTAITHKSKHL 2843
Query: 930 ELSFQTFEVEEEAD--CGYDYVELFDGLDSTAVG-LGRFCGSGPPEEIYSIGDSVLIHFH 986
E+SF + D C +V+++ G + L CG+ P + + ++ F
Sbjct: 2844 EISFDNNFLIPSGDGQCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQ 2903
Query: 987 TDD 989
+ +
Sbjct: 2904 SQE 2906
Score = 240 bits (612), Expect = 6e-63
Identities = 175/683 (25%), Positives = 288/683 (42%), Gaps = 109/683 (15%)
Query: 344 YRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCW 403
Y CG +G ++SP +PN Y S THC + G I L F+ D+ + C
Sbjct: 2684 YSFTDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCA 2743
Query: 404 YDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI-- 461
+D + VR+G +SP++G++CG+ P + S +++ + F S + G GF A +
Sbjct: 2744 WDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWNTQTL 2803
Query: 462 -CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS-FEIERHDN-CAYD 518
CGG + G I+SP++P ++ C W +S H+ ++F + F I D C
Sbjct: 2804 GCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNS 2863
Query: 519 YLEVRDGTSE-NSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDE 577
+++V GT E + L+ CG P + + SNT F S + GF+A+F
Sbjct: 2864 FVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQ-GFSASFVSR--- 2919
Query: 578 CAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKE 637
CG T +G I +P +PK+
Sbjct: 2920 ----------------------------------------CGSNFTGPSGYIISPNYPKQ 2939
Query: 638 YPPNKNCVWQVVAPTQYRISVKFEFFELEGNEV----CKYDYVEIWSGLSSESKLHGKFC 693
Y N NC + + A + + F F LE C D V I G S S C
Sbjct: 2940 YDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHIIRGYSVMSTPFATVC 2999
Query: 694 GAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYM 753
G E+P +T + + F S+ ++ GFK +
Sbjct: 3000 GDEMPAPLTIA-GPVLLNFYSNEQITDFGFKFSY-------------------------- 3032
Query: 754 CQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWP-DKYPSRKECTWEISATPGHRI 812
+ C + SG+ITSP + YP+ C + I+ + I
Sbjct: 3033 ----------------RIISCGGVFNFSSGIITSPAYSYADYPNDMHCLYTITVSDDKVI 3076
Query: 813 KLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDA 872
+L FS+F++ C++D+L ++DG P+LG+ CG+K P + ++ N M + F +D+
Sbjct: 3077 ELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDS 3136
Query: 873 SVQRKGFQATHSTE------CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERG 926
KG++ + CGG L + S + Y ++C W++++
Sbjct: 3137 FQTAKGWKMSFRQTLGPQQGCGGYLTGSNNT--FASPDSDSNGMYDKNLNCVWIIIAPVN 3194
Query: 927 SRLELSFQTFEVEEEAD---CGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
+ L+F TF +E + C YDYV+L+DG A G FCGS P S G+ + +
Sbjct: 3195 KVIHLTFNTFALEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTV 3254
Query: 984 HFHTDDTINKKGFHIRYKSIRYP 1006
F +D T+ ++GF+ Y + P
Sbjct: 3255 QFISDLTLEREGFNATYTIMDMP 3277
Score = 206 bits (523), Expect = 1e-52
Identities = 155/633 (24%), Positives = 266/633 (42%), Gaps = 96/633 (15%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSS--LCWYDY 406
CG NG + SP +P +P + C W + + ++F L S C +
Sbjct: 2805 CGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSF 2864
Query: 407 IEVRDGYWR-KSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGE 465
++V G LL CG+ P + + + F+S +GF+A + + CG
Sbjct: 2865 VKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEA-PAQGFSASFVSRCGSN 2923
Query: 466 IRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD----NCAYDYLE 521
G I SPNYP Y C + I + V LTF SF +E +C D +
Sbjct: 2924 FTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVH 2983
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
+ G S S CG + P + L + F S+ + GF ++
Sbjct: 2984 IIRGYSVMSTPFATVCGDEMPAPLTIAGPVL-LNFYSNEQITDFGFKFSY---------- 3032
Query: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWP-KEYPP 640
R ++ CGG+ +G IT+P + +YP
Sbjct: 3033 -------RIIS-------------------------CGGVFNFSSGIITSPAYSYADYPN 3060
Query: 641 NKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEV 700
+ +C++ + I +KF F++ + C +DY+ I+ G ++ L GKFCG++ P
Sbjct: 3061 DMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANTSDPLLGKFCGSKRPPN 3120
Query: 701 ITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGF 760
+ S N+M + FK+D+ + KG+K F + G Q C G Y+ N F
Sbjct: 3121 VKSSNNSMLLVFKTDSFQTAKGWKMSF--------RQTLGPQQGC----GGYLTGSNNTF 3168
Query: 761 VLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFE 820
D+ + Y C W I A I L F+ F
Sbjct: 3169 ASPDSDSN-----------------------GMYDKNLNCVWIIIAPVNKVIHLTFNTFA 3205
Query: 821 IEQ---HQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRK 877
+E Q C YD+++++DG++E + + G CG+ +P P +++GN + V+F+SD +++R+
Sbjct: 3206 LEAASTRQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLERE 3265
Query: 878 GFQATHS---TECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQ 934
GF AT++ CGG A P+++ S D + P + C W++ S +++++
Sbjct: 3266 GFNATYTIMDMPCGGTYNATWTPQNI-SSPNSSDPDVPFSI-CTWVIDSPPHQQVKITVW 3323
Query: 935 TFEVEEEADCGYDYVELFDGLDSTAVGLGRFCG 967
++ + DC +Y++L D +FCG
Sbjct: 3324 ALQLTSQ-DCTQNYLQLQDSPQGHGNSRFQFCG 3355
Score = 124 bits (312), Expect = 3e-28
Identities = 117/461 (25%), Positives = 186/461 (40%), Gaps = 82/461 (17%)
Query: 566 GFAANFFKEED--ECAKPDRGGCEQ----RCLNTLGSYQC-ACEPGYELGPDRRSC---- 614
G+ N + ED EC + + GGC C+NT GS C AC PGY+ D R C
Sbjct: 295 GWQGNGYICEDINEC-EINNGGCSVAPPVECVNTPGSSHCQACPPGYQ--GDGRVCTLTD 351
Query: 615 -----------EAACGGLLTKLNGTITTPGWPKE-YPPNKNCVWQVVAPTQYRISVKFEF 662
+A+C L L PG+ Y PN CV Q+ + +
Sbjct: 352 ICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPN-GCV-QLSNICLSHPCLNGQC 409
Query: 663 FELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKG 722
+ CK D W+G++ C + E +++
Sbjct: 410 IDTVSGYFCKCD--SGWTGVN---------CTENINECLSNP------------------ 440
Query: 723 FKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPS 782
C NGG CV+ + S+ C+C + + C + + +
Sbjct: 441 -----------CL--NGGT---CVDGVDSFSCECTRLWT--GALCQVPQQVCGESLSGIN 482
Query: 783 GLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKS 842
G + + Y C W I G +++ F+ F +E C ++ L+V+DG++ +
Sbjct: 483 GSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSA 542
Query: 843 PILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQA---THSTECGGRLKAESKPRD 899
LGR CG+ +P L+++ N ++ S+ +GF T ECGG L + P
Sbjct: 543 FQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQQPECGGIL---TGPYG 599
Query: 900 LYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTA 959
+ NYP DC W++V+ + +F T +E DC DY+E+ DG
Sbjct: 600 SIKSPGY-PGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDGPLYQD 658
Query: 960 VGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
LG+FC + + + G IHFH+D I+ +GFHI Y
Sbjct: 659 PLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITY 699
Score = 33.5 bits (75), Expect = 1.0
Identities = 28/102 (27%), Positives = 40/102 (39%), Gaps = 27/102 (26%)
Query: 729 SDKDECSKDNG---GCQH--ECVNTMGSYMCQC---RNGFVLHDNKHDCKEAECEQKIHS 780
+D +EC +G CQ+ CVNTMGSY C C G DC+ + +H
Sbjct: 169 ADVNECEIYSGTPLSCQNGGTCVNTMGSYSCHCPPETYGPQCASKYDDCEGGSVARCVHG 228
Query: 781 -------------------PSGLITSPNWPDKYPSRKECTWE 803
+G + SPN P R EC+++
Sbjct: 229 ICEDLMREQAGEPKYSCVCDAGWMFSPNSPACTLDRDECSFQ 270
Score = 33.5 bits (75), Expect = 1.0
Identities = 20/50 (40%), Positives = 27/50 (54%), Gaps = 6/50 (12%)
Query: 730 DKDECSKDNGGCQH--ECVNTMGSYMC-QCRNGFVLHDNKHDCKEA-ECE 775
D+DECS G C +C NT GS+ C C G+ N + C++ ECE
Sbjct: 263 DRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGW--QGNGYICEDINECE 310
>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
Length = 449
Score = 221 bits (562), Expect = 4e-57
Identities = 127/435 (29%), Positives = 201/435 (46%), Gaps = 94/435 (21%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
CGG + G SPN+P Y EC W I V+E V LTF +F++E HD C++D+LE
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
Query: 522 VRDGTS-ENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK 580
+ +G S + L+GRFCG P S+ + + + F SD V GF+A + K+
Sbjct: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKD------ 143
Query: 581 PDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPP 640
CGG+LT L+G +T+P +P YP
Sbjct: 144 ------------------------------------VCGGVLTGLSGVLTSPEYPNNYPN 167
Query: 641 NKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEV 700
+ C W + A + + F F++EGNE C YDYV + G H +CG+ P
Sbjct: 168 SMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGPGPTRGHH--YCGSTRPPT 225
Query: 701 ITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVNTMGSYMCQCRNGF 760
+ S + +++ FKSD + +GFKA++FS
Sbjct: 226 LVSLGHELQVVFKSDFNIGGRGFKAYYFS------------------------------- 254
Query: 761 VLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFE 820
EC++ + G +SP +P YP+ C W I PG+++K+ F + +
Sbjct: 255 -----------GECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLD 303
Query: 821 IEQHQE----CAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQR 876
+E+ C +DHL FDG +E++P+LG CG+ +P P+ ++ N++ + +D S R
Sbjct: 304 LEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTR 363
Query: 877 KGFQATHSTECGGRL 891
+GF + GG+L
Sbjct: 364 RGFSVAY---IGGQL 375
Score = 192 bits (487), Expect = 2e-48
Identities = 115/393 (29%), Positives = 174/393 (44%), Gaps = 52/393 (13%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L +GN SSP FP YP T C W + V G ++L F DL C +D++E
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
Query: 409 VRDGYW-RKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA-ICGGEI 466
+ +G K LLGRFCG P TS+ M + F S + GF+A Y+ +CGG +
Sbjct: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGVL 149
Query: 467 RKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGT 526
G + SP YP++Y EC W I + HV L F F++E ++ C YDY+ V G
Sbjct: 150 TGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGP 209
Query: 527 SENSPLIG-RFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGG 585
P G +CG +P + S + L + F SD + GF A +F E
Sbjct: 210 ---GPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE---------- 256
Query: 586 CEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCV 645
C + + G ++P +P YP N C
Sbjct: 257 --------------------------------CQEVYMAMRGNFSSPQYPSSYPNNIRCH 284
Query: 646 WQVVAPTQYRISVKFEFFELEG----NEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVI 701
W + P Y++ V F +LE + C +D++ + G S E+ L G +CG +P +
Sbjct: 285 WTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHLPPPV 344
Query: 702 TSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
TS N + + +D + +++GF + + C
Sbjct: 345 TSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLGC 377
Score = 186 bits (473), Expect = 7e-47
Identities = 117/390 (30%), Positives = 190/390 (48%), Gaps = 56/390 (14%)
Query: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677
CGG+L+ +G ++P +P+ YP N C W +V + + F F+LE ++ C +D++E
Sbjct: 30 CGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFLE 89
Query: 678 IWSGLSSES-KLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSK 736
I++G S + L G+FCG P TS ++ M + F SD V+ GF A + KD C
Sbjct: 90 IYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGY--QKDVC-- 145
Query: 737 DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPS 796
GG + SG++TSP +P+ YP+
Sbjct: 146 --GGV------------------------------------LTGLSGVLTSPEYPNNYPN 167
Query: 797 RKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGR-LCGNKIPD 855
EC W I A +KL F +F++E ++EC YD++ V G P G CG+ P
Sbjct: 168 SMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVAVLGGP---GPTRGHHYCGSTRPP 224
Query: 856 PLVATGNKMFVRFVSDASVQRKGFQATH-STECGGRLKAESKPRDLYSHAQFGDNNYPGQ 914
LV+ G+++ V F SD ++ +GF+A + S EC A R +S Q+ ++YP
Sbjct: 225 TLVSLGHELQVVFKSDFNIGGRGFKAYYFSGECQEVYMAM---RGNFSSPQY-PSSYPNN 280
Query: 915 VDCEWLLVSERGSRLELSFQTFEVEEEAD----CGYDYVELFDGLDSTAVGLGRFCGSGP 970
+ C W + G ++++ F ++EE C +D++ FDG A LG +CG
Sbjct: 281 IRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDFDHLAAFDGASEEAPLLGNWCGHHL 340
Query: 971 PEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
P + S + +L+ HTD + ++GF + Y
Sbjct: 341 PPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370
Score = 139 bits (351), Expect = 1e-32
Identities = 78/232 (33%), Positives = 122/232 (52%), Gaps = 8/232 (3%)
Query: 773 ECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
+C + +PSG +SPN+P YP EC+W I G + L F F++E H C++D L
Sbjct: 29 KCGGVLSAPSGNFSSPNFPRLYPYNTECSWLIVVAEGSSVLLTFHAFDLEYHDTCSFDFL 88
Query: 833 EVFDGET-EKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTE-CGGR 890
E+++G + +K +LGR CG P P ++ + M V F SD V GF A + + CGG
Sbjct: 89 EIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFSAGYQKDVCGGV 148
Query: 891 LKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVE 950
L S + + ++ NNYP ++C W++ + + ++L F F+VE +C YDYV
Sbjct: 149 LTGLS---GVLTSPEY-PNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECTYDYVA 204
Query: 951 LFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
+ G T +CGS P + S+G + + F +D I +GF Y S
Sbjct: 205 VLGGPGPTRG--HHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFS 254
Score = 122 bits (307), Expect = 1e-27
Identities = 72/248 (29%), Positives = 108/248 (43%), Gaps = 9/248 (3%)
Query: 344 YRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCW 403
Y+ CG L +G L+SP +PN YP+ C W + + L F + + C
Sbjct: 140 YQKDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQVEGNEECT 199
Query: 404 YDYIEVRDGYWRKSPLLGR-FCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY-EAI 461
YDY+ V G P G +CG P L S + + F+S N G+GF A Y
Sbjct: 200 YDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYFSGE 256
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDN----CAY 517
C G SP YP Y C W I + Y V + F ++E ++ C +
Sbjct: 257 CQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLEEPNSLTKTCDF 316
Query: 518 DYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDE 577
D+L DG SE +PL+G +CG+ P + S+ N L + +D + + GF+ + +
Sbjct: 317 DHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAYIGGQLG 376
Query: 578 CAKPDRGG 585
C G
Sbjct: 377 CGSGSTEG 384
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sapiens]
Length = 3667
Score = 218 bits (555), Expect = 2e-56
Identities = 201/831 (24%), Positives = 329/831 (39%), Gaps = 191/831 (22%)
Query: 341 RKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIV-LNFTTMDLYKS 399
R + + CG LQ +G +SP FP Y S C+W ++ K++ +NF DL
Sbjct: 500 RPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE-- 557
Query: 400 SLCWYDYIEVRDGYWRKSP--LLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAV 457
YD + + DG P +L G +P+++ S S+MW+ ++ + GF
Sbjct: 558 --IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVN 615
Query: 458 YEAI----CGGE------IRKNEG------------------------------------ 471
Y+ I CG IR+ +G
Sbjct: 616 YKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIP 675
Query: 472 ---------------QIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCA 516
+ SP+YP+ Y C+W I + L+F F++E
Sbjct: 676 ICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ---- 731
Query: 517 YDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK-EE 575
+D+L V+DG S SP++G F G + P + S S+ L ++F +D +++ GF +
Sbjct: 732 FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH 791
Query: 576 DECAKPD------RGG------------CEQRCLNTLGSYQCAC---EPGYELGPDRRSC 614
+EC P R G CE+ + T G+ C + C
Sbjct: 792 NECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 851
Query: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
A CGG + +G I +PGWP Y + NC W + A + I + FE F+ E N YD
Sbjct: 852 GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YD 907
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF------- 727
+E+ G + S L G + G +VP+ + S N + + F +DN+ S GFK H+
Sbjct: 908 VLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 967
Query: 728 FSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVL-HDNKHDCK------------EAEC 774
+S D +G + + C +G+ L H+ C+ +A C
Sbjct: 968 YSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALC 1027
Query: 775 EQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEV 834
+ PSG I SP +P+ YP+ CTW + T G ++ F F +E H +D+L +
Sbjct: 1028 GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLI 1083
Query: 835 FDGETEKSPILGRLCGNKIPDPLVA--TGN-KMFVRFVSDASVQRKGFQ----------- 880
+ + P L RL G+ +P + A GN + +RF+SD S+ +GF
Sbjct: 1084 TENGSFTQP-LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPC 1142
Query: 881 ---------------------ATHSTECGGRLKAESK---------------PRDLYSHA 904
T S G RL+ S+ PR +
Sbjct: 1143 EDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECG 1202
Query: 905 QFGDNN------------YPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELF 952
NN Y +C + + + G + +S +TF + + D ++++
Sbjct: 1203 ASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-----DVLKIY 1257
Query: 953 DGLDSTAVGLGRFCGSGPPE-EIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
DG D T LG F G+ + S + + + F++D +GF + Y S
Sbjct: 1258 DGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1308
Score = 206 bits (523), Expect = 1e-52
Identities = 177/662 (26%), Positives = 279/662 (42%), Gaps = 144/662 (21%)
Query: 460 AICGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
A CGG + ++ G+I SP YP Y C+W I V V L F +F+ E ++D
Sbjct: 1372 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1427
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKE-EDE 577
L V DG EN L+ G PE I ST N + ++F +D ++K+GFA F
Sbjct: 1428 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1487
Query: 578 CAKPD------RGGCEQRCLNTLGSYQCACEPGYELGPDRRS-----------------C 614
C P R G + +T+ C+PGYEL + R C
Sbjct: 1488 CRDPGVPMNGTRNGDGREPGDTV---VFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1544
Query: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
A CGG LT +G I +P +P YP +++C W + Y IS+ F F +E N YD
Sbjct: 1545 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YD 1600
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
++ I+ G S S L G F +++PE I S N M + F+SD +VS GF + + E
Sbjct: 1601 FLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRES 1660
Query: 735 SKDNG--------GCQHECVNTMGSYMCQCRNGFVLH-----------------DNKHDC 769
D G G ++ +T+ Y C G+VL +
Sbjct: 1661 CFDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1717
Query: 770 KEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAY 829
A C + G + SPN+P Y C + I A P + F +F Q +
Sbjct: 1718 CHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSI-AVPKEFV--VFGQFVF--FQTSLH 1772
Query: 830 DHLEVFDGETEKSPILGRLCGNKIPDPL-VATGNKMFVRFVSDASVQRKGFQ-------A 881
D +EV+DG T++S +L L G+ + L +++GN++ +RF S + KGF
Sbjct: 1773 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1832
Query: 882 THSTECG-------GR---------------------------LKAESKPRDLYSHAQFG 907
T ST+C GR ++ E+ P L AQ+
Sbjct: 1833 TSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL---AQWN 1889
Query: 908 DN--------------------------NYPGQVDCEWLLVSERGSRLELSFQTFEVEEE 941
D+ Y ++C W + G+ +++ +F E
Sbjct: 1890 DSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH- 1948
Query: 942 ADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
+D ++ +DG D+ A LG + G+ P + S +++ ++F +D +++ GFH+ Y
Sbjct: 1949 ---NWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYT 2005
Query: 1002 SI 1003
+I
Sbjct: 2006 AI 2007
Score = 197 bits (500), Expect = 5e-50
Identities = 154/510 (30%), Positives = 227/510 (44%), Gaps = 76/510 (14%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CGG + + G I SPN+P Y ++C W ITV+ Y + L F SF IE + YD+
Sbjct: 1546 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1601
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF-FKEEDEC 578
L + DG NSPLIG F PE I S+SNT+ + F SDG+V+ GF + K + C
Sbjct: 1602 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1661
Query: 579 AKP------DRGGCEQRCLNTLGSYQCACEPGYEL----------GPDRR--------SC 614
P R G + + +T+ Y C+ GY L G D R SC
Sbjct: 1662 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1718
Query: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
A CG T GT+ +P +PK Y NCV+ + P ++ + +F FF + +D
Sbjct: 1719 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFF-----QTSLHD 1773
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVI-TSQFNNMRIEFKSDNTVSKKGFKAHFF----- 728
VE++ G + +S L G+ E + S N + I F S ++ KGF HF
Sbjct: 1774 VVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HFVYQAVP 1831
Query: 729 -SDKDECS---KDNGGCQHECVNTMG-SYMCQCRNGFVLH------------------DN 765
+ +CS + G + +G S + C G++LH D+
Sbjct: 1832 RTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDS 1891
Query: 766 KHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQ 825
C C + G I SP +P+ Y + C W+I+ G I++ F E +
Sbjct: 1892 LPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN- 1949
Query: 826 ECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHST 885
+D L+ +DG +P LG G IP L +T N +++ F SD SV GF + T
Sbjct: 1950 ---WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY-T 2005
Query: 886 ECGGRLKAESKPRDLYSHAQFGDNNYPGQV 915
G L + +P+ S + GD G V
Sbjct: 2006 AIG--LDSCPEPQTPSSGIKIGDRYMVGDV 2033
Score = 183 bits (464), Expect = 8e-46
Identities = 141/501 (28%), Positives = 219/501 (43%), Gaps = 62/501 (12%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CG +EG + SPNYP +Y CV+ I V + + V F F+ HD
Sbjct: 1720 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1774
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIR-STSNTLWMKFVSDGTVNKAGFAANFFK----E 574
+EV DG ++ S L+ G E + S+ N + ++F S G + GF +
Sbjct: 1775 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1834
Query: 575 EDECAKPDRGGCEQRCLNTLG---SYQCACEPGYEL------------------GPDRRS 613
+C+ +R N S C PGY L +
Sbjct: 1835 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1894
Query: 614 CEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKY 673
C CGG+LTK GTI +PG+P+ Y N NCVW++ P I V+ F E N +
Sbjct: 1895 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1950
Query: 674 DYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS-DKD 732
D ++ + G + + G + G +P ++ S NN+ + F+SD +VS GF + + D
Sbjct: 1951 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2010
Query: 733 ECSK---DNGGCQHECVNTMGSYMC-QCRNGFVLHDNKH-DCKE--------------AE 773
C + + G + +G + QC G+ L + H C A+
Sbjct: 2011 SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQ 2070
Query: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
C + SG+I SP +P YPS +CTW I+ G + L F F E +D+LE
Sbjct: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFS----TETIHDYLE 2126
Query: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKA 893
V G +E S ++GRL G +IP L +T ++ + F SD S ++GF + +L++
Sbjct: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAY---QLQS 2183
Query: 894 ESKPRDLYSHAQFGDNNYPGQ 914
PR + G++ GQ
Sbjct: 2184 CPDPRPFRNGFVIGNDFTVGQ 2204
Score = 181 bits (458), Expect = 4e-45
Identities = 142/469 (30%), Positives = 217/469 (46%), Gaps = 64/469 (13%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CGG + G I SP +P +Y +C W I + + V L F +F E +DY
Sbjct: 2069 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2124
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECA 579
LEVR G+SE S +IGR G P + ST++ + F SD + NK GF + + +
Sbjct: 2125 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2184
Query: 580 ---KPDRGGCEQRCLNTLG-SYQCACEPGYEL----------GPDRR------SCEAACG 619
+P R G T+G + C PGY L G R CEA CG
Sbjct: 2185 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2244
Query: 620 GLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIW 679
G +T +NGTI +PG+P EYP ++C W V P I + F + E YD++ +W
Sbjct: 2245 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2300
Query: 680 SGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGF---------------- 723
G S G+F G E + S N + I+F SD T S GF
Sbjct: 2301 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFVLSYHAYQLRVCQPP 2358
Query: 724 ----KAHFFSDKDECSKDNGGCQHECV---NTMGSYMCQCRNGFVLH-DNKHDCKEAEC- 774
A ++ DE + +++C+ +G+ + CR G L D + C
Sbjct: 2359 PPVPNAEILTEDDE-FEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCP 2417
Query: 775 --EQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
E ++ S +G+I SP +PD YP+ + C W IS G+ I + F+ E+ +D L
Sbjct: 2418 ANELRLDS-TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVL 2472
Query: 833 EVFDGETEKSPILGRLCGN-KIPDPLVATGNKMFVRFVSDASVQRKGFQ 880
+V+DG +SP+L L G+ + + G+++F+++ +D +KGF+
Sbjct: 2473 QVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFR 2521
Score = 150 bits (379), Expect = 6e-36
Identities = 130/501 (25%), Positives = 207/501 (41%), Gaps = 63/501 (12%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
+A+CGG++R G I SP YP+ Y C W + V+ V F +F +E H +D
Sbjct: 1024 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1079
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRS---TSNTLWMKFVSDGTVNKAGFAANFFKEE 575
YL + + S PL R G D P I + + ++F+SD +++ GF F +
Sbjct: 1080 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1138
Query: 576 -DECAKPDRGGCEQRCLNTLG---SYQCACEPGYE---------LGPDRR-------SCE 615
+ C P R G + +C GY LG RR C
Sbjct: 1139 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1198
Query: 616 AACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDY 675
A CG T G + +P +P Y N C++ + I++ F L +V K
Sbjct: 1199 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1255
Query: 676 VEIWSGLSSESKLHGKFCGAEVPEV-ITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
I+ G + L G F GA + + ++S N + +EF SD + +GF+ + S +
Sbjct: 1256 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1313
Query: 735 SKDNGGCQHEC-VNTMGSY-----MCQCRNGFVLH---------------DNKHDCKEAE 773
+D G Q ++ G + + C G+ LH D AE
Sbjct: 1314 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE 1373
Query: 774 CEQKIH-SPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
C + SG I SP +P Y + C W I PG+ + L F F+ E ++D L
Sbjct: 1374 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFD----TEASHDIL 1429
Query: 833 EVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLK 892
V+DG E +L + G+ IP+ + +T N + ++F +D + + GF S+ +
Sbjct: 1430 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1489
Query: 893 AESKPRDLYSHAQFGDNNYPG 913
P + + GD PG
Sbjct: 1490 DPGVP---MNGTRNGDGREPG 1507
Score = 145 bits (367), Expect = 1e-34
Identities = 119/472 (25%), Positives = 201/472 (42%), Gaps = 102/472 (21%)
Query: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAP-TQYRISVKFEFFELEGNEVCKYDYV 676
CG L +GT T+P +P +Y N CVW + A T I + FE F+LE YD +
Sbjct: 508 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 563
Query: 677 EIWSG--LSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS-DKDE 733
I G + + G+ VP++I S + M + ++D +V GFK ++ +K+
Sbjct: 564 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 623
Query: 734 CSKDN----GGCQHECVNTMGSYMCQCRNGFVLHDNKHD-CKEAE------------CEQ 776
C G + + + +C+ GF L K C+E C
Sbjct: 624 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 683
Query: 777 KIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFD 836
+P G + SP++P+ Y + C W I + PG RI L+F++F++E +D L V D
Sbjct: 684 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKD 739
Query: 837 GETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQ--------------------- 875
G++ +SPILG G ++P L + + + + F +D S+
Sbjct: 740 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGI 799
Query: 876 ---------------------RKGFQATHSTE-----------------------CGGRL 891
+GF T TE CGG
Sbjct: 800 PINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHF 859
Query: 892 KAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVEL 951
A S + S G Y ++CEW++ +E G ++++F+ F+ E YD +E+
Sbjct: 860 SAPSGV--ILSPGWPG--YYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEV 911
Query: 952 FDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSI 1003
DG + + LG + G+ P+ ++S + + + F TD++ + GF I Y+S+
Sbjct: 912 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESV 963
Score = 135 bits (340), Expect = 2e-31
Identities = 90/304 (29%), Positives = 145/304 (47%), Gaps = 46/304 (15%)
Query: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677
CGG L LNGTI +PG+P YP NC W ++A + RI + F+ F LE +YDY+
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 80
Query: 678 IWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKD 737
++ G + + G +P +TS + + SD VS GFK ++ + S
Sbjct: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 139
Query: 738 NGGCQHECV------NTMGSYMCQCRNGFVLHDNKH------------------DCK-EA 772
N G + V + C G++L + C+ E
Sbjct: 140 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 199
Query: 773 ECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
C + SG+I+SP++P++Y + +CTW I A PG I L F++F++E+ YD+L
Sbjct: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 255
Query: 833 EVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQA--------THS 884
E+ E + P + L G IP P+++ N + + FV+D++ + +GF A TH+
Sbjct: 256 EI---EGSEPPTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 311
Query: 885 TECG 888
T G
Sbjct: 312 TSTG 315
Score = 115 bits (287), Expect = 3e-25
Identities = 87/302 (28%), Positives = 137/302 (45%), Gaps = 46/302 (15%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
EA+CGG I G I SP YPD+Y ++C W + V + + F + E YD
Sbjct: 2240 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2295
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGF----------- 567
++ V DG +NSP IG+F G E + STSN + +KF SD T +GF
Sbjct: 2296 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTT--SGFFVLSYHAYQLR 2353
Query: 568 ---------AANFFKEEDECAKPDRGGCEQRCL---NTLGSYQCACEPGYELGPDRRS-- 613
A E+DE D +CL +G+ C G L D
Sbjct: 2354 VCQPPPPVPNAEILTEDDEFEIGDI--IRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV 2411
Query: 614 CEAACGGLLTKLN--GTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVC 671
C+ C +L+ G I +PG+P YP + C W + Y I++ EFF+ E
Sbjct: 2412 CQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK---- 2467
Query: 672 KYDYVEIWSGLSSES----KLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF 727
++D ++++ G + +S L G + A ITS + + +++ +D+ +KKGF+ +
Sbjct: 2468 EFDVLQVYDGPNIQSPVLISLSGDYSSA---FNITSNGHEVFLQWSADHGNNKKGFRIRY 2524
Query: 728 FS 729
+
Sbjct: 2525 IA 2526
Score = 112 bits (281), Expect = 1e-24
Identities = 82/290 (28%), Positives = 124/290 (42%), Gaps = 36/290 (12%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
CGG ++ G I+SP +P Y C W I E + + FQSF +E YDYL
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK-EEDECAK 580
+ DG + R G+ P + ST + ++ SD V+ GF + + + C
Sbjct: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140
Query: 581 PD---RGGCEQRCLNTLGSYQCACEPGYEL-GPDRRSC-------------------EAA 617
P +G + + +C GY L G + +C E A
Sbjct: 141 PGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA 200
Query: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677
CGG + +G I++P +P EY N +C W +VA IS+ F F++E KYDY+E
Sbjct: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYLE 256
Query: 678 IWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF 727
I L G +P I S N +R+ F +D+ +GF A +
Sbjct: 257 IEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302
Score = 100 bits (250), Expect = 5e-21
Identities = 78/299 (26%), Positives = 132/299 (44%), Gaps = 68/299 (22%)
Query: 764 DNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHR-IKLAFSEFEIE 822
D++ CK C + PSG TSPN+P +Y S +C W I+A ++ I++ F EF++
Sbjct: 498 DHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDL- 556
Query: 823 QHQECAYDHLEVFDGETEKSP--ILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQ 880
E YD L + DG P +L L G+ +PD +V+ ++M++ +D SV GF+
Sbjct: 557 ---EIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFK 613
Query: 881 ATH----STECG--GRLKAESKPRDLYSH-------AQFG------------DNN----- 910
+ CG G + D +S+ QFG +NN
Sbjct: 614 VNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 673
Query: 911 ---------------------------YPGQVDCEWLLVSERGSRLELSFQTFEVEEEAD 943
Y ++C W ++S+ GSR+ LSF F++E +
Sbjct: 674 IPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ-- 731
Query: 944 CGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
+D++ + DG + LG F G+ P + S + + F D +++ +GF+I Y +
Sbjct: 732 --FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT 788
Score = 77.0 bits (188), Expect = 8e-14
Identities = 41/104 (39%), Positives = 59/104 (56%), Gaps = 5/104 (4%)
Query: 343 LYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSL 401
L RC A CG + NG + SPG+P+ YP++ C W V V PG I +NFT +
Sbjct: 2236 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2293
Query: 402 CWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRS 445
YD+I V DG + SP +G+F G+ E + ST +++ I+F S
Sbjct: 2294 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHS 2335
Score = 70.1 bits (170), Expect = 1e-11
Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 4/112 (3%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG + + +G + SPGFP YPS C W +++ G + L F S+ +DY+E
Sbjct: 2071 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2126
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
VR G S ++GR G ++P L ST + F S + +GF VY+A
Sbjct: 2127 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178
Score = 68.6 bits (166), Expect = 3e-11
Identities = 39/112 (34%), Positives = 57/112 (50%), Gaps = 4/112 (3%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L S+G + SP FP+ YP C W ++V I L F + + + YD++
Sbjct: 1548 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1603
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
+ DG SPL+G F KLPE + S+ + M + FRS + GF Y+A
Sbjct: 1604 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1655
Score = 67.4 bits (163), Expect = 6e-11
Identities = 77/318 (24%), Positives = 109/318 (34%), Gaps = 71/318 (22%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG TL+ NG + SPGFP GYP+ +C W + +I + F + L + YDY+
Sbjct: 25 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 80
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI----CGG 464
+ DG+ + R G LP +TST S + S GF YE + CG
Sbjct: 81 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 140
Query: 465 EIRKNEGQIQS--------------PNYPDDYRPMKECV--------WKITV----SESY 498
+G + Y D P C+ W V +E
Sbjct: 141 PGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA 200
Query: 499 HVG--------LTFQSFEIERHDNC-------------------------AYDYLEVRDG 525
G ++ SF E H+N YDYLE+
Sbjct: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEG- 259
Query: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGG 585
+ P G + P I S N L + FV+D GF+A + G
Sbjct: 260 ---SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGE 316
Query: 586 CEQRCLNTLGSYQCACEP 603
E+ T G+ A P
Sbjct: 317 LEEHNRTTTGAIAVASTP 334
Score = 65.5 bits (158), Expect = 2e-10
Identities = 39/131 (29%), Positives = 68/131 (51%), Gaps = 5/131 (3%)
Query: 332 LSKGDIAQARKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLN 390
L G + + + +C A CG +G + SPG+P Y +C W + PG I +
Sbjct: 837 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 896
Query: 391 FTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWV 450
F + +++ L YD +EV DG SPLLG + G ++P+ L S+ + +++ F + ++
Sbjct: 897 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 952
Query: 451 GKGFAAVYEAI 461
GF YE++
Sbjct: 953 NNGFKIHYESV 963
Score = 64.7 bits (156), Expect = 4e-10
Identities = 35/116 (30%), Positives = 59/116 (50%), Gaps = 10/116 (8%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKI---VLNFTTMDLYKSSLCWYD 405
CG L + G + SPG+P Y + +C+W+++V G I V++F T +D
Sbjct: 1899 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN-------WD 1951
Query: 406 YIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI 461
++ DG +P LG + G +P +L ST + +++ F+S + GF Y AI
Sbjct: 1952 SLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2007
Score = 63.5 bits (153), Expect = 9e-10
Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
ACG T++ S+G +SSP FPN Y + C W + PG+ I L FT + + YDY+
Sbjct: 200 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 255
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIR 467
E+ P G +P + S + + + F + SN +GF+A Y+
Sbjct: 256 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 311
Query: 468 KNEGQIQSPN 477
+ G+++ N
Sbjct: 312 TSTGELEEHN 321
Score = 62.8 bits (151), Expect = 2e-09
Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 4/93 (4%)
Query: 910 NYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSG 969
NYP +DC W + G + L F F E +DY+E+ G T+ +GR G
Sbjct: 2090 NYPSSLDCTWTINLPIGFGVHLQFVNFSTETI----HDYLEVRSGSSETSTVIGRLSGPQ 2145
Query: 970 PPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
P ++S ++FH+D + NK+GFHI Y++
Sbjct: 2146 IPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2178
Score = 57.0 bits (136), Expect = 9e-08
Identities = 37/122 (30%), Positives = 55/122 (45%), Gaps = 9/122 (7%)
Query: 344 YRCPAC-----GETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYK 398
Y P+C G ES+G + SPG+P Y + C+W + V PG + L F D
Sbjct: 1365 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1424
Query: 399 SSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
S +D + V DG LL G +PE + ST + + I+F + GFA +
Sbjct: 1425 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1480
Query: 459 EA 460
+
Sbjct: 1481 SS 1482
Score = 57.0 bits (136), Expect = 9e-08
Identities = 34/112 (30%), Positives = 58/112 (51%), Gaps = 10/112 (8%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG + A + +YS + YP DC WL+ G+ + ++F + E Y
Sbjct: 2243 CGGNITAMNGT--IYSPGY--PDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----Y 2294
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHI 998
D++ ++DG D + +G+F G+ E +YS + +LI FH+D T + GF +
Sbjct: 2295 DFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFV 2344
Score = 53.9 bits (128), Expect = 7e-07
Identities = 26/94 (27%), Positives = 48/94 (51%), Gaps = 4/94 (4%)
Query: 911 YPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGP 970
YP +C W++++E +R+++ FQ+F +EEE YDY+ L+DG R G
Sbjct: 45 YPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLSLYDGHPHPTNFRTRLTGFHL 100
Query: 971 PEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIR 1004
P + S + +D ++ GF + Y+ ++
Sbjct: 101 PPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQ 134
Score = 53.9 bits (128), Expect = 7e-07
Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 12/115 (10%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG ++ S + S F N Y DC W +V+E G + L F F++EE+ Y
Sbjct: 201 CGGTMRGSS---GIISSPSF-PNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----Y 252
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
DY+E+ +G + + L G P I S + + +HF TD +GF Y+
Sbjct: 253 DYLEI-EGSEPPTIWLS---GMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303
Score = 53.1 bits (126), Expect = 1e-06
Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%)
Query: 341 RKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKS 399
R L C A CG S G + SP +P Y +C++ ++V P E +V F +++
Sbjct: 1713 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1769
Query: 400 SLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVL-TSTDSRMWIEFRSSSNWVGKGFAAVY 458
SL +D +EV DG ++S LL G E L S+ +++ I F S KGF VY
Sbjct: 1770 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1827
Query: 459 EAI 461
+A+
Sbjct: 1828 QAV 1830
Score = 50.4 bits (119), Expect = 8e-06
Identities = 35/116 (30%), Positives = 54/116 (46%), Gaps = 6/116 (5%)
Query: 346 CPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405
CPA E +S G + SPG+P+ YP+ C W +SV G I + K +D
Sbjct: 2416 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2470
Query: 406 YIEVRDGYWRKSPLLGRFCGDKLPEV-LTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
++V DG +SP+L GD +TS +++++ + KGF Y A
Sbjct: 2471 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2526
Score = 43.9 bits (102), Expect = 8e-04
Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 5/93 (5%)
Query: 909 NNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGS 968
++YP C W + E+G + + + F+ E+E +D ++++DG + + L G
Sbjct: 2436 DSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQSPVLISLSGD 2491
Query: 969 -GPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
I S G V + + D NKKGF IRY
Sbjct: 2492 YSSAFNITSNGHEVFLQWSADHGNNKKGFRIRY 2524
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 218 bits (555), Expect = 2e-56
Identities = 201/831 (24%), Positives = 329/831 (39%), Gaps = 191/831 (22%)
Query: 341 RKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIV-LNFTTMDLYKS 399
R + + CG LQ +G +SP FP Y S C+W ++ K++ +NF DL
Sbjct: 436 RPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE-- 493
Query: 400 SLCWYDYIEVRDGYWRKSP--LLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAV 457
YD + + DG P +L G +P+++ S S+MW+ ++ + GF
Sbjct: 494 --IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVN 551
Query: 458 YEAI----CGGE------IRKNEG------------------------------------ 471
Y+ I CG IR+ +G
Sbjct: 552 YKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIP 611
Query: 472 ---------------QIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCA 516
+ SP+YP+ Y C+W I + L+F F++E
Sbjct: 612 ICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ---- 667
Query: 517 YDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK-EE 575
+D+L V+DG S SP++G F G + P + S S+ L ++F +D +++ GF +
Sbjct: 668 FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH 727
Query: 576 DECAKPD------RGG------------CEQRCLNTLGSYQCAC---EPGYELGPDRRSC 614
+EC P R G CE+ + T G+ C + C
Sbjct: 728 NECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 787
Query: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
A CGG + +G I +PGWP Y + NC W + A + I + FE F+ E N YD
Sbjct: 788 GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YD 843
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF------- 727
+E+ G + S L G + G +VP+ + S N + + F +DN+ S GFK H+
Sbjct: 844 VLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 903
Query: 728 FSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVL-HDNKHDCK------------EAEC 774
+S D +G + + C +G+ L H+ C+ +A C
Sbjct: 904 YSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALC 963
Query: 775 EQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEV 834
+ PSG I SP +P+ YP+ CTW + T G ++ F F +E H +D+L +
Sbjct: 964 GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLI 1019
Query: 835 FDGETEKSPILGRLCGNKIPDPLVA--TGN-KMFVRFVSDASVQRKGFQ----------- 880
+ + P L RL G+ +P + A GN + +RF+SD S+ +GF
Sbjct: 1020 TENGSFTQP-LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPC 1078
Query: 881 ---------------------ATHSTECGGRLKAESK---------------PRDLYSHA 904
T S G RL+ S+ PR +
Sbjct: 1079 EDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECG 1138
Query: 905 QFGDNN------------YPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELF 952
NN Y +C + + + G + +S +TF + + D ++++
Sbjct: 1139 ASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-----DVLKIY 1193
Query: 953 DGLDSTAVGLGRFCGSGPPE-EIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
DG D T LG F G+ + S + + + F++D +GF + Y S
Sbjct: 1194 DGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1244
Score = 206 bits (523), Expect = 1e-52
Identities = 177/662 (26%), Positives = 279/662 (42%), Gaps = 144/662 (21%)
Query: 460 AICGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
A CGG + ++ G+I SP YP Y C+W I V V L F +F+ E ++D
Sbjct: 1308 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1363
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKE-EDE 577
L V DG EN L+ G PE I ST N + ++F +D ++K+GFA F
Sbjct: 1364 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1423
Query: 578 CAKPD------RGGCEQRCLNTLGSYQCACEPGYELGPDRRS-----------------C 614
C P R G + +T+ C+PGYEL + R C
Sbjct: 1424 CRDPGVPMNGTRNGDGREPGDTV---VFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1480
Query: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
A CGG LT +G I +P +P YP +++C W + Y IS+ F F +E N YD
Sbjct: 1481 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YD 1536
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
++ I+ G S S L G F +++PE I S N M + F+SD +VS GF + + E
Sbjct: 1537 FLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRES 1596
Query: 735 SKDNG--------GCQHECVNTMGSYMCQCRNGFVLH-----------------DNKHDC 769
D G G ++ +T+ Y C G+VL +
Sbjct: 1597 CFDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1653
Query: 770 KEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAY 829
A C + G + SPN+P Y C + I A P + F +F Q +
Sbjct: 1654 CHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSI-AVPKEFV--VFGQFVF--FQTSLH 1708
Query: 830 DHLEVFDGETEKSPILGRLCGNKIPDPL-VATGNKMFVRFVSDASVQRKGFQ-------A 881
D +EV+DG T++S +L L G+ + L +++GN++ +RF S + KGF
Sbjct: 1709 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1768
Query: 882 THSTECG-------GR---------------------------LKAESKPRDLYSHAQFG 907
T ST+C GR ++ E+ P L AQ+
Sbjct: 1769 TSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL---AQWN 1825
Query: 908 DN--------------------------NYPGQVDCEWLLVSERGSRLELSFQTFEVEEE 941
D+ Y ++C W + G+ +++ +F E
Sbjct: 1826 DSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH- 1884
Query: 942 ADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
+D ++ +DG D+ A LG + G+ P + S +++ ++F +D +++ GFH+ Y
Sbjct: 1885 ---NWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYT 1941
Query: 1002 SI 1003
+I
Sbjct: 1942 AI 1943
Score = 197 bits (500), Expect = 5e-50
Identities = 154/510 (30%), Positives = 227/510 (44%), Gaps = 76/510 (14%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CGG + + G I SPN+P Y ++C W ITV+ Y + L F SF IE + YD+
Sbjct: 1482 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1537
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF-FKEEDEC 578
L + DG NSPLIG F PE I S+SNT+ + F SDG+V+ GF + K + C
Sbjct: 1538 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1597
Query: 579 AKP------DRGGCEQRCLNTLGSYQCACEPGYEL----------GPDRR--------SC 614
P R G + + +T+ Y C+ GY L G D R SC
Sbjct: 1598 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1654
Query: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
A CG T GT+ +P +PK Y NCV+ + P ++ + +F FF + +D
Sbjct: 1655 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFF-----QTSLHD 1709
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVI-TSQFNNMRIEFKSDNTVSKKGFKAHFF----- 728
VE++ G + +S L G+ E + S N + I F S ++ KGF HF
Sbjct: 1710 VVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HFVYQAVP 1767
Query: 729 -SDKDECS---KDNGGCQHECVNTMG-SYMCQCRNGFVLH------------------DN 765
+ +CS + G + +G S + C G++LH D+
Sbjct: 1768 RTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDS 1827
Query: 766 KHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQ 825
C C + G I SP +P+ Y + C W+I+ G I++ F E +
Sbjct: 1828 LPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN- 1885
Query: 826 ECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHST 885
+D L+ +DG +P LG G IP L +T N +++ F SD SV GF + T
Sbjct: 1886 ---WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY-T 1941
Query: 886 ECGGRLKAESKPRDLYSHAQFGDNNYPGQV 915
G L + +P+ S + GD G V
Sbjct: 1942 AIG--LDSCPEPQTPSSGIKIGDRYMVGDV 1969
Score = 187 bits (476), Expect = 3e-47
Identities = 172/680 (25%), Positives = 273/680 (40%), Gaps = 159/680 (23%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
CGG ++ G I+SP +P Y C W I E + + FQSF +E YDYL
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK-EEDECAK 580
+ DG + R G+ P + ST + ++ SD V+ GF + + + C
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 180
Query: 581 PD---RGGCEQRCLNTLGSYQCACEPGYEL-GPDRRSC-------------------EAA 617
P +G + + +C GY L G + +C E A
Sbjct: 181 PGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA 240
Query: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677
CGG + +G I++P +P EY N +C W +VA IS+ F F++E KYDY+E
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYLE 296
Query: 678 IWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF---------- 727
I L G +P I S N +R+ F +D+ +GF A +
Sbjct: 297 IEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKS 352
Query: 728 -----FSDKDECSK----DNGGC-----------QHECVNTMGS-------YMCQCRNGF 760
F KD +K + GG + E +GS C +
Sbjct: 353 RGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDY 412
Query: 761 VLH------------------DNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTW 802
VL D++ CK C + PSG TSPN+P +Y S +C W
Sbjct: 413 VLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVW 472
Query: 803 EISATPGHR-IKLAFSEFEIEQHQECAYDHLEVFDGETEKSP--ILGRLCGNKIPDPLVA 859
I+A ++ I++ F EF++ E YD L + DG P +L L G+ +PD +V+
Sbjct: 473 VITAVNTNKVIQINFEEFDL----EIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVS 528
Query: 860 TGNKMFVRFVSDASVQRKGFQATH----STECG--GRLKAESKPRDLYSH-------AQF 906
++M++ +D SV GF+ + CG G + D +S+ QF
Sbjct: 529 MSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQF 588
Query: 907 G------------DNN--------------------------------YPGQVDCEWLLV 922
G +NN Y ++C W ++
Sbjct: 589 GFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTII 648
Query: 923 SERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVL 982
S+ GSR+ LSF F++E + +D++ + DG + LG F G+ P + S +
Sbjct: 649 SDPGSRIHLSFNDFDLESQ----FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILR 704
Query: 983 IHFHTDDTINKKGFHIRYKS 1002
+ F D +++ +GF+I Y +
Sbjct: 705 LEFQADHSMSGRGFNITYNT 724
Score = 183 bits (464), Expect = 8e-46
Identities = 141/501 (28%), Positives = 219/501 (43%), Gaps = 62/501 (12%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CG +EG + SPNYP +Y CV+ I V + + V F F+ HD
Sbjct: 1656 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1710
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIR-STSNTLWMKFVSDGTVNKAGFAANFFK----E 574
+EV DG ++ S L+ G E + S+ N + ++F S G + GF +
Sbjct: 1711 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1770
Query: 575 EDECAKPDRGGCEQRCLNTLG---SYQCACEPGYEL------------------GPDRRS 613
+C+ +R N S C PGY L +
Sbjct: 1771 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1830
Query: 614 CEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKY 673
C CGG+LTK GTI +PG+P+ Y N NCVW++ P I V+ F E N +
Sbjct: 1831 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1886
Query: 674 DYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS-DKD 732
D ++ + G + + G + G +P ++ S NN+ + F+SD +VS GF + + D
Sbjct: 1887 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 1946
Query: 733 ECSK---DNGGCQHECVNTMGSYMC-QCRNGFVLHDNKH-DCKE--------------AE 773
C + + G + +G + QC G+ L + H C A+
Sbjct: 1947 SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQ 2006
Query: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
C + SG+I SP +P YPS +CTW I+ G + L F F E +D+LE
Sbjct: 2007 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFS----TETIHDYLE 2062
Query: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKA 893
V G +E S ++GRL G +IP L +T ++ + F SD S ++GF + +L++
Sbjct: 2063 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAY---QLQS 2119
Query: 894 ESKPRDLYSHAQFGDNNYPGQ 914
PR + G++ GQ
Sbjct: 2120 CPDPRPFRNGFVIGNDFTVGQ 2140
Score = 182 bits (462), Expect = 1e-45
Identities = 172/686 (25%), Positives = 279/686 (40%), Gaps = 165/686 (24%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
E CGG +R + G I SP++P++Y +C W I + L F F++E YD
Sbjct: 238 EDACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YD 293
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF------- 571
YLE+ + P G + P I S N L + FV+D GF+A +
Sbjct: 294 YLEIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAID 349
Query: 572 --------FKEEDECAK----------------PDRGGCE--QRCLN--TLGS-YQCACE 602
F +D K PD G E +R + +LGS Q +C+
Sbjct: 350 FKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCD 409
Query: 603 PGYEL-GPDRRSCEA------------------ACGGLLTKLNGTITTPGWPKEYPPNKN 643
Y L G +C+ CG L +GT T+P +P +Y N
Sbjct: 410 EDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQ 469
Query: 644 CVWQVVAP-TQYRISVKFEFFELEGNEVCKYDYVEIWSG--LSSESKLHGKFCGAEVPEV 700
CVW + A T I + FE F+LE YD + I G + + G+ VP++
Sbjct: 470 CVWVITAVNTNKVIQINFEEFDLE----IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDL 525
Query: 701 ITSQFNNMRIEFKSDNTVSKKGFKAHFFS-DKDECSKDN----GGCQHECVNTMGSYMCQ 755
I S + M + ++D +V GFK ++ +K+ C G + + + +
Sbjct: 526 IVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFE 585
Query: 756 CRNGFVLHDNKHD-CKEAE------------CEQKIHSPSGLITSPNWPDKYPSRKECTW 802
C+ GF L K C+E C +P G + SP++P+ Y + C W
Sbjct: 586 CQFGFELIGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIW 645
Query: 803 EISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGN 862
I + PG RI L+F++F++E +D L V DG++ +SPILG G ++P L + +
Sbjct: 646 TIISDPGSRIHLSFNDFDLESQ----FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSH 701
Query: 863 KMFVRFVSDASVQ------------------------------------------RKGFQ 880
+ + F +D S+ +GF
Sbjct: 702 ILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINARRFGDNFQLGSSISVICEEGFI 761
Query: 881 ATHSTE-----------------------CGGRLKAESKPRDLYSHAQFGDNNYPGQVDC 917
T TE CGG A S + S G Y ++C
Sbjct: 762 KTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSGV--ILSPGWPG--YYKDSLNC 817
Query: 918 EWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSI 977
EW++ +E G ++++F+ F+ E YD +E+ DG + + LG + G+ P+ ++S
Sbjct: 818 EWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSS 873
Query: 978 GDSVLIHFHTDDTINKKGFHIRYKSI 1003
+ + + F TD++ + GF I Y+S+
Sbjct: 874 SNFIYLLFTTDNSRSNNGFKIHYESV 899
Score = 181 bits (458), Expect = 4e-45
Identities = 142/469 (30%), Positives = 217/469 (46%), Gaps = 64/469 (13%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CGG + G I SP +P +Y +C W I + + V L F +F E +DY
Sbjct: 2005 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2060
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECA 579
LEVR G+SE S +IGR G P + ST++ + F SD + NK GF + + +
Sbjct: 2061 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2120
Query: 580 ---KPDRGGCEQRCLNTLG-SYQCACEPGYEL----------GPDRR------SCEAACG 619
+P R G T+G + C PGY L G R CEA CG
Sbjct: 2121 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2180
Query: 620 GLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIW 679
G +T +NGTI +PG+P EYP ++C W V P I + F + E YD++ +W
Sbjct: 2181 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2236
Query: 680 SGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGF---------------- 723
G S G+F G E + S N + I+F SD T S GF
Sbjct: 2237 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFVLSYHAYQLRVCQPP 2294
Query: 724 ----KAHFFSDKDECSKDNGGCQHECV---NTMGSYMCQCRNGFVLH-DNKHDCKEAEC- 774
A ++ DE + +++C+ +G+ + CR G L D + C
Sbjct: 2295 PPVPNAEILTEDDE-FEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCP 2353
Query: 775 --EQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
E ++ S +G+I SP +PD YP+ + C W IS G+ I + F+ E+ +D L
Sbjct: 2354 ANELRLDS-TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVL 2408
Query: 833 EVFDGETEKSPILGRLCGN-KIPDPLVATGNKMFVRFVSDASVQRKGFQ 880
+V+DG +SP+L L G+ + + G+++F+++ +D +KGF+
Sbjct: 2409 QVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFR 2457
Score = 166 bits (419), Expect = 1e-40
Identities = 184/725 (25%), Positives = 282/725 (38%), Gaps = 169/725 (23%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG TL+ NG + SPGFP GYP+ +C W + +I + F + L + YDY+
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI----CGG 464
+ DG+ + R G LP +TST S + S GF YE + CG
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 180
Query: 465 EIRKNEGQIQS--------------PNYPDDYRPMKECV--------WKITV----SESY 498
+G + Y D P C+ W V +E
Sbjct: 181 PGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA 240
Query: 499 HVG--------LTFQSFEIERHDNC-------------------------AYDYLEVRDG 525
G ++ SF E H+N YDYLE+
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEG- 299
Query: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF-------------- 571
+ P G + P I S N L + FV+D GF+A +
Sbjct: 300 ---SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAIDFKSRGFK 356
Query: 572 -FKEEDECAK----------------PDRGGCE--QRCLN--TLGS-YQCACEPGYEL-G 608
F +D K PD G E +R + +LGS Q +C+ Y L G
Sbjct: 357 LFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTVQFSCDEDYVLQG 416
Query: 609 PDRRSCE------------------AACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVA 650
+C+ CG L +GT T+P +P +Y N CVW + A
Sbjct: 417 AKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITA 476
Query: 651 -PTQYRISVKFEFFELEGNEVCKYDYVEIWSG--LSSESKLHGKFCGAEVPEVITSQFNN 707
T I + FE F+LE YD + I G + + G+ VP++I S +
Sbjct: 477 VNTNKVIQINFEEFDLE----IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQ 532
Query: 708 MRIEFKSDNTVSKKGFKAHFFS-DKDECSKDN----GGCQHECVNTMGSYMCQCRNGFVL 762
M + ++D +V GFK ++ +K+ C G + + + +C+ GF L
Sbjct: 533 MWLHLQTDESVGSVGFKVNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFEL 592
Query: 763 HDNKH-DCKEAE------------CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPG 809
K C+E C +P G + SP++P+ Y + C W I + PG
Sbjct: 593 IGEKSIVCQENNQWSANIPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPG 652
Query: 810 HRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFV 869
RI L+F++F++E +D L V DG++ +SPILG G ++P L + + + + F
Sbjct: 653 SRIHLSFNDFDLESQ----FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQ 708
Query: 870 SDASVQRKGFQATHST----ECGGRLKAESKPRDLYSHAQFGDNNYPG---QVDCEWLLV 922
+D S+ +GF T++T EC P + +FGDN G V CE +
Sbjct: 709 ADHSMSGRGFNITYNTFGHNEC-------PDPGIPINARRFGDNFQLGSSISVICEEGFI 761
Query: 923 SERGS 927
+G+
Sbjct: 762 KTQGT 766
Score = 150 bits (379), Expect = 6e-36
Identities = 130/501 (25%), Positives = 207/501 (41%), Gaps = 63/501 (12%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
+A+CGG++R G I SP YP+ Y C W + V+ V F +F +E H +D
Sbjct: 960 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1015
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRS---TSNTLWMKFVSDGTVNKAGFAANFFKEE 575
YL + + S PL R G D P I + + ++F+SD +++ GF F +
Sbjct: 1016 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1074
Query: 576 -DECAKPDRGGCEQRCLNTLG---SYQCACEPGYE---------LGPDRR-------SCE 615
+ C P R G + +C GY LG RR C
Sbjct: 1075 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1134
Query: 616 AACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDY 675
A CG T G + +P +P Y N C++ + I++ F L +V K
Sbjct: 1135 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1191
Query: 676 VEIWSGLSSESKLHGKFCGAEVPEV-ITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
I+ G + L G F GA + + ++S N + +EF SD + +GF+ + S +
Sbjct: 1192 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1249
Query: 735 SKDNGGCQHEC-VNTMGSY-----MCQCRNGFVLH---------------DNKHDCKEAE 773
+D G Q ++ G + + C G+ LH D AE
Sbjct: 1250 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE 1309
Query: 774 CEQKIH-SPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
C + SG I SP +P Y + C W I PG+ + L F F+ E ++D L
Sbjct: 1310 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFD----TEASHDIL 1365
Query: 833 EVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLK 892
V+DG E +L + G+ IP+ + +T N + ++F +D + + GF S+ +
Sbjct: 1366 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1425
Query: 893 AESKPRDLYSHAQFGDNNYPG 913
P + + GD PG
Sbjct: 1426 DPGVP---MNGTRNGDGREPG 1443
Score = 115 bits (287), Expect = 3e-25
Identities = 87/302 (28%), Positives = 137/302 (45%), Gaps = 46/302 (15%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
EA+CGG I G I SP YPD+Y ++C W + V + + F + E YD
Sbjct: 2176 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2231
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGF----------- 567
++ V DG +NSP IG+F G E + STSN + +KF SD T +GF
Sbjct: 2232 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTT--SGFFVLSYHAYQLR 2289
Query: 568 ---------AANFFKEEDECAKPDRGGCEQRCL---NTLGSYQCACEPGYELGPDRRS-- 613
A E+DE D +CL +G+ C G L D
Sbjct: 2290 VCQPPPPVPNAEILTEDDEFEIGDI--IRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV 2347
Query: 614 CEAACGGLLTKLN--GTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVC 671
C+ C +L+ G I +PG+P YP + C W + Y I++ EFF+ E
Sbjct: 2348 CQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK---- 2403
Query: 672 KYDYVEIWSGLSSES----KLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF 727
++D ++++ G + +S L G + A ITS + + +++ +D+ +KKGF+ +
Sbjct: 2404 EFDVLQVYDGPNIQSPVLISLSGDYSSA---FNITSNGHEVFLQWSADHGNNKKGFRIRY 2460
Query: 728 FS 729
+
Sbjct: 2461 IA 2462
Score = 77.0 bits (188), Expect = 8e-14
Identities = 41/104 (39%), Positives = 59/104 (56%), Gaps = 5/104 (4%)
Query: 343 LYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSL 401
L RC A CG + NG + SPG+P+ YP++ C W V V PG I +NFT +
Sbjct: 2172 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2229
Query: 402 CWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRS 445
YD+I V DG + SP +G+F G+ E + ST +++ I+F S
Sbjct: 2230 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHS 2271
Score = 70.1 bits (170), Expect = 1e-11
Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 4/112 (3%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG + + +G + SPGFP YPS C W +++ G + L F S+ +DY+E
Sbjct: 2007 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2062
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
VR G S ++GR G ++P L ST + F S + +GF VY+A
Sbjct: 2063 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2114
Score = 68.6 bits (166), Expect = 3e-11
Identities = 39/112 (34%), Positives = 57/112 (50%), Gaps = 4/112 (3%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L S+G + SP FP+ YP C W ++V I L F + + + YD++
Sbjct: 1484 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1539
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
+ DG SPL+G F KLPE + S+ + M + FRS + GF Y+A
Sbjct: 1540 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1591
Score = 65.5 bits (158), Expect = 2e-10
Identities = 39/131 (29%), Positives = 68/131 (51%), Gaps = 5/131 (3%)
Query: 332 LSKGDIAQARKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLN 390
L G + + + +C A CG +G + SPG+P Y +C W + PG I +
Sbjct: 773 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 832
Query: 391 FTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWV 450
F + +++ L YD +EV DG SPLLG + G ++P+ L S+ + +++ F + ++
Sbjct: 833 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 888
Query: 451 GKGFAAVYEAI 461
GF YE++
Sbjct: 889 NNGFKIHYESV 899
Score = 64.7 bits (156), Expect = 4e-10
Identities = 35/116 (30%), Positives = 59/116 (50%), Gaps = 10/116 (8%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKI---VLNFTTMDLYKSSLCWYD 405
CG L + G + SPG+P Y + +C+W+++V G I V++F T +D
Sbjct: 1835 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN-------WD 1887
Query: 406 YIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI 461
++ DG +P LG + G +P +L ST + +++ F+S + GF Y AI
Sbjct: 1888 SLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 1943
Score = 63.2 bits (152), Expect = 1e-09
Identities = 36/112 (32%), Positives = 56/112 (50%), Gaps = 8/112 (7%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
ACG T++ S+G +SSP FPN Y + C W + PG+ I L FT + + YDY+
Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 295
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYE 459
E+ P G +P + S + + + F + SN +GF+A Y+
Sbjct: 296 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Score = 62.8 bits (151), Expect = 2e-09
Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 4/93 (4%)
Query: 910 NYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSG 969
NYP +DC W + G + L F F E +DY+E+ G T+ +GR G
Sbjct: 2026 NYPSSLDCTWTINLPIGFGVHLQFVNFSTETI----HDYLEVRSGSSETSTVIGRLSGPQ 2081
Query: 970 PPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
P ++S ++FH+D + NK+GFHI Y++
Sbjct: 2082 IPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2114
Score = 57.0 bits (136), Expect = 9e-08
Identities = 37/122 (30%), Positives = 55/122 (45%), Gaps = 9/122 (7%)
Query: 344 YRCPAC-----GETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYK 398
Y P+C G ES+G + SPG+P Y + C+W + V PG + L F D
Sbjct: 1301 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1360
Query: 399 SSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
S +D + V DG LL G +PE + ST + + I+F + GFA +
Sbjct: 1361 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1416
Query: 459 EA 460
+
Sbjct: 1417 SS 1418
Score = 57.0 bits (136), Expect = 9e-08
Identities = 34/112 (30%), Positives = 58/112 (51%), Gaps = 10/112 (8%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG + A + +YS + YP DC WL+ G+ + ++F + E Y
Sbjct: 2179 CGGNITAMNGT--IYSPGY--PDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----Y 2230
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHI 998
D++ ++DG D + +G+F G+ E +YS + +LI FH+D T + GF +
Sbjct: 2231 DFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFV 2280
Score = 54.7 bits (130), Expect = 4e-07
Identities = 35/128 (27%), Positives = 59/128 (46%), Gaps = 12/128 (9%)
Query: 877 KGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTF 936
KGF T CGG LK + + YP +C W++++E +R+++ FQ+F
Sbjct: 59 KGFIYT----CGGTLKGLNGTIESPGFPY----GYPNGANCTWVIIAEERNRIQIVFQSF 110
Query: 937 EVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGF 996
+EEE YDY+ L+DG R G P + S + +D ++ GF
Sbjct: 111 ALEEE----YDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGF 166
Query: 997 HIRYKSIR 1004
+ Y+ ++
Sbjct: 167 KVYYEELQ 174
Score = 53.1 bits (126), Expect = 1e-06
Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%)
Query: 341 RKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKS 399
R L C A CG S G + SP +P Y +C++ ++V P E +V F +++
Sbjct: 1649 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1705
Query: 400 SLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVL-TSTDSRMWIEFRSSSNWVGKGFAAVY 458
SL +D +EV DG ++S LL G E L S+ +++ I F S KGF VY
Sbjct: 1706 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1763
Query: 459 EAI 461
+A+
Sbjct: 1764 QAV 1766
Score = 50.4 bits (119), Expect = 8e-06
Identities = 35/116 (30%), Positives = 54/116 (46%), Gaps = 6/116 (5%)
Query: 346 CPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405
CPA E +S G + SPG+P+ YP+ C W +SV G I + K +D
Sbjct: 2352 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2406
Query: 406 YIEVRDGYWRKSPLLGRFCGDKLPEV-LTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
++V DG +SP+L GD +TS +++++ + KGF Y A
Sbjct: 2407 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2462
Score = 43.9 bits (102), Expect = 8e-04
Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 5/93 (5%)
Query: 909 NNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGS 968
++YP C W + E+G + + + F+ E+E +D ++++DG + + L G
Sbjct: 2372 DSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQSPVLISLSGD 2427
Query: 969 -GPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
I S G V + + D NKKGF IRY
Sbjct: 2428 YSSAFNITSNGHEVFLQWSADHGNNKKGFRIRY 2460
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sapiens]
Length = 3707
Score = 218 bits (555), Expect = 2e-56
Identities = 201/831 (24%), Positives = 329/831 (39%), Gaps = 191/831 (22%)
Query: 341 RKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIV-LNFTTMDLYKS 399
R + + CG LQ +G +SP FP Y S C+W ++ K++ +NF DL
Sbjct: 540 RPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE-- 597
Query: 400 SLCWYDYIEVRDGYWRKSP--LLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAV 457
YD + + DG P +L G +P+++ S S+MW+ ++ + GF
Sbjct: 598 --IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVN 655
Query: 458 YEAI----CGGE------IRKNEG------------------------------------ 471
Y+ I CG IR+ +G
Sbjct: 656 YKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIP 715
Query: 472 ---------------QIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCA 516
+ SP+YP+ Y C+W I + L+F F++E
Sbjct: 716 ICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ---- 771
Query: 517 YDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK-EE 575
+D+L V+DG S SP++G F G + P + S S+ L ++F +D +++ GF +
Sbjct: 772 FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGH 831
Query: 576 DECAKPD------RGG------------CEQRCLNTLGSYQCAC---EPGYELGPDRRSC 614
+EC P R G CE+ + T G+ C + C
Sbjct: 832 NECPDPGIPINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKC 891
Query: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
A CGG + +G I +PGWP Y + NC W + A + I + FE F+ E N YD
Sbjct: 892 GAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTELN----YD 947
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF------- 727
+E+ G + S L G + G +VP+ + S N + + F +DN+ S GFK H+
Sbjct: 948 VLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 1007
Query: 728 FSDKDECSKDNGGCQHECVNTMGSYMCQCRNGFVL-HDNKHDCK------------EAEC 774
+S D +G + + C +G+ L H+ C+ +A C
Sbjct: 1008 YSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALC 1067
Query: 775 EQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEV 834
+ PSG I SP +P+ YP+ CTW + T G ++ F F +E H +D+L +
Sbjct: 1068 GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HDYLLI 1123
Query: 835 FDGETEKSPILGRLCGNKIPDPLVA--TGN-KMFVRFVSDASVQRKGFQ----------- 880
+ + P L RL G+ +P + A GN + +RF+SD S+ +GF
Sbjct: 1124 TENGSFTQP-LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYNLEPC 1182
Query: 881 ---------------------ATHSTECGGRLKAESK---------------PRDLYSHA 904
T S G RL+ S+ PR +
Sbjct: 1183 EDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCVAECG 1242
Query: 905 QFGDNN------------YPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELF 952
NN Y +C + + + G + +S +TF + + D ++++
Sbjct: 1243 ASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG-----DVLKIY 1297
Query: 953 DGLDSTAVGLGRFCGSGPPE-EIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
DG D T LG F G+ + S + + + F++D +GF + Y S
Sbjct: 1298 DGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTS 1348
Score = 206 bits (523), Expect = 1e-52
Identities = 177/662 (26%), Positives = 279/662 (42%), Gaps = 144/662 (21%)
Query: 460 AICGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
A CGG + ++ G+I SP YP Y C+W I V V L F +F+ E ++D
Sbjct: 1412 AECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE----ASHD 1467
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKE-EDE 577
L V DG EN L+ G PE I ST N + ++F +D ++K+GFA F
Sbjct: 1468 ILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATA 1527
Query: 578 CAKPD------RGGCEQRCLNTLGSYQCACEPGYELGPDRRS-----------------C 614
C P R G + +T+ C+PGYEL + R C
Sbjct: 1528 CRDPGVPMNGTRNGDGREPGDTV---VFQCDPGYELQGEERITCIQVENRYFWQPSPPVC 1584
Query: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
A CGG LT +G I +P +P YP +++C W + Y IS+ F F +E N YD
Sbjct: 1585 IAPCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YD 1640
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
++ I+ G S S L G F +++PE I S N M + F+SD +VS GF + + E
Sbjct: 1641 FLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRES 1700
Query: 735 SKDNG--------GCQHECVNTMGSYMCQCRNGFVLH-----------------DNKHDC 769
D G G ++ +T+ Y C G+VL +
Sbjct: 1701 CFDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPS 1757
Query: 770 KEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAY 829
A C + G + SPN+P Y C + I A P + F +F Q +
Sbjct: 1758 CHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSI-AVPKEFV--VFGQFVF--FQTSLH 1812
Query: 830 DHLEVFDGETEKSPILGRLCGNKIPDPL-VATGNKMFVRFVSDASVQRKGFQ-------A 881
D +EV+DG T++S +L L G+ + L +++GN++ +RF S + KGF
Sbjct: 1813 DVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPR 1872
Query: 882 THSTECG-------GR---------------------------LKAESKPRDLYSHAQFG 907
T ST+C GR ++ E+ P L AQ+
Sbjct: 1873 TSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSL---AQWN 1929
Query: 908 DN--------------------------NYPGQVDCEWLLVSERGSRLELSFQTFEVEEE 941
D+ Y ++C W + G+ +++ +F E
Sbjct: 1930 DSLPTCIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH- 1988
Query: 942 ADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
+D ++ +DG D+ A LG + G+ P + S +++ ++F +D +++ GFH+ Y
Sbjct: 1989 ---NWDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYT 2045
Query: 1002 SI 1003
+I
Sbjct: 2046 AI 2047
Score = 197 bits (500), Expect = 5e-50
Identities = 154/510 (30%), Positives = 227/510 (44%), Gaps = 76/510 (14%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CGG + + G I SPN+P Y ++C W ITV+ Y + L F SF IE + YD+
Sbjct: 1586 APCGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDF 1641
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF-FKEEDEC 578
L + DG NSPLIG F PE I S+SNT+ + F SDG+V+ GF + K + C
Sbjct: 1642 LYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKAKLRESC 1701
Query: 579 AKP------DRGGCEQRCLNTLGSYQCACEPGYEL----------GPDRR--------SC 614
P R G + + +T+ Y C+ GY L G D R SC
Sbjct: 1702 FDPGNIMNGTRLGMDYKLGSTVTYY---CDAGYVLQGYSTLTCIMGDDGRPGWNRALPSC 1758
Query: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
A CG T GT+ +P +PK Y NCV+ + P ++ + +F FF + +D
Sbjct: 1759 HAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFF-----QTSLHD 1813
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVI-TSQFNNMRIEFKSDNTVSKKGFKAHFF----- 728
VE++ G + +S L G+ E + S N + I F S ++ KGF HF
Sbjct: 1814 VVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGF--HFVYQAVP 1871
Query: 729 -SDKDECS---KDNGGCQHECVNTMG-SYMCQCRNGFVLH------------------DN 765
+ +CS + G + +G S + C G++LH D+
Sbjct: 1872 RTSSTQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDS 1931
Query: 766 KHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQ 825
C C + G I SP +P+ Y + C W+I+ G I++ F E +
Sbjct: 1932 LPTC-IVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN- 1989
Query: 826 ECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHST 885
+D L+ +DG +P LG G IP L +T N +++ F SD SV GF + T
Sbjct: 1990 ---WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEY-T 2045
Query: 886 ECGGRLKAESKPRDLYSHAQFGDNNYPGQV 915
G L + +P+ S + GD G V
Sbjct: 2046 AIG--LDSCPEPQTPSSGIKIGDRYMVGDV 2073
Score = 183 bits (464), Expect = 8e-46
Identities = 141/501 (28%), Positives = 219/501 (43%), Gaps = 62/501 (12%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CG +EG + SPNYP +Y CV+ I V + + V F F+ HD
Sbjct: 1760 APCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSLHD-----V 1814
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIR-STSNTLWMKFVSDGTVNKAGFAANFFK----E 574
+EV DG ++ S L+ G E + S+ N + ++F S G + GF +
Sbjct: 1815 VEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVYQAVPRTS 1874
Query: 575 EDECAKPDRGGCEQRCLNTLG---SYQCACEPGYEL------------------GPDRRS 613
+C+ +R N S C PGY L +
Sbjct: 1875 STQCSSVPEPRFGRRIGNEFAVGSSVLFDCNPGYILHGSIAIRCETVPNSLAQWNDSLPT 1934
Query: 614 CEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKY 673
C CGG+LTK GTI +PG+P+ Y N NCVW++ P I V+ F E N +
Sbjct: 1935 CIVPCGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN----W 1990
Query: 674 DYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS-DKD 732
D ++ + G + + G + G +P ++ S NN+ + F+SD +VS GF + + D
Sbjct: 1991 DSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGLD 2050
Query: 733 ECSK---DNGGCQHECVNTMGSYMC-QCRNGFVLHDNKH-DCKE--------------AE 773
C + + G + +G + QC G+ L + H C A+
Sbjct: 2051 SCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLAQ 2110
Query: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
C + SG+I SP +P YPS +CTW I+ G + L F F E +D+LE
Sbjct: 2111 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFS----TETIHDYLE 2166
Query: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKA 893
V G +E S ++GRL G +IP L +T ++ + F SD S ++GF + +L++
Sbjct: 2167 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAY---QLQS 2223
Query: 894 ESKPRDLYSHAQFGDNNYPGQ 914
PR + G++ GQ
Sbjct: 2224 CPDPRPFRNGFVIGNDFTVGQ 2244
Score = 181 bits (458), Expect = 4e-45
Identities = 142/469 (30%), Positives = 217/469 (46%), Gaps = 64/469 (13%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CGG + G I SP +P +Y +C W I + + V L F +F E +DY
Sbjct: 2109 AQCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTET----IHDY 2164
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECA 579
LEVR G+SE S +IGR G P + ST++ + F SD + NK GF + + +
Sbjct: 2165 LEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQSC 2224
Query: 580 ---KPDRGGCEQRCLNTLG-SYQCACEPGYEL----------GPDRR------SCEAACG 619
+P R G T+G + C PGY L G R CEA CG
Sbjct: 2225 PDPRPFRNGFVIGNDFTVGQTISFECFPGYTLIGNSALTCLHGVSRNWNHPLPRCEALCG 2284
Query: 620 GLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIW 679
G +T +NGTI +PG+P EYP ++C W V P I + F + E YD++ +W
Sbjct: 2285 GNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYDFITVW 2340
Query: 680 SGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGF---------------- 723
G S G+F G E + S N + I+F SD T S GF
Sbjct: 2341 DGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFVLSYHAYQLRVCQPP 2398
Query: 724 ----KAHFFSDKDECSKDNGGCQHECV---NTMGSYMCQCRNGFVLH-DNKHDCKEAEC- 774
A ++ DE + +++C+ +G+ + CR G L D + C
Sbjct: 2399 PPVPNAEILTEDDE-FEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLCP 2457
Query: 775 --EQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
E ++ S +G+I SP +PD YP+ + C W IS G+ I + F+ E+ +D L
Sbjct: 2458 ANELRLDS-TGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVL 2512
Query: 833 EVFDGETEKSPILGRLCGN-KIPDPLVATGNKMFVRFVSDASVQRKGFQ 880
+V+DG +SP+L L G+ + + G+++F+++ +D +KGF+
Sbjct: 2513 QVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFR 2561
Score = 150 bits (379), Expect = 6e-36
Identities = 130/501 (25%), Positives = 207/501 (41%), Gaps = 63/501 (12%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
+A+CGG++R G I SP YP+ Y C W + V+ V F +F +E H +D
Sbjct: 1064 DALCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDH----HD 1119
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRS---TSNTLWMKFVSDGTVNKAGFAANFFKEE 575
YL + + S PL R G D P I + + ++F+SD +++ GF F +
Sbjct: 1120 YLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSEYN 1178
Query: 576 -DECAKPDRGGCEQRCLNTLG---SYQCACEPGYE---------LGPDRR-------SCE 615
+ C P R G + +C GY LG RR C
Sbjct: 1179 LEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPRCV 1238
Query: 616 AACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDY 675
A CG T G + +P +P Y N C++ + I++ F L +V K
Sbjct: 1239 AECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQGDVLK--- 1295
Query: 676 VEIWSGLSSESKLHGKFCGAEVPEV-ITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
I+ G + L G F GA + + ++S N + +EF SD + +GF+ + S +
Sbjct: 1296 --IYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1353
Query: 735 SKDNGGCQHEC-VNTMGSY-----MCQCRNGFVLH---------------DNKHDCKEAE 773
+D G Q ++ G + + C G+ LH D AE
Sbjct: 1354 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE 1413
Query: 774 CEQKIH-SPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
C + SG I SP +P Y + C W I PG+ + L F F+ E ++D L
Sbjct: 1414 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFD----TEASHDIL 1469
Query: 833 EVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLK 892
V+DG E +L + G+ IP+ + +T N + ++F +D + + GF S+ +
Sbjct: 1470 RVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACR 1529
Query: 893 AESKPRDLYSHAQFGDNNYPG 913
P + + GD PG
Sbjct: 1530 DPGVP---MNGTRNGDGREPG 1547
Score = 145 bits (367), Expect = 1e-34
Identities = 119/472 (25%), Positives = 201/472 (42%), Gaps = 102/472 (21%)
Query: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAP-TQYRISVKFEFFELEGNEVCKYDYV 676
CG L +GT T+P +P +Y N CVW + A T I + FE F+LE YD +
Sbjct: 548 CGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE----IGYDTL 603
Query: 677 EIWSG--LSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS-DKDE 733
I G + + G+ VP++I S + M + ++D +V GFK ++ +K+
Sbjct: 604 TIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKES 663
Query: 734 CSKDN----GGCQHECVNTMGSYMCQCRNGFVLHDNKHD-CKEAE------------CEQ 776
C G + + + +C+ GF L K C+E C
Sbjct: 664 CGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCLS 723
Query: 777 KIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFD 836
+P G + SP++P+ Y + C W I + PG RI L+F++F++E +D L V D
Sbjct: 724 NFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ----FDFLAVKD 779
Query: 837 GETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQ--------------------- 875
G++ +SPILG G ++P L + + + + F +D S+
Sbjct: 780 GDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGI 839
Query: 876 ---------------------RKGFQATHSTE-----------------------CGGRL 891
+GF T TE CGG
Sbjct: 840 PINARRFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHF 899
Query: 892 KAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVEL 951
A S + S G Y ++CEW++ +E G ++++F+ F+ E YD +E+
Sbjct: 900 SAPSGV--ILSPGWPG--YYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEV 951
Query: 952 FDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSI 1003
DG + + LG + G+ P+ ++S + + + F TD++ + GF I Y+S+
Sbjct: 952 HDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESV 1003
Score = 135 bits (340), Expect = 2e-31
Identities = 90/304 (29%), Positives = 145/304 (47%), Gaps = 46/304 (15%)
Query: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677
CGG L LNGTI +PG+P YP NC W ++A + RI + F+ F LE +YDY+
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE----EYDYLS 120
Query: 678 IWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKD 737
++ G + + G +P +TS + + SD VS GFK ++ + S
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKV-YYEELQSSSCG 179
Query: 738 NGGCQHECV------NTMGSYMCQCRNGFVLHDNKH------------------DCK-EA 772
N G + V + C G++L + C+ E
Sbjct: 180 NPGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAED 239
Query: 773 ECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
C + SG+I+SP++P++Y + +CTW I A PG I L F++F++E+ YD+L
Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYL 295
Query: 833 EVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQA--------THS 884
E+ E + P + L G IP P+++ N + + FV+D++ + +GF A TH+
Sbjct: 296 EI---EGSEPPTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 351
Query: 885 TECG 888
T G
Sbjct: 352 TSTG 355
Score = 115 bits (287), Expect = 3e-25
Identities = 87/302 (28%), Positives = 137/302 (45%), Gaps = 46/302 (15%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
EA+CGG I G I SP YPD+Y ++C W + V + + F + E YD
Sbjct: 2280 EALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEP----IYD 2335
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGF----------- 567
++ V DG +NSP IG+F G E + STSN + +KF SD T +GF
Sbjct: 2336 FITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTT--SGFFVLSYHAYQLR 2393
Query: 568 ---------AANFFKEEDECAKPDRGGCEQRCL---NTLGSYQCACEPGYELGPDRRS-- 613
A E+DE D +CL +G+ C G L D
Sbjct: 2394 VCQPPPPVPNAEILTEDDEFEIGDI--IRYQCLPGFTLVGNAILTCRLGERLQMDGAPPV 2451
Query: 614 CEAACGGLLTKLN--GTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVC 671
C+ C +L+ G I +PG+P YP + C W + Y I++ EFF+ E
Sbjct: 2452 CQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEK---- 2507
Query: 672 KYDYVEIWSGLSSES----KLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF 727
++D ++++ G + +S L G + A ITS + + +++ +D+ +KKGF+ +
Sbjct: 2508 EFDVLQVYDGPNIQSPVLISLSGDYSSA---FNITSNGHEVFLQWSADHGNNKKGFRIRY 2564
Query: 728 FS 729
+
Sbjct: 2565 IA 2566
Score = 112 bits (281), Expect = 1e-24
Identities = 82/290 (28%), Positives = 124/290 (42%), Gaps = 36/290 (12%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
CGG ++ G I+SP +P Y C W I E + + FQSF +E YDYL
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK-EEDECAK 580
+ DG + R G+ P + ST + ++ SD V+ GF + + + C
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 180
Query: 581 PD---RGGCEQRCLNTLGSYQCACEPGYEL-GPDRRSC-------------------EAA 617
P +G + + +C GY L G + +C E A
Sbjct: 181 PGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA 240
Query: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677
CGG + +G I++P +P EY N +C W +VA IS+ F F++E KYDY+E
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KYDYLE 296
Query: 678 IWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF 727
I L G +P I S N +R+ F +D+ +GF A +
Sbjct: 297 IEGSEPPTIWL----SGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 342
Score = 100 bits (250), Expect = 5e-21
Identities = 78/299 (26%), Positives = 132/299 (44%), Gaps = 68/299 (22%)
Query: 764 DNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHR-IKLAFSEFEIE 822
D++ CK C + PSG TSPN+P +Y S +C W I+A ++ I++ F EF++
Sbjct: 538 DHRPVCKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDL- 596
Query: 823 QHQECAYDHLEVFDGETEKSP--ILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQ 880
E YD L + DG P +L L G+ +PD +V+ ++M++ +D SV GF+
Sbjct: 597 ---EIGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFK 653
Query: 881 ATH----STECG--GRLKAESKPRDLYSH-------AQFG------------DNN----- 910
+ CG G + D +S+ QFG +NN
Sbjct: 654 VNYKEIEKESCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSAN 713
Query: 911 ---------------------------YPGQVDCEWLLVSERGSRLELSFQTFEVEEEAD 943
Y ++C W ++S+ GSR+ LSF F++E +
Sbjct: 714 IPICIFPCLSNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLESQ-- 771
Query: 944 CGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
+D++ + DG + LG F G+ P + S + + F D +++ +GF+I Y +
Sbjct: 772 --FDFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT 828
Score = 77.0 bits (188), Expect = 8e-14
Identities = 41/104 (39%), Positives = 59/104 (56%), Gaps = 5/104 (4%)
Query: 343 LYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSL 401
L RC A CG + NG + SPG+P+ YP++ C W V V PG I +NFT +
Sbjct: 2276 LPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI-- 2333
Query: 402 CWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRS 445
YD+I V DG + SP +G+F G+ E + ST +++ I+F S
Sbjct: 2334 --YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHS 2375
Score = 70.1 bits (170), Expect = 1e-11
Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 4/112 (3%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG + + +G + SPGFP YPS C W +++ G + L F S+ +DY+E
Sbjct: 2111 CGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNF----STETIHDYLE 2166
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
VR G S ++GR G ++P L ST + F S + +GF VY+A
Sbjct: 2167 VRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2218
Score = 68.6 bits (166), Expect = 3e-11
Identities = 39/112 (34%), Positives = 57/112 (50%), Gaps = 4/112 (3%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L S+G + SP FP+ YP C W ++V I L F + + + YD++
Sbjct: 1588 CGGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN----YDFLY 1643
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
+ DG SPL+G F KLPE + S+ + M + FRS + GF Y+A
Sbjct: 1644 IYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEYKA 1695
Score = 67.4 bits (163), Expect = 6e-11
Identities = 77/318 (24%), Positives = 109/318 (34%), Gaps = 71/318 (22%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG TL+ NG + SPGFP GYP+ +C W + +I + F + L + YDY+
Sbjct: 65 CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE----YDYLS 120
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI----CGG 464
+ DG+ + R G LP +TST S + S GF YE + CG
Sbjct: 121 LYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSSCGN 180
Query: 465 EIRKNEGQIQS--------------PNYPDDYRPMKECV--------WKITV----SESY 498
+G + Y D P C+ W V +E
Sbjct: 181 PGVPPKGVLYGTRFDVGDKIRYSCVTGYILDGHPQLTCIANSVNTASWDFPVPICRAEDA 240
Query: 499 HVG--------LTFQSFEIERHDNC-------------------------AYDYLEVRDG 525
G ++ SF E H+N YDYLE+
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEKYDYLEIEG- 299
Query: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDRGG 585
+ P G + P I S N L + FV+D GF+A + G
Sbjct: 300 ---SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHTTSTGE 356
Query: 586 CEQRCLNTLGSYQCACEP 603
E+ T G+ A P
Sbjct: 357 LEEHNRTTTGAIAVASTP 374
Score = 65.5 bits (158), Expect = 2e-10
Identities = 39/131 (29%), Positives = 68/131 (51%), Gaps = 5/131 (3%)
Query: 332 LSKGDIAQARKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLN 390
L G + + + +C A CG +G + SPG+P Y +C W + PG I +
Sbjct: 877 LMDGKVMWSGLIPKCGAPCGGHFSAPSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKIT 936
Query: 391 FTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWV 450
F + +++ L YD +EV DG SPLLG + G ++P+ L S+ + +++ F + ++
Sbjct: 937 F---ERFQTELN-YDVLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRS 992
Query: 451 GKGFAAVYEAI 461
GF YE++
Sbjct: 993 NNGFKIHYESV 1003
Score = 64.7 bits (156), Expect = 4e-10
Identities = 35/116 (30%), Positives = 59/116 (50%), Gaps = 10/116 (8%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKI---VLNFTTMDLYKSSLCWYD 405
CG L + G + SPG+P Y + +C+W+++V G I V++F T +D
Sbjct: 1939 CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN-------WD 1991
Query: 406 YIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI 461
++ DG +P LG + G +P +L ST + +++ F+S + GF Y AI
Sbjct: 1992 SLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAI 2047
Score = 63.5 bits (153), Expect = 9e-10
Identities = 38/130 (29%), Positives = 62/130 (47%), Gaps = 8/130 (6%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
ACG T++ S+G +SSP FPN Y + C W + PG+ I L FT + + YDY+
Sbjct: 240 ACGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----YDYL 295
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIR 467
E+ P G +P + S + + + F + SN +GF+A Y+
Sbjct: 296 EIEG----SEPPTIWLSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQGSSTLTHT 351
Query: 468 KNEGQIQSPN 477
+ G+++ N
Sbjct: 352 TSTGELEEHN 361
Score = 62.8 bits (151), Expect = 2e-09
Identities = 31/93 (33%), Positives = 48/93 (51%), Gaps = 4/93 (4%)
Query: 910 NYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSG 969
NYP +DC W + G + L F F E +DY+E+ G T+ +GR G
Sbjct: 2130 NYPSSLDCTWTINLPIGFGVHLQFVNFSTETI----HDYLEVRSGSSETSTVIGRLSGPQ 2185
Query: 970 PPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
P ++S ++FH+D + NK+GFHI Y++
Sbjct: 2186 IPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQA 2218
Score = 57.0 bits (136), Expect = 9e-08
Identities = 37/122 (30%), Positives = 55/122 (45%), Gaps = 9/122 (7%)
Query: 344 YRCPAC-----GETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYK 398
Y P+C G ES+G + SPG+P Y + C+W + V PG + L F D
Sbjct: 1405 YPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEA 1464
Query: 399 SSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
S +D + V DG LL G +PE + ST + + I+F + GFA +
Sbjct: 1465 S----HDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1520
Query: 459 EA 460
+
Sbjct: 1521 SS 1522
Score = 57.0 bits (136), Expect = 9e-08
Identities = 34/112 (30%), Positives = 58/112 (51%), Gaps = 10/112 (8%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG + A + +YS + YP DC WL+ G+ + ++F + E Y
Sbjct: 2283 CGGNITAMNGT--IYSPGY--PDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----Y 2334
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHI 998
D++ ++DG D + +G+F G+ E +YS + +LI FH+D T + GF +
Sbjct: 2335 DFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFV 2384
Score = 54.7 bits (130), Expect = 4e-07
Identities = 35/128 (27%), Positives = 59/128 (46%), Gaps = 12/128 (9%)
Query: 877 KGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTF 936
KGF T CGG LK + + YP +C W++++E +R+++ FQ+F
Sbjct: 59 KGFIYT----CGGTLKGLNGTIESPGFPY----GYPNGANCTWVIIAEERNRIQIVFQSF 110
Query: 937 EVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGF 996
+EEE YDY+ L+DG R G P + S + +D ++ GF
Sbjct: 111 ALEEE----YDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGF 166
Query: 997 HIRYKSIR 1004
+ Y+ ++
Sbjct: 167 KVYYEELQ 174
Score = 53.9 bits (128), Expect = 7e-07
Identities = 36/115 (31%), Positives = 55/115 (47%), Gaps = 12/115 (10%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG ++ S + S F N Y DC W +V+E G + L F F++EE+ Y
Sbjct: 241 CGGTMRGSS---GIISSPSF-PNEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK----Y 292
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
DY+E+ +G + + L G P I S + + +HF TD +GF Y+
Sbjct: 293 DYLEI-EGSEPPTIWLS---GMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Score = 53.1 bits (126), Expect = 1e-06
Identities = 41/123 (33%), Positives = 62/123 (50%), Gaps = 7/123 (5%)
Query: 341 RKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKS 399
R L C A CG S G + SP +P Y +C++ ++V P E +V F +++
Sbjct: 1753 RALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAV-PKEFVV--FGQFVFFQT 1809
Query: 400 SLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVL-TSTDSRMWIEFRSSSNWVGKGFAAVY 458
SL +D +EV DG ++S LL G E L S+ +++ I F S KGF VY
Sbjct: 1810 SL--HDVVEVYDGPTQQSSLLSSLSGSHSGESLPLSSGNQITIRFTSVGPITAKGFHFVY 1867
Query: 459 EAI 461
+A+
Sbjct: 1868 QAV 1870
Score = 50.4 bits (119), Expect = 8e-06
Identities = 35/116 (30%), Positives = 54/116 (46%), Gaps = 6/116 (5%)
Query: 346 CPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405
CPA E +S G + SPG+P+ YP+ C W +SV G I + K +D
Sbjct: 2456 CPA-NELRLDSTGVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FD 2510
Query: 406 YIEVRDGYWRKSPLLGRFCGDKLPEV-LTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
++V DG +SP+L GD +TS +++++ + KGF Y A
Sbjct: 2511 VLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA 2566
Score = 43.9 bits (102), Expect = 8e-04
Identities = 27/93 (29%), Positives = 45/93 (48%), Gaps = 5/93 (5%)
Query: 909 NNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGS 968
++YP C W + E+G + + + F+ E+E +D ++++DG + + L G
Sbjct: 2476 DSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----FDVLQVYDGPNIQSPVLISLSGD 2531
Query: 969 -GPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
I S G V + + D NKKGF IRY
Sbjct: 2532 YSSAFNITSNGHEVFLQWSADHGNNKKGFRIRY 2564
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 213 bits (541), Expect = 1e-54
Identities = 189/683 (27%), Positives = 282/683 (41%), Gaps = 159/683 (23%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
C ++ G ++SP +P Y C W IT E + + L FQSF +E +D L
Sbjct: 26 CTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEED----FDVLS 81
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF-FKEEDECAK 580
V DG + L R G+ P I S + TL ++ +SD V+ GF A + C
Sbjct: 82 VFDGPPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGN 141
Query: 581 PDR--GGCEQRCLNTLGS---YQC------------ACEPGYELGP----DRRSCEA--A 617
P R G +Q LG Y C C G E SC A A
Sbjct: 142 PGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPSCRADDA 201
Query: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677
CGG L +G I++P +P EY N +C W ++A I++ F F+LE YD++E
Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDFLE 257
Query: 678 IWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKD 737
+ +G S F GA +P + S N +R+ F SD ++GF A + K K
Sbjct: 258 V-TGTEGSSLW---FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKS 313
Query: 738 NG--------GCQHECVNT-----MGSYMC------------------------QCRNGF 760
G Q V T G MC C G+
Sbjct: 314 RGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGY 373
Query: 761 VLH------------------DNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTW 802
L D++ C+ C+ + PSG+ITSPN+P +Y + C W
Sbjct: 374 DLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVW 433
Query: 803 EISA-TPGHRIKLAFSEFEIEQHQECAYDHLEVFDG--ETEKSPILGRLCGNKIPDPLVA 859
I+A P IKLAF EF++E+ YD L V DG + ++ +L L G +PD +V+
Sbjct: 434 IITALNPSKVIKLAFEEFDLER----GYDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVS 489
Query: 860 TGNKMFVRFVSDASVQRKGFQATHST----ECG-------GR-----------LKAESKP 897
T ++M++ F +D S GF+A++ CG GR LK E +P
Sbjct: 490 TNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQP 549
Query: 898 --------------RDLYSHAQFG-----------------DNNYP----GQVDCEWLLV 922
+ +S + G NYP + C WL++
Sbjct: 550 AFELVGQKAITCQKNNQWSAKKPGCVFSCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLIL 609
Query: 923 SERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVL 982
+ SR+ L+F +VE + +D++ + DG + A LG F G+ P I S G
Sbjct: 610 ARPESRIHLAFNDIDVEPQ----FDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVAR 665
Query: 983 IHFHTDDTINKKGFHIRYKSIRY 1005
+ F TD + K+GF+I + + R+
Sbjct: 666 LEFQTDHSTGKRGFNITFTTFRH 688
Score = 202 bits (513), Expect = 2e-51
Identities = 169/652 (25%), Positives = 268/652 (41%), Gaps = 124/652 (19%)
Query: 460 AICGGEIRKN-EGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
A CGG +R GQ+ SP YP Y C+W I +GL F F+ E +D
Sbjct: 1269 AECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEE----VHD 1324
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF-FKEEDE 577
L + DG E+ L+ G P+D+ ST N++ ++F +D +K GFA F
Sbjct: 1325 VLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATS 1384
Query: 578 CAKPDRGGCEQRCLNTLGSYQCA------CEPGYELG-----------------PDRRSC 614
C P G Q + S++ C+PGY L P +C
Sbjct: 1385 CNDP---GIPQNGSRSGDSWEAGDSTVFQCDPGYALQGSAEISCVKIENRFFWQPSPPTC 1441
Query: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
A CGG LT +G I +P +P+ YPP K C W+V Y I++ F F LE YD
Sbjct: 1442 IAPCGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPG----YD 1497
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
++ I+ G S S L G F G+++P I S N++ + F+SD +VS GF + + E
Sbjct: 1498 FLHIYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDYTENPRES 1557
Query: 735 SKDNGGCQ-------------------HECVNTMGSYMCQC---RNGFVLHDNKHDCKEA 772
D G + H G+ C +G + +N A
Sbjct: 1558 CFDPGSIKNGTRVGSDLKLGSSVTYYCHGGYEVEGTSTLSCILGPDGKPVWNNPRPVCTA 1617
Query: 773 ECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
C + G++ SPN+P Y S + C + ++ + + F+ F + D +
Sbjct: 1618 PCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALN-----DVV 1672
Query: 833 EVFDGETEKSPILGRLCGNKIPDPL-VATGNKMFVRFVSDASVQRKGFQ-------ATHS 884
EV DG ++ S +L L G+ + L +AT N++ ++F + +GF T +
Sbjct: 1673 EVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVPRTSA 1732
Query: 885 TEC--------GGRLKAESKPRDLY-----------------------SHAQFGDNNYPG 913
T+C G RL ++ + + AQ+ +
Sbjct: 1733 TQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVSAPTC 1792
Query: 914 QVDCEWLLVSERGSRLELSF----------------------QTFEVEEEADCGYDYVEL 951
V C L RG+ L F Q V + +D +E+
Sbjct: 1793 VVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQNWDSLEV 1852
Query: 952 FDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSI 1003
FDG D+T LG F G+ P + S + + +HF++D +++ GFH+ YK++
Sbjct: 1853 FDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTV 1904
Score = 200 bits (509), Expect = 5e-51
Identities = 135/468 (28%), Positives = 219/468 (46%), Gaps = 55/468 (11%)
Query: 461 ICGGEIRKNEGQIQSPNYPDDYRPMKECVWKIT-VSESYHVGLTFQSFEIERHDNCAYDY 519
+C +R G I SPN+P Y CVW IT ++ S + L F+ F++ER YD
Sbjct: 404 MCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLER----GYDT 459
Query: 520 LEVRDG--TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK-EED 576
L V DG + ++ G P+ I ST++ +W+ F +DG+ + GF A++ + E+
Sbjct: 460 LTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQG 519
Query: 577 ECAKPD------RGGCE-----------QRCLNTLGSYQCACEPGYELGPDRRSCEAACG 619
C P R G Q +G C+ + + C +C
Sbjct: 520 SCGDPGIPAYGRREGSRFHHGDTLKFECQPAFELVGQKAITCQKNNQWSAKKPGCVFSCF 579
Query: 620 GLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIW 679
T +G + +P +P++Y + +CVW ++A + RI + F ++E ++D++ I
Sbjct: 580 FNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEP----QFDFLVIK 635
Query: 680 SGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNG 739
G ++E+ + G F G ++P ITS + R+EF++D++ K+GF F + + D G
Sbjct: 636 DGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNECPDPG 695
Query: 740 G--------------------CQHECVNTMGSYMCQC--RNGFVLHDNKHDCKEAECEQK 777
C + T GS C + G V+ ++ EA C
Sbjct: 696 VPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGH 755
Query: 778 IHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDG 837
+ SPSG I SP WP Y C W I A PG+ IK+ F F+ E + YD LEV DG
Sbjct: 756 LTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVN----YDTLEVRDG 811
Query: 838 ETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHST 885
T +P++G G ++P L++T N +++ F +D S GFQ + T
Sbjct: 812 RTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYET 859
Score = 196 bits (497), Expect = 1e-49
Identities = 176/688 (25%), Positives = 274/688 (39%), Gaps = 165/688 (23%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
CGG + + G I SP +P+ Y CVWKI V E + + SF E++ +D LE
Sbjct: 1796 CGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN----WDSLE 1851
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF----FKEEDE 577
V DG ++G F G P + STSN L++ F SD +V+ AGF + E
Sbjct: 1852 VFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTVGLSSCPE 1911
Query: 578 CAKPDRG--GCEQRCLNTLGSYQCACEPGYEL----------GPDRR------SCEAACG 619
A P G E+ +N + S+QC EPGY L G RR C A CG
Sbjct: 1912 PAVPSNGVKTGERYLVNDVVSFQC--EPGYALQGHAHISCMPGTVRRWNYPPPLCIAQCG 1969
Query: 620 GLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIW 679
G + ++ G I +PG+P YP N +C W++ P + ++F F E N +DY+EI
Sbjct: 1970 GTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN----HDYIEIR 2025
Query: 680 SGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS---------- 729
+G S++ G+F G+E+P + S + + F SD++ ++ GFK +
Sbjct: 2026 NGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQISSF 2085
Query: 730 ----DKDECSKDNG--------------GCQ----HEC---------------VNTMGSY 752
D E + N GC+ EC N S
Sbjct: 2086 LRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAGYNVGQSV 2145
Query: 753 MCQCRNGFVL---------------HDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSR 797
+C G+ L D+ E C I S +G + SP +P Y S
Sbjct: 2146 TFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSPYSSS 2205
Query: 798 KECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPL 857
++C W I+ GH ++L S + E + D + ++DG + +P LG + +
Sbjct: 2206 QDCVWLITVPIGHGVRLNLSLLQTEP----SGDFITIWDGPQQTAPRLGVFTRSMAKKTV 2261
Query: 858 VATGNKMFVRFVSDAS---VQRKGFQATHSTEC--------------------------- 887
++ N++ ++F DA+ + F A T+C
Sbjct: 2262 QSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIGDIVRYR 2321
Query: 888 -----------------GGRLKAESKPRDLYSHAQFGD-----------NNYPGQV---- 915
G L+ E P H + +YPG
Sbjct: 2322 CLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQ 2381
Query: 916 DCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGS-GPPEEI 974
C WL+ E + L+ + F E++ YD E+FDG + L G+ P +
Sbjct: 2382 TCSWLVRVEPDYNISLTVEYFLSEKQ----YDEFEIFDGPSGQSPLLKALSGNYSAPLIV 2437
Query: 975 YSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
S +SV + + +D N+KGF IRY +
Sbjct: 2438 TSSSNSVYLRWSSDHAYNRKGFKIRYSA 2465
Score = 191 bits (486), Expect = 2e-48
Identities = 177/667 (26%), Positives = 278/667 (41%), Gaps = 125/667 (18%)
Query: 441 IEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHV 500
I + ++ W K V+ C G + SPNYP+DY CVW I +
Sbjct: 559 ITCQKNNQWSAKKPGCVFS--CFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRI 616
Query: 501 GLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDG 560
L F ++E +D+L ++DG + +P++G F G P I S+ + ++F +D
Sbjct: 617 HLAFNDIDVEPQ----FDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDH 672
Query: 561 TVNKAGFAANFFK-EEDECAKPD------RGG------------CEQRCLNTLGSYQCAC 601
+ K GF F +EC P R G C++ L T GS C
Sbjct: 673 STGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCDEGFLGTQGSETITC 732
Query: 602 ---EPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISV 658
E CEA CGG LT +GTI +PGWP Y +C W + A Y I +
Sbjct: 733 VLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKI 792
Query: 659 KFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTV 718
F+ F+ E N YD +E+ G + + L G + G +VP+ + S N + + F +D +
Sbjct: 793 TFDRFKTEVN----YDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSH 848
Query: 719 SKKGFKAHFFS---DKDECSKDN---GGCQHECVNTMGSYMC-QCRNGFVLHDNKH-DCK 770
S GF+ + + D C G +H +G+ + C +G+ L D + +C+
Sbjct: 849 SDIGFQLRYETITLQSDHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECE 908
Query: 771 ------------EAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSE 818
EA C I SG I SP +PD YP+ CTW I + G + F
Sbjct: 909 PNFQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHT 968
Query: 819 FEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMF---VRFVSDASVQ 875
F H E +D+L + + + P L +L G+++P P+ A F VRF+SD S+
Sbjct: 969 F----HLESGHDYLLITENGSFTQP-LRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMS 1023
Query: 876 --------------------------RKGFQ------ATHSTECGGRLKAESK------P 897
RKG Q T S G RL+ ++
Sbjct: 1024 YEGFNITFSEYDLEPCEEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGR 1083
Query: 898 RDLYSH------AQFGDN---------------NYPGQVDCEWLLVSERGSRLELSFQTF 936
R L+S A+ G++ NY +C + + ++ G ++L + F
Sbjct: 1084 RRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAF 1143
Query: 937 EVEEEADCGYDYVELFDGLDSTAVGLGRFCGSG-PPEEIYSIGDSVLIHFHTDDTINKKG 995
E+ E D ++++DG +++A LG F S + S S+ + F TD KG
Sbjct: 1144 ELSEG-----DVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKG 1198
Query: 996 FHIRYKS 1002
F + + S
Sbjct: 1199 FELHFSS 1205
Score = 179 bits (453), Expect = 2e-44
Identities = 135/472 (28%), Positives = 211/472 (44%), Gaps = 63/472 (13%)
Query: 457 VYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCA 516
V A CGG+ ++G + SPNYP +Y + C++ +TV + Y V F F +D
Sbjct: 1614 VCTAPCGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTVPKDYVVFGQFAFFHTALND--- 1670
Query: 517 YDYLEVRDGTSENSPLIGRFCGYDKPEDIR-STSNTLWMKFVSDGTVNKAGFAANFFKEE 575
+EV DG S++S L+ G E + +TSN + +KF + G GF +
Sbjct: 1671 --VVEVHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAVP 1728
Query: 576 DECAKPDRGGCEQRCLNTLGS-------YQCACEPGYEL------------------GPD 610
A E R LGS + C GY L
Sbjct: 1729 RTSATQCSSVPEPRYGKRLGSDFSVGAIVRFECNSGYALQGSPEIECLPVPGALAQWNVS 1788
Query: 611 RRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEV 670
+C CGG LT+ GTI +PG+P+ Y + NCVW++V P I ++ F E N
Sbjct: 1789 APTCVVPCGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN-- 1846
Query: 671 CKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF--- 727
+D +E++ G + + G F G VP ++ S N + + F SD +VS GF +
Sbjct: 1847 --WDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTV 1904
Query: 728 -FSDKDECSKDNGGC---QHECVNTMGSYMCQCRNGFVLHDNKH-DCKE----------- 771
S E + + G + VN + S+ QC G+ L + H C
Sbjct: 1905 GLSSCPEPAVPSNGVKTGERYLVNDVVSF--QCEPGYALQGHAHISCMPGTVRRWNYPPP 1962
Query: 772 ---AECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECA 828
A+C + G+I SP +P YPS +C+W+I+ G + F F E +
Sbjct: 1963 LCIAQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN---- 2018
Query: 829 YDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQ 880
+D++E+ +G E S ++GR G+++P L++T ++ V F SD S R GF+
Sbjct: 2019 HDYIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFK 2070
Score = 175 bits (444), Expect = 2e-43
Identities = 168/645 (26%), Positives = 268/645 (41%), Gaps = 119/645 (18%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
EA CGG + G I SP +P Y+ C W I Y + +TF F+ E + YD
Sbjct: 749 EAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTEVN----YD 804
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK---EE 575
LEVRDG + ++PLIG + G P+ + STSN L++ F +D + + GF + +
Sbjct: 805 TLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRYETITLQS 864
Query: 576 DECAKPDRGGCEQRCLN-----TLGSYQC------------ACEPGYELGPDRRSCEAAC 618
D C P QR N L ++ C CEP ++ SCEA C
Sbjct: 865 DHCLDPGIPVNGQRHGNDFYVGALVTFSCDSGYTLSDGEPLECEPNFQWSRALPSCEALC 924
Query: 619 GGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEI 678
GG + +GTI +PG+P YP N NC W + + F F LE +DY+ I
Sbjct: 925 GGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESG----HDYLLI 980
Query: 679 WSGLSSESKLHGKFCGAEVPEVITS-QFNNM--RIEFKSDNTVSKKGFKAHFFS-DKDEC 734
S L + G+ +P I++ + N ++ F SD ++S +GF F D + C
Sbjct: 981 TENGSFTQPLR-QLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNITFSEYDLEPC 1039
Query: 735 SKD-------NGGCQHECVNTM-----------GSYMCQCRNG-FVLHDNKHDCKEAECE 775
+ G Q +T+ G+ C G L + AEC
Sbjct: 1040 EEPEVPAYSIRKGLQFGVGDTLTFSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECG 1099
Query: 776 QKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVF 835
+ G + SPN+P Y + EC + I PG I+L FE+ + D L+V+
Sbjct: 1100 NSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEG-----DVLKVY 1154
Query: 836 DGETEKSPILGRLCGNKIPD-PLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAE 894
DG + +LG +++ L +T + +++ F++DA KGF+ S+ +K E
Sbjct: 1155 DGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSS--FELIKCE 1212
Query: 895 SKPRDLYSHAQFGDNNYPG---QVDCE--------------------W-----LLVSERG 926
+ + + ++ G C+ W V+E G
Sbjct: 1213 DPGTPKFGYKVHDEGHFAGSSVSFSCDPGYSLRGSEELLCLSGERRTWDRPLPTCVAECG 1272
Query: 927 S--RLELSFQT----------------FEVEEEADCG-------------YDYVELFDGL 955
R E+S Q + +E EA C +D + ++DG
Sbjct: 1273 GTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIWDGP 1332
Query: 956 DSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
+ V L G P++++S +SV++ F TD +K+GF I++
Sbjct: 1333 VESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQF 1377
Score = 167 bits (423), Expect = 5e-41
Identities = 135/513 (26%), Positives = 216/513 (42%), Gaps = 102/513 (19%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CGG + + EG I SP +P +Y +C WKI + + + F +F E + +DY
Sbjct: 1966 AQCGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN----HDY 2021
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGF------------ 567
+E+R+G E S ++GRF G + P + STS+ + F SD + N+ GF
Sbjct: 2022 IEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSHQ 2081
Query: 568 ----------------------AANFFKEED---------ECAKPD---RGGCEQRCLNT 593
AA++ + D EC P+ G N
Sbjct: 2082 ISSFLRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQECPDPEPFANGIVRGAGYNV 2141
Query: 594 LGSYQCACEPGYEL----------GPDRR------SCEAACGGLLTKLNGTITTPGWPKE 637
S C PGY+L G +R CE CGG +T NGT+ +PG+P
Sbjct: 2142 GQSVTFECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVPCGGNITSSNGTVYSPGFPSP 2201
Query: 638 YPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEV 697
Y +++CVW + P + + + + E + D++ IW G + G F +
Sbjct: 2202 YSSSQDCVWLITVPIGHGVRLNLSLLQTEPSG----DFITIWDGPQQTAPRLGVFTRSMA 2257
Query: 698 PEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS--DKDEC------SKDNGGCQHECVNTM 749
+ + S N + ++F D + G A FS +C ++E N
Sbjct: 2258 KKTVQSSSNQVLLKFHRD--AATGGIFAIAFSAYPLTKCPPPTILPNAEVVTENEEFNIG 2315
Query: 750 GSYMCQCRNGFVLHDNK-HDCKEAECEQ--------KIHSP--------SGLITSPNWPD 792
+C GF L N+ CK Q ++H P +G+I S ++P
Sbjct: 2316 DIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPPPICEVHCPTNELLTDSTGVILSQSYPG 2375
Query: 793 KYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGN- 851
YP + C+W + P + I L F E+ YD E+FDG + +SP+L L GN
Sbjct: 2376 SYPQFQTCSWLVRVEPDYNISLTVEYFLSEKQ----YDEFEIFDGPSGQSPLLKALSGNY 2431
Query: 852 KIPDPLVATGNKMFVRFVSDASVQRKGFQATHS 884
P + ++ N +++R+ SD + RKGF+ +S
Sbjct: 2432 SAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYS 2464
Score = 166 bits (419), Expect = 1e-40
Identities = 169/689 (24%), Positives = 262/689 (38%), Gaps = 177/689 (25%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
CGG +R G I SP++P +Y +C W I + L F F++E YD+LE
Sbjct: 202 CGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLED----GYDFLE 257
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF---------- 571
V +E S L F G P + S+ N L + F SDG + GF+A +
Sbjct: 258 VTG--TEGSSLW--FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIELKS 313
Query: 572 -----FKEEDECAK---------------------PDRGGCEQRCLNTLGSYQCACEPGY 605
+D K P+RG S Q C GY
Sbjct: 314 RGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQFTCNEGY 373
Query: 606 ELGPDRRS------------------CEAA-CGGLLTKLNGTITTPGWPKEYPPNKNCVW 646
+L +R C A C L +G IT+P +P +Y N +CVW
Sbjct: 374 DLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVW 433
Query: 647 QVVAPTQYR-ISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFC--GAEVPEVITS 703
+ A + I + FE F+LE YD + + G + + G VP++I S
Sbjct: 434 IITALNPSKVIKLAFEEFDLERG----YDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVS 489
Query: 704 QFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNG----------------GCQHEC-- 745
+ M + F++D + S GFKA + + D G + EC
Sbjct: 490 TNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYGRREGSRFHHGDTLKFECQP 549
Query: 746 -VNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEI 804
+G C+ K C + C SPSG++ SPN+P+ Y + C W I
Sbjct: 550 AFELVGQKAITCQKNNQWSAKKPGCVFS-CFFNFTSPSGVVLSPNYPEDYGNHLHCVWLI 608
Query: 805 SATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIP---------- 854
A P RI LAF++ ++E +D L + DG T ++P+LG GN++P
Sbjct: 609 LARPESRIHLAFNDIDVEPQ----FDFLVIKDGATAEAPVLGTFSGNQLPSSITSSGHVA 664
Query: 855 ----------------------------DPLVATGNKMF---------VRFVSDASVQRK 877
DP V K F + F+ D +
Sbjct: 665 RLEFQTDHSTGKRGFNITFTTFRHNECPDPGVPVNGKRFGDSLQLGSSISFLCD-----E 719
Query: 878 GFQATHSTE-----------------------CGGRLKAESKPRDLYSHAQFGDNNYPGQ 914
GF T +E CGG L + S F Y
Sbjct: 720 GFLGTQGSETITCVLKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGF----YKDA 775
Query: 915 VDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEI 974
+ C W++ ++ G ++++F F+ E YD +E+ DG +A +G + G+ P+ +
Sbjct: 776 LSCAWVIEAQPGYPIKITFDRFKTE----VNYDTLEVRDGRTYSAPLIGVYHGTQVPQFL 831
Query: 975 YSIGDSVLIHFHTDDTINKKGFHIRYKSI 1003
S + + + F TD + + GF +RY++I
Sbjct: 832 ISTSNYLYLLFSTDKSHSDIGFQLRYETI 860
Score = 117 bits (293), Expect = 5e-26
Identities = 100/367 (27%), Positives = 153/367 (41%), Gaps = 43/367 (11%)
Query: 612 RSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVC 671
RS C L NGT+ +PG+P YP NC W + A Q+RI + F+ F LE +
Sbjct: 20 RSAGQNCTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEED--- 76
Query: 672 KYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF-FSD 730
+D + ++ G L + G ++P I S + + SD VS +GF A +
Sbjct: 77 -FDVLSVFDGPPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLP 135
Query: 731 KDECSK----DNGGCQHECVNTMGSYMCQCRNGFVLHDNK------------------HD 768
C NG Q N C GF L +
Sbjct: 136 SHTCGNPGRLPNGIQQGSTFNLGDKVRYSCNLGFFLEGHAVLTCHAGSENSATWDFPLPS 195
Query: 769 CK-EAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQEC 827
C+ + C + SG+I+SP++P +Y + +CTW I A G I L F +F++E
Sbjct: 196 CRADDACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLED---- 251
Query: 828 AYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTEC 887
YD LEV TE S + G +P P++++ N + + F SD + +++GF A + +
Sbjct: 252 GYDFLEVTG--TEGSSLW--FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKK 307
Query: 888 GGRLKAE------SKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQT-FEVEE 940
LK+ SK + G C + ERG RL F+ V+
Sbjct: 308 QIELKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSVQF 367
Query: 941 EADCGYD 947
+ GYD
Sbjct: 368 TCNEGYD 374
Score = 104 bits (260), Expect = 4e-22
Identities = 81/294 (27%), Positives = 122/294 (41%), Gaps = 34/294 (11%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
E CGG I + G + SP +P Y ++CVW ITV + V L + E + D
Sbjct: 2179 EVPCGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEP----SGD 2234
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
++ + DG + +P +G F + ++S+SN + +KF D A +C
Sbjct: 2235 FITIWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAATGGIFAIAFSAYPLTKC 2294
Query: 579 AKPD-----RGGCEQRCLNTLGSYQCACEPGYEL-----------------GPDRRSCEA 616
P E N + C PG+ L GP CE
Sbjct: 2295 PPPTILPNAEVVTENEEFNIGDIVRYRCLPGFTLVGNEILTCKLGTYLQFEGPP-PICEV 2353
Query: 617 AC--GGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
C LLT G I + +P YP + C W V Y IS+ E+F E +YD
Sbjct: 2354 HCPTNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYFLSEK----QYD 2409
Query: 675 YVEIWSGLSSESKLHGKFCG-AEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF 727
EI+ G S +S L G P ++TS N++ + + SD+ ++KGFK +
Sbjct: 2410 EFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRY 2463
Score = 75.1 bits (183), Expect = 3e-13
Identities = 38/111 (34%), Positives = 57/111 (51%), Gaps = 4/111 (3%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG T++E G + SPGFP YPS C W++++ G + F + +DYIE
Sbjct: 1968 CGGTVEEMEGVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN----HDYIE 2023
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYE 459
+R+G + S ++GRF G +LP L ST + F S + GF Y+
Sbjct: 2024 IRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQ 2074
Score = 74.3 bits (181), Expect = 5e-13
Identities = 43/131 (32%), Positives = 67/131 (51%), Gaps = 5/131 (3%)
Query: 332 LSKGDIAQARKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLN 390
L +G + + RC A CG L +G + SPG+P Y C W + PG I +
Sbjct: 734 LKEGSVVWNSAVLRCEAPCGGHLTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKIT 793
Query: 391 FTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWV 450
F D +K+ + YD +EVRDG +PL+G + G ++P+ L ST + +++ F + +
Sbjct: 794 F---DRFKTEVN-YDTLEVRDGRTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHS 849
Query: 451 GKGFAAVYEAI 461
GF YE I
Sbjct: 850 DIGFQLRYETI 860
Score = 69.7 bits (169), Expect = 1e-11
Identities = 37/110 (33%), Positives = 57/110 (51%), Gaps = 4/110 (3%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L +G + SP +P YP C W+V+V+P I L F +L YD++
Sbjct: 1445 CGGDLTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEPG----YDFLH 1500
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
+ DG SPL+G F G +LP + S+ + +++ FRS ++ GF Y
Sbjct: 1501 IYDGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDY 1550
Score = 65.1 bits (157), Expect = 3e-10
Identities = 34/113 (30%), Positives = 57/113 (50%), Gaps = 4/113 (3%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L E G + SPGFP Y + +C+W++ V G I + + ++ +D +E
Sbjct: 1796 CGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN----WDSLE 1851
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI 461
V DG +LG F G +P +L ST +++++ F S + GF Y+ +
Sbjct: 1852 VFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTV 1904
Score = 65.1 bits (157), Expect = 3e-10
Identities = 30/96 (31%), Positives = 48/96 (50%), Gaps = 4/96 (4%)
Query: 910 NYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSG 969
NYP +DC W + G + F F E +DY+E+ +G T+ +GRF GS
Sbjct: 1987 NYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN----HDYIEIRNGPYETSRMMGRFSGSE 2042
Query: 970 PPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRY 1005
P + S ++FH+D + N+ GF + Y+ + Y
Sbjct: 2043 LPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTY 2078
Score = 64.7 bits (156), Expect = 4e-10
Identities = 30/107 (28%), Positives = 58/107 (54%), Gaps = 4/107 (3%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
+C +G + SP +P Y ++ HC+W + P +I L F +D+ +D++
Sbjct: 577 SCFFNFTSPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEPQ----FDFL 632
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGF 454
++DG ++P+LG F G++LP +TS+ +EF++ + +GF
Sbjct: 633 VIKDGATAEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGF 679
Score = 62.8 bits (151), Expect = 2e-09
Identities = 38/124 (30%), Positives = 63/124 (50%), Gaps = 7/124 (5%)
Query: 341 RKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRV-SVTPGEKIVLNFTTMDLYKS 399
R + R C L+ +G ++SP FP Y + HC+W + ++ P + I L F DL +
Sbjct: 397 RPVCRARMCDAHLRGPSGIITSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLERG 456
Query: 400 SLCWYDYIEVRDG--YWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAV 457
YD + V DG + +L G +P+++ ST+ +MW+ F++ + GF A
Sbjct: 457 ----YDTLTVGDGGQDGDQKTVLYILTGTSVPDLIVSTNHQMWLLFQTDGSGSSLGFKAS 512
Query: 458 YEAI 461
YE I
Sbjct: 513 YEEI 516
Score = 62.4 bits (150), Expect = 2e-09
Identities = 40/134 (29%), Positives = 59/134 (44%), Gaps = 8/134 (5%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
C L NG + SPGFP GYP+Y +C W ++ +I L F + L + +D +
Sbjct: 26 CTFQLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEED----FDVLS 81
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI----CGG 464
V DG + L R G +LP + S + + + S +GF A YE + CG
Sbjct: 82 VFDGPPQPENLRTRLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYEVLPSHTCGN 141
Query: 465 EIRKNEGQIQSPNY 478
R G Q +
Sbjct: 142 PGRLPNGIQQGSTF 155
Score = 59.3 bits (142), Expect = 2e-08
Identities = 38/114 (33%), Positives = 57/114 (50%), Gaps = 7/114 (6%)
Query: 343 LYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSL 401
L RC A CG ++ + G L SP FP Y + CI+ + PG+ I L +L +
Sbjct: 1091 LPRCVAECGNSVTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEG-- 1148
Query: 402 CWYDYIEVRDGYWRKSPLLGRFCGDKLPEV-LTSTDSRMWIEFRSSSNWVGKGF 454
D ++V DG + LLG F ++ V L ST S +W++F + + KGF
Sbjct: 1149 ---DVLKVYDGNNNSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGF 1199
Score = 58.5 bits (140), Expect = 3e-08
Identities = 33/112 (29%), Positives = 56/112 (50%), Gaps = 5/112 (4%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG + SNG + SPGFP+ Y S C+W ++V G + LN + + S D+I
Sbjct: 2182 CGGNITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSG----DFIT 2237
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
+ DG + +P LG F + + S+ +++ ++F + G FA + A
Sbjct: 2238 IWDGPQQTAPRLGVFTRSMAKKTVQSSSNQVLLKFHRDAA-TGGIFAIAFSA 2288
Score = 56.6 bits (135), Expect = 1e-07
Identities = 38/116 (32%), Positives = 57/116 (49%), Gaps = 6/116 (5%)
Query: 346 CPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405
CP E L +S G + S +P YP + C W V V P I L T++ + S YD
Sbjct: 2355 CPT-NELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISL---TVEYFLSEK-QYD 2409
Query: 406 YIEVRDGYWRKSPLLGRFCGD-KLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
E+ DG +SPLL G+ P ++TS+ + +++ + S + KGF Y A
Sbjct: 2410 EFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSA 2465
Score = 55.5 bits (132), Expect = 3e-07
Identities = 36/116 (31%), Positives = 53/116 (45%), Gaps = 16/116 (13%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
ACG TL+ +G +SSP FP+ Y + C W + G+ I L F L YD++
Sbjct: 201 ACGGTLRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLEDG----YDFL 256
Query: 408 EVR----DGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYE 459
EV W F G LP + S+ + + + F S N +GF+A Y+
Sbjct: 257 EVTGTEGSSLW--------FTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQ 304
Score = 51.6 bits (122), Expect = 4e-06
Identities = 37/117 (31%), Positives = 56/117 (47%), Gaps = 6/117 (5%)
Query: 341 RKLYRCPA-CGETLQ-ESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYK 398
R L C A CG T++ E +G + SPG+P Y +CIW + G I L+F D +
Sbjct: 1262 RPLPTCVAECGGTVRGEVSGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEE 1321
Query: 399 SSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFA 455
+D + + DG LL G LP+ L ST + + ++F + +GFA
Sbjct: 1322 V----HDVLRIWDGPVESGVLLKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFA 1374
Score = 50.1 bits (118), Expect = 1e-05
Identities = 29/96 (30%), Positives = 49/96 (51%), Gaps = 6/96 (6%)
Query: 340 ARKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYK 398
+R L C A CG +Q S+G + SPGFP+ YP+ +C W + + G+ + F T L
Sbjct: 914 SRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLES 973
Query: 399 SSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTS 434
+DY+ + + P L + G +LP +++
Sbjct: 974 G----HDYLLITENGSFTQP-LRQLTGSRLPAPISA 1004
Score = 47.0 bits (110), Expect = 9e-05
Identities = 35/114 (30%), Positives = 58/114 (50%), Gaps = 6/114 (5%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG S+G + SP +P Y S C++ V+V P + +V F + ++L D +E
Sbjct: 1619 CGGQYVGSDGVVLSPNYPQNYTSGQICLYFVTV-PKDYVV--FGQFAFFHTAL--NDVVE 1673
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVL-TSTDSRMWIEFRSSSNWVGKGFAAVYEAI 461
V DG+ + S LL G E L +T +++ I+F + +GF VY+A+
Sbjct: 1674 VHDGHSQHSRLLSSLSGSHTGESLPLATSNQVLIKFSAKGLAPARGFHFVYQAV 1727
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 207 bits (528), Expect = 3e-53
Identities = 179/656 (27%), Positives = 283/656 (43%), Gaps = 132/656 (20%)
Query: 460 AICGGEIRK-NEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
A CGG+I G+I SP YP Y C W I + L F F+ E A+D
Sbjct: 1276 AECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEM----AHD 1331
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKE-EDE 577
L+V DG ++ L+ + G PEDI ST N+L ++F SD ++K+GF+ F
Sbjct: 1332 ILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAAT 1391
Query: 578 CAKPD------RGGCEQRCLNTLGSYQCACEPGYELG-----------------PDRRSC 614
C P R G + +T+ ++QC +PGY+L PD +C
Sbjct: 1392 CNDPGMPQNGTRYGDSREAGDTV-TFQC--DPGYQLQGQAKITCVQLNNRFFWQPDPPTC 1448
Query: 615 EAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
AACGG LT G I +P +P+ YPP K C W+V + I++ F+ F +E + YD
Sbjct: 1449 IAACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPS----YD 1504
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
++ I+ G S S L G + G++ PE I S N++ + F+SD +V GF F E
Sbjct: 1505 FLHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFKEKPREA 1564
Query: 735 SKDNGGCQHEC-VNT---MGSYMC-QCRNGF-VLHDNKHDCK----------------EA 772
D G + V T +GS + QC +G+ +L + C A
Sbjct: 1565 CFDPGNIMNGTRVGTDFKLGSTITYQCDSGYKILDPSSITCVIGADGKPSWDQVLPSCNA 1624
Query: 773 ECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHL 832
C + G++ SPN+P Y + + C + I+ + F+ F Q D
Sbjct: 1625 PCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYF-----QTALNDLA 1679
Query: 833 EVFDGETEKSPILGRLCGNKIPDPL-VATGNKMFVRFVSDASVQRKGFQ-------ATHS 884
E+FDG ++ +L L G+ + L +AT N++ +RF + + +GF T
Sbjct: 1680 ELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTSD 1739
Query: 885 TEC------------------GGRLKAESKPRDLY-------------SHAQFGDN---- 909
T+C G ++ E P L + AQ+ D
Sbjct: 1740 TQCSSVPEPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWNDTIPSC 1799
Query: 910 ------------------NYP----GQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYD 947
YP ++C W ++ GS +++ +F E+ +D
Sbjct: 1800 VVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQ----NWD 1855
Query: 948 YVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSI 1003
+E+ DG D TA LG F G+ P + S + + +HF +D ++ GFH+ YK++
Sbjct: 1856 SLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTV 1911
Score = 206 bits (524), Expect = 9e-53
Identities = 188/681 (27%), Positives = 278/681 (40%), Gaps = 164/681 (24%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
CGG ++ G I+SP +P Y C W I E + L+F +F +E +D L
Sbjct: 32 CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED----FDILS 87
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF-FKEEDECAK 580
V DG + L R G+ P I ST + L + F +D V+ GF A + C
Sbjct: 88 VYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGN 147
Query: 581 PD---RGGCEQRCLNTLGSYQCACEPGYEL-GPDRRSC-------------------EAA 617
P +G N + +C PGY L G +C E A
Sbjct: 148 PGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEGA 207
Query: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677
CGG L + +I++P +P EY N +C W ++A I++ F F+LE YD++E
Sbjct: 208 CGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEG----YDFLE 263
Query: 678 IWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKD 737
I SG + S G +P + S N +R+ F SD+ +KGF A F K K
Sbjct: 264 I-SGTEAPSIW---LTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIELKS 319
Query: 738 NG--------GCQHECVNTMG-----SYMC-------------------------QCRNG 759
G G V + G S MC C +
Sbjct: 320 RGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSCEDN 379
Query: 760 FVLH------------------DNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECT 801
+VL D++ C+ C + PSG+ITSPN+P +Y C
Sbjct: 380 YVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCV 439
Query: 802 WEISAT-PGHRIKLAFSEFEIEQHQECAYDHLEVFD----GETEKSPILGRLCGNKIPDP 856
W I+ T P IKLAF EFE+E+ YD L V D G+T +L L G+ +PD
Sbjct: 440 WVITTTDPDKVIKLAFEEFELER----GYDTLTVGDAGKVGDTRS--VLYVLTGSSVPDL 493
Query: 857 LVATGNKMFVRFVSDASVQRKGFQA------------------------------THSTE 886
+V+ N+M++ SD S+ GF+A T + E
Sbjct: 494 IVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTFE 553
Query: 887 CGGRLK---------------AESKPRDLYS-----HAQFG---DNNYPGQ----VDCEW 919
C + + +KP ++S A G NYP + ++C W
Sbjct: 554 CPAAFELVGERVITCQQNNQWSGNKPSCVFSCFFNFTASSGIILSPNYPEEYGNNMNCVW 613
Query: 920 LLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGD 979
L++SE GSR+ L F F+VE + +D++ + D S LG F G+ P ++ S G
Sbjct: 614 LIISEPGSRIHLIFNDFDVEPQ----FDFLAVKDDGISDITVLGTFSGNEVPSQLASSGH 669
Query: 980 SVLIHFHTDDTINKKGFHIRY 1000
V + F +D + +GF+I Y
Sbjct: 670 IVRLEFQSDHSTTGRGFNITY 690
Score = 199 bits (507), Expect = 8e-51
Identities = 139/454 (30%), Positives = 215/454 (47%), Gaps = 56/454 (12%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
C G + G I SP YP+ Y C+WKI V+E + + SF E++ +D LE
Sbjct: 1803 CSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN----WDSLE 1858
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF----FKEEDE 577
+ DG +P +G F G P + STSN L++ F SD +V AGF + E
Sbjct: 1859 IHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQE 1918
Query: 578 CAKPDRGGC--EQRCLNTLGSYQCACEPGYEL----------GPDRR------SCEAACG 619
A P ++ +N + S+QC EPGY L G RR C A CG
Sbjct: 1919 PALPSNSIKIGDRYMVNDVLSFQC--EPGYTLQGRSHISCMPGTVRRWNYPSPLCIATCG 1976
Query: 620 GLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIW 679
G L+ L G I +PG+P YP N +C W++ P Y ++F F E N +D++EI
Sbjct: 1977 GTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN----HDFLEIQ 2032
Query: 680 SGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFK-AHFFSDKDECSK-- 736
+G S + G+F G ++P + S + I F SD++ +++GFK A+ + C
Sbjct: 2033 NGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNCPDPP 2092
Query: 737 --DNGGCQHECVNTMGSYMCQCRNGFVLHDN-----KHDCK----------EAECEQKIH 779
NG + + S +C G++L + +H +A C +
Sbjct: 2093 PFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCGYNVT 2152
Query: 780 SPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGET 839
S +G I SP +PD+YP K+C W I+ PGH + + F+ + E D++ V+DG
Sbjct: 2153 SQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQ----TEAVNDYIAVWDGPD 2208
Query: 840 EKSPILGRLCGNKIPDPLVATGNKMFVRFVSDAS 873
+ SP LG GN + ++ N++ ++F SD S
Sbjct: 2209 QNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFS 2242
Score = 198 bits (503), Expect = 2e-50
Identities = 143/468 (30%), Positives = 216/468 (46%), Gaps = 65/468 (13%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CG ++ NEG + SPN+P +Y EC++KI + L +SF++ D
Sbjct: 1103 AECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEGDT----- 1157
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDI-RSTSNTLWMKFVSDGTVNKAGFAANFFK-EEDE 577
L+V DG +S +G F + I STSN LW++F ++G+ GF + + +
Sbjct: 1158 LKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLVK 1217
Query: 578 CAKPD------RGGCEQRCLNTLGSYQCACEPGYE---------LGPDRR-------SCE 615
C P R E +T+ Y +C PGY L DRR SC
Sbjct: 1218 CEDPGIPNYGYRIRDEGHFTDTVVLY--SCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCI 1275
Query: 616 AACGGLL-TKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
A CGG + +G I +PG+P Y N +C W + A IS+ F F+ E +D
Sbjct: 1276 AECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTE----MAHD 1331
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
+++W G L ++ G+ +PE I S FN++ ++F SD +SK GF F +
Sbjct: 1332 ILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAAT 1391
Query: 735 SKDNG--------GCQHECVNTMGSYMC---------------QCRNGFVLHDNKHDCKE 771
D G G E +T+ ++ C Q N F + C
Sbjct: 1392 CNDPGMPQNGTRYGDSREAGDTV-TFQCDPGYQLQGQAKITCVQLNNRFFWQPDPPTC-I 1449
Query: 772 AECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDH 831
A C + P+G+I SPN+P YP KEC W + P I L F F +E +YD
Sbjct: 1450 AACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEP----SYDF 1505
Query: 832 LEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGF 879
L +++GE SP++G G++ P+ + ++GN +F+ F SDASV GF
Sbjct: 1506 LHIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGF 1553
Score = 197 bits (501), Expect = 4e-50
Identities = 137/461 (29%), Positives = 209/461 (45%), Gaps = 55/461 (11%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHV-GLTFQSFEIERHDNCAYDYL 520
CG +R G I SPNYP Y CVW IT ++ V L F+ FE+ER YD L
Sbjct: 412 CGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELER----GYDTL 467
Query: 521 EVRDG--TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFK-EEDE 577
V D + ++ G P+ I S SN +W+ SD ++ GF A + + E+
Sbjct: 468 TVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGG 527
Query: 578 CAKPDRGGCEQR-----------------CLNTLGSYQCACEPGYELGPDRRSCEAACGG 620
C P +R +G C+ + ++ SC +C
Sbjct: 528 CGDPGIPAYGKRTGSSFLHGDTLTFECPAAFELVGERVITCQQNNQWSGNKPSCVFSCFF 587
Query: 621 LLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWS 680
T +G I +P +P+EY N NCVW +++ RI + F F++E ++D++ +
Sbjct: 588 NFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEP----QFDFLAVKD 643
Query: 681 GLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS-DKDEC----- 734
S+ + G F G EVP + S + +R+EF+SD++ + +GF + + ++EC
Sbjct: 644 DGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGI 703
Query: 735 --------------SKDNGGCQHECVNTMGSYMCQC--RNGFVLHDNKHDCKEAECEQKI 778
S + C V T GS C ++G V+ + EA C +
Sbjct: 704 PINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHL 763
Query: 779 HSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGE 838
+ SG+I P WP Y C W I A PGH IK+ F F+ E + YD LEV DG
Sbjct: 764 TASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTEVN----YDTLEVRDGP 819
Query: 839 TEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGF 879
SP++G G + P L++TGN M++ F +D S GF
Sbjct: 820 ASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRSSIGF 860
Score = 180 bits (457), Expect = 5e-45
Identities = 137/489 (28%), Positives = 215/489 (43%), Gaps = 60/489 (12%)
Query: 441 IEFRSSSNWVGKGFAAVYEAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHV 500
I + ++ W G + V+ C + G I SPNYP++Y CVW I +
Sbjct: 566 ITCQQNNQWSGNKPSCVFS--CFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRI 623
Query: 501 GLTFQSFEIERHDNCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDG 560
L F F++E +D+L V+D + ++G F G + P + S+ + + ++F SD
Sbjct: 624 HLIFNDFDVEPQ----FDFLAVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDH 679
Query: 561 TVNKAGFAANFFK-EEDECAKPD------RGG------------CEQRCLNTLGSYQCAC 601
+ GF + ++EC P R G C+ + T GS C
Sbjct: 680 STTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDGFVKTQGSESITC 739
Query: 602 ---EPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISV 658
+ CEA CGG LT +G I PGWP Y + +C W + A + I +
Sbjct: 740 ILQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKI 799
Query: 659 KFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTV 718
F+ F+ E N YD +E+ G +S S L G++ G + P+ + S N M + F +DN+
Sbjct: 800 TFDRFQTEVN----YDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSR 855
Query: 719 SKKGFKAHFFS---DKDECSKD----NGGCQHECVNTMGSYMCQCRNGFVLHDNK----- 766
S GF H+ S + D C NG + C G+ L D++
Sbjct: 856 SSIGFLIHYESVTLESDSCLDPGIPVNGHRHGGDFGIRSTVTFSCDPGYTLSDDEPLVCE 915
Query: 767 --HDCK------EAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSE 818
H +A C I SG + SP +PD YP+ CTW I + G +++ F
Sbjct: 916 RNHQWNHALPSCDALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHT 975
Query: 819 FEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVA--TGN-KMFVRFVSDASVQ 875
F H E ++D+L + + + P+ RL G+ +P + A GN +RF+SD S+
Sbjct: 976 F----HLESSHDYLLITEDGSFSEPV-ARLTGSVLPHTIKAGLFGNFTAQLRFISDFSIS 1030
Query: 876 RKGFQATHS 884
+GF T S
Sbjct: 1031 YEGFNITFS 1039
Score = 180 bits (456), Expect = 7e-45
Identities = 137/472 (29%), Positives = 213/472 (45%), Gaps = 62/472 (13%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CGG + G I SP +P Y +C W+I++ Y + F +F E + +D+
Sbjct: 1973 ATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN----HDF 2028
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEE-DEC 578
LE+++G SP+IG+F G D P + ST++ + F SD + N+ GF + E C
Sbjct: 2029 LEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYELQNC 2088
Query: 579 AKPD--RGGCEQRCLNTLG-SYQCACEPGYEL----------GPDRR------SCEAACG 619
P + G ++G S C PGY L G +R C+A CG
Sbjct: 2089 PDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCDAPCG 2148
Query: 620 GLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIW 679
+T NGTI +PG+P EYP K+C+W + P + + + F + E DY+ +W
Sbjct: 2149 YNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN----DYIAVW 2204
Query: 680 SGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGF---KAHFFSDKDECSK 736
G S G F G E S N + ++F SD S GF H F K +C
Sbjct: 2205 DGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSD--FSNGGFFVLNFHAFQLK-KCQP 2261
Query: 737 DNGGCQHECVNT-----MGSYM-CQCRNGFVLHDNKH-DCK--------------EAEC- 774
Q E + +G ++ QC G+ L CK EA+C
Sbjct: 2262 PPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEAQCP 2321
Query: 775 -EQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
+ SG+I SP +P Y + + C+W I P + I + F+ E+ +D LE
Sbjct: 2322 ANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQ----FDALE 2377
Query: 834 VFDGETEKSPILGRLCGNKIPDP-LVATGNKMFVRFVSDASVQRKGFQATHS 884
VFDG + +SP+L L GN + N++++R+ +D + +KGF+ ++
Sbjct: 2378 VFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYA 2429
Score = 172 bits (437), Expect = 1e-42
Identities = 166/688 (24%), Positives = 262/688 (38%), Gaps = 168/688 (24%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
E CGG +R I SP++P +Y +C W I + L F F++E YD
Sbjct: 205 EGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEE----GYD 260
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF------- 571
+LE+ GT S + G + P + S+ N L + F SD + GF A F
Sbjct: 261 FLEI-SGTEAPSIWL---TGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIE 316
Query: 572 FKEEDECAKPDRGGCEQRCLNTLG------------------------------SYQCAC 601
K P + G + + + G + Q +C
Sbjct: 317 LKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGANVQFSC 376
Query: 602 EPGYEL------------------GPDRRSCEA-ACGGLLTKLNGTITTPGWPKEYPPNK 642
E Y L R C A CG L +G IT+P +P +Y N
Sbjct: 377 EDNYVLQGSKSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNYPVQYEDNA 436
Query: 643 NCVWQVVAPTQYR-ISVKFEFFELEGNEVCKYDYVEIWSG--LSSESKLHGKFCGAEVPE 699
+CVW + + I + FE FELE YD + + + + G+ VP+
Sbjct: 437 HCVWVITTTDPDKVIKLAFEEFELERG----YDTLTVGDAGKVGDTRSVLYVLTGSSVPD 492
Query: 700 VITSQFNNMRIEFKSDNTVSKKGFKAHFFS-DKDECS--------KDNGGC-------QH 743
+I S N M + +SD+++ GFKA + +K C K G
Sbjct: 493 LIVSMSNQMWLHLQSDDSIGSPGFKAVYQEIEKGGCGDPGIPAYGKRTGSSFLHGDTLTF 552
Query: 744 EC---VNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKEC 800
EC +G + C+ NK C + C + SG+I SPN+P++Y + C
Sbjct: 553 ECPAAFELVGERVITCQQNNQWSGNKPSCVFS-CFFNFTASSGIILSPNYPEEYGNNMNC 611
Query: 801 TWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVAT 860
W I + PG RI L F++F++E +D L V D +LG GN++P L ++
Sbjct: 612 VWLIISEPGSRIHLIFNDFDVEPQ----FDFLAVKDDGISDITVLGTFSGNEVPSQLASS 667
Query: 861 ---------------------------------------GNKMFVRFVSDASVQ---RKG 878
G + RF+ +SV G
Sbjct: 668 GHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPINGRRFGDRFLLGSSVSFHCDDG 727
Query: 879 FQATHSTE-----------------------CGGRLKAESKPRDLYSHAQFGDNNYPGQV 915
F T +E CGG L A S Y +
Sbjct: 728 FVKTQGSESITCILQDGNVVWSSTVPRCEAPCGGHLTASSG----VILPPGWPGYYKDSL 783
Query: 916 DCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIY 975
CEW++ ++ G ++++F F+ E YD +E+ DG S++ +G + G+ P+ +
Sbjct: 784 HCEWIIEAKPGHSIKITFDRFQTE----VNYDTLEVRDGPASSSPLIGEYHGTQAPQFLI 839
Query: 976 SIGDSVLIHFHTDDTINKKGFHIRYKSI 1003
S G+ + + F TD++ + GF I Y+S+
Sbjct: 840 STGNFMYLLFTTDNSRSSIGFLIHYESV 867
Score = 169 bits (428), Expect = 1e-41
Identities = 165/637 (25%), Positives = 255/637 (40%), Gaps = 128/637 (20%)
Query: 460 AICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
A CGG+ +EG + SPNYP +Y + C++ ITV + + V F F+ +D
Sbjct: 1624 APCGGQYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALND-----L 1678
Query: 520 LEVRDGTSENSPLIGRFCGYDKPEDIR-STSNTLWMKFVSDGTVNKAGFAANFFK----E 574
E+ DGT + L+ G E + +TSN + ++F + + GF +
Sbjct: 1679 AELFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAVPRTS 1738
Query: 575 EDECAKPDRGGCEQRCLNTLGSYQCA-------CEPGYELGPDRR--------------- 612
+ +C+ E R +GS A C PGY L
Sbjct: 1739 DTQCSSVP----EPRYGRRIGSEFSAGSIVRFECNPGYLLQGSTALHCQSVPNALAQWND 1794
Query: 613 ---SCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNE 669
SC C G T+ GTI +PG+P+ Y N NC+W+++ I ++ F E N
Sbjct: 1795 TIPSCVVPCSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN- 1853
Query: 670 VCKYDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHF-- 727
+D +EI G + G F G VP ++ S N + + F+SD +V+ GF +
Sbjct: 1854 ---WDSLEIHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKT 1910
Query: 728 --FSDKDECSKDNGGCQ---HECVNTMGSYMCQCRNGFVLHDNKH-DCKE---------- 771
+ E + + + VN + S+ QC G+ L H C
Sbjct: 1911 VGLAACQEPALPSNSIKIGDRYMVNDVLSF--QCEPGYTLQGRSHISCMPGTVRRWNYPS 1968
Query: 772 ----AECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQEC 827
A C + + G+I SP +P YP+ +CTW IS G+ + F F E +
Sbjct: 1969 PLCIATCGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNFSTEAN--- 2025
Query: 828 AYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGF----QATH 883
+D LE+ +G SP++G+ G +P L++T ++ + F SD S R+GF QA
Sbjct: 2026 -HDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQAYE 2084
Query: 884 STEC------------------GGRLKAESKP-RDLYSH----AQFGDN---NYP---GQ 914
C G + E P L H Q G N NYP
Sbjct: 2085 LQNCPDPPPFQNGYMINSDYSVGQSVSFECYPGYILIGHPVLTCQHGINRNWNYPFPRCD 2144
Query: 915 VDCEWLLVSERGSRLELSFQTFEVEEEADCGY-----------------------DYVEL 951
C + + S+ G+ F E DC + DY+ +
Sbjct: 2145 APCGYNVTSQNGTIYSPGFPD-EYPILKDCIWLITVPPGHGVYINFTLLQTEAVNDYIAV 2203
Query: 952 FDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTD 988
+DG D + LG F G+ E YS + VL+ FH+D
Sbjct: 2204 WDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSD 2240
Score = 156 bits (395), Expect = 8e-38
Identities = 134/502 (26%), Positives = 220/502 (43%), Gaps = 65/502 (12%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
+A+CGG I+ G + SP +PD Y C W I VS V + F +F +E ++D
Sbjct: 928 DALCGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLES----SHD 983
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRST---SNTLWMKFVSDGTVNKAGFAANFFKEE 575
YL + + S + P + R G P I++ + T ++F+SD +++ GF F + +
Sbjct: 984 YLLITEDGSFSEP-VARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITFSEYD 1042
Query: 576 DE-CAKPDRGGCEQRCLNTLG---SYQCACEPGYEL---------GPDRR-------SCE 615
E C P +R G S +C GY L G RR C
Sbjct: 1043 LEPCDDPGVPAFSRRIGFHFGVGDSLTFSCFLGYRLEGATKLTCLGGGRRVWSAPLPRCV 1102
Query: 616 AACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFEL-EGNEVCKYD 674
A CG + GT+ +P +P Y N C++++ I ++ F+L EG D
Sbjct: 1103 AECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQLFEG------D 1156
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVI-TSQFNNMRIEFKSDNTVSKKGFKAHFFS-DKD 732
++++ G S S+ G F E+ +I S N++ +EF ++ + + +GF+ + S D
Sbjct: 1157 TLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYTSFDLV 1216
Query: 733 ECSKDNGGCQHECVNTMGSY-----MCQCRNGFVLH-DNKHDCKE--------------A 772
+C + G + + C G+ +H N C A
Sbjct: 1217 KCEDPGIPNYGYRIRDEGHFTDTVVLYSCNPGYAMHGSNTLTCLSGDRRVWDKPLPSCIA 1276
Query: 773 ECEQKIHSP-SGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDH 831
EC +IH+ SG I SP +P Y + CTW I A PG I L F F+ E A+D
Sbjct: 1277 ECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEM----AHDI 1332
Query: 832 LEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRL 891
L+V+DG + +L G+ +P+ + +T N + ++F SD + + GF ST
Sbjct: 1333 LKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATC 1392
Query: 892 KAESKPRDLYSHAQFGDNNYPG 913
P+ + ++GD+ G
Sbjct: 1393 NDPGMPQ---NGTRYGDSREAG 1411
Score = 125 bits (313), Expect = 3e-28
Identities = 111/415 (26%), Positives = 178/415 (42%), Gaps = 58/415 (13%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
+A CG + G I SP +PD+Y +K+C+W ITV + V + F + E D
Sbjct: 2144 DAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTE----AVND 2199
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
Y+ V DG +NSP +G F G E S++N + +KF SD + N F NF + +
Sbjct: 2200 YIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSDFS-NGGFFVLNFHAFQLKK 2258
Query: 579 AKPDRGGCEQRCLNTLGSYQCA------CEPGYEL-GPD---------------RRSCEA 616
+P + L ++ C PGY L G D +CEA
Sbjct: 2259 CQPPPAVPQAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCEA 2318
Query: 617 AC--GGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYD 674
C + T +G I +PG+P Y ++ C W + Y I++ + F+ E ++D
Sbjct: 2319 QCPANEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEK----QFD 2374
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEV-ITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDE 733
+E++ G S +S L G + TS+ N + + + +D+ SKKGFK + +
Sbjct: 2375 ALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAA--PY 2432
Query: 734 CS----KDNGGCQHECVNTMGS---YMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLIT 786
CS NGG + +GS Y C+ V H N A C + +P G+
Sbjct: 2433 CSLTHPLKNGGILNRTAGAVGSKVHYFCKPGYRMVGHSN------ATCRR---NPLGMY- 2482
Query: 787 SPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEK 841
W P + + I +PG+ +F+ E + Y+ E F E+ +
Sbjct: 2483 --QWDSLTPLCQAVSCGIPESPGNG---SFTGNEFTLDSKVVYECHEGFKLESSQ 2532
Score = 79.0 bits (193), Expect = 2e-14
Identities = 74/292 (25%), Positives = 121/292 (41%), Gaps = 69/292 (23%)
Query: 770 KEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAY 829
K C + P+G I SP +P YP+ CTW I +RI+L+F F +E+ +
Sbjct: 28 KGQNCGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED----F 83
Query: 830 DHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH----ST 885
D L V+DG+ ++ + RL G ++P +V+TG+ + + F +D +V +GF+A + S
Sbjct: 84 DILSVYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSH 143
Query: 886 ECGG------------RLKAESKPR-------DLYSHAQFGDNNYPGQVDCEWLLVSE-- 924
CG R K R L HA PG W +
Sbjct: 144 TCGNPGEILKGVLHGTRFNIGDKIRYSCLPGYILEGHAILTCIVSPGN-GASWDFPAPFC 202
Query: 925 ----------RGSRLELSFQTF--EVEEEADC-----------------------GYDYV 949
RG+ +S F E E ADC GYD++
Sbjct: 203 RAEGACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEEGYDFL 262
Query: 950 ELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
E+ G ++ ++ L G P + S + + +HF +D +KGF+ +++
Sbjct: 263 EI-SGTEAPSIWL---TGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQ 310
Score = 77.0 bits (188), Expect = 8e-14
Identities = 44/131 (33%), Positives = 70/131 (53%), Gaps = 5/131 (3%)
Query: 332 LSKGDIAQARKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLN 390
L G++ + + RC A CG L S+G + PG+P Y HC W + PG I +
Sbjct: 741 LQDGNVVWSSTVPRCEAPCGGHLTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKIT 800
Query: 391 FTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWV 450
F D +++ + YD +EVRDG SPL+G + G + P+ L ST + M++ F + ++
Sbjct: 801 F---DRFQTEVN-YDTLEVRDGPASSSPLIGEYHGTQAPQFLISTGNFMYLLFTTDNSRS 856
Query: 451 GKGFAAVYEAI 461
GF YE++
Sbjct: 857 SIGFLIHYESV 867
Score = 75.1 bits (183), Expect = 3e-13
Identities = 45/126 (35%), Positives = 66/126 (52%), Gaps = 10/126 (7%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG +Q NG + SPGFP+GYP+Y +C W + +I L+F T L + +D +
Sbjct: 32 CGGLVQGPNGTIESPGFPHGYPNYANCTWIIITGERNRIQLSFHTFALEED----FDILS 87
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI----CG- 463
V DG ++ L R G +LP + ST S + + F + +GF A+YE + CG
Sbjct: 88 VYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALYEVLPSHTCGN 147
Query: 464 -GEIRK 468
GEI K
Sbjct: 148 PGEILK 153
Score = 75.1 bits (183), Expect = 3e-13
Identities = 39/112 (34%), Positives = 58/112 (51%), Gaps = 4/112 (3%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG TL G + SPGFP YP+ C WR+S+ G + F S+ +D++E
Sbjct: 1975 CGGTLSTLGGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNF----STEANHDFLE 2030
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
+++G + SP++G+F G LP L ST I F S + +GF Y+A
Sbjct: 2031 IQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAYQA 2082
Score = 72.4 bits (176), Expect = 2e-12
Identities = 39/102 (38%), Positives = 56/102 (54%), Gaps = 5/102 (4%)
Query: 345 RCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCW 403
RC A CG + NG + SPGFP+ YP CIW ++V PG + +NFT + +
Sbjct: 2142 RCDAPCGYNVTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN--- 2198
Query: 404 YDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRS 445
DYI V DG + SP LG F G+ E S+ +++ ++F S
Sbjct: 2199 -DYIAVWDGPDQNSPQLGVFSGNTALETAYSSTNQVLLKFHS 2239
Score = 68.9 bits (167), Expect = 2e-11
Identities = 37/112 (33%), Positives = 59/112 (52%), Gaps = 4/112 (3%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
ACG L G + SP +P YP C WRV V P I L F + ++ S YD++
Sbjct: 1451 ACGGNLTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPS----YDFL 1506
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYE 459
+ +G SPL+G + G + PE + S+ + +++ FRS ++ GFA ++
Sbjct: 1507 HIYEGEDSNSPLIGSYQGSQAPERIESSGNSLFLAFRSDASVGLSGFAIEFK 1558
Score = 66.2 bits (160), Expect = 1e-10
Identities = 32/113 (28%), Positives = 58/113 (51%), Gaps = 4/113 (3%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
C + G + SPG+P Y + +CIW++ VT G I + + ++ +D +E
Sbjct: 1803 CSGNFTQRRGTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQN----WDSLE 1858
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI 461
+ DG +P LG F G +P +L ST +++++ F+S + GF Y+ +
Sbjct: 1859 IHDGGDVTAPRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTV 1911
Score = 63.2 bits (152), Expect = 1e-09
Identities = 35/124 (28%), Positives = 61/124 (49%), Gaps = 7/124 (5%)
Query: 341 RKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIV-LNFTTMDLYKS 399
R + R CG L+ +G ++SP +P Y HC+W ++ T +K++ L F +L +
Sbjct: 404 RPICRARTCGSNLRGPSGVITSPNYPVQYEDNAHCVWVITTTDPDKVIKLAFEEFELERG 463
Query: 400 SLCWYDYIEVRDG--YWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAV 457
YD + V D +L G +P+++ S ++MW+ +S + GF AV
Sbjct: 464 ----YDTLTVGDAGKVGDTRSVLYVLTGSSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAV 519
Query: 458 YEAI 461
Y+ I
Sbjct: 520 YQEI 523
Score = 62.4 bits (150), Expect = 2e-09
Identities = 40/131 (30%), Positives = 65/131 (49%), Gaps = 7/131 (5%)
Query: 330 TRLSKGDIAQARKLYRCPA-CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIV 388
T L G + L RC A CG +++ + G L SP FP+ Y + CI+++ G+ I
Sbjct: 1085 TCLGGGRRVWSAPLPRCVAECGASVKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIH 1144
Query: 389 LNFTTMDLYKSSLCWYDYIEVRDGYWRKSPLLGRFC-GDKLPEVLTSTDSRMWIEFRSSS 447
L + L++ D ++V DG S LG F + L +L ST + +W+EF ++
Sbjct: 1145 LRTRSFQLFEG-----DTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNG 1199
Query: 448 NWVGKGFAAVY 458
+ +GF Y
Sbjct: 1200 SDTDQGFQLTY 1210
Score = 61.2 bits (147), Expect = 5e-09
Identities = 32/111 (28%), Positives = 56/111 (50%), Gaps = 4/111 (3%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
+C S+G + SP +P Y + +C+W + PG +I L F D+ +D++
Sbjct: 584 SCFFNFTASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEPQ----FDFL 639
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
V+D +LG F G+++P L S+ + +EF+S + G+GF Y
Sbjct: 640 AVKDDGISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITY 690
Score = 56.2 bits (134), Expect = 1e-07
Identities = 27/93 (29%), Positives = 49/93 (52%), Gaps = 4/93 (4%)
Query: 910 NYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSG 969
+YP +DC W + G + F F E +D++E+ +G T+ +G+F G+
Sbjct: 1994 SYPNNLDCTWRISLPIGYGAHIQFLNFSTE----ANHDFLEIQNGPYHTSPMIGQFSGTD 2049
Query: 970 PPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
P + S LIHF++D + N++GF + Y++
Sbjct: 2050 LPAALLSTTHETLIHFYSDHSQNRQGFKLAYQA 2082
Score = 55.8 bits (133), Expect = 2e-07
Identities = 33/121 (27%), Positives = 56/121 (46%), Gaps = 8/121 (6%)
Query: 881 ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEE 940
A CGG ++ P F + YP +C W++++ +R++LSF TF +EE
Sbjct: 26 AAKGQNCGGLVQG---PNGTIESPGF-PHGYPNYANCTWIIITGERNRIQLSFHTFALEE 81
Query: 941 EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
+ +D + ++DG R G P I S G + + F TD ++ +GF Y
Sbjct: 82 D----FDILSVYDGQPQQGNLKVRLSGFQLPSSIVSTGSILTLWFTTDFAVSAQGFKALY 137
Query: 1001 K 1001
+
Sbjct: 138 E 138
Score = 55.5 bits (132), Expect = 3e-07
Identities = 34/114 (29%), Positives = 55/114 (48%), Gaps = 9/114 (7%)
Query: 347 PAC-----GETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSL 401
P+C G+ ++G + SPG+P Y + HC W + PG+ I L+F D +
Sbjct: 1272 PSCIAECGGQIHAATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMA-- 1329
Query: 402 CWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFA 455
+D ++V DG LL + G LPE + ST + + ++F S GF+
Sbjct: 1330 --HDILKVWDGPVDSDILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFS 1381
Score = 50.1 bits (118), Expect = 1e-05
Identities = 35/117 (29%), Positives = 54/117 (46%), Gaps = 6/117 (5%)
Query: 345 RCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWY 404
+CPA E S+G + SPG+P Y + C W + V P I + T K +
Sbjct: 2319 QCPA-NEVRTGSSGVILSPGYPGNYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQ----F 2373
Query: 405 DYIEVRDGYWRKSPLLGRFCGDKLPEV-LTSTDSRMWIEFRSSSNWVGKGFAAVYEA 460
D +EV DG +SPLL G+ + TS +++++ + + KGF Y A
Sbjct: 2374 DALEVFDGSSGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAA 2430
Score = 49.3 bits (116), Expect = 2e-05
Identities = 28/85 (32%), Positives = 45/85 (52%), Gaps = 7/85 (8%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG +Q +G + SPGFP+ YP+ +C W + V+ G+ + + F T L S +DY+
Sbjct: 931 CGGYIQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESS----HDYLL 986
Query: 409 V-RDGYWRKSPLLGRFCGDKLPEVL 432
+ DG + S + R G LP +
Sbjct: 987 ITEDGSF--SEPVARLTGSVLPHTI 1009
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 6/114 (5%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG S G + SP +P+ Y + C++ ++V P E +V F ++++L D E
Sbjct: 1626 CGGQYTGSEGVVLSPNYPHNYTAGQICLYSITV-PKEFVV--FGQFAYFQTAL--NDLAE 1680
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVL-TSTDSRMWIEFRSSSNWVGKGFAAVYEAI 461
+ DG ++ LL G E L +T +++ + F + S +GF VY+A+
Sbjct: 1681 LFDGTHAQARLLSSLSGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQAV 1734
Score = 41.6 bits (96), Expect = 0.004
Identities = 29/105 (27%), Positives = 48/105 (45%), Gaps = 6/105 (5%)
Query: 910 NYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSG 969
NY C W + E + + TF+ E++ +D +E+FDG + L G+
Sbjct: 2341 NYFNSQTCSWSIKVEPNYNITIFVDTFQSEKQ----FDALEVFDGSSGQSPLLVVLSGNH 2396
Query: 970 PPEEIY-SIGDSVLIHFHTDDTINKKGFHIRYKSIRYPDTTHTKK 1013
+ + S + + + + TD +KKGF IRY + Y TH K
Sbjct: 2397 TEQSNFTSRSNQLYLRWSTDHATSKKGFKIRY-AAPYCSLTHPLK 2440
Score = 35.4 bits (80), Expect = 0.27
Identities = 29/117 (24%), Positives = 55/117 (47%), Gaps = 12/117 (10%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG ++ +S F YP ++C W + G +++ F TF +E +
Sbjct: 931 CGGYIQGKSGTVLSPGFPDF----YPNSLNCTWTIEVSHGKGVQMIFHTFHLES----SH 982
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYS--IGD-SVLIHFHTDDTINKKGFHIRY 1000
DY+ + + S + + R GS P I + G+ + + F +D +I+ +GF+I +
Sbjct: 983 DYLLITED-GSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNITF 1038
>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
Length = 449
Score = 169 bits (429), Expect = 9e-42
Identities = 92/269 (34%), Positives = 139/269 (51%), Gaps = 36/269 (13%)
Query: 461 ICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYL 520
+CGG+++ G + S +P+ Y P KEC+W ITV E V L+F+ F++E H C YD L
Sbjct: 36 LCGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDAL 95
Query: 521 EVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK 580
EV G+ + +GRFCG +P + + N + ++ +D GF
Sbjct: 96 EVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGF------------- 142
Query: 581 PDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPK-EYP 639
L Y G E CGG L K GT+TTP WP+ +YP
Sbjct: 143 -------------LLWYSGRATSGTE--------HQFCGGRLEKAQGTLTTPNWPESDYP 181
Query: 640 PNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSG-LSSESKLHGKFCGAEVP 698
P +C W ++AP I++ FE F+LE + C+YD V +++G +S +S+ GKFCG VP
Sbjct: 182 PGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVP 241
Query: 699 EVITSQFNNMRIEFKSDNTVSKKGFKAHF 727
I+S+ N + ++F SD +V+ GF A +
Sbjct: 242 GSISSEGNELLVQFVSDLSVTADGFSASY 270
Score = 155 bits (391), Expect = 2e-37
Identities = 82/282 (29%), Positives = 134/282 (47%), Gaps = 36/282 (12%)
Query: 618 CGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVE 677
CGG + +G + + G+P YPPNK C+W + P +S+ F F+LE + C+YD +E
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
Query: 678 IWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKD 737
+++G + + G+FCG P + + N + + +D +GF + +
Sbjct: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWY------SGRA 150
Query: 738 NGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDK-YPS 796
G +H+ C ++ G +T+PNWP+ YP
Sbjct: 151 TSGTEHQF----------------------------CGGRLEKAQGTLTTPNWPESDYPP 182
Query: 797 RKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGE-TEKSPILGRLCGNKIPD 855
C+W I A P I L F +F++E C YD + VF+G ++ S LG+ CG+ +P
Sbjct: 183 GISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPG 242
Query: 856 PLVATGNKMFVRFVSDASVQRKGFQATHSTECGGRLKAESKP 897
+ + GN++ V+FVSD SV GF A++ T G K P
Sbjct: 243 SISSEGNELLVQFVSDLSVTADGFSASYKTLPRGTAKEGQGP 284
Score = 154 bits (390), Expect = 3e-37
Identities = 82/240 (34%), Positives = 127/240 (52%), Gaps = 13/240 (5%)
Query: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
C + SG + S +P+ YP KEC W I+ G + L+F F++E H C YD LE
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
Query: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGF------QATHSTE- 886
VF G LGR CG P PLVA GN++ +R +D +GF +AT TE
Sbjct: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
Query: 887 --CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADC 944
CGGRL+ K + + + +++YP + C W +++ + L+F+ F++E + C
Sbjct: 157 QFCGGRLE---KAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYC 213
Query: 945 GYDYVELFDG-LDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSI 1003
YD V +F+G + + LG+FCG P I S G+ +L+ F +D ++ GF YK++
Sbjct: 214 RYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTL 273
Score = 147 bits (370), Expect = 6e-35
Identities = 83/247 (33%), Positives = 124/247 (50%), Gaps = 11/247 (4%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG ++ +G ++S GFPN YP CIW ++V G+ + L+F DL C YD +E
Sbjct: 37 CGGDVKGESGYVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRYDALE 96
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA-------- 460
V G LGRFCG P L + +++ + + G+GF Y
Sbjct: 97 VFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATSGTEH 156
Query: 461 -ICGGEIRKNEGQIQSPNYPD-DYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
CGG + K +G + +PN+P+ DY P C W I + LTF+ F++E C YD
Sbjct: 157 QFCGGRLEKAQGTLTTPNWPESDYPPGISCSWHIIAPPDQVIALTFEKFDLEPDTYCRYD 216
Query: 519 YLEVRDG-TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDE 577
+ V +G S++S +G+FCG P I S N L ++FVSD +V GF+A++
Sbjct: 217 SVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLSVTADGFSASYKTLPRG 276
Query: 578 CAKPDRG 584
AK +G
Sbjct: 277 TAKEGQG 283
Score = 73.9 bits (180), Expect = 7e-13
Identities = 40/124 (32%), Positives = 61/124 (49%), Gaps = 4/124 (3%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG +K ES Y ++ N YP +C W + G + LSF+ F++E C Y
Sbjct: 37 CGGDVKGESG----YVASEGFPNLYPPNKECIWTITVPEGQTVSLSFRVFDLELHPACRY 92
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYP 1006
D +E+F G ++ LGRFCG+ P + + G+ V + TD+ +GF + Y
Sbjct: 93 DALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVTLRMTTDEGTGGRGFLLWYSGRATS 152
Query: 1007 DTTH 1010
T H
Sbjct: 153 GTEH 156
>gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [Homo
sapiens]
Length = 380
Score = 167 bits (424), Expect = 4e-41
Identities = 92/280 (32%), Positives = 149/280 (53%), Gaps = 27/280 (9%)
Query: 622 LTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSG 681
L + G I +PG+P YP + W + P +RI + F F LE + +C+YDYV++
Sbjct: 24 LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV--- 80
Query: 682 LSSESKLHGKFCGAEVP--------EVITSQFNNMRIEFKSDNTVSKK--GFKAHFFS-D 730
+E ++ FCG E EV+ S + M I F+SD + ++ GF AH+ + D
Sbjct: 81 -ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
Query: 731 KDECSK---DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSP-SGLIT 786
DEC + + C H C N +G Y C CR G++LH + C+ EC + + +G+IT
Sbjct: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCR-VECSDNLFTQRTGVIT 198
Query: 787 SPNWPDKYPSRKECTWEISATPGHRIKLAFSE-FEIEQHQE--CAYDHLEVFDGETEKSP 843
SP++P+ YP EC + I G + L F + F+IE H E C YD++++ G
Sbjct: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
Query: 844 ILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
+LG CG K P+P+ + + + F SD S + +G++ ++
Sbjct: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
Score = 153 bits (387), Expect = 7e-37
Identities = 106/360 (29%), Positives = 173/360 (48%), Gaps = 43/360 (11%)
Query: 465 EIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRD 524
E+ GQIQSP YPD Y E W ITV + + + L F F +E C YDY++V
Sbjct: 23 ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
Query: 525 GTSENSPLIGRFCGYDK--------PEDIRSTSNTLWMKFVSDGTVNK--AGFAANFFK- 573
++ FCG + E + S + + + F SD + + GF A++
Sbjct: 81 --ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
Query: 574 EEDEC--AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACG-GLLTKLNGTIT 630
+ DEC + + C+ C N +G Y C+C GY L D R+C C L T+ G IT
Sbjct: 139 DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
Query: 631 TPGWPKEYPPNKNCVWQVVAPTQYRISVKFE-FFELEGN-EV-CKYDYVEIWSGLSSESK 687
+P +P YP + C++ + + ++++FE F++E + EV C YDY++I G K
Sbjct: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
Query: 688 LHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVN 747
+ G FCG + PE I++Q +++ I F SDN+ +G++ + + +EC + +
Sbjct: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEP 314
Query: 748 TMGSY------MCQCRNGF-VLHDN-KHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKE 799
+ Y + C G+ VL DN + D + EC + W +K P+ K+
Sbjct: 315 SQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIEC----------LKDGTWSNKIPTCKK 364
Score = 104 bits (260), Expect = 4e-22
Identities = 91/330 (27%), Positives = 143/330 (43%), Gaps = 75/330 (22%)
Query: 348 ACGETLQESN--GNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405
A T++ +N G + SPG+P+ YPS + W ++V G +I L F +L S LC YD
Sbjct: 17 ASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYD 76
Query: 406 YIEVRDGYWRKSPLLGRFCG------DKLP--EVLTSTDSRMWIEFRS--SSNWVGKGFA 455
Y++V + +L FCG ++ P EV+ S S M I FRS S+ GF
Sbjct: 77 YVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFD 132
Query: 456 AVYEAICGGEIRKNE--------------------------------------------- 470
A Y A+ E ++ E
Sbjct: 133 AHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQ 192
Query: 471 --GQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS-FEIERHDN--CAYDYLEVRDG 525
G I SP++P+ Y EC++ I + E + V L F+ F+IE H C YDY++++ G
Sbjct: 193 RTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG 252
Query: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK---PD 582
++G FCG PE I + S+++ + F SD + G+ ++ +EC + P
Sbjct: 253 PK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPV 308
Query: 583 RGGCEQRCLNTLGSYQ--CACEPGYELGPD 610
G E Q +C+ GY++ D
Sbjct: 309 HGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
Score = 101 bits (251), Expect = 4e-21
Identities = 82/283 (28%), Positives = 123/283 (43%), Gaps = 66/283 (23%)
Query: 777 KIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFD 836
++++ G I SP +PD YPS E TW I+ G RIKL F F +E C YD+++V
Sbjct: 23 ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
Query: 837 GETEKSPILGRLCGNKIPDP--------LVATGNKMFVRFVSDASVQRK--GFQATHST- 885
ETE +L CG + D +++ G+ M + F SD S + + GF A +
Sbjct: 81 -ETE-DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
Query: 886 ---ECGGRLKAESKPRDLYSHAQFG----------------------------------- 907
EC R + E D Y H G
Sbjct: 139 DVDECKER-EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVI 197
Query: 908 -----DNNYPGQVDCEWLLVSERGSRLELSFQ-TFEVEE--EADCGYDYVELFDGLDSTA 959
N YP +C + + E G + L F+ F++E+ E C YDY+++ G
Sbjct: 198 TSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----P 253
Query: 960 VGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
LG FCG PE I + SVLI FH+D++ +G+ + Y++
Sbjct: 254 KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA 296
>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
precursor [Homo sapiens]
Length = 728
Score = 167 bits (424), Expect = 4e-41
Identities = 92/280 (32%), Positives = 149/280 (53%), Gaps = 27/280 (9%)
Query: 622 LTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSG 681
L + G I +PG+P YP + W + P +RI + F F LE + +C+YDYV++
Sbjct: 24 LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV--- 80
Query: 682 LSSESKLHGKFCGAEVP--------EVITSQFNNMRIEFKSDNTVSKK--GFKAHFFS-D 730
+E ++ FCG E EV+ S + M I F+SD + ++ GF AH+ + D
Sbjct: 81 -ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
Query: 731 KDECSK---DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSP-SGLIT 786
DEC + + C H C N +G Y C CR G++LH + C+ EC + + +G+IT
Sbjct: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCR-VECSDNLFTQRTGVIT 198
Query: 787 SPNWPDKYPSRKECTWEISATPGHRIKLAFSE-FEIEQHQE--CAYDHLEVFDGETEKSP 843
SP++P+ YP EC + I G + L F + F+IE H E C YD++++ G
Sbjct: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
Query: 844 ILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
+LG CG K P+P+ + + + F SD S + +G++ ++
Sbjct: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
Score = 153 bits (386), Expect = 9e-37
Identities = 106/359 (29%), Positives = 172/359 (47%), Gaps = 43/359 (11%)
Query: 465 EIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRD 524
E+ GQIQSP YPD Y E W ITV + + + L F F +E C YDY++V
Sbjct: 23 ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
Query: 525 GTSENSPLIGRFCGYDK--------PEDIRSTSNTLWMKFVSDGTVNK--AGFAANFFK- 573
++ FCG + E + S + + + F SD + + GF A++
Sbjct: 81 --ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
Query: 574 EEDEC--AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACG-GLLTKLNGTIT 630
+ DEC + + C+ C N +G Y C+C GY L D R+C C L T+ G IT
Sbjct: 139 DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
Query: 631 TPGWPKEYPPNKNCVWQVVAPTQYRISVKFE-FFELEGN-EV-CKYDYVEIWSGLSSESK 687
+P +P YP + C++ + + ++++FE F++E + EV C YDY++I G K
Sbjct: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
Query: 688 LHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVN 747
+ G FCG + PE I++Q +++ I F SDN+ +G++ + + +EC + +
Sbjct: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEP 314
Query: 748 TMGSY------MCQCRNGF-VLHDN-KHDCKEAECEQKIHSPSGLITSPNWPDKYPSRK 798
+ Y + C G+ VL DN + D + EC + W +K P+ K
Sbjct: 315 SQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIEC----------LKDGTWSNKIPTCK 363
Score = 104 bits (260), Expect = 4e-22
Identities = 91/330 (27%), Positives = 143/330 (43%), Gaps = 75/330 (22%)
Query: 348 ACGETLQESN--GNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405
A T++ +N G + SPG+P+ YPS + W ++V G +I L F +L S LC YD
Sbjct: 17 ASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYD 76
Query: 406 YIEVRDGYWRKSPLLGRFCG------DKLP--EVLTSTDSRMWIEFRS--SSNWVGKGFA 455
Y++V + +L FCG ++ P EV+ S S M I FRS S+ GF
Sbjct: 77 YVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFD 132
Query: 456 AVYEAICGGEIRKNE--------------------------------------------- 470
A Y A+ E ++ E
Sbjct: 133 AHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQ 192
Query: 471 --GQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS-FEIERHDN--CAYDYLEVRDG 525
G I SP++P+ Y EC++ I + E + V L F+ F+IE H C YDY++++ G
Sbjct: 193 RTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG 252
Query: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK---PD 582
++G FCG PE I + S+++ + F SD + G+ ++ +EC + P
Sbjct: 253 PK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPV 308
Query: 583 RGGCEQRCLNTLGSYQ--CACEPGYELGPD 610
G E Q +C+ GY++ D
Sbjct: 309 HGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
Score = 101 bits (251), Expect = 4e-21
Identities = 82/283 (28%), Positives = 123/283 (43%), Gaps = 66/283 (23%)
Query: 777 KIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFD 836
++++ G I SP +PD YPS E TW I+ G RIKL F F +E C YD+++V
Sbjct: 23 ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
Query: 837 GETEKSPILGRLCGNKIPDP--------LVATGNKMFVRFVSDASVQRK--GFQATHST- 885
ETE +L CG + D +++ G+ M + F SD S + + GF A +
Sbjct: 81 -ETE-DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
Query: 886 ---ECGGRLKAESKPRDLYSHAQFG----------------------------------- 907
EC R + E D Y H G
Sbjct: 139 DVDECKER-EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVI 197
Query: 908 -----DNNYPGQVDCEWLLVSERGSRLELSFQ-TFEVEE--EADCGYDYVELFDGLDSTA 959
N YP +C + + E G + L F+ F++E+ E C YDY+++ G
Sbjct: 198 TSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----P 253
Query: 960 VGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
LG FCG PE I + SVLI FH+D++ +G+ + Y++
Sbjct: 254 KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA 296
>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
precursor [Homo sapiens]
Length = 699
Score = 167 bits (424), Expect = 4e-41
Identities = 92/280 (32%), Positives = 149/280 (53%), Gaps = 27/280 (9%)
Query: 622 LTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSG 681
L + G I +PG+P YP + W + P +RI + F F LE + +C+YDYV++
Sbjct: 24 LNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV--- 80
Query: 682 LSSESKLHGKFCGAEVP--------EVITSQFNNMRIEFKSDNTVSKK--GFKAHFFS-D 730
+E ++ FCG E EV+ S + M I F+SD + ++ GF AH+ + D
Sbjct: 81 -ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAVD 139
Query: 731 KDECSK---DNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSP-SGLIT 786
DEC + + C H C N +G Y C CR G++LH + C+ EC + + +G+IT
Sbjct: 140 VDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCR-VECSDNLFTQRTGVIT 198
Query: 787 SPNWPDKYPSRKECTWEISATPGHRIKLAFSE-FEIEQHQE--CAYDHLEVFDGETEKSP 843
SP++P+ YP EC + I G + L F + F+IE H E C YD++++ G
Sbjct: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
Query: 844 ILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
+LG CG K P+P+ + + + F SD S + +G++ ++
Sbjct: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSY 294
Score = 153 bits (386), Expect = 9e-37
Identities = 106/359 (29%), Positives = 172/359 (47%), Gaps = 43/359 (11%)
Query: 465 EIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRD 524
E+ GQIQSP YPD Y E W ITV + + + L F F +E C YDY++V
Sbjct: 23 ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
Query: 525 GTSENSPLIGRFCGYDK--------PEDIRSTSNTLWMKFVSDGTVNK--AGFAANFFK- 573
++ FCG + E + S + + + F SD + + GF A++
Sbjct: 81 --ETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
Query: 574 EEDEC--AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACG-GLLTKLNGTIT 630
+ DEC + + C+ C N +G Y C+C GY L D R+C C L T+ G IT
Sbjct: 139 DVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVIT 198
Query: 631 TPGWPKEYPPNKNCVWQVVAPTQYRISVKFE-FFELEGN-EV-CKYDYVEIWSGLSSESK 687
+P +P YP + C++ + + ++++FE F++E + EV C YDY++I G K
Sbjct: 199 SPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----PK 254
Query: 688 LHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDECSKDNGGCQHECVN 747
+ G FCG + PE I++Q +++ I F SDN+ +G++ + + +EC + +
Sbjct: 255 VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPVHGKIEP 314
Query: 748 TMGSY------MCQCRNGF-VLHDN-KHDCKEAECEQKIHSPSGLITSPNWPDKYPSRK 798
+ Y + C G+ VL DN + D + EC + W +K P+ K
Sbjct: 315 SQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIEC----------LKDGTWSNKIPTCK 363
Score = 104 bits (260), Expect = 4e-22
Identities = 91/330 (27%), Positives = 143/330 (43%), Gaps = 75/330 (22%)
Query: 348 ACGETLQESN--GNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYD 405
A T++ +N G + SPG+P+ YPS + W ++V G +I L F +L S LC YD
Sbjct: 17 ASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYD 76
Query: 406 YIEVRDGYWRKSPLLGRFCG------DKLP--EVLTSTDSRMWIEFRS--SSNWVGKGFA 455
Y++V + +L FCG ++ P EV+ S S M I FRS S+ GF
Sbjct: 77 YVKVE----TEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFD 132
Query: 456 AVYEAICGGEIRKNE--------------------------------------------- 470
A Y A+ E ++ E
Sbjct: 133 AHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQ 192
Query: 471 --GQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQS-FEIERHDN--CAYDYLEVRDG 525
G I SP++P+ Y EC++ I + E + V L F+ F+IE H C YDY++++ G
Sbjct: 193 RTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG 252
Query: 526 TSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAK---PD 582
++G FCG PE I + S+++ + F SD + G+ ++ +EC + P
Sbjct: 253 PK----VLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNECPELQPPV 308
Query: 583 RGGCEQRCLNTLGSYQ--CACEPGYELGPD 610
G E Q +C+ GY++ D
Sbjct: 309 HGKIEPSQAKYFFKDQVLVSCDTGYKVLKD 338
Score = 101 bits (251), Expect = 4e-21
Identities = 82/283 (28%), Positives = 123/283 (43%), Gaps = 66/283 (23%)
Query: 777 KIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFD 836
++++ G I SP +PD YPS E TW I+ G RIKL F F +E C YD+++V
Sbjct: 23 ELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKLYFMHFNLESSYLCEYDYVKV-- 80
Query: 837 GETEKSPILGRLCGNKIPDP--------LVATGNKMFVRFVSDASVQRK--GFQATHST- 885
ETE +L CG + D +++ G+ M + F SD S + + GF A +
Sbjct: 81 -ETE-DQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRSDFSNEERFTGFDAHYMAV 138
Query: 886 ---ECGGRLKAESKPRDLYSHAQFG----------------------------------- 907
EC R + E D Y H G
Sbjct: 139 DVDECKER-EDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSDNLFTQRTGVI 197
Query: 908 -----DNNYPGQVDCEWLLVSERGSRLELSFQ-TFEVEE--EADCGYDYVELFDGLDSTA 959
N YP +C + + E G + L F+ F++E+ E C YDY+++ G
Sbjct: 198 TSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEVPCPYDYIKIKVG----P 253
Query: 960 VGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
LG FCG PE I + SVLI FH+D++ +G+ + Y++
Sbjct: 254 KVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRA 296
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 160 bits (406), Expect = 4e-39
Identities = 99/297 (33%), Positives = 146/297 (49%), Gaps = 21/297 (7%)
Query: 459 EAICGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
++ CGG + G SPNYPD Y P CVW I V+ + + L ++ IE +C +D
Sbjct: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
LE+ PL+ R CG P + + ++ L + FVSD +V GF A + +
Sbjct: 201 RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY-----QA 252
Query: 579 AKPDRGGC---EQRC---LNTLGSYQCACEPGYELGPDRRSCEA---ACGGLLTKLNGTI 629
P RG C E RC + L C G D +C A CGG LT L GT
Sbjct: 253 MAPGRGSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTF 312
Query: 630 TTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSES-KL 688
+TP + ++YP C W + P + I ++F F LE + CK+DYVE++ SS + L
Sbjct: 313 STPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSL 372
Query: 689 HGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKA---HFFSDKDECSKDNGGCQ 742
G+FCGAE P + S + + + F++D+ +S GF A F + ++ C CQ
Sbjct: 373 LGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQ 429
Score = 138 bits (347), Expect = 3e-32
Identities = 81/278 (29%), Positives = 141/278 (50%), Gaps = 12/278 (4%)
Query: 613 SCEAACGGLLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCK 672
S ++ CGGLL+ G ++P +P YPPN +CVW + T + I +K E +E C
Sbjct: 139 SPQSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCL 198
Query: 673 YDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS--- 729
+D +E+ E L + CG P + + +++ + F SD++V GF A + +
Sbjct: 199 FDRLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAP 255
Query: 730 DKDECSKDNGGC-QHECV--NTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLIT 786
+ C+ D C Q C+ +++ C +G + K + C + G +
Sbjct: 256 GRGSCAHDEFRCDQLICLLPDSVCDGFANCADG--SDETNCSAKFSGCGGNLTGLQGTFS 313
Query: 787 SPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKS-PIL 845
+P++ +YP + CTW IS GH I+L F F +E EC +D++EV++ + + +L
Sbjct: 314 TPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLL 373
Query: 846 GRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
GR CG + P LV++ +++ V F +D + GF AT+
Sbjct: 374 GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
Score = 120 bits (300), Expect = 8e-27
Identities = 80/294 (27%), Positives = 124/294 (42%), Gaps = 58/294 (19%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L G SSP +P+ YP THC+W + V I L + + + C +D +E
Sbjct: 144 CGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLE 203
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI------- 461
+ + PLL R CG P L + S + + F S S+ G GF A Y+A+
Sbjct: 204 LSPE--PEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRGSC 260
Query: 462 ----------------------------------------CGGEIRKNEGQIQSPNYPDD 481
CGG + +G +P+Y
Sbjct: 261 AHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQ 320
Query: 482 YRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENS-PLIGRFCGYD 540
Y C W I+V + + L F +F +E D C +DY+EV + +S + L+GRFCG +
Sbjct: 321 YPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCGAE 380
Query: 541 KPEDIRSTSNTLWMKFVSDGTVNKAGFAAN---FFKEEDECAKPD----RGGCE 587
P + S+ + L + F +D ++ GF+A F E+ C + GGC+
Sbjct: 381 PPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAGGCK 434
Score = 119 bits (298), Expect = 1e-26
Identities = 79/278 (28%), Positives = 112/278 (40%), Gaps = 55/278 (19%)
Query: 771 EAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYD 830
++ C + P G +SPN+PD YP C W I H I+L IE C +D
Sbjct: 141 QSTCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFD 200
Query: 831 HLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHS------ 884
LE+ + P+L R+CG P L + + V FVSD+SV+ GF A +
Sbjct: 201 RLEL--SPEPEGPLL-RVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGR 257
Query: 885 -----------------------------------------TECGGRLKAESKPRDLYSH 903
+ CGG L S+
Sbjct: 258 GSCAHDEFRCDQLICLLPDSVCDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSY 317
Query: 904 AQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVG-L 962
Q YP Q+ C W + G +EL F F +E + +C +DYVE+++ S A L
Sbjct: 318 LQ----QYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLL 373
Query: 963 GRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
GRFCG+ PP + S + + F TD I+ GF Y
Sbjct: 374 GRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATY 411
Score = 55.5 bits (132), Expect = 3e-07
Identities = 34/129 (26%), Positives = 57/129 (44%), Gaps = 7/129 (5%)
Query: 875 QRKGFQATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQ 934
Q G + + CGG L S PR +S + D YP C W + ++L +
Sbjct: 132 QESGVSPSPQSTCGGLL---SGPRGFFSSPNYPDP-YPPNTHCVWHIQVATDHAIQLKIE 187
Query: 935 TFEVEEEADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKK 994
+E A C +D +EL + + R CG PP + + +L+ F +D ++
Sbjct: 188 ALSIESVASCLFDRLELSPEPEGPLL---RVCGRVPPPTLNTNASHLLVVFVSDSSVEGF 244
Query: 995 GFHIRYKSI 1003
GFH Y+++
Sbjct: 245 GFHAWYQAM 253
>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
Length = 415
Score = 158 bits (399), Expect = 3e-38
Identities = 89/268 (33%), Positives = 137/268 (51%), Gaps = 37/268 (13%)
Query: 462 CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLE 521
CGG + G I S +P Y P +C WKITV E V L F+ ++E + C YD+++
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 522 VRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
V +G + N IGRFCG +P + S+ N + ++ +SD GF A F A+P
Sbjct: 93 VYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMF-----SAAEP 146
Query: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWP-KEYPP 640
+ G + CGGLL + +G+ TP WP ++YP
Sbjct: 147 NERG-----------------------------DQYCGGLLDRPSGSFKTPNWPDRDYPA 177
Query: 641 NKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLS-SESKLHGKFCGAEVPE 699
CVW +VAP I +KFE F++E + C+YDYV +++G ++++ GK+CG P
Sbjct: 178 GVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNDARRIGKYCGDSPPA 237
Query: 700 VITSQFNNMRIEFKSDNTVSKKGFKAHF 727
I S+ N + I+F SD +++ GF H+
Sbjct: 238 PIVSERNELLIQFLSDLSLTADGFIGHY 265
Score = 157 bits (398), Expect = 4e-38
Identities = 82/234 (35%), Positives = 130/234 (55%), Gaps = 12/234 (5%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L +G + S GFP YP + C W+++V G+ +VLNF +DL +LC YD+++
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEA-------- 460
V +G+ +GRFCG P L S+ ++M ++ S +N G GF A++ A
Sbjct: 93 VYNGH-ANGQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
Query: 461 -ICGGEIRKNEGQIQSPNYPD-DYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYD 518
CGG + + G ++PN+PD DY CVW I ++ + L F+ F++ER + C YD
Sbjct: 152 QYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYD 211
Query: 519 YLEVRDGTSEN-SPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571
Y+ V +G N + IG++CG P I S N L ++F+SD ++ GF ++
Sbjct: 212 YVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
Score = 147 bits (372), Expect = 4e-35
Identities = 84/248 (33%), Positives = 127/248 (51%), Gaps = 16/248 (6%)
Query: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
C + SG I S +P YP +CTW+I+ G + L F ++E C YD ++
Sbjct: 33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVD 92
Query: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTE------- 886
V++G I GR CG P LV++GNKM V+ +SDA+ GF A S
Sbjct: 93 VYNGHANGQRI-GRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAEPNERGD 151
Query: 887 --CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADC 944
CGG L +P + + D +YP V C W +V+ + +EL F+ F+VE + C
Sbjct: 152 QYCGGLL---DRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYC 208
Query: 945 GYDYVELFDGLD-STAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGF--HIRYK 1001
YDYV +F+G + + A +G++CG PP I S + +LI F +D ++ GF H ++
Sbjct: 209 RYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIFR 268
Query: 1002 SIRYPDTT 1009
+ P TT
Sbjct: 269 PKKLPTTT 276
>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
Length = 909
Score = 152 bits (385), Expect = 1e-36
Identities = 90/276 (32%), Positives = 136/276 (49%), Gaps = 47/276 (17%)
Query: 462 CGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSE-SYHVGLTFQS-FEIERHDNCAYD 518
CGG + K+ G I SP YP DY + C W + E + + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
++E+RDG SE++ L+G+ CG P I S+ + L++KF SD AGF+ + E
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY-----EI 141
Query: 579 AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEY 638
K C + T NGTI +PG+P++Y
Sbjct: 142 FKTGSEDCSKN--------------------------------FTSPNGTIESPGFPEKY 169
Query: 639 PPNKNCVWQVVAPTQYRISVKFEFFELE------GNEVCKYDYVEIWSGLSSESKLHGKF 692
P N +C + ++A + I ++F F+LE G CKYD+++IW G+ L GK+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 693 CGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFF 728
CG + P + S + + F +D V+K GF A ++
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 150 bits (379), Expect = 6e-36
Identities = 85/246 (34%), Positives = 128/246 (52%), Gaps = 16/246 (6%)
Query: 347 PACGETLQESN-GNLSSPGFPNGYPSYTHCIWRV-SVTPGEKIVLNFTTMDLYKSSLCWY 404
P CG L + G ++SPG+P YPS+ +C W V + P +KIVLNF + C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 405 DYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI--- 461
D+IE+RDG + LLG+ CG+ P + S+ S ++I+F S G GF+ YE
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 462 ---CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD----- 513
C G I+SP +P+ Y +C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 514 --NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571
+C YD+L++ DG PLIG++CG P ++RS++ L + F +D V K GF+A +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 572 FKEEDE 577
+ E
Sbjct: 265 YLVHQE 270
Score = 142 bits (357), Expect = 2e-33
Identities = 81/257 (31%), Positives = 140/257 (54%), Gaps = 23/257 (8%)
Query: 762 LHDNKHDCK---EAECEQKIHSP-SGLITSPNWPDKYPSRKECTWEISAT-PGHRIKLAF 816
L+ ++H + + C +++S +G ITSP +P YPS + C W + A P +I L F
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNF 72
Query: 817 S-EFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQ 875
+ FEIE+H +C YD +E+ DG++E + +LG+ CGN P ++++G+ ++++F SD + Q
Sbjct: 73 NPHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQ 131
Query: 876 RKGFQ------ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRL 929
GF T S +C K + P F + YP +DC + ++++ +
Sbjct: 132 GAGFSLRYEIFKTGSEDCS---KNFTSPNGTIESPGFPE-KYPHNLDCTFTILAKPKMEI 187
Query: 930 ELSFQTFEVEE------EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
L F F++E E DC YD+++++DG+ +G++CG+ P E+ S + +
Sbjct: 188 ILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSL 247
Query: 984 HFHTDDTINKKGFHIRY 1000
FHTD + K GF RY
Sbjct: 248 TFHTDMAVAKDGFSARY 264
Score = 135 bits (340), Expect = 2e-31
Identities = 90/275 (32%), Positives = 133/275 (48%), Gaps = 47/275 (17%)
Query: 618 CGGLL-TKLNGTITTPGWPKEYPPNKNCVWQVVAPT-QYRISVKFE-FFELEGNEVCKYD 674
CGG L +K G IT+PG+P++YP ++NC W V AP +I + F FE+E ++ CKYD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
++EI G S + L GK CG P I S + + I+F SD GF +
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY------- 139
Query: 735 SKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKY 794
E T GS +C + SP+G I SP +P+KY
Sbjct: 140 ---------EIFKT-GS--------------------EDCSKNFTSPNGTIESPGFPEKY 169
Query: 795 PSRKECTWEISATPGHRIKLAFSEFEIEQ------HQECAYDHLEVFDGETEKSPILGRL 848
P +CT+ I A P I L F F++E +C YD L+++DG P++G+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 849 CGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
CG K P L ++ + + F +D +V + GF A +
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 67.0 bits (162), Expect = 8e-11
Identities = 40/117 (34%), Positives = 63/117 (53%), Gaps = 6/117 (5%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVS-ERGSRLELSFQT-FEVEEEADC 944
CGGRL ++ Y + +YP +CEW++ + E ++ L+F FE+E+ DC
Sbjct: 28 CGGRLNSKDAG---YITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DC 83
Query: 945 GYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
YD++E+ DG +A LG+ CG+ P I S G + I F +D GF +RY+
Sbjct: 84 KYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYE 140
>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
Length = 901
Score = 152 bits (385), Expect = 1e-36
Identities = 90/276 (32%), Positives = 136/276 (49%), Gaps = 47/276 (17%)
Query: 462 CGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSE-SYHVGLTFQS-FEIERHDNCAYD 518
CGG + K+ G I SP YP DY + C W + E + + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
++E+RDG SE++ L+G+ CG P I S+ + L++KF SD AGF+ + E
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY-----EI 141
Query: 579 AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEY 638
K C + T NGTI +PG+P++Y
Sbjct: 142 FKTGSEDCSKN--------------------------------FTSPNGTIESPGFPEKY 169
Query: 639 PPNKNCVWQVVAPTQYRISVKFEFFELE------GNEVCKYDYVEIWSGLSSESKLHGKF 692
P N +C + ++A + I ++F F+LE G CKYD+++IW G+ L GK+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 693 CGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFF 728
CG + P + S + + F +D V+K GF A ++
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 150 bits (379), Expect = 6e-36
Identities = 85/246 (34%), Positives = 128/246 (52%), Gaps = 16/246 (6%)
Query: 347 PACGETLQESN-GNLSSPGFPNGYPSYTHCIWRV-SVTPGEKIVLNFTTMDLYKSSLCWY 404
P CG L + G ++SPG+P YPS+ +C W V + P +KIVLNF + C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 405 DYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI--- 461
D+IE+RDG + LLG+ CG+ P + S+ S ++I+F S G GF+ YE
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 462 ---CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD----- 513
C G I+SP +P+ Y +C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 514 --NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571
+C YD+L++ DG PLIG++CG P ++RS++ L + F +D V K GF+A +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 572 FKEEDE 577
+ E
Sbjct: 265 YLVHQE 270
Score = 142 bits (357), Expect = 2e-33
Identities = 81/257 (31%), Positives = 140/257 (54%), Gaps = 23/257 (8%)
Query: 762 LHDNKHDCK---EAECEQKIHSP-SGLITSPNWPDKYPSRKECTWEISAT-PGHRIKLAF 816
L+ ++H + + C +++S +G ITSP +P YPS + C W + A P +I L F
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNF 72
Query: 817 S-EFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQ 875
+ FEIE+H +C YD +E+ DG++E + +LG+ CGN P ++++G+ ++++F SD + Q
Sbjct: 73 NPHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQ 131
Query: 876 RKGFQ------ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRL 929
GF T S +C K + P F + YP +DC + ++++ +
Sbjct: 132 GAGFSLRYEIFKTGSEDCS---KNFTSPNGTIESPGFPE-KYPHNLDCTFTILAKPKMEI 187
Query: 930 ELSFQTFEVEE------EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
L F F++E E DC YD+++++DG+ +G++CG+ P E+ S + +
Sbjct: 188 ILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSL 247
Query: 984 HFHTDDTINKKGFHIRY 1000
FHTD + K GF RY
Sbjct: 248 TFHTDMAVAKDGFSARY 264
Score = 135 bits (340), Expect = 2e-31
Identities = 90/275 (32%), Positives = 133/275 (48%), Gaps = 47/275 (17%)
Query: 618 CGGLL-TKLNGTITTPGWPKEYPPNKNCVWQVVAPT-QYRISVKFE-FFELEGNEVCKYD 674
CGG L +K G IT+PG+P++YP ++NC W V AP +I + F FE+E ++ CKYD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
++EI G S + L GK CG P I S + + I+F SD GF +
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY------- 139
Query: 735 SKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKY 794
E T GS +C + SP+G I SP +P+KY
Sbjct: 140 ---------EIFKT-GS--------------------EDCSKNFTSPNGTIESPGFPEKY 169
Query: 795 PSRKECTWEISATPGHRIKLAFSEFEIEQ------HQECAYDHLEVFDGETEKSPILGRL 848
P +CT+ I A P I L F F++E +C YD L+++DG P++G+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 849 CGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
CG K P L ++ + + F +D +V + GF A +
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 67.0 bits (162), Expect = 8e-11
Identities = 40/117 (34%), Positives = 63/117 (53%), Gaps = 6/117 (5%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVS-ERGSRLELSFQT-FEVEEEADC 944
CGGRL ++ Y + +YP +CEW++ + E ++ L+F FE+E+ DC
Sbjct: 28 CGGRLNSKDAG---YITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DC 83
Query: 945 GYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
YD++E+ DG +A LG+ CG+ P I S G + I F +D GF +RY+
Sbjct: 84 KYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYE 140
>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
Length = 931
Score = 152 bits (385), Expect = 1e-36
Identities = 90/276 (32%), Positives = 136/276 (49%), Gaps = 47/276 (17%)
Query: 462 CGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSE-SYHVGLTFQS-FEIERHDNCAYD 518
CGG + K+ G I SP YP DY + C W + E + + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
++E+RDG SE++ L+G+ CG P I S+ + L++KF SD AGF+ + E
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY-----EI 141
Query: 579 AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEY 638
K C + T NGTI +PG+P++Y
Sbjct: 142 FKTGSEDCSKN--------------------------------FTSPNGTIESPGFPEKY 169
Query: 639 PPNKNCVWQVVAPTQYRISVKFEFFELE------GNEVCKYDYVEIWSGLSSESKLHGKF 692
P N +C + ++A + I ++F F+LE G CKYD+++IW G+ L GK+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 693 CGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFF 728
CG + P + S + + F +D V+K GF A ++
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 150 bits (379), Expect = 6e-36
Identities = 85/246 (34%), Positives = 128/246 (52%), Gaps = 16/246 (6%)
Query: 347 PACGETLQESN-GNLSSPGFPNGYPSYTHCIWRV-SVTPGEKIVLNFTTMDLYKSSLCWY 404
P CG L + G ++SPG+P YPS+ +C W V + P +KIVLNF + C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 405 DYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI--- 461
D+IE+RDG + LLG+ CG+ P + S+ S ++I+F S G GF+ YE
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 462 ---CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD----- 513
C G I+SP +P+ Y +C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 514 --NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571
+C YD+L++ DG PLIG++CG P ++RS++ L + F +D V K GF+A +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 572 FKEEDE 577
+ E
Sbjct: 265 YLVHQE 270
Score = 142 bits (357), Expect = 2e-33
Identities = 81/257 (31%), Positives = 140/257 (54%), Gaps = 23/257 (8%)
Query: 762 LHDNKHDCK---EAECEQKIHSP-SGLITSPNWPDKYPSRKECTWEISAT-PGHRIKLAF 816
L+ ++H + + C +++S +G ITSP +P YPS + C W + A P +I L F
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNF 72
Query: 817 S-EFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQ 875
+ FEIE+H +C YD +E+ DG++E + +LG+ CGN P ++++G+ ++++F SD + Q
Sbjct: 73 NPHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQ 131
Query: 876 RKGFQ------ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRL 929
GF T S +C K + P F + YP +DC + ++++ +
Sbjct: 132 GAGFSLRYEIFKTGSEDCS---KNFTSPNGTIESPGFPE-KYPHNLDCTFTILAKPKMEI 187
Query: 930 ELSFQTFEVEE------EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
L F F++E E DC YD+++++DG+ +G++CG+ P E+ S + +
Sbjct: 188 ILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSL 247
Query: 984 HFHTDDTINKKGFHIRY 1000
FHTD + K GF RY
Sbjct: 248 TFHTDMAVAKDGFSARY 264
Score = 135 bits (340), Expect = 2e-31
Identities = 90/275 (32%), Positives = 133/275 (48%), Gaps = 47/275 (17%)
Query: 618 CGGLL-TKLNGTITTPGWPKEYPPNKNCVWQVVAPT-QYRISVKFE-FFELEGNEVCKYD 674
CGG L +K G IT+PG+P++YP ++NC W V AP +I + F FE+E ++ CKYD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
++EI G S + L GK CG P I S + + I+F SD GF +
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY------- 139
Query: 735 SKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKY 794
E T GS +C + SP+G I SP +P+KY
Sbjct: 140 ---------EIFKT-GS--------------------EDCSKNFTSPNGTIESPGFPEKY 169
Query: 795 PSRKECTWEISATPGHRIKLAFSEFEIEQ------HQECAYDHLEVFDGETEKSPILGRL 848
P +CT+ I A P I L F F++E +C YD L+++DG P++G+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 849 CGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
CG K P L ++ + + F +D +V + GF A +
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 67.0 bits (162), Expect = 8e-11
Identities = 40/117 (34%), Positives = 63/117 (53%), Gaps = 6/117 (5%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVS-ERGSRLELSFQT-FEVEEEADC 944
CGGRL ++ Y + +YP +CEW++ + E ++ L+F FE+E+ DC
Sbjct: 28 CGGRLNSKDAG---YITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DC 83
Query: 945 GYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
YD++E+ DG +A LG+ CG+ P I S G + I F +D GF +RY+
Sbjct: 84 KYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYE 140
>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
Length = 555
Score = 152 bits (385), Expect = 1e-36
Identities = 90/276 (32%), Positives = 136/276 (49%), Gaps = 47/276 (17%)
Query: 462 CGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSE-SYHVGLTFQS-FEIERHDNCAYD 518
CGG + K+ G I SP YP DY + C W + E + + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
++E+RDG SE++ L+G+ CG P I S+ + L++KF SD AGF+ + E
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY-----EI 141
Query: 579 AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEY 638
K C + T NGTI +PG+P++Y
Sbjct: 142 FKTGSEDCSKN--------------------------------FTSPNGTIESPGFPEKY 169
Query: 639 PPNKNCVWQVVAPTQYRISVKFEFFELE------GNEVCKYDYVEIWSGLSSESKLHGKF 692
P N +C + ++A + I ++F F+LE G CKYD+++IW G+ L GK+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 693 CGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFF 728
CG + P + S + + F +D V+K GF A ++
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 150 bits (379), Expect = 6e-36
Identities = 85/246 (34%), Positives = 128/246 (52%), Gaps = 16/246 (6%)
Query: 347 PACGETLQESN-GNLSSPGFPNGYPSYTHCIWRV-SVTPGEKIVLNFTTMDLYKSSLCWY 404
P CG L + G ++SPG+P YPS+ +C W V + P +KIVLNF + C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 405 DYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI--- 461
D+IE+RDG + LLG+ CG+ P + S+ S ++I+F S G GF+ YE
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 462 ---CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD----- 513
C G I+SP +P+ Y +C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 514 --NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571
+C YD+L++ DG PLIG++CG P ++RS++ L + F +D V K GF+A +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 572 FKEEDE 577
+ E
Sbjct: 265 YLVHQE 270
Score = 142 bits (357), Expect = 2e-33
Identities = 81/257 (31%), Positives = 140/257 (54%), Gaps = 23/257 (8%)
Query: 762 LHDNKHDCK---EAECEQKIHSP-SGLITSPNWPDKYPSRKECTWEISAT-PGHRIKLAF 816
L+ ++H + + C +++S +G ITSP +P YPS + C W + A P +I L F
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNF 72
Query: 817 S-EFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQ 875
+ FEIE+H +C YD +E+ DG++E + +LG+ CGN P ++++G+ ++++F SD + Q
Sbjct: 73 NPHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQ 131
Query: 876 RKGFQ------ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRL 929
GF T S +C K + P F + YP +DC + ++++ +
Sbjct: 132 GAGFSLRYEIFKTGSEDCS---KNFTSPNGTIESPGFPE-KYPHNLDCTFTILAKPKMEI 187
Query: 930 ELSFQTFEVEE------EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
L F F++E E DC YD+++++DG+ +G++CG+ P E+ S + +
Sbjct: 188 ILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSL 247
Query: 984 HFHTDDTINKKGFHIRY 1000
FHTD + K GF RY
Sbjct: 248 TFHTDMAVAKDGFSARY 264
Score = 135 bits (340), Expect = 2e-31
Identities = 90/275 (32%), Positives = 133/275 (48%), Gaps = 47/275 (17%)
Query: 618 CGGLL-TKLNGTITTPGWPKEYPPNKNCVWQVVAPT-QYRISVKFE-FFELEGNEVCKYD 674
CGG L +K G IT+PG+P++YP ++NC W V AP +I + F FE+E ++ CKYD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
++EI G S + L GK CG P I S + + I+F SD GF +
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY------- 139
Query: 735 SKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKY 794
E T GS +C + SP+G I SP +P+KY
Sbjct: 140 ---------EIFKT-GS--------------------EDCSKNFTSPNGTIESPGFPEKY 169
Query: 795 PSRKECTWEISATPGHRIKLAFSEFEIEQ------HQECAYDHLEVFDGETEKSPILGRL 848
P +CT+ I A P I L F F++E +C YD L+++DG P++G+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 849 CGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
CG K P L ++ + + F +D +V + GF A +
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 67.0 bits (162), Expect = 8e-11
Identities = 40/117 (34%), Positives = 63/117 (53%), Gaps = 6/117 (5%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVS-ERGSRLELSFQT-FEVEEEADC 944
CGGRL ++ Y + +YP +CEW++ + E ++ L+F FE+E+ DC
Sbjct: 28 CGGRLNSKDAG---YITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DC 83
Query: 945 GYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
YD++E+ DG +A LG+ CG+ P I S G + I F +D GF +RY+
Sbjct: 84 KYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYE 140
>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
Length = 906
Score = 152 bits (385), Expect = 1e-36
Identities = 90/276 (32%), Positives = 136/276 (49%), Gaps = 47/276 (17%)
Query: 462 CGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSE-SYHVGLTFQS-FEIERHDNCAYD 518
CGG + K+ G I SP YP DY + C W + E + + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
++E+RDG SE++ L+G+ CG P I S+ + L++KF SD AGF+ + E
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY-----EI 141
Query: 579 AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEY 638
K C + T NGTI +PG+P++Y
Sbjct: 142 FKTGSEDCSKN--------------------------------FTSPNGTIESPGFPEKY 169
Query: 639 PPNKNCVWQVVAPTQYRISVKFEFFELE------GNEVCKYDYVEIWSGLSSESKLHGKF 692
P N +C + ++A + I ++F F+LE G CKYD+++IW G+ L GK+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 693 CGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFF 728
CG + P + S + + F +D V+K GF A ++
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 150 bits (379), Expect = 6e-36
Identities = 85/246 (34%), Positives = 128/246 (52%), Gaps = 16/246 (6%)
Query: 347 PACGETLQESN-GNLSSPGFPNGYPSYTHCIWRV-SVTPGEKIVLNFTTMDLYKSSLCWY 404
P CG L + G ++SPG+P YPS+ +C W V + P +KIVLNF + C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 405 DYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI--- 461
D+IE+RDG + LLG+ CG+ P + S+ S ++I+F S G GF+ YE
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 462 ---CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD----- 513
C G I+SP +P+ Y +C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 514 --NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571
+C YD+L++ DG PLIG++CG P ++RS++ L + F +D V K GF+A +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 572 FKEEDE 577
+ E
Sbjct: 265 YLVHQE 270
Score = 142 bits (357), Expect = 2e-33
Identities = 81/257 (31%), Positives = 140/257 (54%), Gaps = 23/257 (8%)
Query: 762 LHDNKHDCK---EAECEQKIHSP-SGLITSPNWPDKYPSRKECTWEISAT-PGHRIKLAF 816
L+ ++H + + C +++S +G ITSP +P YPS + C W + A P +I L F
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNF 72
Query: 817 S-EFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQ 875
+ FEIE+H +C YD +E+ DG++E + +LG+ CGN P ++++G+ ++++F SD + Q
Sbjct: 73 NPHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQ 131
Query: 876 RKGFQ------ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRL 929
GF T S +C K + P F + YP +DC + ++++ +
Sbjct: 132 GAGFSLRYEIFKTGSEDCS---KNFTSPNGTIESPGFPE-KYPHNLDCTFTILAKPKMEI 187
Query: 930 ELSFQTFEVEE------EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
L F F++E E DC YD+++++DG+ +G++CG+ P E+ S + +
Sbjct: 188 ILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSL 247
Query: 984 HFHTDDTINKKGFHIRY 1000
FHTD + K GF RY
Sbjct: 248 TFHTDMAVAKDGFSARY 264
Score = 135 bits (340), Expect = 2e-31
Identities = 90/275 (32%), Positives = 133/275 (48%), Gaps = 47/275 (17%)
Query: 618 CGGLL-TKLNGTITTPGWPKEYPPNKNCVWQVVAPT-QYRISVKFE-FFELEGNEVCKYD 674
CGG L +K G IT+PG+P++YP ++NC W V AP +I + F FE+E ++ CKYD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
++EI G S + L GK CG P I S + + I+F SD GF +
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY------- 139
Query: 735 SKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKY 794
E T GS +C + SP+G I SP +P+KY
Sbjct: 140 ---------EIFKT-GS--------------------EDCSKNFTSPNGTIESPGFPEKY 169
Query: 795 PSRKECTWEISATPGHRIKLAFSEFEIEQ------HQECAYDHLEVFDGETEKSPILGRL 848
P +CT+ I A P I L F F++E +C YD L+++DG P++G+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 849 CGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
CG K P L ++ + + F +D +V + GF A +
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 67.0 bits (162), Expect = 8e-11
Identities = 40/117 (34%), Positives = 63/117 (53%), Gaps = 6/117 (5%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVS-ERGSRLELSFQT-FEVEEEADC 944
CGGRL ++ Y + +YP +CEW++ + E ++ L+F FE+E+ DC
Sbjct: 28 CGGRLNSKDAG---YITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DC 83
Query: 945 GYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
YD++E+ DG +A LG+ CG+ P I S G + I F +D GF +RY+
Sbjct: 84 KYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYE 140
>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
Length = 926
Score = 152 bits (385), Expect = 1e-36
Identities = 90/276 (32%), Positives = 136/276 (49%), Gaps = 47/276 (17%)
Query: 462 CGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSE-SYHVGLTFQS-FEIERHDNCAYD 518
CGG + K+ G I SP YP DY + C W + E + + L F FEIE+HD C YD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC 578
++E+RDG SE++ L+G+ CG P I S+ + L++KF SD AGF+ + E
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY-----EI 141
Query: 579 AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEY 638
K C + T NGTI +PG+P++Y
Sbjct: 142 FKTGSEDCSKN--------------------------------FTSPNGTIESPGFPEKY 169
Query: 639 PPNKNCVWQVVAPTQYRISVKFEFFELE------GNEVCKYDYVEIWSGLSSESKLHGKF 692
P N +C + ++A + I ++F F+LE G CKYD+++IW G+ L GK+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 693 CGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFF 728
CG + P + S + + F +D V+K GF A ++
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
Score = 150 bits (379), Expect = 6e-36
Identities = 85/246 (34%), Positives = 128/246 (52%), Gaps = 16/246 (6%)
Query: 347 PACGETLQESN-GNLSSPGFPNGYPSYTHCIWRV-SVTPGEKIVLNFTTMDLYKSSLCWY 404
P CG L + G ++SPG+P YPS+ +C W V + P +KIVLNF + C Y
Sbjct: 26 PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
Query: 405 DYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI--- 461
D+IE+RDG + LLG+ CG+ P + S+ S ++I+F S G GF+ YE
Sbjct: 86 DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
Query: 462 ---CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD----- 513
C G I+SP +P+ Y +C + I + L F F++E HD
Sbjct: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
Query: 514 --NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571
+C YD+L++ DG PLIG++CG P ++RS++ L + F +D V K GF+A +
Sbjct: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Query: 572 FKEEDE 577
+ E
Sbjct: 265 YLVHQE 270
Score = 142 bits (357), Expect = 2e-33
Identities = 81/257 (31%), Positives = 140/257 (54%), Gaps = 23/257 (8%)
Query: 762 LHDNKHDCK---EAECEQKIHSP-SGLITSPNWPDKYPSRKECTWEISAT-PGHRIKLAF 816
L+ ++H + + C +++S +G ITSP +P YPS + C W + A P +I L F
Sbjct: 13 LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNF 72
Query: 817 S-EFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQ 875
+ FEIE+H +C YD +E+ DG++E + +LG+ CGN P ++++G+ ++++F SD + Q
Sbjct: 73 NPHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQ 131
Query: 876 RKGFQ------ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRL 929
GF T S +C K + P F + YP +DC + ++++ +
Sbjct: 132 GAGFSLRYEIFKTGSEDCS---KNFTSPNGTIESPGFPE-KYPHNLDCTFTILAKPKMEI 187
Query: 930 ELSFQTFEVEE------EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983
L F F++E E DC YD+++++DG+ +G++CG+ P E+ S + +
Sbjct: 188 ILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSL 247
Query: 984 HFHTDDTINKKGFHIRY 1000
FHTD + K GF RY
Sbjct: 248 TFHTDMAVAKDGFSARY 264
Score = 135 bits (340), Expect = 2e-31
Identities = 90/275 (32%), Positives = 133/275 (48%), Gaps = 47/275 (17%)
Query: 618 CGGLL-TKLNGTITTPGWPKEYPPNKNCVWQVVAPT-QYRISVKFE-FFELEGNEVCKYD 674
CGG L +K G IT+PG+P++YP ++NC W V AP +I + F FE+E ++ CKYD
Sbjct: 28 CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
Query: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734
++EI G S + L GK CG P I S + + I+F SD GF +
Sbjct: 87 FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY------- 139
Query: 735 SKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKY 794
E T GS +C + SP+G I SP +P+KY
Sbjct: 140 ---------EIFKT-GS--------------------EDCSKNFTSPNGTIESPGFPEKY 169
Query: 795 PSRKECTWEISATPGHRIKLAFSEFEIEQ------HQECAYDHLEVFDGETEKSPILGRL 848
P +CT+ I A P I L F F++E +C YD L+++DG P++G+
Sbjct: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
Query: 849 CGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
CG K P L ++ + + F +D +V + GF A +
Sbjct: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
Score = 67.0 bits (162), Expect = 8e-11
Identities = 40/117 (34%), Positives = 63/117 (53%), Gaps = 6/117 (5%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVS-ERGSRLELSFQT-FEVEEEADC 944
CGGRL ++ Y + +YP +CEW++ + E ++ L+F FE+E+ DC
Sbjct: 28 CGGRLNSKDAG---YITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DC 83
Query: 945 GYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
YD++E+ DG +A LG+ CG+ P I S G + I F +D GF +RY+
Sbjct: 84 KYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYE 140
>gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens]
Length = 1662
Score = 151 bits (381), Expect = 3e-36
Identities = 114/393 (29%), Positives = 176/393 (44%), Gaps = 54/393 (13%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L ++G SSP +P YP+ C+W + V G +I L F+ + L C +DY+E
Sbjct: 1015 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1074
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRK 468
+ DG S LLG+ C D ++ TS+ +RM I FRS ++ GF A Y +
Sbjct: 1075 IFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNSF------P 1127
Query: 469 NEGQIQSPNYPDDYRPMKECVWKITVSESYHVGL---------TFQSFEIE-RHDNCAYD 518
++ ++ N Y C ++ E YH G T Q E+ R C
Sbjct: 1128 SDATLRLVNLNSSYGL---CAGRV---EIYHGGTWGTVCDDSWTIQEAEVVCRQLGCG-- 1179
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIR--STSNTLWMKFVSDGTVNKAGFAANFFKEED 576
R ++ + G G +D+ T +TLW N+ F+ N ED
Sbjct: 1180 ----RAVSALGNAYFGSGSGPITLDDVECSGTESTLWQ------CRNRGWFSHNCNHRED 1229
Query: 577 ECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPK 636
C L+T P L R + + +CGG L++ +G ++P +P
Sbjct: 1230 AGVI-----CSGNHLST---------PAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPG 1275
Query: 637 EYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAE 696
YP N CVW + YR++V F +LEG C YDY+E++ G S L + C
Sbjct: 1276 NYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIEVFDGPYRSSPLIARVCDG- 1332
Query: 697 VPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS 729
TS N M I F SD++++++GF+A ++S
Sbjct: 1333 ARGSFTSSSNFMSIRFISDHSITRRGFRAEYYS 1365
Score = 91.3 bits (225), Expect = 4e-18
Identities = 41/114 (35%), Positives = 66/114 (57%), Gaps = 1/114 (0%)
Query: 772 AECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDH 831
+ C + SG +SP++P YP+ +C WEI G+RI L FS ++E H C++D+
Sbjct: 1013 SNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDY 1072
Query: 832 LEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHST 885
+E+FDG S +LG++C N ++ N+M + F SD S Q GF A +++
Sbjct: 1073 VEIFDGSLNSSLLLGKIC-NDTRQIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1125
Score = 82.4 bits (202), Expect = 2e-15
Identities = 38/110 (34%), Positives = 64/110 (58%), Gaps = 3/110 (2%)
Query: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
C + PSG +SP +P YP+ +C W+I +R+ + F + ++E C YD++E
Sbjct: 1257 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLE--GGCNYDYIE 1314
Query: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
VFDG SP++ R+C + ++ N M +RF+SD S+ R+GF+A +
Sbjct: 1315 VFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1363
Score = 74.3 bits (181), Expect = 5e-13
Identities = 41/111 (36%), Positives = 59/111 (53%), Gaps = 3/111 (2%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
+CG L + +G+ SSP +P YP+ C+W + V ++ + F D+ C YDYI
Sbjct: 1256 SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIF--RDVQLEGGCNYDYI 1313
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
EV DG +R SPL+ R C D TS+ + M I F S + +GF A Y
Sbjct: 1314 EVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1363
Score = 61.2 bits (147), Expect = 5e-09
Identities = 38/123 (30%), Positives = 59/123 (47%), Gaps = 7/123 (5%)
Query: 881 ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEE 940
A S+ CGG L S S+ + YP C W + G R+ L F ++E
Sbjct: 1009 ARPSSNCGGFLFYASGTFSSPSYPAY----YPNNAKCVWEIEVNSGYRINLGFSNLKLEA 1064
Query: 941 EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIY-SIGDSVLIHFHTDDTINKKGFHIR 999
+C +DYVE+FDG ++++ LG+ C +I+ S + + IHF +D + GF
Sbjct: 1065 HHNCSFDYVEIFDGSLNSSLLLGKICND--TRQIFTSSYNRMTIHFRSDISFQNTGFLAW 1122
Query: 1000 YKS 1002
Y S
Sbjct: 1123 YNS 1125
Score = 59.7 bits (143), Expect = 1e-08
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 7/124 (5%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG L S+P +S + F NYP C W + + R+ + F+ +V+ E C Y
Sbjct: 1257 CGGFL---SQPSGDFS-SPFYPGNYPNNAKCVWDIEVQNNYRVTVIFR--DVQLEGGCNY 1310
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYP 1006
DY+E+FDG ++ + R C G S + + I F +D +I ++GF Y S
Sbjct: 1311 DYIEVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSN 1369
Query: 1007 DTTH 1010
D+T+
Sbjct: 1370 DSTN 1373
>gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens]
Length = 1788
Score = 151 bits (381), Expect = 3e-36
Identities = 114/393 (29%), Positives = 176/393 (44%), Gaps = 54/393 (13%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L ++G SSP +P YP+ C+W + V G +I L F+ + L C +DY+E
Sbjct: 1141 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1200
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRK 468
+ DG S LLG+ C D ++ TS+ +RM I FRS ++ GF A Y +
Sbjct: 1201 IFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNSF------P 1253
Query: 469 NEGQIQSPNYPDDYRPMKECVWKITVSESYHVGL---------TFQSFEIE-RHDNCAYD 518
++ ++ N Y C ++ E YH G T Q E+ R C
Sbjct: 1254 SDATLRLVNLNSSYGL---CAGRV---EIYHGGTWGTVCDDSWTIQEAEVVCRQLGCG-- 1305
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIR--STSNTLWMKFVSDGTVNKAGFAANFFKEED 576
R ++ + G G +D+ T +TLW N+ F+ N ED
Sbjct: 1306 ----RAVSALGNAYFGSGSGPITLDDVECSGTESTLWQ------CRNRGWFSHNCNHRED 1355
Query: 577 ECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPK 636
C L+T P L R + + +CGG L++ +G ++P +P
Sbjct: 1356 AGVI-----CSGNHLST---------PAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPG 1401
Query: 637 EYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAE 696
YP N CVW + YR++V F +LEG C YDY+E++ G S L + C
Sbjct: 1402 NYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIEVFDGPYRSSPLIARVCDG- 1458
Query: 697 VPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS 729
TS N M I F SD++++++GF+A ++S
Sbjct: 1459 ARGSFTSSSNFMSIRFISDHSITRRGFRAEYYS 1491
Score = 91.3 bits (225), Expect = 4e-18
Identities = 41/114 (35%), Positives = 66/114 (57%), Gaps = 1/114 (0%)
Query: 772 AECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDH 831
+ C + SG +SP++P YP+ +C WEI G+RI L FS ++E H C++D+
Sbjct: 1139 SNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDY 1198
Query: 832 LEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHST 885
+E+FDG S +LG++C N ++ N+M + F SD S Q GF A +++
Sbjct: 1199 VEIFDGSLNSSLLLGKIC-NDTRQIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1251
Score = 82.4 bits (202), Expect = 2e-15
Identities = 38/110 (34%), Positives = 64/110 (58%), Gaps = 3/110 (2%)
Query: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
C + PSG +SP +P YP+ +C W+I +R+ + F + ++E C YD++E
Sbjct: 1383 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLE--GGCNYDYIE 1440
Query: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
VFDG SP++ R+C + ++ N M +RF+SD S+ R+GF+A +
Sbjct: 1441 VFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1489
Score = 74.3 bits (181), Expect = 5e-13
Identities = 41/111 (36%), Positives = 59/111 (53%), Gaps = 3/111 (2%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
+CG L + +G+ SSP +P YP+ C+W + V ++ + F D+ C YDYI
Sbjct: 1382 SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIF--RDVQLEGGCNYDYI 1439
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
EV DG +R SPL+ R C D TS+ + M I F S + +GF A Y
Sbjct: 1440 EVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1489
Score = 61.2 bits (147), Expect = 5e-09
Identities = 38/123 (30%), Positives = 59/123 (47%), Gaps = 7/123 (5%)
Query: 881 ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEE 940
A S+ CGG L S S+ + YP C W + G R+ L F ++E
Sbjct: 1135 ARPSSNCGGFLFYASGTFSSPSYPAY----YPNNAKCVWEIEVNSGYRINLGFSNLKLEA 1190
Query: 941 EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIY-SIGDSVLIHFHTDDTINKKGFHIR 999
+C +DYVE+FDG ++++ LG+ C +I+ S + + IHF +D + GF
Sbjct: 1191 HHNCSFDYVEIFDGSLNSSLLLGKICND--TRQIFTSSYNRMTIHFRSDISFQNTGFLAW 1248
Query: 1000 YKS 1002
Y S
Sbjct: 1249 YNS 1251
Score = 59.7 bits (143), Expect = 1e-08
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 7/124 (5%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG L S+P +S + F NYP C W + + R+ + F+ +V+ E C Y
Sbjct: 1383 CGGFL---SQPSGDFS-SPFYPGNYPNNAKCVWDIEVQNNYRVTVIFR--DVQLEGGCNY 1436
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYP 1006
DY+E+FDG ++ + R C G S + + I F +D +I ++GF Y S
Sbjct: 1437 DYIEVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSN 1495
Query: 1007 DTTH 1010
D+T+
Sbjct: 1496 DSTN 1499
>gi|148539844 deleted in malignant brain tumors 1 isoform c precursor
[Homo sapiens]
Length = 2403
Score = 151 bits (381), Expect = 3e-36
Identities = 114/393 (29%), Positives = 176/393 (44%), Gaps = 54/393 (13%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L ++G SSP +P YP+ C+W + V G +I L F+ + L C +DY+E
Sbjct: 1756 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1815
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRK 468
+ DG S LLG+ C D ++ TS+ +RM I FRS ++ GF A Y +
Sbjct: 1816 IFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNSF------P 1868
Query: 469 NEGQIQSPNYPDDYRPMKECVWKITVSESYHVGL---------TFQSFEIE-RHDNCAYD 518
++ ++ N Y C ++ E YH G T Q E+ R C
Sbjct: 1869 SDATLRLVNLNSSYGL---CAGRV---EIYHGGTWGTVCDDSWTIQEAEVVCRQLGCG-- 1920
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIR--STSNTLWMKFVSDGTVNKAGFAANFFKEED 576
R ++ + G G +D+ T +TLW N+ F+ N ED
Sbjct: 1921 ----RAVSALGNAYFGSGSGPITLDDVECSGTESTLWQ------CRNRGWFSHNCNHRED 1970
Query: 577 ECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPK 636
C L+T P L R + + +CGG L++ +G ++P +P
Sbjct: 1971 AGVI-----CSGNHLST---------PAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPG 2016
Query: 637 EYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAE 696
YP N CVW + YR++V F +LEG C YDY+E++ G S L + C
Sbjct: 2017 NYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIEVFDGPYRSSPLIARVCDG- 2073
Query: 697 VPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS 729
TS N M I F SD++++++GF+A ++S
Sbjct: 2074 ARGSFTSSSNFMSIRFISDHSITRRGFRAEYYS 2106
Score = 91.3 bits (225), Expect = 4e-18
Identities = 41/114 (35%), Positives = 66/114 (57%), Gaps = 1/114 (0%)
Query: 772 AECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDH 831
+ C + SG +SP++P YP+ +C WEI G+RI L FS ++E H C++D+
Sbjct: 1754 SNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDY 1813
Query: 832 LEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHST 885
+E+FDG S +LG++C N ++ N+M + F SD S Q GF A +++
Sbjct: 1814 VEIFDGSLNSSLLLGKIC-NDTRQIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1866
Score = 82.4 bits (202), Expect = 2e-15
Identities = 38/110 (34%), Positives = 64/110 (58%), Gaps = 3/110 (2%)
Query: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
C + PSG +SP +P YP+ +C W+I +R+ + F + ++E C YD++E
Sbjct: 1998 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLE--GGCNYDYIE 2055
Query: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
VFDG SP++ R+C + ++ N M +RF+SD S+ R+GF+A +
Sbjct: 2056 VFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 2104
Score = 74.3 bits (181), Expect = 5e-13
Identities = 41/111 (36%), Positives = 59/111 (53%), Gaps = 3/111 (2%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
+CG L + +G+ SSP +P YP+ C+W + V ++ + F D+ C YDYI
Sbjct: 1997 SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIF--RDVQLEGGCNYDYI 2054
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
EV DG +R SPL+ R C D TS+ + M I F S + +GF A Y
Sbjct: 2055 EVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 2104
Score = 61.2 bits (147), Expect = 5e-09
Identities = 38/123 (30%), Positives = 59/123 (47%), Gaps = 7/123 (5%)
Query: 881 ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEE 940
A S+ CGG L S S+ + YP C W + G R+ L F ++E
Sbjct: 1750 ARPSSNCGGFLFYASGTFSSPSYPAY----YPNNAKCVWEIEVNSGYRINLGFSNLKLEA 1805
Query: 941 EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIY-SIGDSVLIHFHTDDTINKKGFHIR 999
+C +DYVE+FDG ++++ LG+ C +I+ S + + IHF +D + GF
Sbjct: 1806 HHNCSFDYVEIFDGSLNSSLLLGKICND--TRQIFTSSYNRMTIHFRSDISFQNTGFLAW 1863
Query: 1000 YKS 1002
Y S
Sbjct: 1864 YNS 1866
Score = 59.7 bits (143), Expect = 1e-08
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 7/124 (5%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG L S+P +S + F NYP C W + + R+ + F+ +V+ E C Y
Sbjct: 1998 CGGFL---SQPSGDFS-SPFYPGNYPNNAKCVWDIEVQNNYRVTVIFR--DVQLEGGCNY 2051
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYP 1006
DY+E+FDG ++ + R C G S + + I F +D +I ++GF Y S
Sbjct: 2052 DYIEVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSN 2110
Query: 1007 DTTH 1010
D+T+
Sbjct: 2111 DSTN 2114
>gi|148539842 deleted in malignant brain tumors 1 isoform b precursor
[Homo sapiens]
Length = 2413
Score = 151 bits (381), Expect = 3e-36
Identities = 114/393 (29%), Positives = 176/393 (44%), Gaps = 54/393 (13%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L ++G SSP +P YP+ C+W + V G +I L F+ + L C +DY+E
Sbjct: 1766 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1825
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRK 468
+ DG S LLG+ C D ++ TS+ +RM I FRS ++ GF A Y +
Sbjct: 1826 IFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNSF------P 1878
Query: 469 NEGQIQSPNYPDDYRPMKECVWKITVSESYHVGL---------TFQSFEIE-RHDNCAYD 518
++ ++ N Y C ++ E YH G T Q E+ R C
Sbjct: 1879 SDATLRLVNLNSSYGL---CAGRV---EIYHGGTWGTVCDDSWTIQEAEVVCRQLGCG-- 1930
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIR--STSNTLWMKFVSDGTVNKAGFAANFFKEED 576
R ++ + G G +D+ T +TLW N+ F+ N ED
Sbjct: 1931 ----RAVSALGNAYFGSGSGPITLDDVECSGTESTLWQ------CRNRGWFSHNCNHRED 1980
Query: 577 ECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPK 636
C L+T P L R + + +CGG L++ +G ++P +P
Sbjct: 1981 AGVI-----CSGNHLST---------PAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPG 2026
Query: 637 EYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAE 696
YP N CVW + YR++V F +LEG C YDY+E++ G S L + C
Sbjct: 2027 NYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIEVFDGPYRSSPLIARVCDG- 2083
Query: 697 VPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS 729
TS N M I F SD++++++GF+A ++S
Sbjct: 2084 ARGSFTSSSNFMSIRFISDHSITRRGFRAEYYS 2116
Score = 91.3 bits (225), Expect = 4e-18
Identities = 41/114 (35%), Positives = 66/114 (57%), Gaps = 1/114 (0%)
Query: 772 AECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDH 831
+ C + SG +SP++P YP+ +C WEI G+RI L FS ++E H C++D+
Sbjct: 1764 SNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDY 1823
Query: 832 LEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHST 885
+E+FDG S +LG++C N ++ N+M + F SD S Q GF A +++
Sbjct: 1824 VEIFDGSLNSSLLLGKIC-NDTRQIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1876
Score = 82.4 bits (202), Expect = 2e-15
Identities = 38/110 (34%), Positives = 64/110 (58%), Gaps = 3/110 (2%)
Query: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
C + PSG +SP +P YP+ +C W+I +R+ + F + ++E C YD++E
Sbjct: 2008 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLE--GGCNYDYIE 2065
Query: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
VFDG SP++ R+C + ++ N M +RF+SD S+ R+GF+A +
Sbjct: 2066 VFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 2114
Score = 74.3 bits (181), Expect = 5e-13
Identities = 41/111 (36%), Positives = 59/111 (53%), Gaps = 3/111 (2%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
+CG L + +G+ SSP +P YP+ C+W + V ++ + F D+ C YDYI
Sbjct: 2007 SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIF--RDVQLEGGCNYDYI 2064
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
EV DG +R SPL+ R C D TS+ + M I F S + +GF A Y
Sbjct: 2065 EVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 2114
Score = 61.2 bits (147), Expect = 5e-09
Identities = 38/123 (30%), Positives = 59/123 (47%), Gaps = 7/123 (5%)
Query: 881 ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEE 940
A S+ CGG L S S+ + YP C W + G R+ L F ++E
Sbjct: 1760 ARPSSNCGGFLFYASGTFSSPSYPAY----YPNNAKCVWEIEVNSGYRINLGFSNLKLEA 1815
Query: 941 EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIY-SIGDSVLIHFHTDDTINKKGFHIR 999
+C +DYVE+FDG ++++ LG+ C +I+ S + + IHF +D + GF
Sbjct: 1816 HHNCSFDYVEIFDGSLNSSLLLGKICND--TRQIFTSSYNRMTIHFRSDISFQNTGFLAW 1873
Query: 1000 YKS 1002
Y S
Sbjct: 1874 YNS 1876
Score = 59.7 bits (143), Expect = 1e-08
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 7/124 (5%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG L S+P +S + F NYP C W + + R+ + F+ +V+ E C Y
Sbjct: 2008 CGGFL---SQPSGDFS-SPFYPGNYPNNAKCVWDIEVQNNYRVTVIFR--DVQLEGGCNY 2061
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYP 1006
DY+E+FDG ++ + R C G S + + I F +D +I ++GF Y S
Sbjct: 2062 DYIEVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSN 2120
Query: 1007 DTTH 1010
D+T+
Sbjct: 2121 DSTN 2124
>gi|148539840 deleted in malignant brain tumors 1 isoform a precursor
[Homo sapiens]
Length = 1785
Score = 151 bits (381), Expect = 3e-36
Identities = 114/393 (29%), Positives = 176/393 (44%), Gaps = 54/393 (13%)
Query: 349 CGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIE 408
CG L ++G SSP +P YP+ C+W + V G +I L F+ + L C +DY+E
Sbjct: 1138 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1197
Query: 409 VRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGGEIRK 468
+ DG S LLG+ C D ++ TS+ +RM I FRS ++ GF A Y +
Sbjct: 1198 IFDGSLNSSLLLGKICNDTR-QIFTSSYNRMTIHFRSDISFQNTGFLAWYNSF------P 1250
Query: 469 NEGQIQSPNYPDDYRPMKECVWKITVSESYHVGL---------TFQSFEIE-RHDNCAYD 518
++ ++ N Y C ++ E YH G T Q E+ R C
Sbjct: 1251 SDATLRLVNLNSSYGL---CAGRV---EIYHGGTWGTVCDDSWTIQEAEVVCRQLGCG-- 1302
Query: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIR--STSNTLWMKFVSDGTVNKAGFAANFFKEED 576
R ++ + G G +D+ T +TLW N+ F+ N ED
Sbjct: 1303 ----RAVSALGNAYFGSGSGPITLDDVECSGTESTLWQ------CRNRGWFSHNCNHRED 1352
Query: 577 ECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPK 636
C L+T P L R + + +CGG L++ +G ++P +P
Sbjct: 1353 AGVI-----CSGNHLST---------PAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPG 1398
Query: 637 EYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGAE 696
YP N CVW + YR++V F +LEG C YDY+E++ G S L + C
Sbjct: 1399 NYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CNYDYIEVFDGPYRSSPLIARVCDG- 1455
Query: 697 VPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFS 729
TS N M I F SD++++++GF+A ++S
Sbjct: 1456 ARGSFTSSSNFMSIRFISDHSITRRGFRAEYYS 1488
Score = 91.3 bits (225), Expect = 4e-18
Identities = 41/114 (35%), Positives = 66/114 (57%), Gaps = 1/114 (0%)
Query: 772 AECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDH 831
+ C + SG +SP++P YP+ +C WEI G+RI L FS ++E H C++D+
Sbjct: 1136 SNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDY 1195
Query: 832 LEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHST 885
+E+FDG S +LG++C N ++ N+M + F SD S Q GF A +++
Sbjct: 1196 VEIFDGSLNSSLLLGKIC-NDTRQIFTSSYNRMTIHFRSDISFQNTGFLAWYNS 1248
Score = 82.4 bits (202), Expect = 2e-15
Identities = 38/110 (34%), Positives = 64/110 (58%), Gaps = 3/110 (2%)
Query: 774 CEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLE 833
C + PSG +SP +P YP+ +C W+I +R+ + F + ++E C YD++E
Sbjct: 1380 CGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLE--GGCNYDYIE 1437
Query: 834 VFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883
VFDG SP++ R+C + ++ N M +RF+SD S+ R+GF+A +
Sbjct: 1438 VFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1486
Score = 74.3 bits (181), Expect = 5e-13
Identities = 41/111 (36%), Positives = 59/111 (53%), Gaps = 3/111 (2%)
Query: 348 ACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYI 407
+CG L + +G+ SSP +P YP+ C+W + V ++ + F D+ C YDYI
Sbjct: 1379 SCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIF--RDVQLEGGCNYDYI 1436
Query: 408 EVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVY 458
EV DG +R SPL+ R C D TS+ + M I F S + +GF A Y
Sbjct: 1437 EVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1486
Score = 61.2 bits (147), Expect = 5e-09
Identities = 38/123 (30%), Positives = 59/123 (47%), Gaps = 7/123 (5%)
Query: 881 ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEE 940
A S+ CGG L S S+ + YP C W + G R+ L F ++E
Sbjct: 1132 ARPSSNCGGFLFYASGTFSSPSYPAY----YPNNAKCVWEIEVNSGYRINLGFSNLKLEA 1187
Query: 941 EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIY-SIGDSVLIHFHTDDTINKKGFHIR 999
+C +DYVE+FDG ++++ LG+ C +I+ S + + IHF +D + GF
Sbjct: 1188 HHNCSFDYVEIFDGSLNSSLLLGKICND--TRQIFTSSYNRMTIHFRSDISFQNTGFLAW 1245
Query: 1000 YKS 1002
Y S
Sbjct: 1246 YNS 1248
Score = 59.7 bits (143), Expect = 1e-08
Identities = 39/124 (31%), Positives = 62/124 (50%), Gaps = 7/124 (5%)
Query: 887 CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGY 946
CGG L S+P +S + F NYP C W + + R+ + F+ +V+ E C Y
Sbjct: 1380 CGGFL---SQPSGDFS-SPFYPGNYPNNAKCVWDIEVQNNYRVTVIFR--DVQLEGGCNY 1433
Query: 947 DYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYP 1006
DY+E+FDG ++ + R C G S + + I F +D +I ++GF Y S
Sbjct: 1434 DYIEVFDGPYRSSPLIARVC-DGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSN 1492
Query: 1007 DTTH 1010
D+T+
Sbjct: 1493 DSTN 1496
>gi|66347875 complement component 1, r subcomponent [Homo sapiens]
Length = 705
Score = 149 bits (376), Expect = 1e-35
Identities = 97/291 (33%), Positives = 150/291 (51%), Gaps = 37/291 (12%)
Query: 624 KLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLS 683
KL G +T+P +PK YP N + PT YR+ + F+ F+LE +E C YDYV+I S
Sbjct: 24 KLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI----S 79
Query: 684 SESKLHGKFCGA--------EVPEVITSQFNNMRIEFKSDNTVSK-------KGFKAHFF 728
++ K G+FCG + SQ N M + F +D + + KGF A++
Sbjct: 80 ADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQ 139
Query: 729 S-DKDEC-SKDNGG-------CQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIH 779
+ D DEC S+ G CQH C N +G Y C CR G+ L +++H C +AEC +++
Sbjct: 140 AVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSC-QAECSSELY 198
Query: 780 S-PSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSE-FEIEQHQE--CAYDHLEVF 835
+ SG I+S +P YP C + I G + L F E F+I+ HQ+ C YD L+++
Sbjct: 199 TEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIY 258
Query: 836 DGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHSTE 886
+G CG + P L + N + + F +D S +G++ ++TE
Sbjct: 259 ----ANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTE 305
Score = 133 bits (335), Expect = 7e-31
Identities = 91/302 (30%), Positives = 150/302 (49%), Gaps = 38/302 (12%)
Query: 463 GGEI---RKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDY 519
GG I +K G++ SP +P Y E ITV Y V L FQ F++E + C YDY
Sbjct: 16 GGSIPIPQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDY 75
Query: 520 LEVRDGTSENSPLIGRFCGY--------DKPEDIRSTSNTLWMKFVSD------GTVN-K 564
+++ S + +GRFCG ++ S N + + F +D GT+
Sbjct: 76 VKI----SADKKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFY 131
Query: 565 AGFAANFFKEE-DECAKPDRGG-------CEQRCLNTLGSYQCACEPGYELGPDRRSCEA 616
GF A + + DECA + G C+ C N +G Y C+C PGYEL DR SC+A
Sbjct: 132 KGFLAYYQAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQA 191
Query: 617 ACGG-LLTKLNGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKF-EFFELEGNEV--CK 672
C L T+ +G I++ +P+ YPP+ C + + + +KF E F+++ ++ C
Sbjct: 192 ECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCP 251
Query: 673 YDYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKD 732
YD ++I+ + K G+FCG + P + + N + + F +D + +G+K + ++
Sbjct: 252 YDQLQIY----ANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEII 307
Query: 733 EC 734
+C
Sbjct: 308 KC 309
Score = 90.1 bits (222), Expect = 9e-18
Identities = 73/285 (25%), Positives = 127/285 (44%), Gaps = 76/285 (26%)
Query: 783 GLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKS 842
G +TSP +P YP+ E T I+ G+R+KL F +F++E + C YD++++ +KS
Sbjct: 27 GEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKI--SADKKS 84
Query: 843 PILGRLCGNKIPDPL---------VATGNKMFVRFVSDASVQRKG-----------FQAT 882
LGR CG ++ PL ++ GNKM + F +D S + G +QA
Sbjct: 85 --LGRFCG-QLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAV 141
Query: 883 HSTECGGRLK-AESKPR-------------------------------------DLYSHA 904
EC R K E P+ +LY+ A
Sbjct: 142 DLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEA 201
Query: 905 QFG------DNNYPGQVDCEWLLVSERGSRLELSF-QTFEVEE--EADCGYDYVELFDGL 955
+YP + C + + ERG L L F + F++++ + C YD ++++
Sbjct: 202 SGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIY--- 258
Query: 956 DSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRY 1000
+ +G FCG P ++ + ++V + F TD++ + +G+ +RY
Sbjct: 259 -ANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRY 302
Score = 77.8 bits (190), Expect = 5e-14
Identities = 81/330 (24%), Positives = 127/330 (38%), Gaps = 84/330 (25%)
Query: 354 QESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGY 413
Q+ G ++SP FP YP+ ++V G ++ L F DL S C+YDY+++
Sbjct: 23 QKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISAD- 81
Query: 414 WRKSPLLGRFC---GDKL-----PEVLTSTDSRMWIEFRSSSN-------WVGKGFAAVY 458
+KS LGRFC G L + S ++M + F + + KGF A Y
Sbjct: 82 -KKS--LGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYY 138
Query: 459 EAI---------------------------------------------------CGGEI- 466
+A+ C E+
Sbjct: 139 QAVDLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELY 198
Query: 467 RKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTF-QSFEIERHD--NCAYDYLEVR 523
+ G I S YP Y P C + I V + L F + F+I+ H +C YD L++
Sbjct: 199 TEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIY 258
Query: 524 DGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKPDR 583
N IG FCG +P D+ ++SN + + F +D + + G+ + E +C +P
Sbjct: 259 ----ANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKT 314
Query: 584 GGCEQRCLNTLGSYQ------CACEPGYEL 607
N YQ C+ GY+L
Sbjct: 315 LDEFTIIQNLQPQYQFRDYFIATCKQGYQL 344
Score = 54.3 bits (129), Expect = 6e-07
Identities = 33/99 (33%), Positives = 50/99 (50%), Gaps = 12/99 (12%)
Query: 911 YPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDYVELFDGLDSTAVGLGRFCG--- 967
YP + ++ G R++L FQ F++E C YDYV+ + + LGRFCG
Sbjct: 38 YPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVK----ISADKKSLGRFCGQLG 93
Query: 968 ---SGPP--EEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001
PP +E S G+ +L+ FHTD + + G + YK
Sbjct: 94 SPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYK 132
Score = 40.4 bits (93), Expect = 0.009
Identities = 27/126 (21%), Positives = 56/126 (44%), Gaps = 7/126 (5%)
Query: 336 DIAQARKLYRCPACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTT-- 393
++ + R + E E++G +SS +P YP C + + V G + L F
Sbjct: 181 ELQEDRHSCQAECSSELYTEASGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPF 240
Query: 394 -MDLYKSSLCWYDYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGK 452
+D ++ C YD +++ + +G FCG + P L ++ + + + F + + +
Sbjct: 241 DIDDHQQVHCPYDQLQI----YANGKNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSR 296
Query: 453 GFAAVY 458
G+ Y
Sbjct: 297 GWKLRY 302
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.138 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,257,004
Number of Sequences: 37866
Number of extensions: 2172046
Number of successful extensions: 8501
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 4897
Number of HSP's gapped (non-prelim): 2432
length of query: 1013
length of database: 18,247,518
effective HSP length: 112
effective length of query: 901
effective length of database: 14,006,526
effective search space: 12619879926
effective search space used: 12619879926
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.