Search of human proteins with 22547186

Search of human proteins with 22547186

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|22547186 serine hydroxymethyltransferase 1 (soluble) isoform
1 [Homo sapiens]
         (483 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|22547186 serine hydroxymethyltransferase 1 (soluble) isoform ...   975   0.0  
gi|22547189 serine hydroxymethyltransferase 1 (soluble) isoform ...   878   0.0  
gi|19923315 serine hydroxymethyltransferase 2 (mitochondrial) [H...   614   e-176
gi|195546900 suppressor of Ty 5 homolog isoform a [Homo sapiens]       33   0.58 
gi|161169023 suppressor of Ty 5 homolog isoform a [Homo sapiens]       33   0.58 
gi|20149524 suppressor of Ty 5 homolog isoform a [Homo sapiens]        33   0.58 
gi|27777632 solute carrier family 9, isoform A1 [Homo sapiens]         29   8.3  
gi|195546902 suppressor of Ty 5 homolog isoform b [Homo sapiens]       29   8.3  

>gi|22547186 serine hydroxymethyltransferase 1 (soluble) isoform 1
           [Homo sapiens]
          Length = 483

 Score =  975 bits (2521), Expect = 0.0
 Identities = 483/483 (100%), Positives = 483/483 (100%)

Query: 1   MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA 60
           MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
Sbjct: 1   MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA 60

Query: 61  VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG 120
           VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
Sbjct: 61  VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG 120

Query: 121 SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY 180
           SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
Sbjct: 121 SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY 180

Query: 181 INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV 240
           INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
Sbjct: 181 INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV 240

Query: 241 VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL 300
           VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL
Sbjct: 241 VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL 300

Query: 301 QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL 360
           QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
Sbjct: 301 QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL 360

Query: 361 VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK 420
           VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
Sbjct: 361 VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK 420

Query: 421 VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL 480
           VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
Sbjct: 421 VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL 480

Query: 481 PDF 483
           PDF
Sbjct: 481 PDF 483


>gi|22547189 serine hydroxymethyltransferase 1 (soluble) isoform 2
           [Homo sapiens]
          Length = 444

 Score =  878 bits (2268), Expect = 0.0
 Identities = 444/483 (91%), Positives = 444/483 (91%), Gaps = 39/483 (8%)

Query: 1   MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA 60
           MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA
Sbjct: 1   MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRA 60

Query: 61  VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG 120
           VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG
Sbjct: 61  VLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSG 120

Query: 121 SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY 180
           SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY
Sbjct: 121 SPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGY 180

Query: 181 INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV 240
           INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV
Sbjct: 181 INYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGV 240

Query: 241 VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGL 300
           VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRK                             
Sbjct: 241 VPSPFEHCHVVTTTTHKTLRGCRAGMIFYRK----------------------------- 271

Query: 301 QGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL 360
                     GVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL
Sbjct: 272 ----------GVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLIL 321

Query: 361 VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK 420
           VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK
Sbjct: 322 VDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQK 381

Query: 421 VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL 480
           VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL
Sbjct: 382 VAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGL 441

Query: 481 PDF 483
           PDF
Sbjct: 442 PDF 444


>gi|19923315 serine hydroxymethyltransferase 2 (mitochondrial) [Homo
           sapiens]
          Length = 504

 Score =  614 bits (1584), Expect = e-176
 Identities = 304/460 (66%), Positives = 366/460 (79%), Gaps = 4/460 (0%)

Query: 24  QPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYY 83
           + L DSD E++ ++++E +RQ  GLELIASENF SRA LEALGSCLNNKYSEGYPG+RYY
Sbjct: 47  ESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYY 106

Query: 84  GGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDL 143
           GG E +DE+E LCQ+RAL+A+ LDP  WGVNVQPYSGSPAN AVYTAL++PH RIMGLDL
Sbjct: 107 GGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDL 166

Query: 144 PDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTS 203
           PDGGHLTHG+M+D K+ISATSIFFESMPYK+NP TG I+Y+QL   ARLF P+LIIAGTS
Sbjct: 167 PDGGHLTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTS 226

Query: 204 CYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCR 263
            Y+R ++YAR+R++ DE  A+L+ADMAHISGLVAA V+PSPF+H  +VTTTTHKTLRG R
Sbjct: 227 AYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHKTLRGAR 286

Query: 264 AGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLE 323
           +G+IFYRKGVK+VDPKTG+EI Y  E  IN AVFP LQGGPHNHAIA VAVALKQA T  
Sbjct: 287 SGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPM 346

Query: 324 FKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIA 383
           F+ Y  QV+ N RA+++AL E GY +V+GG+DNHL+LVDLR KG DG RAE+VLE  SI 
Sbjct: 347 FREYSLQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSIT 406

Query: 384 CNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRA 443
            NKNTCPGDRSA+ P GLRLG PALTSR   E DF++V  FI  G+ + L+++S T   A
Sbjct: 407 ANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKSKT---A 463

Query: 444 TLKEFKERLAGDKYQAAVQA-LREEVESFASLFPLPGLPD 482
            L++FK  L  D   +   A LR+ VE FA  FP+PG  +
Sbjct: 464 KLQDFKSFLLKDSETSQRLANLRQRVEQFARAFPMPGFDE 503


>gi|195546900 suppressor of Ty 5 homolog isoform a [Homo sapiens]
          Length = 1087

 Score = 33.1 bits (74), Expect = 0.58
 Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 10/110 (9%)

Query: 5   VNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEA 64
           V+  ++D D W    + +   L+  ++E  NI     +  R G   +  +N       E 
Sbjct: 82  VDDEYEDEDQWEDGAEDI---LEKEEIEASNIDNVVLDEDRSGARRL--QNLWRDQREEE 136

Query: 65  LGSCLNNKYSEGYPGQRYYGGTEFIDEL-ETLCQKRALQAYKLDPQCWGV 113
           LG     KY++   G+  YGG+   DEL + + Q++ L   K DP  W V
Sbjct: 137 LGEYYMKKYAKSSVGETVYGGS---DELSDDITQQQLLPGVK-DPNLWTV 182


>gi|161169023 suppressor of Ty 5 homolog isoform a [Homo sapiens]
          Length = 1087

 Score = 33.1 bits (74), Expect = 0.58
 Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 10/110 (9%)

Query: 5   VNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEA 64
           V+  ++D D W    + +   L+  ++E  NI     +  R G   +  +N       E 
Sbjct: 82  VDDEYEDEDQWEDGAEDI---LEKEEIEASNIDNVVLDEDRSGARRL--QNLWRDQREEE 136

Query: 65  LGSCLNNKYSEGYPGQRYYGGTEFIDEL-ETLCQKRALQAYKLDPQCWGV 113
           LG     KY++   G+  YGG+   DEL + + Q++ L   K DP  W V
Sbjct: 137 LGEYYMKKYAKSSVGETVYGGS---DELSDDITQQQLLPGVK-DPNLWTV 182


>gi|20149524 suppressor of Ty 5 homolog isoform a [Homo sapiens]
          Length = 1087

 Score = 33.1 bits (74), Expect = 0.58
 Identities = 30/110 (27%), Positives = 49/110 (44%), Gaps = 10/110 (9%)

Query: 5   VNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEA 64
           V+  ++D D W    + +   L+  ++E  NI     +  R G   +  +N       E 
Sbjct: 82  VDDEYEDEDQWEDGAEDI---LEKEEIEASNIDNVVLDEDRSGARRL--QNLWRDQREEE 136

Query: 65  LGSCLNNKYSEGYPGQRYYGGTEFIDEL-ETLCQKRALQAYKLDPQCWGV 113
           LG     KY++   G+  YGG+   DEL + + Q++ L   K DP  W V
Sbjct: 137 LGEYYMKKYAKSSVGETVYGGS---DELSDDITQQQLLPGVK-DPNLWTV 182


>gi|27777632 solute carrier family 9, isoform A1 [Homo sapiens]
          Length = 815

 Score = 29.3 bits (64), Expect = 8.3
 Identities = 15/41 (36%), Positives = 27/41 (65%), Gaps = 4/41 (9%)

Query: 223 AYLMADMAHISG---LVAAGVVPSPFEHCHVVTTTTHKTLR 260
           AYL A++ H+SG   L+A+GVV  P+   + ++  +H T++
Sbjct: 341 AYLSAELFHLSGIMALIASGVVMRPYVEAN-ISHKSHTTIK 380


>gi|195546902 suppressor of Ty 5 homolog isoform b [Homo sapiens]
          Length = 1083

 Score = 29.3 bits (64), Expect = 8.3
 Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 10/85 (11%)

Query: 35  NIIKKESNRQRVGLELIAS-----ENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFI 89
           +I++K SN   V L+   S     +N       E LG     KY++   G+  YGG+   
Sbjct: 98  DILEKASNIDNVVLDEDRSGARRLQNLWRDQREEELGEYYMKKYAKSSVGETVYGGS--- 154

Query: 90  DEL-ETLCQKRALQAYKLDPQCWGV 113
           DEL + + Q++ L   K DP  W V
Sbjct: 155 DELSDDITQQQLLPGVK-DPNLWTV 178


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,622,453
Number of Sequences: 37866
Number of extensions: 828650
Number of successful extensions: 1617
Number of sequences better than 10.0: 8
Number of HSP's better than 10.0 without gapping: 3
Number of HSP's successfully gapped in prelim test: 5
Number of HSP's that attempted gapping in prelim test: 1612
Number of HSP's gapped (non-prelim): 9
length of query: 483
length of database: 18,247,518
effective HSP length: 106
effective length of query: 377
effective length of database: 14,233,722
effective search space: 5366113194
effective search space used: 5366113194
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.