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Search of human proteins with 224926830
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
(683 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens] 1386 0.0
gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 1290 0.0
gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 1290 0.0
gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens] 1290 0.0
gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens] 1283 0.0
gi|242247193 SH2B adaptor protein 2 [Homo sapiens] 368 e-101
gi|4885455 SH2B adaptor protein 3 [Homo sapiens] 162 1e-39
gi|194239668 SHC (Src homology 2 domain containing) transforming... 63 1e-09
gi|194239664 SHC (Src homology 2 domain containing) transforming... 63 1e-09
gi|194239662 SHC (Src homology 2 domain containing) transforming... 63 1e-09
gi|32261324 SHC (Src homology 2 domain containing) transforming ... 63 1e-09
gi|187475373 c-src tyrosine kinase [Homo sapiens] 57 4e-08
gi|4758078 c-src tyrosine kinase [Homo sapiens] 57 4e-08
gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo ... 57 6e-08
gi|169790811 SHC (Src homology 2 domain containing) transforming... 57 6e-08
gi|224586793 src homology 2 domain-containing transforming prote... 54 4e-07
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 54 4e-07
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 53 8e-07
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 53 8e-07
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 53 8e-07
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 52 1e-06
gi|222446609 rai-like protein [Homo sapiens] 52 2e-06
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 51 3e-06
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 51 3e-06
gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens] 51 3e-06
gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens] 51 3e-06
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 51 4e-06
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 50 5e-06
gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens] 50 7e-06
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 49 2e-05
>gi|224926830 SH2B adaptor protein 1 isoform 3 [Homo sapiens]
Length = 683
Score = 1386 bits (3587), Expect = 0.0
Identities = 683/683 (100%), Positives = 683/683 (100%)
Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMRG 660
LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMRG
Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMRG 660
Query: 661 CAREMDATPMPPAPSCPSERVTV 683
CAREMDATPMPPAPSCPSERVTV
Sbjct: 661 CAREMDATPMPPAPSCPSERVTV 683
>gi|224926824 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 1290 bits (3337), Expect = 0.0
Identities = 643/673 (95%), Positives = 645/673 (95%), Gaps = 16/673 (2%)
Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMR- 659
LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG R +AGS G
Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG--------------REQAGSHAGVCEG 646
Query: 660 -GCAREMDATPMP 671
GC + T MP
Sbjct: 647 DGCHPDASCTLMP 659
>gi|224926828 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 1290 bits (3337), Expect = 0.0
Identities = 643/673 (95%), Positives = 645/673 (95%), Gaps = 16/673 (2%)
Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMR- 659
LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG R +AGS G
Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG--------------REQAGSHAGVCEG 646
Query: 660 -GCAREMDATPMP 671
GC + T MP
Sbjct: 647 DGCHPDASCTLMP 659
>gi|224926822 SH2B adaptor protein 1 isoform 2 [Homo sapiens]
Length = 671
Score = 1290 bits (3337), Expect = 0.0
Identities = 643/673 (95%), Positives = 645/673 (95%), Gaps = 16/673 (2%)
Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEAGSRLGAMR- 659
LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG R +AGS G
Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQG--------------REQAGSHAGVCEG 646
Query: 660 -GCAREMDATPMP 671
GC + T MP
Sbjct: 647 DGCHPDASCTLMP 659
>gi|224926826 SH2B adaptor protein 1 isoform 1 [Homo sapiens]
Length = 756
Score = 1283 bits (3321), Expect = 0.0
Identities = 637/649 (98%), Positives = 638/649 (98%), Gaps = 1/649 (0%)
Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA
Sbjct: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL
Sbjct: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVL 120
Query: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS
Sbjct: 121 GPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPS 180
Query: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL
Sbjct: 181 SAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGAL 240
Query: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG
Sbjct: 241 KDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGEG 300
Query: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD
Sbjct: 301 GGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVD 360
Query: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS
Sbjct: 361 AQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPS 420
Query: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE
Sbjct: 421 QDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEE 480
Query: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL
Sbjct: 481 GPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQL 540
Query: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM
Sbjct: 541 VLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDM 600
Query: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRS 649
LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ E + S P P S
Sbjct: 601 LEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQ-EPTTSHDPPQPPEPPS 648
>gi|242247193 SH2B adaptor protein 2 [Homo sapiens]
Length = 675
Score = 368 bits (944), Expect = e-101
Identities = 255/626 (40%), Positives = 327/626 (52%), Gaps = 112/626 (17%)
Query: 1 MNGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGA 60
MNGA G + ++P P P P WR+FCE HA+AAA+DFA +F +L +P Y P A
Sbjct: 44 MNGAGP---GPAAAAPVPVPVPVPDWRQFCELHAQAAAVDFAHKFCRFLRDNPAYDTPDA 100
Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDLSLESCRVGG-PLAV 119
A+FSR FA FL F EV R + P + GA +S + E A
Sbjct: 101 GASFSRHFAANFLDVFGEEVRRVL------VAGPTTRGAAVSAEAMEPELADTSALKAAP 154
Query: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
G SRSSED+ S+ ++K +++K FSLR++ V VR + R + +P
Sbjct: 155 YGHSRSSEDV----------STHAATKARVRKGFSLRNMSLCVVDGVRDMWHRRASPEPD 204
Query: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
++A P P ++WT R LRLSR A
Sbjct: 205 AAAAPRTAE-------------------------------PRDKWTRR---LRLSRTLAA 230
Query: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLRSEGE 299
+ +QRE L FM A++AA +G GG QWQKCRLLLR
Sbjct: 231 KVELVD-IQREGALRFMVADDAA----------------AGSGGSAQWQKCRLLLR-RAV 272
Query: 300 GGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMETV 359
RLEFFVPPKASRP++SIP S+I +VRTT LEMP+++NTFV+KVE +EYI+ET+
Sbjct: 273 AEERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETI 332
Query: 360 DAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLP 419
D+ +WV+DIQ C+ PG S L G +R + S EL L + LP
Sbjct: 333 DSLQKHSWVADIQGCVDPGD----SEEDTELSCTRGGCLASRVASCSCEL--LTDAVDLP 386
Query: 420 SQDLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIE 479
P E+ A G A + A H + + L +P+E
Sbjct: 387 R------PPETT------AVG--------------AVVTAPHSRGRDAVRESLI-HVPLE 419
Query: 480 EGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPWFHGMLSRLKAAQ 539
T L +P + TG + +PE E + LS YPWFHG LSR+KAAQ
Sbjct: 420 TFLQT-----LESPGGS-GSDSNNTGEQGAETDPEA-EPELELSDYPWFHGTLSRVKAAQ 472
Query: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
LVL GG +HG+F++RQSETR GEYVLTFNFQGKAKHLRLSLN GQC VQHLWFQS+ D
Sbjct: 473 LVLAGGPRNHGLFVIRQSETRPGEYVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVLD 532
Query: 600 MLEHFRVHPIPLESGGSSDVVLVSYV 625
ML HF HPIPLESGGS+D+ L SYV
Sbjct: 533 MLRHFHTHPIPLESGGSADITLRSYV 558
>gi|4885455 SH2B adaptor protein 3 [Homo sapiens]
Length = 575
Score = 162 bits (409), Expect = 1e-39
Identities = 101/208 (48%), Positives = 118/208 (56%), Gaps = 15/208 (7%)
Query: 487 VHPLSAPYPPLDTPETATGSFLFQGEPEGG-------EGDQPLSGYPWFHGMLSRLKAAQ 539
+H SA P + + L QG GG + D LS YPWFHG +SR+KAAQ
Sbjct: 317 MHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLSCYPWFHGPISRVKAAQ 376
Query: 540 LVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFD 599
LV G +HGVFLVRQSETRRGEYVLTFNFQG AKHLRLSL E GQCRVQHL F S+ D
Sbjct: 377 LVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTERGQCRVQHLHFPSVVD 436
Query: 600 MLEHFRVHPIPLESGGSSDVVLVSYVPSSQRQQGEQSRSAGEEVPVHPRSEA----GSRL 655
ML HF+ PIPLE G + DV L SYV + G + H SE+ GS L
Sbjct: 437 MLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFSLPHWDSESLPHWGSEL 496
Query: 656 G----AMRGCAREMDATPMPPAPSCPSE 679
G + GC R + +P S P +
Sbjct: 497 GLPHLSSSGCPRGLSPEGLPGRSSPPEQ 524
Score = 131 bits (330), Expect = 2e-30
Identities = 127/409 (31%), Positives = 177/409 (43%), Gaps = 91/409 (22%)
Query: 11 ASPSSPPLPPPP--PPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRF 68
+SPSS P P P W EFCE HA AAA + AR++ L+ HPQ+A AE S +F
Sbjct: 9 SSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRAELV-SLQF 67
Query: 69 AELFLQHFEAEV--ARASG------SLSPPILAPLSPGAEISPHDLSLESCRVGGPLAV- 119
+LF ++F EV RA G PP A SP E P GP A
Sbjct: 68 TDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASP--EPGP-----------GPAAPG 114
Query: 120 LGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPP 179
L +RSSE+LA P P S + R S+R I + R + P
Sbjct: 115 LPKARSSEELAPPRPPGPCSF-------------------QHFRRSLRHIFRRRSAGELP 155
Query: 180 SSAGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGA 239
++ T++ P G + + + G +F L+R
Sbjct: 156 AA----HTAAAPGTPGEAAETPARPGLAK------------------KFLPWSLAR---- 189
Query: 240 LKDGAGMVQREELLSFMGAEEAAPDPAGVGRGGGVAGPPSGGGGQPQWQKCRLLLR-SEG 298
+ +E +L + A+EA+ D +WQ+ RL LR + G
Sbjct: 190 --EPPPEALKEAVLRYSLADEASMDSGA------------------RWQRGRLALRRAPG 229
Query: 299 EGGGGSRLEFFVPPKASRPRLSIPCSSITDVRTTTALEMPDRENTFVVKVEGPSEYIMET 358
G LE F PPK+SRP+L CSSI +VR T LEMPD TFV+KV+ ++ I E
Sbjct: 230 PDGPDRVLELFDPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEV 289
Query: 359 VDAQHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSL 407
D Q + +W++++ EC G + + L P TS R +TDSL
Sbjct: 290 GDEQQLNSWMAELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSL 338
>gi|194239668 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 4 [Homo sapiens]
Length = 473
Score = 62.8 bits (151), Expect = 1e-09
Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G
Sbjct: 364 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 418
Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
+ KHL L ++ EG R + F+S+ ++ + + +P+ S GS
Sbjct: 419 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 461
>gi|194239664 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 3 [Homo sapiens]
Length = 584
Score = 62.8 bits (151), Expect = 1e-09
Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G
Sbjct: 475 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 529
Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
+ KHL L ++ EG R + F+S+ ++ + + +P+ S GS
Sbjct: 530 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 572
>gi|194239662 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 1 [Homo sapiens]
Length = 583
Score = 62.8 bits (151), Expect = 1e-09
Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G
Sbjct: 474 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 528
Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
+ KHL L ++ EG R + F+S+ ++ + + +P+ S GS
Sbjct: 529 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 571
>gi|32261324 SHC (Src homology 2 domain containing) transforming
protein 1 isoform 2 [Homo sapiens]
Length = 474
Score = 62.8 bits (151), Expect = 1e-09
Identities = 39/104 (37%), Positives = 57/104 (54%), Gaps = 6/104 (5%)
Query: 513 PEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
P+ + L G PWFHG LSR +A L+ G FLVR+S T G+YVLT G
Sbjct: 365 PQSVSMAEQLRGEPWFHGKLSRREAEALLQLNGD-----FLVRESTTTPGQYVLTGLQSG 419
Query: 573 KAKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
+ KHL L ++ EG R + F+S+ ++ + + +P+ S GS
Sbjct: 420 QPKHL-LLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGS 462
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 57.4 bits (137), Expect = 4e-08
Identities = 29/91 (31%), Positives = 51/91 (56%), Gaps = 3/91 (3%)
Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573
EG + LS PWFHG ++R +A +L+ TG +FLVR+S G+Y L + GK
Sbjct: 69 EGVKAGTKLSLMPWFHGKITREQAERLLYPPETG---LFLVRESTNYPGDYTLCVSCDGK 125
Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHF 604
+H R+ + + ++F+++ ++EH+
Sbjct: 126 VEHYRIMYHASKLSIDEEVYFENLMQLVEHY 156
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 57.4 bits (137), Expect = 4e-08
Identities = 29/91 (31%), Positives = 51/91 (56%), Gaps = 3/91 (3%)
Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573
EG + LS PWFHG ++R +A +L+ TG +FLVR+S G+Y L + GK
Sbjct: 69 EGVKAGTKLSLMPWFHGKITREQAERLLYPPETG---LFLVRESTNYPGDYTLCVSCDGK 125
Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHF 604
+H R+ + + ++F+++ ++EH+
Sbjct: 126 VEHYRIMYHASKLSIDEEVYFENLMQLVEHY 156
>gi|239751592 PREDICTED: hypothetical protein XP_002347924 [Homo
sapiens]
Length = 475
Score = 57.0 bits (136), Expect = 6e-08
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 519 DQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLR 578
++ L PW+HG +SR A +++ G FLVR S T G+YVLT G+ KHL
Sbjct: 372 EEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQPKHL- 425
Query: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
L ++ EG R + + F+SI +++H + P+ + S
Sbjct: 426 LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES 463
>gi|169790811 SHC (Src homology 2 domain containing) transforming
protein 2 [Homo sapiens]
Length = 582
Score = 57.0 bits (136), Expect = 6e-08
Identities = 34/98 (34%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 519 DQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLR 578
++ L PW+HG +SR A +++ G FLVR S T G+YVLT G+ KHL
Sbjct: 479 EEQLRQEPWYHGRMSRRAAERMLRADGD-----FLVRDSVTNPGQYVLTGMHAGQPKHL- 532
Query: 579 LSLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
L ++ EG R + + F+SI +++H + P+ + S
Sbjct: 533 LLVDPEGVVRTKDVLFESISHLIDHHLQNGQPIVAAES 570
>gi|224586793 src homology 2 domain-containing transforming protein
C3 [Homo sapiens]
Length = 594
Score = 54.3 bits (129), Expect = 4e-07
Identities = 35/97 (36%), Positives = 50/97 (51%), Gaps = 6/97 (6%)
Query: 520 QPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRL 579
+ L W+ G +SR +A L+ G FLVR+S T G +VLT G+AKHL L
Sbjct: 492 EELQAETWYQGEMSRKEAEGLLEKDGD-----FLVRKSTTNPGSFVLTGMHNGQAKHL-L 545
Query: 580 SLNEEGQCRVQHLWFQSIFDMLEHFRVHPIPLESGGS 616
++ EG R + F SI ++ H +P+ S GS
Sbjct: 546 LVDPEGTIRTKDRVFDSISHLINHHLESSLPIVSAGS 582
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 54.3 bits (129), Expect = 4e-07
Identities = 39/138 (28%), Positives = 66/138 (47%), Gaps = 18/138 (13%)
Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585
PWFHG +SR ++ Q+VL G+ ++G FL+R + G Y L +GK H R+ ++ G
Sbjct: 167 PWFHGKISREESEQIVLI-GSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTG 224
Query: 586 QCRV-QHLWFQSIFDMLEHF--------RVHPIPLESGGSSDVV-------LVSYVPSSQ 629
+ + + F +++ ++EH+ RV +P + G+ V L P+S
Sbjct: 225 KLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASS 284
Query: 630 RQQGEQSRSAGEEVPVHP 647
QG + S P P
Sbjct: 285 PAQGNRQESTVSFNPYEP 302
Score = 33.1 bits (74), Expect = 0.87
Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585
P+F G ++R +A ++ GG S G++L+RQS G + L+ KA H + G
Sbjct: 14 PFFFGNITREEAEDYLVQGGM-SDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 53.1 bits (126), Expect = 8e-07
Identities = 33/94 (35%), Positives = 51/94 (54%), Gaps = 5/94 (5%)
Query: 512 EPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ 571
E E D LS PWFHG +S +A Q + G+FLVR+S G+YVL +F
Sbjct: 66 EREALSADPKLSLMPWFHGKISGQEAVQQLQPP---EDGLFLVRESARHPGDYVLCVSFG 122
Query: 572 GKAKHLRLSLNEEGQCRV-QHLWFQSIFDMLEHF 604
H R+ L+ +G + + ++F ++ DM+EH+
Sbjct: 123 RDVIHYRV-LHRDGHLTIDEAVFFCNLMDMVEHY 155
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 53.1 bits (126), Expect = 8e-07
Identities = 33/94 (35%), Positives = 51/94 (54%), Gaps = 5/94 (5%)
Query: 512 EPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ 571
E E D LS PWFHG +S +A Q + G+FLVR+S G+YVL +F
Sbjct: 108 EREALSADPKLSLMPWFHGKISGQEAVQQLQPP---EDGLFLVRESARHPGDYVLCVSFG 164
Query: 572 GKAKHLRLSLNEEGQCRV-QHLWFQSIFDMLEHF 604
H R+ L+ +G + + ++F ++ DM+EH+
Sbjct: 165 RDVIHYRV-LHRDGHLTIDEAVFFCNLMDMVEHY 197
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 53.1 bits (126), Expect = 8e-07
Identities = 33/94 (35%), Positives = 51/94 (54%), Gaps = 5/94 (5%)
Query: 512 EPEGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ 571
E E D LS PWFHG +S +A Q + G+FLVR+S G+YVL +F
Sbjct: 107 EREALSADPKLSLMPWFHGKISGQEAVQQLQPP---EDGLFLVRESARHPGDYVLCVSFG 163
Query: 572 GKAKHLRLSLNEEGQCRV-QHLWFQSIFDMLEHF 604
H R+ L+ +G + + ++F ++ DM+EH+
Sbjct: 164 RDVIHYRV-LHRDGHLTIDEAVFFCNLMDMVEHY 196
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 52.4 bits (124), Expect = 1e-06
Identities = 27/87 (31%), Positives = 49/87 (56%), Gaps = 3/87 (3%)
Query: 523 SGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLN 582
+G PW++G ++R +A + G G FL+R SE+ ++ ++ QGK KH ++ L
Sbjct: 278 AGNPWYYGKVTRHQAEMAL--NERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLK 335
Query: 583 EEGQCRVQHLWFQSIFDMLEHFRVHPI 609
E C Q F ++ +++EH++ PI
Sbjct: 336 ETVYCIGQRK-FSTMEELVEHYKKAPI 361
>gi|222446609 rai-like protein [Homo sapiens]
Length = 630
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/135 (30%), Positives = 64/135 (47%), Gaps = 12/135 (8%)
Query: 486 TVHPLSAPYPPLDTPETATGSFLFQGEPEGGEGDQPLSGYPW----FHGMLSRLKAAQLV 541
+ PL +P+ PET Q P + W +HG LSR A L+
Sbjct: 483 SAQPLGSPWHCGKAPETVQPGATAQ--PASSHSLPHIKQQLWSEECYHGKLSRKAAESLL 540
Query: 542 LTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQCRVQHLWFQSIFDML 601
+ G FLVR+S T G+YVL+ G+AKHL L ++ EG+ R + F ++ ++
Sbjct: 541 VKDGD-----FLVRESATSPGQYVLSGLQGGQAKHL-LLVDPEGKVRTKDHVFDNVGHLI 594
Query: 602 EHFRVHPIPLESGGS 616
+ + +P+ S GS
Sbjct: 595 RYHMDNSLPIISSGS 609
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 51.2 bits (121), Expect = 3e-06
Identities = 26/80 (32%), Positives = 48/80 (60%), Gaps = 3/80 (3%)
Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585
PWFHG +SR ++ Q+VL G+ ++G FL+R + G Y L +GK H R+ ++ G
Sbjct: 167 PWFHGKISREESEQIVLI-GSKTNGKFLIR-ARDNNGSYALCLLHEGKVLHYRIDKDKTG 224
Query: 586 QCRV-QHLWFQSIFDMLEHF 604
+ + + F +++ ++EH+
Sbjct: 225 KLSIPEGKKFDTLWQLVEHY 244
Score = 33.1 bits (74), Expect = 0.87
Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 1/60 (1%)
Query: 526 PWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEG 585
P+F G ++R +A ++ GG S G++L+RQS G + L+ KA H + G
Sbjct: 14 PFFFGNITREEAEDYLVQGGM-SDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 51.2 bits (121), Expect = 3e-06
Identities = 60/229 (26%), Positives = 88/229 (38%), Gaps = 24/229 (10%)
Query: 310 VPPKASRPRLSIPCS--SITDVRTTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAW 367
VP + P L P S +++ ++ TT+L P + T P + +
Sbjct: 391 VPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPAST 450
Query: 368 VSDIQECLSPGPCPATSPRPMTLP--LAPGTSFLTRENTDSLELSCLNHSESLPSQDLLL 425
D +P PA+ P +L ++P +S LT +L S +HS P L++
Sbjct: 451 PPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALS-SLASHSPQAPLSSLIM 509
Query: 426 GPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSM-ELLPPEL-----PPRIPIE 479
P E+ L+ PS P AS+ +++ L PP L P P
Sbjct: 510 PPLETQSSLAP---------PSLQTPP--ASLTTPPLENLPSLAPPPLQTASAPLTTPHL 558
Query: 480 EGPPTGTVHPLSAPYPPLDTPETATGSFLFQGEPEG--GEGDQPLSGYP 526
E PP PL AP PL TP T S + P+ PL G P
Sbjct: 559 ETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLP 607
Score = 41.2 bits (95), Expect = 0.003
Identities = 107/452 (23%), Positives = 152/452 (33%), Gaps = 89/452 (19%)
Query: 81 ARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSS 140
AR + +P +L P PG+ P ++ + RV G +G +E G + +
Sbjct: 14 ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG-----IGGA 68
Query: 141 STTSSKPKLKKRFSLRSVGRSVRG-SVRGILQWRGTVDPPSSAGPLETSSGPPVLGGN-S 198
+ S P+ RS G S R + R RG PP+ TS GP G S
Sbjct: 69 TIPESAPRAG---PTRSAGTSSRNPASRPPASGRGERAPPAK----NTSPGPVSSPGRAS 121
Query: 199 NSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAG---------MVQR 249
+ G G G + ++ T + T +R LS GA +D +G M +R
Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALS--AGARRDTSGPTPGTPSPAMARR 179
Query: 250 EELLSFMGAEEAAPDPAGVGRGGGVAGPPSGG-------GGQPQWQKCRLLLRSEGEGGG 302
G E P PA R PP+ G + + R GG
Sbjct: 180 SRA---AGTEVGLPRPAPSAR----PRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG 232
Query: 303 GSRLEFFVPPKASRPRLSIPCSSITDVR-TTTALEMPDRENTFVVKVEGPSEYIMETVDA 361
G + +S LS P S R T A P + P ++ +
Sbjct: 233 GLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQ----------PKPKGLQALRP 282
Query: 362 QHVKAWVSDIQECLSPGPCPATSPRPMTLPLAPGTSFLTRENTDSLELSCLNHSESLPSQ 421
V D L P S P+ P GT D N + LP+
Sbjct: 283 PQVTPPRKDAAPALGP-----LSSSPLATPSPSGTKARPVPPPD-------NAATPLPA- 329
Query: 422 DLLLGPSESNDRLSQGAYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEEG 481
L PS + P A SPS+ S++ LP PP P +
Sbjct: 330 --TLPPSPPL----------ATPLPLAPPSPSAP-------PSLQTLPS--PPATPPSQA 368
Query: 482 PPTGTVHPLSAP-----YPPLDTPETATGSFL 508
PP+ T P+ AP PP+ P + T L
Sbjct: 369 PPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSL 400
Score = 37.0 bits (84), Expect = 0.060
Identities = 79/297 (26%), Positives = 103/297 (34%), Gaps = 56/297 (18%)
Query: 4 APSPEDGASPSSPPLPPPP--PPSWR----EFCESHARAAALDFARRFRLYLASHPQYAG 57
AP + P SP PPP PP + S + L RR P G
Sbjct: 811 APFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRR--------PPTPG 862
Query: 58 PGAEAAFSRRFAELFLQHFEAEVARASGSLSPPILAPLSPGAEISPHDL-SLESCRVGGP 116
P + R L S +LS P LA S A +P +L +S GG
Sbjct: 863 PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGA 922
Query: 117 LAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTV 176
A P +LA P++ S P L + RG+ L W
Sbjct: 923 AASPPPDA---ELAACHPAAWSRGPA----PPL-----------AFRGAPGAPLPWPPAT 964
Query: 177 DPPSS---------AGPLETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHR 227
P S+ GP + P L + +SGG G G + SP + R
Sbjct: 965 GPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQA---R 1021
Query: 228 FERLRLSRGGGALKDGAGMVQREELLS---FMGAEEAAPDPAGVGRGGGVAGPPSGG 281
L L GAL+ A +VQ LLS + A E A +G G GG G +GG
Sbjct: 1022 LGELPL----GALQ--ASVVQ--HLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 1070
Score = 30.8 bits (68), Expect = 4.3
Identities = 56/210 (26%), Positives = 77/210 (36%), Gaps = 29/210 (13%)
Query: 2 NGAPSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAE 61
+ P P+ ++PPL PP P S + + R LA+ P P
Sbjct: 719 SATPPPQAPPPLAAPPLQVPPSPP-----ASPPMSPSATPPPRVPPLLAAPPLQVPPSPP 773
Query: 62 AAFSRRFAELFLQHFEAEVARASGSL----SPPIL----APLSPGAEISPHDLSLESCRV 113
A+ + L +A A A+ L SPP AP SP A +
Sbjct: 774 ASLP--MSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPM---------- 821
Query: 114 GGPLAVLGPSRSSEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWR 173
PLA P ++ LA PL V S S + +R SV G R L
Sbjct: 822 -SPLAT-PPPQAPPVLAAPL-LQVPPSPPASPTLQAPRRPPTPGPDTSVSGP-RLTLALA 877
Query: 174 GTVDPPSSAGPLETSSGPPVLGGNSNSNSS 203
PP S P T SGP + G +S++ S+
Sbjct: 878 PGPPPPPSRSPSSTLSGPDLAGHSSSATST 907
>gi|4506431 RAS p21 protein activator 1 isoform 1 [Homo sapiens]
Length = 1047
Score = 51.2 bits (121), Expect = 3e-06
Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 2/96 (2%)
Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573
E G + P G WFHG +S+ +A L++T G FLVR S+ G+Y L F
Sbjct: 338 EVGREEDPHEGKIWFHGKISKQEAYNLLMT--VGQVCSFLVRPSDNTPGDYSLYFRTNEN 395
Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPI 609
+ ++ Q + ++ SI D+++H+R I
Sbjct: 396 IQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQI 431
Score = 43.5 bits (101), Expect = 6e-04
Identities = 50/181 (27%), Positives = 79/181 (43%), Gaps = 16/181 (8%)
Query: 437 GAYGGLS---DRPSASISPSSASIAASHF--DSMELLPPELPPRIPIEEGPPTGTVHPLS 491
GA GG +A ++ ++A +A + S ++ +LP + E P G PL
Sbjct: 79 GALGGAGLTGGGTAAGVAGAAAGVAGAAVAGPSGDMALTKLPTSLLAETLGPGGGFPPLP 138
Query: 492 AP--YPPLDTP--ETATGSFLFQGEPEGGEGDQPLSGYP---WFHGMLSRLKAAQLVLTG 544
P PPL G L E E E PL+ P W+HG L R A + +
Sbjct: 139 PPPYLPPLGAGLGTVDEGDSLDGPEYEEEEVAIPLTAPPTNQWYHGKLDRTIAEERLRQA 198
Query: 545 GTGSHGVFLVRQSETRRGEYVLTFNFQ-GKAKHLRLSLNEEGQCRVQHLWFQSIFDMLEH 603
G G +L+R+S+ R G +VL+F Q H R+ + G + F S+ D++ +
Sbjct: 199 GKS--GSYLIRESDRRPGSFVLSFLSQMNVVNHFRI-IAMCGDYYIGGRRFSSLSDLIGY 255
Query: 604 F 604
+
Sbjct: 256 Y 256
>gi|12545406 RAS p21 protein activator 1 isoform 2 [Homo sapiens]
Length = 870
Score = 51.2 bits (121), Expect = 3e-06
Identities = 29/96 (30%), Positives = 47/96 (48%), Gaps = 2/96 (2%)
Query: 514 EGGEGDQPLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGK 573
E G + P G WFHG +S+ +A L++T G FLVR S+ G+Y L F
Sbjct: 161 EVGREEDPHEGKIWFHGKISKQEAYNLLMT--VGQVCSFLVRPSDNTPGDYSLYFRTNEN 218
Query: 574 AKHLRLSLNEEGQCRVQHLWFQSIFDMLEHFRVHPI 609
+ ++ Q + ++ SI D+++H+R I
Sbjct: 219 IQRFKICPTPNNQFMMGGRYYNSIGDIIDHYRKEQI 254
Score = 35.4 bits (80), Expect = 0.18
Identities = 23/79 (29%), Positives = 40/79 (50%), Gaps = 4/79 (5%)
Query: 527 WFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQ-GKAKHLRLSLNEEG 585
W+HG L R A + + G G +L+R+S+ R G +VL+F Q H R+ + G
Sbjct: 4 WYHGKLDRTIAEERLRQAGKS--GSYLIRESDRRPGSFVLSFLSQMNVVNHFRI-IAMCG 60
Query: 586 QCRVQHLWFQSIFDMLEHF 604
+ F S+ D++ ++
Sbjct: 61 DYYIGGRRFSSLSDLIGYY 79
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 50.8 bits (120), Expect = 4e-06
Identities = 108/449 (24%), Positives = 159/449 (35%), Gaps = 45/449 (10%)
Query: 81 ARASGSLSPPILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSRSSEDLAGPLPSSVSSS 140
AR + +P +L P PG+ P ++ + RV G +G +E G + +
Sbjct: 14 ARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG-----IGGA 68
Query: 141 STTSSKPKLKKRFSLRSVGRSVRGSV-RGILQWRGTVDPPSSAGPLETSSGPPVLGGN-S 198
+ S P+ RS G S R R RG PP+ TS GP G S
Sbjct: 69 TIPESAPRAGPT---RSAGTSSRNPASRPPASGRGERAPPAK----NTSPGPVSSPGRAS 121
Query: 199 NSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAGMVQREELLSFMGA 258
+ G G G + ++ T + T +R LS GA +D +G +
Sbjct: 122 GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALS--AGARRDTSGPTPGTPSPAMARR 179
Query: 259 EEAAPDPAGVGRGGGVAGP--PSGG-------GGQPQWQKCRLLLRSEGEGGGGSRLEFF 309
AA G+ R A P P+ G + + R GGG +
Sbjct: 180 SRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS 239
Query: 310 VPPKASRPRLSIPCSSITDVR-TTTALEMPDRENTFVVKVEGPSEYIMETVDAQHVKAWV 368
+S LS P S R T A P + ++ P + DA +
Sbjct: 240 RSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 299
Query: 369 SDIQECLSPGPCPAT-SPRPMTLPLAPGTSFLTRENTDSLELSCLNHS-----ESLPSQD 422
S +P P A S P TLP P +S LT + L L+ + S ++LPS
Sbjct: 300 SS-SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPP 358
Query: 423 LLLGPSESNDRLS----QGAYGGLSDRPSASIS-------PSSASIAASHFDSMELLPPE 471
PS++ L Q + L P + ++ P+ A S PP
Sbjct: 359 AT-PPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPL 417
Query: 472 LPPRIPIEEGPPTGTVHPLSAPYPPLDTP 500
P P + P VH L AP+ P +P
Sbjct: 418 SPLATPSPQAPNALAVHLLQAPFSPPPSP 446
Score = 37.7 bits (86), Expect = 0.035
Identities = 87/339 (25%), Positives = 117/339 (34%), Gaps = 82/339 (24%)
Query: 4 APSPEDGASPSSPPLPPPPPPSWREFCESHARAAALDFAR---RFRLYLASHPQYAGPGA 60
+P SPS+ P P PPP A L A+ + LA+ P A P
Sbjct: 484 SPPASPPMSPSATPPPQAPPP---------LAAPPLQLAKPPPQAPPALATPPLQALPSP 534
Query: 61 EAAFSRRFAELFLQHFEAEVARASGSLSPPILA-PLSPGAEISPHDLSLESCR------- 112
A+F + +PP+LA PL P +L++ R
Sbjct: 535 PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGP 594
Query: 113 ---VGGPLAVLG--------PSRS-SEDLAGPLPSSVSSSSTTSSKPKLKKRFSLRSVGR 160
V GP L PSRS S L+GP + SSS TS+ +L+ S G
Sbjct: 595 DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP-DLAGHSSSATSTPEELRGYDSGPEGGA 653
Query: 161 SV--------------------------RGSVRGILQWRGTVDPPSS---------AGPL 185
+ RG+ L W P S+ GP
Sbjct: 654 AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPE 713
Query: 186 ETSSGPPVLGGNSNSNSSGGAGTVGRGLVSDGTSPGERWTHRFERLRLSRGGGALKDGAG 245
+ P L + +SGG G G + SP + R L L GAL+ A
Sbjct: 714 SATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQA---RLGELPL----GALQ--AS 764
Query: 246 MVQREELLS---FMGAEEAAPDPAGVGRGGGVAGPPSGG 281
+VQ LLS + A E A +G G GG G +GG
Sbjct: 765 VVQ--HLLSRTLLLAAAEGAAGGSGGGPGGAEGGGVTGG 801
Score = 30.8 bits (68), Expect = 4.3
Identities = 51/194 (26%), Positives = 66/194 (34%), Gaps = 40/194 (20%)
Query: 13 PSSPPLPPPPPPSWREFCESHARAAALDFARRFRLYLASHPQYAGPGAEAAFSRRFAELF 72
P SPP PP PS ++ AA L LA P A P A
Sbjct: 482 PPSPPASPPMSPSATPPPQAPPPLAAPP------LQLAKPPPQAPPA--------LATPP 527
Query: 73 LQHFEAEVARASGS--LSPPILAPLSPGAEISPHDLSLESCRVGGPLAVLGPSR-SSEDL 129
LQ + A G SP P+SP A P + + PL + PS +S L
Sbjct: 528 LQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPV----LAAPLLQVPPSPPASPTL 583
Query: 130 AGPLPSSVSSSSTTSSKPKLKKRFSLRSVGRSVRGSVRGILQWRGTVDPPSSAGPLETSS 189
P T+ S P+L L PP S P T S
Sbjct: 584 QAPRRPPTPGPDTSVSGPRLT-------------------LALAPGPPPPPSRSPSSTLS 624
Query: 190 GPPVLGGNSNSNSS 203
GP + G +S++ S+
Sbjct: 625 GPDLAGHSSSATST 638
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 50.4 bits (119), Expect = 5e-06
Identities = 31/92 (33%), Positives = 48/92 (52%), Gaps = 12/92 (13%)
Query: 524 GYPWFHGMLSRLKAAQLVL------TGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHL 577
G WFH + + +A+ +L TGG G FLVR+SET +Y L+F G+ +H
Sbjct: 529 GEKWFHKKVEKRTSAEKLLQEYCMETGG--KDGTFLVRESETFPNDYTLSFWRSGRVQHC 586
Query: 578 RLSLNEEG----QCRVQHLWFQSIFDMLEHFR 605
R+ EG +L F SI+ +++H+R
Sbjct: 587 RIRSTMEGGTLKYYLTDNLTFSSIYALIQHYR 618
Score = 43.1 bits (100), Expect = 8e-04
Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 3/89 (3%)
Query: 521 PLSGYPWFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLS 580
P PW++ LSR +A +++ G FL+R+ E Y +TF +GK KH R++
Sbjct: 640 PHESKPWYYDSLSRGEAEDMLMR--IPRDGAFLIRKREGS-DSYAITFRARGKVKHCRIN 696
Query: 581 LNEEGQCRVQHLWFQSIFDMLEHFRVHPI 609
+ +F+S+ +++ ++ H +
Sbjct: 697 RDGRHFVLGTSAYFESLVELVSYYEKHSL 725
>gi|41281821 SH2 domain containing 3C isoform a [Homo sapiens]
Length = 860
Score = 50.1 bits (118), Expect = 7e-06
Identities = 54/242 (22%), Positives = 91/242 (37%), Gaps = 32/242 (13%)
Query: 438 AYGGLSDRPSASISPSSASIAASHFDSMELLPPELPPRIPIEEGPPTGTVHPLSAPYPPL 497
A G L D P+ +PS+ + + PE+P EE PP +A P
Sbjct: 127 ATGPLEDTPAMEPNPSAVEVDP-------IRKPEVPTGDVEEERPPRDVHSERAAGEPEA 179
Query: 498 --DTPETATGSFLFQGEPEGGEGD---------QPLSGYPWFHGMLSRLKAAQLVLTGGT 546
D + + ++ PE + L + W+HG + R + LV G
Sbjct: 180 GSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGD 239
Query: 547 GSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLS----LNEEGQCRVQHLWFQSIFDMLE 602
FL+R S T G+YVLT ++ +A H +++ E +Q+L+ Q FD +
Sbjct: 240 -----FLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVP 294
Query: 603 HFRVHPIPLESGGSSDVVLVSYVPSSQR-----QQGEQSRSAGEEVPVHPRSEAGSRLGA 657
+ + S + Y P ++ + G P P S +G +
Sbjct: 295 ALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSH 354
Query: 658 MR 659
M+
Sbjct: 355 MK 356
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 48.9 bits (115), Expect = 2e-05
Identities = 32/101 (31%), Positives = 48/101 (47%), Gaps = 16/101 (15%)
Query: 523 SGYPWFHGMLS----------RLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQG 572
S WFHG L RL + TG G FLVR+SET G+Y L+F G
Sbjct: 546 SNEKWFHGKLGAGRDGRHIAERLLTEYCIETGAPD--GSFLVRESETFVGDYTLSFWRNG 603
Query: 573 KAKHLRLSLNEEGQC----RVQHLWFQSIFDMLEHFRVHPI 609
K +H R+ ++ +L F S++D++ H++ P+
Sbjct: 604 KVQHCRIHSRQDAGTPKFFLTDNLVFDSLYDLITHYQQVPL 644
Score = 44.7 bits (104), Expect = 3e-04
Identities = 25/84 (29%), Positives = 45/84 (53%), Gaps = 6/84 (7%)
Query: 527 WFHGMLSRLKAAQLVLTGGTGSHGVFLVRQSETRRGEYVLTFNFQGKAKHLRLSLNEEGQ 586
W+H L+R +A +++ G FLVR+ Y ++F +GK KH R + +EGQ
Sbjct: 668 WYHASLTRAQAEHMLMR--VPRDGAFLVRK-RNEPNSYAISFRAEGKIKHCR--VQQEGQ 722
Query: 587 -CRVQHLWFQSIFDMLEHFRVHPI 609
+ + F S+ D++ ++ HP+
Sbjct: 723 TVMLGNSEFDSLVDLISYYEKHPL 746
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,247,550
Number of Sequences: 37866
Number of extensions: 2156087
Number of successful extensions: 19574
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 187
Number of HSP's successfully gapped in prelim test: 442
Number of HSP's that attempted gapping in prelim test: 15697
Number of HSP's gapped (non-prelim): 3865
length of query: 683
length of database: 18,247,518
effective HSP length: 109
effective length of query: 574
effective length of database: 14,120,124
effective search space: 8104951176
effective search space used: 8104951176
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.