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Search of human proteins with 224586929
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|224586929 protein tyrosine phosphatase, non-receptor type 22
(lymphoid) isoform 1 [Homo sapiens]
(807 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|224586929 protein tyrosine phosphatase, non-receptor type 22 ... 1634 0.0
gi|224586931 protein tyrosine phosphatase, non-receptor type 22 ... 1380 0.0
gi|196114951 protein tyrosine phosphatase, non-receptor type 12 ... 425 e-119
gi|18375655 protein tyrosine phosphatase, non-receptor type 18 i... 283 4e-76
gi|196114967 protein tyrosine phosphatase, non-receptor type 12 ... 275 9e-74
gi|196114970 protein tyrosine phosphatase, non-receptor type 12 ... 256 6e-68
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 194 2e-49
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 194 2e-49
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 194 2e-49
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 193 5e-49
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 193 5e-49
gi|148728162 protein tyrosine phosphatase, receptor type, J isof... 193 6e-49
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 190 4e-48
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 187 3e-47
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 187 3e-47
gi|18104989 protein tyrosine phosphatase, non-receptor type 6 is... 184 3e-46
gi|18104991 protein tyrosine phosphatase, non-receptor type 6 is... 184 3e-46
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 184 4e-46
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 184 4e-46
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 184 4e-46
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 184 4e-46
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 184 4e-46
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 184 4e-46
gi|18104993 protein tyrosine phosphatase, non-receptor type 6 is... 184 4e-46
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 181 2e-45
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 181 2e-45
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 181 3e-45
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 180 5e-45
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 180 5e-45
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 180 5e-45
>gi|224586929 protein tyrosine phosphatase, non-receptor type 22
(lymphoid) isoform 1 [Homo sapiens]
Length = 807
Score = 1634 bits (4230), Expect = 0.0
Identities = 807/807 (100%), Positives = 807/807 (100%)
Query: 1 MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRY 60
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRY
Sbjct: 1 MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRY 60
Query: 61 KDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY 120
KDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY
Sbjct: 61 KDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY 120
Query: 121 SVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS 180
SVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS
Sbjct: 121 SVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS 180
Query: 181 ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI 240
ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI
Sbjct: 181 ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI 240
Query: 241 DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK 300
DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK
Sbjct: 241 DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK 300
Query: 301 HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE 360
HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE
Sbjct: 301 HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE 360
Query: 361 ISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSL 420
ISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSL
Sbjct: 361 ISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSL 420
Query: 421 LFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSC 480
LFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSC
Sbjct: 421 LFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSC 480
Query: 481 FVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSW 540
FVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSW
Sbjct: 481 FVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSW 540
Query: 541 PPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQES 600
PPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQES
Sbjct: 541 PPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQES 600
Query: 601 AVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTS 660
AVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTS
Sbjct: 601 AVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTS 660
Query: 661 EPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIET 720
EPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIET
Sbjct: 661 EPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIET 720
Query: 721 YSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNS 780
YSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNS
Sbjct: 721 YSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNS 780
Query: 781 SSFLNFGFANRFSKPKGPRNPPPTWNI 807
SSFLNFGFANRFSKPKGPRNPPPTWNI
Sbjct: 781 SSFLNFGFANRFSKPKGPRNPPPTWNI 807
>gi|224586931 protein tyrosine phosphatase, non-receptor type 22
(lymphoid) isoform 2 [Homo sapiens]
Length = 691
Score = 1380 bits (3573), Expect = 0.0
Identities = 684/684 (100%), Positives = 684/684 (100%)
Query: 1 MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRY 60
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRY
Sbjct: 1 MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRY 60
Query: 61 KDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY 120
KDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY
Sbjct: 61 KDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY 120
Query: 121 SVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS 180
SVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS
Sbjct: 121 SVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS 180
Query: 181 ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI 240
ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI
Sbjct: 181 ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI 240
Query: 241 DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK 300
DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK
Sbjct: 241 DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDK 300
Query: 301 HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE 360
HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE
Sbjct: 301 HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE 360
Query: 361 ISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSL 420
ISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSL
Sbjct: 361 ISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSL 420
Query: 421 LFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSC 480
LFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSC
Sbjct: 421 LFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSC 480
Query: 481 FVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSW 540
FVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSW
Sbjct: 481 FVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSW 540
Query: 541 PPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQES 600
PPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQES
Sbjct: 541 PPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQES 600
Query: 601 AVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTS 660
AVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTS
Sbjct: 601 AVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTS 660
Query: 661 EPKKFDDSVILRPSKSVKLRSPKS 684
EPKKFDDSVILRPSKSVKLRSPKS
Sbjct: 661 EPKKFDDSVILRPSKSVKLRSPKS 684
>gi|196114951 protein tyrosine phosphatase, non-receptor type 12
isoform 1 [Homo sapiens]
Length = 780
Score = 425 bits (1093), Expect = e-119
Identities = 277/718 (38%), Positives = 383/718 (53%), Gaps = 116/718 (16%)
Query: 1 MDQREILQKFLDEAQSKKIT----KEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIK 56
M+Q EIL+KF+ Q+ K ++ FA +F++L+R STKY+ +K YPT EK +N+K
Sbjct: 1 MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVK 60
Query: 57 KNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRM 116
KNRYKDILP+D+SRV+L+L T +DS YINANFIKGVYGPKAY+ATQGPL+ T++DFWRM
Sbjct: 61 KNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRM 120
Query: 117 IWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKV 176
IWEY+V+IIVMAC E+EMG+KKCERYW GE + F PF +SCE E+ ++DY IRTL +
Sbjct: 121 IWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLL 180
Query: 177 KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGV 236
+F +E+R +YQFHY NWPDHDVPSS D IL++I +R YQE + VPICIHCSAGCGRTG
Sbjct: 181 EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGA 240
Query: 237 ICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDV 296
ICAIDYTW LLK G IPE F+VF+LI+EMRTQR S VQT+EQYELV+ A+ +LF++Q+ +
Sbjct: 241 ICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQL 300
Query: 297 --------IRD--KHSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKM 346
I D TE+ PEK DS P P++ + + + K
Sbjct: 301 YEIHGAQKIADGVNEINTENMVSSIEPEKQ-----DSPPPKPPRTRS----CLVEGDAKE 351
Query: 347 EIKE---------------SSSFDFRTSEISAKEEL----VLHPAKSSTSFDFLELNYS- 386
EI + S+F T+ + VLH S L NYS
Sbjct: 352 EILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSK 411
Query: 387 --------------FDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEG-------- 424
DK + + ++ K P+ P +S D +LL G
Sbjct: 412 STELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGP----KSFDGNTLLNRGHAIKIKSA 467
Query: 425 --C---SNSKP------VNAAGRYFNSKVPITRTKS-----TPFELIQQRETK------E 462
C SKP +N NS V + T+S TP E Q +T
Sbjct: 468 SPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLP 527
Query: 463 VDSKENFSYLESQPHDSCFVEMQAQKVMHVSSAELNY------SLPYDSKHQIRNASNVK 516
+D K + ++ P ++ + + +S+++NY SL Q+ V
Sbjct: 528 LDEKGHVTWSFHGPENA----IPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVD 583
Query: 517 HHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFS 576
H ++S PL P + P S DG V + +++++ S
Sbjct: 584 HDNTS--------PLFRTPLSFTNPLHSDDSDSD---ERNSDGAVTQNKTNISTASATVS 632
Query: 577 YYNSHDSLSLNSPTNISSLLNQESAVLATAPR----IDDEIPPPLPVRTPESFIVVEE 630
S +S+S +S + + + + ++ PPPLP RTPESF++ E
Sbjct: 633 AATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASE 690
Score = 59.3 bits (142), Expect = 1e-08
Identities = 38/116 (32%), Positives = 53/116 (45%), Gaps = 14/116 (12%)
Query: 694 PPPLPERTLESFFLADEDCMQAQSIETYSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLK 753
PPPLPERT ESF LA E ++T S +++ + + S++ K
Sbjct: 674 PPPLPERTPESFVLASE----------HNTPVRSEWSELQSQERSEQKKSEGLITSENEK 723
Query: 754 I---LRNMKKSICNSCPPNKPAESVQ-SNNSSSFLNFGFANRFSKPKGPRNPPPTW 805
+ +C CPP + Q S N + + GF NR KPKGPR+PP W
Sbjct: 724 CDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEW 779
>gi|18375655 protein tyrosine phosphatase, non-receptor type 18
isoform 1 [Homo sapiens]
Length = 460
Score = 283 bits (724), Expect = 4e-76
Identities = 134/267 (50%), Positives = 183/267 (68%), Gaps = 2/267 (0%)
Query: 25 ANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSY 84
A EF ++ S +KAD T +P+N++KNRYKD+LPYD +RV LSL+ + S Y
Sbjct: 27 AGEFSDIQACSAAWKADGVCSTVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDY 86
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
IN NFI+GV G AYIATQGPL TLLDFWR++WE+ V +I+MAC E E G+K+CERYWA
Sbjct: 87 INGNFIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIENGRKRCERYWA 146
Query: 145 EPGEMQLEFGPFSVSCEAEK-RKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSID 203
+ E L+ G F ++ EK D ++RTLKV F E+R++YQ Y +WPD VPSS D
Sbjct: 147 QEQE-PLQTGLFCITLIKEKWLNEDIMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPD 205
Query: 204 PILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIR 263
+L ++ + R Q P+C+HCSAGCGRTGV+C +DY LL +IP +FS+F ++
Sbjct: 206 HMLAMVEEARRLQGSGPEPLCVHCSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVL 265
Query: 264 EMRTQRPSLVQTQEQYELVYNAVLELF 290
+MR QRP+ VQT+EQY +Y+ V ++F
Sbjct: 266 KMRKQRPAAVQTEEQYRFLYHTVAQMF 292
Score = 30.8 bits (68), Expect = 5.2
Identities = 11/19 (57%), Positives = 13/19 (68%)
Query: 787 GFANRFSKPKGPRNPPPTW 805
GF R +PKGPR+PP W
Sbjct: 439 GFNLRIGRPKGPRDPPAEW 457
>gi|196114967 protein tyrosine phosphatase, non-receptor type 12
isoform 2 [Homo sapiens]
Length = 661
Score = 275 bits (704), Expect = 9e-74
Identities = 206/599 (34%), Positives = 289/599 (48%), Gaps = 112/599 (18%)
Query: 116 MIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLK 175
MIWEY+V+IIVMAC E+EMG+KKCERYW GE + F PF +SCE E+ ++DY IRTL
Sbjct: 1 MIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLL 60
Query: 176 VKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTG 235
++F +E+R +YQFHY NWPDHDVPSS D IL++I +R YQE + VPICIHCSAGCGRTG
Sbjct: 61 LEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTG 120
Query: 236 VICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMD 295
ICAIDYTW LLK G IPE F+VF+LI+EMRTQR S VQT+EQYELV+ A+ +LF++Q+
Sbjct: 121 AICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQ 180
Query: 296 V--------IRD--KHSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTK 345
+ I D TE+ PEK DS P P++ + + + K
Sbjct: 181 LYEIHGAQKIADGVNEINTENMVSSIEPEKQ-----DSPPPKPPRTRS----CLVEGDAK 231
Query: 346 MEIKE---------------SSSFDFRTSEISAKEEL----VLHPAKSSTSFDFLELNYS 386
EI + S+F T+ + VLH S L NYS
Sbjct: 232 EEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYS 291
Query: 387 ---------------FDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEG------- 424
DK + + ++ K P+ P +S D +LL G
Sbjct: 292 KSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGP----KSFDGNTLLNRGHAIKIKS 347
Query: 425 ---C---SNSKP------VNAAGRYFNSKVPITRTKS-----TPFELIQQRETK------ 461
C SKP +N NS V + T+S TP E Q +T
Sbjct: 348 ASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRL 407
Query: 462 EVDSKENFSYLESQPHDSCFVEMQAQKVMHVSSAELNY------SLPYDSKHQIRNASNV 515
+D K + ++ P ++ + + +S+++NY SL Q+ V
Sbjct: 408 PLDEKGHVTWSFHGPENA----IPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLV 463
Query: 516 KHHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLF 575
H ++S PL P + P S DG V + +++++
Sbjct: 464 DHDNTS--------PLFRTPLSFTNPLHSDDSDSD---ERNSDGAVTQNKTNISTASATV 512
Query: 576 SYYNSHDSLSLNSPTNISSLLNQESAVLATAPR----IDDEIPPPLPVRTPESFIVVEE 630
S S +S+S +S + + + + ++ PPPLP RTPESF++ E
Sbjct: 513 SAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASE 571
Score = 59.3 bits (142), Expect = 1e-08
Identities = 38/116 (32%), Positives = 53/116 (45%), Gaps = 14/116 (12%)
Query: 694 PPPLPERTLESFFLADEDCMQAQSIETYSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLK 753
PPPLPERT ESF LA E ++T S +++ + + S++ K
Sbjct: 555 PPPLPERTPESFVLASE----------HNTPVRSEWSELQSQERSEQKKSEGLITSENEK 604
Query: 754 I---LRNMKKSICNSCPPNKPAESVQ-SNNSSSFLNFGFANRFSKPKGPRNPPPTW 805
+ +C CPP + Q S N + + GF NR KPKGPR+PP W
Sbjct: 605 CDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEW 660
>gi|196114970 protein tyrosine phosphatase, non-receptor type 12
isoform 3 [Homo sapiens]
Length = 650
Score = 256 bits (654), Expect = 6e-68
Identities = 197/588 (33%), Positives = 278/588 (47%), Gaps = 112/588 (19%)
Query: 127 MACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIY 186
MAC E+EMG+KKCERYW GE + F PF +SCE E+ ++DY IRTL ++F +E+R +Y
Sbjct: 1 MACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLY 60
Query: 187 QFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWML 246
QFHY NWPDHDVPSS D IL++I +R YQE + VPICIHCSAGCGRTG ICAIDYTW L
Sbjct: 61 QFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNL 120
Query: 247 LKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDV--------IR 298
LK G IPE F+VF+LI+EMRTQR S VQT+EQYELV+ A+ +LF++Q+ + I
Sbjct: 121 LKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIA 180
Query: 299 D--KHSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKE------ 350
D TE+ PEK DS P P++ + + + K EI +
Sbjct: 181 DGVNEINTENMVSSIEPEKQ-----DSPPPKPPRTRS----CLVEGDAKEEILQPPEPHP 231
Query: 351 ---------SSSFDFRTSEISAKEEL----VLHPAKSSTSFDFLELNYS----------- 386
S+F T+ + VLH S L NYS
Sbjct: 232 VPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNES 291
Query: 387 ----FDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEG----------C---SNSK 429
DK + + ++ K P+ P +S D +LL G C SK
Sbjct: 292 TIEQIDKKLERNLSFEIKKVPLQEGP----KSFDGNTLLNRGHAIKIKSASPCIADKISK 347
Query: 430 P------VNAAGRYFNSKVPITRTKS-----TPFELIQQRETK------EVDSKENFSYL 472
P +N NS V + T+S TP E Q +T +D K + ++
Sbjct: 348 PQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWS 407
Query: 473 ESQPHDSCFVEMQAQKVMHVSSAELNY------SLPYDSKHQIRNASNVKHHDSSALGVY 526
P ++ + + +S+++NY SL Q+ V H ++S
Sbjct: 408 FHGPENA----IPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTS----- 458
Query: 527 SYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSL 586
PL P + P S DG V + +++++ S S +S+S
Sbjct: 459 ---PLFRTPLSFTNPLHSDDSDSD---ERNSDGAVTQNKTNISTASATVSAATSTESIST 512
Query: 587 NSPTNISSLLNQESAVLATAPR----IDDEIPPPLPVRTPESFIVVEE 630
+S + + + + ++ PPPLP RTPESF++ E
Sbjct: 513 RKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASE 560
Score = 59.3 bits (142), Expect = 1e-08
Identities = 38/116 (32%), Positives = 53/116 (45%), Gaps = 14/116 (12%)
Query: 694 PPPLPERTLESFFLADEDCMQAQSIETYSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLK 753
PPPLPERT ESF LA E ++T S +++ + + S++ K
Sbjct: 544 PPPLPERTPESFVLASE----------HNTPVRSEWSELQSQERSEQKKSEGLITSENEK 593
Query: 754 I---LRNMKKSICNSCPPNKPAESVQ-SNNSSSFLNFGFANRFSKPKGPRNPPPTW 805
+ +C CPP + Q S N + + GF NR KPKGPR+PP W
Sbjct: 594 CDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEW 649
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 194 bits (494), Expect = 2e-49
Identities = 142/437 (32%), Positives = 202/437 (46%), Gaps = 26/437 (5%)
Query: 1 MDQREILQKFLDEAQSKKITKEE--FANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKN 58
M+ I L E +KI E F EF + R +K+ P A KP N KN
Sbjct: 578 MNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKF------PIKEARKPFNQNKN 631
Query: 59 RYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIW 118
RY DILPYDY+RVELS I D S+YINA++I G P+ YIA QGP T+ DFWRMIW
Sbjct: 632 RYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIW 691
Query: 119 EYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKV-- 176
E +IVM E + KC YW E FG V KR DYII+ L +
Sbjct: 692 EQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVN 751
Query: 177 -KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTG 235
K + R + + +WPDH VP +L+L V + S PI +HCSAG GRTG
Sbjct: 752 KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 811
Query: 236 VICAIDYTWMLLKDGIIPEN-FSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL--FKR 292
ID + +G+ EN V+ + ++R QR +VQ + QY L++ A++E F
Sbjct: 812 TYIGID----AMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGE 867
Query: 293 QMDVIRDKHSGTESQAKHCIPEKNHTLQADSYSPNLPK-STTKAAKMMNQQRTKMEIKES 351
+ + H + K P + L+A+ LP + + + NQ+ K + + S
Sbjct: 868 TEVNLSELHPYLHNMKKRDPPSEPSPLEAE--FQRLPSYRSWRTQHIGNQEENKSKNRNS 925
Query: 352 SSFDFRTSEISAKEELVL-----HPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVG 406
+ + + + K EL + H + S+ D S NA M + I
Sbjct: 926 NVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAA 985
Query: 407 EPLQKHQSLDLGSLLFE 423
+ K D ++F+
Sbjct: 986 QGPLKETIGDFWQMIFQ 1002
Score = 139 bits (351), Expect = 8e-33
Identities = 83/277 (29%), Positives = 139/277 (50%), Gaps = 37/277 (13%)
Query: 48 VAEKPKNIKKNRYKDILPYDYSRVEL-------------SLITSDEDSS------YINAN 88
+ + +N KNR +++PYDY+RV L S +SD+DS YINA+
Sbjct: 912 IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINAS 971
Query: 89 FIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGE 148
FI + P+ IA QGPL T+ DFW+MI++ V +IVM ++ C +YW GE
Sbjct: 972 FIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW---GE 1028
Query: 149 MQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPIL 206
+ +G V + + S Y +R +++ + ++RT+YQ+ Y NW +P+ ++
Sbjct: 1029 GKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELI 1088
Query: 207 ELIWDVR----------CYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENF 256
+I V+ + S P+ IHC G +TG+ CA+ LL+ E
Sbjct: 1089 SMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL---LNLLESAETEEVV 1145
Query: 257 SVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQ 293
+F +++ +R RP +V T EQY+ +Y+ + + Q
Sbjct: 1146 DIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQ 1182
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 194 bits (494), Expect = 2e-49
Identities = 142/437 (32%), Positives = 202/437 (46%), Gaps = 26/437 (5%)
Query: 1 MDQREILQKFLDEAQSKKITKEE--FANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKN 58
M+ I L E +KI E F EF + R +K+ P A KP N KN
Sbjct: 626 MNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKF------PIKEARKPFNQNKN 679
Query: 59 RYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIW 118
RY DILPYDY+RVELS I D S+YINA++I G P+ YIA QGP T+ DFWRMIW
Sbjct: 680 RYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIW 739
Query: 119 EYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKV-- 176
E +IVM E + KC YW E FG V KR DYII+ L +
Sbjct: 740 EQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVN 799
Query: 177 -KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTG 235
K + R + + +WPDH VP +L+L V + S PI +HCSAG GRTG
Sbjct: 800 KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 859
Query: 236 VICAIDYTWMLLKDGIIPEN-FSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL--FKR 292
ID + +G+ EN V+ + ++R QR +VQ + QY L++ A++E F
Sbjct: 860 TYIGID----AMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGE 915
Query: 293 QMDVIRDKHSGTESQAKHCIPEKNHTLQADSYSPNLPK-STTKAAKMMNQQRTKMEIKES 351
+ + H + K P + L+A+ LP + + + NQ+ K + + S
Sbjct: 916 TEVNLSELHPYLHNMKKRDPPSEPSPLEAE--FQRLPSYRSWRTQHIGNQEENKSKNRNS 973
Query: 352 SSFDFRTSEISAKEELVL-----HPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVG 406
+ + + + K EL + H + S+ D S NA M + I
Sbjct: 974 NVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAA 1033
Query: 407 EPLQKHQSLDLGSLLFE 423
+ K D ++F+
Sbjct: 1034 QGPLKETIGDFWQMIFQ 1050
Score = 139 bits (351), Expect = 8e-33
Identities = 83/277 (29%), Positives = 139/277 (50%), Gaps = 37/277 (13%)
Query: 48 VAEKPKNIKKNRYKDILPYDYSRVEL-------------SLITSDEDSS------YINAN 88
+ + +N KNR +++PYDY+RV L S +SD+DS YINA+
Sbjct: 960 IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINAS 1019
Query: 89 FIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGE 148
FI + P+ IA QGPL T+ DFW+MI++ V +IVM ++ C +YW GE
Sbjct: 1020 FIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW---GE 1076
Query: 149 MQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPIL 206
+ +G V + + S Y +R +++ + ++RT+YQ+ Y NW +P+ ++
Sbjct: 1077 GKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELI 1136
Query: 207 ELIWDVR----------CYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENF 256
+I V+ + S P+ IHC G +TG+ CA+ LL+ E
Sbjct: 1137 SMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL---LNLLESAETEEVV 1193
Query: 257 SVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQ 293
+F +++ +R RP +V T EQY+ +Y+ + + Q
Sbjct: 1194 DIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQ 1230
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform
2 precursor [Homo sapiens]
Length = 1143
Score = 194 bits (494), Expect = 2e-49
Identities = 142/437 (32%), Positives = 202/437 (46%), Gaps = 26/437 (5%)
Query: 1 MDQREILQKFLDEAQSKKITKEE--FANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKN 58
M+ I L E +KI E F EF + R +K+ P A KP N KN
Sbjct: 465 MNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKF------PIKEARKPFNQNKN 518
Query: 59 RYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIW 118
RY DILPYDY+RVELS I D S+YINA++I G P+ YIA QGP T+ DFWRMIW
Sbjct: 519 RYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIW 578
Query: 119 EYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKV-- 176
E +IVM E + KC YW E FG V KR DYII+ L +
Sbjct: 579 EQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVN 638
Query: 177 -KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTG 235
K + R + + +WPDH VP +L+L V + S PI +HCSAG GRTG
Sbjct: 639 KKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTG 698
Query: 236 VICAIDYTWMLLKDGIIPEN-FSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL--FKR 292
ID + +G+ EN V+ + ++R QR +VQ + QY L++ A++E F
Sbjct: 699 TYIGID----AMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGE 754
Query: 293 QMDVIRDKHSGTESQAKHCIPEKNHTLQADSYSPNLPK-STTKAAKMMNQQRTKMEIKES 351
+ + H + K P + L+A+ LP + + + NQ+ K + + S
Sbjct: 755 TEVNLSELHPYLHNMKKRDPPSEPSPLEAE--FQRLPSYRSWRTQHIGNQEENKSKNRNS 812
Query: 352 SSFDFRTSEISAKEELVL-----HPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVG 406
+ + + + K EL + H + S+ D S NA M + I
Sbjct: 813 NVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAA 872
Query: 407 EPLQKHQSLDLGSLLFE 423
+ K D ++F+
Sbjct: 873 QGPLKETIGDFWQMIFQ 889
Score = 139 bits (351), Expect = 8e-33
Identities = 83/277 (29%), Positives = 139/277 (50%), Gaps = 37/277 (13%)
Query: 48 VAEKPKNIKKNRYKDILPYDYSRVEL-------------SLITSDEDSS------YINAN 88
+ + +N KNR +++PYDY+RV L S +SD+DS YINA+
Sbjct: 799 IGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINAS 858
Query: 89 FIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGE 148
FI + P+ IA QGPL T+ DFW+MI++ V +IVM ++ C +YW GE
Sbjct: 859 FIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYW---GE 915
Query: 149 MQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPIL 206
+ +G V + + S Y +R +++ + ++RT+YQ+ Y NW +P+ ++
Sbjct: 916 GKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELI 975
Query: 207 ELIWDVR----------CYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENF 256
+I V+ + S P+ IHC G +TG+ CA+ LL+ E
Sbjct: 976 SMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL---LNLLESAETEEVV 1032
Query: 257 SVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQ 293
+F +++ +R RP +V T EQY+ +Y+ + + Q
Sbjct: 1033 DIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQ 1069
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 193 bits (491), Expect = 5e-49
Identities = 102/243 (41%), Positives = 148/243 (60%), Gaps = 10/243 (4%)
Query: 49 AEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLST 108
A++ +N KNRY +I+ YD+SRV L ++ D S YINAN+I G + P+ YIATQGP+
Sbjct: 907 AKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQE 966
Query: 109 TLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSD 168
T+ DFWRMIW+ + IVM E+G+ KC RYW + E+ +G V+ + ++
Sbjct: 967 TVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEV---YGDIKVTLIETEPLAE 1023
Query: 169 YIIRTLKV--KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIH 226
Y+IRT V K E R + FH+ +WPDH VP +L + V+ ++ PI +H
Sbjct: 1024 YVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVH 1083
Query: 227 CSAGCGRTGVICAIDYTW-MLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNA 285
CSAG GRTG AID M +G++ +F+ +RE+R QR +LVQT+EQY V++A
Sbjct: 1084 CSAGAGRTGCFIAIDTMLDMAENEGVV----DIFNCVRELRAQRVNLVQTEEQYVFVHDA 1139
Query: 286 VLE 288
+LE
Sbjct: 1140 ILE 1142
Score = 107 bits (267), Expect = 4e-23
Identities = 79/248 (31%), Positives = 122/248 (49%), Gaps = 22/248 (8%)
Query: 52 PKNIKKNRYKDILPYDYSRVELSLITSD-EDSSYINANFIKGVYGPKAYIATQGPLSTTL 110
P+N KNR D+LP D R LI+ D E S+YINA + P A++ TQ PL T+
Sbjct: 1200 PRNHDKNRSMDVLPLD--RCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTV 1257
Query: 111 LDFWRMIWEYSVLIIVMACMEYEMGKKK-CERYWAEPGEMQLEFGPFSVSCEAEKRKSDY 169
DFWR++++Y+ +VM EM + C +YW P + +GP V + D
Sbjct: 1258 ADFWRLVFDYNCSSVVML---NEMDTAQFCMQYW--PEKTSGCYGPIQVEFVSADIDEDI 1312
Query: 170 IIRTLKV----KFNSETRTIYQFHYKNWPDH-DVPSSIDPILELIWDVRCYQED---DSV 221
I R ++ + R + Y WP + D P S +L+++ + +QE
Sbjct: 1313 IHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREG 1372
Query: 222 PICIHCSAGCGRTGVICAI-DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYE 280
+HC G GR+G CAI M+ + II VF +++ +R + ++V+T EQY+
Sbjct: 1373 RTVVHCLNGGGRSGTFCAICSVCEMIQQQNII----DVFHIVKTLRNNKSNMVETLEQYK 1428
Query: 281 LVYNAVLE 288
VY LE
Sbjct: 1429 FVYEVALE 1436
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 193 bits (491), Expect = 5e-49
Identities = 102/243 (41%), Positives = 148/243 (60%), Gaps = 10/243 (4%)
Query: 49 AEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLST 108
A++ +N KNRY +I+ YD+SRV L ++ D S YINAN+I G + P+ YIATQGP+
Sbjct: 926 AKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQE 985
Query: 109 TLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSD 168
T+ DFWRMIW+ + IVM E+G+ KC RYW + E+ +G V+ + ++
Sbjct: 986 TVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEV---YGDIKVTLIETEPLAE 1042
Query: 169 YIIRTLKV--KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIH 226
Y+IRT V K E R + FH+ +WPDH VP +L + V+ ++ PI +H
Sbjct: 1043 YVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVH 1102
Query: 227 CSAGCGRTGVICAIDYTW-MLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNA 285
CSAG GRTG AID M +G++ +F+ +RE+R QR +LVQT+EQY V++A
Sbjct: 1103 CSAGAGRTGCFIAIDTMLDMAENEGVV----DIFNCVRELRAQRVNLVQTEEQYVFVHDA 1158
Query: 286 VLE 288
+LE
Sbjct: 1159 ILE 1161
Score = 107 bits (267), Expect = 4e-23
Identities = 79/248 (31%), Positives = 122/248 (49%), Gaps = 22/248 (8%)
Query: 52 PKNIKKNRYKDILPYDYSRVELSLITSD-EDSSYINANFIKGVYGPKAYIATQGPLSTTL 110
P+N KNR D+LP D R LI+ D E S+YINA + P A++ TQ PL T+
Sbjct: 1219 PRNHDKNRSMDVLPLD--RCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTV 1276
Query: 111 LDFWRMIWEYSVLIIVMACMEYEMGKKK-CERYWAEPGEMQLEFGPFSVSCEAEKRKSDY 169
DFWR++++Y+ +VM EM + C +YW P + +GP V + D
Sbjct: 1277 ADFWRLVFDYNCSSVVML---NEMDTAQFCMQYW--PEKTSGCYGPIQVEFVSADIDEDI 1331
Query: 170 IIRTLKV----KFNSETRTIYQFHYKNWPDH-DVPSSIDPILELIWDVRCYQED---DSV 221
I R ++ + R + Y WP + D P S +L+++ + +QE
Sbjct: 1332 IHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREG 1391
Query: 222 PICIHCSAGCGRTGVICAI-DYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYE 280
+HC G GR+G CAI M+ + II VF +++ +R + ++V+T EQY+
Sbjct: 1392 RTVVHCLNGGGRSGTFCAICSVCEMIQQQNII----DVFHIVKTLRNNKSNMVETLEQYK 1447
Query: 281 LVYNAVLE 288
VY LE
Sbjct: 1448 FVYEVALE 1455
>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
precursor [Homo sapiens]
Length = 1337
Score = 193 bits (490), Expect = 6e-49
Identities = 112/294 (38%), Positives = 162/294 (55%), Gaps = 19/294 (6%)
Query: 15 QSKKITKEEFANEFLKLKRQSTKYKADK---------TYPTTVAEKPKNIKKNRYKDILP 65
+SK I E F F K + S A++ + P AE +N KNRY ++LP
Sbjct: 1017 KSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLVGISQPKYAAELAENRGKNRYNNVLP 1076
Query: 66 YDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLII 125
YD SRV+LS+ T D YINAN++ G + K +IATQGPL TL DFWRM+WE +V I
Sbjct: 1077 YDISRVKLSVQTHSTDD-YINANYMPGYHSKKDFIATQGPLPNTLKDFWRMVWEKNVYAI 1135
Query: 126 VMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK--FNSETR 183
+M E G+ KCE YW P + ++G +V+ +E ++ IR VK SE+
Sbjct: 1136 IMLTKCVEQGRTKCEEYW--PSKQAQDYGDITVAMTSEIVLPEWTIRDFTVKNIQTSESH 1193
Query: 184 TIYQFHYKNWPDHDVPSSIDPILELIWDVRCY--QEDDSVPICIHCSAGCGRTGVICAID 241
+ QFH+ +WPDH VP + D ++ + VR Y Q PI +HCSAG GRTG AID
Sbjct: 1194 PLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVHCSAGVGRTGTFIAID 1253
Query: 242 YTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMD 295
+++ V+ ++ ++R RP +VQT++QY + VL++ + Q D
Sbjct: 1254 RLIYQIEN---ENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIVRSQKD 1304
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 190 bits (483), Expect = 4e-48
Identities = 98/244 (40%), Positives = 148/244 (60%), Gaps = 10/244 (4%)
Query: 48 VAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLS 107
VA+K +N KNRY +I+ YD+SRV L + D S YINAN+I G P YIATQGP+
Sbjct: 905 VAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVH 964
Query: 108 TTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKS 167
T+ DFWRMIW+ IVM E+G+ KC +YW + E+ +G F V+C + +
Sbjct: 965 ETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEV---YGDFKVTCVEMEPLA 1021
Query: 168 DYIIR--TLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICI 225
+Y++R TL+ + +E R + QFH+ WPDH VP +L I V+ + PI +
Sbjct: 1022 EYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVV 1081
Query: 226 HCSAGCGRTGVICAIDYTW-MLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYN 284
HCSAG GRTG ID M ++G++ +++ ++ +R++R ++VQT+EQY +++
Sbjct: 1082 HCSAGAGRTGCYIVIDIMLDMAEREGVV----DIYNCVKALRSRRINMVQTEEQYIFIHD 1137
Query: 285 AVLE 288
A+LE
Sbjct: 1138 AILE 1141
Score = 129 bits (324), Expect = 1e-29
Identities = 92/272 (33%), Positives = 138/272 (50%), Gaps = 21/272 (7%)
Query: 26 NEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSD-EDSSY 84
+EF L + + +A+ ++A P+N KNR+ D+LP D R LIT D E S+Y
Sbjct: 1176 DEFQTLNSVTPRLQAEDC---SIACLPRNHDKNRFMDMLPPD--RCLPFLITIDGESSNY 1230
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
INA + P A+I TQ PL T+ DFWR++++Y IVM E ++ + C +YW
Sbjct: 1231 INAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM-LNEVDL-SQGCPQYWP 1288
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIY----QFHYKNWPDH-DVP 199
E G L +GP V C + D I R ++ + + Y QF Y W H +VP
Sbjct: 1289 EEG--MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVP 1346
Query: 200 SSIDPILELIWDVRCYQ---EDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENF 256
S L+LI V +Q E+ IHC G GR+G+ CAI ++K + +
Sbjct: 1347 GSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVD-- 1404
Query: 257 SVFSLIREMRTQRPSLVQTQEQYELVYNAVLE 288
VF ++ +R +P++V+ EQY Y+ LE
Sbjct: 1405 -VFHAVKTLRNSKPNMVEAPEQYRFCYDVALE 1435
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 187 bits (476), Expect = 3e-47
Identities = 96/260 (36%), Positives = 150/260 (57%), Gaps = 10/260 (3%)
Query: 32 KRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIK 91
K + + ++ P A+K +N KNRY +I+ YD+SRV L I D +S YIN N+I
Sbjct: 901 KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID 960
Query: 92 GVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQL 151
G + P YIATQGP+ T+ DFWRM+W + I+M E+G+ KC +YW + E+
Sbjct: 961 GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEI-- 1018
Query: 152 EFGPFSVSCEAEKRKSDYIIRTLKVKFNS--ETRTIYQFHYKNWPDHDVPSSIDPILELI 209
+ V+ + ++Y+IRT V+ E R I QFH+ WPDH VP +L +
Sbjct: 1019 -YKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFV 1077
Query: 210 WDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTW-MLLKDGIIPENFSVFSLIREMRTQ 268
V+ + P+ +HCSAG GRTG ID M ++G++ +++ +RE+R++
Sbjct: 1078 RQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVV----DIYNCVRELRSR 1133
Query: 269 RPSLVQTQEQYELVYNAVLE 288
R ++VQT+EQY +++A+LE
Sbjct: 1134 RVNMVQTEEQYVFIHDAILE 1153
Score = 115 bits (289), Expect = 1e-25
Identities = 83/252 (32%), Positives = 123/252 (48%), Gaps = 20/252 (7%)
Query: 47 TVAEKPKNIKKNRYKDILPYDYSRVELSLITSD-EDSSYINANFIKGVYGPKAYIATQGP 105
++A P+N +KNR DILP D R LIT D E S+YINA + P A+I TQ P
Sbjct: 1206 SIALLPRNHEKNRCMDILPPD--RCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHP 1263
Query: 106 LSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKR 165
L T+ DFWR++ +Y +VM + + C +YW E G + GP V +
Sbjct: 1264 LPNTVKDFWRLVLDYHCTSVVM--LNDVDPAQLCPQYWPENGVHR--HGPIQVEFVSADL 1319
Query: 166 KSDYIIRTLKVKFNSET-----RTIYQFHYKNWPDH-DVPSSIDPILELIWDVRCYQED- 218
+ D I R ++ +N+ R + QF + WP + D P S L+LI V +QE+
Sbjct: 1320 EEDIISRIFRI-YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEY 1378
Query: 219 --DSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQ 276
+HC G GR+G CAI +L+ VF ++ +R +P++V
Sbjct: 1379 NGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH---QRTVDVFHAVKTLRNNKPNMVDLL 1435
Query: 277 EQYELVYNAVLE 288
+QY+ Y LE
Sbjct: 1436 DQYKFCYEVALE 1447
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 187 bits (476), Expect = 3e-47
Identities = 96/260 (36%), Positives = 150/260 (57%), Gaps = 10/260 (3%)
Query: 32 KRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIK 91
K + + ++ P A+K +N KNRY +I+ YD+SRV L I D +S YIN N+I
Sbjct: 914 KEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYID 973
Query: 92 GVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQL 151
G + P YIATQGP+ T+ DFWRM+W + I+M E+G+ KC +YW + E+
Sbjct: 974 GYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEI-- 1031
Query: 152 EFGPFSVSCEAEKRKSDYIIRTLKVKFNS--ETRTIYQFHYKNWPDHDVPSSIDPILELI 209
+ V+ + ++Y+IRT V+ E R I QFH+ WPDH VP +L +
Sbjct: 1032 -YKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFV 1090
Query: 210 WDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTW-MLLKDGIIPENFSVFSLIREMRTQ 268
V+ + P+ +HCSAG GRTG ID M ++G++ +++ +RE+R++
Sbjct: 1091 RQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVV----DIYNCVRELRSR 1146
Query: 269 RPSLVQTQEQYELVYNAVLE 288
R ++VQT+EQY +++A+LE
Sbjct: 1147 RVNMVQTEEQYVFIHDAILE 1166
Score = 115 bits (289), Expect = 1e-25
Identities = 83/252 (32%), Positives = 123/252 (48%), Gaps = 20/252 (7%)
Query: 47 TVAEKPKNIKKNRYKDILPYDYSRVELSLITSD-EDSSYINANFIKGVYGPKAYIATQGP 105
++A P+N +KNR DILP D R LIT D E S+YINA + P A+I TQ P
Sbjct: 1219 SIALLPRNHEKNRCMDILPPD--RCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHP 1276
Query: 106 LSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKR 165
L T+ DFWR++ +Y +VM + + C +YW E G + GP V +
Sbjct: 1277 LPNTVKDFWRLVLDYHCTSVVM--LNDVDPAQLCPQYWPENGVHR--HGPIQVEFVSADL 1332
Query: 166 KSDYIIRTLKVKFNSET-----RTIYQFHYKNWPDH-DVPSSIDPILELIWDVRCYQED- 218
+ D I R ++ +N+ R + QF + WP + D P S L+LI V +QE+
Sbjct: 1333 EEDIISRIFRI-YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEY 1391
Query: 219 --DSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQ 276
+HC G GR+G CAI +L+ VF ++ +R +P++V
Sbjct: 1392 NGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRH---QRTVDVFHAVKTLRNNKPNMVDLL 1448
Query: 277 EQYELVYNAVLE 288
+QY+ Y LE
Sbjct: 1449 DQYKFCYEVALE 1460
>gi|18104989 protein tyrosine phosphatase, non-receptor type 6
isoform 1 [Homo sapiens]
Length = 595
Score = 184 bits (467), Expect = 3e-46
Identities = 120/366 (32%), Positives = 186/366 (50%), Gaps = 19/366 (5%)
Query: 15 QSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELS 74
+S+ K F EF L++Q K + ++P+N KNRYK+ILP+D+SRV L
Sbjct: 235 ESEDTAKAGFWEEFESLQKQEVK----NLHQRLEGQRPENKGKNRYKNILPFDHSRVILQ 290
Query: 75 LITSD-EDSSYINANFIKG-VYGP----KAYIATQGPLSTTLLDFWRMIWEYSVLIIVMA 128
S+ S YINAN+IK + GP K YIA+QG L T+ DFW+M W+ + +IVM
Sbjct: 291 GRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMT 350
Query: 129 CMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK---FNSETRTI 185
E E G+ KC YW E G MQ +GP+SV+ E ++Y +RTL+V R I
Sbjct: 351 TREVEKGRNKCVPYWPEVG-MQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREI 409
Query: 186 YQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAIDYT 243
+ + Y +WPDH VPS +L + + QE + PI +HCSAG GRTG I ID
Sbjct: 410 WHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDML 469
Query: 244 WMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAV---LELFKRQMDVIRDK 300
+ + + + I+ +R QR +VQT+ QY+ +Y A+ +E K++++V++ +
Sbjct: 470 MENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQ 529
Query: 301 HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE 360
P A + + + + + + ++K+ S D S+
Sbjct: 530 KGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSK 589
Query: 361 ISAKEE 366
S K +
Sbjct: 590 GSLKRK 595
>gi|18104991 protein tyrosine phosphatase, non-receptor type 6
isoform 2 [Homo sapiens]
Length = 597
Score = 184 bits (467), Expect = 3e-46
Identities = 120/366 (32%), Positives = 186/366 (50%), Gaps = 19/366 (5%)
Query: 15 QSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELS 74
+S+ K F EF L++Q K + ++P+N KNRYK+ILP+D+SRV L
Sbjct: 237 ESEDTAKAGFWEEFESLQKQEVK----NLHQRLEGQRPENKGKNRYKNILPFDHSRVILQ 292
Query: 75 LITSD-EDSSYINANFIKG-VYGP----KAYIATQGPLSTTLLDFWRMIWEYSVLIIVMA 128
S+ S YINAN+IK + GP K YIA+QG L T+ DFW+M W+ + +IVM
Sbjct: 293 GRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMT 352
Query: 129 CMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK---FNSETRTI 185
E E G+ KC YW E G MQ +GP+SV+ E ++Y +RTL+V R I
Sbjct: 353 TREVEKGRNKCVPYWPEVG-MQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREI 411
Query: 186 YQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAIDYT 243
+ + Y +WPDH VPS +L + + QE + PI +HCSAG GRTG I ID
Sbjct: 412 WHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDML 471
Query: 244 WMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAV---LELFKRQMDVIRDK 300
+ + + + I+ +R QR +VQT+ QY+ +Y A+ +E K++++V++ +
Sbjct: 472 MENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQ 531
Query: 301 HSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSE 360
P A + + + + + + ++K+ S D S+
Sbjct: 532 KGQESEYGNITYPPAMKNAHAKASRTSSKHKEDVYENLHTKNKREEKVKKQRSADKEKSK 591
Query: 361 ISAKEE 366
S K +
Sbjct: 592 GSLKRK 597
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 184 bits (466), Expect = 4e-46
Identities = 98/250 (39%), Positives = 148/250 (59%), Gaps = 16/250 (6%)
Query: 48 VAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIK------GVYGPKAYIA 101
VA+K +N KNRY +I+ YD+SRV L + D S YINAN+I G P YIA
Sbjct: 905 VAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIA 964
Query: 102 TQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCE 161
TQGP+ T+ DFWRMIW+ IVM E+G+ KC +YW + E+ +G F V+C
Sbjct: 965 TQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEV---YGDFKVTCV 1021
Query: 162 AEKRKSDYIIR--TLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDD 219
+ ++Y++R TL+ + +E R + QFH+ WPDH VP +L I V+
Sbjct: 1022 EMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPS 1081
Query: 220 SVPICIHCSAGCGRTGVICAIDYTW-MLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQ 278
+ PI +HCSAG GRTG ID M ++G++ +++ ++ +R++R ++VQT+EQ
Sbjct: 1082 AGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVV----DIYNCVKALRSRRINMVQTEEQ 1137
Query: 279 YELVYNAVLE 288
Y +++A+LE
Sbjct: 1138 YIFIHDAILE 1147
Score = 129 bits (324), Expect = 1e-29
Identities = 92/272 (33%), Positives = 138/272 (50%), Gaps = 21/272 (7%)
Query: 26 NEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSD-EDSSY 84
+EF L + + +A+ ++A P+N KNR+ D+LP D R LIT D E S+Y
Sbjct: 1182 DEFQTLNSVTPRLQAEDC---SIACLPRNHDKNRFMDMLPPD--RCLPFLITIDGESSNY 1236
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
INA + P A+I TQ PL T+ DFWR++++Y IVM E ++ + C +YW
Sbjct: 1237 INAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM-LNEVDL-SQGCPQYWP 1294
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIY----QFHYKNWPDH-DVP 199
E G L +GP V C + D I R ++ + + Y QF Y W H +VP
Sbjct: 1295 EEG--MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVP 1352
Query: 200 SSIDPILELIWDVRCYQ---EDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENF 256
S L+LI V +Q E+ IHC G GR+G+ CAI ++K + +
Sbjct: 1353 GSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVD-- 1410
Query: 257 SVFSLIREMRTQRPSLVQTQEQYELVYNAVLE 288
VF ++ +R +P++V+ EQY Y+ LE
Sbjct: 1411 -VFHAVKTLRNSKPNMVEAPEQYRFCYDVALE 1441
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 184 bits (466), Expect = 4e-46
Identities = 106/282 (37%), Positives = 158/282 (56%), Gaps = 13/282 (4%)
Query: 14 AQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTV--AEKPKNIKKNRYKDILPYDYSRV 71
A +K+T+ E ++ + + + K + + A P N KNR +I+PY+ +RV
Sbjct: 1217 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1276
Query: 72 ELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACME 131
L I E S YINA+FI G KAYIATQGPL+ T DFWRM+WE++ I+VM
Sbjct: 1277 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1336
Query: 132 YEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKV--KFNSETRTIYQFH 189
EMG++KC +YW P E + F V AE YI+R KV + ++RT+ QF
Sbjct: 1337 REMGREKCHQYW--PAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1394
Query: 190 YKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAIDYTWMLL 247
+ +WP+ VP S + ++ I V +E PI +HCSAG GRTGV + +
Sbjct: 1395 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1454
Query: 248 K-DGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE 288
+ +G++ +F ++ +RTQRP++VQT++QY+ Y A LE
Sbjct: 1455 RYEGVV----DIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE 1492
Score = 161 bits (408), Expect = 2e-39
Identities = 95/266 (35%), Positives = 134/266 (50%), Gaps = 7/266 (2%)
Query: 25 ANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSY 84
AN+ LK ++ + + + N KNRY +++ YD+SRV LS I S Y
Sbjct: 941 ANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDY 1000
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
+NAN+I G AYIATQG L T DFWRMIWE +VM E + KC++YW
Sbjct: 1001 VNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW- 1059
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSI 202
P G V+ + Y +RT + N SE R + QF + WPDH VP
Sbjct: 1060 -PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHP 1118
Query: 203 DPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLI 262
P L + V+ D+ P+ +HCSAG GRTG ID +K + ++ +
Sbjct: 1119 TPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHV 1175
Query: 263 REMRTQRPSLVQTQEQYELVYNAVLE 288
MR QR +VQT++QY +++A+LE
Sbjct: 1176 TLMRAQRNYMVQTEDQYIFIHDALLE 1201
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 184 bits (466), Expect = 4e-46
Identities = 106/282 (37%), Positives = 158/282 (56%), Gaps = 13/282 (4%)
Query: 14 AQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTV--AEKPKNIKKNRYKDILPYDYSRV 71
A +K+T+ E ++ + + + K + + A P N KNR +I+PY+ +RV
Sbjct: 1627 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1686
Query: 72 ELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACME 131
L I E S YINA+FI G KAYIATQGPL+ T DFWRM+WE++ I+VM
Sbjct: 1687 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1746
Query: 132 YEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKV--KFNSETRTIYQFH 189
EMG++KC +YW P E + F V AE YI+R KV + ++RT+ QF
Sbjct: 1747 REMGREKCHQYW--PAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1804
Query: 190 YKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAIDYTWMLL 247
+ +WP+ VP S + ++ I V +E PI +HCSAG GRTGV + +
Sbjct: 1805 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1864
Query: 248 K-DGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE 288
+ +G++ +F ++ +RTQRP++VQT++QY+ Y A LE
Sbjct: 1865 RYEGVV----DIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE 1902
Score = 161 bits (408), Expect = 2e-39
Identities = 95/266 (35%), Positives = 134/266 (50%), Gaps = 7/266 (2%)
Query: 25 ANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSY 84
AN+ LK ++ + + + N KNRY +++ YD+SRV LS I S Y
Sbjct: 1351 ANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDY 1410
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
+NAN+I G AYIATQG L T DFWRMIWE +VM E + KC++YW
Sbjct: 1411 VNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW- 1469
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSI 202
P G V+ + Y +RT + N SE R + QF + WPDH VP
Sbjct: 1470 -PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHP 1528
Query: 203 DPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLI 262
P L + V+ D+ P+ +HCSAG GRTG ID +K + ++ +
Sbjct: 1529 TPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHV 1585
Query: 263 REMRTQRPSLVQTQEQYELVYNAVLE 288
MR QR +VQT++QY +++A+LE
Sbjct: 1586 TLMRAQRNYMVQTEDQYIFIHDALLE 1611
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 184 bits (466), Expect = 4e-46
Identities = 106/282 (37%), Positives = 158/282 (56%), Gaps = 13/282 (4%)
Query: 14 AQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTV--AEKPKNIKKNRYKDILPYDYSRV 71
A +K+T+ E ++ + + + K + + A P N KNR +I+PY+ +RV
Sbjct: 1614 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1673
Query: 72 ELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACME 131
L I E S YINA+FI G KAYIATQGPL+ T DFWRM+WE++ I+VM
Sbjct: 1674 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1733
Query: 132 YEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKV--KFNSETRTIYQFH 189
EMG++KC +YW P E + F V AE YI+R KV + ++RT+ QF
Sbjct: 1734 REMGREKCHQYW--PAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1791
Query: 190 YKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAIDYTWMLL 247
+ +WP+ VP S + ++ I V +E PI +HCSAG GRTGV + +
Sbjct: 1792 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1851
Query: 248 K-DGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE 288
+ +G++ +F ++ +RTQRP++VQT++QY+ Y A LE
Sbjct: 1852 RYEGVV----DIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE 1889
Score = 161 bits (408), Expect = 2e-39
Identities = 95/266 (35%), Positives = 134/266 (50%), Gaps = 7/266 (2%)
Query: 25 ANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSY 84
AN+ LK ++ + + + N KNRY +++ YD+SRV LS I S Y
Sbjct: 1338 ANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDY 1397
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
+NAN+I G AYIATQG L T DFWRMIWE +VM E + KC++YW
Sbjct: 1398 VNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW- 1456
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSI 202
P G V+ + Y +RT + N SE R + QF + WPDH VP
Sbjct: 1457 -PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHP 1515
Query: 203 DPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLI 262
P L + V+ D+ P+ +HCSAG GRTG ID +K + ++ +
Sbjct: 1516 TPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHV 1572
Query: 263 REMRTQRPSLVQTQEQYELVYNAVLE 288
MR QR +VQT++QY +++A+LE
Sbjct: 1573 TLMRAQRNYMVQTEDQYIFIHDALLE 1598
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 184 bits (466), Expect = 4e-46
Identities = 106/282 (37%), Positives = 158/282 (56%), Gaps = 13/282 (4%)
Query: 14 AQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTV--AEKPKNIKKNRYKDILPYDYSRV 71
A +K+T+ E ++ + + + K + + A P N KNR +I+PY+ +RV
Sbjct: 1618 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1677
Query: 72 ELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACME 131
L I E S YINA+FI G KAYIATQGPL+ T DFWRM+WE++ I+VM
Sbjct: 1678 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1737
Query: 132 YEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKV--KFNSETRTIYQFH 189
EMG++KC +YW P E + F V AE YI+R KV + ++RT+ QF
Sbjct: 1738 REMGREKCHQYW--PAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1795
Query: 190 YKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAIDYTWMLL 247
+ +WP+ VP S + ++ I V +E PI +HCSAG GRTGV + +
Sbjct: 1796 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1855
Query: 248 K-DGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE 288
+ +G++ +F ++ +RTQRP++VQT++QY+ Y A LE
Sbjct: 1856 RYEGVV----DIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE 1893
Score = 161 bits (408), Expect = 2e-39
Identities = 95/266 (35%), Positives = 134/266 (50%), Gaps = 7/266 (2%)
Query: 25 ANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSY 84
AN+ LK ++ + + + N KNRY +++ YD+SRV LS I S Y
Sbjct: 1342 ANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDY 1401
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
+NAN+I G AYIATQG L T DFWRMIWE +VM E + KC++YW
Sbjct: 1402 VNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW- 1460
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSI 202
P G V+ + Y +RT + N SE R + QF + WPDH VP
Sbjct: 1461 -PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHP 1519
Query: 203 DPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLI 262
P L + V+ D+ P+ +HCSAG GRTG ID +K + ++ +
Sbjct: 1520 TPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHV 1576
Query: 263 REMRTQRPSLVQTQEQYELVYNAVLE 288
MR QR +VQT++QY +++A+LE
Sbjct: 1577 TLMRAQRNYMVQTEDQYIFIHDALLE 1602
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 184 bits (466), Expect = 4e-46
Identities = 106/282 (37%), Positives = 158/282 (56%), Gaps = 13/282 (4%)
Query: 14 AQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTV--AEKPKNIKKNRYKDILPYDYSRV 71
A +K+T+ E ++ + + + K + + A P N KNR +I+PY+ +RV
Sbjct: 1216 AYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1275
Query: 72 ELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACME 131
L I E S YINA+FI G KAYIATQGPL+ T DFWRM+WE++ I+VM
Sbjct: 1276 CLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKL 1335
Query: 132 YEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKV--KFNSETRTIYQFH 189
EMG++KC +YW P E + F V AE YI+R KV + ++RT+ QF
Sbjct: 1336 REMGREKCHQYW--PAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1393
Query: 190 YKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAIDYTWMLL 247
+ +WP+ VP S + ++ I V +E PI +HCSAG GRTGV + +
Sbjct: 1394 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1453
Query: 248 K-DGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE 288
+ +G++ +F ++ +RTQRP++VQT++QY+ Y A LE
Sbjct: 1454 RYEGVV----DIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE 1491
Score = 161 bits (408), Expect = 2e-39
Identities = 95/266 (35%), Positives = 134/266 (50%), Gaps = 7/266 (2%)
Query: 25 ANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSY 84
AN+ LK ++ + + + N KNRY +++ YD+SRV LS I S Y
Sbjct: 940 ANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDY 999
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
+NAN+I G AYIATQG L T DFWRMIWE +VM E + KC++YW
Sbjct: 1000 VNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYW- 1058
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSI 202
P G V+ + Y +RT + N SE R + QF + WPDH VP
Sbjct: 1059 -PSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHP 1117
Query: 203 DPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLI 262
P L + V+ D+ P+ +HCSAG GRTG ID +K + ++ +
Sbjct: 1118 TPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKH---EKTVDIYGHV 1174
Query: 263 REMRTQRPSLVQTQEQYELVYNAVLE 288
MR QR +VQT++QY +++A+LE
Sbjct: 1175 TLMRAQRNYMVQTEDQYIFIHDALLE 1200
>gi|18104993 protein tyrosine phosphatase, non-receptor type 6
isoform 3 [Homo sapiens]
Length = 624
Score = 184 bits (466), Expect = 4e-46
Identities = 115/307 (37%), Positives = 171/307 (55%), Gaps = 20/307 (6%)
Query: 15 QSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELS 74
+S+ K F EF L++Q K + ++P+N KNRYK+ILP+D+SRV L
Sbjct: 235 ESEDTAKAGFWEEFESLQKQEVK----NLHQRLEGQRPENKGKNRYKNILPFDHSRVILQ 290
Query: 75 LITSD-EDSSYINANFIKG-VYGP----KAYIATQGPLSTTLLDFWRMIWEYSVLIIVMA 128
S+ S YINAN+IK + GP K YIA+QG L T+ DFW+M W+ + +IVM
Sbjct: 291 GRDSNIPGSDYINANYIKNQLLGPDENAKTYIASQGCLEATVNDFWQMAWQENSRVIVMT 350
Query: 129 CMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK---FNSETRTI 185
E E G+ KC YW E G MQ +GP+SV+ E ++Y +RTL+V R I
Sbjct: 351 TREVEKGRNKCVPYWPEVG-MQRAYGPYSVTNCGEHDTTEYKLRTLQVSPLDNGDLIREI 409
Query: 186 YQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAIDYT 243
+ + Y +WPDH VPS +L + + QE + PI +HCSAG GRTG I ID
Sbjct: 410 WHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDML 469
Query: 244 WMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAV---LELFKRQMDVIRDK 300
+ + + + I+ +R QR +VQT+ QY+ +Y A+ +E K++++V++ +
Sbjct: 470 MENISTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEVLQSQ 529
Query: 301 HSGTESQ 307
G ES+
Sbjct: 530 -KGQESE 535
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 181 bits (460), Expect = 2e-45
Identities = 101/245 (41%), Positives = 144/245 (58%), Gaps = 11/245 (4%)
Query: 49 AEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLST 108
A P N KNR +I+PY+ +RV L I E S YINA+F+ G KAYIATQGPL+
Sbjct: 1659 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1718
Query: 109 TLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSD 168
+ DFWRM+WE++ IIVM EMG++KC +YW P E + F V AE
Sbjct: 1719 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYW--PAERSARYQYFVVDPMAEYNMPQ 1776
Query: 169 YIIRTLKV--KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPIC 224
YI+R KV + ++RTI QF + +WP+ VP + + ++ I V +E PI
Sbjct: 1777 YILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPIT 1836
Query: 225 IHCSAGCGRTGVICAIDYTWMLLK-DGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVY 283
+HCSAG GRTGV + ++ +G++ +F ++ +RTQRP++VQT++QY+L Y
Sbjct: 1837 VHCSAGVGRTGVFITLSIVLERMRYEGVV----DMFQTVKTLRTQRPAMVQTEDQYQLCY 1892
Query: 284 NAVLE 288
A LE
Sbjct: 1893 RAALE 1897
Score = 164 bits (414), Expect = 4e-40
Identities = 96/266 (36%), Positives = 137/266 (51%), Gaps = 7/266 (2%)
Query: 25 ANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSY 84
AN+ LK ++ + + + N KNRY +++ YD+SRV L+ I S Y
Sbjct: 1346 ANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDY 1405
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
INAN+I G AYIATQGPL T+ DFWRM+WE +VM E + KC++YW
Sbjct: 1406 INANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYW- 1464
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRT--LKVKFNSETRTIYQFHYKNWPDHDVPSSI 202
P G V+ + Y +RT L +SE R + QF + WPDH VP
Sbjct: 1465 -PARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYP 1523
Query: 203 DPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLI 262
PIL + V+ D+ P+ +HCSAG GRTG ID +K + ++ +
Sbjct: 1524 TPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKH---EKTVDIYGHV 1580
Query: 263 REMRTQRPSLVQTQEQYELVYNAVLE 288
MR+QR +VQT++QY ++ A+LE
Sbjct: 1581 TCMRSQRNYMVQTEDQYVFIHEALLE 1606
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 181 bits (460), Expect = 2e-45
Identities = 101/245 (41%), Positives = 144/245 (58%), Gaps = 11/245 (4%)
Query: 49 AEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLST 108
A P N KNR +I+PY+ +RV L I E S YINA+F+ G KAYIATQGPL+
Sbjct: 1650 ANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAE 1709
Query: 109 TLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSD 168
+ DFWRM+WE++ IIVM EMG++KC +YW P E + F V AE
Sbjct: 1710 STEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYW--PAERSARYQYFVVDPMAEYNMPQ 1767
Query: 169 YIIRTLKV--KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPIC 224
YI+R KV + ++RTI QF + +WP+ VP + + ++ I V +E PI
Sbjct: 1768 YILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPIT 1827
Query: 225 IHCSAGCGRTGVICAIDYTWMLLK-DGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVY 283
+HCSAG GRTGV + ++ +G++ +F ++ +RTQRP++VQT++QY+L Y
Sbjct: 1828 VHCSAGVGRTGVFITLSIVLERMRYEGVV----DMFQTVKTLRTQRPAMVQTEDQYQLCY 1883
Query: 284 NAVLE 288
A LE
Sbjct: 1884 RAALE 1888
Score = 164 bits (414), Expect = 4e-40
Identities = 96/266 (36%), Positives = 137/266 (51%), Gaps = 7/266 (2%)
Query: 25 ANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSY 84
AN+ LK ++ + + + N KNRY +++ YD+SRV L+ I S Y
Sbjct: 1337 ANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDY 1396
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
INAN+I G AYIATQGPL T+ DFWRM+WE +VM E + KC++YW
Sbjct: 1397 INANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYW- 1455
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRT--LKVKFNSETRTIYQFHYKNWPDHDVPSSI 202
P G V+ + Y +RT L +SE R + QF + WPDH VP
Sbjct: 1456 -PARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYP 1514
Query: 203 DPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLI 262
PIL + V+ D+ P+ +HCSAG GRTG ID +K + ++ +
Sbjct: 1515 TPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKH---EKTVDIYGHV 1571
Query: 263 REMRTQRPSLVQTQEQYELVYNAVLE 288
MR+QR +VQT++QY ++ A+LE
Sbjct: 1572 TCMRSQRNYMVQTEDQYVFIHEALLE 1597
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 181 bits (458), Expect = 3e-45
Identities = 104/280 (37%), Positives = 151/280 (53%), Gaps = 24/280 (8%)
Query: 24 FANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDED-- 81
F+ +F +++R + AD + P+N KNRY +IL YD+SRV+L + +
Sbjct: 848 FSEDFEEVQRCT----ADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKH 903
Query: 82 SSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCER 141
S YINAN++ G KAYIATQGPL +T DFWRMIWE + IIVM E G++KC++
Sbjct: 904 SDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQ 963
Query: 142 YWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKV-------------KFNSETRTIYQF 188
YW P E E+G V+ ++ K + Y +R + K R + Q+
Sbjct: 964 YW--PTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQY 1021
Query: 189 HYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLK 248
HY WPD VP P+L + + ++ P+ +HCSAG GRTG ID +K
Sbjct: 1022 HYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIK 1081
Query: 249 DGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE 288
D +V ++ +RTQR LVQT+EQY +++A+LE
Sbjct: 1082 D---KSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE 1118
Score = 97.4 bits (241), Expect = 5e-20
Identities = 73/252 (28%), Positives = 116/252 (46%), Gaps = 22/252 (8%)
Query: 49 AEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLST 108
A+K N +KNR ++P + +RV L+ + + + YINA++I G Y +I TQ PL
Sbjct: 1170 AQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPH 1229
Query: 109 TLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRK-- 166
T DFWRMIW+++ IIVM + + + YW E + F+V+ ++ R
Sbjct: 1230 TTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPS-REESMNCEAFTVTLISKDRLCL 1287
Query: 167 --------SDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED 218
D+I+ + + E R F WP+ D P I ELI ++
Sbjct: 1288 SNEEQIIIHDFILEATQDDYVLEVR---HFQCPKWPNPDAP--ISSTFELINVIKEEALT 1342
Query: 219 DSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPEN-FSVFSLIREMRTQRPSLVQTQE 277
P +H G G++CA+ L + EN VF + + + RP + E
Sbjct: 1343 RDGPTIVHDEYGAVSAGMLCAL----TTLSQQLENENAVDVFQVAKMINLMRPGVFTDIE 1398
Query: 278 QYELVYNAVLEL 289
QY+ +Y A+L L
Sbjct: 1399 QYQFIYKAMLSL 1410
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 180 bits (456), Expect = 5e-45
Identities = 100/245 (40%), Positives = 142/245 (57%), Gaps = 11/245 (4%)
Query: 49 AEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLST 108
A P N KNR +I+PY+ +RV L I E S YINA+FI G KAYIATQGPL+
Sbjct: 1257 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1316
Query: 109 TLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSD 168
T DFWRM+WE + I+VM EMG++KC +YW P E + F V AE
Sbjct: 1317 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYW--PAERSARYQYFVVDPMAEYNMPQ 1374
Query: 169 YIIRTLKV--KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPIC 224
YI+R KV + ++RT+ QF + +WP+ VP S + ++ I V +E PI
Sbjct: 1375 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1434
Query: 225 IHCSAGCGRTGVICAIDYTWMLLK-DGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVY 283
+HCSAG GRTGV + ++ +G++ +F ++ +RTQRP++VQT+++Y+ Y
Sbjct: 1435 VHCSAGVGRTGVFITLSIVLERMRYEGVV----DIFQTVKMLRTQRPAMVQTEDEYQFCY 1490
Query: 284 NAVLE 288
A LE
Sbjct: 1491 QAALE 1495
Score = 166 bits (421), Expect = 6e-41
Identities = 99/267 (37%), Positives = 138/267 (51%), Gaps = 9/267 (3%)
Query: 25 ANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSY 84
AN+ LKL ++ + + + N KNRY +++ YD+SRV L I S Y
Sbjct: 944 ANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY 1003
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
INAN++ G AYIATQGPL T DFWRM+WE IVM E + KC++YW
Sbjct: 1004 INANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW- 1062
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSI 202
P +G V+ + + +RT + N SE R + QF + WPDH VP
Sbjct: 1063 -PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYP 1121
Query: 203 DPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPE-NFSVFSL 261
P L + V+ D+ PI +HCSAG GRTG ID + + I PE V+
Sbjct: 1122 TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVID----AMLERIKPEKTVDVYGH 1177
Query: 262 IREMRTQRPSLVQTQEQYELVYNAVLE 288
+ MR+QR +VQT++QY ++ A+LE
Sbjct: 1178 VTLMRSQRNYMVQTEDQYSFIHEALLE 1204
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 180 bits (456), Expect = 5e-45
Identities = 100/245 (40%), Positives = 142/245 (57%), Gaps = 11/245 (4%)
Query: 49 AEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLST 108
A P N KNR +I+PY+ +RV L I E S YINA+FI G KAYIATQGPL+
Sbjct: 1662 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1721
Query: 109 TLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSD 168
T DFWRM+WE + I+VM EMG++KC +YW P E + F V AE
Sbjct: 1722 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYW--PAERSARYQYFVVDPMAEYNMPQ 1779
Query: 169 YIIRTLKV--KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPIC 224
YI+R KV + ++RT+ QF + +WP+ VP S + ++ I V +E PI
Sbjct: 1780 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1839
Query: 225 IHCSAGCGRTGVICAIDYTWMLLK-DGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVY 283
+HCSAG GRTGV + ++ +G++ +F ++ +RTQRP++VQT+++Y+ Y
Sbjct: 1840 VHCSAGVGRTGVFITLSIVLERMRYEGVV----DIFQTVKMLRTQRPAMVQTEDEYQFCY 1895
Query: 284 NAVLE 288
A LE
Sbjct: 1896 QAALE 1900
Score = 166 bits (421), Expect = 6e-41
Identities = 99/267 (37%), Positives = 138/267 (51%), Gaps = 9/267 (3%)
Query: 25 ANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSY 84
AN+ LKL ++ + + + N KNRY +++ YD+SRV L I S Y
Sbjct: 1349 ANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY 1408
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
INAN++ G AYIATQGPL T DFWRM+WE IVM E + KC++YW
Sbjct: 1409 INANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW- 1467
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSI 202
P +G V+ + + +RT + N SE R + QF + WPDH VP
Sbjct: 1468 -PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYP 1526
Query: 203 DPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPE-NFSVFSL 261
P L + V+ D+ PI +HCSAG GRTG ID + + I PE V+
Sbjct: 1527 TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVID----AMLERIKPEKTVDVYGH 1582
Query: 262 IREMRTQRPSLVQTQEQYELVYNAVLE 288
+ MR+QR +VQT++QY ++ A+LE
Sbjct: 1583 VTLMRSQRNYMVQTEDQYSFIHEALLE 1609
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 180 bits (456), Expect = 5e-45
Identities = 100/245 (40%), Positives = 142/245 (57%), Gaps = 11/245 (4%)
Query: 49 AEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLST 108
A P N KNR +I+PY+ +RV L I E S YINA+FI G KAYIATQGPL+
Sbjct: 1253 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1312
Query: 109 TLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSD 168
T DFWRM+WE + I+VM EMG++KC +YW P E + F V AE
Sbjct: 1313 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYW--PAERSARYQYFVVDPMAEYNMPQ 1370
Query: 169 YIIRTLKV--KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPIC 224
YI+R KV + ++RT+ QF + +WP+ VP S + ++ I V +E PI
Sbjct: 1371 YILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPIS 1430
Query: 225 IHCSAGCGRTGVICAIDYTWMLLK-DGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVY 283
+HCSAG GRTGV + ++ +G++ +F ++ +RTQRP++VQT+++Y+ Y
Sbjct: 1431 VHCSAGVGRTGVFITLSIVLERMRYEGVV----DIFQTVKMLRTQRPAMVQTEDEYQFCY 1486
Query: 284 NAVLE 288
A LE
Sbjct: 1487 QAALE 1491
Score = 166 bits (421), Expect = 6e-41
Identities = 99/267 (37%), Positives = 138/267 (51%), Gaps = 9/267 (3%)
Query: 25 ANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSY 84
AN+ LKL ++ + + + N KNRY +++ YD+SRV L I S Y
Sbjct: 940 ANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDY 999
Query: 85 INANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA 144
INAN++ G AYIATQGPL T DFWRM+WE IVM E + KC++YW
Sbjct: 1000 INANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW- 1058
Query: 145 EPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSI 202
P +G V+ + + +RT + N SE R + QF + WPDH VP
Sbjct: 1059 -PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYP 1117
Query: 203 DPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPE-NFSVFSL 261
P L + V+ D+ PI +HCSAG GRTG ID + + I PE V+
Sbjct: 1118 TPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVID----AMLERIKPEKTVDVYGH 1173
Query: 262 IREMRTQRPSLVQTQEQYELVYNAVLE 288
+ MR+QR +VQT++QY ++ A+LE
Sbjct: 1174 VTLMRSQRNYMVQTEDQYSFIHEALLE 1200
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.129 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,132,493
Number of Sequences: 37866
Number of extensions: 1494480
Number of successful extensions: 4960
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 101
Number of HSP's successfully gapped in prelim test: 71
Number of HSP's that attempted gapping in prelim test: 4357
Number of HSP's gapped (non-prelim): 293
length of query: 807
length of database: 18,247,518
effective HSP length: 110
effective length of query: 697
effective length of database: 14,082,258
effective search space: 9815333826
effective search space used: 9815333826
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.