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Search of human proteins with 223972651
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223972651 aldehyde dehydrogenase 16 family, member A1
isoform 1 [Homo sapiens]
(802 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform... 1623 0.0
gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform... 1478 0.0
gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens] 181 3e-45
gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens] 176 8e-44
gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Ho... 176 1e-43
gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens] 175 2e-43
gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens] 171 2e-42
gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo sap... 170 5e-42
gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens] 162 1e-39
gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens] 158 2e-38
gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo sa... 155 1e-37
gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens] 151 2e-36
gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens] 148 2e-35
gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo ... 146 7e-35
gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens] 138 2e-32
gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo... 137 4e-32
gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens] 105 2e-22
gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo sa... 100 7e-21
gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 64 4e-10
gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens] 64 4e-10
gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo... 64 4e-10
gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 50 8e-06
gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens] 50 8e-06
gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens] 46 1e-04
gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens] 46 1e-04
gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens] 46 1e-04
gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithora... 41 0.005
gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens] 38 0.033
gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens] 38 0.033
gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens] 37 0.073
>gi|223972651 aldehyde dehydrogenase 16 family, member A1 isoform 1
[Homo sapiens]
Length = 802
Score = 1623 bits (4202), Expect = 0.0
Identities = 802/802 (100%), Positives = 802/802 (100%)
Query: 1 MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ
Sbjct: 1 MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
Query: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW 120
DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW
Sbjct: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW 120
Query: 121 TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL 180
TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL
Sbjct: 121 TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL 180
Query: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ 240
EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ
Sbjct: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ 240
Query: 241 PGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWS 300
PGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWS
Sbjct: 241 PGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWS 300
Query: 301 DRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREA 360
DRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREA
Sbjct: 301 DRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREA 360
Query: 361 QSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN 420
QSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN
Sbjct: 361 QSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN 420
Query: 421 GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDG 480
GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDG
Sbjct: 421 GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDG 480
Query: 481 LYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPG 540
LYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPG
Sbjct: 481 LYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPG 540
Query: 541 ARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALE 600
ARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALE
Sbjct: 541 ARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALE 600
Query: 601 RRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREP 660
RRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREP
Sbjct: 601 RRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREP 660
Query: 661 LGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLAN 720
LGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLAN
Sbjct: 661 LGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLAN 720
Query: 721 VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAE 780
VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAE
Sbjct: 721 VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAE 780
Query: 781 GAGPELGLRVARTKALWLPMGD 802
GAGPELGLRVARTKALWLPMGD
Sbjct: 781 GAGPELGLRVARTKALWLPMGD 802
>gi|223972653 aldehyde dehydrogenase 16 family, member A1 isoform 2
[Homo sapiens]
Length = 751
Score = 1478 bits (3826), Expect = 0.0
Identities = 741/802 (92%), Positives = 743/802 (92%), Gaps = 51/802 (6%)
Query: 1 MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ
Sbjct: 1 MAATRAGPRAREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
Query: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW 120
DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW
Sbjct: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW 120
Query: 121 TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL 180
TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL
Sbjct: 121 TLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPMGVIGLILPPTFSFL 180
Query: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ 240
EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ
Sbjct: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQ 240
Query: 241 PGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWS 300
P G+ A+
Sbjct: 241 P---------------------------------------------------GIRKVAFC 249
Query: 301 DRGPGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREA 360
GGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREA
Sbjct: 250 GAPEGGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQRFVREA 309
Query: 361 QSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN 420
QSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN
Sbjct: 310 QSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVAN 369
Query: 421 GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDG 480
GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDG
Sbjct: 370 GTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDG 429
Query: 481 LYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPG 540
LYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPG
Sbjct: 430 LYEYLRPSGTPARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYGLFVGGRFQAPG 489
Query: 541 ARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALE 600
ARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALE
Sbjct: 490 ARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALE 549
Query: 601 RRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREP 660
RRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREP
Sbjct: 550 RRKSTLASRLERQGAELKAAEAEVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLREP 609
Query: 661 LGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLAN 720
LGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLAN
Sbjct: 610 LGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGLAN 669
Query: 721 VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAE 780
VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAE
Sbjct: 670 VVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRGCPRAWDQEAE 729
Query: 781 GAGPELGLRVARTKALWLPMGD 802
GAGPELGLRVARTKALWLPMGD
Sbjct: 730 GAGPELGLRVARTKALWLPMGD 751
>gi|25777724 aldehyde dehydrogenase 1A2 isoform 1 [Homo sapiens]
Length = 518
Score = 181 bits (458), Expect = 3e-45
Identities = 137/465 (29%), Positives = 219/465 (47%), Gaps = 25/465 (5%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
++N +W E P +P TGE + +A D+ AV+AAR+AF W
Sbjct: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
R + L +LA+++++ + +L T+ESL G+ + D+Q + Y+A
Sbjct: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
Query: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPL- 208
I EP+GV G I+P F L W+I PAL G TVV + PA PL
Sbjct: 161 TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVV--IKPAEQTPLS 218
Query: 209 --LLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLA-G 264
+ L E G PG++N+L G +AS GI K+AF G+ E G+ ++ +
Sbjct: 219 ALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRS 278
Query: 265 ECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMR 321
+ L LG +S ++ AD+D AVE + ++G G R+ ++ES+++E +R
Sbjct: 279 NLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVR 338
Query: 322 RLQERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFY 380
R ER R G D + G + + + ++ ++GA++ G + F+
Sbjct: 339 RSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFF 398
Query: 381 -PPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQAL 439
PT+ SN+ A+ E+ PV F+T E + AN + G A+V++ + +AL
Sbjct: 399 IEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKAL 458
Query: 440 ELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 484
+ +Q GTVWIN + + P GG K SG G GL EY
Sbjct: 459 TVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREY 503
Score = 79.7 bits (195), Expect = 1e-14
Identities = 82/278 (29%), Positives = 118/278 (42%), Gaps = 19/278 (6%)
Query: 509 AVPSTLPAGPEIGPSPAPPYGL-----FVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGG 562
A P+ L A + PSP P + F+ +Q + P+ + ++G V E
Sbjct: 14 ADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEAD 73
Query: 563 AKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKA 619
DI AV+AA AF W R LL LA +ER ++ LA+ G +
Sbjct: 74 KADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFL 133
Query: 620 AEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPL 674
V+L R W ++ G T+ V G R EP+GV + P +PL
Sbjct: 134 QAFYVDLQGVIKTFRYYAGWADKIH--GMTIPVDGDYFTFTR-HEPIGVCGQIIPWNFPL 190
Query: 675 LAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDHLTRCL 733
L F +APAL GNTVV+ P+ PL AL + + FP G+ N++ G +
Sbjct: 191 LMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVINILPGYGPTAGAAI 250
Query: 734 ALHQDVQAMWYFGSAQ-GSQFVEWASAGNLKPVWASRG 770
A H + + + GS + G E A NLK V G
Sbjct: 251 ASHIGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELG 288
>gi|25777730 aldehyde dehydrogenase 1B1 precursor [Homo sapiens]
Length = 517
Score = 176 bits (446), Expect = 8e-44
Identities = 133/463 (28%), Positives = 221/463 (47%), Gaps = 21/463 (4%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
++N +W + + P +P TGE + + DV AV+AAR AF+ W
Sbjct: 40 FINNEWQDAVSKKTFPTVNPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDAS 99
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
R + L RLA+++++ + L +LE+L G+ +E D+ ++ Y A
Sbjct: 100 ERGRLLNRLADLVERDRVYLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGK 159
Query: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASP-APL 208
I Q EP+GV G I+P F + W++ PALA G TVV V +P + L
Sbjct: 160 TIPMDGQHFCFTRHEPVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSAL 219
Query: 209 LLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLA-GEC 266
LA L E G PG++N+++G +A + KVAF G+ E G ++++
Sbjct: 220 YLASLIKEAGFPPGVVNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNL 279
Query: 267 AELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMRRL 323
+ L LG +S ++ AD++ AVE +A + + G G R ++ES+++E + R
Sbjct: 280 KRVTLELGGKSPSIVLADADMEHAVEQCHEALFFNMGQCCCAGSRTFVEESIYNEFLERT 339
Query: 324 QERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFY-P 381
E+ + + G + G + + V +++ Q +GA++ G+ ER F+
Sbjct: 340 VEKAKQRKVGNPFELDTQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGFFIK 399
Query: 382 PTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALEL 441
PT+ + A+ E+ PV F+ +E + AN T G +A+V++ L +A+
Sbjct: 400 PTVFGGVQDDMRIAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYF 459
Query: 442 GYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 484
LQ GTVW+N + + P GG KESG G DGL Y
Sbjct: 460 TQALQAGTVWVNTYNIVTCHTPFGGFKESGNGRELGEDGLKAY 502
Score = 88.2 bits (217), Expect = 3e-17
Identities = 92/293 (31%), Positives = 134/293 (45%), Gaps = 25/293 (8%)
Query: 491 PARLSCLSKNLNYDTFGLAVPSTLPAGPEIGPSPAPPYG-LFVGGRFQAPGARSSRP-IR 548
P LS + Y + A+PS + P+I PY LF+ +Q ++ + P +
Sbjct: 7 PRLLSLQGRTARYSS-AAALPSPI-LNPDI------PYNQLFINNEWQDAVSKKTFPTVN 58
Query: 549 DSSGNLHGYVAEGGAKDIRGAVEAAHQAF---PGWAGQSPGARAALLWALAAALERRKST 605
++G + G+VAEG D+ AV+AA +AF W R LL LA +ER +
Sbjct: 59 PTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRVY 118
Query: 606 LASRLER--QGAELKAAEA----EVELSARRLRAWGARVQAQGHTLQVAGLRGPVLRLRE 659
LAS LE G + + A EV R W + G T+ + G R E
Sbjct: 119 LAS-LETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWH--GKTIPMDGQHFCFTR-HE 174
Query: 660 PLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGL 718
P+GV + P +PL+ LAPALA GNTVVM + PL AL + + FP G+
Sbjct: 175 PVGVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGV 234
Query: 719 ANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASA-GNLKPVWASRG 770
N++TG +A H DV + + GS + ++ A+ NLK V G
Sbjct: 235 VNIITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELG 287
>gi|25777732 mitochondrial aldehyde dehydrogenase 2 precursor [Homo
sapiens]
Length = 517
Score = 176 bits (445), Expect = 1e-43
Identities = 144/505 (28%), Positives = 233/505 (46%), Gaps = 28/505 (5%)
Query: 2 AATRAGPR-AREIFTSLEYGPVPESHACALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQ 60
AA R GPR R + ++ VP + + C ++N +W R + P
Sbjct: 4 AAARFGPRLGRRLLSAAATQAVPAPNQ------QPEVFCNQIFINNEWHDAVSRKTFPTV 57
Query: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGVVRAQHLTRLAEVIQKHQR 117
+P TGE + + EDV AV+AAR AF+ W R + L RLA++I++ +
Sbjct: 58 NPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDASHRGRLLNRLADLIERDRT 117
Query: 118 LLWTLESLVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEE----------ALAGWEPMG 167
L LE+L G+ D+ + + L Y+A A + EP+G
Sbjct: 118 YLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVG 177
Query: 168 VIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASP-APLLLAQLAGELGPFPGILNV 226
V G I+P F L W++ PALA G VV V +P L +A L E G PG++N+
Sbjct: 178 VCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNI 237
Query: 227 LSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSL-AGECAELGLALGTESLLLLTDT 284
+ G +AS + KVAF G+ E GR ++ + + + L LG +S ++
Sbjct: 238 VPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSSNLKRVTLELGGKSPNIIMSD 297
Query: 285 ADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVD 341
AD+D AVE A + ++G G R +QE ++DE + R R G D +
Sbjct: 298 ADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDIYDEFVERSVARAKSRVVGNPFDSKTE 357
Query: 342 MGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFY-PPTLVSNLPPASPCAQVEV 399
G + + ++ + +GA++ G + ++R ++ PT+ ++ A+ E+
Sbjct: 358 QGPQVDETQFKKILGYINTGKQEGAKLLCGGGIAADRGYFIQPTVFGDVQDGMTIAKEEI 417
Query: 400 PWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLRD 459
PV+ F+T +E + AN + G +A+V+++ L +A L LQ GTVW+N + +
Sbjct: 418 FGPVMQILKFKTIEEVVGRANNSTYGLAAAVFTKDLDKANYLSQALQAGTVWVNCYDVFG 477
Query: 460 PSVPTGGCKESGCSWHGGPDGLYEY 484
P GG K SG G GL Y
Sbjct: 478 AQSPFGGYKMSGSGRELGEYGLQAY 502
Score = 81.6 bits (200), Expect = 3e-15
Identities = 75/250 (30%), Positives = 119/250 (47%), Gaps = 10/250 (4%)
Query: 530 LFVGGRFQAPGARSSRP-IRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFP---GWAGQSP 585
+F+ + +R + P + S+G + VAEG +D+ AV+AA AF W
Sbjct: 39 IFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGDKEDVDKAVKAARAAFQLGSPWRRMDA 98
Query: 586 GARAALLWALAAALERRKSTLAS--RLERQGAELKAAEAEVELSARRLRAW-GARVQAQG 642
R LL LA +ER ++ LA+ L+ + + ++++ + LR + G + G
Sbjct: 99 SHRGRLLNRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHG 158
Query: 643 HTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLL 702
T+ + G R EP+GV + P +PLL L PALA GN VVM + PL
Sbjct: 159 KTIPIDGDFFSYTR-HEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLT 217
Query: 703 ALEVCQDMATV-FPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWAS-AG 760
AL V + FP G+ N+V G +A H+DV + + GS + + ++ A+ +
Sbjct: 218 ALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEIGRVIQVAAGSS 277
Query: 761 NLKPVWASRG 770
NLK V G
Sbjct: 278 NLKRVTLELG 287
>gi|21361176 aldehyde dehydrogenase 1A1 [Homo sapiens]
Length = 501
Score = 175 bits (443), Expect = 2e-43
Identities = 141/477 (29%), Positives = 225/477 (47%), Gaps = 27/477 (5%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
++N +W P +P T E L + EDV AV+AAR AF+ W
Sbjct: 24 FINNEWHDSVSGKKFPVFNPATEEELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDAS 83
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAS 154
R + L +LA++I++ + LL T+ES+ G+ D+ + L Y A IQ
Sbjct: 84 ERGRLLYKLADLIERDRLLLATMESMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGR 143
Query: 155 T-----QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLL 209
T EP+GV G I+P F + ++W+I PAL+ G TVV V PA PL
Sbjct: 144 TIPIDGNFFTYTRHEPIGVCGQIIPWNFPLVMLIWKIGPALSCGNTVV--VKPAEQTPLT 201
Query: 210 ---LAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLA-G 264
+A L E G PG++N++ G ++S I KVAF G+ E G+ ++ +
Sbjct: 202 ALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKS 261
Query: 265 ECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMR 321
+ L LG +S ++ AD+D+AVE + +G R+ ++ES++DE +R
Sbjct: 262 NLKRVTLELGGKSPCIVLADADLDNAVEFAHHGVFYHQGQCCIAASRIFVEESIYDEFVR 321
Query: 322 RLQERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVP--SERP 378
R ER + G L V G + D + + + +GA++ + G P ++
Sbjct: 322 RSVERAKKYILGNPLTPGVTQGPQIDKEQYDKILDLIESGKKEGAKL-ECGGGPWGNKGY 380
Query: 379 FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQA 438
F PT+ SN+ A+ E+ PV F++ + + AN T G SA V+++ + +A
Sbjct: 381 FVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKA 440
Query: 439 LELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLS 495
+ + LQ GTVW+N +G+ P GG K SG G G +EY ++S
Sbjct: 441 ITISSALQAGTVWVNCYGVVSAQCPFGGFKMSGNGRELGEYGFHEYTEVKTVTVKIS 497
Score = 89.0 bits (219), Expect = 2e-17
Identities = 70/223 (31%), Positives = 103/223 (46%), Gaps = 13/223 (5%)
Query: 558 VAEGGAKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQG 614
V EG +D+ AV+AA QAF W R LL+ LA +ER + LA+ G
Sbjct: 52 VEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATMESMNG 111
Query: 615 AELKAAEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCP 669
+L + +L+ R W ++Q G T+ + G R EP+GV + P
Sbjct: 112 GKLYSNAYLNDLAGCIKTLRYCAGWADKIQ--GRTIPIDGNFFTYTR-HEPIGVCGQIIP 168
Query: 670 DEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDH 728
+PL+ + + PAL+ GNTVV+ P+ PL AL V + FP G+ N+V G
Sbjct: 169 WNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPT 228
Query: 729 LTRCLALHQDVQAMWYFGSAQ-GSQFVEWASAGNLKPVWASRG 770
++ H D+ + + GS + G E A NLK V G
Sbjct: 229 AGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELG 271
>gi|12007648 aldehyde dehydrogenase 8A1 isoform 1 [Homo sapiens]
Length = 487
Score = 171 bits (434), Expect = 2e-42
Identities = 127/465 (27%), Positives = 225/465 (48%), Gaps = 27/465 (5%)
Query: 40 LGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGV 99
L ++++GK+L + + DP TGE + +++ AAV+AAR AF WS+
Sbjct: 10 LENFIDGKFLPCS--SYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQ 67
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHY------HAIQA 153
R++ L ++A+++++ ES G+ + R D+ + Q + H
Sbjct: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSE 127
Query: 154 STQEEALAGWE-----PMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPP-ASPAP 207
TQ + L P+GV GLI P + W+I PA+A G TV+A S
Sbjct: 128 CTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTA 187
Query: 208 LLLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLAGEC 266
+L +L + G PG++N++ G V L S P + ++F G+ + + A C
Sbjct: 188 WMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHC 247
Query: 267 AELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGL---RLLIQESVWDEAMRRL 323
+L L LG ++ ++ + A++D + V ++++++G L R+ +Q+S++ E ++R
Sbjct: 248 KKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRF 307
Query: 324 QERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDV-----PSER 377
E + + G D V +GA A + V+ +V+ A ++GAQ++ V P+
Sbjct: 308 VEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARN 367
Query: 378 P---FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSER 434
F PT+++++ S C E+ PV PF + +E + AN G +A+VWS
Sbjct: 368 QAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSN 427
Query: 435 LGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPD 479
+G+ + LQ G VW N +R+ ++P GG K SG G D
Sbjct: 428 VGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKD 472
Score = 83.6 bits (205), Expect = 7e-16
Identities = 68/238 (28%), Positives = 112/238 (47%), Gaps = 7/238 (2%)
Query: 531 FVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAA 590
F+ G+F P + S+G ++ V G +I AV+AA +AFP W+ +SP R+
Sbjct: 13 FIDGKF-LPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSR 71
Query: 591 LLWALAAALERRKSTLA-SRLERQGAELKAAEA-EVELSARRLRAW-GARVQAQGHTLQV 647
+L +A LE+ A + + QG L A ++ S + R + + + Q+
Sbjct: 72 VLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQM 131
Query: 648 AGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVC 707
L +R P+GV ++ P PL +APA+A GNTV+ PS + A +C
Sbjct: 132 DHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLC 191
Query: 708 Q--DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLK 763
+ D A V P G+ N+V G + L H +V + + GS ++ + SA + K
Sbjct: 192 KLLDKAGV-PPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCK 248
>gi|21614513 aldehyde dehydrogenase 1 family, member L1 [Homo
sapiens]
Length = 902
Score = 170 bits (430), Expect = 5e-42
Identities = 138/472 (29%), Positives = 231/472 (48%), Gaps = 30/472 (6%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKG--WSAHPGVV 100
++ G+++ E + +P G + AQ DV AV AA+ AF+ W
Sbjct: 425 FIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKISARD 484
Query: 101 RAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAST 155
R + + RLA+++++HQ L T+E+L G V ++ Q Y A IQ ST
Sbjct: 485 RGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKIQGST 544
Query: 156 ---------QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPA 206
+ L EP+GV G+I+P + + + W+ LA G TVV + PA
Sbjct: 545 IPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVV--IKPAQVT 602
Query: 207 PLL---LAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSL 262
PL A+L + G G++NVL G SLV L+ P +RK+ F G+ E G+ + +S
Sbjct: 603 PLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSC 662
Query: 263 A-GECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGL---RLLIQESVWDE 318
A ++ L LG +S L++ D++ AV+ + + + ++G + RL +++S+ DE
Sbjct: 663 AISNVKKVSLELGGKSPLIIFADCDLNKAVQMGMSSVFFNKGENCIAAGRLFVEDSIHDE 722
Query: 319 AMRRLQERMGRLRSGRGLDGAVDMGARGAAACDL-VQRFVREAQSQGAQVFQAGD-VPSE 376
+RR+ E + +++ G LD D G + A + + + + +GA + G+ VP
Sbjct: 723 FVRRVVEEVRKMKVGNPLDRDTDHGPQNHHAHLVKLMEYCQHGVKEGATLVCGGNQVPRP 782
Query: 377 RPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAK--EALLVANGTPRGGSASVWSER 434
F+ PT+ +++ A+ E PV++ S F L AN T G ++ V++
Sbjct: 783 GFFFEPTVFTDVEDHMFIAKEESFGPVMIISRFADGDLDAVLSRANATEFGLASGVFTRD 842
Query: 435 LGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLR 486
+ +AL + LQ GTV++N + D + P GG K+SG G L EYLR
Sbjct: 843 INKALYVSDKLQAGTVFVNTYNKTDVAAPFGGFKQSGFGKDLGEAALNEYLR 894
Score = 94.0 bits (232), Expect = 5e-19
Identities = 76/250 (30%), Positives = 122/250 (48%), Gaps = 11/250 (4%)
Query: 527 PYGLFVGGRF-QAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPG--WAGQ 583
P+ LF+GG F A GA++S I + G++ V+ D+ AV AA AF W
Sbjct: 421 PHQLFIGGEFVDAEGAKTSETINPTDGSVICQVSLAQVTDVDKAVAAAKDAFENGRWGKI 480
Query: 584 SPGARAALLWALAAALERRKSTLAS--RLERQGAELKAAEAEVELSARRLRAW-GARVQA 640
S R L++ LA +E+ + LA+ L+ A + V +S + R + G +
Sbjct: 481 SARDRGRLMYRLADLMEQHQEELATIEALDAGAVYTLALKTHVGMSIQTFRYFAGWCDKI 540
Query: 641 QGHTL---QVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSA 697
QG T+ Q R L +EP+GV ++ P +PL+ A LA GNTVV+ P+
Sbjct: 541 QGSTIPINQARPNRNLTLTRKEPVGVCGIIIPWNYPLMMLSWKTAACLAAGNTVVIKPAQ 600
Query: 698 ACPLLALEVCQ-DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQ-GSQFVE 755
PL AL+ + + P G+ NV+ G + + L+ H DV+ + + GS + G ++
Sbjct: 601 VTPLTALKFAELTLKAGIPKGVVNVLPGSGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMK 660
Query: 756 WASAGNLKPV 765
+ N+K V
Sbjct: 661 SCAISNVKKV 670
>gi|153266822 aldehyde dehydrogenase 1A3 [Homo sapiens]
Length = 512
Score = 162 bits (410), Expect = 1e-39
Identities = 130/465 (27%), Positives = 218/465 (46%), Gaps = 25/465 (5%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKG---WSAHPGV 99
++N +W + + +P T E + + DV AVEAA++AF+ W +
Sbjct: 35 FINNEWHESKSGKKFATCNPSTREQICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDAL 94
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAS 154
R + L +LA+++++ + L LE++ TG+ D++ + L Y A IQ
Sbjct: 95 SRGRLLHQLADLVERDRATLAALETMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGK 154
Query: 155 T-----QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLL 209
T EP+GV G I P F L ++W++ PAL G T+V + PA PL
Sbjct: 155 TIPTDDNVVCFTRHEPIGVCGAITPWNFPLLMLVWKLAPALCCGNTMV--LKPAEQTPLT 212
Query: 210 ---LAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLA-G 264
L L E G PG++N++ G V ++S P I K+AF G+ E G+ ++ + +
Sbjct: 213 ALYLGSLIKEAGFPPGVVNIVPGFGPTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRS 272
Query: 265 ECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMR 321
+ L LG ++ ++ AD+D AVE + ++G R+ ++E V+ E +R
Sbjct: 273 NLKRVTLELGGKNPCIVCADADLDLAVECAHQGVFFNQGQCCTAASRVFVEEQVYSEFVR 332
Query: 322 RLQERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERP-F 379
R E + G D + G + D + + + +GA++ G ++ F
Sbjct: 333 RSVEYAKKRPVGDPFDVKTEQGPQIDQKQFDKILELIESGKKEGAKLECGGSAMEDKGLF 392
Query: 380 YPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQAL 439
PT+ S + A+ E+ PV F++ +E + AN T G +A+V+++ L +AL
Sbjct: 393 IKPTVFSEVTDNMRIAKEEIFGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKAL 452
Query: 440 ELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 484
+L L+ GTVWIN + P GG K SG G L EY
Sbjct: 453 KLASALESGTVWINCYNALYAQAPFGGFKMSGNGRELGEYALAEY 497
Score = 80.9 bits (198), Expect = 4e-15
Identities = 74/223 (33%), Positives = 105/223 (47%), Gaps = 13/223 (5%)
Query: 558 VAEGGAKDIRGAVEAAHQAFPG---WAGQSPGARAALLWALAAALERRKSTLAS--RLER 612
V EG D+ AVEAA AF W +R LL LA +ER ++TLA+ ++
Sbjct: 63 VEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALETMDT 122
Query: 613 QGAELKAAEAEVELSARRLR---AWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCP 669
L A ++E R LR W ++Q G T+ R EP+GV + P
Sbjct: 123 GKPFLHAFFIDLEGCIRTLRYFAGWADKIQ--GKTIPTDDNVVCFTR-HEPIGVCGAITP 179
Query: 670 DEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDH 728
+PLL V LAPAL GNT+V+ P+ PL AL + + FP G+ N+V G
Sbjct: 180 WNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFGPT 239
Query: 729 LTRCLALHQDVQAMWYFGSAQGSQFV-EWASAGNLKPVWASRG 770
+ ++ H + + + GS + + V E AS NLK V G
Sbjct: 240 VGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELG 282
>gi|115387104 aldehyde dehydrogenase 9A1 [Homo sapiens]
Length = 518
Score = 158 bits (399), Expect = 2e-38
Identities = 129/439 (29%), Positives = 215/439 (48%), Gaps = 23/439 (5%)
Query: 61 DPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW 120
+P TG +A+ + ++V AV+ A+ AFK WS G+ R + L A +I++ + +
Sbjct: 57 EPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIA 116
Query: 121 TLESLVTGRAVREVRDGDVQLAQQLLHYHA-IQASTQEEALA------GW---EPMGVIG 170
T+E + G+++ E R D+ ++ Q L Y+A + AS E + G+ EP+GV
Sbjct: 117 TMECINNGKSIFEARL-DIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCV 175
Query: 171 LILPPTFSFLEMMWRICPALAVGCTVVALVPPASP-APLLLAQLAGELGPFPGILNVLSG 229
I + F W+ PALA G +V P +P + LLLA++ E G PG+ NV+ G
Sbjct: 176 GIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQG 235
Query: 230 PASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDS 289
A+ L P + KV+F G+ G + A + L LG +S L++ D+++
Sbjct: 236 GAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNN 295
Query: 290 AVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGAR- 345
AV+G + A + +G G R+ +Q+ + D+ + ++ R++ G L MG
Sbjct: 296 AVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLI 355
Query: 346 GAAACDLVQRFVREAQSQGAQVFQAGDV-PSERP------FYPPTLVSNLPPASPCAQVE 398
+ V FV+ A+ QGA+V GD+ E P + P +++N C + E
Sbjct: 356 NRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEE 415
Query: 399 VPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGLR 458
+ PV+ F T E L AN T G +A V++ + +A + LQ GT +IN + +
Sbjct: 416 IFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVS 475
Query: 459 DPSVPTGGCKESGCSWHGG 477
+P GG K+SG G
Sbjct: 476 PVELPFGGYKKSGFGRENG 494
Score = 68.9 bits (167), Expect = 2e-11
Identities = 76/277 (27%), Positives = 114/277 (41%), Gaps = 15/277 (5%)
Query: 507 GLAVPSTLPAGPEIGPSPAPPYGLFV---------GGRFQ-APGARSSRPIRDSSGNLHG 556
GLA S L P A G FV G R + A + + + ++G +
Sbjct: 6 GLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIA 65
Query: 557 YVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLAS-RLERQGA 615
G K++ AV+ A AF W+ +S R +L A + R+ +A+ G
Sbjct: 66 TFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGK 125
Query: 616 ELKAAEAEVELSARRLRAW-GARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPL 674
+ A ++++S + L + G G +Q+ G R REPLGV + +P
Sbjct: 126 SIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTR-REPLGVCVGIGAWNYPF 184
Query: 675 LAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDRDHLTRCL 733
APALA GN +V PS P+ AL + + + P GL NVV G + L
Sbjct: 185 QIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGA-ATGQFL 243
Query: 734 ALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 770
H DV + + GS + SA +KPV G
Sbjct: 244 CQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELG 280
>gi|238814322 aldehyde dehydrogenase 1 family, member L2 [Homo
sapiens]
Length = 923
Score = 155 bits (392), Expect = 1e-37
Identities = 126/473 (26%), Positives = 228/473 (48%), Gaps = 32/473 (6%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKG--WSAHPGVV 100
++NG++ + + +P G + A DV AV AA+ AF+ W
Sbjct: 446 FINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARE 505
Query: 101 RAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA-----IQAST 155
R + + RLA++++++Q L T+E+L +G + ++ Q Y A IQ ST
Sbjct: 506 RGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGST 565
Query: 156 ---------QEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPA 206
+ EP+GV +I+P + + + W+ LA G T+V + PA
Sbjct: 566 IPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLV--LKPAQVT 623
Query: 207 PLL---LAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSL 262
PL A+L+ + G G++N++ G + L+ P IRK+ F G+ G+ + +S
Sbjct: 624 PLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSC 683
Query: 263 A-GECAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGL---RLLIQESVWDE 318
A ++ L LG +S L++ + ++D AV + A + ++G + RL ++ES+ DE
Sbjct: 684 AVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDE 743
Query: 319 AMRRLQERMGRLRSGRGLDGAVDMGARGAAA-CDLVQRFVREAQSQGAQVFQAGDVPSER 377
+ R+ E + +++ G LD + D G + A + + ++ +GA + G +R
Sbjct: 744 FVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGR-QVQR 802
Query: 378 P--FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAK--EALLVANGTPRGGSASVWSE 433
P F PT+ +++ A+ E P++V S F+ L AN T G ++ V++
Sbjct: 803 PGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTR 862
Query: 434 RLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLR 486
+ +A+ + L+ GTV+IN + D + P GG K+SG G + L EYL+
Sbjct: 863 DINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLK 915
Score = 89.7 bits (221), Expect = 9e-18
Identities = 72/250 (28%), Positives = 116/250 (46%), Gaps = 11/250 (4%)
Query: 527 PYGLFVGGRF-QAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPG--WAGQ 583
PY F+ G+F A ++ I + G+ V+ D+ AV AA AF W
Sbjct: 442 PYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRM 501
Query: 584 SPGARAALLWALAAALERRKSTLAS--RLERQGAELKAAEAEVELSARRLRAW-GARVQA 640
+ R L++ LA LE + LA+ L+ A + + +S + R + G +
Sbjct: 502 NARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKI 561
Query: 641 QGHTL---QVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSA 697
QG T+ Q R +EPLGV A++ P +PL+ A LA GNT+V+ P+
Sbjct: 562 QGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQ 621
Query: 698 ACPLLALEVCQ-DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQ-GSQFVE 755
PL AL+ + + FP G+ N++ G + L+ H D++ + + GS G Q ++
Sbjct: 622 VTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMK 681
Query: 756 WASAGNLKPV 765
+ NLK V
Sbjct: 682 SCAVSNLKKV 691
>gi|25777728 aldehyde dehydrogenase 1A2 isoform 3 [Homo sapiens]
Length = 422
Score = 151 bits (382), Expect = 2e-36
Identities = 119/404 (29%), Positives = 192/404 (47%), Gaps = 22/404 (5%)
Query: 101 RAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA---------- 150
R + L +LA+++++ + +L T+ESL G+ + D+Q + Y+A
Sbjct: 6 RGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGMT 65
Query: 151 IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPL-- 208
I EP+GV G I+P F L W+I PAL G TVV + PA PL
Sbjct: 66 IPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVV--IKPAEQTPLSA 123
Query: 209 -LLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLA-GE 265
+ L E G PG++N+L G +AS GI K+AF G+ E G+ ++ +
Sbjct: 124 LYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRSN 183
Query: 266 CAELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMRR 322
+ L LG +S ++ AD+D AVE + ++G G R+ ++ES+++E +RR
Sbjct: 184 LKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRR 243
Query: 323 LQERMGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFY- 380
ER R G D + G + + + ++ ++GA++ G + F+
Sbjct: 244 SVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFI 303
Query: 381 PPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALE 440
PT+ SN+ A+ E+ PV F+T E + AN + G A+V++ + +AL
Sbjct: 304 EPTVFSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALT 363
Query: 441 LGYGLQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 484
+ +Q GTVWIN + + P GG K SG G GL EY
Sbjct: 364 VSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREY 407
Score = 64.7 bits (156), Expect = 3e-10
Identities = 59/190 (31%), Positives = 84/190 (44%), Gaps = 10/190 (5%)
Query: 588 RAALLWALAAALERRKSTLASRLERQGAELKAAEAEVELSA-----RRLRAWGARVQAQG 642
R LL LA +ER ++ LA+ G + V+L R W ++ G
Sbjct: 6 RGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIH--G 63
Query: 643 HTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLL 702
T+ V G R EP+GV + P +PLL F +APAL GNTVV+ P+ PL
Sbjct: 64 MTIPVDGDYFTFTR-HEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLS 122
Query: 703 ALEVCQDMATV-FPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQ-GSQFVEWASAG 760
AL + + FP G+ N++ G +A H + + + GS + G E A
Sbjct: 123 ALYMGALIKEAGFPPGVINILPGYGPTAGAAIASHIGIDKIAFTGSTEVGKLIQEAAGRS 182
Query: 761 NLKPVWASRG 770
NLK V G
Sbjct: 183 NLKRVTLELG 192
>gi|25777726 aldehyde dehydrogenase 1A2 isoform 2 [Homo sapiens]
Length = 480
Score = 148 bits (373), Expect = 2e-35
Identities = 122/460 (26%), Positives = 200/460 (43%), Gaps = 53/460 (11%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFK---GWSAHPGV 99
++N +W E P +P TGE + +A D+ AV+AAR+AF W
Sbjct: 41 FINNEWQNSESGRVFPVYNPATGEQVCEVQEADKADIDKAVQAARLAFSLGSVWRRMDAS 100
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA--------- 150
R + L +LA+++++ + +L T+ESL G+ + D+Q + Y+A
Sbjct: 101 ERGRLLDKLADLVERDRAVLATMESLNGGKPFLQAFYVDLQGVIKTFRYYAGWADKIHGM 160
Query: 151 -IQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAPLL 209
I EP+GV G I+P F L W+I PAL G TVV + PA PL
Sbjct: 161 TIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVV--IKPAEQTPLS 218
Query: 210 LAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAEL 269
+ ++ L+ A + +++V
Sbjct: 219 ALYMGA----------LIKEVGKLIQEAAGRSNLKRVT---------------------- 246
Query: 270 GLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGP---GGLRLLIQESVWDEAMRRLQER 326
L LG +S ++ AD+D AVE + ++G G R+ ++ES+++E +RR ER
Sbjct: 247 -LELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIFVEESIYEEFVRRSVER 305
Query: 327 MGRLRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFY-PPTL 384
R G D + G + + + ++ ++GA++ G + F+ PT+
Sbjct: 306 AKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGVAEGAKLECGGKGLGRKGFFIEPTV 365
Query: 385 VSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYG 444
SN+ A+ E+ PV F+T E + AN + G A+V++ + +AL +
Sbjct: 366 FSNVTDDMRIAKEEIFGPVQEILRFKTMDEVIERANNSDFGLVAAVFTNDINKALTVSSA 425
Query: 445 LQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEY 484
+Q GTVWIN + + P GG K SG G GL EY
Sbjct: 426 MQAGTVWINCYNALNAQSPFGGFKMSGNGREMGEFGLREY 465
Score = 67.0 bits (162), Expect = 7e-11
Identities = 65/210 (30%), Positives = 91/210 (43%), Gaps = 17/210 (8%)
Query: 509 AVPSTLPAGPEIGPSPAPPYGL-----FVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGG 562
A P+ L A + PSP P + F+ +Q + P+ + ++G V E
Sbjct: 14 ADPAALMASLHLLPSPTPNLEIKYTKIFINNEWQNSESGRVFPVYNPATGEQVCEVQEAD 73
Query: 563 AKDIRGAVEAAHQAFP---GWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKA 619
DI AV+AA AF W R LL LA +ER ++ LA+ G +
Sbjct: 74 KADIDKAVQAARLAFSLGSVWRRMDASERGRLLDKLADLVERDRAVLATMESLNGGKPFL 133
Query: 620 AEAEVELSA-----RRLRAWGARVQAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPL 674
V+L R W ++ G T+ V G R EP+GV + P +PL
Sbjct: 134 QAFYVDLQGVIKTFRYYAGWADKIH--GMTIPVDGDYFTFTR-HEPIGVCGQIIPWNFPL 190
Query: 675 LAFVSLLAPALAYGNTVVMVPSAACPLLAL 704
L F +APAL GNTVV+ P+ PL AL
Sbjct: 191 LMFAWKIAPALCCGNTVVIKPAEQTPLSAL 220
>gi|4507229 aldehyde dehydrogenase 5A1 isoform 2 precursor [Homo
sapiens]
Length = 535
Score = 146 bits (369), Expect = 7e-35
Identities = 134/508 (26%), Positives = 220/508 (43%), Gaps = 32/508 (6%)
Query: 5 RAGPRAREIFTSLEYGPVPESHAC---ALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQD 61
R PRA + + P P C LA L +V G+WL + P QD
Sbjct: 23 RLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAA--TFPVQD 80
Query: 62 PITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWT 121
P +G L + AAV AA AF W R+ L + ++ +++ L
Sbjct: 81 PASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLAR 140
Query: 122 LESLVTGRAVREVRDGDVQLAQQLLHYHAIQA-----------STQEEALAGWEPMGVIG 170
+ + +G+ ++E G++ + L + + +A + AL +P+GV
Sbjct: 141 IITAESGKPLKEAH-GEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAA 199
Query: 171 LILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP---LLLAQLAGELGPFPGILNVL 227
+I P F + ++ ALA GCTVV V PA P L LA+LA + G G+ NV+
Sbjct: 200 VITPWNFPSAMITRKVGAALAAGCTVV--VKPAEDTPFSALALAELASQAGIPSGVYNVI 257
Query: 228 ----SGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTD 283
+ + + P + K++F G+ G+ L A + + LG + ++ D
Sbjct: 258 PCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVSMELGGLAPFIVFD 317
Query: 284 TADVDSAVEGVVDAAWSDRGPGGL---RLLIQESVWDEAMRRLQERMGR-LRSGRGLDGA 339
+A+VD AV G + + + + G + + L+Q + D ++ E M + LR G G +
Sbjct: 318 SANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAMKKNLRVGNGFEEG 377
Query: 340 VDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPS-ERPFYPPTLVSNLPPASPCAQV 397
G A + V++ V +A S+GA V G + F+ PTL+ N+ C
Sbjct: 378 TTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTLLCNVTQDMLCTHE 437
Query: 398 EVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQVGTVWINAHGL 457
E P+ F T +EA+ +AN G + +S+ Q + L+VG V +N +
Sbjct: 438 ETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQLEVGMVGVNEGLI 497
Query: 458 RDPSVPTGGCKESGCSWHGGPDGLYEYL 485
P GG K+SG G G+ EYL
Sbjct: 498 SSVECPFGGVKQSGLGREGSKYGIDEYL 525
Score = 77.4 bits (189), Expect = 5e-14
Identities = 78/281 (27%), Positives = 121/281 (43%), Gaps = 28/281 (9%)
Query: 450 VWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLA 509
+W+ + G R G GC GL P+ PA+L C + L + L
Sbjct: 5 IWLRSCGARRL-----GSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALL 59
Query: 510 VPSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGGAKDIRG 568
+ FVGGR+ A ++ P++D +SG G VA+ G ++ R
Sbjct: 60 RTDS-----------------FVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARA 100
Query: 569 AVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQ-GAELKAAEAEVELS 627
AV AA++AF W S R++LL + + K LA + + G LK A E+ S
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYS 160
Query: 628 ARRLRAWGARVQ-AQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALA 686
A L + + G + L L++P+GV AV+ P +P + ALA
Sbjct: 161 AFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALA 220
Query: 687 YGNTVVMVPSAACPLLALEVCQDMATV-FPAGLANVVTGDR 726
G TVV+ P+ P AL + + + P+G+ NV+ R
Sbjct: 221 AGCTVVVKPAEDTPFSALALAELASQAGIPSGVYNVIPCSR 261
>gi|25952152 aldehyde dehydrogenase 8A1 isoform 2 [Homo sapiens]
Length = 433
Score = 138 bits (347), Expect = 2e-32
Identities = 115/453 (25%), Positives = 205/453 (45%), Gaps = 57/453 (12%)
Query: 40 LGHYVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGV 99
L ++++GK+L + + DP TGE + +++ AAV+AAR AF WS+
Sbjct: 10 LENFIDGKFLPCS--SYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQ 67
Query: 100 VRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHY------HAIQA 153
R++ L ++A+++++ ES G+ + R D+ + Q + H
Sbjct: 68 ERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSE 127
Query: 154 STQEEALAGWE-----PMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPP-ASPAP 207
TQ + L P+GV GLI P + W+I PA+A G TV+A S
Sbjct: 128 CTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTA 187
Query: 208 LLLAQLAGELGPFPGILNVLSGPASLV-PILASQPGIRKVAFCGAPEEGRALRRSLAGEC 266
+L +L + G PG++N++ G V L S P + ++F G+ + + A C
Sbjct: 188 WMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHC 247
Query: 267 AELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEAMRRLQER 326
+L L LG ++ ++ + A++D + V ++++++ +R ++ ++ + A
Sbjct: 248 KKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQ----VRSYVKRALAEGA------- 296
Query: 327 MGRLRSGRGLDGAVDMGARGAAACDLVQRFVREAQSQGAQVFQAGDVPSERPFYPPTLVS 386
++ G G+D + + AR QAG F PT+++
Sbjct: 297 --QIWCGEGVD-KLSLPARN----------------------QAG------YFMLPTVIT 325
Query: 387 NLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYGLQ 446
++ S C E+ PV PF + +E + AN G +A+VWS +G+ + LQ
Sbjct: 326 DIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQ 385
Query: 447 VGTVWINAHGLRDPSVPTGGCKESGCSWHGGPD 479
G VW N +R+ ++P GG K SG G D
Sbjct: 386 SGLVWTNCWLIRELNLPFGGMKSSGIGREGAKD 418
Score = 83.6 bits (205), Expect = 7e-16
Identities = 68/238 (28%), Positives = 112/238 (47%), Gaps = 7/238 (2%)
Query: 531 FVGGRFQAPGARSSRPIRDSSGNLHGYVAEGGAKDIRGAVEAAHQAFPGWAGQSPGARAA 590
F+ G+F P + S+G ++ V G +I AV+AA +AFP W+ +SP R+
Sbjct: 13 FIDGKF-LPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSR 71
Query: 591 LLWALAAALERRKSTLA-SRLERQGAELKAAEA-EVELSARRLRAW-GARVQAQGHTLQV 647
+L +A LE+ A + + QG L A ++ S + R + + + Q+
Sbjct: 72 VLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQM 131
Query: 648 AGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVC 707
L +R P+GV ++ P PL +APA+A GNTV+ PS + A +C
Sbjct: 132 DHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLC 191
Query: 708 Q--DMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLK 763
+ D A V P G+ N+V G + L H +V + + GS ++ + SA + K
Sbjct: 192 KLLDKAGV-PPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCK 248
>gi|25777721 aldehyde dehydrogenase 5A1 isoform 1 precursor [Homo
sapiens]
Length = 548
Score = 137 bits (345), Expect = 4e-32
Identities = 134/521 (25%), Positives = 220/521 (42%), Gaps = 45/521 (8%)
Query: 5 RAGPRAREIFTSLEYGPVPESHAC---ALAWLDTQDRCLGHYVNGKWLKPEHRNSVPCQD 61
R PRA + + P P C LA L +V G+WL + P QD
Sbjct: 23 RLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALLRTDSFVGGRWLPAAA--TFPVQD 80
Query: 62 PITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWT 121
P +G L + AAV AA AF W R+ L + ++ +++ L
Sbjct: 81 PASGAALGMVADCGVREARAAVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLAR 140
Query: 122 LESLVTGRAVREVRDGDVQLAQQLLHYHAIQA-----------STQEEALAGWEPMGVIG 170
+ + +G+ ++E G++ + L + + +A + AL +P+GV
Sbjct: 141 IITAESGKPLKEAH-GEILYSAFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAA 199
Query: 171 LILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP---LLLAQ-------------LA 214
+I P F + ++ ALA GCTVV V PA P L LA+ LA
Sbjct: 200 VITPWNFPSAMITRKVGAALAAGCTVV--VKPAEDTPFSALALAEVNQGFLLDLDPLLLA 257
Query: 215 GELGPFPGILNVL----SGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAELG 270
+ G G+ NV+ + + + P + K++F G+ G+ L A +
Sbjct: 258 SQAGIPSGVYNVIPCSRKNAKEVGEAICTDPLVSKISFTGSTTTGKILLHHAANSVKRVS 317
Query: 271 LALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGL---RLLIQESVWDEAMRRLQERM 327
+ LG + ++ D+A+VD AV G + + + + G + + L+Q + D ++ E M
Sbjct: 318 MELGGLAPFIVFDSANVDQAVAGAMASKFRNTGQTCVCSNQFLVQRGIHDAFVKAFAEAM 377
Query: 328 GR-LRSGRGLDGAVDMGAR-GAAACDLVQRFVREAQSQGAQVFQAGDVPS-ERPFYPPTL 384
+ LR G G + G A + V++ V +A S+GA V G + F+ PTL
Sbjct: 378 KKNLRVGNGFEEGTTQGPLINEKAVEKVEKQVNDAVSKGATVVTGGKRHQLGKNFFEPTL 437
Query: 385 VSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALELGYG 444
+ N+ C E P+ F T +EA+ +AN G + +S+ Q +
Sbjct: 438 LCNVTQDMLCTHEETFGPLAPVIKFDTEEEAIAIANAADVGLAGYFYSQDPAQIWRVAEQ 497
Query: 445 LQVGTVWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYL 485
L+VG V +N + P GG K+SG G G+ EYL
Sbjct: 498 LEVGMVGVNEGLISSVECPFGGVKQSGLGREGSKYGIDEYL 538
Score = 73.6 bits (179), Expect = 7e-13
Identities = 73/262 (27%), Positives = 112/262 (42%), Gaps = 27/262 (10%)
Query: 450 VWINAHGLRDPSVPTGGCKESGCSWHGGPDGLYEYLRPSGTPARLSCLSKNLNYDTFGLA 509
+W+ + G R G GC GL P+ PA+L C + L + L
Sbjct: 5 IWLRSCGARRL-----GSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGRLAGLSAALL 59
Query: 510 VPSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRD-SSGNLHGYVAEGGAKDIRG 568
+ FVGGR+ A ++ P++D +SG G VA+ G ++ R
Sbjct: 60 RTDS-----------------FVGGRWLP--AAATFPVQDPASGAALGMVADCGVREARA 100
Query: 569 AVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQ-GAELKAAEAEVELS 627
AV AA++AF W S R++LL + + K LA + + G LK A E+ S
Sbjct: 101 AVRAAYEAFCRWREVSAKERSSLLRKWYNLMIQNKDDLARIITAESGKPLKEAHGEILYS 160
Query: 628 ARRLRAWGARVQ-AQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALA 686
A L + + G + L L++P+GV AV+ P +P + ALA
Sbjct: 161 AFFLEWFSEEARRVYGDIIHTPAKDRRALVLKQPIGVAAVITPWNFPSAMITRKVGAALA 220
Query: 687 YGNTVVMVPSAACPLLALEVCQ 708
G TVV+ P+ P AL + +
Sbjct: 221 AGCTVVVKPAEDTPFSALALAE 242
>gi|11095441 aldehyde dehydrogenase 6A1 precursor [Homo sapiens]
Length = 535
Score = 105 bits (261), Expect = 2e-22
Identities = 97/435 (22%), Positives = 189/435 (43%), Gaps = 29/435 (6%)
Query: 43 YVNGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRA 102
++ GK+++ + + +P T E + QA ++ AA+ + + AF W+ + R
Sbjct: 43 FIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQ 102
Query: 103 QHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHY----------HAIQ 152
Q L R ++I+++ + + L +L G+ + + +GDV Q++ + +
Sbjct: 103 QVLLRYQQLIKENLKEIAKLITLEQGKTLADA-EGDVFRGLQVVEHACSVTSLMMGETMP 161
Query: 153 ASTQEEALAGWE-PMGVIGLILPPTFSFLEMMWRICPALAVGCTVVALVPPASPAP---L 208
+ T++ L + P+GV I P F + +W A+ G T L+ P+ P +
Sbjct: 162 SITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTF--LMKPSERVPGATM 219
Query: 209 LLAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGECAE 268
LLA+L + G G LN++ G V + P I+ ++F G+ + G + +
Sbjct: 220 LLAKLLQDSGAPDGTLNIIHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKR 279
Query: 269 LGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPGGLRLLIQESVWDEA--MRRLQER 326
+ +G ++ ++ A+ ++ + +V AA+ G + L V + + L E
Sbjct: 280 VQANMGAKNHGVVMPDANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEH 339
Query: 327 MGRLRSGRGLDGAVDMGA-----RGAAACDLVQRFVREAQS---QGAQVFQAGDVPSERP 378
LR G D+G C+L+ +E S G ++ G
Sbjct: 340 AKNLRVNAGDQPGADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGN-- 397
Query: 379 FYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQA 438
F PT++SN+ P C + E+ PV+V T EA+ + N P G ++++ A
Sbjct: 398 FVGPTIISNVKPNMTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATA 457
Query: 439 LELGYGLQVGTVWIN 453
+ + + VG V +N
Sbjct: 458 RKYAHLVDVGQVGVN 472
Score = 68.2 bits (165), Expect = 3e-11
Identities = 62/254 (24%), Positives = 110/254 (43%), Gaps = 9/254 (3%)
Query: 523 SPAPPYGLFVGGRFQAPGARSSRPIRDSSGN-LHGYVAEGGAKDIRGAVEAAHQAFPGWA 581
S P LF+GG+F + I + + N + G V + ++ A+ + +AFP WA
Sbjct: 35 SSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWA 94
Query: 582 GQSPGARAALLWALAAALERRKSTLASRLE-RQGAELKAAEAEVELSARRLR-AWGARVQ 639
S +R +L ++ +A + QG L AE +V + + A
Sbjct: 95 DTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSL 154
Query: 640 AQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAAC 699
G T+ + R PLGV A + P +P + + + A+ GNT +M PS
Sbjct: 155 MMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERV 214
Query: 700 P---LLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEW 756
P +L ++ QD P G N++ G + + H D++A+ + GS + +++
Sbjct: 215 PGATMLLAKLLQDSGA--PDGTLNIIHGQHE-AVNFICDHPDIKAISFVGSNKAGEYIFE 271
Query: 757 ASAGNLKPVWASRG 770
+ + K V A+ G
Sbjct: 272 RGSRHGKRVQANMG 285
>gi|188035924 aldehyde dehydrogenase 7 family, member A1 [Homo
sapiens]
Length = 539
Score = 100 bits (248), Expect = 7e-21
Identities = 118/479 (24%), Positives = 200/479 (41%), Gaps = 49/479 (10%)
Query: 45 NGKWLKPEHRNSVPCQDPITGENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQH 104
NG W + C P E +A QA D V+ AR A+K W+ P R +
Sbjct: 56 NGSWGGRGEVITTYC--PANNEPIARVRQASVADYEETVKKAREAWKIWADIPAPKRGEI 113
Query: 105 LTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLLHYHA----------IQAS 154
+ ++ + +++ ++L +L SL G+ + E G+VQ + Y + +
Sbjct: 114 VRQIGDALREKIQVLGSLVSLEMGKILVE-GVGEVQEYVDICDYAVGLSRMIGGPILPSE 172
Query: 155 TQEEALAG-WEPMGVIGLILPPTFSFLEMMWRICPALAVGCTVVAL---VPPASPAPLLL 210
AL W P+G++G+I F W A+A+ C V L P S + +
Sbjct: 173 RSGHALIEQWNPVGLVGIITAFNFPVAVYGWN--NAIAMICGNVCLWKGAPTTSLISVAV 230
Query: 211 AQLAGEL---GPFPG-ILNVLSGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGEC 266
++ ++ PG I ++ G A + +A + ++F G+ + G+ + +
Sbjct: 231 TKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVNLLSFTGSTQVGKQVGLMVQERF 290
Query: 267 AELGLALGTESLLLLTDTADVDSAVEGVVDAAWSDRGPG---GLRLLIQESVWDEAMRRL 323
L LG + ++ + AD+ V + AA G RL I ES+ DE + RL
Sbjct: 291 GRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQRCTTARRLFIHESIHDEVVNRL 350
Query: 324 QERMGRLRSGRGLDGAVDMGA-RGAAACDLVQRFVREAQSQGAQVFQAGDVPSERP--FY 380
++ ++R G D V G A + V EA+ +G V G V +RP +
Sbjct: 351 KKAYAQIRVGNPWDPNVLYGPLHTKQAVSMFLGAVEEAKKEGGTVVYGGKV-MDRPGNYV 409
Query: 381 PPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEALLVANGTPRGGSASVWSERLGQALE 440
PT+V+ L + A E P++ F+ +E N +G S+S++++ LG+
Sbjct: 410 EPTIVTGLGHDASIAHTETFAPILYVFKFKNEEEVFAWNNEVKQGLSSSIFTKDLGRIFR 469
Query: 441 -LG-YGLQVGTVWINAHGLRDPSVPT---------GGCKESGCSWHGGPDGLYEYLRPS 488
LG G G V +N +PT GG K +G G D +Y+R S
Sbjct: 470 WLGPKGSDCGIVNVN--------IPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRS 520
>gi|25777736 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 64.3 bits (155), Expect = 4e-10
Identities = 115/472 (24%), Positives = 188/472 (39%), Gaps = 64/472 (13%)
Query: 65 GENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLES 124
G +A A + A+EAA A K W P RAQ + A+++ +R ++
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 147
Query: 125 LVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM---------------GVI 169
+V G+ + V ++ A +L+ + A E L G +P+ G +
Sbjct: 148 MV-GQG-KTVIQAEIDAAAELIDFFRFNAKYAVE-LEGQQPISVPPSTNSTVYRGLEGFV 204
Query: 170 GLILPPTFSFLEMMWRICPALAVGCTVVALVP--PASPAPLLLAQLAGELGPFPGILNVL 227
I P F+F + + A A+ VV P A A + ++ E G P I+ +
Sbjct: 205 AAISP--FNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFV 262
Query: 228 SGPASLV-PILASQPGIRKVAFCGAPEEGRALRRS-------------LAGECAELGLAL 273
L + S + + F G+ + L + LAGEC
Sbjct: 263 PADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGEC------- 315
Query: 274 GTESLLLLTDTADVDSAVEGVVDAAWSDRG---PGGLRLLIQESVWDEAMRRLQERMGRL 330
G ++ + +ADV+S V G + +A+ G RL + S+W + RL E R+
Sbjct: 316 GGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRI 375
Query: 331 RSGRGLDGAVDMGARGAAACDL-----VQRFVREAQSQGAQVFQAGDV--PSERPFYPPT 383
+ G D A D G +A D +++++ A+S + AG S F P
Sbjct: 376 KVG---DPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPC 432
Query: 384 LVSNLPPASPCAQVEVPWPV--VVASPFRTAKEAL-LVANGTPRGGSASVWSERLGQALE 440
+V + P P + E+ PV V P KE L LV + T G + +V+S+ E
Sbjct: 433 IVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQE 492
Query: 441 LGYGLQ--VGTVWIN--AHGLRDPSVPTGGCKESGCS-WHGGPDGLYEYLRP 487
L+ G +IN + G P GG + SG + GGP + + P
Sbjct: 493 ATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSP 544
>gi|238859541 aldehyde dehydrogenase 4A1 isoform b [Homo sapiens]
Length = 503
Score = 64.3 bits (155), Expect = 4e-10
Identities = 115/472 (24%), Positives = 188/472 (39%), Gaps = 64/472 (13%)
Query: 65 GENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLES 124
G +A A + A+EAA A K W P RAQ + A+++ +R ++
Sbjct: 28 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 87
Query: 125 LVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM---------------GVI 169
+V G+ + V ++ A +L+ + A E L G +P+ G +
Sbjct: 88 MV-GQG-KTVIQAEIDAAAELIDFFRFNAKYAVE-LEGQQPISVPPSTNSTVYRGLEGFV 144
Query: 170 GLILPPTFSFLEMMWRICPALAVGCTVVALVP--PASPAPLLLAQLAGELGPFPGILNVL 227
I P F+F + + A A+ VV P A A + ++ E G P I+ +
Sbjct: 145 AAISP--FNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFV 202
Query: 228 SGPASLV-PILASQPGIRKVAFCGAPEEGRALRRS-------------LAGECAELGLAL 273
L + S + + F G+ + L + LAGEC
Sbjct: 203 PADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGEC------- 255
Query: 274 GTESLLLLTDTADVDSAVEGVVDAAWSDRG---PGGLRLLIQESVWDEAMRRLQERMGRL 330
G ++ + +ADV+S V G + +A+ G RL + S+W + RL E R+
Sbjct: 256 GGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRI 315
Query: 331 RSGRGLDGAVDMGARGAAACDL-----VQRFVREAQSQGAQVFQAGDV--PSERPFYPPT 383
+ G D A D G +A D +++++ A+S + AG S F P
Sbjct: 316 KVG---DPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPC 372
Query: 384 LVSNLPPASPCAQVEVPWPV--VVASPFRTAKEAL-LVANGTPRGGSASVWSERLGQALE 440
+V + P P + E+ PV V P KE L LV + T G + +V+S+ E
Sbjct: 373 IVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQE 432
Query: 441 LGYGLQ--VGTVWIN--AHGLRDPSVPTGGCKESGCS-WHGGPDGLYEYLRP 487
L+ G +IN + G P GG + SG + GGP + + P
Sbjct: 433 ATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSP 484
>gi|25777734 aldehyde dehydrogenase 4A1 isoform a precursor [Homo
sapiens]
Length = 563
Score = 64.3 bits (155), Expect = 4e-10
Identities = 115/472 (24%), Positives = 188/472 (39%), Gaps = 64/472 (13%)
Query: 65 GENLASCLQAQAEDVAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLES 124
G +A A + A+EAA A K W P RAQ + A+++ +R ++
Sbjct: 88 GHKVAKFCYADKSLLNKAIEAALAARKEWDLKPIADRAQIFLKAADMLSGPRRAEILAKT 147
Query: 125 LVTGRAVREVRDGDVQLAQQLLHYHAIQASTQEEALAGWEPM---------------GVI 169
+V G+ + V ++ A +L+ + A E L G +P+ G +
Sbjct: 148 MV-GQG-KTVIQAEIDAAAELIDFFRFNAKYAVE-LEGQQPISVPPSTNSTVYRGLEGFV 204
Query: 170 GLILPPTFSFLEMMWRICPALAVGCTVVALVP--PASPAPLLLAQLAGELGPFPGILNVL 227
I P F+F + + A A+ VV P A A + ++ E G P I+ +
Sbjct: 205 AAISP--FNFTAIGGNLAGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFV 262
Query: 228 SGPASLV-PILASQPGIRKVAFCGAPEEGRALRRS-------------LAGECAELGLAL 273
L + S + + F G+ + L + LAGEC
Sbjct: 263 PADGPLFGDTVTSSEHLCGINFTGSVPTFKHLWKQVAQNLDRFHTFPRLAGEC------- 315
Query: 274 GTESLLLLTDTADVDSAVEGVVDAAWSDRG---PGGLRLLIQESVWDEAMRRLQERMGRL 330
G ++ + +ADV+S V G + +A+ G RL + S+W + RL E R+
Sbjct: 316 GGKNFHFVHRSADVESVVSGTLRSAFEYGGQKCSACSRLYVPHSLWPQIKGRLLEEHSRI 375
Query: 331 RSGRGLDGAVDMGARGAAACDL-----VQRFVREAQSQGAQVFQAGDV--PSERPFYPPT 383
+ G D A D G +A D +++++ A+S + AG S F P
Sbjct: 376 KVG---DPAEDFGTFFSAVIDAKSFARIKKWLEHARSSPSLTILAGGKCDDSVGYFVEPC 432
Query: 384 LVSNLPPASPCAQVEVPWPV--VVASPFRTAKEAL-LVANGTPRGGSASVWSERLGQALE 440
+V + P P + E+ PV V P KE L LV + T G + +V+S+ E
Sbjct: 433 IVESKDPQEPIMKEEIFGPVLSVYVYPDDKYKETLQLVDSTTSYGLTGAVFSQDKDVVQE 492
Query: 441 LGYGLQ--VGTVWIN--AHGLRDPSVPTGGCKESGCS-WHGGPDGLYEYLRP 487
L+ G +IN + G P GG + SG + GGP + + P
Sbjct: 493 ATKVLRNAAGNFYINDKSTGSIVGQQPFGGARASGTNDKPGGPHYILRWTSP 544
>gi|238814371 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 50.1 bits (118), Expect = 8e-06
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 14/192 (7%)
Query: 588 RAALLWALAAALERRKSTL---------ASRLERQGAELKAAEAEVELSARRLRAWGARV 638
RAA L L L+ K L S E + +E+ ++ EV L+ R LRAW +
Sbjct: 26 RAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQGEVTLALRNLRAW---M 82
Query: 639 QAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAA 698
+ + +A +EP G++ ++ P +PL + L ALA GN VV+ PS
Sbjct: 83 KDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEI 142
Query: 699 CPLLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWAS 758
+ + + + VV G + L D +++ GS + + V A+
Sbjct: 143 SKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAA 200
Query: 759 AGNLKPVWASRG 770
A +L PV G
Sbjct: 201 AKHLTPVTLELG 212
Score = 36.6 bits (83), Expect = 0.095
Identities = 53/231 (22%), Positives = 89/231 (38%), Gaps = 26/231 (11%)
Query: 87 RMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW----------TLESLVTGRAVREVRD 136
R AF P RA L L +Q++++LL ES V+ A+ +
Sbjct: 12 REAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQ--- 68
Query: 137 GDVQLAQQLLHYHAIQ-------ASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPA 189
G+V LA + L A+ + A EP G++ +I P + + + A
Sbjct: 69 GEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGA 128
Query: 190 LAVG-CTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAF 248
LA G C V+ + +LA++ + VL GP +L + + F
Sbjct: 129 LAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR--FDYIFF 186
Query: 249 CGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAW 299
G+P G+ + + A + L LG ++ + D D + V AW
Sbjct: 187 TGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRV---AW 234
>gi|4502043 aldehyde dehydrogenase 3B1 isoform a [Homo sapiens]
Length = 468
Score = 50.1 bits (118), Expect = 8e-06
Identities = 50/192 (26%), Positives = 81/192 (42%), Gaps = 14/192 (7%)
Query: 588 RAALLWALAAALERRKSTL---------ASRLERQGAELKAAEAEVELSARRLRAWGARV 638
RAA L L L+ K L S E + +E+ ++ EV L+ R LRAW +
Sbjct: 26 RAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQGEVTLALRNLRAW---M 82
Query: 639 QAQGHTLQVAGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAA 698
+ + +A +EP G++ ++ P +PL + L ALA GN VV+ PS
Sbjct: 83 KDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEI 142
Query: 699 CPLLALEVCQDMATVFPAGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWAS 758
+ + + + VV G + L D +++ GS + + V A+
Sbjct: 143 SKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAA 200
Query: 759 AGNLKPVWASRG 770
A +L PV G
Sbjct: 201 AKHLTPVTLELG 212
Score = 36.6 bits (83), Expect = 0.095
Identities = 53/231 (22%), Positives = 89/231 (38%), Gaps = 26/231 (11%)
Query: 87 RMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLW----------TLESLVTGRAVREVRD 136
R AF P RA L L +Q++++LL ES V+ A+ +
Sbjct: 12 REAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDALAQDLHKSAFESEVSEVAISQ--- 68
Query: 137 GDVQLAQQLLHYHAIQ-------ASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPA 189
G+V LA + L A+ + A EP G++ +I P + + + A
Sbjct: 69 GEVTLALRNLRAWMKDERVPKNLATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGA 128
Query: 190 LAVG-CTVVALVPPASPAPLLLAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAF 248
LA G C V+ + +LA++ + VL GP +L + + F
Sbjct: 129 LAAGNCVVLKPSEISKNVEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR--FDYIFF 186
Query: 249 CGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAAW 299
G+P G+ + + A + L LG ++ + D D + V AW
Sbjct: 187 TGSPRVGKIVMTAAAKHLTPVTLELGGKNPCYVDDNCDPQTVANRV---AW 234
>gi|22907049 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 46.2 bits (108), Expect = 1e-04
Identities = 87/429 (20%), Positives = 166/429 (38%), Gaps = 48/429 (11%)
Query: 79 VAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLL------------WTLESLV 126
++ AV+ AR AF P R Q L L +IQ+ ++ L W
Sbjct: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63
Query: 127 TGRAVREVRDGDVQLAQQLLHYHAIQA------STQEEALAGWEPMGVIGLILPPTFSFL 180
+ E+ + Q+L + A + + Q+E EP+GV+ +I + F
Sbjct: 64 VVYVLEEIE----YMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119
Query: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPF--PGILNVLSGPASLVPILA 238
+ + A+A G +VV + P+ + + + LA + + + V++G L
Sbjct: 120 LTIQPMVGAIAAGNSVV--LKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
Query: 239 SQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAA 298
+ + + G+ G+ + + A + L LG +S + D+D A +
Sbjct: 178 KER-FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 299 WSDRGPGGLR---LLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQR 355
+ + G + +L S+ ++ + +L++ L+ G D + QR
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKS---LKEFYGEDAKKSRDYGRIISARHFQR 293
Query: 356 FVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEA 415
+ + Q GD + + PT+++++ P SP Q E+ PV+ R+ +EA
Sbjct: 294 VMGLIEGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
Query: 416 LLVANGTPR-------GGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCK 468
+ N + + V + + + G V I H S+P GG
Sbjct: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH-----SLPFGGVG 406
Query: 469 ESGC-SWHG 476
SG S+HG
Sbjct: 407 NSGMGSYHG 415
Score = 37.7 bits (86), Expect = 0.043
Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 10/116 (8%)
Query: 659 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFP--- 715
EPLGV+ V+ +P + + A+A GN+VV+ PS L+ + +AT+ P
Sbjct: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSE----LSENMASLLATIIPQYL 158
Query: 716 -AGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 770
L V+ G T L D + Y GS + + A+A +L PV G
Sbjct: 159 DKDLYPVINGGVPETTELLKERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELG 212
>gi|206597441 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 46.2 bits (108), Expect = 1e-04
Identities = 87/429 (20%), Positives = 166/429 (38%), Gaps = 48/429 (11%)
Query: 79 VAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLL------------WTLESLV 126
++ AV+ AR AF P R Q L L +IQ+ ++ L W
Sbjct: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63
Query: 127 TGRAVREVRDGDVQLAQQLLHYHAIQA------STQEEALAGWEPMGVIGLILPPTFSFL 180
+ E+ + Q+L + A + + Q+E EP+GV+ +I + F
Sbjct: 64 VVYVLEEIE----YMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119
Query: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPF--PGILNVLSGPASLVPILA 238
+ + A+A G +VV + P+ + + + LA + + + V++G L
Sbjct: 120 LTIQPMVGAIAAGNSVV--LKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
Query: 239 SQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAA 298
+ + + G+ G+ + + A + L LG +S + D+D A +
Sbjct: 178 KER-FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 299 WSDRGPGGLR---LLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQR 355
+ + G + +L S+ ++ + +L++ L+ G D + QR
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKS---LKEFYGEDAKKSRDYGRIISARHFQR 293
Query: 356 FVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEA 415
+ + Q GD + + PT+++++ P SP Q E+ PV+ R+ +EA
Sbjct: 294 VMGLIEGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
Query: 416 LLVANGTPR-------GGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCK 468
+ N + + V + + + G V I H S+P GG
Sbjct: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH-----SLPFGGVG 406
Query: 469 ESGC-SWHG 476
SG S+HG
Sbjct: 407 NSGMGSYHG 415
Score = 37.7 bits (86), Expect = 0.043
Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 10/116 (8%)
Query: 659 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFP--- 715
EPLGV+ V+ +P + + A+A GN+VV+ PS L+ + +AT+ P
Sbjct: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSE----LSENMASLLATIIPQYL 158
Query: 716 -AGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 770
L V+ G T L D + Y GS + + A+A +L PV G
Sbjct: 159 DKDLYPVINGGVPETTELLKERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELG 212
>gi|206597439 aldehyde dehydrogenase 3A1 [Homo sapiens]
Length = 453
Score = 46.2 bits (108), Expect = 1e-04
Identities = 87/429 (20%), Positives = 166/429 (38%), Gaps = 48/429 (11%)
Query: 79 VAAAVEAARMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLL------------WTLESLV 126
++ AV+ AR AF P R Q L L +IQ+ ++ L W
Sbjct: 4 ISEAVKRARAAFSSGRTRPLQFRIQQLEALQRLIQEQEQELVGALAADLHKNEWNAYYEE 63
Query: 127 TGRAVREVRDGDVQLAQQLLHYHAIQA------STQEEALAGWEPMGVIGLILPPTFSFL 180
+ E+ + Q+L + A + + Q+E EP+GV+ +I + F
Sbjct: 64 VVYVLEEIE----YMIQKLPEWAADEPVEKTPQTQQDELYIHSEPLGVVLVIGTWNYPFN 119
Query: 181 EMMWRICPALAVGCTVVALVPPASPAPLLLAQLAGELGPF--PGILNVLSGPASLVPILA 238
+ + A+A G +VV + P+ + + + LA + + + V++G L
Sbjct: 120 LTIQPMVGAIAAGNSVV--LKPSELSENMASLLATIIPQYLDKDLYPVINGGVPETTELL 177
Query: 239 SQPGIRKVAFCGAPEEGRALRRSLAGECAELGLALGTESLLLLTDTADVDSAVEGVVDAA 298
+ + + G+ G+ + + A + L LG +S + D+D A +
Sbjct: 178 KER-FDHILYTGSTGVGKIIMTAAAKHLTPVTLELGGKSPCYVDKNCDLDVACRRIAWGK 236
Query: 299 WSDRGPGGLR---LLIQESVWDEAMRRLQERMGRLRSGRGLDGAVDMGARGAAACDLVQR 355
+ + G + +L S+ ++ + +L++ L+ G D + QR
Sbjct: 237 FMNSGQTCVAPDYILCDPSIQNQIVEKLKKS---LKEFYGEDAKKSRDYGRIISARHFQR 293
Query: 356 FVREAQSQGAQVFQAGDVPSERPFYPPTLVSNLPPASPCAQVEVPWPVVVASPFRTAKEA 415
+ + Q GD + + PT+++++ P SP Q E+ PV+ R+ +EA
Sbjct: 294 VMGLIEGQKVAYGGTGDAATR--YIAPTILTDVDPQSPVMQEEIFGPVLPIVCVRSLEEA 351
Query: 416 LLVANGTPR-------GGSASVWSERLGQALELGYGLQVGTVWINAHGLRDPSVPTGGCK 468
+ N + + V + + + G V I H S+P GG
Sbjct: 352 IQFINQREKPLALYMFSSNDKVIKKMIAETSSGGVAANDVIVHITLH-----SLPFGGVG 406
Query: 469 ESGC-SWHG 476
SG S+HG
Sbjct: 407 NSGMGSYHG 415
Score = 37.7 bits (86), Expect = 0.043
Identities = 34/116 (29%), Positives = 52/116 (44%), Gaps = 10/116 (8%)
Query: 659 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFP--- 715
EPLGV+ V+ +P + + A+A GN+VV+ PS L+ + +AT+ P
Sbjct: 103 EPLGVVLVIGTWNYPFNLTIQPMVGAIAAGNSVVLKPSE----LSENMASLLATIIPQYL 158
Query: 716 -AGLANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 770
L V+ G T L D + Y GS + + A+A +L PV G
Sbjct: 159 DKDLYPVINGGVPETTELLKERFD--HILYTGSTGVGKIIMTAAAKHLTPVTLELG 212
>gi|57222568 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 6 [Homo sapiens]
Length = 1093
Score = 40.8 bits (94), Expect = 0.005
Identities = 56/212 (26%), Positives = 83/212 (39%), Gaps = 25/212 (11%)
Query: 511 PSTLPAGPEIGPSPAPPYGLFVGGRFQAPGARSSRPIRDSSGNLHGYVAEGG--AKDIRG 568
P+TLP P+P PP G +APGA + + G L G GG + G
Sbjct: 844 PATLPLALPGAPAPLPPQP--QNGLGRAPGAAGLGAMPMAEGLLGGLAGSGGLPLNGLLG 901
Query: 569 AVEAAHQAFPGWAGQSPGARAALLWALAAALERRKSTLASRLERQGAELKAAEAEVELSA 628
+ A P Q+ GA L +L ++ L + E+Q +L+ A +L+
Sbjct: 902 GLNGAAAPNPASLSQAGGAPTLQLPGCLNSLTEQQRHLLQQQEQQLQQLQQLLASPQLTP 961
Query: 629 RRLRAWGARVQ--AQGHTLQ---------------VAGLRGPVLRLREPLGVLAVVCPDE 671
+Q Q LQ +AG P+L P G+L
Sbjct: 962 EHQTVVYQMIQQIQQKRELQRLQMAGGSQLPMASLLAGSSTPLLSAGTP-GLLPTASAP- 1019
Query: 672 WPLLAFVSLLAPALAYGNTVVMVPSAACPLLA 703
PLL +L+AP+L NT +M +AA +A
Sbjct: 1020 -PLLPAGALVAPSLG-NNTSLMAAAAAAAAVA 1049
>gi|4557303 aldehyde dehydrogenase 3A2 isoform 2 [Homo sapiens]
Length = 485
Score = 38.1 bits (87), Expect = 0.033
Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 2/112 (1%)
Query: 659 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGL 718
+PLGV+ ++ +P + + L A+A GN V++ PS A + + + L
Sbjct: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDL 159
Query: 719 ANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 770
V+ G + T L Q ++Y G+ + V A+A +L PV G
Sbjct: 160 YIVINGGVEETTE--LLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELG 209
>gi|73466520 aldehyde dehydrogenase 3A2 isoform 1 [Homo sapiens]
Length = 508
Score = 38.1 bits (87), Expect = 0.033
Identities = 29/112 (25%), Positives = 50/112 (44%), Gaps = 2/112 (1%)
Query: 659 EPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAGL 718
+PLGV+ ++ +P + + L A+A GN V++ PS A + + + L
Sbjct: 100 QPLGVVLIIGAWNYPFVLTIQPLIGAIAAGNAVIIKPSELSENTAKILAKLLPQYLDQDL 159
Query: 719 ANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 770
V+ G + T L Q ++Y G+ + V A+A +L PV G
Sbjct: 160 YIVINGGVEETTE--LLKQRFDHIFYTGNTAVGKIVMEAAAKHLTPVTLELG 209
>gi|71773324 aldehyde dehydrogenase 3B1 isoform b [Homo sapiens]
Length = 431
Score = 37.0 bits (84), Expect = 0.073
Identities = 30/113 (26%), Positives = 50/113 (44%), Gaps = 2/113 (1%)
Query: 658 REPLGVLAVVCPDEWPLLAFVSLLAPALAYGNTVVMVPSAACPLLALEVCQDMATVFPAG 717
+EP G++ ++ P +PL + L ALA GN VV+ PS + + + +
Sbjct: 65 KEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKNVEKILAEVLPQYVDQS 124
Query: 718 LANVVTGDRDHLTRCLALHQDVQAMWYFGSAQGSQFVEWASAGNLKPVWASRG 770
VV G + L D +++ GS + + V A+A +L PV G
Sbjct: 125 CFAVVLGGPQETGQLLEHRFDY--IFFTGSPRVGKIVMTAAAKHLTPVTLELG 175
Score = 35.0 bits (79), Expect = 0.28
Identities = 48/214 (22%), Positives = 80/214 (37%), Gaps = 29/214 (13%)
Query: 87 RMAFKGWSAHPGVVRAQHLTRLAEVIQKHQRLLWTLESLVTGRAVREVRDGDVQLAQQLL 146
R AF P RA L L +Q++++LL LAQ L
Sbjct: 12 REAFHAGRTRPAEFRAAQLQGLGRFLQENKQLLHDA------------------LAQDLH 53
Query: 147 HYHAIQASTQEEALAGWEPMGVIGLILPPTFSFLEMMWRICPALAVG-CTVVALVPPASP 205
+A+ + A EP G++ +I P + + + ALA G C V+ +
Sbjct: 54 -----KATQLDSAFIRKEPFGLVLIIAPWNYPLNLTLVPLVGALAAGNCVVLKPSEISKN 108
Query: 206 APLLLAQLAGELGPFPGILNVLSGPASLVPILASQPGIRKVAFCGAPEEGRALRRSLAGE 265
+LA++ + VL GP +L + + F G+P G+ + + A
Sbjct: 109 VEKILAEVLPQYVDQSCFAVVLGGPQETGQLLEHR--FDYIFFTGSPRVGKIVMTAAAKH 166
Query: 266 CAELGLALGTESLLLLTDTADVDSAVEGVVDAAW 299
+ L LG ++ + D D + V AW
Sbjct: 167 LTPVTLELGGKNPCYVDDNCDPQTVANRV---AW 197
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,664,475
Number of Sequences: 37866
Number of extensions: 1789793
Number of successful extensions: 6080
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 49
Number of HSP's that attempted gapping in prelim test: 5897
Number of HSP's gapped (non-prelim): 152
length of query: 802
length of database: 18,247,518
effective HSP length: 110
effective length of query: 692
effective length of database: 14,082,258
effective search space: 9744922536
effective search space used: 9744922536
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.