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Search of human proteins with 223029472
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|223029472 NEL-like protein 2 isoform b precursor [Homo
sapiens]
(816 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|223029476 NEL-like protein 2 isoform d [Homo sapiens] 1799 0.0
gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens] 1799 0.0
gi|223029470 NEL-like protein 2 isoform a [Homo sapiens] 1799 0.0
gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens] 1799 0.0
gi|223029474 NEL-like protein 2 isoform c [Homo sapiens] 1765 0.0
gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens] 1047 0.0
gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens] 929 0.0
gi|66346695 fibrillin 2 precursor [Homo sapiens] 166 6e-41
gi|24430141 fibrillin 1 precursor [Homo sapiens] 157 4e-38
gi|56237021 fibrillin 3 precursor [Homo sapiens] 156 6e-38
gi|51873053 fibulin 2 isoform a precursor [Homo sapiens] 155 1e-37
gi|134244285 Notch homolog 3 [Homo sapiens] 154 2e-37
gi|24041035 notch 2 preproprotein [Homo sapiens] 147 5e-35
gi|118572606 hemicentin 1 [Homo sapiens] 147 5e-35
gi|148833508 notch1 preproprotein [Homo sapiens] 146 9e-35
gi|40807489 egf-like module containing, mucin-like, hormone rece... 142 1e-33
gi|51873055 fibulin 2 isoform b precursor [Homo sapiens] 139 1e-32
gi|17978491 CD97 antigen isoform 1 precursor [Homo sapiens] 138 2e-32
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 136 9e-32
gi|34734064 fibulin 1 isoform B precursor [Homo sapiens] 135 2e-31
gi|34734068 fibulin 1 isoform A precursor [Homo sapiens] 135 2e-31
gi|34734066 fibulin 1 isoform D [Homo sapiens] 135 2e-31
gi|34734062 fibulin 1 isoform C precursor [Homo sapiens] 135 2e-31
gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens] 135 2e-31
gi|4557679 jagged 1 precursor [Homo sapiens] 134 3e-31
gi|46249414 latent transforming growth factor beta binding prote... 130 4e-30
gi|46249412 latent transforming growth factor beta binding prote... 130 4e-30
gi|110347437 latent transforming growth factor beta binding prot... 129 8e-30
gi|110347412 latent transforming growth factor beta binding prot... 129 8e-30
gi|110347431 latent transforming growth factor beta binding prot... 129 8e-30
>gi|223029476 NEL-like protein 2 isoform d [Homo sapiens]
Length = 839
Score = 1799 bits (4660), Expect = 0.0
Identities = 816/816 (100%), Positives = 816/816 (100%)
Query: 1 MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60
MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF
Sbjct: 24 MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 83
Query: 61 QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120
QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG
Sbjct: 84 QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 143
Query: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180
HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS
Sbjct: 144 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 203
Query: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240
TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK
Sbjct: 204 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 263
Query: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300
IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT
Sbjct: 264 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 323
Query: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360
IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE
Sbjct: 324 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 383
Query: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420
CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA
Sbjct: 384 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 443
Query: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC
Sbjct: 444 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 503
Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540
TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV
Sbjct: 504 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 563
Query: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC
Sbjct: 564 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 623
Query: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660
EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC
Sbjct: 624 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 683
Query: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ
Sbjct: 684 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 743
Query: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV
Sbjct: 744 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 803
Query: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816
RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
Sbjct: 804 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 839
>gi|223029472 NEL-like protein 2 isoform b precursor [Homo sapiens]
Length = 816
Score = 1799 bits (4660), Expect = 0.0
Identities = 816/816 (100%), Positives = 816/816 (100%)
Query: 1 MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60
MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF
Sbjct: 1 MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60
Query: 61 QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120
QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG
Sbjct: 61 QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120
Query: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180
HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS
Sbjct: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180
Query: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240
TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK
Sbjct: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240
Query: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300
IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT
Sbjct: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300
Query: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360
IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE
Sbjct: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360
Query: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420
CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA
Sbjct: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420
Query: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC
Sbjct: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540
TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV
Sbjct: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540
Query: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC
Sbjct: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
Query: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660
EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC
Sbjct: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660
Query: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ
Sbjct: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
Query: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV
Sbjct: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
Query: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816
RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
Sbjct: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816
>gi|223029470 NEL-like protein 2 isoform a [Homo sapiens]
Length = 866
Score = 1799 bits (4660), Expect = 0.0
Identities = 816/816 (100%), Positives = 816/816 (100%)
Query: 1 MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60
MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF
Sbjct: 51 MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 110
Query: 61 QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120
QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG
Sbjct: 111 QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 170
Query: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180
HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS
Sbjct: 171 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 230
Query: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240
TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK
Sbjct: 231 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 290
Query: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300
IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT
Sbjct: 291 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 350
Query: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360
IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE
Sbjct: 351 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 410
Query: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420
CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA
Sbjct: 411 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 470
Query: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC
Sbjct: 471 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 530
Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540
TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV
Sbjct: 531 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 590
Query: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC
Sbjct: 591 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 650
Query: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660
EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC
Sbjct: 651 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 710
Query: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ
Sbjct: 711 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 770
Query: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV
Sbjct: 771 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 830
Query: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816
RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
Sbjct: 831 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 866
>gi|5453766 NEL-like protein 2 isoform b precursor [Homo sapiens]
Length = 816
Score = 1799 bits (4660), Expect = 0.0
Identities = 816/816 (100%), Positives = 816/816 (100%)
Query: 1 MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60
MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF
Sbjct: 1 MESRVLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLF 60
Query: 61 QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120
QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG
Sbjct: 61 QDTPRSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSG 120
Query: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180
HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS
Sbjct: 121 HRNEVRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPS 180
Query: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240
TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK
Sbjct: 181 TDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQK 240
Query: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300
IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT
Sbjct: 241 IMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGT 300
Query: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360
IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE
Sbjct: 301 IQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYE 360
Query: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420
CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA
Sbjct: 361 CKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRA 420
Query: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC
Sbjct: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540
TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV
Sbjct: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANV 540
Query: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC
Sbjct: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
Query: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660
EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC
Sbjct: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC 660
Query: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ
Sbjct: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
Query: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV
Sbjct: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
Query: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816
RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL
Sbjct: 781 RFTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQEL 816
>gi|223029474 NEL-like protein 2 isoform c [Homo sapiens]
Length = 815
Score = 1765 bits (4571), Expect = 0.0
Identities = 798/799 (99%), Positives = 799/799 (100%)
Query: 18 AVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQF 77
+VWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQF
Sbjct: 17 SVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTPRSIKASTATAEQF 76
Query: 78 FQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPH 137
FQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPH
Sbjct: 77 FQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPH 136
Query: 138 TEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNA 197
TEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNA
Sbjct: 137 TEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLPLGTTFWLGQRNNA 196
Query: 198 HGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSR 257
HGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSR
Sbjct: 197 HGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAKTSAKLSR 256
Query: 258 AEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKS 317
AEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKS
Sbjct: 257 AEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKS 316
Query: 318 ALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPAL 377
ALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPAL
Sbjct: 317 ALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPAL 376
Query: 378 DCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAY 437
DCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAY
Sbjct: 377 DCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAY 436
Query: 438 CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENA 497
CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENA
Sbjct: 437 CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENA 496
Query: 498 LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDID 557
LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDID
Sbjct: 497 LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDID 556
Query: 558 ECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDT 617
ECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDT
Sbjct: 557 ECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDT 616
Query: 618 ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC 677
ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC
Sbjct: 617 ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC 676
Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCP 737
DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCP
Sbjct: 677 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCP 736
Query: 738 DVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLC 797
DVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLC
Sbjct: 737 DVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLC 796
Query: 798 QCKNGHICCSVDPQCLQEL 816
QCKNGHICCSVDPQCLQEL
Sbjct: 797 QCKNGHICCSVDPQCLQEL 815
>gi|222352164 nel-like 1 isoform 1 precursor [Homo sapiens]
Length = 810
Score = 1047 bits (2707), Expect = 0.0
Identities = 452/813 (55%), Positives = 586/813 (72%), Gaps = 13/813 (1%)
Query: 5 VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 64
+L+ FC+ V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD
Sbjct: 6 ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64
Query: 65 RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 124
R I A+ +E+ Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E
Sbjct: 65 REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124
Query: 125 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 184
+R HY +P TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183
Query: 185 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 244
G WLGQRN HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+L
Sbjct: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243
Query: 245 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 302
Q++LAK +AKL+ AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++
Sbjct: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303
Query: 303 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 362
C + CP +C S ++ G+CCK C+ C + G+ EG+R S EC+
Sbjct: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357
Query: 363 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 421
+ K+ E CP L+C E I + CC+VC+G++FC+E C ENS C+N N +A
Sbjct: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415
Query: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 481
C C+ G+ +++ D+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCT
Sbjct: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475
Query: 482 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 541
EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535
Query: 542 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 601
CP GFTG CE DIDECS+G ++C + + C+NLPGWYHCECR G+HD+G +S SGESC
Sbjct: 536 VCPSGFTGSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCI 595
Query: 602 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 661
DIDEC H+C ND+ C NL GG+DC CP G +C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 596 DIDECALRTHTCWNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRCS 655
Query: 662 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 721
VCSC++G + CRR CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQ
Sbjct: 656 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 715
Query: 722 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 781
CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R
Sbjct: 716 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 775
Query: 782 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 814
+GS W G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 776 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 808
Score = 63.5 bits (153), Expect = 7e-10
Identities = 50/192 (26%), Positives = 80/192 (41%), Gaps = 34/192 (17%)
Query: 635 NCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLF------- 687
+C C G + + WV + D C C+C++G V CRRM C N + D
Sbjct: 268 HCEKTCQVSGLLYRDQDSWV-DGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQ 326
Query: 688 CCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCR---CLQGEVDCWPLPCPDVECEFS 744
CC C P+ C++ G+ L ++C++CR ++ C PL C + +
Sbjct: 327 CCKVCRPK----CIY-GGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKD---H 378
Query: 745 ILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHI 804
ILPEN+CC C A+ + C +W T C+CK+G+I
Sbjct: 379 ILPENQCCRVCRGHNFCAEGPKCGENSEC-----------KNWNTKAT----CECKSGYI 423
Query: 805 CCSVDPQCLQEL 816
D +++
Sbjct: 424 SVQGDSAYCEDI 435
>gi|222352166 nel-like 1 isoform 2 precursor [Homo sapiens]
Length = 763
Score = 929 bits (2400), Expect = 0.0
Identities = 420/813 (51%), Positives = 545/813 (67%), Gaps = 60/813 (7%)
Query: 5 VLLRTFCLIFGLGAVWGLGVDPSLQIDVLTELELGESTTGVRQVPGLHNGTKAFLFQDTP 64
+L+ FC+ V G G+DP LQ+D++TEL+L +T GV QV G+HN +KAFLFQD
Sbjct: 6 ILVVWFCVCTARTVV-GFGMDPDLQMDIVTELDLVNTTLGVAQVSGMHNASKAFLFQDIE 64
Query: 65 RSIKASTATAEQFFQKLRNKHEFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNE 124
R I A+ +E+ Q RNK EFTIL T++Q SGVILSI L+H Y ELESSG R+E
Sbjct: 65 REIHAAPHVSEKLIQLFRNKSEFTILATVQQKPSTSGVILSIRELEHSYFELESSGLRDE 124
Query: 125 VRLHYRSGSHRPHTEVFPYILADDKWHKLSLAISASHLILHIDCNKIYERVVEKPSTDLP 184
+R HY +P TE PY +AD +WHK++L++SASHL+LH+DCN+IYERV++ P T+LP
Sbjct: 125 IRYHYIHNG-KPRTEALPYRMADGQWHKVALSVSASHLLLHVDCNRIYERVIDPPDTNLP 183
Query: 185 LGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMEL 244
G WLGQRN HG FKGI+QD +++ MP G+I QCP+LN TCPTC+DF LVQ IM+L
Sbjct: 184 PGINLWLGQRNQKHGLFKGIIQDGKIIFMPNGYITQCPNLNHTCPTCSDFLSLVQGIMDL 243
Query: 245 QDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDG--CKNCTCLNGTIQ 302
Q++LAK +AKL+ AE R+++L+ C+CE+TC + G YR+ +SW+DG C+NCTC +G ++
Sbjct: 244 QELLAKMTAKLNYAETRLSQLENCHCEKTCQVSGLLYRDQDSWVDGDHCRNCTCKSGAVE 303
Query: 303 CETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECK 362
C + CP +C S ++ G+CCK C+ C + G+ EG+R S EC+
Sbjct: 304 CRRMSCPPLNCSPDSLPVHIAGQCCKVCRPKCIYGGKVLAEGQRILTKSCR------ECR 357
Query: 363 DQTM-KLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAV 421
+ K+ E CP L+C E I + CC+VC+G++FC+E C ENS C+N N +A
Sbjct: 358 GGVLVKITEM--CPPLNCSEKDHILPENQCCRVCRGHNFCAEGPKCGENSECKNWNTKAT 415
Query: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT 481
C C+ G+ +++ D+AYCEDIDECA HYC NT+CVN PG + C C GYIR+DD+SCT
Sbjct: 416 CECKSGYISVQGDSAYCEDIDECAAKMHYCHANTVCVNLPGLYRCDCVPGYIRVDDFSCT 475
Query: 482 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVC 541
EHDEC + QHNCDENA+C NTV GH+C CKPGY GNGT C+AFC++GCR GG C+A N C
Sbjct: 476 EHDECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICRAFCEEGCRYGGTCVAPNKC 535
Query: 542 ACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 601
CP GFTG CE DIDEC+ C + + CINL G + C C PSG S
Sbjct: 536 VCPSGFTGSHCEKDIDECALRTHTCWNDSACINLAGGFDCLC-----------PSGPS-- 582
Query: 602 DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS 661
C+GDC H+G +KHNGQ+W L+ DRCS
Sbjct: 583 ----------------------------------CSGDCPHEGGLKHNGQVWTLKEDRCS 608
Query: 662 VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQ 721
VCSC++G + CRR CDC+NP+ DLFCCPECD R++SQCL QNG LY SGD W +CQQ
Sbjct: 609 VCSCKDGKIFCRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHKLYRSGDNWTHSCQQ 668
Query: 722 CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR 781
CRCL+GEVDCWPL CP++ CE++ + E ECCPRCV+DPC AD I DI KTCLD V R
Sbjct: 669 CRCLEGEVDCWPLTCPNLSCEYTAILEGECCPRCVSDPCLADNITYDIRKTCLDSYGVSR 728
Query: 782 FTGSSWIKHGTECTLCQCKNGHICCSVDPQCLQ 814
+GS W G+ CT C+CKNG +CCSVD +CLQ
Sbjct: 729 LSGSVWTMAGSPCTTCKCKNGRVCCSVDFECLQ 761
Score = 63.5 bits (153), Expect = 7e-10
Identities = 50/192 (26%), Positives = 80/192 (41%), Gaps = 34/192 (17%)
Query: 635 NCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLF------- 687
+C C G + + WV + D C C+C++G V CRRM C N + D
Sbjct: 268 HCEKTCQVSGLLYRDQDSWV-DGDHCRNCTCKSGAVECRRMSCPPLNCSPDSLPVHIAGQ 326
Query: 688 CCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCR---CLQGEVDCWPLPCPDVECEFS 744
CC C P+ C++ G+ L ++C++CR ++ C PL C + +
Sbjct: 327 CCKVCRPK----CIY-GGKVLAEGQRILTKSCRECRGGVLVKITEMCPPLNCSEKD---H 378
Query: 745 ILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHI 804
ILPEN+CC C A+ + C +W T C+CK+G+I
Sbjct: 379 ILPENQCCRVCRGHNFCAEGPKCGENSEC-----------KNWNTKAT----CECKSGYI 423
Query: 805 CCSVDPQCLQEL 816
D +++
Sbjct: 424 SVQGDSAYCEDI 435
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 166 bits (421), Expect = 6e-41
Identities = 136/474 (28%), Positives = 187/474 (39%), Gaps = 75/474 (15%)
Query: 343 EGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCS 402
E ERN + G CV + G DCP H+++ S + C + CS
Sbjct: 1161 ECERNPLLCRGGTCV------------NTEGSFQCDCPLGHELSPSR---EDCVDINECS 1205
Query: 403 ERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPG 462
N N C N+ CSC G++A D C DIDEC C +T C N+ G
Sbjct: 1206 LSDNLCRNGKCVNMIGTYQCSCNPGYQA-TPDRQGCTDIDECMIMNGGC--DTQCTNSEG 1262
Query: 463 SFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTC 521
S+ C C GY + D SC + DEC N CD C N G + C+C G+ +
Sbjct: 1263 SYECSCSEGYALMPDGRSCADIDECENNPDICD-GGQCTNIPGEYRCLCYDGFMASMDMK 1321
Query: 522 KAFCKDGC-RNGGACI--------AANVCACPQGFT---GPSCETDIDECSDGFVQCDSR 569
+ C N C+ + +C C G++ G + TD+DEC G CD
Sbjct: 1322 TCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHNCDMH 1381
Query: 570 ANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR 629
A+C+N+PG + C CR+G+ NG+ C D+DEC G H C+ + C N G Y C
Sbjct: 1382 ASCLNIPGSFKCSCREGWIGNGI------KCIDLDECSNGTHQCSINAQCVNTPGSYRCA 1435
Query: 630 CPHGKNCTG-------DCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENP 682
C G G +C + + NGQ L C C+ GF P
Sbjct: 1436 CSEGFTGDGFTCSDVDECAENINLCENGQ--CLNVPGAYRCECEMGF-----------TP 1482
Query: 683 TVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQG-EVDCWPLPCPDV-E 740
D C + D +C QN + + C C G E+D C D+ E
Sbjct: 1483 ASDSRSCQDID-----ECSFQNICVFGTCNN--LPGMFHCICDDGYELDRTGGNCTDIDE 1535
Query: 741 CEFSILPENECC---PRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHG 791
C I N C P C D N C+D G+ ++K G
Sbjct: 1536 CADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNR-----VGNCYLKFG 1584
Score = 164 bits (415), Expect = 3e-40
Identities = 104/299 (34%), Positives = 137/299 (45%), Gaps = 26/299 (8%)
Query: 393 KVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCR 452
K C + C N C N +C C+ G+ ++++ C D+DEC G H C
Sbjct: 1321 KTCIDVNECDLNSNICMFGECENTKGSFICHCQLGY-SVKKGTTGCTDVDECEIGAHNCD 1379
Query: 453 ENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKP 512
+ C+N PGSF C C+ G+I + C + DEC H C NA C NT G + C C
Sbjct: 1380 MHASCLNIPGSFKCSCREGWIG-NGIKCIDLDECSNGTHQCSINAQCVNTPGSYRCACSE 1438
Query: 513 GYTGNGTTCKAF--CKDG---CRNGGACI---AANVCACPQGFT----GPSCETDIDECS 560
G+TG+G TC C + C N G C+ A C C GFT SC+ DIDECS
Sbjct: 1439 GFTGDGFTCSDVDECAENINLCEN-GQCLNVPGAYRCECEMGFTPASDSRSCQ-DIDECS 1496
Query: 561 DGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICF 620
F C NLPG +HC C DGY +G +C DIDEC +C N +C
Sbjct: 1497 --FQNICVFGTCNNLPGMFHCICDDGYE----LDRTGGNCTDIDEC-ADPINCVNG-LCV 1548
Query: 621 NLDGGYDCRCP--HGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC 677
N G Y+C CP N TG D +V + + D C+ + G + R C
Sbjct: 1549 NTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNTEIGVGVSRSSCC 1607
Score = 139 bits (350), Expect = 1e-32
Identities = 89/289 (30%), Positives = 127/289 (43%), Gaps = 25/289 (8%)
Query: 399 DFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCV 458
D C E N +C N C C GF + + CEDIDEC+ G + C+ N C+
Sbjct: 1810 DECKEIPGICANGVCINQIGSFRCECPTGF-SYNDLLLVCEDIDECSNGDNLCQRNADCI 1868
Query: 459 NTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNG 518
N+PGS+ C C G+ + +C + +EC+ + C + LC + G + C+C G+ +
Sbjct: 1869 NSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVC-SHGLCVDLQGSYQCICHNGFKASQ 1927
Query: 519 TTCKAFCKDGCR----NGGAC---IAANVCACPQGF--TGPSCETDIDECSDGFVQCDSR 569
D C G C + + C C GF T + DIDECS F Q
Sbjct: 1928 DQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRN 1987
Query: 570 ANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR 629
C N G + C C +GY +P G++C D +EC SC+ T C NL+G + C
Sbjct: 1988 GRCFNEIGSFKCLCNEGYE----LTPDGKNCIDTNECVALPGSCSPGT-CQNLEGSFRCI 2042
Query: 630 CPHG-----KNC--TGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVM 671
CP G +NC +C D + G C C GFV+
Sbjct: 2043 CPPGYEVKSENCIDINECDEDPNICLFGS--CTNTPGGFQCLCPPGFVL 2089
Score = 135 bits (341), Expect = 1e-31
Identities = 103/322 (31%), Positives = 132/322 (40%), Gaps = 63/322 (19%)
Query: 401 CSERHNCMENSI-----CRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCR-EN 454
C + + C +N + C N C+C G+ ALRED C+D+DECAEG H C
Sbjct: 2251 CEDINECAQNPLLCAFRCMNTFGSYECTCPIGY-ALREDQKMCKDLDECAEGLHDCESRG 2309
Query: 455 TMCVNTPGSFMCICKTGYI-RIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPG 513
MC N G+FMCIC G R D C + +EC T C EN C N +G + C C G
Sbjct: 2310 MMCKNLIGTFMCICPPGMARRPDGEGCVDENECRTKPGIC-ENGRCVNIIGSYRCECNEG 2368
Query: 514 Y--TGNGTTC-------------KAFCK------------DGCRNGGACIAANVCACPQG 546
+ + +GT C + C+ + C +GG CP
Sbjct: 2369 FQSSSSGTECLDNRQGLCFAEVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLP 2428
Query: 547 FT---------GPSCET---DIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFS 594
T GP T DIDEC C + CIN G + C C+ GY +
Sbjct: 2429 GTAQYKKICPHGPGYTTDGRDIDECKVMPNLC-TNGQCINTMGSFRCFCKVGYTTD---- 2483
Query: 595 PSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPH-------GKNCTGDCIHDGKVK 647
SG SC D+DEC C + IC N +G Y C CP GK C D +
Sbjct: 2484 ISGTSCIDLDECSQSPKPC--NYICKNTEGSYQCSCPRGYVLQEDGKTCK-DLDECQTKQ 2540
Query: 648 HNGQIWVLENDRCSVCSCQNGF 669
HN Q + C C GF
Sbjct: 2541 HNCQFLCVNTLGGFTCKCPPGF 2562
Score = 133 bits (334), Expect = 8e-31
Identities = 89/280 (31%), Positives = 132/280 (47%), Gaps = 34/280 (12%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C D CS+ N IC+N CSC G+ L+ED C+D+DEC +H C+
Sbjct: 2489 CIDLDECSQSPKPC-NYICKNTEGSYQCSCPRGY-VLQEDGKTCKDLDECQTKQHNCQ-- 2544
Query: 455 TMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY 514
+CVNT G F C C G+ + +C +++EC + C +C NT G +C C+ G+
Sbjct: 2545 FLCVNTLGGFTCKCPPGFTQ-HHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGF 2603
Query: 515 T--GNGTTCKAF--------CKDGCRNGGACIAANVCACPQG----FTGPSCETDIDECS 560
+ G C+ C+ GC+N + C CPQG + C D +ECS
Sbjct: 2604 SLDATGLNCEDVDECDGNHRCQHGCQN---ILGGYRCGCPQGYIQHYQWNQC-VDENECS 2659
Query: 561 DGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICF 620
+ C S A+C N G Y C C G+ F +C D++EC + ++ C + C
Sbjct: 2660 NPNA-CGS-ASCYNTLGSYKCACPSGF----SFDQFSSACHDVNECSSSKNPC--NYGCS 2711
Query: 621 NLDGGYDCRCPHG--KNCTGDCIHDGKVKHNGQIWVLEND 658
N +GGY C CP G + G C+ G + GQ L+ +
Sbjct: 2712 NTEGGYLCGCPPGYYRVGQGHCV-SGMGFNKGQYLSLDTE 2750
Score = 132 bits (331), Expect = 2e-30
Identities = 126/467 (26%), Positives = 173/467 (37%), Gaps = 97/467 (20%)
Query: 338 GRTYFEGERNTVYSSSGVCVLYECKDQ--TMKLVESSGCPALDCPESHQITLSHSCCKVC 395
GR +++ + N + G+C +C++ + K +SG ALD E + C
Sbjct: 1067 GRPFYK-DINECKAFPGMCTYGKCRNTIGSFKCRCNSGF-ALDMEERN-----------C 1113
Query: 396 KGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENT 455
D C + + IC N C C +G+ + C DIDEC CR T
Sbjct: 1114 TDIDECRISPDLCGSGICVNTPGSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGT 1173
Query: 456 MCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY 514
CVNT GSF C C G+ + C + +EC + + C N C N +G + C C PGY
Sbjct: 1174 -CVNTEGSFQCDCPLGHELSPSREDCVDINECSLSDNLC-RNGKCVNMIGTYQCSCNPGY 1231
Query: 515 --TGNGTTCKAFCKDGCRNGGA---CI---AANVCACPQGFT----GPSCETDIDECSDG 562
T + C + NGG C + C+C +G+ G SC DIDEC +
Sbjct: 1232 QATPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC-ADIDECENN 1290
Query: 563 FVQCDSRANCINLPGWYHCECRDGY----------------------------HDNGMF- 593
CD C N+PG Y C C DG+ + G F
Sbjct: 1291 PDICDG-GQCTNIPGEYRCLCYDGFMASMDMKTCIDVNECDLNSNICMFGECENTKGSFI 1349
Query: 594 ---------SPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDG 644
C D+DEC G H+C C N+ G + C C G G D
Sbjct: 1350 CHCQLGYSVKKGTTGCTDVDECEIGAHNCDMHASCLNIPGSFKCSCREGWIGNGIKCIDL 1409
Query: 645 KVKHNGQIWVLENDRC------SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSS 698
NG N +C C+C GF T D F C + D +
Sbjct: 1410 DECSNGTHQCSINAQCVNTPGSYRCACSEGF-------------TGDGFTCSDVDECAEN 1456
Query: 699 QCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCW-PLPCPDV-ECEF 743
L +NG+ L V +C C G C D+ EC F
Sbjct: 1457 INLCENGQCLN------VPGAYRCECEMGFTPASDSRSCQDIDECSF 1497
Score = 126 bits (316), Expect = 9e-29
Identities = 116/404 (28%), Positives = 171/404 (42%), Gaps = 74/404 (18%)
Query: 437 YCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDE 495
+ +DI+EC C C NT GSF C C +G+ + +++ +CT+ DEC + C
Sbjct: 1070 FYKDINECKAFPGMCTYGK-CRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCG- 1127
Query: 496 NALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDG---------CRNGGACIAAN---VCAC 543
+ +C NT G C C GY +G C D CR GG C+ C C
Sbjct: 1128 SGICVNTPGSFECECFEGYE-SGFMMMKNCMDIDECERNPLLCR-GGTCVNTEGSFQCDC 1185
Query: 544 PQGFT-GPSCE--TDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
P G PS E DI+ECS C + C+N+ G Y C C GY +P + C
Sbjct: 1186 PLGHELSPSREDCVDINECSLSDNLCRN-GKCVNMIGTYQCSCNPGYQA----TPDRQGC 1240
Query: 601 EDIDECGTGRHSCANDTICFNLDGGYDCRC-------PHGKNCTG--DCIHDGKVKHNGQ 651
DIDEC C DT C N +G Y+C C P G++C +C ++ + GQ
Sbjct: 1241 TDIDECMIMNGGC--DTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQ 1298
Query: 652 IWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNS 711
+ + C C +GF+ M +D+ ECD S+ C+ E N+
Sbjct: 1299 CTNIPGEYR--CLCYDGFMASMDM-----KTCIDV---NECDLN-SNICMFGECE---NT 1344
Query: 712 GDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITK 771
+++ +CQ L V C DV D C+ D+
Sbjct: 1345 KGSFICHCQ----LGYSVKKGTTGCTDV------------------DECEIGAHNCDMHA 1382
Query: 772 TCLDEMNVVRFT-GSSWIKHGTECT-LCQCKNGHICCSVDPQCL 813
+CL+ + + WI +G +C L +C NG CS++ QC+
Sbjct: 1383 SCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCV 1426
Score = 119 bits (299), Expect = 9e-27
Identities = 120/423 (28%), Positives = 162/423 (38%), Gaps = 86/423 (20%)
Query: 393 KVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCR 452
+ C D C + +N C N + C C GF L D C D DEC + C
Sbjct: 571 QACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFE-LTTDGKNCVDHDECTT-TNMCL 628
Query: 453 ENTMCVNTPGSFMCICKTGYIRI-DDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCK 511
N MC+N GSF CICK G++ + CT+ DEC T N C N+ G C C
Sbjct: 629 -NGMCINEDGSFKCICKPGFVLAPNGRYCTDVDECQT--PGICMNGHCINSEGSFRCDCP 685
Query: 512 PGYT--GNGTTC-----KAFCKDGCRNG-------GACIAAN-VCACPQGFTGPSCE--- 553
PG +G C ++ C G + G GA + CA P G C+
Sbjct: 686 PGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCP 745
Query: 554 ---------------------TDIDECSDGFVQCDSRAN--CINLPGWYHCECRDGYHDN 590
DI+EC+ + D AN C NL G Y C C GY +
Sbjct: 746 AKNSAEFHGLCSSGVGITVDGRDINECA---LDPDICANGICENLRGSYRCNCNSGYEPD 802
Query: 591 GMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNG 650
SG +C DIDEC R C N +C N G Y C CP G + + +
Sbjct: 803 A----SGRNCIDIDECLVNRLLCDNG-LCRNTPGSYSCTCPPG------YVFRTETETCE 851
Query: 651 QIWVLENDRCSVCSCQNGFVMCRRMVCDC----ENPTVDLFCCPECDPRL-----SSQC- 700
I E++ C +C+N C+C + + L C S+C
Sbjct: 852 DINECESNPCVNGACRNNL---GSFNCECSPGSKLSSTGLICIDSLKGTCWLNIQDSRCE 908
Query: 701 LHQNGETLYNS-----GDTWVQNCQQCR----CLQGEVDCWPLPCPDV-ECEF--SILPE 748
++ NG TL + G W C++C C +G + C DV ECE + P
Sbjct: 909 VNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVFPGVCPN 968
Query: 749 NEC 751
C
Sbjct: 969 GRC 971
Score = 117 bits (292), Expect = 6e-26
Identities = 118/458 (25%), Positives = 168/458 (36%), Gaps = 99/458 (21%)
Query: 385 ITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDEC 444
++ S CC + K + + C + +C +GFR EDIDEC
Sbjct: 1601 VSRSSCCCSLGKAWG-----NPCETCPPVNSTEYYTLCPGGEGFRP-NPITIILEDIDEC 1654
Query: 445 AEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS-CTEHDECITNQHNCDENALCFNTV 503
E C+ C+NT GSF C C GY +D C + DEC + C C+NT+
Sbjct: 1655 QELPGLCQGGN-CINTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGT-CYNTL 1712
Query: 504 GGHNCVCKPGY-------------------TGNGTTC--------------------KAF 524
G + C+C P Y + NGTTC KA+
Sbjct: 1713 GNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAW 1772
Query: 525 CK--DGCRNGGACIAANVCACPQGFT---GPSCETDIDECSDGFVQCDSRANCINLPGWY 579
K + C G +C GFT DIDEC + C + CIN G +
Sbjct: 1773 NKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGIC-ANGVCINQIGSF 1831
Query: 580 HCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCT-- 637
CEC G+ N + CEDIDEC G + C + C N G Y C C G +
Sbjct: 1832 RCECPTGFSYNDLLL----VCEDIDECSNGDNLCQRNADCINSPGSYRCECAAGFKLSPN 1887
Query: 638 ------GDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVM------------CRRMVC-- 677
+C+ V +G L+ C C NGF C R C
Sbjct: 1888 GACVDRNECLEIPNVCSHGLCVDLQGS--YQCICHNGFKASQDQTMCMDVDECERHPCGN 1945
Query: 678 -DCENP--TVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPL 734
C+N + + C P + ++ CL + + Q C+ RC E+ +
Sbjct: 1946 GTCKNTVGSYNCLCYPGFELTHNNDCL-----DIDECSSFFGQVCRNGRCF-NEIGSFKC 1999
Query: 735 PCPDVECEFSILPENECC---PRCVTDP--CQADTIRN 767
C + + + P+ + C CV P C T +N
Sbjct: 2000 LCNE---GYELTPDGKNCIDTNECVALPGSCSPGTCQN 2034
Score = 108 bits (269), Expect = 3e-23
Identities = 146/613 (23%), Positives = 214/613 (34%), Gaps = 157/613 (25%)
Query: 292 KNCTCLN--GTIQCETL----ICPNPDCPLKSALAYVDGKC----CKECKSICQFQGRTY 341
+N C+N G+ +CE + PN C ++ + C C + + Q
Sbjct: 1863 RNADCINSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNG 1922
Query: 342 FEGERN-TVYSSSGVCVLYECKDQTMK---------------LVESSGCPALDCPESH-- 383
F+ ++ T+ C + C + T K L ++ C +D S
Sbjct: 1923 FKASQDQTMCMDVDECERHPCGNGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFG 1982
Query: 384 QITLSHSC--------CKVCKGYDFCSERHNCMENS------------ICRNLNDRAVCS 423
Q+ + C C +GY+ + NC++ + C+NL C
Sbjct: 1983 QVCRNGRCFNEIGSFKCLCNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCI 2042
Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDD-YSC-- 480
C G+ E+ C DI+EC E + C + C NTPG F C+C G++ D+ C
Sbjct: 2043 CPPGYEVKSEN---CIDINECDEDPNICLFGS-CTNTPGGFQCLCPPGFVLSDNGRRCFD 2098
Query: 481 TEHDECITNQHNCDENALC-----FNTVGGHNCVCKPGYTGNGTTCKAFCKD-------- 527
T C TN EN C FNT C K G G C+ KD
Sbjct: 2099 TRQSFCFTN----FENGKCSVPKAFNTTKAKCCCSKMPGEGWGDPCELCPKDDEVAFQDL 2154
Query: 528 -------------------------GCRNGGACIAAN---VCACPQG----FTGPSCETD 555
G + G CI + C CP G +TG C D
Sbjct: 2155 CPYGHGTVPSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRC-VD 2213
Query: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 615
DECS G C N+ G + C C +G+ M +CEDI+EC CA
Sbjct: 2214 TDECSIG--NPCGNGTCTNVIGSFECNCNEGFEPGPMM-----NCEDINECAQNPLLCA- 2265
Query: 616 DTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS--VCSCQNGFVMCR 673
C N G Y+C CP G D Q + D C+ + C++ +MC+
Sbjct: 2266 -FRCMNTFGSYECTCPIGYALRED-----------QKMCKDLDECAEGLHDCESRGMMCK 2313
Query: 674 RMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNC------QQCRCLQG 727
++ T C P R + E G C +C C +G
Sbjct: 2314 NLI-----GTFMCICPPGMARRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEG 2368
Query: 728 EVDCWPLPCPDVECEFSILPENECCPRCVTDPCQ-ADTIRNDITKT--CLDEMNVVRFTG 784
+ EC + + C + CQ A + RN +TK+ C D G
Sbjct: 2369 ----FQSSSSGTECLDN--RQGLCFAEVLQTICQMASSSRNLVTKSECCCD-------GG 2415
Query: 785 SSWIKHGTECTLC 797
W G +C LC
Sbjct: 2416 RGW---GHQCELC 2425
Score = 107 bits (268), Expect = 3e-23
Identities = 104/366 (28%), Positives = 140/366 (38%), Gaps = 61/366 (16%)
Query: 291 CKNCTCLN--GTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNT 348
C N C+N G+ +C DCP A+ +DG+ C + R+T
Sbjct: 668 CMNGHCINSEGSFRC--------DCPPGLAVG-MDGRVCVDTHM-------------RST 705
Query: 349 VYSS--SGVCVLYE----------CKDQTMKLVES-SGCPALDCPESHQITLSHSCCKVC 395
Y GVCV C + E CPA + E H + S V
Sbjct: 706 CYGGIKKGVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLCSSGVGITV- 764
Query: 396 KGYDF--CSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRE 453
G D C+ + N IC NL C+C G+ C DIDEC R C +
Sbjct: 765 DGRDINECALDPDICANGICENLRGSYRCNCNSGYEP-DASGRNCIDIDECLVNRLLC-D 822
Query: 454 NTMCVNTPGSFMCICKTGYI-RIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKP 512
N +C NTPGS+ C C GY+ R + +C + +EC +N C N C N +G NC C P
Sbjct: 823 NGLCRNTPGSYSCTCPPGYVFRTETETCEDINECESNP--C-VNGACRNNLGSFNCECSP 879
Query: 513 GYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANC 572
G + T G CI + C CE +I+ + C +
Sbjct: 880 GSKLSST------------GLICIDSLKGTCWLNIQDSRCEVNINGATLKSECCATLGAA 927
Query: 573 INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPH 632
P CE D G+ G +CED++EC C N C N G + C CP
Sbjct: 928 WGSP-CERCEL-DTACPRGLARIKGVTCEDVNECEVFPGVCPNGR-CVNSKGSFHCECPE 984
Query: 633 GKNCTG 638
G G
Sbjct: 985 GLTLDG 990
Score = 92.0 bits (227), Expect = 2e-18
Identities = 67/208 (32%), Positives = 91/208 (43%), Gaps = 26/208 (12%)
Query: 439 EDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENAL 498
+ ID C + C N C+ T S+ C C GY + + C + DEC +N C N
Sbjct: 493 QTIDICKHHANLCL-NGRCIPTVSSYRCECNMGYKQDANGDCIDVDECTSNP--C-TNGD 548
Query: 499 CFNTVGGHNCVCKPGYTGNGTTCKAFCKDGC-RNG-----GACIAAN---VCACPQGF-- 547
C NT G + C C G+ T D C +NG G C+ + C C GF
Sbjct: 549 CVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTDGSFQCICNAGFEL 608
Query: 548 --TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDE 605
G +C D DEC+ CIN G + C C+ G+ + +P+G C D+DE
Sbjct: 609 TTDGKNC-VDHDECTT--TNMCLNGMCINEDGSFKCICKPGF----VLAPNGRYCTDVDE 661
Query: 606 CGTGRHSCANDTICFNLDGGYDCRCPHG 633
C T C N C N +G + C CP G
Sbjct: 662 CQT-PGICMNGH-CINSEGSFRCDCPPG 687
Score = 87.8 bits (216), Expect = 4e-17
Identities = 79/297 (26%), Positives = 107/297 (36%), Gaps = 77/297 (25%)
Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEH 483
C G++ L N I + G +C MC + G C + I+
Sbjct: 97 CCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISSTCGSKSIQ--------- 147
Query: 484 DECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTC-KAFCKDGCRNGGACIAANVCA 542
C + T +C C+ GY G T C + C++GC+NGG CI N CA
Sbjct: 148 --------QCSVRCMNGGTCADDHCQCQKGYIG--TYCGQPVCENGCQNGGRCIGPNRCA 197
Query: 543 CPQGFTGPSCETDI----------DECSDG---FVQCDSRANCINL-PGWYH-CE----- 582
C GFTGP CE D ++ G + C C + W H CE
Sbjct: 198 CVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 257
Query: 583 ---CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG---KNC 636
CR G+ N +C+D+DEC C C N G ++CRCP G
Sbjct: 258 PQPCRRGFIPNIRTG----ACQDVDECQAIPGICQGGN-CINTVGSFECRCPAGHKQSET 312
Query: 637 TGDCIHDGKVKHNGQIWVLENDRCSVCS--CQNGFVMCRRMVCDCENPTVDLFC-CP 690
T C + D CS+ C+ G +C N FC CP
Sbjct: 313 TQKC--------------EDIDECSIIPGICETG---------ECSNTVGSYFCVCP 346
Score = 79.7 bits (195), Expect = 1e-14
Identities = 97/388 (25%), Positives = 132/388 (34%), Gaps = 101/388 (26%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C+ D C + C N C C G + E CEDIDEC+ C E
Sbjct: 274 CQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQ-SETTQKCEDIDECSIIPGIC-ET 331
Query: 455 TMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHN-CDE---NALCFNTVGGH---- 506
C NT GS+ C+C GY+ + T+ CI + C N C + G
Sbjct: 332 GECSNTVGSYFCVCPRGYV-----TSTDGSRCIDQRTGMCFSGLVNGRCAQELPGRMTKM 386
Query: 507 NCVCKPGYT-GNGTTCKA-----------FCKDGCRNGGACIAANVCACP-----QGFTG 549
C C+PG G GT +A C DG GG I + + P GF
Sbjct: 387 QCCCEPGRCWGIGTIPEACPVRGSEEYRRLCMDGLPMGG--IPGSAGSRPGGTGGNGFAP 444
Query: 550 PSCETDIDECSDGFVQ-------------------------------------CDSRAN- 571
GF+ C AN
Sbjct: 445 SGNGNGYGPGGTGFIPIPGGNGFSPGVGGAGVGAGGQGPIITGLTILNQTIDICKHHANL 504
Query: 572 -----CINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGY 626
CI Y CEC GY + + C D+DEC + + C N C N G Y
Sbjct: 505 CLNGRCIPTVSSYRCECNMGYKQD-----ANGDCIDVDECTS--NPCTNGD-CVNTPGSY 556
Query: 627 DCRCPHGKNCT---------GDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC 677
C+C G T +CI +G + NG+ + D C C GF +
Sbjct: 557 YCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGR--CVNTDGSFQCICNAGF----ELTT 610
Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNG 705
D +N VD C + L+ C++++G
Sbjct: 611 DGKN-CVDHDECTTTNMCLNGMCINEDG 637
Score = 65.1 bits (157), Expect = 3e-10
Identities = 77/288 (26%), Positives = 101/288 (35%), Gaps = 76/288 (26%)
Query: 389 HSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCED--IDECAE 446
HS C C G+ + C+ ICRN SC DGF + R + C I
Sbjct: 94 HSYC--CPGWKTLPGGNQCIV-PICRN-------SCGDGFCS-RPNMCTCSSGQISSTCG 142
Query: 447 GRHYCRENTMCVN--TPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVG 504
+ + + C+N T C C+ GYI + C ++ C C +G
Sbjct: 143 SKSIQQCSVRCMNGGTCADDHCQCQKGYIG----TYCGQPVC---ENGCQNGGRC---IG 192
Query: 505 GHNCVCKPGYTG----------------NGTTCKAFCKDGCRNGGACIAANVCA------ 542
+ C C G+TG N C+ G G C CA
Sbjct: 193 PNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQ-----GQLTGIVCTKTLCCATIGRAW 247
Query: 543 -------------CPQGFTGPSCET----DIDECSDGFVQCDSRANCINLPGWYHCECRD 585
C +GF P+ T D+DEC C NCIN G + C C
Sbjct: 248 GHPCEMCPAQPQPCRRGFI-PNIRTGACQDVDECQAIPGICQG-GNCINTVGSFECRCPA 305
Query: 586 GYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
G+ S + + CEDIDEC C C N G Y C CP G
Sbjct: 306 GHKQ----SETTQKCEDIDECSIIPGICETGE-CSNTVGSYFCVCPRG 348
Score = 63.5 bits (153), Expect = 7e-10
Identities = 59/223 (26%), Positives = 85/223 (38%), Gaps = 55/223 (24%)
Query: 294 CTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSS 353
C C G Q T N +C + +L K ICQ NT S
Sbjct: 2556 CKCPPGFTQHHTACIDNNECGSQPSLC--------GAKGICQ-----------NTPGS-- 2594
Query: 354 GVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSIC 413
+ C+ Q ++++G C+ D C H C C
Sbjct: 2595 -----FSCECQRGFSLDATGLN-------------------CEDVDECDGNHRCQHG--C 2628
Query: 414 RNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYI 473
+N+ C C G+ + N C D +EC+ + C NT GS+ C C +G+
Sbjct: 2629 QNILGGYRCGCPQGYIQHYQWN-QCVDENECSNPN--ACGSASCYNTLGSYKCACPSGF- 2684
Query: 474 RIDDYSCTEHD--ECITNQHNCDENALCFNTVGGHNCVCKPGY 514
D +S HD EC ++++ C N C NT GG+ C C PGY
Sbjct: 2685 SFDQFSSACHDVNECSSSKNPC--NYGCSNTEGGYLCGCPPGY 2725
Score = 50.4 bits (119), Expect = 6e-06
Identities = 67/241 (27%), Positives = 83/241 (34%), Gaps = 58/241 (24%)
Query: 396 KGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENT 455
K CS R CM C + + C C+ G+ YC C G C+
Sbjct: 144 KSIQQCSVR--CMNGGTCADDH----CQCQKGYIG-----TYCGQ-PVCENG---CQNGG 188
Query: 456 MCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHN--CD--------ENALCFNTVG- 504
C+ G C C G+ C T +N C LC T+G
Sbjct: 189 RCI---GPNRCACVYGFTGPQCERDYRTGPCFTQVNNQMCQGQLTGIVCTKTLCCATIGR 245
Query: 505 --GHNCV--------CKPGYTGNGTTCKAFCKDGCR------NGGACI---AANVCACPQ 545
GH C C+ G+ N T D C+ GG CI + C CP
Sbjct: 246 AWGHPCEMCPAQPQPCRRGFIPNIRTGACQDVDECQAIPGICQGGNCINTVGSFECRCPA 305
Query: 546 GF----TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE 601
G T CE DIDECS C++ C N G Y C C GY + S G C
Sbjct: 306 GHKQSETTQKCE-DIDECSIIPGICET-GECSNTVGSYFCVCPRGY----VTSTDGSRCI 359
Query: 602 D 602
D
Sbjct: 360 D 360
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 157 bits (397), Expect = 4e-38
Identities = 93/251 (37%), Positives = 120/251 (47%), Gaps = 24/251 (9%)
Query: 393 KVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCR 452
K C + C N + C N +C C G+ ++ C DI+EC G H C
Sbjct: 1276 KTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSG-KKGKTGCTDINECEIGAHNCG 1334
Query: 453 ENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKP 512
++ +C NT GSF C C G+I D CT+ DEC H C ++A C NT+G + C+CK
Sbjct: 1335 KHAVCTNTAGSFKCSCSPGWIG-DGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKE 1393
Query: 513 GYTGNGTTCKAF--CKDG---CRNGGACIAA---NVCACPQGFT----GPSCETDIDECS 560
GYTG+G TC C + C N G C+ A C C GF G +CE DIDECS
Sbjct: 1394 GYTGDGFTCTDLDECSENLNLCGN-GQCLNAPGGYRCECDMGFVPSADGKACE-DIDECS 1451
Query: 561 DGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICF 620
C NLPG + CEC GY SG +C D++EC +C + C
Sbjct: 1452 --LPNICVFGTCHNLPGLFRCECEIGYE----LDRSGGNCTDVNEC-LDPTTCISGN-CV 1503
Query: 621 NLDGGYDCRCP 631
N G Y C CP
Sbjct: 1504 NTPGSYICDCP 1514
Score = 150 bits (379), Expect = 5e-36
Identities = 151/556 (27%), Positives = 211/556 (37%), Gaps = 87/556 (15%)
Query: 288 IDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDG-KCCKECKSICQFQGRTYFEGER 346
ID C+ L G QC + D K Y G K C I + Q R
Sbjct: 1071 IDECRISPDLCGRGQC---VNTPGDFECKCDEGYESGFMMMKNCMDIDECQ--------R 1119
Query: 347 NTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHN 406
+ + GVC + G +CP HQ++ + S C + C +
Sbjct: 1120 DPLLCRGGVCH------------NTEGSYRCECPPGHQLSPNISACI---DINECELSAH 1164
Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMC 466
N C NL + C+C G+ + D +C DIDEC+ C T C N+ GS+ C
Sbjct: 1165 LCPNGRCVNLIGKYQCACNPGYHST-PDRLFCVDIDECSIMNGGCE--TFCTNSEGSYEC 1221
Query: 467 ICKTGYIRIDDY-SCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFC 525
C+ G+ + D SCT+ DEC N + CD C N G + C+C G+ +
Sbjct: 1222 SCQPGFALMPDQRSCTDIDECEDNPNICD-GGQCTNIPGEYRCLCYDGFMASEDMKTCVD 1280
Query: 526 KDGCR-NGGACIAAN--------VCACPQGFTGPSCET---DIDECSDGFVQCDSRANCI 573
+ C N C++ +C C G++G +T DI+EC G C A C
Sbjct: 1281 VNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIGAHNCGKHAVCT 1340
Query: 574 NLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
N G + C C G+ +G+ C D+DEC G H C+ C N G Y C C G
Sbjct: 1341 NTAGSFKCSCSPGWIGDGI------KCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEG 1394
Query: 634 K-----NCT--GDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFV-----MCRRMVCDCEN 681
CT +C + + NGQ L C C GFV + +C
Sbjct: 1395 YTGDGFTCTDLDECSENLNLCGNGQ--CLNAPGGYRCECDMGFVPSADGKACEDIDECSL 1452
Query: 682 PTVDLFCCPECDPRLSSQCLHQNGETLYNSGD--TWVQNC-QQCRCLQGEVDCWP----L 734
P + +F P L +C + G L SG T V C C+ G P
Sbjct: 1453 PNICVFGTCHNLPGL-FRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYIC 1511
Query: 735 PCPDVECEFSILPENECCPRCVTDPCQAD-TIRNDITKT-CLDEMNV-------VRFTGS 785
CP +F + P C + C D R D T C +E+ V G
Sbjct: 1512 DCPP---DFELNPTRVGCVDTRSGNCYLDIRPRGDNGDTACSNEIGVGVSKASCCCSLGK 1568
Query: 786 SWIKHGTECTLCQCKN 801
+W GT C +C N
Sbjct: 1569 AW---GTPCEMCPAVN 1581
Score = 145 bits (366), Expect = 1e-34
Identities = 140/482 (29%), Positives = 186/482 (38%), Gaps = 79/482 (16%)
Query: 291 CKNCTCLNGTIQCETLICPNPDCPLKSALAYVDG--KCCKECKSICQFQGRTYF------ 342
C TC N T+ T ICP PD V+G C +S+C R Y+
Sbjct: 1658 CGPGTCYN-TVGNYTCICP-PD------YMQVNGGNNCMDMRRSLCY---RNYYADNQTC 1706
Query: 343 EGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALD-----CPESHQITLSHSCCKVCKG 397
+GE + C Y K E P+ D C + +
Sbjct: 1707 DGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVD 1766
Query: 398 YDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMC 457
D C E EN +C N+ C C GF + CEDIDEC G C+ N C
Sbjct: 1767 IDECREIPGVCENGVCINMVGSFRCECPVGF-FYNDKLLVCEDIDECQNG-PVCQRNAEC 1824
Query: 458 VNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGN 517
+NT GS+ C CK GY C + +EC + C + C +TVG C+C G+ N
Sbjct: 1825 INTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNIC-SHGQCIDTVGSFYCLCHTGFKTN 1883
Query: 518 G--TTCKAF--C-KDGCRNGGA--CIAANVCACPQGFT---GPSCETDIDECSDGFVQCD 567
T C C +D C NG I + C C GF C D+DEC+ G
Sbjct: 1884 DDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDC-IDVDECASGNGNLC 1942
Query: 568 SRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYD 627
CIN G + C+C +GY +P G +C DI+EC CA T C NLDG Y
Sbjct: 1943 RNGQCINTVGSFQCQCNEGYE----VAPDGRTCVDINECLLEPRKCAPGT-CQNLDGSYR 1997
Query: 628 CRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRC-SVCSCQNGFVMCRRMVCDCENPTVDL 686
C CP G + L+N++C + C +C + C N
Sbjct: 1998 CICPPG-------------------YSLQNEKCEDIDECVEEPEIC--ALGTCSNTEGSF 2036
Query: 687 FC-CPE----------CDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRC-LQGEVDCWPL 734
C CPE C S C + +S + + Q+C C L+GE W
Sbjct: 2037 KCLCPEGFSLSSSGRRCQDLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGE--GWGD 2094
Query: 735 PC 736
PC
Sbjct: 2095 PC 2096
Score = 143 bits (361), Expect = 6e-34
Identities = 126/421 (29%), Positives = 169/421 (40%), Gaps = 62/421 (14%)
Query: 235 HGLVQKIMELQDILAKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNC 294
H +K ME ++++ QR + C E C K C+N
Sbjct: 2256 HDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGI----------CENG 2305
Query: 295 TCLN--GTIQCET----LICPNPDCPLKSALAYVDGKCCKEC-KSICQFQGRTYFEGERN 347
CLN G+ CE PN D L +G C E +++CQ RN
Sbjct: 2306 RCLNTRGSYTCECNDGFTASPNQD----ECLDNREGYCFTEVLQNMCQIGS-----SNRN 2356
Query: 348 TVYSSSGVCVLYECKDQTMKLVESSGCPALD--CPESHQITLSHSCCKVCKGYDFCSERH 405
V S C ++ G A CP + + D C H
Sbjct: 2357 PVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGA------DIDECKVIH 2410
Query: 406 NCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
+ N C N C C+ G+ + C D++EC + C N +C NT GS+
Sbjct: 2411 DVCRNGECVNDRGSYHCICKTGYTPDITGTS-CVDLNECNQAPKPC--NFICKNTEGSYQ 2467
Query: 466 CICKTGYIRIDD-YSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTC--K 522
C C GYI +D SC + DEC T QHNC LC NT+GG C C PG+T + T+C
Sbjct: 2468 CSCPKGYILQEDGRSCKDLDECATKQHNCQ--FLCVNTIGGFTCKCPPGFTQHHTSCIDN 2525
Query: 523 AFCKDG---CRNGGACI---AANVCACPQGF----TGPSCETDIDECSDGFVQCDSRANC 572
C C + G C + C C +GF TG SCE D+DEC +G +C C
Sbjct: 2526 NECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCE-DVDEC-EGNHRCQH--GC 2581
Query: 573 INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPH 632
N+ G Y C C GY + ++ C D +EC H C + C N G Y C CP
Sbjct: 2582 QNIIGGYRCSCPQGYLQHYQWN----QCVDENEC-LSAHICGGAS-CHNTLGSYKCMCPA 2635
Query: 633 G 633
G
Sbjct: 2636 G 2636
Score = 142 bits (358), Expect = 1e-33
Identities = 164/616 (26%), Positives = 227/616 (36%), Gaps = 140/616 (22%)
Query: 191 LGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILAK 250
LG +N G FK + P+GF L+ + C D + + AK
Sbjct: 2026 LGTCSNTEGSFK--------CLCPEGF-----SLSSSGRRCQD--------LRMSYCYAK 2064
Query: 251 -TSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICP 309
K S + R + +C C +KG E W D C+ +CP
Sbjct: 2065 FEGGKCSSPKSRNHSKQEC----CCALKG------EGWGDPCE--------------LCP 2100
Query: 310 N-PD------CPLKSAL------AYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVC 356
PD CP S + + VD CKE +C+ +G +
Sbjct: 2101 TEPDEAFRQICPYGSGIIVGPDDSAVDMDECKE-PDVCKHGQCINTDGSYRCECPFGYIL 2159
Query: 357 VLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYD-----FCSERHNCMENS 411
EC D T + + C C + C +G++ C + + C +N
Sbjct: 2160 AGNECVD-TDECSVGNPCGNGTCKN----VIGGFECTCEEGFEPGPMMTCEDINECAQNP 2214
Query: 412 I-----CRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTM-CVNTPGSFM 465
+ C N C C G+ LRED C+D DEC EG+H C E M C N G++M
Sbjct: 2215 LLCAFRCVNTYGSYECKCPVGY-VLREDRRMCKDEDECEEGKHDCTEKQMECKNLIGTYM 2273
Query: 466 CICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG--NGTTC- 521
CIC GY R D C + +EC T C EN C NT G + C C G+T N C
Sbjct: 2274 CICGPGYQRRPDGEGCVDENECQTKPGIC-ENGRCLNTRGSYTCECNDGFTASPNQDECL 2332
Query: 522 ---KAFC-----KDGCRNGGA---CIAANVCACPQG-FTGPSCE---------------- 553
+ +C ++ C+ G + + + C C G GP CE
Sbjct: 2333 DNREGYCFTEVLQNMCQIGSSNRNPVTKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPH 2392
Query: 554 --------TDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDE 605
DIDEC C C+N G YHC C+ GY + +G SC D++E
Sbjct: 2393 GRGFMTNGADIDECKVIHDVC-RNGECVNDRGSYHCICKTGYTPD----ITGTSCVDLNE 2447
Query: 606 CGTGRHSCANDTICFNLDGGYDCRCP-------HGKNCTGDCIHDGKVKHNGQIWVLEND 658
C C + IC N +G Y C CP G++C D +HN Q +
Sbjct: 2448 CNQAPKPC--NFICKNTEGSYQCSCPKGYILQEDGRSCK-DLDECATKQHNCQFLCVNTI 2504
Query: 659 RCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPE---CDPRLSS-QCLHQNGETLYNSGDT 714
C C GF D T D+ C C S C Q G +L +G +
Sbjct: 2505 GGFTCKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSS 2564
Query: 715 W--VQNCQ-QCRCLQG 727
V C+ RC G
Sbjct: 2565 CEDVDECEGNHRCQHG 2580
Score = 122 bits (306), Expect = 1e-27
Identities = 135/511 (26%), Positives = 189/511 (36%), Gaps = 102/511 (19%)
Query: 369 VESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGF 428
+ + G C +Q TL+ + C+ D C + N C N + C C GF
Sbjct: 505 INNQGSYTCQCRAGYQSTLTRT---ECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGF 561
Query: 429 RALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECI 487
R D CED+DEC+ R+ C N MC+N GSF CICK G+ + D C + +EC
Sbjct: 562 HVTR-DGKNCEDMDECSI-RNMCL-NGMCINEDGSFKCICKPGFQLASDGRYCKDINECE 618
Query: 488 TNQHNCDENALCFNTVGGHNCVCKPGYTG--NGTTC-----KAFCKDGCRNG-------G 533
T N C NT G + C C PG +G C ++ C G + G G
Sbjct: 619 T--PGICMNGRCVNTDGSYRCECFPGLAVGLDGRVCVDTHMRSTCYGGYKRGQCIKPLFG 676
Query: 534 ACIAANVCA-------------------------CPQGFTGPSCETDIDECSDGFVQCDS 568
A + C C G S +DI+EC+ C +
Sbjct: 677 AVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPN 736
Query: 569 RANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
C NL G Y C C GY +G++C DI+EC C N C N G + C
Sbjct: 737 -GICENLRGTYKCICNSGYE----VDSTGKNCVDINECVLNSLLCDNGQ-CRNTPGSFVC 790
Query: 629 RCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRR----MVCDCENPTV 684
CP G I+ +K I D C C NG +C+ +C+C + +
Sbjct: 791 TCPKG------FIYKPDLKTCEDI-----DECESSPCING--VCKNSPGSFICECSSEST 837
Query: 685 DLFCCPECDPRLSSQC----------LHQNGETLYNS-----GDTWVQNCQQCR----CL 725
C + C ++ NG TL + G W C C+ C
Sbjct: 838 LDPTKTICIETIKGTCWQTVIDGRCEININGATLKSQCCSSLGAAWGSPCTLCQVDPICG 897
Query: 726 QGEVDCWPLPCPDV-ECE-FSILPENECCPR---CVTDPCQADTIRNDITKTCLDEMNVV 780
+G C D+ ECE F + +N C C + + + CLD +
Sbjct: 898 KGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMTLDATGRICLD----I 953
Query: 781 RFTGSSWIKHGTECTL---CQCKNGHICCSV 808
R ECTL + + CCSV
Sbjct: 954 RLETCFLRYEDEECTLPIAGRHRMDACCCSV 984
Score = 115 bits (287), Expect = 2e-25
Identities = 94/349 (26%), Positives = 138/349 (39%), Gaps = 86/349 (24%)
Query: 289 DGCKNCTCLN--GTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGER 346
D C+N C+N G+ C IC P + + VD C + C F +
Sbjct: 2411 DVCRNGECVNDRGSYHC---ICKTGYTPDITGTSCVDLNECNQAPKPCNFICK------- 2460
Query: 347 NTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCS-ERH 405
NT S Y+C CP+ + + + CK D C+ ++H
Sbjct: 2461 NTEGS-------YQCS----------------CPKGY---ILQEDGRSCKDLDECATKQH 2494
Query: 406 NCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
NC +C N C C GF + + C D +EC + C +C NTPGSF
Sbjct: 2495 NCQ--FLCVNTIGGFTCKCPPGFT---QHHTSCIDNNECTSDINLCGSKGICQNTPGSFT 2549
Query: 466 CICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAF 524
C C+ G+ + SC + DEC N H C C N +GG+ C C GY + +
Sbjct: 2550 CECQRGFSLDQTGSSCEDVDECEGN-HRCQHG--CQNIIGGYRCSCPQGY------LQHY 2600
Query: 525 CKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECR 584
+ C + C++A++C A+C N G Y C C
Sbjct: 2601 QWNQCVDENECLSAHIC--------------------------GGASCHNTLGSYKCMCP 2634
Query: 585 DGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
G+ + C+DI+ECG+ + C+ C N +GGY C CP G
Sbjct: 2635 AGF----QYEQFSGGCQDINECGSAQAPCSYG--CSNTEGGYLCGCPPG 2677
Score = 114 bits (284), Expect = 5e-25
Identities = 120/483 (24%), Positives = 168/483 (34%), Gaps = 122/483 (25%)
Query: 291 CKNCTCLN--GTIQCET----------LICPN-------PDCPLKSALAYVDGKCCKECK 331
C+N C+N G+ +CE L+C + P C + G +CK
Sbjct: 1777 CENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQNGPVCQRNAECINTAGSYRCDCK 1836
Query: 332 SICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSC 391
+F T +RN +C +C D V S C L H+
Sbjct: 1837 PGYRFTS-TGQCNDRNECQEIPNICSHGQCIDT----VGSFYC------------LCHTG 1879
Query: 392 CKVCKGYDFCSERHNCME----NSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEG 447
K C + + C N CRN C C GF + N C D+DECA G
Sbjct: 1880 FKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGF--ILSHNNDCIDVDECASG 1937
Query: 448 RHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGH 506
N C+NT GSF C C GY + D +C + +EC+ C C N G +
Sbjct: 1938 NGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGT-CQNLDGSY 1996
Query: 507 NCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCA---------CPQGF----TGPSCE 553
C+C PGY+ C+ D C A C+ CP+GF +G C+
Sbjct: 1997 RCICPPGYSLQNEKCEDI--DECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQ 2054
Query: 554 T----------DIDECSDGFVQCDSRANC---INLPGWYH-CECRDGYHD---------- 589
+ +CS + S+ C + GW CE D
Sbjct: 2055 DLRMSYCYAKFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAFRQICPYG 2114
Query: 590 NGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTG-DCIHDGKVKH 648
+G+ +S D+DEC C N DG Y C CP G G +C+
Sbjct: 2115 SGIIVGPDDSAVDMDEC--KEPDVCKHGQCINTDGSYRCECPFGYILAGNECV------- 2165
Query: 649 NGQIWVLENDRCSV-----------------CSCQNGFVMCRRMVCD-----CENPTVDL 686
+ D CSV C+C+ GF M C+ +NP +
Sbjct: 2166 -------DTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPLLCA 2218
Query: 687 FCC 689
F C
Sbjct: 2219 FRC 2221
Score = 110 bits (274), Expect = 7e-24
Identities = 135/558 (24%), Positives = 192/558 (34%), Gaps = 153/558 (27%)
Query: 290 GCKN-CTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNT 348
GC+ CT G+ +C C + + D C++ +IC T GE
Sbjct: 1207 GCETFCTNSEGSYECS---CQPGFALMPDQRSCTDIDECEDNPNICDGGQCTNIPGEYRC 1263
Query: 349 VYSSSGVCVLYECKDQTMKLVESSGCPAL-DCPESHQITLSHSCCK-----VC------- 395
+ C D M + C + +C + I LS +C +C
Sbjct: 1264 L-----------CYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYS 1312
Query: 396 --KGYDFCSE-------RHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAE 446
KG C++ HNC ++++C N CSC G+ D C D+DEC+
Sbjct: 1313 GKKGKTGCTDINECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIG---DGIKCTDLDECSN 1369
Query: 447 GRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGH 506
G H C ++ C NT GS+ C+CK GY D ++CT+ DEC N + C N C N GG+
Sbjct: 1370 GTHMCSQHADCKNTMGSYRCLCKEGYTG-DGFTCTDLDECSENLNLCG-NGQCLNAPGGY 1427
Query: 507 NCVCKPGY--TGNGTTCKAF------------------------CKDGC---RNGGACIA 537
C C G+ + +G C+ C+ G R+GG C
Sbjct: 1428 RCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTD 1487
Query: 538 AN--------------------VCACPQGFT------------GPSCETDIDECSD-GFV 564
N +C CP F +C DI D G
Sbjct: 1488 VNECLDPTTCISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDT 1547
Query: 565 QCD-------SRANCINLPG--W-YHCECRDGYHDNG--MFSPSGES---------CEDI 603
C S+A+C G W CE + + + P GE EDI
Sbjct: 1548 ACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDI 1607
Query: 604 DECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVC 663
DEC C C N G + CRCP G D +V + V E + +C
Sbjct: 1608 DECQELPGLCQGGK-CINTFGSFQCRCPTGYYLN----EDTRVCDD----VNECETPGIC 1658
Query: 664 SCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQ--------NGETL------- 708
+ C C + + C S C +GE L
Sbjct: 1659 GPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTKKM 1718
Query: 709 ----YNSGDTWVQNCQQC 722
YN G W + C+QC
Sbjct: 1719 CCCSYNIGRAWNKPCEQC 1736
Score = 99.8 bits (247), Expect = 9e-21
Identities = 138/559 (24%), Positives = 203/559 (36%), Gaps = 157/559 (28%)
Query: 288 IDGCKNCTCLNGTIQCE--TLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGE 345
ID C++ C+NG + + IC +C +S L C + K C +T +G
Sbjct: 808 IDECESSPCINGVCKNSPGSFIC---ECSSESTLDPTKTICIETIKGTC---WQTVIDG- 860
Query: 346 RNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERH 405
+ +G + +C C +L S C +C+ C + +
Sbjct: 861 -RCEININGATLKSQC------------CSSLGAAWG-------SPCTLCQVDPICGKGY 900
Query: 406 NCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
+ ++ + C EDIDEC C+ N +CVNT GSF
Sbjct: 901 SRIKGTQC-------------------------EDIDECEVFPGVCK-NGLCVNTRGSFK 934
Query: 466 CICKTG------------------YIRIDDYSCT-------EHDECITN------QHNCD 494
C C +G ++R +D CT D C + C+
Sbjct: 935 CQCPSGMTLDATGRICLDIRLETCFLRYEDEECTLPIAGRHRMDACCCSVGAAWGTEECE 994
Query: 495 ENALCFNTVGGHNCVCKPGY-TGNGTTCKAFCKD--------------GCRNGGACIAAN 539
E + C PG+ T T K F KD CRN I +
Sbjct: 995 ECPMRNTPEYEELCPRGPGFATKEITNGKPFFKDINECKMIPSLCTHGKCRN---TIGSF 1051
Query: 540 VCACPQGFTGPSCE---TDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPS 596
C C GF S E TDIDEC C R C+N PG + C+C +GY M
Sbjct: 1052 KCRCDSGFALDSEERNCTDIDECRISPDLC-GRGQCVNTPGDFECKCDEGYESGFMMM-- 1108
Query: 597 GESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGD---CIHDGKVKHNGQIW 653
++C DIDEC C +C N +G Y C CP G + + CI + + + +
Sbjct: 1109 -KNCMDIDECQRDPLLCRGG-VCHNTEGSYRCECPPGHQLSPNISACIDINECELSAHL- 1165
Query: 654 VLENDRC------SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNG-- 705
N RC C+C G+ + T D C + D +C NG
Sbjct: 1166 -CPNGRCVNLIGKYQCACNPGY-----------HSTPDRLFCVDID-----ECSIMNGGC 1208
Query: 706 ETL-YNSGDTWVQNCQQCRCLQGEVDCWPLPCPDV-ECEF--SILPENECCP-----RCV 756
ET NS ++ +CQ L + C D+ ECE +I +C RC+
Sbjct: 1209 ETFCTNSEGSYECSCQPGFALMPD----QRSCTDIDECEDNPNICDGGQCTNIPGEYRCL 1264
Query: 757 TDPCQADTIRNDITKTCLD 775
C + ++ KTC+D
Sbjct: 1265 ---CYDGFMASEDMKTCVD 1280
Score = 92.4 bits (228), Expect = 1e-18
Identities = 68/202 (33%), Positives = 85/202 (42%), Gaps = 26/202 (12%)
Query: 442 DECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFN 501
D C R+ C +N C+ TPGS C C G+ C + DEC N E C N
Sbjct: 451 DYCQLVRYLC-QNGRCIPTPGSCRCECNKGFQLDLRGECIDVDECEKNPCAGGE---CIN 506
Query: 502 TVGGHNCVCKPGYTGNGTTCKAFCKDGCR------NGGACIAAN---VCACPQGF----T 548
G + C C+ GY T + D C N G CI + C C GF
Sbjct: 507 NQGSYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRD 566
Query: 549 GPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGT 608
G +CE D+DECS CIN G + C C+ G+ + G C+DI+EC T
Sbjct: 567 GKNCE-DMDECS--IRNMCLNGMCINEDGSFKCICKPGF----QLASDGRYCKDINECET 619
Query: 609 GRHSCANDTICFNLDGGYDCRC 630
C N C N DG Y C C
Sbjct: 620 -PGICMNGR-CVNTDGSYRCEC 639
Score = 85.9 bits (211), Expect = 1e-16
Identities = 70/262 (26%), Positives = 97/262 (37%), Gaps = 63/262 (24%)
Query: 396 KGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENT 455
KG + C R+N C G++ L N I + G +C
Sbjct: 54 KGPNVCGSRYNAY---------------CCPGWKTLPGGNQCIVPICRHSCGDGFCSRPN 98
Query: 456 MCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYT 515
MC G C + I+ + C C + +C+C+ GY
Sbjct: 99 MCTCPSGQIAPSCGSRSIQHCNIRCMNGGSCSDD-----------------HCLCQKGYI 141
Query: 516 GNGTTC-KAFCKDGCRNGGACIAANVCACPQGFTGPSCETDI----------DECSDG-- 562
G T C + C+ GC NGG C+A N CAC GFTGP CE D ++ G
Sbjct: 142 G--THCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVISNQMCQGQL 199
Query: 563 -FVQCDSRANCINL-PGWYH-CE--------CRDGYHDNGMFSPSGESCEDIDECGTGRH 611
+ C C + W H CE CR G+ N +C+D+DEC
Sbjct: 200 SGIVCTKTLCCATVGRAWGHPCEMCPAQPHPCRRGFIPNIRTG----ACQDVDECQAIPG 255
Query: 612 SCANDTICFNLDGGYDCRCPHG 633
C C N G ++C+CP G
Sbjct: 256 LCQGGN-CINTVGSFECKCPAG 276
Score = 55.5 bits (132), Expect = 2e-07
Identities = 42/143 (29%), Positives = 64/143 (44%), Gaps = 24/143 (16%)
Query: 572 CINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCP 631
CI PG CEC G+ GE C D+DEC ++ CA C N G Y C+C
Sbjct: 465 CIPTPGSCRCECNKGFQ----LDLRGE-CIDVDECE--KNPCAGGE-CINNQGSYTCQCR 516
Query: 632 HGKNCT---------GDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENP 682
G T +C+ +G++ +NG+ + D C C GF + R +CE
Sbjct: 517 AGYQSTLTRTECRDIDECLQNGRICNNGR--CINTDGSFHCVCNAGFHVTRDGK-NCE-- 571
Query: 683 TVDLFCCPECDPRLSSQCLHQNG 705
D+ C + L+ C++++G
Sbjct: 572 --DMDECSIRNMCLNGMCINEDG 592
Score = 53.9 bits (128), Expect = 6e-07
Identities = 47/188 (25%), Positives = 67/188 (35%), Gaps = 11/188 (5%)
Query: 294 CTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSI-CQFQGRTYFEGERNTVYSS 352
C C G Q T N +C L G C S C+ Q + ++
Sbjct: 2509 CKCPPGFTQHHTSCIDNNECTSDINLCGSKGICQNTPGSFTCECQRGFSLDQTGSSCEDV 2568
Query: 353 SGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSI 412
+ C+ ++ C CP+ + L H C + C H C S
Sbjct: 2569 DECEGNHRCQHGCQNIIGGYRC---SCPQGY---LQHYQWNQCVDENECLSAHICGGAS- 2621
Query: 413 CRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY 472
C N C C GF+ + + C+DI+EC + C C NT G ++C C GY
Sbjct: 2622 CHNTLGSYKCMCPAGFQ-YEQFSGGCQDINECGSAQAPCSYG--CSNTEGGYLCGCPPGY 2678
Query: 473 IRIDDYSC 480
RI C
Sbjct: 2679 FRIGQGHC 2686
Score = 52.0 bits (123), Expect = 2e-06
Identities = 140/628 (22%), Positives = 205/628 (32%), Gaps = 162/628 (25%)
Query: 267 QCYCERTCTMKGTTYREFESWIDG---CKNCTCLN--GTIQCETLICPNPDCPLKSALAY 321
+C C+ T G T + + + C N CLN G +CE C + +
Sbjct: 1388 RCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCE--------CDM-GFVPS 1438
Query: 322 VDGKCCK---ECK--SICQFQGRTY-----FEGERNTVYS---SSGVCV-LYECKDQTMK 367
DGK C+ EC +IC F G + F E Y S G C + EC D T
Sbjct: 1439 ADGKACEDIDECSLPNICVF-GTCHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTC 1497
Query: 368 L----VESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS 423
+ V + G DCP ++ + C + NC + R N CS
Sbjct: 1498 ISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRS-------GNCYLDIRPRGDNGDTACS 1550
Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMC--VNTPGSFMCICKTGY--------I 473
G + C+ G+ + MC VNT + +C G +
Sbjct: 1551 NEIGVGVSKASCC-------CSLGKAWGTPCEMCPAVNT-SEYKILCPGGEGFRPNPITV 1602
Query: 474 RIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGG 533
++D DEC C + C NT G C C GY N T + C G
Sbjct: 1603 ILEDI-----DECQELPGLC-QGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNECETPG 1656
Query: 534 AC--------IAANVCACPQGFT----GPSC-ETDIDECSDGFVQCDSRANCINLPGWYH 580
C + C CP + G +C + C + + + L
Sbjct: 1657 ICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSLCYRNYYADNQTCDGELLFNMTK 1716
Query: 581 CECRDGYHDNGMFSPSGESCE----------------------------DIDECGTGRHS 612
C Y+ ++ E C DIDEC
Sbjct: 1717 KMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPGFVIDIYTGLPVDIDECREIPGV 1776
Query: 613 CANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMC 672
C N +C N+ G + C CP G +N ++ V E+ + CQNG V C
Sbjct: 1777 CENG-VCINMVGSFRCECPVG------------FFYNDKLLVCED----IDECQNGPV-C 1818
Query: 673 RRMVCDCENPTVDLFCCPECDP--RLSS--QCLHQNGETLYNSGDTWVQNCQQCR--CLQ 726
+R +C N C +C P R +S QC +N CQ+ C
Sbjct: 1819 QRN-AECINTAGSYRC--DCKPGYRFTSTGQCNDRN-------------ECQEIPNICSH 1862
Query: 727 GEVDCWPLPCPDVECEFSIL-----PENECCPRCV-TDPCQADTIRNDITKTCLDEMNVV 780
G+ C D F L N+ C+ + C+ D N + + N
Sbjct: 1863 GQ-------CIDTVGSFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFN-C 1914
Query: 781 RFTGSSWIKHGTEC---TLCQCKNGHIC 805
R + H +C C NG++C
Sbjct: 1915 RCNHGFILSHNNDCIDVDECASGNGNLC 1942
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/124 (31%), Positives = 51/124 (41%), Gaps = 20/124 (16%)
Query: 447 GRHYCRENTMCVNTPGSFMCICKTGYI-RIDDYSCTEHDECITNQHNCDENALCFNTVGG 505
GR + MC P C+ G+I I +C + DEC C + C NTVG
Sbjct: 214 GRAWGHPCEMCPAQPHP----CRRGFIPNIRTGACQDVDECQAIPGLC-QGGNCINTVGS 268
Query: 506 HNCVCKPGYTGNGTTCKAFCKD--------GCRNGGAC---IAANVCACPQGF-TGPSCE 553
C C G+ N + K C+D G GG C +++ C CP GF T P
Sbjct: 269 FECKCPAGHKLNEVSQK--CEDIDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGT 326
Query: 554 TDID 557
ID
Sbjct: 327 RCID 330
>gi|56237021 fibrillin 3 precursor [Homo sapiens]
Length = 2809
Score = 156 bits (395), Expect = 6e-38
Identities = 112/366 (30%), Positives = 159/366 (43%), Gaps = 37/366 (10%)
Query: 291 CKNCTCLN--GTIQCET-----LICPNPDCPLKSALAYVDGKCCK-ECKSICQFQGRTYF 342
C+ TC N G+ +C+ L C + DG C +C ++ +
Sbjct: 1082 CRGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQCVNVIGAFQCSCH 1141
Query: 343 EGERNTVYSSSGVCVLYECKDQT----MKLVESSGCPALDCPESHQITLSHSCCKVCKGY 398
G ++T G + EC+ Q + + + G C + + + + C
Sbjct: 1142 AGFQSTP-DRQGCVDINECRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDG---RACADV 1197
Query: 399 DFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCV 458
D C E + C N+ C C DGF A D C D+DEC H C C
Sbjct: 1198 DECEENPRVCDQGHCTNMPGGHRCLCYDGFMAT-PDMRTCVDVDECDLNPHICLHGD-CE 1255
Query: 459 NTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGN 517
NT GSF+C C+ GY +R C++ DEC HNCD +A C N G +C C PG+ G+
Sbjct: 1256 NTKGSFVCHCQLGYMVRKGATGCSDVDECEVGGHNCDSHASCLNIPGSFSCRCLPGWVGD 1315
Query: 518 GTTCKAF--C---KDGCRNGGACI---AANVCACPQGFTGPS--CETDIDECSDGFVQCD 567
G C C + C G C+ + C C QGF G CE D DEC++ CD
Sbjct: 1316 GFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFCE-DRDECAENVDLCD 1374
Query: 568 SRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYD 627
+ C+N PG Y CEC G+ + +C+D+DEC G + CA + C NL G +
Sbjct: 1375 N-GQCLNAPGGYRCECEMGFDP----TEDHRACQDVDECAQG-NLCAFGS-CENLPGMFR 1427
Query: 628 CRCPHG 633
C C G
Sbjct: 1428 CICNGG 1433
Score = 144 bits (363), Expect = 3e-34
Identities = 159/541 (29%), Positives = 208/541 (38%), Gaps = 92/541 (17%)
Query: 266 DQCYCERTCT-----MKGTT---YREFESWIDGCKNCTCLN--GTIQCETLICPNPDCPL 315
++C + C M G T E ES+ C N C+N G+ +CE CP
Sbjct: 847 ERCEIDPACARGFARMTGVTCDDVNECESFPGVCPNGRCVNTAGSFRCE--------CP- 897
Query: 316 KSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCP 375
+ + G+ C + + F + E E + C + VE CP
Sbjct: 898 EGLMLDASGRLCVDVRLEPCFL--RWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACP 955
Query: 376 ALDCPESHQIT------LSHSCCKVCKGYDFCSERHNCM------ENSICRNLNDRAVCS 423
PES + L + G F + + C + CRN C+
Sbjct: 956 D---PESLEFASLCPRGLGFASRDFLSGRPFYKDVNECKVFPGLCTHGTCRNTVGSFHCA 1012
Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIR--IDDYSCT 481
C GF AL C DIDEC C + T CVNTPGSF C C GY + +C
Sbjct: 1013 CAGGF-ALDAQERNCTDIDECRISPDLCGQGT-CVNTPGSFECECFPGYESGFMLMKNCM 1070
Query: 482 EHDECITNQHNCDENALCFNTVGGHNCVCKPGY--TGNGTTC----KAFCKDGCRNGGAC 535
+ DEC + C C NT G + C C PG+ T GT C + DG G C
Sbjct: 1071 DVDECARDPLLC-RGGTCTNTDGSYKCQCPPGHELTAKGTACEDIDECSLSDGLCPHGQC 1129
Query: 536 ---IAANVCACPQGFTG----PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYH 588
I A C+C GF C DI+EC CD +CIN G Y C C GY
Sbjct: 1130 VNVIGAFQCSCHAGFQSTPDRQGC-VDINECRVQNGGCD--VHCINTEGSYRCSCGQGY- 1185
Query: 589 DNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGD---CIHDGK 645
P G +C D+DEC C + C N+ GG+ C C G T D C+ +
Sbjct: 1186 ---SLMPDGRACADVDECEENPRVC-DQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDE 1241
Query: 646 VKHNGQIWV---LENDRCS-VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCL 701
N I + EN + S VC CQ G+ M R+ C + CD S CL
Sbjct: 1242 CDLNPHICLHGDCENTKGSFVCHCQLGY-MVRKGATGCSDVDECEVGGHNCDSHAS--CL 1298
Query: 702 HQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDV-ECEFSILPENECCPR--CVTD 758
+ G CRCL G V C D+ EC + E+ C PR C+
Sbjct: 1299 NIPGSF-------------SCRCLPGWVGD-GFECHDLDEC---VSQEHRCSPRGDCLNV 1341
Query: 759 P 759
P
Sbjct: 1342 P 1342
Score = 134 bits (337), Expect = 3e-31
Identities = 101/339 (29%), Positives = 143/339 (42%), Gaps = 56/339 (16%)
Query: 313 CPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCV----LYECKDQTMKL 368
CPL AY K C +GR E + G C+ + C Q
Sbjct: 2339 CPLPGTSAY--RKLCPHGSGYTA-EGRDVDECRMLAHLCAHGECINSLGSFRCHCQAGYT 2395
Query: 369 VESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGF 428
+++ LD E C +V K F +C+N +CSC G+
Sbjct: 2396 PDATATTCLDMDE---------CSQVPKPCTF-----------LCKNTKGSFLCSCPRGY 2435
Query: 429 RALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECIT 488
L ED C+D+DEC +H C+ +CVNT G+F C C G+ + +C ++DEC
Sbjct: 2436 -LLEEDGRTCKDLDECTSRQHNCQ--FLCVNTVGAFTCRCPPGFTQ-HHQACFDNDECSA 2491
Query: 489 NQHNCDENALCFNTVGGHNCVCKPGYT--GNGTTCKAF--------CKDGCRNGGACIAA 538
C + C NT G C C G+T +G C+ C+ GC+N +
Sbjct: 2492 QPGPCGAHGHCHNTPGSFRCECHQGFTLVSSGHGCEDVNECDGPHRCQHGCQNQ---LGG 2548
Query: 539 NVCACPQGFTGPS----CETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFS 594
C+CPQGFT S C D +EC+ C S A+C N G + C C G+ F
Sbjct: 2549 YRCSCPQGFTQHSQWAQC-VDENECALSPPTCGS-ASCRNTLGGFRCVCPSGFD----FD 2602
Query: 595 PSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
+ C+++DEC R C+ C N GG+ C CP G
Sbjct: 2603 QALGGCQEVDECAGRRGPCSYS--CANTPGGFLCGCPQG 2639
Score = 130 bits (326), Expect = 6e-30
Identities = 102/372 (27%), Positives = 140/372 (37%), Gaps = 84/372 (22%)
Query: 371 SSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRA 430
+ G CP H++T + C+ D CS + C N+ CSC GF++
Sbjct: 1090 TDGSYKCQCPPGHELTAKGTACE---DIDECSLSDGLCPHGQCVNVIGAFQCSCHAGFQS 1146
Query: 431 LREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITN 489
D C DI+EC C + C+NT GS+ C C GY + D +C + DEC N
Sbjct: 1147 T-PDRQGCVDINECRVQNGGC--DVHCINTEGSYRCSCGQGYSLMPDGRACADVDECEEN 1203
Query: 490 QHNCDENALCFNTVGGHNCVCKPGY--TGNGTTCKAFCKDGCRNGGACIAANVCACPQGF 547
CD+ C N GGH C+C G+ T + TC
Sbjct: 1204 PRVCDQGH-CTNMPGGHRCLCYDGFMATPDMRTC-------------------------- 1236
Query: 548 TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECG 607
D+DEC C +C N G + C C+ GY M C D+DEC
Sbjct: 1237 ------VDVDECDLNPHIC-LHGDCENTKGSFVCHCQLGY----MVRKGATGCSDVDECE 1285
Query: 608 TGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSV----- 662
G H+C + C N+ G + CRC G + DG H+ V + RCS
Sbjct: 1286 VGGHNCDSHASCLNIPGSFSCRCLPG------WVGDGFECHDLDECVSQEHRCSPRGDCL 1339
Query: 663 -------CSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTW 715
C+C+ GF D F C + D + L NG+ L G
Sbjct: 1340 NVPGSYRCTCRQGF-------------AGDGFFCEDRDECAENVDLCDNGQCLNAPGG-- 1384
Query: 716 VQNCQQCRCLQG 727
+C C G
Sbjct: 1385 ----YRCECEMG 1392
Score = 122 bits (307), Expect = 1e-27
Identities = 84/287 (29%), Positives = 117/287 (40%), Gaps = 21/287 (7%)
Query: 399 DFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCV 458
D C E N IC N C C GF CED+DEC C++N C+
Sbjct: 1723 DECGEIPAICANGICINQIGSFRCECPAGFN-YNSILLACEDVDECGSRESPCQQNADCI 1781
Query: 459 NTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNG 518
N PGS+ C C GY +C +EC + C C +T G + C+C G+ +
Sbjct: 1782 NIPGSYRCKCTRGYKLSPGGACVGRNECREIPNVCSHGD-CMDTEGSYMCLCHRGFQASA 1840
Query: 519 TTCKAFCKDGCR----NGGAC---IAANVCACPQGF--TGPSCETDIDECSDGFVQCDSR 569
D C G C I + C C GF T D DEC+ Q
Sbjct: 1841 DQTLCMDIDECDRQPCGNGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRF 1900
Query: 570 ANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR 629
+C+N G +HC C+DG+ + G++C D +EC + +C T C NL+G + C
Sbjct: 1901 GHCLNTAGSFHCLCQDGFE----LTADGKNCVDTNECLSLAGTCLPGT-CQNLEGSFRCI 1955
Query: 630 CPHGKNCTGD-CIHDGKVKHNGQIWVL----ENDRCSVCSCQNGFVM 671
CP G D CI + + + + C C GFV+
Sbjct: 1956 CPPGFQVQSDHCIDIDECSEEPNLCLFGTCTNSPGSFQCLCPPGFVL 2002
Score = 119 bits (299), Expect = 9e-27
Identities = 123/513 (23%), Positives = 185/513 (36%), Gaps = 108/513 (21%)
Query: 343 EGERNTVYSSSGVCV----LYECKDQTMKLVESSGCPALDCPESHQITLSHSC------- 391
E N ++GVCV + C+ ++ +G ++C ++ + ++ H C
Sbjct: 2087 ECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTG---INCVDTDECSVGHPCGQGTCTN 2143
Query: 392 ------CKVCKGYD-----FCSERHNCMENSI-----CRNLNDRAVCSCRDGFRALREDN 435
C G++ C + C N + C N +C+C G+ LRED
Sbjct: 2144 VIGGFECACADGFEPGLMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGY-TLREDG 2202
Query: 436 AYCEDIDECAEGRHYCRENTM-CVNTPGSFMCICKTGYIRI--DDYSCTEHDECITNQHN 492
A C D+DECA+G+ C M C N G+F C+C G + CT+ +EC
Sbjct: 2203 AMCRDVDECADGQQDCHARGMECKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDL 2262
Query: 493 CDENALCFNTVGGHNCVCKPGYTGNGT---------------TCKAFCKDGCRNGGACIA 537
C N C NT G C C G+ + T + C+ + A
Sbjct: 2263 C-VNGRCVNTAGSFRCDCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTR 2321
Query: 538 ANVCACPQGFTGPSCE------------------------TDIDECSDGFVQCDSRANCI 573
A C GP CE D+DEC C + CI
Sbjct: 2322 AECCCGGGRGWGPRCELCPLPGTSAYRKLCPHGSGYTAEGRDVDECRMLAHLC-AHGECI 2380
Query: 574 NLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPH- 632
N G + C C+ GY + + +C D+DEC C +C N G + C CP
Sbjct: 2381 NSLGSFRCHCQAGYTPDA----TATTCLDMDECSQVPKPCT--FLCKNTKGSFLCSCPRG 2434
Query: 633 ------GKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDL 686
G+ C D +HN Q + C C GF + D + +
Sbjct: 2435 YLLEEDGRTCK-DLDECTSRQHNCQFLCVNTVGAFTCRCPPGFTQHHQACFDNDECSAQP 2493
Query: 687 FCC---PECDPRLSS-QCLHQNGETLYNSGDTWVQNCQQC----RC---LQGEVDCWPLP 735
C C S +C G TL +SG ++ +C RC Q ++ +
Sbjct: 2494 GPCGAHGHCHNTPGSFRCECHQGFTLVSSGH-GCEDVNECDGPHRCQHGCQNQLGGYRCS 2552
Query: 736 CPDVECEFS----ILPENECC---PRCVTDPCQ 761
CP + S + ENEC P C + C+
Sbjct: 2553 CPQGFTQHSQWAQCVDENECALSPPTCGSASCR 2585
Score = 112 bits (279), Expect = 2e-24
Identities = 126/485 (25%), Positives = 177/485 (36%), Gaps = 109/485 (22%)
Query: 379 CPESHQITLSHSCCKVCK-GYDFCSERHNCMENS------------ICRNLNDRAVCSCR 425
C H + + S +C+ G++ ++ NC++ + C+NL C C
Sbjct: 1898 CRFGHCLNTAGSFHCLCQDGFELTADGKNCVDTNECLSLAGTCLPGTCQNLEGSFRCICP 1957
Query: 426 DGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDD-YSC--TE 482
GF+ + +C DIDEC+E + C T C N+PGSF C+C G++ D+ + C T
Sbjct: 1958 PGFQVQSD---HCIDIDECSEEPNLCLFGT-CTNSPGSFQCLCPPGFVLSDNGHRCFDTR 2013
Query: 483 HDECITN-QHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDG------------- 528
C T + FNT C K G G C+ ++G
Sbjct: 2014 QSFCFTRFEAGKCSVPKAFNTTKTRCCCSKRPGEGWGDPCELCPQEGSAAFQELCPFGHG 2073
Query: 529 ---------------CRNGGAC---IAANV-----CACPQG----FTGPSCETDIDECSD 561
N G C + N C CP G FTG +C D DECS
Sbjct: 2074 AVPGPDDSREDVNECAENPGVCTNGVCVNTDGSFRCECPFGYSLDFTGINC-VDTDECSV 2132
Query: 562 GFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFN 621
G C + C N+ G + C C DG+ M +CEDIDEC CA C N
Sbjct: 2133 GH-PC-GQGTCTNVIGGFECACADGFEPGLMM-----TCEDIDECSLNPLLCA--FRCHN 2183
Query: 622 LDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCEN 681
+G Y C CP G DG + + V C +G C +C+N
Sbjct: 2184 TEGSYLCTCPAGYTLR----EDGAMCRD------------VDECADGQQDCHARGMECKN 2227
Query: 682 PTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQN--CQQCRCLQ--GEVDCWPLPCP 737
+ F C C P + + L +GE + + Q C RC+ G C
Sbjct: 2228 -LIGTFAC-VCPPGM--RPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRC------ 2277
Query: 738 DVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFT-----GSSWIKHGT 792
D + F P C PC A+ ++ V R G W G
Sbjct: 2278 DCDEGFQPSPTLTECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGW---GP 2334
Query: 793 ECTLC 797
C LC
Sbjct: 2335 RCELC 2339
Score = 109 bits (273), Expect = 9e-24
Identities = 119/467 (25%), Positives = 169/467 (36%), Gaps = 107/467 (22%)
Query: 288 IDGCKNCTCLNGTI----QCETL---ICPNPDCPLKSALAYVDGKCCKECKSICQFQGRT 340
I G +C CL G + +C L + C + V G C+ F G
Sbjct: 1300 IPGSFSCRCLPGWVGDGFECHDLDECVSQEHRCSPRGDCLNVPGSYRCTCRQ--GFAGDG 1357
Query: 341 YFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDF 400
+F +R+ + +C +C + + G +C T H + C+ D
Sbjct: 1358 FFCEDRDECAENVDLCDNGQC-------LNAPGGYRCECEMGFDPTEDH---RACQDVDE 1407
Query: 401 CSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNT 460
C++ + C S C NL C C G+ L C DI+ECA+ + N +C+NT
Sbjct: 1408 CAQGNLCAFGS-CENLPGMFRCICNGGYE-LDRGGGNCTDINECADPVNCI--NGVCINT 1463
Query: 461 PGSFMCICKTGY-IRIDDYSC--TEHDECITNQHNCDENAL-CFNTVG----GHNCVCKP 512
PGS++C C + + C T C H+ ++ + C +G +C C
Sbjct: 1464 PGSYLCSCPQDFELNPSGVGCVDTRAGNCFLETHDRGDSGISCSAEIGVGVTRASCCCSL 1523
Query: 513 GYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCET----DIDECSDGFVQCDS 568
G G C+ C +C +GF P+ T DIDEC + C
Sbjct: 1524 GRAW-GNPCEL-----CPMANTTEYRTLCPGGEGFQ-PNRITVILEDIDECQELPGLCQG 1576
Query: 569 RANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
+C+N G + CEC GYH S CEDIDEC T C T C+N G Y C
Sbjct: 1577 -GDCVNTFGSFQCECPPGYH----LSEHTRICEDIDECSTHSGICGPGT-CYNTLGNYTC 1630
Query: 629 RCP-------HGKNCTGDCIHDGKVKHNGQIWVLENDRCSVC------SCQNGFVMCRRM 675
CP G NC + R SVC +CQN
Sbjct: 1631 VCPAEYLQVNGGNNCM-------------------DMRKSVCFRHYNGTCQNELAF---- 1667
Query: 676 VCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQC 722
N T + CC YN G W + C+ C
Sbjct: 1668 -----NVTRKMCCCS------------------YNIGQAWNRPCEAC 1691
Score = 103 bits (258), Expect = 5e-22
Identities = 126/480 (26%), Positives = 175/480 (36%), Gaps = 129/480 (26%)
Query: 352 SSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENS 411
S G+C L C V + G C +++ K C ++ C+ C+ N
Sbjct: 496 SGGLCHLGRC-------VNTEGSFQCVCNAGFELSPDG---KNCVDHNECATSTMCV-NG 544
Query: 412 ICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTG 471
+C N + C C+ GF L YC DIDEC + C N C NT GSF C C G
Sbjct: 545 VCLNEDGSFSCLCKPGF-LLAPGGHYCMDIDEC-QTPGIC-VNGHCTNTEGSFRCQCLGG 601
Query: 472 -------------YIRIDDYSCTEHDEC-------ITNQHNCDENALCFNTVGGHNCVCK 511
++R Y E C +T C C N G C+
Sbjct: 602 LAVGTDGRVCVDTHVRSTCYGAIEKGSCARPFPGTVTKSECC-----CANPDHGFGEPCQ 656
Query: 512 PGYTGNGTTCKAFCKDG-------------------CRNGGACIAANV-----CACPQGF 547
+ +A C G C NG + N+ C C G+
Sbjct: 657 LCPAKDSAEFQALCSSGLGITTDGRDINECALDPEVCANG---VCENLRGSYRCVCNLGY 713
Query: 548 ----TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDI 603
+G C TD+DEC+ + CD+ C N PG Y C C G+H F E C+D+
Sbjct: 714 EAGASGKDC-TDVDECALNSLLCDN-GWCQNSPGSYSCSCPPGFH----FWQDTEICKDV 767
Query: 604 DECGTGRHSCANDTICFNLDGGYDCRC-------PHGKNC----TGDC---IHDGKVKHN 649
DEC + C + +C NL G Y C+C P G C G C I + + + N
Sbjct: 768 DECLSS--PCVSG-VCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVN 824
Query: 650 --------------GQIWVLENDRCSV-CSCQNGFVMCRRMVCDCENPTVDLFCCPECDP 694
G W +RC + +C GF + CD N EC+
Sbjct: 825 LQGASLRSECCATLGAAWGSPCERCEIDPACARGFARMTGVTCDDVN---------ECE- 874
Query: 695 RLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQG-EVDCWPLPCPDVECE--FSILPENEC 751
S + NG + +G +C C +G +D C DV E F E+EC
Sbjct: 875 --SFPGVCPNGRCVNTAGSF------RCECPEGLMLDASGRLCVDVRLEPCFLRWDEDEC 926
Score = 103 bits (258), Expect = 5e-22
Identities = 82/282 (29%), Positives = 108/282 (38%), Gaps = 41/282 (14%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C G + C E N + C + +C C GF+A D C DIDEC R C
Sbjct: 1803 CVGRNECREIPNVCSHGDCMDTEGSYMCLCHRGFQA-SADQTLCMDIDEC--DRQPCGNG 1859
Query: 455 TMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY 514
T C N GS+ C+C G++ + C + DEC T C NT G +C+C+ G+
Sbjct: 1860 T-CKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVCRFGHCLNTAGSFHCLCQDGF 1918
Query: 515 --TGNGTTCKAFCKDGCRNGGACIAANV--------CACPQGFTGPSCE-TDIDECSDGF 563
T +G C + G C+ C CP GF S DIDECS+
Sbjct: 1919 ELTADGKNC-VDTNECLSLAGTCLPGTCQNLEGSFRCICPPGFQVQSDHCIDIDECSEEP 1977
Query: 564 VQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLD 623
C C N PG + C C G+ + S +G C D + CF
Sbjct: 1978 NLC-LFGTCTNSPGSFQCLCPPGF----VLSDNGHRCFD-----------TRQSFCFTRF 2021
Query: 624 GGYDCRCPHGKNCTGD--CIHDGKVKHNGQIWVLENDRCSVC 663
C P N T C K G+ W D C +C
Sbjct: 2022 EAGKCSVPKAFNTTKTRCCCS----KRPGEGW---GDPCELC 2056
Score = 95.9 bits (237), Expect = 1e-19
Identities = 89/312 (28%), Positives = 122/312 (39%), Gaps = 68/312 (21%)
Query: 374 CPALDCPESHQITLSHSCCKVCKGYDF--CSERHNCMENSICRNLNDRAVCSCRDGFRAL 431
CPA D E Q S G D C+ N +C NL C C G+ A
Sbjct: 658 CPAKDSAE-FQALCSSGLGITTDGRDINECALDPEVCANGVCENLRGSYRCVCNLGYEA- 715
Query: 432 REDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQ 490
C D+DECA C +N C N+PGS+ C C G+ D C + DEC+++
Sbjct: 716 GASGKDCTDVDECALNSLLC-DNGWCQNSPGSYSCSCPPGFHFWQDTEICKDVDECLSSP 774
Query: 491 HNCDENALCFNTVGGHNCVCKPG--YTGNGTTCKAFCKDGC-----------RNGGACIA 537
C + +C N G + C C PG +GT C K C GA +
Sbjct: 775 --C-VSGVCRNLAGSYTCKCGPGSRLDPSGTFCLDSTKGTCWLKIQESRCEVNLQGASLR 831
Query: 538 ANVC------------------ACPQGF---TGPSCETDIDECSDGFVQCDSRANCINLP 576
+ C AC +GF TG +C+ D++EC + F C+N
Sbjct: 832 SECCATLGAAWGSPCERCEIDPACARGFARMTGVTCD-DVNEC-ESFPGVCPNGRCVNTA 889
Query: 577 GWYHCECRDGYHDNGMFSPSGESCEDI-----------DECGT---GRHSCANDTICFNL 622
G + CEC +G M SG C D+ DECG G++ D C ++
Sbjct: 890 GSFRCECPEGL----MLDASGRLCVDVRLEPCFLRWDEDECGVTLPGKYRM--DVCCCSI 943
Query: 623 DG--GYDCR-CP 631
G +C CP
Sbjct: 944 GAVWGVECEACP 955
Score = 87.8 bits (216), Expect = 4e-17
Identities = 65/209 (31%), Positives = 91/209 (43%), Gaps = 28/209 (13%)
Query: 439 EDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQ-HNCDENA 497
+ ID C + C N C+ TP S+ C C GY + C + DEC ++ H+ D
Sbjct: 407 QTIDICRHFTNLCL-NGRCLPTPSSYRCECNVGYTQDVRGECIDVDECTSSPCHHGD--- 462
Query: 498 LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGC-RNGGACIAANV--------CACPQGF- 547
C N G ++C C PG+ T D C +GG C C C GF
Sbjct: 463 -CVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGRCVNTEGSFQCVCNAGFE 521
Query: 548 ---TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDID 604
G +C D +EC+ C + C+N G + C C+ G+ + +P G C DID
Sbjct: 522 LSPDGKNC-VDHNECATS-TMCVNGV-CLNEDGSFSCLCKPGF----LLAPGGHYCMDID 574
Query: 605 ECGTGRHSCANDTICFNLDGGYDCRCPHG 633
EC T C N C N +G + C+C G
Sbjct: 575 ECQT-PGICVNGH-CTNTEGSFRCQCLGG 601
Score = 87.4 bits (215), Expect = 5e-17
Identities = 74/264 (28%), Positives = 103/264 (39%), Gaps = 37/264 (14%)
Query: 385 ITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDEC 444
+T + CC + + + + C + R +C +GF+ R EDIDEC
Sbjct: 1514 VTRASCCCSLGRAWG-----NPCELCPMANTTEYRTLCPGGEGFQPNRI-TVILEDIDEC 1567
Query: 445 AEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS--CTEHDECITNQHNCDENALCFNT 502
E C+ CVNT GSF C C GY + +++ C + DEC T+ C C+NT
Sbjct: 1568 QELPGLCQGGD-CVNTFGSFQCECPPGY-HLSEHTRICEDIDECSTHSGICGPGT-CYNT 1624
Query: 503 VGGHNCVCKPGY--TGNGTTCKAFCKDGC--RNGGAC-------IAANVCACPQGFTGPS 551
+G + CVC Y G C K C G C + +C C G +
Sbjct: 1625 LGNYTCVCPAEYLQVNGGNNCMDMRKSVCFRHYNGTCQNELAFNVTRKMCCCSYNI-GQA 1683
Query: 552 CETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRH 611
+ C + D + C N + + G DIDECG
Sbjct: 1684 WNRPCEACPTP-ISPDYQILCGNQAPGFLTDIHTG------------KPLDIDECGEIPA 1730
Query: 612 SCANDTICFNLDGGYDCRCPHGKN 635
CAN IC N G + C CP G N
Sbjct: 1731 ICANG-ICINQIGSFRCECPAGFN 1753
Score = 82.8 bits (203), Expect = 1e-15
Identities = 75/290 (25%), Positives = 103/290 (35%), Gaps = 72/290 (24%)
Query: 444 CAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTV 503
C EG +C + +C G+ C ++ C + + T
Sbjct: 90 CGEG--FCSQPNLCTCADGTLAPSCG-----------------VSRGSGCSVSCMNGGTC 130
Query: 504 GGHNCVCKPGYTGNGTTC-KAFCKDGCRNGGACIAANVCACPQGFTGPSCETDI------ 556
G +C+C+ GYTG T C + C GC NGG CI N CAC GF GP CE D
Sbjct: 131 RGASCLCQKGYTG--TVCGQPICDRGCHNGGRCIGPNRCACVYGFMGPQCERDYRTGPCF 188
Query: 557 -----DECSDGF--VQCDSRANCINLP-GW-YHCE--------CRDGYHDNGMFSPSGES 599
+ C + C C + W CE CR G+ N +
Sbjct: 189 GQVGPEGCQHQLTGLVCTKALCCATVGRAWGLPCELCPAQPHPCRRGFIPNIHTG----A 244
Query: 600 CEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDR 659
C+D+DEC C + C N+ G + CRCP G + + VL R
Sbjct: 245 CQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGHRLSDSSAACEDYRAGACFSVLFGGR 303
Query: 660 CS----------VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQ 699
C+ C C G C P +L C PR S++
Sbjct: 304 CAGDLAGHYTRRQCCCDRG-------RCWAAGPVPEL-----CPPRGSNE 341
Score = 59.7 bits (143), Expect = 1e-08
Identities = 84/339 (24%), Positives = 115/339 (33%), Gaps = 76/339 (22%)
Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEH 483
CR GF A C+D+DEC C+ + CVN GSF C C G+ R+ D S
Sbjct: 232 CRRGFIPNIHTGA-CQDVDECQAVPGLCQGGS-CVNMVGSFHCRCPVGH-RLSDSSAACE 288
Query: 484 DECITNQHNCDENALCFNTVGGH----NCVCK---------------------------- 511
D + C + GH C C
Sbjct: 289 DYRAGACFSVLFGGRCAGDLAGHYTRRQCCCDRGRCWAAGPVPELCPPRGSNEFQQLCAQ 348
Query: 512 -----PGYTGNGTTCKAFCKDGCR--------NGGACIAANVCACPQGFTGPSCET---D 555
PG+ G F +G N A + + G + T
Sbjct: 349 RLPLLPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQT 408
Query: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 615
ID C F C+ P Y CEC GY + GE C D+DEC + S +
Sbjct: 409 IDICRH-FTNLCLNGRCLPTPSSYRCECNVGYTQD----VRGE-CIDVDECTS---SPCH 459
Query: 616 DTICFNLDGGYDCRCPHGKNCT---------GDCIHDGKVKHNGQIWVLENDRCSVCSCQ 666
C N+ G Y CRC G T +CI G + H G+ + + C C
Sbjct: 460 HGDCVNIPGTYHCRCYPGFQATPTRQACVDVDECIVSGGLCHLGR--CVNTEGSFQCVCN 517
Query: 667 NGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNG 705
GF + D +N VD C ++ CL+++G
Sbjct: 518 AGF----ELSPDGKN-CVDHNECATSTMCVNGVCLNEDG 551
Score = 47.4 bits (111), Expect = 5e-05
Identities = 64/258 (24%), Positives = 86/258 (33%), Gaps = 77/258 (29%)
Query: 389 HSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS------CRDGFRALREDNAYCEDID 442
H+ C C G+ R C+ ICR CS C DG A
Sbjct: 65 HAYC--CPGWRTFPGRSQCVV-PICRRACGEGFCSQPNLCTCADGTLA-----------P 110
Query: 443 ECAEGRHY-CRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFN 501
C R C + M T C+C+ GY + Q CD C N
Sbjct: 111 SCGVSRGSGCSVSCMNGGTCRGASCLCQKGYTGT-----------VCGQPICDRG--CHN 157
Query: 502 ---TVGGHNCVCKPGYTG--------NGTTCKAFCKDGCRN---GGACIAANVCA----- 542
+G + C C G+ G G +GC++ G C A CA
Sbjct: 158 GGRCIGPNRCACVYGFMGPQCERDYRTGPCFGQVGPEGCQHQLTGLVCTKALCCATVGRA 217
Query: 543 --------------CPQGFTGPSCET----DIDECSDGFVQCDSRANCINLPGWYHCECR 584
C +GF P+ T D+DEC C +C+N+ G +HC C
Sbjct: 218 WGLPCELCPAQPHPCRRGFI-PNIHTGACQDVDECQAVPGLCQG-GSCVNMVGSFHCRCP 275
Query: 585 DGYHDNGMFSPSGESCED 602
G+ S S +CED
Sbjct: 276 VGHR----LSDSSAACED 289
>gi|51873053 fibulin 2 isoform a precursor [Homo sapiens]
Length = 1231
Score = 155 bits (393), Expect = 1e-37
Identities = 123/420 (29%), Positives = 164/420 (39%), Gaps = 60/420 (14%)
Query: 401 CSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNT 460
C + C + +C + A+CSC G+ A+ D CED DEC G H C CVNT
Sbjct: 683 CKDNGPCKQ--VCSTVGGSAICSCFPGY-AIMADGVSCEDQDECLMGAHDCSRRQFCVNT 739
Query: 461 PGSFMCI-----CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC----VCK 511
GSF C+ C GYI C + +EC+T+ H C C NT+G +C C+
Sbjct: 740 LGSFYCVNHTVLCADGYILNAHRKCVDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCE 799
Query: 512 PGYTGNGTTCKAF---------CKDG--CRNG-GACIAANVCACPQGFTGP---SCETDI 556
PGY C+ C+ G C+N G+ C GF +C DI
Sbjct: 800 PGYALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNC-VDI 858
Query: 557 DECSDGFVQCDSRANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRH 611
+EC+ C +CIN G Y C+ C GYH S G C D++EC TG H
Sbjct: 859 NECTSLSEPCRPGFSCINTVGSYTCQRNPLICARGYHA----SDDGTKCVDVNECETGVH 914
Query: 612 SCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS---------- 661
C +C NL G Y C C G D G + N + W C
Sbjct: 915 RCGEGQVCHNLPGSYRCDCKAG--FQRDAFGRGCIDVN-ECWASPGRLCQHTCENTLGSY 971
Query: 662 VCSCQNGFVMCR-RMVCDCENPTVDLFCCPECDPRLSS-QCLHQNGETLYNSGDTW--VQ 717
CSC +GF++ C+ N C EC S QC + G L G T +
Sbjct: 972 RCSCASGFLLAADGKRCEDVNECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDID 1031
Query: 718 NCQQCRCLQGEVDCWPLP----CPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTC 773
C Q + C +P C E +++ C D C T +TC
Sbjct: 1032 ECAQGAGILCTFRCLNVPGSYQCACPEQGYTMTANGRSCKD--VDECALGTHNCSEAETC 1089
Score = 136 bits (343), Expect = 7e-32
Identities = 93/303 (30%), Positives = 134/303 (44%), Gaps = 76/303 (25%)
Query: 388 SHSC-----CKVCKGYDFCSERHNCMENSI------CRNLNDRAVCS--CRDGFRALR-- 432
+H+C C+ KG +C R CM+ + C ++N+ S CR GF +
Sbjct: 819 THTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTV 878
Query: 433 -------------------EDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYI 473
+D C D++EC G H C E +C N PGS+ C CK G+
Sbjct: 879 GSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQ 938
Query: 474 RIDDY--SCTEHDECITN-----QHNCDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF 524
R D + C + +EC + QH C+ NT+G + C C G+ +G C+
Sbjct: 939 R-DAFGRGCIDVNECWASPGRLCQHTCE------NTLGSYRCSCASGFLLAADGKRCEDV 991
Query: 525 -------CKDGCRNGGACIAANVCACPQGF----TGPSCETDIDECSDGF-VQCDSRANC 572
C C N + C C QG+ G +C TDIDEC+ G + C R C
Sbjct: 992 NECEAQRCSQECAN---IYGSYQCYCRQGYQLAEDGHTC-TDIDECAQGAGILCTFR--C 1045
Query: 573 INLPGWYHCEC-RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC--- 628
+N+PG Y C C GY + +G SC+D+DEC G H+C+ C N+ G + C
Sbjct: 1046 LNVPGSYQCACPEQGY----TMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRF 1101
Query: 629 RCP 631
CP
Sbjct: 1102 ECP 1104
Score = 79.7 bits (195), Expect = 1e-14
Identities = 110/416 (26%), Positives = 160/416 (38%), Gaps = 72/416 (17%)
Query: 439 EDIDECAE-GRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENA 497
+D DEC C+ +C+NT GS+ C C G+ DD + E A
Sbjct: 603 DDQDECLLLPGELCQH--LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPA 660
Query: 498 LC--FNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFT----GPS 551
L F+ V N + P N CK C G + +C+C G+ G S
Sbjct: 661 LKSEFSQVAS-NTIPLPLPQPNTCKDNGPCKQVCSTVG---GSAICSCFPGYAIMADGVS 716
Query: 552 CETDIDECSDGFVQCDSRANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDEC 606
CE D DEC G C R C+N G ++C C DGY N + C DI+EC
Sbjct: 717 CE-DQDECLMGAHDCSRRQFCVNTLGSFYCVNHTVLCADGYILN-----AHRKCVDINEC 770
Query: 607 GTGRHSCANDTICFNLDGGYDCRCPHGKNC-TGDCIHDGKVKHNGQIWVLENDRCSV--C 663
T H+C+ C N G + C C G + DG+ + + D C++
Sbjct: 771 VTDLHTCSRGEHCVNTLGSF--HCYKALTCEPGYALKDGECE--------DVDECAMGTH 820
Query: 664 SCQNGFVMCR----------RMVC------DCENPTVDLFCCPECDPRLSSQCLHQNGET 707
+CQ GF +C+ R C D E VD+ C LS C + G +
Sbjct: 821 TCQPGF-LCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTS----LSEPC--RPGFS 873
Query: 708 LYNSGDTWVQNCQQCRCLQG-EVDCWPLPCPDV-ECEFSI--LPENECC---PRCVTDPC 760
N+ ++ C +G C DV ECE + E + C P C
Sbjct: 874 CINTVGSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDC 933
Query: 761 QADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTL----CQCKNGHICCSVDPQC 812
+A R+ + C+D +N + +H E TL C C +G + + +C
Sbjct: 934 KAGFQRDAFGRGCID-VNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRC 988
Score = 60.1 bits (144), Expect = 8e-09
Identities = 41/156 (26%), Positives = 63/156 (40%), Gaps = 16/156 (10%)
Query: 356 CVLYECKDQTMKLVESSGCPALDCPESHQITLS-HSCCKVCKGYDFCSERHNCMENSICR 414
C C + + S C C + +Q+ H+C + D C++ + C
Sbjct: 994 CEAQRCSQECANIYGSYQCY---CRQGYQLAEDGHTCTDI----DECAQGAGILCTFRCL 1046
Query: 415 NLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCI---CKTG 471
N+ C+C + + + C+D+DECA G H C E C N GSF C+ C
Sbjct: 1047 NVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPN 1106
Query: 472 YIRIDDYSC---TEHD--ECITNQHNCDENALCFNT 502
Y+++ C T HD EC + L F T
Sbjct: 1107 YVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQT 1142
Score = 34.7 bits (78), Expect = 0.37
Identities = 30/110 (27%), Positives = 47/110 (42%), Gaps = 19/110 (17%)
Query: 639 DCIHDGKVKHN---GQIWVLENDRCSVCSCQNG-------FVMCRRMVCDCENPTVDLFC 688
DC+ G V+ GQ + ++ CSC G F++C + +C V
Sbjct: 72 DCLQGGFVRGRVPAGQSYFVDFGSTE-CSCPPGGGKISCQFMLCPELPPNCIEAVVVADS 130
Query: 689 CPECDPRLSSQCLHQNGETLYNSGDT-WVQNCQQCRC--LQGEVDCWPLP 735
CP+C C+H + Y +G T + C+ C C GE+ C+ LP
Sbjct: 131 CPQCG---QVGCVHAGHK--YAAGHTVHLPPCRACHCPDAGGELICYQLP 175
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 154 bits (390), Expect = 2e-37
Identities = 147/529 (27%), Positives = 209/529 (39%), Gaps = 100/529 (18%)
Query: 288 IDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGER- 346
+D C CLNG + + N CP + G+ C E CQ Q G
Sbjct: 237 VDDCPGHRCLNGGTCVDGVNTYNCQCPPEWT-----GQFCTEDVDECQLQPNACHNGGTC 291
Query: 347 -NTVYSSSGVCVLYECKDQTMKLVESSGCPALDC---PESHQITLSHSCC-------KVC 395
NT+ S VCV + + ++ C C H S C +C
Sbjct: 292 FNTLGGHSCVCVNGWTGESCSQNIDD--CATAVCFHGATCHDRVASFYCACPMGKTGLLC 349
Query: 396 KGYDFCSERHNCMENSIC--RNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRE 453
D C + C E++IC +N RA+C+C GF A +D+DEC+ G + C
Sbjct: 350 HLDDACVS-NPCHEDAICDTNPVNGRAICTCPPGFTG----GACDQDVDECSIGANPCEH 404
Query: 454 NTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPG 513
CVNT GSF+C C GY T+ +EC++ C A C + +G C+C G
Sbjct: 405 LGRCVNTQGSFLCQCGRGY--TGPRCETDVNECLSGP--CRNQATCLDRIGQFTCICMAG 460
Query: 514 YTGNGTTCKA---FCKDG-CRNGGAC---IAANVCACPQGFTGPSCETDIDECSDGFVQC 566
+T GT C+ C+ C NGG C + C CP GF+G +C+ D+DEC+ C
Sbjct: 461 FT--GTYCEVDIDECQSSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECAS--TPC 516
Query: 567 DSRANCINLPGWYHCECRDGYHD---------------------NGMFSPS--------G 597
+ A C++ P Y C C +G+ +G+ S S G
Sbjct: 517 RNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTG 576
Query: 598 ESCE-DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLE 656
CE +DEC + C + C +L Y CRCP G TG V I
Sbjct: 577 TRCESQVDECRS--QPCRHGGKCLDLVDKYLCRCPSG--TTG-------VNCEVNIDDCA 625
Query: 657 NDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWV 716
++ C+ C++G R C C+ C E + SS C G + V
Sbjct: 626 SNPCTFGVCRDGI---NRYDCVCQPGFTGPLCNVEINECASSPC---------GEGGSCV 673
Query: 717 --QNCQQCRCLQGEVD--CWP--LPCPDVECEFSILPENECCPRCVTDP 759
+N +C C G + C P PC C I + RCV +P
Sbjct: 674 DGENGFRCLCPPGSLPPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEP 722
Score = 139 bits (351), Expect = 8e-33
Identities = 125/464 (26%), Positives = 175/464 (37%), Gaps = 126/464 (27%)
Query: 407 CMENSICRNLNDRAV-CSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSF 464
C CR D C+C GF + CE ++D+C H C CV+ ++
Sbjct: 206 CRNGGTCRQSGDLTYDCACLPGF-----EGQNCEVNVDDCPG--HRCLNGGTCVDGVNTY 258
Query: 465 MCICKTGYIRIDDYSCTEH-DECITNQHNCDENALCFNTVGGHNCVCKPGYTG------- 516
C C + CTE DEC + C CFNT+GGH+CVC G+TG
Sbjct: 259 NCQCPPEWT---GQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNI 315
Query: 517 ---------NGTTC-----KAFC-----KDG--CRNGGACIA----------------AN 539
+G TC +C K G C AC++
Sbjct: 316 DDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRA 375
Query: 540 VCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGES 599
+C CP GFTG +C+ D+DECS G C+ C+N G + C+C GY +G
Sbjct: 376 ICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGY--------TGPR 427
Query: 600 CE-DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLEND 658
CE D++EC +G C N C + G + C C G G ++ D
Sbjct: 428 CETDVNECLSG--PCRNQATCLDRIGQFTCICMAG--------------FTGTYCEVDID 471
Query: 659 RCSVCSCQNGFVMCRRMV----CDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDT 714
C C NG V C+ V C C + C + D S+ C +NG + D
Sbjct: 472 ECQSSPCVNGGV-CKDRVNGFSCTCPSGFSGSTCQLDVDECASTPC--RNGAKCVDQPDG 528
Query: 715 WVQNCQQCRCLQG---------EVDCWPLPCPDVECEFSILPEN-ECCPRCVTDPCQADT 764
+ +CRC +G DC P PC C I + C P C++
Sbjct: 529 Y-----ECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQ- 582
Query: 765 IRNDITKTCLDEMNVVRFTGSSWIKHGTECT------LCQCKNG 802
+DE S +HG +C LC+C +G
Sbjct: 583 ---------VDECR------SQPCRHGGKCLDLVDKYLCRCPSG 611
Score = 114 bits (284), Expect = 5e-25
Identities = 138/561 (24%), Positives = 194/561 (34%), Gaps = 154/561 (27%)
Query: 262 MNRLDQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLI------CPN----- 310
++R+ Q C M G T E ID C++ C+NG + C+ + CP+
Sbjct: 447 LDRIGQFTC---ICMAGFTGTYCEVDIDECQSSPCVNGGV-CKDRVNGFSCTCPSGFSGS 502
Query: 311 ------PDC---PLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYEC 361
+C P ++ VD EC+ F+G +RN S C C
Sbjct: 503 TCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLC---DRNVDDCSPDPCHHGRC 559
Query: 362 KD--QTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSE----------RHNCME 409
D + + G C S C K D + NC
Sbjct: 560 VDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRCPSGTTGVNCEV 619
Query: 410 N-----------SICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMC 457
N +CR+ +R C C+ GF C +I+ECA C E C
Sbjct: 620 NIDDCASNPCTFGVCRDGINRYDCVCQPGF-----TGPLCNVEINECASSP--CGEGGSC 672
Query: 458 VNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCD----ENALCFNTVGGHNCVCKPG 513
V+ F C+C G + C+ H C + +C++ GG CVC+PG
Sbjct: 673 VDGENGFRCLCPPGSL---------PPLCLPPSHPCAHEPCSHGICYDAPGGFRCVCEPG 723
Query: 514 YTG------------------NGTTCKA-------FCKDG----------------CRNG 532
++G G TC + C G C +G
Sbjct: 724 WSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPCTPNPCEHG 783
Query: 533 GACIAA----NVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYH 588
G C +A VC+CPQG+ GP C+ D+DEC+ G C C NL G + C C GY
Sbjct: 784 GRCESAPGQLPVCSCPQGWQGPRCQQDVDECA-GPAPCGPHGICTNLAGSFSCTCHGGY- 841
Query: 589 DNGMFSPSGESC-EDIDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTGD---CI 641
+G SC +DI++C + C N C + G + C C G C D C+
Sbjct: 842 -------TGPSCDQDINDCDP--NPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECL 892
Query: 642 HDG-----------------KVKHNGQIWVLENDRCSVCSCQNGFVM---CRRMVCDCEN 681
+ + G + CS SC NG C C
Sbjct: 893 SNPCGPGTCTDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCRP 952
Query: 682 PTVDLFCCPECDPRLSSQCLH 702
C E DP LS CLH
Sbjct: 953 GYTGAHCQHEADPCLSRPCLH 973
Score = 102 bits (254), Expect = 1e-21
Identities = 100/346 (28%), Positives = 132/346 (38%), Gaps = 75/346 (21%)
Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMC 466
C+ C++ CSC GF R D+DEC C T C + SF C
Sbjct: 858 CLNGGSCQDGVGSFSCSCLPGFAGPR----CARDVDECLSNP--CGPGT-CTDHVASFTC 910
Query: 467 ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKA--F 524
C GY + C E D + +C C + V +C+C+PGYTG +A
Sbjct: 911 TCPPGY---GGFHC-EQDLPDCSPSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPC 966
Query: 525 CKDGCRNGGACIAANV---CACPQGFTGPSCETDIDECSDGFVQCDSR-----ANCINLP 576
C +GG C AA+ C C + FTGP C+T +D CS Q R A C+ P
Sbjct: 967 LSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPP 1026
Query: 577 GWYH--CE-----CRDGYHDNGM----FSPSGESCEDID--------ECGTGRH------ 611
GW C+ CR+ G+ +G C D D E TG H
Sbjct: 1027 GWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVD 1086
Query: 612 -----SCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQ 666
C + C GGY C C G N GD D + D C+ CQ
Sbjct: 1087 PCLAQPCQHGGTCRGYMGGYMCECLPGYN--GDNCED------------DVDECASQPCQ 1132
Query: 667 NG---FVMCRRMVCDCENPTVDLFCCPECD-----PRLSS--QCLH 702
+G + R +C C T+ + C D P L S +CLH
Sbjct: 1133 HGGSCIDLVARYLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLH 1178
Score = 95.1 bits (235), Expect = 2e-19
Identities = 90/348 (25%), Positives = 128/348 (36%), Gaps = 70/348 (20%)
Query: 421 VCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSC 480
VCSC G++ R +D+DECA G C + +C N GSF C C GY SC
Sbjct: 795 VCSCPQGWQGPRCQ----QDVDECA-GPAPCGPHGICTNLAGSFSCTCHGGY---TGPSC 846
Query: 481 TEH-DECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKA-FCKDGCRNGGAC--- 535
+ ++C N C C + VG +C C PG+ G C G C
Sbjct: 847 DQDINDCDPNP--CLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNPCGPGTCTDH 904
Query: 536 IAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSP 595
+A+ C CP G+ G CE D+ +CS C + C++ + C CR GY
Sbjct: 905 VASFTCTCPPGYGGFHCEQDLPDCSPS--SCFNGGTCVDGVNSFSCLCRPGY-------- 954
Query: 596 SGESCE-DIDECGTGRHSCANDTICFNLDGGYDCRCPH---GKNCT-------------- 637
+G C+ + D C + C + +C G+ C C G C
Sbjct: 955 TGAHCQHEADPCLS--RPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNG 1012
Query: 638 GDCIHDGKV-----KHNGQIWVLENDRCSVCSCQNGF---VMCR----------RMVCDC 679
G C+ G +G++ + + C + Q G +C+ C C
Sbjct: 1013 GRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVC 1072
Query: 680 ENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQG 727
C E DP L+ C H Y G C CL G
Sbjct: 1073 PEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGG-------YMCECLPG 1113
Score = 94.7 bits (234), Expect = 3e-19
Identities = 101/417 (24%), Positives = 137/417 (32%), Gaps = 115/417 (27%)
Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCED-IDECAEGRHYCRENTMCVNTPGSFM 465
C CR +C C G+ DN CED +DECA C+ C++ ++
Sbjct: 1093 CQHGGTCRGYMGGYMCECLPGYNG---DN--CEDDVDECAS--QPCQHGGSCIDLVARYL 1145
Query: 466 CICKTGYIRIDDYSCT-EHDEC-----ITNQHNCDENALCFNTVGGHNCVCKPGYTGNGT 519
C C G + + C D+C + + C N C + VGG C C PGYTG
Sbjct: 1146 CSCPPGTLGV---LCEINEDDCGPGPPLDSGPRCLHNGTCVDLVGGFRCTCPPGYTG--L 1200
Query: 520 TCKAFCKDGCRNGGACIAANV------------CACPQGFTGPSCETDIDECSDGFVQCD 567
C+A + CR+G AC AA+ C C GF+GP C+T + C C
Sbjct: 1201 RCEADINE-CRSG-ACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQTVLSPCES--QPCQ 1256
Query: 568 SRANCINLPG-----WYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNL 622
C PG + C C + G CE + C C
Sbjct: 1257 HGGQCRPSPGPGGGLTFTCHCAQPFW--------GPRCERVAR-SCRELQCPVGVPCQQT 1307
Query: 623 DGGYDCRCPHGKN-------------------CTGDCIHDGKVKHNGQIWVLENDRCSVC 663
G C CP G + C+H G + C
Sbjct: 1308 PRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFR------C 1361
Query: 664 SCQNGFV-----------------MCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGE 706
+C G+ C R C + D C EC+ S C G+
Sbjct: 1362 ACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRG--DQRCDRECN---SPGCGWDGGD 1416
Query: 707 TLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQAD 763
+ GD W +QC LQ CW L + C P C + C D
Sbjct: 1417 CSLSVGDPW----RQCEALQ----CWRL-----------FNNSRCDPACSSPACLYD 1454
Score = 93.2 bits (230), Expect = 9e-19
Identities = 116/456 (25%), Positives = 162/456 (35%), Gaps = 108/456 (23%)
Query: 444 CAEGRHYCRENTMCVNTPG-SFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNT 502
C +G C C P C+C G++ C D C + C +C ++
Sbjct: 43 CLDGSP-CANGGRCTQLPSREAACLCPPGWV---GERCQLEDPCHSGP--CAGRGVCQSS 96
Query: 503 V----GGHNCVCKPGYTGNGTTCKAFCKDG-CRNGGACIAAN----VCACPQGFTGPSCE 553
V +C C G+ G + C C +G C +C+CP G+ G SC
Sbjct: 97 VVAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCR 156
Query: 554 TDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPS----------------- 596
+D+DEC G C C+N PG + C+C GY +P+
Sbjct: 157 SDVDECRVG-EPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQS 215
Query: 597 --------------GESCE-DIDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTG 638
G++CE ++D+C H C N C + Y+C+CP G+ CT
Sbjct: 216 GDLTYDCACLPGFEGQNCEVNVDDC--PGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTE 273
Query: 639 D---CIHDGKVKHNGQIWVLENDRCSVCSCQNGFV--MCRRMVCDCENPTVDLFCCPECD 693
D C HNG S C C NG+ C + + DC T F C
Sbjct: 274 DVDECQLQPNACHNGGTCFNTLGGHS-CVCVNGWTGESCSQNIDDC--ATAVCFHGATCH 330
Query: 694 PRLSS-QCLHQNGET--LYNSGDTWVQN-CQQ--------------CRCLQG-------- 727
R++S C G+T L + D V N C + C C G
Sbjct: 331 DRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQ 390
Query: 728 ---EVDCWPLPCPD----VECEFSILPE---NECCPRCVTD--PCQADTIRNDITKTCLD 775
E PC V + S L + PRC TD C + RN TCLD
Sbjct: 391 DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQ--ATCLD 448
Query: 776 EMN------VVRFTGSSWIKHGTECTLCQCKNGHIC 805
+ + FTG+ EC C NG +C
Sbjct: 449 RIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVC 484
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 147 bits (370), Expect = 5e-35
Identities = 167/605 (27%), Positives = 230/605 (38%), Gaps = 142/605 (23%)
Query: 288 IDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEG--- 344
ID C N C NG + + + N CP + G+ C E C Q G
Sbjct: 261 IDDCPNHRCQNGGVCVDGVNTYNCRCPPQWT-----GQFCTEDVDECLLQPNACQNGGTC 315
Query: 345 -ERNTVYSSSGVCVLY----ECKDQTMKLVESSGCPALDCPESHQITLSHSC-CKVCKGY 398
RN Y VCV +C + +S P C + S SC C K
Sbjct: 316 ANRNGGYGC--VCVNGWSGDDCSENIDDCAFASCTPGSTCIDR---VASFSCMCPEGKAG 370
Query: 399 DFCSERHNCMEN-----SICRN--LNDRAVCSCRDGFRALREDNAYC-EDIDECAEGR-H 449
C C+ N ++C LN + +C+C G++ A C ED+DECA +
Sbjct: 371 LLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKG-----ADCTEDVDECAMANSN 425
Query: 450 YCRENTMCVNTPGSFMCICKTGYIRIDDYSCT-EHDECITNQHNCDENALCFNTVGGHNC 508
C CVNT G+F C C GY C + +EC ++ C +A C + +GG C
Sbjct: 426 PCEHAGKCVNTDGAFHCECLKGYA---GPRCEMDINECHSDP--CQNDATCLDKIGGFTC 480
Query: 509 VCKPGYTGNGTTCKAFCKD----GCRNGGACIAAN---VCACPQGFTGPSCETDIDECSD 561
+C PG+ G C+ + C N G C+ C CP GFTGP C+ DID+CS
Sbjct: 481 LCMPGF--KGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSS 538
Query: 562 GFVQCDSRANCINLPGWYHCECRDGYH--------DNGMFSP------------------ 595
C + A CI+ P Y C+C G+ DN P
Sbjct: 539 --TPCLNGAKCIDHPNGYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICN 596
Query: 596 ---SGESCED-IDECGTGRHSCANDTICFNLDGGYDCRC---PHGKNC--------TGDC 640
G C D IDEC + C ND C +L GY C C G NC + C
Sbjct: 597 PGYMGAICSDQIDECYSS--PCLNDGRCIDLVNGYQCNCQPGTSGVNCEINFDDCASNPC 654
Query: 641 IH----DGKVKHN--------GQIWVLENDRCSVCSCQNGFVMCRRMV----CDCENPTV 684
IH DG +++ GQ ++ D C+ C+ G C V C C
Sbjct: 655 IHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKG-ATCINGVNGFRCICPEGPH 713
Query: 685 DLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFS 744
C + + LS+ C+H N T + +C C G V + CE
Sbjct: 714 HPSCYSQVNECLSNPCIHGN--------CTGGLSGYKCLCDAGWV--------GINCE-- 755
Query: 745 ILPENECCPRCVTDPCQ----ADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCK 800
+ +NE C+++PCQ D + N TC F G + + EC C
Sbjct: 756 -VDKNE----CLSNPCQNGGTCDNLVNGYRCTCKK-----GFKGYNCQVNIDECASNPCL 805
Query: 801 NGHIC 805
N C
Sbjct: 806 NQGTC 810
Score = 134 bits (338), Expect = 3e-31
Identities = 154/618 (24%), Positives = 224/618 (36%), Gaps = 133/618 (21%)
Query: 271 ERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKEC 330
E TC + G T +E + W D C + C NG+ C T + C L G+ C+
Sbjct: 130 ECTCQV-GFTGKECQ-WTDACLSHPCANGS-TC-TTVANQFSC---KCLTGFTGQKCETD 182
Query: 331 KSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHS 390
+ C G G + S Y+C Q + C +L P + ++
Sbjct: 183 VNECDIPGHCQHGGTCLNLPGS------YQC--QCPQGFTGQYCDSLYVPCAPSPCVNGG 234
Query: 391 CCKVCKGYDFCSERHNCM---ENSIC-RNLNDRAVCSCRDGFRALREDNAY--------- 437
C+ + F NC+ E S C RN++D C++G + N Y
Sbjct: 235 TCRQTGDFTF---ECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGVNTYNCRCPPQWT 291
Query: 438 ----CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEH-DECITNQHN 492
ED+DEC + C+ C N G + C+C G+ D C+E+ D+C +
Sbjct: 292 GQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDD---CSENIDDCAF--AS 346
Query: 493 CDENALCFNTVGGHNCVCKPGYTGNGTTCKAFC-KDGCRNGGAC-----IAANVCACPQG 546
C + C + V +C+C G G C + C G C +C CPQG
Sbjct: 347 CTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQG 406
Query: 547 FTGPSCETDIDECS-DGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE-DID 604
+ G C D+DEC+ C+ C+N G +HCEC GY +G CE DI+
Sbjct: 407 YKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGY--------AGPRCEMDIN 458
Query: 605 ECGTGRHSCANDTICFNLDGGYDCRCP---HGKNC--------TGDCIHDG----KVKH- 648
EC + C ND C + GG+ C C G +C + C+++G KV
Sbjct: 459 ECHS--DPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDKVNRF 516
Query: 649 --------NGQIWVLENDRCSVCSCQNGFVMC----RRMVCDCENPTVDLFC---CPECD 693
G + ++ D CS C NG C C C + C CD
Sbjct: 517 QCLCPPGFTGPVCQIDIDDCSSTPCLNG-AKCIDHPNGYECQCATGFTGVLCEENIDNCD 575
Query: 694 PRLSSQCLHQNGETLY----NSG------DTWVQNCQQCRCLQG----------EVDCWP 733
P Q+G Y N G + C CL + +C P
Sbjct: 576 PDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQP 635
Query: 734 LPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR------FTGSSW 787
V CE + C ++PC I C+D +N FTG
Sbjct: 636 -GTSGVNCEINF-------DDCASNPC--------IHGICMDGINRYSCVCSPGFTGQRC 679
Query: 788 IKHGTECTLCQCKNGHIC 805
EC C+ G C
Sbjct: 680 NIDIDECASNPCRKGATC 697
Score = 116 bits (290), Expect = 1e-25
Identities = 137/540 (25%), Positives = 187/540 (34%), Gaps = 116/540 (21%)
Query: 288 IDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERN 347
I+ C + CLN + L CPL GK C+ ++C
Sbjct: 1026 INECSSHPCLNEGTCVDGLGTYRCSCPLGYT-----GKNCQTLVNLCS-----------R 1069
Query: 348 TVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNC 407
+ + G CV + + Q + SG C + + C + H C
Sbjct: 1070 SPCKNKGTCVQKKAESQCLC---PSGWAGAYCD------VPNVSCDIAASRRGVLVEHLC 1120
Query: 408 MENSICRNLNDRAVCSCRDGFRALREDNAYCED-IDECAEGRHYCRENTMCVNTPGSFMC 466
+ +C N + C C G+ +YCE+ +DECA C+ C + G + C
Sbjct: 1121 QHSGVCINAGNTHYCQCPLGYTG-----SYCEEQLDECASNP--CQHGATCSDFIGGYRC 1173
Query: 467 ICKTGYIRID-DYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFC 525
C GY ++ +Y E DEC C C + V C C PG G C+
Sbjct: 1174 ECVPGYQGVNCEY---EVDEC--QNQPCQNGGTCIDLVNHFKCSCPPGT--RGLLCEENI 1226
Query: 526 KD-----GCRNGGAC---IAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPG 577
D C NGG C I C C GF G CE DI+EC + +CI L
Sbjct: 1227 DDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEGSLDCIQLTN 1286
Query: 578 WYHCECRDGYHDNGMFSPSGESCED-IDECGTGRHSCANDTIC---FNLDGGYDCRCP-- 631
Y C CR + +G CE +D C + C N C N+ G+ CRCP
Sbjct: 1287 DYLCVCRSAF--------TGRHCETFVDVC--PQMPCLNGGTCAVASNMPDGFICRCPPG 1336
Query: 632 -HGKNCTGDCIHDGKVK-HNGQ--IWVLENDRC---SVCSCQNGFVM--CRR-------- 674
G C C G+VK G+ + RC S C++G C+
Sbjct: 1337 FSGARCQSSC---GQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQR 1393
Query: 675 ----MVCDCENP----TVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQ 726
C C P +L+ P P + CL Q G + C C
Sbjct: 1394 QPPYYSCQCAPPFSGSRCELYTAPPSTP--PATCLSQYCADKARDG-VCDEACNSHACQW 1450
Query: 727 GEVDC-------W-----PLPCPDVECEFSILPENECCPRCVTDPCQADTIR-NDITKTC 773
DC W PLPC D N+C C T C D +KTC
Sbjct: 1451 DGGDCSLTMENPWANCSSPLPCWD-------YINNQCDELCNTVECLFDNFECQGNSKTC 1503
Score = 112 bits (280), Expect = 1e-24
Identities = 131/498 (26%), Positives = 181/498 (36%), Gaps = 122/498 (24%)
Query: 407 CMENSICRNL-NDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTP--GS 463
C+ +C N C C +GF YC+ D C + R C+ CV G
Sbjct: 35 CVNEGMCVTYHNGTGYCKCPEGFLG-----EYCQHRDPCEKNR--CQNGGTCVAQAMLGK 87
Query: 464 FMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKA 523
C C +G+ D T H C ++ + + + C C+ G+TG
Sbjct: 88 ATCRCASGFTGEDCQYSTSHP-CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD 146
Query: 524 FC-KDGCRNGGACIA-ANV--CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWY 579
C C NG C AN C C GFTG CETD++EC D C C+NLPG Y
Sbjct: 147 ACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNEC-DIPGHCQHGGTCLNLPGSY 205
Query: 580 HCECRDGY---HDNGMFSP----------------------------SGESCE-DIDECG 607
C+C G+ + + ++ P G +CE +ID+C
Sbjct: 206 QCQCPQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDC- 264
Query: 608 TGRHSCANDTICFNLDGGYDCRCP---HGKNCTGD---CIHDGKVKHNGQIWVLENDRCS 661
H C N +C + Y+CRCP G+ CT D C+ NG N
Sbjct: 265 -PNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYG 323
Query: 662 VCSCQNGFV--MCRRMVCDCENPTVDLFCCP--ECDPRLSS-QCLHQNGET--LYNSGDT 714
C C NG+ C + DC + C P C R++S C+ G+ L + D
Sbjct: 324 -CVCVNGWSGDDCSENIDDCAFAS----CTPGSTCIDRVASFSCMCPEGKAGLLCHLDDA 378
Query: 715 WVQN-CQQ--------------CRCLQG--EVDCWPLPCPDVECEFSILPENEC-----C 752
+ N C + C C QG DC DV+ E ++ N C C
Sbjct: 379 CISNPCHKGALCDTNPLNGQYICTCPQGYKGADC----TEDVD-ECAMANSNPCEHAGKC 433
Query: 753 -----------------PRCVTD--PCQADTIRNDITKTCLDEMN------VVRFTGSSW 787
PRC D C +D +ND TCLD++ + F G
Sbjct: 434 VNTDGAFHCECLKGYAGPRCEMDINECHSDPCQND--ATCLDKIGGFTCLCMPGFKGVHC 491
Query: 788 IKHGTECTLCQCKNGHIC 805
EC C N C
Sbjct: 492 ELEINECQSNPCVNNGQC 509
Score = 93.6 bits (231), Expect = 7e-19
Identities = 106/441 (24%), Positives = 161/441 (36%), Gaps = 84/441 (19%)
Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSFM 465
C C NL + C+C+ GF+ C+ +IDECA C C + +
Sbjct: 766 CQNGGTCDNLVNGYRCTCKKGFKGYN-----CQVNIDECASNP--CLNQGTCFDDISGYT 818
Query: 466 CICKTGYIRIDDYSC-TEHDECITNQHNCDENALCFNTVG--GHNCVCKPGYTGNGTTCK 522
C C Y +C T C N C+ A+C + + C+C PG+ G T
Sbjct: 819 CHCVLPYT---GKNCQTVLAPCSPNP--CENAAVCKESPNFESYTCLCAPGWQGQRCTID 873
Query: 523 A--FCKDGCRNGGACI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPG 577
C N G C + +C CP GF+G CE DID+C C + +C++
Sbjct: 874 IDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDCLAN--PCQNGGSCMDGVN 931
Query: 578 WYHCECRDGYHDNGMFSPSGESCE-DIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNC 636
+ C C G+ +G+ C+ D++EC + C N C + Y C+C G
Sbjct: 932 TFSCLCLPGF--------TGDKCQTDMNECLS--EPCKNGGTCSDYVNSYTCKCQAG--- 978
Query: 637 TGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVM---CRRMVCDCENPTVDLFCCPECD 693
DG N + C+ SC NG C C FC E +
Sbjct: 979 -----FDGVHCEN------NINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEIN 1027
Query: 694 PRLSSQCLHQNGETLYNSGDTWVQNC------QQCRCLQGEVDCWPLPCPDVECEFSILP 747
S CL++ T + T+ +C + C+ L C PC +
Sbjct: 1028 ECSSHPCLNEG--TCVDGLGTYRCSCPLGYTGKNCQTLVNL--CSRSPCKNKGTCVQKKA 1083
Query: 748 ENEC-CPRCVTDP-CQADTIRNDITKT---------------CLDEMNV------VRFTG 784
E++C CP C + DI + C++ N + +TG
Sbjct: 1084 ESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTG 1143
Query: 785 SSWIKHGTECTLCQCKNGHIC 805
S + EC C++G C
Sbjct: 1144 SYCEEQLDECASNPCQHGATC 1164
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 147 bits (370), Expect = 5e-35
Identities = 99/287 (34%), Positives = 124/287 (43%), Gaps = 38/287 (13%)
Query: 371 SSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRA 430
S G + CP + S C D C+ + C + C N CSC G
Sbjct: 5084 SKGDRSNQCPSGFTLD---SVGPFCADEDECAAGNPCSHS--CHNAMGTYYCSCPKGL-T 5137
Query: 431 LREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCI--CKTGYIRIDD-YSCTEHDECI 487
+ D C+DIDECA GRH C C NT GS+ C+ C +G+ R D SC + +EC
Sbjct: 5138 IAADGRTCQDIDECALGRHTCHAGQDCDNTIGSYRCVVRCGSGFRRTSDGLSCQDINEC- 5196
Query: 488 TNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCK-------------AFCKDGCRNGGA 534
Q + + CFN +G +C C+PGY G C CK+ R G
Sbjct: 5197 --QESSPCHQRCFNAIGSFHCGCEPGYQLKGRKCMDVNECRQNVCRPDQHCKN-TRGGYK 5253
Query: 535 CIAANVCACPQGFTGPSCET--DIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGM 592
CI CP G T T DIDEC DG QC C N G Y C C GY G+
Sbjct: 5254 CIDL----CPNGMTKAENGTCIDIDECKDGTHQCRYNQICENTRGSYRCVCPRGYRSQGV 5309
Query: 593 FSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGD 639
G C DI+EC CA+ C N G + C CP G++ GD
Sbjct: 5310 ----GRPCMDINECEQVPKPCAHQ--CSNTPGSFKCICPPGQHLLGD 5350
Score = 97.1 bits (240), Expect = 6e-20
Identities = 110/436 (25%), Positives = 163/436 (37%), Gaps = 67/436 (15%)
Query: 293 NCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTVYSS 352
+C GT C CP +A DG+ C++ C T G+
Sbjct: 5120 SCHNAMGTYYCS--------CPKGLTIA-ADGRTCQDIDE-CALGRHTCHAGQDCDNTIG 5169
Query: 353 SGVCVLYECKDQTMKLVESSGCPAL-DCPES---HQ-----ITLSHSCCKVCKGYDF--- 400
S CV+ C + + C + +C ES HQ I H C+ GY
Sbjct: 5170 SYRCVV-RCGSGFRRTSDGLSCQDINECQESSPCHQRCFNAIGSFHCGCE--PGYQLKGR 5226
Query: 401 -CSERHNCMENSICRNLNDRAVCSCRDGFRAL--------REDNAYCEDIDECAEGRHYC 451
C + + C +N +CR D+ + R G++ + + +N C DIDEC +G H C
Sbjct: 5227 KCMDVNECRQN-VCRP--DQHCKNTRGGYKCIDLCPNGMTKAENGTCIDIDECKDGTHQC 5283
Query: 452 RENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
R N +C NT GS+ C+C GY + C + +EC C C NT G C+C
Sbjct: 5284 RYNQICENTRGSYRCVCPRGYRSQGVGRPCMDINECEQVPKPCAHQ--CSNTPGSFKCIC 5341
Query: 511 KPG--YTGNGTTCKAFCKDGCRNGGACIA----ANVCACPQGFTGPSCETDIDECSDGFV 564
PG G+G +C + N G + A + +
Sbjct: 5342 PPGQHLLGDGKSCAGL--ERLPNYGTQYSSYNLARFSPVRNNYQPQQHYRQYSHLYSSYS 5399
Query: 565 QC-DSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLD 623
+ +SR + C +G S ++C DIDEC +C ++ C N
Sbjct: 5400 EYRNSRTSLSRTRRTIRKTCPEG------SEASHDTCVDIDEC-ENTDACQHE--CKNTF 5450
Query: 624 GGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS---VCSCQNGFVMCRRMVC--D 678
G Y C CP G T H+GK + + +N C +C G C C +
Sbjct: 5451 GSYQCICPPGYQLT----HNGKTCQDIDECLEQNVHCGPNRMCFNMRGSYQCIDTPCPPN 5506
Query: 679 CENPTVDLFCCPECDP 694
+ V FC C P
Sbjct: 5507 YQRDPVSGFCLKNCPP 5522
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 146 bits (368), Expect = 9e-35
Identities = 152/595 (25%), Positives = 224/595 (37%), Gaps = 124/595 (20%)
Query: 267 QCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKC 326
+C C + G T + E ID C C NG + + N CP + G+
Sbjct: 242 ECAC-----LPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWT-----GQY 291
Query: 327 CKECKSICQFQGRTYFEGE--RNTVYSSSGVCVL-YECKDQTMKLVESSGCPALDCPESH 383
C E CQ G NT + VCV + +D + + + + H
Sbjct: 292 CTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCH 351
Query: 384 QITLSHSC-CK------VCKGYDFCSERHNCMENSIC--RNLNDRAVCSCRDGFRALRED 434
S C C +C D C + C E S C +N +A+C+C G+
Sbjct: 352 DRVASFYCECPHGRTGLLCHLNDACIS-NPCNEGSNCDTNPVNGKAICTCPSGYTG---- 406
Query: 435 NAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCD 494
A +D+DEC+ G + C C+NT GSF C C GY + +EC++N C
Sbjct: 407 PACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGY--TGPRCEIDVNECVSNP--CQ 462
Query: 495 ENALCFNTVGGHNCVCKPGYTG-----NGTTCKAFCKDGCRNGGAC---IAANVCACPQG 546
+A C + +G C+C PGY G N C C + G C I C CP G
Sbjct: 463 NDATCLDQIGEFQCICMPGYEGVHCEVNTDEC---ASSPCLHNGRCLDKINEFQCECPTG 519
Query: 547 FTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE-DIDE 605
FTG C+ D+DEC+ C + A C++ P Y C C +GY +G CE DIDE
Sbjct: 520 FTGHLCQYDVDECAS--TPCKNGAKCLDGPNTYTCVCTEGY--------TGTHCEVDIDE 569
Query: 606 C-------GTGRHSCANDT-ICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLEN 657
C G+ + A T +C G+ C + + C H G + +
Sbjct: 570 CDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQ--------DR 621
Query: 658 DRCSVCSCQNGFV--MCRRMVCDCENPTVDLFCCPE--------CDPRLSSQCLHQN--- 704
D +C C G C + DC + D C + C+P + + N
Sbjct: 622 DNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDE 681
Query: 705 --GETLYNSGDTWVQNCQQ------CRCLQGEVDCWPLPCPDVECEFSILPENECCPRCV 756
G +N G C+ CRC +G D P +V C
Sbjct: 682 CAGNPCHNGG-----TCEDGINGFTCRCPEGYHD--PTCLSEVN-------------ECN 721
Query: 757 TDPCQADTIRNDITKTCLDEMNVVR------FTGSSWIKHGTECTLCQCKNGHIC 805
++PC + C D +N + ++G++ + EC C NG C
Sbjct: 722 SNPC--------VHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTC 768
Score = 126 bits (317), Expect = 7e-29
Identities = 114/436 (26%), Positives = 167/436 (38%), Gaps = 87/436 (19%)
Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSFM 465
C+ N C + + C C GF C+ D+DECA C+ C++ P ++
Sbjct: 499 CLHNGRCLDKINEFQCECPTGFTG-----HLCQYDVDECASTP--CKNGAKCLDGPNTYT 551
Query: 466 CICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNG--TTCKA 523
C+C GY + + DEC + C + C + V C+C+PGYTG+ T
Sbjct: 552 CVCTEGYT--GTHCEVDIDEC--DPDPCHYGS-CKDGVATFTCLCRPGYTGHHCETNINE 606
Query: 524 FCKDGCRNGGACIA---ANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYH 580
CR+GG C A +C C +G TGP+CE ++D+C+ CDS C++ Y
Sbjct: 607 CSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASS--PCDS-GTCLDKIDGYE 663
Query: 581 CECRDGYHDNGMFSPSGESCE-DIDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNC 636
C C GY +G C +IDEC + C N C + G+ CRCP H C
Sbjct: 664 CACEPGY--------TGSMCNINIDEC--AGNPCHNGGTCEDGINGFTCRCPEGYHDPTC 713
Query: 637 TGD--------CIH------------DGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRM- 675
+ C+H D +G + N+ C C NG C+ M
Sbjct: 714 LSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGT-CKDMT 772
Query: 676 ---VCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNC--QQCRCLQGEVD 730
VC C C + S+ CL+Q T + + +C CL
Sbjct: 773 SGYVCTCREGFSGPNCQTNINECASNPCLNQG---------TCIDDVAGYKCNCL----- 818
Query: 731 CWPLPCPDVECEFSILPENECCPRCVTDPCQ-ADTIRNDITKTCLDEMNVVRFTGSSWIK 789
LP CE + P C PC+ R + + G +
Sbjct: 819 ---LPYTGATCEVVLAP-------CAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEV 868
Query: 790 HGTECTLCQCKNGHIC 805
EC L C++G C
Sbjct: 869 DINECVLSPCRHGASC 884
Score = 120 bits (300), Expect = 7e-27
Identities = 127/498 (25%), Positives = 179/498 (35%), Gaps = 131/498 (26%)
Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSFM 465
C C + + A C C GFR +CE DI+ECA CR C + S+
Sbjct: 916 CHNGGSCTDGINTAFCDCLPGFRG-----TFCEEDINECASDP--CRNGANCTDCVDSYT 968
Query: 466 CICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFC 525
C C G+ I E++ + +C C + + C+C PG+TG+ +C
Sbjct: 969 CTCPAGFSGIH----CENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGS------YC 1018
Query: 526 KDG--------CRNGGAC---IAANVCACPQGFTGPSCETDID----------------- 557
+ C +GG C + C CPQG+TGP+C+ +
Sbjct: 1019 QHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTH 1078
Query: 558 -----ECSDGF---------VQCDSRAN---------------CINLPGWYHCECRDGYH 588
EC G+ V C+ A C++ +HC C+ GY
Sbjct: 1079 TQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGY- 1137
Query: 589 DNGMFSPSGESCED-IDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTGDCIHDG 644
+G CED +DEC C N C + GGY C+C HG NC+ + D
Sbjct: 1138 -------TGSYCEDLVDECSPS--PCQNGATCTDYLGGYSCKCVAGYHGVNCSEEI--DE 1186
Query: 645 KVKH---NGQIWVLENDRCSVCSCQNGF--VMCRRMVCDCENPTVDLFCCPECDPRLSSQ 699
+ H NG L+ CSC G V C V DC P + P+C +
Sbjct: 1187 CLSHPCQNGGT-CLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFN--NGT 1243
Query: 700 CLHQNGETLYNSGDTWVQNCQQCRCLQGEV-DCWPLPCP------------DVECEFSIL 746
C+ Q G +V RC +G+V +C PC D CE
Sbjct: 1244 CVDQVGGYSCTCPPGFVGE----RC-EGDVNECLSNPCDARGTQNCVQRVNDFHCECRAG 1298
Query: 747 PENECCPRCVTDPCQADTIRNDITKTCLDEMNVVR---------FTGSSWIKHGTECTLC 797
C V + C+ +N TC N R F G++ C
Sbjct: 1299 HTGRRC-ESVINGCKGKPCKNG--GTCAVASNTARGFICKCPAGFEGATCENDARTCGSL 1355
Query: 798 QCKNGHICCS--VDPQCL 813
+C NG C S P CL
Sbjct: 1356 RCLNGGTCISGPRSPTCL 1373
Score = 119 bits (298), Expect = 1e-26
Identities = 94/331 (28%), Positives = 127/331 (38%), Gaps = 70/331 (21%)
Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCED-IDECAEGRHYCRENTMCVNTPGSFM 465
C +C + + C C+ G+ +YCED +DEC+ C+ C + G +
Sbjct: 1116 CQHGGLCVDAGNTHHCRCQAGYTG-----SYCEDLVDECSPSP--CQNGATCTDYLGGYS 1168
Query: 466 CICKTGYIRIDDYSCTEH-DECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAF 524
C C GY ++ C+E DEC++ H C C + + C C G G C+
Sbjct: 1169 CKCVAGYHGVN---CSEEIDECLS--HPCQNGGTCLDLPNTYKCSCPRGT--QGVHCEIN 1221
Query: 525 CKD------------GCRNGGACI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
D C N G C+ C CP GF G CE D++EC CD+R
Sbjct: 1222 VDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSN--PCDAR 1279
Query: 570 A--NCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTIC---FNLDG 624
NC+ +HCECR G+ +G CE + G+ C N C N
Sbjct: 1280 GTQNCVQRVNDFHCECRAGH--------TGRRCESVINGCKGK-PCKNGGTCAVASNTAR 1330
Query: 625 GYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMC---RRMVCDCEN 681
G+ C+CP G C +D + C C NG R C C
Sbjct: 1331 GFICKCPAGFE-GATCENDART-------------CGSLRCLNGGTCISGPRSPTCLCLG 1376
Query: 682 PTVDLFCCPECDPRLSSQCLHQNGETLYNSG 712
P F PEC SS CL G YN G
Sbjct: 1377 P----FTGPECQFPASSPCL--GGNPCYNQG 1401
Score = 115 bits (289), Expect = 1e-25
Identities = 123/451 (27%), Positives = 172/451 (38%), Gaps = 119/451 (26%)
Query: 409 ENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSFMCI 467
++ C + D C+C G+ + C +IDECA C C + F C
Sbjct: 651 DSGTCLDKIDGYECACEPGYTG-----SMCNINIDECAGNP--CHNGGTCEDGINGFTCR 703
Query: 468 CKTGYIRIDDYSC-TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG-----NGTTC 521
C GY D +C +E +EC N + C A C +++ G+ C C PG++G N C
Sbjct: 704 CPEGY---HDPTCLSEVNEC--NSNPCVHGA-CRDSLNGYKCDCDPGWSGTNCDINNNEC 757
Query: 522 KAFCKDGCRNGGAC---IAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGW 578
++ + C NGG C + VC C +GF+GP+C+T+I+EC+ C ++ CI+
Sbjct: 758 ES---NPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASN--PCLNQGTCIDDVAG 812
Query: 579 YHCE---------------------CRDG--------YHDNGMFSPS---GESCE-DIDE 605
Y C CR+G Y P+ G++CE DI+E
Sbjct: 813 YKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINE 872
Query: 606 CGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTGDCIHDGKVK--HNGQIWVLENDRC 660
C C + C N GGY C C G+NC D I D + HNG
Sbjct: 873 CVLS--PCRHGASCQNTHGGYRCHCQAGYSGRNCETD-IDDCRPNPCHNGG--------- 920
Query: 661 SVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQ 720
SC +G CDC FC + + S C +NG NC
Sbjct: 921 ---SCTDGI---NTAFCDCLPGFRGTFCEEDINECASDPC--RNG-----------ANCT 961
Query: 721 QCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVV 780
C VD + CP FS + P C C TC+D +N
Sbjct: 962 DC------VDSYTCTCP---AGFSGIHCENNTPDCTESSCFNG-------GTCVDGINSF 1005
Query: 781 R------FTGSSWIKHGTECTLCQCKNGHIC 805
FTGS EC C +G C
Sbjct: 1006 TCLCPPGFTGSYCQHDVNECDSQPCLHGGTC 1036
Score = 111 bits (277), Expect = 3e-24
Identities = 125/492 (25%), Positives = 177/492 (35%), Gaps = 140/492 (28%)
Query: 403 ERHNCMENSICRNLNDRAVCSCRDGFRA-------------------------------- 430
E + C+ C+++ VC+CR+GF
Sbjct: 758 ESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNC 817
Query: 431 -LREDNAYCEDI-DECAEGRHYCRENTMCVNTPG--SFMCICKTGYIRIDDYSC-TEHDE 485
L A CE + CA CR C + SF C+C TG+ +C + +E
Sbjct: 818 LLPYTGATCEVVLAPCAPSP--CRNGGECRQSEDYESFSCVCPTGW---QGQTCEVDINE 872
Query: 486 CITNQHNCDENALCFNTVGGHNCVCKPGYTG-NGTTCKAFCK-DGCRNGGAC---IAANV 540
C+ + C A C NT GG+ C C+ GY+G N T C+ + C NGG+C I
Sbjct: 873 CVLSP--CRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAF 930
Query: 541 CACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
C C GF G CE DI+EC+ C + ANC + Y C C G+ SG C
Sbjct: 931 CDCLPGFRGTFCEEDINECASD--PCRNGANCTDCVDSYTCTCPAGF--------SGIHC 980
Query: 601 E-DIDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTGD--------CIHDGKVKH 648
E + +C SC N C + + C CP G C D C+H G +
Sbjct: 981 ENNTPDC--TESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQ- 1037
Query: 649 NGQIWVLENDRCSV--CSCQNGFV--MCRRMV----------------------CDCENP 682
D C C+C G+ C+ +V C+C +
Sbjct: 1038 ---------DGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSG 1088
Query: 683 TVDLFC-CPECDPRLSSQCLHQNGETLYNSGDTWVQ--NCQQCRCLQGEVDCWPLPCPDV 739
L+C P +++Q + L G V N CRC G + C D+
Sbjct: 1089 WTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSY---CEDL 1145
Query: 740 ECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMN------VVRFTGSSWIKHGTE 793
+EC P PCQ TC D + V + G + + E
Sbjct: 1146 --------VDECSP----SPCQNGA-------TCTDYLGGYSCKCVAGYHGVNCSEEIDE 1186
Query: 794 CTLCQCKNGHIC 805
C C+NG C
Sbjct: 1187 CLSHPCQNGGTC 1198
Score = 97.1 bits (240), Expect = 6e-20
Identities = 119/469 (25%), Positives = 166/469 (35%), Gaps = 113/469 (24%)
Query: 401 CSER-HNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMC-- 457
CS+ C+ C N C C F R C+D + C C+ C
Sbjct: 24 CSQPGETCLNGGKCEAANGTEACVCGGAFVGPR-----CQDPNPCLSTP--CKNAGTCHV 76
Query: 458 VNTPG--SFMCICKTGYIRIDDYSCTEHDE-CITNQHNCDENALC-FNTVGGHNCVCKPG 513
V+ G + C C G+ T D C+TN C C T+ + C C PG
Sbjct: 77 VDRRGVADYACSCALGFS--GPLCLTPLDNACLTNP--CRNGGTCDLLTLTEYKCRCPPG 132
Query: 514 YTGNGTTCKAFCKDG-CRNGGACI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
++G C C NGG C+ A+ +C CP F GP+C D++EC C
Sbjct: 133 WSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHG 192
Query: 570 ANCINLPGWYHCECRDGY-----------------HDNGMFSP--------------SGE 598
C N G Y C CR + + G P +G+
Sbjct: 193 GTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQ 252
Query: 599 SCED-IDECGTGRHSCANDTICFNLDGGYDCRCP---HGKNCTGD----------CIHDG 644
+CE+ ID+C ++C N C + Y+CRCP G+ CT D C + G
Sbjct: 253 NCEENIDDC--PGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGG 310
Query: 645 KV--KHNGQIWVLEN-----------DRCSVCSCQNGFVMCRRMV---CDCENPTVDLFC 688
H G V N D C+ +C +G R+ C+C + L C
Sbjct: 311 TCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLC 370
Query: 689 CPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQG--------EVDCWPL---PCP 737
L+ C+ N V C C G +VD L PC
Sbjct: 371 ------HLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCE 424
Query: 738 DVECEFSILPENEC-C------PRCVTD--PCQADTIRNDITKTCLDEM 777
+ L EC C PRC D C ++ +ND TCLD++
Sbjct: 425 HAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQND--ATCLDQI 471
Score = 80.1 bits (196), Expect = 8e-15
Identities = 124/524 (23%), Positives = 182/524 (34%), Gaps = 126/524 (24%)
Query: 266 DQCYCERTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVD-- 323
D C R +G T ++ + C + C NG +T +CP Y D
Sbjct: 1038 DGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVP 1097
Query: 324 GKCCK--------ECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCP 375
C+ + +CQ G G + +G Y C+D LV+ C
Sbjct: 1098 SVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSY-CED----LVDE--CS 1150
Query: 376 ALDCPESHQIT--LSHSCCKVCKGYDF--CSER------HNCMENSICRNLNDRAVCSCR 425
C T L CK GY CSE H C C +L + CSC
Sbjct: 1151 PSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCP 1210
Query: 426 DGFRALREDNAYCE-DIDEC------AEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDY 478
G + + +CE ++D+C C N CV+ G + C C G++ +
Sbjct: 1211 RGTQGV-----HCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFV--GER 1263
Query: 479 SCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG----------------NGTTCK 522
+ +EC++N + C V +C C+ G+TG NG TC
Sbjct: 1264 CEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCA 1323
Query: 523 -------------------AFCKDG--------CRNGGACIA---ANVCACPQGFTGPSC 552
A C++ C NGG CI+ + C C FTGP C
Sbjct: 1324 VASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPEC 1383
Query: 553 ETDIDECSDGFVQCDSRANC--INLPGWYHCECRDGYHDNGM------FSPSG------- 597
+ G C ++ C + +Y C C + NG+ +S G
Sbjct: 1384 QFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKF--NGLLCHILDYSFGGGAGRDIP 1441
Query: 598 -----ESCEDIDEC--GTGRHSCA---NDTICFNLDGGYDCRCPHG---KNCTGDCIHDG 644
E+CE + EC G C+ N+ C DGG DC KNCT +
Sbjct: 1442 PPLIEEACE-LPECQEDAGNKVCSLQCNNHAC-GWDGG-DCSLNFNDPWKNCT-QSLQCW 1497
Query: 645 KVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFC 688
K +G + +C+ C C+R C NP D +C
Sbjct: 1498 KYFSDGHC----DSQCNSAGCLFDGFDCQRAEGQC-NPLYDQYC 1536
>gi|40807489 egf-like module containing, mucin-like, hormone
receptor-like sequence 1 [Homo sapiens]
Length = 886
Score = 142 bits (359), Expect = 1e-33
Identities = 89/251 (35%), Positives = 118/251 (47%), Gaps = 41/251 (16%)
Query: 395 CKGYDFCSERHN-CMENSICRNLNDRAVCSCRDGFRAL--------REDNAYCEDIDECA 445
CK D CS+ C NS C+NL+ R CSC DGF + + N C DI+EC
Sbjct: 78 CKDIDECSQSPQPCGPNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECL 137
Query: 446 EGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGG 505
C E++ CVN+ GS+ C C+ G+I + +C + DEC + C E+A C NTVG
Sbjct: 138 TSS-VCPEHSDCVNSMGSYSCSCQVGFISRNS-TCEDVDEC-ADPRACPEHATCNNTVGN 194
Query: 506 HNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQ 565
++C C PG+ + QG SCE DIDEC++
Sbjct: 195 YSCFCNPGFESSSGHLSF---------------------QGLKA-SCE-DIDECTE---M 228
Query: 566 CDSRANCINLPGWYHCECRDGYH-DNGM--FSPSGESCEDIDECGTGRHSCANDTICFNL 622
C + C N PG Y C C G+ NG F+ G C DIDEC +C ++IC N
Sbjct: 229 CPINSTCTNTPGSYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSICTNA 288
Query: 623 DGGYDCRCPHG 633
G Y C C G
Sbjct: 289 LGSYSCGCIAG 299
Score = 90.1 bits (222), Expect = 7e-18
Identities = 59/183 (32%), Positives = 83/183 (45%), Gaps = 31/183 (16%)
Query: 359 YECKDQTMKLVESSGCPA-LDCPESHQITLSHSC-CKV--------CKGYDFCSERHNCM 408
+ C D + + SS CP DC S S+SC C+V C+ D C++ C
Sbjct: 128 FSCTDIN-ECLTSSVCPEHSDCVNSMG---SYSCSCQVGFISRNSTCEDVDECADPRACP 183
Query: 409 ENSICRNLNDRAVCSCRDGFRA------LREDNAYCEDIDECAEGRHYCRENTMCVNTPG 462
E++ C N C C GF + + A CEDIDEC E C N+ C NTPG
Sbjct: 184 EHATCNNTVGNYSCFCNPGFESSSGHLSFQGLKASCEDIDECTE---MCPINSTCTNTPG 240
Query: 463 SFMCICKTGY------IRIDDYS--CTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY 514
S+ C C G+ + D C + DEC + C N++C N +G ++C C G+
Sbjct: 241 SYFCTCHPGFAPSNGQLNFTDQGVECRDIDECRQDPSTCGPNSICTNALGSYSCGCIAGF 300
Query: 515 TGN 517
N
Sbjct: 301 HPN 303
Score = 65.1 bits (157), Expect = 3e-10
Identities = 48/154 (31%), Positives = 64/154 (41%), Gaps = 21/154 (13%)
Query: 557 DECSDGFVQCDSRANCINLPGWYHCECRDGY-HDNGM--FSPSGESCEDIDECGTGRHSC 613
+ C D + C + A C N Y+C C+ G+ NG F G C+DIDEC C
Sbjct: 33 NNCRDSTL-CPAYATCTNTVDSYYCACKQGFLSSNGQNHFKDPGVRCKDIDECSQSPQPC 91
Query: 614 ANDTICFNLDGGYDCRCPHG-KNCTGDCIHDGKVKHNGQIWVLENDRCSV---------- 662
++ C NL G Y C C G + TG+ GK + + E SV
Sbjct: 92 GPNSSCKNLSGRYKCSCLDGFSSPTGNDWVPGKPGNFSCTDINECLTSSVCPEHSDCVNS 151
Query: 663 -----CSCQNGFVMCRRMVCDCENPTVDLFCCPE 691
CSCQ GF+ R C+ + D CPE
Sbjct: 152 MGSYSCSCQVGFI-SRNSTCEDVDECADPRACPE 184
>gi|51873055 fibulin 2 isoform b precursor [Homo sapiens]
Length = 1184
Score = 139 bits (349), Expect = 1e-32
Identities = 115/400 (28%), Positives = 150/400 (37%), Gaps = 67/400 (16%)
Query: 401 CSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNT 460
C + C + +C + A+CSC G+ A+ D CEDI+EC H C CVNT
Sbjct: 683 CKDNGPCKQ--VCSTVGGSAICSCFPGY-AIMADGVSCEDINECVTDLHTCSRGEHCVNT 739
Query: 461 PGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG 516
GSF C C+ GY + D C + DEC H C LC NT G C
Sbjct: 740 LGSFHCYKALTCEPGY-ALKDGECEDVDECAMGTHTCQPGFLCQNTKGSFYC-------- 790
Query: 517 NGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLP 576
+ C DG P+G +C DI+EC+ C +CIN
Sbjct: 791 ---QARQRCMDGFLQD-----------PEG----NC-VDINECTSLSEPCRPGFSCINTV 831
Query: 577 GWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCP 631
G Y C+ C GYH S G C D++EC TG H C +C NL G Y C C
Sbjct: 832 GSYTCQRNPLICARGYH----ASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCK 887
Query: 632 HGKNCTGDCIHDGKVKHNGQIWVLENDRCS----------VCSCQNGFVMCR-RMVCDCE 680
G D G + N + W C CSC +GF++ C+
Sbjct: 888 AG--FQRDAFGRGCIDVN-ECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDV 944
Query: 681 NPTVDLFCCPECDPRLSS-QCLHQNGETLYNSGDTW--VQNCQQCRCLQGEVDCWPLP-- 735
N C EC S QC + G L G T + C Q + C +P
Sbjct: 945 NECEAQRCSQECANIYGSYQCYCRQGYQLAEDGHTCTDIDECAQGAGILCTFRCLNVPGS 1004
Query: 736 --CPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTC 773
C E +++ C D C T +TC
Sbjct: 1005 YQCACPEQGYTMTANGRSCKD--VDECALGTHNCSEAETC 1042
Score = 136 bits (343), Expect = 7e-32
Identities = 93/303 (30%), Positives = 134/303 (44%), Gaps = 76/303 (25%)
Query: 388 SHSC-----CKVCKGYDFCSERHNCMENSI------CRNLNDRAVCS--CRDGFRALR-- 432
+H+C C+ KG +C R CM+ + C ++N+ S CR GF +
Sbjct: 772 THTCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTV 831
Query: 433 -------------------EDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYI 473
+D C D++EC G H C E +C N PGS+ C CK G+
Sbjct: 832 GSYTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQ 891
Query: 474 RIDDY--SCTEHDECITN-----QHNCDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF 524
R D + C + +EC + QH C+ NT+G + C C G+ +G C+
Sbjct: 892 R-DAFGRGCIDVNECWASPGRLCQHTCE------NTLGSYRCSCASGFLLAADGKRCEDV 944
Query: 525 -------CKDGCRNGGACIAANVCACPQGF----TGPSCETDIDECSDGF-VQCDSRANC 572
C C N + C C QG+ G +C TDIDEC+ G + C R C
Sbjct: 945 NECEAQRCSQECAN---IYGSYQCYCRQGYQLAEDGHTC-TDIDECAQGAGILCTFR--C 998
Query: 573 INLPGWYHCEC-RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC--- 628
+N+PG Y C C GY + +G SC+D+DEC G H+C+ C N+ G + C
Sbjct: 999 LNVPGSYQCACPEQGY----TMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRF 1054
Query: 629 RCP 631
CP
Sbjct: 1055 ECP 1057
Score = 121 bits (303), Expect = 3e-27
Identities = 101/378 (26%), Positives = 149/378 (39%), Gaps = 104/378 (27%)
Query: 395 CKGYDFC-SERHNCMENSICRNLNDRAVC----SCRDGFRALREDNAYCEDIDECAEGRH 449
C+ + C ++ H C C N C +C G+ AL++ CED+DECA G H
Sbjct: 717 CEDINECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY-ALKDGE--CEDVDECAMGTH 773
Query: 450 YCRENTMCVNTPGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGG 505
C+ +C NT GSF C C G+++ + +C + +EC + C C NTVG
Sbjct: 774 TCQPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCVDINECTSLSEPCRPGFSCINTVGS 833
Query: 506 HNC-----VCKPGY--TGNGTTC--------------------------KAFCKDGCRN- 531
+ C +C GY + +GT C + CK G +
Sbjct: 834 YTCQRNPLICARGYHASDDGTKCVDVNECETGVHRCGEGQVCHNLPGSYRCDCKAGFQRD 893
Query: 532 --GGACIAANVC-ACPQGFTGPSCETDID----ECSDGFV------------QCDSR--- 569
G CI N C A P +CE + C+ GF+ +C+++
Sbjct: 894 AFGRGCIDVNECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRCEDVNECEAQRCS 953
Query: 570 ANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR 629
C N+ G Y C CR GY + G +C DIDEC G C N+ G Y C
Sbjct: 954 QECANIYGSYQCYCRQGY----QLAEDGHTCTDIDECAQGAGILCTFR-CLNVPGSYQCA 1008
Query: 630 CP--------HGKNC---------TGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVM- 671
CP +G++C T +C + + HN + + RC C +V
Sbjct: 1009 CPEQGYTMTANGRSCKDVDECALGTHNC-SEAETCHN----IQGSFRCLRFECPPNYVQV 1063
Query: 672 ----CRRMVC----DCEN 681
C R C +C+N
Sbjct: 1064 SKTKCERTTCHDFLECQN 1081
Score = 80.9 bits (198), Expect = 4e-15
Identities = 93/398 (23%), Positives = 148/398 (37%), Gaps = 127/398 (31%)
Query: 482 EHDECITNQHNCDENALCFNTVGGHNCVCKPGYT--GNGTTCK----------------- 522
+ DEC+ ++ LC NTVG ++C C PG++ +G TC+
Sbjct: 604 DQDECLLLPGELCQH-LCINTVGSYHCACFPGFSLQDDGRTCRPEGHPPQPEAPQEPALK 662
Query: 523 -AFCK-------------DGCRNGGACI-------AANVCACPQGFT----GPSCETDID 557
F + + C++ G C + +C+C G+ G SCE DI+
Sbjct: 663 SEFSQVASNTIPLPLPQPNTCKDNGPCKQVCSTVGGSAICSCFPGYAIMADGVSCE-DIN 721
Query: 558 ECSDGFVQCDSRANCINLPGWYHC----ECRDGYHDNGMFSPSGESCEDIDECGTGRHSC 613
EC C +C+N G +HC C GY + CED+DEC G H+C
Sbjct: 722 ECVTDLHTCSRGEHCVNTLGSFHCYKALTCEPGY------ALKDGECEDVDECAMGTHTC 775
Query: 614 ANDTICFNLDGGYDC----RCPHG--KNCTGDCIHDGKVKHNGQIWVLENDRCSVCS--C 665
+C N G + C RC G ++ G+C+ + + C+ S C
Sbjct: 776 QPGFLCQNTKGSFYCQARQRCMDGFLQDPEGNCV--------------DINECTSLSEPC 821
Query: 666 QNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETL----YNSGDTWVQNC-- 719
+ GF C N TV + C + +P + ++ H + + N +T V C
Sbjct: 822 RPGF--------SCIN-TVGSYTC-QRNPLICARGYHASDDGTKCVDVNECETGVHRCGE 871
Query: 720 -QQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEMN 778
Q C L G C C+A R+ + C+D +N
Sbjct: 872 GQVCHNLPGSYRC---------------------------DCKAGFQRDAFGRGCID-VN 903
Query: 779 VVRFTGSSWIKHGTECTL----CQCKNGHICCSVDPQC 812
+ +H E TL C C +G + + +C
Sbjct: 904 ECWASPGRLCQHTCENTLGSYRCSCASGFLLAADGKRC 941
Score = 60.1 bits (144), Expect = 8e-09
Identities = 41/156 (26%), Positives = 63/156 (40%), Gaps = 16/156 (10%)
Query: 356 CVLYECKDQTMKLVESSGCPALDCPESHQITLS-HSCCKVCKGYDFCSERHNCMENSICR 414
C C + + S C C + +Q+ H+C + D C++ + C
Sbjct: 947 CEAQRCSQECANIYGSYQCY---CRQGYQLAEDGHTCTDI----DECAQGAGILCTFRCL 999
Query: 415 NLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCI---CKTG 471
N+ C+C + + + C+D+DECA G H C E C N GSF C+ C
Sbjct: 1000 NVPGSYQCACPEQGYTMTANGRSCKDVDECALGTHNCSEAETCHNIQGSFRCLRFECPPN 1059
Query: 472 YIRIDDYSC---TEHD--ECITNQHNCDENALCFNT 502
Y+++ C T HD EC + L F T
Sbjct: 1060 YVQVSKTKCERTTCHDFLECQNSPARITHYQLNFQT 1095
Score = 34.7 bits (78), Expect = 0.37
Identities = 30/110 (27%), Positives = 47/110 (42%), Gaps = 19/110 (17%)
Query: 639 DCIHDGKVKHN---GQIWVLENDRCSVCSCQNG-------FVMCRRMVCDCENPTVDLFC 688
DC+ G V+ GQ + ++ CSC G F++C + +C V
Sbjct: 72 DCLQGGFVRGRVPAGQSYFVDFGSTE-CSCPPGGGKISCQFMLCPELPPNCIEAVVVADS 130
Query: 689 CPECDPRLSSQCLHQNGETLYNSGDT-WVQNCQQCRC--LQGEVDCWPLP 735
CP+C C+H + Y +G T + C+ C C GE+ C+ LP
Sbjct: 131 CPQCG---QVGCVHAGHK--YAAGHTVHLPPCRACHCPDAGGELICYQLP 175
>gi|17978491 CD97 antigen isoform 1 precursor [Homo sapiens]
Length = 835
Score = 138 bits (347), Expect = 2e-32
Identities = 80/246 (32%), Positives = 109/246 (44%), Gaps = 54/246 (21%)
Query: 407 CMENSICRNLNDRAVCSCRDGFRALRE----DNAYCEDIDECAE-GRHYCRENTMCVNTP 461
C +NS C N C C GF + E C+DI+ECA + C + + C NT
Sbjct: 30 CPQNSSCVNAT---ACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFSDCWNTE 86
Query: 462 GSFMCICKTGYIRID---------DYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKP 512
GS+ C+C GY + + +C + DEC N C C NT+G + C C P
Sbjct: 87 GSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSYTCQCLP 146
Query: 513 GYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANC 572
G+ K +D P TD++EC+ G C S +C
Sbjct: 147 GF-------KFIPED----------------------PKVCTDVNECTSGQNPCHSSTHC 177
Query: 573 INLPGWYHCECRDGYHD-----NGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYD 627
+N G Y C CR G+ NG P+ CED+DEC +G+H C + T+CFN G Y
Sbjct: 178 LNNVGSYQCRCRPGWQPIPGSPNG---PNNTVCEDVDECSSGQHQCDSSTVCFNTVGSYS 234
Query: 628 CRCPHG 633
CRC G
Sbjct: 235 CRCRPG 240
Score = 110 bits (274), Expect = 7e-24
Identities = 70/245 (28%), Positives = 100/245 (40%), Gaps = 52/245 (21%)
Query: 370 ESSGCPALDCPESHQITLSHSC----------------CKVCKGYDFCS--ERHNCMENS 411
+S GC A CP++ + +C + C + C+ + +C + S
Sbjct: 22 DSRGC-ARWCPQNSSCVNATACRCNPGFSSFSEIITTPTETCDDINECATPSKVSCGKFS 80
Query: 412 ICRNLNDRAVCSCRDGFRAL-------REDNAYCEDIDECAEGRHYCRENTMCVNTPGSF 464
C N C C G+ + E C+D+DEC + C+ CVNT GS+
Sbjct: 81 DCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQDVDECQQNPRLCKSYGTCVNTLGSY 140
Query: 465 MCICKTGY--IRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCK 522
C C G+ I D CT+ +EC + Q+ C + C N VG + C C+PG+
Sbjct: 141 TCQCLPGFKFIPEDPKVCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQP------ 194
Query: 523 AFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCE 582
+ P G CE D+DECS G QCDS C N G Y C
Sbjct: 195 -----------------IPGSPNGPNNTVCE-DVDECSSGQHQCDSSTVCFNTVGSYSCR 236
Query: 583 CRDGY 587
CR G+
Sbjct: 237 CRPGW 241
Score = 32.0 bits (71), Expect = 2.4
Identities = 16/54 (29%), Positives = 26/54 (48%), Gaps = 6/54 (11%)
Query: 394 VCKGYDFCSE-RHNCMENSICRNLNDRAVCSCRDGFRAL-----REDNAYCEDI 441
VC+ D CS +H C +++C N C CR G++ + + CED+
Sbjct: 206 VCEDVDECSSGQHQCDSSTVCFNTVGSYSCRCRPGWKPRHGIPNNQKDTVCEDM 259
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 136 bits (342), Expect = 9e-32
Identities = 151/583 (25%), Positives = 207/583 (35%), Gaps = 131/583 (22%)
Query: 264 RLDQCYCERTCTMKGTTYREF--ESWIDGCKNCTCLNGTI--QCETLICPNPDCPLKSAL 319
R D+ Y TC +F D N C++G + +C+ +C C L
Sbjct: 197 RCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQ-GCNLLHGG 255
Query: 320 AYVDGKCCKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDC 379
V G EC+ +QGR E CV Y GC C
Sbjct: 256 CTVPG----ECRCSYGWQGRFCDE------------CVPYP------------GCVHGSC 287
Query: 380 PESHQITLSHSCCKVC--KGYDFCSERHNCMENSICRNLN-DRAVCSCRDGFRALREDNA 436
E Q + + K ++C H C C N D+ C+C DG+
Sbjct: 288 VEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINAEPDQYRCTCPDGYSG------ 341
Query: 437 YCEDIDECAEGRHYCRENT-----MCVNTPGSFMCICKTGYIRIDDYSCT-EHDECITNQ 490
C + H C N C P F C C +G+ +C + DEC +N
Sbjct: 342 -----RNCEKAEHACTSNPCANGGSCHEVPSGFECHCPSGW---SGPTCALDIDECASNP 393
Query: 491 HNCDENALCFNTVGGHNCVCKPGYTGNGTTCKA---FCKDGCRNGGAC---IAANVCACP 544
C C + V G C+C + G TC+ C+ C++GG C + C CP
Sbjct: 394 --CAAGGTCVDQVDGFECICPEQWV--GATCQLDVNDCRGQCQHGGTCKDLVNGYQCVCP 449
Query: 545 QGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE-DI 603
+GF G CE + DEC+ C S C +L +HC C G+ SG CE D+
Sbjct: 450 RGFGGRHCELERDECASS--PCHSGGLCEDLADGFHCHCPQGF--------SGPLCEVDV 499
Query: 604 DECGTGRHSCANDTICFNLDGGYDCRCPH---GKNCT--------GDC-IHD--GKVKHN 649
D C C N C+NL+G Y C CP GKNC+ G C + D G
Sbjct: 500 DLCEPS--PCRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGP 557
Query: 650 GQIWVLENDRCSV---CSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGE 706
G + C C Q G C C++ +C D L C +NG
Sbjct: 558 GMPGTAASGVCGPHGRCVSQPG----GNFSCICDSGFTGTYCHENIDDCLGQPC--RNGG 611
Query: 707 TLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQAD--- 763
T + D + +C C G W E E N+C P DPC +
Sbjct: 612 TCIDEVDAF-----RCFCPSG----W-------EGELCDTNPNDCLP----DPCHSRGRC 651
Query: 764 -TIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHIC 805
+ ND C D + G + +C C NG C
Sbjct: 652 YDLVNDFYCACDD-----GWKGKTCHSREFQCDAYTCSNGGTC 689
Score = 117 bits (292), Expect = 6e-26
Identities = 117/463 (25%), Positives = 166/463 (35%), Gaps = 131/463 (28%)
Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYCRENTMCVNTPGSFM 465
C +C +L D C C GF CE D+D C CR C N G +
Sbjct: 469 CHSGGLCEDLADGFHCHCPQGF-----SGPLCEVDVDLCEPSP--CRNGARCYNLEGDYY 521
Query: 466 CICKTGYIRIDDY---------------SCTEHDECITNQHN----------CDENALCF 500
C C DD+ +C D C ++ C + C
Sbjct: 522 CACP------DDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCV 575
Query: 501 NTVGGH-NCVCKPGYTGNGTTCKAFCKD----GCRNGGACIA---ANVCACPQGFTGPSC 552
+ GG+ +C+C G+TG T C D CRNGG CI A C CP G+ G C
Sbjct: 576 SQPGGNFSCICDSGFTG--TYCHENIDDCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELC 633
Query: 553 ETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFS----------PSGESCED 602
+T+ ++C C SR C +L ++C C DG+ S +G +C D
Sbjct: 634 DTNPNDCLPD--PCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYD 691
Query: 603 IDE--------------CGTGRHS------CANDTICFNLDGGYDCRCP---HGKNCT-- 637
+ C ++S C N C + C C G+ CT
Sbjct: 692 SGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHN 751
Query: 638 -GDC----IHDGKVKHNGQIWVLENDRCSVCSCQNGFVM--CRRMVCDCENP--TVDLFC 688
DC ++G + +G W C C GF CR + +C++ C
Sbjct: 752 TNDCNPLPCYNGGICVDGVNWFR-------CECAPGFAGPDCRINIDECQSSPCAYGATC 804
Query: 689 CPE-------CDP-RLSSQCLHQNG--------ETLYNSGDTWVQNCQQCRCLQGEVDCW 732
E C P R +C G T + G +WV++C CRCL G DC
Sbjct: 805 VDEINGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCS 864
Query: 733 PLPCPDVECEFSILPE--NECCP-----------RCVTDPCQA 762
+ C C + PE + CP +C+ PC+A
Sbjct: 865 KVWCGWKPCLLAGQPEALSAQCPLGQRCLEKAPGQCLRPPCEA 907
Score = 68.2 bits (165), Expect = 3e-11
Identities = 56/211 (26%), Positives = 81/211 (38%), Gaps = 31/211 (14%)
Query: 393 KVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCR 452
K C +F + + C C + D C+C G++ + C + + C
Sbjct: 669 KTCHSREFQCDAYTCSNGGTCYDSGDTFRCACPPGWK-----GSTCAVAKNSSCLPNPCV 723
Query: 453 ENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKP 512
CV + SF CIC+ G+ + +CT H+ N C +C + V C C P
Sbjct: 724 NGGTCVGSGASFSCICRDGW---EGRTCT-HNTNDCNPLPCYNGGICVDGVNWFRCECAP 779
Query: 513 GYTG-----NGTTCKAFCKDGCRNGGAC---IAANVCACPQGFTGPSCETDIDECSDGFV 564
G+ G N C++ C G C I C+CP G GP C+ I GF
Sbjct: 780 GFAGPDCRINIDECQS---SPCAYGATCVDEINGYRCSCPPGRAGPRCQEVI-----GFG 831
Query: 565 Q-CDSRANCI-NLPGWYH----CECRDGYHD 589
+ C SR + W C C DG D
Sbjct: 832 RSCWSRGTPFPHGSSWVEDCNSCRCLDGRRD 862
Score = 41.2 bits (95), Expect = 0.004
Identities = 16/55 (29%), Positives = 26/55 (47%)
Query: 272 RTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKC 326
R+C +GT + SW++ C +C CL+G C + C C L + +C
Sbjct: 832 RSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQC 886
>gi|34734064 fibulin 1 isoform B precursor [Homo sapiens]
Length = 601
Score = 135 bits (340), Expect = 2e-31
Identities = 119/387 (30%), Positives = 157/387 (40%), Gaps = 86/387 (22%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C+G C ++ CR+ D VCSC G++ L D CED++EC G H CR
Sbjct: 180 CRGGGPCKQQ--------CRDTGDEVVCSCFVGYQLL-SDGVSCEDVNECITGSHSCRLG 230
Query: 455 TMCVNTPGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
C+NT GSF C C TGY +D SC + DEC + HNC + +C NT+G C
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290
Query: 511 KPGYTGNGTTCKA-FCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
K CK+ F +D N CI DI+EC C
Sbjct: 291 K-------LQCKSGFIQDALGN---CI------------------DINECLSISAPCPIG 322
Query: 570 ANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDG 624
CIN G Y C+ C GYH N G C D+DEC C C N G
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLN----EEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378
Query: 625 GYDCRCPHGKNCTG---DCIHDGKV-KHNGQI--WVLENDRCS-VCSCQNGFVMCRRMVC 677
+ C C G G C+ + ++ G++ EN S +CSC GF +
Sbjct: 379 SFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRL------ 432
Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGE--VDCWPLP 735
+VD C + + SS C Q +Y S QC C +G D +
Sbjct: 433 -----SVDGRSCEDINECSSSPC-SQECANVYGS--------YQCYCRRGYQLSDVDGVT 478
Query: 736 CPDV-ECEFSILPE--NECCPRCVTDP 759
C D+ EC LP + C RC+ P
Sbjct: 479 CEDIDEC---ALPTGGHICSYRCINIP 502
Score = 135 bits (339), Expect = 2e-31
Identities = 119/411 (28%), Positives = 173/411 (42%), Gaps = 101/411 (24%)
Query: 268 CYCERTCTMKGTTYREFESWIDGCKNC----TCLN--GTIQCETLICPNPDCPLKSALAY 321
C+ G + + I G +C +C+N G+ +C+ D +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR------DSSCGTGYEL 254
Query: 322 VDGKCCK---ECKS---------ICQ-----FQGRTYFEGERNTVYSSSGVCV-LYECKD 363
+ CK EC+S ICQ F+ R + + + + G C+ + EC
Sbjct: 255 TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-- 312
Query: 364 QTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS 423
L S+ CP + H+C Y C +N V +
Sbjct: 313 ----LSISAPCP-----------IGHTCINTEGSY-------TCQKN----------VPN 340
Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS--CT 481
C G+ L E+ C D+DECA C + CVN+PGSF C CKTGY D S C
Sbjct: 341 CGRGYH-LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY-FDGISRMCV 398
Query: 482 EHDECITNQHN-CDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF-------CKDGCRN 531
+ +EC C C NT+G + C C G+ + +G +C+ C C N
Sbjct: 399 DVNECQRYPGRLCGHK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECAN 456
Query: 532 GGACIAANVCACPQGF-----TGPSCETDIDECS--DGFVQCDSRANCINLPGWYHCEC- 583
+ C C +G+ G +CE DIDEC+ G C R CIN+PG + C C
Sbjct: 457 ---VYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR--CINIPGSFQCSCP 510
Query: 584 RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC---RCP 631
GY +P+G +C+DIDEC TG H+C+ + CFN+ GG+ C CP
Sbjct: 511 SSGYR----LAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/135 (36%), Positives = 64/135 (47%), Gaps = 19/135 (14%)
Query: 524 FCKDGCRNGGACIA-------ANVCACPQGF----TGPSCETDIDECSDGFVQCDSRANC 572
+ D CR GG C VC+C G+ G SCE D++EC G C +C
Sbjct: 175 YLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLGESC 233
Query: 573 INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR--- 629
IN G + C+ RD G SC+DIDEC +G H+C D IC N G + CR
Sbjct: 234 INTVGSFRCQ-RDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
Query: 630 -CPHG--KNCTGDCI 641
C G ++ G+CI
Sbjct: 293 QCKSGFIQDALGNCI 307
>gi|34734068 fibulin 1 isoform A precursor [Homo sapiens]
Length = 566
Score = 135 bits (340), Expect = 2e-31
Identities = 119/387 (30%), Positives = 157/387 (40%), Gaps = 86/387 (22%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C+G C ++ CR+ D VCSC G++ L D CED++EC G H CR
Sbjct: 180 CRGGGPCKQQ--------CRDTGDEVVCSCFVGYQLL-SDGVSCEDVNECITGSHSCRLG 230
Query: 455 TMCVNTPGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
C+NT GSF C C TGY +D SC + DEC + HNC + +C NT+G C
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290
Query: 511 KPGYTGNGTTCKA-FCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
K CK+ F +D N CI DI+EC C
Sbjct: 291 K-------LQCKSGFIQDALGN---CI------------------DINECLSISAPCPIG 322
Query: 570 ANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDG 624
CIN G Y C+ C GYH N G C D+DEC C C N G
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLN----EEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378
Query: 625 GYDCRCPHGKNCTG---DCIHDGKV-KHNGQI--WVLENDRCS-VCSCQNGFVMCRRMVC 677
+ C C G G C+ + ++ G++ EN S +CSC GF +
Sbjct: 379 SFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRL------ 432
Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGE--VDCWPLP 735
+VD C + + SS C Q +Y S QC C +G D +
Sbjct: 433 -----SVDGRSCEDINECSSSPC-SQECANVYGS--------YQCYCRRGYQLSDVDGVT 478
Query: 736 CPDV-ECEFSILPE--NECCPRCVTDP 759
C D+ EC LP + C RC+ P
Sbjct: 479 CEDIDEC---ALPTGGHICSYRCINIP 502
Score = 135 bits (339), Expect = 2e-31
Identities = 119/411 (28%), Positives = 173/411 (42%), Gaps = 101/411 (24%)
Query: 268 CYCERTCTMKGTTYREFESWIDGCKNC----TCLN--GTIQCETLICPNPDCPLKSALAY 321
C+ G + + I G +C +C+N G+ +C+ D +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR------DSSCGTGYEL 254
Query: 322 VDGKCCK---ECKS---------ICQ-----FQGRTYFEGERNTVYSSSGVCV-LYECKD 363
+ CK EC+S ICQ F+ R + + + + G C+ + EC
Sbjct: 255 TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-- 312
Query: 364 QTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS 423
L S+ CP + H+C Y C +N V +
Sbjct: 313 ----LSISAPCP-----------IGHTCINTEGSY-------TCQKN----------VPN 340
Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS--CT 481
C G+ L E+ C D+DECA C + CVN+PGSF C CKTGY D S C
Sbjct: 341 CGRGYH-LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY-FDGISRMCV 398
Query: 482 EHDECITNQHN-CDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF-------CKDGCRN 531
+ +EC C C NT+G + C C G+ + +G +C+ C C N
Sbjct: 399 DVNECQRYPGRLCGHK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECAN 456
Query: 532 GGACIAANVCACPQGF-----TGPSCETDIDECS--DGFVQCDSRANCINLPGWYHCEC- 583
+ C C +G+ G +CE DIDEC+ G C R CIN+PG + C C
Sbjct: 457 ---VYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR--CINIPGSFQCSCP 510
Query: 584 RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC---RCP 631
GY +P+G +C+DIDEC TG H+C+ + CFN+ GG+ C CP
Sbjct: 511 SSGYR----LAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/135 (36%), Positives = 64/135 (47%), Gaps = 19/135 (14%)
Query: 524 FCKDGCRNGGACIA-------ANVCACPQGF----TGPSCETDIDECSDGFVQCDSRANC 572
+ D CR GG C VC+C G+ G SCE D++EC G C +C
Sbjct: 175 YLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLGESC 233
Query: 573 INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR--- 629
IN G + C+ RD G SC+DIDEC +G H+C D IC N G + CR
Sbjct: 234 INTVGSFRCQ-RDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
Query: 630 -CPHG--KNCTGDCI 641
C G ++ G+CI
Sbjct: 293 QCKSGFIQDALGNCI 307
>gi|34734066 fibulin 1 isoform D [Homo sapiens]
Length = 703
Score = 135 bits (340), Expect = 2e-31
Identities = 119/387 (30%), Positives = 157/387 (40%), Gaps = 86/387 (22%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C+G C ++ CR+ D VCSC G++ L D CED++EC G H CR
Sbjct: 180 CRGGGPCKQQ--------CRDTGDEVVCSCFVGYQLL-SDGVSCEDVNECITGSHSCRLG 230
Query: 455 TMCVNTPGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
C+NT GSF C C TGY +D SC + DEC + HNC + +C NT+G C
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290
Query: 511 KPGYTGNGTTCKA-FCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
K CK+ F +D N CI DI+EC C
Sbjct: 291 K-------LQCKSGFIQDALGN---CI------------------DINECLSISAPCPIG 322
Query: 570 ANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDG 624
CIN G Y C+ C GYH N G C D+DEC C C N G
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLN----EEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378
Query: 625 GYDCRCPHGKNCTG---DCIHDGKV-KHNGQI--WVLENDRCS-VCSCQNGFVMCRRMVC 677
+ C C G G C+ + ++ G++ EN S +CSC GF +
Sbjct: 379 SFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRL------ 432
Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGE--VDCWPLP 735
+VD C + + SS C Q +Y S QC C +G D +
Sbjct: 433 -----SVDGRSCEDINECSSSPC-SQECANVYGS--------YQCYCRRGYQLSDVDGVT 478
Query: 736 CPDV-ECEFSILPE--NECCPRCVTDP 759
C D+ EC LP + C RC+ P
Sbjct: 479 CEDIDEC---ALPTGGHICSYRCINIP 502
Score = 135 bits (339), Expect = 2e-31
Identities = 119/411 (28%), Positives = 173/411 (42%), Gaps = 101/411 (24%)
Query: 268 CYCERTCTMKGTTYREFESWIDGCKNC----TCLN--GTIQCETLICPNPDCPLKSALAY 321
C+ G + + I G +C +C+N G+ +C+ D +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR------DSSCGTGYEL 254
Query: 322 VDGKCCK---ECKS---------ICQ-----FQGRTYFEGERNTVYSSSGVCV-LYECKD 363
+ CK EC+S ICQ F+ R + + + + G C+ + EC
Sbjct: 255 TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-- 312
Query: 364 QTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS 423
L S+ CP + H+C Y C +N V +
Sbjct: 313 ----LSISAPCP-----------IGHTCINTEGSY-------TCQKN----------VPN 340
Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS--CT 481
C G+ L E+ C D+DECA C + CVN+PGSF C CKTGY D S C
Sbjct: 341 CGRGYH-LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY-FDGISRMCV 398
Query: 482 EHDECITNQHN-CDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF-------CKDGCRN 531
+ +EC C C NT+G + C C G+ + +G +C+ C C N
Sbjct: 399 DVNECQRYPGRLCGHK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECAN 456
Query: 532 GGACIAANVCACPQGF-----TGPSCETDIDECS--DGFVQCDSRANCINLPGWYHCEC- 583
+ C C +G+ G +CE DIDEC+ G C R CIN+PG + C C
Sbjct: 457 ---VYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR--CINIPGSFQCSCP 510
Query: 584 RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC---RCP 631
GY +P+G +C+DIDEC TG H+C+ + CFN+ GG+ C CP
Sbjct: 511 SSGYR----LAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/135 (36%), Positives = 64/135 (47%), Gaps = 19/135 (14%)
Query: 524 FCKDGCRNGGACIA-------ANVCACPQGF----TGPSCETDIDECSDGFVQCDSRANC 572
+ D CR GG C VC+C G+ G SCE D++EC G C +C
Sbjct: 175 YLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLGESC 233
Query: 573 INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR--- 629
IN G + C+ RD G SC+DIDEC +G H+C D IC N G + CR
Sbjct: 234 INTVGSFRCQ-RDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
Query: 630 -CPHG--KNCTGDCI 641
C G ++ G+CI
Sbjct: 293 QCKSGFIQDALGNCI 307
>gi|34734062 fibulin 1 isoform C precursor [Homo sapiens]
Length = 683
Score = 135 bits (340), Expect = 2e-31
Identities = 119/387 (30%), Positives = 157/387 (40%), Gaps = 86/387 (22%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C+G C ++ CR+ D VCSC G++ L D CED++EC G H CR
Sbjct: 180 CRGGGPCKQQ--------CRDTGDEVVCSCFVGYQLL-SDGVSCEDVNECITGSHSCRLG 230
Query: 455 TMCVNTPGSFMC----ICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
C+NT GSF C C TGY +D SC + DEC + HNC + +C NT+G C
Sbjct: 231 ESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRP 290
Query: 511 KPGYTGNGTTCKA-FCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSR 569
K CK+ F +D N CI DI+EC C
Sbjct: 291 K-------LQCKSGFIQDALGN---CI------------------DINECLSISAPCPIG 322
Query: 570 ANCINLPGWYHCE-----CRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDG 624
CIN G Y C+ C GYH N G C D+DEC C C N G
Sbjct: 323 HTCINTEGSYTCQKNVPNCGRGYHLN----EEGTRCVDVDECAPPAEPCGKGHRCVNSPG 378
Query: 625 GYDCRCPHGKNCTG---DCIHDGKV-KHNGQI--WVLENDRCS-VCSCQNGFVMCRRMVC 677
+ C C G G C+ + ++ G++ EN S +CSC GF +
Sbjct: 379 SFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRL------ 432
Query: 678 DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGE--VDCWPLP 735
+VD C + + SS C Q +Y S QC C +G D +
Sbjct: 433 -----SVDGRSCEDINECSSSPC-SQECANVYGS--------YQCYCRRGYQLSDVDGVT 478
Query: 736 CPDV-ECEFSILPE--NECCPRCVTDP 759
C D+ EC LP + C RC+ P
Sbjct: 479 CEDIDEC---ALPTGGHICSYRCINIP 502
Score = 135 bits (339), Expect = 2e-31
Identities = 119/411 (28%), Positives = 173/411 (42%), Gaps = 101/411 (24%)
Query: 268 CYCERTCTMKGTTYREFESWIDGCKNC----TCLN--GTIQCETLICPNPDCPLKSALAY 321
C+ G + + I G +C +C+N G+ +C+ D +
Sbjct: 201 CFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQR------DSSCGTGYEL 254
Query: 322 VDGKCCK---ECKS---------ICQ-----FQGRTYFEGERNTVYSSSGVCV-LYECKD 363
+ CK EC+S ICQ F+ R + + + + G C+ + EC
Sbjct: 255 TEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINEC-- 312
Query: 364 QTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCS 423
L S+ CP + H+C Y C +N V +
Sbjct: 313 ----LSISAPCP-----------IGHTCINTEGSY-------TCQKN----------VPN 340
Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS--CT 481
C G+ L E+ C D+DECA C + CVN+PGSF C CKTGY D S C
Sbjct: 341 CGRGYH-LNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYY-FDGISRMCV 398
Query: 482 EHDECITNQHN-CDENALCFNTVGGHNCVCKPGY--TGNGTTCKAF-------CKDGCRN 531
+ +EC C C NT+G + C C G+ + +G +C+ C C N
Sbjct: 399 DVNECQRYPGRLCGHK--CENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECAN 456
Query: 532 GGACIAANVCACPQGF-----TGPSCETDIDECS--DGFVQCDSRANCINLPGWYHCEC- 583
+ C C +G+ G +CE DIDEC+ G C R CIN+PG + C C
Sbjct: 457 ---VYGSYQCYCRRGYQLSDVDGVTCE-DIDECALPTGGHICSYR--CINIPGSFQCSCP 510
Query: 584 RDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC---RCP 631
GY +P+G +C+DIDEC TG H+C+ + CFN+ GG+ C CP
Sbjct: 511 SSGYR----LAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECP 557
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/135 (36%), Positives = 64/135 (47%), Gaps = 19/135 (14%)
Query: 524 FCKDGCRNGGACIA-------ANVCACPQGF----TGPSCETDIDECSDGFVQCDSRANC 572
+ D CR GG C VC+C G+ G SCE D++EC G C +C
Sbjct: 175 YLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCE-DVNECITGSHSCRLGESC 233
Query: 573 INLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCR--- 629
IN G + C+ RD G SC+DIDEC +G H+C D IC N G + CR
Sbjct: 234 INTVGSFRCQ-RDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKL 292
Query: 630 -CPHG--KNCTGDCI 641
C G ++ G+CI
Sbjct: 293 QCKSGFIQDALGNCI 307
>gi|209571521 cysteine rich BMP regulator 2 isoform 2 [Homo sapiens]
Length = 814
Score = 135 bits (339), Expect = 2e-31
Identities = 151/603 (25%), Positives = 202/603 (33%), Gaps = 108/603 (17%)
Query: 272 RTCTMKGTTYREFESWI-DGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKEC 330
R C+ G TY E++ D C C CL GTI C CP CP G CC C
Sbjct: 136 RGCSQNGQTYGNGETFSPDACTTCRCLEGTITCNQKPCPRGPCP-------EPGACCPHC 188
Query: 331 KSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHS 390
K C ++G+ Y EG T SSS C+ C ++ + CP CPE +
Sbjct: 189 KPGCDYEGQLYEEGV--TFLSSSNPCLQCTCLRSRVRCMALK-CPPSPCPEP--VLRPGH 243
Query: 391 CCKVCKGYDFCSERHNCMENS-----------ICRNLNDRAVCSCRD-----GFRALRED 434
CC C+G C+E + E+ ICR L C R+ + A
Sbjct: 244 CCPTCQG---CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPARPLP 300
Query: 435 NAYCEDIDEC-AEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCT----EHDECITN 489
C D C GR + + P S C C G ++ + C H I
Sbjct: 301 GTCCPVCDGCFLNGREHRSGEPVGSGDPCSH-CRCANGSVQCEPLPCPPVPCRHPGKIPG 359
Query: 490 QHNCDENALCFNTVGGHNCVCKPGYT--GNGTTCKAFCKDG---CRNGGACIAANVCACP 544
Q C C GH + + G + C+ G C + CA P
Sbjct: 360 QC-CPVCDGC--EYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTP--CALP 414
Query: 545 QGFTG--PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMF--------- 593
P+CE D +E ++G C C C+DG G
Sbjct: 415 ASGRQLCPACELDGEEFAEGVQWEPDGRPCTA------CVCQDGVPKCGAVLCPPAPCQH 468
Query: 594 --SPSGESCEDIDECGTGRHSCANDT----------ICFNLDGGYDCR---CPH------ 632
P G C D C AN C DG C CP
Sbjct: 469 PTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCARP 528
Query: 633 ----GKNCTG--DCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVCD---CENPT 683
G+ C DCI + +V +G+ + D C C CQ G C+ C C +P
Sbjct: 529 QSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAHPL 588
Query: 684 VDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEF 743
C +C + +G + D C+ CRCL G V C C + C
Sbjct: 589 PGTCCPNDCSGCAFGGKEYPSGADFPHPSDP----CRLCRCLSGNVQCLARRCVPLPCPE 644
Query: 744 SILPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGH 803
+L ECCP+C P A R E + G C C C +G
Sbjct: 645 PVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEY---------FSPPGDPCRRCLCLDGS 695
Query: 804 ICC 806
+ C
Sbjct: 696 VSC 698
Score = 110 bits (276), Expect = 4e-24
Identities = 142/577 (24%), Positives = 197/577 (34%), Gaps = 116/577 (20%)
Query: 274 CTMKGTTYREFESWI---DGCKNCTCLNGTIQCE----TLICPNPDCPLKSALAYVDGKC 326
CT G+ + + W D C+ C CL G IQC +CP P PL G C
Sbjct: 251 CTEGGSHWEHGQEWTTPGDPCRICRCLEGHIQCRQRECASLCPYPARPLP-------GTC 303
Query: 327 CKECKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQIT 386
C C C GR + GE S C C + +++ E CP + C H
Sbjct: 304 CPVCDG-CFLNGREHRSGEP---VGSGDPCSHCRCANGSVQC-EPLPCPPVPC--RHPGK 356
Query: 387 LSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNA---------- 436
+ CC VC G ++ ++ E + CSC+ G + E
Sbjct: 357 IPGQCCPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPAS 416
Query: 437 ------YCE-DIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITN 489
CE D +E AEG + + C C+C+ G + C C
Sbjct: 417 GRQLCPACELDGEEFAEGVQWEPDGRPCT------ACVCQDGVPKCGAVLCPPAP-C--- 466
Query: 490 QHNCDENALCFNTVGG---HNCVCKPG--YTGNGTTCKA-FCKDGCRNGGAC-IAANVCA 542
QH C + H+ V G +T + C A C+DG CA
Sbjct: 467 QHPTQPPGACCPSCDSCTYHSQVYANGQNFTDADSPCHACHCQDGTVTCSLVDCPPTTCA 526
Query: 543 CPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCED 602
PQ G C D + V D + C C++G+ C+
Sbjct: 527 RPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGH----------AHCQP 576
Query: 603 IDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSV 662
C L G C CP+ +C+G C GK +G + +D C +
Sbjct: 577 --------RPCPRAPCAHPLPG--TC-CPN--DCSG-CAFGGKEYPSGADFPHPSDPCRL 622
Query: 663 CSCQNGFVMCRRMVC---DCENPTV-DLFCCPECD--------PRL-SSQCLHQNGETLY 709
C C +G V C C C P + CCP+C PR ++ HQ E
Sbjct: 623 CRCLSGNVQCLARRCVPLPCPEPVLLPGECCPQCPAAPAPAGCPRPGAAHARHQ--EYFS 680
Query: 710 NSGDTWVQNCQQCRCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDI 769
GD C++C CL G V C LPCP C + CCP C
Sbjct: 681 PPGDP----CRRCLCLDGSVSCQRLPCPPAPCAHP--RQGPCCPSC-------------- 720
Query: 770 TKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICC 806
CL + +G + C LC C G + C
Sbjct: 721 -DGCLYQGKEFA-SGERFPSPTAACHLCLCWEGSVSC 755
Score = 92.4 bits (228), Expect = 1e-18
Identities = 88/321 (27%), Positives = 114/321 (35%), Gaps = 58/321 (18%)
Query: 508 CVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCD 567
CVC+ G G GC G + F+ +C T C +G + C+
Sbjct: 117 CVCQDGAAHCGPQAHLPHCRGCSQNGQTYGNG-----ETFSPDACTTC--RCLEGTITCN 169
Query: 568 S----RANCINLPGWYHCECRDG-------YHDNGMFSPSGESCEDIDECGTGRHSC--- 613
R C PG C+ G Y + F S C C R C
Sbjct: 170 QKPCPRGPCPE-PGACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCT-CLRSRVRCMAL 227
Query: 614 -ANDTICFN--LDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFV 670
+ C L G+ C C G C G +GQ W D C +C C G +
Sbjct: 228 KCPPSPCPEPVLRPGHCC-----PTCQG-CTEGGSHWEHGQEWTTPGDPCRICRCLEGHI 281
Query: 671 MCRRMVCD--CENPTVDL--FCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQ 726
CR+ C C P L CCP CD + H++GE + SGD C CRC
Sbjct: 282 QCRQRECASLCPYPARPLPGTCCPVCDGCFLNGREHRSGEPV-GSGDP----CSHCRCAN 336
Query: 727 GEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRNDITKTC-LDEMNVVRFTGS 785
G V C PLPCP V C +CCP C D C+ + +T L E +
Sbjct: 337 GSVQCEPLPCPPVPCRHPGKIPGQCCPVC--DGCEYQGHQYQSQETFRLQERGL------ 388
Query: 786 SWIKHGTECTLCQCKNGHICC 806
C C C+ G + C
Sbjct: 389 --------CVRCSCQAGEVSC 401
Score = 89.7 bits (221), Expect = 1e-17
Identities = 137/602 (22%), Positives = 186/602 (30%), Gaps = 164/602 (27%)
Query: 234 FHGLVQKIMELQDILAKTSAKLSRAEQRMNRLDQCYCERT---CTMKGTTYREFESWI-D 289
+H L + + L+ + + + + R+ +L+ C C C G + E W D
Sbjct: 53 WHPLREWLGRLEAAVMELREQNKDLQTRVRQLESCECHPASPQCWGLGRAWPEGARWEPD 112
Query: 290 GCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECKSICQFQGRTYFEGERNTV 349
C C C +G C P P C+ C G+TY GE
Sbjct: 113 ACTACVCQDGAAHCG----PQAHLP--------------HCRG-CSQNGQTYGNGET--- 150
Query: 350 YSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCK-GYDFCSERHNCM 408
S C C + T+ + CP CPE +CC CK G D+
Sbjct: 151 -FSPDACTTCRCLEGTITCNQKP-CPRGPCPEPG------ACCPHCKPGCDY-------- 194
Query: 409 ENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCIC 468
EG+ Y T ++ C C
Sbjct: 195 -------------------------------------EGQLYEEGVTFLSSSNPCLQCTC 217
Query: 469 KTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDG 528
+R C C E L +PG+ C C+ G
Sbjct: 218 LRSRVRCMALKCPPSP--------CPEPVL------------RPGH------CCPTCQ-G 250
Query: 529 CRNGGACIAANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINL--------PGWYH 580
C GG+ Q +T P I C +G +QC R C +L PG
Sbjct: 251 CTEGGSHWEHG-----QEWTTPGDPCRICRCLEGHIQCRQR-ECASLCPYPARPLPGTC- 303
Query: 581 CECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDC 640
C DG NG SGE D C R CAN ++ C H G C
Sbjct: 304 CPVCDGCFLNGREHRSGEPVGSGDPCSHCR--CANGSVQCEPLPCPPVPCRHPGKIPGQC 361
Query: 641 --IHDGKVKHNGQIWVLENDR------CSVCSCQNGFVMCRRMVCD---CENPTVDLFCC 689
+ DG Q E R C CSCQ G V C C C P C
Sbjct: 362 CPVCDGCEYQGHQYQSQETFRLQERGLCVRCSCQAGEVSCEEQECPVTPCALPASGRQLC 421
Query: 690 PECDPRLSSQCLHQNGETLYNSGDTWVQN---CQQCRCLQGEVDCWPLPCPDVECEFSIL 746
P C+ +GE + G W + C C C G C + CP C+
Sbjct: 422 PACE---------LDGEE-FAEGVQWEPDGRPCTACVCQDGVPKCGAVLCPPAPCQHPTQ 471
Query: 747 PENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHICC 806
P CCP C D C + V G ++ + C C C++G + C
Sbjct: 472 PPGACCPSC--DSCTYHS--------------QVYANGQNFTDADSPCHACHCQDGTVTC 515
Query: 807 SV 808
S+
Sbjct: 516 SL 517
Score = 86.3 bits (212), Expect = 1e-16
Identities = 117/506 (23%), Positives = 163/506 (32%), Gaps = 123/506 (24%)
Query: 274 CTMKGTTYREFESWIDG--CKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKECK 331
C + G +R E G C +C C NG++QCE L CP C + G+CC C
Sbjct: 310 CFLNGREHRSGEPVGSGDPCSHCRCANGSVQCEPLPCPPVPCRHPGK---IPGQCCPVCD 366
Query: 332 SICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDC--PESHQITLSH 389
C++QG Y + + G+CV C+ + E CP C P S
Sbjct: 367 G-CEYQGHQY-QSQETFRLQERGLCVRCSCQAGEVSCEEQE-CPVTPCALPAS-----GR 418
Query: 390 SCCKVCK--GYDFCSERHNCMENSICRNLNDRAVCSCRDGF--------------RALRE 433
C C+ G +F + C C C+DG +
Sbjct: 419 QLCPACELDGEEFAEGVQWEPDGRPC------TACVCQDGVPKCGAVLCPPAPCQHPTQP 472
Query: 434 DNAYCEDIDEC-------AEGRHYCRENTMCVNTPGSFMCICKTGYIRID---------- 476
A C D C A G+++ ++ C C C+ G +
Sbjct: 473 PGACCPSCDSCTYHSQVYANGQNFTDADSPC------HACHCQDGTVTCSLVDCPPTTCA 526
Query: 477 ------DYSCTEHDECITNQ----------HNCDENALCFNTVGGHNCVCKP------GY 514
C +CI + H D C G +C +P +
Sbjct: 527 RPQSGPGQCCPRCPDCILEEEVFVDGESFSHPRDPCQECRCQEGHAHCQPRPCPRAPCAH 586
Query: 515 TGNGTTCKAFCKDGCRNGGACIAANVCACPQG--FTGPSCETDIDECSDGFVQCDSRANC 572
GT C C GC GG P G F PS + C G VQC +R C
Sbjct: 587 PLPGTCCPNDCS-GCAFGGK-------EYPSGADFPHPSDPCRLCRCLSGNVQCLAR-RC 637
Query: 573 INLP--------GWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDG 624
+ LP G +C G P + C C LDG
Sbjct: 638 VPLPCPEPVLLPGECCPQCPAAPAPAGCPRPGAAHARHQEYFSPPGDPCRR---CLCLDG 694
Query: 625 GYDCR--------CPHGK------NCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFV 670
C+ C H + +C G C++ GK +G+ + C +C C G V
Sbjct: 695 SVSCQRLPCPPAPCAHPRQGPCCPSCDG-CLYQGKEFASGERFPSPTAACHLCLCWEGSV 753
Query: 671 MCRRMVCD---CENPTVDLFCCPECD 693
C C C P CCP+CD
Sbjct: 754 SCEPKACAPALCPFPARG-DCCPDCD 778
Score = 77.0 bits (188), Expect = 6e-14
Identities = 68/261 (26%), Positives = 97/261 (37%), Gaps = 43/261 (16%)
Query: 559 CSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTI 618
C DG C +A+ LP HC G NG +GE+ D C T R C TI
Sbjct: 119 CQDGAAHCGPQAH---LP---HCR---GCSQNGQTYGNGETFSP-DACTTCR--CLEGTI 166
Query: 619 CFNLDGGYDCRCPHG----KNCTGDCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRR 674
N CP +C C ++G++ G ++ ++ C C+C V C
Sbjct: 167 TCNQKPCPRGPCPEPGACCPHCKPGCDYEGQLYEEGVTFLSSSNPCLQCTCLRSRVRCMA 226
Query: 675 MVCD---CENPTVDL-FCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVD 730
+ C C P + CCP C ++G+ GD C+ CRCL+G +
Sbjct: 227 LKCPPSPCPEPVLRPGHCCPTCQGCTEGGSHWEHGQEWTTPGDP----CRICRCLEGHIQ 282
Query: 731 CWPLPCPDVECEFSILP-ENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIK 789
C C + C + P CCP C D C +N +
Sbjct: 283 CRQRECASL-CPYPARPLPGTCCPVC--DGCF---------------LNGREHRSGEPVG 324
Query: 790 HGTECTLCQCKNGHICCSVDP 810
G C+ C+C NG + C P
Sbjct: 325 SGDPCSHCRCANGSVQCEPLP 345
Score = 63.5 bits (153), Expect = 7e-10
Identities = 48/176 (27%), Positives = 68/176 (38%), Gaps = 39/176 (22%)
Query: 274 CTMKGTTYREFESWI----DGCKNCTCLNGTIQCETLICPNPDCPLKSALAYVDGKCCKE 329
C G + + + D C+ C CL+G++ C+ L CP C G CC
Sbjct: 665 CPRPGAAHARHQEYFSPPGDPCRRCLCLDGSVSCQRLPCPPAPCAHPR-----QGPCCPS 719
Query: 330 CKSICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSH 389
C C +QG+ + GER S + C L C + ++ + PAL CP
Sbjct: 720 CDG-CLYQGKEFASGER--FPSPTAACHLCLCWEGSVSCEPKACAPAL-CP----FPARG 771
Query: 390 SCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALR---EDNAYCEDID 442
CC C G E H + SCR G R R ++N YC +D
Sbjct: 772 DCCPDCDG-----EGH--------------GIGSCRGGMRETRGLGQNNLYCPRVD 808
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 134 bits (338), Expect = 3e-31
Identities = 140/524 (26%), Positives = 201/524 (38%), Gaps = 114/524 (21%)
Query: 288 IDGCKNCTCLNGTIQC----ETLICPNPDCPLKSALAYVDGKCCKECKSICQ------FQ 337
ID C+ C NG QC C P+ +GK C K C+
Sbjct: 526 IDYCEPNPCQNGA-QCYNRASDYFCKCPED--------YEGKNCSHLKDHCRTTPCEVID 576
Query: 338 GRTYFEGERNTV----YSSSGVCVLY-ECKDQTMKLVESSGCPALDCPESHQITLSHSCC 392
T +T Y SS VC + +CK Q S G DC + T H
Sbjct: 577 SCTVAMASNDTPEGVRYISSNVCGPHGKCKSQ------SGGKFTCDCNKGFTGTYCHENI 630
Query: 393 KVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCE-DIDECAEGRHYC 451
C E + C C + + C C DG+ + AYCE +I++C++ C
Sbjct: 631 NDC-------ESNPCRNGGTCIDGVNSYKCICSDGW-----EGAYCETNINDCSQNP--C 676
Query: 452 RENTMCVNTPGSFMCICKTGYIRIDDYSCTEHD-ECITNQHNCDENALCFNTVGGHNCVC 510
C + F C CK G+ +C D +C ++ C+ C++ C+C
Sbjct: 677 HNGGTCRDLVNDFYCDCKNGW---KGKTCHSRDSQC--DEATCNNGGTCYDEGDAFKCMC 731
Query: 511 KPGYTGNGTTCK-----AFCKDGCRNGGACIAAN---VCACPQGFTGPSCETDIDECSDG 562
G+ GTTC + + C NGG C+ C C +G+ GP C + ++CS
Sbjct: 732 PGGW--EGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPH 789
Query: 563 FVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE-DIDECGTGRHSCANDTICFN 621
C + C++ WY CEC G+ +G C +I+EC + CA C +
Sbjct: 790 --PCYNSGTCVDGDNWYRCECAPGF--------AGPDCRININECQSS--PCAFGATCVD 837
Query: 622 LDGGYDCRCPHG------KNCTG-DCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRR 674
GY C CP G + +G CI G V +G W +D C+ C C NG + C +
Sbjct: 838 EINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKW---DDDCNTCQCLNGRIACSK 894
Query: 675 MVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRCLQGEVDCWPL 734
+ C PR CL G + SG Q C + + C+
Sbjct: 895 V---------------WCGPR---PCLLHKGHSECPSG-------QSCIPILDD-QCFVH 928
Query: 735 PCPDV-ECEFSILPENECCPRCVTDPCQADTIRNDITKTCLDEM 777
PC V EC S L + +C +D D N IT T EM
Sbjct: 929 PCTGVGECRSSSLQPVK--TKCTSDSYYQDNCAN-ITFTFNKEM 969
Score = 112 bits (280), Expect = 1e-24
Identities = 113/448 (25%), Positives = 163/448 (36%), Gaps = 97/448 (21%)
Query: 407 CMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMC 466
C+ C+N +R C C GF N DID C C+ C N + C
Sbjct: 496 CLNGGHCQNEINRFQCLCPTGFSG----NLCQLDIDYCEPNP--CQNGAQCYNRASDYFC 549
Query: 467 ICKTGY-----IRIDDYS----CTEHDECIT--------------NQHNCDENALCFNTV 503
C Y + D+ C D C + + C + C +
Sbjct: 550 KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQS 609
Query: 504 GGH-NCVCKPGYTGNGTTCKAFCKD----GCRNGGACIA---ANVCACPQGFTGPSCETD 555
GG C C G+TG T C D CRNGG CI + C C G+ G CET+
Sbjct: 610 GGKFTCDCNKGFTG--TYCHENINDCESNPCRNGGTCIDGVNSYKCICSDGWEGAYCETN 667
Query: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDID-ECGTGRHSCA 614
I++CS C + C +L ++C+C++G+ G++C D +C +C
Sbjct: 668 INDCSQN--PCHNGGTCRDLVNDFYCDCKNGW--------KGKTCHSRDSQCDEA--TCN 715
Query: 615 NDTICFNLDGGYDCRCP---HGKNC----TGDCIHDGKVKHNGQIWVLENDRCSVCSCQN 667
N C++ + C CP G C C+ + HNG V+ N C C+
Sbjct: 716 NGGTCYDEGDAFKCMCPGGWEGTTCNIARNSSCLPN--PCHNGGTCVV-NGESFTCVCKE 772
Query: 668 GF--VMCRRMVCDCE-NPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNCQQCRC 724
G+ +C + DC +P + C + GD W +C C
Sbjct: 773 GWEGPICAQNTNDCSPHPCYNSGTCVD--------------------GDNW----YRCEC 808
Query: 725 LQGEV--DCW--PLPCPDVECEFSILPENECCP-RCVTDPCQADTIRNDITKTCLDEMNV 779
G DC C C F +E RCV P + +++ M
Sbjct: 809 APGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVSGRPCITMGS 868
Query: 780 VRFTGSSWIKHGTECTLCQCKNGHICCS 807
V G+ W +C CQC NG I CS
Sbjct: 869 VIPDGAKW---DDDCNTCQCLNGRIACS 893
Score = 90.9 bits (224), Expect = 4e-18
Identities = 104/394 (26%), Positives = 148/394 (37%), Gaps = 129/394 (32%)
Query: 391 CCKVCK------GYDFCSERHN--CMENSI---CRNLNDRAVCSCRDGFRALREDNAYCE 439
C K C+ G+ C + N CME + C R CS + G L D C
Sbjct: 196 CNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGD---CR 252
Query: 440 DIDECAEGRH--YCRENTMCVNTPGS--------FMCICKT---GYIRIDDYS-CTEHDE 485
C G YC + C+ PG + C+C+T G + D + C H
Sbjct: 253 ----CQYGWQGLYCDK---CIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQP 305
Query: 486 CITNQHNCDENALCFNT-VGGHNCVCKPGYTG-NGTTCKAFC-KDGCRNGGACIAANV-- 540
C+ C NT + C C GY+G N + C D C N G+C ++
Sbjct: 306 CLNG-------GTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGF 358
Query: 541 -CACPQGFTGPSCETDIDECS--------------DGF---------------------- 563
C C G+TGP+C T+ID+CS +GF
Sbjct: 359 ECECSPGWTGPTCSTNIDDCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEA 418
Query: 564 VQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE-DIDECGTGRHSCANDTICFNL 622
C + +C NL Y+C+C G+ G++C+ +I++C C ND C +L
Sbjct: 419 KPCVNAKSCKNLIASYYCDCLPGW--------MGQNCDININDC---LGQCQNDASCRDL 467
Query: 623 DGGYDCRCP---HGKNCTGD--------CIHDGKVKH-------------NGQIWVLEND 658
GY C CP G +C D C++ G ++ +G + L+ D
Sbjct: 468 VNGYRCICPPGYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDID 527
Query: 659 RCSVCSCQNGFVMCRRMVCDCENPTVDLFC-CPE 691
C CQNG C N D FC CPE
Sbjct: 528 YCEPNPCQNG--------AQCYNRASDYFCKCPE 553
Score = 40.0 bits (92), Expect = 0.009
Identities = 21/65 (32%), Positives = 29/65 (44%), Gaps = 10/65 (15%)
Query: 272 RTCTMKGTTYREFESWIDGCKNCTCLNGTIQCETLIC-PNP--------DCPL-KSALAY 321
R C G+ + W D C C CLNG I C + C P P +CP +S +
Sbjct: 861 RPCITMGSVIPDGAKWDDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPI 920
Query: 322 VDGKC 326
+D +C
Sbjct: 921 LDDQC 925
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 130 bits (328), Expect = 4e-30
Identities = 129/442 (29%), Positives = 170/442 (38%), Gaps = 62/442 (14%)
Query: 333 ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCC 392
IC ++G + E +R V V + C + E S CP + + C
Sbjct: 900 IC-YEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCI--CPAGFMASEEGTNC 956
Query: 393 ---KVCKGYDFCSERHNCMENSICRNLNDRAVCS-CRDGFRALREDNAYCEDIDECAEGR 448
C D C E H C N C C G+R + CEDIDEC
Sbjct: 957 IDVDECLRPDVCGEGH-------CVNTVGAFRCEYCDSGYRMTQRGR--CEDIDECLNPS 1007
Query: 449 HYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC 508
E CVN+PGS+ C+ T R + C + DEC+ + N N C N G + C
Sbjct: 1008 TCPDEQ--CVNSPGSYQCVPCTEGFRGWNGQCLDVDECL--EPNVCANGDCSNLEGSYMC 1063
Query: 509 VCKPGYTGNGTTCKAFCK--DGCRNGGACIAANV--------CACPQGF----TGPSCET 554
C GYT T C+ D C+ G C+ C C QG+ CE
Sbjct: 1064 SCHKGYT--RTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCE- 1120
Query: 555 DIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCA 614
DIDEC + C + C N G + C C GY +G+ G+ CEDI+EC + C
Sbjct: 1121 DIDECQHRHL-C-AHGQCRNTEGSFQCVCDQGYRASGL----GDHCEDINECLEDKSVCQ 1174
Query: 615 NDTICFNLDGGYDCRCPHG------KNC--TGDCIHDGKVKHNGQIWVLENDRCSVCSCQ 666
C N G YDC CP G K C +C H G G+ L + C CQ
Sbjct: 1175 RGD-CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGE--CLNTEGSFHCVCQ 1231
Query: 667 NGF-VMCRRMVCDCENPTVDLFCCPE---CDPRLSS-QCLHQNGETLYNSGDTWVQNCQQ 721
GF + C+ + V+ C CD S +CL G G V + +
Sbjct: 1232 QGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCV-DVNE 1290
Query: 722 CRCLQGEVDCWPLPCPDVECEF 743
C L G C C +VE F
Sbjct: 1291 CELLSGV--CGEAFCENVEGSF 1310
Score = 130 bits (327), Expect = 5e-30
Identities = 113/384 (29%), Positives = 155/384 (40%), Gaps = 92/384 (23%)
Query: 399 DFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCV 458
D C H C NL R C C +G+R E C DIDEC + +H C + C
Sbjct: 883 DICGAGH-------CINLPVRYTCICYEGYR-FSEQQRKCVDIDECTQVQHLCSQG-RCE 933
Query: 459 NTPGSFMCICKTGYIRIDD-YSCTEHDECITNQHNCDENALCFNTVGGHNC-VCKPGYTG 516
NT GSF+CIC G++ ++ +C + DEC+ C E C NTVG C C GY
Sbjct: 934 NTEGSFLCICPAGFMASEEGTNCIDVDECL-RPDVCGEGH-CVNTVGAFRCEYCDSGYRM 991
Query: 517 -------------NGTTCK-------------AFCKDG-------CRNGGACIAANVCA- 542
N +TC C +G C + C+ NVCA
Sbjct: 992 TQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCAN 1051
Query: 543 -------------CPQGFTGPSCE---TDIDECSDGFVQCDSRANCINLPGWYHCECRDG 586
C +G+T DIDEC G + + + C N G + C C G
Sbjct: 1052 GDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQ--CKNTEGSFRCTCGQG 1109
Query: 587 YHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTG-------- 638
Y S + + CEDIDEC RH CA+ C N +G + C C G +G
Sbjct: 1110 Y----QLSAAKDQCEDIDEC-QHRHLCAHGQ-CRNTEGSFQCVCDQGYRASGLGDHCEDI 1163
Query: 639 -DCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC----DCENPTVDLFCCP--E 691
+C+ D V G + C+C +GF + C +CE+P + C P E
Sbjct: 1164 NECLEDKSVCQRGD--CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGL---CGPQGE 1218
Query: 692 C-DPRLSSQCLHQNGETLYNSGDT 714
C + S C+ Q G ++ G T
Sbjct: 1219 CLNTEGSFHCVCQQGFSISADGRT 1242
Score = 102 bits (253), Expect = 2e-21
Identities = 109/410 (26%), Positives = 155/410 (37%), Gaps = 107/410 (26%)
Query: 284 FESWIDGCKNCTCLNGTIQCETLICPNPDCP-------LKSALAYVDGKCCKECKSI--C 334
F W N CL+ E +C N DC Y K C+ I C
Sbjct: 1030 FRGW-----NGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDEC 1084
Query: 335 QFQGRTYFEGE-RNTVYSSSGVC----VLYECKDQTMKLVESSGCPALDCPESHQITLSH 389
Q QG G+ +NT S C L KDQ + E H+ +H
Sbjct: 1085 Q-QGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ----------HRHLCAH 1133
Query: 390 SCCK--------VC-KGY------DFCSERHNCMEN-SICR-----NLNDRAVCSCRDGF 428
C+ VC +GY D C + + C+E+ S+C+ N C+C DGF
Sbjct: 1134 GQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGF 1193
Query: 429 RALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECI 487
+ +DN C+DI+EC E C C+NT GSF C+C+ G+ I D +C + DEC+
Sbjct: 1194 QL--DDNKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECV 1250
Query: 488 TNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGF 547
N CD + C NT G C+C G+ ++G C+ N C G
Sbjct: 1251 NNT-VCDSHGFCDNTAGSFRCLCYQGF------------QAPQDGQGCVDVNECELLSGV 1297
Query: 548 TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE------ 601
G A C N+ G + C C D +N +SP C
Sbjct: 1298 CG-------------------EAFCENVEGSFLCVCAD---ENQEYSPMTGQCRSRTSTD 1335
Query: 602 ---DIDECGTGRHSC---AND-TICFNLDG----GYDCRCPHGKNCTGDC 640
D+D+ + C ND ++C N+ +C C G +C
Sbjct: 1336 LDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNC 1385
Score = 96.3 bits (238), Expect = 1e-19
Identities = 103/361 (28%), Positives = 135/361 (37%), Gaps = 56/361 (15%)
Query: 440 DIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENAL 498
+I+EC C C+N P + CIC GY C + DEC QH C +
Sbjct: 874 EINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGR- 931
Query: 499 CFNTVGGHNCVCKPGYTGN--GTTC--------KAFCKDG-CRNGGACIAANVCACPQGF 547
C NT G C+C G+ + GT C C +G C N C
Sbjct: 932 CENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM 991
Query: 548 TGPSCETDIDECSDGFVQCDSRANCINLPGWYHC-ECRDGYHD-NGMFSPSGESCEDIDE 605
T DIDEC + D + C+N PG Y C C +G+ NG C D+DE
Sbjct: 992 TQRGRCEDIDECLNPSTCPDEQ--CVNSPGSYQCVPCTEGFRGWNG-------QCLDVDE 1042
Query: 606 CGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS---- 661
C + CAN C NL+G Y C C G T D H + Q + N +C
Sbjct: 1043 C-LEPNVCANGD-CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEG 1100
Query: 662 --VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNC 719
C+C G+ + CE+ EC R C H G+ G
Sbjct: 1101 SFRCTCGQGYQLSAAK-DQCED-------IDECQHR--HLCAH--GQCRNTEGSF----- 1143
Query: 720 QQCRCLQG-EVDCWPLPCPDV-EC--EFSILPENECCPRCVTDPCQA-DTIRNDITKTCL 774
QC C QG C D+ EC + S+ +C + C D + D KTC
Sbjct: 1144 -QCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQ 1202
Query: 775 D 775
D
Sbjct: 1203 D 1203
Score = 90.9 bits (224), Expect = 4e-18
Identities = 104/424 (24%), Positives = 142/424 (33%), Gaps = 106/424 (25%)
Query: 289 DGCKNCTCLNG------TIQCETLICPNPDCPLKSALAYVDGKCCK---ECKSICQFQGR 339
+G CTC G QCE + +C + A+ G+C + +C R
Sbjct: 1099 EGSFRCTCGQGYQLSAAKDQCEDI----DECQHRHLCAH--GQCRNTEGSFQCVCDQGYR 1152
Query: 340 TYFEGER----NTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVC 395
G+ N VC +C + ++G CP+ Q+ + K C
Sbjct: 1153 ASGLGDHCEDINECLEDKSVCQRGDC-------INTAGSYDCTCPDGFQLDDN----KTC 1201
Query: 396 KGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENT 455
+ + C C C N C C+ GF ++ D CEDIDEC C +
Sbjct: 1202 QDINECEHPGLCGPQGECLNTEGSFHCVCQQGF-SISADGRTCEDIDECVNNT-VCDSHG 1259
Query: 456 MCVNTPGSFMCICKTGYIRIDD-YSCTEHDECITNQHNCDENALCFNTVGGHNCVC---K 511
C NT GSF C+C G+ D C + +EC C E A C N G CVC
Sbjct: 1260 FCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGE-AFCENVEGSFLCVCADEN 1318
Query: 512 PGYTGNGTTC------------------KAFCKDGCRNGGAC---IAANV----CACPQG 546
Y+ C K C + C +A NV C C G
Sbjct: 1319 QEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSG 1378
Query: 547 FT-GPSCET-------------------------------------DIDECSDGFVQCDS 568
G +CE D DEC +
Sbjct: 1379 AGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICK 1438
Query: 569 RANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
C+N Y C C+ G + + P C D+DEC SC D C N +G Y+C
Sbjct: 1439 NGFCLNTRPGYECYCKQGTY----YDPVKLQCFDMDEC-QDPSSCI-DGQCVNTEGSYNC 1492
Query: 629 RCPH 632
C H
Sbjct: 1493 FCTH 1496
Score = 68.6 bits (166), Expect = 2e-11
Identities = 73/287 (25%), Positives = 106/287 (36%), Gaps = 60/287 (20%)
Query: 550 PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTG 609
P+ T+I+EC+ C + +CINLP Y C C +GY FS C DIDEC
Sbjct: 869 PTQVTEINECTVNPDICGA-GHCINLPVRYTCICYEGYR----FSEQQRKCVDIDECTQV 923
Query: 610 RHSCANDTICFNLDGGYDCRCP-------HGKNC--TGDCIHDGKVKHNGQIWVLENDRC 660
+H C+ C N +G + C CP G NC +C+ + + RC
Sbjct: 924 QHLCSQGR-CENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRC 982
Query: 661 SVCSCQNGFVMCRRMVC----DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWV 716
C +G+ M +R C +C NP+ CP+ QC++ G
Sbjct: 983 EY--CDSGYRMTQRGRCEDIDECLNPST----CPD------EQCVNSPGS---------- 1020
Query: 717 QNCQQC---------RCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRN 767
C C +CL + P C + +C S L + C C R
Sbjct: 1021 YQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDC--SNLEGSYMC------SCHKGYTRT 1072
Query: 768 DITKTC--LDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDPQC 812
K C +DE + K+ C C G+ + QC
Sbjct: 1073 PDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQC 1119
Score = 56.2 bits (134), Expect = 1e-07
Identities = 61/268 (22%), Positives = 84/268 (31%), Gaps = 52/268 (19%)
Query: 409 ENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCIC 468
+N C N C C+ G C D+DEC + C + CVNT GS+ C C
Sbjct: 1438 KNGFCLNTRPGYECYCKQG-TYYDPVKLQCFDMDECQDPSS-CIDG-QCVNTEGSYNCFC 1494
Query: 469 KTGYIR-IDDYSCTEHDECITNQHNCDE-NALCFNTVGGHNCVCKPGYTGNGTTCKAFCK 526
+ + C E D LC+ + +P T + C
Sbjct: 1495 THPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCL 1554
Query: 527 DGCRNGGACIA---------ANVCACP------------------------------QGF 547
G G C A +C P F
Sbjct: 1555 YGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRF 1614
Query: 548 TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECG 607
E +EC G + C+ + Y C+C DGYH + +C D++EC
Sbjct: 1615 LNSFEELQAEEC--GILNGCENGRCVRVQEGYTCDCFDGYH----LDTAKMTCVDVNECD 1668
Query: 608 --TGRHSCANDTICFNLDGGYDCRCPHG 633
R S + C N DG Y C C G
Sbjct: 1669 ELNNRMSLCKNAKCINTDGSYKCLCLPG 1696
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 4/92 (4%)
Query: 406 NCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAE--GRHYCRENTMCVNTPGS 463
N EN C + + C C DG+ L C D++EC E R +N C+NT GS
Sbjct: 1630 NGCENGRCVRVQEGYTCDCFDGYH-LDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGS 1688
Query: 464 FMCICKTGYIRIDDYS-CTEHDECITNQHNCD 494
+ C+C GY+ D + CT + + + + D
Sbjct: 1689 YKCLCLPGYVPSDKPNYCTPLNTALNLEKDSD 1720
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/65 (35%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 453 ENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDEC--ITNQHNCDENALCFNTVGGHNCV 509
EN CV + C C GY + +C + +EC + N+ + +NA C NT G + C+
Sbjct: 1633 ENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCL 1692
Query: 510 CKPGY 514
C PGY
Sbjct: 1693 CLPGY 1697
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/87 (31%), Positives = 44/87 (50%), Gaps = 9/87 (10%)
Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEH 483
C G++ R +N +C+DI+EC + + C N C+NT GS+ C CK G+ +S
Sbjct: 612 CLPGYK--RVNNTFCQDINEC-QLQGVC-PNGECLNTMGSYRCTCKIGFGPDPTFSSCVP 667
Query: 484 DECITNQHNCDENALCFNTV-GGHNCV 509
D + + +E C+ V G C+
Sbjct: 668 DPPVIS----EEKGPCYRLVSSGRQCM 690
Score = 42.0 bits (97), Expect = 0.002
Identities = 19/54 (35%), Positives = 24/54 (44%)
Query: 501 NTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCET 554
N GG C G+ K C C+NGG C+ +C C G G +CET
Sbjct: 167 NVCGGRCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPGTKGKACET 220
Score = 39.7 bits (91), Expect = 0.011
Identities = 32/109 (29%), Positives = 45/109 (41%), Gaps = 22/109 (20%)
Query: 465 MCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGT--TC- 521
M C GY R+++ C + +EC Q C N C NT+G + C CK G+ + T +C
Sbjct: 609 MMECLPGYKRVNNTFCQDINECQL-QGVCP-NGECLNTMGSYRCTCKIGFGPDPTFSSCV 666
Query: 522 ---------KAFCKDGCRNGGAC-------IAANVCACPQGFT-GPSCE 553
K C +G C + +C C G GP CE
Sbjct: 667 PDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCE 715
Score = 36.6 bits (83), Expect = 0.096
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 525 CKDGCRNGGACIAANVCACPQGFTGPSCETDIDECS 560
C C NGG C + + C CP FTG C+ + S
Sbjct: 403 CHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGAS 438
Score = 35.0 bits (79), Expect = 0.28
Identities = 22/69 (31%), Positives = 29/69 (42%), Gaps = 9/69 (13%)
Query: 527 DGCRNGGACIAAN---VCACPQGF---TGPSCETDIDECSD--GFVQCDSRANCINLPGW 578
+GC NG C+ C C G+ T D++EC + + A CIN G
Sbjct: 1630 NGCENG-RCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGS 1688
Query: 579 YHCECRDGY 587
Y C C GY
Sbjct: 1689 YKCLCLPGY 1697
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 130 bits (328), Expect = 4e-30
Identities = 129/442 (29%), Positives = 170/442 (38%), Gaps = 62/442 (14%)
Query: 333 ICQFQGRTYFEGERNTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCC 392
IC ++G + E +R V V + C + E S CP + + C
Sbjct: 574 IC-YEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEGSFLCI--CPAGFMASEEGTNC 630
Query: 393 ---KVCKGYDFCSERHNCMENSICRNLNDRAVCS-CRDGFRALREDNAYCEDIDECAEGR 448
C D C E H C N C C G+R + CEDIDEC
Sbjct: 631 IDVDECLRPDVCGEGH-------CVNTVGAFRCEYCDSGYRMTQRGR--CEDIDECLNPS 681
Query: 449 HYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC 508
E CVN+PGS+ C+ T R + C + DEC+ + N N C N G + C
Sbjct: 682 TCPDEQ--CVNSPGSYQCVPCTEGFRGWNGQCLDVDECL--EPNVCANGDCSNLEGSYMC 737
Query: 509 VCKPGYTGNGTTCKAFCK--DGCRNGGACIAANV--------CACPQGF----TGPSCET 554
C GYT T C+ D C+ G C+ C C QG+ CE
Sbjct: 738 SCHKGYT--RTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCE- 794
Query: 555 DIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCA 614
DIDEC + C + C N G + C C GY +G+ G+ CEDI+EC + C
Sbjct: 795 DIDECQHRHL-C-AHGQCRNTEGSFQCVCDQGYRASGL----GDHCEDINECLEDKSVCQ 848
Query: 615 NDTICFNLDGGYDCRCPHG------KNC--TGDCIHDGKVKHNGQIWVLENDRCSVCSCQ 666
C N G YDC CP G K C +C H G G+ L + C CQ
Sbjct: 849 RGD-CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGE--CLNTEGSFHCVCQ 905
Query: 667 NGF-VMCRRMVCDCENPTVDLFCCPE---CDPRLSS-QCLHQNGETLYNSGDTWVQNCQQ 721
GF + C+ + V+ C CD S +CL G G V + +
Sbjct: 906 QGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCV-DVNE 964
Query: 722 CRCLQGEVDCWPLPCPDVECEF 743
C L G C C +VE F
Sbjct: 965 CELLSGV--CGEAFCENVEGSF 984
Score = 130 bits (327), Expect = 5e-30
Identities = 113/384 (29%), Positives = 155/384 (40%), Gaps = 92/384 (23%)
Query: 399 DFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCV 458
D C H C NL R C C +G+R E C DIDEC + +H C + C
Sbjct: 557 DICGAGH-------CINLPVRYTCICYEGYR-FSEQQRKCVDIDECTQVQHLCSQG-RCE 607
Query: 459 NTPGSFMCICKTGYIRIDD-YSCTEHDECITNQHNCDENALCFNTVGGHNC-VCKPGYTG 516
NT GSF+CIC G++ ++ +C + DEC+ C E C NTVG C C GY
Sbjct: 608 NTEGSFLCICPAGFMASEEGTNCIDVDECL-RPDVCGEGH-CVNTVGAFRCEYCDSGYRM 665
Query: 517 -------------NGTTCK-------------AFCKDG-------CRNGGACIAANVCA- 542
N +TC C +G C + C+ NVCA
Sbjct: 666 TQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCAN 725
Query: 543 -------------CPQGFTGPSCE---TDIDECSDGFVQCDSRANCINLPGWYHCECRDG 586
C +G+T DIDEC G + + + C N G + C C G
Sbjct: 726 GDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQ--CKNTEGSFRCTCGQG 783
Query: 587 YHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTG-------- 638
Y S + + CEDIDEC RH CA+ C N +G + C C G +G
Sbjct: 784 Y----QLSAAKDQCEDIDEC-QHRHLCAHGQ-CRNTEGSFQCVCDQGYRASGLGDHCEDI 837
Query: 639 -DCIHDGKVKHNGQIWVLENDRCSVCSCQNGFVMCRRMVC----DCENPTVDLFCCP--E 691
+C+ D V G + C+C +GF + C +CE+P + C P E
Sbjct: 838 NECLEDKSVCQRGD--CINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGL---CGPQGE 892
Query: 692 C-DPRLSSQCLHQNGETLYNSGDT 714
C + S C+ Q G ++ G T
Sbjct: 893 CLNTEGSFHCVCQQGFSISADGRT 916
Score = 102 bits (253), Expect = 2e-21
Identities = 109/410 (26%), Positives = 155/410 (37%), Gaps = 107/410 (26%)
Query: 284 FESWIDGCKNCTCLNGTIQCETLICPNPDCP-------LKSALAYVDGKCCKECKSI--C 334
F W N CL+ E +C N DC Y K C+ I C
Sbjct: 704 FRGW-----NGQCLDVDECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDEC 758
Query: 335 QFQGRTYFEGE-RNTVYSSSGVC----VLYECKDQTMKLVESSGCPALDCPESHQITLSH 389
Q QG G+ +NT S C L KDQ + E H+ +H
Sbjct: 759 Q-QGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQCEDIDECQ----------HRHLCAH 807
Query: 390 SCCK--------VC-KGY------DFCSERHNCMEN-SICR-----NLNDRAVCSCRDGF 428
C+ VC +GY D C + + C+E+ S+C+ N C+C DGF
Sbjct: 808 GQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGF 867
Query: 429 RALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECI 487
+ +DN C+DI+EC E C C+NT GSF C+C+ G+ I D +C + DEC+
Sbjct: 868 QL--DDNKTCQDINEC-EHPGLCGPQGECLNTEGSFHCVCQQGFSISADGRTCEDIDECV 924
Query: 488 TNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGF 547
N CD + C NT G C+C G+ ++G C+ N C G
Sbjct: 925 NNT-VCDSHGFCDNTAGSFRCLCYQGF------------QAPQDGQGCVDVNECELLSGV 971
Query: 548 TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCE------ 601
G A C N+ G + C C D +N +SP C
Sbjct: 972 CG-------------------EAFCENVEGSFLCVCAD---ENQEYSPMTGQCRSRTSTD 1009
Query: 602 ---DIDECGTGRHSC---AND-TICFNLDG----GYDCRCPHGKNCTGDC 640
D+D+ + C ND ++C N+ +C C G +C
Sbjct: 1010 LDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNC 1059
Score = 96.3 bits (238), Expect = 1e-19
Identities = 103/361 (28%), Positives = 135/361 (37%), Gaps = 56/361 (15%)
Query: 440 DIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENAL 498
+I+EC C C+N P + CIC GY C + DEC QH C +
Sbjct: 548 EINECTVNPDICGAGH-CINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGR- 605
Query: 499 CFNTVGGHNCVCKPGYTGN--GTTC--------KAFCKDG-CRNGGACIAANVCACPQGF 547
C NT G C+C G+ + GT C C +G C N C
Sbjct: 606 CENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRM 665
Query: 548 TGPSCETDIDECSDGFVQCDSRANCINLPGWYHC-ECRDGYHD-NGMFSPSGESCEDIDE 605
T DIDEC + D + C+N PG Y C C +G+ NG C D+DE
Sbjct: 666 TQRGRCEDIDECLNPSTCPDEQ--CVNSPGSYQCVPCTEGFRGWNG-------QCLDVDE 716
Query: 606 CGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS---- 661
C + CAN C NL+G Y C C G T D H + Q + N +C
Sbjct: 717 C-LEPNVCANGD-CSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEG 774
Query: 662 --VCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWVQNC 719
C+C G+ + CE+ EC R C H G+ G
Sbjct: 775 SFRCTCGQGYQLSAAK-DQCED-------IDECQHR--HLCAH--GQCRNTEGSF----- 817
Query: 720 QQCRCLQG-EVDCWPLPCPDV-EC--EFSILPENECCPRCVTDPCQA-DTIRNDITKTCL 774
QC C QG C D+ EC + S+ +C + C D + D KTC
Sbjct: 818 -QCVCDQGYRASGLGDHCEDINECLEDKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQ 876
Query: 775 D 775
D
Sbjct: 877 D 877
Score = 90.9 bits (224), Expect = 4e-18
Identities = 104/424 (24%), Positives = 142/424 (33%), Gaps = 106/424 (25%)
Query: 289 DGCKNCTCLNG------TIQCETLICPNPDCPLKSALAYVDGKCCK---ECKSICQFQGR 339
+G CTC G QCE + +C + A+ G+C + +C R
Sbjct: 773 EGSFRCTCGQGYQLSAAKDQCEDI----DECQHRHLCAH--GQCRNTEGSFQCVCDQGYR 826
Query: 340 TYFEGER----NTVYSSSGVCVLYECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVC 395
G+ N VC +C + ++G CP+ Q+ + K C
Sbjct: 827 ASGLGDHCEDINECLEDKSVCQRGDC-------INTAGSYDCTCPDGFQLDDN----KTC 875
Query: 396 KGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENT 455
+ + C C C N C C+ GF ++ D CEDIDEC C +
Sbjct: 876 QDINECEHPGLCGPQGECLNTEGSFHCVCQQGF-SISADGRTCEDIDECVNNT-VCDSHG 933
Query: 456 MCVNTPGSFMCICKTGYIRIDD-YSCTEHDECITNQHNCDENALCFNTVGGHNCVC---K 511
C NT GSF C+C G+ D C + +EC C E A C N G CVC
Sbjct: 934 FCDNTAGSFRCLCYQGFQAPQDGQGCVDVNECELLSGVCGE-AFCENVEGSFLCVCADEN 992
Query: 512 PGYTGNGTTC------------------KAFCKDGCRNGGAC---IAANV----CACPQG 546
Y+ C K C + C +A NV C C G
Sbjct: 993 QEYSPMTGQCRSRTSTDLDVDVDQPKEEKKECYYNLNDASLCDNVLAPNVTKQECCCTSG 1052
Query: 547 FT-GPSCET-------------------------------------DIDECSDGFVQCDS 568
G +CE D DEC +
Sbjct: 1053 AGWGDNCEIFPCPVLGTAEFTEMCPKGKGFVPAGESSSEAGGENYKDADECLLFGQEICK 1112
Query: 569 RANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
C+N Y C C+ G + + P C D+DEC SC D C N +G Y+C
Sbjct: 1113 NGFCLNTRPGYECYCKQGTY----YDPVKLQCFDMDEC-QDPSSCI-DGQCVNTEGSYNC 1166
Query: 629 RCPH 632
C H
Sbjct: 1167 FCTH 1170
Score = 68.6 bits (166), Expect = 2e-11
Identities = 73/287 (25%), Positives = 106/287 (36%), Gaps = 60/287 (20%)
Query: 550 PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTG 609
P+ T+I+EC+ C + +CINLP Y C C +GY FS C DIDEC
Sbjct: 543 PTQVTEINECTVNPDICGA-GHCINLPVRYTCICYEGYR----FSEQQRKCVDIDECTQV 597
Query: 610 RHSCANDTICFNLDGGYDCRCP-------HGKNC--TGDCIHDGKVKHNGQIWVLENDRC 660
+H C+ C N +G + C CP G NC +C+ + + RC
Sbjct: 598 QHLCSQGR-CENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRC 656
Query: 661 SVCSCQNGFVMCRRMVC----DCENPTVDLFCCPECDPRLSSQCLHQNGETLYNSGDTWV 716
C +G+ M +R C +C NP+ CP+ QC++ G
Sbjct: 657 EY--CDSGYRMTQRGRCEDIDECLNPST----CPD------EQCVNSPGS---------- 694
Query: 717 QNCQQC---------RCLQGEVDCWPLPCPDVECEFSILPENECCPRCVTDPCQADTIRN 767
C C +CL + P C + +C S L + C C R
Sbjct: 695 YQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDC--SNLEGSYMC------SCHKGYTRT 746
Query: 768 DITKTC--LDEMNVVRFTGSSWIKHGTECTLCQCKNGHICCSVDPQC 812
K C +DE + K+ C C G+ + QC
Sbjct: 747 PDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKDQC 793
Score = 56.2 bits (134), Expect = 1e-07
Identities = 61/268 (22%), Positives = 84/268 (31%), Gaps = 52/268 (19%)
Query: 409 ENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCIC 468
+N C N C C+ G C D+DEC + C + CVNT GS+ C C
Sbjct: 1112 KNGFCLNTRPGYECYCKQG-TYYDPVKLQCFDMDECQDPSS-CIDG-QCVNTEGSYNCFC 1168
Query: 469 KTGYIR-IDDYSCTEHDECITNQHNCDE-NALCFNTVGGHNCVCKPGYTGNGTTCKAFCK 526
+ + C E D LC+ + +P T + C
Sbjct: 1169 THPMVLDASEKRCIRPAESNEQIEETDVYQDLCWEHLSDEYVCSRPLVGKQTTYTECCCL 1228
Query: 527 DGCRNGGACIA---------ANVCACP------------------------------QGF 547
G G C A +C P F
Sbjct: 1229 YGEAWGMQCALCPLKDSDDYAQLCNIPVTGRRQPYGRDALVDFSEQYTPEADPYFIQDRF 1288
Query: 548 TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECG 607
E +EC G + C+ + Y C+C DGYH + +C D++EC
Sbjct: 1289 LNSFEELQAEEC--GILNGCENGRCVRVQEGYTCDCFDGYH----LDTAKMTCVDVNECD 1342
Query: 608 --TGRHSCANDTICFNLDGGYDCRCPHG 633
R S + C N DG Y C C G
Sbjct: 1343 ELNNRMSLCKNAKCINTDGSYKCLCLPG 1370
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 4/92 (4%)
Query: 406 NCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAE--GRHYCRENTMCVNTPGS 463
N EN C + + C C DG+ L C D++EC E R +N C+NT GS
Sbjct: 1304 NGCENGRCVRVQEGYTCDCFDGYH-LDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGS 1362
Query: 464 FMCICKTGYIRIDDYS-CTEHDECITNQHNCD 494
+ C+C GY+ D + CT + + + + D
Sbjct: 1363 YKCLCLPGYVPSDKPNYCTPLNTALNLEKDSD 1394
Score = 48.1 bits (113), Expect = 3e-05
Identities = 23/65 (35%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 453 ENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDEC--ITNQHNCDENALCFNTVGGHNCV 509
EN CV + C C GY + +C + +EC + N+ + +NA C NT G + C+
Sbjct: 1307 ENGRCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCL 1366
Query: 510 CKPGY 514
C PGY
Sbjct: 1367 CLPGY 1371
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/87 (31%), Positives = 44/87 (50%), Gaps = 9/87 (10%)
Query: 424 CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEH 483
C G++ R +N +C+DI+EC + + C N C+NT GS+ C CK G+ +S
Sbjct: 286 CLPGYK--RVNNTFCQDINEC-QLQGVC-PNGECLNTMGSYRCTCKIGFGPDPTFSSCVP 341
Query: 484 DECITNQHNCDENALCFNTV-GGHNCV 509
D + + +E C+ V G C+
Sbjct: 342 DPPVIS----EEKGPCYRLVSSGRQCM 364
Score = 39.7 bits (91), Expect = 0.011
Identities = 32/109 (29%), Positives = 45/109 (41%), Gaps = 22/109 (20%)
Query: 465 MCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGT--TC- 521
M C GY R+++ C + +EC Q C N C NT+G + C CK G+ + T +C
Sbjct: 283 MMECLPGYKRVNNTFCQDINECQL-QGVCP-NGECLNTMGSYRCTCKIGFGPDPTFSSCV 340
Query: 522 ---------KAFCKDGCRNGGAC-------IAANVCACPQGFT-GPSCE 553
K C +G C + +C C G GP CE
Sbjct: 341 PDPPVISEEKGPCYRLVSSGRQCMHPLSVHLTKQLCCCSVGKAWGPHCE 389
Score = 36.6 bits (83), Expect = 0.096
Identities = 14/36 (38%), Positives = 18/36 (50%)
Query: 525 CKDGCRNGGACIAANVCACPQGFTGPSCETDIDECS 560
C C NGG C + + C CP FTG C+ + S
Sbjct: 77 CHLPCMNGGQCSSRDKCQCPPNFTGKLCQIPVHGAS 112
Score = 35.0 bits (79), Expect = 0.28
Identities = 22/69 (31%), Positives = 29/69 (42%), Gaps = 9/69 (13%)
Query: 527 DGCRNGGACIAAN---VCACPQGF---TGPSCETDIDECSD--GFVQCDSRANCINLPGW 578
+GC NG C+ C C G+ T D++EC + + A CIN G
Sbjct: 1304 NGCENG-RCVRVQEGYTCDCFDGYHLDTAKMTCVDVNECDELNNRMSLCKNAKCINTDGS 1362
Query: 579 YHCECRDGY 587
Y C C GY
Sbjct: 1363 YKCLCLPGY 1371
>gi|110347437 latent transforming growth factor beta binding protein
4 isoform c [Homo sapiens]
Length = 1557
Score = 129 bits (325), Expect = 8e-30
Identities = 107/394 (27%), Positives = 136/394 (34%), Gaps = 90/394 (22%)
Query: 379 CPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYC 438
CP +Q H C+ D C++ C+NL C C GFR +A
Sbjct: 589 CPAGYQAA-PHGAS--CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRG----SACE 641
Query: 439 EDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENA 497
ED+DECA+ C C NT GSF C C G+ R C + DEC + C
Sbjct: 642 EDVDECAQEPPPCGPGR-CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR 700
Query: 498 LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCE---- 553
C NT G CVC G+ N + D C N AC P F +C
Sbjct: 701 -CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHH 759
Query: 554 ------TDIDECSDGFVQCDSRANCINLPGWYHCECRDGY-------------------- 587
TD+DECS G C +C N G + C C GY
Sbjct: 760 LHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGD 819
Query: 588 ---------HDNGMFS----------PSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
+ +G F+ P G SC D+DEC IC N DG ++C
Sbjct: 820 FCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS--EEDLCQSGICTNTDGSFEC 877
Query: 629 RCPHGKNCTGD---CIHDGKVKHNGQIWVLENDRCS--------VCSCQNGFVMCRRMVC 677
CP G D C+ + + G + + RC V C G+ C
Sbjct: 878 ICPPGHRAGPDLASCLDVDECRERGPA-LCGSQRCENSPGSYRCVRDCDPGYHAGPEGTC 936
Query: 678 D-----------------CENPTVDLFCCPECDP 694
D CEN C P CDP
Sbjct: 937 DDVDECQEYGPEICGAQRCENTPGSYRCTPACDP 970
Score = 127 bits (320), Expect = 3e-29
Identities = 86/283 (30%), Positives = 115/283 (40%), Gaps = 34/283 (12%)
Query: 379 CPESHQITLSHSCCKVCKGYDFCSE-RHNCMENSICRNLNDRAVCSCRDGFRALREDNAY 437
CP H + C D CS C + C N CSC G+RA
Sbjct: 754 CPSGHHLHRGR-----CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGP 808
Query: 438 CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID-DYSCTEHDECITNQHNCDEN 496
C D++EC EG +C + C+NT GSF C C GY SC + DEC ++ + ++
Sbjct: 809 CADVNECLEG-DFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC--SEEDLCQS 865
Query: 497 ALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAAN------------VCACP 544
+C NT G C+C PG+ D CR G + + V C
Sbjct: 866 GICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 925
Query: 545 QGF-TGP--SCETDIDECSDGFVQCDSRANCINLPGWYHCE--CRDGYHDNGMFSPSGES 599
G+ GP +C+ D+DEC + + C N PG Y C C GY G
Sbjct: 926 PGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT-----PGGG 979
Query: 600 CEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIH 642
C+D+DEC R C +C NL G + C C G D H
Sbjct: 980 CQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRH 1021
Score = 124 bits (311), Expect = 4e-28
Identities = 107/353 (30%), Positives = 136/353 (38%), Gaps = 51/353 (14%)
Query: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS-C 480
C+C GFR L C D+DEC C C N+PGSF C+C G+ + C
Sbjct: 503 CACDSGFR-LSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAEC 560
Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG--NGTTCKAFCK----DGCRNGGA 534
+ DEC CD C NT G CVC GY +G +C+ + G GA
Sbjct: 561 LDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA 619
Query: 535 CI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNG 591
C + C CP GF G +CE D+DEC+ C C N G +HC C G+ G
Sbjct: 620 CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFRSRG 678
Query: 592 MFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG--KNCTGDCIHDGKVKHN 649
G C+D+DEC C C N +G + C CP G N G D N
Sbjct: 679 ----PGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGFQPNTAGSECEDVDECEN 733
Query: 650 -----GQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQN 704
GQ V +C +G + R D + + P C P C +
Sbjct: 734 HLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSG---APPCGPH--GHCTNTE 788
Query: 705 GETLYNSGDTWVQNCQQCRCLQG--EVDCWPLPCPDV-EC---EFSILPENEC 751
G +C C G P PC DV EC +F P EC
Sbjct: 789 GSF-------------RCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGEC 827
Score = 117 bits (292), Expect = 6e-26
Identities = 88/270 (32%), Positives = 119/270 (44%), Gaps = 35/270 (12%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C + C E C + C N + C+C G+R A C D+DEC+E C+
Sbjct: 809 CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRP-GPRGASCLDVDECSE-EDLCQSG 866
Query: 455 TMCVNTPGSFMCICKTGYIRIDDY-SCTEHDECITNQHNCDENALCFNTVGGHNCV--CK 511
+C NT GSF CIC G+ D SC + DEC + C N+ G + CV C
Sbjct: 867 -ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 925
Query: 512 PGY-TGNGTTCKAFCKDGCRNGGACIA-ANVC-----------ACPQGFT---GPSCETD 555
PGY G TC D C+ G I A C AC G+ G C+ D
Sbjct: 926 PGYHAGPEGTCDDV--DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ-D 982
Query: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 615
+DEC + C + A C NLPG + C C GY + G C D++EC T + C
Sbjct: 983 VDECRNRSF-CGAHAVCQNLPGSFQCLCDQGYEG----ARDGRHCVDVNECETLQGVC-G 1036
Query: 616 DTICFNLDGGYDCRCPHGKN----CTGDCI 641
+C N++G + C CP+ TG C+
Sbjct: 1037 AALCENVEGSFLCVCPNSPEEFDPMTGRCV 1066
Score = 78.6 bits (192), Expect = 2e-14
Identities = 66/207 (31%), Positives = 86/207 (41%), Gaps = 34/207 (16%)
Query: 360 ECKDQTMKLVESSGCPALD------CPESHQITLSHSCCKVCKGYDFCSERHNCMENSI- 412
EC ++ L +S C D CP H+ + C D C ER + S
Sbjct: 856 ECSEED--LCQSGICTNTDGSFECICPPGHRAGPDLASCL---DVDECRERGPALCGSQR 910
Query: 413 CRNL--NDRAVCSCRDGFRALREDNAYCEDIDECAE-GRHYCRENTMCVNTPGSFMCI-- 467
C N + R V C G+ A E C+D+DEC E G C C NTPGS+ C
Sbjct: 911 CENSPGSYRCVRDCDPGYHAGPEGT--CDDVDECQEYGPEICGAQR-CENTPGSYRCTPA 967
Query: 468 CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKD 527
C GY C + DEC N+ C +A+C N G C+C GY +
Sbjct: 968 CDPGYQPTPGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGY------------E 1014
Query: 528 GCRNGGACIAANVCACPQGFTGPS-CE 553
G R+G C+ N C QG G + CE
Sbjct: 1015 GARDGRHCVDVNECETLQGVCGAALCE 1041
Score = 72.0 bits (175), Expect = 2e-12
Identities = 90/384 (23%), Positives = 127/384 (33%), Gaps = 96/384 (25%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C+ D C R C +++C+NL C C G+ R D +C D++EC + C
Sbjct: 980 CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR-DGRHCVDVNECETLQGVCGA- 1037
Query: 455 TMCVNTPGSFMCICKTGYIRIDDYS--CTEHDECITNQHNCDENALCFNTVGGHN----- 507
+C N GSF+C+C D + C A +
Sbjct: 1038 ALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPL 1097
Query: 508 ----CVCKPGYTGNGTTCKAF---CKDGCRNGGACIAANV----CACPQGFT-GPSCETD 555
+ G G+G F D C N +A NV C C G G C
Sbjct: 1098 PRRPSTPRQGPVGSGRRECYFDTAAPDACDN---ILARNVTWQECCCTVGEGWGSGCR-- 1152
Query: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC--EDIDECGTGRHSC 613
I +C G + ++ C H G +PSG+ D+DEC R
Sbjct: 1153 IQQCP-GTETAEYQSLCP--------------HGRGYLAPSGDLSLRRDVDECQLFRDQV 1197
Query: 614 ANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS--VCSCQNGFVM 671
+C N GY C C +G H ++ ++ND C+ +C+ G
Sbjct: 1198 CKSGVCVNTAPGYSCYC-----------SNGYYYHTQRLECIDNDECADEEPACEGG--R 1244
Query: 672 CRRMV----CDCENPTV-----------------------------DLFCCPECDPRLSS 698
C V C CE P V DL C PRL
Sbjct: 1245 CVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVC---SHPRLDR 1301
Query: 699 QCLHQNGETLYNSGDTWVQNCQQC 722
Q + LY G+ W +C C
Sbjct: 1302 QATYTECCCLY--GEAWGMDCALC 1323
Score = 67.8 bits (164), Expect = 4e-11
Identities = 38/139 (27%), Positives = 60/139 (43%), Gaps = 5/139 (3%)
Query: 382 SHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDI 441
+ +T CC V +G+ C +++C G+ A D + D+
Sbjct: 1131 ARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEY---QSLCPHGRGYLAPSGDLSLRRDV 1187
Query: 442 DECAEGRHYCRENTMCVNTPGSFMCICKTG-YIRIDDYSCTEHDECITNQHNCDENALCF 500
DEC R ++ +CVNT + C C G Y C ++DEC + C E C
Sbjct: 1188 DECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCV 1246
Query: 501 NTVGGHNCVCKPGYTGNGT 519
NTVG ++C C+P +G+
Sbjct: 1247 NTVGSYHCTCEPPLVLDGS 1265
Score = 63.9 bits (154), Expect = 6e-10
Identities = 49/166 (29%), Positives = 68/166 (40%), Gaps = 26/166 (15%)
Query: 360 ECKDQTMKLVESSGCP--------ALDCPESHQITLSHSCCKV--CKGY--DFCSERHNC 407
EC+++ L S C DC + +C V C+ Y + C +
Sbjct: 897 ECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQR-- 954
Query: 408 MENSICRNLNDRAVCS--CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
C N C+ C G++ C+D+DEC R +C + +C N PGSF
Sbjct: 955 -----CENTPGSYRCTPACDPGYQPT--PGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQ 1006
Query: 466 CICKTGYIRI-DDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
C+C GY D C + +EC T Q C ALC N G CVC
Sbjct: 1007 CLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVEGSFLCVC 1051
Score = 48.1 bits (113), Expect = 3e-05
Identities = 26/65 (40%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 410 NSICRNLNDRAVCSCRDGFRALREDNAYCEDIDEC--AEGRHYCRENTMCVNTPGSFMCI 467
N C + + C C DG+R L C DI+EC AE N C+NT GSF CI
Sbjct: 1478 NGRCVRVPEGFTCRCFDGYR-LDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1536
Query: 468 CKTGY 472
C+ G+
Sbjct: 1537 CRPGF 1541
Score = 47.4 bits (111), Expect = 5e-05
Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 13/81 (16%)
Query: 438 CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID--DYSCTEHDECITNQHNCD- 494
C +D C GR CV P F C C GY R+D +C + +EC +
Sbjct: 1470 CGILDGCTNGR--------CVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEAASPL 1520
Query: 495 -ENALCFNTVGGHNCVCKPGY 514
NA C NT G C+C+PG+
Sbjct: 1521 CVNARCLNTDGSFRCICRPGF 1541
Score = 46.2 bits (108), Expect = 1e-04
Identities = 32/117 (27%), Positives = 48/117 (41%), Gaps = 13/117 (11%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCS---CRDGFRALREDNAYCEDIDECAEGRHYC 451
C+G H+C S ++R C GF + N CED+DECA G C
Sbjct: 245 CRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERV---NGSCEDVDECATGGR-C 300
Query: 452 RENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC 508
+ C NT G + C+C G++ +D + CI+ + CF + C
Sbjct: 301 QHGE-CANTRGGYTCVCPDGFL-LD----SSRSSCISQHVISEAKGPCFRVLRDGGC 351
Score = 43.9 bits (102), Expect = 6e-04
Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 10/87 (11%)
Query: 550 PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTG 609
P E + +EC G + + C+ +P + C C DGY + +C DI+EC
Sbjct: 1461 PYEELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDGYR----LDMTRMACVDINECDEA 1514
Query: 610 RHS---CANDTICFNLDGGYDCRCPHG 633
+ C N C N DG + C C G
Sbjct: 1515 EAASPLCVN-ARCLNTDGSFRCICRPG 1540
Score = 41.6 bits (96), Expect = 0.003
Identities = 38/132 (28%), Positives = 57/132 (43%), Gaps = 27/132 (20%)
Query: 468 CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY--TGNGTTC---- 521
C TG+ R++ SC + DEC T C ++ C NT GG+ CVC G+ + ++C
Sbjct: 277 CPTGFERVNG-SCEDVDECATGGR-C-QHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 333
Query: 522 -----KAFCKDGCRNGGAC------IAANVCACPQ--GFTGPSCETDIDECSDGFVQCDS 568
K C R+GG I +C C + G C+ S+GF
Sbjct: 334 VISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGF----- 388
Query: 569 RANCINLPGWYH 580
R C PG+++
Sbjct: 389 REICPAGPGYHY 400
Score = 40.8 bits (94), Expect = 0.005
Identities = 18/35 (51%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Query: 599 SCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
SCED+DEC TG + C N GGY C CP G
Sbjct: 287 SCEDVDECATGGRCQHGE--CANTRGGYTCVCPDG 319
Score = 38.9 bits (89), Expect = 0.019
Identities = 34/116 (29%), Positives = 44/116 (37%), Gaps = 22/116 (18%)
Query: 499 CFNTVGGHNCVCK-PGYTGNGTTCKA-----------FCKDGCRNGGACIAANVCACPQG 546
CF + G C PG C+ C + N ++A CP G
Sbjct: 222 CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSER-VSAPDGPCPTG 280
Query: 547 F--TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
F SCE D+DEC+ G +C C N G Y C C DG+ + S SC
Sbjct: 281 FERVNGSCE-DVDECATGG-RCQ-HGECANTRGGYTCVCPDGF----LLDSSRSSC 329
Score = 35.4 bits (80), Expect = 0.21
Identities = 16/42 (38%), Positives = 20/42 (47%), Gaps = 1/42 (2%)
Query: 513 GYTGNGTTCKAF-CKDGCRNGGACIAANVCACPQGFTGPSCE 553
G G +AF C C NGG C+ + C CP F G C+
Sbjct: 73 GAAPGGPGFRAFLCPLICHNGGVCVKPDRCLCPPDFAGKFCQ 114
Score = 35.0 bits (79), Expect = 0.28
Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 11/70 (15%)
Query: 527 DGCRNGGACIAAN---VCACPQGF----TGPSCETDIDECSDGFVQCDS--RANCINLPG 577
DGC NG C+ C C G+ T +C DI+EC + A C+N G
Sbjct: 1474 DGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARCLNTDG 1531
Query: 578 WYHCECRDGY 587
+ C CR G+
Sbjct: 1532 SFRCICRPGF 1541
>gi|110347412 latent transforming growth factor beta binding protein 4
isoform b [Homo sapiens]
Length = 1587
Score = 129 bits (325), Expect = 8e-30
Identities = 107/394 (27%), Positives = 136/394 (34%), Gaps = 90/394 (22%)
Query: 379 CPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYC 438
CP +Q H C+ D C++ C+NL C C GFR +A
Sbjct: 619 CPAGYQAA-PHGAS--CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRG----SACE 671
Query: 439 EDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENA 497
ED+DECA+ C C NT GSF C C G+ R C + DEC + C
Sbjct: 672 EDVDECAQEPPPCGPGR-CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR 730
Query: 498 LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCE---- 553
C NT G CVC G+ N + D C N AC P F +C
Sbjct: 731 -CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHH 789
Query: 554 ------TDIDECSDGFVQCDSRANCINLPGWYHCECRDGY-------------------- 587
TD+DECS G C +C N G + C C GY
Sbjct: 790 LHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGD 849
Query: 588 ---------HDNGMFS----------PSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
+ +G F+ P G SC D+DEC IC N DG ++C
Sbjct: 850 FCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS--EEDLCQSGICTNTDGSFEC 907
Query: 629 RCPHGKNCTGD---CIHDGKVKHNGQIWVLENDRCS--------VCSCQNGFVMCRRMVC 677
CP G D C+ + + G + + RC V C G+ C
Sbjct: 908 ICPPGHRAGPDLASCLDVDECRERGPA-LCGSQRCENSPGSYRCVRDCDPGYHAGPEGTC 966
Query: 678 D-----------------CENPTVDLFCCPECDP 694
D CEN C P CDP
Sbjct: 967 DDVDECQEYGPEICGAQRCENTPGSYRCTPACDP 1000
Score = 127 bits (320), Expect = 3e-29
Identities = 86/283 (30%), Positives = 115/283 (40%), Gaps = 34/283 (12%)
Query: 379 CPESHQITLSHSCCKVCKGYDFCSE-RHNCMENSICRNLNDRAVCSCRDGFRALREDNAY 437
CP H + C D CS C + C N CSC G+RA
Sbjct: 784 CPSGHHLHRGR-----CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGP 838
Query: 438 CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID-DYSCTEHDECITNQHNCDEN 496
C D++EC EG +C + C+NT GSF C C GY SC + DEC ++ + ++
Sbjct: 839 CADVNECLEG-DFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC--SEEDLCQS 895
Query: 497 ALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAAN------------VCACP 544
+C NT G C+C PG+ D CR G + + V C
Sbjct: 896 GICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 955
Query: 545 QGF-TGP--SCETDIDECSDGFVQCDSRANCINLPGWYHCE--CRDGYHDNGMFSPSGES 599
G+ GP +C+ D+DEC + + C N PG Y C C GY G
Sbjct: 956 PGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT-----PGGG 1009
Query: 600 CEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIH 642
C+D+DEC R C +C NL G + C C G D H
Sbjct: 1010 CQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRH 1051
Score = 124 bits (311), Expect = 4e-28
Identities = 107/353 (30%), Positives = 136/353 (38%), Gaps = 51/353 (14%)
Query: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS-C 480
C+C GFR L C D+DEC C C N+PGSF C+C G+ + C
Sbjct: 533 CACDSGFR-LSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAEC 590
Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG--NGTTCKAFCK----DGCRNGGA 534
+ DEC CD C NT G CVC GY +G +C+ + G GA
Sbjct: 591 LDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA 649
Query: 535 CI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNG 591
C + C CP GF G +CE D+DEC+ C C N G +HC C G+ G
Sbjct: 650 CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFRSRG 708
Query: 592 MFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG--KNCTGDCIHDGKVKHN 649
G C+D+DEC C C N +G + C CP G N G D N
Sbjct: 709 ----PGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGFQPNTAGSECEDVDECEN 763
Query: 650 -----GQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQN 704
GQ V +C +G + R D + + P C P C +
Sbjct: 764 HLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSG---APPCGPH--GHCTNTE 818
Query: 705 GETLYNSGDTWVQNCQQCRCLQG--EVDCWPLPCPDV-EC---EFSILPENEC 751
G +C C G P PC DV EC +F P EC
Sbjct: 819 GSF-------------RCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGEC 857
Score = 117 bits (292), Expect = 6e-26
Identities = 88/270 (32%), Positives = 119/270 (44%), Gaps = 35/270 (12%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C + C E C + C N + C+C G+R A C D+DEC+E C+
Sbjct: 839 CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRP-GPRGASCLDVDECSE-EDLCQSG 896
Query: 455 TMCVNTPGSFMCICKTGYIRIDDY-SCTEHDECITNQHNCDENALCFNTVGGHNCV--CK 511
+C NT GSF CIC G+ D SC + DEC + C N+ G + CV C
Sbjct: 897 -ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 955
Query: 512 PGY-TGNGTTCKAFCKDGCRNGGACIA-ANVC-----------ACPQGFT---GPSCETD 555
PGY G TC D C+ G I A C AC G+ G C+ D
Sbjct: 956 PGYHAGPEGTCDDV--DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ-D 1012
Query: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 615
+DEC + C + A C NLPG + C C GY + G C D++EC T + C
Sbjct: 1013 VDECRNRSF-CGAHAVCQNLPGSFQCLCDQGYEG----ARDGRHCVDVNECETLQGVC-G 1066
Query: 616 DTICFNLDGGYDCRCPHGKN----CTGDCI 641
+C N++G + C CP+ TG C+
Sbjct: 1067 AALCENVEGSFLCVCPNSPEEFDPMTGRCV 1096
Score = 78.6 bits (192), Expect = 2e-14
Identities = 66/207 (31%), Positives = 86/207 (41%), Gaps = 34/207 (16%)
Query: 360 ECKDQTMKLVESSGCPALD------CPESHQITLSHSCCKVCKGYDFCSERHNCMENSI- 412
EC ++ L +S C D CP H+ + C D C ER + S
Sbjct: 886 ECSEED--LCQSGICTNTDGSFECICPPGHRAGPDLASCL---DVDECRERGPALCGSQR 940
Query: 413 CRNL--NDRAVCSCRDGFRALREDNAYCEDIDECAE-GRHYCRENTMCVNTPGSFMCI-- 467
C N + R V C G+ A E C+D+DEC E G C C NTPGS+ C
Sbjct: 941 CENSPGSYRCVRDCDPGYHAGPEGT--CDDVDECQEYGPEICGAQR-CENTPGSYRCTPA 997
Query: 468 CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKD 527
C GY C + DEC N+ C +A+C N G C+C GY +
Sbjct: 998 CDPGYQPTPGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGY------------E 1044
Query: 528 GCRNGGACIAANVCACPQGFTGPS-CE 553
G R+G C+ N C QG G + CE
Sbjct: 1045 GARDGRHCVDVNECETLQGVCGAALCE 1071
Score = 72.0 bits (175), Expect = 2e-12
Identities = 90/384 (23%), Positives = 127/384 (33%), Gaps = 96/384 (25%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C+ D C R C +++C+NL C C G+ R D +C D++EC + C
Sbjct: 1010 CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR-DGRHCVDVNECETLQGVCGA- 1067
Query: 455 TMCVNTPGSFMCICKTGYIRIDDYS--CTEHDECITNQHNCDENALCFNTVGGHN----- 507
+C N GSF+C+C D + C A +
Sbjct: 1068 ALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPL 1127
Query: 508 ----CVCKPGYTGNGTTCKAF---CKDGCRNGGACIAANV----CACPQGFT-GPSCETD 555
+ G G+G F D C N +A NV C C G G C
Sbjct: 1128 PRRPSTPRQGPVGSGRRECYFDTAAPDACDN---ILARNVTWQECCCTVGEGWGSGCR-- 1182
Query: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC--EDIDECGTGRHSC 613
I +C G + ++ C H G +PSG+ D+DEC R
Sbjct: 1183 IQQCP-GTETAEYQSLCP--------------HGRGYLAPSGDLSLRRDVDECQLFRDQV 1227
Query: 614 ANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS--VCSCQNGFVM 671
+C N GY C C +G H ++ ++ND C+ +C+ G
Sbjct: 1228 CKSGVCVNTAPGYSCYC-----------SNGYYYHTQRLECIDNDECADEEPACEGG--R 1274
Query: 672 CRRMV----CDCENPTV-----------------------------DLFCCPECDPRLSS 698
C V C CE P V DL C PRL
Sbjct: 1275 CVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVC---SHPRLDR 1331
Query: 699 QCLHQNGETLYNSGDTWVQNCQQC 722
Q + LY G+ W +C C
Sbjct: 1332 QATYTECCCLY--GEAWGMDCALC 1353
Score = 67.8 bits (164), Expect = 4e-11
Identities = 38/139 (27%), Positives = 60/139 (43%), Gaps = 5/139 (3%)
Query: 382 SHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDI 441
+ +T CC V +G+ C +++C G+ A D + D+
Sbjct: 1161 ARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEY---QSLCPHGRGYLAPSGDLSLRRDV 1217
Query: 442 DECAEGRHYCRENTMCVNTPGSFMCICKTG-YIRIDDYSCTEHDECITNQHNCDENALCF 500
DEC R ++ +CVNT + C C G Y C ++DEC + C E C
Sbjct: 1218 DECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCV 1276
Query: 501 NTVGGHNCVCKPGYTGNGT 519
NTVG ++C C+P +G+
Sbjct: 1277 NTVGSYHCTCEPPLVLDGS 1295
Score = 63.9 bits (154), Expect = 6e-10
Identities = 49/166 (29%), Positives = 68/166 (40%), Gaps = 26/166 (15%)
Query: 360 ECKDQTMKLVESSGCP--------ALDCPESHQITLSHSCCKV--CKGY--DFCSERHNC 407
EC+++ L S C DC + +C V C+ Y + C +
Sbjct: 927 ECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQR-- 984
Query: 408 MENSICRNLNDRAVCS--CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
C N C+ C G++ C+D+DEC R +C + +C N PGSF
Sbjct: 985 -----CENTPGSYRCTPACDPGYQPT--PGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQ 1036
Query: 466 CICKTGYIRI-DDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
C+C GY D C + +EC T Q C ALC N G CVC
Sbjct: 1037 CLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVEGSFLCVC 1081
Score = 48.1 bits (113), Expect = 3e-05
Identities = 26/65 (40%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 410 NSICRNLNDRAVCSCRDGFRALREDNAYCEDIDEC--AEGRHYCRENTMCVNTPGSFMCI 467
N C + + C C DG+R L C DI+EC AE N C+NT GSF CI
Sbjct: 1508 NGRCVRVPEGFTCRCFDGYR-LDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1566
Query: 468 CKTGY 472
C+ G+
Sbjct: 1567 CRPGF 1571
Score = 47.4 bits (111), Expect = 5e-05
Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 13/81 (16%)
Query: 438 CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID--DYSCTEHDECITNQHNCD- 494
C +D C GR CV P F C C GY R+D +C + +EC +
Sbjct: 1500 CGILDGCTNGR--------CVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEAASPL 1550
Query: 495 -ENALCFNTVGGHNCVCKPGY 514
NA C NT G C+C+PG+
Sbjct: 1551 CVNARCLNTDGSFRCICRPGF 1571
Score = 46.2 bits (108), Expect = 1e-04
Identities = 32/117 (27%), Positives = 48/117 (41%), Gaps = 13/117 (11%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCS---CRDGFRALREDNAYCEDIDECAEGRHYC 451
C+G H+C S ++R C GF + N CED+DECA G C
Sbjct: 275 CRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERV---NGSCEDVDECATGGR-C 330
Query: 452 RENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC 508
+ C NT G + C+C G++ +D + CI+ + CF + C
Sbjct: 331 QHGE-CANTRGGYTCVCPDGFL-LD----SSRSSCISQHVISEAKGPCFRVLRDGGC 381
Score = 43.9 bits (102), Expect = 6e-04
Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 10/87 (11%)
Query: 550 PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTG 609
P E + +EC G + + C+ +P + C C DGY + +C DI+EC
Sbjct: 1491 PYEELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDGYR----LDMTRMACVDINECDEA 1544
Query: 610 RHS---CANDTICFNLDGGYDCRCPHG 633
+ C N C N DG + C C G
Sbjct: 1545 EAASPLCVN-ARCLNTDGSFRCICRPG 1570
Score = 41.6 bits (96), Expect = 0.003
Identities = 38/132 (28%), Positives = 57/132 (43%), Gaps = 27/132 (20%)
Query: 468 CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY--TGNGTTC---- 521
C TG+ R++ SC + DEC T C ++ C NT GG+ CVC G+ + ++C
Sbjct: 307 CPTGFERVNG-SCEDVDECATGGR-C-QHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 363
Query: 522 -----KAFCKDGCRNGGAC------IAANVCACPQ--GFTGPSCETDIDECSDGFVQCDS 568
K C R+GG I +C C + G C+ S+GF
Sbjct: 364 VISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGF----- 418
Query: 569 RANCINLPGWYH 580
R C PG+++
Sbjct: 419 REICPAGPGYHY 430
Score = 40.8 bits (94), Expect = 0.005
Identities = 18/35 (51%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Query: 599 SCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
SCED+DEC TG + C N GGY C CP G
Sbjct: 317 SCEDVDECATGGRCQHGE--CANTRGGYTCVCPDG 349
Score = 38.9 bits (89), Expect = 0.019
Identities = 34/116 (29%), Positives = 44/116 (37%), Gaps = 22/116 (18%)
Query: 499 CFNTVGGHNCVCK-PGYTGNGTTCKA-----------FCKDGCRNGGACIAANVCACPQG 546
CF + G C PG C+ C + N ++A CP G
Sbjct: 252 CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSER-VSAPDGPCPTG 310
Query: 547 F--TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
F SCE D+DEC+ G +C C N G Y C C DG+ + S SC
Sbjct: 311 FERVNGSCE-DVDECATGG-RCQ-HGECANTRGGYTCVCPDGF----LLDSSRSSC 359
Score = 35.0 bits (79), Expect = 0.28
Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 11/70 (15%)
Query: 527 DGCRNGGACIAAN---VCACPQGF----TGPSCETDIDECSDGFVQCDS--RANCINLPG 577
DGC NG C+ C C G+ T +C DI+EC + A C+N G
Sbjct: 1504 DGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARCLNTDG 1561
Query: 578 WYHCECRDGY 587
+ C CR G+
Sbjct: 1562 SFRCICRPGF 1571
Score = 34.3 bits (77), Expect = 0.48
Identities = 11/25 (44%), Positives = 14/25 (56%)
Query: 529 CRNGGACIAANVCACPQGFTGPSCE 553
C NGG C+ + C CP F G C+
Sbjct: 120 CHNGGVCVKPDRCLCPPDFAGKFCQ 144
>gi|110347431 latent transforming growth factor beta binding protein 4
isoform a [Homo sapiens]
Length = 1624
Score = 129 bits (325), Expect = 8e-30
Identities = 107/394 (27%), Positives = 136/394 (34%), Gaps = 90/394 (22%)
Query: 379 CPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYC 438
CP +Q H C+ D C++ C+NL C C GFR +A
Sbjct: 656 CPAGYQAA-PHGAS--CQDVDECTQSPGLCGRGACKNLPGSFRCVCPAGFRG----SACE 708
Query: 439 EDIDECAEGRHYCRENTMCVNTPGSFMCICKTGY-IRIDDYSCTEHDECITNQHNCDENA 497
ED+DECA+ C C NT GSF C C G+ R C + DEC + C
Sbjct: 709 EDVDECAQEPPPCGPGR-CDNTAGSFHCACPAGFRSRGPGAPCQDVDECARSPPPCTYGR 767
Query: 498 LCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCE---- 553
C NT G CVC G+ N + D C N AC P F +C
Sbjct: 768 -CENTEGSFQCVCPMGFQPNTAGSECEDVDECENHLACPGQECVNSPGSFQCRTCPSGHH 826
Query: 554 ------TDIDECSDGFVQCDSRANCINLPGWYHCECRDGY-------------------- 587
TD+DECS G C +C N G + C C GY
Sbjct: 827 LHRGRCTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGPCADVNECLEGD 886
Query: 588 ---------HDNGMFS----------PSGESCEDIDECGTGRHSCANDTICFNLDGGYDC 628
+ +G F+ P G SC D+DEC IC N DG ++C
Sbjct: 887 FCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDECS--EEDLCQSGICTNTDGSFEC 944
Query: 629 RCPHGKNCTGD---CIHDGKVKHNGQIWVLENDRCS--------VCSCQNGFVMCRRMVC 677
CP G D C+ + + G + + RC V C G+ C
Sbjct: 945 ICPPGHRAGPDLASCLDVDECRERGPA-LCGSQRCENSPGSYRCVRDCDPGYHAGPEGTC 1003
Query: 678 D-----------------CENPTVDLFCCPECDP 694
D CEN C P CDP
Sbjct: 1004 DDVDECQEYGPEICGAQRCENTPGSYRCTPACDP 1037
Score = 127 bits (320), Expect = 3e-29
Identities = 86/283 (30%), Positives = 115/283 (40%), Gaps = 34/283 (12%)
Query: 379 CPESHQITLSHSCCKVCKGYDFCSE-RHNCMENSICRNLNDRAVCSCRDGFRALREDNAY 437
CP H + C D CS C + C N CSC G+RA
Sbjct: 821 CPSGHHLHRGR-----CTDVDECSSGAPPCGPHGHCTNTEGSFRCSCAPGYRAPSGRPGP 875
Query: 438 CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID-DYSCTEHDECITNQHNCDEN 496
C D++EC EG +C + C+NT GSF C C GY SC + DEC ++ + ++
Sbjct: 876 CADVNECLEG-DFCFPHGECLNTDGSFACTCAPGYRPGPRGASCLDVDEC--SEEDLCQS 932
Query: 497 ALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAAN------------VCACP 544
+C NT G C+C PG+ D CR G + + V C
Sbjct: 933 GICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 992
Query: 545 QGF-TGP--SCETDIDECSDGFVQCDSRANCINLPGWYHCE--CRDGYHDNGMFSPSGES 599
G+ GP +C+ D+DEC + + C N PG Y C C GY G
Sbjct: 993 PGYHAGPEGTCD-DVDECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPT-----PGGG 1046
Query: 600 CEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCIH 642
C+D+DEC R C +C NL G + C C G D H
Sbjct: 1047 CQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGYEGARDGRH 1088
Score = 124 bits (311), Expect = 4e-28
Identities = 107/353 (30%), Positives = 136/353 (38%), Gaps = 51/353 (14%)
Query: 422 CSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYS-C 480
C+C GFR L C D+DEC C C N+PGSF C+C G+ + C
Sbjct: 570 CACDSGFR-LSPQGTRCIDVDECRRVPPPCAPGR-CENSPGSFRCVCGPGFRAGPRAAEC 627
Query: 481 TEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTG--NGTTCKAFCK----DGCRNGGA 534
+ DEC CD C NT G CVC GY +G +C+ + G GA
Sbjct: 628 LDVDECHRVPPPCDLGR-CENTPGSFLCVCPAGYQAAPHGASCQDVDECTQSPGLCGRGA 686
Query: 535 CI---AANVCACPQGFTGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNG 591
C + C CP GF G +CE D+DEC+ C C N G +HC C G+ G
Sbjct: 687 CKNLPGSFRCVCPAGFRGSACEEDVDECAQEPPPC-GPGRCDNTAGSFHCACPAGFRSRG 745
Query: 592 MFSPSGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG--KNCTGDCIHDGKVKHN 649
G C+D+DEC C C N +G + C CP G N G D N
Sbjct: 746 ----PGAPCQDVDECARSPPPCTYGR-CENTEGSFQCVCPMGFQPNTAGSECEDVDECEN 800
Query: 650 -----GQIWVLENDRCSVCSCQNGFVMCRRMVCDCENPTVDLFCCPECDPRLSSQCLHQN 704
GQ V +C +G + R D + + P C P C +
Sbjct: 801 HLACPGQECVNSPGSFQCRTCPSGHHLHRGRCTDVDECSSG---APPCGPH--GHCTNTE 855
Query: 705 GETLYNSGDTWVQNCQQCRCLQG--EVDCWPLPCPDV-EC---EFSILPENEC 751
G +C C G P PC DV EC +F P EC
Sbjct: 856 GSF-------------RCSCAPGYRAPSGRPGPCADVNECLEGDF-CFPHGEC 894
Score = 117 bits (292), Expect = 6e-26
Identities = 88/270 (32%), Positives = 119/270 (44%), Gaps = 35/270 (12%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C + C E C + C N + C+C G+R A C D+DEC+E C+
Sbjct: 876 CADVNECLEGDFCFPHGECLNTDGSFACTCAPGYRP-GPRGASCLDVDECSE-EDLCQSG 933
Query: 455 TMCVNTPGSFMCICKTGYIRIDDY-SCTEHDECITNQHNCDENALCFNTVGGHNCV--CK 511
+C NT GSF CIC G+ D SC + DEC + C N+ G + CV C
Sbjct: 934 -ICTNTDGSFECICPPGHRAGPDLASCLDVDECRERGPALCGSQRCENSPGSYRCVRDCD 992
Query: 512 PGY-TGNGTTCKAFCKDGCRNGGACIA-ANVC-----------ACPQGFT---GPSCETD 555
PGY G TC D C+ G I A C AC G+ G C+ D
Sbjct: 993 PGYHAGPEGTCDDV--DECQEYGPEICGAQRCENTPGSYRCTPACDPGYQPTPGGGCQ-D 1049
Query: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTGRHSCAN 615
+DEC + C + A C NLPG + C C GY + G C D++EC T + C
Sbjct: 1050 VDECRNRSF-CGAHAVCQNLPGSFQCLCDQGYEG----ARDGRHCVDVNECETLQGVC-G 1103
Query: 616 DTICFNLDGGYDCRCPHGKN----CTGDCI 641
+C N++G + C CP+ TG C+
Sbjct: 1104 AALCENVEGSFLCVCPNSPEEFDPMTGRCV 1133
Score = 78.6 bits (192), Expect = 2e-14
Identities = 66/207 (31%), Positives = 86/207 (41%), Gaps = 34/207 (16%)
Query: 360 ECKDQTMKLVESSGCPALD------CPESHQITLSHSCCKVCKGYDFCSERHNCMENSI- 412
EC ++ L +S C D CP H+ + C D C ER + S
Sbjct: 923 ECSEED--LCQSGICTNTDGSFECICPPGHRAGPDLASCL---DVDECRERGPALCGSQR 977
Query: 413 CRNL--NDRAVCSCRDGFRALREDNAYCEDIDECAE-GRHYCRENTMCVNTPGSFMCI-- 467
C N + R V C G+ A E C+D+DEC E G C C NTPGS+ C
Sbjct: 978 CENSPGSYRCVRDCDPGYHAGPEGT--CDDVDECQEYGPEICGAQR-CENTPGSYRCTPA 1034
Query: 468 CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKD 527
C GY C + DEC N+ C +A+C N G C+C GY +
Sbjct: 1035 CDPGYQPTPGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQCLCDQGY------------E 1081
Query: 528 GCRNGGACIAANVCACPQGFTGPS-CE 553
G R+G C+ N C QG G + CE
Sbjct: 1082 GARDGRHCVDVNECETLQGVCGAALCE 1108
Score = 72.0 bits (175), Expect = 2e-12
Identities = 90/384 (23%), Positives = 127/384 (33%), Gaps = 96/384 (25%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCREN 454
C+ D C R C +++C+NL C C G+ R D +C D++EC + C
Sbjct: 1047 CQDVDECRNRSFCGAHAVCQNLPGSFQCLCDQGYEGAR-DGRHCVDVNECETLQGVCGA- 1104
Query: 455 TMCVNTPGSFMCICKTGYIRIDDYS--CTEHDECITNQHNCDENALCFNTVGGHN----- 507
+C N GSF+C+C D + C A +
Sbjct: 1105 ALCENVEGSFLCVCPNSPEEFDPMTGRCVPPRTSAGTFPGSQPQAPASPVLPARPPPPPL 1164
Query: 508 ----CVCKPGYTGNGTTCKAF---CKDGCRNGGACIAANV----CACPQGFT-GPSCETD 555
+ G G+G F D C N +A NV C C G G C
Sbjct: 1165 PRRPSTPRQGPVGSGRRECYFDTAAPDACDN---ILARNVTWQECCCTVGEGWGSGCR-- 1219
Query: 556 IDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC--EDIDECGTGRHSC 613
I +C G + ++ C H G +PSG+ D+DEC R
Sbjct: 1220 IQQCP-GTETAEYQSLCP--------------HGRGYLAPSGDLSLRRDVDECQLFRDQV 1264
Query: 614 ANDTICFNLDGGYDCRCPHGKNCTGDCIHDGKVKHNGQIWVLENDRCS--VCSCQNGFVM 671
+C N GY C C +G H ++ ++ND C+ +C+ G
Sbjct: 1265 CKSGVCVNTAPGYSCYC-----------SNGYYYHTQRLECIDNDECADEEPACEGG--R 1311
Query: 672 CRRMV----CDCENPTV-----------------------------DLFCCPECDPRLSS 698
C V C CE P V DL C PRL
Sbjct: 1312 CVNTVGSYHCTCEPPLVLDGSQRRCVSNESQSLDDNLGVCWQEVGADLVC---SHPRLDR 1368
Query: 699 QCLHQNGETLYNSGDTWVQNCQQC 722
Q + LY G+ W +C C
Sbjct: 1369 QATYTECCCLY--GEAWGMDCALC 1390
Score = 67.8 bits (164), Expect = 4e-11
Identities = 38/139 (27%), Positives = 60/139 (43%), Gaps = 5/139 (3%)
Query: 382 SHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSCRDGFRALREDNAYCEDI 441
+ +T CC V +G+ C +++C G+ A D + D+
Sbjct: 1198 ARNVTWQECCCTVGEGWGSGCRIQQCPGTETAEY---QSLCPHGRGYLAPSGDLSLRRDV 1254
Query: 442 DECAEGRHYCRENTMCVNTPGSFMCICKTG-YIRIDDYSCTEHDECITNQHNCDENALCF 500
DEC R ++ +CVNT + C C G Y C ++DEC + C E C
Sbjct: 1255 DECQLFRDQVCKSGVCVNTAPGYSCYCSNGYYYHTQRLECIDNDECADEEPAC-EGGRCV 1313
Query: 501 NTVGGHNCVCKPGYTGNGT 519
NTVG ++C C+P +G+
Sbjct: 1314 NTVGSYHCTCEPPLVLDGS 1332
Score = 63.9 bits (154), Expect = 6e-10
Identities = 49/166 (29%), Positives = 68/166 (40%), Gaps = 26/166 (15%)
Query: 360 ECKDQTMKLVESSGCP--------ALDCPESHQITLSHSCCKV--CKGY--DFCSERHNC 407
EC+++ L S C DC + +C V C+ Y + C +
Sbjct: 964 ECRERGPALCGSQRCENSPGSYRCVRDCDPGYHAGPEGTCDDVDECQEYGPEICGAQR-- 1021
Query: 408 MENSICRNLNDRAVCS--CRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFM 465
C N C+ C G++ C+D+DEC R +C + +C N PGSF
Sbjct: 1022 -----CENTPGSYRCTPACDPGYQPT--PGGGCQDVDEC-RNRSFCGAHAVCQNLPGSFQ 1073
Query: 466 CICKTGYIRI-DDYSCTEHDECITNQHNCDENALCFNTVGGHNCVC 510
C+C GY D C + +EC T Q C ALC N G CVC
Sbjct: 1074 CLCDQGYEGARDGRHCVDVNECETLQGVCGA-ALCENVEGSFLCVC 1118
Score = 48.1 bits (113), Expect = 3e-05
Identities = 26/65 (40%), Positives = 33/65 (50%), Gaps = 3/65 (4%)
Query: 410 NSICRNLNDRAVCSCRDGFRALREDNAYCEDIDEC--AEGRHYCRENTMCVNTPGSFMCI 467
N C + + C C DG+R L C DI+EC AE N C+NT GSF CI
Sbjct: 1545 NGRCVRVPEGFTCRCFDGYR-LDMTRMACVDINECDEAEAASPLCVNARCLNTDGSFRCI 1603
Query: 468 CKTGY 472
C+ G+
Sbjct: 1604 CRPGF 1608
Score = 47.4 bits (111), Expect = 5e-05
Identities = 28/81 (34%), Positives = 37/81 (45%), Gaps = 13/81 (16%)
Query: 438 CEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRID--DYSCTEHDECITNQHNCD- 494
C +D C GR CV P F C C GY R+D +C + +EC +
Sbjct: 1537 CGILDGCTNGR--------CVRVPEGFTCRCFDGY-RLDMTRMACVDINECDEAEAASPL 1587
Query: 495 -ENALCFNTVGGHNCVCKPGY 514
NA C NT G C+C+PG+
Sbjct: 1588 CVNARCLNTDGSFRCICRPGF 1608
Score = 46.2 bits (108), Expect = 1e-04
Identities = 32/117 (27%), Positives = 48/117 (41%), Gaps = 13/117 (11%)
Query: 395 CKGYDFCSERHNCMENSICRNLNDRAVCS---CRDGFRALREDNAYCEDIDECAEGRHYC 451
C+G H+C S ++R C GF + N CED+DECA G C
Sbjct: 312 CRGAGLAWGVHDCQLCSERLGNSERVSAPDGPCPTGFERV---NGSCEDVDECATGGR-C 367
Query: 452 RENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNC 508
+ C NT G + C+C G++ +D + CI+ + CF + C
Sbjct: 368 QHGE-CANTRGGYTCVCPDGFL-LD----SSRSSCISQHVISEAKGPCFRVLRDGGC 418
Score = 43.9 bits (102), Expect = 6e-04
Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 10/87 (11%)
Query: 550 PSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESCEDIDECGTG 609
P E + +EC G + + C+ +P + C C DGY + +C DI+EC
Sbjct: 1528 PYEELEAEEC--GILDGCTNGRCVRVPEGFTCRCFDGYR----LDMTRMACVDINECDEA 1581
Query: 610 RHS---CANDTICFNLDGGYDCRCPHG 633
+ C N C N DG + C C G
Sbjct: 1582 EAASPLCVN-ARCLNTDGSFRCICRPG 1607
Score = 41.6 bits (96), Expect = 0.003
Identities = 38/132 (28%), Positives = 57/132 (43%), Gaps = 27/132 (20%)
Query: 468 CKTGYIRIDDYSCTEHDECITNQHNCDENALCFNTVGGHNCVCKPGY--TGNGTTC---- 521
C TG+ R++ SC + DEC T C ++ C NT GG+ CVC G+ + ++C
Sbjct: 344 CPTGFERVNG-SCEDVDECATGGR-C-QHGECANTRGGYTCVCPDGFLLDSSRSSCISQH 400
Query: 522 -----KAFCKDGCRNGGAC------IAANVCACPQ--GFTGPSCETDIDECSDGFVQCDS 568
K C R+GG I +C C + G C+ S+GF
Sbjct: 401 VISEAKGPCFRVLRDGGCSLPILRNITKQICCCSRVGKAWGRGCQLCPPFGSEGF----- 455
Query: 569 RANCINLPGWYH 580
R C PG+++
Sbjct: 456 REICPAGPGYHY 467
Score = 40.8 bits (94), Expect = 0.005
Identities = 18/35 (51%), Positives = 20/35 (57%), Gaps = 2/35 (5%)
Query: 599 SCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHG 633
SCED+DEC TG + C N GGY C CP G
Sbjct: 354 SCEDVDECATGGRCQHGE--CANTRGGYTCVCPDG 386
Score = 38.9 bits (89), Expect = 0.019
Identities = 34/116 (29%), Positives = 44/116 (37%), Gaps = 22/116 (18%)
Query: 499 CFNTVGGHNCVCK-PGYTGNGTTCKA-----------FCKDGCRNGGACIAANVCACPQG 546
CF + G C PG C+ C + N ++A CP G
Sbjct: 289 CFRELRGGECASPLPGLRTQEVCCRGAGLAWGVHDCQLCSERLGNSER-VSAPDGPCPTG 347
Query: 547 F--TGPSCETDIDECSDGFVQCDSRANCINLPGWYHCECRDGYHDNGMFSPSGESC 600
F SCE D+DEC+ G +C C N G Y C C DG+ + S SC
Sbjct: 348 FERVNGSCE-DVDECATGG-RCQ-HGECANTRGGYTCVCPDGF----LLDSSRSSC 396
Score = 35.0 bits (79), Expect = 0.28
Identities = 23/70 (32%), Positives = 31/70 (44%), Gaps = 11/70 (15%)
Query: 527 DGCRNGGACIAAN---VCACPQGF----TGPSCETDIDECSDGFVQCDS--RANCINLPG 577
DGC NG C+ C C G+ T +C DI+EC + A C+N G
Sbjct: 1541 DGCTNG-RCVRVPEGFTCRCFDGYRLDMTRMAC-VDINECDEAEAASPLCVNARCLNTDG 1598
Query: 578 WYHCECRDGY 587
+ C CR G+
Sbjct: 1599 SFRCICRPGF 1608
Score = 34.3 bits (77), Expect = 0.48
Identities = 11/25 (44%), Positives = 14/25 (56%)
Query: 529 CRNGGACIAANVCACPQGFTGPSCE 553
C NGG C+ + C CP F G C+
Sbjct: 157 CHNGGVCVKPDRCLCPPDFAGKFCQ 181
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.138 0.475
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,641,765
Number of Sequences: 37866
Number of extensions: 2008551
Number of successful extensions: 12882
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 206
Number of HSP's successfully gapped in prelim test: 265
Number of HSP's that attempted gapping in prelim test: 5515
Number of HSP's gapped (non-prelim): 2667
length of query: 816
length of database: 18,247,518
effective HSP length: 111
effective length of query: 705
effective length of database: 14,044,392
effective search space: 9901296360
effective search space used: 9901296360
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.