BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|222136634 tetratricopeptide repeat domain 26 isoform 1 [Homo sapiens] (554 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|222136634 tetratricopeptide repeat domain 26 isoform 1 [Homo ... 1119 0.0 gi|222136607 tetratricopeptide repeat domain 26 isoform 3 [Homo ... 1035 0.0 gi|222136605 tetratricopeptide repeat domain 26 isoform 2 [Homo ... 954 0.0 gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] 42 0.002 gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizi... 34 0.31 gi|70980549 programmed cell death 11 [Homo sapiens] 34 0.40 gi|31317299 inhibitor of DNA binding 1 isoform a [Homo sapiens] 33 0.68 gi|31317297 inhibitor of DNA binding 1 isoform b [Homo sapiens] 33 0.68 gi|225545550 TEL2, telomere maintenance 2, homolog [Homo sapiens] 32 1.2 gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens] 32 1.2 gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens] 32 2.0 gi|4505245 mannose receptor C type 1 precursor [Homo sapiens] 32 2.0 gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sa... 32 2.0 gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sa... 32 2.0 gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sa... 32 2.0 gi|57546917 mannose receptor, C type 1-like 1 [Homo sapiens] 32 2.0 gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens] 32 2.0 gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] 31 2.6 gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 30 4.4 gi|169161714 PREDICTED: tetratricopeptide repeat domain 34 [Homo... 30 4.4 gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo ... 30 4.4 gi|169162130 PREDICTED: tetratricopeptide repeat domain 34 [Homo... 30 4.4 gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Hom... 30 4.4 gi|27262638 sperm associated antigen 1 [Homo sapiens] 30 4.4 gi|27262636 sperm associated antigen 1 [Homo sapiens] 30 4.4 gi|11559925 X-prolyl aminopeptidase (aminopeptidase P) 3, putati... 30 5.8 gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo ... 30 5.8 gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo ... 30 5.8 gi|21361356 translocase of outer mitochondrial membrane 34 [Homo... 30 5.8 gi|166235180 tetratricopeptide repeat domain 22 isoform 1 [Homo ... 30 5.8 >gi|222136634 tetratricopeptide repeat domain 26 isoform 1 [Homo sapiens] Length = 554 Score = 1119 bits (2894), Expect = 0.0 Identities = 554/554 (100%), Positives = 554/554 (100%) Query: 1 MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTN 60 MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTN Sbjct: 1 MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTN 60 Query: 61 LWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKS 120 LWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKS Sbjct: 61 LWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKS 120 Query: 121 RLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLD 180 RLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLD Sbjct: 121 RLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLD 180 Query: 181 NREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEA 240 NREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEA Sbjct: 181 NREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEA 240 Query: 241 ELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDD 300 ELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDD Sbjct: 241 ELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDD 300 Query: 301 VQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIP 360 VQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIP Sbjct: 301 VQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIP 360 Query: 361 GRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQ 420 GRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQ Sbjct: 361 GRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQ 420 Query: 421 SEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYS 480 SEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYS Sbjct: 421 SEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYS 480 Query: 481 AKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLLRSTGNTQVEYMI 540 AKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLLRSTGNTQVEYMI Sbjct: 481 AKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLLRSTGNTQVEYMI 540 Query: 541 RIMKKWAKENRVSI 554 RIMKKWAKENRVSI Sbjct: 541 RIMKKWAKENRVSI 554 >gi|222136607 tetratricopeptide repeat domain 26 isoform 3 [Homo sapiens] Length = 523 Score = 1035 bits (2676), Expect = 0.0 Identities = 523/554 (94%), Positives = 523/554 (94%), Gaps = 31/554 (5%) Query: 1 MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTN 60 MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLE Sbjct: 1 MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLE------------- 47 Query: 61 LWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKS 120 EYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKS Sbjct: 48 ------------------EYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKS 89 Query: 121 RLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLD 180 RLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLD Sbjct: 90 RLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLD 149 Query: 181 NREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEA 240 NREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEA Sbjct: 150 NREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEA 209 Query: 241 ELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDD 300 ELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDD Sbjct: 210 ELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDD 269 Query: 301 VQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIP 360 VQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIP Sbjct: 270 VQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIP 329 Query: 361 GRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQ 420 GRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQ Sbjct: 330 GRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQ 389 Query: 421 SEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYS 480 SEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYS Sbjct: 390 SEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYKMGQFYYS 449 Query: 481 AKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLLRSTGNTQVEYMI 540 AKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLLRSTGNTQVEYMI Sbjct: 450 AKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLLRSTGNTQVEYMI 509 Query: 541 RIMKKWAKENRVSI 554 RIMKKWAKENRVSI Sbjct: 510 RIMKKWAKENRVSI 523 >gi|222136605 tetratricopeptide repeat domain 26 isoform 2 [Homo sapiens] Length = 487 Score = 954 bits (2467), Expect = 0.0 Identities = 473/473 (100%), Positives = 473/473 (100%) Query: 1 MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTN 60 MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTN Sbjct: 1 MMLSRAKPAVGRGVQHTDKRKKKGRKIPKLEELLSKRDFTGAITLLEFKRHVGEEEEDTN 60 Query: 61 LWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKS 120 LWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKS Sbjct: 61 LWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKS 120 Query: 121 RLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLD 180 RLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLD Sbjct: 121 RLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLD 180 Query: 181 NREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEA 240 NREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEA Sbjct: 181 NREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYNGRAAEA 240 Query: 241 ELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDD 300 ELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDD Sbjct: 241 ELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDD 300 Query: 301 VQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIP 360 VQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIP Sbjct: 301 VQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTIP 360 Query: 361 GRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQ 420 GRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQ Sbjct: 361 GRQCMASCFFLLKQFDDVLIYLNSFKSYFYNDDIFNFNYAQAKAATGNTSEGEEAFLLIQ 420 Query: 421 SEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYK 473 SEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYK Sbjct: 421 SEKMKNDYIYLSWLARCYIMNKKPRLAWELYLKMETSGESFSLLQLIANDCYK 473 >gi|25952122 Bardet-Biedl syndrome 4 [Homo sapiens] Length = 519 Score = 41.6 bits (96), Expect = 0.002 Identities = 39/155 (25%), Positives = 63/155 (40%), Gaps = 27/155 (17%) Query: 68 FHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNRLL 127 F LG +K A+E Y A K + E+ NL Y +L + +A+ +L N L Sbjct: 112 FLLGKHKAAIEVYNEAAKLNQKDWEISHNLGVCYIYLKQFNKAQ--------DQLHNAL- 162 Query: 128 FHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLAL 187 + N D+T + L IH + +AI++YK+ + + E L Sbjct: 163 ----------------NLNRHDLT--YIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTEL 204 Query: 188 NVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIAL 222 + L Y +L Y + E L L P + A+ Sbjct: 205 LTTLGLLYLQLGIYQKAFEHLGNALTYDPTNYKAI 239 Score = 30.4 bits (67), Expect = 4.4 Identities = 16/52 (30%), Positives = 27/52 (51%) Query: 59 TNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQA 110 T + +G GD +A+E Y+ A + N+E+ L Y LG+Y++A Sbjct: 170 TYIMLGKIHLLEGDLDKAIEVYKKAVEFSPENTELLTTLGLLYLQLGIYQKA 221 >gi|5803181 stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing protein) [Homo sapiens] Length = 543 Score = 34.3 bits (77), Expect = 0.31 Identities = 29/138 (21%), Positives = 56/138 (40%), Gaps = 24/138 (17%) Query: 45 LLEFKRHVGEEEEDTNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFL 104 L E K+ +E+E +G A+ D+ AL+ Y+ A + + N N A YF Sbjct: 218 LPENKKQALKEKE-----LGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEK 272 Query: 105 GMYKQAEAAGFKASKSRLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMR 164 G Y + KA + +NR ++ + + + + + ++ Sbjct: 273 GDYNKCRELCEKAIEVGRENR-------------------EDYRQIAKAYARIGNSYFKE 313 Query: 165 SHYQEAIDIYKRILLDNR 182 Y++AI Y + L ++R Sbjct: 314 EKYKDAIHFYNKSLAEHR 331 >gi|70980549 programmed cell death 11 [Homo sapiens] Length = 1871 Score = 33.9 bits (76), Expect = 0.40 Identities = 57/276 (20%), Positives = 108/276 (39%), Gaps = 40/276 (14%) Query: 47 EFKRHVGEEEEDTNLWIGYCAFHLG--DYKRALEEYENATK-----EENCNSEVWVNLAC 99 +F R V + LW+ Y AFHL + ++A E A K EE VWV L Sbjct: 1607 DFDRLVLSSPNSSILWLQYMAFHLQATEIEKARAVAERALKTISFREEQEKLNVWVALLN 1666 Query: 100 TYFFLGMYKQAEAAGFKASKSRLQNRLLFHLAHKFNDEKKLMSFHQNLQDVTEDQLSLAS 159 MY E+ +F A ++N+ K+ L LA Sbjct: 1667 LE---NMYGSQESL-----------TKVFERAVQYNEPLKVF-------------LHLAD 1699 Query: 160 IHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDST 219 I+ +QEA ++Y R+L R+ A+ + + S VL L+ +P Sbjct: 1700 IYAKSEKFQEAGELYNRMLKRFRQEKAVWIKYGAFLLRRSQAAASHRVLQRALECLPSKE 1759 Query: 220 IALNLKACNHFRLYNGRAAEAE-LKSLMDNASSSFEFAKEL--IRHNLVVFRGGEGALQV 276 ++ F + +AE K++ +N S++ ++ + ++ + G + ++ Sbjct: 1760 ---HVDVIAKFAQLEFQLGDAERAKAIFENTLSTYPKRTDVWSVYIDMTIKHGSQKDVRD 1816 Query: 277 LPPLVDVIPEARLNLVIYYLRQDDVQEAYNLIKDLE 312 + V + A + ++ R D ++ + KD++ Sbjct: 1817 IFERVIHLSLAPKRMKFFFKRYLDYEKQHGTEKDVQ 1852 >gi|31317299 inhibitor of DNA binding 1 isoform a [Homo sapiens] Length = 155 Score = 33.1 bits (74), Expect = 0.68 Identities = 22/69 (31%), Positives = 37/69 (53%), Gaps = 8/69 (11%) Query: 249 ASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLI 308 AS + E + L ++ + R GA LP L+D E ++N+++Y D+ Y+ + Sbjct: 25 ASGAGEVVRCLSEQSVAISRCAGGAGARLPALLD---EQQVNVLLY-----DMNGCYSRL 76 Query: 309 KDLEPTTPQ 317 K+L PT PQ Sbjct: 77 KELVPTLPQ 85 >gi|31317297 inhibitor of DNA binding 1 isoform b [Homo sapiens] Length = 149 Score = 33.1 bits (74), Expect = 0.68 Identities = 22/69 (31%), Positives = 37/69 (53%), Gaps = 8/69 (11%) Query: 249 ASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVIPEARLNLVIYYLRQDDVQEAYNLI 308 AS + E + L ++ + R GA LP L+D E ++N+++Y D+ Y+ + Sbjct: 25 ASGAGEVVRCLSEQSVAISRCAGGAGARLPALLD---EQQVNVLLY-----DMNGCYSRL 76 Query: 309 KDLEPTTPQ 317 K+L PT PQ Sbjct: 77 KELVPTLPQ 85 >gi|225545550 TEL2, telomere maintenance 2, homolog [Homo sapiens] Length = 837 Score = 32.3 bits (72), Expect = 1.2 Identities = 34/112 (30%), Positives = 51/112 (45%), Gaps = 14/112 (12%) Query: 228 NHFRLYNG---RAAEAELKSLMDNASSSFEFAKELIRHNLVVFRGGEGALQVLPPLVDVI 284 N+FRL R +A + SL SS F +++ V R E L VL P + + Sbjct: 183 NYFRLLGEEVVRVLQAVVDSLQGGLDSSVSFVSQVLGKACVHGRQQE-ILGVLVPRLAAL 241 Query: 285 PEARLNLVIYYLRQDDVQEAYNLIKDLEPTTPQEYILKGVVNAALGQEMGSR 336 + YL Q + + L++ + P E +L G+V AALG E+ SR Sbjct: 242 TQGS------YLHQ---RVCWRLVEQV-PDRAMEAVLTGLVEAALGPEVLSR 283 >gi|60685231 tetratricopeptide repeat domain 7B [Homo sapiens] Length = 843 Score = 32.3 bits (72), Expect = 1.2 Identities = 20/73 (27%), Positives = 37/73 (50%), Gaps = 6/73 (8%) Query: 152 EDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVY 211 E L +A ++Y+ Y+EA++IY R+ LD+ A+ Y+L + + Sbjct: 98 ESNLIMAKLNYVEGDYKEALNIYARVGLDDLPLTAVPP------YRLRVIAEAYATKGLC 151 Query: 212 LQQIPDSTIALNL 224 L+++P S+ NL Sbjct: 152 LEKLPISSSTSNL 164 >gi|229577238 tetratricopeptide repeat domain 18 [Homo sapiens] Length = 1121 Score = 31.6 bits (70), Expect = 2.0 Identities = 21/78 (26%), Positives = 32/78 (41%) Query: 59 TNLWIGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKAS 118 T L +G + L + A + A N N+EVW LA +G +AE A Sbjct: 1035 TWLGLGIACYRLEELTEAEDALSEANALNNYNAEVWAYLALVCLKVGRQLEAEQAYKYMI 1094 Query: 119 KSRLQNRLLFHLAHKFND 136 K +L++ L H + Sbjct: 1095 KLKLKDEALLAEIHTLQE 1112 >gi|4505245 mannose receptor C type 1 precursor [Homo sapiens] Length = 1456 Score = 31.6 bits (70), Expect = 2.0 Identities = 16/59 (27%), Positives = 28/59 (47%) Query: 473 KMGQFYYSAKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLLRST 531 K G +YS K F + ++ + W+ R AC+G +++ + KE H+ ST Sbjct: 946 KEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDST 1004 >gi|53759120 tetratricopeptide repeat domain 8 isoform A [Homo sapiens] Length = 515 Score = 31.6 bits (70), Expect = 2.0 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 5/75 (6%) Query: 43 ITLLEFKRHVG---EEEEDTNLW--IGYCAFHLGDYKRALEEYENATKEENCNSEVWVNL 97 +TL F+R + EEE ++W +G+ A +GD A + + A N ++E + NL Sbjct: 378 MTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNL 437 Query: 98 ACTYFFLGMYKQAEA 112 A G +QA A Sbjct: 438 AVLEMRKGHVEQARA 452 Score = 30.8 bits (68), Expect = 3.4 Identities = 34/153 (22%), Positives = 61/153 (39%), Gaps = 22/153 (14%) Query: 117 ASKSRLQNRLLFHLAHKFNDEKKLMSF------HQNLQDVTEDQLSLASIHYMRSHYQEA 170 + K +L L ++ H ND K + H +D ++ + +Y Y+EA Sbjct: 186 SQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWW-KVQIGKCYYRLGMYREA 244 Query: 171 IDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHF 230 +K L +E + +Y+A Y LD + + L + P L C Sbjct: 245 EKQFKSAL-KQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLL----CGIA 299 Query: 231 RLYNGRAAEAELKSLMDNASSSFEFAKELIRHN 263 R+Y M+N SS+ E+ KE+++ + Sbjct: 300 RIYEE----------MNNMSSAAEYYKEVLKQD 322 Score = 30.8 bits (68), Expect = 3.4 Identities = 37/172 (21%), Positives = 65/172 (37%), Gaps = 9/172 (5%) Query: 65 YCAFHLGDYKRALEEYENATKEENCNSEVW-VNLACTYFFLGMYKQAEAAGFKASKSRLQ 123 Y H D K AL+ +T+ W V + Y+ LGMY++AE A K + Sbjct: 198 YIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEM 257 Query: 124 NRLLFHLAHKF----NDEKKLMSFHQNLQDVTED---QLSLASIHYMRSHYQEAIDIYKR 176 +LA + L F Q L + +A I+ ++ A + YK Sbjct: 258 VDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKE 317 Query: 177 ILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQ-IPDSTIALNLKAC 227 +L + ++ + ++ D +++ LQ I + + NL C Sbjct: 318 VLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLC 369 >gi|38146008 tetratricopeptide repeat domain 8 isoform C [Homo sapiens] Length = 475 Score = 31.6 bits (70), Expect = 2.0 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 5/75 (6%) Query: 43 ITLLEFKRHVG---EEEEDTNLW--IGYCAFHLGDYKRALEEYENATKEENCNSEVWVNL 97 +TL F+R + EEE ++W +G+ A +GD A + + A N ++E + NL Sbjct: 338 MTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNL 397 Query: 98 ACTYFFLGMYKQAEA 112 A G +QA A Sbjct: 398 AVLEMRKGHVEQARA 412 Score = 30.8 bits (68), Expect = 3.4 Identities = 37/172 (21%), Positives = 65/172 (37%), Gaps = 9/172 (5%) Query: 65 YCAFHLGDYKRALEEYENATKEENCNSEVW-VNLACTYFFLGMYKQAEAAGFKASKSRLQ 123 Y H D K AL+ +T+ W V + Y+ LGMY++AE A K + Sbjct: 158 YIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEM 217 Query: 124 NRLLFHLAHKF----NDEKKLMSFHQNLQDVTED---QLSLASIHYMRSHYQEAIDIYKR 176 +LA + L F Q L + +A I+ ++ A + YK Sbjct: 218 VDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKE 277 Query: 177 ILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQ-IPDSTIALNLKAC 227 +L + ++ + ++ D +++ LQ I + + NL C Sbjct: 278 VLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLC 329 Score = 29.6 bits (65), Expect = 7.6 Identities = 34/149 (22%), Positives = 59/149 (39%), Gaps = 22/149 (14%) Query: 121 RLQNRLLFHLAHKFNDEKKLMSF------HQNLQDVTEDQLSLASIHYMRSHYQEAIDIY 174 RL L ++ H ND K + H +D ++ + +Y Y+EA + Sbjct: 150 RLGTALFEYIFHHENDVKTALDLAALSTEHSQYKDWWW-KVQIGKCYYRLGMYREAEKQF 208 Query: 175 KRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHFRLYN 234 K L +E + +Y+A Y LD + + L + P L C R+Y Sbjct: 209 KSAL-KQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLL----CGIARIYE 263 Query: 235 GRAAEAELKSLMDNASSSFEFAKELIRHN 263 M+N SS+ E+ KE+++ + Sbjct: 264 E----------MNNMSSAAEYYKEVLKQD 282 >gi|38146012 tetratricopeptide repeat domain 8 isoform B [Homo sapiens] Length = 505 Score = 31.6 bits (70), Expect = 2.0 Identities = 23/75 (30%), Positives = 37/75 (49%), Gaps = 5/75 (6%) Query: 43 ITLLEFKRHVG---EEEEDTNLW--IGYCAFHLGDYKRALEEYENATKEENCNSEVWVNL 97 +TL F+R + EEE ++W +G+ A +GD A + + A N ++E + NL Sbjct: 368 MTLTSFERALSLAENEEEAADVWYNLGHVAVGIGDTNLAHQCFRLALVNNNNHAEAYNNL 427 Query: 98 ACTYFFLGMYKQAEA 112 A G +QA A Sbjct: 428 AVLEMRKGHVEQARA 442 Score = 30.8 bits (68), Expect = 3.4 Identities = 34/153 (22%), Positives = 61/153 (39%), Gaps = 22/153 (14%) Query: 117 ASKSRLQNRLLFHLAHKFNDEKKLMSF------HQNLQDVTEDQLSLASIHYMRSHYQEA 170 + K +L L ++ H ND K + H +D ++ + +Y Y+EA Sbjct: 176 SQKPKLAKALFEYIFHHENDVKTALDLAALSTEHSQYKDWWW-KVQIGKCYYRLGMYREA 234 Query: 171 IDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKACNHF 230 +K L +E + +Y+A Y LD + + L + P L C Sbjct: 235 EKQFKSAL-KQQEMVDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLL----CGIA 289 Query: 231 RLYNGRAAEAELKSLMDNASSSFEFAKELIRHN 263 R+Y M+N SS+ E+ KE+++ + Sbjct: 290 RIYEE----------MNNMSSAAEYYKEVLKQD 312 Score = 30.8 bits (68), Expect = 3.4 Identities = 37/172 (21%), Positives = 65/172 (37%), Gaps = 9/172 (5%) Query: 65 YCAFHLGDYKRALEEYENATKEENCNSEVW-VNLACTYFFLGMYKQAEAAGFKASKSRLQ 123 Y H D K AL+ +T+ W V + Y+ LGMY++AE A K + Sbjct: 188 YIFHHENDVKTALDLAALSTEHSQYKDWWWKVQIGKCYYRLGMYREAEKQFKSALKQQEM 247 Query: 124 NRLLFHLAHKF----NDEKKLMSFHQNLQDVTED---QLSLASIHYMRSHYQEAIDIYKR 176 +LA + L F Q L + +A I+ ++ A + YK Sbjct: 248 VDTFLYLAKVYVSLDQPVTALNLFKQGLDKFPGEVTLLCGIARIYEEMNNMSSAAEYYKE 307 Query: 177 ILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQ-IPDSTIALNLKAC 227 +L + ++ + ++ D +++ LQ I + + NL C Sbjct: 308 VLKQDNTHVEAIACIGSNHFYSDQPEIALRFYRRLLQMGIYNGQLFNNLGLC 359 >gi|57546917 mannose receptor, C type 1-like 1 [Homo sapiens] Length = 1456 Score = 31.6 bits (70), Expect = 2.0 Identities = 16/59 (27%), Positives = 28/59 (47%) Query: 473 KMGQFYYSAKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLLRST 531 K G +YS K F + ++ + W+ R AC+G +++ + KE H+ ST Sbjct: 946 KEGWNFYSNKCFKIFGFMEEERKNWQEARKACIGFGGNLVSIQNEKEQAFLTYHMKDST 1004 >gi|116089292 tetratricopeptide repeat domain 21B [Homo sapiens] Length = 1316 Score = 31.6 bits (70), Expect = 2.0 Identities = 23/75 (30%), Positives = 39/75 (52%), Gaps = 4/75 (5%) Query: 301 VQEAYNLIKDLEPTTPQEYI-LKGVVNAALGQEMGSRDHMKIAQQFFQLVGGSASECDTI 359 V+ A L+K+L+P T Q ++ L+ + N L M ++ + Q +ASE + I Sbjct: 1101 VRTAEKLLKELKPQTVQGHVQLRIMENYCL---MATKQKSNVEQALNTFTEIAASEKEHI 1157 Query: 360 PGRQCMASCFFLLKQ 374 P MA+ + +LKQ Sbjct: 1158 PALLGMATAYMILKQ 1172 Score = 29.6 bits (65), Expect = 7.6 Identities = 38/155 (24%), Positives = 64/155 (41%), Gaps = 11/155 (7%) Query: 71 GDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNRLLFHL 130 GD +RAL +N T E+ E +A Y K F+ R+ N F L Sbjct: 668 GDIERALSILQNVTAEQPYFIEAREKMADIYLKHRKDKMLYITCFREIAERMANPRSFLL 727 Query: 131 -----AHKFNDEKKLMSFHQNLQDVTEDQLSLASI--HYMRSH-YQEAIDIYKRIL-LDN 181 + E+ ++++ Q L +D + + +++H Y AI Y+ L Sbjct: 728 LGDAYMNILEPEEAIVAYEQALNQNPKDGTLASKMGKALIKTHNYSMAITYYEAALKTGQ 787 Query: 182 REYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIP 216 + YL + +A KL +YD +++VL L P Sbjct: 788 KNYLCYD--LAELLLKLKWYDKAEKVLQHALAHEP 820 >gi|7662078 tetratricopeptide repeat domain 37 [Homo sapiens] Length = 1564 Score = 31.2 bits (69), Expect = 2.6 Identities = 31/146 (21%), Positives = 56/146 (38%), Gaps = 16/146 (10%) Query: 72 DYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNRL----- 126 +YK AL+ + K+E N WV + L QA++A KA++ L Sbjct: 21 EYKEALKHCKTVLKQEKNNYNAWVFIGVAAAELEQPDQAQSAYKKAAELEPDQLLAWQGL 80 Query: 127 --LFHLAHKFNDEKKLMSFHQNLQDVTEDQ---------LSLASIHYMRSHYQEAIDIYK 175 L+ + N + L +Q L D+ E L ++Y + E + Sbjct: 81 ANLYEKYNHINAKDDLPGVYQKLLDLYESVDKQKWCDVCKKLVDLYYQEKKHLEVARTWH 140 Query: 176 RILLDNREYLALNVYVALCYYKLDYY 201 +++ +E A N + + KL + Sbjct: 141 KLIKTRQEQGAENEELHQLWRKLTQF 166 >gi|239756104 PREDICTED: tetratricopeptide repeat domain 6 [Homo sapiens] Length = 1614 Score = 30.4 bits (67), Expect = 4.4 Identities = 33/158 (20%), Positives = 61/158 (38%), Gaps = 28/158 (17%) Query: 70 LGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNR-LLF 128 +G + A+++Y++A S + N YF + QA KA K +N +L Sbjct: 1455 MGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM 1514 Query: 129 HLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALN 188 + A KK ++ +V E A++++ R+H+ Sbjct: 1515 NRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHF--------------------- 1553 Query: 189 VYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKA 226 YY L Y++++E L L P+ + N +A Sbjct: 1554 ------YYCLKQYELAEEDLNKALSLKPNDALVYNFRA 1585 >gi|169161714 PREDICTED: tetratricopeptide repeat domain 34 [Homo sapiens] Length = 747 Score = 30.4 bits (67), Expect = 4.4 Identities = 9/23 (39%), Positives = 17/23 (73%) Query: 64 GYCAFHLGDYKRALEEYENATKE 86 G+CA H GD +RA+E+++ ++ Sbjct: 422 GFCALHAGDSRRAMEDFQTVVEQ 444 >gi|239750633 PREDICTED: tetratricopeptide repeat domain 6 [Homo sapiens] Length = 1614 Score = 30.4 bits (67), Expect = 4.4 Identities = 33/158 (20%), Positives = 61/158 (38%), Gaps = 28/158 (17%) Query: 70 LGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNR-LLF 128 +G + A+++Y++A S + N YF + QA KA K +N +L Sbjct: 1455 MGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM 1514 Query: 129 HLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALN 188 + A KK ++ +V E A++++ R+H+ Sbjct: 1515 NRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHF--------------------- 1553 Query: 189 VYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKA 226 YY L Y++++E L L P+ + N +A Sbjct: 1554 ------YYCLKQYELAEEDLNKALSLKPNDALVYNFRA 1585 >gi|169162130 PREDICTED: tetratricopeptide repeat domain 34 [Homo sapiens] Length = 901 Score = 30.4 bits (67), Expect = 4.4 Identities = 9/23 (39%), Positives = 17/23 (73%) Query: 64 GYCAFHLGDYKRALEEYENATKE 86 G+CA H GD +RA+E+++ ++ Sbjct: 576 GFCALHAGDSRRAMEDFQTVVEQ 598 >gi|239744942 PREDICTED: chromosome 14 open reading frame 25 [Homo sapiens] Length = 1614 Score = 30.4 bits (67), Expect = 4.4 Identities = 33/158 (20%), Positives = 61/158 (38%), Gaps = 28/158 (17%) Query: 70 LGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNR-LLF 128 +G + A+++Y++A S + N YF + QA KA K +N +L Sbjct: 1455 MGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLM 1514 Query: 129 HLAHKFNDEKKLMSFHQNLQDVTEDQLSLASIHYMRSHYQEAIDIYKRILLDNREYLALN 188 + A KK ++ +V E A++++ R+H+ Sbjct: 1515 NRAITNTILKKYEEAKEDFANVIESCPFWAAVYFNRAHF--------------------- 1553 Query: 189 VYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLKA 226 YY L Y++++E L L P+ + N +A Sbjct: 1554 ------YYCLKQYELAEEDLNKALSLKPNDALVYNFRA 1585 >gi|27262638 sperm associated antigen 1 [Homo sapiens] Length = 926 Score = 30.4 bits (67), Expect = 4.4 Identities = 24/94 (25%), Positives = 42/94 (44%) Query: 166 HYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLK 225 +Y++A+ Y L N + A+ ALCY KL ++ +++ LQ + A + Sbjct: 638 NYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRR 697 Query: 226 ACNHFRLYNGRAAEAELKSLMDNASSSFEFAKEL 259 A H L N + + +L ++ S E EL Sbjct: 698 ALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMEL 731 >gi|27262636 sperm associated antigen 1 [Homo sapiens] Length = 926 Score = 30.4 bits (67), Expect = 4.4 Identities = 24/94 (25%), Positives = 42/94 (44%) Query: 166 HYQEAIDIYKRILLDNREYLALNVYVALCYYKLDYYDVSQEVLAVYLQQIPDSTIALNLK 225 +Y++A+ Y L N + A+ ALCY KL ++ +++ LQ + A + Sbjct: 638 NYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLADGNVKAFYRR 697 Query: 226 ACNHFRLYNGRAAEAELKSLMDNASSSFEFAKEL 259 A H L N + + +L ++ S E EL Sbjct: 698 ALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMEL 731 >gi|11559925 X-prolyl aminopeptidase (aminopeptidase P) 3, putative [Homo sapiens] Length = 507 Score = 30.0 bits (66), Expect = 5.8 Identities = 18/49 (36%), Positives = 24/49 (48%), Gaps = 2/49 (4%) Query: 480 SAKAFDVLERLDPNPEYWEGKRGACVGIFQMIIAGREPKETLREVLHLL 528 S KA + R DP+ E W+G R G + + G + TL E HLL Sbjct: 146 SHKAILFVPRRDPSRELWDGPRSGTDG--AIALTGVDEAYTLEEFQHLL 192 >gi|28558993 intraflagellar transport 88 homolog isoform 1 [Homo sapiens] Length = 833 Score = 30.0 bits (66), Expect = 5.8 Identities = 15/47 (31%), Positives = 24/47 (51%) Query: 64 GYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQA 110 G F GDY++A E Y+ A + ++ +E N+ TY L +A Sbjct: 500 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEA 546 >gi|28329439 intraflagellar transport 88 homolog isoform 2 [Homo sapiens] Length = 824 Score = 30.0 bits (66), Expect = 5.8 Identities = 15/47 (31%), Positives = 24/47 (51%) Query: 64 GYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQA 110 G F GDY++A E Y+ A + ++ +E N+ TY L +A Sbjct: 491 GNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEA 537 >gi|21361356 translocase of outer mitochondrial membrane 34 [Homo sapiens] Length = 309 Score = 30.0 bits (66), Expect = 5.8 Identities = 20/81 (24%), Positives = 36/81 (44%), Gaps = 2/81 (2%) Query: 71 GDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEAAGFKASKSRLQNRLLFHL 130 G++K+A+E+Y + N S + N A Y L Y +A +A K +N F+ Sbjct: 207 GNHKKAIEKYSESLLCSNLESATYSNRALCYLVLKQYTEAVKDCTEALKLDGKNVKAFY- 265 Query: 131 AHKFNDEKKLMSFHQNLQDVT 151 + K L + + D++ Sbjct: 266 -RRAQAHKALKDYKSSFADIS 285 >gi|166235180 tetratricopeptide repeat domain 22 isoform 1 [Homo sapiens] Length = 569 Score = 30.0 bits (66), Expect = 5.8 Identities = 17/50 (34%), Positives = 23/50 (46%) Query: 63 IGYCAFHLGDYKRALEEYENATKEENCNSEVWVNLACTYFFLGMYKQAEA 112 +G AF+L + A E + E N W NLA Y LG ++ EA Sbjct: 72 LGAFAFYLEELDEARECFLEVAHEHPGNLNAWANLAHVYGRLGQEEEEEA 121 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.321 0.136 0.402 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 19,997,394 Number of Sequences: 37866 Number of extensions: 855528 Number of successful extensions: 2053 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 19 Number of HSP's successfully gapped in prelim test: 19 Number of HSP's that attempted gapping in prelim test: 1998 Number of HSP's gapped (non-prelim): 66 length of query: 554 length of database: 18,247,518 effective HSP length: 107 effective length of query: 447 effective length of database: 14,195,856 effective search space: 6345547632 effective search space used: 6345547632 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.