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Search of human proteins with 222136583
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo
sapiens]
(1258 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sap... 2544 0.0
gi|40254823 SH2 containing inositol phosphatase isoform b [Homo ... 831 0.0
gi|64085167 SH2 containing inositol phosphatase isoform a [Homo ... 828 0.0
gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase iso... 167 6e-41
gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase iso... 167 6e-41
gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precurs... 161 4e-39
gi|237757312 synaptojanin 1 isoform c [Homo sapiens] 158 3e-38
gi|237757326 synaptojanin 1 isoform d [Homo sapiens] 157 8e-38
gi|237757310 synaptojanin 1 isoform a [Homo sapiens] 154 7e-37
gi|237757308 synaptojanin 1 isoform b [Homo sapiens] 154 7e-37
gi|26190608 synaptojanin 2 [Homo sapiens] 153 9e-37
gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens] 137 6e-32
gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Ho... 119 1e-26
gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatas... 109 1e-23
gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [H... 103 1e-21
gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Ho... 103 1e-21
gi|54792745 SH2 domain containing 1B [Homo sapiens] 89 3e-17
gi|169234945 SH2 domain protein 1A isoform 2 [Homo sapiens] 86 2e-16
gi|4506923 SH2 domain protein 1A isoform 1 [Homo sapiens] 86 2e-16
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 75 3e-13
gi|116284398 WAS/WASL interacting protein family, member 1 [Homo... 75 3e-13
gi|38373695 WAS/WASL interacting protein family, member 1 [Homo ... 75 3e-13
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 75 5e-13
gi|163965366 nascent polypeptide-associated complex alpha subuni... 75 5e-13
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens] 73 1e-12
gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1 pre... 73 2e-12
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 71 6e-12
gi|18959210 WIRE protein [Homo sapiens] 70 1e-11
gi|7706501 WW domain binding protein 11 [Homo sapiens] 69 3e-11
gi|160707881 formin 2 [Homo sapiens] 69 4e-11
>gi|222136583 inositol polyphosphate phosphatase-like 1 [Homo sapiens]
Length = 1258
Score = 2544 bits (6594), Expect = 0.0
Identities = 1258/1258 (100%), Positives = 1258/1258 (100%)
Query: 1 MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV 60
MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV
Sbjct: 1 MASACGAPGPGGALGSQAPSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCV 60
Query: 61 LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE 120
LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE
Sbjct: 61 LYQKHVHTYRILPDGEDFLAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGE 120
Query: 121 REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST 180
REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST
Sbjct: 121 REPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLST 180
Query: 181 VSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS 240
VSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS
Sbjct: 181 VSHDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS 240
Query: 241 SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS 300
SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS
Sbjct: 241 SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS 300
Query: 301 TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT 360
TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT
Sbjct: 301 TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT 360
Query: 361 HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE 420
HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE
Sbjct: 361 HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE 420
Query: 421 PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE 480
PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE
Sbjct: 421 PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE 480
Query: 481 WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN 540
WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN
Sbjct: 481 WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN 540
Query: 541 KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT 600
KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT
Sbjct: 541 KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT 600
Query: 601 HLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT 660
HLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT
Sbjct: 601 HLFWFGDLNYRLDMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPT 660
Query: 661 YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSP 720
YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSP
Sbjct: 661 YRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSP 720
Query: 721 VFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKS 780
VFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKS
Sbjct: 721 VFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYKKS 780
Query: 781 FENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVA 840
FENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVA
Sbjct: 781 FENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECVVA 840
Query: 841 LKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKS 900
LKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKS
Sbjct: 841 LKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGAKS 900
Query: 901 KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPR 960
KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPR
Sbjct: 901 KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPR 960
Query: 961 LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT 1020
LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT
Sbjct: 961 LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT 1020
Query: 1021 VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGR 1080
VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGR
Sbjct: 1021 VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGR 1080
Query: 1081 GGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGP 1140
GGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGP
Sbjct: 1081 GGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGP 1140
Query: 1141 ARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAG 1200
ARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAG
Sbjct: 1141 ARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRASGLGEAG 1200
Query: 1201 MSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK 1258
MSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK
Sbjct: 1201 MSAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLDTLQLSK 1258
>gi|40254823 SH2 containing inositol phosphatase isoform b [Homo
sapiens]
Length = 1188
Score = 831 bits (2146), Expect = 0.0
Identities = 488/1128 (43%), Positives = 665/1128 (58%), Gaps = 91/1128 (8%)
Query: 19 PSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDF 78
P W H +++R+ AEELL+R G+DGSFLVR SES++ A+ALCVLY+ V+TYRILP+ +D
Sbjct: 3 PCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDK 62
Query: 79 LAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGEREPDPPDDRDASDGEDEK 138
VQ S+GV +R F L +LI Y + N GLV L PV E E D + ++
Sbjct: 63 FTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTESVVSP 122
Query: 139 PPLPPRSGSTSISAPTGPSSPLP-----APETPTAPAAESAPNGLSTVS----------- 182
P LPPR+ + S+ P A ET +E+ L ++
Sbjct: 123 PELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEHLKA 182
Query: 183 -HDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQSS 241
DYL D E V+ G+S LPHL + C+ L+ EV + L LE L ++FDQQ S
Sbjct: 183 IQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQQLS 242
Query: 242 PMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPST 301
P L + +P GE ++V KLS L LS I+ K +KAL +P P
Sbjct: 243 P---GLRPRPQVP--GEANPINMVSKLSQLTSLLSSIEDK-VKALLHEGPESPHRPS--- 293
Query: 302 RKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFTH 361
IP FEVK + +G QK L VDVE G+L++ ++ +D ED ++H
Sbjct: 294 ----LIPPVTFEVKAE-------SLGIPQKMQLKVDVESGKLII-KKSKDGSED-KFYSH 340
Query: 362 DRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDEP 421
+I QLIKSQ+ NKL ++ E EK++ RK+++F ++KRE FCQLLQ MKNKHS+Q EP
Sbjct: 341 KKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPEP 400
Query: 422 DMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDREW 481
DMI++FIGTWNMG+ PPPK +TSWF SKG GKT D+ IPHDIYV GTQE+ + ++EW
Sbjct: 401 DMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKEW 460
Query: 482 LDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNK 541
L++L+ L+E+T + ++ +A+ +LWNI++ VL KPEHENRISH+ T +VKTGIANTLGNK
Sbjct: 461 LEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGNK 520
Query: 542 GAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFTH 601
GAVGVSFMFNGTS GFVN HLTSG+EK RRNQNY++ILR L+LGD++L+ F+I+ RFTH
Sbjct: 521 GAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFTH 580
Query: 602 LFWFGDLNYRLDM---DIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFP 658
LFWFGDLNYR+D+ + + I+ I ++++ LL DQL ER + KVFL F EEEI+F
Sbjct: 581 LFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITFA 640
Query: 659 PTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDH 718
PTYR+ER +RD YA+ KQK TG++ N+PSWCDR+LWKSYP H++C SYG T DI+TSDH
Sbjct: 641 PTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSDH 700
Query: 719 SPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYK 778
SPVF TFE GVTSQF+SK G Q IEF A +KT S+TKF++EF+S+CLE +
Sbjct: 701 SPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESFV 760
Query: 779 KSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGECV 838
KS E + + L V++ LP LKPI++D EYL DQH+L+++KS D ESYGE
Sbjct: 761 KSQEGENEEGSE-GELVVKF-GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEGC 818
Query: 839 VALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAGA 898
+AL+ T T L+H GE TG+ +G +K++ T + TRE+LY+++ ++DE+
Sbjct: 819 IALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQ--TSQGKTREKLYDFVKTERDESSG 876
Query: 899 KSKAPSVSRGSQEPRS----GSRKPAFTEASCPLSRLFEEPEKPPPTGRPP-APPRAAPR 953
S++ S +P SR P + +S E P G P PP
Sbjct: 877 PKTLKSLT--SHDPMKQWEVTSRAPPCSGSS------ITEIINPNYMGVGPFGPPMPLHV 928
Query: 954 EEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSAT 1013
++ L+P +P + PPK+S P G P +PP + +PS
Sbjct: 929 KQTLSPDQQPTAWSYDQ-----PPKDSPLGPC----RGESPPTPPGQPPISPKKFLPSTA 979
Query: 1014 KNKVAITVPAPQLGHHRHPRVGEGSSSD--EESGGTLPPPDFP--PPPLPDSAIFLPPSL 1069
+ PR E SD + +G TLP D P P + ++ ++ SL
Sbjct: 980 NRGLP-------------PRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLY--GSL 1024
Query: 1070 DPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGD 1117
P P R + P P+ P P PG S L + D
Sbjct: 1025 SSFPKPAPR----KDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEAD 1068
>gi|64085167 SH2 containing inositol phosphatase isoform a [Homo
sapiens]
Length = 1189
Score = 828 bits (2140), Expect = 0.0
Identities = 489/1129 (43%), Positives = 665/1129 (58%), Gaps = 92/1129 (8%)
Query: 19 PSWYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDF 78
P W H +++R+ AEELL+R G+DGSFLVR SES++ A+ALCVLY+ V+TYRILP+ +D
Sbjct: 3 PCWNHGNITRSKAEELLSRTGKDGSFLVRASESISRAYALCVLYRNCVYTYRILPNEDDK 62
Query: 79 LAVQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVEGEREPDPPD-DRDASDGEDE 137
VQ S+GV +R F L +LI Y + N GLV L PV E E D + D +
Sbjct: 63 FTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQYPVPLEEEDTGDDPEEDTVESVVS 122
Query: 138 KPPLPPRSGSTSISAPTGPSSPLP-----APETPTAPAAESAPNGLSTVS---------- 182
P LPPR+ + S+ P A ET +E+ L ++
Sbjct: 123 PPELPPRNIPLTASSCEAKEVPFSNENPRATETSRPSLSETLFQRLQSMDTSGLPEEHLK 182
Query: 183 --HDYLKGSYGLDLEAVRGGASHLPHLTRTLATSCRRLHSEVDKVLSGLEILSKVFDQQS 240
DYL D E V+ G+S LPHL + C+ L+ EV + L LE L ++FDQQ
Sbjct: 183 AIQDYLSTQLAQDSEFVKTGSSSLPHLKKLTTLLCKELYGEVIRTLPSLESLQRLFDQQL 242
Query: 241 SPMVTRLLQQQNLPQTGEQELESLVLKLSVLKDFLSGIQKKALKALQDMSSTAPPAPQPS 300
SP L + +P GE ++V KLS L LS I+ K +KAL +P P
Sbjct: 243 SP---GLRPRPQVP--GEANPINMVSKLSQLTSLLSSIEDK-VKALLHEGPESPHRPS-- 294
Query: 301 TRKAKTIPVQAFEVKLDVTLGDLTKIGKSQKFTLSVDVEGGRLVLLRRQRDSQEDWTTFT 360
IP FEVK + +G QK L VDVE G+L++ ++ +D ED ++
Sbjct: 295 -----LIPPVTFEVKAE-------SLGIPQKMQLKVDVESGKLII-KKSKDGSED-KFYS 340
Query: 361 HDRIRQLIKSQRVQNKLGVVFEKEKDRTQRKDFIFVSARKREAFCQLLQLMKNKHSKQDE 420
H +I QLIKSQ+ NKL ++ E EK++ RK+++F ++KRE FCQLLQ MKNKHS+Q E
Sbjct: 341 HKKILQLIKSQKFLNKLVILVETEKEKILRKEYVFADSKKREGFCQLLQQMKNKHSEQPE 400
Query: 421 PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVGDRE 480
PDMI++FIGTWNMG+ PPPK +TSWF SKG GKT D+ IPHDIYV GTQE+ + ++E
Sbjct: 401 PDMITIFIGTWNMGNAPPPKKITSWFLSKGQGKTRDDSADYIPHDIYVIGTQEDPLSEKE 460
Query: 481 WLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGN 540
WL++L+ L+E+T + ++ +A+ +LWNI++ VL KPEHENRISH+ T +VKTGIANTLGN
Sbjct: 461 WLEILKHSLQEITSVTFKTVAIHTLWNIRIVVLAKPEHENRISHICTDNVKTGIANTLGN 520
Query: 541 KGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFT 600
KGAVGVSFMFNGTS GFVN HLTSG+EK RRNQNY++ILR L+LGD++L+ F+I+ RFT
Sbjct: 521 KGAVGVSFMFNGTSLGFVNSHLTSGSEKKLRRNQNYMNILRFLALGDKKLSPFNITHRFT 580
Query: 601 HLFWFGDLNYRLDM---DIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISF 657
HLFWFGDLNYR+D+ + + I+ I ++++ LL DQL ER + KVFL F EEEI+F
Sbjct: 581 HLFWFGDLNYRVDLPTWEAETIIQKIKQQQYADLLSHDQLLTERREQKVFLHFEEEEITF 640
Query: 658 PPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDDIVTSD 717
PTYR+ER +RD YA+ KQK TG++ N+PSWCDR+LWKSYP H++C SYG T DI+TSD
Sbjct: 641 APTYRFERLTRDKYAYTKQKATGMKYNLPSWCDRVLWKSYPLVHVVCQSYGSTSDIMTSD 700
Query: 718 HSPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEY 777
HSPVF TFE GVTSQF+SK G Q IEF A +KT S+TKF++EF+S+CLE +
Sbjct: 701 HSPVFATFEAGVTSQFVSKNGPGTVDSQGQIEFLRCYATLKTKSQTKFYLEFHSSCLESF 760
Query: 778 KKSFENDAQSSDNINFLKVQWSSRQLPTLKPILADIEYLQDQHLLLTVKSMDGYESYGEC 837
KS E + + L V++ LP LKPI++D EYL DQH+L+++KS D ESYGE
Sbjct: 761 VKSQEGENEEGSE-GELVVKF-GETLPKLKPIISDPEYLLDQHILISIKSSDSDESYGEG 818
Query: 838 VVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAG 897
+AL+ T T L+H GE TG+ +G +K++ T + TRE+LY+++ ++DE+
Sbjct: 819 CIALRLEATETQLPIYTPLTHHGELTGHFQGEIKLQ--TSQGKTREKLYDFVKTERDESS 876
Query: 898 AKSKAPSVSRGSQEPRS----GSRKPAFTEASCPLSRLFEEPEKPPPTGRPP-APPRAAP 952
S++ S +P SR P + +S E P G P PP
Sbjct: 877 GPKTLKSLT--SHDPMKQWEVTSRAPPCSGSS------ITEIINPNYMGVGPFGPPMPLH 928
Query: 953 REEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSA 1012
++ L+P +P + PPK+S P G P +PP + +PS
Sbjct: 929 VKQTLSPDQQPTAWSYDQ-----PPKDSPLGPC----RGESPPTPPGQPPISPKKFLPST 979
Query: 1013 TKNKVAITVPAPQLGHHRHPRVGEGSSSD--EESGGTLPPPDFP--PPPLPDSAIFLPPS 1068
+ PR E SD + +G TLP D P P + ++ ++ S
Sbjct: 980 ANRGLP-------------PRTQESRPSDLGKNAGDTLPQEDLPLTKPEMFENPLY--GS 1024
Query: 1069 LDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGD 1117
L P P R + P P+ P P PG S L + D
Sbjct: 1025 LSSFPKPAPR----KDQESPKMPRKEPPPCPEPGILSPSIVLTKAQEAD 1069
>gi|13325070 phosphatidylinositol polyphosphate 5-phosphatase
isoform b [Homo sapiens]
Length = 893
Score = 167 bits (423), Expect = 6e-41
Identities = 106/317 (33%), Positives = 162/317 (51%), Gaps = 38/317 (11%)
Query: 427 FIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQE-----------NS 475
F+GTWN+ P + W P DIY G QE S
Sbjct: 243 FVGTWNVNGQSPDSGLEPWLNCD-----------PNPPDIYCIGFQELDLSTEAFFYFES 291
Query: 476 VGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIA 535
V ++EW + GL + Y+ + + L + + + + + I ++T +V TGI
Sbjct: 292 VKEQEWSMAVERGLH--SKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIM 349
Query: 536 NTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLS--LGDRQLNAF 593
+GNKG V V F+F+ T+F VN HL + E RRNQ+Y DI +S + ++ L
Sbjct: 350 GKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQL 409
Query: 594 DISLRFTHLFWFGDLNYRLDM-DIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSE 652
+I ++ + W GDLNYRL M D E+ + I++K+ + LL+ DQLN++R + K F+ F+E
Sbjct: 410 NI-MKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNE 468
Query: 653 EEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDD 712
EI F PTY+Y+ T W + + VP+WCDRILW+ T++ +Y +
Sbjct: 469 GEIKFIPTYKYD---SKTDRW----DSSGKCRVPAWCDRILWRG---TNVNQLNYRSHME 518
Query: 713 IVTSDHSPVFGTFEVGV 729
+ TSDH PV F +GV
Sbjct: 519 LKTSDHKPVSALFHIGV 535
>gi|13325072 phosphatidylinositol polyphosphate 5-phosphatase
isoform a [Homo sapiens]
Length = 901
Score = 167 bits (423), Expect = 6e-41
Identities = 106/317 (33%), Positives = 162/317 (51%), Gaps = 38/317 (11%)
Query: 427 FIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQE-----------NS 475
F+GTWN+ P + W P DIY G QE S
Sbjct: 243 FVGTWNVNGQSPDSGLEPWLNCD-----------PNPPDIYCIGFQELDLSTEAFFYFES 291
Query: 476 VGDREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIA 535
V ++EW + GL + Y+ + + L + + + + + I ++T +V TGI
Sbjct: 292 VKEQEWSMAVERGLH--SKAKYKKVQLVRLVGMMLLIFARKDQCRYIRDIATETVGTGIM 349
Query: 536 NTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLS--LGDRQLNAF 593
+GNKG V V F+F+ T+F VN HL + E RRNQ+Y DI +S + ++ L
Sbjct: 350 GKMGNKGGVAVRFVFHNTTFCIVNSHLAAHVEDFERRNQDYKDICARMSFVVPNQTLPQL 409
Query: 594 DISLRFTHLFWFGDLNYRLDM-DIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSE 652
+I ++ + W GDLNYRL M D E+ + I++K+ + LL+ DQLN++R + K F+ F+E
Sbjct: 410 NI-MKHEVVIWLGDLNYRLCMPDANEVKSLINKKDLQRLLKFDQLNIQRTQKKAFVDFNE 468
Query: 653 EEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGCTDD 712
EI F PTY+Y+ T W + + VP+WCDRILW+ T++ +Y +
Sbjct: 469 GEIKFIPTYKYD---SKTDRW----DSSGKCRVPAWCDRILWRG---TNVNQLNYRSHME 518
Query: 713 IVTSDHSPVFGTFEVGV 729
+ TSDH PV F +GV
Sbjct: 519 LKTSDHKPVSALFHIGV 535
>gi|113722125 inositol polyphosphate-5-phosphatase, 75kDa precursor
[Homo sapiens]
Length = 913
Score = 161 bits (407), Expect = 4e-39
Identities = 111/334 (33%), Positives = 158/334 (47%), Gaps = 43/334 (12%)
Query: 415 HSKQDEPDMISV-----FIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVF 469
H Q E D + F GT+N+ P + + W ++ + P D+Y
Sbjct: 251 HLLQKEEDYTYIQNFRFFAGTYNVNGQSPKECLRLWLSNG----------IQAP-DVYCV 299
Query: 470 GTQENSVG-----------DREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEH 518
G QE + + EW + GL D Y + + L I + + VK EH
Sbjct: 300 GFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHP--DAKYAKVKLIRLVGIMLLLYVKQEH 357
Query: 519 ENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLD 578
IS V +V TGI +GNKG V + F F+ TS VN HL + E+ RRNQ+Y D
Sbjct: 358 AAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSHLAAHIEEYERRNQDYKD 417
Query: 579 ILRLLSL--GDRQLNAFDISLRFTHLFWFGDLNYRL-DMDIQEILNYISRKEFEPLLRVD 635
I + D L IS + W GDLNYR+ ++D++++ I K+F+ L D
Sbjct: 418 ICSRMQFCQPDPSLPPLTIS-NHDVILWLGDLNYRIEELDVEKVKKLIEEKDFQMLYAYD 476
Query: 636 QLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWK 695
QL ++ VF F+E E++F PTY+Y+ GS D W T + P+WCDRILWK
Sbjct: 477 QLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDD---W----DTSEKCRAPAWCDRILWK 529
Query: 696 SYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGV 729
T + SY + TSDH PV F++GV
Sbjct: 530 GKNITQL---SYQSHMALKTSDHKPVSSVFDIGV 560
>gi|237757312 synaptojanin 1 isoform c [Homo sapiens]
Length = 1295
Score = 158 bits (400), Expect = 3e-38
Identities = 204/819 (24%), Positives = 325/819 (39%), Gaps = 166/819 (20%)
Query: 401 REAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNV-------TSWFTSK---- 449
+ A ++L+ M K +P I V +GTWN+ +++ T W
Sbjct: 510 QSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLA 569
Query: 450 GLGKTLDEVTVTIPHDIYVFGTQE------------NSVGDREWLDLLRGGLKELTDLDY 497
G+ + D+ + P DI+ G +E ++ + W L+ + D Y
Sbjct: 570 GIQEFQDKRSK--PTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISR--DNKY 625
Query: 498 RPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGF 557
+A + L + + V ++P+H I V+ +VKTG+ GNKGAV + +F+ TS F
Sbjct: 626 VLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCF 685
Query: 558 VNCHLTSGNEKTARRNQNYLDILRLLSLG-DRQLNAFDISLRFTHLFWFGDLNYRLDMDI 616
V H +G + RN+++++I R LS R L + D ++FW GD NYR+D+
Sbjct: 686 VCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHD------YVFWCGDFNYRIDLPN 739
Query: 617 QEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQ 676
+E+ I ++ ++ L+ DQL ++ +VF F E +++F PTY+Y+ S D
Sbjct: 740 EEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDD------- 792
Query: 677 KPTGVRTNVPSWCDRILW--------KSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVG 728
T + P+W DR+LW +S + ++ S+ D S + T+ G
Sbjct: 793 YDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASF--------QDESKILYTWTPG 844
Query: 729 VTSQFISKKGLSKTSDQ----AYIEFESIEAIVKTASRTKFFIEFYS-------TCLEEY 777
+ + KTSD A I+ + E V+ R + E + T L
Sbjct: 845 TLLHY--GRAELKTSDHRPVVALIDIDIFE--VEAEERQNIYKEVIAVQGPPDGTVLVSI 900
Query: 778 KKSF-ENDAQSSDNINFLKVQWSSRQLPTLKPILAD---IEYLQDQHLLLTVKSMDGYES 833
K S EN+ I+ L Q++S L + D + +L+ L V S++G E
Sbjct: 901 KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSS-ALNVLSLNGKEL 959
Query: 834 YGECV-VALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGT----------- 881
+ +ALKS ++ + EE + + +P+ T
Sbjct: 960 LNRTITIALKSP---------DWIKNLEEEMS--LEKISIALPSSTSSTLLGEDAEVAAD 1008
Query: 882 --RERLYEWISIDKDEAGAKSKAPSVSRG-----SQEPR-SGSRKPAFTEASCPLSRLFE 933
E + S + +E + PS S G S PR S + P +E P+ L
Sbjct: 1009 FDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEG--PVPSLPI 1066
Query: 934 EPEKPPPTGRPPAPPRAAPR---EEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLE 990
P + P R P PP A +P TP + + A E PPP+ P
Sbjct: 1067 RPSRAP--SRTPGPPSAQSSPIDAQPATPLPQKDPAQPLEPKRPPPPR-----PVAPPTR 1119
Query: 991 GVPHQLLPPEPPSPARAPVP------------SATKNKVAITVPAPQLG----------- 1027
P Q P PPS AR+P P + K+ + + P+PQ G
Sbjct: 1120 PAPPQ--RPPPPSGARSPAPTRKEFGAPKSPGTTRKDNIGRSQPSPQAGLAGPGPAGYST 1177
Query: 1028 --------------HHRHPRVGEG---SSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLD 1070
H R G S ++ T F P PL A F P S
Sbjct: 1178 ARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEPLKPQAAFPPQS-- 1235
Query: 1071 PLPGPVVRGRGGAEARGPPPPKAHPRPPL--PPGPSPAS 1107
LP P R + P P++ P+P L PP P P S
Sbjct: 1236 SLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRS 1274
>gi|237757326 synaptojanin 1 isoform d [Homo sapiens]
Length = 1526
Score = 157 bits (396), Expect = 8e-38
Identities = 200/789 (25%), Positives = 316/789 (40%), Gaps = 136/789 (17%)
Query: 403 AFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNV-------TSWFTSK----GL 451
A ++L+ M K +P I V +GTWN+ +++ T W G+
Sbjct: 507 ASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLAGI 566
Query: 452 GKTLDEVTVTIPHDIYVFGTQE------------NSVGDREWLDLLRGGLKELTDLDYRP 499
+ D+ + P DI+ G +E ++ + W L+ + D Y
Sbjct: 567 QEFQDKRSK--PTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISR--DNKYVL 622
Query: 500 IAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVN 559
+A + L + + V ++P+H I V+ +VKTG+ GNKGAV + +F+ TS FV
Sbjct: 623 LASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCFVC 682
Query: 560 CHLTSGNEKTARRNQNYLDILRLLSLG-DRQLNAFDISLRFTHLFWFGDLNYRLDMDIQE 618
H +G + RN+++++I R LS R L + D ++FW GD NYR+D+ +E
Sbjct: 683 SHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHD------YVFWCGDFNYRIDLPNEE 736
Query: 619 ILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKP 678
+ I ++ ++ L+ DQL ++ +VF F E +++F PTY+Y+ S D
Sbjct: 737 VKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDD-------YD 789
Query: 679 TGVRTNVPSWCDRILW--------KSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVT 730
T + P+W DR+LW +S + ++ S+ D S + T+ G
Sbjct: 790 TSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASF--------QDESKILYTWTPGTL 841
Query: 731 SQFISKKGLSKTSDQ----AYIEFESIEAIVKTASRTKFFIEFYS-------TCLEEYKK 779
+ + KTSD A I+ + E V+ R + E + T L K
Sbjct: 842 LHY--GRAELKTSDHRPVVALIDIDIFE--VEAEERQNIYKEVIAVQGPPDGTVLVSIKS 897
Query: 780 SF-ENDAQSSDNINFLKVQWSSRQLPTLKPILAD---IEYLQDQHLLLTVKSMDGYESYG 835
S EN+ I+ L Q++S L + D + +L+ L V S++G E
Sbjct: 898 SLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSS-ALNVLSLNGKELLN 956
Query: 836 ECV-VALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGT------------- 881
+ +ALKS ++ + EE + + +P+ T
Sbjct: 957 RTITIALKSP---------DWIKNLEEEMS--LEKISIALPSSTSSTLLGEDAEVAADFD 1005
Query: 882 RERLYEWISIDKDEAGAKSKAPSVSRG-----SQEPR-SGSRKPAFTEASCPLSRLFEEP 935
E + S + +E + PS S G S PR S + P +E P+ L P
Sbjct: 1006 MEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEG--PVPSLPIRP 1063
Query: 936 EKPPPTGRPPAPPRA------------APREEPLTPRLKPEGAPEPEGVAAPPPKNSFNN 983
+ P R P PP A P+++P P L+P+ P P VA P
Sbjct: 1064 SRAP--SRTPGPPSAQSSPIDAQPATPLPQKDPAQP-LEPKRPPPPRPVAPPTRPAPPQR 1120
Query: 984 PAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEG---SSS 1040
P P P PA T A + APQ H R G S
Sbjct: 1121 PPPPSGRSQPSPQAGLAGPGPAGYSTARPTIPPRAGVISAPQ----SHARASAGRLTPES 1176
Query: 1041 DEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPL- 1099
++ T F P PL A F P S LP P R + P P++ P+P L
Sbjct: 1177 QSKTSETSKGSTFLPEPLKPQAAFPPQS--SLPPPAQRLQEPLVPVAAPMPQSGPQPNLE 1234
Query: 1100 -PPGPSPAS 1107
PP P P S
Sbjct: 1235 TPPQPPPRS 1243
Score = 37.4 bits (85), Expect = 0.091
Identities = 65/230 (28%), Positives = 85/230 (36%), Gaps = 44/230 (19%)
Query: 988 VLEGVPHQLLPPEPP----SPARAPVPSATKNKVAITVPAPQLGHH--RHPRVGEGSSSD 1041
V E +P L P SP+ +P S ++ P P L R P G S
Sbjct: 1017 VEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEGPVPSLPIRPSRAPSRTPGPPSA 1076
Query: 1042 EESGGTLPPPDFPPPPLP--DSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPP- 1098
+ S P P PLP D A L P P P PV A + PPPP +P
Sbjct: 1077 QSS----PIDAQPATPLPQKDPAQPLEPKRPPPPRPVAPPTRPAPPQRPPPPSGRSQPSP 1132
Query: 1099 ----LPPGPSPASTF-------LGEVASGDD--RSCSVLQMAKTLSEVDYAPAGPARSAL 1145
PGP+ ST G +++ R+ + ++ S+ G S
Sbjct: 1133 QAGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKG---STF 1189
Query: 1146 LPGPLELQ---PPRGLPSDYGRPLSFPPPRIRESIQEDLAE-EAPCLQGG 1191
LP PL+ Q PP+ S PPP R +QE L AP Q G
Sbjct: 1190 LPEPLKPQAAFPPQS---------SLPPPAQR--LQEPLVPVAAPMPQSG 1228
>gi|237757310 synaptojanin 1 isoform a [Homo sapiens]
Length = 1612
Score = 154 bits (388), Expect = 7e-37
Identities = 208/832 (25%), Positives = 331/832 (39%), Gaps = 176/832 (21%)
Query: 401 REAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNV-------TSWFTSK---- 449
+ A ++L+ M K +P I V +GTWN+ +++ T W
Sbjct: 549 QSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLA 608
Query: 450 GLGKTLDEVTVTIPHDIYVFGTQE------------NSVGDREWLDLLRGGLKELTDLDY 497
G+ + D+ + P DI+ G +E ++ + W L+ + D Y
Sbjct: 609 GIQEFQDKRSK--PTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISR--DNKY 664
Query: 498 RPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGF 557
+A + L + + V ++P+H I V+ +VKTG+ GNKGAV + +F+ TS F
Sbjct: 665 VLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCF 724
Query: 558 VNCHLTSGNEKTARRNQNYLDILRLLSLG-DRQLNAFDISLRFTHLFWFGDLNYRLDMDI 616
V H +G + RN+++++I R LS R L + D ++FW GD NYR+D+
Sbjct: 725 VCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHD------YVFWCGDFNYRIDLPN 778
Query: 617 QEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQ 676
+E+ I ++ ++ L+ DQL ++ +VF F E +++F PTY+Y+ S D
Sbjct: 779 EEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDD------- 831
Query: 677 KPTGVRTNVPSWCDRILW--------KSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVG 728
T + P+W DR+LW +S + ++ S+ D S + T+ G
Sbjct: 832 YDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASF--------QDESKILYTWTPG 883
Query: 729 VTSQFISKKGLSKTSDQ----AYIEFESIEAIVKTASRTKFFIEFYS-------TCLEEY 777
+ + KTSD A I+ + E V+ R + E + T L
Sbjct: 884 TLLHY--GRAELKTSDHRPVVALIDIDIFE--VEAEERQNIYKEVIAVQGPPDGTVLVSI 939
Query: 778 KKSF-ENDAQSSDNINFLKVQWSSRQLPTLKPILAD---IEYLQDQHLLLTVKSMDGYES 833
K S EN+ I+ L Q++S L + D + +L+ L V S++G E
Sbjct: 940 KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSS-ALNVLSLNGKEL 998
Query: 834 YGECV-VALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGT----------- 881
+ +ALKS ++ + EE + + +P+ T
Sbjct: 999 LNRTITIALKSP---------DWIKNLEEEMS--LEKISIALPSSTSSTLLGEDAEVAAD 1047
Query: 882 --RERLYEWISIDKDEAGAKSKAPSVSRG-----SQEPR-SGSRKPAFTEASCPLSRLFE 933
E + S + +E + PS S G S PR S + P +E P+ L
Sbjct: 1048 FDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEG--PVPSLPI 1105
Query: 934 EPEKPPPTGRPPAPPRA------------APREEPLTPRLKPEGAPEPEGVA-------- 973
P + P R P PP A P+++P P L+P+ P P VA
Sbjct: 1106 RPSRAP--SRTPGPPSAQSSPIDAQPATPLPQKDPAQP-LEPKRPPPPRPVAPPTRPAPP 1162
Query: 974 -APPPKNSFNNPAYYVLE--GVPHQLLPPEPPSPAR---APVPSAT--KNKVAITVPAPQ 1025
PPP + +PA E G+ PP P R AP T K+ + + P+PQ
Sbjct: 1163 QRPPPPSGARSPAPTRKEFGGIG---APPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQ 1219
Query: 1026 LG-------------------------HHRHPRVGEG---SSSDEESGGTLPPPDFPPPP 1057
G H R G S ++ T F P P
Sbjct: 1220 AGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEP 1279
Query: 1058 LPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPL--PPGPSPAS 1107
L A F P S LP P R + P P++ P+P L PP P P S
Sbjct: 1280 LKPQAAFPPQS--SLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRS 1329
>gi|237757308 synaptojanin 1 isoform b [Homo sapiens]
Length = 1350
Score = 154 bits (388), Expect = 7e-37
Identities = 208/832 (25%), Positives = 331/832 (39%), Gaps = 176/832 (21%)
Query: 401 REAFCQLLQLMKNKHSKQDEPDMISVFIGTWNMGSVPPPKNV-------TSWFTSK---- 449
+ A ++L+ M K +P I V +GTWN+ +++ T W
Sbjct: 549 QSASSKVLKSMCENFYKYSKPKKIRVCVGTWNVNGGKQFRSIAFKNQTLTDWLLDAPKLA 608
Query: 450 GLGKTLDEVTVTIPHDIYVFGTQE------------NSVGDREWLDLLRGGLKELTDLDY 497
G+ + D+ + P DI+ G +E ++ + W L+ + D Y
Sbjct: 609 GIQEFQDKRSK--PTDIFAIGFEEMVELNAGNIVSASTTNQKLWAVELQKTISR--DNKY 664
Query: 498 RPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGF 557
+A + L + + V ++P+H I V+ +VKTG+ GNKGAV + +F+ TS F
Sbjct: 665 VLLASEQLVGVCLFVFIRPQHAPFIRDVAVDTVKTGMGGATGNKGAVAIRMLFHTTSLCF 724
Query: 558 VNCHLTSGNEKTARRNQNYLDILRLLSLG-DRQLNAFDISLRFTHLFWFGDLNYRLDMDI 616
V H +G + RN+++++I R LS R L + D ++FW GD NYR+D+
Sbjct: 725 VCSHFAAGQSQVKERNEDFIEIARKLSFPMGRMLFSHD------YVFWCGDFNYRIDLPN 778
Query: 617 QEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQ 676
+E+ I ++ ++ L+ DQL ++ +VF F E +++F PTY+Y+ S D
Sbjct: 779 EEVKELIRQQNWDSLIAGDQLINQKNAGQVFRGFLEGKVTFAPTYKYDLFSDD------- 831
Query: 677 KPTGVRTNVPSWCDRILW--------KSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVG 728
T + P+W DR+LW +S + ++ S+ D S + T+ G
Sbjct: 832 YDTSEKCRTPAWTDRVLWRRRKWPFDRSAEDLDLLNASF--------QDESKILYTWTPG 883
Query: 729 VTSQFISKKGLSKTSDQ----AYIEFESIEAIVKTASRTKFFIEFYS-------TCLEEY 777
+ + KTSD A I+ + E V+ R + E + T L
Sbjct: 884 TLLHY--GRAELKTSDHRPVVALIDIDIFE--VEAEERQNIYKEVIAVQGPPDGTVLVSI 939
Query: 778 KKSF-ENDAQSSDNINFLKVQWSSRQLPTLKPILAD---IEYLQDQHLLLTVKSMDGYES 833
K S EN+ I+ L Q++S L + D + +L+ L V S++G E
Sbjct: 940 KSSLPENNFFDDALIDELLQQFASFGEVILIRFVEDKMWVTFLEGSS-ALNVLSLNGKEL 998
Query: 834 YGECV-VALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGT----------- 881
+ +ALKS ++ + EE + + +P+ T
Sbjct: 999 LNRTITIALKSP---------DWIKNLEEEMS--LEKISIALPSSTSSTLLGEDAEVAAD 1047
Query: 882 --RERLYEWISIDKDEAGAKSKAPSVSRG-----SQEPR-SGSRKPAFTEASCPLSRLFE 933
E + S + +E + PS S G S PR S + P +E P+ L
Sbjct: 1048 FDMEGDVDDYSAEVEELLPQHLQPSSSSGLGTSPSSSPRTSPCQSPTISEG--PVPSLPI 1105
Query: 934 EPEKPPPTGRPPAPPRA------------APREEPLTPRLKPEGAPEPEGVA-------- 973
P + P R P PP A P+++P P L+P+ P P VA
Sbjct: 1106 RPSRAP--SRTPGPPSAQSSPIDAQPATPLPQKDPAQP-LEPKRPPPPRPVAPPTRPAPP 1162
Query: 974 -APPPKNSFNNPAYYVLE--GVPHQLLPPEPPSPAR---APVPSAT--KNKVAITVPAPQ 1025
PPP + +PA E G+ PP P R AP T K+ + + P+PQ
Sbjct: 1163 QRPPPPSGARSPAPTRKEFGGIG---APPSPGVARREMEAPKSPGTTRKDNIGRSQPSPQ 1219
Query: 1026 LG-------------------------HHRHPRVGEG---SSSDEESGGTLPPPDFPPPP 1057
G H R G S ++ T F P P
Sbjct: 1220 AGLAGPGPAGYSTARPTIPPRAGVISAPQSHARASAGRLTPESQSKTSETSKGSTFLPEP 1279
Query: 1058 LPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPL--PPGPSPAS 1107
L A F P S LP P R + P P++ P+P L PP P P S
Sbjct: 1280 LKPQAAFPPQS--SLPPPAQRLQEPLVPVAAPMPQSGPQPNLETPPQPPPRS 1329
>gi|26190608 synaptojanin 2 [Homo sapiens]
Length = 1496
Score = 153 bits (387), Expect = 9e-37
Identities = 206/870 (23%), Positives = 326/870 (37%), Gaps = 175/870 (20%)
Query: 406 QLLQLMKNKHSKQDEPDMISVFIGTWNMG-------SVPPPKNVTSWFT-SKGLGKTLDE 457
++L+ M + S+ I + +GTWN+ +V +T W S L D
Sbjct: 512 RILKAMTERQSEFTNFKRIRIAMGTWNVNGGKQFRSNVLRTAELTDWLLDSPQLSGATDS 571
Query: 458 VTVTIPHDIYVFGTQE------------NSVGDREWLDLLRGGLKELTDLDYRPIAMQS- 504
+ P DI+ G +E ++ + W + L+ + +R I + S
Sbjct: 572 QDDSSPADIFAVGFEEMVELSAGNIVNASTTNKKMWGEQLQKAISR----SHRYILLTSA 627
Query: 505 -LWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLT 563
L + + + V+P H I V+ +VKTG+ GNKGAVG+ F F+ TSF F+ HLT
Sbjct: 628 QLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLT 687
Query: 564 SGNEKTARRNQNYLDILRLLSLGDRQLNAFDISLRFTHLFWFGDLNYRLDMDIQEILNYI 623
+G + RN++Y +I + L + N F ++FW GD NYR+D+ +E+ ++
Sbjct: 688 AGQSQVKERNEDYKEITQKLCFPMGR-NVFS----HDYVFWCGDFNYRIDLTYEEVFYFV 742
Query: 624 SRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRT 683
R++++ LL DQL L++ K+F F E I+F PTY+Y+ GS T +
Sbjct: 743 KRQDWKKLLEFDQLQLQKSSGKIFKDFHEGAINFGPTYKYDVGS-------AAYDTSDKC 795
Query: 684 NVPSWCDRILW--KSYP------ETHIICN-----------------SYGCTDDIVTSDH 718
P+W DR+LW K +P E +++ + Y ++ SDH
Sbjct: 796 RTPAWTDRVLWWRKKHPFDKTAGELNLLDSDLDVDTKVRHTWSPGALQYYGRAELQASDH 855
Query: 719 SPVFGTFEVGVTSQFISKKGLSKTSDQAYIEFESIEAIVKTASRTKFFIEFYSTCLEEYK 778
PV EV V + + ++ + E S + + + S LEE K
Sbjct: 856 RPVLAIVEVEVQEVDVGAR------ERVFQEVSSFQGPLDAT----VVVNLQSPTLEE-K 904
Query: 779 KSFENDAQSSDNINFLKVQWSSRQLPTLKPILAD-IEYLQDQHLLLTVKSMDGYESYGEC 837
F D ++ ++ S + ++ + D H L+V +DG + G
Sbjct: 905 NEFPEDLRT----ELMQTLGSYGTIVLVRINQGQMLVTFADSHSALSVLDVDGMKVKGRA 960
Query: 838 VVALKSMIGSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKDEAG 897
V I + +L L EE R SM PT E +++ S+D + G
Sbjct: 961 V-----KIRPKTKDWLKGLR---EEIIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEG 1012
Query: 898 -----------AKSKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPA 946
+ P VS S P T + P +K PT + A
Sbjct: 1013 DILEDDEDYLVDEFNQPGVSDSELGGDDLSDVPGPTALAPPSKSPALTKKKQHPTYKDDA 1072
Query: 947 -------------------PPRAAPREEPLTPRLKPEGAPEPEGV-----AAPPPKNSFN 982
P R+ P P+ P P G+ A+ +S
Sbjct: 1073 DLVELKRELEAVGEFRHRSPSRSLSVPNRPRPPQPPQRPPPPTGLMVKKSASDASISSGT 1132
Query: 983 NPAYYVLEGVPHQLLPPEPPSPARA-------------PVPSATKNKVAITVPAPQLGHH 1029
+ Y +L+ +LLP P P +A +A + + AI G
Sbjct: 1133 HGQYSILQTA--RLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEARGGA 1190
Query: 1030 RH-------PRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGG 1082
PR E SS E + G P PPL PP + + P +R G
Sbjct: 1191 SEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRR--PPPRVPAIKKPTLRRTGK 1248
Query: 1083 AEAR-------------GPP-----PPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVL 1124
+ GPP P P +PP P P + G+ A
Sbjct: 1249 PLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVPKPRTFQPGKAAE--------- 1299
Query: 1125 QMAKTLSEVDYAPAGPARSALLPGPLELQP 1154
+ + D AP P A +P PLE P
Sbjct: 1300 RPSHRKPASDEAP--PGAGASVPPPLEAPP 1327
Score = 42.0 bits (97), Expect = 0.004
Identities = 43/164 (26%), Positives = 61/164 (37%), Gaps = 13/164 (7%)
Query: 901 KAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAP--PRAAPREEPLT 958
+A + R E R G+ + A + + EPE P +P P P PR P
Sbjct: 1175 EAEAAIRCLLEARGGASEEALSAVAPRDLEASSEPEPTPGAAKPETPQAPPLLPRRPP-- 1232
Query: 959 PRLKPEGAPEPEGVAAP-PPKNSFNNPAYYVLEGVPHQLL--PPEPPSPARAPVPSATKN 1015
PR+ P P P+ F + G P + PP +P PVP K
Sbjct: 1233 PRVPAIKKPTLRRTGKPLSPEEQFEQQTVHFTIGPPETSVEAPPVVTAPRVPPVP---KP 1289
Query: 1016 KVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLP 1059
+ A + HR P E +G ++PPP PP +P
Sbjct: 1290 RTFQPGKAAERPSHRKPASDEAPPG---AGASVPPPLEAPPLVP 1330
>gi|38327539 inositol polyphosphate-5-phosphatase E [Homo sapiens]
Length = 644
Score = 137 bits (345), Expect = 6e-32
Identities = 102/320 (31%), Positives = 155/320 (48%), Gaps = 37/320 (11%)
Query: 424 ISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIP----HDIYVFGTQENSVGDR 479
+++F+ TWNM K L +LDE + D+YV G QE R
Sbjct: 299 VALFVATWNMQG------------QKELPPSLDEFLLPAEADYAQDLYVIGVQEGCSDRR 346
Query: 480 EWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLG 539
EW L+E Y ++ + + +++ ++ + S V S+V T I + +
Sbjct: 347 EW----ETRLQETLGPHYVLLSSAAHGVLYMSLFIRRDLIWFCSEVECSTVTTRIVSQIK 402
Query: 540 NKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSL-------GDRQLNA 592
KGA+G+SF F GTSF F+ H TSG+ K A R +Y ++ L L + +A
Sbjct: 403 TKGALGISFTFFGTSFLFITSHFTSGDGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSA 462
Query: 593 FDISLRFTHLFWFGDLNYRLD---MDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLR 649
D++ RF +FWFGD N+RL + +L + LL+ DQL E K +F
Sbjct: 463 ADVTTRFDEVFWFGDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGSIFKG 522
Query: 650 FSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSYPETHIICNSYGC 709
F E +I F P+Y+++ G +DTY ++ T PS+ DR+L++S + I SY
Sbjct: 523 FQEPDIHFLPSYKFDIG-KDTYDSTSKQRT------PSYTDRVLYRSRHKGDICPVSYSS 575
Query: 710 TDDIVTSDHSPVFGTFEVGV 729
I TSDH PV+G F V V
Sbjct: 576 CPGIKTSDHRPVYGLFRVKV 595
Score = 30.8 bits (68), Expect = 8.5
Identities = 18/56 (32%), Positives = 23/56 (41%), Gaps = 3/56 (5%)
Query: 120 EREPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAP 175
E P PP+ R + + P PP + S G SP A TP P+ E P
Sbjct: 12 EPAPQPPEGRTL---QGQLPGAPPAQRAGSPPDAPGSESPALACSTPATPSGEDPP 64
>gi|18765709 inositol polyphosphate-5-phosphatase K isoform 1 [Homo
sapiens]
Length = 448
Score = 119 bits (299), Expect = 1e-26
Identities = 90/330 (27%), Positives = 141/330 (42%), Gaps = 49/330 (14%)
Query: 424 ISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQENSVG------ 477
+S+ + TWN+ S PP +++ LD IYV G QE + G
Sbjct: 14 LSIHVVTWNVASAAPPLDLSDLLQLNNRNLNLD---------IYVIGLQELNSGIISLLS 64
Query: 478 ----DREWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTG 533
+ W L L L+ + + MQ I + V K +H I +ST S TG
Sbjct: 65 DAAFNDSWSSFLMDVLSPLSFIKVSHVRMQG---ILLLVFAKYQHLPYIQILSTKSTPTG 121
Query: 534 IANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQL-NA 592
+ GNKG V + G +NCHL +R +++ IL + + R + N
Sbjct: 122 LFGYWGNKGGVNICLKLYGYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPNI 181
Query: 593 FDISLRFTHLFWFGDLNYRL-DMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFS 651
D L + WFGD+N+R+ D + + I + + L DQL++ ++ + F
Sbjct: 182 LDHDL----IIWFGDMNFRIEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQ 237
Query: 652 EEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWKSY------------PE 699
E + FPPTY+++R S D T + P+W DRILW+ P
Sbjct: 238 EGRLLFPPTYKFDRNSND-------YDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPA 290
Query: 700 THIICNSYGCTDDIV--TSDHSPVFGTFEV 727
+H + G + + SDH PV GTF++
Sbjct: 291 SHFSLSLRGYSSHMTYGISDHKPVSGTFDL 320
>gi|50726960 phosphatidylinositol (4,5) bisphosphate 5-phosphatase,
A [Homo sapiens]
Length = 638
Score = 109 bits (273), Expect = 1e-23
Identities = 91/330 (27%), Positives = 140/330 (42%), Gaps = 46/330 (13%)
Query: 421 PDMISVFIGTWNMGSVPPPKNVTSWFTSKGLGKTLDEVTVTIPHDIYVFGTQE-NSVGDR 479
P + + TWN+G+ PP +VTS G G D D+ G QE NS+ ++
Sbjct: 52 PSEPRITVVTWNVGTAMPPDDVTSLLHLGG-GDDSDGA------DMIAIGLQEVNSMLNK 104
Query: 480 ---------EWLDLLRGGLKELTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSV 530
+W +L L + + MQ + + + K H + V T
Sbjct: 105 RLKDALFTDQWSELFMDALGPFNFVLVSSVRMQG---VILLLFAKYYHLPFLRDVQTDCT 161
Query: 531 KTGIANTLGNKGAVGVSFMFNGTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSL-GDRQ 589
+TG+ GNKG V V G F+NCHL + +K +R N+ IL L G
Sbjct: 162 RTGLGGYWGNKGGVSVRLAAFGHMLCFLNCHLPAHMDKAEQRKDNFQTILSLQQFQGPGA 221
Query: 590 LNAFDISLRFTHLFWFGDLNYRLD-MDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFL 648
D L +FWFGDLN+R++ D+ + I + L DQLN+ + +
Sbjct: 222 QGILDHDL----VFWFGDLNFRIESYDLHFVKFAIDSDQLHQLWEKDQLNMAKNTWPILK 277
Query: 649 RFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRTNVPSWCDRILWK----------SYP 698
F E ++F PT++++ G+ + T + P+W DRILWK S
Sbjct: 278 GFQEGPLNFAPTFKFDVGT-------NKYDTSAKKRKPAWTDRILWKVKAPGGGPSPSGR 330
Query: 699 ETH---IICNSYGCTDDIVTSDHSPVFGTF 725
++H + +SY + SDH PV F
Sbjct: 331 KSHRLQVTQHSYRSHMEYTVSDHKPVAAQF 360
Score = 32.0 bits (71), Expect = 3.8
Identities = 31/99 (31%), Positives = 37/99 (37%), Gaps = 5/99 (5%)
Query: 1004 PARAPVPSATKNKVAITVPAPQ---LGHHRHPRVGEGSS--SDEESGGTLPPPDFPPPPL 1058
P A PS+ + + A P+PQ L R GSS S EE LP P PP +
Sbjct: 527 PGLALRPSSRERRGASRSPSPQSRRLSRVAPDRSSNGSSRGSSEEGPSGLPGPWAFPPAV 586
Query: 1059 PDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRP 1097
P S LP P G G + P P P
Sbjct: 587 PRSLGLLPALRLETVDPGGGGSWGPDREALAPNSLSPSP 625
>gi|208610044 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
sapiens]
Length = 372
Score = 103 bits (257), Expect = 1e-21
Identities = 70/252 (27%), Positives = 114/252 (45%), Gaps = 27/252 (10%)
Query: 492 LTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFN 551
L+ L + ++ + I + V K +H I +ST S TG+ GNKG V +
Sbjct: 4 LSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLY 63
Query: 552 GTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQL-NAFDISLRFTHLFWFGDLNY 610
G +NCHL +R +++ IL + + R + N D L + WFGD+N+
Sbjct: 64 GYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPNILDHDL----IIWFGDMNF 119
Query: 611 RL-DMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRD 669
R+ D + + I + + L DQL++ ++ + F E + FPPTY+++R S D
Sbjct: 120 RIEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSND 179
Query: 670 TYAWHKQKPTGVRTNVPSWCDRILWKSY------------PETHIICNSYGCTDDIV--T 715
T + P+W DRILW+ P +H + G + +
Sbjct: 180 -------YDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGI 232
Query: 716 SDHSPVFGTFEV 727
SDH PV GTF++
Sbjct: 233 SDHKPVSGTFDL 244
>gi|18765707 inositol polyphosphate-5-phosphatase K isoform 2 [Homo
sapiens]
Length = 372
Score = 103 bits (257), Expect = 1e-21
Identities = 70/252 (27%), Positives = 114/252 (45%), Gaps = 27/252 (10%)
Query: 492 LTDLDYRPIAMQSLWNIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFN 551
L+ L + ++ + I + V K +H I +ST S TG+ GNKG V +
Sbjct: 4 LSPLSFIKVSHVRMQGILLLVFAKYQHLPYIQILSTKSTPTGLFGYWGNKGGVNICLKLY 63
Query: 552 GTSFGFVNCHLTSGNEKTARRNQNYLDILRLLSLGDRQL-NAFDISLRFTHLFWFGDLNY 610
G +NCHL +R +++ IL + + R + N D L + WFGD+N+
Sbjct: 64 GYYVSIINCHLPPHISNNYQRLEHFDRILEMQNCEGRDIPNILDHDL----IIWFGDMNF 119
Query: 611 RL-DMDIQEILNYISRKEFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRD 669
R+ D + + I + + L DQL++ ++ + F E + FPPTY+++R S D
Sbjct: 120 RIEDFGLHFVRESIKNRCYGGLWEKDQLSIAKKHDPLLREFQEGRLLFPPTYKFDRNSND 179
Query: 670 TYAWHKQKPTGVRTNVPSWCDRILWKSY------------PETHIICNSYGCTDDIV--T 715
T + P+W DRILW+ P +H + G + +
Sbjct: 180 -------YDTSEKKRKPAWTDRILWRLKRQPCAGPDTPIPPASHFSLSLRGYSSHMTYGI 232
Query: 716 SDHSPVFGTFEV 727
SDH PV GTF++
Sbjct: 233 SDHKPVSGTFDL 244
>gi|54792745 SH2 domain containing 1B [Homo sapiens]
Length = 132
Score = 88.6 bits (218), Expect = 3e-17
Identities = 42/98 (42%), Positives = 64/98 (65%)
Query: 21 WYHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLA 80
+YH L++ E LL + G DG+FL+RDSES+ G LCV ++ V+TYRI + +
Sbjct: 5 YYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKHGYYR 64
Query: 81 VQTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVE 118
+QT++G P + F +L ELI + +PNQG+V LL P++
Sbjct: 65 IQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIK 102
>gi|169234945 SH2 domain protein 1A isoform 2 [Homo sapiens]
Length = 125
Score = 86.3 bits (212), Expect = 2e-16
Identities = 42/97 (43%), Positives = 60/97 (61%)
Query: 22 YHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAV 81
YH +SR E+LL G DGS+L+RDSESV G + LCVLY +++TYR+ +
Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSA 66
Query: 82 QTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVE 118
+T+ GV R F+ + LI + +P+QG+V L PVE
Sbjct: 67 ETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVE 103
>gi|4506923 SH2 domain protein 1A isoform 1 [Homo sapiens]
Length = 128
Score = 86.3 bits (212), Expect = 2e-16
Identities = 42/97 (43%), Positives = 60/97 (61%)
Query: 22 YHRDLSRAAAEELLARAGRDGSFLVRDSESVAGAFALCVLYQKHVHTYRILPDGEDFLAV 81
YH +SR E+LL G DGS+L+RDSESV G + LCVLY +++TYR+ +
Sbjct: 7 YHGKISRETGEKLLLATGLDGSYLLRDSESVPGVYCLCVLYHGYIYTYRVSQTETGSWSA 66
Query: 82 QTSQGVPVRRFQTLGELIGLYAQPNQGLVCALLLPVE 118
+T+ GV R F+ + LI + +P+QG+V L PVE
Sbjct: 67 ETAPGVHKRYFRKIKNLISAFQKPDQGIVIPLQYPVE 103
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 1124
Score = 75.5 bits (184), Expect = 3e-13
Identities = 87/298 (29%), Positives = 107/298 (35%), Gaps = 50/298 (16%)
Query: 902 APSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPP--APPRAAPREEPLTP 959
+PS + SQ P S + P S P S PPP PP APP P P +P
Sbjct: 686 SPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASP 745
Query: 960 RLKPEGAPEPEG---VAAPPPKNSFNNPAYYVLEGVPHQLLPPE-PPSPARAPVPSATKN 1015
+ P P P +AAPP + + PA + P PP+ PP+ A P+ +
Sbjct: 746 PMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMS--PLAKPPPQAPPALATPPLQALPSP 803
Query: 1016 KVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPP----------PPLPDSAIFL 1065
+ AP S+S S PPP PP P P S
Sbjct: 804 PASFPGQAPF----------SPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQ 853
Query: 1066 PPSLDPLPGPVVRGRGGAEARGPPPPKA-HPRPPLPPGPSPASTFLGEVASGDDRSCSVL 1124
P P PGP GP A P PP PP SP+ST G +G S S
Sbjct: 854 APRRPPTPGP------DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAG--HSSSAT 905
Query: 1125 QMAKTLSEVDYAPAGPARSALLPGPLEL------------QPPRGLPSDYGRPLSFPP 1170
+ L D P G A +A P EL PP G PL +PP
Sbjct: 906 STPEELRGYDSGPEGGA-AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPP 962
Score = 60.5 bits (145), Expect = 1e-08
Identities = 74/273 (27%), Positives = 89/273 (32%), Gaps = 35/273 (12%)
Query: 919 PAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPE-PEGVAAPPP 977
P AS PL+ P PP P P + P +P P PE P +A PPP
Sbjct: 544 PPLQTASAPLTT--------PHLETPPCPA-PCPLQAPPSPLTTPP--PETPSSIATPPP 592
Query: 978 KNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEG 1037
+ A L P Q LP P SP P P A + AP P
Sbjct: 593 Q------APPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLA 646
Query: 1038 SSSDEESGGT----LPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKA 1093
+ S + L P PPP P A F PP+ P+ + PP +
Sbjct: 647 TPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV 706
Query: 1094 HPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQ 1153
P PP P SP++T A L PA P S P
Sbjct: 707 PPSPPASPPMSPSAT--------PPPQAPPPLAAPPLQVPPSPPASPPMS-----PSATP 753
Query: 1154 PPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAP 1186
PPR P PL PP LA+ P
Sbjct: 754 PPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPP 786
Score = 56.2 bits (134), Expect = 2e-07
Identities = 78/288 (27%), Positives = 106/288 (36%), Gaps = 49/288 (17%)
Query: 919 PAFTEASCPL-SRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAP---------- 967
P T+AS SR P PP P + P + P + L+P + P +P
Sbjct: 434 PRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALS 493
Query: 968 --------EPEGVAAPPPKNSFNNPAYYVLEGVPHQL-LPPEPPSPARAPVPSATKNKVA 1018
P PP + ++ A L+ P L PP P+ AP P T +
Sbjct: 494 SLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPL 553
Query: 1019 ITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFP-----PPPLPDSAIFLPPSLDPLP 1073
T P L P S T PPP+ P PPP A+ PP L LP
Sbjct: 554 TT---PHL--ETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPP-LQGLP 607
Query: 1074 GPVVRGRGGAEARGPPPPKAHPR---PPL--PPGPSPASTFLGEVASGDDRSCSVLQMAK 1128
P + PPP+A P PPL PP P PAS L +A+ ++ + L +
Sbjct: 608 SPPL------SPLATPPPQAPPXLALPPLQAPPSP-PASPPLSPLATPSPQAPNALAVHL 660
Query: 1129 TLSEVDYAPAGPARSALLP------GPLELQPPRGLPSDYGRPLSFPP 1170
+ P+ P ++ P P P + PS PL PP
Sbjct: 661 LQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP 708
Score = 55.1 bits (131), Expect = 4e-07
Identities = 88/326 (26%), Positives = 114/326 (34%), Gaps = 69/326 (21%)
Query: 869 SMKVRVPTERLGTRERLYEWISIDKDEAG-AKSKAPSVSRGSQEPRSGSRKPAFTEASCP 927
S + R PTE G R+ + E A + PS G Q P S S + T S P
Sbjct: 195 SARPRPPTE--GPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 252
Query: 928 LS---------RLFEEPEKPPPTG----RPP--APPR--AAPREEPLTPRLKPEGAPEPE 970
R P +P P G RPP PPR AAP PL+ P P P
Sbjct: 253 ARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS--SPLATPSPS 310
Query: 971 GVAA---PPPKNSFNN-PAYYVLEGVPHQLLPPEPPSPARAPV--PSATKNKVAITVPAP 1024
G A PPP N+ PA LPP PP P+ PS + T+P+P
Sbjct: 311 GTKARPVPPPDNAATPLPA----------TLPPSPPLATPLPLAPPSPSAPPSLQTLPSP 360
Query: 1025 QLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAE 1084
PP PP + + PPSL +P V +
Sbjct: 361 PA----------------------TPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSP 398
Query: 1085 ARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSA 1144
+ PP PL A+T LG S + +T + + +P+ PA +
Sbjct: 399 SLQAPP------SPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLT-SPSRPASTP 451
Query: 1145 LLPGPLELQPPRGLPSDYGRPLSFPP 1170
P LQ P LP+ S P
Sbjct: 452 --PDSPPLQAPLSLPASPPLQTSLSP 475
Score = 54.3 bits (129), Expect = 7e-07
Identities = 87/349 (24%), Positives = 109/349 (31%), Gaps = 91/349 (26%)
Query: 896 AGAKSKAPSVSRGS---------QEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPP- 945
AGA + P R PR+G + A T + P SR PP +GR
Sbjct: 50 AGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASR-------PPASGRGER 102
Query: 946 APPRAAPREEPLTPRLKPEGAPEP-----------------EGVAAPPPKNSFNNPAYYV 988
APP P++ + G P G A PK S +
Sbjct: 103 APPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSA------L 156
Query: 989 LEGVPHQLLPPEP--PSPARAPVPSATKNKVAITVPAPQLGHHRHPRVG--EGSSSDEES 1044
G P P PSPA A A +V + PAP R P G + SS E
Sbjct: 157 SAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPS-ARPRPPTEGPRKSVSSASEH 215
Query: 1045 GGTLPPPDFPPPPLPDSAIFLPPSLD------PLPGPVVRGRGGAEARGPPPPKAHPRPP 1098
T P P P + P S PL P R G ARG P AHP P
Sbjct: 216 STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPA---RSGPSARGTPRAPAHPSQP 272
Query: 1099 LPPG------------------------------PSPASTFLGEVASGDDRSCSV----- 1123
P G PSP+ T V D+ + +
Sbjct: 273 KPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLP 332
Query: 1124 --LQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGLPSDYGRPLSFPP 1170
+A L +P+ P LP P P + PS P+ PP
Sbjct: 333 PSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPP 381
Score = 53.5 bits (127), Expect = 1e-06
Identities = 78/308 (25%), Positives = 103/308 (33%), Gaps = 51/308 (16%)
Query: 919 PAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPK 978
P + PL P PP P+PP P + P + P AP P PP +
Sbjct: 332 PPSPPLATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAP-PSLQTIPPIQ 390
Query: 979 NSFNNPAYYVLEGVPHQLLPPE---PPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVG 1035
VPH L P PPSP AT + + T+ A PR
Sbjct: 391 -------------VPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQT 437
Query: 1036 EGSSSDEESGGTLPPPDFPP-------PPLPDSAIFLPPSLDPLPGPV----VRGRGGAE 1084
+ S + + PP D PP P P L P++ PL P+ ++
Sbjct: 438 QASLTSPSRPASTPP-DSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLA 496
Query: 1085 ARGPPPPKAHP-RPPL-------PPG--PSPASTFLGEVASGDDRSCSVLQMAKTLSEVD 1134
+ P P + PPL PP PAS + + + LQ A
Sbjct: 497 SHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTP 556
Query: 1135 YAPAGPARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRAS 1194
+ P P P LQ P PS PL+ PPP SI + P L
Sbjct: 557 HLETPPC-----PAPCPLQAP---PS----PLTTPPPETPSSIATPPPQAPPALASPPLQ 604
Query: 1195 GLGEAGMS 1202
GL +S
Sbjct: 605 GLPSPPLS 612
Score = 52.4 bits (124), Expect = 3e-06
Identities = 75/289 (25%), Positives = 97/289 (33%), Gaps = 57/289 (19%)
Query: 856 LSHRGEETGNIR----GSMKVRVPTERLGTRERLYEWISIDKDEAGAKSKAPSVSRGSQE 911
+S G +G R G +R+ E R + E AGA+ + G+
Sbjct: 114 VSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS 173
Query: 912 PRSGSR-KPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPE 970
P R + A TE P +P P+ RP PP PR+ + P P
Sbjct: 174 PAMARRSRAAGTEVGLP---------RPAPSARP-RPPTEGPRKSVSSASEHSTTEPSPA 223
Query: 971 GVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPA-----RAPV-PSATKNKVAITVPAP 1024
P PA L L P P+ RAP PS K K + P
Sbjct: 224 ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPP 283
Query: 1025 QLGHHRH---PRVGEGSSSD---EESGGT----LPPPDFPPPPLPDS------------- 1061
Q+ R P +G SSS GT +PPPD PLP +
Sbjct: 284 QVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPL 343
Query: 1062 ---AIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPAS 1107
+ PPSL LP P PP +A P PP +P S
Sbjct: 344 APPSPSAPPSLQTLPSP----------PATPPSQAPPSMTTPPMQAPPS 382
Score = 45.1 bits (105), Expect = 4e-04
Identities = 66/235 (28%), Positives = 78/235 (33%), Gaps = 76/235 (32%)
Query: 919 PAFTEASCPLSRLFEEPEKPPPTGR------PPAPPRA----APREEPLT--------PR 960
P AS P+S L P + PP PP+PP + APR P PR
Sbjct: 812 PFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPR 871
Query: 961 LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT 1020
L AP P PPP P PS + A + A +
Sbjct: 872 LTLALAPGP-----PPP--------------------PSRSPSSTLSGPDLAGHSSSATS 906
Query: 1021 VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDF-------------PPPPLPDSAIFLPP 1067
P G+ P G +S PPPD P PPL F
Sbjct: 907 TPEELRGYDSGPEGGAAAS---------PPPDAELAACHPAAWSRGPAPPL----AFRGA 953
Query: 1068 SLDPLPGPVVRGRGGAEA-----RGPPPPKAHPRP-PLPPGPSPASTFLGEVASG 1116
PLP P G G A+ P A P P L PGPSP T G+ A+G
Sbjct: 954 PGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSP-GTSGGKAAAG 1007
Score = 35.0 bits (79), Expect = 0.45
Identities = 19/48 (39%), Positives = 25/48 (52%), Gaps = 1/48 (2%)
Query: 134 GEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGLSTV 181
G +P PP + +T + A PS PL P P AP + SAP L T+
Sbjct: 311 GTKARPVPPPDNAATPLPATLPPSPPLATP-LPLAPPSPSAPPSLQTL 357
Score = 32.0 bits (71), Expect = 3.8
Identities = 50/193 (25%), Positives = 63/193 (32%), Gaps = 31/193 (16%)
Query: 996 LLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPP 1055
LL P PP R P P T + + A +G R P GG P P
Sbjct: 24 LLTPRPPGSPRPP-PPVTPAALRVLGAAGAVG--RKPLAERAGG----IGGATIPESAPR 76
Query: 1056 PPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVAS 1115
SA S +P P GRG R PP P P PG + +T G +
Sbjct: 77 AGPTRSA--GTSSRNPASRPPASGRG---ERAPPAKNTSPGPVSSPGRASGTTRPGPLGQ 131
Query: 1116 GDDRSCSVLQMAKTLSEVDYAPAGPARSAL--------------LPGPLELQPPRGLPSD 1161
R + +A+ A P RSAL P P + R ++
Sbjct: 132 KGLRISAEETVAR-----GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTE 186
Query: 1162 YGRPLSFPPPRIR 1174
G P P R R
Sbjct: 187 VGLPRPAPSARPR 199
Score = 31.2 bits (69), Expect = 6.5
Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 8/66 (12%)
Query: 116 PVEGEREPDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSP-----LPAPETPTAPA 170
P + P PP D A+ PP PP + + AP PS+P LP+P P P
Sbjct: 309 PSGTKARPVPPPDNAATPLPATLPPSPPLATPLPL-APPSPSAPPSLQTLPSP--PATPP 365
Query: 171 AESAPN 176
+++ P+
Sbjct: 366 SQAPPS 371
>gi|116284398 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 75.5 bits (184), Expect = 3e-13
Identities = 73/270 (27%), Positives = 102/270 (37%), Gaps = 46/270 (17%)
Query: 935 PEKPPPTGRP----PAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLE 990
P PP GR P P + P P+ G PEP+ PPP+ +
Sbjct: 126 PPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK------ 179
Query: 991 GVPHQLLPPEPPSPARAPVPSATKNKVAITVPA-----------PQLGHHRHPRVGEGSS 1039
P + PP P +P P+ S+ N+ + VP P +R +G GS
Sbjct: 180 --PDSIPPPVPSTPR--PIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSI 235
Query: 1040 SDEESGGTLPPPDFPP-PPLPDSAIFLPPSLDPLPGPVVRGRGGAEARG-PPPPKAHPRP 1097
+ P + PP PP P A+ P P P P V R PPPP + +P
Sbjct: 236 RQSPLSSSSPFSNRPPLPPTPSRALDDKP---PPPPPPVGNRPSIHREAVPPPPPQNNKP 292
Query: 1098 PLPPGPSPASTF----------------LGEVASGDDRSCSVLQMAKTLSEVDYAPAGPA 1141
P+P P P+++ L +SG+D + + Q +LS P
Sbjct: 293 PVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPG 352
Query: 1142 RSALLPGPLELQPPRGLPSDYGRPLSFPPP 1171
RS LP P +PP + GR PPP
Sbjct: 353 RSGPLPPPPSERPPPPVRDPPGRSGPLPPP 382
Score = 58.9 bits (141), Expect = 3e-08
Identities = 68/255 (26%), Positives = 88/255 (34%), Gaps = 70/255 (27%)
Query: 902 APSVSRGSQEPRSGSRKPAF-----TEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEP 956
+P V G ++P G P F T R P + RPP PP
Sbjct: 203 SPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPP-------- 254
Query: 957 LTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNK 1016
TP + P P PPP N P+ + + +PP PP + PVPS +
Sbjct: 255 -TPSRALDDKPPPP----PPPVG--NRPSIH------REAVPPPPPQNNKPPVPSTPRPS 301
Query: 1017 VAITVPAPQLGHHRH--PRVGEGSSSDEESGGTLPPPDF------PPPPLPDSAIFLPPS 1068
+ P P R P + SS ++E+ LP + PP P P + LPP
Sbjct: 302 ASSQAPPPPPPPSRPGPPPLPPSSSGNDETP-RLPQRNLSLSSSTPPLPSPGRSGPLPPP 360
Query: 1069 LDPLPGPVVRGRGGAEARGPPP---------------------------PKAHPRPPLPP 1101
P P VR G PPP P++ PRPPLPP
Sbjct: 361 PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPP 420
Query: 1102 G--------PSPAST 1108
P P ST
Sbjct: 421 DRPSAGAPPPPPPST 435
Score = 42.7 bits (99), Expect = 0.002
Identities = 56/179 (31%), Positives = 65/179 (36%), Gaps = 34/179 (18%)
Query: 998 PPEPPS-PARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPP 1056
P PPS P R PVPS P PQ PR GS PD PP
Sbjct: 140 PFSPPSGPGRFPVPSPGHRSGP---PEPQRNRMPPPRPDVGSK-----------PDSIPP 185
Query: 1057 PLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPP-PKAHPRPPLP-PGPSPASTFLGEVA 1114
P+P + P P+ + RG PP P PR P P P P P G
Sbjct: 186 PVPST-----------PRPI---QSSPHNRGSPPVPGG-PRQPSPGPTPPPFPGNRGTAL 230
Query: 1115 SGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRG-LPSDYGRPLSFPPPR 1172
G S L + S P P+R AL P PP G PS + + PPP+
Sbjct: 231 GGGSIRQSPLSSSSPFSNRPPLPPTPSR-ALDDKPPPPPPPVGNRPSIHREAVPPPPPQ 288
Score = 40.0 bits (92), Expect = 0.014
Identities = 25/61 (40%), Positives = 28/61 (45%), Gaps = 4/61 (6%)
Query: 123 PDPPDDRDASDGEDEKPPLPPRSGSTSISAP----TGPSSPLPAPETPTAPAAESAPNGL 178
P PP +S G DE P LP R+ S S S P G S PLP P + P P G
Sbjct: 316 PGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGR 375
Query: 179 S 179
S
Sbjct: 376 S 376
Score = 35.0 bits (79), Expect = 0.45
Identities = 27/81 (33%), Positives = 32/81 (39%), Gaps = 16/81 (19%)
Query: 114 LLPVEGEREPDPPDDRDASDGEDEKPPLPPRSGSTSISAP---------------TGPSS 158
L P ER P P D G PP R+GSTS + P +GP
Sbjct: 357 LPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRP 416
Query: 159 PLPAPETPTAPAAESAPNGLS 179
PLP P+ P+A A P S
Sbjct: 417 PLP-PDRPSAGAPPPPPPSTS 436
Score = 31.2 bits (69), Expect = 6.5
Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 8/61 (13%)
Query: 121 REPDPPDDRDASDGEDEKPPLPPRSGS------TSISAPTGPSSPLPAPETPTAPAAESA 174
R P PP A D D+ PP PP G+ ++ P ++ P P TP A+ A
Sbjct: 249 RPPLPPTPSRALD--DKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQA 306
Query: 175 P 175
P
Sbjct: 307 P 307
Score = 31.2 bits (69), Expect = 6.5
Identities = 15/53 (28%), Positives = 22/53 (41%)
Query: 123 PDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAP 175
P PP S + PP PP++ + + PS+ AP P P+ P
Sbjct: 267 PPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPP 319
>gi|38373695 WAS/WASL interacting protein family, member 1 [Homo
sapiens]
Length = 503
Score = 75.5 bits (184), Expect = 3e-13
Identities = 73/270 (27%), Positives = 102/270 (37%), Gaps = 46/270 (17%)
Query: 935 PEKPPPTGRP----PAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLE 990
P PP GR P P + P P+ G PEP+ PPP+ +
Sbjct: 126 PPLLPPGGRSTSAKPFSPPSGPGRFPVPSPGHRSGPPEPQRNRMPPPRPDVGSK------ 179
Query: 991 GVPHQLLPPEPPSPARAPVPSATKNKVAITVPA-----------PQLGHHRHPRVGEGSS 1039
P + PP P +P P+ S+ N+ + VP P +R +G GS
Sbjct: 180 --PDSIPPPVPSTPR--PIQSSPHNRGSPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSI 235
Query: 1040 SDEESGGTLPPPDFPP-PPLPDSAIFLPPSLDPLPGPVVRGRGGAEARG-PPPPKAHPRP 1097
+ P + PP PP P A+ P P P P V R PPPP + +P
Sbjct: 236 RQSPLSSSSPFSNRPPLPPTPSRALDDKP---PPPPPPVGNRPSIHREAVPPPPPQNNKP 292
Query: 1098 PLPPGPSPASTF----------------LGEVASGDDRSCSVLQMAKTLSEVDYAPAGPA 1141
P+P P P+++ L +SG+D + + Q +LS P
Sbjct: 293 PVPSTPRPSASSQAPPPPPPPSRPGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPG 352
Query: 1142 RSALLPGPLELQPPRGLPSDYGRPLSFPPP 1171
RS LP P +PP + GR PPP
Sbjct: 353 RSGPLPPPPSERPPPPVRDPPGRSGPLPPP 382
Score = 58.9 bits (141), Expect = 3e-08
Identities = 68/255 (26%), Positives = 88/255 (34%), Gaps = 70/255 (27%)
Query: 902 APSVSRGSQEPRSGSRKPAF-----TEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEP 956
+P V G ++P G P F T R P + RPP PP
Sbjct: 203 SPPVPGGPRQPSPGPTPPPFPGNRGTALGGGSIRQSPLSSSSPFSNRPPLPP-------- 254
Query: 957 LTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNK 1016
TP + P P PPP N P+ + + +PP PP + PVPS +
Sbjct: 255 -TPSRALDDKPPPP----PPPVG--NRPSIH------REAVPPPPPQNNKPPVPSTPRPS 301
Query: 1017 VAITVPAPQLGHHRH--PRVGEGSSSDEESGGTLPPPDF------PPPPLPDSAIFLPPS 1068
+ P P R P + SS ++E+ LP + PP P P + LPP
Sbjct: 302 ASSQAPPPPPPPSRPGPPPLPPSSSGNDETP-RLPQRNLSLSSSTPPLPSPGRSGPLPPP 360
Query: 1069 LDPLPGPVVRGRGGAEARGPPP---------------------------PKAHPRPPLPP 1101
P P VR G PPP P++ PRPPLPP
Sbjct: 361 PSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRPPLPP 420
Query: 1102 G--------PSPAST 1108
P P ST
Sbjct: 421 DRPSAGAPPPPPPST 435
Score = 42.7 bits (99), Expect = 0.002
Identities = 56/179 (31%), Positives = 65/179 (36%), Gaps = 34/179 (18%)
Query: 998 PPEPPS-PARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPP 1056
P PPS P R PVPS P PQ PR GS PD PP
Sbjct: 140 PFSPPSGPGRFPVPSPGHRSGP---PEPQRNRMPPPRPDVGSK-----------PDSIPP 185
Query: 1057 PLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPP-PKAHPRPPLP-PGPSPASTFLGEVA 1114
P+P + P P+ + RG PP P PR P P P P P G
Sbjct: 186 PVPST-----------PRPI---QSSPHNRGSPPVPGG-PRQPSPGPTPPPFPGNRGTAL 230
Query: 1115 SGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRG-LPSDYGRPLSFPPPR 1172
G S L + S P P+R AL P PP G PS + + PPP+
Sbjct: 231 GGGSIRQSPLSSSSPFSNRPPLPPTPSR-ALDDKPPPPPPPVGNRPSIHREAVPPPPPQ 288
Score = 40.0 bits (92), Expect = 0.014
Identities = 25/61 (40%), Positives = 28/61 (45%), Gaps = 4/61 (6%)
Query: 123 PDPPDDRDASDGEDEKPPLPPRSGSTSISAP----TGPSSPLPAPETPTAPAAESAPNGL 178
P PP +S G DE P LP R+ S S S P G S PLP P + P P G
Sbjct: 316 PGPPPLPPSSSGNDETPRLPQRNLSLSSSTPPLPSPGRSGPLPPPPSERPPPPVRDPPGR 375
Query: 179 S 179
S
Sbjct: 376 S 376
Score = 35.0 bits (79), Expect = 0.45
Identities = 27/81 (33%), Positives = 32/81 (39%), Gaps = 16/81 (19%)
Query: 114 LLPVEGEREPDPPDDRDASDGEDEKPPLPPRSGSTSISAP---------------TGPSS 158
L P ER P P D G PP R+GSTS + P +GP
Sbjct: 357 LPPPPSERPPPPVRDPPGRSGPLPPPPPVSRNGSTSRALPATPQLPSRSGVDSPRSGPRP 416
Query: 159 PLPAPETPTAPAAESAPNGLS 179
PLP P+ P+A A P S
Sbjct: 417 PLP-PDRPSAGAPPPPPPSTS 436
Score = 31.2 bits (69), Expect = 6.5
Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 8/61 (13%)
Query: 121 REPDPPDDRDASDGEDEKPPLPPRSGS------TSISAPTGPSSPLPAPETPTAPAAESA 174
R P PP A D D+ PP PP G+ ++ P ++ P P TP A+ A
Sbjct: 249 RPPLPPTPSRALD--DKPPPPPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQA 306
Query: 175 P 175
P
Sbjct: 307 P 307
Score = 31.2 bits (69), Expect = 6.5
Identities = 15/53 (28%), Positives = 22/53 (41%)
Query: 123 PDPPDDRDASDGEDEKPPLPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAP 175
P PP S + PP PP++ + + PS+ AP P P+ P
Sbjct: 267 PPPPVGNRPSIHREAVPPPPPQNNKPPVPSTPRPSASSQAPPPPPPPSRPGPP 319
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 74.7 bits (182), Expect = 5e-13
Identities = 97/359 (27%), Positives = 125/359 (34%), Gaps = 49/359 (13%)
Query: 869 SMKVRVPTERLGTRERLYEWISIDKDEAG-AKSKAPSVSRGSQEPRSGSRKPAFTEASCP 927
S + R PTE G R+ + E A + PS G Q P S S + T S P
Sbjct: 186 SARPRPPTE--GPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP 243
Query: 928 LS---------RLFEEPEKPPPTG----RPP--APPR--AAPREEPLT--PRLKPEGAPE 968
R P +P P G RPP PPR AAP PL+ P P +
Sbjct: 244 ARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAP 303
Query: 969 PEGVAAP-----------PPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKV 1017
P A P PP + + L+ H LP P SP P P A
Sbjct: 304 PSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQAT-HSFLPSPPLSPLATPPPQAPPALA 362
Query: 1018 AITVPAPQLGHHRHPRVGEGSSSDEESGGT----LPPPDFPPPPLPDSAIFLPPSLDPLP 1073
+ AP P + S + L P PPP P A F PP+ P+
Sbjct: 363 LPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 422
Query: 1074 GPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEV 1133
+ PP + P PP P SP++T + + LQ+AK +
Sbjct: 423 PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSAT--PPPQAPPPLAAPPLQLAKPPPQA 480
Query: 1134 DYAPAGPARSAL------LPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAP 1186
A A P AL PG P LP PL+ PPP+ + L + P
Sbjct: 481 PPALATPPLQALPSPPASFPGQAPFSPSASLPMS---PLATPPPQAPPVLAAPLLQVPP 536
Score = 71.2 bits (173), Expect = 6e-12
Identities = 88/284 (30%), Positives = 105/284 (36%), Gaps = 53/284 (18%)
Query: 909 SQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPP---APPRAAPREEPLTPRLKPEG 965
S P + P AS P+S P PP+ PP APP P P +P + P
Sbjct: 402 SPPPSPPVQAPFSPPASPPVS-----PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA 456
Query: 966 APEPEG---VAAPPPKNSFNNP-AYYVLEGVPHQLLPPEPPS-PARAPV-PSATKNKVAI 1019
P P+ +AAPP + + P A L P Q LP P S P +AP PSA+ +
Sbjct: 457 TPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 516
Query: 1020 TVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRG 1079
P PQ P V P PP P P S P P PGP
Sbjct: 517 ATPPPQA-----PPVLAA-----------PLLQVPPSP-PASPTLQAPRRPPTPGP---- 555
Query: 1080 RGGAEARGPPPPKA-HPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPA 1138
GP A P PP PP SP+ST G +G S S + L D P
Sbjct: 556 --DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAG--HSSSATSTPEELRGYDSGPE 611
Query: 1139 GPARSALLPGPLEL------------QPPRGLPSDYGRPLSFPP 1170
G A +A P EL PP G PL +PP
Sbjct: 612 GGA-AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPP 654
Score = 61.6 bits (148), Expect = 5e-09
Identities = 92/361 (25%), Positives = 122/361 (33%), Gaps = 67/361 (18%)
Query: 856 LSHRGEETGNIR----GSMKVRVPTERLGTRERLYEWISIDKDEAGAKSKAPSVSRGSQE 911
+S G +G R G +R+ E R + E AGA+ + G+
Sbjct: 105 VSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS 164
Query: 912 PRSGSR-KPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPE 970
P R + A TE P +P P+ RP PP PR+ + P P
Sbjct: 165 PAMARRSRAAGTEVGLP---------RPAPSARP-RPPTEGPRKSVSSASEHSTTEPSPA 214
Query: 971 GVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPA-----RAPV-PSATKNKVAITVPAP 1024
P PA L L P P+ RAP PS K K + P
Sbjct: 215 ARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPP 274
Query: 1025 QLGHHRH---PRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRG 1081
Q+ R P +G SSS + P P PP P PPSL LP P
Sbjct: 275 QVTPPRKDAAPALGPLSSSPLAT----PSPSAPPSP------SAPPSLQTLPSPPATPPS 324
Query: 1082 GAEAR---------------------GPPPPKAHPR---PPL--PPGPSPASTFLGEVAS 1115
A PPP+A P PPL PP P PAS L +A+
Sbjct: 325 QATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSP-PASPPLSPLAT 383
Query: 1116 GDDRSCSVLQMAKTLSEVDYAPAGPARSALLP------GPLELQPPRGLPSDYGRPLSFP 1169
++ + L + + P+ P ++ P P P + PS PL P
Sbjct: 384 PSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVP 443
Query: 1170 P 1170
P
Sbjct: 444 P 444
Score = 45.1 bits (105), Expect = 4e-04
Identities = 66/235 (28%), Positives = 78/235 (33%), Gaps = 76/235 (32%)
Query: 919 PAFTEASCPLSRLFEEPEKPPPTGR------PPAPPRA----APREEPLT--------PR 960
P AS P+S L P + PP PP+PP + APR P PR
Sbjct: 504 PFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPR 563
Query: 961 LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT 1020
L AP P PPP P PS + A + A +
Sbjct: 564 LTLALAPGP-----PPP--------------------PSRSPSSTLSGPDLAGHSSSATS 598
Query: 1021 VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDF-------------PPPPLPDSAIFLPP 1067
P G+ P G +S PPPD P PPL F
Sbjct: 599 TPEELRGYDSGPEGGAAAS---------PPPDAELAACHPAAWSRGPAPPL----AFRGA 645
Query: 1068 SLDPLPGPVVRGRGGAEA-----RGPPPPKAHPRP-PLPPGPSPASTFLGEVASG 1116
PLP P G G A+ P A P P L PGPSP T G+ A+G
Sbjct: 646 PGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSP-GTSGGKAAAG 699
Score = 35.4 bits (80), Expect = 0.35
Identities = 56/224 (25%), Positives = 70/224 (31%), Gaps = 53/224 (23%)
Query: 902 APSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAP------REE 955
+P S Q PR T S P L P PPP R P+ + P
Sbjct: 537 SPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSA 596
Query: 956 PLTPR--LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPS-A 1012
TP + PE A+PPP +L P + +R P P A
Sbjct: 597 TSTPEELRGYDSGPEGGAAASPPP---------------DAELAACHPAAWSRGPAPPLA 641
Query: 1013 TKNKVAITVPAPQLGHHRHPRVGEGSSSD-----EESGGTLPPPDFPPPPLPDSAIFLPP 1067
+ +P P P G GS+ E G P+SA P
Sbjct: 642 FRGAPGAPLPWP-------PATGPGSADGLCTIYETEG-------------PESATPAPG 681
Query: 1068 SLDPLPGPVVRGRGGAEARGPPPPKAHPRP----PLPPGPSPAS 1107
+LDP P P G A G P+ LP G AS
Sbjct: 682 ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQAS 725
Score = 31.2 bits (69), Expect = 6.5
Identities = 30/99 (30%), Positives = 37/99 (37%), Gaps = 8/99 (8%)
Query: 996 LLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRV----GEGSSSDEESGGTLPPP 1051
LL P PP R P P T + + A +G R P G G ++ ES P
Sbjct: 24 LLTPRPPGSPRPP-PPVTPAALRVLGAAGAVG--RKPLAERAGGIGGATIPESAPRAGPT 80
Query: 1052 DFPPPPLPDSAIFLPPSLDPLPGPVVR-GRGGAEARGPP 1089
PP PP+ + PGPV GR R P
Sbjct: 81 RTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGP 119
Score = 30.8 bits (68), Expect = 8.5
Identities = 22/63 (34%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query: 121 REPDPPDDRDASDGEDEKPP--LPPRSGSTSISAPTGPSSPLPAPETPTAPAAESAPNGL 178
R P P + +PP PPR + P SSPL P +P+AP + SAP L
Sbjct: 255 RAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLS-SSPLATP-SPSAPPSPSAPPSL 312
Query: 179 STV 181
T+
Sbjct: 313 QTL 315
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 74.7 bits (182), Expect = 5e-13
Identities = 82/281 (29%), Positives = 109/281 (38%), Gaps = 48/281 (17%)
Query: 900 SKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRP---PAPPRA---APR 953
S +P +R + P+ P+ A P + P+ P T P P PP A +P+
Sbjct: 915 SSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPK 974
Query: 954 EEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEG--VPHQLLPPEPP-SPARAPVP 1010
P TP P+GAP P P PK PA +G P + PP P SPA P P
Sbjct: 975 GGPATP--SPKGAPTPPAATPPSPK---GGPATPSPKGAPTPPAVTPPSPKGSPAATPFP 1029
Query: 1011 SATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLD 1070
A T P+P+ G + +G+ + TLP P P PP+
Sbjct: 1030 KGASTPPAATPPSPK-GSPAATPLPKGAPT--TPAATLPSPKGGPATPSLKGAPTPPAAT 1086
Query: 1071 PLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTL 1130
P P P +GG P PK P PP PSP G +A+ +
Sbjct: 1087 P-PSP----KGGP---ATPSPKGAPMPPAATPPSPK----GGLATPPHKG---------- 1124
Query: 1131 SEVDYAPAGPARSALLP-GPLELQPPRGLPSDYGRPLSFPP 1170
AP PA + P G L PP+G P+ P + PP
Sbjct: 1125 -----APTTPAATPPSPKGGLATPPPKGAPT---TPAATPP 1157
Score = 73.2 bits (178), Expect = 1e-12
Identities = 77/281 (27%), Positives = 94/281 (33%), Gaps = 32/281 (11%)
Query: 898 AKSKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPL 957
A +P + P+ PA T S P L PPP G P P P +
Sbjct: 1131 ATPPSPKGGLATPPPKGAPTTPAATPPS-PKGGL----ATPPPKGAPTTPAATPPSPKGG 1185
Query: 958 TPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKV 1017
P+GAP P PK P+ P PP P P P
Sbjct: 1186 LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTP-AATPPSPKGGLATPSPKGAPTTP 1244
Query: 1018 AITVPAPQLGHHRHPRVG----EGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLP 1073
A T P+P+ G P G ++ GG PP P+ A+ PPS P
Sbjct: 1245 AATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPH---KGAPNPAVVTPPS--PKG 1299
Query: 1074 GPVVRGRGGA---EARGPPPPKAHPRPPLPPG-PSPASTFLGEVASGDDRSCSVLQMAKT 1129
GP GA A PP PK P P P G P+P + V + L
Sbjct: 1300 GPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPA-----VTPPSPKGTPTLPATTP 1354
Query: 1130 LSEVDYAPAGPARSALLPGPLELQPPRGLPSDYGRPLSFPP 1170
S+ GP + GP PP PS G P PP
Sbjct: 1355 SSK-----GGPTTPSSKEGP---TPPAATPSHKGGPAMTPP 1387
Score = 67.0 bits (162), Expect = 1e-10
Identities = 80/302 (26%), Positives = 105/302 (34%), Gaps = 54/302 (17%)
Query: 903 PSVSRG-SQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRL 961
PS+ G + P G+ PA P P K PT PPA +P+ P TP
Sbjct: 1272 PSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPT--PPAATPPSPKGSPGTP-- 1327
Query: 962 KPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSAT----KNKV 1017
P+GAP P V P PK + PA P P PS P P A K
Sbjct: 1328 PPKGAPTPPAVTPPSPKGTPTLPA-----TTPSSKGGPTTPSSKEGPTPPAATPSHKGGP 1382
Query: 1018 AITVPAPQLGH---------------HRHPRVGEGSSSDEESGGTLPPPDFPPPPL-PDS 1061
A+T P+P+ G P+ + E T D PP + P S
Sbjct: 1383 AMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAVTPVS 1442
Query: 1062 AIFLPPSLDPLPGPVV---RGRGGAEARGPPPPKAHPRP------------PLPPGPSPA 1106
P + P GP +G A PP PK P P P P P A
Sbjct: 1443 LKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGA 1502
Query: 1107 STFLGEV--------ASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGL 1158
T + A+ R + A LS+ A P + AL+P + + P+
Sbjct: 1503 PTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAP-KEALIPPAMTVPSPKKT 1561
Query: 1159 PS 1160
P+
Sbjct: 1562 PA 1563
Score = 63.2 bits (152), Expect = 2e-09
Identities = 81/307 (26%), Positives = 118/307 (38%), Gaps = 40/307 (13%)
Query: 902 APSVSRGSQEPRSGSRKPAFTEASCPLS---RLFEEPEKPPPTGRPPAPPRAAPREEPLT 958
+P + P+ P+ EAS P + ++ P PPA +P+E P
Sbjct: 1557 SPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPTP 1616
Query: 959 PRLKPEGAPEPE-GVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPAR------APVPS 1011
P + P P PE G A P PK + +P V L P SPA A VP
Sbjct: 1617 PAVTP---PSPEKGPATPAPKGTPTSPP------VTPSSLKDSPTSPASVTCKMGATVPQ 1667
Query: 1012 ATKN----------KVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDS 1061
A+K K + PAP+ +G + + S + PP P P +
Sbjct: 1668 ASKGLPAKKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATS--PPICPDPSAKNG 1725
Query: 1062 AIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSC 1121
+ ++ P P V+ A+G + P+ PL P S AST L A
Sbjct: 1726 SKGPLSTVAPAPLLPVQKDSSKTAKGKDASHS-PKGPLAPPESKASTPLTAAAFE----- 1779
Query: 1122 SVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRG--LPSDYGRPLSFPPPRIRESIQE 1179
VL ++ S V AP+ P L P P+ PP+ LPS G L P + + ++
Sbjct: 1780 KVLPKPESAS-VSAAPSPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKPLAPADED 1838
Query: 1180 DLAEEAP 1186
+L P
Sbjct: 1839 ELLPLIP 1845
Score = 59.3 bits (142), Expect = 2e-08
Identities = 74/301 (24%), Positives = 101/301 (33%), Gaps = 37/301 (12%)
Query: 902 APSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEK-----PPPTGRPPAPPRAAPREEP 956
AP S + P S A + L+ L + P P T RPP +A + P
Sbjct: 761 APVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTP 820
Query: 957 LTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSA---- 1012
+ P E A+ P+NS + + + P P PPSP AP PSA
Sbjct: 821 IGNLSSPVSPVE----ASFLPENSLS---FQGSKDSPATTHSPTPPSPKGAPTPSAVTPL 873
Query: 1013 -----------TKNKVAITVPAPQLG-----HHRHPRVGEGSSSDEESGGTLPPPDFPPP 1056
T + +P P+ G + P + SSS +++ T P P
Sbjct: 874 SPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPAS 933
Query: 1057 PLPDSAIFLPPSLDPLP--GPVVRGRGGA---EARGPPPPKAHPRPPLPPGPSPASTFLG 1111
P P A P + P P GP A A PP PK P P P G
Sbjct: 934 PSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGAPTPPAATP 993
Query: 1112 EVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGLPSDYGRPLSFPPP 1171
G + S + +P G + P P PS G P + P P
Sbjct: 994 PSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLP 1053
Query: 1172 R 1172
+
Sbjct: 1054 K 1054
Score = 44.3 bits (103), Expect = 7e-04
Identities = 67/290 (23%), Positives = 97/290 (33%), Gaps = 39/290 (13%)
Query: 902 APSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTG---RPPAPPRAAPREEPLT 958
AP S P+ PA A + + P++ P T R P P A +
Sbjct: 1480 APKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTP 1539
Query: 959 PRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVA 1018
L P+ A P + P PK + P P+P AP ++K A
Sbjct: 1540 ATLAPKEALIPPAMTVPSPKKT------------------PAIPTPKEAPATPSSKE--A 1579
Query: 1019 ITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPP--LPDSAIFLPPSLDPLPGPV 1076
+ PA P +G+ S +E +PP P P P PPS P GP
Sbjct: 1580 SSPPAVT------PSTYKGAPSPKEL--LIPPAVTSPSPKEAPTPPAVTPPS--PEKGPA 1629
Query: 1077 VRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYA 1136
G P P + P P+ + +G + + L EV A
Sbjct: 1630 TPAPKGTPTSPPVTPSS--LKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVA 1687
Query: 1137 PAGPARSALLPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLAEEAP 1186
PA P + ++ P P S P+ P P + + L+ AP
Sbjct: 1688 PA-PESTPIITAPTRKGPQTKKSSATSPPIC-PDPSAKNGSKGPLSTVAP 1735
Score = 37.4 bits (85), Expect = 0.091
Identities = 38/157 (24%), Positives = 59/157 (37%), Gaps = 10/157 (6%)
Query: 900 SKAPSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTP 959
SK S P+ G P ++AS PL+ E P P + + P PL P
Sbjct: 1746 SKTAKGKDASHSPK-GPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAP 1804
Query: 960 RLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVP-------SA 1012
P P+ + + + P +P+ + +LLP PP P VP
Sbjct: 1805 SPVPTLPPKQQFLPSSPGL-VLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMP 1863
Query: 1013 TKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLP 1049
T I VP P + +GS ++ +S ++P
Sbjct: 1864 TPKSAGIPVPTPS-AKQPVTKNNKGSGTESDSDESVP 1899
Score = 33.9 bits (76), Expect = 1.0
Identities = 72/313 (23%), Positives = 107/313 (34%), Gaps = 61/313 (19%)
Query: 861 EETGNIRGSMKVRVPTER-LGTRERLYEWISIDKDEAGAKSK-----------APSVSRG 908
E+ N+ S+ V+ PT++ L T E +AG +K AP S
Sbjct: 513 EDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPS 572
Query: 909 SQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPE 968
Q S P EA+ L E P P G+P + + +K +
Sbjct: 573 FQSTSSSPEIPLSPEATLAKKSLGE----PLPIGKPASSMTSPLGVNSSASVIKTDSYAG 628
Query: 969 PEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAP---- 1024
P+ A P K+S P P E PA +A T +P
Sbjct: 629 PDS-AGPLLKSSLITPTVAAF--------PLESADPAGVAPTTAKGTSTYTTTASPFLEG 679
Query: 1025 --QLGHHRHPRVGEGSSSDEESGGTLP-----PPDFPPPPLPDSAIFLPPSLDPLPGPVV 1077
L HP V EG+ + TLP + P P P + + PL V+
Sbjct: 680 TVSLAPKNHP-VKEGTLT------TLPLVPTASENCPVAPSPQN------TCAPLATLVL 726
Query: 1078 RGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAP 1137
P PK+ P P LPP +P T + G + ++ +A + E
Sbjct: 727 ---------APEIPKSVPSPSLPPAGTPPGT---KKVDGISHTSALAPVASSPKECPTED 774
Query: 1138 AGPARSALLPGPL 1150
+G + +A G L
Sbjct: 775 SGASATASSKGTL 787
Score = 31.6 bits (70), Expect = 5.0
Identities = 70/275 (25%), Positives = 99/275 (36%), Gaps = 62/275 (22%)
Query: 933 EEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGV 992
E E P T + P+A P++ L A G PPP +PA
Sbjct: 4 EATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPP----CSPA------- 52
Query: 993 PHQLLPPEPPSPARAPVPS-ATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLP-P 1050
P Q P + +P PS +T + VP PQ SS GT P
Sbjct: 53 PQQC--PLSAANQASPFPSPSTIASTPLEVPFPQ-----------SSSGTALPLGTAPEA 99
Query: 1051 PDFPP----PPLPDSAIFLPPSLDPLPGPVVRGRGGAEAR----GPPPPKAHPRPPLPPG 1102
P F P PP+ +A+ L P+ P ++G + A P PP
Sbjct: 100 PTFLPNLIGPPISPAALAL---ASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPN 156
Query: 1103 --PSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQP-PRGLP 1159
SP S + E S SV+ ++ + AP+ P ++ L P E+ P P+G P
Sbjct: 157 LLTSPPSVAVAE-------SGSVITLSAPI-----APSEP-KTNLNKVPSEVVPNPKGTP 203
Query: 1160 SDYGRPLSFPPPRIRESIQEDLAEEAPCLQGGRAS 1194
S PP I ++ +Q G AS
Sbjct: 204 S---------PPCIVSTVPYHCVTPMASIQSGVAS 229
Score = 30.8 bits (68), Expect = 8.5
Identities = 68/261 (26%), Positives = 94/261 (36%), Gaps = 63/261 (24%)
Query: 937 KPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAPP-----PKNSFNN--PAYYVL 989
+P PT PP P AP++ PL+ + P P +A+ P P++S P
Sbjct: 40 QPGPTLPPPCSP--APQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAP 97
Query: 990 EG---VPHQLLPPEPP------SPARAPVPSATKNK------VAITVPAPQLGHHRHPRV 1034
E +P+ + PP P SP AP T + VA+ + Q P +
Sbjct: 98 EAPTFLPNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNL 157
Query: 1035 --GEGSSSDEESGG--TLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPP 1090
S + ESG TL P P P +L+ +P VV P
Sbjct: 158 LTSPPSVAVAESGSVITLSAPIAPSEP--------KTNLNKVPSEVV-----------PN 198
Query: 1091 PKAHPRPPLPPGPSP-------ASTFLGEVASGDDRSCSVLQMAK------TLSEVDYAP 1137
PK P PP P AS G + + L +A T+S V +P
Sbjct: 199 PKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLISP 258
Query: 1138 AGPARSALLPGPLELQPPRGL 1158
P S L GP + PP L
Sbjct: 259 QNPG-SLSLKGP--VSPPAAL 276
>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
Length = 416
Score = 73.2 bits (178), Expect = 1e-12
Identities = 79/294 (26%), Positives = 109/294 (37%), Gaps = 62/294 (21%)
Query: 894 DEAGAKSKAPSVSRGSQE--PRSGSRKPAFTEASCPLSRLFEEPEKPPPTG----RPPAP 947
+E ++ ++PS+ G+ + P G KP S P +P+ PPP G + P P
Sbjct: 20 NEDVSQEESPSLIAGNPQGAPPQGGNKPQ-GPPSPP-----GKPQGPPPQGGNQPQGPPP 73
Query: 948 PRAAPREEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARA 1007
P P+ P KP+G P P PPP+ + P PP +
Sbjct: 74 PPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSRS-------------PRSPPGKPQG 120
Query: 1008 PVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFP--PPPLPDS---A 1062
P P P P G + P G+ PPP P PPP D+ +
Sbjct: 121 PPPQGGNQPQG---PPPPPGKPQGPPPQGGNKPQGP-----PPPGKPQGPPPQGDNKSRS 172
Query: 1063 IFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPP------LPPGPSPASTFLGEVASG 1116
PP P P +GG + +GPPPP P+ P P GP P G G
Sbjct: 173 SRSPPGKPQGPPP----QGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQG 228
Query: 1117 DDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGLPSDYGRPLSFPP 1170
D++S S +P G + P P P+G P G+P PP
Sbjct: 229 DNKSQSA-----------RSPPGKPQG---PPPQGGNQPQGPPPPPGKPQGPPP 268
Score = 67.4 bits (163), Expect = 8e-11
Identities = 70/252 (27%), Positives = 94/252 (37%), Gaps = 53/252 (21%)
Query: 934 EPEKPPPTG----RPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVL 989
+P+ PPP G + P PP P+ P KP+G P P PPP+ + +
Sbjct: 117 KPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSP 176
Query: 990 EGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLP 1049
G P Q PP+ + + P P K + P PQ G+ P
Sbjct: 177 PGKP-QGPPPQGGNQPQGPPPPPGKPQ----GPPPQGGNKPQGP---------------P 216
Query: 1050 PPDFP--PPPLPDS---AIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPP------ 1098
PP P PPP D+ + PP P P +GG + +GPPPP P+ P
Sbjct: 217 PPGKPQGPPPQGDNKSQSARSPPGKPQGPPP----QGGNQPQGPPPPPGKPQGPPPQGGN 272
Query: 1099 LPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGL 1158
P GP P G G +S S +P G + P P P+G
Sbjct: 273 KPQGPPPPGKPQGPPPQGGSKSRS-----------SRSPPGKPQG---PPPQGGNQPQGP 318
Query: 1159 PSDYGRPLSFPP 1170
P G+P PP
Sbjct: 319 PPPPGKPQGPPP 330
Score = 62.8 bits (151), Expect = 2e-09
Identities = 76/272 (27%), Positives = 98/272 (36%), Gaps = 64/272 (23%)
Query: 934 EPEKPPPTG----RPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPKNSFNNPAYYVL 989
+P+ PPP G + P PP P+ P KP+G P P PPP+ + +
Sbjct: 179 KPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSP 238
Query: 990 EGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLP 1049
G P Q PP+ + + P P K + P PQ G+ P
Sbjct: 239 PGKP-QGPPPQGGNQPQGPPPPPGKPQ----GPPPQGGNKPQGP---------------P 278
Query: 1050 PPDFP--PPPLPDS---AIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPP------ 1098
PP P PPP S + PP P P +GG + +GPPPP P+ P
Sbjct: 279 PPGKPQGPPPQGGSKSRSSRSPPGKPQGPPP----QGGNQPQGPPPPPGKPQGPPPQGGN 334
Query: 1099 LPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGL 1158
P GP P G G +S S ARS PG P+G
Sbjct: 335 KPQGPPPPGKPQGPPPQGGSKSRS------------------ARSP--PG-----KPQGP 369
Query: 1159 PSDYGRPLSFPPPRIRESIQEDLAEEAPCLQG 1190
P G PPP + Q+ A A QG
Sbjct: 370 PQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQG 401
Score = 43.5 bits (101), Expect = 0.001
Identities = 48/203 (23%), Positives = 65/203 (32%), Gaps = 22/203 (10%)
Query: 907 RGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGA 966
+G + +S P + P + PPP PP+ + + P KP+G
Sbjct: 227 QGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGP 286
Query: 967 PEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQL 1026
P G + ++ P +G PP PP + P P P P
Sbjct: 287 PPQGGSKSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQG--PPPPGK 344
Query: 1027 GHHRHPRVGEGSSSDEESGGTL--PP------PDFPPPPLPDSAIFLPPSLDPLPGPVVR 1078
P+ G S S G PP P PPPP + P P P
Sbjct: 345 PQGPPPQGGSKSRSARSPPGKPQGPPQQEGNNPQGPPPPAGGNP--QQPQAPPAGQP--- 399
Query: 1079 GRGGAEARGPPPPKAHPRPPLPP 1101
+GPP P RP PP
Sbjct: 400 -------QGPPRPPQGGRPSRPP 415
>gi|41349482 proline-rich protein BstNI subfamily 1 isoform 1
preproprotein [Homo sapiens]
Length = 331
Score = 72.8 bits (177), Expect = 2e-12
Identities = 90/332 (27%), Positives = 128/332 (38%), Gaps = 70/332 (21%)
Query: 894 DEAGAKSKAPSVSRGSQE---PRSGSRK----PAFTEASCPLSRLFEEPEKPPPTGRPPA 946
+E ++ ++PS+ G+ + P+ G++ P + P + +P+ PPP G+P
Sbjct: 20 NEDVSQEESPSLIAGNPQGPSPQGGNKPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQG 79
Query: 947 PPRAAPREE-PLTPRLKPEGAP-----EPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPE 1000
PP + P +P KP+G P +P+G PP K P +G PP
Sbjct: 80 PPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP-----QGGNRPQGPP- 133
Query: 1001 PPSPARAPVPSATKNKVAITVPA------PQLGHHRH---PRVGEGSSSDEESGGTL--- 1048
PP + P P K++ + P PQ G+ P G+ + G
Sbjct: 134 PPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGP 193
Query: 1049 PPPDFP--PPPLPDSAIFL--PPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPP------ 1098
PPP P PPP D + PP P P +GG + +GPPPP P+ P
Sbjct: 194 PPPGKPQGPPPQGDKSRSSQSPPGKPQGPPP----QGGNQPQGPPPPPGKPQGPPPQGGN 249
Query: 1099 LPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGL 1158
P GP P G A G +S S ARS PG P+G
Sbjct: 250 KPQGPPPPGKPQGPPAQGGSKSQS------------------ARSP--PG-----KPQGP 284
Query: 1159 PSDYGRPLSFPPPRIRESIQEDLAEEAPCLQG 1190
P G PPP + Q+ A A QG
Sbjct: 285 PQQEGNNPQGPPPPAGGNPQQPQAPPAGQPQG 316
Score = 54.7 bits (130), Expect = 6e-07
Identities = 57/218 (26%), Positives = 83/218 (38%), Gaps = 45/218 (20%)
Query: 897 GAKSKAPSVSRGSQE---PRSGSRK----PAFTEASCPLSRLFEEPEKPPPTGRPPAPPR 949
G KS++P G + P+ G++ P + P + ++P+ PPP G+P PP
Sbjct: 145 GDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGKKPQGPPPPGKPQGPPP 204
Query: 950 AAPREEPL-TPRLKPEGAP-----EPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPS 1003
+ +P KP+G P +P+G PP K P +G PP P
Sbjct: 205 QGDKSRSSQSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPP-----QGGNKPQGPPPPGK 259
Query: 1004 PARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAI 1063
P P +K++ A + P G P EG++ P PPPP +
Sbjct: 260 PQGPPAQGGSKSQSARSPPGKPQG----PPQQEGNN-----------PQGPPPPAGGNP- 303
Query: 1064 FLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPP 1101
P P P +GPP P RP PP
Sbjct: 304 -QQPQAPPAGQP----------QGPPRPPQGGRPSRPP 330
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 855
Score = 71.2 bits (173), Expect = 6e-12
Identities = 88/284 (30%), Positives = 105/284 (36%), Gaps = 53/284 (18%)
Query: 909 SQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPP---APPRAAPREEPLTPRLKPEG 965
S P + P AS P+S P PP+ PP APP P P +P + P
Sbjct: 441 SPPPSPPVQAPFSPPASPPVS-----PSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSA 495
Query: 966 APEPEG---VAAPPPKNSFNNP-AYYVLEGVPHQLLPPEPPS-PARAPV-PSATKNKVAI 1019
P P+ +AAPP + + P A L P Q LP P S P +AP PSA+ +
Sbjct: 496 TPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPL 555
Query: 1020 TVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRG 1079
P PQ P V P PP P P S P P PGP
Sbjct: 556 ATPPPQA-----PPVLAA-----------PLLQVPPSP-PASPTLQAPRRPPTPGP---- 594
Query: 1080 RGGAEARGPPPPKA-HPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPA 1138
GP A P PP PP SP+ST G +G S S + L D P
Sbjct: 595 --DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAG--HSSSATSTPEELRGYDSGPE 650
Query: 1139 GPARSALLPGPLEL------------QPPRGLPSDYGRPLSFPP 1170
G A +A P EL PP G PL +PP
Sbjct: 651 GGA-AASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPP 693
Score = 65.9 bits (159), Expect = 2e-10
Identities = 77/304 (25%), Positives = 109/304 (35%), Gaps = 55/304 (18%)
Query: 902 APSVSRGSQEPRSGSRKPAFTEASC----PLSRLFEEPEKPPPTGRPPAPPRAAPREEPL 957
+PS + SQ P + P + +C PL P PP P+PP P +
Sbjct: 308 SPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATT 367
Query: 958 T---PRLKPEGA----PEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPP--EPPSPARAP 1008
+ P L+ + P +A PPP + P LPP PPSP +P
Sbjct: 368 SLGSPTLQATHSFLPSPPLSPLATPPP------------QAPPALALPPLQAPPSPPASP 415
Query: 1009 VPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLPPS 1068
S + P+PQ + + + L P PPP P A F PP+
Sbjct: 416 PLSP------LATPSPQ-------------APNALAVHLLQAPFSPPPSPPVQAPFSPPA 456
Query: 1069 LDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAK 1128
P+ + PP + P PP P SP++T + + LQ+AK
Sbjct: 457 SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSAT--PPPQAPPPLAAPPLQLAK 514
Query: 1129 TLSEVDYAPAGPARSAL------LPGPLELQPPRGLPSDYGRPLSFPPPRIRESIQEDLA 1182
+ A A P AL PG P LP PL+ PPP+ + L
Sbjct: 515 PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMS---PLATPPPQAPPVLAAPLL 571
Query: 1183 EEAP 1186
+ P
Sbjct: 572 QVPP 575
Score = 53.1 bits (126), Expect = 2e-06
Identities = 89/363 (24%), Positives = 113/363 (31%), Gaps = 103/363 (28%)
Query: 896 AGAKSKAPSVSRGS---------QEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPP- 945
AGA + P R PR+G + A T + P SR PP +GR
Sbjct: 50 AGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSRNPASR-------PPASGRGER 102
Query: 946 APPRAAPREEPLTPRLKPEGAPEP-----------------EGVAAPPPKNSFNNPAYYV 988
APP P++ + G P G A PK S +
Sbjct: 103 APPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSA------L 156
Query: 989 LEGVPHQLLPPEP--PSPARAPVPSATKNKVAITVPAPQLGHHRHPRVG--EGSSSDEES 1044
G P P PSPA A A +V + PAP R P G + SS E
Sbjct: 157 SAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPS-ARPRPPTEGPRKSVSSASEH 215
Query: 1045 GGTLPPPDFPPPPLPDSAIFLPPSLD------PLPGPVVRGRGGAEARGPPPPKAHPRPP 1098
T P P P + P S PL P R G ARG P AHP P
Sbjct: 216 STTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPA---RSGPSARGTPRAPAHPSQP 272
Query: 1099 LPPG------------------------------PSPASTFLGE----VASGDDRSCSVL 1124
P G PSP++ + + + S
Sbjct: 273 KPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTC 332
Query: 1125 QMAKTLSEVDYAPAGPARSALLPGPLELQPPRG---------------LPSDYGRPLSFP 1169
Q+A L +P+ P LP P P + LPS PL+ P
Sbjct: 333 QLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATP 392
Query: 1170 PPR 1172
PP+
Sbjct: 393 PPQ 395
Score = 45.1 bits (105), Expect = 4e-04
Identities = 66/235 (28%), Positives = 78/235 (33%), Gaps = 76/235 (32%)
Query: 919 PAFTEASCPLSRLFEEPEKPPPTGR------PPAPPRA----APREEPLT--------PR 960
P AS P+S L P + PP PP+PP + APR P PR
Sbjct: 543 PFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPR 602
Query: 961 LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAIT 1020
L AP P PPP P PS + A + A +
Sbjct: 603 LTLALAPGP-----PPP--------------------PSRSPSSTLSGPDLAGHSSSATS 637
Query: 1021 VPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDF-------------PPPPLPDSAIFLPP 1067
P G+ P G +S PPPD P PPL F
Sbjct: 638 TPEELRGYDSGPEGGAAAS---------PPPDAELAACHPAAWSRGPAPPL----AFRGA 684
Query: 1068 SLDPLPGPVVRGRGGAEA-----RGPPPPKAHPRP-PLPPGPSPASTFLGEVASG 1116
PLP P G G A+ P A P P L PGPSP T G+ A+G
Sbjct: 685 PGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSP-GTSGGKAAAG 738
Score = 35.4 bits (80), Expect = 0.35
Identities = 56/224 (25%), Positives = 70/224 (31%), Gaps = 53/224 (23%)
Query: 902 APSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAP------REE 955
+P S Q PR T S P L P PPP R P+ + P
Sbjct: 576 SPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSA 635
Query: 956 PLTPR--LKPEGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPS-A 1012
TP + PE A+PPP +L P + +R P P A
Sbjct: 636 TSTPEELRGYDSGPEGGAAASPPP---------------DAELAACHPAAWSRGPAPPLA 680
Query: 1013 TKNKVAITVPAPQLGHHRHPRVGEGSSSD-----EESGGTLPPPDFPPPPLPDSAIFLPP 1067
+ +P P P G GS+ E G P+SA P
Sbjct: 681 FRGAPGAPLPWP-------PATGPGSADGLCTIYETEG-------------PESATPAPG 720
Query: 1068 SLDPLPGPVVRGRGGAEARGPPPPKAHPRP----PLPPGPSPAS 1107
+LDP P P G A G P+ LP G AS
Sbjct: 721 ALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQAS 764
Score = 32.0 bits (71), Expect = 3.8
Identities = 50/193 (25%), Positives = 63/193 (32%), Gaps = 31/193 (16%)
Query: 996 LLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPP 1055
LL P PP R P P T + + A +G R P GG P P
Sbjct: 24 LLTPRPPGSPRPP-PPVTPAALRVLGAAGAVG--RKPLAERAGG----IGGATIPESAPR 76
Query: 1056 PPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFLGEVAS 1115
SA S +P P GRG R PP P P PG + +T G +
Sbjct: 77 AGPTRSA--GTSSRNPASRPPASGRG---ERAPPAKNTSPGPVSSPGRASGTTRPGPLGQ 131
Query: 1116 GDDRSCSVLQMAKTLSEVDYAPAGPARSAL--------------LPGPLELQPPRGLPSD 1161
R + +A+ A P RSAL P P + R ++
Sbjct: 132 KGLRISAEETVAR-----GKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTE 186
Query: 1162 YGRPLSFPPPRIR 1174
G P P R R
Sbjct: 187 VGLPRPAPSARPR 199
>gi|18959210 WIRE protein [Homo sapiens]
Length = 440
Score = 70.5 bits (171), Expect = 1e-11
Identities = 91/337 (27%), Positives = 122/337 (36%), Gaps = 58/337 (17%)
Query: 810 LADIEYLQDQHLLLTVKSMDGYESYGECVVALKSMIGSTAQQFLTFLSHRGEETG--NIR 867
L + + D+ + K YG AL+ G Q + L G + G N+
Sbjct: 50 LKKVTNINDRSAPILEKPKGSSGGYGSGGAALQPK-GGLFQGGVLKLRPVGAKDGSENLA 108
Query: 868 GSMKVRVPTERLGTRERLYEWIS--IDKDEAGAKSKAPSVSRGSQEPRSGSRKPAFTEAS 925
G +++P+ R S D +++ P + R Q P T +S
Sbjct: 109 GKPALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPR-MQRPSLPDLSRPNTTSS 167
Query: 926 CPLSRLFEEPEKPPPTGRPPAPPRAAP----------REEPLTPRLKPEGAPEPEGVAAP 975
+ P PPP R APP P RE+PL P P EG AP
Sbjct: 168 TGMKHSSSAPPPPPPGRRANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAP 227
Query: 976 PPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPV-----PSATKNKVAITVPAPQLGHHR 1030
PP +P + G Q L P PP P R P PS+ N+ A +P HR
Sbjct: 228 PPVKPPPSPVN-IRTGPSGQSLAPPPP-PYRQPPGVPNGPSSPTNESAPELPQRHNSLHR 285
Query: 1031 HPRVGEGSSSDEESGGTLPPP----------DFPPPPLPDSAIFLPPS---LDPLPGPVV 1077
+ G PPP + PPPP D PPS P P PV+
Sbjct: 286 --------KTPGPVRGLAPPPPTSASPSLLSNRPPPPARD-----PPSRGAAPPPPPPVI 332
Query: 1078 RGRGGAEARGPPPP--------KAHPRPPLPPGPSPA 1106
R G +A PPPP + +PP PP +PA
Sbjct: 333 RN-GARDAPPPPPPYRMHGSEPPSRGKPPPPPSRTPA 368
Score = 44.3 bits (103), Expect = 7e-04
Identities = 58/258 (22%), Positives = 81/258 (31%), Gaps = 48/258 (18%)
Query: 940 PTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAP-------PPKNSFNNPAYYVLEGV 992
P + P+ AAPR +P+ + + P P + P G+
Sbjct: 111 PALQIPSSRAAAPRPPVSAASGRPQDDTDSSRASLPELPRMQRPSLPDLSRPNTTSSTGM 170
Query: 993 PHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHH-RHPRVGEGSSSDEESGGTLPPP 1051
H P PP P R A P P H + P G L P
Sbjct: 171 KHSSSAPPPPPPGRR----------ANAPPTPLPMHSSKAPAYNREKPLPPTPGQRLHPG 220
Query: 1052 DFPPPPLPDSAIFLPPSLDPLPGPV-VRGRGGAEARGPPPPKAHPRPPLPPGPSPASTFL 1110
PP PP + P P PV +R ++ PPPP P +P GPS +
Sbjct: 221 REGPPA--------PPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPGVPNGPSSPT--- 269
Query: 1111 GEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQ---------PPRGLPSD 1161
+ S ++ + + + GP R P P PP P
Sbjct: 270 ---------NESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPPPARDPPS 320
Query: 1162 YGRPLSFPPPRIRESIQE 1179
G PPP IR ++
Sbjct: 321 RGAAPPPPPPVIRNGARD 338
Score = 42.0 bits (97), Expect = 0.004
Identities = 52/186 (27%), Positives = 62/186 (33%), Gaps = 40/186 (21%)
Query: 912 PRSGSRKPAFTEAS----CPLSRLF---EEPEKPPPTGRPPAPP--RAAPREEPLTPRLK 962
P S+ PA+ P RL E P PPP PP+P R P + L P
Sbjct: 194 PMHSSKAPAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPP 253
Query: 963 PEGAPE--PEGVAAP-----PPKNSFNNPAYYVLEGVPHQLLPP------------EPPS 1003
P P P G ++P P +N + G L PP PP
Sbjct: 254 PYRQPPGVPNGPSSPTNESAPELPQRHNSLHRKTPGPVRGLAPPPPTSASPSLLSNRPPP 313
Query: 1004 PAR---------APVPSATKN--KVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPD 1052
PAR P P +N + A P P H P G S PP
Sbjct: 314 PARDPPSRGAAPPPPPPVIRNGARDAPPPPPPYRMHGSEPP-SRGKPPPPPSRTPAGPPP 372
Query: 1053 FPPPPL 1058
PPPPL
Sbjct: 373 PPPPPL 378
Score = 35.4 bits (80), Expect = 0.35
Identities = 45/156 (28%), Positives = 51/156 (32%), Gaps = 29/156 (18%)
Query: 904 SVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKP 963
S+ R + P G P T AS L +PPP R P AAP P R
Sbjct: 282 SLHRKTPGPVRGLAPPPPTSASPSLLS-----NRPPPPARDPPSRGAAPPPPPPVIRNGA 336
Query: 964 EGAPEPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPA 1023
AP P PPP Y + G PP P+R P P
Sbjct: 337 RDAPPP-----PPP---------YRMHGSEPPSRGKPPPPPSRTPAGPPPP-------PP 375
Query: 1024 PQL--GHHRHPRVGEGSSSDEESGGTL-PPPDFPPP 1056
P L GH D ES + P DFP P
Sbjct: 376 PPLRNGHRDSITTVRSFLDDFESKYSFHPVEDFPAP 411
Score = 32.3 bits (72), Expect = 2.9
Identities = 20/71 (28%), Positives = 29/71 (40%), Gaps = 2/71 (2%)
Query: 116 PVEGEREPDPPDDRDASDGEDEKPPLPP--RSGSTSISAPTGPSSPLPAPETPTAPAAES 173
P +P PP E PP PP + + ++ TGPS AP P
Sbjct: 201 PAYNREKPLPPTPGQRLHPGREGPPAPPPVKPPPSPVNIRTGPSGQSLAPPPPPYRQPPG 260
Query: 174 APNGLSTVSHD 184
PNG S+ +++
Sbjct: 261 VPNGPSSPTNE 271
>gi|7706501 WW domain binding protein 11 [Homo sapiens]
Length = 641
Score = 68.9 bits (167), Expect = 3e-11
Identities = 80/271 (29%), Positives = 103/271 (38%), Gaps = 53/271 (19%)
Query: 869 SMKVRVPTERLGTRERLYEWISIDKDEAGA---KSKAPSVSRGSQEPRSGSRKPAFTEA- 924
+M +R+ + + R E S D DE + +++ S + +E S A ++
Sbjct: 332 AMMLRMAGQEIPEEGREVEEFSEDDDEDDSDDSEAEKQSQKQHKEESHSDGTSTASSQQQ 391
Query: 925 ----SCPLSRLFEEPEK-PPPTGRPPAPPRAAPREEPLTPRLKPEGAPEPEGVAAPPPKN 979
S P S++ P PPP G PPAP PL P P G P APP
Sbjct: 392 APPQSVPPSQIQAPPMPGPPPLGPPPAP--------PLRPPGPPTGLPPGPPPGAPP--- 440
Query: 980 SFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSS 1039
P L G +LLPP PP P R P P P P P + G
Sbjct: 441 FLRPPGMPGLRGPLPRLLPPGPP-PGRPPGPP----------PGPP------PGLPPG-- 481
Query: 1040 SDEESGGTLPPPDFPPPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPL 1099
PPP PPP LP A PP + P P P + GP PP P PL
Sbjct: 482 ---------PPPRGPPPRLPPPA---PPGIPP-PRPGMMRPPLVPPLGPAPPGLFPPAPL 528
Query: 1100 P-PGPSPASTFLGEVASGDDRSCSVLQMAKT 1129
P PG A L + DD S + ++ T
Sbjct: 529 PNPGVLSAPPNLIQRPKADDTSAATIEKKAT 559
>gi|160707881 formin 2 [Homo sapiens]
Length = 1722
Score = 68.6 bits (166), Expect = 4e-11
Identities = 58/175 (33%), Positives = 63/175 (36%), Gaps = 22/175 (12%)
Query: 938 PPPTGRPPAPPRAAPREEPLTPRLKPEGAPEP-EGVAAPPPKNSFNNPAYYVLEGVPHQL 996
PPP PP P P PL P P P G+ PPP P L G
Sbjct: 1064 PPP---PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGVGIPPPPPLPGAG--- 1117
Query: 997 LPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFP-- 1054
+PP PP P P I P P PRVG G PPP P
Sbjct: 1118 IPPPPPLPGAGIPPPPPLPGAGIPPPPPL------PRVGIPPPPPLPGAGIPPPPPLPGA 1171
Query: 1055 ----PPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSP 1105
PPPLP I PP PLPG + G PPP P +PP P+P
Sbjct: 1172 GIPPPPPLPGVGIPPPP---PLPGVGIPPPPPLPGAGIPPPPPLPGMGIPPAPAP 1223
Score = 64.3 bits (155), Expect = 7e-10
Identities = 74/261 (28%), Positives = 84/261 (32%), Gaps = 38/261 (14%)
Query: 919 PAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAPEP-EGVAAPPP 977
P A PL PPP PP P P PL P P P G+ PPP
Sbjct: 957 PPLPGAGIPLPPPLPGAGIPPP---PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPP 1013
Query: 978 KNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEG 1037
P L G +PP PP P P I P P P G
Sbjct: 1014 LPGAGIPPPPPLPGAG---IPPPPPLPGAGIPPPPPLPGAGIPPPPPL------PGAGIP 1064
Query: 1038 SSSDEESGGTLPPPDFP------PPPLPDSAIFLPPSLDPLPGPVVRGRGGAEARGPPPP 1091
G PPP P PPPLP + I PP PLPG + G PPP
Sbjct: 1065 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPP---PLPGVGIPPPPPLPGAGIPPP 1121
Query: 1092 KAHPRPPLPPGPSPASTFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLE 1151
P +PP P + + L V P P A +P P
Sbjct: 1122 PPLPGAGIPPPPPLPG--------------AGIPPPPPLPRVGIPPPPPLPGAGIPPPPP 1167
Query: 1152 LQPPRGLPSDYGRP-LSFPPP 1171
L P G+P P + PPP
Sbjct: 1168 L-PGAGIPPPPPLPGVGIPPP 1187
Score = 56.6 bits (135), Expect = 1e-07
Identities = 54/175 (30%), Positives = 61/175 (34%), Gaps = 22/175 (12%)
Query: 938 PPPTGRPPAPPRAAPREEPLTPRLKPEGAPEP-EGVAAPPPKNSFNNPAYYVLEGVPHQL 996
PPP PP P P PL P P P G+ PPP P L G
Sbjct: 1108 PPP---PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAG--- 1161
Query: 997 LPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFP-- 1054
+PP PP P P V I P P P VG G PPP P
Sbjct: 1162 IPPPPPLPGAGIPPPPPLPGVGIPPPPPL------PGVGIPPPPPLPGAGIPPPPPLPGM 1215
Query: 1055 ------PPPLPDSAIFLPPS-LDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPG 1102
PPLP +PP L P+ GP + + G+ P PPLP G
Sbjct: 1216 GIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTLPTPQVCGFLPPPLPSG 1270
Score = 55.8 bits (133), Expect = 2e-07
Identities = 57/202 (28%), Positives = 70/202 (34%), Gaps = 32/202 (15%)
Query: 908 GSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLKPEGAP 967
GSQ P S S + + S P P PP P + P + P P
Sbjct: 826 GSQPPHSISTEFQTSHEHSVSSAFKNSCNIPSP---PPLPCTESSSSMPGLGMVPPPPPP 882
Query: 968 EPEGVAAPPPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLG 1027
P P + P L+G ++LPP PP A +P A +P P L
Sbjct: 883 LPGMTVPTLPSTAIPQPP--PLQGT--EMLPPPPPPLPGAGIPPPPPLPGAGILPLPPL- 937
Query: 1028 HHRHPRVGEGSSSDEESGGTLPPPDFP------PPPLPDSAIFLPPSLDPLPGPVVRGRG 1081
G PPP P PPPLP + I LPP PLPG +
Sbjct: 938 ---------------PGAGIPPPPPLPGAAIPPPPPLPGAGIPLPP---PLPGAGIPPPP 979
Query: 1082 GAEARGPPPPKAHPRPPLPPGP 1103
G PPP P +PP P
Sbjct: 980 PLPGAGIPPPPPLPGAGIPPPP 1001
Score = 48.9 bits (115), Expect = 3e-05
Identities = 67/245 (27%), Positives = 88/245 (35%), Gaps = 46/245 (18%)
Query: 942 GRPPAPPRAAPREEP---------LTPR---LKPEGAPEPEGVAAPPPKNSFNNPAYYVL 989
GRPP PP A + ++PR ++ + + ++ PPP S A
Sbjct: 765 GRPPCPPGAESGPQTKFCSEISLIVSPRRISVQLDSHQPTQSISQPPPPPSLLWSAGQGQ 824
Query: 990 EGV-PHQLLPPEPPSPARAPVPSATKNKVAITVPAPQLGHHRHPRVGEGSSSDEESGGTL 1048
G P + E + V SA KN + +P+P P SSS G +
Sbjct: 825 PGSQPPHSISTEFQTSHEHSVSSAFKN--SCNIPSPP------PLPCTESSSSMPGLGMV 876
Query: 1049 PPPDFPPPPLPDSAI-FLPPSLDPLPGPVVRGRGGAEARGPPPPKAHPRPPLPPGPSPAS 1107
PPP PPPLP + LP + P P P+ G E PPPP PP P P +
Sbjct: 877 PPP---PPPLPGMTVPTLPSTAIPQPPPLQ----GTEMLPPPPPPLPGAGIPPPPPLPGA 929
Query: 1108 TFLGEVASGDDRSCSVLQMAKTLSEVDYAPAGPARSALLPGPLELQPPRGLPSDYGRP-L 1166
L L P P A +P P L P G+P P
Sbjct: 930 GIL---------------PLPPLPGAGIPPPPPLPGAAIPPPPPL-PGAGIPLPPPLPGA 973
Query: 1167 SFPPP 1171
PPP
Sbjct: 974 GIPPP 978
Score = 36.2 bits (82), Expect = 0.20
Identities = 66/272 (24%), Positives = 94/272 (34%), Gaps = 18/272 (6%)
Query: 903 PSVSRGSQEPRSGSRKPAFTEASCPLSRLFEEPEKPPPTGRPPAPPRAAPREEPLTPRLK 962
PS G + P S + A + S L EP +P +PP+P E P P +
Sbjct: 256 PSGGAG-EAPGSPDTEQALSALSDLPESLAAEPREPQ---QPPSPGGLPVSEAPSLPAAQ 311
Query: 963 PEGAPEPEGVAAP-PPKNSFNNPAYYVLEGVPHQLLPPEPPSPARAPVPSATKNKVAITV 1021
P P A P P A + G E + AP S +
Sbjct: 312 PAAKDSPSSTAFPFPEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEW----- 366
Query: 1022 PAPQLGHHRHPRVGEGSSSDEESGGTLPPPDFPPPPLPDSAIFLP-PSLDPLPGPVVRGR 1080
AP++G R+GE + + P P P F P P + P +
Sbjct: 367 -APEVGEDAPQRLGEEPEEEAQGPDAPAAASLPGSPAPSQRCFKPYPLITPCYIKTTTRQ 425
Query: 1081 GGAEARGP-PPPKAHPRPPLPPGPS---PASTFLGEVASGDDRSCSVLQMAKTLS-EVDY 1135
+ P P PR P PS + T L VA+ + + +A LS D+
Sbjct: 426 LSSPNHSPSQSPNQSPRIKRRPEPSLSRGSRTALASVAAPAKKHRADGGLAAGLSRSADW 485
Query: 1136 APAGPARSALLPGPLELQPPRGLPSDYGRPLS 1167
AR+ + G L RG+ SD G +S
Sbjct: 486 TEELGARTPRVGGSAHLL-ERGVASDSGGGVS 516
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.134 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 59,540,654
Number of Sequences: 37866
Number of extensions: 3814877
Number of successful extensions: 43657
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 413
Number of HSP's successfully gapped in prelim test: 1616
Number of HSP's that attempted gapping in prelim test: 19953
Number of HSP's gapped (non-prelim): 15461
length of query: 1258
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1144
effective length of database: 13,930,794
effective search space: 15936828336
effective search space used: 15936828336
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.