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Search of human proteins with 115298668
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo
sapiens]
(357 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 735 0.0
gi|23199987 WD repeat domain 5B [Homo sapiens] 173 2e-43
gi|16554629 WD repeat domain 5 [Homo sapiens] 172 5e-43
gi|16554627 WD repeat domain 5 [Homo sapiens] 172 5e-43
gi|32189425 WD repeat domain 69 [Homo sapiens] 142 4e-34
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 135 4e-32
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 135 4e-32
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 128 9e-30
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 128 9e-30
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 128 9e-30
gi|26665869 WD repeat domain 51B [Homo sapiens] 125 6e-29
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 124 1e-28
gi|113865883 WD repeat domain 38 [Homo sapiens] 123 2e-28
gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens] 122 6e-28
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 119 4e-27
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 119 5e-27
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 115 5e-26
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 115 5e-26
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 115 6e-26
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 115 6e-26
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 115 6e-26
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 112 7e-25
gi|7706657 cell division cycle 40 homolog [Homo sapiens] 108 6e-24
gi|153791298 mitogen-activated protein kinase organizer 1 [Homo ... 108 1e-23
gi|14150114 mitogen-activated protein kinase organizer 1 [Homo s... 108 1e-23
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 107 2e-23
gi|21071067 TBP-associated factor 5 [Homo sapiens] 106 3e-23
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 105 8e-23
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 104 1e-22
gi|16445438 bromodomain and WD repeat domain containing 1 isofor... 103 2e-22
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 735 bits (1897), Expect = 0.0
Identities = 357/357 (100%), Positives = 357/357 (100%)
Query: 1 MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM 60
MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM
Sbjct: 1 MIEQQKRKGPELPLVPVKRQRHELLLGAGSGPGAGQQQATPGALLQAGPPRCSSLQAPIM 60
Query: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120
LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD
Sbjct: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120
Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Query: 181 IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG
Sbjct: 181 IRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
Query: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI 300
LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI
Sbjct: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKI 300
Query: 301 AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ
Sbjct: 301 AAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 173 bits (438), Expect = 2e-43
Identities = 102/288 (35%), Positives = 160/288 (55%), Gaps = 11/288 (3%)
Query: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
L GH V KF PNG LAS+ DRLI++W Y D TL GH+ + ++ +++D
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAY-DGKYEKTLYGHNLEISDVAWSSDS 95
Query: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
S L SAS DKT+ +WD +G+ +K LKGH+++V C L+ +GS D TVK+W++
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN-FNPPSNLIISGSFDETVKIWEV 154
Query: 182 RKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADS-VT 239
+ ++T ++ V AV FN + I+SG D ++WD + T+ + V+
Sbjct: 155 KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVS 214
Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
+ S G Y+L+ +DNT+++WD + RC+K + G H EK + ++S G K
Sbjct: 215 FVKFSPNGKYILTATLDNTLKLWDYS----RGRCLKTYTG--HKNEKYCIFANFSVTGGK 268
Query: 300 -IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISAS 346
I +GS D VY+W+ ++ I+ KL GH + A HP E +I SA+
Sbjct: 269 WIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAA 316
Score = 107 bits (267), Expect = 2e-23
Identities = 60/208 (28%), Positives = 105/208 (50%), Gaps = 9/208 (4%)
Query: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD 120
L GH V+CC F+P + + S FD + +W V G C TL HS V +H+N
Sbjct: 121 LKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKC--LKTLSAHSDPVSAVHFNCS 178
Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
GS++ S S D +WD+ +G+ +K L + S + + T + D T+KLWD
Sbjct: 179 GSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWD 238
Query: 181 IRKKAAIQTF---QNTYQVLAVTFNDTSDQ-IISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
+ ++T+ +N + F+ T + I+SG DN + +W+L+ ++ ++GH D
Sbjct: 239 YSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 298
Query: 237 SVTGLSLSSEGSYLLSNAMDN--TVRVW 262
V + + + S A++N T+++W
Sbjct: 299 VVISAACHPTENLIASAALENDKTIKLW 326
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 172 bits (435), Expect = 5e-43
Identities = 107/319 (33%), Positives = 170/319 (53%), Gaps = 16/319 (5%)
Query: 34 AGQQQATPGA-LLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILL 92
A + Q TP + Q+ P A L+GH V KF PNG LAS+ D+LI +
Sbjct: 12 AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKI 71
Query: 93 WNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTS 152
W Y D T+ GH + ++ +++D ++L SAS DKT+ +WD +G+ +K LKGH++
Sbjct: 72 WGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130
Query: 153 FVNSCYPARRGPQ--LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQII 209
+V C PQ L+ +GS D +V++WD++ ++T ++ V AV FN I+
Sbjct: 131 YVFCC---NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187
Query: 210 SGGIDNDIKVWDLRQNKLTYTMRGHADS-VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFA 268
S D ++WD + T+ + V+ + S G Y+L+ +DNT+++WD
Sbjct: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--- 244
Query: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSK-IAAGSADRFVYVWDTTSRRILYKLPGHA 327
K +C+K + G H EK + ++S G K I +GS D VY+W+ ++ I+ KL GH
Sbjct: 245 -KGKCLKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 301
Query: 328 GSINEVAFHPDEPIIISAS 346
+ A HP E II SA+
Sbjct: 302 DVVISTACHPTENIIASAA 320
Score = 109 bits (273), Expect = 3e-24
Identities = 61/208 (29%), Positives = 107/208 (51%), Gaps = 9/208 (4%)
Query: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD 120
L GH V+CC F+P + + S FD + +W+V G C TL HS V +H+N D
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRD 182
Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
GS++ S+S D +WD+ +G+ +K L + S + + + D T+KLWD
Sbjct: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Query: 181 IRKKAAIQTF---QNTYQVLAVTFNDTSDQ-IISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
K ++T+ +N + F+ T + I+SG DN + +W+L+ ++ ++GH D
Sbjct: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302
Query: 237 SVTGLSLSSEGSYLLSNAMDN--TVRVW 262
V + + + S A++N T+++W
Sbjct: 303 VVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 172 bits (435), Expect = 5e-43
Identities = 107/319 (33%), Positives = 170/319 (53%), Gaps = 16/319 (5%)
Query: 34 AGQQQATPGA-LLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILL 92
A + Q TP + Q+ P A L+GH V KF PNG LAS+ D+LI +
Sbjct: 12 AARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKI 71
Query: 93 WNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTS 152
W Y D T+ GH + ++ +++D ++L SAS DKT+ +WD +G+ +K LKGH++
Sbjct: 72 WGAY-DGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSN 130
Query: 153 FVNSCYPARRGPQ--LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQII 209
+V C PQ L+ +GS D +V++WD++ ++T ++ V AV FN I+
Sbjct: 131 YVFCC---NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV 187
Query: 210 SGGIDNDIKVWDLRQNKLTYTMRGHADS-VTGLSLSSEGSYLLSNAMDNTVRVWDVRPFA 268
S D ++WD + T+ + V+ + S G Y+L+ +DNT+++WD
Sbjct: 188 SSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS--- 244
Query: 269 PKERCVKIFQGNVHNFEKNLLRCSWSPDGSK-IAAGSADRFVYVWDTTSRRILYKLPGHA 327
K +C+K + G H EK + ++S G K I +GS D VY+W+ ++ I+ KL GH
Sbjct: 245 -KGKCLKTYTG--HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT 301
Query: 328 GSINEVAFHPDEPIIISAS 346
+ A HP E II SA+
Sbjct: 302 DVVISTACHPTENIIASAA 320
Score = 109 bits (273), Expect = 3e-24
Identities = 61/208 (29%), Positives = 107/208 (51%), Gaps = 9/208 (4%)
Query: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTD 120
L GH V+CC F+P + + S FD + +W+V G C TL HS V +H+N D
Sbjct: 125 LKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKC--LKTLPAHSDPVSAVHFNRD 182
Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
GS++ S+S D +WD+ +G+ +K L + S + + + D T+KLWD
Sbjct: 183 GSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWD 242
Query: 181 IRKKAAIQTF---QNTYQVLAVTFNDTSDQ-IISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
K ++T+ +N + F+ T + I+SG DN + +W+L+ ++ ++GH D
Sbjct: 243 YSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTD 302
Query: 237 SVTGLSLSSEGSYLLSNAMDN--TVRVW 262
V + + + S A++N T+++W
Sbjct: 303 VVISTACHPTENIIASAALENDKTIKLW 330
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 142 bits (359), Expect = 4e-34
Identities = 83/283 (29%), Positives = 145/283 (51%), Gaps = 12/283 (4%)
Query: 77 NGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD-GSMLFSASTDKTVAV 135
+GS + +DR LW+ + TL+GH V + +N G + + S DKT +
Sbjct: 103 SGSCFITGSYDRTCKLWDTASG-EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKL 161
Query: 136 WDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTY 194
W ETG+ +GHT+ + C LV TGS D T KLWDI+ + T + ++
Sbjct: 162 WSVETGKCYHTFRGHTAEI-VCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSA 220
Query: 195 QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNA 254
++++++FN + D+II+G D+ + VWD + + GH ++ S + + S +L+ +
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGS 280
Query: 255 MDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDT 314
MD T ++WD A +CV G+ + +L + G IA SAD ++
Sbjct: 281 MDKTCKLWD----ATNGKCVATLTGH----DDEILDSCFDYTGKLIATASADGTARIFSA 332
Query: 315 TSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
+R+ + KL GH G I++++F+P +++ SSDK + + Q
Sbjct: 333 ATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQ 375
Score = 139 bits (350), Expect = 4e-33
Identities = 83/290 (28%), Positives = 142/290 (48%), Gaps = 14/290 (4%)
Query: 62 LSGHEGEVYCCKFH-PNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNT 119
L GH VY F+ P G +A+ FD+ LW+V G C Y T +GH+ ++ L +N
Sbjct: 130 LEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKC--YHTFRGHTAEIVCLSFNP 187
Query: 120 DGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLW 179
+++ + S D T +WD + GE V L+GH++ + S G +++ TGS D TV +W
Sbjct: 188 QSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVW 246
Query: 180 DIRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSV 238
D + + ++ + +FN I++G +D K+WD K T+ GH D +
Sbjct: 247 DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI 306
Query: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGS 298
G + + + D T R++ A +C+ +G+ E + + S++P G+
Sbjct: 307 LDSCFDYTGKLIATASADGTARIFS----AATRKCIAKLEGH----EGEISKISFNPQGN 358
Query: 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
+ GS+D+ +WD + + L L GH I AF+ I+I+ S D
Sbjct: 359 HLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKD 408
Score = 127 bits (320), Expect = 1e-29
Identities = 76/248 (30%), Positives = 125/248 (50%), Gaps = 9/248 (3%)
Query: 102 YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR 161
+ LK H + + N GS + S D+T +WD+ +GE + L+GH + V +
Sbjct: 85 FKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNN 144
Query: 162 RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
+ TGS D T KLW + TF+ +T +++ ++FN S + +G +D K+W
Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204
Query: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280
D++ + YT+RGH+ + LS ++ G +++ + D+TV VWD A R V I G
Sbjct: 205 DIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD----ADTGRKVNILIG- 259
Query: 281 VHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP 340
H E + +W D S I GS D+ +WD T+ + + L GH I + F
Sbjct: 260 -HCAEISSASFNW--DCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK 316
Query: 341 IIISASSD 348
+I +AS+D
Sbjct: 317 LIATASAD 324
Score = 113 bits (283), Expect = 2e-25
Identities = 63/242 (26%), Positives = 109/242 (45%), Gaps = 45/242 (18%)
Query: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
GH E+ C F+P + +A+ D LW++ + Y TL+GHS ++ L +NT G
Sbjct: 175 GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY-TLRGHSAEIISLSFNTSGDR 233
Query: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183
+ + S D TV VWD++TG +V L GH + ++S L+ TGS D T KLWD
Sbjct: 234 IITGSFDHTVVVWDADTGRKVNILIGHCAEISSA-SFNWDCSLILTGSMDKTCKLWDATN 292
Query: 184 KAAIQT------------FQNTYQVLA-------------------------------VT 200
+ T F T +++A ++
Sbjct: 293 GKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Query: 201 FNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVR 260
FN + +++G D ++WD + + + GH D + + + +G+ +++ + DNT R
Sbjct: 353 FNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCR 412
Query: 261 VW 262
+W
Sbjct: 413 IW 414
Score = 75.9 bits (185), Expect = 5e-14
Identities = 39/121 (32%), Positives = 68/121 (56%), Gaps = 2/121 (1%)
Query: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYN 118
+ L+GH+ E+ F G +A+A D +++ A L+GH G + ++ +N
Sbjct: 296 VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSA-ATRKCIAKLEGHEGEISKISFN 354
Query: 119 TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKL 178
G+ L + S+DKT +WD++TG+ ++ L+GHT + SC +G +V TGS D T ++
Sbjct: 355 PQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKG-NIVITGSKDNTCRI 413
Query: 179 W 179
W
Sbjct: 414 W 414
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 135 bits (341), Expect = 4e-32
Identities = 95/318 (29%), Positives = 151/318 (47%), Gaps = 30/318 (9%)
Query: 32 PGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLIL 91
PG+G++ P L + H+GEV +F P LA+ G DR +
Sbjct: 302 PGSGKEVRVPATAL--------------CVFDAHDGEVNAVQFSPGSRLLATGGMDRRVK 347
Query: 92 LWNVYGD-CDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGH 150
LW V+G+ C+ +L G + + + +++ GS L +AS D +W + L GH
Sbjct: 348 LWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGH 407
Query: 151 TSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFND---TSDQ 207
+ V S ++V +GS D T+KLWD+R K I+T + ND T
Sbjct: 408 SGKVLSAKFLLDNARIV-SGSHDRTLKLWDLRSKVCIKTV-----FAGSSCNDIVCTEQC 461
Query: 208 IISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPF 267
++SG D I+ WD+R + M +T L L+ E + LLS + D+ ++V D+R
Sbjct: 462 VMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPERTELLSCSRDDLLKVIDLRTN 520
Query: 268 APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL-PGH 326
A K+ F + R +SPDGS +AAGSA+ +Y+W + ++ L H
Sbjct: 521 AIKQ----TFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQH 576
Query: 327 AGSINEVAFHPDEPIIIS 344
+ SIN VA+ P ++S
Sbjct: 577 SSSINAVAWSPSGSHVVS 594
Score = 61.2 bits (147), Expect = 1e-09
Identities = 43/195 (22%), Positives = 90/195 (46%), Gaps = 21/195 (10%)
Query: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-----VLAVTFNDTSDQIISGGIDNDI 217
G +L+ TG D VKLW++ + F+ + + ++ F+ +++ D
Sbjct: 333 GSRLLATGGMDRRVKLWEVFGEKC--EFKGSLSGSNAGITSIEFDSAGSYLLAASNDFAS 390
Query: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVK-I 276
++W + +L +T+ GH+ V + + ++S + D T+++WD+R + C+K +
Sbjct: 391 RIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLR----SKVCIKTV 446
Query: 277 FQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
F G+ N +C + +G D+ + WD S I+ ++ G I + +
Sbjct: 447 FAGSSCNDIVCTEQC--------VMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLN 497
Query: 337 PDEPIIISASSDKRL 351
P+ ++S S D L
Sbjct: 498 PERTELLSCSRDDLL 512
Score = 49.7 bits (117), Expect = 4e-06
Identities = 31/124 (25%), Positives = 54/124 (43%), Gaps = 6/124 (4%)
Query: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293
H V + S L + MD V++W+V E+C F+G++ + +
Sbjct: 321 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFG----EKCE--FKGSLSGSNAGITSIEF 374
Query: 294 SPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
GS + A S D +W R+ + L GH+G + F D I+S S D+ L +
Sbjct: 375 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 434
Query: 354 GEIQ 357
+++
Sbjct: 435 WDLR 438
Score = 28.5 bits (62), Expect = 9.7
Identities = 14/63 (22%), Positives = 28/63 (44%)
Query: 74 FHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTV 133
F P+GS +A+ + + +W+V K HS ++ + ++ GS + S
Sbjct: 542 FSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKA 601
Query: 134 AVW 136
+W
Sbjct: 602 VLW 604
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 135 bits (341), Expect = 4e-32
Identities = 95/318 (29%), Positives = 151/318 (47%), Gaps = 30/318 (9%)
Query: 32 PGAGQQQATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLIL 91
PG+G++ P L + H+GEV +F P LA+ G DR +
Sbjct: 283 PGSGKEVRVPATAL--------------CVFDAHDGEVNAVQFSPGSRLLATGGMDRRVK 328
Query: 92 LWNVYGD-CDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGH 150
LW V+G+ C+ +L G + + + +++ GS L +AS D +W + L GH
Sbjct: 329 LWEVFGEKCEFKGSLSGSNAGITSIEFDSAGSYLLAASNDFASRIWTVDDYRLRHTLTGH 388
Query: 151 TSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFND---TSDQ 207
+ V S ++V +GS D T+KLWD+R K I+T + ND T
Sbjct: 389 SGKVLSAKFLLDNARIV-SGSHDRTLKLWDLRSKVCIKTV-----FAGSSCNDIVCTEQC 442
Query: 208 IISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPF 267
++SG D I+ WD+R + M +T L L+ E + LLS + D+ ++V D+R
Sbjct: 443 VMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLNPERTELLSCSRDDLLKVIDLRTN 501
Query: 268 APKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKL-PGH 326
A K+ F + R +SPDGS +AAGSA+ +Y+W + ++ L H
Sbjct: 502 AIKQ----TFSAPGFKCGSDWTRVVFSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQH 557
Query: 327 AGSINEVAFHPDEPIIIS 344
+ SIN VA+ P ++S
Sbjct: 558 SSSINAVAWSPSGSHVVS 575
Score = 61.2 bits (147), Expect = 1e-09
Identities = 43/195 (22%), Positives = 90/195 (46%), Gaps = 21/195 (10%)
Query: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ-----VLAVTFNDTSDQIISGGIDNDI 217
G +L+ TG D VKLW++ + F+ + + ++ F+ +++ D
Sbjct: 314 GSRLLATGGMDRRVKLWEVFGEKC--EFKGSLSGSNAGITSIEFDSAGSYLLAASNDFAS 371
Query: 218 KVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVK-I 276
++W + +L +T+ GH+ V + + ++S + D T+++WD+R + C+K +
Sbjct: 372 RIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLWDLR----SKVCIKTV 427
Query: 277 FQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
F G+ N +C + +G D+ + WD S I+ ++ G I + +
Sbjct: 428 FAGSSCNDIVCTEQC--------VMSGHFDKKIRFWDIRSESIVREME-LLGKITALDLN 478
Query: 337 PDEPIIISASSDKRL 351
P+ ++S S D L
Sbjct: 479 PERTELLSCSRDDLL 493
Score = 49.7 bits (117), Expect = 4e-06
Identities = 31/124 (25%), Positives = 54/124 (43%), Gaps = 6/124 (4%)
Query: 234 HADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293
H V + S L + MD V++W+V E+C F+G++ + +
Sbjct: 302 HDGEVNAVQFSPGSRLLATGGMDRRVKLWEVFG----EKCE--FKGSLSGSNAGITSIEF 355
Query: 294 SPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
GS + A S D +W R+ + L GH+G + F D I+S S D+ L +
Sbjct: 356 DSAGSYLLAASNDFASRIWTVDDYRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKL 415
Query: 354 GEIQ 357
+++
Sbjct: 416 WDLR 419
Score = 28.5 bits (62), Expect = 9.7
Identities = 14/63 (22%), Positives = 28/63 (44%)
Query: 74 FHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTV 133
F P+GS +A+ + + +W+V K HS ++ + ++ GS + S
Sbjct: 523 FSPDGSYVAAGSAEGSLYIWSVLTGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDKGCKA 582
Query: 134 AVW 136
+W
Sbjct: 583 VLW 585
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 128 bits (321), Expect = 9e-30
Identities = 67/222 (30%), Positives = 120/222 (54%), Gaps = 11/222 (4%)
Query: 138 SETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQV 196
++T +++ + H S V+S + +L+ TG DD V LW I K I + +T V
Sbjct: 7 TKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPV 66
Query: 197 LAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD 256
+V N + I++G I+VWDL K+ T+ GH ++ L G ++ S + D
Sbjct: 67 ESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQD 126
Query: 257 NTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC-SWSPDGSKIAAGSADRFVYVWDTT 315
+++WD+R ++ CV ++G+ +RC +SPDG +A+ + D V +WD T
Sbjct: 127 TNIKLWDIR----RKGCVFRYRGH-----SQAVRCLRFSPDGKWLASAADDHTVKLWDLT 177
Query: 316 SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
+ +++ + PGH G +N V FHP+E ++ S SSD+ + +++
Sbjct: 178 AGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE 219
Score = 105 bits (261), Expect = 8e-23
Identities = 65/234 (27%), Positives = 116/234 (49%), Gaps = 11/234 (4%)
Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
G +L + D V +W + L GHTS V S +L+ GS G++++WD
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVR-LNTPEELIVAGSQSGSIRVWD 91
Query: 181 IRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
+ ++T + + ++ F+ + + SG D +IK+WD+R+ + RGH+ +V
Sbjct: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
L S +G +L S A D+TV++WD+ + + F G H N++ + P+
Sbjct: 152 CLRFSPDGKWLASAADDHTVKLWDLTA----GKMMSEFPG--HTGPVNVVE--FHPNEYL 203
Query: 300 IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK-RLY 352
+A+GS+DR + WD +++ + G G + V F+PD + S D R+Y
Sbjct: 204 LASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVY 257
Score = 97.4 bits (241), Expect = 2e-20
Identities = 66/239 (27%), Positives = 111/239 (46%), Gaps = 12/239 (5%)
Query: 77 NGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVW 136
+G LA+ G D + LW++ + +L GH+ V + NT ++ + S ++ VW
Sbjct: 32 SGRLLATGGDDCRVNLWSI-NKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90
Query: 137 DSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ- 195
D E + ++ L GH + + S G + V +GS D +KLWDIR+K + ++ Q
Sbjct: 91 DLEAAKILRTLMGHKANICSLDFHPYG-EFVASGSQDTNIKLWDIRRKGCVFRYRGHSQA 149
Query: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
V + F+ + S D+ +K+WDL K+ GH V + L S +
Sbjct: 150 VRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSS 209
Query: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRF-VYVWD 313
D T+R WD+ F C++ G V + ++PDG + +G D VY W+
Sbjct: 210 DRTIRFWDLEKFQVVS-CIEGEPGPVRS-------VLFNPDGCCLYSGCQDSLRVYGWE 260
Score = 80.9 bits (198), Expect = 2e-15
Identities = 58/175 (33%), Positives = 83/175 (47%), Gaps = 9/175 (5%)
Query: 46 QAGPPRCSSLQAPIML--LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY--GDCDN 101
Q+G R L+A +L L GH+ + FHP G +AS D I LW++ G
Sbjct: 83 QSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR 142
Query: 102 YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR 161
Y +GHS AV L ++ DG L SA+ D TV +WD G+ + GHT VN
Sbjct: 143 Y---RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVN-VVEFH 198
Query: 162 RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDN 215
L+ +GS D T++ WD+ K + + V +V FN + SG D+
Sbjct: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 128 bits (321), Expect = 9e-30
Identities = 88/289 (30%), Positives = 132/289 (45%), Gaps = 11/289 (3%)
Query: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
GH V C F N LAS D +++W++ Y GH AV ++++ G +
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHL 75
Query: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI-R 182
L S S DKTV +W + HT+ V S + G V T SDD TVK+W R
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV-TASDDKTVKVWATHR 134
Query: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
+K Q+ V F+ I+S D +K+WD + ++ H VT +
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
G+ + + MDNTV+VWDVR R ++ +Q +H+ N L S+ P G+ +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRT----HRLLQHYQ--LHSAAVNGL--SFHPSGNYLIT 246
Query: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
S+D + + D R+LY L GH G VAF S SD+++
Sbjct: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
Score = 124 bits (312), Expect = 1e-28
Identities = 76/253 (30%), Positives = 131/253 (51%), Gaps = 15/253 (5%)
Query: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLW--NVYGDCDNYATLKGHSGAVMELHYNTD 120
+GH+ V C F P+G LAS D+ + +W NV G+ + H+ V +H+ +D
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES---TVFRAHTATVRSVHFCSD 114
Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
G +AS DKTV VW + + + L H ++V C +L+ + SDD TVKLWD
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR-CAKFSPDGRLIVSASDDKTVKLWD 173
Query: 181 IRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
+ + ++ ++ V V F+ + I + G+DN +KVWD+R ++L + H+ +V
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
GLS G+YL++ + D+T+++ D+ + R + +H + ++S G
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLM----EGRLLY----TLHGHQGPATTVAFSRTGEY 285
Query: 300 IAAGSADRFVYVW 312
A+G +D V VW
Sbjct: 286 FASGGSDEQVMVW 298
Score = 108 bits (269), Expect = 1e-23
Identities = 71/250 (28%), Positives = 116/250 (46%), Gaps = 16/250 (6%)
Query: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165
KGH AV + ++ + L S S D + VW + R R GH V +C
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV-TCVNFSPSGH 74
Query: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
L+ +GS D TV++W K F+ +T V +V F ++ D +KVW +
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNF 284
K +++ H + V S +G ++S + D TV++WD K + VH++
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD-----------KSSRECVHSY 183
Query: 285 EKN---LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
++ + + P G+ IAA D V VWD + R+L H+ ++N ++FHP
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243
Query: 342 IISASSDKRL 351
+I+ASSD L
Sbjct: 244 LITASSDSTL 253
Score = 82.4 bits (202), Expect = 6e-16
Identities = 54/196 (27%), Positives = 89/196 (45%), Gaps = 34/196 (17%)
Query: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
V V F+ + Q+ SG +D+ + VW ++ Y GH D+VT ++ S G L S +
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 256 DNTVRVW-------------------------DVRPF--APKERCVKIFQGNVHNF---- 284
D TVR+W D + F A ++ VK++ + F
Sbjct: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
Query: 285 --EKNLLRCS-WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
N +RC+ +SPDG I + S D+ V +WD +SR ++ H G + V FHP
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
Query: 342 IISASSDKRLYMGEIQ 357
I +A D + + +++
Sbjct: 202 IAAAGMDNTVKVWDVR 217
Score = 75.1 bits (183), Expect = 9e-14
Identities = 49/166 (29%), Positives = 77/166 (46%), Gaps = 15/166 (9%)
Query: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN------VYGDCDNYATLKGHSGAVMEL 115
LS H V C KF P+G + SA D+ + LW+ V+ C+ H G V +
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-------HGGFVTYV 193
Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
++ G+ + +A D TV VWD T ++ + H++ VN G L+ T S D T
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDST 252
Query: 176 VKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
+K+ D+ + + T + V F+ T + SGG D + VW
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 37.7 bits (86), Expect = 0.016
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
H V FHP+G+ L +A D + + ++ Y TL GH G + ++ G
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY-TLHGHQGPATTVAFSRTGEYF 286
Query: 125 FSASTDKTVAVWDS 138
S +D+ V VW S
Sbjct: 287 ASGGSDEQVMVWKS 300
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 128 bits (321), Expect = 9e-30
Identities = 88/289 (30%), Positives = 132/289 (45%), Gaps = 11/289 (3%)
Query: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
GH V C F N LAS D +++W++ Y GH AV ++++ G +
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHL 75
Query: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI-R 182
L S S DKTV +W + HT+ V S + G V T SDD TVK+W R
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV-TASDDKTVKVWATHR 134
Query: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
+K Q+ V F+ I+S D +K+WD + ++ H VT +
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194
Query: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
G+ + + MDNTV+VWDVR R ++ +Q +H+ N L S+ P G+ +
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRT----HRLLQHYQ--LHSAAVNGL--SFHPSGNYLIT 246
Query: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
S+D + + D R+LY L GH G VAF S SD+++
Sbjct: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQV 295
Score = 124 bits (312), Expect = 1e-28
Identities = 76/253 (30%), Positives = 131/253 (51%), Gaps = 15/253 (5%)
Query: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLW--NVYGDCDNYATLKGHSGAVMELHYNTD 120
+GH+ V C F P+G LAS D+ + +W NV G+ + H+ V +H+ +D
Sbjct: 58 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES---TVFRAHTATVRSVHFCSD 114
Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
G +AS DKTV VW + + + L H ++V C +L+ + SDD TVKLWD
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR-CAKFSPDGRLIVSASDDKTVKLWD 173
Query: 181 IRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
+ + ++ ++ V V F+ + I + G+DN +KVWD+R ++L + H+ +V
Sbjct: 174 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 233
Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
GLS G+YL++ + D+T+++ D+ + R + +H + ++S G
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLM----EGRLLY----TLHGHQGPATTVAFSRTGEY 285
Query: 300 IAAGSADRFVYVW 312
A+G +D V VW
Sbjct: 286 FASGGSDEQVMVW 298
Score = 108 bits (269), Expect = 1e-23
Identities = 71/250 (28%), Positives = 116/250 (46%), Gaps = 16/250 (6%)
Query: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165
KGH AV + ++ + L S S D + VW + R R GH V +C
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAV-TCVNFSPSGH 74
Query: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
L+ +GS D TV++W K F+ +T V +V F ++ D +KVW +
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134
Query: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNF 284
K +++ H + V S +G ++S + D TV++WD K + VH++
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD-----------KSSRECVHSY 183
Query: 285 EKN---LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
++ + + P G+ IAA D V VWD + R+L H+ ++N ++FHP
Sbjct: 184 CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY 243
Query: 342 IISASSDKRL 351
+I+ASSD L
Sbjct: 244 LITASSDSTL 253
Score = 82.4 bits (202), Expect = 6e-16
Identities = 54/196 (27%), Positives = 89/196 (45%), Gaps = 34/196 (17%)
Query: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
V V F+ + Q+ SG +D+ + VW ++ Y GH D+VT ++ S G L S +
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 256 DNTVRVW-------------------------DVRPF--APKERCVKIFQGNVHNF---- 284
D TVR+W D + F A ++ VK++ + F
Sbjct: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
Query: 285 --EKNLLRCS-WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPI 341
N +RC+ +SPDG I + S D+ V +WD +SR ++ H G + V FHP
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTC 201
Query: 342 IISASSDKRLYMGEIQ 357
I +A D + + +++
Sbjct: 202 IAAAGMDNTVKVWDVR 217
Score = 75.1 bits (183), Expect = 9e-14
Identities = 49/166 (29%), Positives = 77/166 (46%), Gaps = 15/166 (9%)
Query: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN------VYGDCDNYATLKGHSGAVMEL 115
LS H V C KF P+G + SA D+ + LW+ V+ C+ H G V +
Sbjct: 141 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-------HGGFVTYV 193
Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
++ G+ + +A D TV VWD T ++ + H++ VN G L+ T S D T
Sbjct: 194 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDST 252
Query: 176 VKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
+K+ D+ + + T + V F+ T + SGG D + VW
Sbjct: 253 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
Score = 37.7 bits (86), Expect = 0.016
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
H V FHP+G+ L +A D + + ++ Y TL GH G + ++ G
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY-TLHGHQGPATTVAFSRTGEYF 286
Query: 125 FSASTDKTVAVWDS 138
S +D+ V VW S
Sbjct: 287 ASGGSDEQVMVWKS 300
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 125 bits (314), Expect = 6e-29
Identities = 80/304 (26%), Positives = 144/304 (47%), Gaps = 13/304 (4%)
Query: 53 SSLQAPIM--LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSG 110
S+ + P++ GH+ + PNG LA+A +D ++LWN Y + GH
Sbjct: 3 SATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYV-GHKD 61
Query: 111 AVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTG 170
V + ++ G++L SAS D+TV +W + + K HT+ V S + G Q + T
Sbjct: 62 VVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADG-QFLATA 120
Query: 171 SDDGTVKLWDI-RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229
S+D ++K+W + R++ +++T+ V F+ I+S D IK+WD +
Sbjct: 121 SEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVN 180
Query: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289
+ + G+ + S D TV+VWDVR + ++ +Q VH+ N +
Sbjct: 181 NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR----VNKLLQHYQ--VHSGGVNCI 234
Query: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349
S+ P G+ + S+D + + D R++Y L GH G + V+F + S +D
Sbjct: 235 --SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADT 292
Query: 350 RLYM 353
++ +
Sbjct: 293 QVLL 296
Score = 124 bits (312), Expect = 1e-28
Identities = 86/308 (27%), Positives = 143/308 (46%), Gaps = 24/308 (7%)
Query: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
GH+ V +F P+G+ LASA DR + LW + ++ K H+ V + ++ DG
Sbjct: 58 GHKDVVTSVQFSPHGNLLASASRDRTVRLW-IPDKRGKFSEFKAHTAPVRSVDFSADGQF 116
Query: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK 183
L +AS DK++ VW + L HT +V C +L+ + S+D T+K+WD
Sbjct: 117 LATASEDKSIKVWSMYRQRFLYSLYRHTHWVR-CAKFSPDGRLIVSCSEDKTIKIWDTTN 175
Query: 184 KAAIQTFQNTYQVLA-VTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
K + F ++ V FN + I S G D +KVWD+R NKL + H+ V +S
Sbjct: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235
Query: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
G+YL++ + D T+++ D+ + R + QG+ + S+S G A+
Sbjct: 236 FHPSGNYLITASSDGTLKILDLL----EGRLIYTLQGHTGP----VFTVSFSKGGELFAS 287
Query: 303 GSADRFVYVWDT-------------TSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349
G AD V +W T +R+ + P H I HP E + + +
Sbjct: 288 GGADTQVLLWRTNFDELHCKGLTKRNLKRLHFDSPPHLLDIYPRTPHPHEEKVETVEINP 347
Query: 350 RLYMGEIQ 357
+L + ++Q
Sbjct: 348 KLEVIDLQ 355
Score = 76.3 bits (186), Expect = 4e-14
Identities = 52/212 (24%), Positives = 101/212 (47%), Gaps = 12/212 (5%)
Query: 148 KGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVL-AVTFNDTSD 206
KGH + + S + G QL T S D + LW+ + A + V+ +V F+ +
Sbjct: 15 KGHKAAITSLDLSPNGKQLA-TASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73
Query: 207 QIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP 266
+ S D +++W + + H V + S++G +L + + D +++VW +
Sbjct: 74 LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMY- 132
Query: 267 FAPKERCVKIFQGNVHNFEKNLLRCS-WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG 325
++R + + H +RC+ +SPDG I + S D+ + +WDTT+++ +
Sbjct: 133 ---RQRFLYSLYRHTH-----WVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSD 184
Query: 326 HAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
G N V F+P I SA SD+ + + +++
Sbjct: 185 SVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
Score = 33.9 bits (76), Expect = 0.23
Identities = 16/40 (40%), Positives = 18/40 (45%)
Query: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD 98
I L GH G V+ F G AS G D +LLW D
Sbjct: 263 IYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFD 302
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 124 bits (312), Expect = 1e-28
Identities = 76/253 (30%), Positives = 131/253 (51%), Gaps = 15/253 (5%)
Query: 63 SGHEGEVYCCKFHPNGSTLASAGFDRLILLW--NVYGDCDNYATLKGHSGAVMELHYNTD 120
+GH+ V C F P+G LAS D+ + +W NV G+ + H+ V +H+ +D
Sbjct: 20 TGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES---TVFRAHTATVRSVHFCSD 76
Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
G +AS DKTV VW + + + L H ++V C +L+ + SDD TVKLWD
Sbjct: 77 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVR-CAKFSPDGRLIVSASDDKTVKLWD 135
Query: 181 IRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
+ + ++ ++ V V F+ + I + G+DN +KVWD+R ++L + H+ +V
Sbjct: 136 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN 195
Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
GLS G+YL++ + D+T+++ D+ + R + +H + ++S G
Sbjct: 196 GLSFHPSGNYLITASSDSTLKILDLM----EGRLLY----TLHGHQGPATTVAFSRTGEY 247
Query: 300 IAAGSADRFVYVW 312
A+G +D V VW
Sbjct: 248 FASGGSDEQVMVW 260
Score = 113 bits (283), Expect = 2e-25
Identities = 79/266 (29%), Positives = 123/266 (46%), Gaps = 11/266 (4%)
Query: 87 DRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKR 146
D +++W++ Y GH AV ++++ G +L S S DKTV +W
Sbjct: 2 DSCLMVWHMKPQSRAYR-FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 147 LKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI-RKKAAIQTFQNTYQVLAVTFNDTS 205
+ HT+ V S + G V T SDD TVK+W R+K Q+ V F+
Sbjct: 61 FRAHTATVRSVHFCSDGQSFV-TASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDG 119
Query: 206 DQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
I+S D +K+WD + ++ H VT + G+ + + MDNTV+VWDVR
Sbjct: 120 RLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
Query: 266 PFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG 325
R ++ +Q +H+ N L S+ P G+ + S+D + + D R+LY L G
Sbjct: 180 T----HRLLQHYQ--LHSAAVNGL--SFHPSGNYLITASSDSTLKILDLMEGRLLYTLHG 231
Query: 326 HAGSINEVAFHPDEPIIISASSDKRL 351
H G VAF S SD+++
Sbjct: 232 HQGPATTVAFSRTGEYFASGGSDEQV 257
Score = 75.1 bits (183), Expect = 9e-14
Identities = 49/166 (29%), Positives = 77/166 (46%), Gaps = 15/166 (9%)
Query: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN------VYGDCDNYATLKGHSGAVMEL 115
LS H V C KF P+G + SA D+ + LW+ V+ C+ H G V +
Sbjct: 103 LSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE-------HGGFVTYV 155
Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
++ G+ + +A D TV VWD T ++ + H++ VN G L+ T S D T
Sbjct: 156 DFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI-TASSDST 214
Query: 176 VKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
+K+ D+ + + T + V F+ T + SGG D + VW
Sbjct: 215 LKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 260
Score = 72.4 bits (176), Expect = 6e-13
Identities = 48/179 (26%), Positives = 80/179 (44%), Gaps = 34/179 (18%)
Query: 213 IDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVW---------- 262
+D+ + VW ++ Y GH D+VT ++ S G L S + D TVR+W
Sbjct: 1 MDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 263 ---------------DVRPF--APKERCVKIFQGNVHNF------EKNLLRCS-WSPDGS 298
D + F A ++ VK++ + F N +RC+ +SPDG
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
I + S D+ V +WD +SR ++ H G + V FHP I +A D + + +++
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179
Score = 37.7 bits (86), Expect = 0.016
Identities = 22/74 (29%), Positives = 34/74 (45%), Gaps = 1/74 (1%)
Query: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
H V FHP+G+ L +A D + + ++ Y TL GH G + ++ G
Sbjct: 190 HSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLY-TLHGHQGPATTVAFSRTGEYF 248
Query: 125 FSASTDKTVAVWDS 138
S +D+ V VW S
Sbjct: 249 ASGGSDEQVMVWKS 262
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 123 bits (309), Expect = 2e-28
Identities = 72/239 (30%), Positives = 122/239 (51%), Gaps = 8/239 (3%)
Query: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLV 167
H G V ++ DG ML + S D V W++ +G+ + RL GHT V C + G L
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDG-HLF 78
Query: 168 CTGSDDGTVKLWDIRKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNK 226
+ S D TV+LWD+ + ++ + + V V+F+ S Q+ SGG D + +WD++ +
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 227 LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEK 286
+ + GH DS+ S + L + + D+TV +WD+R P + +
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTP-----AVSHQALEGHSA 193
Query: 287 NLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
N+ +S G +A+GS D+ +++W T+ +L +L GH + +AF PDE + SA
Sbjct: 194 NISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASA 251
Score = 110 bits (274), Expect = 3e-24
Identities = 72/251 (28%), Positives = 117/251 (46%), Gaps = 17/251 (6%)
Query: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
L GH G V C+F P+G ASA D + LW+V LKGH +V + ++ D
Sbjct: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDV-ARAKCLRVLKGHQRSVETVSFSPDS 117
Query: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC--TGSDDGTVKLW 179
L S DK V +WD ++G+ ++ L GH + S + P + C TGS D TV +W
Sbjct: 118 RQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS---SDFSPTVNCLATGSWDSTVHIW 174
Query: 180 DIR---KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
D+R + Q + ++ S + SG D I +W + L ++GH
Sbjct: 175 DLRMVTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVT 234
Query: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296
V ++ S + +L S V+VWD +C++ +G + C+++PD
Sbjct: 235 WVKSIAFSPDELWLASAGYSRMVKVWDCN----TGKCLETLKGVLDVAH----TCAFTPD 286
Query: 297 GSKIAAGSADR 307
G + +G+AD+
Sbjct: 287 GKILVSGAADQ 297
Score = 101 bits (251), Expect = 1e-21
Identities = 80/290 (27%), Positives = 136/290 (46%), Gaps = 17/290 (5%)
Query: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
H GEV F P+G L + D + W L GH+G V ++ DG +
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSG-QLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 125 FSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKK 184
SAS D TV +WD + ++ LKGH V + + QL +G D V LWD++
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQL-ASGGWDKRVMLWDVQSG 137
Query: 185 AAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYT---MRGHADSVTG 240
++ + + + F+ T + + +G D+ + +WDLR + + GH+ +++
Sbjct: 138 QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISC 197
Query: 241 LSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKI-FQGNVHNFEKNLLRCSWSPDGSK 299
L S+ G L S + D T+ +W P + I +G+V + K++ ++SPD
Sbjct: 198 LCYSASG-LLASGSWDKTIHIW-----KPTTSSLLIQLKGHV-TWVKSI---AFSPDELW 247
Query: 300 IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK 349
+A+ R V VWD + + L L G + AF PD I++S ++D+
Sbjct: 248 LASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297
Score = 79.3 bits (194), Expect = 5e-15
Identities = 45/167 (26%), Positives = 84/167 (50%), Gaps = 8/167 (4%)
Query: 191 QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYL 250
Q+ +V + F+ +++G D + W+ R +L + + GH V S +G
Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 251 LSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVY 310
S + D TVR+WDV + +C+++ +G+ + E S+SPD ++A+G D+ V
Sbjct: 79 ASASCDCTVRLWDVA----RAKCLRVLKGHQRSVET----VSFSPDSRQLASGGWDKRVM 130
Query: 311 VWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
+WD S ++L L GH SI F P + + S D +++ +++
Sbjct: 131 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR 177
Score = 53.1 bits (126), Expect = 4e-07
Identities = 31/77 (40%), Positives = 41/77 (53%), Gaps = 4/77 (5%)
Query: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
R VK F H E N ++SPDG + GS D VY W+T S ++L++L GH G +
Sbjct: 12 RRVKFF--GQHGGEVN--SSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVK 67
Query: 332 EVAFHPDEPIIISASSD 348
F PD + SAS D
Sbjct: 68 FCRFSPDGHLFASASCD 84
>gi|55743108 ATG16 autophagy related 16-like 2 [Homo sapiens]
Length = 619
Score = 122 bits (305), Expect = 6e-28
Identities = 92/309 (29%), Positives = 146/309 (47%), Gaps = 13/309 (4%)
Query: 50 PRCSSLQAPIM---LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-CDNYATL 105
P C + + P +L H EV +F PN S LA+ G DRLI LWNV G + TL
Sbjct: 317 PVCVAARLPTRAQDVLDAHLSEVNAVRFGPNSSLLATGGADRLIHLWNVVGSRLEANQTL 376
Query: 106 KGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ 165
+G G++ + ++ G + +A+ ++ +W + + L GH V + Q
Sbjct: 377 EGAGGSITSVDFDPSGYQVLAATYNQAAQLWKVGEAQSKETLSGHKDKVTAAKFKLTRHQ 436
Query: 166 LVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN 225
V TGS D TVK WD+ + +T V D IISG D I+ WD R
Sbjct: 437 AV-TGSRDRTVKEWDLGRAYCSRTINVLSYCNDVVCGD--HIIISGHNDQKIRFWDSRGP 493
Query: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
T + VT LSLS + +LLS + DNT++V D+R ++F+ +
Sbjct: 494 HCTQVIPVQG-RVTSLSLSHDQLHLLSCSRDNTLKVIDLR----VSNIRQVFRADGFKCG 548
Query: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG-HAGSINEVAFHPDEPIIIS 344
+ + +SPD S AGS D +Y+WD + ++ +L G H ++N VA+ ++S
Sbjct: 549 SDWTKAVFSPDRSYALAGSCDGALYIWDVDTGKLESRLQGPHCAAVNAVAWCYSGSHMVS 608
Query: 345 ASSDKRLYM 353
+++ +
Sbjct: 609 VDQGRKVVL 617
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 119 bits (298), Expect = 4e-27
Identities = 86/315 (27%), Positives = 145/315 (46%), Gaps = 31/315 (9%)
Query: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
LSGH V FHP S + SA D I +W+ Y D TLKGH+ +V ++ ++ G
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD-YETGDFERTLKGHTDSVQDISFDHSG 162
Query: 122 SMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI 181
+L S S D T+ +WD + E ++ + GH V+S G +V + S D T+K+W++
Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIV-SASRDKTIKMWEV 221
Query: 182 RKKAAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTG 240
+ ++TF + V V N I S D ++VW + + +R H V
Sbjct: 222 QTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVEC 281
Query: 241 LSLSSEGSY--------------------LLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280
+S + E SY LLS + D T+++WDV C+ G+
Sbjct: 282 ISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDV----STGMCLMTLVGH 337
Query: 281 VHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP 340
N+ + +L + G I + + D+ + VWD ++R + L H + + FH P
Sbjct: 338 -DNWVRGVL---FHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAP 393
Query: 341 IIISASSDKRLYMGE 355
+++ S D+ + + E
Sbjct: 394 YVVTGSVDQTVKVWE 408
Score = 96.7 bits (239), Expect = 3e-20
Identities = 68/229 (29%), Positives = 102/229 (44%), Gaps = 25/229 (10%)
Query: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHY 117
I + GH+ V PNG + SA D+ I +W V G C T GH V +
Sbjct: 185 IRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYC--VKTFTGHREWVRMVRP 242
Query: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVN-------SCYPA---------- 160
N DG+++ S S D+TV VW T E L+ H V S Y +
Sbjct: 243 NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETK 302
Query: 161 ---RRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDND 216
+ GP L+ +GS D T+K+WD+ + T + V V F+ I+S D
Sbjct: 303 KSGKPGPFLL-SGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361
Query: 217 IKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR 265
++VWD + + T+ H VT L Y+++ ++D TV+VW+ R
Sbjct: 362 LRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 63.9 bits (154), Expect = 2e-10
Identities = 49/179 (27%), Positives = 80/179 (44%), Gaps = 12/179 (6%)
Query: 182 RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGI---DNDIKVWDLRQNKLTYTMRGHADSV 238
+K ++ Q L N+ ++ SGG D K W R + Y + GH V
Sbjct: 53 KKWTSVIRLQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPE-KYALSGHRSPV 111
Query: 239 TGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGS 298
T + S ++S + D T++VWD ER +K +V + S+ G
Sbjct: 112 TRVIFHPVFSVMVSASEDATIKVWDYET-GDFERTLKGHTDSVQDI-------SFDHSGK 163
Query: 299 KIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
+A+ SAD + +WD + + GH +++ VA P+ I+SAS DK + M E+Q
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQ 222
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 119 bits (297), Expect = 5e-27
Identities = 78/305 (25%), Positives = 144/305 (47%), Gaps = 10/305 (3%)
Query: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
P +LSGHE V C F + + L S +D + LW+ V+E
Sbjct: 94 PFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSI 153
Query: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177
D S + +AS DKTV WD ETG+ + +++ + +F+ SC + G +V D +
Sbjct: 154 TGDSSRVIAASYDKTVRAWDLETGKLLWKVR-YDTFIVSCKFSPDGKYVVSGFDVDHGIC 212
Query: 178 LWDIRKKAAIQTFQN--TYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTM-RGH 234
+ D + ++ T + + F+ S ++ S +D IK+WD+ T+ + H
Sbjct: 213 IMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAH 272
Query: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP--FAPKERCVKIFQGNVHNFEKNLLRCS 292
+++++ + G +L +++ D +++W+V F CV + QG+ E ++ C
Sbjct: 273 SNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGH----EGSVSSCH 328
Query: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLY 352
++ D S + +G DR V +WD L GH + +VA ++ I+SAS D+ +
Sbjct: 329 FARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMR 388
Query: 353 MGEIQ 357
+ I+
Sbjct: 389 LWNIE 393
Score = 77.0 bits (188), Expect = 2e-14
Identities = 46/169 (27%), Positives = 81/169 (47%), Gaps = 12/169 (7%)
Query: 65 HEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSML 124
H + C F P+ +AS DR I +W+V K HS A+ + G L
Sbjct: 229 HTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFL 288
Query: 125 FSASTDKTVAVWDSETGE------RVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKL 178
++S DK + +W+ TGE V ++GH V+SC+ AR L+ +G D TV +
Sbjct: 289 CTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLI-SGGFDRTVAI 347
Query: 179 WDIR---KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
WD+ +K +++ + V+ V ++ I+S D +++W++ +
Sbjct: 348 WDVAEGYRKLSLKGHND--WVMDVAISNNKKWILSASKDRTMRLWNIEE 394
Score = 62.0 bits (149), Expect = 8e-10
Identities = 31/83 (37%), Positives = 49/83 (59%), Gaps = 1/83 (1%)
Query: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELH 116
A + L+ GHEG V C F + S L S GFDR + +W+V + +LKGH+ VM++
Sbjct: 312 ACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV-AEGYRKLSLKGHNDWVMDVA 370
Query: 117 YNTDGSMLFSASTDKTVAVWDSE 139
+ + + SAS D+T+ +W+ E
Sbjct: 371 ISNNKKWILSASKDRTMRLWNIE 393
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 115 bits (289), Expect = 5e-26
Identities = 73/259 (28%), Positives = 134/259 (51%), Gaps = 10/259 (3%)
Query: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164
++ H+ AV ++ DG + S DKT+ V+ +ETGE++ +K H V C
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC-AFSTDD 669
Query: 165 QLVCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQII--SGGIDNDIKVWD 221
+ + T S D VK+W+ + T+ +++ QV F ++S ++ +G D +K+WD
Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729
Query: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC-VKIFQGN 280
L Q + TM GH +SV S + L S + D T+++WD ++ VK F N
Sbjct: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789
Query: 281 VHNFEKNL----LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
+ + ++++ CSWS DG++I + ++ +++W+T SR + GH ++ V F
Sbjct: 790 LEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFS 848
Query: 337 PDEPIIISASSDKRLYMGE 355
PD +++S D+ + + E
Sbjct: 849 PDGSSFLTSSDDQTIRLWE 867
Score = 92.4 bits (228), Expect = 5e-19
Identities = 84/340 (24%), Positives = 141/340 (41%), Gaps = 52/340 (15%)
Query: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHSGAVMELHY 117
++ + HE EV CC F + +A+ D+ + +WN + G+ + T HS V H+
Sbjct: 650 LLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVH--TYDEHSEQVNCCHF 707
Query: 118 NTDGS--MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP--QLVCTGSDD 173
+L + S+D + +WD E + GHT+ VN C R P +L+ + S D
Sbjct: 708 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC---RFSPDDKLLASCSAD 764
Query: 174 GTVKLWDI-----RKKAAIQTF-------QNTYQVLAVTFNDTSDQI-ISGGIDNDIKVW 220
GT+KLWD RK ++ F Q +V+ + ++D I N I +W
Sbjct: 765 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLW 824
Query: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP------KERCV 274
+ RGH V G+ S +GS L+++ D T+R+W+ + K+
Sbjct: 825 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVD 884
Query: 275 KIFQGNV-----------------------HNFEKNLLRCSWSPDGSKIAAGSADRFVYV 311
+FQ N + E + C SP IA G + + +
Sbjct: 885 VVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEI 944
Query: 312 WDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
+ + RI H ++ + F DE +IS+S D +
Sbjct: 945 LELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEI 984
Score = 90.1 bits (222), Expect = 3e-18
Identities = 76/317 (23%), Positives = 138/317 (43%), Gaps = 49/317 (15%)
Query: 69 VYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAS 128
V CC + +G+ + A ++ I LWN A +GH V + ++ DGS ++S
Sbjct: 801 VKCCSWSADGARIMVAAKNK-IFLWNT-DSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS 858
Query: 129 TDKTVAVWDSETG-----------------------------ERVKRLKGHTSFVN---- 155
D+T+ +W+++ R++ + G T ++
Sbjct: 859 DDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 918
Query: 156 ---SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISG 211
SC Q + G ++G +++ ++ Q+ FQ+ V + F +IS
Sbjct: 919 AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISS 978
Query: 212 GIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKE 271
D +I+VW+ + +K + +RGH ++V L + S LLS + D TV+VW++ KE
Sbjct: 979 SDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL-KNSRLLSWSFDGTVKVWNIIT-GNKE 1035
Query: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
+ QG V L C S D +K ++ SAD+ +W L++L GH G +
Sbjct: 1036 KDFVCHQGTV-------LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1088
Query: 332 EVAFHPDEPIIISASSD 348
AF D ++ + +
Sbjct: 1089 CSAFSVDSTLLATGDDN 1105
Score = 58.9 bits (141), Expect = 7e-09
Identities = 59/291 (20%), Positives = 115/291 (39%), Gaps = 11/291 (3%)
Query: 66 EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF 125
E +V CC P+ +A + I + + + + + H V + + D L
Sbjct: 918 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLI 976
Query: 126 SASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI---R 182
S+S D + VW+ + + + L+GH V + L + S DGTVK+W+I
Sbjct: 977 SSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIITGN 1033
Query: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
K+ Q T VL+ + + + S D K+W + +RGH V +
Sbjct: 1034 KEKDFVCHQGT--VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1091
Query: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
S + + L + + +R+W+V C + + + +SPDG +
Sbjct: 1092 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI- 1150
Query: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
SA ++ W+ + + ++ ++ PD ++ + LY+
Sbjct: 1151 -SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1200
Score = 38.1 bits (87), Expect = 0.012
Identities = 32/98 (32%), Positives = 44/98 (44%), Gaps = 15/98 (15%)
Query: 55 LQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-----C-----DNYAT 104
L P+ L GH G V C F + + LA+ + I +WNV C + AT
Sbjct: 1073 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1132
Query: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE 142
H G V +L ++ DG ML SA + W+ TGE
Sbjct: 1133 ---HGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGE 1165
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 115 bits (289), Expect = 5e-26
Identities = 73/259 (28%), Positives = 134/259 (51%), Gaps = 10/259 (3%)
Query: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164
++ H+ AV ++ DG + S DKT+ V+ +ETGE++ +K H V C
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCC-AFSTDD 658
Query: 165 QLVCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQII--SGGIDNDIKVWD 221
+ + T S D VK+W+ + T+ +++ QV F ++S ++ +G D +K+WD
Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718
Query: 222 LRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERC-VKIFQGN 280
L Q + TM GH +SV S + L S + D T+++WD ++ VK F N
Sbjct: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778
Query: 281 VHNFEKNL----LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFH 336
+ + ++++ CSWS DG++I + ++ +++W+T SR + GH ++ V F
Sbjct: 779 LEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLWNTDSRSKVADCRGHLSWVHGVMFS 837
Query: 337 PDEPIIISASSDKRLYMGE 355
PD +++S D+ + + E
Sbjct: 838 PDGSSFLTSSDDQTIRLWE 856
Score = 92.4 bits (228), Expect = 5e-19
Identities = 84/340 (24%), Positives = 141/340 (41%), Gaps = 52/340 (15%)
Query: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHSGAVMELHY 117
++ + HE EV CC F + +A+ D+ + +WN + G+ + T HS V H+
Sbjct: 639 LLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVH--TYDEHSEQVNCCHF 696
Query: 118 NTDGS--MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP--QLVCTGSDD 173
+L + S+D + +WD E + GHT+ VN C R P +L+ + S D
Sbjct: 697 TNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHC---RFSPDDKLLASCSAD 753
Query: 174 GTVKLWDI-----RKKAAIQTF-------QNTYQVLAVTFNDTSDQI-ISGGIDNDIKVW 220
GT+KLWD RK ++ F Q +V+ + ++D I N I +W
Sbjct: 754 GTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLW 813
Query: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAP------KERCV 274
+ RGH V G+ S +GS L+++ D T+R+W+ + K+
Sbjct: 814 NTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVD 873
Query: 275 KIFQGNV-----------------------HNFEKNLLRCSWSPDGSKIAAGSADRFVYV 311
+FQ N + E + C SP IA G + + +
Sbjct: 874 VVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEI 933
Query: 312 WDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
+ + RI H ++ + F DE +IS+S D +
Sbjct: 934 LELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEI 973
Score = 90.1 bits (222), Expect = 3e-18
Identities = 76/317 (23%), Positives = 138/317 (43%), Gaps = 49/317 (15%)
Query: 69 VYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSAS 128
V CC + +G+ + A ++ I LWN A +GH V + ++ DGS ++S
Sbjct: 790 VKCCSWSADGARIMVAAKNK-IFLWNT-DSRSKVADCRGHLSWVHGVMFSPDGSSFLTSS 847
Query: 129 TDKTVAVWDSETG-----------------------------ERVKRLKGHTSFVN---- 155
D+T+ +W+++ R++ + G T ++
Sbjct: 848 DDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTE 907
Query: 156 ---SCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISG 211
SC Q + G ++G +++ ++ Q+ FQ+ V + F +IS
Sbjct: 908 AQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISS 967
Query: 212 GIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKE 271
D +I+VW+ + +K + +RGH ++V L + S LLS + D TV+VW++ KE
Sbjct: 968 SDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL-KNSRLLSWSFDGTVKVWNIIT-GNKE 1024
Query: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
+ QG V L C S D +K ++ SAD+ +W L++L GH G +
Sbjct: 1025 KDFVCHQGTV-------LSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1077
Query: 332 EVAFHPDEPIIISASSD 348
AF D ++ + +
Sbjct: 1078 CSAFSVDSTLLATGDDN 1094
Score = 58.9 bits (141), Expect = 7e-09
Identities = 59/291 (20%), Positives = 115/291 (39%), Gaps = 11/291 (3%)
Query: 66 EGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLF 125
E +V CC P+ +A + I + + + + + H V + + D L
Sbjct: 907 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ-HKKTVWHIQFTADEKTLI 965
Query: 126 SASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI---R 182
S+S D + VW+ + + + L+GH V + L + S DGTVK+W+I
Sbjct: 966 SSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLLKNSRLL--SWSFDGTVKVWNIITGN 1022
Query: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
K+ Q T VL+ + + + S D K+W + +RGH V +
Sbjct: 1023 KEKDFVCHQGT--VLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSA 1080
Query: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302
S + + L + + +R+W+V C + + + +SPDG +
Sbjct: 1081 FSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLI- 1139
Query: 303 GSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYM 353
SA ++ W+ + + ++ ++ PD ++ + LY+
Sbjct: 1140 -SAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYI 1189
Score = 38.1 bits (87), Expect = 0.012
Identities = 32/98 (32%), Positives = 44/98 (44%), Gaps = 15/98 (15%)
Query: 55 LQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD-----C-----DNYAT 104
L P+ L GH G V C F + + LA+ + I +WNV C + AT
Sbjct: 1062 LLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAAT 1121
Query: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGE 142
H G V +L ++ DG ML SA + W+ TGE
Sbjct: 1122 ---HGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGE 1154
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 115 bits (288), Expect = 6e-26
Identities = 85/311 (27%), Positives = 149/311 (47%), Gaps = 28/311 (9%)
Query: 51 RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHS 109
R L++P +L GH+ V C G+ + S D + +W+ V G C TL GH+
Sbjct: 248 RRGELKSP-KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKC--LRTLVGHT 303
Query: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169
G V + ++ S STD+T+ VW++ETGE + L GHTS V + + V +
Sbjct: 304 GGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK---RVVS 358
Query: 170 GSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229
GS D T+++WDI + + D +++SG D +KVWD +
Sbjct: 359 GSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-GRRVVSGAYDFMVKVWDPETETCLH 417
Query: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289
T++GH + V SL +G +++S ++D ++RVWDV C+ G+ L
Sbjct: 418 TLQGHTNRV--YSLQFDGIHVVSGSLDTSIRVWDVE----TGNCIHTLTGH------QSL 465
Query: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG---HAGSINEVAFHPDEPIIISAS 346
+ + +G+AD V +WD + + L L G H ++ + F+ + +I++S
Sbjct: 466 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSS 523
Query: 347 SDKRLYMGEIQ 357
D + + +++
Sbjct: 524 DDGTVKLWDLK 534
Score = 38.5 bits (88), Expect = 0.009
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 10/93 (10%)
Query: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKG---HSGAVME 114
I L+GH+ + N L S D + +W++ G C TL+G H AV
Sbjct: 456 IHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC--LQTLQGPNKHQSAVTC 511
Query: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRL 147
L +N + + ++S D TV +WD +TGE ++ L
Sbjct: 512 LQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 542
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 115 bits (288), Expect = 6e-26
Identities = 85/311 (27%), Positives = 149/311 (47%), Gaps = 28/311 (9%)
Query: 51 RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHS 109
R L++P +L GH+ V C G+ + S D + +W+ V G C TL GH+
Sbjct: 366 RRGELKSP-KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKC--LRTLVGHT 421
Query: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169
G V + ++ S STD+T+ VW++ETGE + L GHTS V + + V +
Sbjct: 422 GGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK---RVVS 476
Query: 170 GSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229
GS D T+++WDI + + D +++SG D +KVWD +
Sbjct: 477 GSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-GRRVVSGAYDFMVKVWDPETETCLH 535
Query: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289
T++GH + V SL +G +++S ++D ++RVWDV C+ G+ L
Sbjct: 536 TLQGHTNRV--YSLQFDGIHVVSGSLDTSIRVWDVE----TGNCIHTLTGH------QSL 583
Query: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG---HAGSINEVAFHPDEPIIISAS 346
+ + +G+AD V +WD + + L L G H ++ + F+ + +I++S
Sbjct: 584 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSS 641
Query: 347 SDKRLYMGEIQ 357
D + + +++
Sbjct: 642 DDGTVKLWDLK 652
Score = 38.5 bits (88), Expect = 0.009
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 10/93 (10%)
Query: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKG---HSGAVME 114
I L+GH+ + N L S D + +W++ G C TL+G H AV
Sbjct: 574 IHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC--LQTLQGPNKHQSAVTC 629
Query: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRL 147
L +N + + ++S D TV +WD +TGE ++ L
Sbjct: 630 LQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 660
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 115 bits (288), Expect = 6e-26
Identities = 85/311 (27%), Positives = 149/311 (47%), Gaps = 28/311 (9%)
Query: 51 RCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWN-VYGDCDNYATLKGHS 109
R L++P +L GH+ V C G+ + S D + +W+ V G C TL GH+
Sbjct: 286 RRGELKSP-KVLKGHDDHVITC-LQFCGNRIVSGSDDNTLKVWSAVTGKC--LRTLVGHT 341
Query: 110 GAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCT 169
G V + ++ S STD+T+ VW++ETGE + L GHTS V + + V +
Sbjct: 342 GGVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK---RVVS 396
Query: 170 GSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTY 229
GS D T+++WDI + + D +++SG D +KVWD +
Sbjct: 397 GSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD-GRRVVSGAYDFMVKVWDPETETCLH 455
Query: 230 TMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLL 289
T++GH + V SL +G +++S ++D ++RVWDV C+ G+ L
Sbjct: 456 TLQGHTNRV--YSLQFDGIHVVSGSLDTSIRVWDVE----TGNCIHTLTGH------QSL 503
Query: 290 RCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPG---HAGSINEVAFHPDEPIIISAS 346
+ + +G+AD V +WD + + L L G H ++ + F+ + +I++S
Sbjct: 504 TSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSS 561
Query: 347 SDKRLYMGEIQ 357
D + + +++
Sbjct: 562 DDGTVKLWDLK 572
Score = 38.5 bits (88), Expect = 0.009
Identities = 29/93 (31%), Positives = 46/93 (49%), Gaps = 10/93 (10%)
Query: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKG---HSGAVME 114
I L+GH+ + N L S D + +W++ G C TL+G H AV
Sbjct: 494 IHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQC--LQTLQGPNKHQSAVTC 549
Query: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRL 147
L +N + + ++S D TV +WD +TGE ++ L
Sbjct: 550 LQFNKN--FVITSSDDGTVKLWDLKTGEFIRNL 580
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 112 bits (279), Expect = 7e-25
Identities = 65/206 (31%), Positives = 104/206 (50%), Gaps = 3/206 (1%)
Query: 61 LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120
+L GH G VY +F + S L S D I W++ G N +GH+ V +L +
Sbjct: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL-GSFTNTVLYQGHAYPVWDLDISPY 395
Query: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
S S D+T +W + ++ GH + V+ C + TGS D TV+LW
Sbjct: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD-CVKFHPNSNYLATGSTDKTVRLWS 454
Query: 181 IRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
++ +++ F + VL++ F+ + S G D +K+WDL L +RGH D++T
Sbjct: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
Query: 240 GLSLSSEGSYLLSNAMDNTVRVWDVR 265
L+ S + + S +MDN+VRVWD+R
Sbjct: 515 SLTFSPDSGLIASASMDNSVRVWDIR 540
Score = 85.9 bits (211), Expect = 5e-17
Identities = 76/285 (26%), Positives = 126/285 (44%), Gaps = 30/285 (10%)
Query: 79 STLASAGFDR-LILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD 137
S L +AGFD I LW++ + H V +H D + D+ D
Sbjct: 280 SKLLAAGFDNSCIKLWSLRS---KKLKSEPHQVDVSRIHLACD---ILEEEDDE-----D 328
Query: 138 SETGERVKRLKGHTSFVNSC-YPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQ 195
G +K L+GH V S + A L C S+D +++ WD+ +Q + Y
Sbjct: 329 DNAGTEMKILRGHCGPVYSTRFLADSSGLLSC--SEDMSIRYWDLGSFTNTVLYQGHAYP 386
Query: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR---GHADSVTGLSLSSEGSYLLS 252
V + + S SG D ++W + TY +R GH V + +YL +
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDR---TYPLRIYAGHLADVDCVKFHPNSNYLAT 443
Query: 253 NAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
+ D TVR+W A + V++F G+ +L ++SP+G +A+ D+ + +W
Sbjct: 444 GSTDKTVRLWS----AQQGNSVRLFTGH----RGPVLSLAFSPNGKYLASAGEDQRLKLW 495
Query: 313 DTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
D S + +L GH +I + F PD +I SAS D + + +I+
Sbjct: 496 DLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
Score = 83.6 bits (205), Expect = 3e-16
Identities = 43/126 (34%), Positives = 70/126 (55%), Gaps = 4/126 (3%)
Query: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
P+ + +GH +V C KFHPN + LA+ D+ + LW+ ++ GH G V+ L +
Sbjct: 418 PLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQ-QGNSVRLFTGHRGPVLSLAF 476
Query: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNS-CYPARRGPQLVCTGSDDGTV 176
+ +G L SA D+ + +WD +G K L+GHT + S + G L+ + S D +V
Sbjct: 477 SPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSG--LIASASMDNSV 534
Query: 177 KLWDIR 182
++WDIR
Sbjct: 535 RVWDIR 540
Score = 76.6 bits (187), Expect = 3e-14
Identities = 52/186 (27%), Positives = 84/186 (45%), Gaps = 9/186 (4%)
Query: 60 MLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLK---GHSGAVMELH 116
+L GH V+ P AS DR LW+ D L+ GH V +
Sbjct: 378 VLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSF----DRTYPLRIYAGHLADVDCVK 433
Query: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176
++ + + L + STDKTV +W ++ G V+ GH V S + G L G D +
Sbjct: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ-RL 492
Query: 177 KLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHA 235
KLWD+ + + +T + ++TF+ S I S +DN ++VWD+R + G +
Sbjct: 493 KLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSS 552
Query: 236 DSVTGL 241
+ G+
Sbjct: 553 SELVGV 558
>gi|7706657 cell division cycle 40 homolog [Homo sapiens]
Length = 579
Score = 108 bits (271), Expect = 6e-24
Identities = 78/296 (26%), Positives = 132/296 (44%), Gaps = 9/296 (3%)
Query: 49 PPRCSSLQAPIMLLSGHEGEVYCCKFHP-NGSTLASAGFDRLILLWNVYGDCDNYATLKG 107
P +C + I + SGH V + P +G L S D I LW VYG+ T G
Sbjct: 271 PEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGERRCLRTFIG 330
Query: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGH-TSFVNSCYPARRGPQL 166
HS AV ++ +NT G+ SA+ D+ + +WD+ETG+ + R + P L
Sbjct: 331 HSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNL 390
Query: 167 VCTGSDDGTVKLWDIRKKAAIQTF-QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR-Q 224
G D + WDIR +Q + ++ V + F D + + +S D ++VW+
Sbjct: 391 FVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIP 450
Query: 225 NKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVR-PFAPKERCVKIFQGNVHN 283
Y S+ ++LS G +L +MDN + ++ + F ++ KIF+G H
Sbjct: 451 VDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKK--KIFKG--HM 506
Query: 284 FEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDE 339
+ +SPD S + +G + + +WD + ++ + H +HP E
Sbjct: 507 VAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHE 562
Score = 59.3 bits (142), Expect = 5e-09
Identities = 39/152 (25%), Positives = 71/152 (46%), Gaps = 13/152 (8%)
Query: 208 IISGGIDNDIKVWDLR-QNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRP 266
++S +D IK+W++ + + T GH+ +V + ++ G+ LS A D +++WD
Sbjct: 304 LLSCSMDCKIKLWEVYGERRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTET 363
Query: 267 FAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK---IAAGSADRFVYVWDTTSRRILYKL 323
+C+ F K ++PD K AG +D+ + WD S I+ +
Sbjct: 364 ----GQCISRFTNR-----KVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEY 414
Query: 324 PGHAGSINEVAFHPDEPIIISASSDKRLYMGE 355
H G++N + F + +S S DK L + E
Sbjct: 415 DRHLGAVNTIVFVDENRRFVSTSDDKSLRVWE 446
Score = 42.0 bits (97), Expect = 8e-04
Identities = 29/109 (26%), Positives = 44/109 (40%), Gaps = 4/109 (3%)
Query: 76 PNGSTLASAGFDRLILLWNVYGD--CDNYATLKGH--SGAVMELHYNTDGSMLFSASTDK 131
PNG LA D IL++ + KGH +G ++ ++ D S + S +
Sbjct: 471 PNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNG 530
Query: 132 TVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
+ +WD +T + R K H V T DG +KLWD
Sbjct: 531 KLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD 579
>gi|153791298 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 108 bits (269), Expect = 1e-23
Identities = 76/293 (25%), Positives = 138/293 (47%), Gaps = 15/293 (5%)
Query: 56 QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMEL 115
Q + L +G V +F+ +G+ + G D+ + LWN T GH V++
Sbjct: 15 QKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGT-LLRTYSGHGYEVLDA 73
Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
+ D S L S DK V +WD +G+ V++ +GH VN+ ++ +GS D +
Sbjct: 74 AGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNT-VQFNEEATVILSGSIDSS 132
Query: 176 VKLWDIRKK--AAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232
++ WD R + +QT V +V +D +I++G +D ++ +DLR +L
Sbjct: 133 IRCWDCRSRRPEPVQTLDEARDGVSSVKVSD--HEILAGSVDGRVRRYDLRMGQLFSDYV 190
Query: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS 292
G +T S +G L +++D+T+R+ D K+ + + H ++ L C
Sbjct: 191 G--SPITCTCFSRDGQCTLVSSLDSTLRLLD------KDTGELLGEYKGHKNQEYKLDCC 242
Query: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
S + + + S D V+ WD + LP +G + +A+HP EP +++A
Sbjct: 243 LSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA 295
Score = 60.5 bits (145), Expect = 2e-09
Identities = 32/115 (27%), Positives = 62/115 (53%), Gaps = 8/115 (6%)
Query: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296
+V + + +G+Y L+ D T+++W+ + ++ + G H +E +L + S D
Sbjct: 27 AVRAVRFNVDGNYCLTCGSDKTLKLWNPL----RGTLLRTYSG--HGYE--VLDAAGSFD 78
Query: 297 GSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
S + +G D+ V +WD S +++ K GHAG +N V F+ + +I+S S D +
Sbjct: 79 NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSI 133
>gi|14150114 mitogen-activated protein kinase organizer 1 [Homo
sapiens]
Length = 315
Score = 108 bits (269), Expect = 1e-23
Identities = 76/293 (25%), Positives = 138/293 (47%), Gaps = 15/293 (5%)
Query: 56 QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMEL 115
Q + L +G V +F+ +G+ + G D+ + LWN T GH V++
Sbjct: 15 QKRLKTLDCGQGAVRAVRFNVDGNYCLTCGSDKTLKLWNPLRGT-LLRTYSGHGYEVLDA 73
Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
+ D S L S DK V +WD +G+ V++ +GH VN+ ++ +GS D +
Sbjct: 74 AGSFDNSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNT-VQFNEEATVILSGSIDSS 132
Query: 176 VKLWDIRKK--AAIQTFQNTYQ-VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232
++ WD R + +QT V +V +D +I++G +D ++ +DLR +L
Sbjct: 133 IRCWDCRSRRPEPVQTLDEARDGVSSVKVSD--HEILAGSVDGRVRRYDLRMGQLFSDYV 190
Query: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCS 292
G +T S +G L +++D+T+R+ D K+ + + H ++ L C
Sbjct: 191 G--SPITCTCFSRDGQCTLVSSLDSTLRLLD------KDTGELLGEYKGHKNQEYKLDCC 242
Query: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA 345
S + + + S D V+ WD + LP +G + +A+HP EP +++A
Sbjct: 243 LSERDTHVVSCSEDGKVFFWDLVEGALALALPVGSGVVQSLAYHPTEPCLLTA 295
Score = 60.5 bits (145), Expect = 2e-09
Identities = 32/115 (27%), Positives = 62/115 (53%), Gaps = 8/115 (6%)
Query: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296
+V + + +G+Y L+ D T+++W+ + ++ + G H +E +L + S D
Sbjct: 27 AVRAVRFNVDGNYCLTCGSDKTLKLWNPL----RGTLLRTYSG--HGYE--VLDAAGSFD 78
Query: 297 GSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRL 351
S + +G D+ V +WD S +++ K GHAG +N V F+ + +I+S S D +
Sbjct: 79 NSSLCSGGGDKAVVLWDVASGQVVRKFRGHAGKVNTVQFNEEATVILSGSIDSSI 133
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 107 bits (267), Expect = 2e-23
Identities = 84/304 (27%), Positives = 135/304 (44%), Gaps = 31/304 (10%)
Query: 62 LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDG 121
L GH V F P G LAS D + W++ + ++ T KGH V+ + ++ DG
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHF-TCKGHRHWVLSISWSPDG 168
Query: 122 SMLFSASTDKTVAVWDSETGERVKR-LKGHTSFVN--SCYPARRGPQ--LVCTGSDDGTV 176
L S + + +WD TG++V R L GH+ ++ S P P+ V + S DG+V
Sbjct: 169 RKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSV 228
Query: 177 KLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHAD 236
++WD + Q + + S D IKVW L T++GH
Sbjct: 229 RIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCRTLQGHGH 288
Query: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCV--KIFQGNVHNFEK------NL 288
V ++LS++ Y L F P E V + QG++ ++ NL
Sbjct: 289 WVNTMALSTD--YALRTG-----------AFEPAEASVNPQDLQGSLQELKERALSRYNL 335
Query: 289 LRCSWSPDGSKIAAGSADRFVYVWD-TTSRRILYKLPGHAGSINEVAFHPDEPIIISASS 347
+R ++ +GS D +++W ++ L ++ GH IN+V F PD I+ SAS
Sbjct: 336 VR---GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASF 392
Query: 348 DKRL 351
DK +
Sbjct: 393 DKSI 396
Score = 104 bits (260), Expect = 1e-22
Identities = 76/282 (26%), Positives = 128/282 (45%), Gaps = 55/282 (19%)
Query: 75 HPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTV 133
+P +AS+ D + +W+ G C+ T GH+ +V L + DG +L+SAS D+T+
Sbjct: 213 NPECRYVASSSKDGSVRIWDTTAGRCERILT--GHTQSVTCLRWGGDG-LLYSASQDRTI 269
Query: 134 AVWDSETGERVKRLKGHTSFVNSC-----YPAR--------------------------- 161
VW + G + L+GH +VN+ Y R
Sbjct: 270 KVWRAHDGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERA 329
Query: 162 ---------RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQVLA--VTFNDTSDQIIS 210
+GP+ + +GSDD T+ LW + T +Q L V F+ S + S
Sbjct: 330 LSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVAS 389
Query: 211 GGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPK 270
D IK+WD R K ++RGH +V ++ S++ L+S + D+T++VWDV+
Sbjct: 390 ASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVK----A 445
Query: 271 ERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312
++ G+ + WSPDG ++A+G D+ + +W
Sbjct: 446 QKLAMDLPGHA----DEVYAVDWSPDGQRVASGGKDKCLRIW 483
Score = 67.0 bits (162), Expect = 2e-11
Identities = 37/113 (32%), Positives = 63/113 (55%), Gaps = 9/113 (7%)
Query: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285
+ T ++ GH+++V ++ S G YL S + D TVR WD+ P C +G+ H
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC----KGHRH--- 157
Query: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWD-TTSRRILYKLPGHAGSINEVAFHP 337
+L SWSPDG K+A+G + + +WD +T +++ L GH+ I +++ P
Sbjct: 158 -WVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEP 209
Score = 38.5 bits (88), Expect = 0.009
Identities = 36/154 (23%), Positives = 66/154 (42%), Gaps = 11/154 (7%)
Query: 195 QVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT-------GLSLSSEG 247
Q L V F D Q++ D + + R + + D + +SS G
Sbjct: 15 QRLLVQFQDEGGQLLGSPFDVPVDITPDRLQLVCNALLAQEDPLPLAFFVHDAEIVSSLG 74
Query: 248 SYLLSNAMDNTVRVWDV--RPFAP-KERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGS 304
L S A++ T +V D+ +P A + R V ++ + ++ ++SP G +A+GS
Sbjct: 75 KTLESQAVE-TEKVLDIIYQPQAIFRVRAVTRCTSSLEGHSEAVISVAFSPTGKYLASGS 133
Query: 305 ADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD 338
D V WD ++ + GH + +++ PD
Sbjct: 134 GDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPD 167
Score = 33.5 bits (75), Expect = 0.30
Identities = 14/34 (41%), Positives = 20/34 (58%)
Query: 60 MLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLW 93
M L GH EVY + P+G +AS G D+ + +W
Sbjct: 450 MDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 106 bits (265), Expect = 3e-23
Identities = 61/209 (29%), Positives = 103/209 (49%), Gaps = 9/209 (4%)
Query: 59 IMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATL---KGHSGAVMEL 115
+ +L GH G VY F P+ + L S+ D + LW++ + L KGH+ V +
Sbjct: 536 LKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSL----QTFTCLVGYKGHNYPVWDT 591
Query: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
++ G S D+ +W ++ + ++ GH + VN C V TGS D T
Sbjct: 592 QFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVN-CTRFHPNSNYVATGSADRT 650
Query: 176 VKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGH 234
V+LWD+ ++ F + + ++TF+ + +G D + +WD+ + ++GH
Sbjct: 651 VRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGH 710
Query: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWD 263
D+V L S +G L S +MDNTVR+WD
Sbjct: 711 TDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 90.9 bits (224), Expect = 2e-18
Identities = 53/156 (33%), Positives = 85/156 (54%), Gaps = 5/156 (3%)
Query: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY-GDCDNYATLKGHSGAVMELH 116
P+ + +GH +V C +FHPN + +A+ DR + LW+V G+C T GH G + L
Sbjct: 619 PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRIFT--GHKGPIHSLT 676
Query: 117 YNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTV 176
++ +G L + +TD V +WD G V LKGHT V S +R G +++ +GS D TV
Sbjct: 677 FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDG-EILASGSMDNTV 735
Query: 177 KLWD-IRKKAAIQTFQNTYQVLAVTFNDTSDQIISG 211
+LWD I+ ++T T + + S +++ G
Sbjct: 736 RLWDAIKAFEDLETDDFTTATGHINLPENSQELLLG 771
Score = 89.7 bits (221), Expect = 4e-18
Identities = 64/236 (27%), Positives = 108/236 (45%), Gaps = 20/236 (8%)
Query: 119 TDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQ--LVCTGSDDGTV 176
+D S++ S D + D +T +K L GH+ V Y A P + + S+DGTV
Sbjct: 511 SDLSLIDKESDDVLERIMDEKTASELKILYGHSGPV---YGASFSPDRNYLLSSSEDGTV 567
Query: 177 KLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHA 235
+LW ++ + ++ + Y V F+ +SGG D ++W + GH
Sbjct: 568 RLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHL 627
Query: 236 DSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN---VHNFEKNLLRCS 292
V +Y+ + + D TVR+WDV CV+IF G+ +H+ +
Sbjct: 628 ADVNCTRFHPNSNYVATGSADRTVRLWDVL----NGNCVRIFTGHKGPIHSL-------T 676
Query: 293 WSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
+SP+G +A G+ D V +WD ++ +L GH ++ + F D I+ S S D
Sbjct: 677 FSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMD 732
Score = 81.3 bits (199), Expect = 1e-15
Identities = 55/210 (26%), Positives = 89/210 (42%), Gaps = 10/210 (4%)
Query: 105 LKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGP 164
L GHSG V ++ D + L S+S D TV +W +T + KGH V + G
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 165 QLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLR 223
V +G D +LW ++ F + V F+ S+ + +G D +++WD+
Sbjct: 599 YFV-SGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVL 657
Query: 224 QNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHN 283
GH + L+ S G +L + A D V +WD+ + G +
Sbjct: 658 NGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH--------GLMVGELKG 709
Query: 284 FEKNLLRCSWSPDGSKIAAGSADRFVYVWD 313
+ +S DG +A+GS D V +WD
Sbjct: 710 HTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 80.1 bits (196), Expect = 3e-15
Identities = 60/256 (23%), Positives = 114/256 (44%), Gaps = 22/256 (8%)
Query: 102 YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR 161
Y L + G + + D S++ D TV VW S T ++++ +K +
Sbjct: 464 YTFLNAYQG-LTAVDVTDDSSLIAGGFADSTVRVW-SVTPKKLRSVKQASDL-------- 513
Query: 162 RGPQLVCTGSDDGTVKLWDIRKKAAIQT-FQNTYQVLAVTFNDTSDQIISGGIDNDIKVW 220
L+ SDD ++ D + + ++ + ++ V +F+ + ++S D +++W
Sbjct: 514 ---SLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW 570
Query: 221 DLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 280
L+ +GH V S G Y +S D R+W + P ++IF G
Sbjct: 571 SLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQP----LRIFAG- 625
Query: 281 VHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEP 340
H + N R + P+ + +A GSADR V +WD + + GH G I+ + F P+
Sbjct: 626 -HLADVNCTR--FHPNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGR 682
Query: 341 IIISASSDKRLYMGEI 356
+ + ++D R+ + +I
Sbjct: 683 FLATGATDGRVLLWDI 698
Score = 43.1 bits (100), Expect = 4e-04
Identities = 32/129 (24%), Positives = 51/129 (39%), Gaps = 19/129 (14%)
Query: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNL 288
YT +T + ++ + S + D+TVRVW V P K L
Sbjct: 464 YTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTP-------------------KKL 504
Query: 289 LRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
+ D S I S D + D + L L GH+G + +F PD ++S+S D
Sbjct: 505 RSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSED 564
Query: 349 KRLYMGEIQ 357
+ + +Q
Sbjct: 565 GTVRLWSLQ 573
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 105 bits (261), Expect = 8e-23
Identities = 75/295 (25%), Positives = 144/295 (48%), Gaps = 31/295 (10%)
Query: 68 EVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSA 127
+V ++ G+ LA+ +D +W G+ + TL H G + L +N G+ + SA
Sbjct: 227 DVTSLDWNSEGTLLATGSYDGFARIWTKDGNLAS--TLGQHKGPIFALKWNKKGNFILSA 284
Query: 128 STDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR----RGPQLVCTGSDDGTVKLWDIRK 183
DKT +WD+ TGE ++ H++ PA + + S D + + + +
Sbjct: 285 GVDKTTIIWDAHTGEAKQQFPFHSA------PALDVDWQSNNTFASCSTDMCIHVCKLGQ 338
Query: 184 KAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242
I+TFQ +T +V A+ ++ T + + S D +K+W ++Q+ + ++ H + +
Sbjct: 339 DRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIK 398
Query: 243 LSSEGS---------YLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSW 293
S G L S + D+TVR+WDV +R + I H ++ + ++
Sbjct: 399 WSPTGPGTNNPNANLMLASASFDSTVRLWDV------DRGICIHTLTKH--QEPVYSVAF 450
Query: 294 SPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSD 348
SPDG +A+GS D+ V++W+T + +++ G G I EV ++ + +++SD
Sbjct: 451 SPDGRYLASGSFDKCVHIWNTQTGALVHSYRG-TGGIFEVCWNAAGDKVGASASD 504
Score = 72.4 bits (176), Expect = 6e-13
Identities = 49/176 (27%), Positives = 83/176 (47%), Gaps = 11/176 (6%)
Query: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
PI GH EV K+ P G+ LAS D + +W++ D + L+ H+ + + +
Sbjct: 341 PIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQD-NCVHDLQAHNKEIYTIKW 399
Query: 118 NTDGS---------MLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC 168
+ G ML SAS D TV +WD + G + L H V S + G + +
Sbjct: 400 SPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDG-RYLA 458
Query: 169 TGSDDGTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ 224
+GS D V +W+ + A + +++ T + V +N D++ + D + V DLR+
Sbjct: 459 SGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK 514
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 104 bits (260), Expect = 1e-22
Identities = 82/307 (26%), Positives = 143/307 (46%), Gaps = 28/307 (9%)
Query: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
G + + C F PN LA+A + L LW+V DC+ TL+GH+ V + ++ ++
Sbjct: 229 GDDRPISYCHFSPNSKMLATACWSGLCKLWSV-PDCNLLHTLRGHNTNVGAIVFHPKSTV 287
Query: 124 --------LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSC--YPARRGPQLVCTGSDD 173
L S + D +V +W ++ E V ++GHT V +P+ R C D
Sbjct: 288 SLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCY---D 344
Query: 174 GTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR 232
+ +LWD+ + I + ++ V + F+ +GG+D +VWDLR + +
Sbjct: 345 RSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLE 404
Query: 233 GHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLR-C 291
GH + G++ S G ++ + + DNT +VWD+R + RCV + +NL+
Sbjct: 405 GHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR----QRRCVYTIPAH-----QNLVTGV 455
Query: 292 SWSP-DGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK- 349
+ P G+ + G+ D +W L L GH G + + D +I + S D+
Sbjct: 456 KFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRT 515
Query: 350 -RLYMGE 355
+L+M E
Sbjct: 516 FKLWMAE 522
Score = 97.4 bits (241), Expect = 2e-20
Identities = 59/207 (28%), Positives = 99/207 (47%), Gaps = 4/207 (1%)
Query: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117
P+ + GH V +HP+G L + +DR LW++ + +GHS V ++ +
Sbjct: 315 PVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQ-EEILHQEGHSMGVYDIAF 373
Query: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVK 177
+ DGS+ + D VWD TG + L+GH + + G + TGS D T K
Sbjct: 374 HQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH-IATGSGDNTCK 432
Query: 178 LWDIRKKAAIQTF-QNTYQVLAVTFNDT-SDQIISGGIDNDIKVWDLRQNKLTYTMRGHA 235
+WD+R++ + T + V V F + +++G DN K+W T+ GH
Sbjct: 433 VWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHE 492
Query: 236 DSVTGLSLSSEGSYLLSNAMDNTVRVW 262
V GL +SS+G + + + D T ++W
Sbjct: 493 GKVMGLDISSDGQLIATCSYDRTFKLW 519
Score = 88.2 bits (217), Expect = 1e-17
Identities = 61/246 (24%), Positives = 107/246 (43%), Gaps = 16/246 (6%)
Query: 100 DNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCY- 158
+N+ + G + H++ + ML +A +W + L+GH + V +
Sbjct: 222 NNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVF 281
Query: 159 ----PARRGPQLVCTGS--DDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISG 211
P+ V S DG+VKLW + + + +T +V V ++ + + +
Sbjct: 282 HPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTT 341
Query: 212 GIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKE 271
D ++WDL + GH+ V ++ +GS + +D RVWD+R
Sbjct: 342 CYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLR----TG 397
Query: 272 RCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSIN 331
RC+ +G++ K + ++SP+G IA GS D VWD RR +Y +P H +
Sbjct: 398 RCIMFLEGHL----KEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVT 453
Query: 332 EVAFHP 337
V F P
Sbjct: 454 GVKFEP 459
Score = 33.1 bits (74), Expect = 0.39
Identities = 13/37 (35%), Positives = 21/37 (56%)
Query: 57 APIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLW 93
+P+ L+GHEG+V +G +A+ +DR LW
Sbjct: 483 SPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519
>gi|16445438 bromodomain and WD repeat domain containing 1 isoform B
[Homo sapiens]
Length = 2269
Score = 103 bits (258), Expect = 2e-22
Identities = 80/317 (25%), Positives = 148/317 (46%), Gaps = 26/317 (8%)
Query: 64 GHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSM 123
GH VYC F G + + D L+ +W+ + +TL+GHS + ++ N + +M
Sbjct: 184 GHLSAVYCVAFDRTGHRIFTGSDDCLVKIWSTHNG-RLLSTLRGHSAEISDMAVNYENTM 242
Query: 124 LFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCY--PARRGPQ--LVCTGSDDGTVKL- 178
+ + S DK + VW T V L+GHT + S P +G Q +V TG+ DGTV
Sbjct: 243 IAAGSCDKIIRVWCLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGA-DGTVCFW 301
Query: 179 -WDIRK-KAAIQTFQNT------YQVLAVTFNDTSDQIISGGIDNDIKVWDL--RQNKLT 228
WD+ K + + + T Q+L +F+ + +G D+ I+++ L +
Sbjct: 302 QWDLESLKFSPRPLKFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKI 361
Query: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKI---FQGNVHNFE 285
+ H D V + + G LS + D T R+W + + + G++ + E
Sbjct: 362 AELESHTDKVDSIQFCNNGDRFLSGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEE 421
Query: 286 KNLLR-----CSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHP-DE 339
+ ++ +W+ + S + D + VW++ + ++L+ L GHA + + HP D
Sbjct: 422 ERFMKPKVTMIAWNQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDS 481
Query: 340 PIIISASSDKRLYMGEI 356
I++SA D +++ +I
Sbjct: 482 RIMLSAGHDGSIFIWDI 498
Score = 75.9 bits (185), Expect = 5e-14
Identities = 71/328 (21%), Positives = 134/328 (40%), Gaps = 41/328 (12%)
Query: 52 CSSLQAPIMLLSGHEGEVYCCKFHP--NGST--LASAGFDRLILLWNVYGDCDNYA---- 103
C AP+ +L GH G + +F P GS + S G D + W + ++
Sbjct: 256 CLRTCAPVAVLQGHTGSITSLQFSPMAKGSQRYMVSTGADGTVCFWQWDLESLKFSPRPL 315
Query: 104 --TLKGHSGAVMEL-HYNTDGSMLFSASTDKTVAVW--DSETGERVKRLKGHTSFVNSCY 158
T K G M ++ G L + STD + ++ E E++ L+ HT V+S
Sbjct: 316 KFTEKPRPGVQMLCSSFSVGGMFLATGSTDHVIRMYFLGFEAPEKIAELESHTDKVDSIQ 375
Query: 159 PARRGPQLVCTGSDDGTVKLWDI--------------RKKAAIQTFQNTY---QVLAVTF 201
G + + +GS DGT ++W R + + + + +V + +
Sbjct: 376 FCNNGDRFL-SGSRDGTARIWRFEQLEWRSILLDMATRISGDLSSEEERFMKPKVTMIAW 434
Query: 202 NDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSS-EGSYLLSNAMDNTVR 260
N +++ D+ +KVW+ +L + + GHAD V L + +LS D ++
Sbjct: 435 NQNDSIVVTAVNDHVLKVWNSYTGQLLHNLMGHADEVFVLETHPFDSRIMLSAGHDGSIF 494
Query: 261 VWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320
+WD+ + + +G H + C +S DG A + + ++ +
Sbjct: 495 IWDITKGTKMKHYFNMIEGQGHG---AVFDCKFSQDGQHFACTDSHGHLLIFGFGCSKPY 551
Query: 321 YKLPGHAGSINEVAFHPDEPIIISASSD 348
K+P +++ FH D +I S++
Sbjct: 552 EKIP------DQMFFHTDYRPLIRDSNN 573
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,898,340
Number of Sequences: 37866
Number of extensions: 700353
Number of successful extensions: 6568
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 272
Number of HSP's successfully gapped in prelim test: 78
Number of HSP's that attempted gapping in prelim test: 2089
Number of HSP's gapped (non-prelim): 1691
length of query: 357
length of database: 18,247,518
effective HSP length: 103
effective length of query: 254
effective length of database: 14,347,320
effective search space: 3644219280
effective search space used: 3644219280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.