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Search of human proteins with 219842266
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|219842266 usherin isoform B [Homo sapiens]
(5202 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|219842266 usherin isoform B [Homo sapiens] 1.083e+04 0.0
gi|219842259 usherin isoform A [Homo sapiens] 3284 0.0
gi|21264602 laminin alpha 5 [Homo sapiens] 394 e-108
gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens] 325 7e-88
gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens] 325 7e-88
gi|62868217 laminin, beta 3 precursor [Homo sapiens] 298 1e-79
gi|62868215 laminin, beta 3 precursor [Homo sapiens] 298 1e-79
gi|189083719 laminin, beta 3 precursor [Homo sapiens] 298 1e-79
gi|167614504 laminin, beta 1 precursor [Homo sapiens] 277 2e-73
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 275 7e-73
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 275 7e-73
gi|119703755 laminin, beta 2 precursor [Homo sapiens] 271 9e-72
gi|38788416 laminin, alpha 1 precursor [Homo sapiens] 264 2e-69
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 263 3e-69
gi|143770880 laminin, beta 4 [Homo sapiens] 251 1e-65
gi|145309326 laminin, gamma 1 precursor [Homo sapiens] 245 7e-64
gi|110611156 laminin, gamma 3 precursor [Homo sapiens] 231 1e-59
gi|222352127 sidekick 2 [Homo sapiens] 209 4e-53
gi|93204871 netrin 4 [Homo sapiens] 197 3e-49
gi|148613884 netrin 1 [Homo sapiens] 196 7e-49
gi|119220552 sidekick 1 [Homo sapiens] 194 3e-48
gi|5453810 netrin 3 [Homo sapiens] 163 5e-39
gi|122937440 multiple EGF-like-domains 9 [Homo sapiens] 162 6e-39
gi|181336739 multiple EGF-like-domains 11 [Homo sapiens] 155 1e-36
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 149 9e-35
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 149 9e-35
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens] 146 5e-34
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s... 146 6e-34
gi|205360934 fibronectin type III domain containing 3B [Homo sap... 145 8e-34
gi|205360932 fibronectin type III domain containing 3B [Homo sap... 145 8e-34
>gi|219842266 usherin isoform B [Homo sapiens]
Length = 5202
Score = 1.083e+04 bits (28097), Expect = 0.0
Identities = 5202/5202 (100%), Positives = 5202/5202 (100%)
Query: 1 MNCPVLSLGSGFLFQVIEMLIFAYFASISLTESRGLFPRLENVGAFKKVSIVPTQAVCGL 60
MNCPVLSLGSGFLFQVIEMLIFAYFASISLTESRGLFPRLENVGAFKKVSIVPTQAVCGL
Sbjct: 1 MNCPVLSLGSGFLFQVIEMLIFAYFASISLTESRGLFPRLENVGAFKKVSIVPTQAVCGL 60
Query: 61 PDRSTFCHSSAAAESIQFCTQRFCIQDCPYRSSHPTYTALFSAGLSSCITPDKNDLHPNA 120
PDRSTFCHSSAAAESIQFCTQRFCIQDCPYRSSHPTYTALFSAGLSSCITPDKNDLHPNA
Sbjct: 61 PDRSTFCHSSAAAESIQFCTQRFCIQDCPYRSSHPTYTALFSAGLSSCITPDKNDLHPNA 120
Query: 121 HSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQGVMCVIEKTVDGQIVFKLTIS 180
HSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQGVMCVIEKTVDGQIVFKLTIS
Sbjct: 121 HSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQGVMCVIEKTVDGQIVFKLTIS 180
Query: 181 EKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTPFNAR 240
EKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTPFNAR
Sbjct: 181 EKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTPFNAR 240
Query: 241 TLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQS 300
TLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQS
Sbjct: 241 TLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQS 300
Query: 301 HCRCPGSHPRVHPLAQRYCIPNDAGDTADNRVSRLNPEAHPLSFVNDNDVGTSWVSNVFT 360
HCRCPGSHPRVHPLAQRYCIPNDAGDTADNRVSRLNPEAHPLSFVNDNDVGTSWVSNVFT
Sbjct: 301 HCRCPGSHPRVHPLAQRYCIPNDAGDTADNRVSRLNPEAHPLSFVNDNDVGTSWVSNVFT 360
Query: 361 NITQLNQGVTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNCG 420
NITQLNQGVTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNCG
Sbjct: 361 NITQLNQGVTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNCG 420
Query: 421 AFGMKNNGDLEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFV 480
AFGMKNNGDLEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFV
Sbjct: 421 AFGMKNNGDLEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFV 480
Query: 481 KATQIRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQ 540
KATQIRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQ
Sbjct: 481 KATQIRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQ 540
Query: 541 ESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRG 600
ESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRG
Sbjct: 541 ESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRG 600
Query: 601 GGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG 660
GGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG
Sbjct: 601 GGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG 660
Query: 661 QCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKAN 720
QCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKAN
Sbjct: 661 QCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKAN 720
Query: 721 VIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTC 780
VIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTC
Sbjct: 721 VIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTC 780
Query: 781 RENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNN 840
RENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNN
Sbjct: 781 RENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNN 840
Query: 841 SFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMC 900
SFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMC
Sbjct: 841 SFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMC 900
Query: 901 ECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVN 960
ECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVN
Sbjct: 901 ECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVN 960
Query: 961 HICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQ 1020
HICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQ
Sbjct: 961 HICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQ 1020
Query: 1021 CFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSP 1080
CFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSP
Sbjct: 1021 CFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSP 1080
Query: 1081 NAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVT 1140
NAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVT
Sbjct: 1081 NAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVT 1140
Query: 1141 YKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEG 1200
YKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEG
Sbjct: 1141 YKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEG 1200
Query: 1201 HETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELH 1260
HETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELH
Sbjct: 1201 HETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELH 1260
Query: 1261 VEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPP 1320
VEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPP
Sbjct: 1261 VEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPP 1320
Query: 1321 QTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNI 1380
QTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNI
Sbjct: 1321 QTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNI 1380
Query: 1381 SWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIY 1440
SWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIY
Sbjct: 1381 SWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIY 1440
Query: 1441 EFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIY 1500
EFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIY
Sbjct: 1441 EFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIY 1500
Query: 1501 QLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFA 1560
QLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFA
Sbjct: 1501 QLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFA 1560
Query: 1561 ASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQ 1620
ASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQ
Sbjct: 1561 ASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQ 1620
Query: 1621 ITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMK 1680
ITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMK
Sbjct: 1621 ITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMK 1680
Query: 1681 NYNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEI 1740
NYNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEI
Sbjct: 1681 NYNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEI 1740
Query: 1741 SFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKW 1800
SFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKW
Sbjct: 1741 SFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKW 1800
Query: 1801 NKVIIKKEGSFISASVNGLMKHASESGDQPLVVNSPVYVGGIPQELLNSYQHLCLEQGFG 1860
NKVIIKKEGSFISASVNGLMKHASESGDQPLVVNSPVYVGGIPQELLNSYQHLCLEQGFG
Sbjct: 1801 NKVIIKKEGSFISASVNGLMKHASESGDQPLVVNSPVYVGGIPQELLNSYQHLCLEQGFG 1860
Query: 1861 GCMKDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAVNCRGNDSILVYQGKEQSVYEGG 1920
GCMKDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAVNCRGNDSILVYQGKEQSVYEGG
Sbjct: 1861 GCMKDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAVNCRGNDSILVYQGKEQSVYEGG 1920
Query: 1921 LQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVV 1980
LQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVV
Sbjct: 1921 LQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVV 1980
Query: 1981 RGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAGC 2040
RGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAGC
Sbjct: 1981 RGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAGC 2040
Query: 2041 TESSHALNISTPQEAPQEVQPPVAKSLPSSLLLSWNPPKKANGIITQYCLYMDGRLIYSG 2100
TESSHALNISTPQEAPQEVQPPVAKSLPSSLLLSWNPPKKANGIITQYCLYMDGRLIYSG
Sbjct: 2041 TESSHALNISTPQEAPQEVQPPVAKSLPSSLLLSWNPPKKANGIITQYCLYMDGRLIYSG 2100
Query: 2101 SEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPVLTVLDSRTIH 2160
SEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPVLTVLDSRTIH
Sbjct: 2101 SEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPVLTVLDSRTIH 2160
Query: 2161 IQWKQPRKISGILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGA 2220
IQWKQPRKISGILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGA
Sbjct: 2161 IQWKQPRKISGILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGA 2220
Query: 2221 CTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSYGLYLDG 2280
CTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSYGLYLDG
Sbjct: 2221 CTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSYGLYLDG 2280
Query: 2281 ILIHNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPLVENRTLEAPPEGTVNVFVKTQ 2340
ILIHNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPLVENRTLEAPPEGTVNVFVKTQ
Sbjct: 2281 ILIHNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPLVENRTLEAPPEGTVNVFVKTQ 2340
Query: 2341 GSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLID 2400
GSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLID
Sbjct: 2341 GSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLID 2400
Query: 2401 GLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPAR 2460
GLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPAR
Sbjct: 2401 GLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPAR 2460
Query: 2461 NNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAH 2520
NNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAH
Sbjct: 2461 NNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAH 2520
Query: 2521 SSWIPFMTAEDKPGPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPG 2580
SSWIPFMTAEDKPGPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPG
Sbjct: 2521 SSWIPFMTAEDKPGPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPG 2580
Query: 2581 NVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSV 2640
NVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSV
Sbjct: 2581 NVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSV 2640
Query: 2641 IISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRV 2700
IISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRV
Sbjct: 2641 IISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRV 2700
Query: 2701 LMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIH 2760
LMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIH
Sbjct: 2701 LMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIH 2760
Query: 2761 MPDPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTV 2820
MPDPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTV
Sbjct: 2761 MPDPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTV 2820
Query: 2821 PQNVGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIY 2880
PQNVGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIY
Sbjct: 2821 PQNVGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIY 2880
Query: 2881 SGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTA 2940
SGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTA
Sbjct: 2881 SGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTA 2940
Query: 2941 IDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVF 3000
IDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVF
Sbjct: 2941 IDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVF 3000
Query: 3001 NGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNK 3060
NGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNK
Sbjct: 3001 NGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNK 3060
Query: 3061 LYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRG 3120
LYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRG
Sbjct: 3061 LYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTPTIRG 3120
Query: 3121 ITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKPESIC 3180
ITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKPESIC
Sbjct: 3121 ITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQKPESIC 3180
Query: 3181 GHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGY 3240
GHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGY
Sbjct: 3181 GHICYSSEAKVCCNGVLYNPKPGHRCCEEKYIPFVLNSTGVCCGGRIQEAQPNHQCCSGY 3240
Query: 3241 YARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGRQIV 3300
YARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGRQIV
Sbjct: 3241 YARILPGEVCCPDEQHNRVSVGIGDSCCGRMPYSTSGNQICCAGRLHDGHGQKCCGRQIV 3300
Query: 3301 SNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPVKCCE 3360
SNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPVKCCE
Sbjct: 3301 SNDLECCGGEEGVVYNRLPGMFCCGQDYVNMSDTICCSASSGESKAHIKKNDPVPVKCCE 3360
Query: 3361 TELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNF 3420
TELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNF
Sbjct: 3361 TELIPKSQKCCNGVGYNPLKYVCSDKISTGMMMKETKECRILCPASMEATEHCGRCDFNF 3420
Query: 3421 TSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWN 3480
TSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWN
Sbjct: 3421 TSHICTVIRGSHNSTGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWN 3480
Query: 3481 SYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNG 3540
SYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNG
Sbjct: 3481 SYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNG 3540
Query: 3541 IERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITA 3600
IERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITA
Sbjct: 3541 IERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITA 3600
Query: 3601 LSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTA 3660
LSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTA
Sbjct: 3601 LSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTA 3660
Query: 3661 CTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRN 3720
CTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRN
Sbjct: 3661 CTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRN 3720
Query: 3721 GNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYN 3780
GNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYN
Sbjct: 3721 GNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYN 3780
Query: 3781 ITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQY 3840
ITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQY
Sbjct: 3781 ITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQY 3840
Query: 3841 EIRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINY 3900
EIRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINY
Sbjct: 3841 EIRIQACQNGSCGVSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINY 3900
Query: 3901 FIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQT 3960
FIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQT
Sbjct: 3901 FIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQT 3960
Query: 3961 LEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFT 4020
LEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFT
Sbjct: 3961 LEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFT 4020
Query: 4021 VKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENG 4080
VKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENG
Sbjct: 4021 VKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENG 4080
Query: 4081 RALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGC 4140
RALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGC
Sbjct: 4081 RALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGC 4140
Query: 4141 AHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAW 4200
AHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAW
Sbjct: 4141 AHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAW 4200
Query: 4201 GNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQ 4260
GNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQ
Sbjct: 4201 GNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQ 4260
Query: 4261 APPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTD 4320
APPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTD
Sbjct: 4261 APPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTD 4320
Query: 4321 EELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPT 4380
EELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPT
Sbjct: 4321 EELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPT 4380
Query: 4381 VQNGKITKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTM 4440
VQNGKITKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTM
Sbjct: 4381 VQNGKITKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTM 4440
Query: 4441 EALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLT 4500
EALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLT
Sbjct: 4441 EALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYRDFTLT 4500
Query: 4501 PGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNG 4560
PGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNG
Sbjct: 4501 PGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNG 4560
Query: 4561 DIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASS 4620
DIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASS
Sbjct: 4561 DIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASS 4620
Query: 4621 DWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQ 4680
DWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQ
Sbjct: 4621 DWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQ 4680
Query: 4681 PRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRA 4740
PRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRA
Sbjct: 4681 PRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRA 4740
Query: 4741 PTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTN 4800
PTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTN
Sbjct: 4741 PTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTN 4800
Query: 4801 YSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIH 4860
YSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIH
Sbjct: 4801 YSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIH 4860
Query: 4861 SYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTAS 4920
SYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTAS
Sbjct: 4861 SYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTAS 4920
Query: 4921 EWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDTT 4980
EWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDTT
Sbjct: 4921 EWISFTTQKELPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDTT 4980
Query: 4981 LYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSE 5040
LYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSE
Sbjct: 4981 LYIPRTADKTFFFQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSE 5040
Query: 5041 LWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYPPGENHMG 5100
LWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYPPGENHMG
Sbjct: 5041 LWFIVLMAMLGLILLAIFLSLILQRKIHKEPYIRERPPLVPLQKRMSPLNVYPPGENHMG 5100
Query: 5101 LADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQLMDIQDKKVLMDN 5160
LADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQLMDIQDKKVLMDN
Sbjct: 5101 LADTKIPRSGTPVSIRSNRSACVLRIPSQNQTSLTYSQGSLHRSVSQLMDIQDKKVLMDN 5160
Query: 5161 SLWEAIMGHNSGLYVDEEDLMNAIKDFSSVTKERTTFTDTHL 5202
SLWEAIMGHNSGLYVDEEDLMNAIKDFSSVTKERTTFTDTHL
Sbjct: 5161 SLWEAIMGHNSGLYVDEEDLMNAIKDFSSVTKERTTFTDTHL 5202
>gi|219842259 usherin isoform A [Homo sapiens]
Length = 1546
Score = 3284 bits (8515), Expect = 0.0
Identities = 1543/1543 (100%), Positives = 1543/1543 (100%)
Query: 1 MNCPVLSLGSGFLFQVIEMLIFAYFASISLTESRGLFPRLENVGAFKKVSIVPTQAVCGL 60
MNCPVLSLGSGFLFQVIEMLIFAYFASISLTESRGLFPRLENVGAFKKVSIVPTQAVCGL
Sbjct: 1 MNCPVLSLGSGFLFQVIEMLIFAYFASISLTESRGLFPRLENVGAFKKVSIVPTQAVCGL 60
Query: 61 PDRSTFCHSSAAAESIQFCTQRFCIQDCPYRSSHPTYTALFSAGLSSCITPDKNDLHPNA 120
PDRSTFCHSSAAAESIQFCTQRFCIQDCPYRSSHPTYTALFSAGLSSCITPDKNDLHPNA
Sbjct: 61 PDRSTFCHSSAAAESIQFCTQRFCIQDCPYRSSHPTYTALFSAGLSSCITPDKNDLHPNA 120
Query: 121 HSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQGVMCVIEKTVDGQIVFKLTIS 180
HSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQGVMCVIEKTVDGQIVFKLTIS
Sbjct: 121 HSNSASFIFGNHKSCFSSPPSPKLMASFTLAVWLKPEQQGVMCVIEKTVDGQIVFKLTIS 180
Query: 181 EKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTPFNAR 240
EKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTPFNAR
Sbjct: 181 EKETMFYYRTVNGLQPPIKVMTLGRILVKKWIHLSVQVHQTKISFFINGVEKDHTPFNAR 240
Query: 241 TLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQS 300
TLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQS
Sbjct: 241 TLSGSITDFASGTVQIGQSLNGLEQFVGRMQDFRLYQVALTNREILEVFSGDLLRLHAQS 300
Query: 301 HCRCPGSHPRVHPLAQRYCIPNDAGDTADNRVSRLNPEAHPLSFVNDNDVGTSWVSNVFT 360
HCRCPGSHPRVHPLAQRYCIPNDAGDTADNRVSRLNPEAHPLSFVNDNDVGTSWVSNVFT
Sbjct: 301 HCRCPGSHPRVHPLAQRYCIPNDAGDTADNRVSRLNPEAHPLSFVNDNDVGTSWVSNVFT 360
Query: 361 NITQLNQGVTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNCG 420
NITQLNQGVTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNCG
Sbjct: 361 NITQLNQGVTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNCG 420
Query: 421 AFGMKNNGDLEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFV 480
AFGMKNNGDLEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFV
Sbjct: 421 AFGMKNNGDLEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFV 480
Query: 481 KATQIRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQ 540
KATQIRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQ
Sbjct: 481 KATQIRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQ 540
Query: 541 ESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRG 600
ESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRG
Sbjct: 541 ESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRG 600
Query: 601 GGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG 660
GGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG
Sbjct: 601 GGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG 660
Query: 661 QCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKAN 720
QCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKAN
Sbjct: 661 QCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKAN 720
Query: 721 VIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTC 780
VIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTC
Sbjct: 721 VIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTC 780
Query: 781 RENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNN 840
RENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNN
Sbjct: 781 RENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNN 840
Query: 841 SFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMC 900
SFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMC
Sbjct: 841 SFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMC 900
Query: 901 ECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVN 960
ECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVN
Sbjct: 901 ECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVN 960
Query: 961 HICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQ 1020
HICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQ
Sbjct: 961 HICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQ 1020
Query: 1021 CFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSP 1080
CFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSP
Sbjct: 1021 CFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSP 1080
Query: 1081 NAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVT 1140
NAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVT
Sbjct: 1081 NAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVT 1140
Query: 1141 YKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEG 1200
YKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEG
Sbjct: 1141 YKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEG 1200
Query: 1201 HETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELH 1260
HETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELH
Sbjct: 1201 HETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELH 1260
Query: 1261 VEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPP 1320
VEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPP
Sbjct: 1261 VEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPP 1320
Query: 1321 QTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNI 1380
QTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNI
Sbjct: 1321 QTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNI 1380
Query: 1381 SWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIY 1440
SWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIY
Sbjct: 1381 SWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIY 1440
Query: 1441 EFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIY 1500
EFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIY
Sbjct: 1441 EFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIY 1500
Query: 1501 QLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDFTG 1543
QLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDFTG
Sbjct: 1501 QLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDFTG 1543
Score = 155 bits (391), Expect = 1e-36
Identities = 126/469 (26%), Positives = 202/469 (43%), Gaps = 68/469 (14%)
Query: 4155 PDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFT 4214
P Q P S+++ LSWS P +PN + Y ++R FE I T
Sbjct: 1054 PFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFE--------------IYTT 1099
Query: 4215 EYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYV 4274
E + + DT L P+T+ Y I T N G T S +T PEG +SY+
Sbjct: 1100 EDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNL--TLSYI 1157
Query: 4275 -SMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYP---FSFDPVTFNYTDEELLPFSTYS 4330
+ + ++W +G I+ Y L + S++ + T L+PF+ Y
Sbjct: 1158 IPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYD 1217
Query: 4331 YALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKY- 4389
+++QACTSGGC S P ++TT +A P +SPP + +S+T+++V WSPP NG I +Y
Sbjct: 1218 FSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYE 1277
Query: 4390 ------------------------------LVRYDNKESLAGQGLCLLVSHLQPYSQYNF 4419
V N+ +L ++ L+PY++Y F
Sbjct: 1278 LYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEF 1337
Query: 4420 SLVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRN--PNGQIRSY 4477
++A G +S S T E+ P M P++ S S+ I+W+ P + G++ Y
Sbjct: 1338 RVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGY 1397
Query: 4478 EL--------RRDGTIVYTGL-------ETRYRDFTLTPGVEYSYTVTASNSQGGILSPL 4522
++ ++ + ++ L E Y L P Y +T+T NS G + S
Sbjct: 1398 DINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSAS 1457
Query: 4523 VKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRE 4571
+T +AP+ + PP ++ I + W PP NG Y L RE
Sbjct: 1458 GAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLERRE 1506
Score = 154 bits (390), Expect = 2e-36
Identities = 132/452 (29%), Positives = 200/452 (44%), Gaps = 46/452 (10%)
Query: 3688 PRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEE----QNFTDKNLEPNS 3743
PR + +S+ + L WS P+ PN Y L R+G ++ + Q F D +L P +
Sbjct: 1060 PRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYT 1119
Query: 3744 RYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEI 3803
+Y+Y +E GS+ S +T PE I IG S+ + W +
Sbjct: 1120 KYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTT--LSNQSG 1177
Query: 3804 PVEYNVLLNDGSVTPLAFSV------GHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSR 3857
P+E +L S PLA GH S + NL PF +Y+ +QAC +G C S
Sbjct: 1178 PIEKYIL----SCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHSLP 1233
Query: 3858 MFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRR-----PAGIEEE 3912
+ V T +A P L+ P ++ + S + ++W PP + NGIII Y +Y R EE
Sbjct: 1234 ITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEE 1293
Query: 3913 SVLFV---W----------SEGAL---EFMDEGDTLRPFTLYEYRVRACNSKGSVESLWS 3956
S +F W +E AL + M L P+T YE+RV A N GSV S W
Sbjct: 1294 SRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWV 1353
Query: 3957 LTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPES--PNGIISHY--RVVYQERPDD--PT 4010
+T E+ P P S++S+ ++W KP G + Y ++ ++ P P
Sbjct: 1354 SERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPM 1413
Query: 4011 FNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLR 4070
S +H T K + GL+P+ Y + N G + S QTL ++P+ LR
Sbjct: 1414 AFSQLLH--TAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLR 1471
Query: 4071 NFIVEQKENGRALLLQWSEPMRTNGVIKTYNI 4102
+V + N + L+W P NG Y +
Sbjct: 1472 PPLV-KGINSTTIHLKWFPPEELNGPSPIYQL 1502
Score = 150 bits (379), Expect = 3e-35
Identities = 117/455 (25%), Positives = 190/455 (41%), Gaps = 48/455 (10%)
Query: 3965 PQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGT 4024
P P P Q S+ ++ L+W+ P+SPN +H+ R + + + ++++
Sbjct: 1054 PFQQPPPRGQVQSSSAINLSWSPPDSPN---AHWLTYSLLRDGFEIYTTEDQYPYSIQYF 1110
Query: 4025 SHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRALL 4084
L P+T Y + N G S +T P G ++
Sbjct: 1111 LDT----DLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVT 1166
Query: 4085 LQWSEPMRTNGVIKTYNIF------SDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRA 4138
L W+ +G I+ Y + + Y G L PF Y +++ACT
Sbjct: 1167 LTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSG 1226
Query: 4139 GCAHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGK 4198
GC HS P + T +APP P + + ST + + WS P NG IIRYE+ R +
Sbjct: 1227 GCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMR----R 1282
Query: 4199 AWGNQTIQADEKIVF---------------TEYNTERNTFMYNDTGLQPWTQCEYKIYTW 4243
+ ++E VF E + M TGL+P+T+ E+++
Sbjct: 1283 LRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAV 1342
Query: 4244 NSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQ--SNGIIQSYRL- 4300
N AG S+W RT ++ P + PP S ++ L ISW P + G + Y +
Sbjct: 1343 NMAGSVSSAWVSERTGESAPVFMIPP--SVFPLSSYSLNISWEKPADNVTRGKVVGYDIN 1400
Query: 4301 ----QRNEMLYPFSFDPV-------TFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSI 4349
Q + P +F + +YT E L P+ Y + + C S GC TS +
Sbjct: 1401 MLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAG 1460
Query: 4350 TTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNG 4384
TL AAP+++ PP + +++T +++ W PP NG
Sbjct: 1461 QTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNG 1495
Score = 149 bits (375), Expect = 9e-35
Identities = 125/470 (26%), Positives = 199/470 (42%), Gaps = 73/470 (15%)
Query: 4260 QAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRN-------EMLYPFSFD 4312
Q PP G V S ++N +SW PP+ N +Y L R+ E YP+S
Sbjct: 1057 QPPPRG---QVQSSSAIN-----LSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQ 1108
Query: 4313 PVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSITTLEAAPS-EVSPPDLWAVSATQ 4371
+ D +LLP++ YSY ++ G + S + T P ++ + + +
Sbjct: 1109 ----YFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDS 1164
Query: 4372 MNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCL---------LVSHLQPYSQYNFSLV 4422
+ + W+ + Q+G I KY++ + LAG C+ + +L P+++Y+FS+
Sbjct: 1165 VTLTWTTLSNQSGPIEKYIL---SCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQ 1221
Query: 4423 ACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYEL--- 4479
ACT+GGC S+ + T +A P+ + P +Q S + + W PP NG I YEL
Sbjct: 1222 ACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMR 1281
Query: 4480 RRDGTIVYTGLETRYRDFT----------------------------LTPGVEYSYTVTA 4511
R T T E+R + L P +Y + V A
Sbjct: 1282 RLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLA 1341
Query: 4512 SNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVR--TNGDIINY--TL 4567
N G + S V +RT SAP M PP + + ++W+ P T G ++ Y +
Sbjct: 1342 VNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINM 1401
Query: 4568 FIRELFERETKIIHINTTHNSFGMQ-SYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQ 4626
+ ++ + H + + SY V LKP+ YE I C ++GC +S Q
Sbjct: 1402 LSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQ 1461
Query: 4627 TPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQ 4676
T AP PP + G T+ L W P + NG Y+L RR+
Sbjct: 1462 TLAAAPAQLRPP-----LVKGINSTTIHLKWFPPEELNGPSPIYQLERRE 1506
Score = 147 bits (370), Expect = 4e-34
Identities = 121/463 (26%), Positives = 192/463 (41%), Gaps = 60/463 (12%)
Query: 2245 PAPKAHSYSPDSFNVSWTEPEYPNGVITSYGLYLDGILIHNSSE-LSYRAYGFA-----P 2298
P P+ S + N+SW+ P+ PN +Y L DG I+ + + Y F P
Sbjct: 1058 PPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLP 1117
Query: 2299 WSLHSFRVQACTAKGCALGPLVENRTLEAPPEGTVNV-FVKTQGSRKAHVRWEAPFRPNG 2357
++ +S+ ++ G V +T PEG + + ++ GS + W +G
Sbjct: 1118 YTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSG 1177
Query: 2358 LLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNS 2417
+ +L P+ V Y G ET+ I LVPF Y V S
Sbjct: 1178 PIEKYILSCA-----PLAGGQPC-----VSYEGHETS--ATIWNLVPFAKYDFSVQACTS 1225
Query: 2418 QGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGD 2477
G L + PIT+ P + PP++ + T L V WS PA N RY+L MR
Sbjct: 1226 GGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGI-IIRYELYMRRLR 1284
Query: 2478 ST-------------------HGFLELFSN----PSASLSYEVSDLQPYTEYMFRLVASN 2514
ST H F+E + P +++ ++ L+PYT+Y FR++A N
Sbjct: 1285 STKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMT-TITGLEPYTKYEFRVLAVN 1343
Query: 2515 GFGSAHSSWIPFMTAEDKPGPVVPPILLDVKSRMMLVTWQHP--RKSNGVITHYNIYL-- 2570
GS S+W+ T E P ++PP + + S + ++W+ P + G + Y+I +
Sbjct: 1344 MAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLS 1403
Query: 2571 -----------HGRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWT 2619
+L + TV L PY Y+F + C S GC ++ S T
Sbjct: 1404 EQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGC-VTSASGAGQT 1462
Query: 2620 LPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERR 2662
L AP + P + T++ + W PP NG + +ERR
Sbjct: 1463 LAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLERR 1505
Score = 146 bits (368), Expect = 6e-34
Identities = 122/463 (26%), Positives = 204/463 (44%), Gaps = 49/463 (10%)
Query: 2440 PPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSD 2499
PPR + +++ + WS P NA Y L +R G + + + P + + +D
Sbjct: 1059 PPRGQVQSSSAINLSWSPPDSPNAHWLT-YSL-LRDGFEIYTTEDQY--PYSIQYFLDTD 1114
Query: 2500 LQPYTEYMFRLVASNGFGSAHSSWIPFMTAEDKP-GPVVPPILLDVKSRMMLVTWQHPRK 2558
L PYT+Y + + +N GS S + + T P G + ++ + S + +TW
Sbjct: 1115 LLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSN 1174
Query: 2559 SNGVITHYNI----YLHGRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPES 2614
+G I Y + G+ + G+ T+ T+ +L P+ Y F V+ACTS GC L
Sbjct: 1175 QSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGC-LHSLP 1233
Query: 2615 QTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIE-RRVKGKEEVTT-- 2671
TV T P+ + P++ + T + + W PP NG++ + + RR++ +E T+
Sbjct: 1234 ITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEE 1293
Query: 2672 --------------LVTLPRSHSMR---FIDKTSALSPWTKYEYRVLMSTLHGGTNSSAW 2714
V ++++ + + L P+TKYE+RVL + G SSAW
Sbjct: 1294 SRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGSV-SSAW 1352
Query: 2715 VEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPL--IQNGDILSYEIHM-----PDPHIT 2767
V T S P + PP V L ++ ++W+ P + G ++ Y+I+M P I
Sbjct: 1353 VSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIP 1412
Query: 2768 LT------NVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVP 2821
+ S LS V L P+ Y TI C+ GC S T P
Sbjct: 1413 MAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSV-----GCVTSASGAGQTLAAAP 1467
Query: 2822 QNVGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQP 2864
+ P V ++ + + + W PP + NGP+ Y+L RR+ P
Sbjct: 1468 AQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLERRESSLP 1510
Score = 138 bits (348), Expect = 1e-31
Identities = 123/468 (26%), Positives = 193/468 (41%), Gaps = 64/468 (13%)
Query: 4444 PENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRRDGTIVYTGLETRYR-------D 4496
P P QV S +I ++W PP +PN +Y L RDG +YT E +Y D
Sbjct: 1054 PFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYT-TEDQYPYSIQYFLD 1112
Query: 4497 FTLTPGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSG-MEPPKLQARGPQEILVNWDPP 4555
L P +YSY + +N G S V +T P P G + + G + + W
Sbjct: 1113 TDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTL 1172
Query: 4556 VRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTL 4615
+G I Y L L + + + H + S + L PF +Y+ +QACT+
Sbjct: 1173 SNQSGPIEKYILSCAPLAGGQPCVSYEG--HET----SATIWNLVPFAKYDFSVQACTSG 1226
Query: 4616 GCASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRR 4675
GC S + T + P PP ++ + + + W+ P + NG ++ YELY R
Sbjct: 1227 GCLHSLPITVTTAQAPPQRLSPPKMQKISST-----ELHVEWSPPAELNGIIIRYELYMR 1281
Query: 4676 QI-ATQPRKSNPVLIYNGSST----SFIDSE----------------LLPFTEYEYQVWA 4714
++ +T+ S ++ S SF++S L P+T+YE++V A
Sbjct: 1282 RLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLA 1341
Query: 4715 VNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAP------GKPNGI---- 4764
VN AG S+W RTG + P + P+ +SS ++ P GK G
Sbjct: 1342 VNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINM 1401
Query: 4765 -------VSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKG 4817
S+ FS H A++ T+ GL+ + Y + C C +
Sbjct: 1402 LSEQSPQQSIPMAFSQLLHTAKS-----QELSYTVEGLKPYRIYEFTITLCNSVGCVTSA 1456
Query: 4818 PTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQ 4865
A +T A P+ L P + + S T +W PP NG Y+L+
Sbjct: 1457 SGAG-QTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLE 1503
Score = 137 bits (346), Expect = 2e-31
Identities = 121/456 (26%), Positives = 198/456 (43%), Gaps = 54/456 (11%)
Query: 3504 PPTWTKIDNLEDTIVLNWRKPIQSNGPIIYYILLRNGIERFRGT-----SLSFSDKEGIQ 3558
PP ++ + I L+W P N + Y LLR+G E + S+ + +
Sbjct: 1058 PPPRGQVQS-SSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLL 1116
Query: 3559 PFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPS-ITALSAVALHLSWSVPEKSN 3617
P+ +YSY ++ V G S V T GVPE L S I + + ++ L+W+ +
Sbjct: 1117 PYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQS 1176
Query: 3618 GVIKEYQIRQV----GKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFL 3673
G I++Y + G+ + + + T+ L P+ Y F++ ACTS GC S P
Sbjct: 1177 GPIEKYILSCAPLAGGQPCVSYEGHE-TSATIWNLVPFAKYDFSVQACTSGGCLHSLPIT 1235
Query: 3674 GQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQL------------SRNG 3721
T QA P+ + P+ I+ST + + WS P + NG++ +Y+L S
Sbjct: 1236 VTTAQAPPQRL-SPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEES 1294
Query: 3722 NLLFLGG---------SEEQN--------FTDKNLEPNSRYTYKLEVKTGGGSSASDDYI 3764
+ G S +N T LEP ++Y +++ GS +S
Sbjct: 1295 RVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVS 1354
Query: 3765 VQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPE---IPVEYNVLLNDG--SVTPL 3819
+T S P + PP ++ + YS+ ++W P + + + N+L P+
Sbjct: 1355 ERTGESAPVFMIPP-SVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPM 1413
Query: 3820 AFSVGHHQ------STLLENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPMDLNSP 3873
AFS H S +E L P+ YE I C + C S+ +T AAP L P
Sbjct: 1414 AFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPP 1473
Query: 3874 VLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGI 3909
++K + S I +KW PPE+ NG Y + RR + +
Sbjct: 1474 LVKGINSTTIHLKWFPPEELNGPSPIYQLERRESSL 1509
Score = 136 bits (343), Expect = 5e-31
Identities = 122/456 (26%), Positives = 196/456 (42%), Gaps = 48/456 (10%)
Query: 4356 PSEVSPPDLWAVSATQMNVCWSPPTVQNGK-ITKYLVR-----YDNKESLAGQGLCLLVS 4409
P + PP S++ +N+ WSPP N +T L+R Y ++ L +
Sbjct: 1054 PFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDT 1113
Query: 4410 HLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPE-NMDSPTLQVTGSESIEITWKPPR 4468
L PY++Y++ + G T SV+ + T +PE N+ + GS+S+ +TW
Sbjct: 1114 DLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLS 1173
Query: 4469 NPNGQIRSYELR------RDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQGGILSPL 4522
N +G I Y L + Y G ET + L P +Y ++V A S G + S
Sbjct: 1174 NQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHSLP 1233
Query: 4523 VKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHI 4582
+ T+ + P + PPK+Q E+ V W PP NG II Y L++R L +
Sbjct: 1234 ITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEE 1293
Query: 4583 NTTHNSFGMQS-------------------YIVNQLKPFHRYEIRIQACTTLGCASSDWT 4623
+ S G S + L+P+ +YE R+ A G SS W
Sbjct: 1294 SRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWV 1353
Query: 4624 FIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQ--PNGKVLYYELYRRQIATQ- 4680
+T E AP+ PP + + ++++ W P GKV+ Y++ ++ Q
Sbjct: 1354 SERTGESAPVFMIPPSVFPLSS-----YSLNISWEKPADNVTRGKVVGYDI--NMLSEQS 1406
Query: 4681 PRKSNPV----LIYNGSS--TSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAP 4734
P++S P+ L++ S S+ L P+ YE+ + NS G S+ +T A
Sbjct: 1407 PQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAA 1466
Query: 4735 PEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRL 4770
P LR P I+ST + P + NG +Y+L
Sbjct: 1467 PAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQL 1502
Score = 136 bits (343), Expect = 5e-31
Identities = 123/458 (26%), Positives = 188/458 (41%), Gaps = 68/458 (14%)
Query: 4076 QKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQ------FLFRRLDPFTLYT 4129
Q ++ A+ L WS P N TY++ DGF Y+ ++ FL L P+T Y+
Sbjct: 1063 QVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYS 1122
Query: 4130 LTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPT-VHSVKSTSVELSWSEPVNPNGKIIRY 4188
+E G S T P+ L + + + S SV L+W+ N +G I +Y
Sbjct: 1123 YYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKY 1182
Query: 4189 EVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGH 4248
I C G Q + E E + ++N L P+ + ++ + S G
Sbjct: 1183 --ILSC--APLAGGQPCVSYE-------GHETSATIWN---LVPFAKYDFSVQACTSGGC 1228
Query: 4249 TCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRL-------- 4300
S V T QAPP+ LSPP + +S +L + W PP + NGII Y L
Sbjct: 1229 LHSLPITVTTAQAPPQRLSPPKMQKISST--ELHVEWSPPAELNGIIIRYELYMRRLRST 1286
Query: 4301 -----------QRNEMLYPFSF---------DPVTFNYTDEELLPFSTYSYALQACTSGG 4340
Q + L P SF P T L P++ Y + + A G
Sbjct: 1287 KETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG 1346
Query: 4341 CSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPT--VQNGKITKYLVRYDNKES 4398
+S S T E+AP + PP ++ +S+ +N+ W P V GK+ Y + +++S
Sbjct: 1347 SVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQS 1406
Query: 4399 ---------------LAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEAL 4443
Q L V L+PY Y F++ C + GC S S + T+ A
Sbjct: 1407 PQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAA 1466
Query: 4444 PENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELRR 4481
P + P ++ S +I + W PP NG Y+L R
Sbjct: 1467 PAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLER 1504
Score = 135 bits (341), Expect = 8e-31
Identities = 125/480 (26%), Positives = 198/480 (41%), Gaps = 57/480 (11%)
Query: 2607 GCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGK 2666
GCS +P Q P P + +++ +SW PP PN +++ R G
Sbjct: 1049 GCSKTPFQQ------------PPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLR--DGF 1094
Query: 2667 EEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAG 2726
E TT P +S+++ T L P+TKY Y + + +HG T S A V T+P P G
Sbjct: 1095 EIYTTEDQYP--YSIQYFLDTDLL-PYTKYSYYIETTNVHGSTRSVA-VTYKTKPGVPEG 1150
Query: 2727 -VQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMP-----DPHITLTNVTSAVLSQKV 2780
+ + + D+V +TW Q+G I Y + P ++ + S +
Sbjct: 1151 NLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHET---SATI 1207
Query: 2781 THLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVIS 2840
+L+PF Y ++ AC+ G GC SLP VTT PQ + P + +S + + +
Sbjct: 1208 WNLVPFAKYDFSVQACTSG-----GCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVE 1262
Query: 2841 WQPPSKPNGPNLRYELLRRKIQQPLASNPPE----DLNRW-----------HNIYSGTQW 2885
W PP++ NG +RYEL R+++ + E + W N Q
Sbjct: 1263 WSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQT 1322
Query: 2886 LYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTAIDVRW 2945
+ GL +T YE+ + N G S V+ T P + L+ ++++ W
Sbjct: 1323 MTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISW 1382
Query: 2946 AKPTVQDLQGEVEYYTLFWSSATSNDS------LKILPDVNSHVIGH----LKPNTEYWI 2995
KP +G+V Y + S S ++L S + + LKP Y
Sbjct: 1383 EKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEF 1442
Query: 2996 FISVFNGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSI 3055
I++ N V + SA T P + PP V INST + + W P NG Y +
Sbjct: 1443 TITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQL 1502
Score = 132 bits (332), Expect = 9e-30
Identities = 118/453 (26%), Positives = 190/453 (41%), Gaps = 48/453 (10%)
Query: 3595 PPSITALSAVALHLSWSVPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTV-----TGLQ 3649
PP S+ A++LSWS P+ N Y + + G + T+ D+ +++ T L
Sbjct: 1059 PPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTE--DQYPYSIQYFLDTDLL 1116
Query: 3650 PYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPN 3709
PYT YS+ + G T S +T PEG I I S +V L W+ +
Sbjct: 1117 PYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQS 1176
Query: 3710 GLVSQYQLS----RNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIV 3765
G + +Y LS G E + T NL P ++Y + ++ T GG S V
Sbjct: 1177 GPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITV 1236
Query: 3766 QTPMSTPEEIYPPYNITVIGPYSIFVAWIPP----GILI-------------PEIPVEYN 3808
T + P+ + PP + I + V W PP GI+I E
Sbjct: 1237 TTAQAPPQRLSPP-KMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESR 1295
Query: 3809 VLLNDGSVTPLAFSVGHHQSTL--------LENLTPFTQYEIRIQACQNGSCGVSSRMFV 3860
V + G ++P +F +++ L + L P+T+YE R+ A S+ +
Sbjct: 1296 VFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSE 1355
Query: 3861 KTPEAAPMDLNSPVLKALGSACIEIKWMPPEK--PNGIIINYFIYRRPAGIEEESVLFVW 3918
+T E+AP+ + P + L S + I W P G ++ Y I ++S+ +
Sbjct: 1356 RTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAF 1415
Query: 3919 SE-------GALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAP 3971
S+ L + EG L+P+ +YE+ + CNS G V S QTL A P P
Sbjct: 1416 SQLLHTAKSQELSYTVEG--LKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPP 1473
Query: 3972 WAQATSAHSVLLNWTKPESPNGIISHYRVVYQE 4004
+ ++ ++ L W PE NG Y++ +E
Sbjct: 1474 LVKGINSTTIHLKWFPPEELNGPSPIYQLERRE 1506
Score = 129 bits (325), Expect = 6e-29
Identities = 95/312 (30%), Positives = 142/312 (45%), Gaps = 53/312 (16%)
Query: 3460 SYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVL 3519
S T NL P+ Y++ + A S G S + T + PQ +SPP KI + E + +
Sbjct: 1204 SATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTE--LHV 1261
Query: 3520 NWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKE------------------------ 3555
W P + NG II Y L + R R T + S++
Sbjct: 1262 EWSPPAELNGIIIRYELY---MRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALK 1318
Query: 3556 ---------GIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVAL 3606
G++P+ +Y +++ A +AG +S+ V T + P ++PPS+ LS+ +L
Sbjct: 1319 PPQTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSL 1378
Query: 3607 HLSWSVPEKS--NGVIKEYQIRQVGKG------------LIHTDTTDRRQHTVTGLQPYT 3652
++SW P + G + Y I + + L+HT + +TV GL+PY
Sbjct: 1379 NISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYR 1438
Query: 3653 NYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLV 3712
Y FT+T C S GC +S GQTL AAP + P INSTT+ L W PE+ NG
Sbjct: 1439 IYEFTITLCNSVGCVTSASGAGQTLAAAPAQL-RPPLVKGINSTTIHLKWFPPEELNGPS 1497
Query: 3713 SQYQLSRNGNLL 3724
YQL R + L
Sbjct: 1498 PIYQLERRESSL 1509
Score = 123 bits (308), Expect = 5e-27
Identities = 120/484 (24%), Positives = 193/484 (39%), Gaps = 61/484 (12%)
Query: 3861 KTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSE 3920
KTP P P + S+ I + W PP+ PN + Y + R I + +S
Sbjct: 1052 KTPFQQP----PPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYS- 1106
Query: 3921 GALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAPPQ-DFPAPWAQATSAH 3979
+++ + D L P+T Y Y + N GS S+ +T P+ + + +
Sbjct: 1107 --IQYFLDTDLL-PYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSD 1163
Query: 3980 SVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTY 4039
SV L WT + +G I Y + P V + +G A ++ L PF Y
Sbjct: 1164 SVTLTWTTLSNQSGPIEKYILSCAPLAG----GQPCV---SYEGHETSATIWNLVPFAKY 1216
Query: 4040 RIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKT 4099
V A G + S + T ++ P L + QK + L ++WS P NG+I
Sbjct: 1217 DFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKM-QKISSTELHVEWSPPAELNGIIIR 1275
Query: 4100 YNIF-------------------SDGFLE----YSGLNRQFL--------FRRLDPFTLY 4128
Y ++ S G+L N L L+P+T Y
Sbjct: 1276 YELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKY 1335
Query: 4129 TLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVN--PNGKII 4186
+ A AG SA T E+ P + P+V + S S+ +SW +P + GK++
Sbjct: 1336 EFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVV 1395
Query: 4187 RYEVIRRCFEGKAWGNQTIQADEKIVFTE--YNTERNTFMYNDTGLQPWTQCEYKIYTWN 4244
Y++ Q+ Q + F++ + + Y GL+P+ E+ I N
Sbjct: 1396 GYDI-------NMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCN 1448
Query: 4245 SAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNE 4304
S G S+ +TL A P L PP++ +N + + W PPE+ NG Y+L+R E
Sbjct: 1449 SVGCVTSASGAGQTLAAAPAQLRPPLVK--GINSTTIHLKWFPPEELNGPSPIYQLERRE 1506
Query: 4305 MLYP 4308
P
Sbjct: 1507 SSLP 1510
Score = 123 bits (308), Expect = 5e-27
Identities = 105/395 (26%), Positives = 166/395 (42%), Gaps = 55/395 (13%)
Query: 3461 YTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLN 3520
+ D +L PY Y Y I N +G S AV +TK VP+G ++ I D++ L
Sbjct: 1110 FLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYI-IPIGSDSVTLT 1168
Query: 3521 WRKPIQSNGPIIYYIL----LRNG--IERFRGTSLSFSDKEGIQPFQEYSYQLKACTVAG 3574
W +GPI YIL L G + G S + + PF +Y + ++ACT G
Sbjct: 1169 WTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETS-ATIWNLVPFAKYDFSVQACTSGG 1227
Query: 3575 CATSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQI--RQVGKGL 3632
C S + T Q P+ + PP + +S+ LH+ WS P + NG+I Y++ R++
Sbjct: 1228 CLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTK 1287
Query: 3633 IHTDTTDR--------------------------RQHTVTGLQPYTNYSFTLTACTSAGC 3666
T R T+TGL+PYT Y F + A AG
Sbjct: 1288 ETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGS 1347
Query: 3667 TSSEPFLGQTLQAAPEGVWVTPRHII-INSTTVELYWSLP--EKPNGLVSQYQLS----- 3718
SS +T ++AP V++ P + ++S ++ + W P G V Y ++
Sbjct: 1348 VSSAWVSERTGESAP--VFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQ 1405
Query: 3719 --------RNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMS 3770
LL S+E ++T + L+P Y + + + G S QT +
Sbjct: 1406 SPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAA 1465
Query: 3771 TPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPV 3805
P ++ PP + I +I + W PP L P+
Sbjct: 1466 APAQLRPPL-VKGINSTTIHLKWFPPEELNGPSPI 1499
Score = 119 bits (297), Expect = 1e-25
Identities = 114/455 (25%), Positives = 182/455 (40%), Gaps = 63/455 (13%)
Query: 2729 PPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQKV--THLIPF 2786
PP V A+ ++W PP N L+Y + I T Q T L+P+
Sbjct: 1059 PPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPY 1118
Query: 2787 TNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLS-VIPLSESYVVISWQPPS 2845
T YS I + + G T S+ T P VP+ LS +IP+ V ++W S
Sbjct: 1119 TKYSYYIETTN-----VHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLS 1173
Query: 2846 KPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVH 2905
+GP +Y L PLA P H S T W L F Y++ +
Sbjct: 1174 NQSGPIEKYILSCA----PLAGGQPCVSYEGHET-SATIW-----NLVPFAKYDFSVQAC 1223
Query: 2906 NSVGFTPSREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLF-- 2963
S G S +TVTT P+R + ++ T + V W+ P +L G + Y L+
Sbjct: 1224 TSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPA--ELNGIIIRYELYMR 1281
Query: 2964 --------------------WSSATS-----NDSLKILPDVNSHVIGHLKPNTEYWIFIS 2998
W S S N++ P + + G L+P T+Y +
Sbjct: 1282 RLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITG-LEPYTKYEFRVL 1340
Query: 2999 VFNGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSN--PNGVVTEYSIY 3056
N S++SA + T + P M+PP V ++S ++ + W P++ G V Y I
Sbjct: 1341 AVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDIN 1400
Query: 3057 VNNK-------------LYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQI 3103
+ ++ L T + S+ + L P+ IY+ + +C CV S
Sbjct: 1401 MLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAG 1460
Query: 3104 TTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNG 3138
T+ P+ + P ++GI S ++ + W P + NG
Sbjct: 1461 QTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNG 1495
Score = 114 bits (286), Expect = 2e-24
Identities = 117/462 (25%), Positives = 177/462 (38%), Gaps = 59/462 (12%)
Query: 3777 PPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDG-----SVTPLAFSVGHHQSTLL 3831
PP V +I ++W PP P LL DG + +S+ + T
Sbjct: 1058 PPPRGQVQSSSAINLSWSPPDS--PNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDT-- 1113
Query: 3832 ENLTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPM-DLNSPVLKALGSACIEIKWMPP 3890
+L P+T+Y I+ S + KT P +L + +GS + + W
Sbjct: 1114 -DLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTL 1172
Query: 3891 EKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGS 3950
+G I Y + P + V + E + + L PF Y++ V+AC S G
Sbjct: 1173 SNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWN----LVPFAKYDFSVQACTSGGC 1228
Query: 3951 VESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQER----- 4005
+ SL T +APPQ P Q S+ + + W+ P NGII Y + Y R
Sbjct: 1229 LHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYEL-YMRRLRSTK 1287
Query: 4006 ----PDDPTFNSP---TVHAFT-------VKGTSHQAHLYGLEPFTTYRIGVVAANHAGE 4051
+ F S + H+F +K + GLEP+T Y V+A N AG
Sbjct: 1288 ETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGS 1347
Query: 4052 ILSPWTLIQTLESSPSGLRNFIVEQKE---NGRALLLQWSEPMR--TNGVIKTYNI---- 4102
+ S W +T ES+P F++ + +L + W +P T G + Y+I
Sbjct: 1348 VSSAWVSERTGESAPV----FMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLS 1403
Query: 4103 -----------FSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTD 4151
FS + L P+ +Y T+ C GC SA T
Sbjct: 1404 EQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTL 1463
Query: 4152 EAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRR 4193
A P P V + ST++ L W P NG Y++ RR
Sbjct: 1464 AAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLERR 1505
Score = 113 bits (283), Expect = 4e-24
Identities = 113/498 (22%), Positives = 193/498 (38%), Gaps = 74/498 (14%)
Query: 2032 LTACTLAGCTESSHALNISTP---QEAPQEVQPPVAKSLPSSLL-LSWNPPKKANGIITQ 2087
+T C S+ L+++ + P + PP + SS + LSW+PP N
Sbjct: 1027 VTGSKCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLT 1086
Query: 2088 YCLYMDGRLIYSGSEEN-YTV-----TDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQL 2141
Y L DG IY+ ++ Y++ TDL +T + + + G T S V T
Sbjct: 1087 YSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPG 1146
Query: 2142 PPE-HVDSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMS------------NHTHDFT 2188
PE ++ + + S ++ + W SG +E+Y+L + H T
Sbjct: 1147 VPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSAT 1206
Query: 2189 IWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPK 2248
IW+++ P KY + ACT GGC S T + P+ + PK
Sbjct: 1207 IWNLV----------------PFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPK 1250
Query: 2249 AHSYSPDSFNVSWTEPEYPNGVITSYGLYL------------DGILIHNSSELSYRAY-- 2294
S +V W+ P NG+I Y LY+ + + +S LS ++
Sbjct: 1251 MQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVE 1310
Query: 2295 -----------------GFAPWSLHSFRVQACTAKGCALGPLVENRTLEAPPEGTVNVFV 2337
G P++ + FRV A G V RT E+ P + V
Sbjct: 1311 SANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSV 1370
Query: 2338 KTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTL-LNVTKVMYSGEETNLW 2396
S ++ WE P + + V+ I + ++ + ++++++ + L
Sbjct: 1371 FPLSSYSLNISWEKP--ADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELS 1428
Query: 2397 VLIDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWS 2456
++GL P+ Y + + NS G + + AP + PP + T++ + W
Sbjct: 1429 YTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWF 1488
Query: 2457 TPARNNAPGSPRYQLQMR 2474
P N P SP YQL+ R
Sbjct: 1489 PPEELNGP-SPIYQLERR 1505
Score = 113 bits (283), Expect = 4e-24
Identities = 116/467 (24%), Positives = 178/467 (38%), Gaps = 50/467 (10%)
Query: 4532 PSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGM 4591
P PP+ Q + I ++W PP N + Y+L +R+ FE I+ + +
Sbjct: 1054 PFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSL-LRDGFE-----IYTTEDQYPYSI 1107
Query: 4592 QSYIVNQLKPFHRYEIRIQACTTLGCASS-DWTFIQTPEIAPLMQPPPHLEVQMAPGGFQ 4650
Q ++ L P+ +Y I+ G S T+ P + P +L +
Sbjct: 1108 QYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGV-----PEGNLTLSYIIPIGS 1162
Query: 4651 PTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEY 4710
+V+L WT +G + Y L +A P + Y G TS L+PF +Y++
Sbjct: 1163 DSVTLTWTTLSNQSGPIEKYILSCAPLAG----GQPCVSYEGHETSATIWNLVPFAKYDF 1218
Query: 4711 QVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRL 4770
V A S G S T APP+ L P ISST+ V S P + NGI+ Y L
Sbjct: 1219 SVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYEL 1278
Query: 4771 FSSSAHGAETVLSEGM--------------------------ATQQTLHGLQAFTNYSIG 4804
+ + SE T T+ GL+ +T Y
Sbjct: 1279 YMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFR 1338
Query: 4805 VEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPM--FPNGVIHSY 4862
V A S +E RT + P + P + L+S + + W P G + Y
Sbjct: 1339 VLAVNMAGSVSSAWVSE-RTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGY 1397
Query: 4863 ELQFHVACPPDSALPCTPSQIETKYTGLGQKAS--LGGLQPYTTYKLRVVAHNEVGSTAS 4920
++ P ++P SQ+ +T Q+ S + GL+PY Y+ + N VG S
Sbjct: 1398 DINMLSEQSPQQSIPMAFSQL--LHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTS 1455
Query: 4921 EWISFTTQKELP-QYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVL 4966
+ T P Q R P N + + + W LNG Y L
Sbjct: 1456 ASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQL 1502
Score = 107 bits (268), Expect = 2e-22
Identities = 106/419 (25%), Positives = 168/419 (40%), Gaps = 54/419 (12%)
Query: 1904 DSILVYQGKEQSVY------EGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSV 1957
D +Y ++Q Y + L P+T+Y Y + ++ GS S +T P+
Sbjct: 1092 DGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGN 1151
Query: 1958 PTPSRVRSLNGYSIEVTWDE-PVVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLT 2016
T S + + S+ +TW G IEKYIL + P S E TS
Sbjct: 1152 LTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSC----APLAGGQPCVSYEGHETS--- 1204
Query: 2017 GILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKSLPSS-LLLSW 2075
+ L+PF Y ++ ACT GC S + ++T Q PQ + PP + + S+ L + W
Sbjct: 1205 ATIWNLVPFAKYDFSVQACTSGGCLHSL-PITVTTAQAPPQRLSPPKMQKISSTELHVEW 1263
Query: 2076 NPPKKANGIITQYCLYM------------DGRLIYS-----------GSEEN-------- 2104
+PP + NGII +Y LYM + R+ S + EN
Sbjct: 1264 SPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTM 1323
Query: 2105 YTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWK 2164
T+T L +T ++F + A G +S+WV T + P + P + L S +++I W+
Sbjct: 1324 TTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWE 1383
Query: 2165 QP--RKISGILERYVLYM-SNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNK----YLIK 2217
+P G + Y + M S + +I + L Y + G K Y
Sbjct: 1384 KPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFT 1443
Query: 2218 LGACTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSYGL 2276
+ C GC S + T P + P + + ++ W PE NG Y L
Sbjct: 1444 ITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQL 1502
Score = 88.2 bits (217), Expect = 2e-16
Identities = 77/307 (25%), Positives = 137/307 (44%), Gaps = 39/307 (12%)
Query: 1902 GNDSILVYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPS 1961
G + Y+G E S L PF +Y + V A GG ++S T A PQ + +P
Sbjct: 1191 GGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRL-SPP 1249
Query: 1962 RVRSLNGYSIEVTWDEPV-VRGVIEKYIL-----KAYSEDSTRPPRMPSASA-----EFV 2010
+++ ++ + V W P + G+I +Y L ++ E ++ R+ +S FV
Sbjct: 1250 KMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFV 1309
Query: 2011 NTSNLTGI--------LTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPP 2062
++N + +TGL P+ Y + A +AG S+ ++ T + AP + PP
Sbjct: 1310 ESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGSVSSAW-VSERTGESAPVFMIPP 1368
Query: 2063 VAKSLPS-SLLLSWNPPKK--ANGIITQYCLYM-------------DGRLIYSGSEE--N 2104
L S SL +SW P G + Y + M +L+++ + +
Sbjct: 1369 SVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELS 1428
Query: 2105 YTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWK 2164
YTV L + ++F ++ C VGC S+ T P + P++ ++S TIH++W
Sbjct: 1429 YTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWF 1488
Query: 2165 QPRKISG 2171
P +++G
Sbjct: 1489 PPEELNG 1495
Score = 75.1 bits (183), Expect = 2e-12
Identities = 51/170 (30%), Positives = 82/170 (48%), Gaps = 17/170 (10%)
Query: 2987 LKPNTEYWIFISVFNGVHSINSAGLHATTCDGEPQGMLPPEVVI-INSTAVRVIWTSPSN 3045
L P T+Y +I N S S + T G P+G L +I I S +V + WT+ SN
Sbjct: 1115 LLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSN 1174
Query: 3046 PNGVVTEYSIY----------VNNKLYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYAC 3095
+G + +Y + V+ + ++T S + +L PF YD V+ CT C
Sbjct: 1175 QSGPIEKYILSCAPLAGGQPCVSYEGHET------SATIWNLVPFAKYDFSVQACTSGGC 1228
Query: 3096 VKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDL 3145
+ S +TT + P + P ++ I+S L ++W P + NGII+ Y+L
Sbjct: 1229 LHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYEL 1278
Score = 49.3 bits (116), Expect = 1e-04
Identities = 32/90 (35%), Positives = 42/90 (46%), Gaps = 2/90 (2%)
Query: 3449 ETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWT 3508
+ +HT SYT LKPY YE+ I+ NS G S + +T P + PP
Sbjct: 1417 QLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVK 1476
Query: 3509 KIDNLEDTIVLNWRKPIQSNGPIIYYILLR 3538
I++ TI L W P + NGP Y L R
Sbjct: 1477 GINS--TTIHLKWFPPEELNGPSPIYQLER 1504
>gi|21264602 laminin alpha 5 [Homo sapiens]
Length = 3695
Score = 394 bits (1011), Expect = e-108
Identities = 247/756 (32%), Positives = 351/756 (46%), Gaps = 85/756 (11%)
Query: 338 EAHPLSFVNDNDVGTS--WVSNVFTNITQLNQGVTISVDLENGQ-YQVFYIIIQFF-SPQ 393
+AHP S D GT W S + + N+ ++V L+ GQ + V Y++I+F SP+
Sbjct: 113 KAHPASNAID---GTERWWQSPPLSRGLEYNE---VNVTLDLGQVFHVAYVLIKFANSPR 166
Query: 394 PTEIRIQRKKENSLDWEDWQYFA---RNC-GAFGMKNNGDLEKPDSVNCL-QLSNFTPYS 448
P ++R + ++ WQ+FA R+C FG + + + D+ C + S P
Sbjct: 167 PDLWVLERSMDFGRTYQPWQFFASSKRDCLERFGPQTLERITRDDAAICTTEYSRIVPLE 226
Query: 449 RGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHF--------HGQYYTTETAV 500
G + S++ N RPG NF +P L+EF KAT +R F H
Sbjct: 227 NGEIVVSLV----NGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKALRDPT 282
Query: 501 NLRHRYYAVDEITISGRCQCHGHADNCDTT--SQPYRCLCSQESFTEGLHCDRCLPLYND 558
R YY++ +I+I GRC CHGHAD CD + P+R C+ + T G CDRC P +N
Sbjct: 283 VTRRYYYSIKDISIGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQ 342
Query: 559 KPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVD----PFPFEHFRGGGGVCDDCEHNTTG 614
+P++ A C+ C C H+ C+Y+ VD + GGGVC DC+H+TTG
Sbjct: 343 QPWKPATANSANECQSCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTG 402
Query: 615 RNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCN 674
NCE C F+R + VC+ C+C++ T C+ + G+C C+ + SG +C+
Sbjct: 403 VNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDG---TCEDLTGRCYCRPNFSGERCD 459
Query: 675 QCQNGFYNLQELDPDGCSP---------------CNCNTSGTVDGDITCHQNSGQCKCKA 719
C GF P S C+C+ +GT G+C CK
Sbjct: 460 VCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKP 519
Query: 720 NVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDT 779
N G C+ C G F GC+PCQC+ G + C+P +GQC C+ +G CD
Sbjct: 520 NFQGTHCELCAPG------FYGPGCQPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDR 573
Query: 780 CRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQN 839
C ++ + C+ C C AG+LP C+ + G+C+C+P G C++C G
Sbjct: 574 CAPGYFHFPL--CQLCGCSPAGTLP-EGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFPN- 628
Query: 840 NSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQM 899
C C CD G ++ LC + G C C+ G TG C +C P F C
Sbjct: 629 ----CQACTCDPRGALD--QLCG-AGGLCRCRPGYTGTACQECSP-----GFHGFPSCVP 676
Query: 900 CECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTG-- 957
C C + G+L CDP SGQC C P G RC+ C PG Y N C SCH G
Sbjct: 677 CHCSAEGSLHAA-CDPRSGQCSCRPRVTGLRCDTCVPGAY----NFPYCEAGSCHPAGLA 731
Query: 958 AVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGR-CQPCNCHLSGALN--ETC 1014
V+ C+C+ A + G CD+CK ++G P C C+C L G L C
Sbjct: 732 PVDPALPEAQVPCMCR-AHVEGPSCDRCKPGFWGLSPSNPEGCTRCSCDLRGTLGGVAEC 790
Query: 1015 HLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050
TGQCFCK V G C +C LD + GC
Sbjct: 791 QPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGC 826
Score = 212 bits (540), Expect = 7e-54
Identities = 136/454 (29%), Positives = 196/454 (43%), Gaps = 55/454 (12%)
Query: 489 FHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADN-CDTTSQPYRCLCSQESFTEGL 547
F Y T ++ + R + +I ++ C G N C + RCLC +G
Sbjct: 468 FPSCYPTPSSSNDTREQVLPAGQI-VNCDCSAAGTQGNACRKDPRVGRCLCKPNF--QGT 524
Query: 548 HCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDD 607
HC+ C P + Y C+PCQC+S + + DP G C
Sbjct: 525 HCELCAPGF-----------YGPGCQPCQCSSPGVA---DDRCDP--------DTGQCR- 561
Query: 608 CEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRH 667
C G C+ C +F +C+ C C GT CD+ G+C C+
Sbjct: 562 CRVGFEGATCDRCAPGYFH--------FPLCQLCGCSPAGTLPEG--CDE-AGRCLCQPE 610
Query: 668 VSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCD 727
+G C++C+ G++ C C C+ G +D C G C+C+ G C
Sbjct: 611 FAGPHCDRCRPGYHGFPN-----CQACTCDPRGALDQ--LCGAG-GLCRCRPGYTGTACQ 662
Query: 728 HCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGL 787
C+ GF S C PC C+ GS++ C+P SGQC C+ GL+CDTC Y
Sbjct: 663 ECSPGFHGFPS-----CVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNF 717
Query: 788 DVTNCKACDCDTAGSLPGTVCNAKTG-QCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLP 846
C+A C AG P + C+C+ +VEG C++C G + L +N C
Sbjct: 718 PY--CEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPSNPEGCTR 775
Query: 847 CNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLG 906
C+CD GT+ G C TGQC CK V G C C+ + L ++ C+ C CD G
Sbjct: 776 CSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGCRSCRCDIGG 835
Query: 907 TLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYI 940
L G C+P +G C C PN QG C++ Y+
Sbjct: 836 AL-GQSCEPRTGVCRCRPNTQGPTCSEPARDHYL 868
Score = 187 bits (474), Expect = 3e-46
Identities = 121/377 (32%), Positives = 173/377 (45%), Gaps = 50/377 (13%)
Query: 536 CLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPF 595
CLC G C C P + +R ++ C PCQC+ HS C
Sbjct: 1831 CLCPASY--RGDSCQECAPGF----YRDVKGLFLGRCVPCQCHGHSDRC----------- 1873
Query: 596 EHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILC 655
G GVC DC+HNT G +CE C+ F DPSA V PC +V + N + C
Sbjct: 1874 ---LPGSGVCVDCQHNTEGAHCERCQAGFVSS-RDDPSAPCVSCPCPL-SVPSNNFAEGC 1928
Query: 656 DQIGG--QCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDI---TCHQ 710
GG QC CK +G C +C GF+ + C PC+C SG D ++ C
Sbjct: 1929 VLRGGRTQCLCKPGYAGASCERCAPGFFGNPLVLGSSCQPCDC--SGNGDPNLLFSDCDP 1986
Query: 711 NSGQCK-CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECK 769
+G C+ C + G RC+ C GF + + C C C G+ + C+PHSG C CK
Sbjct: 1987 LTGACRGCLRHTTGPRCEICAPGF-YGNALLPGNCTRCDCTPCGT--EACDPHSGHCLCK 2043
Query: 770 KEAKGLQCDTCRENFYGLD-VTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNK 828
G +CD C+E +G D C+ C C A G+ C+ ++GQC C+P G QC +
Sbjct: 2044 AGVTGRRCDRCQEGHFGFDGCGGCRPCACGPAAE--GSECHPQSGQCHCRPGTMGPQCRE 2101
Query: 829 CLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQC-EPHRY 887
C G + L + C C C C+ TG+C C G++G RC+ C + H+
Sbjct: 2102 CAPGYWGLPEQG---CRRCQCP-------GGRCDPHTGRCNCPPGLSGERCDTCSQQHQV 2151
Query: 888 NL---TIDNFQHCQMCE 901
+ + + HC++C+
Sbjct: 2152 PVPGGPVGHSIHCEVCD 2168
Score = 174 bits (440), Expect = 3e-42
Identities = 111/324 (34%), Positives = 143/324 (44%), Gaps = 54/324 (16%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577
CQCHGH+D C S C+ Q + TEG HC+RC F + C C C
Sbjct: 1864 CQCHGHSDRCLPGSGV--CVDCQHN-TEGAHCERC-----QAGFVSSRDDPSAPCVSCPC 1915
Query: 578 ------NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGAD 631
N+ ++ C RGG C C+ G +CE C FF +
Sbjct: 1916 PLSVPSNNFAEGCV------------LRGGRTQCL-CKPGYAGASCERCAPGFF----GN 1958
Query: 632 PSAI-DVCKPCDCDTVGTRNGSIL-CDQIGGQCN-CKRHVSGRQCNQCQNGFYNLQELDP 688
P + C+PCDC G N CD + G C C RH +G +C C GFY L P
Sbjct: 1959 PLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEICAPGFYG-NALLP 2017
Query: 689 DGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHC---NFGFKFLRSFNDVGCE 745
C+ C+C GT C +SG C CKA V G RCD C +FGF GC
Sbjct: 2018 GNCTRCDCTPCGTE----ACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCG-----GCR 2068
Query: 746 PCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPG 805
PC C ++ C+P SGQC C+ G QC C ++GL C+ C C PG
Sbjct: 2069 PCACGPAAEGSE-CHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGCRRCQC------PG 2121
Query: 806 TVCNAKTGQCICKPNVEGRQCNKC 829
C+ TG+C C P + G +C+ C
Sbjct: 2122 GRCDPHTGRCNCPPGLSGERCDTC 2145
Score = 167 bits (422), Expect = 3e-40
Identities = 113/344 (32%), Positives = 151/344 (43%), Gaps = 41/344 (11%)
Query: 662 CNCKRHVSGRQCNQCQNGFY-NLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQC-KCKA 719
C C G C +C GFY +++ L C PC C+ G D C SG C C+
Sbjct: 1831 CLCPASYRGDSCQECAPGFYRDVKGLFLGRCVPCQCH--GHSD---RCLPGSGVCVDCQH 1885
Query: 720 NVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKF---CNPHSG--QCECKKEAKG 774
N G C+ C GF R C C C L N F C G QC CK G
Sbjct: 1886 NTEGAHCERCQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCLCKPGYAG 1945
Query: 775 LQCDTCRENFYGLDV---TNCKACDCDTAG--SLPGTVCNAKTGQCI-CKPNVEGRQCNK 828
C+ C F+G + ++C+ CDC G +L + C+ TG C C + G +C
Sbjct: 1946 ASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEI 2005
Query: 829 CLEGNFYLRQNNSFL---CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPH 885
C G FY N+ L C C+C GT C+ +G C CK GVTG RC++C+
Sbjct: 2006 CAPG-FY---GNALLPGNCTRCDCTPCGTE----ACDPHSGHCLCKAGVTGRRCDRCQEG 2057
Query: 886 RYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNA 945
+ D C+ C C G+ C P SGQC C P G +C +C PG++ P
Sbjct: 2058 HFGF--DGCGGCRPCACGPAAE--GSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQ- 2112
Query: 946 TGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHY 989
GC C C C+ TG+C C ++G+RCD C +
Sbjct: 2113 -GCRRCQCP-----GGRCDPHTGRCNCPPG-LSGERCDTCSQQH 2149
Score = 165 bits (417), Expect = 1e-39
Identities = 114/340 (33%), Positives = 150/340 (44%), Gaps = 44/340 (12%)
Query: 715 CKCKANVIGLRCDHCNFGFKFLRSFNDVG------CEPCQCNLHGSVNKFCNPHSGQC-E 767
C C A+ G C C GF + DV C PCQC HG ++ C P SG C +
Sbjct: 1831 CLCPASYRGDSCQECAPGF-----YRDVKGLFLGRCVPCQC--HGHSDR-CLPGSGVCVD 1882
Query: 768 CKKEAKGLQCDTCRENFYGL---DVTNCKACDCDTA----GSLPGTVCNAKTGQCICKPN 820
C+ +G C+ C+ F C +C C + G V QC+CKP
Sbjct: 1883 CQHNTEGAHCERCQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRTQCLCKPG 1942
Query: 821 VEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLL---CNKSTGQCP-CKLGVTG 876
G C +C G F C PC+C G N LL C+ TG C C TG
Sbjct: 1943 YAGASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPN--LLFSDCDPLTGACRGCLRHTTG 2000
Query: 877 LRCNQCEPHRY-NLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQ 935
RC C P Y N + +C C+C GT CDP SG CLC GRRC++CQ
Sbjct: 2001 PRCEICAPGFYGNALLPG--NCTRCDCTPCGT---EACDPHSGHCLCKAGVTGRRCDRCQ 2055
Query: 936 PGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQ 995
G + G GC PC+C A C+ +GQC C+ ++ G +C +C Y+G P+
Sbjct: 2056 EGHFGFDG-CGGCRPCAC-GPAAEGSECHPQSGQCHCRPGTM-GPQCRECAPGYWGL-PE 2111
Query: 996 TGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDAC 1035
G C+ C C C TG+C C ++G +CD C
Sbjct: 2112 QG-CRRCQCP-----GGRCDPHTGRCNCPPGLSGERCDTC 2145
Score = 159 bits (401), Expect = 9e-38
Identities = 99/289 (34%), Positives = 135/289 (46%), Gaps = 32/289 (11%)
Query: 766 CECKKEAKGLQCDTCRENFY----GLDVTNCKACDCDTAGS--LPGTVCNAKTGQCI-CK 818
C C +G C C FY GL + C C C LPG+ G C+ C+
Sbjct: 1831 CLCPASYRGDSCQECAPGFYRDVKGLFLGRCVPCQCHGHSDRCLPGS------GVCVDCQ 1884
Query: 819 PNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTIN----GSLLCNKSTGQCPCKLGV 874
N EG C +C G R + S C+ C C + N G +L T QC CK G
Sbjct: 1885 HNTEGAHCERCQAGFVSSRDDPSAPCVSCPCPLSVPSNNFAEGCVLRGGRT-QCLCKPGY 1943
Query: 875 TGLRCNQCEPHRYNLTIDNFQHCQMCECDSLG--TLPGTICDPISGQCL-CVPNRQGRRC 931
G C +C P + + CQ C+C G L + CDP++G C C+ + G RC
Sbjct: 1944 AGASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRC 2003
Query: 932 NQCQPGFY---ISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDH 988
C PGFY + PGN T C C T C+ +G C+C+ A + G+RCD+C++
Sbjct: 2004 EICAPGFYGNALLPGNCTRCDCTPCGTEA-----CDPHSGHCLCK-AGVTGRRCDRCQEG 2057
Query: 989 YFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
+FGFD G C+PC C + +E CH +GQC C+ G +C C P
Sbjct: 2058 HFGFDG-CGGCRPCACGPAAEGSE-CHPQSGQCHCRPGTMGPQCRECAP 2104
Score = 149 bits (377), Expect = 5e-35
Identities = 82/217 (37%), Positives = 106/217 (48%), Gaps = 28/217 (12%)
Query: 639 KPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNT 698
+PC C VG + C+ GGQC C HV GR C++C G++ C PC+C
Sbjct: 1436 RPCGCHEVGATGPT--CEPFGGQCPCHAHVIGRDCSRCATGYWGFPN-----CRPCDC-- 1486
Query: 699 SGTVDGDITCHQNSGQCKCKANVIGLRCDHCN---FGFKFLRSFNDVGCEPCQCNLHGS- 754
G C + +GQC C I C C FG L VGCE C C+ G
Sbjct: 1487 -----GARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPL-----VGCEECNCSGPGIQ 1536
Query: 755 --VNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKT 812
+ C+ SGQC+C+ G +CDTC F+G C+ CDC AG+ PG VC+ T
Sbjct: 1537 ELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYP--RCRPCDCHEAGTAPG-VCDPLT 1593
Query: 813 GQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNC 849
GQC CK NV+G +C++C G F L N C C C
Sbjct: 1594 GQCYCKENVQGPKCDQCSLGTFSLDAANPKGCTRCFC 1630
Score = 147 bits (372), Expect = 2e-34
Identities = 80/233 (34%), Positives = 102/233 (43%), Gaps = 30/233 (12%)
Query: 729 CNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLD 788
C L F + G PC C+ G+ C P GQC C G C C ++G
Sbjct: 1420 CRNAAASLSLFYNNGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGF- 1478
Query: 789 VTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLP-- 846
NC+ CDC +C+ TGQCIC P C C Q +F C P
Sbjct: 1479 -PNCRPCDCG------ARLCDELTGQCICPPRTIPPDCLLC--------QPQTFGCHPLV 1523
Query: 847 ----CNCDKTGTIN-GSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCE 901
CNC G C+ +GQC C+ VTG RC+ C P + C+ C+
Sbjct: 1524 GCEECNCSGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSP-----GFHGYPRCRPCD 1578
Query: 902 CDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPG-FYISPGNATGCLPCSC 953
C GT PG +CDP++GQC C N QG +C+QC G F + N GC C C
Sbjct: 1579 CHEAGTAPG-VCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGCTRCFC 1630
Score = 137 bits (344), Expect = 4e-31
Identities = 77/231 (33%), Positives = 107/231 (46%), Gaps = 24/231 (10%)
Query: 676 CQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKF 735
C+N +L +G PC C+ G TC GQC C A+VIG C C G+
Sbjct: 1420 CRNAAASLSLFYNNGARPCGCHEVGATGP--TCEPFGGQCPCHAHVIGRDCSRCATGY-- 1475
Query: 736 LRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGL-DVTNCKA 794
+ C PC C + C+ +GQC C C C+ +G + C+
Sbjct: 1476 ---WGFPNCRPCDCGA-----RLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEE 1527
Query: 795 CDCDTAG--SLPGTVCNAKTGQCICKPNVEGRQCNKCLEG-NFYLRQNNSFLCLPCNCDK 851
C+C G L C+ +GQC C+PNV GR+C+ C G + Y R C PC+C +
Sbjct: 1528 CNCSGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPR------CRPCDCHE 1581
Query: 852 TGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCEC 902
GT G +C+ TGQC CK V G +C+QC ++L N + C C C
Sbjct: 1582 AGTAPG--VCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGCTRCFC 1630
Score = 136 bits (342), Expect = 6e-31
Identities = 72/211 (34%), Positives = 104/211 (49%), Gaps = 24/211 (11%)
Query: 846 PCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSL 905
PC C + G + C GQCPC V G C++C + F +C+ C+C +
Sbjct: 1437 PCGCHEVGATGPT--CEPFGGQCPCHAHVIGRDCSRCATGYWG-----FPNCRPCDCGA- 1488
Query: 906 GTLPGTICDPISGQCLCVPNRQGRRCNQCQPG-FYISPGNATGCLPCSCHTTGA---VNH 961
+CD ++GQC+C P C CQP F P GC C+C G +
Sbjct: 1489 -----RLCDELTGQCICPPRTIPPDCLLCQPQTFGCHP--LVGCEECNCSGPGIQELTDP 1541
Query: 962 ICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQC 1021
C++ +GQC C+ ++ G+RCD C + G+ RC+PC+CH +G C +TGQC
Sbjct: 1542 TCDTDSGQCKCRP-NVTGRRCDTCSPGFHGYP----RCRPCDCHEAGTAPGVCDPLTGQC 1596
Query: 1022 FCKQFVTGSKCDACVPSASHLDVNNLLGCSK 1052
+CK+ V G KCD C LD N GC++
Sbjct: 1597 YCKENVQGPKCDQCSLGTFSLDAANPKGCTR 1627
Score = 135 bits (341), Expect = 8e-31
Identities = 81/259 (31%), Positives = 108/259 (41%), Gaps = 36/259 (13%)
Query: 524 ADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKS 583
A+ C +CLC G C+RC P + P G +C+PC C+ +
Sbjct: 1925 AEGCVLRGGRTQCLCKPGY--AGASCERCAPGFFGNPLVLGS-----SCQPCDCSGNGDP 1977
Query: 584 CHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDC 643
DP G C C +TTG CE+C F+ + C CDC
Sbjct: 1978 NLLFSDCDPLT--------GACRGCLRHTTGPRCEICAPGFYGNALLPGN----CTRCDC 2025
Query: 644 DTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVD 703
GT CD G C CK V+GR+C++CQ G + GC PC C G
Sbjct: 2026 TPCGTE----ACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCG--GCRPCAC---GPAA 2076
Query: 704 GDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHS 763
CH SGQC C+ +G +C C G+ L + GC CQC C+PH+
Sbjct: 2077 EGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLP---EQGCRRCQCP-----GGRCDPHT 2128
Query: 764 GQCECKKEAKGLQCDTCRE 782
G+C C G +CDTC +
Sbjct: 2129 GRCNCPPGLSGERCDTCSQ 2147
Score = 130 bits (327), Expect = 3e-29
Identities = 76/229 (33%), Positives = 103/229 (44%), Gaps = 35/229 (15%)
Query: 568 YAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQ 627
Y +PC C+ + + +PF GG C C + GR+C C ++
Sbjct: 1431 YNNGARPCGCHEVGAT---GPTCEPF--------GGQCP-CHAHVIGRDCSRCATGYW-- 1476
Query: 628 VGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELD 687
C+PCDC G+ LCD++ GQC C C CQ + L
Sbjct: 1477 ------GFPNCRPCDC-------GARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLV 1523
Query: 688 PDGCSPCNCNTSGTVD-GDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEP 746
GC CNC+ G + D TC +SGQCKC+ NV G RCD C+ GF C P
Sbjct: 1524 --GCEECNCSGPGIQELTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPR-----CRP 1576
Query: 747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKAC 795
C C+ G+ C+P +GQC CK+ +G +CD C + LD N K C
Sbjct: 1577 CDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGC 1625
Score = 123 bits (309), Expect = 4e-27
Identities = 89/329 (27%), Positives = 129/329 (39%), Gaps = 62/329 (18%)
Query: 747 CQCNLHGSV---NKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSL 803
C C+ H +P QC C+ G CD C F + K ++A
Sbjct: 300 CVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGF---NQQPWKPATANSANEC 356
Query: 804 PGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNK 863
C C P V+ R+ ++ L+G T G +C
Sbjct: 357 QSCNCYGHATDCYYDPEVDRRRASQSLDG---------------------TYQGGGVC-- 393
Query: 864 STGQCPCKLGVTGLRCNQCEPHRY---NLTIDNFQHCQMCECDSLGTLPGTICDPISGQC 920
C+ TG+ C +C P Y N +D+ C+ C C+S T GT C+ ++G+C
Sbjct: 394 ----IDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFT-DGT-CEDLTGRC 447
Query: 921 LCVPNRQGRRCNQCQPGF------YISPGNATGC----LP------CSCHTTGAVNHICN 964
C PN G RC+ C GF Y +P ++ LP C C G + C
Sbjct: 448 YCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACR 507
Query: 965 S--LTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCF 1022
G+C+C+ + G C+ C ++G CQPC C G ++ C TGQC
Sbjct: 508 KDPRVGRCLCKP-NFQGTHCELCAPGFYG-----PGCQPCQCSSPGVADDRCDPDTGQCR 561
Query: 1023 CKQFVTGSKCDACVPSASHLDVNNLLGCS 1051
C+ G+ CD C P H + L GCS
Sbjct: 562 CRVGFEGATCDRCAPGYFHFPLCQLCGCS 590
Score = 83.2 bits (204), Expect = 6e-15
Identities = 59/218 (27%), Positives = 79/218 (36%), Gaps = 64/218 (29%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577
C CH T +P+ C + G C RC Y P NC+PC C
Sbjct: 1438 CGCH-EVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFP----------NCRPCDC 1486
Query: 578 NSH--------------------------SKSCHYNISVDPFPFEHFRGGGGV------- 604
+ + CH + + E G G+
Sbjct: 1487 GARLCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCE----ECNCSGPGIQELTDPT 1542
Query: 605 CDD------CEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQI 658
CD C N TGR C+ C F C+PCDC GT G +CD +
Sbjct: 1543 CDTDSGQCKCRPNVTGRRCDTCSPGFH--------GYPRCRPCDCHEAGTAPG--VCDPL 1592
Query: 659 GGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNC 696
GQC CK +V G +C+QC G ++L +P GC+ C C
Sbjct: 1593 TGQCYCKENVQGPKCDQCSLGTFSLDAANPKGCTRCFC 1630
Score = 68.6 bits (166), Expect = 2e-10
Identities = 41/132 (31%), Positives = 56/132 (42%), Gaps = 28/132 (21%)
Query: 937 GFYISPGNAT----------------GCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQ 980
G++ISP +++ G PC CH GA C GQC C A + G+
Sbjct: 1408 GYHISPSSSSLFCRNAAASLSLFYNNGARPCGCHEVGATGPTCEPFGGQCPCH-AHVIGR 1466
Query: 981 RCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSAS 1040
C +C Y+GF C+PC+C GA C +TGQC C C C P
Sbjct: 1467 DCSRCATGYWGFP----NCRPCDC---GA--RLCDELTGQCICPPRTIPPDCLLCQPQT- 1516
Query: 1041 HLDVNNLLGCSK 1052
+ L+GC +
Sbjct: 1517 -FGCHPLVGCEE 1527
Score = 37.0 bits (84), Expect = 0.51
Identities = 32/159 (20%), Positives = 64/159 (40%), Gaps = 18/159 (11%)
Query: 1740 ISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGK 1799
+ + R + GL+ + P +L +++ + R + + C+G+
Sbjct: 3545 LELEVRPLAVTGLIFHLGQARTPPYLQLQVTEKQVLLRADDGAGEFSTSVTRPSVLCDGQ 3604
Query: 1800 WNKVIIKKEGSFISASVNGLMKH------ASESGDQPLVVNSPVYVGGIPQELLNSYQHL 1853
W+++ + K G+ + V+ H A+ +G +P+Y+GG+P+ +
Sbjct: 3605 WHRLAVMKSGNVLRLEVDAQSNHTVGPLLAAAAG-----APAPLYLGGLPEPMAVQ---- 3655
Query: 1854 CLEQGFGGCMKDVKFTRGAVVNLASVS-SGAVRVNLDGC 1891
+ GCM+ + R V SV GA V GC
Sbjct: 3656 PWPPAYCGCMRRLAVNRSPVAMTRSVEVHGA--VGASGC 3692
>gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens]
Length = 3333
Score = 325 bits (833), Expect = 7e-88
Identities = 201/637 (31%), Positives = 297/637 (46%), Gaps = 61/637 (9%)
Query: 338 EAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTISVDLENGQ-YQVFYIIIQFF-SPQPT 395
+AHP++ D W S ++ TQ N+ +++ L+ GQ + V YI+I+F SP+P
Sbjct: 112 KAHPVTNAIDGSERW-WQSPPLSSGTQYNR---VNLTLDLGQLFHVAYILIKFANSPRPD 167
Query: 396 EIRIQRKKENSLDWEDWQYFARN----CGAFGMKNNGDLEKPDSVNCL-QLSNFTPYSRG 450
++R + + WQYFA + FG + N + + D V C+ + S P G
Sbjct: 168 LWVLERSVDFGSTYSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENG 227
Query: 451 NVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHF--------HGQYYTTETAVNL 502
V S++ N RPG NF + +L+EF KAT IR F H
Sbjct: 228 EVVVSLI----NGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQRDPTVT 283
Query: 503 RHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFR 562
R YY++ +I+I G+C C+GHA+ C+ + C + T G CDRC YN + +R
Sbjct: 284 RRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWR 343
Query: 563 QGDQVYAFNCKPCQCNSHSKSCHYNISVD----PFPFEHFRGGGGVCDDCEHNTTGRNCE 618
+ C+ C C+ H+ +C+Y+ V+ + GGGVC +C+HNT G NCE
Sbjct: 344 PAAWEQSHECEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCE 403
Query: 619 LCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQN 678
C ++R G A D C PC CD C+Q G+C+CK + G C +C
Sbjct: 404 QCAKGYYRPYGVPVDAPDGCIPCSCDPEHADG----CEQGSGRCHCKPNFHGDNCEKCAI 459
Query: 679 GFYNL--------------QELDP--DGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVI 722
G+YN DP C+CN G + H G+C C+ V
Sbjct: 460 GYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAH---GRCLCRPGVE 516
Query: 723 GLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRE 782
G RCD C GF ++ C+ C C+ GS C+ +GQCEC+ G +CD C
Sbjct: 517 GPRCDTCRSGF-----YSFPICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLS 571
Query: 783 NFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSF 842
Y + CD AG++ N+ G C CK +VEG C++C + L + N
Sbjct: 572 GAYDFPHCQGSSSACDPAGTI-----NSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPS 626
Query: 843 LCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCEC 902
C C C K GT++G+ C + G C CK V G C+ CE + L N+ CQ C+C
Sbjct: 627 GCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQC 686
Query: 903 DSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFY 939
D G L ++C SG C C + G+ C + + +Y
Sbjct: 687 DIGGAL-SSMCSGPSGVCQCREHVVGKVCQRPENNYY 722
Score = 160 bits (404), Expect = 4e-38
Identities = 85/239 (35%), Positives = 113/239 (47%), Gaps = 21/239 (8%)
Query: 729 CNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLD 788
C + L +F G PC+C+ G+ C+P GQC C+ G QC C YG
Sbjct: 1248 CKNSARSLVAFYHKGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGF- 1306
Query: 789 VTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCN 848
CK C C +C TGQC C P QC C +F C CN
Sbjct: 1307 -PRCKPCSCGR------RLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAG--CEGCN 1357
Query: 849 CDKTGTINGSL-LCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGT 907
C + GTI ++ C++ +GQC CK +TG +C++C Y F C C C+ GT
Sbjct: 1358 CSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFY-----RFPECVPCNCNRDGT 1412
Query: 908 LPGTICDPISGQCLCVPNRQGRRCNQCQPG-FYISPGNATGCLPCSCHTTGAVNHICNS 965
PG +CDP +G CLC N +G CN C+ G F++ P N GC C C VN+ C+S
Sbjct: 1413 EPG-VCDPGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFCF---GVNNQCHS 1467
Score = 159 bits (403), Expect = 5e-38
Identities = 120/421 (28%), Positives = 176/421 (41%), Gaps = 76/421 (18%)
Query: 680 FYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSF 739
+Y+++++ G C CN V +I + +C+C+ + G CD C G+ R
Sbjct: 287 YYSIKDISIGG--QCVCNGHAEVC-NINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWR 343
Query: 740 -----NDVGCEPCQCNLHGSVNKFCNPH----------------SGQC-ECKKEAKGLQC 777
CE C C+ H S N + +P G C C+ G+ C
Sbjct: 344 PAAWEQSHECEACNCHGHAS-NCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNC 402
Query: 778 DTCRENFY---GLDVT---NCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLE 831
+ C + +Y G+ V C C CD + C +G+C CKPN G C KC
Sbjct: 403 EQCAKGYYRPYGVPVDAPDGCIPCSCDPEHA---DGCEQGSGRCHCKPNFHGDNCEKCAI 459
Query: 832 GN----FYLRQNNSFLCLP------------CNCDKTGTINGSLLCNKSTGQCPCKLGVT 875
G F LR + P C+C+ G + +C+ + G+C C+ GV
Sbjct: 460 GYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPE--ICD-AHGRCLCRPGVE 516
Query: 876 GLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQ 935
G RC+ C Y+ I CQ C C +LG+ C ++GQC C P G+RC++C
Sbjct: 517 GPRCDTCRSGFYSFPI-----CQACWCSALGSYQMP-CSSVTGQCECRPGVTGQRCDRCL 570
Query: 936 PGFYISP---GNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGF 992
G Y P G+++ C P NS G C C+ + G C +CK Y+
Sbjct: 571 SGAYDFPHCQGSSSACDPAGT---------INSNLGYCQCK-LHVEGPTCSRCKLLYWNL 620
Query: 993 DPQT-GRCQPCNCHLSGALNET--CHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLG 1049
D + C C CH +G ++ T C G C CK V G CD C L+ +N G
Sbjct: 621 DKENPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFG 680
Query: 1050 C 1050
C
Sbjct: 681 C 681
Score = 153 bits (386), Expect = 5e-36
Identities = 80/216 (37%), Positives = 105/216 (48%), Gaps = 28/216 (12%)
Query: 640 PCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTS 699
PC+C G C GGQC C+ +V GRQC +C G Y C PC+C
Sbjct: 1265 PCECHPTGATGPH--CSPEGGQCPCQPNVIGRQCTRCATGHYGFPR-----CKPCSC--- 1314
Query: 700 GTVDGDITCHQNSGQCKCKANVIGLRCDHC---NFGFKFLRSFNDVGCEPCQCNLHGSVN 756
G C + +GQC+C + +C+ C +F F + GCE C C+ G++
Sbjct: 1315 ----GRRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPM-----AGCEGCNCSRRGTIE 1365
Query: 757 KF---CNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTG 813
C+ SGQC CK G QCD C FY C C+C+ G+ PG VC+ TG
Sbjct: 1366 AAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFP--ECVPCNCNRDGTEPG-VCDPGTG 1422
Query: 814 QCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNC 849
C+CK NVEG +CN C EG+F+L N C C C
Sbjct: 1423 ACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFC 1458
Score = 147 bits (372), Expect = 2e-34
Identities = 75/231 (32%), Positives = 109/231 (47%), Gaps = 24/231 (10%)
Query: 676 CQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFG-FK 734
C+N +L G PC C+ +G C GQC C+ NVIG +C C G +
Sbjct: 1248 CKNSARSLVAFYHKGALPCECHPTGATGPH--CSPEGGQCPCQPNVIGRQCTRCATGHYG 1305
Query: 735 FLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGL-DVTNCK 793
F R C+PC C + C +GQC C QC+ C + + + C+
Sbjct: 1306 FPR------CKPCSCG-----RRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCE 1354
Query: 794 ACDCDTAGSLPGTV--CNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDK 851
C+C G++ + C+ +GQC CKP + GRQC++C G + + C+PCNC++
Sbjct: 1355 GCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFPE-----CVPCNCNR 1409
Query: 852 TGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCEC 902
GT G +C+ TG C CK V G CN C ++L N + C C C
Sbjct: 1410 DGTEPG--VCDPGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFC 1458
Score = 142 bits (358), Expect = 9e-33
Identities = 81/261 (31%), Positives = 114/261 (43%), Gaps = 40/261 (15%)
Query: 535 RCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFP 594
RCLC EG CD C + P Q A C+S + C
Sbjct: 508 RCLCRPG--VEGPRCDTCRSGFYSFPICQACWCSALGSYQMPCSSVTGQC---------- 555
Query: 595 FEHFRGGGGVCDDCEHNTTGRNCELCKD--YFFRQVGADPSAIDVCKPCDCDTVGTRNGS 652
+C TG+ C+ C Y F SA CD GT N +
Sbjct: 556 ------------ECRPGVTGQRCDRCLSGAYDFPHCQGSSSA--------CDPAGTINSN 595
Query: 653 ILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNS 712
+ G C CK HV G C++C+ ++NL + +P GCS C C+ +GTV G C Q
Sbjct: 596 L------GYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTGECRQGD 649
Query: 713 GQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEA 772
G C CK++V G CD C G+ L N GC+ CQC++ G+++ C+ SG C+C++
Sbjct: 650 GDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCREHV 709
Query: 773 KGLQCDTCRENFYGLDVTNCK 793
G C N+Y D+ + K
Sbjct: 710 VGKVCQRPENNYYFPDLHHMK 730
Score = 138 bits (347), Expect = 2e-31
Identities = 107/351 (30%), Positives = 141/351 (40%), Gaps = 64/351 (18%)
Query: 747 CQCNLHGSVNKFCNPHS-GQCECKKEAKGLQCDTCRENFYGL--------DVTNCKACDC 797
C CN H V NP +CEC+ G CD C + C+AC+C
Sbjct: 299 CVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNC 358
Query: 798 D--------------TAGSLPGTVCNAKTGQCI-CKPNVEGRQCNKCLEGNFYLRQNNSF 842
SL A G CI C+ N G C +C +G Y R
Sbjct: 359 HGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKG--YYRPYGVP 416
Query: 843 L-----CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYN----LTIDN 893
+ C+PC+CD C + +G+C CK G C +C YN L I
Sbjct: 417 VDAPDGCIPCSCDPEHADG----CEQGSGRCHCKPNFHGDNCEKCAIGYYNFPFCLRIPI 472
Query: 894 FQ------------HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYIS 941
F + C+C+ G LP ICD G+CLC P +G RC+ C+ GFY
Sbjct: 473 FPVSTPSSEDPVAGDIKGCDCNLEGVLP-EICDA-HGRCLCRPGVEGPRCDTCRSGFYSF 530
Query: 942 PGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQP 1001
P C C C G+ C+S+TGQC C+ + GQRCD+C + F G
Sbjct: 531 PI----CQACWCSALGSYQMPCSSVTGQCECRPG-VTGQRCDRCLSGAYDFPHCQGSSSA 585
Query: 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK 1052
C+ +G +N G C CK V G C C +LD N GCS+
Sbjct: 586 CDP--AGTINSNL----GYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSE 630
Score = 134 bits (337), Expect = 2e-30
Identities = 70/213 (32%), Positives = 98/213 (46%), Gaps = 28/213 (13%)
Query: 584 CHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDC 643
CH + P H GG C C+ N GR C C + CKPC C
Sbjct: 1268 CHPTGATGP----HCSPEGGQCP-CQPNVIGRQCTRCATGHY--------GFPRCKPCSC 1314
Query: 644 DTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVD 703
G LC+++ GQC C QC C+ ++ + GC CNC+ GT++
Sbjct: 1315 -------GRRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMA--GCEGCNCSRRGTIE 1365
Query: 704 GDIT-CHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPH 762
+ C ++SGQC+CK + G +CD C GF + C PC CN G+ C+P
Sbjct: 1366 AAMPECDRDSGQCRCKPRITGRQCDRCASGF-----YRFPECVPCNCNRDGTEPGVCDPG 1420
Query: 763 SGQCECKKEAKGLQCDTCRENFYGLDVTNCKAC 795
+G C CK+ +G +C+ CRE + LD N K C
Sbjct: 1421 TGACLCKENVEGTECNVCREGSFHLDPANLKGC 1453
Score = 130 bits (326), Expect = 4e-29
Identities = 70/211 (33%), Positives = 98/211 (46%), Gaps = 24/211 (11%)
Query: 845 LPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDS 904
LPC C TG C+ GQCPC+ V G +C +C Y F C+ C C
Sbjct: 1264 LPCECHPTGATGPH--CSPEGGQCPCQPNVIGRQCTRCATGHYG-----FPRCKPCSCGR 1316
Query: 905 LGTLPGTICDPISGQCLCVPNRQGRRCNQCQP-GFYISPGNATGCLPCSCHTTGAVNHI- 962
+C+ ++GQC C P +C C+ F P GC C+C G +
Sbjct: 1317 ------RLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHP--MAGCEGCNCSRRGTIEAAM 1368
Query: 963 --CNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQ 1020
C+ +GQC C+ I G++CD+C ++ F C PCNC+ G C TG
Sbjct: 1369 PECDRDSGQCRCKPR-ITGRQCDRCASGFYRFP----ECVPCNCNRDGTEPGVCDPGTGA 1423
Query: 1021 CFCKQFVTGSKCDACVPSASHLDVNNLLGCS 1051
C CK+ V G++C+ C + HLD NL GC+
Sbjct: 1424 CLCKENVEGTECNVCREGSFHLDPANLKGCT 1454
Score = 99.0 bits (245), Expect = 1e-19
Identities = 56/199 (28%), Positives = 89/199 (44%), Gaps = 33/199 (16%)
Query: 537 LCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFE 596
+C+ G C C P Y +R +Y C PC CN HS C
Sbjct: 1653 ICACPPAYAGDSCQGCSPGY----YRDHKGLYTGRCVPCNCNGHSNQC------------ 1696
Query: 597 HFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCD 656
+ G G+C +C+HNT G +CE C++ ++ + C+ C C T + + C
Sbjct: 1697 --QDGSGICVNCQHNTAGEHCERCQEGYYGN-----AVHGSCRACPCPH--TNSFATGCV 1747
Query: 657 QIGG--QCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQ 714
GG +C+CK +G QC +C G++ + C PC+CN++G + +CH +G
Sbjct: 1748 VNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLG---SCHPLTGD 1804
Query: 715 C---KCKANVIGLRCDHCN 730
C + K + CD C+
Sbjct: 1805 CINQEPKDSSPAEECDDCD 1823
Score = 87.4 bits (215), Expect = 3e-16
Identities = 51/158 (32%), Positives = 68/158 (43%), Gaps = 10/158 (6%)
Query: 715 CKCKANVIGLRCDHCNFGF-KFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQC-ECKKEA 772
C C G C C+ G+ + + C PC CN H + C SG C C+
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQ---CQDGSGICVNCQHNT 1710
Query: 773 KGLQCDTCRENFYGLDVT-NCKACDCDTAGSLP-GTVCNAKTGQCICKPNVEGRQCNKCL 830
G C+ C+E +YG V +C+AC C S G V N +C CK G QC +C
Sbjct: 1711 AGEHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCA 1770
Query: 831 EGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQC 868
G F Q C PC+C+ G + C+ TG C
Sbjct: 1771 PGYFGNPQKFGGSCQPCSCNSNGQLGS---CHPLTGDC 1805
Score = 87.0 bits (214), Expect = 4e-16
Identities = 52/179 (29%), Positives = 77/179 (43%), Gaps = 18/179 (10%)
Query: 815 CICKPNVEGRQCNKCLEGNFYLRQNNSFL---CLPCNCDKTGTINGSLLCNKSTGQCP-C 870
C C P G C C G Y R + C+PCNC+ S C +G C C
Sbjct: 1654 CACPPAYAGDSCQGCSPG--YYRDHKGLYTGRCVPCNCN-----GHSNQCQDGSGICVNC 1706
Query: 871 KLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLP-GTICDPISGQCLCVPNRQGR 929
+ G C +C+ Y + C+ C C + G + + +C C G
Sbjct: 1707 QHNTAGEHCERCQEGYYGNAVHG--SCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGT 1764
Query: 930 RCNQCQPGFYISPGNATG-CLPCSCHTTGAVNHICNSLTGQCVCQDA--SIAGQRCDQC 985
+C +C PG++ +P G C PCSC++ G + C+ LTG C+ Q+ S + CD C
Sbjct: 1765 QCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGS-CHPLTGDCINQEPKDSSPAEECDDC 1822
Score = 85.1 bits (209), Expect = 2e-15
Identities = 61/183 (33%), Positives = 81/183 (44%), Gaps = 24/183 (13%)
Query: 868 CPCKLGVTGLRCNQCEPHRYNLTIDNFQ-HCQMCECDSLGTLPGTICDPISGQCL-CVPN 925
C C G C C P Y + C C C+ C SG C+ C N
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQ----CQDGSGICVNCQHN 1709
Query: 926 RQGRRCNQCQPGFYISPGNAT--GCLPCSC-HTTG-AVNHICNSLTGQCVCQDASIAGQR 981
G C +CQ G+Y GNA C C C HT A + N +C C+ A G +
Sbjct: 1710 TAGEHCERCQEGYY---GNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCK-AGYTGTQ 1765
Query: 982 CDQCKDHYFGFDPQT--GRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGS------KCD 1033
C++C YFG +PQ G CQPC+C+ +G L +CH +TG C ++ S CD
Sbjct: 1766 CERCAPGYFG-NPQKFGGSCQPCSCNSNGQLG-SCHPLTGDCINQEPKDSSPAEECDDCD 1823
Query: 1034 ACV 1036
+CV
Sbjct: 1824 SCV 1826
Score = 82.8 bits (203), Expect = 8e-15
Identities = 48/174 (27%), Positives = 70/174 (40%), Gaps = 13/174 (7%)
Query: 766 CECKKEAKGLQCDTCRENFY----GLDVTNCKACDCDTAGSLPGTVCNAKTGQCI-CKPN 820
C C G C C +Y GL C C+C+ + C +G C+ C+ N
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQ----CQDGSGICVNCQHN 1709
Query: 821 VEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCN 880
G C +C EG + + S C C C T + + N +C CK G TG +C
Sbjct: 1710 TAGEHCERCQEGYYGNAVHGS--CRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCE 1767
Query: 881 QCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQC 934
+C P + CQ C C+S G L C P++G C+ + +C
Sbjct: 1768 RCAPGYFGNPQKFGGSCQPCSCNSNGQLGS--CHPLTGDCINQEPKDSSPAEEC 1819
Score = 80.5 bits (197), Expect = 4e-14
Identities = 76/332 (22%), Positives = 138/332 (41%), Gaps = 34/332 (10%)
Query: 1564 GNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITL 1623
G + + AL L KGRL F G + + + ++ +DGKWH ++ G++ +
Sbjct: 3029 GTKNSFMALYLSKGRLVFALGTDGKKLRIKSK----EKCNDGKWHTVVFGHDGEKGRLVV 3084
Query: 1624 DGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMKN-- 1681
DG+ + L G++ I V+LG P K + FVGCLK+
Sbjct: 3085 DGLRAREGS-LPGNSTISIRAPVYLGSPPSG-----KPKSLPTNSFVGCLKNFQLDSKPL 3138
Query: 1682 YNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEIS 1741
Y PS+ + + +Y S EG L G F++
Sbjct: 3139 YTPSSSFGVSSCLGGPLEKGIYFSEEGGHVVLAHSVLL---------------GPEFKLV 3183
Query: 1742 FKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKWN 1801
F R L G+L+ + ++ G L + L++G +T +++ T + S C+G+W+
Sbjct: 3184 FSIRPRSLTGILIHIGSQPG-KHLCVYLEAGKVTASMDSGAGGTSTSVTPKQSLCDGQWH 3242
Query: 1802 KVIIKKEGSFISASVNGLMKH-ASESGDQPLVVNSPVYVGGIPQELLNSYQHLCLEQGFG 1860
V + + + ++ + A + P P+++GG P L + + + + F
Sbjct: 3243 SVAVTIKQHILHLELDTDSSYTAGQIPFPPASTQEPLHLGGAPANL--TTLRIPVWKSFF 3300
Query: 1861 GCMKDVKFTRGAV-VNLASVSSGAVRVNLDGC 1891
GC++++ V V A G V+L+GC
Sbjct: 3301 GCLRNIHVNHIPVPVTEALEVQGP--VSLNGC 3330
Score = 80.1 bits (196), Expect = 5e-14
Identities = 58/203 (28%), Positives = 77/203 (37%), Gaps = 33/203 (16%)
Query: 879 CNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCL-CVPNRQGRRCNQCQPG 937
CN C H N D Q ++ G G G C+ C N G C QC G
Sbjct: 356 CN-CHGHASNCYYDPDVERQQASLNTQGIYAG------GGVCINCQHNTAGVNCEQCAKG 408
Query: 938 FYISPGNAT----GCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGF- 992
+Y G GC+PCSC A C +G+C C+ + G C++C Y+ F
Sbjct: 409 YYRPYGVPVDAPDGCIPCSCDPEHADG--CEQGSGRCHCKP-NFHGDNCEKCAIGYYNFP 465
Query: 993 ----------------DPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACV 1036
DP G + C+C+L G L E C G+C C+ V G +CD C
Sbjct: 466 FCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICD-AHGRCLCRPGVEGPRCDTCR 524
Query: 1037 PSASHLDVNNLLGCSKTPFQQPP 1059
+ CS Q P
Sbjct: 525 SGFYSFPICQACWCSALGSYQMP 547
Score = 79.0 bits (193), Expect = 1e-13
Identities = 53/182 (29%), Positives = 78/182 (42%), Gaps = 24/182 (13%)
Query: 608 CEHNTTGRNCELCKDYFFRQVGADPSAIDV--CKPCDCDTVGTRNGSILCDQIGGQC-NC 664
C G +C+ C ++R D + C PC+C+ S C G C NC
Sbjct: 1656 CPPAYAGDSCQGCSPGYYR----DHKGLYTGRCVPCNCN-----GHSNQCQDGSGICVNC 1706
Query: 665 KRHVSGRQCNQCQNGFYNLQELDPDGCSPCNC-NTSGTVDGDITCHQNSG--QCKCKANV 721
+ + +G C +CQ G+Y C C C +T+ G C N G +C CKA
Sbjct: 1707 QHNTAGEHCERCQEGYYG--NAVHGSCRACPCPHTNSFATG---CVVNGGDVRCSCKAGY 1761
Query: 722 IGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQC---ECKKEAKGLQCD 778
G +C+ C G+ C+PC CN +G + C+P +G C E K + +CD
Sbjct: 1762 TGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGS-CHPLTGDCINQEPKDSSPAEECD 1820
Query: 779 TC 780
C
Sbjct: 1821 DC 1822
Score = 75.5 bits (184), Expect = 1e-12
Identities = 42/122 (34%), Positives = 63/122 (51%), Gaps = 8/122 (6%)
Query: 920 CLCVPNRQGRRCNQCQPGFYIS-PGNATG-CLPCSCHTTGAVNHICNSLTGQCVCQDASI 977
C C P G C C PG+Y G TG C+PC+C+ G N C +G CV +
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCN--GHSNQ-CQDGSGICVNCQHNT 1710
Query: 978 AGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTG--QCFCKQFVTGSKCDAC 1035
AG+ C++C++ Y+G + G C+ C C + + C + G +C CK TG++C+ C
Sbjct: 1711 AGEHCERCQEGYYG-NAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERC 1769
Query: 1036 VP 1037
P
Sbjct: 1770 AP 1771
Score = 71.6 bits (174), Expect = 2e-11
Identities = 33/89 (37%), Positives = 46/89 (51%), Gaps = 10/89 (11%)
Query: 947 GCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHL 1006
G LPC CH TGA C+ GQC CQ ++ G++C +C ++GF RC+PC+C
Sbjct: 1262 GALPCECHPTGATGPHCSPEGGQCPCQ-PNVIGRQCTRCATGHYGFP----RCKPCSCG- 1315
Query: 1007 SGALNETCHLVTGQCFCKQFVTGSKCDAC 1035
C +TGQC C +C+ C
Sbjct: 1316 ----RRLCEEMTGQCRCPPRTVRPQCEVC 1340
Score = 58.2 bits (139), Expect = 2e-07
Identities = 50/182 (27%), Positives = 72/182 (39%), Gaps = 38/182 (20%)
Query: 506 YYAVDEITISGRC---QCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFR 562
YY + +GRC C+GH++ C S C+ Q + T G HC+RC Y
Sbjct: 1672 YYRDHKGLYTGRCVPCNCNGHSNQCQDGSG--ICVNCQHN-TAGEHCERCQEGY------ 1722
Query: 563 QGDQVYAFNCKPCQC---NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCEL 619
G+ V+ +C+ C C NS + C N GG V C+ TG CE
Sbjct: 1723 YGNAVHG-SCRACPCPHTNSFATGCVVN-------------GGDVRCSCKAGYTGTQCER 1768
Query: 620 CKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC---NCKRHVSGRQCNQC 676
C +F G C+PC C++ G C + G C K +C+ C
Sbjct: 1769 CAPGYF---GNPQKFGGSCQPCSCNSNGQLGS---CHPLTGDCINQEPKDSSPAEECDDC 1822
Query: 677 QN 678
+
Sbjct: 1823 DS 1824
>gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens]
Length = 3277
Score = 325 bits (833), Expect = 7e-88
Identities = 201/637 (31%), Positives = 297/637 (46%), Gaps = 61/637 (9%)
Query: 338 EAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTISVDLENGQ-YQVFYIIIQFF-SPQPT 395
+AHP++ D W S ++ TQ N+ +++ L+ GQ + V YI+I+F SP+P
Sbjct: 112 KAHPVTNAIDGSERW-WQSPPLSSGTQYNR---VNLTLDLGQLFHVAYILIKFANSPRPD 167
Query: 396 EIRIQRKKENSLDWEDWQYFARN----CGAFGMKNNGDLEKPDSVNCL-QLSNFTPYSRG 450
++R + + WQYFA + FG + N + + D V C+ + S P G
Sbjct: 168 LWVLERSVDFGSTYSPWQYFAHSKVDCLKEFGREANMAVTRDDDVLCVTEYSRIVPLENG 227
Query: 451 NVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHF--------HGQYYTTETAVNL 502
V S++ N RPG NF + +L+EF KAT IR F H
Sbjct: 228 EVVVSLI----NGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQRDPTVT 283
Query: 503 RHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFR 562
R YY++ +I+I G+C C+GHA+ C+ + C + T G CDRC YN + +R
Sbjct: 284 RRYYYSIKDISIGGQCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWR 343
Query: 563 QGDQVYAFNCKPCQCNSHSKSCHYNISVD----PFPFEHFRGGGGVCDDCEHNTTGRNCE 618
+ C+ C C+ H+ +C+Y+ V+ + GGGVC +C+HNT G NCE
Sbjct: 344 PAAWEQSHECEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCE 403
Query: 619 LCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQN 678
C ++R G A D C PC CD C+Q G+C+CK + G C +C
Sbjct: 404 QCAKGYYRPYGVPVDAPDGCIPCSCDPEHADG----CEQGSGRCHCKPNFHGDNCEKCAI 459
Query: 679 GFYNL--------------QELDP--DGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVI 722
G+YN DP C+CN G + H G+C C+ V
Sbjct: 460 GYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICDAH---GRCLCRPGVE 516
Query: 723 GLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRE 782
G RCD C GF ++ C+ C C+ GS C+ +GQCEC+ G +CD C
Sbjct: 517 GPRCDTCRSGF-----YSFPICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCDRCLS 571
Query: 783 NFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSF 842
Y + CD AG++ N+ G C CK +VEG C++C + L + N
Sbjct: 572 GAYDFPHCQGSSSACDPAGTI-----NSNLGYCQCKLHVEGPTCSRCKLLYWNLDKENPS 626
Query: 843 LCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCEC 902
C C C K GT++G+ C + G C CK V G C+ CE + L N+ CQ C+C
Sbjct: 627 GCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQC 686
Query: 903 DSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFY 939
D G L ++C SG C C + G+ C + + +Y
Sbjct: 687 DIGGAL-SSMCSGPSGVCQCREHVVGKVCQRPENNYY 722
Score = 160 bits (404), Expect = 4e-38
Identities = 85/239 (35%), Positives = 113/239 (47%), Gaps = 21/239 (8%)
Query: 729 CNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLD 788
C + L +F G PC+C+ G+ C+P GQC C+ G QC C YG
Sbjct: 1248 CKNSARSLVAFYHKGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGF- 1306
Query: 789 VTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCN 848
CK C C +C TGQC C P QC C +F C CN
Sbjct: 1307 -PRCKPCSCGR------RLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAG--CEGCN 1357
Query: 849 CDKTGTINGSL-LCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGT 907
C + GTI ++ C++ +GQC CK +TG +C++C Y F C C C+ GT
Sbjct: 1358 CSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFY-----RFPECVPCNCNRDGT 1412
Query: 908 LPGTICDPISGQCLCVPNRQGRRCNQCQPG-FYISPGNATGCLPCSCHTTGAVNHICNS 965
PG +CDP +G CLC N +G CN C+ G F++ P N GC C C VN+ C+S
Sbjct: 1413 EPG-VCDPGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFCF---GVNNQCHS 1467
Score = 159 bits (403), Expect = 5e-38
Identities = 120/421 (28%), Positives = 176/421 (41%), Gaps = 76/421 (18%)
Query: 680 FYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSF 739
+Y+++++ G C CN V +I + +C+C+ + G CD C G+ R
Sbjct: 287 YYSIKDISIGG--QCVCNGHAEVC-NINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWR 343
Query: 740 -----NDVGCEPCQCNLHGSVNKFCNPH----------------SGQC-ECKKEAKGLQC 777
CE C C+ H S N + +P G C C+ G+ C
Sbjct: 344 PAAWEQSHECEACNCHGHAS-NCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNC 402
Query: 778 DTCRENFY---GLDVT---NCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLE 831
+ C + +Y G+ V C C CD + C +G+C CKPN G C KC
Sbjct: 403 EQCAKGYYRPYGVPVDAPDGCIPCSCDPEHA---DGCEQGSGRCHCKPNFHGDNCEKCAI 459
Query: 832 GN----FYLRQNNSFLCLP------------CNCDKTGTINGSLLCNKSTGQCPCKLGVT 875
G F LR + P C+C+ G + +C+ + G+C C+ GV
Sbjct: 460 GYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPE--ICD-AHGRCLCRPGVE 516
Query: 876 GLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQ 935
G RC+ C Y+ I CQ C C +LG+ C ++GQC C P G+RC++C
Sbjct: 517 GPRCDTCRSGFYSFPI-----CQACWCSALGSYQMP-CSSVTGQCECRPGVTGQRCDRCL 570
Query: 936 PGFYISP---GNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGF 992
G Y P G+++ C P NS G C C+ + G C +CK Y+
Sbjct: 571 SGAYDFPHCQGSSSACDPAGT---------INSNLGYCQCK-LHVEGPTCSRCKLLYWNL 620
Query: 993 DPQT-GRCQPCNCHLSGALNET--CHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLG 1049
D + C C CH +G ++ T C G C CK V G CD C L+ +N G
Sbjct: 621 DKENPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFG 680
Query: 1050 C 1050
C
Sbjct: 681 C 681
Score = 153 bits (386), Expect = 5e-36
Identities = 80/216 (37%), Positives = 105/216 (48%), Gaps = 28/216 (12%)
Query: 640 PCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTS 699
PC+C G C GGQC C+ +V GRQC +C G Y C PC+C
Sbjct: 1265 PCECHPTGATGPH--CSPEGGQCPCQPNVIGRQCTRCATGHYGFPR-----CKPCSC--- 1314
Query: 700 GTVDGDITCHQNSGQCKCKANVIGLRCDHC---NFGFKFLRSFNDVGCEPCQCNLHGSVN 756
G C + +GQC+C + +C+ C +F F + GCE C C+ G++
Sbjct: 1315 ----GRRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPM-----AGCEGCNCSRRGTIE 1365
Query: 757 KF---CNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTG 813
C+ SGQC CK G QCD C FY C C+C+ G+ PG VC+ TG
Sbjct: 1366 AAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFP--ECVPCNCNRDGTEPG-VCDPGTG 1422
Query: 814 QCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNC 849
C+CK NVEG +CN C EG+F+L N C C C
Sbjct: 1423 ACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFC 1458
Score = 147 bits (372), Expect = 2e-34
Identities = 75/231 (32%), Positives = 109/231 (47%), Gaps = 24/231 (10%)
Query: 676 CQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFG-FK 734
C+N +L G PC C+ +G C GQC C+ NVIG +C C G +
Sbjct: 1248 CKNSARSLVAFYHKGALPCECHPTGATGPH--CSPEGGQCPCQPNVIGRQCTRCATGHYG 1305
Query: 735 FLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGL-DVTNCK 793
F R C+PC C + C +GQC C QC+ C + + + C+
Sbjct: 1306 FPR------CKPCSCG-----RRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCE 1354
Query: 794 ACDCDTAGSLPGTV--CNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDK 851
C+C G++ + C+ +GQC CKP + GRQC++C G + + C+PCNC++
Sbjct: 1355 GCNCSRRGTIEAAMPECDRDSGQCRCKPRITGRQCDRCASGFYRFPE-----CVPCNCNR 1409
Query: 852 TGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCEC 902
GT G +C+ TG C CK V G CN C ++L N + C C C
Sbjct: 1410 DGTEPG--VCDPGTGACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFC 1458
Score = 142 bits (358), Expect = 9e-33
Identities = 81/261 (31%), Positives = 114/261 (43%), Gaps = 40/261 (15%)
Query: 535 RCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFP 594
RCLC EG CD C + P Q A C+S + C
Sbjct: 508 RCLCRPG--VEGPRCDTCRSGFYSFPICQACWCSALGSYQMPCSSVTGQC---------- 555
Query: 595 FEHFRGGGGVCDDCEHNTTGRNCELCKD--YFFRQVGADPSAIDVCKPCDCDTVGTRNGS 652
+C TG+ C+ C Y F SA CD GT N +
Sbjct: 556 ------------ECRPGVTGQRCDRCLSGAYDFPHCQGSSSA--------CDPAGTINSN 595
Query: 653 ILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNS 712
+ G C CK HV G C++C+ ++NL + +P GCS C C+ +GTV G C Q
Sbjct: 596 L------GYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKCHKAGTVSGTGECRQGD 649
Query: 713 GQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEA 772
G C CK++V G CD C G+ L N GC+ CQC++ G+++ C+ SG C+C++
Sbjct: 650 GDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCREHV 709
Query: 773 KGLQCDTCRENFYGLDVTNCK 793
G C N+Y D+ + K
Sbjct: 710 VGKVCQRPENNYYFPDLHHMK 730
Score = 138 bits (347), Expect = 2e-31
Identities = 107/351 (30%), Positives = 141/351 (40%), Gaps = 64/351 (18%)
Query: 747 CQCNLHGSVNKFCNPHS-GQCECKKEAKGLQCDTCRENFYGL--------DVTNCKACDC 797
C CN H V NP +CEC+ G CD C + C+AC+C
Sbjct: 299 CVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNC 358
Query: 798 D--------------TAGSLPGTVCNAKTGQCI-CKPNVEGRQCNKCLEGNFYLRQNNSF 842
SL A G CI C+ N G C +C +G Y R
Sbjct: 359 HGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKG--YYRPYGVP 416
Query: 843 L-----CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYN----LTIDN 893
+ C+PC+CD C + +G+C CK G C +C YN L I
Sbjct: 417 VDAPDGCIPCSCDPEHADG----CEQGSGRCHCKPNFHGDNCEKCAIGYYNFPFCLRIPI 472
Query: 894 FQ------------HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYIS 941
F + C+C+ G LP ICD G+CLC P +G RC+ C+ GFY
Sbjct: 473 FPVSTPSSEDPVAGDIKGCDCNLEGVLP-EICDA-HGRCLCRPGVEGPRCDTCRSGFYSF 530
Query: 942 PGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQP 1001
P C C C G+ C+S+TGQC C+ + GQRCD+C + F G
Sbjct: 531 PI----CQACWCSALGSYQMPCSSVTGQCECRPG-VTGQRCDRCLSGAYDFPHCQGSSSA 585
Query: 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK 1052
C+ +G +N G C CK V G C C +LD N GCS+
Sbjct: 586 CDP--AGTINSNL----GYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSE 630
Score = 134 bits (337), Expect = 2e-30
Identities = 70/213 (32%), Positives = 98/213 (46%), Gaps = 28/213 (13%)
Query: 584 CHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDC 643
CH + P H GG C C+ N GR C C + CKPC C
Sbjct: 1268 CHPTGATGP----HCSPEGGQCP-CQPNVIGRQCTRCATGHY--------GFPRCKPCSC 1314
Query: 644 DTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVD 703
G LC+++ GQC C QC C+ ++ + GC CNC+ GT++
Sbjct: 1315 -------GRRLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMA--GCEGCNCSRRGTIE 1365
Query: 704 GDIT-CHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPH 762
+ C ++SGQC+CK + G +CD C GF + C PC CN G+ C+P
Sbjct: 1366 AAMPECDRDSGQCRCKPRITGRQCDRCASGF-----YRFPECVPCNCNRDGTEPGVCDPG 1420
Query: 763 SGQCECKKEAKGLQCDTCRENFYGLDVTNCKAC 795
+G C CK+ +G +C+ CRE + LD N K C
Sbjct: 1421 TGACLCKENVEGTECNVCREGSFHLDPANLKGC 1453
Score = 130 bits (326), Expect = 4e-29
Identities = 70/211 (33%), Positives = 98/211 (46%), Gaps = 24/211 (11%)
Query: 845 LPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDS 904
LPC C TG C+ GQCPC+ V G +C +C Y F C+ C C
Sbjct: 1264 LPCECHPTGATGPH--CSPEGGQCPCQPNVIGRQCTRCATGHYG-----FPRCKPCSCGR 1316
Query: 905 LGTLPGTICDPISGQCLCVPNRQGRRCNQCQP-GFYISPGNATGCLPCSCHTTGAVNHI- 962
+C+ ++GQC C P +C C+ F P GC C+C G +
Sbjct: 1317 ------RLCEEMTGQCRCPPRTVRPQCEVCETHSFSFHP--MAGCEGCNCSRRGTIEAAM 1368
Query: 963 --CNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQ 1020
C+ +GQC C+ I G++CD+C ++ F C PCNC+ G C TG
Sbjct: 1369 PECDRDSGQCRCKPR-ITGRQCDRCASGFYRFP----ECVPCNCNRDGTEPGVCDPGTGA 1423
Query: 1021 CFCKQFVTGSKCDACVPSASHLDVNNLLGCS 1051
C CK+ V G++C+ C + HLD NL GC+
Sbjct: 1424 CLCKENVEGTECNVCREGSFHLDPANLKGCT 1454
Score = 99.0 bits (245), Expect = 1e-19
Identities = 56/199 (28%), Positives = 89/199 (44%), Gaps = 33/199 (16%)
Query: 537 LCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFE 596
+C+ G C C P Y +R +Y C PC CN HS C
Sbjct: 1653 ICACPPAYAGDSCQGCSPGY----YRDHKGLYTGRCVPCNCNGHSNQC------------ 1696
Query: 597 HFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCD 656
+ G G+C +C+HNT G +CE C++ ++ + C+ C C T + + C
Sbjct: 1697 --QDGSGICVNCQHNTAGEHCERCQEGYYGN-----AVHGSCRACPCPH--TNSFATGCV 1747
Query: 657 QIGG--QCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQ 714
GG +C+CK +G QC +C G++ + C PC+CN++G + +CH +G
Sbjct: 1748 VNGGDVRCSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLG---SCHPLTGD 1804
Query: 715 C---KCKANVIGLRCDHCN 730
C + K + CD C+
Sbjct: 1805 CINQEPKDSSPAEECDDCD 1823
Score = 87.4 bits (215), Expect = 3e-16
Identities = 51/158 (32%), Positives = 68/158 (43%), Gaps = 10/158 (6%)
Query: 715 CKCKANVIGLRCDHCNFGF-KFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQC-ECKKEA 772
C C G C C+ G+ + + C PC CN H + C SG C C+
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQ---CQDGSGICVNCQHNT 1710
Query: 773 KGLQCDTCRENFYGLDVT-NCKACDCDTAGSLP-GTVCNAKTGQCICKPNVEGRQCNKCL 830
G C+ C+E +YG V +C+AC C S G V N +C CK G QC +C
Sbjct: 1711 AGEHCERCQEGYYGNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERCA 1770
Query: 831 EGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQC 868
G F Q C PC+C+ G + C+ TG C
Sbjct: 1771 PGYFGNPQKFGGSCQPCSCNSNGQLGS---CHPLTGDC 1805
Score = 87.0 bits (214), Expect = 4e-16
Identities = 52/179 (29%), Positives = 77/179 (43%), Gaps = 18/179 (10%)
Query: 815 CICKPNVEGRQCNKCLEGNFYLRQNNSFL---CLPCNCDKTGTINGSLLCNKSTGQCP-C 870
C C P G C C G Y R + C+PCNC+ S C +G C C
Sbjct: 1654 CACPPAYAGDSCQGCSPG--YYRDHKGLYTGRCVPCNCN-----GHSNQCQDGSGICVNC 1706
Query: 871 KLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLP-GTICDPISGQCLCVPNRQGR 929
+ G C +C+ Y + C+ C C + G + + +C C G
Sbjct: 1707 QHNTAGEHCERCQEGYYGNAVHG--SCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGT 1764
Query: 930 RCNQCQPGFYISPGNATG-CLPCSCHTTGAVNHICNSLTGQCVCQDA--SIAGQRCDQC 985
+C +C PG++ +P G C PCSC++ G + C+ LTG C+ Q+ S + CD C
Sbjct: 1765 QCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGS-CHPLTGDCINQEPKDSSPAEECDDC 1822
Score = 85.1 bits (209), Expect = 2e-15
Identities = 61/183 (33%), Positives = 81/183 (44%), Gaps = 24/183 (13%)
Query: 868 CPCKLGVTGLRCNQCEPHRYNLTIDNFQ-HCQMCECDSLGTLPGTICDPISGQCL-CVPN 925
C C G C C P Y + C C C+ C SG C+ C N
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQ----CQDGSGICVNCQHN 1709
Query: 926 RQGRRCNQCQPGFYISPGNAT--GCLPCSC-HTTG-AVNHICNSLTGQCVCQDASIAGQR 981
G C +CQ G+Y GNA C C C HT A + N +C C+ A G +
Sbjct: 1710 TAGEHCERCQEGYY---GNAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCK-AGYTGTQ 1765
Query: 982 CDQCKDHYFGFDPQT--GRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGS------KCD 1033
C++C YFG +PQ G CQPC+C+ +G L +CH +TG C ++ S CD
Sbjct: 1766 CERCAPGYFG-NPQKFGGSCQPCSCNSNGQLG-SCHPLTGDCINQEPKDSSPAEECDDCD 1823
Query: 1034 ACV 1036
+CV
Sbjct: 1824 SCV 1826
Score = 82.8 bits (203), Expect = 8e-15
Identities = 48/174 (27%), Positives = 70/174 (40%), Gaps = 13/174 (7%)
Query: 766 CECKKEAKGLQCDTCRENFY----GLDVTNCKACDCDTAGSLPGTVCNAKTGQCI-CKPN 820
C C G C C +Y GL C C+C+ + C +G C+ C+ N
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQ----CQDGSGICVNCQHN 1709
Query: 821 VEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCN 880
G C +C EG + + S C C C T + + N +C CK G TG +C
Sbjct: 1710 TAGEHCERCQEGYYGNAVHGS--CRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCE 1767
Query: 881 QCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQC 934
+C P + CQ C C+S G L C P++G C+ + +C
Sbjct: 1768 RCAPGYFGNPQKFGGSCQPCSCNSNGQLGS--CHPLTGDCINQEPKDSSPAEEC 1819
Score = 80.5 bits (197), Expect = 4e-14
Identities = 76/332 (22%), Positives = 138/332 (41%), Gaps = 34/332 (10%)
Query: 1564 GNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITL 1623
G + + AL L KGRL F G + + + ++ +DGKWH ++ G++ +
Sbjct: 2973 GTKNSFMALYLSKGRLVFALGTDGKKLRIKSK----EKCNDGKWHTVVFGHDGEKGRLVV 3028
Query: 1624 DGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMKN-- 1681
DG+ + L G++ I V+LG P K + FVGCLK+
Sbjct: 3029 DGLRAREGS-LPGNSTISIRAPVYLGSPPSG-----KPKSLPTNSFVGCLKNFQLDSKPL 3082
Query: 1682 YNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEIS 1741
Y PS+ + + +Y S EG L G F++
Sbjct: 3083 YTPSSSFGVSSCLGGPLEKGIYFSEEGGHVVLAHSVLL---------------GPEFKLV 3127
Query: 1742 FKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKWN 1801
F R L G+L+ + ++ G L + L++G +T +++ T + S C+G+W+
Sbjct: 3128 FSIRPRSLTGILIHIGSQPG-KHLCVYLEAGKVTASMDSGAGGTSTSVTPKQSLCDGQWH 3186
Query: 1802 KVIIKKEGSFISASVNGLMKH-ASESGDQPLVVNSPVYVGGIPQELLNSYQHLCLEQGFG 1860
V + + + ++ + A + P P+++GG P L + + + + F
Sbjct: 3187 SVAVTIKQHILHLELDTDSSYTAGQIPFPPASTQEPLHLGGAPANL--TTLRIPVWKSFF 3244
Query: 1861 GCMKDVKFTRGAV-VNLASVSSGAVRVNLDGC 1891
GC++++ V V A G V+L+GC
Sbjct: 3245 GCLRNIHVNHIPVPVTEALEVQGP--VSLNGC 3274
Score = 80.1 bits (196), Expect = 5e-14
Identities = 58/203 (28%), Positives = 77/203 (37%), Gaps = 33/203 (16%)
Query: 879 CNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCL-CVPNRQGRRCNQCQPG 937
CN C H N D Q ++ G G G C+ C N G C QC G
Sbjct: 356 CN-CHGHASNCYYDPDVERQQASLNTQGIYAG------GGVCINCQHNTAGVNCEQCAKG 408
Query: 938 FYISPGNAT----GCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGF- 992
+Y G GC+PCSC A C +G+C C+ + G C++C Y+ F
Sbjct: 409 YYRPYGVPVDAPDGCIPCSCDPEHADG--CEQGSGRCHCKP-NFHGDNCEKCAIGYYNFP 465
Query: 993 ----------------DPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACV 1036
DP G + C+C+L G L E C G+C C+ V G +CD C
Sbjct: 466 FCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEICD-AHGRCLCRPGVEGPRCDTCR 524
Query: 1037 PSASHLDVNNLLGCSKTPFQQPP 1059
+ CS Q P
Sbjct: 525 SGFYSFPICQACWCSALGSYQMP 547
Score = 79.0 bits (193), Expect = 1e-13
Identities = 53/182 (29%), Positives = 78/182 (42%), Gaps = 24/182 (13%)
Query: 608 CEHNTTGRNCELCKDYFFRQVGADPSAIDV--CKPCDCDTVGTRNGSILCDQIGGQC-NC 664
C G +C+ C ++R D + C PC+C+ S C G C NC
Sbjct: 1656 CPPAYAGDSCQGCSPGYYR----DHKGLYTGRCVPCNCN-----GHSNQCQDGSGICVNC 1706
Query: 665 KRHVSGRQCNQCQNGFYNLQELDPDGCSPCNC-NTSGTVDGDITCHQNSG--QCKCKANV 721
+ + +G C +CQ G+Y C C C +T+ G C N G +C CKA
Sbjct: 1707 QHNTAGEHCERCQEGYYG--NAVHGSCRACPCPHTNSFATG---CVVNGGDVRCSCKAGY 1761
Query: 722 IGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQC---ECKKEAKGLQCD 778
G +C+ C G+ C+PC CN +G + C+P +G C E K + +CD
Sbjct: 1762 TGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQLGS-CHPLTGDCINQEPKDSSPAEECD 1820
Query: 779 TC 780
C
Sbjct: 1821 DC 1822
Score = 75.5 bits (184), Expect = 1e-12
Identities = 42/122 (34%), Positives = 63/122 (51%), Gaps = 8/122 (6%)
Query: 920 CLCVPNRQGRRCNQCQPGFYIS-PGNATG-CLPCSCHTTGAVNHICNSLTGQCVCQDASI 977
C C P G C C PG+Y G TG C+PC+C+ G N C +G CV +
Sbjct: 1654 CACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCN--GHSNQ-CQDGSGICVNCQHNT 1710
Query: 978 AGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTG--QCFCKQFVTGSKCDAC 1035
AG+ C++C++ Y+G + G C+ C C + + C + G +C CK TG++C+ C
Sbjct: 1711 AGEHCERCQEGYYG-NAVHGSCRACPCPHTNSFATGCVVNGGDVRCSCKAGYTGTQCERC 1769
Query: 1036 VP 1037
P
Sbjct: 1770 AP 1771
Score = 71.6 bits (174), Expect = 2e-11
Identities = 33/89 (37%), Positives = 46/89 (51%), Gaps = 10/89 (11%)
Query: 947 GCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHL 1006
G LPC CH TGA C+ GQC CQ ++ G++C +C ++GF RC+PC+C
Sbjct: 1262 GALPCECHPTGATGPHCSPEGGQCPCQ-PNVIGRQCTRCATGHYGFP----RCKPCSCG- 1315
Query: 1007 SGALNETCHLVTGQCFCKQFVTGSKCDAC 1035
C +TGQC C +C+ C
Sbjct: 1316 ----RRLCEEMTGQCRCPPRTVRPQCEVC 1340
Score = 58.2 bits (139), Expect = 2e-07
Identities = 50/182 (27%), Positives = 72/182 (39%), Gaps = 38/182 (20%)
Query: 506 YYAVDEITISGRC---QCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFR 562
YY + +GRC C+GH++ C S C+ Q + T G HC+RC Y
Sbjct: 1672 YYRDHKGLYTGRCVPCNCNGHSNQCQDGSG--ICVNCQHN-TAGEHCERCQEGY------ 1722
Query: 563 QGDQVYAFNCKPCQC---NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCEL 619
G+ V+ +C+ C C NS + C N GG V C+ TG CE
Sbjct: 1723 YGNAVHG-SCRACPCPHTNSFATGCVVN-------------GGDVRCSCKAGYTGTQCER 1768
Query: 620 CKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC---NCKRHVSGRQCNQC 676
C +F G C+PC C++ G C + G C K +C+ C
Sbjct: 1769 CAPGYF---GNPQKFGGSCQPCSCNSNGQLGS---CHPLTGDCINQEPKDSSPAEECDDC 1822
Query: 677 QN 678
+
Sbjct: 1823 DS 1824
>gi|62868217 laminin, beta 3 precursor [Homo sapiens]
Length = 1172
Score = 298 bits (762), Expect = 1e-79
Identities = 164/499 (32%), Positives = 253/499 (50%), Gaps = 38/499 (7%)
Query: 369 VTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC-GAFGMKNN 427
V++ +DL+ ++Q+ ++++F P P + I+R + W +QY A +C F
Sbjct: 104 VSLQLDLDR-RFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQ 162
Query: 428 GDLEKPDSVNCLQLSNFTPYSR---GNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQ 484
G + V C L P +R G V +++ + +QE + T
Sbjct: 163 GRPQSWQDVRCQSLPQ-RPNARLNGGKVQLNLMDLVSGIPATQSQ-----KIQEVGEITN 216
Query: 485 IRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNC---------DTTSQPYR 535
+R +F + + YYAV ++ + G C CHGHAD C +T+
Sbjct: 217 LRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVH 276
Query: 536 CLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPF 595
+C + T G +C+RC P YN++P+R + A C+ C CN HS++CH+ DP F
Sbjct: 277 DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHF----DPAVF 332
Query: 596 EHFRGG-GGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSIL 654
+G GGVCD+C +T G+NCE C+ ++FR S + C C+CD G G+
Sbjct: 333 AASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGA-P 391
Query: 655 CDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQ 714
CD + GQC CK HV G +C+ C+ GF L +P GC C+CN G+ D+ C + SG+
Sbjct: 392 CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGS-RRDMPCDEESGR 450
Query: 715 CKCKANVIGLRCDHC-NFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAK 773
C C NV+G +CD C + +K + GCEPC C+ H S++ CN +GQC C++
Sbjct: 451 CLCLPNVVGPKCDQCAPYHWKLA---SGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFG 507
Query: 774 GLQCDT-----CRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNK 828
GL C C + YG T C+ACDCD G+ G C+ +G+C+C+P + G +C++
Sbjct: 508 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGT-EGPGCDKASGRCLCRPGLTGPRCDQ 566
Query: 829 CLEGNFYLRQNNSFLCLPC 847
C G + R C PC
Sbjct: 567 CQRG-YCNRYPVCVACHPC 584
Score = 179 bits (453), Expect = 8e-44
Identities = 110/336 (32%), Positives = 154/336 (45%), Gaps = 46/336 (13%)
Query: 647 GTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYN------LQELDPDGCSPCNCNTSG 700
G G Q+ C C+ + +G C +C FYN + D C C+CN
Sbjct: 264 GASAGPSTAVQVHDVCVCQHNTAGPNCERCAP-FYNNRPWRPAEGQDAHECQRCDCNGHS 322
Query: 701 TVDGDITCHQN-----------SGQC-KCKANVIGLRCDHCNFGFKFLR----SFNDVGC 744
TCH + G C C+ + G C+ C + R S + C
Sbjct: 323 E-----TCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQET-C 376
Query: 745 EPCQCNLHGSV-NKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTN---CKACDCDTA 800
C+C+ G+V C+P +GQC CK+ +G +CD C+ F GL N C CDC+
Sbjct: 377 ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNIL 436
Query: 801 GSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLL 860
GS C+ ++G+C+C PNV G +C++C ++ L C PC CD +++
Sbjct: 437 GSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQG--CEPCACDPHNSLSPQ-- 492
Query: 861 CNKSTGQCPCKLGVTGLRCN-----QCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDP 915
CN+ TGQCPC+ G GL C+ QC Y D C+ C+CD GT G CD
Sbjct: 493 CNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYG---DVATGCRACDCDFRGT-EGPGCDK 548
Query: 916 ISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPC 951
SG+CLC P G RC+QCQ G+ C PC
Sbjct: 549 ASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPC 584
Score = 177 bits (449), Expect = 2e-43
Identities = 107/325 (32%), Positives = 150/325 (46%), Gaps = 45/325 (13%)
Query: 749 CNLHGSVNKFCNPHSGQ-------------CECKKEAKGLQCDTCRENFY---------G 786
C HG ++ C P G C C+ G C+ C FY G
Sbjct: 250 CFCHGHADR-CAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAP-FYNNRPWRPAEG 307
Query: 787 LDVTNCKACDC----DTAGSLPGTVC---NAKTGQCI-CKPNVEGRQCNKCLEGNFYLRQ 838
D C+ CDC +T P A G C C+ + EG+ C +C F R+
Sbjct: 308 QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRR 367
Query: 839 NNSFL---CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQ 895
+ + C+ C CD G + G+ C+ TGQC CK V G RC+ C+P LT N Q
Sbjct: 368 PGASIQETCISCECDPDGAVPGAP-CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQ 426
Query: 896 HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHT 955
C C+C+ LG+ CD SG+CLC+PN G +C+QC P ++ + GC PC+C
Sbjct: 427 GCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDP 485
Query: 956 TGAVNHICNSLTGQCVCQDASIAGQRCD-----QCKDHYFGFDPQTGRCQPCNCHLSGAL 1010
+++ CN TGQC C++ G C QC D +G D TG C+ C+C G
Sbjct: 486 HNSLSPQCNQFTGQCPCRE-GFGGLMCSAAAIRQCPDRTYG-DVATG-CRACDCDFRGTE 542
Query: 1011 NETCHLVTGQCFCKQFVTGSKCDAC 1035
C +G+C C+ +TG +CD C
Sbjct: 543 GPGCDKASGRCLCRPGLTGPRCDQC 567
Score = 91.3 bits (225), Expect = 2e-17
Identities = 60/199 (30%), Positives = 90/199 (45%), Gaps = 39/199 (19%)
Query: 868 CPCKLGVTGLRCNQCEPHRYNLTI-----DNFQHCQMCECD---------------SLGT 907
C C+ G C +C P N + CQ C+C+ S G
Sbjct: 279 CVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGA 338
Query: 908 LPGTICDPISGQCLCVPNRQGRRCNQCQPGFYIS--PGNATG--CLPCSCHTTGAVNHI- 962
G +CD C + +G+ C +CQ ++ + PG + C+ C C GAV
Sbjct: 339 YGG-VCDN------CRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAP 391
Query: 963 CNSLTGQCVCQDASIAGQRCDQCKDHYFGF---DPQTGRCQPCNCHLSGALNET-CHLVT 1018
C+ +TGQCVC++ + G+RCD CK + G +PQ C C+C++ G+ + C +
Sbjct: 392 CDPVTGQCVCKE-HVQGERCDLCKPGFTGLTYANPQG--CHRCDCNILGSRRDMPCDEES 448
Query: 1019 GQCFCKQFVTGSKCDACVP 1037
G+C C V G KCD C P
Sbjct: 449 GRCLCLPNVVGPKCDQCAP 467
Score = 72.0 bits (175), Expect = 1e-11
Identities = 52/182 (28%), Positives = 73/182 (40%), Gaps = 40/182 (21%)
Query: 903 DSLGTLPGTICDP-----ISGQCLCVPNRQGRRCNQCQPGFYISPG------NATGCLPC 951
D PG P + C+C N G C +C P + P +A C C
Sbjct: 257 DRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRC 316
Query: 952 SCH---------------TTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYF-----G 991
C+ + GA +C++ C+D + G+ C++C+ HYF G
Sbjct: 317 DCNGHSETCHFDPAVFAASQGAYGGVCDN------CRDHT-EGKNCERCQLHYFRNRRPG 369
Query: 992 FDPQTGRCQPCNCHLSGAL-NETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050
Q C C C GA+ C VTGQC CK+ V G +CD C P + L N GC
Sbjct: 370 ASIQE-TCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGC 428
Query: 1051 SK 1052
+
Sbjct: 429 HR 430
>gi|62868215 laminin, beta 3 precursor [Homo sapiens]
Length = 1172
Score = 298 bits (762), Expect = 1e-79
Identities = 164/499 (32%), Positives = 253/499 (50%), Gaps = 38/499 (7%)
Query: 369 VTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC-GAFGMKNN 427
V++ +DL+ ++Q+ ++++F P P + I+R + W +QY A +C F
Sbjct: 104 VSLQLDLDR-RFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQ 162
Query: 428 GDLEKPDSVNCLQLSNFTPYSR---GNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQ 484
G + V C L P +R G V +++ + +QE + T
Sbjct: 163 GRPQSWQDVRCQSLPQ-RPNARLNGGKVQLNLMDLVSGIPATQSQ-----KIQEVGEITN 216
Query: 485 IRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNC---------DTTSQPYR 535
+R +F + + YYAV ++ + G C CHGHAD C +T+
Sbjct: 217 LRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVH 276
Query: 536 CLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPF 595
+C + T G +C+RC P YN++P+R + A C+ C CN HS++CH+ DP F
Sbjct: 277 DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHF----DPAVF 332
Query: 596 EHFRGG-GGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSIL 654
+G GGVCD+C +T G+NCE C+ ++FR S + C C+CD G G+
Sbjct: 333 AASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGA-P 391
Query: 655 CDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQ 714
CD + GQC CK HV G +C+ C+ GF L +P GC C+CN G+ D+ C + SG+
Sbjct: 392 CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGS-RRDMPCDEESGR 450
Query: 715 CKCKANVIGLRCDHC-NFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAK 773
C C NV+G +CD C + +K + GCEPC C+ H S++ CN +GQC C++
Sbjct: 451 CLCLPNVVGPKCDQCAPYHWKLA---SGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFG 507
Query: 774 GLQCDT-----CRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNK 828
GL C C + YG T C+ACDCD G+ G C+ +G+C+C+P + G +C++
Sbjct: 508 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGT-EGPGCDKASGRCLCRPGLTGPRCDQ 566
Query: 829 CLEGNFYLRQNNSFLCLPC 847
C G + R C PC
Sbjct: 567 CQRG-YCNRYPVCVACHPC 584
Score = 179 bits (453), Expect = 8e-44
Identities = 110/336 (32%), Positives = 154/336 (45%), Gaps = 46/336 (13%)
Query: 647 GTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYN------LQELDPDGCSPCNCNTSG 700
G G Q+ C C+ + +G C +C FYN + D C C+CN
Sbjct: 264 GASAGPSTAVQVHDVCVCQHNTAGPNCERCAP-FYNNRPWRPAEGQDAHECQRCDCNGHS 322
Query: 701 TVDGDITCHQN-----------SGQC-KCKANVIGLRCDHCNFGFKFLR----SFNDVGC 744
TCH + G C C+ + G C+ C + R S + C
Sbjct: 323 E-----TCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQET-C 376
Query: 745 EPCQCNLHGSV-NKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTN---CKACDCDTA 800
C+C+ G+V C+P +GQC CK+ +G +CD C+ F GL N C CDC+
Sbjct: 377 ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNIL 436
Query: 801 GSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLL 860
GS C+ ++G+C+C PNV G +C++C ++ L C PC CD +++
Sbjct: 437 GSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQG--CEPCACDPHNSLSPQ-- 492
Query: 861 CNKSTGQCPCKLGVTGLRCN-----QCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDP 915
CN+ TGQCPC+ G GL C+ QC Y D C+ C+CD GT G CD
Sbjct: 493 CNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYG---DVATGCRACDCDFRGT-EGPGCDK 548
Query: 916 ISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPC 951
SG+CLC P G RC+QCQ G+ C PC
Sbjct: 549 ASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPC 584
Score = 177 bits (449), Expect = 2e-43
Identities = 107/325 (32%), Positives = 150/325 (46%), Gaps = 45/325 (13%)
Query: 749 CNLHGSVNKFCNPHSGQ-------------CECKKEAKGLQCDTCRENFY---------G 786
C HG ++ C P G C C+ G C+ C FY G
Sbjct: 250 CFCHGHADR-CAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAP-FYNNRPWRPAEG 307
Query: 787 LDVTNCKACDC----DTAGSLPGTVC---NAKTGQCI-CKPNVEGRQCNKCLEGNFYLRQ 838
D C+ CDC +T P A G C C+ + EG+ C +C F R+
Sbjct: 308 QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRR 367
Query: 839 NNSFL---CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQ 895
+ + C+ C CD G + G+ C+ TGQC CK V G RC+ C+P LT N Q
Sbjct: 368 PGASIQETCISCECDPDGAVPGAP-CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQ 426
Query: 896 HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHT 955
C C+C+ LG+ CD SG+CLC+PN G +C+QC P ++ + GC PC+C
Sbjct: 427 GCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDP 485
Query: 956 TGAVNHICNSLTGQCVCQDASIAGQRCD-----QCKDHYFGFDPQTGRCQPCNCHLSGAL 1010
+++ CN TGQC C++ G C QC D +G D TG C+ C+C G
Sbjct: 486 HNSLSPQCNQFTGQCPCRE-GFGGLMCSAAAIRQCPDRTYG-DVATG-CRACDCDFRGTE 542
Query: 1011 NETCHLVTGQCFCKQFVTGSKCDAC 1035
C +G+C C+ +TG +CD C
Sbjct: 543 GPGCDKASGRCLCRPGLTGPRCDQC 567
Score = 91.3 bits (225), Expect = 2e-17
Identities = 60/199 (30%), Positives = 90/199 (45%), Gaps = 39/199 (19%)
Query: 868 CPCKLGVTGLRCNQCEPHRYNLTI-----DNFQHCQMCECD---------------SLGT 907
C C+ G C +C P N + CQ C+C+ S G
Sbjct: 279 CVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGA 338
Query: 908 LPGTICDPISGQCLCVPNRQGRRCNQCQPGFYIS--PGNATG--CLPCSCHTTGAVNHI- 962
G +CD C + +G+ C +CQ ++ + PG + C+ C C GAV
Sbjct: 339 YGG-VCDN------CRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAP 391
Query: 963 CNSLTGQCVCQDASIAGQRCDQCKDHYFGF---DPQTGRCQPCNCHLSGALNET-CHLVT 1018
C+ +TGQCVC++ + G+RCD CK + G +PQ C C+C++ G+ + C +
Sbjct: 392 CDPVTGQCVCKE-HVQGERCDLCKPGFTGLTYANPQG--CHRCDCNILGSRRDMPCDEES 448
Query: 1019 GQCFCKQFVTGSKCDACVP 1037
G+C C V G KCD C P
Sbjct: 449 GRCLCLPNVVGPKCDQCAP 467
Score = 72.0 bits (175), Expect = 1e-11
Identities = 52/182 (28%), Positives = 73/182 (40%), Gaps = 40/182 (21%)
Query: 903 DSLGTLPGTICDP-----ISGQCLCVPNRQGRRCNQCQPGFYISPG------NATGCLPC 951
D PG P + C+C N G C +C P + P +A C C
Sbjct: 257 DRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRC 316
Query: 952 SCH---------------TTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYF-----G 991
C+ + GA +C++ C+D + G+ C++C+ HYF G
Sbjct: 317 DCNGHSETCHFDPAVFAASQGAYGGVCDN------CRDHT-EGKNCERCQLHYFRNRRPG 369
Query: 992 FDPQTGRCQPCNCHLSGAL-NETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050
Q C C C GA+ C VTGQC CK+ V G +CD C P + L N GC
Sbjct: 370 ASIQE-TCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGC 428
Query: 1051 SK 1052
+
Sbjct: 429 HR 430
>gi|189083719 laminin, beta 3 precursor [Homo sapiens]
Length = 1172
Score = 298 bits (762), Expect = 1e-79
Identities = 164/499 (32%), Positives = 253/499 (50%), Gaps = 38/499 (7%)
Query: 369 VTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC-GAFGMKNN 427
V++ +DL+ ++Q+ ++++F P P + I+R + W +QY A +C F
Sbjct: 104 VSLQLDLDR-RFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAADCTSTFPRVRQ 162
Query: 428 GDLEKPDSVNCLQLSNFTPYSR---GNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQ 484
G + V C L P +R G V +++ + +QE + T
Sbjct: 163 GRPQSWQDVRCQSLPQ-RPNARLNGGKVQLNLMDLVSGIPATQSQ-----KIQEVGEITN 216
Query: 485 IRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNC---------DTTSQPYR 535
+R +F + + YYAV ++ + G C CHGHAD C +T+
Sbjct: 217 LRVNFTRLAPVPQRGYHPPSAYYAVSQLRLQGSCFCHGHADRCAPKPGASAGPSTAVQVH 276
Query: 536 CLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPF 595
+C + T G +C+RC P YN++P+R + A C+ C CN HS++CH+ DP F
Sbjct: 277 DVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHF----DPAVF 332
Query: 596 EHFRGG-GGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSIL 654
+G GGVCD+C +T G+NCE C+ ++FR S + C C+CD G G+
Sbjct: 333 AASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGA-P 391
Query: 655 CDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQ 714
CD + GQC CK HV G +C+ C+ GF L +P GC C+CN G+ D+ C + SG+
Sbjct: 392 CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNILGS-RRDMPCDEESGR 450
Query: 715 CKCKANVIGLRCDHC-NFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAK 773
C C NV+G +CD C + +K + GCEPC C+ H S++ CN +GQC C++
Sbjct: 451 CLCLPNVVGPKCDQCAPYHWKLA---SGQGCEPCACDPHNSLSPQCNQFTGQCPCREGFG 507
Query: 774 GLQCDT-----CRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNK 828
GL C C + YG T C+ACDCD G+ G C+ +G+C+C+P + G +C++
Sbjct: 508 GLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGT-EGPGCDKASGRCLCRPGLTGPRCDQ 566
Query: 829 CLEGNFYLRQNNSFLCLPC 847
C G + R C PC
Sbjct: 567 CQRG-YCNRYPVCVACHPC 584
Score = 179 bits (453), Expect = 8e-44
Identities = 110/336 (32%), Positives = 154/336 (45%), Gaps = 46/336 (13%)
Query: 647 GTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYN------LQELDPDGCSPCNCNTSG 700
G G Q+ C C+ + +G C +C FYN + D C C+CN
Sbjct: 264 GASAGPSTAVQVHDVCVCQHNTAGPNCERCAP-FYNNRPWRPAEGQDAHECQRCDCNGHS 322
Query: 701 TVDGDITCHQN-----------SGQC-KCKANVIGLRCDHCNFGFKFLR----SFNDVGC 744
TCH + G C C+ + G C+ C + R S + C
Sbjct: 323 E-----TCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQET-C 376
Query: 745 EPCQCNLHGSV-NKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTN---CKACDCDTA 800
C+C+ G+V C+P +GQC CK+ +G +CD C+ F GL N C CDC+
Sbjct: 377 ISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNIL 436
Query: 801 GSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLL 860
GS C+ ++G+C+C PNV G +C++C ++ L C PC CD +++
Sbjct: 437 GSRRDMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQG--CEPCACDPHNSLSPQ-- 492
Query: 861 CNKSTGQCPCKLGVTGLRCN-----QCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDP 915
CN+ TGQCPC+ G GL C+ QC Y D C+ C+CD GT G CD
Sbjct: 493 CNQFTGQCPCREGFGGLMCSAAAIRQCPDRTYG---DVATGCRACDCDFRGT-EGPGCDK 548
Query: 916 ISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPC 951
SG+CLC P G RC+QCQ G+ C PC
Sbjct: 549 ASGRCLCRPGLTGPRCDQCQRGYCNRYPVCVACHPC 584
Score = 177 bits (449), Expect = 2e-43
Identities = 107/325 (32%), Positives = 150/325 (46%), Gaps = 45/325 (13%)
Query: 749 CNLHGSVNKFCNPHSGQ-------------CECKKEAKGLQCDTCRENFY---------G 786
C HG ++ C P G C C+ G C+ C FY G
Sbjct: 250 CFCHGHADR-CAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAP-FYNNRPWRPAEG 307
Query: 787 LDVTNCKACDC----DTAGSLPGTVC---NAKTGQCI-CKPNVEGRQCNKCLEGNFYLRQ 838
D C+ CDC +T P A G C C+ + EG+ C +C F R+
Sbjct: 308 QDAHECQRCDCNGHSETCHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRR 367
Query: 839 NNSFL---CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQ 895
+ + C+ C CD G + G+ C+ TGQC CK V G RC+ C+P LT N Q
Sbjct: 368 PGASIQETCISCECDPDGAVPGAP-CDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQ 426
Query: 896 HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHT 955
C C+C+ LG+ CD SG+CLC+PN G +C+QC P ++ + GC PC+C
Sbjct: 427 GCHRCDCNILGSRRDMPCDEESGRCLCLPNVVGPKCDQCAP-YHWKLASGQGCEPCACDP 485
Query: 956 TGAVNHICNSLTGQCVCQDASIAGQRCD-----QCKDHYFGFDPQTGRCQPCNCHLSGAL 1010
+++ CN TGQC C++ G C QC D +G D TG C+ C+C G
Sbjct: 486 HNSLSPQCNQFTGQCPCRE-GFGGLMCSAAAIRQCPDRTYG-DVATG-CRACDCDFRGTE 542
Query: 1011 NETCHLVTGQCFCKQFVTGSKCDAC 1035
C +G+C C+ +TG +CD C
Sbjct: 543 GPGCDKASGRCLCRPGLTGPRCDQC 567
Score = 91.3 bits (225), Expect = 2e-17
Identities = 60/199 (30%), Positives = 90/199 (45%), Gaps = 39/199 (19%)
Query: 868 CPCKLGVTGLRCNQCEPHRYNLTI-----DNFQHCQMCECD---------------SLGT 907
C C+ G C +C P N + CQ C+C+ S G
Sbjct: 279 CVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSETCHFDPAVFAASQGA 338
Query: 908 LPGTICDPISGQCLCVPNRQGRRCNQCQPGFYIS--PGNATG--CLPCSCHTTGAVNHI- 962
G +CD C + +G+ C +CQ ++ + PG + C+ C C GAV
Sbjct: 339 YGG-VCDN------CRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPDGAVPGAP 391
Query: 963 CNSLTGQCVCQDASIAGQRCDQCKDHYFGF---DPQTGRCQPCNCHLSGALNET-CHLVT 1018
C+ +TGQCVC++ + G+RCD CK + G +PQ C C+C++ G+ + C +
Sbjct: 392 CDPVTGQCVCKE-HVQGERCDLCKPGFTGLTYANPQG--CHRCDCNILGSRRDMPCDEES 448
Query: 1019 GQCFCKQFVTGSKCDACVP 1037
G+C C V G KCD C P
Sbjct: 449 GRCLCLPNVVGPKCDQCAP 467
Score = 72.0 bits (175), Expect = 1e-11
Identities = 52/182 (28%), Positives = 73/182 (40%), Gaps = 40/182 (21%)
Query: 903 DSLGTLPGTICDP-----ISGQCLCVPNRQGRRCNQCQPGFYISPG------NATGCLPC 951
D PG P + C+C N G C +C P + P +A C C
Sbjct: 257 DRCAPKPGASAGPSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRC 316
Query: 952 SCH---------------TTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYF-----G 991
C+ + GA +C++ C+D + G+ C++C+ HYF G
Sbjct: 317 DCNGHSETCHFDPAVFAASQGAYGGVCDN------CRDHT-EGKNCERCQLHYFRNRRPG 369
Query: 992 FDPQTGRCQPCNCHLSGAL-NETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050
Q C C C GA+ C VTGQC CK+ V G +CD C P + L N GC
Sbjct: 370 ASIQE-TCISCECDPDGAVPGAPCDPVTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGC 428
Query: 1051 SK 1052
+
Sbjct: 429 HR 430
>gi|167614504 laminin, beta 1 precursor [Homo sapiens]
Length = 1786
Score = 277 bits (708), Expect = 2e-73
Identities = 162/482 (33%), Positives = 240/482 (49%), Gaps = 53/482 (10%)
Query: 335 LNPEAHPLSFVNDNDVGTSWVSNVFTNITQLNQGV---TISVDLENGQYQVFYIIIQFFS 391
LNP++H + +V T++ N Q GV TI +DLE ++ ++I+ F +
Sbjct: 89 LNPDSHLIE-----NVVTTFAPNRLKIWWQSENGVENVTIQLDLE-AEFHFTHLIMTFKT 142
Query: 392 PQPTEIRIQRKKENSLDWEDWQYFARNCGA-FGMKNNGDLEKPDSVNC-LQLSNFTPYSR 449
+P + I+R + W ++YFA +C A F + G ++K D + C + S+ P +
Sbjct: 143 FRPAAMLIERSSDFGKTWGVYRYFAYDCEASFPGISTGPMKKVDDIICDSRYSDIEPSTE 202
Query: 450 GNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVNLRHR---- 505
G V F L P Y+ P +Q +K T +R F + + ++ R
Sbjct: 203 GEVIFRALDPAFKIEDPYS-----PRIQNLLKITNLRIKFVKLHTLGDNLLDSRMEIREK 257
Query: 506 -YYAVDEITISGRCQCHGHADNC---DTTSQPYR------CLCSQESFTEGLHCDRCLPL 555
YYAV ++ + G C C+GHA C D ++ C+C T+GL+C+ C+
Sbjct: 258 YYYAVYDMVVRGNCFCYGHASECAPVDGFNEEVEGMVHGHCMCRHN--TKGLNCELCMDF 315
Query: 556 YNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGR 615
Y+D P+R + + CK C CN HS SCH++++V GGVCDDC+HNT GR
Sbjct: 316 YHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVY---LATGNVSGGVCDDCQHNTMGR 372
Query: 616 NCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQ--------IGGQCNCKRH 667
NCE CK ++++ D + C+ C CD G++N I CD I GQC CK +
Sbjct: 373 NCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGI-CDSYTDFSTGLIAGQCRCKLN 431
Query: 668 VSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCD 727
V G C+ C+ GFY+L DP GC C CN GT+ G C +G C CK V G CD
Sbjct: 432 VEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSETGHCYCKRLVTGQHCD 491
Query: 728 HC---NFGFKFLRSFNDV-GCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCREN 783
C ++G ND+ GC PC C+L G++N C SGQC C+ G QC+
Sbjct: 492 QCLPEHWGLS-----NDLDGCRPCDCDLGGALNNSCFAESGQCSCRPHMIGRQCNEVEPG 546
Query: 784 FY 785
+Y
Sbjct: 547 YY 548
Score = 240 bits (613), Expect = 2e-62
Identities = 138/417 (33%), Positives = 194/417 (46%), Gaps = 46/417 (11%)
Query: 641 CDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSG 700
C+CD G+ S +CD GGQC C+ +V GR CN+C G + P GC PC C+ G
Sbjct: 773 CECDPQGSL--SSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGF---GPSGCKPCECHLQG 827
Query: 701 TVDGDITCHQNSGQCKCKANVIGLRCDHC---NFGFKFLRSFNDVGCEPCQCNLHGSVNK 757
+V+ C+ +GQC C V +CD C ++GF C+PCQCN H
Sbjct: 828 SVNA--FCNPVTGQCHCFQGVYARQCDRCLPGHWGFP--------SCQPCQCNGHADD-- 875
Query: 758 FCNPHSGQC-ECKKEAKGLQCDTCRENFYGLDVT----NCKACDCDT---AGSLPGTVC- 808
C+P +G+C C+ G C+ C +YG + +C+ C C +G C
Sbjct: 876 -CDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCY 934
Query: 809 -NAKTGQ--CICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKST 865
+ T Q C+C P G +C+ C G F C PC C C+K T
Sbjct: 935 QDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKET 994
Query: 866 GQC-PCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI------CDPISG 918
G+C C G C C Y + Q C+ C C+ LGT+ CD +G
Sbjct: 995 GRCLKCLYHTEGEHCQFCRFGYYGDALQ--QDCRKCVCNYLGTVQEHCNGSDCQCDKATG 1052
Query: 919 QCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIA 978
QCLC+PN G+ C++C P + + TGC PC+C+ + CN TGQC C
Sbjct: 1053 QCLCLPNVIGQNCDRCAPNTW-QLASGTGCDPCNCNAAHSFGPSCNEFTGQCQCMPG-FG 1110
Query: 979 GQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDAC 1035
G+ C +C++ ++G DP C+ C+C G C TGQC C + V G +CD C
Sbjct: 1111 GRTCSECQELFWG-DPDV-ECRACDCDPRGIETPQCDQSTGQCVCVEGVEGPRCDKC 1165
Score = 202 bits (514), Expect = 7e-51
Identities = 162/562 (28%), Positives = 231/562 (41%), Gaps = 89/562 (15%)
Query: 479 FVKATQIRFHFHGQYYTTETAVNLRHRYYAVDEITISGRCQC------HGHADNCDTTS- 531
F K T YT+ + ++ Y +D + + C+ G D T S
Sbjct: 672 FEKGTNYTVRLELPQYTSSDS-DVESPYTLIDSLVLMPYCKSLDIFTVGGSGDGVVTNSA 730
Query: 532 ----QPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYN 587
Q YRCL + S + D C + A C P S S C N
Sbjct: 731 WETFQRYRCLENSRSVVKTPMTDVCRNIIFSISALLHQTGLACECDPQ--GSLSSVCDPN 788
Query: 588 ISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVG 647
GG C C N GR C C F G PS CKPC+C G
Sbjct: 789 --------------GGQCQ-CRPNVVGRTCNRCAPGTF---GFGPSG---CKPCECHLQG 827
Query: 648 TRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDIT 707
+ N C+ + GQC+C + V RQC++C G + C PC CN G D
Sbjct: 828 SVNA--FCNPVTGQCHCFQGVYARQCDRCLPGHWGFPS-----CQPCQCN--GHADD--- 875
Query: 708 CHQNSGQC-KCKANVIGLRCDHCNFGFKFLRSFND--VG----CEPCQC------NLHGS 754
C +G+C C+ +G C+ C G+ + D +G C PC C +
Sbjct: 876 CDPVTGECLNCQDYTMGHNCERCLAGY-----YGDPIIGSGDHCRPCPCPDGPDSGRQFA 930
Query: 755 VNKFCNPHSGQ--CECKKEAKGLQCDTCRENFYGLDVT---NCKACDC-DTAGSLPGTVC 808
+ + +P + Q C C G +CD C ++G +C+ C C + + C
Sbjct: 931 RSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEAC 990
Query: 809 NAKTGQCI-CKPNVEGRQCNKCLEGNF--YLRQNNSFLCLPCNCDKTGTI----NGS-LL 860
+ +TG+C+ C + EG C C G + L+Q+ C C C+ GT+ NGS
Sbjct: 991 DKETGRCLKCLYHTEGEHCQFCRFGYYGDALQQD----CRKCVCNYLGTVQEHCNGSDCQ 1046
Query: 861 CNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQC 920
C+K+TGQC C V G C++C P+ + L C C C++ + G C+ +GQC
Sbjct: 1047 CDKATGQCLCLPNVIGQNCDRCAPNTWQLASGT--GCDPCNCNAAHSF-GPSCNEFTGQC 1103
Query: 921 LCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQ 980
C+P GR C++CQ F+ P C C C G C+ TGQCVC + + G
Sbjct: 1104 QCMPGFGGRTCSECQELFWGDPD--VECRACDCDPRGIETPQCDQSTGQCVCVEG-VEGP 1160
Query: 981 RCDQCKDHYFGFDPQTGRCQPC 1002
RCD+C Y G P C C
Sbjct: 1161 RCDKCTRGYSGVFPDCTPCHQC 1182
Score = 172 bits (437), Expect = 6e-42
Identities = 100/315 (31%), Positives = 143/315 (45%), Gaps = 31/315 (9%)
Query: 747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGT 806
C+C+ GS++ C+P+ GQC+C+ G C+ C +G + CK C+C GS+
Sbjct: 773 CECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNRCAPGTFGFGPSGCKPCECHLQGSV-NA 831
Query: 807 VCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTG 866
CN TGQC C V RQC++CL G++ C PC C+ C+ TG
Sbjct: 832 FCNPVTGQCHCFQGVYARQCDRCLPGHWGFPS-----CQPCQCNGHADD-----CDPVTG 881
Query: 867 QC-PCKLGVTGLRCNQCEPHRY-NLTIDNFQHCQMCECDS---LGTLPGTIC--DPISGQ 919
+C C+ G C +C Y + I + HC+ C C G C DP++ Q
Sbjct: 882 ECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDSGRQFARSCYQDPVTLQ 941
Query: 920 --CLCVPNRQGRRCNQCQPGFYISPGNATG-CLPCSCHTTGAVN--HICNSLTGQCVCQD 974
C+C P G RC+ C G++ +P G C PC CH C+ TG+C+
Sbjct: 942 LACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTTDPEACDKETGRCLKCL 1001
Query: 975 ASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCH-------LVTGQCFCKQFV 1027
G+ C C+ Y+G D C+ C C+ G + E C+ TGQC C V
Sbjct: 1002 YHTEGEHCQFCRFGYYG-DALQQDCRKCVCNYLGTVQEHCNGSDCQCDKATGQCLCLPNV 1060
Query: 1028 TGSKCDACVPSASHL 1042
G CD C P+ L
Sbjct: 1061 IGQNCDRCAPNTWQL 1075
Score = 160 bits (404), Expect = 4e-38
Identities = 90/257 (35%), Positives = 122/257 (47%), Gaps = 30/257 (11%)
Query: 713 GQCKCKANVIGLRCDHC-----NFGFKFLRSFNDVGCEPCQCNLHGSVNKFC-------- 759
G C C+ N GL C+ C + ++ N C+ C CN H F
Sbjct: 296 GHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLATG 355
Query: 760 NPHSGQCE-CKKEAKGLQCDTCRENFYG------LDVTNCKACDCDTAGSLPGTVCNAKT 812
N G C+ C+ G C+ C+ +Y D C+ C CD AGS +C++ T
Sbjct: 356 NVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICDSYT 415
Query: 813 --------GQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKS 864
GQC CK NVEG C+ C EG + L + F C C C+ GTI G C+
Sbjct: 416 DFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGTIPGGNPCDSE 475
Query: 865 TGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVP 924
TG C CK VTG C+QC P + L+ D C+ C+CD G L + C SGQC C P
Sbjct: 476 TGHCYCKRLVTGQHCDQCLPEHWGLSND-LDGCRPCDCDLGGALNNS-CFAESGQCSCRP 533
Query: 925 NRQGRRCNQCQPGFYIS 941
+ GR+CN+ +PG+Y +
Sbjct: 534 HMIGRQCNEVEPGYYFA 550
Score = 153 bits (387), Expect = 4e-36
Identities = 88/271 (32%), Positives = 134/271 (49%), Gaps = 43/271 (15%)
Query: 658 IGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDG-----CSPCNCNTSGTVDGDITCH--- 709
+ G C C+ + G C C + +++L +G C CNCN + I+CH
Sbjct: 294 VHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCN-----EHSISCHFDM 348
Query: 710 --------QNSGQCK-CKANVIGLRCDHCNFGFKFLRSFNDVG----CEPCQCNLHGSVN 756
+ G C C+ N +G C+ C F + D+ CE C C+ GS N
Sbjct: 349 AVYLATGNVSGGVCDDCQHNTMGRNCEQCK-PFYYQHPERDIRDPNFCERCTCDPAGSQN 407
Query: 757 K-FCNPHS--------GQCECKKEAKGLQCDTCRENFYGL---DVTNCKACDCDTAGSLP 804
+ C+ ++ GQC CK +G CD C+E FY L D CK+C C+ G++P
Sbjct: 408 EGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGTIP 467
Query: 805 G-TVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNK 863
G C+++TG C CK V G+ C++CL ++ L N+ C PC+CD G +N S C
Sbjct: 468 GGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGL-SNDLDGCRPCDCDLGGALNNS--CFA 524
Query: 864 STGQCPCKLGVTGLRCNQCEPHRYNLTIDNF 894
+GQC C+ + G +CN+ EP Y T+D++
Sbjct: 525 ESGQCSCRPHMIGRQCNEVEPGYYFATLDHY 555
Score = 148 bits (374), Expect = 1e-34
Identities = 85/258 (32%), Positives = 121/258 (46%), Gaps = 41/258 (15%)
Query: 813 GQCICKPNVEGRQCNKCLEGNFY-------LRQNNSFLCLPCNCDKTGTINGSLLC---- 861
G C+C+ N +G C C++ FY NS C CNC++ S+ C
Sbjct: 296 GHCMCRHNTKGLNCELCMD--FYHDLPWRPAEGRNSNACKKCNCNEH-----SISCHFDM 348
Query: 862 -------NKSTGQCP-CKLGVTGLRCNQCEPHRYN---LTIDNFQHCQMCECDSLGTLPG 910
N S G C C+ G C QC+P Y I + C+ C CD G+
Sbjct: 349 AVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNE 408
Query: 911 TICDP--------ISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAV-- 959
ICD I+GQC C N +G C+ C+ GFY +S + GC C+C+ G +
Sbjct: 409 GICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGTIPG 468
Query: 960 NHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTG 1019
+ C+S TG C C+ + GQ CDQC ++G C+PC+C L GALN +C +G
Sbjct: 469 GNPCDSETGHCYCKRL-VTGQHCDQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCFAESG 527
Query: 1020 QCFCKQFVTGSKCDACVP 1037
QC C+ + G +C+ P
Sbjct: 528 QCSCRPHMIGRQCNEVEP 545
Score = 137 bits (344), Expect = 4e-31
Identities = 80/263 (30%), Positives = 123/263 (46%), Gaps = 46/263 (17%)
Query: 764 GQCECKKEAKGLQCDTCRENFY--------GLDVTNCKACDCD--------------TAG 801
G C C+ KGL C+ C + ++ G + CK C+C+ G
Sbjct: 296 GHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLATG 355
Query: 802 SLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQ-----NNSFLCLPCNCDKTGTIN 856
++ G VC+ C+ N GR C +C FY + + C C CD G+ N
Sbjct: 356 NVSGGVCDD------CQHNTMGRNCEQCKP--FYYQHPERDIRDPNFCERCTCDPAGSQN 407
Query: 857 GSLLCNKST--------GQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTL 908
+ C+ T GQC CKL V G C+ C+ Y+L+ ++ C+ C C+ LGT+
Sbjct: 408 EGI-CDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPLGTI 466
Query: 909 PG-TICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLT 967
PG CD +G C C G+ C+QC P + + GC PC C GA+N+ C + +
Sbjct: 467 PGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCFAES 526
Query: 968 GQCVCQDASIAGQRCDQCKDHYF 990
GQC C+ I G++C++ + Y+
Sbjct: 527 GQCSCRPHMI-GRQCNEVEPGYY 548
Score = 87.4 bits (215), Expect = 3e-16
Identities = 37/89 (41%), Positives = 54/89 (60%), Gaps = 3/89 (3%)
Query: 949 LPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSG 1008
L C C G+++ +C+ GQC C+ ++ G+ C++C FGF P C+PC CHL G
Sbjct: 771 LACECDPQGSLSSVCDPNGGQCQCRP-NVVGRTCNRCAPGTFGFGPSG--CKPCECHLQG 827
Query: 1009 ALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
++N C+ VTGQC C Q V +CD C+P
Sbjct: 828 SVNAFCNPVTGQCHCFQGVYARQCDRCLP 856
Score = 69.7 bits (169), Expect = 7e-11
Identities = 47/163 (28%), Positives = 67/163 (41%), Gaps = 29/163 (17%)
Query: 916 ISGQCLCVPNRQGRRCNQCQPGFYISPG------NATGCLPC-------SCHTTGAVNHI 962
+ G C+C N +G C C ++ P N+ C C SCH AV
Sbjct: 294 VHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSISCHFDMAVYLA 353
Query: 963 CNSLTGQCVCQDA--SIAGQRCDQCKDHYFGFDPQTGR----CQPCNCHLSGALNE---- 1012
+++G VC D + G+ C+QCK Y+ + R C+ C C +G+ NE
Sbjct: 354 TGNVSGG-VCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPAGSQNEGICD 412
Query: 1013 -----TCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050
+ L+ GQC CK V G CD C L + GC
Sbjct: 413 SYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGC 455
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 275 bits (704), Expect = 7e-73
Identities = 171/471 (36%), Positives = 229/471 (48%), Gaps = 52/471 (11%)
Query: 604 VCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC- 662
VC C TG +CE C R G I C+PC C + CD + G+C
Sbjct: 723 VCQ-CPPGYTGSSCESCWPRHRRVNGTIFGGI--CEPCQCF-----GHAESCDDVTGECL 774
Query: 663 NCKRHVSGRQCNQCQNGFYNLQELDP-DGCSPCNCNTSGTVDG-DITCHQNSGQ---CK- 716
NCK H G C++C GFY + C PC C + + TCH + C
Sbjct: 775 NCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDG 834
Query: 717 CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCN--LHGSVNKFCNPHSGQCE-CKKEAK 773
C G RC+ C G+ S C+PCQCN L S+ C+ SG C CK
Sbjct: 835 CPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTT 894
Query: 774 GLQCDTCRENFYG--LDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLE 831
G C+ C + ++G +D NC+ C C+ GS VC+++TGQC C+ NV+G++C+KC
Sbjct: 895 GRYCELCADGYFGDAVDAKNCQPCRCNAGGSF-SEVCHSQTGQCECRANVQGQRCDKCKA 953
Query: 832 GNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTI 891
G F L+ C+PCNC+ G+ S C +S GQC C+ GVTG +C++C H Y
Sbjct: 954 GTFGLQSARG--CVPCNCNSFGS--KSFDCEES-GQCWCQPGVTGKKCDRCA-HGYF--- 1004
Query: 892 DNFQH--CQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCL 949
NFQ C CEC LG CDP +G+C+C PN G +C++C P + TGC
Sbjct: 1005 -NFQEGGCTACECSHLGNN----CDPKTGRCICPPNTIGEKCSKCAPNTW-GHSITTGCK 1058
Query: 950 PCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGA 1009
C+C T G+++ CN TGQC C +G +C +C ++ + RC C+C L G
Sbjct: 1059 ACNCSTVGSLDFQCNVNTGQCNCHP-KFSGAKCTECSRGHWNYP----RCNLCDCFLPGT 1113
Query: 1010 LNETCHLVT---------GQCFCKQFVTGSKCDACVPSASHLDVNNLLGCS 1051
TC T GQC CK V G CD C P LD N LGCS
Sbjct: 1114 DATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCS 1164
Score = 273 bits (699), Expect = 2e-72
Identities = 154/456 (33%), Positives = 218/456 (47%), Gaps = 58/456 (12%)
Query: 518 CQCHGHADNC-DTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQ 576
CQC GHA++C D T + C + T G +CD+CLP + +P + + +C+PC
Sbjct: 757 CQCFGHAESCDDVTGECLNC----KDHTGGPYCDKCLPGFYGEPTKGTSE----DCQPCA 808
Query: 577 C------NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGA 630
C N+ S +CH + S+ G +CD C TG CE C + +F Q
Sbjct: 809 CPLNIPSNNFSPTCHLDRSL-----------GLICDGCPVGYTGPRCERCAEGYFGQPSV 857
Query: 631 DPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC-NCKRHVSGRQCNQCQNGFYNLQELDPD 689
+ C+PC C+ + CD + G C CK +GR C C +G++ +D
Sbjct: 858 PGGS---CQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFG-DAVDAK 913
Query: 690 GCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQC 749
C PC CN G+ CH +GQC+C+ANV G RCD C G L+S GC PC C
Sbjct: 914 NCQPCRCNAGGSFSE--VCHSQTGQCECRANVQGQRCDKCKAGTFGLQSAR--GCVPCNC 969
Query: 750 NLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCN 809
N GS + C SGQC C+ G +CD C ++ C AC+C S G C+
Sbjct: 970 NSFGSKSFDCE-ESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACEC----SHLGNNCD 1024
Query: 810 AKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCP 869
KTG+CIC PN G +C+KC + + + C CNC G+++ CN +TGQC
Sbjct: 1025 PKTGRCICPPNTIGEKCSKCAPNTW--GHSITTGCKACNCSTVGSLD--FQCNVNTGQCN 1080
Query: 870 CKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI--------CDPISGQCL 921
C +G +C +C + N+ C +C+C GT T C +GQC
Sbjct: 1081 CHPKFSGAKCTECSRGHW-----NYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCT 1135
Query: 922 CVPNRQGRRCNQCQPG-FYISPGNATGCLPCSCHTT 956
C N +G C++C+PG F + N GC C C T
Sbjct: 1136 CKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGT 1171
Score = 235 bits (600), Expect = 8e-61
Identities = 138/475 (29%), Positives = 216/475 (45%), Gaps = 54/475 (11%)
Query: 546 GLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVC 605
G C+ C P + R ++ C+PCQC H++SC G C
Sbjct: 732 GSSCESCWPRHR----RVNGTIFGGICEPCQCFGHAESCD--------------DVTGEC 773
Query: 606 DDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCD-TVGTRNGSILCD---QIGGQ 661
+C+ +T G C+ C F+ + S + C+PC C + + N S C +G
Sbjct: 774 LNCKDHTGGPYCDKCLPGFYGEPTKGTS--EDCQPCACPLNIPSNNFSPTCHLDRSLGLI 831
Query: 662 CN-CKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCK-CKA 719
C+ C +G +C +C G++ + C PC CN + +C SG C CK
Sbjct: 832 CDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKP 891
Query: 720 NVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDT 779
G C+ C G+ F + + C+PC+CN GS ++ C+ +GQCEC+ +G +CD
Sbjct: 892 GTTGRYCELCADGY-FGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK 950
Query: 780 CRENFYGL-DVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQ 838
C+ +GL C C+C++ GS C ++GQC C+P V G++C++C G F ++
Sbjct: 951 CKAGTFGLQSARGCVPCNCNSFGS-KSFDCE-ESGQCWCQPGVTGKKCDRCAHGYFNFQE 1008
Query: 839 NNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQ 898
C C C G C+ TG+C C G +C++C P+ + +I C+
Sbjct: 1009 GG---CTACECSHLGN-----NCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITT--GCK 1058
Query: 899 MCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGA 958
C C ++G+L C+ +GQC C P G +C +C G + N C C C G
Sbjct: 1059 ACNCSTVGSLDFQ-CNVNTGQCNCHPKFSGAKCTECSRGHW----NYPRCNLCDCFLPGT 1113
Query: 959 VNHICNSLTGQCVCQD--------ASIAGQRCDQCKDHYFGFDPQTG-RCQPCNC 1004
C+S T +C C D ++ G CD+C+ FG D + C C C
Sbjct: 1114 DATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYC 1168
Score = 194 bits (492), Expect = 3e-48
Identities = 138/449 (30%), Positives = 205/449 (45%), Gaps = 53/449 (11%)
Query: 336 NP-EAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTISVDLENGQYQVFYIIIQFF-SPQ 393
NP + HP++ D T W S N + + VTI++DL+ +Q+ Y+I++ SP+
Sbjct: 92 NPNQRHPITNAIDGK-NTWWQSPSIKNGIEYHY-VTITLDLQQ-VFQIAYVIVKAANSPR 148
Query: 394 PTEIRIQRKKENSLDWEDWQYFA---RNC----GAFGMKNNGDLEKPDSVNCLQL-SNFT 445
P ++R ++ ++++ WQY A C + K D V C S
Sbjct: 149 PGNWILERSLDD-VEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIH 207
Query: 446 PYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVNLRHR 505
P G + S++ N RP ++ +P L EF A IR F + H+
Sbjct: 208 PLENGEIHISLI----NGRPSADD--PSPELLEFTSARYIRLRFQRIRTLNADLMMFAHK 261
Query: 506 -------------YYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRC 552
YY+V +I++ G C C+GHA C + C E T G CD+C
Sbjct: 262 DPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQC 321
Query: 553 LPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFE-HFRG---GGGVCDDC 608
P ++ KP+R G + C+ C C+ ++ C+Y+ +V + RG GGGVC +C
Sbjct: 322 CPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINC 381
Query: 609 EHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQ-------IGGQ 661
NT G NCE C D FFR G P+ C+PC CD +G+ N + D+ G
Sbjct: 382 TQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGS 441
Query: 662 CNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANV 721
C+CK G C++C G+ PD C CNC+ G+ + D C G C CK NV
Sbjct: 442 CHCKTGFGGVSCDRCARGYTGY----PD-CKACNCSGLGSKNED-PCF---GPCICKENV 492
Query: 722 IGLRCDHCNFGFKFLRSFNDVGCEPCQCN 750
G C C GF L+ N GC+ C C+
Sbjct: 493 EGGDCSRCKSGFFNLQEDNWKGCDECFCS 521
Score = 124 bits (312), Expect = 2e-27
Identities = 86/289 (29%), Positives = 122/289 (42%), Gaps = 39/289 (13%)
Query: 785 YGLD-VTNCKACDCDTAGSLP--GTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNS 841
+G+D + + + ++A S P G++ A C C P G C C + R N +
Sbjct: 692 FGMDAIFRLSSVNLESAVSYPTDGSIA-AAVEVCQCPPGYTGSSCESCWPR--HRRVNGT 748
Query: 842 F---LCLPCNCDKTGTINGSLLCNKSTGQC-PCKLGVTGLRCNQCEPHRYNL-TIDNFQH 896
+C PC C + C+ TG+C CK G C++C P Y T +
Sbjct: 749 IFGGICEPCQC-----FGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSED 803
Query: 897 CQMCECD------------SLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGN 944
CQ C C L G ICD C G RC +C G++ P
Sbjct: 804 CQPCACPLNIPSNNFSPTCHLDRSLGLICDG------CPVGYTGPRCERCAEGYFGQPSV 857
Query: 945 ATG-CLPCSCHTT--GAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQP 1001
G C PC C+ ++ C+SL+G C+ G+ C+ C D YFG CQP
Sbjct: 858 PGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQP 917
Query: 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050
C C+ G+ +E CH TGQC C+ V G +CD C A + + GC
Sbjct: 918 CRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKC--KAGTFGLQSARGC 964
Score = 106 bits (264), Expect = 7e-22
Identities = 70/223 (31%), Positives = 94/223 (42%), Gaps = 42/223 (18%)
Query: 661 QCNCKRHVSGRQCNQCQNGFYNLQE-----LDPDGCSPCNC----------------NTS 699
+C C+ + G C+QC GF+ L C CNC N S
Sbjct: 306 RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLS 365
Query: 700 GTVDGDITCHQNSGQC-KCKANVIGLRCDHCNFGF---KFLRSFNDVGCEPCQCNLHGSV 755
+ G + G C C N G+ C+ C GF K + C+PC C+ GS+
Sbjct: 366 LNIRGK---YIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSL 422
Query: 756 NKFC---NPHS------GQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGT 806
N+ C H+ G C CK G+ CD C + G +CKAC+C GS
Sbjct: 423 NEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYP--DCKACNCSGLGSKNED 480
Query: 807 VCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNC 849
C G CICK NVEG C++C G F L+++N C C C
Sbjct: 481 PC---FGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
Score = 94.0 bits (232), Expect = 4e-18
Identities = 70/251 (27%), Positives = 102/251 (40%), Gaps = 51/251 (20%)
Query: 749 CNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYG--------LDVTNCKACDC--- 797
C L + NK +CEC+ G CD C F+ L T C+AC+C
Sbjct: 296 CPLDPATNK------SRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGK 349
Query: 798 ------DTAGSLPGTVCNAKT-----GQCI-CKPNVEGRQCNKCLEGNFY---LRQNNSF 842
D + N + G CI C N G C C +G F + N
Sbjct: 350 AEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPR 409
Query: 843 LCLPCNCDKTGTINGSLLCNK-------STGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQ 895
C PC+CD G++N + ++ + G C CK G G+ C++C +
Sbjct: 410 PCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARG-----YTGYP 464
Query: 896 HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCH 954
C+ C C LG+ DP G C+C N +G C++C+ GF+ + N GC C C
Sbjct: 465 DCKACNCSGLGSKNE---DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC- 520
Query: 955 TTGAVNHICNS 965
V++ C S
Sbjct: 521 --SGVSNRCQS 529
Score = 94.0 bits (232), Expect = 4e-18
Identities = 93/337 (27%), Positives = 149/337 (44%), Gaps = 38/337 (11%)
Query: 1544 IKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYS 1603
I+ RT+ GL+ + A N ++ +QL+ G YF +D + +
Sbjct: 2785 IELEVRTEAESGLLFYMARI-NHADFATVQLRNGLPYFSYDLGSGDTHTMIPT----KIN 2839
Query: 1604 DGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTG-VFLGGLPRSYTILRKDP 1662
DG+WH+I +R + G + +DG + I I D G +++GGLP +YT R P
Sbjct: 2840 DGQWHKIKIMRSKQEGILYVDG--ASNRTISPKKADILDVVGMLYVGGLPINYTTRRIGP 2897
Query: 1663 EIIQKGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGA 1722
+ GC++++H + P D + +V C A+ G F G
Sbjct: 2898 --VTYSIDGCVRNLHMAE--------APADLEQPTSSFHVGT----CFANAQRGTYFDGT 2943
Query: 1723 GFLELHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRL-NTS 1781
GF + F G++ + F+FRT G+LL + + D + +E+ L F + N +
Sbjct: 2944 GFAKA-VGGFKVGLDLLVEFEFRTTTTTGVLLGI-SSQKMDGMGIEMIDEKLMFHVDNGA 3001
Query: 1782 LAFTQV-DLLLGLSYCNGKWNKVIIKKEGSFISASVNGLM------KHASESGDQPLVVN 1834
FT V D + C+G+W+KV K I +V+G AS S D N
Sbjct: 3002 GRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSAD----TN 3057
Query: 1835 SPVYVGGIPQELLNSYQHLCLEQGFGGCMKDVKFTRG 1871
PV+VGG P +L L F GC++ +K T+G
Sbjct: 3058 DPVFVGGFPDDL--KQFGLTTSIPFRGCIRSLKLTKG 3092
Score = 92.0 bits (227), Expect = 1e-17
Identities = 58/186 (31%), Positives = 75/186 (40%), Gaps = 21/186 (11%)
Query: 867 QCPCKLGVTGLRCNQCEPHRYNLTID--------NFQHCQMCECDSLGTLPGTICDPISG 918
+C C LG +GL C C P Y L C C+C+ +L CDP +
Sbjct: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL----CDPETS 1434
Query: 919 QCL-CVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAVNHICNSLTGQ------C 970
C C + G C +C G+Y I G C C+C + N+ S + C
Sbjct: 1435 ICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC 1494
Query: 971 VCQDASIAGQRCDQCKDHYFGFDPQTG-RCQPCNCHLSGALNETCHLVTGQCFCKQFVTG 1029
GQ C++C Y G G CQ C C G+L C VTG C C+ TG
Sbjct: 1495 TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATG 1554
Query: 1030 SKCDAC 1035
KCD C
Sbjct: 1555 RKCDGC 1560
Score = 91.7 bits (226), Expect = 2e-17
Identities = 60/219 (27%), Positives = 90/219 (41%), Gaps = 31/219 (14%)
Query: 661 QCNCKRHVSGRQCNQCQNGFYNLQELDPDG---------CSPCNCNTSGTVDGDITCHQN 711
+C+C SG C C GFY L+ P G C PC CN ++ C
Sbjct: 1379 KCDCPLGYSGLSCEACLPGFYRLRS-QPGGRTPGPTLGTCVPCQCNGHSSL-----CDPE 1432
Query: 712 SGQCK-CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQ----- 765
+ C+ C+ + G C+ C G+ + C+ C C L S N F +
Sbjct: 1433 TSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDY 1492
Query: 766 --CECKKEAKGLQCDTCRENFYGLDVT---NCKACDCDTAGSLPGTVCNAKTGQCICKPN 820
C + +G C+ C + G +C+ C+CD GSLP C+ TG C C+P
Sbjct: 1493 RCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLP-VPCDPVTGFCTCRPG 1551
Query: 821 VEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSL 859
GR+C+ C + + C+ C + TG + G L
Sbjct: 1552 ATGRKCDGCK----HWHAREGWECVFCGDECTGLLLGDL 1586
Score = 91.3 bits (225), Expect = 2e-17
Identities = 64/234 (27%), Positives = 99/234 (42%), Gaps = 31/234 (13%)
Query: 607 DCEHNTTGRNCELCKDYFFR----QVGADPS-AIDVCKPCDCDTVGTRNGSILCDQIGGQ 661
DC +G +CE C F+R G P + C PC C+ S LCD
Sbjct: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN-----GHSSLCDPETSI 1435
Query: 662 C-NCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNC---------NTSGTVDG--DITCH 709
C NC+ H +G C +C G+Y + + P+ C C C + S +G D C
Sbjct: 1436 CQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC- 1494
Query: 710 QNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECK 769
C G C+ C G+ C+ C+C+ +GS+ C+P +G C C+
Sbjct: 1495 -----TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCR 1549
Query: 770 KEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEG 823
A G +CD C+ +++ + C C + G L G + A+ Q + N+ G
Sbjct: 1550 PGATGRKCDGCK-HWHAREGWECVFCGDECTGLLLGDL--ARLEQMVMSINLTG 1600
Score = 85.1 bits (209), Expect = 2e-15
Identities = 64/231 (27%), Positives = 91/231 (39%), Gaps = 46/231 (19%)
Query: 711 NSGQCKCKANVIGLRCDHCNFGF--KFLRSFNDVGCEPCQ-CNLHGSVNKFCNPHS---- 763
N +C+C+ N G CD C GF K R+ + C+ CN HG + +
Sbjct: 303 NKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARR 362
Query: 764 -------------GQC-ECKKEAKGLQCDTCRENFYGLDVTN------CKACDCDTAGSL 803
G C C + G+ C+TC + F+ + C+ C CD GSL
Sbjct: 363 NLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSL 422
Query: 804 PGTVC---------NAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGT 854
VC G C CK G C++C G Y + C CNC G+
Sbjct: 423 -NEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARG--YTGYPD---CKACNCSGLGS 476
Query: 855 INGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSL 905
N + G C CK V G C++C+ +NL DN++ C C C +
Sbjct: 477 KNE----DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGV 523
Score = 84.3 bits (207), Expect = 3e-15
Identities = 54/188 (28%), Positives = 78/188 (41%), Gaps = 22/188 (11%)
Query: 765 QCECKKEAKGLQCDTCRENFY-----------GLDVTNCKACDCDTAGSLPGTVCNAKTG 813
+C+C GL C+ C FY G + C C C+ SL C+ +T
Sbjct: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL----CDPETS 1434
Query: 814 QCI-CKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTG----QC 868
C C+ + G C +C G + + + C C C + N + G +C
Sbjct: 1435 ICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC 1494
Query: 869 P-CKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQ 927
C G G C +C P + CQ CECD G+LP CDP++G C C P
Sbjct: 1495 TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLP-VPCDPVTGFCTCRPGAT 1553
Query: 928 GRRCNQCQ 935
GR+C+ C+
Sbjct: 1554 GRKCDGCK 1561
Score = 82.4 bits (202), Expect = 1e-14
Identities = 53/192 (27%), Positives = 78/192 (40%), Gaps = 27/192 (14%)
Query: 546 GLHCDRCLPLY---NDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGG 602
GL C+ CLP + +P + C PCQCN HS C S
Sbjct: 1388 GLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETS------------- 1434
Query: 603 GVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNG-SILCDQIG-- 659
+C +C+H+T G CE C ++ V P+ C+ C C + + N S C G
Sbjct: 1435 -ICQNCQHHTAGDFCERCALGYYGIVKGLPND---CQQCACPLISSSNNFSPSCVAEGLD 1490
Query: 660 -GQCN-CKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKC 717
+C C R G+ C +C G+ C C C+ G++ + C +G C C
Sbjct: 1491 DYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSL--PVPCDPVTGFCTC 1548
Query: 718 KANVIGLRCDHC 729
+ G +CD C
Sbjct: 1549 RPGATGRKCDGC 1560
Score = 82.0 bits (201), Expect = 1e-14
Identities = 63/227 (27%), Positives = 84/227 (37%), Gaps = 48/227 (21%)
Query: 862 NKSTGQCPCKLGVTGLRCNQCEP--HRYNLTIDNF---QHCQMCECDSLG---------- 906
NKS +C C+ G C+QC P H+ F C+ C C
Sbjct: 303 NKS--RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA 360
Query: 907 ------TLPGTICDPISGQCL-CVPNRQGRRCNQCQPGFY----ISPGNATGCLPCSCHT 955
+ G G C+ C N G C C GF+ +SP C PC C
Sbjct: 361 RRNLSLNIRGKYIG--GGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDP 418
Query: 956 TGAVNHIC---------NSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHL 1006
G++N +C G C C+ G CD+C Y G+ C+ CNC
Sbjct: 419 IGSLNEVCVKDEKHARRGLAPGSCHCK-TGFGGVSCDRCARGYTGYPD----CKACNCSG 473
Query: 1007 SGALNET-CHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK 1052
G+ NE C G C CK+ V G C C +L +N GC +
Sbjct: 474 LGSKNEDPCF---GPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDE 517
Score = 73.9 bits (180), Expect = 4e-12
Identities = 81/351 (23%), Positives = 161/351 (45%), Gaps = 39/351 (11%)
Query: 1541 FTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGK 1600
+ I + +T V + L+ + S ++ A++++KG++ FL+D GS V D
Sbjct: 2167 YNNIVVNVKTAVADNLLFYLGS-AKFIDFLAIEMRKGKVSFLWDV-GSGVGRVEYPD--L 2222
Query: 1601 QYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILN---------GSTV--IGDNTGVFLG 1649
D W+ I+A R G I++ + ++I+ G T+ + N +F+G
Sbjct: 2223 TIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVG 2282
Query: 1650 GLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNSWEGC 1709
GL L+K + F GC+ + +F + P +W + + + V E
Sbjct: 2283 GLTGK---LKKADAVRVITFTGCMGETYF--DNKPIGLWNFREKEGDCKGCTVSPQVEDS 2337
Query: 1710 PASLNEGAQFLGAGF-LELHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAME 1768
++ QF G G+ L P ++ ++ + FKFRT + LL+++ +D DF+++E
Sbjct: 2338 EGTI----QFDGEGYALVSRPIRWYPNIS-TVMFKFRTFSSSALLMYLATRDLRDFMSVE 2392
Query: 1769 LKSGILTFRLNTSLAFTQVDLLLGLSYCNGKWNKVI---IKKEGSFISASVNGLMKH--- 1822
L G + +++ L ++ ++ +GKW I+K+ + ++ +
Sbjct: 2393 LTDGHI--KVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIA 2450
Query: 1823 ASESGDQ---PLVVNSPVYVGGIPQELLNSYQHLCLEQGFGGCMKDVKFTR 1870
S SG+ L + +Y GG+P L N + L++ + GC+KD++ +R
Sbjct: 2451 TSSSGNNFGLDLKADDKIYFGGLP-TLRNLRPEVNLKK-YSGCLKDIEISR 2499
Score = 67.0 bits (162), Expect = 5e-10
Identities = 45/163 (27%), Positives = 71/163 (43%), Gaps = 22/163 (13%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQ-ESFTEGLHCDRC-LPLYNDKPFRQGDQVYAFNCKPC 575
CQC+GH+ CD P +C + T G C+RC L Y D C+ C
Sbjct: 1420 CQCNGHSSLCD----PETSICQNCQHHTAGDFCERCALGYYGIVKGLPND------CQQC 1469
Query: 576 QCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAI 635
C S S +++ S + +R C C G+ CE C + G+ +
Sbjct: 1470 ACPLISSSNNFSPSCVAEGLDDYR-----CTACPRGYEGQYCERCAPGY---TGSPGNPG 1521
Query: 636 DVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQN 678
C+ C+CD G+ + CD + G C C+ +GR+C+ C++
Sbjct: 1522 GSCQECECDPYGSL--PVPCDPVTGFCTCRPGATGRKCDGCKH 1562
Score = 63.2 bits (152), Expect = 7e-09
Identities = 81/351 (23%), Positives = 145/351 (41%), Gaps = 52/351 (14%)
Query: 1520 IRFIGNGYCKF--PSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKG 1577
I+F G GY P +P + + + FRT L+++ A+ + ++ +++L G
Sbjct: 2341 IQFDGEGYALVSRPIRWYP---NISTVMFKFRTFSSSALLMYLATR-DLRDFMSVELTDG 2396
Query: 1578 RLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGS 1637
+ +D V + +H +DGKW R Q I++ I T + S
Sbjct: 2397 HIKVSYDLGSGMASVVSNQNH----NDGKWKSFTLSRIQKQANISIVDIDTNQEENIATS 2452
Query: 1638 TVIGDNTG--------VFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWE 1689
+ G+N G ++ GGLP T+ PE+ K + GCLKD+ +
Sbjct: 2453 SS-GNNFGLDLKADDKIYFGGLP---TLRNLRPEVNLKKYSGCLKDIEISRT-------- 2500
Query: 1690 PLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEISFKFRTDQL 1749
P + SS + + V +GC F GF+EL P G EI+ F T
Sbjct: 2501 PYNILSSPDYVGVT---KGCSLENVYTVSFPKPGFVELSPVPIDVGT--EINLSFSTKNE 2555
Query: 1750 NGLLLF-----------VYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLS---Y 1795
+G++L + G + + L G L L+T A T +++ +
Sbjct: 2556 SGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTG-ARTMRKIVIRPEPNLF 2614
Query: 1796 CNGKWNKVIIKKEGSFISASVNGLMKHASE-SGDQPLVVNSPVYVGGIPQE 1845
+G+ + V +++ + V+ ++ + +QP+ V ++VGG P E
Sbjct: 2615 HDGREHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVKK-LFVGGAPPE 2664
Score = 44.3 bits (103), Expect = 0.003
Identities = 27/94 (28%), Positives = 39/94 (41%), Gaps = 18/94 (19%)
Query: 534 YRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPF 593
YRC + EG +C+RC P Y P G +C+ C+C+ + + DP
Sbjct: 1492 YRCTACPRGY-EGQYCERCAPGYTGSPGNPGG-----SCQECECDPYGS---LPVPCDPV 1542
Query: 594 PFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQ 627
G C C TGR C+ CK + R+
Sbjct: 1543 T--------GFC-TCRPGATGRKCDGCKHWHARE 1567
Score = 37.0 bits (84), Expect = 0.51
Identities = 39/165 (23%), Positives = 69/165 (41%), Gaps = 11/165 (6%)
Query: 1518 KGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKG 1577
+G F G G+ K V D ++ FRT G+++ +S + + +++
Sbjct: 2936 RGTYFDGTGFAKAVGG-FKVGLDLL-VEFEFRTTTTTGVLLGISS--QKMDGMGIEMIDE 2991
Query: 1578 RLYFLFDPQGSPVEVTTTNDHGK--QYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILN 1635
+L F D T D G DG+WH++ A + + ++T+DG + +
Sbjct: 2992 KLMFHVDNGAG--RFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNP 3049
Query: 1636 GSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMK 1680
ST N VF+GG P L++ F GC++ + K
Sbjct: 3050 ASTSADTNDPVFVGGFPDD---LKQFGLTTSIPFRGCIRSLKLTK 3091
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 275 bits (704), Expect = 7e-73
Identities = 171/471 (36%), Positives = 229/471 (48%), Gaps = 52/471 (11%)
Query: 604 VCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC- 662
VC C TG +CE C R G I C+PC C + CD + G+C
Sbjct: 723 VCQ-CPPGYTGSSCESCWPRHRRVNGTIFGGI--CEPCQCF-----GHAESCDDVTGECL 774
Query: 663 NCKRHVSGRQCNQCQNGFYNLQELDP-DGCSPCNCNTSGTVDG-DITCHQNSGQ---CK- 716
NCK H G C++C GFY + C PC C + + TCH + C
Sbjct: 775 NCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDG 834
Query: 717 CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCN--LHGSVNKFCNPHSGQCE-CKKEAK 773
C G RC+ C G+ S C+PCQCN L S+ C+ SG C CK
Sbjct: 835 CPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTT 894
Query: 774 GLQCDTCRENFYG--LDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLE 831
G C+ C + ++G +D NC+ C C+ GS VC+++TGQC C+ NV+G++C+KC
Sbjct: 895 GRYCELCADGYFGDAVDAKNCQPCRCNAGGSF-SEVCHSQTGQCECRANVQGQRCDKCKA 953
Query: 832 GNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTI 891
G F L+ C+PCNC+ G+ S C +S GQC C+ GVTG +C++C H Y
Sbjct: 954 GTFGLQSARG--CVPCNCNSFGS--KSFDCEES-GQCWCQPGVTGKKCDRCA-HGYF--- 1004
Query: 892 DNFQH--CQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCL 949
NFQ C CEC LG CDP +G+C+C PN G +C++C P + TGC
Sbjct: 1005 -NFQEGGCTACECSHLGNN----CDPKTGRCICPPNTIGEKCSKCAPNTW-GHSITTGCK 1058
Query: 950 PCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGA 1009
C+C T G+++ CN TGQC C +G +C +C ++ + RC C+C L G
Sbjct: 1059 ACNCSTVGSLDFQCNVNTGQCNCHP-KFSGAKCTECSRGHWNYP----RCNLCDCFLPGT 1113
Query: 1010 LNETCHLVT---------GQCFCKQFVTGSKCDACVPSASHLDVNNLLGCS 1051
TC T GQC CK V G CD C P LD N LGCS
Sbjct: 1114 DATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCS 1164
Score = 273 bits (699), Expect = 2e-72
Identities = 154/456 (33%), Positives = 218/456 (47%), Gaps = 58/456 (12%)
Query: 518 CQCHGHADNC-DTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQ 576
CQC GHA++C D T + C + T G +CD+CLP + +P + + +C+PC
Sbjct: 757 CQCFGHAESCDDVTGECLNC----KDHTGGPYCDKCLPGFYGEPTKGTSE----DCQPCA 808
Query: 577 C------NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGA 630
C N+ S +CH + S+ G +CD C TG CE C + +F Q
Sbjct: 809 CPLNIPSNNFSPTCHLDRSL-----------GLICDGCPVGYTGPRCERCAEGYFGQPSV 857
Query: 631 DPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC-NCKRHVSGRQCNQCQNGFYNLQELDPD 689
+ C+PC C+ + CD + G C CK +GR C C +G++ +D
Sbjct: 858 PGGS---CQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFG-DAVDAK 913
Query: 690 GCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQC 749
C PC CN G+ CH +GQC+C+ANV G RCD C G L+S GC PC C
Sbjct: 914 NCQPCRCNAGGSFSE--VCHSQTGQCECRANVQGQRCDKCKAGTFGLQSAR--GCVPCNC 969
Query: 750 NLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCN 809
N GS + C SGQC C+ G +CD C ++ C AC+C S G C+
Sbjct: 970 NSFGSKSFDCE-ESGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTACEC----SHLGNNCD 1024
Query: 810 AKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCP 869
KTG+CIC PN G +C+KC + + + C CNC G+++ CN +TGQC
Sbjct: 1025 PKTGRCICPPNTIGEKCSKCAPNTW--GHSITTGCKACNCSTVGSLD--FQCNVNTGQCN 1080
Query: 870 CKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI--------CDPISGQCL 921
C +G +C +C + N+ C +C+C GT T C +GQC
Sbjct: 1081 CHPKFSGAKCTECSRGHW-----NYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQCT 1135
Query: 922 CVPNRQGRRCNQCQPG-FYISPGNATGCLPCSCHTT 956
C N +G C++C+PG F + N GC C C T
Sbjct: 1136 CKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGT 1171
Score = 235 bits (600), Expect = 8e-61
Identities = 138/475 (29%), Positives = 216/475 (45%), Gaps = 54/475 (11%)
Query: 546 GLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVC 605
G C+ C P + R ++ C+PCQC H++SC G C
Sbjct: 732 GSSCESCWPRHR----RVNGTIFGGICEPCQCFGHAESCD--------------DVTGEC 773
Query: 606 DDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCD-TVGTRNGSILCD---QIGGQ 661
+C+ +T G C+ C F+ + S + C+PC C + + N S C +G
Sbjct: 774 LNCKDHTGGPYCDKCLPGFYGEPTKGTS--EDCQPCACPLNIPSNNFSPTCHLDRSLGLI 831
Query: 662 CN-CKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCK-CKA 719
C+ C +G +C +C G++ + C PC CN + +C SG C CK
Sbjct: 832 CDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKP 891
Query: 720 NVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDT 779
G C+ C G+ F + + C+PC+CN GS ++ C+ +GQCEC+ +G +CD
Sbjct: 892 GTTGRYCELCADGY-FGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDK 950
Query: 780 CRENFYGL-DVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQ 838
C+ +GL C C+C++ GS C ++GQC C+P V G++C++C G F ++
Sbjct: 951 CKAGTFGLQSARGCVPCNCNSFGS-KSFDCE-ESGQCWCQPGVTGKKCDRCAHGYFNFQE 1008
Query: 839 NNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQ 898
C C C G C+ TG+C C G +C++C P+ + +I C+
Sbjct: 1009 GG---CTACECSHLGN-----NCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITT--GCK 1058
Query: 899 MCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGA 958
C C ++G+L C+ +GQC C P G +C +C G + N C C C G
Sbjct: 1059 ACNCSTVGSLDFQ-CNVNTGQCNCHPKFSGAKCTECSRGHW----NYPRCNLCDCFLPGT 1113
Query: 959 VNHICNSLTGQCVCQD--------ASIAGQRCDQCKDHYFGFDPQTG-RCQPCNC 1004
C+S T +C C D ++ G CD+C+ FG D + C C C
Sbjct: 1114 DATTCDSETKKCSCSDQTGQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYC 1168
Score = 194 bits (492), Expect = 3e-48
Identities = 138/449 (30%), Positives = 205/449 (45%), Gaps = 53/449 (11%)
Query: 336 NP-EAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTISVDLENGQYQVFYIIIQFF-SPQ 393
NP + HP++ D T W S N + + VTI++DL+ +Q+ Y+I++ SP+
Sbjct: 92 NPNQRHPITNAIDGK-NTWWQSPSIKNGIEYHY-VTITLDLQQ-VFQIAYVIVKAANSPR 148
Query: 394 PTEIRIQRKKENSLDWEDWQYFA---RNC----GAFGMKNNGDLEKPDSVNCLQL-SNFT 445
P ++R ++ ++++ WQY A C + K D V C S
Sbjct: 149 PGNWILERSLDD-VEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIH 207
Query: 446 PYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVNLRHR 505
P G + S++ N RP ++ +P L EF A IR F + H+
Sbjct: 208 PLENGEIHISLI----NGRPSADD--PSPELLEFTSARYIRLRFQRIRTLNADLMMFAHK 261
Query: 506 -------------YYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRC 552
YY+V +I++ G C C+GHA C + C E T G CD+C
Sbjct: 262 DPREIDPIVTRRYYYSVKDISVGGMCICYGHARACPLDPATNKSRCECEHNTCGDSCDQC 321
Query: 553 LPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFE-HFRG---GGGVCDDC 608
P ++ KP+R G + C+ C C+ ++ C+Y+ +V + RG GGGVC +C
Sbjct: 322 CPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINC 381
Query: 609 EHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQ-------IGGQ 661
NT G NCE C D FFR G P+ C+PC CD +G+ N + D+ G
Sbjct: 382 TQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSLNEVCVKDEKHARRGLAPGS 441
Query: 662 CNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANV 721
C+CK G C++C G+ PD C CNC+ G+ + D C G C CK NV
Sbjct: 442 CHCKTGFGGVSCDRCARGYTGY----PD-CKACNCSGLGSKNED-PCF---GPCICKENV 492
Query: 722 IGLRCDHCNFGFKFLRSFNDVGCEPCQCN 750
G C C GF L+ N GC+ C C+
Sbjct: 493 EGGDCSRCKSGFFNLQEDNWKGCDECFCS 521
Score = 124 bits (312), Expect = 2e-27
Identities = 86/289 (29%), Positives = 122/289 (42%), Gaps = 39/289 (13%)
Query: 785 YGLD-VTNCKACDCDTAGSLP--GTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNS 841
+G+D + + + ++A S P G++ A C C P G C C + R N +
Sbjct: 692 FGMDAIFRLSSVNLESAVSYPTDGSIA-AAVEVCQCPPGYTGSSCESCWPR--HRRVNGT 748
Query: 842 F---LCLPCNCDKTGTINGSLLCNKSTGQC-PCKLGVTGLRCNQCEPHRYNL-TIDNFQH 896
+C PC C + C+ TG+C CK G C++C P Y T +
Sbjct: 749 IFGGICEPCQC-----FGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSED 803
Query: 897 CQMCECD------------SLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGN 944
CQ C C L G ICD C G RC +C G++ P
Sbjct: 804 CQPCACPLNIPSNNFSPTCHLDRSLGLICDG------CPVGYTGPRCERCAEGYFGQPSV 857
Query: 945 ATG-CLPCSCHTT--GAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQP 1001
G C PC C+ ++ C+SL+G C+ G+ C+ C D YFG CQP
Sbjct: 858 PGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQP 917
Query: 1002 CNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050
C C+ G+ +E CH TGQC C+ V G +CD C A + + GC
Sbjct: 918 CRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKC--KAGTFGLQSARGC 964
Score = 106 bits (264), Expect = 7e-22
Identities = 70/223 (31%), Positives = 94/223 (42%), Gaps = 42/223 (18%)
Query: 661 QCNCKRHVSGRQCNQCQNGFYNLQE-----LDPDGCSPCNC----------------NTS 699
+C C+ + G C+QC GF+ L C CNC N S
Sbjct: 306 RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARRNLS 365
Query: 700 GTVDGDITCHQNSGQC-KCKANVIGLRCDHCNFGF---KFLRSFNDVGCEPCQCNLHGSV 755
+ G + G C C N G+ C+ C GF K + C+PC C+ GS+
Sbjct: 366 LNIRGK---YIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSL 422
Query: 756 NKFC---NPHS------GQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGT 806
N+ C H+ G C CK G+ CD C + G +CKAC+C GS
Sbjct: 423 NEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYP--DCKACNCSGLGSKNED 480
Query: 807 VCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNC 849
C G CICK NVEG C++C G F L+++N C C C
Sbjct: 481 PC---FGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
Score = 94.0 bits (232), Expect = 4e-18
Identities = 70/251 (27%), Positives = 102/251 (40%), Gaps = 51/251 (20%)
Query: 749 CNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYG--------LDVTNCKACDC--- 797
C L + NK +CEC+ G CD C F+ L T C+AC+C
Sbjct: 296 CPLDPATNK------SRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGK 349
Query: 798 ------DTAGSLPGTVCNAKT-----GQCI-CKPNVEGRQCNKCLEGNFY---LRQNNSF 842
D + N + G CI C N G C C +G F + N
Sbjct: 350 AEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPR 409
Query: 843 LCLPCNCDKTGTINGSLLCNK-------STGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQ 895
C PC+CD G++N + ++ + G C CK G G+ C++C +
Sbjct: 410 PCQPCHCDPIGSLNEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARG-----YTGYP 464
Query: 896 HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCH 954
C+ C C LG+ DP G C+C N +G C++C+ GF+ + N GC C C
Sbjct: 465 DCKACNCSGLGSKNE---DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC- 520
Query: 955 TTGAVNHICNS 965
V++ C S
Sbjct: 521 --SGVSNRCQS 529
Score = 94.0 bits (232), Expect = 4e-18
Identities = 93/337 (27%), Positives = 149/337 (44%), Gaps = 38/337 (11%)
Query: 1544 IKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYS 1603
I+ RT+ GL+ + A N ++ +QL+ G YF +D + +
Sbjct: 2789 IELEVRTEAESGLLFYMARI-NHADFATVQLRNGLPYFSYDLGSGDTHTMIPT----KIN 2843
Query: 1604 DGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTG-VFLGGLPRSYTILRKDP 1662
DG+WH+I +R + G + +DG + I I D G +++GGLP +YT R P
Sbjct: 2844 DGQWHKIKIMRSKQEGILYVDG--ASNRTISPKKADILDVVGMLYVGGLPINYTTRRIGP 2901
Query: 1663 EIIQKGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGA 1722
+ GC++++H + P D + +V C A+ G F G
Sbjct: 2902 --VTYSIDGCVRNLHMAE--------APADLEQPTSSFHVGT----CFANAQRGTYFDGT 2947
Query: 1723 GFLELHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRL-NTS 1781
GF + F G++ + F+FRT G+LL + + D + +E+ L F + N +
Sbjct: 2948 GFAKA-VGGFKVGLDLLVEFEFRTTTTTGVLLGI-SSQKMDGMGIEMIDEKLMFHVDNGA 3005
Query: 1782 LAFTQV-DLLLGLSYCNGKWNKVIIKKEGSFISASVNGLM------KHASESGDQPLVVN 1834
FT V D + C+G+W+KV K I +V+G AS S D N
Sbjct: 3006 GRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSAD----TN 3061
Query: 1835 SPVYVGGIPQELLNSYQHLCLEQGFGGCMKDVKFTRG 1871
PV+VGG P +L L F GC++ +K T+G
Sbjct: 3062 DPVFVGGFPDDL--KQFGLTTSIPFRGCIRSLKLTKG 3096
Score = 92.0 bits (227), Expect = 1e-17
Identities = 58/186 (31%), Positives = 75/186 (40%), Gaps = 21/186 (11%)
Query: 867 QCPCKLGVTGLRCNQCEPHRYNLTID--------NFQHCQMCECDSLGTLPGTICDPISG 918
+C C LG +GL C C P Y L C C+C+ +L CDP +
Sbjct: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL----CDPETS 1434
Query: 919 QCL-CVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAVNHICNSLTGQ------C 970
C C + G C +C G+Y I G C C+C + N+ S + C
Sbjct: 1435 ICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC 1494
Query: 971 VCQDASIAGQRCDQCKDHYFGFDPQTG-RCQPCNCHLSGALNETCHLVTGQCFCKQFVTG 1029
GQ C++C Y G G CQ C C G+L C VTG C C+ TG
Sbjct: 1495 TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATG 1554
Query: 1030 SKCDAC 1035
KCD C
Sbjct: 1555 RKCDGC 1560
Score = 91.7 bits (226), Expect = 2e-17
Identities = 60/219 (27%), Positives = 90/219 (41%), Gaps = 31/219 (14%)
Query: 661 QCNCKRHVSGRQCNQCQNGFYNLQELDPDG---------CSPCNCNTSGTVDGDITCHQN 711
+C+C SG C C GFY L+ P G C PC CN ++ C
Sbjct: 1379 KCDCPLGYSGLSCEACLPGFYRLRS-QPGGRTPGPTLGTCVPCQCNGHSSL-----CDPE 1432
Query: 712 SGQCK-CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQ----- 765
+ C+ C+ + G C+ C G+ + C+ C C L S N F +
Sbjct: 1433 TSICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDY 1492
Query: 766 --CECKKEAKGLQCDTCRENFYGLDVT---NCKACDCDTAGSLPGTVCNAKTGQCICKPN 820
C + +G C+ C + G +C+ C+CD GSLP C+ TG C C+P
Sbjct: 1493 RCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLP-VPCDPVTGFCTCRPG 1551
Query: 821 VEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSL 859
GR+C+ C + + C+ C + TG + G L
Sbjct: 1552 ATGRKCDGCK----HWHAREGWECVFCGDECTGLLLGDL 1586
Score = 91.3 bits (225), Expect = 2e-17
Identities = 64/234 (27%), Positives = 99/234 (42%), Gaps = 31/234 (13%)
Query: 607 DCEHNTTGRNCELCKDYFFR----QVGADPS-AIDVCKPCDCDTVGTRNGSILCDQIGGQ 661
DC +G +CE C F+R G P + C PC C+ S LCD
Sbjct: 1381 DCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCN-----GHSSLCDPETSI 1435
Query: 662 C-NCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNC---------NTSGTVDG--DITCH 709
C NC+ H +G C +C G+Y + + P+ C C C + S +G D C
Sbjct: 1436 CQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC- 1494
Query: 710 QNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECK 769
C G C+ C G+ C+ C+C+ +GS+ C+P +G C C+
Sbjct: 1495 -----TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCR 1549
Query: 770 KEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEG 823
A G +CD C+ +++ + C C + G L G + A+ Q + N+ G
Sbjct: 1550 PGATGRKCDGCK-HWHAREGWECVFCGDECTGLLLGDL--ARLEQMVMSINLTG 1600
Score = 85.1 bits (209), Expect = 2e-15
Identities = 64/231 (27%), Positives = 91/231 (39%), Gaps = 46/231 (19%)
Query: 711 NSGQCKCKANVIGLRCDHCNFGF--KFLRSFNDVGCEPCQ-CNLHGSVNKFCNPHS---- 763
N +C+C+ N G CD C GF K R+ + C+ CN HG + +
Sbjct: 303 NKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVARR 362
Query: 764 -------------GQC-ECKKEAKGLQCDTCRENFYGLDVTN------CKACDCDTAGSL 803
G C C + G+ C+TC + F+ + C+ C CD GSL
Sbjct: 363 NLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDPIGSL 422
Query: 804 PGTVC---------NAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGT 854
VC G C CK G C++C G Y + C CNC G+
Sbjct: 423 -NEVCVKDEKHARRGLAPGSCHCKTGFGGVSCDRCARG--YTGYPD---CKACNCSGLGS 476
Query: 855 INGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSL 905
N + G C CK V G C++C+ +NL DN++ C C C +
Sbjct: 477 KNE----DPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGV 523
Score = 84.3 bits (207), Expect = 3e-15
Identities = 54/188 (28%), Positives = 78/188 (41%), Gaps = 22/188 (11%)
Query: 765 QCECKKEAKGLQCDTCRENFY-----------GLDVTNCKACDCDTAGSLPGTVCNAKTG 813
+C+C GL C+ C FY G + C C C+ SL C+ +T
Sbjct: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSL----CDPETS 1434
Query: 814 QCI-CKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTG----QC 868
C C+ + G C +C G + + + C C C + N + G +C
Sbjct: 1435 ICQNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRC 1494
Query: 869 P-CKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQ 927
C G G C +C P + CQ CECD G+LP CDP++G C C P
Sbjct: 1495 TACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLP-VPCDPVTGFCTCRPGAT 1553
Query: 928 GRRCNQCQ 935
GR+C+ C+
Sbjct: 1554 GRKCDGCK 1561
Score = 82.4 bits (202), Expect = 1e-14
Identities = 53/192 (27%), Positives = 78/192 (40%), Gaps = 27/192 (14%)
Query: 546 GLHCDRCLPLY---NDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGG 602
GL C+ CLP + +P + C PCQCN HS C S
Sbjct: 1388 GLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETS------------- 1434
Query: 603 GVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNG-SILCDQIG-- 659
+C +C+H+T G CE C ++ V P+ C+ C C + + N S C G
Sbjct: 1435 -ICQNCQHHTAGDFCERCALGYYGIVKGLPND---CQQCACPLISSSNNFSPSCVAEGLD 1490
Query: 660 -GQCN-CKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKC 717
+C C R G+ C +C G+ C C C+ G++ + C +G C C
Sbjct: 1491 DYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSL--PVPCDPVTGFCTC 1548
Query: 718 KANVIGLRCDHC 729
+ G +CD C
Sbjct: 1549 RPGATGRKCDGC 1560
Score = 82.0 bits (201), Expect = 1e-14
Identities = 63/227 (27%), Positives = 84/227 (37%), Gaps = 48/227 (21%)
Query: 862 NKSTGQCPCKLGVTGLRCNQCEP--HRYNLTIDNF---QHCQMCECDSLG---------- 906
NKS +C C+ G C+QC P H+ F C+ C C
Sbjct: 303 NKS--RCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDENVA 360
Query: 907 ------TLPGTICDPISGQCL-CVPNRQGRRCNQCQPGFY----ISPGNATGCLPCSCHT 955
+ G G C+ C N G C C GF+ +SP C PC C
Sbjct: 361 RRNLSLNIRGKYIG--GGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDP 418
Query: 956 TGAVNHIC---------NSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHL 1006
G++N +C G C C+ G CD+C Y G+ C+ CNC
Sbjct: 419 IGSLNEVCVKDEKHARRGLAPGSCHCK-TGFGGVSCDRCARGYTGYPD----CKACNCSG 473
Query: 1007 SGALNET-CHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK 1052
G+ NE C G C CK+ V G C C +L +N GC +
Sbjct: 474 LGSKNEDPCF---GPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDE 517
Score = 70.9 bits (172), Expect = 3e-11
Identities = 79/353 (22%), Positives = 159/353 (45%), Gaps = 39/353 (11%)
Query: 1541 FTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGK 1600
+ I + +T V + L+ + S ++ A++++KG++ FL+D GS V D
Sbjct: 2167 YNNIVVNVKTAVADNLLFYLGS-AKFIDFLAIEMRKGKVSFLWDV-GSGVGRVEYPD--L 2222
Query: 1601 QYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILN---------GSTV--IGDNTGVFLG 1649
D W+ I+A R G I++ + ++I+ G T+ + N +F+G
Sbjct: 2223 TIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVG 2282
Query: 1650 GLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNSWEGC 1709
GL L+K + F GC+ + +F + P +W + + + V E
Sbjct: 2283 GLTGK---LKKADAVRVITFTGCMGETYF--DNKPIGLWNFREKEGDCKGCTVSPQVEDS 2337
Query: 1710 PASLNEGAQFLGAGF-LELHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAME 1768
++ QF G G+ L P ++ ++ + FKFRT + LL+++ +D DF+++E
Sbjct: 2338 EGTI----QFDGEGYALVSRPIRWYPNIS-TVMFKFRTFSSSALLMYLATRDLRDFMSVE 2392
Query: 1769 LKSGILTFRLNTSLAFTQVDLLLGLSYCNGKWNKVI---IKKEGSFISASVNGLMKH--- 1822
L G + +++ L ++ ++ +GKW I+K+ + ++ +
Sbjct: 2393 LTDGHI--KVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIA 2450
Query: 1823 ASESGDQ---PLVVNSPVYVGGIP--QELLNSYQHLCLEQGFGGCMKDVKFTR 1870
S SG+ L + +Y GG+P + L + + + GC+KD++ +R
Sbjct: 2451 TSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISR 2503
Score = 67.0 bits (162), Expect = 5e-10
Identities = 45/163 (27%), Positives = 71/163 (43%), Gaps = 22/163 (13%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQ-ESFTEGLHCDRC-LPLYNDKPFRQGDQVYAFNCKPC 575
CQC+GH+ CD P +C + T G C+RC L Y D C+ C
Sbjct: 1420 CQCNGHSSLCD----PETSICQNCQHHTAGDFCERCALGYYGIVKGLPND------CQQC 1469
Query: 576 QCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAI 635
C S S +++ S + +R C C G+ CE C + G+ +
Sbjct: 1470 ACPLISSSNNFSPSCVAEGLDDYR-----CTACPRGYEGQYCERCAPGY---TGSPGNPG 1521
Query: 636 DVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQN 678
C+ C+CD G+ + CD + G C C+ +GR+C+ C++
Sbjct: 1522 GSCQECECDPYGSL--PVPCDPVTGFCTCRPGATGRKCDGCKH 1562
Score = 62.8 bits (151), Expect = 9e-09
Identities = 80/352 (22%), Positives = 146/352 (41%), Gaps = 50/352 (14%)
Query: 1520 IRFIGNGYCKF--PSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKG 1577
I+F G GY P +P + + + FRT L+++ A+ + ++ +++L G
Sbjct: 2341 IQFDGEGYALVSRPIRWYP---NISTVMFKFRTFSSSALLMYLATR-DLRDFMSVELTDG 2396
Query: 1578 RLYFLFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGS 1637
+ +D V + +H +DGKW R Q I++ I T + S
Sbjct: 2397 HIKVSYDLGSGMASVVSNQNH----NDGKWKSFTLSRIQKQANISIVDIDTNQEENIATS 2452
Query: 1638 TVIGDNTG--------VFLGGLPRSYTI-LRKDPEIIQKGFVGCLKDVHFMKNYNPSAIW 1688
+ G+N G ++ GGLP + ++ PE+ K + GCLKD+ +
Sbjct: 2453 SS-GNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRT------- 2504
Query: 1689 EPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEISFKFRTDQ 1748
P + SS + + V +GC F GF+EL P G EI+ F T
Sbjct: 2505 -PYNILSSPDYVGVT---KGCSLENVYTVSFPKPGFVELSPVPIDVGT--EINLSFSTKN 2558
Query: 1749 LNGLLLF-----------VYNKDGPDFLAMELKSGILTFRLNTSLAFTQVDLLLGLS--- 1794
+G++L + G + + L G L L+T A T +++
Sbjct: 2559 ESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTG-ARTMRKIVIRPEPNL 2617
Query: 1795 YCNGKWNKVIIKKEGSFISASVNGLMKHASE-SGDQPLVVNSPVYVGGIPQE 1845
+ +G+ + V +++ + V+ ++ + +QP+ V ++VGG P E
Sbjct: 2618 FHDGREHSVHVERTRGIFTVQVDENRRYMQNLTVEQPIEVKK-LFVGGAPPE 2668
Score = 44.3 bits (103), Expect = 0.003
Identities = 27/94 (28%), Positives = 39/94 (41%), Gaps = 18/94 (19%)
Query: 534 YRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPF 593
YRC + EG +C+RC P Y P G +C+ C+C+ + + DP
Sbjct: 1492 YRCTACPRGY-EGQYCERCAPGYTGSPGNPGG-----SCQECECDPYGS---LPVPCDPV 1542
Query: 594 PFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQ 627
G C C TGR C+ CK + R+
Sbjct: 1543 T--------GFC-TCRPGATGRKCDGCKHWHARE 1567
Score = 37.0 bits (84), Expect = 0.51
Identities = 39/165 (23%), Positives = 69/165 (41%), Gaps = 11/165 (6%)
Query: 1518 KGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKG 1577
+G F G G+ K V D ++ FRT G+++ +S + + +++
Sbjct: 2940 RGTYFDGTGFAKAVGG-FKVGLDLL-VEFEFRTTTTTGVLLGISS--QKMDGMGIEMIDE 2995
Query: 1578 RLYFLFDPQGSPVEVTTTNDHGK--QYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILN 1635
+L F D T D G DG+WH++ A + + ++T+DG + +
Sbjct: 2996 KLMFHVDNGAG--RFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNP 3053
Query: 1636 GSTVIGDNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMK 1680
ST N VF+GG P L++ F GC++ + K
Sbjct: 3054 ASTSADTNDPVFVGGFPDD---LKQFGLTTSIPFRGCIRSLKLTK 3095
>gi|119703755 laminin, beta 2 precursor [Homo sapiens]
Length = 1798
Score = 271 bits (694), Expect = 9e-72
Identities = 169/539 (31%), Positives = 260/539 (48%), Gaps = 72/539 (13%)
Query: 290 SGDLL-----RLHAQSHCRCPGSHPRVHPLAQRYCIPNDAGDT-----ADNR---VSRLN 336
+GDLL RL A S C G P YCI + D D+R +R N
Sbjct: 51 TGDLLVGRADRLTASSTCGLNGPQP--------YCIVSHLQDEKKCFLCDSRRPFSARDN 102
Query: 337 PEAHPLSFVNDNDVGTSWVSNVFTNITQLNQG---VTISVDLENGQYQVFYIIIQFFSPQ 393
P +H + +V TS+ Q G VTI +DLE ++ ++I+ F + +
Sbjct: 103 PHSHRIQ-----NVVTSFAPQRRAAWWQSENGIPAVTIQLDLE-AEFHFTHLIMTFKTFR 156
Query: 394 PTEIRIQRKKENSLDWEDWQYFARNCGAF--GMKNNGDLEKPDSVNCLQLSNFTPYSRGN 451
P + ++R + W ++YF+ +CGA G+ D V + S P + G
Sbjct: 157 PAAMLVERSADFGRTWHVYRYFSYDCGADFPGVPLAPPRHWDDVVCESRYSEIEPSTEGE 216
Query: 452 VTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVNLRHR-----Y 506
V + +L P Y++ +Q +K T +R + + + ++ R Y
Sbjct: 217 VIYRVLDPAIPIPDPYSS-----RIQNLLKITNLRVNLTRLHTLGDNLLDPRREIREKYY 271
Query: 507 YAVDEITISGRCQCHGHADNC-DTTSQPYR--------CLCSQESFTEGLHCDRCLPLYN 557
YA+ E+ + G C C+GHA C P C+C T GL+C++C Y
Sbjct: 272 YALYELVVRGNCFCYGHASECAPAPGAPAHAEGMVHGACICKHN--TRGLNCEQCQDFYR 329
Query: 558 DKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGG---GGVCDDCEHNTTG 614
D P+R + ++ C+ C+C+ H+ SCH++++V + G GGVCD C+HNT G
Sbjct: 330 DLPWRPAEDGHSHACRKCECHGHTHSCHFDMAV------YLASGNVSGGVCDGCQHNTAG 383
Query: 615 RNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQ--------IGGQCNCKR 666
R+CELC+ +F+R D VC+ CDCD +G+++G CD + GQC CK
Sbjct: 384 RHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGG-RCDSHDDPALGLVSGQCRCKE 442
Query: 667 HVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRC 726
HV G +C QC++GF+ L D GC C CN GTV G C NSG C CK V G C
Sbjct: 443 HVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPNSGSCYCKRLVTGRGC 502
Query: 727 DHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFY 785
D C G L S + +GC PC C++ G+++ C+ +GQC C++ G +C+ + ++
Sbjct: 503 DRCLPGHWGL-SHDLLGCRPCDCDVGGALDPQCDEGTGQCHCRQHMVGRRCEQVQPGYF 560
Score = 241 bits (615), Expect = 1e-62
Identities = 141/420 (33%), Positives = 188/420 (44%), Gaps = 49/420 (11%)
Query: 640 PCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTS 699
PC C+ G+ + C+ GGQC CK V GR+C+ C G+Y P GC C C+
Sbjct: 782 PCQCNPQGSLSSE--CNPHGGQCLCKPGVVGRRCDLCAPGYYGF---GPTGCQACQCSHE 836
Query: 700 GTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFC 759
G + C + SGQC C+ GLRCD C G + C PC CN H C
Sbjct: 837 GALSS--LCEKTSGQCLCRTGAFGLRCDRCQRG-----QWGFPSCRPCVCNGHADE---C 886
Query: 760 NPHSGQC-ECKKEAKGLQCDTCRENFYGLDVT----NCKACDCDTAGSLPGTVCNAKTG- 813
N H+G C C+ G C+ C F+G C+ C C PG+ + T
Sbjct: 887 NTHTGACLGCRDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEG---PGSQRHFATSC 943
Query: 814 ---------QCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKS 864
C C+ G +C C G+F C C C C+
Sbjct: 944 HQDEYSQQIVCHCRAGYTGLRCEACAPGHFGDPSRPGGRCQLCECSGNIDPMDPDACDPH 1003
Query: 865 TGQC-PCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI-------CDPI 916
TGQC C G C C+P + Q C C C+ LGT P CDP
Sbjct: 1004 TGQCLRCLHHTEGPHCAHCKPGFHGQAAR--QSCHRCTCNLLGTNPQQCPSPDQCHCDPS 1061
Query: 917 SGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDA 975
SGQC C+PN QG C++C P F+ ++ G+ GC PC+CH + A CN TGQC C+ A
Sbjct: 1062 SGQCPCLPNVQGPSCDRCAPNFWNLTSGH--GCQPCACHPSRARGPTCNEFTGQCHCR-A 1118
Query: 976 SIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDAC 1035
G+ C +C++ ++G DP +C C+C G CH TG C C+ V+G +CD C
Sbjct: 1119 GFGGRTCSECQELHWG-DPGL-QCHACDCDSRGIDTPQCHRFTGHCSCRPGVSGVRCDQC 1176
Score = 216 bits (550), Expect = 5e-55
Identities = 123/378 (32%), Positives = 178/378 (47%), Gaps = 32/378 (8%)
Query: 676 CQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKF 735
C +L L +G PC CN G++ + C+ + GQC CK V+G RCD C G+
Sbjct: 765 CAPLLISLSTLIYNGALPCQCNPQGSLSSE--CNPHGGQCLCKPGVVGRRCDLCAPGYY- 821
Query: 736 LRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKAC 795
F GC+ CQC+ G+++ C SGQC C+ A GL+CD C+ +G +C+ C
Sbjct: 822 --GFGPTGCQACQCSHEGALSSLCEKTSGQCLCRTGAFGLRCDRCQRGQWGF--PSCRPC 877
Query: 796 DCDTAGSLPGTVCNAKTGQCI-CKPNVEGRQCNKCLEG-NFYLRQNNSFLCLPCNCDK-- 851
C+ CN TG C+ C+ + G C +C+ G + R C PC C +
Sbjct: 878 VCNGHAD----ECNTHTGACLGCRDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGP 933
Query: 852 TGTINGSLLCNKSTGQ----CPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECD-SLG 906
+ + C++ C C+ G TGLRC C P + CQ+CEC ++
Sbjct: 934 GSQRHFATSCHQDEYSQQIVCHCRAGYTGLRCEACAPGHFGDPSRPGGRCQLCECSGNID 993
Query: 907 TLPGTICDPISGQCL-CVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNS 965
+ CDP +GQCL C+ + +G C C+PGF+ C C+C+ G C S
Sbjct: 994 PMDPDACDPHTGQCLRCLHHTEGPHCAHCKPGFH-GQAARQSCHRCTCNLLGTNPQQCPS 1052
Query: 966 --------LTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLV 1017
+GQC C ++ G CD+C +++ G CQPC CH S A TC+
Sbjct: 1053 PDQCHCDPSSGQCPCL-PNVQGPSCDRCAPNFWNLTSGHG-CQPCACHPSRARGPTCNEF 1110
Query: 1018 TGQCFCKQFVTGSKCDAC 1035
TGQC C+ G C C
Sbjct: 1111 TGQCHCRAGFGGRTCSEC 1128
Score = 176 bits (445), Expect = 7e-43
Identities = 141/495 (28%), Positives = 194/495 (39%), Gaps = 92/495 (18%)
Query: 518 CQCHGHAD-NCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFN---CK 573
CQC+ + + +CLC G CD C P Y Y F C+
Sbjct: 783 CQCNPQGSLSSECNPHGGQCLCKPG--VVGRRCDLCAPGY-----------YGFGPTGCQ 829
Query: 574 PCQCNSH---SKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGA 630
CQC+ S C G C C G C+ C+ R
Sbjct: 830 ACQCSHEGALSSLCEKT--------------SGQCL-CRTGAFGLRCDRCQ----RGQWG 870
Query: 631 DPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC-NCKRHVSGRQCNQCQNGFYNLQELDPD 689
PS C+PC C+ C+ G C C+ H G C +C GF+ L
Sbjct: 871 FPS----CRPCVCNGHADE-----CNTHTGACLGCRDHTGGEHCERCIAGFHGDPRLPYG 921
Query: 690 G-CSPCNCNTSGTVDGDI--TCHQNSGQ----CKCKANVIGLRCDHCNFGFKFLRSFNDV 742
G C PC C +CHQ+ C C+A GLRC+ C G S
Sbjct: 922 GQCRPCPCPEGPGSQRHFATSCHQDEYSQQIVCHCRAGYTGLRCEACAPGHFGDPSRPGG 981
Query: 743 GCEPCQCNLHGSVNKF----CNPHSGQC-ECKKEAKGLQCDTCRENFYGLDVT-NCKACD 796
C+ C+C+ G+++ C+PH+GQC C +G C C+ F+G +C C
Sbjct: 982 RCQLCECS--GNIDPMDPDACDPHTGQCLRCLHHTEGPHCAHCKPGFHGQAARQSCHRCT 1039
Query: 797 CDTAGSLPGTV-------CNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNC 849
C+ G+ P C+ +GQC C PNV+G C++C + L + C PC C
Sbjct: 1040 CNLLGTNPQQCPSPDQCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHG--CQPCAC 1097
Query: 850 DKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLP 909
+ + CN+ TGQC C+ G G C++C+ + D C C+CDS G +
Sbjct: 1098 HPSRARGPT--CNEFTGQCHCRAGFGGRTCSECQELHWG---DPGLQCHACDCDSRG-ID 1151
Query: 910 GTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQ 969
C +G C C P G RC+QC GF G C PC H C
Sbjct: 1152 TPQCHRFTGHCSCRPGVSGVRCDQCARGF---SGIFPACHPC---------HACFG-DWD 1198
Query: 970 CVCQDASIAGQRCDQ 984
V QD + QR +Q
Sbjct: 1199 RVVQDLAARTQRLEQ 1213
Score = 150 bits (379), Expect = 3e-35
Identities = 87/255 (34%), Positives = 122/255 (47%), Gaps = 30/255 (11%)
Query: 713 GQCKCKANVIGLRCDHCNFGFKFL-----RSFNDVGCEPCQCNLHGSVNKFC-------- 759
G C CK N GL C+ C ++ L + C C+C+ H F
Sbjct: 308 GACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLASG 367
Query: 760 NPHSGQCE-CKKEAKGLQCDTCRENFYG------LDVTNCKACDCDTAGSLPGTVCNAK- 811
N G C+ C+ G C+ CR FY D C++CDCD GS G C++
Sbjct: 368 NVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPMGSQDGGRCDSHD 427
Query: 812 -------TGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKS 864
+GQC CK +V G +C +C +G F L ++ C C C+ GT+ GS C+ +
Sbjct: 428 DPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTVPGSTPCDPN 487
Query: 865 TGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVP 924
+G C CK VTG C++C P + L+ D C+ C+CD G L CD +GQC C
Sbjct: 488 SGSCYCKRLVTGRGCDRCLPGHWGLSHD-LLGCRPCDCDVGGALDPQ-CDEGTGQCHCRQ 545
Query: 925 NRQGRRCNQCQPGFY 939
+ GRRC Q QPG++
Sbjct: 546 HMVGRRCEQVQPGYF 560
Score = 144 bits (363), Expect = 2e-33
Identities = 84/262 (32%), Positives = 122/262 (46%), Gaps = 44/262 (16%)
Query: 764 GQCECKKEAKGLQCDTCRENFYGLDVTN--------CKACDCD--------------TAG 801
G C CK +GL C+ C++ + L C+ C+C +G
Sbjct: 308 GACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHTHSCHFDMAVYLASG 367
Query: 802 SLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFL-----CLPCNCDKTGTIN 856
++ G VC+ C+ N GR C C F+ R L C C+CD G+ +
Sbjct: 368 NVSGGVCDG------CQHNTAGRHCELCRP--FFYRDPTKDLRDPAVCRSCDCDPMGSQD 419
Query: 857 GSLLCNKS-------TGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLP 909
G + +GQC CK V G RC QC + L+I + C+ C+C++ GT+P
Sbjct: 420 GGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNARGTVP 479
Query: 910 G-TICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTG 968
G T CDP SG C C GR C++C PG + + GC PC C GA++ C+ TG
Sbjct: 480 GSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCDEGTG 539
Query: 969 QCVCQDASIAGQRCDQCKDHYF 990
QC C+ + G+RC+Q + YF
Sbjct: 540 QCHCRQ-HMVGRRCEQVQPGYF 560
Score = 140 bits (352), Expect = 4e-32
Identities = 97/352 (27%), Positives = 152/352 (43%), Gaps = 39/352 (11%)
Query: 794 ACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFY-------LRQNNSFLCLP 846
A +C A P G CICK N G C +C + FY +S C
Sbjct: 289 ASECAPAPGAPAHAEGMVHGACICKHNTRGLNCEQCQD--FYRDLPWRPAEDGHSHACRK 346
Query: 847 CNCD-KTGTINGSLLC-----NKSTGQCP-CKLGVTGLRCNQCEPHRYNLTIDNFQH--- 896
C C T + + + N S G C C+ G C C P Y + +
Sbjct: 347 CECHGHTHSCHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAV 406
Query: 897 CQMCECDSLGTLPGTICDP--------ISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATG 947
C+ C+CD +G+ G CD +SGQC C + G RC QC+ GF+ +S + G
Sbjct: 407 CRSCDCDPMGSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLG 466
Query: 948 CLPCSCHTTGAV--NHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCH 1005
C C C+ G V + C+ +G C C+ + G+ CD+C ++G C+PC+C
Sbjct: 467 CRRCQCNARGTVPGSTPCDPNSGSCYCKRL-VTGRGCDRCLPGHWGLSHDLLGCRPCDCD 525
Query: 1006 LSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQ 1065
+ GAL+ C TGQC C+Q + G +C+ P +++L+ ++ RGQV
Sbjct: 526 VGGALDPQCDEGTGQCHCRQHMVGRRCEQVQPGYFRPFLDHLI------WEAEDTRGQV- 578
Query: 1066 SSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLP 1117
+ +P ++P+ + L++G + P ++ Y L L P
Sbjct: 579 -LDVVERLVTPGETPSWTGSGFVRLQEGQTLEFLVASVPKAMDYDLLLRLEP 629
Score = 39.3 bits (90), Expect = 0.10
Identities = 34/115 (29%), Positives = 45/115 (39%), Gaps = 27/115 (23%)
Query: 517 RCQCHGH-----ADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFN 571
RCQC+ + CD S C C + G CDRCLP + G
Sbjct: 469 RCQCNARGTVPGSTPCDPNSGS--CYCKR--LVTGRGCDRCLPGH------WGLSHDLLG 518
Query: 572 CKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFR 626
C+PC C+ ++DP E G G C C + GR CE + +FR
Sbjct: 519 CRPCDCDVGG-------ALDPQCDE----GTGQCH-CRQHMVGRRCEQVQPGYFR 561
>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
Length = 3075
Score = 264 bits (674), Expect = 2e-69
Identities = 161/496 (32%), Positives = 227/496 (45%), Gaps = 67/496 (13%)
Query: 492 QYYTTETAVNLRHRYYAVDEITISGRCQ---CHGHADNCDTTSQPYRCLCSQESFTEGLH 548
Q YT + + YY VD I G CQ CHGHA C+ C + T G+H
Sbjct: 713 QGYTGTSCESCLSGYYRVDGILFGGICQPCECHGHAAECNVHGVCIACAHN----TTGVH 768
Query: 549 CDRCLPLYNDKPFR--QGDQVYAFNCKPCQC------NSHSKSCHYNISVDPFPFEHFRG 600
C++CLP + +P R GD C+PC C N+ S +CH N G
Sbjct: 769 CEQCLPGFYGEPSRGTPGD------CQPCACPLTIASNNFSPTCHLN-----------DG 811
Query: 601 GGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG 660
VCD C +G CE C D ++ G + C PCDC + + CD + G
Sbjct: 812 DEVVCDWCAPGYSGAWCERCADGYY---GNPTVPGESCVPCDCSGNVDPSEAGHCDSVTG 868
Query: 661 QC-NCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKA 719
+C C + G C +C +GFY + C C C+ G+ CH +G C CK
Sbjct: 869 ECLKCLGNTDGAHCERCADGFYG-DAVTAKNCRACECHVKGS--HSAVCHLETGLCDCKP 925
Query: 720 NVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDT 779
NV G +CD C G+ L S + GC PC C++ GSV+ C GQC C G +CD
Sbjct: 926 NVTGQQCDQCLHGYYGLDSGH--GCRPCNCSVAGSVSDGCT-DEGQCHCVPGVAGKRCDR 982
Query: 780 CRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQN 839
C FY +C CDC + C+ +TG+C+C P+ +G +C +C +G++ +
Sbjct: 983 CAHGFYAYQDGSCTPCDCPHTQN----TCDPETGECVCPPHTQGVKCEECEDGHW--GYD 1036
Query: 840 NSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQM 899
C CNC G+ + C+ TG C CK G C+QC +L +F C
Sbjct: 1037 AEVGCQACNCSLVGSTHHR--CDVVTGHCQCKSKFGGRACDQC-----SLGYRDFPDCVP 1089
Query: 900 CECDSLGT------LPGTICDPI--SGQCLCVPNRQGRRCNQCQPG-FYISPGNATGCLP 950
C+CD GT L +C + +G C C N G +CN+C+ G F + N GC P
Sbjct: 1090 CDCDLRGTSGDACNLEQGLCGCVEETGACPCKENVFGPQCNECREGTFALRADNPLGCSP 1149
Query: 951 CSCHTTGAVNHICNSL 966
C C ++H+C+ L
Sbjct: 1150 CFC---SGLSHLCSEL 1162
Score = 260 bits (665), Expect = 2e-68
Identities = 156/465 (33%), Positives = 217/465 (46%), Gaps = 46/465 (9%)
Query: 607 DCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKR 666
+C TG +CE C ++R G I C+PC+C + C+ G C
Sbjct: 710 ECPQGYTGTSCESCLSGYYRVDGILFGGI--CQPCEC-----HGHAAECNVHGVCIACAH 762
Query: 667 HVSGRQCNQCQNGFYNLQELD-PDGCSPCNCN-TSGTVDGDITCHQNSGQ---CK-CKAN 720
+ +G C QC GFY P C PC C T + + TCH N G C C
Sbjct: 763 NTTGVHCEQCLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPG 822
Query: 721 VIGLRCDHCNFGFKFLRSFNDVGCEPCQC--NLHGSVNKFCNPHSGQC-ECKKEAKGLQC 777
G C+ C G+ + C PC C N+ S C+ +G+C +C G C
Sbjct: 823 YSGAWCERCADGYYGNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHC 882
Query: 778 DTCRENFYGLDVT--NCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFY 835
+ C + FYG VT NC+AC+C GS VC+ +TG C CKPNV G+QC++CL G +
Sbjct: 883 ERCADGFYGDAVTAKNCRACECHVKGS-HSAVCHLETGLCDCKPNVTGQQCDQCLHGYYG 941
Query: 836 LRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQ 895
L + C PCNC G+++ GQC C GV G RC++C H + D
Sbjct: 942 LDSGHG--CRPCNCSVAGSVSDGCT---DEGQCHCVPGVAGKRCDRCA-HGFYAYQDG-- 993
Query: 896 HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHT 955
C C+C CDP +G+C+C P+ QG +C +C+ G + GC C+C
Sbjct: 994 SCTPCDCPHTQNT----CDPETGECVCPPHTQGVKCEECEDGHWGYDAEV-GCQACNCSL 1048
Query: 956 TGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCH 1015
G+ +H C+ +TG C C+ + G+ CDQC Y F C PC+C L G + C+
Sbjct: 1049 VGSTHHRCDVVTGHCQCK-SKFGGRACDQCSLGYRDFPD----CVPCDCDLRGTSGDACN 1103
Query: 1016 LV---------TGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCS 1051
L TG C CK+ V G +C+ C L +N LGCS
Sbjct: 1104 LEQGLCGCVEETGACPCKENVFGPQCNECREGTFALRADNPLGCS 1148
Score = 257 bits (656), Expect = 2e-67
Identities = 163/503 (32%), Positives = 234/503 (46%), Gaps = 73/503 (14%)
Query: 536 CLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPF 595
C C Q +T G C+ CL Y +R ++ C+PC+C+ H+ C+ +
Sbjct: 709 CECPQ-GYT-GTSCESCLSGY----YRVDGILFGGICQPCECHGHAAECNVH-------- 754
Query: 596 EHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPS--AIDVCKPCDCD-TVGTRNGS 652
GVC C HNTTG +CE C F+ +PS C+PC C T+ + N S
Sbjct: 755 -------GVCIACAHNTTGVHCEQCLPGFY----GEPSRGTPGDCQPCACPLTIASNNFS 803
Query: 653 ILCDQIGGQ---CN-CKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITC 708
C G C+ C SG C +C +G+Y + + C PC+C SG VD
Sbjct: 804 PTCHLNDGDEVVCDWCAPGYSGAWCERCADGYYGNPTVPGESCVPCDC--SGNVDPSEAG 861
Query: 709 HQNS--GQC-KCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQ 765
H +S G+C KC N G C+ C GF + + C C+C++ GS + C+ +G
Sbjct: 862 HCDSVTGECLKCLGNTDGAHCERCADGF-YGDAVTAKNCRACECHVKGSHSAVCHLETGL 920
Query: 766 CECKKEAKGLQCDTCRENFYGLDVTN-CKACDCDTAGSLPGTVCNAKTGQCICKPNVEGR 824
C+CK G QCD C +YGLD + C+ C+C AGS+ + GQC C P V G+
Sbjct: 921 CDCKPNVTGQQCDQCLHGYYGLDSGHGCRPCNCSVAGSVSDGCTD--EGQCHCVPGVAGK 978
Query: 825 QCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEP 884
+C++C G FY Q+ S C PC+C T C+ TG+C C G++C +CE
Sbjct: 979 RCDRCAHG-FYAYQDGS--CTPCDCPHTQN-----TCDPETGECVCPPHTQGVKCEECED 1030
Query: 885 HRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGN 944
+ D CQ C C +G+ CD ++G C C GR C+QC G+ P
Sbjct: 1031 GHWG--YDAEVGCQACNCSLVGSTHHR-CDVVTGHCQCKSKFGGRACDQCSLGYRDFP-- 1085
Query: 945 ATGCLPCSCHTTGAVNHICN---------SLTGQCVCQDASIAGQRCDQCKDHYFGF--D 993
C+PC C G CN TG C C++ ++ G +C++C++ F D
Sbjct: 1086 --DCVPCDCDLRGTSGDACNLEQGLCGCVEETGACPCKE-NVFGPQCNECREGTFALRAD 1142
Query: 994 PQTGRCQPCNC----HLSGALNE 1012
G C PC C HL L +
Sbjct: 1143 NPLG-CSPCFCSGLSHLCSELED 1164
Score = 220 bits (561), Expect = 3e-56
Identities = 131/403 (32%), Positives = 195/403 (48%), Gaps = 35/403 (8%)
Query: 662 CNCKRHVSGRQCNQCQNGFYNLQELDPDG-CSPCNCNTSGTVDGDITCHQNSGQCKCKAN 720
C C + +G C C +G+Y + + G C PC C+ C+ + C N
Sbjct: 709 CECPQGYTGTSCESCLSGYYRVDGILFGGICQPCECHGHAA-----ECNVHGVCIACAHN 763
Query: 721 VIGLRCDHCNFGFKFLRSFNDVG-CEPCQCNLHGSVNKF---CNPHSGQ---CE-CKKEA 772
G+ C+ C GF S G C+PC C L + N F C+ + G C+ C
Sbjct: 764 TTGVHCEQCLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGY 823
Query: 773 KGLQCDTCRENFYGLDVTNCKAC-DCDTAGSLPGTV---CNAKTGQCI-CKPNVEGRQCN 827
G C+ C + +YG ++C CD +G++ + C++ TG+C+ C N +G C
Sbjct: 824 SGAWCERCADGYYGNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDGAHCE 883
Query: 828 KCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRY 887
+C +G FY + C C C G+ S +C+ TG C CK VTG +C+QC Y
Sbjct: 884 RCADG-FYGDAVTAKNCRACECHVKGS--HSAVCHLETGLCDCKPNVTGQQCDQCLHGYY 940
Query: 888 NLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATG 947
L D+ C+ C C G++ D GQC CVP G+RC++C GFY +
Sbjct: 941 GL--DSGHGCRPCNCSVAGSVSDGCTD--EGQCHCVPGVAGKRCDRCAHGFYAYQDGS-- 994
Query: 948 CLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLS 1007
C PC C T + C+ TG+CVC + G +C++C+D ++G+D + G CQ CNC L
Sbjct: 995 CTPCDCPHT---QNTCDPETGECVCPPHT-QGVKCEECEDGHWGYDAEVG-CQACNCSLV 1049
Query: 1008 GALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050
G+ + C +VTG C CK G CD C S + D + + C
Sbjct: 1050 GSTHHRCDVVTGHCQCKSKFGGRACDQC--SLGYRDFPDCVPC 1090
Score = 197 bits (500), Expect = 3e-49
Identities = 143/453 (31%), Positives = 206/453 (45%), Gaps = 61/453 (13%)
Query: 336 NP-EAHPLSFVNDNDVGTSWVSNVFTNITQLNQGVTISVDLENGQYQVFYIIIQFFS-PQ 393
NP E HP+S D W S N + + VTI++DL +QV Y+II+ + P+
Sbjct: 75 NPRERHPISHAIDG-TNNWWQSPSIQNGREYHW-VTITLDLRQ-VFQVAYVIIKAANAPR 131
Query: 394 PTEIRIQRKKENSLDWEDWQYFARNCGAFGMKNN-------GDLEKPDSVNCLQL-SNFT 445
P ++R + + + WQY+A + + N D V C S
Sbjct: 132 PGNWILERSLDGTT-FSPWQYYAVSDSECLSRYNITPRRGPPTYRADDEVICTSYYSRLV 190
Query: 446 PYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVNLRHR 505
P G + S++ N RP ++ +P L EF A IR + L HR
Sbjct: 191 PLEHGEIHTSLI----NGRPSADDL--SPKLLEFTSARYIRLRLQRIRTLNADLMTLSHR 244
Query: 506 -------------YYAVDEITISGRCQCHGHADNC--DTTSQPYRCLCSQESFTEGLHCD 550
YY++ +I++ G C C+GHA +C D T++ +C C E T G C+
Sbjct: 245 EPKELDPIVTRRYYYSIKDISVGGMCICYGHASSCPWDETTKKLQCQC--EHNTCGESCN 302
Query: 551 RCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFE-----HFRGGGGVC 605
RC P Y+ +P+R G C+ C C++ +K C+Y+ SV FR GGGVC
Sbjct: 303 RCCPGYHQQPWRPGTVSSGNTCEACNCHNKAKDCYYDESVAKQKKSLNTAGQFR-GGGVC 361
Query: 606 DDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQI------- 658
+C NT G NCE C D ++R P + C+PC+CD VG+ + + D +
Sbjct: 362 INCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNCDPVGSLSSVCIKDDLHSDLHNG 421
Query: 659 --GGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCK 716
GQC CK +G +C++CQ G+ D C C CN G+ D C +G C
Sbjct: 422 KQPGQCPCKEGYTGEKCDRCQLGY-----KDYPTCVSCGCNPVGSA-SDEPC---TGPCV 472
Query: 717 CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQC 749
CK NV G CD C GF L+ N GC C C
Sbjct: 473 CKENVEGKACDRCKPGFYNLKEKNPRGCSECFC 505
Score = 118 bits (296), Expect = 1e-25
Identities = 82/284 (28%), Positives = 109/284 (38%), Gaps = 45/284 (15%)
Query: 787 LDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSF---L 843
LD+ + A D A A C C G C CL G Y R + +
Sbjct: 690 LDIASSNAIDLVVA---------ADVEHCECPQGYTGTSCESCLSG--YYRVDGILFGGI 738
Query: 844 CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQ-HCQMCEC 902
C PC C + CN C TG+ C QC P Y CQ C C
Sbjct: 739 CQPCECH-----GHAAECNVHGVCIACAHNTTGVHCEQCLPGFYGEPSRGTPGDCQPCAC 793
Query: 903 D------------SLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPG-NATGCL 949
L +CD C P G C +C G+Y +P C+
Sbjct: 794 PLTIASNNFSPTCHLNDGDEVVCD------WCAPGYSGAWCERCADGYYGNPTVPGESCV 847
Query: 950 PCSCHTT---GAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHL 1006
PC C H C+S+TG+C+ + G C++C D ++G C+ C CH+
Sbjct: 848 PCDCSGNVDPSEAGH-CDSVTGECLKCLGNTDGAHCERCADGFYGDAVTAKNCRACECHV 906
Query: 1007 SGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050
G+ + CHL TG C CK VTG +CD C+ LD + GC
Sbjct: 907 KGSHSAVCHLETGLCDCKPNVTGQQCDQCLHGYYGLDSGH--GC 948
Score = 111 bits (278), Expect = 2e-23
Identities = 83/302 (27%), Positives = 132/302 (43%), Gaps = 57/302 (18%)
Query: 680 FYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSF 739
+Y+++++ G C + S + T QC+C+ N G C+ C G+
Sbjct: 258 YYSIKDISVGGMCICYGHASSCPWDETT---KKLQCQCEHNTCGESCNRCCPGYHQ---- 310
Query: 740 NDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDT 799
+P + S N C C C +AK + +Y V K +T
Sbjct: 311 -----QPWRPGTVSSGNT-CEA----CNCHNKAK--------DCYYDESVAKQKK-SLNT 351
Query: 800 AGSLPGTVCNAKTGQCI-CKPNVEGRQCNKCLEGNFYLRQNNSFL---CLPCNCDKTGTI 855
AG G G CI C N G C C++G + + + + C PCNCD G++
Sbjct: 352 AGQFRGG------GVCINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNCDPVGSL 405
Query: 856 NG---------SLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLG 906
+ L K GQCPCK G TG +C++C+ L ++ C C C+ +G
Sbjct: 406 SSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQ-----LGYKDYPTCVSCGCNPVG 460
Query: 907 TLPGTICDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAVNHICNS 965
+ +P +G C+C N +G+ C++C+PGFY + N GC C C V+ +C+S
Sbjct: 461 SASD---EPCTGPCVCKENVEGKACDRCKPGFYNLKEKNPRGCSECFCF---GVSDVCSS 514
Query: 966 LT 967
L+
Sbjct: 515 LS 516
Score = 111 bits (278), Expect = 2e-23
Identities = 71/239 (29%), Positives = 101/239 (42%), Gaps = 52/239 (21%)
Query: 661 QCNCKRHVSGRQCNQCQNGFYNLQELDP------DGCSPCNC------------------ 696
QC C+ + G CN+C G Y+ Q P + C CNC
Sbjct: 289 QCQCEHNTCGESCNRCCPG-YHQQPWRPGTVSSGNTCEACNCHNKAKDCYYDESVAKQKK 347
Query: 697 --NTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGF---KFLRSFNDVGCEPCQCNL 751
NT+G G C C N +G+ C+ C G+ + + D C PC C+
Sbjct: 348 SLNTAGQFRGGGVC------INCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNCDP 401
Query: 752 HGSVNKFC---NPHS--------GQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTA 800
GS++ C + HS GQC CK+ G +CD C+ + D C +C C+
Sbjct: 402 VGSLSSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQLGYK--DYPTCVSCGCNPV 459
Query: 801 GSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSL 859
GS C TG C+CK NVEG+ C++C G + L++ N C C C + SL
Sbjct: 460 GSASDEPC---TGPCVCKENVEGKACDRCKPGFYNLKEKNPRGCSECFCFGVSDVCSSL 515
Score = 105 bits (263), Expect = 9e-22
Identities = 63/212 (29%), Positives = 95/212 (44%), Gaps = 27/212 (12%)
Query: 715 CKCKANVIGLRCDHCNFGFKF--LRSFNDVG-------CEPCQCNLHGSVNKFCNPHSGQ 765
C C +G C C G+ L + +D G C PC CN H C+P++G+
Sbjct: 1362 CVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDT---CDPNTGK 1418
Query: 766 C-ECKKEAKGLQCDTCRENFYGL---DVTNCKACDCD---TAGSLPGTVCNAKTG-QC-I 816
C C G CD C +YG ++C C C A P V +C
Sbjct: 1419 CLNCGDNTAGDHCDVCTSGYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCDA 1478
Query: 817 CKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTG 876
C EG+ C +C + Q C C+C+ G+++G C++++GQC C+LG +G
Sbjct: 1479 CLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGD--CDRTSGQCVCRLGASG 1536
Query: 877 LRCNQCEPHRYNLTIDNFQHCQMCECDSLGTL 908
LRC++CEP + D C C+ + +G L
Sbjct: 1537 LRCDECEPRHILMETD----CVSCDDECVGVL 1564
Score = 100 bits (248), Expect = 5e-20
Identities = 64/207 (30%), Positives = 93/207 (44%), Gaps = 17/207 (8%)
Query: 608 CEHNTTGRNCELCKDYFFR---QVGADPSA---IDVCKPCDCDTVGTRNGSILCDQIGGQ 661
C T G +C+ C + R G+D + C PC C+ N S CD G+
Sbjct: 1364 CPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCN-----NHSDTCDPNTGK 1418
Query: 662 C-NCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCH-QNSGQCKCKA 719
C NC + +G C+ C +G+Y C+ C C S TC + +C A
Sbjct: 1419 CLNCGDNTAGDHCDVCTSGYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCDA 1478
Query: 720 NVIGLR---CDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQ 776
++G C+ C+ + C+ C CN HGSV+ C+ SGQC C+ A GL+
Sbjct: 1479 CLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASGLR 1538
Query: 777 CDTCRENFYGLDVTNCKACDCDTAGSL 803
CD C E + L T+C +CD + G L
Sbjct: 1539 CDEC-EPRHILMETDCVSCDDECVGVL 1564
Score = 99.0 bits (245), Expect = 1e-19
Identities = 60/202 (29%), Positives = 85/202 (42%), Gaps = 29/202 (14%)
Query: 536 CLCSQESFTEGLHCDRCLPLYNDKPFR----QGDQVYAFNCKPCQCNSHSKSCHYNISVD 591
C+C T G C C P Y+ +G + C PC CN+HS +C N
Sbjct: 1362 CVCPPG--TVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNT--- 1416
Query: 592 PFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNG 651
G C +C NT G +C++C ++ +V S C C C +
Sbjct: 1417 -----------GKCLNCGDNTAGDHCDVCTSGYYGKVTGSASD---CALCACPHSPPASF 1462
Query: 652 SILCDQIGG---QCN-CKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDIT 707
S C G +C+ C G+ C +C + +Y + C C+CN G+V GD
Sbjct: 1463 SPTCVLEGDHDFRCDACLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGD-- 1520
Query: 708 CHQNSGQCKCKANVIGLRCDHC 729
C + SGQC C+ GLRCD C
Sbjct: 1521 CDRTSGQCVCRLGASGLRCDEC 1542
Score = 99.0 bits (245), Expect = 1e-19
Identities = 95/337 (28%), Positives = 142/337 (42%), Gaps = 30/337 (8%)
Query: 1544 IKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTNDHGKQYS 1603
++ S RT GLI + A NQ +Y LQL GRL+F+FD +V+ H S
Sbjct: 2739 VELSIRTFASSGLIYYMAHQ-NQADYAVLQLHGGRLHFMFDLGKGRTKVS----HPALLS 2793
Query: 1604 DGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIGDNTGVFLGGLPRSYTILRKDPE 1663
DGKWH + + G IT+DG + ++ T++ +LGGLP Y RK
Sbjct: 2794 DGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQYQ-ARKIGN 2852
Query: 1664 IIQKGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNSWEGCPASLNEGAQFLGAG 1723
I C+ DV + + LD S V C A EG F G+G
Sbjct: 2853 ITH-SIPACIGDV--------TVNSKQLDKDSPVSAFTV----NRCYAVAQEGTYFDGSG 2899
Query: 1724 FLELHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLAMELKSGILTFRLNTSLA 1783
+ L + + I+ +FRT NG+LL + + D + +EL G + F +N
Sbjct: 2900 YAALVKEGYKVQSDVNITLEFRTSSQNGVLLGI-STAKVDAIGLELVDGKVLFHVNNGAG 2958
Query: 1784 --FTQVDLLLGLSYCNGKWNKVIIKKEGSFISASVNGLMKHASESGDQPLVV--NSPVYV 1839
+ C+GKW+ + K I+ V+G A Q V N+P+YV
Sbjct: 2959 RITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESPHTQSTSVDTNNPIYV 3018
Query: 1840 GGIPQELLNSYQHLCL--EQGFGGCMKDVKFTRGAVV 1874
GG P + CL + F GC++ + + V
Sbjct: 3019 GGYPA----GVKQKCLRSQTSFRGCLRKLALIKSPQV 3051
Score = 96.3 bits (238), Expect = 7e-19
Identities = 62/194 (31%), Positives = 91/194 (46%), Gaps = 35/194 (18%)
Query: 868 CPCKLGVTGLRCNQCEP--HRYNLTIDNFQH-------CQMCECDSLGTLPGTICDPISG 918
C C G G C C P HR L + + C C C++ CDP +G
Sbjct: 1362 CVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNN----HSDTCDPNTG 1417
Query: 919 QCL-CVPNRQGRRCNQCQPGFYIS-PGNATGCLPCSC-HTTGAVNHICNSLTGQCVCQ-- 973
+CL C N G C+ C G+Y G+A+ C C+C H+ A S + CV +
Sbjct: 1418 KCLNCGDNTAGDHCDVCTSGYYGKVTGSASDCALCACPHSPPA------SFSPTCVLEGD 1471
Query: 974 -----DASIAG---QRCDQCKDHYFGFDPQT--GRCQPCNCHLSGALNETCHLVTGQCFC 1023
DA + G + C++C Y+G +PQT G CQ C+C+ G+++ C +GQC C
Sbjct: 1472 HDFRCDACLLGYEGKHCERCSSSYYG-NPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVC 1530
Query: 1024 KQFVTGSKCDACVP 1037
+ +G +CD C P
Sbjct: 1531 RLGASGLRCDECEP 1544
Score = 92.0 bits (227), Expect = 1e-17
Identities = 63/228 (27%), Positives = 92/228 (40%), Gaps = 56/228 (24%)
Query: 867 QCPCKLGVTGLRCNQCEPHRYNL-----TIDNFQHCQMCEC------------------- 902
QC C+ G CN+C P + T+ + C+ C C
Sbjct: 289 QCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSGNTCEACNCHNKAKDCYYDESVAKQKKS 348
Query: 903 -DSLGTLPGTICDPISGQCL-CVPNRQGRRCNQCQPGFY----ISPGNATGCLPCSCHTT 956
++ G G G C+ C+ N G C C G+Y +SP C PC+C
Sbjct: 349 LNTAGQFRG------GGVCINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNCDPV 402
Query: 957 GAVNHIC-----------NSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCH 1005
G+++ +C GQC C++ G++CD+C+ Y + C C C+
Sbjct: 403 GSLSSVCIKDDLHSDLHNGKQPGQCPCKEG-YTGEKCDRCQLGYKDYPT----CVSCGCN 457
Query: 1006 LSG-ALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK 1052
G A +E C TG C CK+ V G CD C P +L N GCS+
Sbjct: 458 PVGSASDEPC---TGPCVCKENVEGKACDRCKPGFYNLKEKNPRGCSE 502
Score = 84.0 bits (206), Expect = 4e-15
Identities = 56/211 (26%), Positives = 81/211 (38%), Gaps = 25/211 (11%)
Query: 766 CECKKEAKGLQCDTCRENFY------GLD------VTNCKACDCDTAGSLPGTVCNAKTG 813
C C G C C ++ G D V C C C+ C+ TG
Sbjct: 1362 CVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSD----TCDPNTG 1417
Query: 814 QCI-CKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLC---NKSTGQCP 869
+C+ C N G C+ C G + ++ C C C + + S C +C
Sbjct: 1418 KCLNCGDNTAGDHCDVCTSGYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCD 1477
Query: 870 -CKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQG 928
C LG G C +C Y CQ C+C+ G++ G CD SGQC+C G
Sbjct: 1478 ACLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGD-CDRTSGQCVCRLGASG 1536
Query: 929 RRCNQCQPGFYISPGNATGCLPCSCHTTGAV 959
RC++C+P + T C+ C G +
Sbjct: 1537 LRCDECEPRHILM---ETDCVSCDDECVGVL 1564
Score = 76.6 bits (187), Expect = 6e-13
Identities = 78/354 (22%), Positives = 150/354 (42%), Gaps = 45/354 (12%)
Query: 1538 NTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYFLFDPQGSPVEVTTTND 1597
+T++ + + +T+ P+ L+ + S ++ A+++++GR+ FL+D + +
Sbjct: 2136 STNYNTLTLNVKTQEPDNLLFYLGS-STASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDF 2194
Query: 1598 HGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIG--------DNTGVFLG 1649
D +WH I R G +++ + + + S G ++T +F+G
Sbjct: 2195 ---PIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFVG 2251
Query: 1650 GLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPLDWQSSEEQINVYNSWEGC 1709
GL ++K P + F GCL + N +W ++ + GC
Sbjct: 2252 GLGGQ---IKKSPAVKVTHFKGCLGEAFL--NGKSIGLWNYIEREGK---------CRGC 2297
Query: 1710 -PASLNEGAQFL--GAGFLELHPYMFHGGMNFEISFKFRTDQLNGLLLFVYNKDGPDFLA 1766
+S NE F G+G+ + + +I F T NGLLL++ + DFL+
Sbjct: 2298 FGSSQNEDPSFHFDGSGYSVVEKSL--PATVTQIIMLFNTFSPNGLLLYLGSYGTKDFLS 2355
Query: 1767 MELKSGILTFRLNTSLAFTQVDLLLGLSYCNGKWNKVII---KKEGSFISASVNGLMKHA 1823
+EL G ++ T L + LL Y NG W K+ +K+G
Sbjct: 2356 IELFRG--RVKVMTDLGSGPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKE 2413
Query: 1824 SESGDQP-------LVVNSPVYVGGIPQELLNSYQHLCLEQGFGGCMKDVKFTR 1870
++ G+ P + P+YVGG+P+ + + + F GC+K+++ +R
Sbjct: 2414 TKQGETPGASSDLNRLDKDPIYVGGLPRSRV--VRRGVTTKSFVGCIKNLEISR 2465
Score = 75.1 bits (183), Expect = 2e-12
Identities = 55/189 (29%), Positives = 84/189 (44%), Gaps = 23/189 (12%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577
C C+ H+D CD + +CL ++ T G HCD C Y K A +C C C
Sbjct: 1403 CSCNNHSDTCDPNTG--KCLNCGDN-TAGDHCDVCTSGYYGKVTGS-----ASDCALCAC 1454
Query: 578 NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDV 637
HS ++ + FR CD C G++CE C ++ G +
Sbjct: 1455 -PHSPPASFSPTCVLEGDHDFR-----CDACLLGYEGKHCERCSSSYY---GNPQTPGGS 1505
Query: 638 CKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCN 697
C+ CDC+ G+ +G CD+ GQC C+ SG +C++C+ + L E D C C+
Sbjct: 1506 CQKCDCNPHGSVHGD--CDRTSGQCVCRLGASGLRCDECEPR-HILMETD---CVSCDDE 1559
Query: 698 TSGTVDGDI 706
G + D+
Sbjct: 1560 CVGVLLNDL 1568
Score = 72.8 bits (177), Expect = 8e-12
Identities = 97/430 (22%), Positives = 180/430 (41%), Gaps = 60/430 (13%)
Query: 1522 FIGNGYCKFPSSTHPVNTDFTGIKASFRTKVPEGLIVFAASPGNQEEYFALQLKKGRLYF 1581
F G+GY S + T I F T P GL+++ S G ++ + +++L +GR+
Sbjct: 2310 FDGSGYSVVEKS---LPATVTQIIMLFNTFSPNGLLLYLGSYGTKD-FLSIELFRGRVKV 2365
Query: 1582 LFDPQGSPVEVTTTNDHGKQYSDGKWHEIIAIRHQAFGQITLDGIYTGSSAILNGSTVIG 1641
+ D P+ + T ++Y++G W++I R++ G + + Y S+ G
Sbjct: 2366 MTDLGSGPITLLTD----RRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPG 2421
Query: 1642 --------DNTGVFLGGLPRSYTILRKDPEIIQKGFVGCLKDVHFMKNYNPSAIWEPLDW 1693
D +++GGLPRS + R + K FVGC+K++ ++
Sbjct: 2422 ASSDLNRLDKDPIYVGGLPRSRVVRRG---VTTKSFVGCIKNLEISRS------------ 2466
Query: 1694 QSSEEQINVYNSWEGCPASLNEGAQFLGAGFLELHPYMFHGGMNFEISFKFRTDQLNGLL 1753
+ + N Y +GC FL G++EL P + ++ F T +G++
Sbjct: 2467 -TFDLLRNSYGVRKGCLLEPIRSVSFLKGGYIELPPKSLSPESEWLVT--FATTNSSGII 2523
Query: 1754 LFVYNKD----------GPDFLAMELKSGILTFRLN----TSLAFTQVDLLLGLSYCNGK 1799
L D F ++ L G + +N T L + G + +G+
Sbjct: 2524 LAALGGDVEKRGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALLHAPTG-TCSDGQ 2582
Query: 1800 WNKVIIKKEGSFISASV---NGLMKHASESGDQPLVVNSPVYVGGIPQELLNSYQHLCLE 1856
+ + + + I+ + N + + + S +YVGGIP+ S L +
Sbjct: 2583 AHSISLVRNRRIITVQLDENNPVEMKLGTLVESRTINVSNLYVGGIPEGEGTSL--LTMR 2640
Query: 1857 QGFGGCMKDVKFTRGAVVNLASVSSGAVRVNLDGC-LSTDSAVNCRGNDSILVYQGK--- 1912
+ F GC+K++ F + ++V G +V+LD C LS + DS L+ + +
Sbjct: 2641 RSFHGCIKNLIFNLELLDFNSAV--GHEQVDLDTCWLSERPKLAPDAEDSKLLPEPRAFP 2698
Query: 1913 EQSVYEGGLQ 1922
EQ V + L+
Sbjct: 2699 EQCVVDAALE 2708
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 263 bits (673), Expect = 3e-69
Identities = 331/1300 (25%), Positives = 516/1300 (39%), Gaps = 163/1300 (12%)
Query: 3559 PFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNG 3618
PF E+ + A T+ G + + T Q VP SI + +S+ ++ L W PE NG
Sbjct: 538 PFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNG 597
Query: 3619 VIKEYQI--RQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTS---SEPFL 3673
I Y I ++ TT +TGL+ YT Y + A T G +S
Sbjct: 598 KITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIF 657
Query: 3674 GQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQ-LSRNGNLLFLGGSEEQ 3732
+T + PE I + + + L WS PEKPNG++ Y+ L +N + L++ +
Sbjct: 658 VRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTT 717
Query: 3733 NFTDKNLEPNSRYTYKLEVKT--GGGSSASDDYIVQTPMSTPEEIYPPYNITV--IGPYS 3788
+ +NL P++ Y + T G G+ S V+T + P+ P NIT I
Sbjct: 718 DIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDS--APENITYKNISSGE 775
Query: 3789 IFVAWIPPGILIPE-IPVEYNVLLNDGSVTPLAFSVGHHQSTL--------LENLTPFTQ 3839
I ++++PP P I +Y + L S G+ + T+ ++ L +TQ
Sbjct: 776 IELSFLPPS--SPNGIIQKYTIYLKR--------SNGNEERTINTTSLTQNIKVLKKYTQ 825
Query: 3840 YEIRIQACQNGSCGV-SSRMFVKTPEAAPMDLNSP----VLKALGSACIEIKWMPPEKPN 3894
Y I + A GV S+ + + T E AP +SP +K L +++ W PP +PN
Sbjct: 826 YIIEVSASTLKGEGVRSAPISILTEEDAP---DSPPQDFSVKQLSGVTVKLSWQPPLEPN 882
Query: 3895 GIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACN-------- 3946
GII+ Y +Y VW+ +L+ ++ +T + +Y V
Sbjct: 883 GIILYYTVY-------------VWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRF 929
Query: 3947 SKGSVESLWSLTQTLEAPPQDFPAPWAQAT-SAHSVLLNWTKPESPNGIISHYRVVYQER 4005
G S QT E P D P A S+ S++L WT P PNGII +Y V Y R
Sbjct: 930 GDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYY--R 987
Query: 4006 PDDPTF-NSPTVHAFT--VKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQ-- 4060
TF + T+H T + + L F+ Y + A+ G +I+
Sbjct: 988 NTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVY 1047
Query: 4061 TLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVI---------KTYNIFSDGFLEYS 4111
T + P G + + + A+ + W P + NG++ +T + Y
Sbjct: 1048 TDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTY- 1106
Query: 4112 GLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLW---TDEAPPDSQLAPTVHSVKS 4168
R F L+ +T Y L + T G + + L+ ++ P S + T ++ S
Sbjct: 1107 --ERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSS 1164
Query: 4169 TSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDT 4228
TSV LSW PV PNG II Y++ +G I +D I+ E
Sbjct: 1165 TSVLLSWDPPVKPNGAIISYDL---TLQGPNENYSFITSDNYIILEE------------- 1208
Query: 4229 GLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPV-ISYVSMNPQKLLISWIP 4287
L P+T + G SS T ++ P L+PP ++ ++ + + W P
Sbjct: 1209 -LSPFTLYSFFAAARTRKGLGPSSILFFYTDESVP--LAPPQNLTLINCTSDFVWLKWSP 1265
Query: 4288 PEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELL----PFSTYSYALQACT--SGGC 4341
GI++ Y + +E + + E L P STYS + A T G
Sbjct: 1266 SPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGN 1325
Query: 4342 STSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYD-NKESLA 4400
S TT E+ P V A S + V W PP NG IT+Y+V + N ++
Sbjct: 1326 QFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVS 1385
Query: 4401 GQGLCLLVSHLQPYSQYNFSLVACTNGG----CTASVSKSAWTMEALPENMDSPTLQVTG 4456
Q L + Y F + A T+ G T VS T+ ++P N+ +Q
Sbjct: 1386 PQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQ--- 1442
Query: 4457 SESIEITWKPPRNPNGQIRSY------------ELRRDGTIVYTGLETRYRDFTLTPGVE 4504
S S +TW P G ++Y E + + Y ++ Y V
Sbjct: 1443 STSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVY 1502
Query: 4505 -------YSYTVTASNSQG-GILSPLVKDRTSPSAPSGMEPPK---LQARGPQEILVNWD 4553
Y + V AS + G G S + +T P P G PP+ + A P I ++W
Sbjct: 1503 GLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDG--PPENVHVVATSPFSISISWS 1560
Query: 4554 PPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACT 4613
P G Y + ++ + E I I + + ++ + L+ F RY + I A T
Sbjct: 1561 EPAVITGPTC-YLIDVKSVDNDEFNISFIKSNEEN---KTIEIKDLEIFTRYSVVITAFT 1616
Query: 4614 -TLGCA-----SSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKV 4667
+ A SS + T E AP PP ++ Q P L + P QPNG +
Sbjct: 1617 GNISAAYVEGKSSAEMIVTTLESAP-KDPPNNMTFQKIPDEV-TKFQLTFLPPSQPNGNI 1674
Query: 4668 LYYE--LYRRQIATQPRKSNPVLIYNGSSTSFIDSE-LLPFTEYEYQVWAVNSAG---KA 4721
Y+ +YR T + N +I ++ E L Y V+AVNSAG K
Sbjct: 1675 QVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKV 1734
Query: 4722 PSSWTWCRTGPAPPEGLRAPTFHVISS---TQAVVNISAP 4758
P T PA P+ P + T + I P
Sbjct: 1735 PMRITMDIKAPARPKTKPTPIYDATGKLLVTSTTITIRMP 1774
Score = 255 bits (651), Expect = 9e-67
Identities = 357/1426 (25%), Positives = 554/1426 (38%), Gaps = 204/1426 (14%)
Query: 3517 IVLNWRKPIQSNGPIIYYILLRNGIERFRGTSLSFSDKE---------GIQPFQEYSYQL 3567
I+L+W P NG II YI+ + + T + + + P Y ++
Sbjct: 72 ILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKV 131
Query: 3568 KACTVAGCAT-SSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQI- 3625
A AG S + T + P ++ ++ A +A A+ L W +P + NG I ++I
Sbjct: 132 AAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKIS 191
Query: 3626 -RQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGV 3684
+ G++ D + R + +TG P N +SE FL T +P
Sbjct: 192 VKHARSGIVVKDVSIRVEDILTGKLPECN-------------ENSESFLWSTASPSPTLG 238
Query: 3685 WVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSR 3744
VTP +S++ ++Q ++S E +F +L P +
Sbjct: 239 RVTPPSRTTHSSST-------------LTQNEISSVWK-------EPISFVVTHLRPYTT 278
Query: 3745 YTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITV--IGPYSIFVAWIPPGILIPE 3802
Y +++ T D IV+TP S PE PP N I S + W PP I+ +
Sbjct: 279 YLFEVSAATTEAGYI-DSTIVRTPESVPEG--PPQNCVTGNITGKSFSILWDPPTIVTGK 335
Query: 3803 IPVEYNVL-----LNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSR 3857
+ + D S L F+ NLTPFT Y++ I A + G S
Sbjct: 336 FSYRVELYGPSGRILDNSTKDLKFA--------FTNLTPFTMYDVYIAAETSAGTGPKSN 387
Query: 3858 MFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIIINY--FIYRRPAGIEEESVL 3915
+ V TP P + L + S + I W P +PNGII Y + GI E+ L
Sbjct: 388 ISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGIILENTL 447
Query: 3916 FVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVES-LWSLTQTL--EAPPQDFPAPW 3972
G E++++ + E V + S L SL + P ++FPA
Sbjct: 448 LT---GNNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPA-- 502
Query: 3973 AQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAH--- 4029
+ R +D T SP V T A
Sbjct: 503 ------------------------------RNRAEDQT--SPVVTTRNQYITDIAAEQLS 530
Query: 4030 --LYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKE-NGRALLLQ 4086
+ L PFT + I V A GE ++T + PS ++ I+ K + ++LL
Sbjct: 531 YVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIK--IINYKNISSSSILLY 588
Query: 4087 WSEPMRTNGVIKTYNIF-----SDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCA 4141
W P NG I Y I+ ++ + + ++ FL L +T Y + + A T G +
Sbjct: 589 WDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGES 648
Query: 4142 HSAPQ----PLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEG 4197
+ + +++ P S V V + + L WS P PNG II YEV+
Sbjct: 649 SLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVL------ 702
Query: 4198 KAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGH--TCSSWNV 4255
K + T Y +T L+P T + ++ GH SS
Sbjct: 703 -----------YKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLS 751
Query: 4256 VRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYR--LQRNEMLYPFSFDP 4313
VRT + P+ +P I+Y +++ ++ +S++PP NGIIQ Y L+R+ + +
Sbjct: 752 VRTSETVPDS-APENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINT 810
Query: 4314 VTFNYTDEELLPFSTYSYALQACT-SGGCSTSKPTSITTLEAAPSEVSPPDLWAV---SA 4369
+ + L ++ Y + A T G S P SI T E AP SPP ++V S
Sbjct: 811 TSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPD--SPPQDFSVKQLSG 868
Query: 4370 TQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGL---CLLVSHLQPYSQYNFSLVACT- 4425
+ + W PP NG I Y V N+ SL + L +S L +Y+ + A T
Sbjct: 869 VTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTR 928
Query: 4426 -NGGCTASVSKSAWTMEALPENMDSPTLQVT-GSESIEITWKPPRNPNGQIRSYEL---R 4480
G T S S T E P + S SI + W PP PNG I+ Y +
Sbjct: 929 FGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRN 988
Query: 4481 RDGTIVYT-GLETRYRDF----------TLTPGVEYSYTVTASNS--QGGILSPLVKDRT 4527
GT + L DF LT Y++ +TAS S G S +++ T
Sbjct: 989 TSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYT 1048
Query: 4528 SPSAPSG-MEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTH 4586
P G + ++ I V+W PP + NG + Y I + R H+
Sbjct: 1049 DQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPR-----HVRPPL 1103
Query: 4587 NSFGMQSYIVNQLKPFHRYEIRIQACTTLGCAS--SDWTFIQTPEIAPLMQPPPHLEVQM 4644
++ Y N L+ + Y ++I T G + + +I+T E P P + +
Sbjct: 1104 VTYERSIYFDN-LEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNL 1162
Query: 4645 APGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLP 4704
+ +V L W P++PNG ++ Y+L Q N I S I EL P
Sbjct: 1163 S----STSVLLSWDPPVKPNGAIISYDL-----TLQGPNENYSFI--TSDNYIILEELSP 1211
Query: 4705 FTEYEYQVWAVNSAGKAPSSWTWCRTGP----APPEGLRAPTFHVISSTQAVVNISAPGK 4760
FT Y + A G PSS + T APP+ L T +S + S
Sbjct: 1212 FTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNL---TLINCTSDFVWLKWSPSPL 1268
Query: 4761 PNGIVSLYRLFSSSAHGAETVLSE---GMATQQTLHGLQAFTNYSIGVEACT-CFNCCSK 4816
P GIV +Y F H +T+ + G T+ L GL+ + YSI V A T N
Sbjct: 1269 PGGIVKVYS-FKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQF 1327
Query: 4817 GPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSY 4862
+ T + P + + Q + ++ +W PP NG+I Y
Sbjct: 1328 SNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQY 1373
Score = 252 bits (644), Expect = 6e-66
Identities = 371/1541 (24%), Positives = 611/1541 (39%), Gaps = 160/1541 (10%)
Query: 3460 SYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLED-TIV 3518
S+ +L+PY TY + +SA + + + RT E VP+G PP N+ +
Sbjct: 267 SFVVTHLRPYTTYLFEVSAATTEAGYIDSTI-VRTPESVPEG--PPQNCVTGNITGKSFS 323
Query: 3519 LNWRKPIQSNGPIIYYILLRNGIERFRGTS---LSFSDKEGIQPFQEYSYQLKACTVAGC 3575
+ W P G Y + L R S L F+ + PF Y + A T AG
Sbjct: 324 ILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFTN-LTPFTMYDVYIAAETSAGT 382
Query: 3576 ATSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQIRQV--GKGLI 3633
S + T VP ++ + + + + ++W P + NG+I +Y+++ + G+I
Sbjct: 383 GPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGII 442
Query: 3634 HTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIII 3693
+T +TG Y N EP +G +A + I
Sbjct: 443 LENT------LLTGNNEYINDPMAPEIVNIV-----EPMVGLYEGSAEMSSDLHSLATFI 491
Query: 3694 NSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKT 3753
++ + + + S +RN + + +E+ ++ + L P + + + T
Sbjct: 492 YNSHPDKNFPARNRAEDQTSPVVTTRNQYITDI-AAEQLSYVIRRLVPFTEHMISVSAFT 550
Query: 3754 GGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLND 3813
G V+T P I N I SI + W PP P + + +
Sbjct: 551 IMGEGPPTVLSVRTRQQVPSSI-KIINYKNISSSSILLYWDPPE--YPNGKITHYTIYAM 607
Query: 3814 GSVTPLAFSVGH-HQSTLLENLTPFTQYEIRIQACQN---GSCGVSSRMFVKT----PEA 3865
T AF + S L+ L +T+Y++R+ A + S + +FV+T PE+
Sbjct: 608 ELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPES 667
Query: 3866 APMDLNSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEF 3925
+P D+ V+ I +KW PPEKPNGIII Y + + L++ + +
Sbjct: 668 SPQDVE--VIDVTADE-IRLKWSPPEKPNGIIIAYEVL-----YKNIDTLYMKNTSTTDI 719
Query: 3926 MDEGDTLRPFTLYEYRVRACNSKGSVESLWSL--TQTLEAPPQDFPAPWA-QATSAHSVL 3982
+ LRP TLY VR+ G + SL +T E P P + S+ +
Sbjct: 720 ILR--NLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIE 777
Query: 3983 LNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIG 4042
L++ P SPNGII Y +Y +R S T+ TS ++ L+ +T Y I
Sbjct: 778 LSFLPPSSPNGIIQKY-TIYLKR-------SNGNEERTINTTSLTQNIKVLKKYTQYIIE 829
Query: 4043 VVAANHAGEIL--SPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTY 4100
V A+ GE + +P +++ ++ S ++F V+Q +G + L W P+ NG+I Y
Sbjct: 830 VSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQL-SGVTVKLSWQPPLEPNGIILYY 888
Query: 4101 NIFSDGFLEYSGLN---RQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPL---WTDEAP 4154
++ +N LD Y+ + A TR G + + + AP
Sbjct: 889 TVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAP 948
Query: 4155 PDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFT 4214
D ++ S+S+ L W+ P PNG I Y V R G N T+ V
Sbjct: 949 SDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHE----VTN 1004
Query: 4215 EYNTERNTFMYNDTGLQPWTQCEYKIYTWNSA------GHTCSSWNVVRTLQAPPEGLSP 4268
+++ M T + T Y + W +A G+ S V T Q PEG
Sbjct: 1005 DFDN-----MTVSTIIDKLTIFSYYTF-WLTASTSVGNGNKSSDIIEVYTDQDIPEGFVG 1058
Query: 4269 PVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTD----EELL 4324
++Y S++ + +SW+PP Q NG++ Y + P P Y + L
Sbjct: 1059 N-LTYESISSTAINVSWVPPAQPNGLV-FYYVSLILQQTPRHVRPPLVTYERSIYFDNLE 1116
Query: 4325 PFSTYSYALQACTSGGCSTSKPTS--ITTLEAAPSEVSP--PDLWAVSATQMNVCWSPPT 4380
++ Y + T G S + I T E P E SP +S+T + + W PP
Sbjct: 1117 KYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVP-ETSPIINTFKNLSSTSVLLSWDPPV 1175
Query: 4381 VQNGKITKY---LVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSA 4437
NG I Y L + S +++ L P++ Y+F A T G S
Sbjct: 1176 KPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFF 1235
Query: 4438 WTMEALP-ENMDSPTLQVTGSESIEITWKPPRNPNGQIRSYELR----RDGTIVY---TG 4489
+T E++P + TL S+ + + W P P G ++ Y + TI Y +G
Sbjct: 1236 YTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISG 1295
Query: 4490 LETRYRDFTLTPGVEYSYTVTASN--SQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQE 4547
+T + L P YS V+A G S +VK T S P ++ + A Q
Sbjct: 1296 FKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQS 1355
Query: 4548 ILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEI 4607
+LV WDPP + NG I Y + + N+T S Y +L Y
Sbjct: 1356 VLVKWDPPKKANGIITQYMVTVER-----------NSTKVSPQDHMYTFIKLLANTSYVF 1404
Query: 4608 RIQACTTLGCASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPT-VSLLWTGPLQPNGK 4666
+++A T+ G T ++ L + P + +A Q T +L W ++P+
Sbjct: 1405 KVRASTSAGEGDE-----STCHVSTLPETVPSVPTNIAFSDVQSTSATLTW---IRPDTI 1456
Query: 4667 VLYYELYRRQIATQPRK--------------SNPVLIYNGSSTSFIDSELLPFTEYEYQV 4712
+ Y++ Y+ I TQ R +Y T L F Y +QV
Sbjct: 1457 LGYFQNYK--ITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQV 1514
Query: 4713 WAVNSAGKA-PSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNI--SAPGKPNGIVSLYR 4769
A +AG S+W +T P PP+G HV++++ ++I S P G + Y
Sbjct: 1515 AASTNAGYGNASNWISTKTLPGPPDG-PPENVHVVATSPFSISISWSEPAVITG-PTCYL 1572
Query: 4770 LFSSSAHGAETVLSEGMATQQT----LHGLQAFTNYSIGVEACTC--------FNCCSKG 4817
+ S E +S + ++ + L+ FT YS+ + A T ++
Sbjct: 1573 IDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEM 1632
Query: 4818 PTAELRTHPA-PPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSAL 4876
L + P PP+ ++ +I ++ + PP PNG I Y+ + P +
Sbjct: 1633 IVTTLESAPKDPPNNMTFQKIPDEVTK-FQLTFLPPSQPNGNIQVYQALVYREDDPTAVQ 1691
Query: 4877 PCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGS 4917
S I+ T + A L GL+ TY + V A N G+
Sbjct: 1692 IHNLSIIQKTNTFV--IAMLEGLKGGHTYNISVYAVNSAGA 1730
Score = 252 bits (644), Expect = 6e-66
Identities = 346/1480 (23%), Positives = 572/1480 (38%), Gaps = 166/1480 (11%)
Query: 3435 TGKASIEEMCSSAEETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGLSKAVRART 3494
TGK S I S + NL P+ Y+ I+A S G G + T
Sbjct: 333 TGKFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFT 392
Query: 3495 KEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGPIIYY---ILLRNGIERFRGTSLSF 3551
DVP V ++++ + + + W+KP Q NG I Y +L+ T L+
Sbjct: 393 PPDVPGAVFDLQLAEVESTQ--VRITWKKPRQPNGIINQYRVKVLVPETGIILENTLLTG 450
Query: 3552 SDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWS 3611
++ EY A + + + +G E A H +
Sbjct: 451 NN--------EYINDPMAPEIVNIV---EPMVGLYEGSAEMSSDLHSLATFIYNSHPDKN 499
Query: 3612 VPEKSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEP 3671
P ++ + + I ++ + + L P+T + +++A T G
Sbjct: 500 FPARNRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTV 559
Query: 3672 FLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQ---YQLSRNGNLLFLGG 3728
+T Q P + + + I+S+++ LYW PE PNG ++ Y + + N F
Sbjct: 560 LSVRTRQQVPSSIKII-NYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQIT 618
Query: 3729 SEEQNFTDKNLEPNSRYTYKLEVKTGGGSSA---SDDYIVQTPMSTPEEIYPPYNITVIG 3785
+ + +F L+ ++Y ++ T G S+ +D V+T PE + +
Sbjct: 619 TIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVT 678
Query: 3786 PYSIFVAWIPP----GILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYE 3841
I + W PP GI+I Y VL ++ L +L NL P T Y
Sbjct: 679 ADEIRLKWSPPEKPNGIII-----AYEVLYK--NIDTLYMKNTSTTDIILRNLRPHTLYN 731
Query: 3842 IRIQACQNGSCG--VSSRMFVKTPEAAPMDLNSPV-LKALGSACIEIKWMPPEKPNGIII 3898
I +++ G VSS + V+T E P + K + S IE+ ++PP PNGII
Sbjct: 732 ISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQ 791
Query: 3899 NYFIY-RRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKG-----SVE 3952
Y IY +R G EE ++ L+ +T Y V A KG +
Sbjct: 792 KYTIYLKRSNGNEERTI------NTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPI 845
Query: 3953 SLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFN 4012
S+ + ++PPQDF + S +V L+W P PNGII +Y V R T N
Sbjct: 846 SILTEEDAPDSPPQDFS---VKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTIN 902
Query: 4013 SPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLI--QTLESSPSGLR 4070
T L L+ Y V A+ G+ + +I QT E +PS
Sbjct: 903 V----------TETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQTPEGAPSDPP 952
Query: 4071 NFIVEQKENGRALLLQWSEPMRTNGVIKTYNIF----SDGFL----------EYSGLNRQ 4116
+ + +++L W+ P + NG+I+ Y+++ S F+ ++ +
Sbjct: 953 KDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVS 1012
Query: 4117 FLFRRLDPFTLYTLTLEACTRAGCAHSAPQ--PLWTDEAPPDSQLAP-TVHSVKSTSVEL 4173
+ +L F+ YT L A T G + + ++TD+ P+ + T S+ ST++ +
Sbjct: 1013 TIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINV 1072
Query: 4174 SWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNT-ERNTFMYNDTGLQP 4232
SW P PNG + Y + +Q + V T ER+ + N L+
Sbjct: 1073 SWVPPAQPNGLVFYYVSL------------ILQQTPRHVRPPLVTYERSIYFDN---LEK 1117
Query: 4233 WTQCEYKIYTWNSAG--HTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQ 4290
+T KI G T ++ ++T + PE SP + ++ +++ +L+SW PP +
Sbjct: 1118 YTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE-TSPIINTFKNLSSTSVLLSWDPPVK 1176
Query: 4291 SNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTSIT 4350
NG I SY L +SF EEL PF+ YS+ A T G S
Sbjct: 1177 PNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFY 1236
Query: 4351 TLEAAPSEVSPPDLWAVSATQMNVC--WSPPTVQNGKITKYLVRYDNKE-------SLAG 4401
T E+ P P +L ++ T V WSP + G + Y + E +++G
Sbjct: 1237 TDESVPL-APPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISG 1295
Query: 4402 QGLCLLVSHLQPYSQYNFSLVACT---NGGCTASVSKSAWTMEALPENMDSPTLQVTGSE 4458
+ L+P S Y+ + A T NG ++V K T E++P+ + + T +
Sbjct: 1296 FKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFT-TQESVPDVVQNMQCMATSWQ 1354
Query: 4459 SIEITWKPPRNPNGQIRSY--ELRRDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQG 4516
S+ + W PP+ NG I Y + R+ T V + + Y L Y + V AS S G
Sbjct: 1355 SVLVKWDPPKKANGIITQYMVTVERNSTKV-SPQDHMYTFIKLLANTSYVFKVRASTSAG 1413
Query: 4517 ----GILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIR-- 4570
T PS P+ + +Q+ + W P G NY + +
Sbjct: 1414 EGDESTCHVSTLPETVPSVPTNIAFSDVQS---TSATLTWIRPDTILGYFQNYKITTQLR 1470
Query: 4571 ----ELFERE-----TKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCA-SS 4620
+ +E E KI ++ H + V LK F Y ++ A T G +S
Sbjct: 1471 AQKCKEWESEECVEYQKIQYLYEAH----LTEETVYGLKKFRWYRFQVAASTNAGYGNAS 1526
Query: 4621 DWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQ 4680
+W +T P PP ++ V +A F ++S+ W+ P G Y L +
Sbjct: 1527 NWISTKTLP-GPPDGPPENVHV-VATSPF--SISISWSEPAVITGPTCY--LIDVKSVDN 1580
Query: 4681 PRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNS-------AGKAPSSWTWCRTGPA 4733
+ + N + + +L FT Y + A GK+ + A
Sbjct: 1581 DEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESA 1640
Query: 4734 PPEGLRAPTFHVISS--TQAVVNISAPGKPNGIVSLYRLF--------SSSAHGAETVLS 4783
P + TF I T+ + P +PNG + +Y+ + H +
Sbjct: 1641 PKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQK 1700
Query: 4784 EGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAELR 4823
L GL+ Y+I V A N GP +R
Sbjct: 1701 TNTFVIAMLEGLKGGHTYNISVYA---VNSAGAGPKVPMR 1737
Score = 244 bits (624), Expect = 1e-63
Identities = 342/1481 (23%), Positives = 577/1481 (38%), Gaps = 197/1481 (13%)
Query: 3638 TDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPRHIIINSTT 3697
T Q V+ + P T Y T+++ ++ + + + V++ + S
Sbjct: 14 TSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERV--GSAG 71
Query: 3698 VELYWSLPEKPNGLVSQYQLSRNGNLLFLGG--SEEQNFTDK------NLEPNSRYTYKL 3749
+ L W+ P PNG + Y + ++ ++ ++ D NL P + Y K+
Sbjct: 72 ILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKV 131
Query: 3750 EVKTGGGSSA-SDDYIVQTPMSTPEEIYPPYNITV---------------------IGPY 3787
+ G SD ++ QT S P ++ N+TV I +
Sbjct: 132 AAENSAGIGVFSDPFLFQTAESAPGKVV---NLTVEAYNASAVKLIWYLPRQPNGKITSF 188
Query: 3788 SIFVAWIPPGILIPEIPVEYNVLLND-----------------------GSVTPLAFSVG 3824
I V GI++ ++ + +L G VTP + +
Sbjct: 189 KISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTT- 247
Query: 3825 HHQSTLLEN----------------LTPFTQYEIRIQACQNGSCGVSSRMFVKTPEAAPM 3868
H STL +N L P+T Y + A G V+TPE+ P
Sbjct: 248 HSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATT-EAGYIDSTIVRTPESVPE 306
Query: 3869 DL-NSPVLKALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMD 3927
+ V + I W PP I+ F YR +L +
Sbjct: 307 GPPQNCVTGNITGKSFSILWDPPT----IVTGKFSYRVELYGPSGRIL---DNSTKDLKF 359
Query: 3928 EGDTLRPFTLYEYRVRACNSKGS-VESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWT 3986
L PFT+Y+ + A S G+ +S S+ + P F A+ S V + W
Sbjct: 360 AFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQ-VRITWK 418
Query: 3987 KPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAA 4046
KP PNGII+ YRV P+ T+ L G + +
Sbjct: 419 KPRQPNGIINQYRVKVLV-PETGIILENTL-------------LTGNNEYINDPMAPEIV 464
Query: 4047 NHAGEILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDG 4106
N ++ + + S L FI + +E +T+ V+ T N +
Sbjct: 465 NIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPARNRAED-QTSPVVTTRNQY--- 520
Query: 4107 FLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHSV 4166
+ + ++ RRL PFT + +++ A T G + T + P S ++
Sbjct: 521 ITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNI 580
Query: 4167 KSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYN 4226
S+S+ L W P PNGKI Y + ++ D F + T N+F+
Sbjct: 581 SSSSILLYWDPPEYPNGKITHYTIY------------AMELDTNRAF-QITTIDNSFLI- 626
Query: 4227 DTGLQPWTQCEYKIYTWNSAGHTCSSWN---VVRTLQAPPEGLSPPVISYVSMNPQKLLI 4283
TGL+ +T+ + ++ G + S VRT + PE SP + + + ++ +
Sbjct: 627 -TGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPES-SPQDVEVIDVTADEIRL 684
Query: 4284 SWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCST 4343
W PPE+ NGII +Y + + + + T + L P + Y+ ++++ T G
Sbjct: 685 KWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGN 744
Query: 4344 ------SKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRY---- 4393
S TS T ++AP ++ + +S+ ++ + + PP+ NG I KY +
Sbjct: 745 QVSSLLSVRTSETVPDSAPENITYKN---ISSGEIELSFLPPSSPNGIIQKYTIYLKRSN 801
Query: 4394 -DNKESLAGQGLCLLVSHLQPYSQYNFSLVACT-NGGCTASVSKSAWTMEALPEN--MDS 4449
+ + ++ L + L+ Y+QY + A T G S S T E P++ D
Sbjct: 802 GNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDF 861
Query: 4450 PTLQVTGSESIEITWKPPRNPNGQIRSYEL---RRDGTIVYTGLETRYRDFTLTPGVEYS 4506
Q++G +++++W+PP PNG I Y + R ET L VEYS
Sbjct: 862 SVKQLSGV-TVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYS 920
Query: 4507 YTVTASN--SQGGILSPLVKDRTSPSAPSGMEPPK---LQARGPQEILVNWDPPVRTNGD 4561
VTAS G S ++ +T APS +PPK I++ W PP + NG
Sbjct: 921 AYVTASTRFGDGKTRSNIISFQTPEGAPS--DPPKDVYYANLSSSSIILFWTPPSKPNGI 978
Query: 4562 IINYTLFIRELFERETKIIHINTTHNSFGMQ--SYIVNQLKPFHRYEIRIQACTTLGCAS 4619
I Y+++ R + ++ N F S I+++L F Y + A T++G +
Sbjct: 979 IQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGN 1038
Query: 4620 SDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPT-VSLLWTGPLQPNGKVLYYELYRRQIA 4678
I E+ P + T +++ W P QPNG V YY Q
Sbjct: 1039 KSSDII---EVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQ-- 1093
Query: 4679 TQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAGKAPS--SWTWCRTGPAPPE 4736
PR P L+ S F + E +T+Y ++ G + + + + +T PE
Sbjct: 1094 QTPRHVRPPLVTYERSIYFDNLE--KYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE 1151
Query: 4737 GLRAP---TFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLH 4793
+P TF +SST +++ P KPNG + Y L + + ++ L
Sbjct: 1152 --TSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSD--NYIILE 1207
Query: 4794 GLQAFTNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASF---RWS 4850
L FT YS A T GP++ L + L+ PQ TL + T+ F +WS
Sbjct: 1208 ELSPFTLYSFFAAARTRKGL---GPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWS 1264
Query: 4851 PPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKY----TGLGQKASLGGLQPYTTYK 4906
P P G++ Y + H + +T Y +G +A L GL+P +TY
Sbjct: 1265 PSPLPGGIVKVYSFKIH------------EHETDTIYYKNISGFKTEAKLVGLEPVSTYS 1312
Query: 4907 LRVVAHNEV--GSTASEWISFTTQKELPQYRAPFS-VDSNLSVVCVNWSDTFLLNGQLKE 4963
+RV A +V G+ S + FTTQ+ +P + ++ V V W NG + +
Sbjct: 1313 IRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQ 1372
Query: 4964 YVLT--DGGRRVYSGLDTTLYIPRTADKTFFFQVICTTDEG 5002
Y++T +V +I A+ ++ F+V +T G
Sbjct: 1373 YMVTVERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAG 1413
Score = 231 bits (590), Expect = 1e-59
Identities = 282/1108 (25%), Positives = 460/1108 (41%), Gaps = 126/1108 (11%)
Query: 3449 ETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRG--LSKAVRARTKEDVPQGVSPPT 3506
+T++ + +T NL+P+ Y + ++ +G G +S + RT E VP +P
Sbjct: 707 DTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDS-APEN 765
Query: 3507 WTKIDNLEDTIVLNWRKPIQSNGPI---IYYILLRNGIER--FRGTSLSFSDKEGIQPFQ 3561
T + I L++ P NG I Y+ NG E TSL+ + K ++ +
Sbjct: 766 ITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKV-LKKYT 824
Query: 3562 EYSYQLKACTVAG-CATSSKVVAATTQGVPESILPP---SITALSAVALHLSWSVPEKSN 3617
+Y ++ A T+ G S+ + T + P+S PP S+ LS V + LSW P + N
Sbjct: 825 QYIIEVSASTLKGEGVRSAPISILTEEDAPDS--PPQDFSVKQLSGVTVKLSWQPPLEPN 882
Query: 3618 GVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACT--SAGCTSSEPFLGQ 3675
G+I Y + + + T ++ L YS +TA T G T S Q
Sbjct: 883 GIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISFQ 942
Query: 3676 TLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFT 3735
T + AP + ++S+++ L+W+ P KPNG++ Y + G+ QNFT
Sbjct: 943 TPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNT----SGTFMQNFT 998
Query: 3736 -----------------DKNLEPNSRYTYKLEVKT--GGGSSASDDYIVQTPMSTPEEIY 3776
DK L S YT+ L T G G+ +SD V T PE
Sbjct: 999 LHEVTNDFDNMTVSTIIDK-LTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFV 1057
Query: 3777 PPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTP 3836
I +I V+W+PP + +++L V + +S +NL
Sbjct: 1058 GNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTYERSIYFDNLEK 1117
Query: 3837 FTQYEIRI-QACQNG-SCGVSSRMFVKTPEAAPMDLNSPVL---KALGSACIEIKWMPPE 3891
+T Y ++I + + G S ++++++KT E P SP++ K L S + + W PP
Sbjct: 1118 YTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE--TSPIINTFKNLSSTSVLLSWDPPV 1175
Query: 3892 KPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKG-- 3949
KPNG II+Y + + E+ F+ S+ + + L PFTLY + A KG
Sbjct: 1176 KPNGAIISYDLTLQG---PNENYSFITSDNYIIL----EELSPFTLYSFFAAARTRKGLG 1228
Query: 3950 --SVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPD 4007
S+ ++ APPQ+ TS V L W+ P GI+ Y E
Sbjct: 1229 PSSILFFYTDESVPLAPPQNLTL--INCTS-DFVWLKWSPSPLPGGIVKVYSFKIHEHET 1285
Query: 4008 DPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHA--GEILSPWTLIQTLESS 4065
D T++ + G +A L GLEP +TY I V A G S T ES
Sbjct: 1286 D------TIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQESV 1339
Query: 4066 PSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSD-GFLEYSGLNRQFLFRRLDP 4124
P ++N + +++L++W P + NG+I Y + + + S + + F +L
Sbjct: 1340 PDVVQNMQC-MATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFIKLLA 1398
Query: 4125 FTLYTLTLEACTRAGCAHSAPQPLWT-DEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNG 4183
T Y + A T AG + + T E P V+STS L+W P G
Sbjct: 1399 NTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILG 1458
Query: 4184 KIIRYEVIR--RCFEGKAWGNQTIQADEKI--VFTEYNTERNTFMYNDTGLQPWTQCEYK 4239
Y++ R + K W ++ +KI ++ + TE + GL+ + ++
Sbjct: 1459 YFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVY-----GLKKFRWYRFQ 1513
Query: 4240 IYTWNSAGH-TCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNG----I 4294
+ +AG+ S+W +TL PP+G P + V+ +P + ISW P G +
Sbjct: 1514 VAASTNAGYGNASNWISTKTLPGPPDG-PPENVHVVATSPFSISISWSEPAVITGPTCYL 1572
Query: 4295 IQSYRLQRNEMLYPF---SFDPVTFNYTDEELLPFSTYSYALQACTSGGCS-------TS 4344
I + +E F + + T D E+ F+ YS + A T G S +S
Sbjct: 1573 IDVKSVDNDEFNISFIKSNEENKTIEIKDLEI--FTRYSVVITAFT-GNISAAYVEGKSS 1629
Query: 4345 KPTSITTLEAAPSEVSPPDLWAV-----SATQMNVCWSPPTVQNGKITKY---LVRYDNK 4396
+TTLE+AP + PP+ T+ + + PP+ NG I Y + R D+
Sbjct: 1630 AEMIVTTLESAPKD--PPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDP 1687
Query: 4397 ESLAGQGLCL----------LVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTME----A 4442
++ L + ++ L+ YN S+ A + G V TM+ A
Sbjct: 1688 TAVQIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGAGPKVPMRI-TMDIKAPA 1746
Query: 4443 LPENMDSPTLQVTGSESIEITWKPPRNP 4470
P+ +P TG + T R P
Sbjct: 1747 RPKTKPTPIYDATGKLLVTSTTITIRMP 1774
Score = 219 bits (558), Expect = 6e-56
Identities = 303/1227 (24%), Positives = 501/1227 (40%), Gaps = 121/1227 (9%)
Query: 1921 LQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVV 1980
L PFTE++ V A G RT P S+ + ++++ SI + WD P
Sbjct: 536 LVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIIN-YKNISSSSILLYWDPPEY 594
Query: 1981 -RGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAG 2039
G I Y + A D+ R ++ + F ++TGL + Y + + A T G
Sbjct: 595 PNGKITHYTIYAMELDTNRAFQITTIDNSF--------LITGLKKYTKYKMRVAASTHVG 646
Query: 2040 CTESSHALNI------STPQEAPQEVQPPVAKSLPSSLLLSWNPPKKANGIITQY-CLYM 2092
+ S +I P+ +PQ+V+ V + L W+PP+K NGII Y LY
Sbjct: 647 ESSLSEENDIFVRTSEDEPESSPQDVE--VIDVTADEIRLKWSPPEKPNGIIIAYEVLYK 704
Query: 2093 DGRLIY--SGSEENYTVTDLAVFTPHQFLLSACTHVGCTN--SSWVLLYTAQLPPEHVDS 2148
+ +Y + S + + +L T + + + T G N SS + + T++ P+
Sbjct: 705 NIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPE 764
Query: 2149 PVLTV-LDSRTIHIQWKQPRKISGILERYVLYM--SNHTHDFTIWSVIYNSTELFQDHML 2205
+ + S I + + P +GI+++Y +Y+ SN + TI N+T L Q+ +
Sbjct: 765 NITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTI-----NTTSLTQN--I 817
Query: 2206 QYVLPGNKYLIKLGACTGGGCTVSEAS-EALTDEDIPEGVPAP-KAHSYSPDSFNVSWTE 2263
+ + +Y+I++ A T G V A LT+ED P+ P S + +SW
Sbjct: 818 KVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQP 877
Query: 2264 PEYPNGVITSYGLYL---DGILIHNSSELSYRAYGFAPWSLHSFRVQACT--AKGCALGP 2318
P PNG+I Y +Y+ + N +E S +S V A T G
Sbjct: 878 PLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSN 937
Query: 2319 LVENRTLE-APPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGN- 2376
++ +T E AP + +V+ S + W P +PNG++ + ++Y + G
Sbjct: 938 IISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQ----YYSVYYRNTSGTF 993
Query: 2377 --NYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNS--QGSLITDPITIAMPP 2432
N+TL VT + + +ID L F+ YT + S S G+ +D I +
Sbjct: 994 MQNFTLHEVTNDF---DNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQ 1050
Query: 2433 GAPDGVLPP-RLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSA 2491
P+G + S + T++ V W PA+ N G Y + + +
Sbjct: 1051 DIPEGFVGNLTYESISSTAINVSWVPPAQPN--GLVFYYVSLILQQTPRHVRPPLVTYER 1108
Query: 2492 SLSYEVSDLQPYTEYMFRLVASN--GFGSAHSSWIPFMTAEDKP--GPVVPPILLDVKSR 2547
S+ ++ +L+ YT+Y+ ++ S GF +++ + T ED P P++ ++ S
Sbjct: 1109 SIYFD--NLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFK-NLSST 1165
Query: 2548 MMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGNVTNCTVMH-LHPYTAYKFQVEACTSK 2606
+L++W P K NG I Y++ L G + N ++ L P+T Y F A T K
Sbjct: 1166 SVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFFAAARTRK 1225
Query: 2607 GCSLSPES----QTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERR 2662
G L P S T ++P AP + L + T V + W P P G+V+ ++
Sbjct: 1226 G--LGPSSILFFYTDESVPLAPP--QNLTLINCTSDFVWLKWSPSPLPGGIVKVYSF--- 1278
Query: 2663 VKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNS-SAWVEVTTRP 2721
K E T + + K L P + Y RV T G N S V+ TT+
Sbjct: 1279 -KIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQE 1337
Query: 2722 SRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQKVT 2781
S P VQ +V V W PP NG I Y + + T V+
Sbjct: 1338 SVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVER---NSTKVSPQDHMYTFI 1394
Query: 2782 HLIPFTNYSVTIVAC-SGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVIS 2840
L+ T+Y + A S G G C S T T P+VP N+ V S + ++
Sbjct: 1395 KLLANTSYVFKVRASTSAGEGDESTCHVS--TLPETVPSVPTNIAFSDVQSTSAT---LT 1449
Query: 2841 WQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDK-------GLS 2893
W P G Y++ + Q E+ + I Q+LYE GL
Sbjct: 1450 WIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKI----QYLYEAHLTEETVYGLK 1505
Query: 2894 RFTTYEYMLFVHNSVGF-TPSREVTVTTLAGLPERGA-NLTASVLNHTAIDVRWAKPTVQ 2951
+F Y + + + G+ S ++ TL G P+ N+ + +I + W++P V
Sbjct: 1506 KFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISWSEPAV- 1564
Query: 2952 DLQGEVEYYTLFWSSATSNDSLKIL-----PDVNSHVIGHLKPNTEYWIFISVFNG---- 3002
+ G Y L + ND I + + I L+ T Y + I+ F G
Sbjct: 1565 -ITGPTCY--LIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTGNISA 1621
Query: 3003 --VHSINSAGLHATTCDGEPQGMLPPEVVIINS-----TAVRVIWTSPSNPNGVVTEYSI 3055
V +SA + TT + P+ PP + T ++ + PS PNG + Y
Sbjct: 1622 AYVEGKSSAEMIVTTLESAPKD--PPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQA 1679
Query: 3056 YVNNKLYKTGMNVPGSFILRDLSPFTI 3082
V + T + + I++ + F I
Sbjct: 1680 LVYREDDPTAVQIHNLSIIQKTNTFVI 1706
Score = 216 bits (549), Expect = 6e-55
Identities = 292/1226 (23%), Positives = 508/1226 (41%), Gaps = 158/1226 (12%)
Query: 2010 VNTSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKSLPS 2069
+ L+ ++ L+PF + ++++A T+ G + L++ T Q+ P ++ K++ S
Sbjct: 524 IAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPT-VLSVRTRQQVPSSIKIINYKNISS 582
Query: 2070 S-LLLSWNPPKKANGIITQYCLY---MDGRLIY--SGSEENYTVTDLAVFTPHQFLLSAC 2123
S +LL W+PP+ NG IT Y +Y +D + + + ++ +T L +T ++ ++A
Sbjct: 583 SSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAAS 642
Query: 2124 THVG---CTNSSWVLLYTAQLPPEHVDSPVLTV-LDSRTIHIQWKQPRKISGILERY-VL 2178
THVG + + + + T++ PE V + + + I ++W P K +GI+ Y VL
Sbjct: 643 THVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVL 702
Query: 2179 YMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACT--GGGCTVSEASEALT 2236
Y + T +Y D +L+ + P Y I + + T G G VS T
Sbjct: 703 YKNIDT--------LYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRT 754
Query: 2237 DEDIPEGVPAPKAH-SYSPDSFNVSWTEPEYPNGVITSYGLYL-----DGILIHNSSELS 2290
E +P+ P + + S +S+ P PNG+I Y +YL + N++ L+
Sbjct: 755 SETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLT 814
Query: 2291 YRAYGFAPWSLHSFRVQACTAKG-----CALGPLVENRTLEAPPEGTVNVFVKTQGSRKA 2345
++ + V A T KG + L E ++PP+ + VK
Sbjct: 815 QNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQ---DFSVKQLSGVTV 871
Query: 2346 HVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPF 2405
+ W+ P PNG++ ++Y V N +L + S E ++L D V +
Sbjct: 872 KLSWQPPLEPNGII--------LYYTVYVWNRSSLKTINVTETSLELSDL----DYNVEY 919
Query: 2406 TNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPR---LSSATPTSLQVVWSTPARNN 2462
+ Y V + G ++ I+ P GAP PP+ ++ + +S+ + W+ P++ N
Sbjct: 920 SAY-VTASTRFGDGKTRSNIISFQTPEGAPSD--PPKDVYYANLSSSSIILFWTPPSKPN 976
Query: 2463 APGSPRYQLQMRSGDST-------HGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASN- 2514
Y + R+ T H F N ++S + L ++ Y F L AS
Sbjct: 977 GI-IQYYSVYYRNTSGTFMQNFTLHEVTNDFDN--MTVSTIIDKLTIFSYYTFWLTASTS 1033
Query: 2515 -GFGSAHSSWIPFMTAEDKPGPVVPPILLD-VKSRMMLVTWQHPRKSNGVITHYNIYLHG 2572
G G+ S I T +D P V + + + S + V+W P + NG++ +Y
Sbjct: 1034 VGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYY----VS 1089
Query: 2573 RLYLRTPGNVTNCTVMH--------LHPYTAYKFQVEACTSKGCSLSPESQT-VWTLPGA 2623
+ +TP +V V + L YT Y ++ T KG S + +Q + T
Sbjct: 1090 LILQQTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDV 1149
Query: 2624 PEGIPSPELFSD-TPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMR 2682
PE P F + + TSV++SW PP PNG + ++ + ++G E + +T S +
Sbjct: 1150 PETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDL--TLQGPNENYSFIT---SDNYI 1204
Query: 2683 FIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQV 2742
+++ LSP+T Y + T G SS T A Q + D V +
Sbjct: 1205 ILEE---LSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWL 1261
Query: 2743 TWKPPLIQNG--DILSYEIHMPDPH-ITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSG- 2798
W P + G + S++IH + I N++ K+ L P + YS+ + A +
Sbjct: 1262 KWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKV 1321
Query: 2799 GNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLR 2858
GNG S TT +VP V + + S V++ W PP K NG +Y +
Sbjct: 1322 GNGN----QFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV-- 1375
Query: 2859 RKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTV 2918
+++ P+D +Y L T+Y + + S G V
Sbjct: 1376 -TVERNSTKVSPQD------------HMYTFIKLLANTSYVFKVRASTSAGEGDESTCHV 1422
Query: 2919 TTL-AGLPERGANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLF----------WSSA 2967
+TL +P N+ S + T+ + W +P + G + Y + W S
Sbjct: 1423 STLPETVPSVPTNIAFSDVQSTSATLTWIRP--DTILGYFQNYKITTQLRAQKCKEWESE 1480
Query: 2968 TSNDSLKILPDVNSHV----IGHLKPNTEYWIFISVFNGVHSINSAGLHAT-TCDGEPQG 3022
+ KI +H+ + LK Y ++ N++ +T T G P G
Sbjct: 1481 ECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDG 1540
Query: 3023 MLPPE---VVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNKLYKTGMNVPGSFI------ 3073
PPE VV + ++ + W+ P+ V+T + Y+ + SFI
Sbjct: 1541 --PPENVHVVATSPFSISISWSEPA----VITGPTCYLIDVKSVDNDEFNISFIKSNEEN 1594
Query: 3074 ----LRDLSPFTIYDIQV-----EVCTIYACVKSNGTQI-TTVEDTPSDIP-TPTIRGIT 3122
++DL FT Y + + + Y KS+ I TT+E P D P T + I
Sbjct: 1595 KTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIP 1654
Query: 3123 SR--SLQIDWVSPRKPNGIILGYDLL 3146
Q+ ++ P +PNG I Y L
Sbjct: 1655 DEVTKFQLTFLPPSQPNGNIQVYQAL 1680
Score = 212 bits (540), Expect = 7e-54
Identities = 299/1309 (22%), Positives = 520/1309 (39%), Gaps = 147/1309 (11%)
Query: 1921 LQPFTEYLYRV-IASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPV 1979
L+P+T YL+ V A+ E G Y D + RT + P+ P ++ G S + WD P
Sbjct: 273 LRPYTTYLFEVSAATTEAG--YIDSTIVRTPESVPEGPPQNCVTGNITGKSFSILWDPPT 330
Query: 1980 VRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAG 2039
+ Y ++ Y PS +T +L T L PF Y V + A T AG
Sbjct: 331 IVTGKFSYRVELYG---------PSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAG 381
Query: 2040 CTESSHALNISTPQEAPQEV-QPPVAKSLPSSLLLSWNPPKKANGIITQY---------C 2089
S+ +++ TP + P V +A+ + + ++W P++ NGII QY
Sbjct: 382 TGPKSN-ISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETG 440
Query: 2090 LYMDGRLIYSGSE---ENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHV 2146
+ ++ L+ +E + + + P L + S P ++
Sbjct: 441 IILENTLLTGNNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNF 500
Query: 2147 DSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQ 2206
P + +T + + + I+ I + Y+ FT
Sbjct: 501 --PARNRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFT------------------ 540
Query: 2207 YVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEY 2266
+++I + A T G T + +P + + S S + W PEY
Sbjct: 541 ------EHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEY 594
Query: 2267 PNGVITSYGLYLDGILIHNSSEL-----SYRAYGFAPWSLHSFRVQACTAKGCALGPLVE 2321
PNG IT Y +Y + + + ++ S+ G ++ + RV A T G L E
Sbjct: 595 PNGKITHYTIYAMELDTNRAFQITTIDNSFLITGLKKYTKYKMRVAASTHVG--ESSLSE 652
Query: 2322 N-----RTLEAPPEGT-VNVFVKTQGSRKAHVRWEAPFRPNG-LLTHSVLFTGIFYVDPV 2374
RT E PE + +V V + + ++W P +PNG ++ + VL+ I
Sbjct: 653 ENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPNGIIIAYEVLYKNI------ 706
Query: 2375 GNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNI------SNSQGSLITDPITI 2428
+Y + +++ L P T Y + V N SL++ +
Sbjct: 707 ----------DTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSE 756
Query: 2429 AMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSN 2488
+P AP+ + +SS +++ + P+ N +Y + ++ + E +
Sbjct: 757 TVPDSAPENITYKNISSG---EIELSFLPPSSPNGI-IQKYTIYLKRSNGN----EERTI 808
Query: 2489 PSASLSYEVSDLQPYTEYMFRLVASNGFG-SAHSSWIPFMTAEDKPGPVVPPILLDVKSR 2547
+ SL+ + L+ YT+Y+ + AS G S+ I +T ED P PP VK
Sbjct: 809 NTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDS--PPQDFSVKQL 866
Query: 2548 ---MMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPG-NVTNCTVMHLHPYTAYKFQVEAC 2603
+ ++WQ P + NG+I +Y +Y+ R L+T T+ + L Y V A
Sbjct: 867 SGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAYVTAS 926
Query: 2604 TSKGCSLSPESQTVWTLP-GAPEGIPSPELFSD-TPTSVIISWQPPTHPNGLVENFTI-E 2660
T G + + + P GAP P +++ + +S+I+ W PP+ PNG+++ +++
Sbjct: 927 TRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYY 986
Query: 2661 RRVKG--KEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHG-GTNSSAWVEV 2717
R G + T +M L+ ++ Y + + ST G G SS +EV
Sbjct: 987 RNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEV 1046
Query: 2718 TTRPSRPAG-VQPPVVTVLEPDAVQVTWKPPLIQNGDILSYE--IHMPDPHITLTNVTSA 2774
T P G V + A+ V+W PP NG + Y I P + +
Sbjct: 1047 YTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPPLVTY 1106
Query: 2775 VLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIP-LS 2833
S +L +T+Y + I S G+ T L Y+ T VP+ ++ LS
Sbjct: 1107 ERSIYFDNLEKYTDYILKITP-STEKGFSDTYTAQL--YIKTEEDVPETSPIINTFKNLS 1163
Query: 2834 ESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLS 2893
+ V++SW PP KPNG + Y+L +Q P N ++ + ++ ++ LS
Sbjct: 1164 STSVLLSWDPPVKPNGAIISYDL---TLQGP---------NENYSFITSDNYIILEE-LS 1210
Query: 2894 RFTTYEYMLFVHNSVGFTPSREVTVTTLAGLP-ERGANLTASVLNHTAIDVRWAKPTVQD 2952
FT Y + G PS + T +P NLT ++N T+ D W K +
Sbjct: 1211 PFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLT--LINCTS-DFVWLKWSPSP 1267
Query: 2953 LQGEVEYYTLFWSSATSNDSLKILP----DVNSHVIGHLKPNTEYWIFISVFNGVHSIN- 3007
L G + F D++ + ++G L+P + Y I +S F V + N
Sbjct: 1268 LPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVG-LEPVSTYSIRVSAFTKVGNGNQ 1326
Query: 3008 -SAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVNNKLYKTGM 3066
S + TT + P + + + + +V V W P NG++T+Y + V K
Sbjct: 1327 FSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSP 1386
Query: 3067 NVPGSFILRDLSPFTIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIPTP-TIRGITSRS 3125
+ L T Y +V T + ++T+ +T +PT + S S
Sbjct: 1387 Q-DHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTLPETVPSVPTNIAFSDVQSTS 1445
Query: 3126 LQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLVQDQSDELCKAVRCQ 3174
+ W+ P ILGY +K + QK + +S+E + + Q
Sbjct: 1446 ATLTWIRP----DTILGYFQNYKITTQ-LRAQKCKEWESEECVEYQKIQ 1489
Score = 204 bits (519), Expect = 2e-51
Identities = 249/1037 (24%), Positives = 429/1037 (41%), Gaps = 99/1037 (9%)
Query: 1948 RTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVV-RGVIEKYILKAYSEDSTRPPRMPSAS 2006
RT+ P S P ++++ IE+++ P G+I+KY + R
Sbjct: 753 RTSETVPDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYL--------KRSNGNE 804
Query: 2007 AEFVNTSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKS 2066
+NT++LT + L + Y + ++A TL G S ++I T ++AP PP S
Sbjct: 805 ERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDS--PPQDFS 862
Query: 2067 LPS----SLLLSWNPPKKANGIITQYCLYMDGRL---IYSGSEENYTVTDLAVFTPHQFL 2119
+ ++ LSW PP + NGII Y +Y+ R + +E + ++DL +
Sbjct: 863 VKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEYSAY 922
Query: 2120 LSACTHVGC--TNSSWVLLYTAQLPPEHVDSPVLTV-LDSRTIHIQWKQPRKISGILERY 2176
++A T G T S+ + T + P V L S +I + W P K +GI++ Y
Sbjct: 923 VTASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYY 982
Query: 2177 VLYMSNHT----HDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACT--GGGCTVSE 2230
+Y N + +FT+ V + + ++ + + Y L A T G G S+
Sbjct: 983 SVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSD 1042
Query: 2231 ASEALTDEDIPEGVPAPKAH-SYSPDSFNVSWTEPEYPNGVITSY-GLYLDGILIHN--- 2285
E TD+DIPEG + S S + NVSW P PNG++ Y L L H
Sbjct: 1043 IIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQQTPRHVRPP 1102
Query: 2286 --SSELSYRAYGFAPWSLHSFRVQACTAKGCA--LGPLVENRTLEAPPEGT--VNVFVKT 2339
+ E S ++ + ++ T KG + + +T E PE + +N F K
Sbjct: 1103 LVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTF-KN 1161
Query: 2340 QGSRKAHVRWEAPFRPNG-LLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVL 2398
S + W+ P +PNG ++++ + G NY+ + ++ +++
Sbjct: 1162 LSSTSVLLSWDPPVKPNGAIISYDLTLQG------PNENYSFIT----------SDNYII 1205
Query: 2399 IDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTP 2458
++ L PFT Y+ +G + + P + PP+ + + VW
Sbjct: 1206 LEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVP--LAPPQNLTLINCTSDFVWLKW 1263
Query: 2459 ARNNAPGS--PRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASN-- 2514
+ + PG Y ++ ++ + + S ++ L+P + Y R+ A
Sbjct: 1264 SPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEA--KLVGLEPVSTYSIRVSAFTKV 1321
Query: 2515 GFGSAHSSWIPFMTAEDKPGPVVPPILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHGRL 2574
G G+ S+ + F T E P V + + +LV W P+K+NG+IT Y + +
Sbjct: 1322 GNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNS 1381
Query: 2575 YLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFS 2634
+P + T + L T+Y F+V A TS G + V TLP +P+ FS
Sbjct: 1382 TKVSPQDHMY-TFIKLLANTSYVFKVRASTSAGEG-DESTCHVSTLPETVPSVPTNIAFS 1439
Query: 2635 DTP-TSVIISWQPPTHPNGLVENFTIERRVKGK-------EEVTTLVTLPRSHSMRFIDK 2686
D TS ++W P G +N+ I +++ + EE + + ++
Sbjct: 1440 DVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEE 1499
Query: 2687 TS-ALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPV-VTVLEPDAVQVTW 2744
T L + Y ++V ST G N+S W+ T P P G V V P ++ ++W
Sbjct: 1500 TVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISISW 1559
Query: 2745 KPPLIQNG------DILSYEIHMPDPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSG 2798
P + G D+ S + + +I+ + ++ L FT YSV I A +G
Sbjct: 1560 SEPAVITGPTCYLIDVKS--VDNDEFNISFIKSNEENKTIEIKDLEIFTRYSVVITAFTG 1617
Query: 2799 G--NGYLGG--CTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPNLRY 2854
Y+ G E + T + + P P N IP + +++ PPS+PNG Y
Sbjct: 1618 NISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVY 1677
Query: 2855 ELLRRKIQQPLASNPPEDLNRWHNI----YSGTQWLYEDKGLSRFTTYEYMLFVHNSVGF 2910
+ L + P A + HN+ + T + +GL TY ++ NS G
Sbjct: 1678 QALVYREDDPTAV-------QIHNLSIIQKTNTFVIAMLEGLKGGHTYNISVYAVNSAGA 1730
Query: 2911 TPSREVTVTTLAGLPER 2927
P + +T P R
Sbjct: 1731 GPKVPMRITMDIKAPAR 1747
Score = 190 bits (483), Expect = 3e-47
Identities = 288/1194 (24%), Positives = 472/1194 (39%), Gaps = 165/1194 (13%)
Query: 3460 SYTDVNLKPYMTYEYRISAWNSYGRG-LSKA--VRARTKEDVPQGVSPPTWTKIDNLEDT 3516
S+ LK Y Y+ R++A G LS+ + RT ED P+ SP ID D
Sbjct: 623 SFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPES-SPQDVEVIDVTADE 681
Query: 3517 IVLNWRKPIQSNGPIIYYILLRNGIER--FRGTSLSFSDKEGIQPFQEYSYQLKACTVAG 3574
I L W P + NG II Y +L I+ + TS + ++P Y+ +++ T G
Sbjct: 682 IRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFG 741
Query: 3575 CA--TSSKVVAATTQGVPESILPPSIT--ALSAVALHLSWSVPEKSNGVIKEYQI---RQ 3627
SS + T++ VP+S P +IT +S+ + LS+ P NG+I++Y I R
Sbjct: 742 HGNQVSSLLSVRTSETVPDS-APENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRS 800
Query: 3628 VGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAG-CTSSEPFLGQTLQAAPEGVWV 3686
G +TT Q+ + L+ YT Y ++A T G S P T + AP+
Sbjct: 801 NGNEERTINTTSLTQN-IKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQ 859
Query: 3687 TPRHIIINSTTVELYWSLPEKPNGLVSQYQL-SRNGNLLFLGGSEEQNFTDKNLEPNSRY 3745
++ TV+L W P +PNG++ Y + N + L E + +L+ N Y
Sbjct: 860 DFSVKQLSGVTVKLSWQPPLEPNGIILYYTVYVWNRSSLKTINVTETSLELSDLDYNVEY 919
Query: 3746 TYKLEVKT--GGGSSASDDYIVQTPMSTPEEIYPPYNI--TVIGPYSIFVAWIPP----G 3797
+ + T G G + S+ QTP P + PP ++ + SI + W PP G
Sbjct: 920 SAYVTASTRFGDGKTRSNIISFQTPEGAPSD--PPKDVYYANLSSSSIILFWTPPSKPNG 977
Query: 3798 ILIPEIPVEYNVLLNDGSVTPLAFSVGHH---------QSTLLENLTPFTQYEIRIQACQ 3848
I+ Y+V + S T + H ST+++ LT F+ Y + A
Sbjct: 978 II-----QYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTAST 1032
Query: 3849 NGSCGVSSRMFVK--TPEAAPMD-LNSPVLKALGSACIEIKWMPPEKPNGIIINY---FI 3902
+ G S ++ T + P + + +++ S I + W+PP +PNG++ Y +
Sbjct: 1033 SVGNGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLIL 1092
Query: 3903 YRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWS--LTQT 3960
+ P + V + E ++ F D L +T Y ++ KG ++ + +T
Sbjct: 1093 QQTPRHVRPPLVTY---ERSIYF----DNLEKYTDYILKITPSTEKGFSDTYTAQLYIKT 1145
Query: 3961 LEAPPQDFP-APWAQATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAF 4019
E P+ P + S+ SVLL+W P PNG I Y + Q ++ +F +
Sbjct: 1146 EEDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFIT------ 1199
Query: 4020 TVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKEN 4079
+ + L L PFT Y A G S T ES P +
Sbjct: 1200 ----SDNYIILEELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCT 1255
Query: 4080 GRALLLQWSEPMRTNGVIKTYNI-------FSDGFLEYSGLNRQFLFRRLDPFTLYTLTL 4132
+ L+WS G++K Y+ + + SG + L+P + Y++ +
Sbjct: 1256 SDFVWLKWSPSPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRV 1315
Query: 4133 EACTRAGCAH--SAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEV 4190
A T+ G + S T E+ PD + SV + W P NG I +Y V
Sbjct: 1316 SAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV 1375
Query: 4191 IRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTC 4250
T++ + V + MY L T +K+ SAG
Sbjct: 1376 -------------TVERNSTKVSPQ------DHMYTFIKLLANTSYVFKVRASTSAGEGD 1416
Query: 4251 SSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRN------- 4303
S V TL + P I++ + ++WI P+ G Q+Y++
Sbjct: 1417 ESTCHVSTLPETVPSV-PTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCK 1475
Query: 4304 --EMLYPFSFDPVTFNY----TDEE---LLPFSTYSYALQACTSGGC-STSKPTSITTLE 4353
E + + + Y T+E L F Y + + A T+ G + S S TL
Sbjct: 1476 EWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLP 1535
Query: 4354 AAPSEVSPPD---LWAVSATQMNVCWSPPTVQNGKITKYLV---RYDNKE------SLAG 4401
P PP+ + A S +++ WS P V G T YL+ DN E
Sbjct: 1536 GPPD--GPPENVHVVATSPFSISISWSEPAVITGP-TCYLIDVKSVDNDEFNISFIKSNE 1592
Query: 4402 QGLCLLVSHLQPYSQYNFSLVACTNGGCTA------SVSKSAWTMEALPEN-MDSPTLQV 4454
+ + + L+ +++Y+ + A T A S T+E+ P++ ++ T Q
Sbjct: 1593 ENKTIEIKDLEIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQK 1652
Query: 4455 TGSE--SIEITWKPPRNPNGQIRSYE-------------------LRRDGTIVYTGLETR 4493
E ++T+ PP PNG I+ Y+ +++ T V LE
Sbjct: 1653 IPDEVTKFQLTFLPPSQPNGNIQVYQALVYREDDPTAVQIHNLSIIQKTNTFVIAMLE-- 1710
Query: 4494 YRDFTLTPGVEYSYTVTASNSQGG---ILSPLVKDRTSPSAPSGMEPPKLQARG 4544
L G Y+ +V A NS G + + D +P+ P P A G
Sbjct: 1711 ----GLKGGHTYNISVYAVNSAGAGPKVPMRITMDIKAPARPKTKPTPIYDATG 1760
Score = 187 bits (476), Expect = 2e-46
Identities = 277/1188 (23%), Positives = 482/1188 (40%), Gaps = 145/1188 (12%)
Query: 2018 ILTGLLPFKNYAVTLTACTL-AGCTESSHALNISTPQEAPQEVQPP----VAKSLPSSLL 2072
++T L P+ Y ++A T AG +S+ + TP+ P+ PP S
Sbjct: 269 VVTHLRPYTTYLFEVSAATTEAGYIDSTI---VRTPESVPEG--PPQNCVTGNITGKSFS 323
Query: 2073 LSWNPPKKANGIITQYC-LY-MDGRLIYSGSEE-NYTVTDLAVFTPHQFLLSACTHVGCT 2129
+ W+PP G + LY GR++ + +++ + T+L FT + ++A T G
Sbjct: 324 ILWDPPTIVTGKFSYRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTG 383
Query: 2130 NSSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERY-VLYMSNHTHDFT 2188
S + ++T P V L ++S + I WK+PR+ +GI+ +Y V + T
Sbjct: 384 PKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGIIL 443
Query: 2189 IWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPK 2248
+++ + E D M ++ + ++ L G +S +L A
Sbjct: 444 ENTLLTGNNEYINDPMAPEIVNIVEPMVGLYE---GSAEMSSDLHSL----------ATF 490
Query: 2249 AHSYSPD-SFNVSWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLHSFRVQ 2307
++ PD +F + + V+T+ Y+ I + +LSY P++ H V
Sbjct: 491 IYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIA---AEQLSYVIRRLVPFTEHMISVS 547
Query: 2308 ACTAKGCALGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLF-- 2365
A T G ++ RT + P + K S + W+ P PNG +TH ++
Sbjct: 548 AFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAM 607
Query: 2366 ----TGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQG-S 2420
F + + N++ LI GL +T Y ++V S G S
Sbjct: 608 ELDTNRAFQITTIDNSF-------------------LITGLKKYTKYKMRVAASTHVGES 648
Query: 2421 LITDPITIAM------PPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMR 2474
+++ I + P +P V + T +++ WS P + N Y++ +
Sbjct: 649 SLSEENDIFVRTSEDEPESSPQDV---EVIDVTADEIRLKWSPPEKPNGI-IIAYEVLYK 704
Query: 2475 SGDSTHGFLELFSNPSASLSYEVSDLQPYTEY--MFRLVASNGFGSAHSSWIPFMTAEDK 2532
+ D+ L+ +++ + +L+P+T Y R G G+ SS + T+E
Sbjct: 705 NIDT------LYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETV 758
Query: 2533 PGPVVPPILL-DVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPG------NVTNC 2585
P I ++ S + +++ P NG+I Y IYL R+ G N T+
Sbjct: 759 PDSAPENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLK-----RSNGNEERTINTTSL 813
Query: 2586 T--VMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSP-ELFSDTPTSVII 2642
T + L YT Y +V A T KG + ++ T AP+ P + + +V +
Sbjct: 814 TQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKL 873
Query: 2643 SWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLM 2702
SWQPP PNG++ +T+ V + + T+ S + +D +Y V
Sbjct: 874 SWQPPLEPNGIILYYTV--YVWNRSSLKTINVTETSLELSDLDYN------VEYSAYVTA 925
Query: 2703 STLHG-GTNSSAWVEVTTRPSRPAGVQPPVVTV-LEPDAVQVTWKPPLIQNGDILSYEIH 2760
ST G G S + T P+ V L ++ + W PP NG I Y ++
Sbjct: 926 STRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVY 985
Query: 2761 MPD------PHITLTNVT----SAVLSQKVTHLIPFTNYSVTIVA-CSGGNGYLGGCTES 2809
+ + TL VT + +S + L F+ Y+ + A S GNG ++
Sbjct: 986 YRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNG--NKSSDI 1043
Query: 2810 LPTYVTTHPTVPQN-VGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASN 2868
+ Y T +P+ VG L+ +S + + +SW PP++PNG Y L + Q P
Sbjct: 1044 IEVY--TDQDIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQ-QTPRHVR 1100
Query: 2869 PPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGF--TPSREVTVTTLAGLPE 2926
PP + + + +Y D L ++T Y + GF T + ++ + T +PE
Sbjct: 1101 PP--------LVTYERSIYFD-NLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE 1151
Query: 2927 RGANL-TASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIG 2985
+ T L+ T++ + W P + G + Y L + N++ + N ++
Sbjct: 1152 TSPIINTFKNLSSTSVLLSWDPPVKPN--GAIISYDL--TLQGPNENYSFITSDNYIILE 1207
Query: 2986 HLKPNTEYWIFISVFNGVHSINSAGLHATTCDGEPQGMLPPE-VVIINSTA--VRVIWTS 3042
L P T Y F + S+ L T + P + PP+ + +IN T+ V + W+
Sbjct: 1208 ELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVP--LAPPQNLTLINCTSDFVWLKWSP 1265
Query: 3043 PSNPNGVVTEYSIYVNNK-----LYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYACVK 3097
P G+V YS ++ YK L L P + Y I+V T
Sbjct: 1266 SPLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGN 1325
Query: 3098 --SNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGY 3143
SN + TT E P + + +S+ + W P+K NGII Y
Sbjct: 1326 QFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQY 1373
Score = 183 bits (465), Expect = 3e-45
Identities = 294/1264 (23%), Positives = 483/1264 (38%), Gaps = 149/1264 (11%)
Query: 1921 LQPFTEYLYRVIASHEGG-SVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEP- 1978
L P T Y +V A + G V+SD +T +AP V + V + N ++++ W P
Sbjct: 121 LNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLT-VEAYNASAVKLIWYLPR 179
Query: 1979 VVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLA 2038
G I + + S + S E ILTG LP
Sbjct: 180 QPNGKITSFKISVKHARSGIVVKDVSIRVE--------DILTGKLP-------------- 217
Query: 2039 GCTESSHALNISTPQEAPQ--EVQPPVAKSLPSSLLLS------WNPPKKANGIITQYCL 2090
C E+S + ST +P V PP + SS L W P
Sbjct: 218 ECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPI----------- 266
Query: 2091 YMDGRLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPV 2150
++ VT L +T + F +SA T S ++ +P + V
Sbjct: 267 -------------SFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVRTPESVPEGPPQNCV 313
Query: 2151 LTVLDSRTIHIQWKQPRKISGILE-RYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVL 2209
+ ++ I W P ++G R LY + ++ NST+ + +
Sbjct: 314 TGNITGKSFSILWDPPTIVTGKFSYRVELYGPSGR-------ILDNSTKDLK-FAFTNLT 365
Query: 2210 PGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNG 2269
P Y + + A T G T D+P V + ++W +P PNG
Sbjct: 366 PFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNG 425
Query: 2270 VITSYGLYL----DGILIHNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPLVENRTL 2325
+I Y + + GI++ N+ Y P + + + P+V
Sbjct: 426 IINQYRVKVLVPETGIILENTLLTGNNEYINDPMAPEIVNI---------VEPMV--GLY 474
Query: 2326 EAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGL-LTHSVLFTGIFYVDPVGNNYTLLNVT 2384
E E + ++ +H P R T V+ T Y+ +
Sbjct: 475 EGSAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIA--------- 525
Query: 2385 KVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLS 2444
L +I LVPFT + + V+ G +++ P +
Sbjct: 526 -------AEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYK 578
Query: 2445 SATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYT 2504
+ + +S+ + W P N Y + D+ F + S+ ++ L+ YT
Sbjct: 579 NISSSSILLYWDPPEYPNGK-ITHYTIYAMELDTNRA----FQITTIDNSFLITGLKKYT 633
Query: 2505 EYMFRLVASNGFGSAHSSW---IPFMTAEDKPGPVVPPI-LLDVKSRMMLVTWQHPRKSN 2560
+Y R+ AS G + S I T+ED+P + ++DV + + + W P K N
Sbjct: 634 KYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPN 693
Query: 2561 GVITHYNIYLHG--RLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPES---- 2614
G+I Y + LY++ + T+ + +L P+T Y V + T G S
Sbjct: 694 GIIIAYEVLYKNIDTLYMKNT-STTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSV 752
Query: 2615 QTVWTLP-GAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLV 2673
+T T+P APE I + S + +S+ PP+ PNG+++ +TI + E T+
Sbjct: 753 RTSETVPDSAPENITYKNISSG---EIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTIN 809
Query: 2674 TLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRP-AGVQPPVV 2732
T + +++ + K +T+Y V STL G SA + + T P + Q V
Sbjct: 810 TTSLTQNIKVLKK------YTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSV 863
Query: 2733 TVLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQKVTHLIPFTNYSVT 2792
L V+++W+PPL NG IL Y +++ + +L + S +++ L YS
Sbjct: 864 KQLSGVTVKLSWQPPLEPNGIILYYTVYVWN-RSSLKTINVTETSLELSDLDYNVEYSAY 922
Query: 2793 IVACSG-GNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPN 2851
+ A + G+G S T P++V LS S +++ W PPSKPNG
Sbjct: 923 VTASTRFGDGKTRSNIISFQTPEGAPSDPPKDV---YYANLSSSSIILFWTPPSKPNGII 979
Query: 2852 LRYELLRRKIQQPLASN--PPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSV- 2908
Y + R N E N + N+ T DK L+ F+ Y + L SV
Sbjct: 980 QYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVST---IIDK-LTIFSYYTFWLTASTSVG 1035
Query: 2909 -GFTPSREVTVTTLAGLPER-GANLTASVLNHTAIDVRWAKPTVQDLQGEVEYY-TLFWS 2965
G S + V T +PE NLT ++ TAI+V W P + G V YY +L
Sbjct: 1036 NGNKSSDIIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQPN--GLVFYYVSLILQ 1093
Query: 2966 SATSNDSLKILPDVNSHVIGHLKPNTEYWIFI--SVFNGVHSINSAGLHATTCDGEPQ-G 3022
+ ++ S +L+ T+Y + I S G +A L+ T + P+
Sbjct: 1094 QTPRHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETS 1153
Query: 3023 MLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYVN--NKLYKTGMNVPGSFILRDLSPF 3080
+ ++ST+V + W P PNG + Y + + N+ Y + + IL +LSPF
Sbjct: 1154 PIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENY-SFITSDNYIILEELSPF 1212
Query: 3081 TIYDIQVEVCTIYACVKSNGTQITTVEDTPSDIP-TPTIRGITSRSLQIDWVSPRKPNGI 3139
T+Y T S+ T E P P T+ TS + + W P GI
Sbjct: 1213 TLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLPGGI 1272
Query: 3140 ILGY 3143
+ Y
Sbjct: 1273 VKVY 1276
Score = 181 bits (458), Expect = 2e-44
Identities = 259/1078 (24%), Positives = 409/1078 (37%), Gaps = 142/1078 (13%)
Query: 3921 GALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAP-PQDFPAPWAQATSAH 3979
G E + + P T Y+ + + ++ + +T + P P F A + +
Sbjct: 13 GTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLA--GERVGSA 70
Query: 3980 SVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTY 4039
+LL+W P +PNG I Y V Y+E + K S + L L P TTY
Sbjct: 71 GILLSWNTPPNPNGRIISYIVKYKE---VCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTY 127
Query: 4040 RIGVVAANHAG-EILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIK 4098
I V A N AG + S L QT ES+P + N VE N A+ L W P + NG I
Sbjct: 128 EIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVE-AYNASAVKLIWYLPRQPNGKIT 186
Query: 4099 TYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAP---- 4154
++ I SG+ + + R++ L C ++ LW+ +P
Sbjct: 187 SFKISVKH--ARSGIVVKDVSIRVEDILTGKL-------PECNENSESFLWSTASPSPTL 237
Query: 4155 ----PDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEK 4210
P S+ + ++ + W EP++
Sbjct: 238 GRVTPPSRTTHSSSTLTQNEISSVWKEPIS------------------------------ 267
Query: 4211 IVFTEYNTERNTFMYNDTGLQPWTQCEYKI-YTWNSAGHTCSSWNVVRTLQAPPEGLSPP 4269
+ T L+P+T +++ AG+ S+ +VRT ++ PEG P
Sbjct: 268 --------------FVVTHLRPYTTYLFEVSAATTEAGYIDST--IVRTPESVPEG-PPQ 310
Query: 4270 VISYVSMNPQKLLISWIPPEQSNGIIQSYRLQ---RNEMLYPFSFDPVTFNYTDEELLPF 4326
++ + I W PP G SYR++ + + S + F +T+ L PF
Sbjct: 311 NCVTGNITGKSFSILWDPPTIVTGKF-SYRVELYGPSGRILDNSTKDLKFAFTN--LTPF 367
Query: 4327 STYSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKI 4386
+ Y + A TS G S+ T P V L V +TQ+ + W P NG I
Sbjct: 368 TMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGII 427
Query: 4387 TKYLVRYDNKESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPEN 4446
+Y V+ E+ G+ L + L ++Y N + M L E
Sbjct: 428 NQYRVKVLVPET----GIILENTLLTGNNEY-------INDPMAPEIVNIVEPMVGLYEG 476
Query: 4447 MDSPTLQVTGSESIEITWKPPRNPNGQIRSYE-------LRRDGTIVYTGLETRYRDFTL 4499
+ + + P +N + R+ + R + Y L
Sbjct: 477 SAEMSSDLHSLATFIYNSHPDKNFPARNRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRL 536
Query: 4500 TPGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTN 4559
P E+ +V+A G ++ RT PS ++ + IL+ WDPP N
Sbjct: 537 VPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPN 596
Query: 4560 GDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCAS 4619
G I +YT++ EL + I T NSF ++ LK + +Y++R+ A T +G +S
Sbjct: 597 GKITHYTIYAMEL--DTNRAFQITTIDNSF-----LITGLKKYTKYKMRVAASTHVGESS 649
Query: 4620 ---SDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQ 4676
+ F++T E P P + + + L W+ P +PNG ++ YE+ +
Sbjct: 650 LSEENDIFVRTSEDEPESSPQDVEVIDVT----ADEIRLKWSPPEKPNGIIIAYEVLYKN 705
Query: 4677 IATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVN--SAGKAPSSWTWCRTGPAP 4734
I T + + N S+T I L P T Y V + G SS RT
Sbjct: 706 IDT-------LYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETV 758
Query: 4735 PEGLRAP---TFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQT 4791
P+ AP T+ ISS + ++ P PNGI+ Y ++ ++G E + Q
Sbjct: 759 PDS--APENITYKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQN 816
Query: 4792 LHGLQAFTNYSIGVEACTC-FNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWS 4850
+ L+ +T Y I V A T P + L AP S + L+ T W
Sbjct: 817 IKVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQ 876
Query: 4851 PPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVV 4910
PP+ PNG+I L + V S+L I T L L L Y V
Sbjct: 877 PPLEPNGII----LYYTVYVWNRSSL----KTINVTETSL----ELSDLDYNVEYSAYVT 924
Query: 4911 AHNEV--GSTASEWISFTTQKELPQYRAPFSVDSNL--SVVCVNWSDTFLLNGQLKEY 4964
A G T S ISF T + P +NL S + + W+ NG ++ Y
Sbjct: 925 ASTRFGDGKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYY 982
Score = 137 bits (345), Expect = 3e-31
Identities = 215/1001 (21%), Positives = 385/1001 (38%), Gaps = 201/1001 (20%)
Query: 2208 VLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKA-HSYSPDSFNVSWTEPEY 2266
V+PG +Y I + + + S + +T G P A +SW P
Sbjct: 24 VVPGTRYDITISSIST--TYTSPVTRIVTTNVTKPGPPVFLAGERVGSAGILLSWNTPPN 81
Query: 2267 PNGVITSYGLYLDGI----------LIHNSSELSYRAYGFAPWSLHSFRVQACTAKGCAL 2316
PNG I SY + + + L P + + +V A + G +
Sbjct: 82 PNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAENSAGIGV 141
Query: 2317 --GPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPV 2374
P + +T E+ P VN+ V+ + + W P +PNG +T
Sbjct: 142 FSDPFLF-QTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKIT-------------- 186
Query: 2375 GNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGA 2434
+ ++++ +++ ++ ++I +
Sbjct: 187 ----------------------------------SFKISVKHARSGIVVKDVSIRV---- 208
Query: 2435 PDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLS 2494
+ +L +L S +WST + + G + ST E+ S +S
Sbjct: 209 -EDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNEISSVWKEPIS 267
Query: 2495 YEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAEDKP-GPVVPPILLDVKSRMMLVTW 2553
+ V+ L+PYT Y+F + A+ S I T E P GP + ++ + + W
Sbjct: 268 FVVTHLRPYTTYLFEVSAATTEAGYIDSTI-VRTPESVPEGPPQNCVTGNITGKSFSILW 326
Query: 2554 QHPRKSNGVITHYNIYLHG--RLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLS 2611
P G + Y + L+G L +L P+T Y + A TS G
Sbjct: 327 DPPTIVTGKFS-YRVELYGPSGRILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAG--TG 383
Query: 2612 PESQ-TVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVT 2670
P+S +V+T P P + +L T V I+W+ P PNG++ + ++
Sbjct: 384 PKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVK---------- 433
Query: 2671 TLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPP 2730
V +P + +L +TL G N E P + P
Sbjct: 434 --VLVPETGI-------------------ILENTLLTGNN-----EYINDP-----MAPE 462
Query: 2731 VVTVLEPDAVQVTWKPPLIQNGDILS-----YEIHMPD--------------PHIT---- 2767
+V ++EP + ++ + D+ S Y H PD P +T
Sbjct: 463 IVNIVEP--MVGLYEGSAEMSSDLHSLATFIYNSH-PDKNFPARNRAEDQTSPVVTTRNQ 519
Query: 2768 -LTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTY--VTTHPTVPQNV 2824
+T++ + LS + L+PFT + +++ A + +G E PT V T VP ++
Sbjct: 520 YITDIAAEQLSYVIRRLVPFTEHMISVSAFT----IMG---EGPPTVLSVRTRQQVPSSI 572
Query: 2825 GPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQ 2884
++ +S S +++ W PP PNG Y + ++ D NR I +
Sbjct: 573 KIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMEL----------DTNRAFQI-TTID 621
Query: 2885 WLYEDKGLSRFTTYEYMLFVHNSVG---FTPSREVTVTTLAGLPERGANLTASVLNHTAI 2941
+ GL ++T Y+ + VG + ++ V T PE V++ TA
Sbjct: 622 NSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQ-DVEVIDVTAD 680
Query: 2942 DVR--WA---KPTVQDLQGEVEYY---TLFWSSATSNDSLKILPDVNSHVIGHLKPNTEY 2993
++R W+ KP + EV Y TL+ + ++ D ++ +L+P+T Y
Sbjct: 681 EIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTDI----------ILRNLRPHTLY 730
Query: 2994 WIFISVF------NGVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPN 3047
I + + N V S+ S T D P+ + I+S + + + PS+PN
Sbjct: 731 NISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKN---ISSGEIELSFLPPSSPN 787
Query: 3048 GVVTEYSIYV---NNKLYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYA-CVKSNGTQI 3103
G++ +Y+IY+ N +T + ++ L +T Y I+V T+ V+S I
Sbjct: 788 GIIQKYTIYLKRSNGNEERTINTTSLTQNIKVLKKYTQYIIEVSASTLKGEGVRSAPISI 847
Query: 3104 TTVEDTPSDIPTP-TIRGITSRSLQIDWVSPRKPNGIILGY 3143
T ED P P +++ ++ ++++ W P +PNGIIL Y
Sbjct: 848 LTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGIILYY 888
Score = 122 bits (306), Expect = 9e-27
Identities = 169/740 (22%), Positives = 284/740 (38%), Gaps = 115/740 (15%)
Query: 2482 FLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAED--KPGPVVPP 2539
FL LF S + +VS++ P T Y + + + ++S + + + KPGP V
Sbjct: 7 FLLLFIGTSET-QVDVSNVVPGTRYDITI---SSISTTYTSPVTRIVTTNVTKPGPPVFL 62
Query: 2540 ILLDVKSRMMLVTWQHPRKSNGVITHYNIYLHG--------RLYLRTPGNVTNCTVMHLH 2591
V S +L++W P NG I Y + +R+ + + +L+
Sbjct: 63 AGERVGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLN 122
Query: 2592 PYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPN 2651
P T Y+ +V A S G + + T AP + + + + ++V + W P PN
Sbjct: 123 PGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPN 182
Query: 2652 GLVENFTIERR------------VKGKEEVTTLVTLPRSHSMRFIDKTSA---------- 2689
G + +F I + ++ ++ +T + +S F+ T++
Sbjct: 183 GKITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTP 242
Query: 2690 ------------------------------LSPWTKYEYRVLMSTLHGGTNSSAWVEVTT 2719
L P+T Y + V +T G S V T
Sbjct: 243 PSRTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSAATTEAGYIDSTIVR--T 300
Query: 2720 RPSRPAGVQPPVVT-VLEPDAVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQ 2778
S P G VT + + + W PP I G SY + + P + + ++ L
Sbjct: 301 PESVPEGPPQNCVTGNITGKSFSILWDPPTIVTGK-FSYRVELYGPSGRILDNSTKDLKF 359
Query: 2779 KVTHLIPFTNYSVTIVA-CSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYV 2837
T+L PFT Y V I A S G G + V T P VP V L + + + V
Sbjct: 360 AFTNLTPFTMYDVYIAAETSAGTGPKSNIS------VFTPPDVPGAVFDLQLAEVESTQV 413
Query: 2838 VISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTT 2897
I+W+ P +PNG +Y R K+ P E + + +G D
Sbjct: 414 RITWKKPRQPNGIINQY---RVKVLVPETGIILE-----NTLLTGNNEYINDP------- 458
Query: 2898 YEYMLFVHNSVGFTPSREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQ-DLQGE 2956
P V + GL E A + +S L+ A + + P +
Sbjct: 459 ------------MAPEIVNIVEPMVGLYEGSAEM-SSDLHSLATFIYNSHPDKNFPARNR 505
Query: 2957 VEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNTEYWIFISVFNGVHSINSAGLHATTC 3016
E T + + I + S+VI L P TE+ I +S F + L T
Sbjct: 506 AEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTR 565
Query: 3017 DGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSIYV----NNKLYKTGMNVPGSF 3072
P + I+S+++ + W P PNG +T Y+IY N+ ++ + SF
Sbjct: 566 QQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQI-TTIDNSF 624
Query: 3073 ILRDLSPFTIYDIQVEVCTIY---ACVKSNGTQITTVEDTPSDIPTPT-IRGITSRSLQI 3128
++ L +T Y ++V T + + N + T ED P P + +T+ +++
Sbjct: 625 LITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRL 684
Query: 3129 DWVSPRKPNGIILGYDLLWK 3148
W P KPNGII+ Y++L+K
Sbjct: 685 KWSPPEKPNGIIIAYEVLYK 704
Score = 97.4 bits (241), Expect = 3e-19
Identities = 122/467 (26%), Positives = 200/467 (42%), Gaps = 81/467 (17%)
Query: 1066 SSSAINLSWSPPDSPNA---HWLTYSLLRD---GFEIYTTEDQYPYSIQYFLDTDLLPYT 1119
SSS+I L W PP+ PN H+ Y++ D F+I T ++ FL T L YT
Sbjct: 581 SSSSILLYWDPPEYPNGKITHYTIYAMELDTNRAFQITTIDNS-------FLITGLKKYT 633
Query: 1120 KYSYYIE-TTNVHGSTRSVA--VTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQS 1176
KY + +T+V S+ S + +T PE + +I + +D + L W+ +
Sbjct: 634 KYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADEIRLKWSPPEKPN 693
Query: 1177 GPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGG------CLH 1230
G I Y + + T + NL P Y+ SV++ T G L
Sbjct: 694 GIIIAYEVLYKNI---DTLYMKNTSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLL 750
Query: 1231 SLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETT 1290
S+ + T + P+ ++ + ISS E+ + + PP+ NGII +Y +Y++R +E T
Sbjct: 751 SVRTSETVPDSAPENIT---YKNISSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERT 807
Query: 1291 SEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SVS 1349
+ + Q+ I L+ YT+Y V A + G V
Sbjct: 808 INTTSLTQN--------------------------IKVLKKYTQYIIEVSASTLKGEGVR 841
Query: 1350 SAWVSERTGESAPVFMIPP---SVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQS 1406
SA +S T E AP PP SV LS ++ +SW+ P + G ++ Y + + + +S
Sbjct: 842 SAPISILTEEDAP--DSPPQDFSVKQLSGVTVKLSWQPPLE--PNGIILYYTVYVWN-RS 896
Query: 1407 PQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASG--AGQTLA 1464
++I + + L + +L Y VE Y +T G + S + QT
Sbjct: 897 SLKTINVTETSL----ELSDLDYNVE-------YSAYVTASTRFGDGKTRSNIISFQTPE 945
Query: 1465 AAPAQLRPP---LVKGINSTTIHLKWFPPEELNGPSPIYQLERRESS 1508
AP+ PP ++S++I L W PP + NG Y + R +S
Sbjct: 946 GAPSD--PPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTS 990
Score = 93.6 bits (231), Expect = 5e-18
Identities = 155/689 (22%), Positives = 265/689 (38%), Gaps = 106/689 (15%)
Query: 1913 EQSVYEGGLQPFTEYLYRVIASHEGG--SVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYS 1970
E+S+Y L+ +T+Y+ ++ S E G Y+ +T P++ P + ++L+ S
Sbjct: 1107 ERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLSSTS 1166
Query: 1971 IEVTWDEPV-VRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYA 2029
+ ++WD PV G I Y L P+ + F+ + N IL L PF Y+
Sbjct: 1167 VLLSWDPPVKPNGAIISYDLTLQG---------PNENYSFITSDNYI-ILEELSPFTLYS 1216
Query: 2030 VTLTACTLAGCTESS---HALNISTPQEAPQEVQPPVAKSLPSSLLLSWNPPKKANGIIT 2086
A T G SS + S P PQ + + + L W+P GI+
Sbjct: 1217 FFAAARTRKGLGPSSILFFYTDESVPLAPPQNL--TLINCTSDFVWLKWSPSPLPGGIVK 1274
Query: 2087 QYCLYM---DGRLIY----SGSEENYTVTDLAVFTPHQFLLSACTHVGCTN--SSWVLLY 2137
Y + + IY SG + + L + + +SA T VG N S+ V
Sbjct: 1275 VYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFT 1334
Query: 2138 TAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIWSVIYNST 2197
T + P+ V + +++ ++W P+K +GI+ +Y++ +V NST
Sbjct: 1335 TQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV------------TVERNST 1382
Query: 2198 ELF-QDHMLQYV--LPGNKYLIKLGACTGGGCTVSEASEALTD-EDIPEGVPAPKAHSYS 2253
++ QDHM ++ L Y+ K+ A T G E E+ +PE VP+ +
Sbjct: 1383 KVSPQDHMYTFIKLLANTSYVFKVRASTSAG----EGDESTCHVSTLPETVPSVPTNIAF 1438
Query: 2254 PD----SFNVSWTEPEYPNGVITSYGL-------------------YLDGILIHNSSELS 2290
D S ++W P+ G +Y + Y ++ +
Sbjct: 1439 SDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTE 1498
Query: 2291 YRAYGFAPWSLHSFRVQACTAKGCA-LGPLVENRTLEAPPEG-TVNVFVKTQGSRKAHVR 2348
YG + + F+V A T G + +TL PP+G NV V +
Sbjct: 1499 ETVYGLKKFRWYRFQVAASTNAGYGNASNWISTKTLPGPPDGPPENVHVVATSPFSISIS 1558
Query: 2349 WEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNY 2408
W P ++T + + V V N+ ++ K E N + I L FT Y
Sbjct: 1559 WSEP----AVITGPTCY--LIDVKSVDNDEFNISFIK----SNEENKTIEIKDLEIFTRY 1608
Query: 2409 TVQV-----NISNS--QGSLITDPI--TIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPA 2459
+V + NIS + +G + I T+ P P + + T Q+ + P+
Sbjct: 1609 SVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPS 1668
Query: 2460 RNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSA 2519
+ N L R D P+A + +S +Q ++ ++ G
Sbjct: 1669 QPNGNIQVYQALVYREDD-----------PTAVQIHNLSIIQKTNTFVIAML--EGLKGG 1715
Query: 2520 HSSWIPFMTAEDK-PGPVVP-PILLDVKS 2546
H+ I GP VP I +D+K+
Sbjct: 1716 HTYNISVYAVNSAGAGPKVPMRITMDIKA 1744
Score = 88.6 bits (218), Expect = 1e-16
Identities = 137/627 (21%), Positives = 250/627 (39%), Gaps = 83/627 (13%)
Query: 1864 KDVKFTRGAVVNLASVSSGAVRVNLDGCLSTDSAV-----NCRGNDSILVYQGKEQSVYE 1918
+DV T + ++SS +V ++ D + + A+ +G + + + +
Sbjct: 1147 EDVPETSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQGPNENYSFITSDNYIIL 1206
Query: 1919 GGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWD-E 1977
L PFT Y + A G S T + P + P + + + + W
Sbjct: 1207 EELSPFTLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPS 1266
Query: 1978 PVVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGI-----LTGLLPFKNYAVTL 2032
P+ G+++ Y K + ++ + + N++G L GL P Y++ +
Sbjct: 1267 PLPGGIVKVYSFKIHEHET-----------DTIYYKNISGFKTEAKLVGLEPVSTYSIRV 1315
Query: 2033 TACTLAGC-TESSHALNISTPQEAPQEVQPPVAKSLP-SSLLLSWNPPKKANGIITQYCL 2090
+A T G + S+ + +T + P VQ + S+L+ W+PPKKANGIITQY +
Sbjct: 1316 SAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMV 1375
Query: 2091 YMD-GRLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSP 2149
++ S + YT L T + F + A T G + S + T PE V S
Sbjct: 1376 TVERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHVSTL---PETVPSV 1432
Query: 2150 VLTV----LDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIWS----VIYNSTE-LF 2200
+ + S + + W +P I G + Y + W V Y + L+
Sbjct: 1433 PTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEYQKIQYLY 1492
Query: 2201 QDHMLQYVLPGNK----YLIKLGACTGGGCTVSEASEALTDEDIPEGVPAPKAHSY---- 2252
+ H+ + + G K Y ++ A T G AS ++ + +P P + +
Sbjct: 1493 EAHLTEETVYGLKKFRWYRFQVAASTNAG--YGNASNWISTKTLPGPPDGPPENVHVVAT 1550
Query: 2253 SPDSFNVSWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYG---------------FA 2297
SP S ++SW+EP VIT YL + ++ E + F
Sbjct: 1551 SPFSISISWSEP----AVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDLEIFT 1606
Query: 2298 PWSL----HSFRVQACTAKGCALGPLVENRTLEAPPEGTVN--VFVKTQGS-RKAHVRWE 2350
+S+ + + A +G + ++ TLE+ P+ N F K K + +
Sbjct: 1607 RYSVVITAFTGNISAAYVEGKSSAEMIVT-TLESAPKDPPNNMTFQKIPDEVTKFQLTFL 1665
Query: 2351 APFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWV--LIDGLVPFTNY 2408
P +PNG + ++ + Y + + N++ + ++TN +V +++GL Y
Sbjct: 1666 PPSQPNGNIQ---VYQALVYREDDPTAVQIHNLSII----QKTNTFVIAMLEGLKGGHTY 1718
Query: 2409 TVQVNISNSQGSLITDPITIAMPPGAP 2435
+ V NS G+ P+ I M AP
Sbjct: 1719 NISVYAVNSAGAGPKVPMRITMDIKAP 1745
Score = 77.0 bits (188), Expect = 4e-13
Identities = 109/483 (22%), Positives = 185/483 (38%), Gaps = 67/483 (13%)
Query: 1066 SSSAINLSWSPPDSPNAHWLTYSL--------LRDGFEIYTTEDQYPYSIQYFLDTDLLP 1117
SSS+I L W+PP PN YS+ F ++ + + + L
Sbjct: 961 SSSSIILFWTPPSKPNGIIQYYSVYYRNTSGTFMQNFTLHEVTNDFDNMTVSTIIDKLTI 1020
Query: 1118 YTKYSYYI--ETTNVHGSTRSVAVTYKTKPGVPEG---NLTLSYIIPIGSDSVTLTWTTL 1172
++ Y++++ T+ +G+ S + T +PEG NLT I S ++ ++W
Sbjct: 1021 FSYYTFWLTASTSVGNGNKSSDIIEVYTDQDIPEGFVGNLTYE---SISSTAINVSWVPP 1077
Query: 1173 SNQSGPIEKY---ILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGC- 1228
+ +G + Y IL P P V+YE S NL + Y + T G
Sbjct: 1078 AQPNGLVFYYVSLILQQTPRHVRPPLVTYE---RSIYFDNLEKYTDYILKITPSTEKGFS 1134
Query: 1229 -LHSLPITVTTAQAPPQRLSP--PKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRS 1285
++ + + T + P+ SP + +SST + + W PP + NG II Y+L ++
Sbjct: 1135 DTYTAQLYIKTEEDVPET-SPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDLTLQ---- 1189
Query: 1286 TKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMA 1345
G +SF+ S N L+ L P+T Y F A
Sbjct: 1190 ---------------GPNENYSFITSDNYIILEE---------LSPFTLYSFFAAARTRK 1225
Query: 1346 GSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQ 1405
G S+ + T ES P + PP L + + + W K + + G +V + E
Sbjct: 1226 GLGPSSILFFYTDESVP--LAPPQNLTLINCTSDFVWLKWSPSPLPGGIVKVYSFKIHEH 1283
Query: 1406 SPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQ--TL 1463
S AK + GL+P Y ++ VG S + T
Sbjct: 1284 ETDTIYYKNISGFKTEAK-------LVGLEPVSTYSIRVSAFTKVGNGNQFSNVVKFTTQ 1336
Query: 1464 AAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLE-RRESSLPALMTTMMKGIRF 1522
+ P ++ + ++ +KW PP++ NG Y + R S+ + M I+
Sbjct: 1337 ESVPDVVQNMQCMATSWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTFIKL 1396
Query: 1523 IGN 1525
+ N
Sbjct: 1397 LAN 1399
Score = 71.2 bits (173), Expect = 2e-11
Identities = 98/414 (23%), Positives = 164/414 (39%), Gaps = 57/414 (13%)
Query: 1096 IYTTEDQYPYSIQY----FLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGN 1151
+ TT +QY I ++ L+P+T++ + + G ++ +T+ VP
Sbjct: 513 VVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSI 572
Query: 1152 LTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLV 1211
++Y I S S+ L W +G I Y + L + + S I L
Sbjct: 573 KIINY-KNISSSSILLYWDPPEYPNGKITHYTIYAMELDTNR-AFQITTIDNSFLITGLK 630
Query: 1212 PFAKYDFSVQACTSGG---CLHSLPITVTTAQAPPQRLSPPKMQKISST--ELHVEWSPP 1266
+ KY V A T G I V T++ P+ SP ++ I T E+ ++WSPP
Sbjct: 631 KYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPES-SPQDVEVIDVTADEIRLKWSPP 689
Query: 1267 AELNGIIIRYELYMRRLRST-KETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTT 1325
+ NGIII YE+ + + + + TS + ++ L PH+
Sbjct: 690 EKPNGIIIAYEVLYKNIDTLYMKNTSTTDIILRN---LRPHTLYN--------------- 731
Query: 1326 ITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKP 1385
+ YT++ N S+ S SE +SAP + ++ SS + +S+ P
Sbjct: 732 -ISVRSYTRFGHG----NQVSSLLSVRTSETVPDSAPENITYKNI---SSGEIELSFLPP 783
Query: 1386 ADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTIT 1445
+ G + Y I + ++ T + L+ ++ LK Y Y ++
Sbjct: 784 SS--PNGIIQKYTIYLKRSNGNEE----------RTINTTSLTQNIKVLKKYTQYIIEVS 831
Query: 1446 LCNSVG-CVTSASGAGQTLAAAPAQLRPP---LVKGINSTTIHLKWFPPEELNG 1495
G V SA + T AP PP VK ++ T+ L W PP E NG
Sbjct: 832 ASTLKGEGVRSAPISILTEEDAPDS--PPQDFSVKQLSGVTVKLSWQPPLEPNG 883
Score = 68.9 bits (167), Expect = 1e-10
Identities = 105/455 (23%), Positives = 172/455 (37%), Gaps = 58/455 (12%)
Query: 1066 SSSAINLSWSPPDSPNAHWLTYSLL---RDGFE---IYTTEDQYPYSIQYFLDTDLLPYT 1119
SS I LS+ PP SPN Y++ +G E I TT + L YT
Sbjct: 772 SSGEIELSFLPPSSPNGIIQKYTIYLKRSNGNEERTINTTSLTQNIKV-------LKKYT 824
Query: 1120 KYSYYIETTNVHGS-TRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGP 1178
+Y + + + G RS ++ T+ P+ + + +V L+W +G
Sbjct: 825 QYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQPPLEPNGI 884
Query: 1179 IEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACT--SGGCLHSLPITV 1236
I Y + + + ETS + +L +Y V A T G S I+
Sbjct: 885 ILYYTVY---VWNRSSLKTINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNIISF 941
Query: 1237 TTAQAPPQRLSPPK---MQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEE 1293
T + P PPK +SS+ + + W+PP++ NGII Y +Y R T
Sbjct: 942 QTPEGAPS--DPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSGT------- 992
Query: 1294 SRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMA--GSVSSA 1351
+F N T I L ++ Y F + A G+ SS
Sbjct: 993 ----------FMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSD 1042
Query: 1352 WVSERTGESAPVFMIPPSVF-PLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQS 1410
+ T + P + + +SS ++N+SW PA +V Y ++++ +Q+P+
Sbjct: 1043 IIEVYTDQDIPEGFVGNLTYESISSTAINVSWVPPAQ---PNGLVFYYVSLILQQTPRHV 1099
Query: 1411 IPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQL 1470
P + E S + L+ Y Y IT G + +
Sbjct: 1100 RP--------PLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPE 1151
Query: 1471 RPPLV---KGINSTTIHLKWFPPEELNGPSPIYQL 1502
P++ K ++ST++ L W PP + NG Y L
Sbjct: 1152 TSPIINTFKNLSSTSVLLSWDPPVKPNGAIISYDL 1186
Score = 67.8 bits (164), Expect = 3e-10
Identities = 120/470 (25%), Positives = 192/470 (40%), Gaps = 80/470 (17%)
Query: 1066 SSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYT--TEDQYPYSIQYFLD----TDLLPYT 1119
+S + L WSP P YS F+I+ T+ Y +I F L P +
Sbjct: 1255 TSDFVWLKWSPSPLPGGIVKVYS-----FKIHEHETDTIYYKNISGFKTEAKLVGLEPVS 1309
Query: 1120 KYSYYIET-TNV-HGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSG 1177
YS + T V +G+ S V + T+ VP+ + + SV + W +G
Sbjct: 1310 TYSIRVSAFTKVGNGNQFSNVVKFTTQESVPDVVQNMQ-CMATSWQSVLVKWDPPKKANG 1368
Query: 1178 PIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGG------C-LH 1230
I +Y+++ + VS + H T L+ Y F V+A TS G C +
Sbjct: 1369 IITQYMVT---VERNSTKVSPQDH--MYTFIKLLANTSYVFKVRASTSAGEGDESTCHVS 1423
Query: 1231 SLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMR-RLRSTKET 1289
+LP TV + P ++ +Q S+T + W P + G Y++ + R + KE
Sbjct: 1424 TLPETVPSV---PTNIAFSDVQSTSAT---LTWIRPDTILGYFQNYKITTQLRAQKCKEW 1477
Query: 1290 TSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SV 1348
SEE +Q +L E T+ GL+ + Y F+V A AG
Sbjct: 1478 ESEECVEYQKIQYLYEAHLTEE-------------TVYGLKKFRWYRFQVAASTNAGYGN 1524
Query: 1349 SSAWVSERTGESAPVFMIPPS---VFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQ 1405
+S W+S +T P PP V S +S++ISW +PA V G Y I++ S
Sbjct: 1525 ASNWISTKTLPGPPDG--PPENVHVVATSPFSISISWSEPA--VITGPTC-YLIDVKSVD 1579
Query: 1406 SPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIY-EFTITLCNSVGCVTSASGAGQ--- 1461
+ + +I KS E + T+E +K I+ +++ + G +++A G+
Sbjct: 1580 NDEFNISFI--------KSNEENKTIE-IKDLEIFTRYSVVITAFTGNISAAYVEGKSSA 1630
Query: 1462 -----TLAAAPAQLRPPLVKGINS-----TTIHLKWFPPEELNGPSPIYQ 1501
TL +AP PP T L + PP + NG +YQ
Sbjct: 1631 EMIVTTLESAPKD--PPNNMTFQKIPDEVTKFQLTFLPPSQPNGNIQVYQ 1678
Score = 66.2 bits (160), Expect = 8e-10
Identities = 96/427 (22%), Positives = 165/427 (38%), Gaps = 67/427 (15%)
Query: 1113 TDLLPYTKYSYYIET--TNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWT 1170
++++P T+Y I + T + T TKPG P +GS + L+W
Sbjct: 22 SNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPP----VFLAGERVGSAGILLSWN 77
Query: 1171 TLSNQSGPIEKYILS----CAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSG 1226
T N +G I YI+ C + V + + NL P Y+ V A S
Sbjct: 78 TPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGTTYEIKVAAENSA 137
Query: 1227 GC-LHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRS 1285
G + S P TA++ P ++ ++ +++ + + W P + NG I +++ ++ RS
Sbjct: 138 GIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGKITSFKISVKHARS 197
Query: 1286 ---TKETT--------------SEESRVFQSS--------GWLSPHS--------FVESA 1312
K+ + +E S F S G ++P S ++
Sbjct: 198 GIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPSRTTHSSSTLTQNE 257
Query: 1313 NENALKPPQTMTTITGLEPYTKYEFRV-LAVNMAGSVSSAWVSERTGESAPVFMIPPS-- 1369
+ K P + +T L PYT Y F V A AG + S V RT ES P PP
Sbjct: 258 ISSVWKEPISFV-VTHLRPYTTYLFEVSAATTEAGYIDSTIV--RTPESVPEG--PPQNC 312
Query: 1370 -VFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELS 1428
++ S +I W+ P + GK Y + + S + +++L
Sbjct: 313 VTGNITGKSFSILWDPP--TIVTGK-FSYRVELYGP-----------SGRILDNSTKDLK 358
Query: 1429 YTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWF 1488
+ L P+ +Y+ I S G ++ + T P + + + ST + + W
Sbjct: 359 FAFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWK 418
Query: 1489 PPEELNG 1495
P + NG
Sbjct: 419 KPRQPNG 425
Score = 65.9 bits (159), Expect = 1e-09
Identities = 74/317 (23%), Positives = 123/317 (38%), Gaps = 53/317 (16%)
Query: 1202 ETSATIWNLVPFAKYDFSVQACTSGGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHV 1261
+ S I LVPF ++ SV A T G ++V T Q P + + ISS+ + +
Sbjct: 528 QLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILL 587
Query: 1262 EWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQ 1321
W PP NG I Y +Y L + +R FQ + +SF+
Sbjct: 588 YWDPPEYPNGKITHYTIYAMEL--------DTNRAFQIT--TIDNSFL------------ 625
Query: 1322 TMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSE---RTGESAPVFMIPP-SVFPLSSYS 1377
ITGL+ YTKY+ RV A G S + ++ RT E P V +++
Sbjct: 626 ----ITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEVIDVTADE 681
Query: 1378 LNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPY 1437
+ + W P G ++ Y++ + + L+ + + L+P+
Sbjct: 682 IRLKWSPP--EKPNGIIIAYEVLYKNIDT------------LYMKNTSTTDIILRNLRPH 727
Query: 1438 RIYEFTITLC------NSVGCVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPE 1491
+Y ++ N V + S + +AP + K I+S I L + PP
Sbjct: 728 TLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENI---TYKNISSGEIELSFLPPS 784
Query: 1492 ELNGPSPIYQLERRESS 1508
NG Y + + S+
Sbjct: 785 SPNGIIQKYTIYLKRSN 801
Score = 64.7 bits (156), Expect = 2e-09
Identities = 95/419 (22%), Positives = 159/419 (37%), Gaps = 74/419 (17%)
Query: 1066 SSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYI 1125
S ++ + W PP N Y + + + + Y+ LL T Y + +
Sbjct: 1352 SWQSVLVKWDPPKKANGIITQYMVTVERNSTKVSPQDHMYTF-----IKLLANTSYVFKV 1406
Query: 1126 ETTNVHG----STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEK 1181
+ G ST V+ +T P VP N+ S + S S TLTW G +
Sbjct: 1407 RASTSAGEGDESTCHVSTLPETVPSVPT-NIAFS---DVQSTSATLTWIRPDTILGYFQN 1462
Query: 1182 YILSCAPLAG------GQPCVSY-------EGHETSATIWNLVPFAKYDFSVQACTSGGC 1228
Y ++ A + CV Y E H T T++ L F Y F V A T+ G
Sbjct: 1463 YKITTQLRAQKCKEWESEECVEYQKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGY 1522
Query: 1229 LH-SLPITVTTAQAPPQRLSPPKMQKISST---ELHVEWSPPAELNGIIIRYELYMRRLR 1284
+ S I+ T PP PP+ + +T + + WS PA + G L
Sbjct: 1523 GNASNWISTKTLPGPPD--GPPENVHVVATSPFSISISWSEPAVITGPTC-------YLI 1573
Query: 1285 STKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNM 1344
K ++E + SF++S EN I LE +T+Y V+
Sbjct: 1574 DVKSVDNDEFNI----------SFIKSNEEN------KTIEIKDLEIFTRYS--VVITAF 1615
Query: 1345 AGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTR------------G 1392
G++S+A+V G+S+ ++ N++++K D VT+ G
Sbjct: 1616 TGNISAAYVE---GKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQLTFLPPSQPNG 1672
Query: 1393 KVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVG 1451
+ Y + E P ++ + ++ + ++ +EGLK Y ++ NS G
Sbjct: 1673 NIQVYQALVYREDDP-TAVQIHNLSIIQKTNTFVIA-MLEGLKGGHTYNISVYAVNSAG 1729
Score = 59.3 bits (142), Expect = 1e-07
Identities = 94/450 (20%), Positives = 158/450 (35%), Gaps = 73/450 (16%)
Query: 1110 FLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTW 1169
F+ T L PYT Y + + + +T VPEG I S ++ W
Sbjct: 268 FVVTHLRPYTTYLFEVSAATTEAGYIDSTIV-RTPESVPEGPPQNCVTGNITGKSFSILW 326
Query: 1170 TTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGCL 1229
+ +G + P + + NL PF YD + A TS G
Sbjct: 327 DPPTIVTGKFSYRVELYGPSGR---ILDNSTKDLKFAFTNLTPFTMYDVYIAAETSAGTG 383
Query: 1230 HSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYE-----------L 1278
I+V T P + ++ ++ ST++ + W P + NGII +Y L
Sbjct: 384 PKSNISVFTPPDVPGAVFDLQLAEVESTQVRITWKKPRQPNGIINQYRVKVLVPETGIIL 443
Query: 1279 YMRRLRSTKETTSE-----------------ESRVFQSSGWLSPHSFVESANENALKP-- 1319
L E ++ E SS S +F+ +++ + P
Sbjct: 444 ENTLLTGNNEYINDPMAPEIVNIVEPMVGLYEGSAEMSSDLHSLATFIYNSHPDKNFPAR 503
Query: 1320 ----PQTMTTITGLEPY-------------------TKYEFRVLAVNMAGSVSSAWVSER 1356
QT +T Y T++ V A + G +S R
Sbjct: 504 NRAEDQTSPVVTTRNQYITDIAAEQLSYVIRRLVPFTEHMISVSAFTIMGEGPPTVLSVR 563
Query: 1357 TGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFS 1416
T + P + + +SS S+ + W+ P GK+ Y I + + + AF
Sbjct: 564 TRQQVPSSIKIINYKNISSSSILLYWDPP--EYPNGKITHYTIYAMELDTNR-----AFQ 616
Query: 1417 QLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVG--CVTSASGAGQTLAAAPAQLRPPL 1474
+ + S+ + GLK Y Y+ + VG ++ + + + P
Sbjct: 617 -----ITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQD 671
Query: 1475 VKGINSTT--IHLKWFPPEELNGPSPIYQL 1502
V+ I+ T I LKW PPE+ NG Y++
Sbjct: 672 VEVIDVTADEIRLKWSPPEKPNGIIIAYEV 701
Score = 54.7 bits (130), Expect = 2e-06
Identities = 52/211 (24%), Positives = 90/211 (42%), Gaps = 35/211 (16%)
Query: 1202 ETSATIWNLVPFAKYDFSVQACTSGGCLHSLPIT--VTTAQAPPQRLSPPKM---QKISS 1256
ET + N+VP +YD ++ + ++ ++ P+T VTT P PP +++ S
Sbjct: 16 ETQVDVSNVVPGTRYDITISSIST---TYTSPVTRIVTTNVTKP---GPPVFLAGERVGS 69
Query: 1257 TELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENA 1316
+ + W+ P NG II Y + + + +T + R
Sbjct: 70 AGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRS-------------------- 109
Query: 1317 LKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERTGESAPVFMIPPSVFPLSS 1375
KP +T L P T YE +V A N AG V S +T ESAP ++ +V ++
Sbjct: 110 -KPDSLEVLLTNLNPGTTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNA 168
Query: 1376 YSLNISWEKPADNVTRGKVVGYDINMLSEQS 1406
++ + W P GK+ + I++ +S
Sbjct: 169 SAVKLIWYLPRQ--PNGKITSFKISVKHARS 197
Score = 46.6 bits (109), Expect = 6e-04
Identities = 40/178 (22%), Positives = 77/178 (43%), Gaps = 13/178 (7%)
Query: 1321 QTMTTITGLEPYTKYEFRVLAVNMA--GSVSSAWVSERTGESAPVFMIPPSVFPLSSYSL 1378
+T ++ + P T+Y+ + +++ V+ + T PVF+ V S +
Sbjct: 16 ETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGERV---GSAGI 72
Query: 1379 NISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYR 1438
+SW P + G+++ Y + Q++ ++Q+ +K L + L P
Sbjct: 73 LLSWNTPPN--PNGRIISYIVKYKEVCPWMQTV---YTQV--RSKPDSLEVLLTNLNPGT 125
Query: 1439 IYEFTITLCNSVGC-VTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNG 1495
YE + NS G V S QT +AP ++ V+ N++ + L W+ P + NG
Sbjct: 126 TYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNG 183
Score = 38.9 bits (89), Expect = 0.14
Identities = 59/281 (20%), Positives = 105/281 (37%), Gaps = 28/281 (9%)
Query: 4687 VLIYNGSSTSFID-SELLPFTEYEYQVWAVNSAGKAPSSW--TWCRTGPAPPEGLRAPTF 4743
+L++ G+S + +D S ++P T Y+ + ++++ +P + T T P PP L
Sbjct: 8 LLLFIGTSETQVDVSNVVPGTRYDITISSISTTYTSPVTRIVTTNVTKPGPPVFLAGER- 66
Query: 4744 HVISSTQAVVNISAPGKPNG-IVSLYRLFSSSAHGAETVLSEGMATQQTLH----GLQAF 4798
+ S +++ + P PNG I+S + +TV ++ + +L L
Sbjct: 67 --VGSAGILLSWNTPPNPNGRIISYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPG 124
Query: 4799 TNYSIGVEACTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGV 4858
T Y I V A +T + P + + + + W P PNG
Sbjct: 125 TTYEIKVAAENSAGIGVFSDPFLFQTAESAPGKVVNLTVEAYNASAVKLIWYLPRQPNGK 184
Query: 4859 IHSYELQ--------------FHVACPPDSALP-CTPSQIETKYTGLGQKASLGGLQP-- 4901
I S+++ V LP C + ++ +LG + P
Sbjct: 185 ITSFKISVKHARSGIVVKDVSIRVEDILTGKLPECNENSESFLWSTASPSPTLGRVTPPS 244
Query: 4902 YTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRAPFSVDS 4942
TT+ + NE+ S E ISF P F V +
Sbjct: 245 RTTHSSSTLTQNEISSVWKEPISFVVTHLRPYTTYLFEVSA 285
>gi|143770880 laminin, beta 4 [Homo sapiens]
Length = 1761
Score = 251 bits (642), Expect = 1e-65
Identities = 137/439 (31%), Positives = 221/439 (50%), Gaps = 46/439 (10%)
Query: 369 VTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNCG-AFGMKNN 427
V+I +DLE ++ ++I+ F + +P + ++R + +W+ ++YFA++C +F +
Sbjct: 114 VSIRLDLE-ALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAKDCATSFPNITS 172
Query: 428 GDLEKPDSVNC-LQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIR 486
G + + C + S+ P + G V +L P Y+ P +Q+ V T +R
Sbjct: 173 GQAQGVGDIVCDSKYSDIEPSTGGEVVLKVLDPSFEIENPYS-----PYIQDLVTLTNLR 227
Query: 487 FHFHGQYYTTETAVNLRHR------YYAVDEITISGRCQCHGHADNC--------DTTSQ 532
+F + + + R YYA+ E+ + G C C+GHA C D S
Sbjct: 228 INFTKLHTLGDALLGRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQKMRGDVFSP 287
Query: 533 PY----RCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNI 588
P +C+C T+G +C+RC + D P+R + C+ C CNSHS CH+++
Sbjct: 288 PGMVHGQCVCQHN--TDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSRCHFDM 345
Query: 589 SVDPFPFEHFRGGG---GVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDT 645
+ + GG GVC+DC+HNT G++C+ C+ F+R S C PC+CD
Sbjct: 346 TT------YLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDP 399
Query: 646 VGTRNGSILCD-------QIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNT 698
GT +G I + GQC CK +V G +C+QC+ Y L DP GC PC+CN
Sbjct: 400 DGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNP 459
Query: 699 SGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKF 758
G++ +TC ++GQC C + V G C+ C G+ L + GC PC C++ G+ +
Sbjct: 460 LGSLP-FLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLH-GCSPCDCDIGGAYSNV 517
Query: 759 CNPHSGQCECKKEAKGLQC 777
C+P +GQCEC+ G C
Sbjct: 518 CSPKNGQCECRPHVTGRSC 536
Score = 248 bits (634), Expect = 9e-65
Identities = 135/415 (32%), Positives = 196/415 (47%), Gaps = 42/415 (10%)
Query: 641 CDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSG 700
C C G+ S C ++GGQC CK V GR C++C G Y+L GC PC+C+ G
Sbjct: 769 CKCHPQGSVGSS--CSRLGGQCQCKPLVVGRCCDRCSTGSYDLGH---HGCHPCHCHPQG 823
Query: 701 TVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCN 760
+ D C Q +GQC C V G RCD C G+ F C PC CN + C+
Sbjct: 824 SKD--TVCDQVTGQCPCHGEVSGRRCDRCLAGY-----FGFPSCHPCPCNRFAEL---CD 873
Query: 761 PHSGQC-ECKKEAKGLQCDTCRENFYGLDVTN--CKACDCDTAGSLPGTVCNAKTGQ--- 814
P +G C C G C+ C + +YG + C+ C C S ++
Sbjct: 874 PETGSCFNCGGFTTGRNCERCIDGYYGNPSSGQPCRPCLCPDDPSSNQYFAHSCYQNLWS 933
Query: 815 ----CICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQC-P 869
C C G QC +C G + + + C PC C+ + C++ TG+C
Sbjct: 934 SDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLR 993
Query: 870 CKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLP--------GTICDPISGQCL 921
C G C C+P Y ++ Q C+ C C + G P +CDP++G C
Sbjct: 994 CLHNTQGANCQLCKPGHYGSALN--QTCRRCSCHASGVSPMECPPGGGACLCDPVTGACP 1051
Query: 922 CVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQ 980
C+PN G C++C G++ + PG GC C C + + C+ LTGQC C+ G+
Sbjct: 1052 CLPNVTGLACDRCADGYWNLVPGR--GCQSCDCDPRTSQSSHCDQLTGQCPCK-LGYGGK 1108
Query: 981 RCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDAC 1035
RC +C+++Y+G P GRC PC+C+ +G C TG C C++ V+G +CD C
Sbjct: 1109 RCSECQENYYGDPP--GRCIPCDCNRAGTQKPICDPDTGMCRCREGVSGQRCDRC 1161
Score = 186 bits (472), Expect = 5e-46
Identities = 128/446 (28%), Positives = 179/446 (40%), Gaps = 76/446 (17%)
Query: 518 CQCHGHADNCDTTSQ-PYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQ 576
C+CH + S+ +C C + G CDRC D C PC
Sbjct: 769 CKCHPQGSVGSSCSRLGGQCQC--KPLVVGRCCDRCSTGSYDLGHH--------GCHPCH 818
Query: 577 CNSHSKSCHYNISVDPFPFEHFRGGGGVCDD------CEHNTTGRNCELCKDYFFRQVGA 630
C+ VCD C +GR C+ C +F
Sbjct: 819 CHPQGSK------------------DTVCDQVTGQCPCHGEVSGRRCDRCLAGYF----- 855
Query: 631 DPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC-NCKRHVSGRQCNQCQNGFYNLQELDPD 689
C PC C+ LCD G C NC +GR C +C +G+Y
Sbjct: 856 ---GFPSCHPCPCNRFAE-----LCDPETGSCFNCGGFTTGRNCERCIDGYYG-NPSSGQ 906
Query: 690 GCSPCNC--NTSGTVDGDITCHQNSGQ----CKCKANVIGLRCDHCNFGFKFLRSFNDVG 743
C PC C + S +C+QN C C G +C C+ GF +
Sbjct: 907 PCRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAP 966
Query: 744 CEPCQCNLHGSVN--KFCNPHSGQC-ECKKEAKGLQCDTCRENFYGLDVTN-CKACDCDT 799
C+PC CN + V + C+ +G+C C +G C C+ YG + C+ C C
Sbjct: 967 CQPCACNNNIDVTDPESCSRVTGECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHA 1026
Query: 800 AGSLP--------GTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDK 851
+G P +C+ TG C C PNV G C++C +G + L C C+CD
Sbjct: 1027 SGVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPGRG--CQSCDCDP 1084
Query: 852 TGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGT 911
+ S C++ TGQCPCKLG G RC++C+ + Y D C C+C+ GT
Sbjct: 1085 R--TSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYG---DPPGRCIPCDCNRAGTQK-P 1138
Query: 912 ICDPISGQCLCVPNRQGRRCNQCQPG 937
ICDP +G C C G+RC++C G
Sbjct: 1139 ICDPDTGMCRCREGVSGQRCDRCARG 1164
Score = 162 bits (411), Expect = 6e-39
Identities = 113/363 (31%), Positives = 146/363 (40%), Gaps = 84/363 (23%)
Query: 743 GCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGS 802
G C+C+ GSV C+ GQC+CK G CD C Y L C C C GS
Sbjct: 765 GAVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDLGHHGCHPCHCHPQGS 824
Query: 803 LPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCN 862
TVC+ TGQC C V GR+C++CL G F C PC C++ LC+
Sbjct: 825 -KDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPS-----CHPCPCNRFAE-----LCD 873
Query: 863 KSTGQC-PCKLGVTGLRCNQC-----------EPHRYNLTIDN------FQH-------- 896
TG C C TG C +C +P R L D+ F H
Sbjct: 874 PETGSCFNCGGFTTGRNCERCIDGYYGNPSSGQPCRPCLCPDDPSSNQYFAHSCYQNLWS 933
Query: 897 ---------------CQMCECDSLGT--LPGTICDP-----------------ISGQCL- 921
C C G + G C P ++G+CL
Sbjct: 934 SDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVTDPESCSRVTGECLR 993
Query: 922 CVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNH---------ICNSLTGQCVC 972
C+ N QG C C+PG Y S N T C CSCH +G +C+ +TG C C
Sbjct: 994 CLHNTQGANCQLCKPGHYGSALNQT-CRRCSCHASGVSPMECPPGGGACLCDPVTGACPC 1052
Query: 973 QDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKC 1032
++ G CD+C D Y+ P G CQ C+C + + C +TGQC CK G +C
Sbjct: 1053 L-PNVTGLACDRCADGYWNLVPGRG-CQSCDCDPRTSQSSHCDQLTGQCPCKLGYGGKRC 1110
Query: 1033 DAC 1035
C
Sbjct: 1111 SEC 1113
Score = 160 bits (406), Expect = 2e-38
Identities = 102/343 (29%), Positives = 147/343 (42%), Gaps = 65/343 (18%)
Query: 671 RQCNQCQNGFYNLQELDPDGCSPCN-----CNTSGTVDGDITCHQNS--GQCKCKANVIG 723
RQ + +Y L E+ G CN C + GD+ GQC C+ N G
Sbjct: 244 RQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQKMRGDVFSPPGMVHGQCVCQHNTDG 303
Query: 724 LRCDHCNFGFKFL-----RSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCD 778
C+ C F+ D C C CN HS +C
Sbjct: 304 PNCERCKDFFQDAPWRPAADLQDNACRSCS----------CNSHSSRCH----------- 342
Query: 779 TCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQ 838
D+T A +G L G VC C+ N EG+ C++C FY
Sbjct: 343 --------FDMTTYLA-----SGGLSGGVCED------CQHNTEGQHCDRC-RPLFYRDP 382
Query: 839 ----NNSFLCLPCNCDKTGTINGSLLCNKS-------TGQCPCKLGVTGLRCNQCEPHRY 887
++ + C+PC CD GTI+G + + S GQC CK V G +C+QC+P+ Y
Sbjct: 383 LKTISDPYACIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHY 442
Query: 888 NLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATG 947
L+ + CQ C+C+ LG+LP CD +GQCLC+ G C +C G++ + G
Sbjct: 443 GLSATDPLGCQPCDCNPLGSLPFLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHG 502
Query: 948 CLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYF 990
C PC C GA +++C+ GQC C+ + G+ C + YF
Sbjct: 503 CSPCDCDIGGAYSNVCSPKNGQCECR-PHVTGRSCSEPAPGYF 544
Score = 160 bits (405), Expect = 3e-38
Identities = 110/381 (28%), Positives = 148/381 (38%), Gaps = 97/381 (25%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577
C CH DT C G CDRCL Y P +C PC C
Sbjct: 817 CHCHPQGSK-DTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFP----------SCHPCPC 865
Query: 578 NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDV 637
N ++ C DP G C +C TTGRNCE C D ++ +PS+
Sbjct: 866 NRFAELC------DPET--------GSCFNCGGFTTGRNCERCIDGYY----GNPSSGQP 907
Query: 638 CKPCDC--DTVGTRNGSILCDQIGGQ----CNCKRHVSGRQCNQCQNGFY---------- 681
C+PC C D + + C Q CNC + +G QC +C GFY
Sbjct: 908 CRPCLCPDDPSSNQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPC 967
Query: 682 -------NLQELDPDGCSP-----------------------------------CNCNTS 699
N+ DP+ CS C+C+ S
Sbjct: 968 QPCACNNNIDVTDPESCSRVTGECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHAS 1027
Query: 700 GTVD-------GDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLH 752
G G C +G C C NV GL CD C G+ L GC+ C C+
Sbjct: 1028 GVSPMECPPGGGACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPGR--GCQSCDCDPR 1085
Query: 753 GSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKT 812
S + C+ +GQC CK G +C C+EN+YG C CDC+ AG+ +C+ T
Sbjct: 1086 TSQSSHCDQLTGQCPCKLGYGGKRCSECQENYYGDPPGRCIPCDCNRAGT-QKPICDPDT 1144
Query: 813 GQCICKPNVEGRQCNKCLEGN 833
G C C+ V G++C++C G+
Sbjct: 1145 GMCRCREGVSGQRCDRCARGH 1165
Score = 147 bits (370), Expect = 4e-34
Identities = 98/313 (31%), Positives = 142/313 (45%), Gaps = 70/313 (22%)
Query: 758 FCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCIC 817
FCN H+ +C ++ +G DV S PG V GQC+C
Sbjct: 266 FCNGHASECRPMQKMRG-------------DVF-----------SPPGMV----HGQCVC 297
Query: 818 KPNVEGRQCNKCLEGNFYLR---------QNNSFLCLPCNCDK----------TGTINGS 858
+ N +G C +C + F+ Q+N+ C C+C+ T +G
Sbjct: 298 QHNTDGPNCERCKD--FFQDAPWRPAADLQDNA--CRSCSCNSHSSRCHFDMTTYLASGG 353
Query: 859 LLCNKSTGQCP-CKLGVTGLRCNQCEPHRYN---LTIDNFQHCQMCECDSLGTLPGTIC- 913
L S G C C+ G C++C P Y TI + C CECD GT+ G IC
Sbjct: 354 L----SGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPDGTISGGICV 409
Query: 914 ---DP----ISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAVNHI-CN 964
DP ++GQCLC N +G +C+QC+P Y +S + GC PC C+ G++ + C+
Sbjct: 410 SHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPLGSLPFLTCD 469
Query: 965 SLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCK 1024
TGQC+C + + G C++C Y+G C PC+C + GA + C GQC C+
Sbjct: 470 VDTGQCLCL-SYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCSPKNGQCECR 528
Query: 1025 QFVTGSKCDACVP 1037
VTG C P
Sbjct: 529 PHVTGRSCSEPAP 541
Score = 108 bits (269), Expect = 2e-22
Identities = 54/138 (39%), Positives = 74/138 (53%), Gaps = 12/138 (8%)
Query: 900 CECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAV 959
C+C G++ G+ C + GQC C P GR C++C G Y + GC PC CH G+
Sbjct: 769 CKCHPQGSV-GSSCSRLGGQCQCKPLVVGRCCDRCSTGSYDLGHH--GCHPCHCHPQGSK 825
Query: 960 NHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTG 1019
+ +C+ +TGQC C ++G+RCD+C YFGF C PC C+ E C TG
Sbjct: 826 DTVCDQVTGQCPCH-GEVSGRRCDRCLAGYFGFPS----CHPCPCN---RFAELCDPETG 877
Query: 1020 QCF-CKQFVTGSKCDACV 1036
CF C F TG C+ C+
Sbjct: 878 SCFNCGGFTTGRNCERCI 895
Score = 78.6 bits (192), Expect = 2e-13
Identities = 52/181 (28%), Positives = 77/181 (42%), Gaps = 32/181 (17%)
Query: 901 ECDSLGTLPGTICDP---ISGQCLCVPNRQGRRCNQCQPGFYISPGNATG------CLPC 951
EC + + G + P + GQC+C N G C +C+ F +P C C
Sbjct: 273 ECRPMQKMRGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSC 332
Query: 952 SCHTTGAVNHI-------CNSLTGQCVCQDA--SIAGQRCDQCKDHYFGFDPQT----GR 998
SC++ + H L+G VC+D + GQ CD+C+ ++ +T
Sbjct: 333 SCNSHSSRCHFDMTTYLASGGLSGG-VCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYA 391
Query: 999 CQPCNCHLSGALN---------ETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLG 1049
C PC C G ++ V GQC CK+ V G+KCD C P+ L + LG
Sbjct: 392 CIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLG 451
Query: 1050 C 1050
C
Sbjct: 452 C 452
Score = 78.6 bits (192), Expect = 2e-13
Identities = 35/90 (38%), Positives = 49/90 (54%), Gaps = 3/90 (3%)
Query: 947 GCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHL 1006
G + C CH G+V C+ L GQC C+ + G+ CD+C +D C PC+CH
Sbjct: 765 GAVACKCHPQGSVGSSCSRLGGQCQCKPL-VVGRCCDRCSTG--SYDLGHHGCHPCHCHP 821
Query: 1007 SGALNETCHLVTGQCFCKQFVTGSKCDACV 1036
G+ + C VTGQC C V+G +CD C+
Sbjct: 822 QGSKDTVCDQVTGQCPCHGEVSGRRCDRCL 851
Score = 72.0 bits (175), Expect = 1e-11
Identities = 60/222 (27%), Positives = 82/222 (36%), Gaps = 67/222 (30%)
Query: 518 CQCHGHADNCDTTSQPYRC-------LCSQ-ESFTEGLHCDRCLPLYNDKPFRQGDQVYA 569
C C+ H+ C Y +C + TEG HCDRC PL+ P + YA
Sbjct: 332 CSCNSHSSRCHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYA 391
Query: 570 FNCKPCQCN-----------SHS-------------------------KSCHYNISV-DP 592
C PC+C+ SHS K HY +S DP
Sbjct: 392 --CIPCECDPDGTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDP 449
Query: 593 F-------------PFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCK 639
PF G C C TG +CE C ++ + + C
Sbjct: 450 LGCQPCDCNPLGSLPFLTCDVDTGQCL-CLSYVTGAHCEECTVGYWGL----GNHLHGCS 504
Query: 640 PCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFY 681
PCDCD G + +C GQC C+ HV+GR C++ G++
Sbjct: 505 PCDCDIGGAYSN--VCSPKNGQCECRPHVTGRSCSEPAPGYF 544
>gi|145309326 laminin, gamma 1 precursor [Homo sapiens]
Length = 1609
Score = 245 bits (626), Expect = 7e-64
Identities = 143/428 (33%), Positives = 227/428 (53%), Gaps = 37/428 (8%)
Query: 340 HPLSFVND--NDVGTSWVSNVFTNITQLNQGVTISVDLENGQ-YQVFYIIIQFFSPQPTE 396
H +F+ D N T+W + T + + +I++ L G+ + + Y+ ++F + +P
Sbjct: 101 HGAAFLTDYNNQADTTWWQSQ-TMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPES 159
Query: 397 IRIQRKKENSLDWEDWQYFARNC-GAFGMKNNGDL----EKPDSVNCLQLSNFTPYSRGN 451
I ++ W +QY++ +C + N G + ++ ++ + S+ +P + GN
Sbjct: 160 FAIYKRTREDGPWIPYQYYSGSCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGN 219
Query: 452 VTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHFHGQYYTTETAVN----LRHRYY 507
V FS L RP NF N+P LQE+V AT IR + + N L+ YY
Sbjct: 220 VAFSTLEG----RPSAYNFDNSPVLQEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYY 275
Query: 508 AVDEITISGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQV 567
A+ + + GRC+C+GHA C ++ + +C+ + T G+ C++CLP +ND+P+R+
Sbjct: 276 AISDFAVGGRCKCNGHASEC-MKNEFDKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAE 334
Query: 568 YAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQ 627
A C PC CN S+ C++ DP + G GG C +C+ NT G +CE C++ FFR
Sbjct: 335 SASECLPCDCNGRSQECYF----DPELYRS-TGHGGHCTNCQDNTDGAHCERCRENFFR- 388
Query: 628 VGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELD 687
+G + + C C C VG+ S CD G+C+CK V G +C++CQ GF++L E
Sbjct: 389 LGNN----EACSSCHCSPVGSL--STQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEA- 440
Query: 688 PDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPC 747
GC PC+C+ SG++D C+ +G+C CK NV G C+ C GF L S N GC PC
Sbjct: 441 --GCRPCSCDPSGSID---ECNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPC 495
Query: 748 QCNLHGSV 755
C H SV
Sbjct: 496 FCFGHSSV 503
Score = 197 bits (500), Expect = 3e-49
Identities = 114/356 (32%), Positives = 172/356 (48%), Gaps = 29/356 (8%)
Query: 715 CKCKANVIGLRCDHCNFGFKFLRSFNDVG----CEPCQCNLHGSVNKFCNPHSGQCECKK 770
C C G C+ C G++ R ++G C C CN H C+P +G C C+
Sbjct: 690 CTCPVGYGGQFCEMCLSGYR--RETPNLGPYSPCVLCACNGHSET---CDPETGVCNCRD 744
Query: 771 EAKGLQCDTCRENFYGLDV----TNCKACDCDTAGSLPGTVCNAKTGQCI-CKPNVEGRQ 825
G C+ C + +YG ++C+ C C GS V K C C G++
Sbjct: 745 NTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP-GGSSCAVVPKTKEVVCTNCPTGTTGKR 803
Query: 826 CNKCLEGNFY--LRQNNSF-LCLPCNCDKTGTINGSLLCNKSTGQC-PCKLGVTGLRCNQ 881
C C +G F L +N LC C C N CN+ TG+C C G C++
Sbjct: 804 CELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDR 863
Query: 882 CEPHRYN--LTIDNFQHCQMCECDSLGTLPG-TICDPISGQCLCVPNRQGRRCNQCQPGF 938
C+ + L + C+ C C+ GT+ + C+P++GQC C+P+ G+ C C PGF
Sbjct: 864 CKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGF 923
Query: 939 YISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGR 998
Y + + GC C CH G+ N C+ TGQC CQ I GQ C++C+ ++FGF P+
Sbjct: 924 Y-NLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPG-ITGQHCERCEVNHFGFGPEG-- 979
Query: 999 CQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTP 1054
C+PC+CH G+L+ C G+C C++ G++CD C ++ + GC + P
Sbjct: 980 CKPCDCHPEGSLSLQCK-DDGRCECREGFVGNRCDQC--EENYFYNRSWPGCQECP 1032
Score = 192 bits (489), Expect = 6e-48
Identities = 108/323 (33%), Positives = 159/323 (49%), Gaps = 26/323 (8%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577
C C+GH++ CD P +C+ T G HC++C +D + + +C+PC C
Sbjct: 724 CACNGHSETCD----PETGVCNCRDNTAGPHCEKC----SDGYYGDSTAGTSSDCQPCPC 775
Query: 578 NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDV 637
S SC +V P E VC +C TTG+ CELC D +F + +
Sbjct: 776 PGGS-SC----AVVPKTKEV------VCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRL 824
Query: 638 CKPCDCDTVGTRNGSILCDQIGGQC-NCKRHVSGRQCNQCQNGFYN--LQELDPDGCSPC 694
C+ C C N C+++ G+C C + +G C++C++GF+ L D C C
Sbjct: 825 CRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKAC 884
Query: 695 NCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGS 754
NCN GT+ +C+ +GQC+C +V G C C+ GF L+S GCE C C+ GS
Sbjct: 885 NCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQ--GCERCDCHALGS 942
Query: 755 VNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQ 814
N C+ +GQCEC+ G C+ C N +G CK CDC GSL ++ G+
Sbjct: 943 TNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSL--SLQCKDDGR 1000
Query: 815 CICKPNVEGRQCNKCLEGNFYLR 837
C C+ G +C++C E FY R
Sbjct: 1001 CECREGFVGNRCDQCEENYFYNR 1023
Score = 184 bits (467), Expect = 2e-45
Identities = 117/359 (32%), Positives = 163/359 (45%), Gaps = 35/359 (9%)
Query: 662 CNCKRHVSGRQCNQCQNGFY----NLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKC 717
C C G+ C C +G+ NL P C C CN TC +G C C
Sbjct: 690 CTCPVGYGGQFCEMCLSGYRRETPNLGPYSP--CVLCACNGHSE-----TCDPETGVCNC 742
Query: 718 KANVIGLRCDHCNFGFKF-LRSFNDVGCEPCQCNLHGSVNKFCNPHSGQC-ECKKEAKGL 775
+ N G C+ C+ G+ + C+PC C S C C G
Sbjct: 743 RDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGK 802
Query: 776 QCDTCRENFYGLD------VTNCKACDCDTAGSLPGTV--CNAKTGQCI-CKPNVEGRQC 826
+C+ C + ++G V C+ C C P V CN TG+C+ C N G C
Sbjct: 803 RCELCDDGYFGDPLGRNGPVRLCRLCQCSDNID-PNAVGNCNRLTGECLKCIYNTAGFYC 861
Query: 827 NKCLEGNFY--LRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEP 884
++C +G F L N + C CNC+ GT+ CN TGQC C VTG C C+P
Sbjct: 862 DRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDP 921
Query: 885 HRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPG-FYISPG 943
YNL + Q C+ C+C +LG+ G CD +GQC C P G+ C +C+ F P
Sbjct: 922 GFYNL--QSGQGCERCDCHALGSTNGQ-CDIRTGQCECQPGITGQHCERCEVNHFGFGP- 977
Query: 944 NATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPC 1002
GC PC CH G+++ C G+C C++ + G RCDQC+++YF ++ CQ C
Sbjct: 978 --EGCKPCDCHPEGSLSLQCKD-DGRCECREGFV-GNRCDQCEENYF-YNRSWPGCQEC 1031
Score = 166 bits (419), Expect = 7e-40
Identities = 105/357 (29%), Positives = 160/357 (44%), Gaps = 30/357 (8%)
Query: 608 CEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRH 667
C G+ CE+C + R+ + C C C+ S CD G CNC+ +
Sbjct: 692 CPVGYGGQFCEMCLSGYRRET-PNLGPYSPCVLCACN-----GHSETCDPETGVCNCRDN 745
Query: 668 VSGRQCNQCQNGFYNLQELDPDG-CSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRC 726
+G C +C +G+Y C PC C G+ + + C G RC
Sbjct: 746 TAGPHCEKCSDGYYGDSTAGTSSDCQPCPC-PGGSSCAVVPKTKEVVCTNCPTGTTGKRC 804
Query: 727 DHCN---FGFKFLRSFNDVGCEPCQC--NLHGSVNKFCNPHSGQC-ECKKEAKGLQCDTC 780
+ C+ FG R+ C CQC N+ + CN +G+C +C G CD C
Sbjct: 805 ELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRC 864
Query: 781 RENFYGLDVT-----NCKACDCDTAGSL-PGTVCNAKTGQCICKPNVEGRQCNKCLEGNF 834
++ F+G + CKAC+C+ G++ + CN TGQC C P+V G+ C C G +
Sbjct: 865 KDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFY 924
Query: 835 YLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNF 894
L+ C C+C G+ NG C+ TGQC C+ G+TG C +CE + + +
Sbjct: 925 NLQSGQG--CERCDCHALGSTNGQ--CDIRTGQCECQPGITGQHCERCEVNHFGFGPEG- 979
Query: 895 QHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPC 951
C+ C+C G+L D G+C C G RC+QC+ ++ + + GC C
Sbjct: 980 --CKPCDCHPEGSLSLQCKD--DGRCECREGFVGNRCDQCEENYFYN-RSWPGCQEC 1031
Score = 126 bits (317), Expect = 5e-28
Identities = 70/215 (32%), Positives = 100/215 (46%), Gaps = 20/215 (9%)
Query: 662 CNCKRHVSGRQCNQCQNGFYN-----LQELDPDGCSPCNCN-TSGTVDGDITCHQNSGQ- 714
CNCK + G C +C F + C PC+CN S D ++++G
Sbjct: 305 CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
Query: 715 ---CKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKE 771
C+ N G C+ C F R N+ C C C+ GS++ C+ + G+C CK
Sbjct: 365 GHCTNCQDNTDGAHCERCRENF--FRLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKPG 421
Query: 772 AKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLE 831
G +CD C+ F+ L C+ C CD +GS+ CN +TG+C+CK NVEG C +C
Sbjct: 422 VMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDE--CNIETGRCVCKDNVEGFNCERCKP 479
Query: 832 GNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTG 866
G F L +N C PC C S +C + G
Sbjct: 480 GFFNLESSNPRGCTPCFC-----FGHSSVCTNAVG 509
Score = 124 bits (311), Expect = 2e-27
Identities = 78/242 (32%), Positives = 107/242 (44%), Gaps = 37/242 (15%)
Query: 680 FYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSF 739
+Y + + G CN + S + + + C CK N G+ C+ C L F
Sbjct: 274 YYAISDFAVGGRCKCNGHASECMKNEF----DKLVCNCKHNTYGVDCEKC------LPFF 323
Query: 740 ND-----------VGCEPCQCNLHGSVNKF------CNPHSGQC-ECKKEAKGLQCDTCR 781
ND C PC CN F H G C C+ G C+ CR
Sbjct: 324 NDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCR 383
Query: 782 ENFYGLDVTN-CKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNN 840
ENF+ L C +C C GSL T C++ G+C CKP V G +C++C G L +
Sbjct: 384 ENFFRLGNNEACSSCHCSPVGSL-STQCDSY-GRCSCKPGVMGDKCDRCQPGFHSLTEAG 441
Query: 841 SFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMC 900
C PC+CD +G+I+ CN TG+C CK V G C +C+P +NL N + C C
Sbjct: 442 ---CRPCSCDPSGSIDE---CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPC 495
Query: 901 EC 902
C
Sbjct: 496 FC 497
Score = 119 bits (297), Expect = 1e-25
Identities = 87/281 (30%), Positives = 118/281 (41%), Gaps = 40/281 (14%)
Query: 796 DCDTAGSLPGTVCNAK-TGQCICKPNVEGRQCNKCLEGNFYLRQNNSF----LCLPCNCD 850
D A + PG A C C G+ C CL G Y R+ + C+ C C+
Sbjct: 670 DVTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSG--YRRETPNLGPYSPCVLCACN 727
Query: 851 KTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRY-NLTIDNFQHCQMCEC---DSLG 906
S C+ TG C C+ G C +C Y + T CQ C C S
Sbjct: 728 -----GHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCA 782
Query: 907 TLPGT---ICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATG----CLPCSCHTTGAV 959
+P T +C C G+RC C G++ P G C C C
Sbjct: 783 VVPKTKEVVCTN------CPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDP 836
Query: 960 NHI--CNSLTGQCVCQDASIAGQRCDQCKDHYFGFDP----QTGRCQPCNCHLSGALNE- 1012
N + CN LTG+C+ + AG CD+CKD +FG +P +C+ CNC+L G + +
Sbjct: 837 NAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFG-NPLAPNPADKCKACNCNLYGTMKQQ 895
Query: 1013 -TCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSK 1052
+C+ VTGQC C VTG C AC P +L GC +
Sbjct: 896 SSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQ--GCER 934
Score = 117 bits (294), Expect = 2e-25
Identities = 72/240 (30%), Positives = 112/240 (46%), Gaps = 42/240 (17%)
Query: 759 CNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNC---------KACDCDTAGSLPGTVCN 809
CN H+ +C K E L C+ C+ N YG+D C + ++A CN
Sbjct: 288 CNGHASEC-MKNEFDKLVCN-CKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN 345
Query: 810 AKTGQCI-----------------CKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKT 852
++ +C C+ N +G C +C E F L N + C C+C
Sbjct: 346 GRSQECYFDPELYRSTGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEA--CSSCHCSPV 403
Query: 853 GTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI 912
G++ S C+ S G+C CK GV G +C++C+P ++LT C+ C CD G++
Sbjct: 404 GSL--STQCD-SYGRCSCKPGVMGDKCDRCQPGFHSLTEAG---CRPCSCDPSGSIDE-- 455
Query: 913 CDPISGQCLCVPNRQGRRCNQCQPGFY-ISPGNATGCLPCSCHTTGAVNHICNSLTGQCV 971
C+ +G+C+C N +G C +C+PGF+ + N GC PC C +V C + G V
Sbjct: 456 CNIETGRCVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSV---CTNAVGYSV 512
Score = 102 bits (254), Expect = 1e-20
Identities = 62/198 (31%), Positives = 95/198 (47%), Gaps = 23/198 (11%)
Query: 868 CPCKLGVTGLRCNQCEPHRYN-----LTIDNFQHCQMCECDSLGTLPGTICDPI------ 916
C CK G+ C +C P + T ++ C C+C+ G DP
Sbjct: 305 CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCN--GRSQECYFDPELYRSTG 362
Query: 917 -SGQCL-CVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQD 974
G C C N G C +C+ F+ GN C C C G+++ C+S G+C C+
Sbjct: 363 HGGHCTNCQDNTDGAHCERCRENFF-RLGNNEACSSCHCSPVGSLSTQCDSY-GRCSCKP 420
Query: 975 ASIAGQRCDQCKDHYFGFDPQT-GRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCD 1033
+ G +CD+C+ GF T C+PC+C SG+++E C++ TG+C CK V G C+
Sbjct: 421 G-VMGDKCDRCQP---GFHSLTEAGCRPCSCDPSGSIDE-CNIETGRCVCKDNVEGFNCE 475
Query: 1034 ACVPSASHLDVNNLLGCS 1051
C P +L+ +N GC+
Sbjct: 476 RCKPGFFNLESSNPRGCT 493
Score = 69.3 bits (168), Expect = 9e-11
Identities = 46/148 (31%), Positives = 62/148 (41%), Gaps = 16/148 (10%)
Query: 920 CLCVPNRQGRRCNQCQPGFYISPG------NATGCLPCSCHTTGAVNHICNSLT------ 967
C C N G C +C P F P +A+ CLPC C+ + L
Sbjct: 305 CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
Query: 968 GQCV-CQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQF 1026
G C CQD + G C++C++++F C C+C G+L+ C G+C CK
Sbjct: 365 GHCTNCQD-NTDGAHCERCRENFFRLGNNEA-CSSCHCSPVGSLSTQCDSY-GRCSCKPG 421
Query: 1027 VTGSKCDACVPSASHLDVNNLLGCSKTP 1054
V G KCD C P L CS P
Sbjct: 422 VMGDKCDRCQPGFHSLTEAGCRPCSCDP 449
Score = 36.6 bits (83), Expect = 0.67
Identities = 21/67 (31%), Positives = 27/67 (40%), Gaps = 9/67 (13%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577
C G D C+ + RC+C EG +C+RC P F + C PC C
Sbjct: 447 CDPSGSIDECNIETG--RCVCKDN--VEGFNCERCKP-----GFFNLESSNPRGCTPCFC 497
Query: 578 NSHSKSC 584
HS C
Sbjct: 498 FGHSSVC 504
>gi|110611156 laminin, gamma 3 precursor [Homo sapiens]
Length = 1575
Score = 231 bits (590), Expect = 1e-59
Identities = 145/433 (33%), Positives = 210/433 (48%), Gaps = 47/433 (10%)
Query: 340 HPLSFVND---NDVGTSWVSNVFTNITQLNQGVTISVDLENGQYQVFYIIIQFFSPQPTE 396
H S++ D D T W S Q V I++ L Y++ Y+ ++F + +P
Sbjct: 86 HNASYLTDFHSQDESTWWQSPSMAFGVQYPTSVNITLRLGKA-YEITYVRLKFHTSRPES 144
Query: 397 IRIQRKKENSLDWEDWQYFARNCGAFGMKNNGDLEKPDSVNCL-----QLSNFTPYSRGN 451
I ++ WE +Q+++ +C + G +P + + S+ +P S GN
Sbjct: 145 FAIYKRSRADGPWEPYQFYSASCQKTYGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGN 204
Query: 452 VTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQI-----RFHFHGQYYTTETAVNLRHRY 506
V FS L RP NF +P LQE+V +T++ R + G + V L+ Y
Sbjct: 205 VAFSTLEG----RPSAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIFKDPKV-LQSYY 259
Query: 507 YAVDEITISGRCQCHGHADNC--DTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQG 564
YAV + ++ GRC+C+GHA C D Q C C T G C+RCLP + D+P+ +G
Sbjct: 260 YAVSDFSVGGRCKCNGHASECGPDVAGQ-LACRCQHN--TTGTDCERCLPFFQDRPWARG 316
Query: 565 DQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFR--GGGGVCDDCEHNTTGRNCELCKD 622
A C PC C+ S+ C F E FR G GG C C +T G +CE C++
Sbjct: 317 TAEAAHECLPCNCSGRSEEC-------TFDRELFRSTGHGGRCHHCRDHTAGPHCERCQE 369
Query: 623 YFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYN 682
F+ DP C+PCDC + G+ + + CD G C CK V+G +C++C GF++
Sbjct: 370 NFYHW---DPRM--PCQPCDCQSAGSLH--LQCDDT-GTCACKPTVTGWKCDRCLPGFHS 421
Query: 683 LQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDV 742
L E GC PC CN +G++D TC SG+C CK NV G CD C G L+ N
Sbjct: 422 LSE---GGCRPCTCNPAGSLD---TCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPA 475
Query: 743 GCEPCQCNLHGSV 755
GC C C H V
Sbjct: 476 GCSSCFCYGHSKV 488
Score = 186 bits (471), Expect = 7e-46
Identities = 110/337 (32%), Positives = 150/337 (44%), Gaps = 37/337 (10%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577
C C+ H CD + C+CS TEG C+RCLP + PF A +C+PC C
Sbjct: 707 CTCNQHG-TCDPNTGI--CVCSHH--TEGPSCERCLPGFYGNPFAG----QADDCQPCPC 757
Query: 578 NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAI-- 635
S S + VC C GR CE+C D FF DP +
Sbjct: 758 PGQSACTTIPESREV-----------VCTHCPPGQRGRRCEVCDDGFF----GDPLGLFG 802
Query: 636 --DVCKPCDCDTVGTRNGSILCDQIGGQC-NCKRHVSGRQCNQCQNGFYN--LQELDPDG 690
C C C N CD + G C C + +G C CQ GFY L D
Sbjct: 803 HPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADK 862
Query: 691 CSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCN 750
C PC+C+ G+V + C +GQC C +V C C GF L+ GC C+C+
Sbjct: 863 CMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDLQPGR--GCRSCKCH 920
Query: 751 LHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNA 810
GS C+P +GQC C+ G CD C+ F+G + C+AC C G+ C+
Sbjct: 921 PLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGA-ASAQCH- 978
Query: 811 KTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPC 847
+ G C+C+P EG +C++C NF+L + + C C
Sbjct: 979 ENGTCVCRPGFEGYKCDRC-HDNFFLTADGTH-CQQC 1013
Score = 182 bits (463), Expect = 6e-45
Identities = 109/338 (32%), Positives = 156/338 (46%), Gaps = 30/338 (8%)
Query: 715 CKCKANVIGLRCDHCNFGFKFLRSFNDVG----CEPCQCNLHGSVNKFCNPHSGQCECKK 770
C C G C+ C G+K R G C PC CN HG+ C+P++G C C
Sbjct: 673 CSCPTGYTGQFCESCAPGYK--REMPQGGPYASCVPCTCNQHGT----CDPNTGICVCSH 726
Query: 771 EAKGLQCDTCRENFYGL----DVTNCKACDCDTAGSLPGTVCNAKTGQCI-CKPNVEGRQ 825
+G C+ C FYG +C+ C C + T+ ++ C C P GR+
Sbjct: 727 HTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACT-TIPESREVVCTHCPPGQRGRR 785
Query: 826 CNKCLEGNFYLRQNNSFLCLPCN-CDKTGTINGSLL--CNKSTGQC-PCKLGVTGLRCNQ 881
C C +G F PC+ C +G ++ + + C+ +G C C TG C
Sbjct: 786 CEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEH 845
Query: 882 CEPHRYN--LTIDNFQHCQMCECDSLGTLPGTI-CDPISGQCLCVPNRQGRRCNQCQPGF 938
C+ Y L C C C G++ + CDP++GQC C+P+ R C++C PGF
Sbjct: 846 CQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGF 905
Query: 939 Y-ISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTG 997
+ + PG GC C CH G+ C+ TGQC C+ + GQ CD+C+ +FGF +
Sbjct: 906 FDLQPGR--GCRSCKCHPLGSQEDQCHPKTGQCTCRPG-VTGQACDRCQLGFFGFSIKG- 961
Query: 998 RCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDAC 1035
C+ C C GA + CH G C C+ G KCD C
Sbjct: 962 -CRACRCSPLGAASAQCH-ENGTCVCRPGFEGYKCDRC 997
Score = 176 bits (446), Expect = 5e-43
Identities = 117/392 (29%), Positives = 174/392 (44%), Gaps = 42/392 (10%)
Query: 662 CNCKRHVSGRQCNQCQNGFYNLQELDPDG----CSPCNCNTSGTVDGDITCHQNSGQCKC 717
C+C +G+ C C G+ +E+ G C PC CN GT C N+G C C
Sbjct: 673 CSCPTGYTGQFCESCAPGYK--REMPQGGPYASCVPCTCNQHGT------CDPNTGICVC 724
Query: 718 KANVIGLRCDHCNFGF---KFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQC-ECKKEAK 773
+ G C+ C GF F +D C+PC C + C C +
Sbjct: 725 SHHTEGPSCERCLPGFYGNPFAGQADD--CQPCPCPGQSACTTIPESREVVCTHCPPGQR 782
Query: 774 GLQCDTCRENFYGLDV------TNCKACDCDTAGSL-PGTV--CNAKTGQCI-CKPNVEG 823
G +C+ C + F+G + C C C +G++ P V C+ +G C+ C N G
Sbjct: 783 GRRCEVCDDGFFGDPLGLFGHPQPCHQCQC--SGNVDPNAVGNCDPLSGHCLRCLHNTTG 840
Query: 824 RQCNKCLEGNFY---LRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCN 880
C C EG FY L + C+PC+C G+++ + C+ TGQC C VT C+
Sbjct: 841 DHCEHCQEG-FYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCS 899
Query: 881 QCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYI 940
+C P ++L + C+ C+C LG+ C P +GQC C P G+ C++CQ GF+
Sbjct: 900 RCYPGFFDLQPG--RGCRSCKCHPLGSQEDQ-CHPKTGQCTCRPGVTGQACDRCQLGFF- 955
Query: 941 SPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQ 1000
+ GC C C GA + C+ G CVC+ G +CD+C D++F CQ
Sbjct: 956 -GFSIKGCRACRCSPLGAASAQCHE-NGTCVCRPG-FEGYKCDRCHDNFF-LTADGTHCQ 1011
Query: 1001 PCNCHLSGALNETCHLVTGQCFCKQFVTGSKC 1032
C + E L + ++ GS C
Sbjct: 1012 QCPSCYALVKEEAAKLKARLTLTEGWLQGSDC 1043
Score = 173 bits (439), Expect = 4e-42
Identities = 116/372 (31%), Positives = 161/372 (43%), Gaps = 54/372 (14%)
Query: 608 CEHNTTGRNCELCKDYFFRQVG-ADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKR 666
C TG+ CE C + R++ P A C PC C+ GT CD G C C
Sbjct: 675 CPTGYTGQFCESCAPGYKREMPQGGPYAS--CVPCTCNQHGT------CDPNTGICVCSH 726
Query: 667 HVSGRQCNQCQNGFY-NLQELDPDGCSPCNCN-----TSGTVDGDITCHQNSGQCKCKAN 720
H G C +C GFY N D C PC C T+ ++ C C
Sbjct: 727 HTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTH------CPPG 780
Query: 721 VIGLRCDHCNFGFKFLRSFNDV--------GCEPCQCNLHGSVNKF--CNPHSGQC-ECK 769
G RC+ C+ GF F D C CQC+ + N C+P SG C C
Sbjct: 781 QRGRRCEVCDDGF-----FGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCL 835
Query: 770 KEAKGLQCDTCRENFYGLDVT-----NCKACDCDTAGSLPGTV-CNAKTGQCICKPNVEG 823
G C+ C+E FYG + C C C GS+ + C+ TGQC C P+V
Sbjct: 836 HNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTA 895
Query: 824 RQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCE 883
R C++C G F L+ C C C G+ C+ TGQC C+ GVTG C++C+
Sbjct: 896 RDCSRCYPGFFDLQPGRG--CRSCKCHPLGSQEDQ--CHPKTGQCTCRPGVTGQACDRCQ 951
Query: 884 PHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPG 943
+ +I C+ C C LG + +G C+C P +G +C++C F+++
Sbjct: 952 LGFFGFSIKG---CRACRCSPLGAASAQCHE--NGTCVCRPGFEGYKCDRCHDNFFLT-A 1005
Query: 944 NATGCLPC-SCH 954
+ T C C SC+
Sbjct: 1006 DGTHCQQCPSCY 1017
Score = 165 bits (418), Expect = 1e-39
Identities = 101/309 (32%), Positives = 139/309 (44%), Gaps = 32/309 (10%)
Query: 766 CECKKEAKGLQCDTC-----RENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPN 820
C C G C++C RE G +C C C+ G+ C+ TG C+C +
Sbjct: 673 CSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCNQHGT-----CDPNTGICVCSHH 727
Query: 821 VEGRQCNKCLEGNFYLRQNNSFL-----CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVT 875
EG C +CL G FY N F C PC C ++ ++ C G
Sbjct: 728 TEGPSCERCLPG-FY---GNPFAGQADDCQPCPCPGQSACT-TIPESREVVCTHCPPGQR 782
Query: 876 GLRCNQCEPHRYNLTIDNFQHCQMC-ECDSLGTL-PGTI--CDPISGQCL-CVPNRQGRR 930
G RC C+ + + F H Q C +C G + P + CDP+SG CL C+ N G
Sbjct: 783 GRRCEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDH 842
Query: 931 CNQCQPGFY---ISPGNATGCLPCSCHTTGAVNHI--CNSLTGQCVCQDASIAGQRCDQC 985
C CQ GFY ++P A C+PCSCH G+V+ C+ +TGQC C + + C +C
Sbjct: 843 CEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLP-HVTARDCSRC 901
Query: 986 KDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVN 1045
+F P G C+ C CH G+ + CH TGQC C+ VTG CD C +
Sbjct: 902 YPGFFDLQPGRG-CRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIK 960
Query: 1046 NLLGCSKTP 1054
C +P
Sbjct: 961 GCRACRCSP 969
Score = 124 bits (311), Expect = 2e-27
Identities = 77/239 (32%), Positives = 111/239 (46%), Gaps = 25/239 (10%)
Query: 677 QNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFK-- 734
Q+ +Y + + G C CN + G Q + C+C+ N G C+ C F+
Sbjct: 256 QSYYYAVSDFSVGG--RCKCNGHASECGPDVAGQLA--CRCQHNTTGTDCERCLPFFQDR 311
Query: 735 -FLRSFNDVG--CEPCQCNLHGSVNKF------CNPHSGQCE-CKKEAKGLQCDTCRENF 784
+ R + C PC C+ F H G+C C+ G C+ C+ENF
Sbjct: 312 PWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQENF 371
Query: 785 YGLDVTN-CKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFL 843
Y D C+ CDC +AGSL C+ TG C CKP V G +C++CL G L +
Sbjct: 372 YHWDPRMPCQPCDCQSAGSLH-LQCD-DTGTCACKPTVTGWKCDRCLPGFHSLSEGG--- 426
Query: 844 CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCEC 902
C PC C+ G+++ C+ +G+CPCK V G C++C P +NL N C C C
Sbjct: 427 CRPCTCNPAGSLD---TCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFC 482
Score = 115 bits (289), Expect = 9e-25
Identities = 68/221 (30%), Positives = 102/221 (46%), Gaps = 21/221 (9%)
Query: 641 CDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDG-----CSPCN 695
C C+ + G + Q+ C C+ + +G C +C F + C PCN
Sbjct: 271 CKCNGHASECGPDVAGQLA--CRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCN 328
Query: 696 CNTSG---TVDGDI---TCHQNSGQCK-CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQ 748
C+ T D ++ T H G+C C+ + G C+ C F + C+PC
Sbjct: 329 CSGRSEECTFDRELFRSTGH--GGRCHHCRDHTAGPHCERCQENFYHWDP--RMPCQPCD 384
Query: 749 CNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVC 808
C GS++ C+ +G C CK G +CD C F+ L C+ C C+ AGSL C
Sbjct: 385 CQSAGSLHLQCDD-TGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLD--TC 441
Query: 809 NAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNC 849
+ ++G+C CK NVEG C++C G F L+ +N C C C
Sbjct: 442 DPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFC 482
Score = 109 bits (272), Expect = 8e-23
Identities = 73/228 (32%), Positives = 107/228 (46%), Gaps = 35/228 (15%)
Query: 747 CQCNLHGSVNKFCNPH-SGQ--CECKKEAKGLQCDTCRENFYGLD--------VTNCKAC 795
C+CN H S C P +GQ C C+ G C+ C F C C
Sbjct: 271 CKCNGHASE---CGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPC 327
Query: 796 DCDTAGSLPGTVCNAKT-------GQCI-CKPNVEGRQCNKCLEGNFYLRQNNSFLCLPC 847
+C +G + + G+C C+ + G C +C E NFY + C PC
Sbjct: 328 NC--SGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQE-NFY-HWDPRMPCQPC 383
Query: 848 NCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGT 907
+C G+++ L C+ TG C CK VTG +C++C P ++L+ C+ C C+ G+
Sbjct: 384 DCQSAGSLH--LQCD-DTGTCACKPTVTGWKCDRCLPGFHSLSEGG---CRPCTCNPAGS 437
Query: 908 LPGTICDPISGQCLCVPNRQGRRCNQCQPG-FYISPGNATGCLPCSCH 954
L CDP SG+C C N +G C++C+PG F + P N GC C C+
Sbjct: 438 L--DTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCY 483
Score = 95.5 bits (236), Expect = 1e-18
Identities = 59/195 (30%), Positives = 89/195 (45%), Gaps = 17/195 (8%)
Query: 868 CPCKLGVTGLRCNQCEPHRYNL-----TIDNFQHCQMCECDSLG---TLPGTICDPIS-- 917
C C+ TG C +C P + T + C C C T +
Sbjct: 290 CRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHG 349
Query: 918 GQCL-CVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDAS 976
G+C C + G C +CQ FY C PC C + G+++ C+ TG C C+ +
Sbjct: 350 GRCHHCRDHTAGPHCERCQENFYHWDPRMP-CQPCDCQSAGSLHLQCDD-TGTCACKP-T 406
Query: 977 IAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACV 1036
+ G +CD+C + G C+PC C+ +G+L +TC +G+C CK+ V G+ CD C
Sbjct: 407 VTGWKCDRCLPGFHSLSE--GGCRPCTCNPAGSL-DTCDPRSGRCPCKENVEGNLCDRCR 463
Query: 1037 PSASHLDVNNLLGCS 1051
P +L +N GCS
Sbjct: 464 PGTFNLQPHNPAGCS 478
Score = 87.0 bits (214), Expect = 4e-16
Identities = 59/184 (32%), Positives = 86/184 (46%), Gaps = 23/184 (12%)
Query: 887 YNLTIDNFQHCQMCECDSLGTLPGTICDP-ISGQ--CLCVPNRQGRRCNQCQPGFYISP- 942
Y + +F C+C+ + C P ++GQ C C N G C +C P F P
Sbjct: 258 YYYAVSDFSVGGRCKCNG----HASECGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPW 313
Query: 943 --GNATG---CLPCSCHTTGAVNHICNSLT------GQCV-CQDASIAGQRCDQCKDHYF 990
G A CLPC+C L G+C C+D + AG C++C+++++
Sbjct: 314 ARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGGRCHHCRDHT-AGPHCERCQENFY 372
Query: 991 GFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGC 1050
+DP+ CQPC+C +G+L+ C TG C CK VTG KCD C+P L C
Sbjct: 373 HWDPRMP-CQPCDCQSAGSLHLQCD-DTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPC 430
Query: 1051 SKTP 1054
+ P
Sbjct: 431 TCNP 434
Score = 39.7 bits (91), Expect = 0.079
Identities = 26/70 (37%), Positives = 30/70 (42%), Gaps = 13/70 (18%)
Query: 518 CQCH--GHADNCDTTSQPYRCLCSQESFTEGLHCDRCLP-LYNDKPFRQGDQVYAFNCKP 574
C C+ G D CD S RC C + EG CDRC P +N +P C
Sbjct: 430 CTCNPAGSLDTCDPRSG--RCPCKEN--VEGNLCDRCRPGTFNLQPHNPA------GCSS 479
Query: 575 CQCNSHSKSC 584
C C HSK C
Sbjct: 480 CFCYGHSKVC 489
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 209 bits (533), Expect = 4e-53
Identities = 345/1465 (23%), Positives = 581/1465 (39%), Gaps = 221/1465 (15%)
Query: 3745 YTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPG------- 3797
YT ++ + GG S S V+ PE +P ++ + +I + W P
Sbjct: 567 YTCRV-ISAGGNDSRSAHLRVRQLPHAPE--HPVATLSTVERRAINLTWTKPFDGNSPLI 623
Query: 3798 ---ILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGV 3854
+ + E + VLL SV P A SV ++ L P Y+ R+ A + G
Sbjct: 624 RYILEMSENNAPWTVLL--ASVDPKATSV------TVKGLVPARSYQFRLCAVNDVGKGQ 675
Query: 3855 SSRMF--VKTPEAAPMDLNSPVLKALGSA----CIEIKWMPPEKPN------GIIINYFI 3902
S+ V PE P +P + S I I+W PP + + G II Y +
Sbjct: 676 FSKDTERVSLPEEPP---TAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCL 732
Query: 3903 YRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKG-----SVESLWSL 3957
P G + +++ L + L +T YE V A NS G S + W+L
Sbjct: 733 AGLPVGYQFKNITDADVNNLLL-----EDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTL 787
Query: 3958 TQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESP--NGIISHYRVVYQERPDDPTFNSPT 4015
PP + A +AT++ ++ W P NGI Y+++ E + T
Sbjct: 788 QGVPTVPPGNVHA---EATNSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVT 844
Query: 4016 VHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGE-ILSPWTLIQTLESSPSGLRNFIV 4074
+ + H + GL+ FT Y V+ G+ S L++T E P + +
Sbjct: 845 ARP-NFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSF 903
Query: 4075 EQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNR-----------QFLFRRLD 4123
+ + +L + W EP NG++ Y I + EY+ N ++ L
Sbjct: 904 SEILD-TSLKVSWQEPGEKNGILTGYRI---SWEEYNRTNTRVTHYLPNVTLEYRVTGLT 959
Query: 4124 PFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPT---VHSVKSTSVELSWSEPVN 4180
T YT+ + A T G + + + PP+ PT + ++ SV L + +
Sbjct: 960 ALTTYTIEVAAMTSKGQGQVSASTI-SSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYD 1018
Query: 4181 PNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKI 4240
I R+ V +A + +E ++ + + E + L P+T +++
Sbjct: 1019 GKTSISRWLV-------EAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRM 1071
Query: 4241 YTWNSAGHTCSSW--NVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIP-PEQS-NGIIQ 4296
N G + S ++TLQAPP+ ++P +S + + L + W+P PE NG +
Sbjct: 1072 RQVNIVGTSPPSQPSRKIQTLQAPPD-MAPANVSLRTASETSLWLRWMPLPEMEYNGNPE 1130
Query: 4297 S--YRLQ------RNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKPTS 4348
S Y+++ + L D V +YT E+L ++ Y +QA + G T
Sbjct: 1131 SVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTV 1190
Query: 4349 I-TTLEAAPSEVSPPDLWAVSATQ--MNVCWS--PPTVQNGKITKYLVRYDNKESLAGQG 4403
+ T E+ PS P ++ A++ T M V WS P +NG + Y V Y K+S
Sbjct: 1191 VGRTRESVPSS-GPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPR 1249
Query: 4404 LCLL---------VSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTLQV 4454
L+ ++ L Y Y ++A T G S S +E +++ P + +
Sbjct: 1250 FWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIG-DGSPSHPP-ILERTLDDVPGPPMGI 1307
Query: 4455 TGSE----SIEITWKPPRNPNGQIRSYEL--RRDGTIVYTG----LETRYRDFTLT---P 4501
E S+ + W+PP PNG I +Y++ R + T T L R +T T P
Sbjct: 1308 LFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKP 1367
Query: 4502 GVEYSYTVTASNSQGG-------ILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDP 4554
Y + +TA +G +++ +DR P + ++ ++AR +L++W+P
Sbjct: 1368 ESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARS---VLLSWEP 1424
Query: 4555 PVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTT 4614
+ YT+ REL + + +HN+ S+IV++LKPF Y+ R++A
Sbjct: 1425 GSDGLSPVRYYTIQTRELPSGRWALHSASVSHNA---SSFIVDRLKPFTSYKFRVKATND 1481
Query: 4615 LGCASSDWTFIQTPEIAPLMQPPPHLEVQMAPGGFQPTVSLL--WTGPLQP--NGKVLYY 4670
+G D F + E +Q P + T S+L W P + NG +L +
Sbjct: 1482 IG----DSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGF 1537
Query: 4671 ELYRRQI-----------------ATQPRKSNPVLIYNGSSTSFIDSELLPFTE---YEY 4710
+ R++ AT ++ + N S S EL + YE
Sbjct: 1538 RIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEI 1597
Query: 4711 QVWAVNSAGKAPSSWTW-CRTGPAPPEGL-RAPTFHVISSTQAVVNISAP--GKPNGIVS 4766
++ N+ G+ PSS G A P R H ++TQ V P NG +
Sbjct: 1598 RMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQ 1657
Query: 4767 LYRLFSSSAHGAETVLSEGMAT------QQTLHGLQAFTNYSIGVEACTCFNCCSKGPTA 4820
Y+++ A L+E + T L L +T Y + V A FN GP +
Sbjct: 1658 GYKIYFWEAQRGN--LTERVKTLFLAENSVKLKNLTGYTAYMVSVAA---FNAAGDGPRS 1712
Query: 4821 ---ELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALP 4877
+ +T A PS SS + L + + + W P FPNG++ Y L + P
Sbjct: 1713 TPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYE---------P 1763
Query: 4878 CTPSQIETKYTGLGQKAS------LGGLQPYTTYKLRVVAHN-EVGSTASEWISFTTQKE 4930
C+P +K + K + + L TY+ R+ A G ++ +
Sbjct: 1764 CSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEG 1823
Query: 4931 LPQYRAPFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLY--IPRTAD 4988
P + S + ++WS G + YV+ R GL L IP+
Sbjct: 1824 APGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIE--ARPSDEGLWDILIKDIPK--- 1878
Query: 4989 KTFFFQVICTTDEGSVKTPLIQYD------TSTGLGLVLTTPGKKKGS--RSKSTEFYSE 5040
+V T + P + YD G G TP S K+ FY E
Sbjct: 1879 -----EVSSYTFSMDILKPGVSYDFRVIAVNDYGFG----TPSSPSQSVPAQKANPFYEE 1929
Query: 5041 LWFIVLMAMLGLILLAIFLSLILQR 5065
WF+V++A++GLI + + + +++ R
Sbjct: 1930 WWFLVVIALVGLIFILLLVFVLIIR 1954
Score = 176 bits (447), Expect = 4e-43
Identities = 304/1299 (23%), Positives = 510/1299 (39%), Gaps = 182/1299 (14%)
Query: 3460 SYTDVNLKPYMTYEYRISAWNSYGRG-LSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIV 3518
S T L P +Y++R+ A N G+G SK + + P P +I+
Sbjct: 649 SVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRTNQSIM 708
Query: 3519 LNWRKPIQSN------GPIIYYIL--LRNGIERFRGTSLSFSD--KEGIQPFQEYSYQLK 3568
+ W+ P +S+ G II Y L L G + T ++ E + + Y ++
Sbjct: 709 IQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVA 768
Query: 3569 ACTVAGCAT-SSKVVAATTQGVPESILPPS---ITALSAVALHLSWSVPEKS--NGVIKE 3622
A AG SSKV T QGVP +PP A ++ + +W+ P NG+ +
Sbjct: 769 AYNSAGLGVYSSKVTEWTLQGVP--TVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQG 826
Query: 3623 YQI--------RQVGKGLIHTDTTDR-RQHTVTGLQPYTNYSFTLTAC--TSAGCTSSEP 3671
Y++ +V + D V+GL+ +T Y FT C T S P
Sbjct: 827 YKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEY-FTSVLCFTTPGDGPRSTP 885
Query: 3672 FLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLS------RNGNLLF 3725
L +T + P V I++ T++++ W P + NG+++ Y++S N +
Sbjct: 886 QLVRTHEDVPGPVGHLSFSEILD-TSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRVTH 944
Query: 3726 LGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITV-- 3783
+ + L + YT ++ T G + + + PE PP N+ +
Sbjct: 945 YLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGV-PPELPGPPTNLGISN 1003
Query: 3784 IGPYSIFVAWIP---PGILIPEIPVEYNV-LLNDGSVTPLAFSVGHH---QSTLLENLTP 3836
IGP S+ + + P I VE V ++ +G L + + +S + +L P
Sbjct: 1004 IGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNP 1063
Query: 3837 FTQYEIRIQACQNGSCGVSSRMFVK------TPEAAPMDLNSPVLKALGSACIEIKWMP- 3889
FT Y R++ S+ K P+ AP +++ L+ + ++WMP
Sbjct: 1064 FTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAPANVS---LRTASETSLWLRWMPL 1120
Query: 3890 PE---KPNGIIINYFI-YRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRAC 3945
PE N + Y I Y R G + V ++ E L +T Y +V+A
Sbjct: 1121 PEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVERDYTIE--DLEEWTEYRVQVQAF 1178
Query: 3946 NSKGSVESLWSLT---QTLEAPPQDFPA-PWAQATSAHSVLLNWTK-PESP-NGIISHYR 3999
N+ GS WS T +T E+ P P A AT++ S+L+ W++ PE+ NG++ Y+
Sbjct: 1179 NAIGS--GPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYK 1236
Query: 4000 VVYQERPDD--PTFNSPTVHAFTVKG-TSHQAHLYGLEPFTTYRIGVVAANHAGE--ILS 4054
V+Y+E+ D P F + V+G +S A L GL + Y + V+A G+
Sbjct: 1237 VMYKEKDSDTQPRF-------WLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSH 1289
Query: 4055 PWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLN 4114
P L +TL+ P + + L+ W P NG+I Y I L + N
Sbjct: 1290 PPILERTLDDVPGPPMGILFPEVRTTSVRLI-WQPPAAPNGIILAYQITHR--LNTTTAN 1346
Query: 4115 -----------RQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWT----DEAPPDSQL 4159
RQ+ L P ++Y + A TR G +A + T D P S+
Sbjct: 1347 TATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRP 1406
Query: 4160 APTVHSVKSTSVELSWSEPVNPNGKIIRYEVIR-RCFEGKAWGNQTIQADEKIVFTEYNT 4218
V++ SV LSW EP + +RY I+ R W + +
Sbjct: 1407 MVQQEDVRARSVLLSW-EPGSDGLSPVRYYTIQTRELPSGRWALHSA-----------SV 1454
Query: 4219 ERNTFMYNDTGLQPWTQCEYKIYTWNSAGHT--CSSWNVVRTLQAPPEGLSPPVISYVSM 4276
N + L+P+T ++++ N G + + TLQA P+ +P ++S
Sbjct: 1455 SHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDE-APTILSVTPH 1513
Query: 4277 NPQKLLISWIPP--EQSNGIIQSYRLQRNEMLYP--------------FSFDPVTFNYTD 4320
+LI W PP ++ NGI+ +R++ E+LY ++ +T Y+
Sbjct: 1514 TTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGATWAELTSMYSM 1573
Query: 4321 EELLPFSTYSYALQACTS--------------GGCSTSKPTSITTLEAAPSEVSPPD--L 4364
L S Y L G +S P + EA P+ +P + +
Sbjct: 1574 RNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPT-AAPRNVVV 1632
Query: 4365 WAVSATQMNVCWSPPTV--QNGKITKYLVRY---------DNKESLAGQGLCLLVSHLQP 4413
+ATQ++V W PP + QNG I Y + + + ++L + + +L
Sbjct: 1633 HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTG 1692
Query: 4414 YSQYNFSLVACTNGG-CTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRNPNG 4472
Y+ Y S+ A G S T +A P S + S+ ++W+ P+ PNG
Sbjct: 1693 YTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752
Query: 4473 QIRSYEL------RRDGTIVYTGLETR------YRDFTLTPGVEYSYTVTASNSQGGILS 4520
+ Y L DG ++ + + L GV Y + + A G
Sbjct: 1753 ILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYG--- 1809
Query: 4521 PLVKDRTSPSAPSGMEPP---KLQARGPQEILVNWDPPVRTNGDIINYTLFIRELFERET 4577
P ++ + G P + R I ++W G I Y + R E
Sbjct: 1810 PEIEANVTTGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSDEGLW 1869
Query: 4578 KIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLG 4616
I+ I ++ ++ LKP Y+ R+ A G
Sbjct: 1870 DIL-IKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYG 1907
Score = 172 bits (436), Expect = 8e-42
Identities = 329/1409 (23%), Positives = 526/1409 (37%), Gaps = 216/1409 (15%)
Query: 3471 TYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKPIQSNGP 3530
TY R+ S G S++ R ++ +P P T I L W KP N P
Sbjct: 566 TYTCRVI---SAGGNDSRSAHLRVRQ-LPHAPEHPVATLSTVERRAINLTWTKPFDGNSP 621
Query: 3531 IIYYILLRNGIERFRGTSLSFSDK-------EGIQPFQEYSYQLKACTVAGCATSSKVVA 3583
+I YIL + L+ D +G+ P + Y ++L A G SK
Sbjct: 622 LIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTE 681
Query: 3584 ATTQGVPESILPPSITALSA---VALHLSWSVPEKS--NGVIKEYQIR------QVGKGL 3632
+ PP S ++ + W P +S NG++K Y IR VG
Sbjct: 682 RVSLPEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQF 741
Query: 3633 IHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGC-TSSEPFLGQTLQAAPEGVWVTPRHI 3691
+ D + L +TNY + A SAG S TLQ P V P ++
Sbjct: 742 KNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPT---VPPGNV 798
Query: 3692 ---IINSTTVELYWSLPEKP--NGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSR-- 3744
NSTT+ W+ P NG+ Y+ L+ +E+ T PN +
Sbjct: 799 HAEATNSTTIRFTWNAPSPQFINGINQGYK------LIAWEPEQEEEVTMVTARPNFQDS 852
Query: 3745 ---------------YTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGPYSI 3789
+T L T G S +V+T P + + + I S+
Sbjct: 853 IHVGFVSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPV-GHLSFSEILDTSL 911
Query: 3790 FVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFS-----VGHHQSTL-----LENLTPFTQ 3839
V+W PG E N +L ++ ++ V H+ + + LT T
Sbjct: 912 KVSWQEPG--------EKNGILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTT 963
Query: 3840 YEIRIQACQNGSCGVSSRMFVKT--PEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGII 3897
Y I + A + G S + + P P + + +G + +++ P I
Sbjct: 964 YTIEVAAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFRPGYDGKTSI 1023
Query: 3898 INYFIYRR--PAGIEEESVLF--VWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGS--V 3951
+ + + G EE +L + +E M+ D L PFT Y +R+R N G+
Sbjct: 1024 SRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPD-LNPFTCYSFRMRQVNIVGTSPP 1082
Query: 3952 ESLWSLTQTLEAPPQDFPAPWAQATSAH-SVLLNWTK-PE---SPNGIISHYRVVYQERP 4006
QTL+APP PA + T++ S+ L W PE + N Y++ Y R
Sbjct: 1083 SQPSRKIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKY-SRS 1141
Query: 4007 DDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWT---LIQTLE 4063
D + T+ + LE +T YR+ V A N G PW+ + +T E
Sbjct: 1142 DG---HGKTLSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGS--GPWSQTVVGRTRE 1196
Query: 4064 SSPSGLRNFIVEQKENGRALLLQWSEPMRT--NGVIKTYNIF-----SDG----FLEYSG 4112
S PS + ++L++WSE NG++ Y + SD +L
Sbjct: 1197 SVPSSGPTNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGN 1256
Query: 4113 LNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLW--TDEAPPDSQLAPTVHSVKSTS 4170
+R L + LY + + A TR G + P+ T + P + V++TS
Sbjct: 1257 SSRSAQLTGLGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTS 1316
Query: 4171 VELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGL 4230
V L W P PNG I+ Y++ R T A+ V + R Y TGL
Sbjct: 1317 VRLIWQPPAAPNGIILAYQITHRL--------NTTTANTATVEVLAPSAR---QYTATGL 1365
Query: 4231 QPWTQCEYKI--YTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIPP 4288
+P + ++I T G + V + P+ S P++ + + +L+SW P
Sbjct: 1366 KPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPG 1425
Query: 4289 EQSNGIIQSYRLQRNEM------LYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCS 4342
++ Y +Q E+ L+ S ++ + L PF++Y + ++A G S
Sbjct: 1426 SDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDS 1485
Query: 4343 --TSKPTSITTLEAAPSEVSPPDLWAV---SATQMNVCWSPPTVQ--NGKITKYLVRYDN 4395
+ + S+TTL+AAP E P + +V + T + + W PP NG + + +RY
Sbjct: 1486 EFSEESESLTTLQAAPDEA--PTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRE 1543
Query: 4396 --KESLAGQGL-------CLLVSHLQPYSQYNFSLVACT-------NGGCTASVSKSAWT 4439
E L G L YS N S + T N + S +
Sbjct: 1544 LLYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVY- 1602
Query: 4440 MEALPENMDSPTLQVTGSESI------------------EITWKPP--RNPNGQIRSYEL 4479
A+ E SP +V E++ ++TW+PP + NG I+ Y++
Sbjct: 1603 -NAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKI 1661
Query: 4480 -----------RRDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDRT 4527
R T+ + ++ LT Y +V A N+ G G S + +T
Sbjct: 1662 YFWEAQRGNLTERVKTLFLAENSVKLKN--LTGYTAYMVSVAAFNAAGDGPRSTPTQGQT 1719
Query: 4528 SPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIINYTLFIREL--FERETKIIHINTT 4585
+APS K + V+W+ P NG + Y L + +KI+ ++
Sbjct: 1720 QQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVK 1779
Query: 4586 HNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSDWTFIQTPEIAPLMQPPPHLEVQMA 4645
NS V L Y RI+A TF PEI + P
Sbjct: 1780 GNS--PLWLKVKDLAEGVTYRFRIRA----------KTFTYGPEIEANVTTGPGEGAPGP 1827
Query: 4646 PG-----GFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYN----GSSTS 4696
PG + +++ W+ G + Y + R +LI + SS +
Sbjct: 1828 PGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEAR---PSDEGLWDILIKDIPKEVSSYT 1884
Query: 4697 FIDSELLPFTEYEYQVWAVNSAG-KAPSS 4724
F L P Y+++V AVN G PSS
Sbjct: 1885 FSMDILKPGVSYDFRVIAVNDYGFGTPSS 1913
Score = 147 bits (370), Expect = 4e-34
Identities = 292/1249 (23%), Positives = 471/1249 (37%), Gaps = 174/1249 (13%)
Query: 2038 AGCTESSHA-LNISTPQEAPQEVQPPVAKSLPSSLLLSWNPPKKANGIITQYCLYMDGR- 2095
AG +S A L + AP+ ++ ++ L+W P N + +Y L M
Sbjct: 574 AGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENN 633
Query: 2096 -----LIYSGSEE--NYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDS 2148
L+ S + + TV L +QF L A VG S LP E +
Sbjct: 634 APWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT-ERVSLPEEPPTA 692
Query: 2149 PVLTVLDS----RTIHIQWKQPRKI--SGILERYVLYMSNHTHDFTIWSVIYNSTELFQD 2202
P V+ S ++I IQW+ P + +GIL+ Y++ + N T+ +
Sbjct: 693 PPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYC--LAGLPVGYQFKNITDADVN 750
Query: 2203 HML-QYVLPGNKYLIKLGACTGGGCTV-SEASEALTDEDIPEGVPAPKAHSYSPDSFNVS 2260
++L + ++ Y I++ A G V S T + +P VP H+ + +S +
Sbjct: 751 NLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPT-VPPGNVHAEATNSTTIR 809
Query: 2261 WT----EPEYPNGVITSYGL-------------------YLDGILIHNSSELSYRAYGFA 2297
+T P++ NG+ Y L + D I + S G
Sbjct: 810 FTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVS-------GLK 862
Query: 2298 PWSLHSFRVQACTAKGCALGP-----LVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAP 2352
++ + V T G GP LV P G ++ S K V W+ P
Sbjct: 863 KFTEYFTSVLCFTTPGD--GPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLK--VSWQEP 918
Query: 2353 FRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQV 2412
NG+LT + Y N T+V + L + GL T YT++V
Sbjct: 919 GEKNGILTGYRISW---------EEYNRTN-TRVTHYLPNVTLEYRVTGLTALTTYTIEV 968
Query: 2413 NI--SNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQ 2470
S QG + I+ +PP P +S+ P S+ + + P + R+
Sbjct: 969 AAMTSKGQGQVSASTISSGVPPELPGPPTNLGISNIGPRSVTLQFR-PGYDGKTSISRWL 1027
Query: 2471 LQMRSGDSTHG----FLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPF 2526
++ + G G + SN + S EV DL P+T Y FR+ N G++ S
Sbjct: 1028 VEAQVGVVGEGEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSR 1087
Query: 2527 MTAEDKPGPVVPPILLDVKSRMMLVTW-------QHPRKSNGVITHYNI-YLHGRLYLRT 2578
+ P + P + +++ W + N Y I Y + +T
Sbjct: 1088 KIQTLQAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKT 1147
Query: 2579 PGNVT------NCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIPSP-- 2630
+V + T+ L +T Y+ QV+A + G P SQTV + E +PS
Sbjct: 1148 LSHVVQDRVERDYTIEDLEEWTEYRVQVQAFNAIGSG--PWSQTV--VGRTRESVPSSGP 1203
Query: 2631 ---ELFSDTPTSVIISWQ--PPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFID 2685
+ T +S+++ W P NGLV + + + K + L +S R
Sbjct: 1204 TNVSALATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRF-WLVEGNSSRSAQ 1262
Query: 2686 KTSALSPWTKYEYRVLMSTLHG-GTNSSAWVEVTTR---PSRPAGVQPPVVTVLEPDAVQ 2741
T L + YE +VL T G G+ S + T P P G+ P V +V+
Sbjct: 1263 LTG-LGKYVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTT---SVR 1318
Query: 2742 VTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQKV-----THLIPFTNYSVTIVAC 2796
+ W+PP NG IL+Y+I T T VL+ T L P + Y I A
Sbjct: 1319 LIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQ 1378
Query: 2797 SGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESY----VVISWQPPSKPNGPNL 2852
+ G E+ V T + P + E V++SW+P S P
Sbjct: 1379 TRK-----GWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVR 1433
Query: 2853 RYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTP 2912
Y + R++ P + HN S + L FT+Y++ + N +G +
Sbjct: 1434 YYTIQTREL--PSGRWALHSASVSHNASS-----FIVDRLKPFTSYKFRVKATNDIGDSE 1486
Query: 2913 SREVT--VTTLAGLPERGANLTASVLNHTAIDV--RWAKPTVQDLQG-----EVEYYTLF 2963
E + +TTL P+ + SV HT V RW P + G + Y L
Sbjct: 1487 FSEESESLTTLQAAPDEAPTIL-SVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELL 1545
Query: 2964 ------------------WSSATSNDSLKIL--PDVNSHVIGHLKPNTEYWIFISVFNGV 3003
W+ TS S++ L P + + + +L + Y I +SV+N V
Sbjct: 1546 YEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAV 1605
Query: 3004 HSINSAGLHATTCDGEPQGMLPPEVVIINSTAVR--VIWTSP--SNPNGVVTEYSIYV-- 3057
S+ P VV+ +TA + V W P + NG + Y IY
Sbjct: 1606 GEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWE 1665
Query: 3058 -----NNKLYKTGMNVPGSFILRDLSPFTIYDIQVEVCTIYAC-VKSNGTQITTVEDTPS 3111
+ KT S L++L+ +T Y + V +S TQ T + PS
Sbjct: 1666 AQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPS 1725
Query: 3112 DIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLV 3160
+ +T+ S+ + W +P+ PNGI+ GY L+++ P K+V
Sbjct: 1726 APSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIV 1774
Score = 135 bits (339), Expect = 1e-30
Identities = 288/1280 (22%), Positives = 481/1280 (37%), Gaps = 202/1280 (15%)
Query: 1912 KEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTTGAAPQSVPT--PSRV--RSLN 1967
K SV GL P Y +R+ A ++ G +S+ + P+ PT P V
Sbjct: 646 KATSVTVKGLVPARSYQFRLCAVNDVGK--GQFSKDTERVSLPEEPPTAPPQNVIASGRT 703
Query: 1968 GYSIEVTWDEP-------VVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILT 2020
SI + W P +++G I +Y L P + + +NL +L
Sbjct: 704 NQSIMIQWQPPPESHQNGILKGYIIRYCLAGL------PVGYQFKNITDADVNNL--LLE 755
Query: 2021 GLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKSLPSSLLL--SWNPP 2078
L+ + NY + + A AG S + T Q P V +S + +WN P
Sbjct: 756 DLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAP 815
Query: 2079 KKA--NGIITQYCLY------------MDGRLIYSGSEENYTVTDLAVFTPHQFLLSACT 2124
NGI Y L + R + S V+ L FT + + T
Sbjct: 816 SPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFT 875
Query: 2125 HVGCTNSSWVLLYTAQLPPEHVDSP-------VLTVLDSRTIHIQWKQPRKISGILERYV 2177
G S T QL H D P +LD+ ++ + W++P + +GIL Y
Sbjct: 876 TPGDGPRS-----TPQLVRTHEDVPGPVGHLSFSEILDT-SLKVSWQEPGEKNGILTGYR 929
Query: 2178 LYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPG----NKYLIKLGACTGGGCTVSEASE 2233
+ + T T + L+Y + G Y I++ A T G + S
Sbjct: 930 ISWEEYNRTNT------RVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKG--QGQVSA 981
Query: 2234 ALTDEDIPEGVPAPKAH----SYSPDSFNVSWTEPEYPNGVITS-------YGLYLDG-- 2280
+ +P +P P + + P S + + P Y S G+ +G
Sbjct: 982 STISSGVPPELPGPPTNLGISNIGPRSVTLQF-RPGYDGKTSISRWLVEAQVGVVGEGEE 1040
Query: 2281 -ILIHNSSE----LSYRAYGFAPWSLHSFRVQACTAKGCA--LGPLVENRTLEAPPE-GT 2332
+LIH S S P++ +SFR++ G + P + +TL+APP+
Sbjct: 1041 WLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAP 1100
Query: 2333 VNVFVKTQGSRKAHVRW----EAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMY 2388
NV ++T +RW E + N SV + I Y G+ TL +V +
Sbjct: 1101 ANVSLRTASETSLWLRWMPLPEMEYNGN---PESVGYK-IKYSRSDGHGKTLSHVVQDRV 1156
Query: 2389 SGEETNLWVLIDGLVPFTNYTVQVNISNSQGS-----LITDPITIAMPPGAPDGVLPPRL 2443
+ T I+ L +T Y VQV N+ GS + ++P P V
Sbjct: 1157 ERDYT-----IEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNV---SA 1208
Query: 2444 SSATPTSLQVVWSTPARNNAPGSPR-YQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQP 2502
+ T +S+ V WS + G Y++ + DS ++S S +++ L
Sbjct: 1209 LATTSSSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGK 1268
Query: 2503 YTEYMFRLVASNGFGSAHSSWIPFM--TAEDKPGPVVPPILLDVKSRMMLVTWQHPRKSN 2560
Y Y +++A G S P + T +D PGP + + +V++ + + WQ P N
Sbjct: 1269 YVLYEVQVLAFTRIGDGSPSHPPILERTLDDVPGPPMGILFPEVRTTSVRLIWQPPAAPN 1328
Query: 2561 GVITHYNIYLHGRLYLRTPGNVT---------NCTVMHLHPYTAYKFQVEACTSKGCSLS 2611
G+I Y I RL T T T L P + Y F++ A T KG +
Sbjct: 1329 GIILAYQI--THRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEA 1386
Query: 2612 PESQTVWTLP---GAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIE-RRVKGKE 2667
E+ V T P P + SV++SW+P + V +TI+ R +
Sbjct: 1387 AEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGR 1446
Query: 2668 EVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGV 2727
++ + S +D+ L P+T Y++RV + G + S E T
Sbjct: 1447 WALHSASVSHNASSFIVDR---LKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDE 1503
Query: 2728 QPPVVTVL--EPDAVQVTWKPPLIQ--NGDILSYEIH----------------MPDPHIT 2767
P +++V +V + W+PP NG +L + I + +P T
Sbjct: 1504 APTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGAT 1563
Query: 2768 LTNVTS----------AVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTH 2817
+TS ++ ++ +L Y + + + +G S P V
Sbjct: 1564 WAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNA----VGEGPSSPPQEVFVG 1619
Query: 2818 PTVPQNVGPLSVI--PLSESYVVISWQPP--SKPNGPNLRYELLRRKIQQPLASNPPEDL 2873
VP P +V+ + + + ++W+PP NG Y++ + Q+ N E +
Sbjct: 1620 EAVP-TAAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQR---GNLTERV 1675
Query: 2874 NRWHNIYSGTQWLYED----KGLSRFTTYEYMLFVHNSVGFTP-SREVTVTTLAGLPERG 2928
T +L E+ K L+ +T Y + N+ G P S T P
Sbjct: 1676 K--------TLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAP 1727
Query: 2929 ANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLK 2988
+++ S L T+++V W P Q G +E Y L + + D + + V+ +K
Sbjct: 1728 SSVKFSELTTTSVNVSWEAP--QFPNGILEGYRLVYEPCSPVDGVSKIVTVD------VK 1779
Query: 2989 PNTEYWIFI-SVFNGV---------HSINSAGLHATTCDGEPQGML-PPEVVII--NSTA 3035
N+ W+ + + GV + A G +G PP V II S+A
Sbjct: 1780 GNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRYSSA 1839
Query: 3036 VRVIWTSPSNPNGVVTEYSI 3055
+ + W+S G +T Y I
Sbjct: 1840 IAIHWSSGDPGKGPITRYVI 1859
Score = 94.7 bits (234), Expect = 2e-18
Identities = 115/476 (24%), Positives = 197/476 (41%), Gaps = 51/476 (10%)
Query: 1059 PPRG----QVQSSSAINLSWSPPDSPN----AHWLTYSLLRDGFEIYTTEDQYPYSIQYF 1110
PP G +V+++S + L W PP +PN A+ +T+ L T E P + QY
Sbjct: 1303 PPMGILFPEVRTTS-VRLIWQPPAAPNGIILAYQITHRLNTTTANTATVEVLAPSARQYT 1361
Query: 1111 LDTDLLPYTKYSYYIETTNVHG---STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTL 1167
T L P + Y + I G + ++ VT + + + + + + SV L
Sbjct: 1362 A-TGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLL 1420
Query: 1168 TWTTLSNQSGPIEKYILSCAPLAGGQPCV---SYEGHETSATIWNLVPFAKYDFSVQACT 1224
+W S+ P+ Y + L G+ + S + +S + L PF Y F V+A
Sbjct: 1421 SWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATN 1480
Query: 1225 SGGC--LHSLPITVTTAQAPPQRLSPPKMQKIS---STELHVEWSPPAE--LNGIIIRYE 1277
G ++TT QA P P + ++ +T + + W PPAE +NGI++ +
Sbjct: 1481 DIGDSEFSEESESLTTLQAAPDEA--PTILSVTPHTTTSVLIRWQPPAEDKINGILLGFR 1538
Query: 1278 LYMRRLRSTKETTSEESRVFQSSGWLSPHS-FVESAN----ENALKPPQTMTTITGLEPY 1332
+ R L E R F G +P + + E + N +P T + L +
Sbjct: 1539 IRYREL------LYEGLRGFTLRGINNPGATWAELTSMYSMRNLSRPSLTQYELDNLNKH 1592
Query: 1333 TKYEFRVLAVNMAGSVSSA-----WVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPAD 1387
+YE R+ N G S+ +V E +AP ++ V ++ L+++WE P
Sbjct: 1593 RRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVV---VHGATATQLDVTWEPPPL 1649
Query: 1388 NVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLC 1447
+ G + GY I Q ++ + T E S ++ L Y Y ++
Sbjct: 1650 DSQNGDIQGYKIYFWEAQRGN------LTERVKTLFLAENSVKLKNLTGYTAYMVSVAAF 1703
Query: 1448 NSVGC-VTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQL 1502
N+ G S GQT AAP+ + +T++++ W P+ NG Y+L
Sbjct: 1704 NAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRL 1759
Score = 90.9 bits (224), Expect = 3e-17
Identities = 199/914 (21%), Positives = 335/914 (36%), Gaps = 117/914 (12%)
Query: 1902 GNDSILVYQGKEQ----SVYEGGLQPFTEYLYRVIASH-EGGSVYSDWSRG-RTTGAAPQ 1955
G + +L++Q + S+ L PFT Y +R+ + G S S SR +T A P
Sbjct: 1038 GEEWLLIHQLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPD 1097
Query: 1956 SVPTPSRVRSLNGYSIEVTW---DEPVVRGVIEKYILKA-YSEDSTRPPRMPSASAEFVN 2011
P +R+ + S+ + W E G E K YS + + V
Sbjct: 1098 MAPANVSLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHVVQDRVE 1157
Query: 2012 TSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHAL----NISTPQEAPQEVQPPVAKSL 2067
+ L + Y V + A G S + S P P V S
Sbjct: 1158 RDYT---IEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTS- 1213
Query: 2068 PSSLLLSWN--PPKKANGIITQYCLYMDGR---------LIYSGSEENYTVTDLAVFTPH 2116
SS+L+ W+ P NG++ Y + + L+ S + +T L + +
Sbjct: 1214 -SSMLVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLY 1272
Query: 2117 QFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPVLTVL----DSRTIHIQWKQPRKISGI 2172
+ + A T +G + S + L + V P + +L + ++ + W+ P +GI
Sbjct: 1273 EVQVLAFTRIGDGSPSHPPILERTL--DDVPGPPMGILFPEVRTTSVRLIWQPPAAPNGI 1330
Query: 2173 LERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNK----YLIKLGACTGGGCTV 2228
+ Y + TH + + E+ QY G K YL ++ A T G
Sbjct: 1331 ILAYQI-----THRLNTTTANTATVEVLAPSARQYTATGLKPESVYLFRITAQTRKGW-- 1383
Query: 2229 SEASEALT------DEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSYGLYL---- 2278
EA+EAL D P P + S +SW + Y +
Sbjct: 1384 GEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELP 1443
Query: 2279 DGILIHNSSELSYRAYGFA-----PWSLHSFRVQACTAKGCA-LGPLVENRTL--EAPPE 2330
G +S+ +S+ A F P++ + FRV+A G + E+ T AP E
Sbjct: 1444 SGRWALHSASVSHNASSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDE 1503
Query: 2331 GTVNVFVKTQGSRKAHVRWEAPFRP--NGLLT------HSVLFTGI--FYVDPVGNNYTL 2380
+ V + +RW+ P NG+L +L+ G+ F + + N
Sbjct: 1504 APTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGINNPGAT 1563
Query: 2381 LNVTKVMYSGEETNLWVL----IDGLVPFTNYTVQVNISNSQGSLITDP-----ITIAMP 2431
MYS + L +D L Y +++++ N+ G + P + A+P
Sbjct: 1564 WAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVP 1623
Query: 2432 PGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPR----YQLQMRSGDSTHGFLELFS 2487
AP V+ + AT T L V W P ++ G + Y + + G+ T LF
Sbjct: 1624 TAAPRNVV---VHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFL 1680
Query: 2488 NPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAEDKPGPVVPPIL--LDVK 2545
A S ++ +L YT YM + A N G S P + P P + ++
Sbjct: 1681 ---AENSVKLKNLTGYTAYMVSVAAFNAAGDGPRS-TPTQGQTQQAAPSAPSSVKFSELT 1736
Query: 2546 SRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGNVTNCTVMHLHPY----------TA 2595
+ + V+W+ P+ NG++ Y + + + V P
Sbjct: 1737 TTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVT 1796
Query: 2596 YKFQVEACTSKGCSLSPESQ-TVWTLPGAPEGIPSP---ELFSDTPTSVIISWQPPTHPN 2651
Y+F++ A K + PE + V T PG EG P P + +++ I W
Sbjct: 1797 YRFRIRA---KTFTYGPEIEANVTTGPG--EGAPGPPGVPIIVRYSSAIAIHWSSGDPGK 1851
Query: 2652 GLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHG-GTN 2710
G + + IE R + L+ + L P Y++RV+ +G GT
Sbjct: 1852 GPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTP 1911
Query: 2711 SSAWVEVTTRPSRP 2724
SS V + + P
Sbjct: 1912 SSPSQSVPAQKANP 1925
Score = 84.7 bits (208), Expect = 2e-15
Identities = 134/637 (21%), Positives = 236/637 (37%), Gaps = 114/637 (17%)
Query: 3450 TIHTGSVNTYSYTDVNLKPYMTYEYRISAWN--SYGRGLSKAVRARTKEDVPQGVSPPTW 3507
T+ + + YT LKP Y +RI+A +G V K D PQ S P
Sbjct: 1349 TVEVLAPSARQYTATGLKPESVYLFRITAQTRKGWGEAAEALVVTTEKRDRPQPPSRPMV 1408
Query: 3508 TKIDNLEDTIVLNWRKPIQSNGPIIYYIL----LRNGIERFRGTSLSFSDK----EGIQP 3559
+ D +++L+W P+ YY + L +G S+S + + ++P
Sbjct: 1409 QQEDVRARSVLLSWEPGSDGLSPVRYYTIQTRELPSGRWALHSASVSHNASSFIVDRLKP 1468
Query: 3560 FQEYSYQLKACTVAGCATSSKVVAA--TTQGVP-ESILPPSITALSAVALHLSWSVP--E 3614
F Y +++KA G + S+ + T Q P E+ S+T + ++ + W P +
Sbjct: 1469 FTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAED 1528
Query: 3615 KSNGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLG 3674
K NG++ ++IR R+ GL+ FTL + G T +E
Sbjct: 1529 KINGILLGFRIRY-------------RELLYEGLR-----GFTLRGINNPGATWAE---- 1566
Query: 3675 QTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNF 3734
+ +S+ ++QY+L
Sbjct: 1567 -----------------------LTSMYSMRNLSRPSLTQYELD---------------- 1587
Query: 3735 TDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIY--------PPYNITVIGP 3786
NL + RY ++ V G + P S P+E++ P N+ V G
Sbjct: 1588 ---NLNKHRRYEIRMSVYNAVG---------EGPSSPPQEVFVGEAVPTAAPRNVVVHGA 1635
Query: 3787 YS--IFVAWIPPGILIPEIPVE-YNVLLNDGSVTPLAFSVG----HHQSTLLENLTPFTQ 3839
+ + V W PP + ++ Y + + L V S L+NLT +T
Sbjct: 1636 TATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTA 1695
Query: 3840 YEIRIQACQNGSCGV-SSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKPNGIII 3898
Y + + A G S+ +T +AAP +S L + + + W P+ PNGI+
Sbjct: 1696 YMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILE 1755
Query: 3899 NYFIYRRPAGIEE--ESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWS 3956
Y + P + ++ V +G + L Y +R+RA E +
Sbjct: 1756 GYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEAN 1815
Query: 3957 LTQTLEAPPQDFPAPWAQ---ATSAHSVLLNWTKPESPNGIISHYRVVYQERPDDPTFNS 4013
+T P + P P + ++ ++W+ + G I+ Y V + RP D
Sbjct: 1816 VT---TGPGEGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRY--VIEARPSDEGLWD 1870
Query: 4014 PTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAG 4050
+ + +S+ + L+P +Y V+A N G
Sbjct: 1871 ILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYG 1907
Score = 80.5 bits (197), Expect = 4e-14
Identities = 107/439 (24%), Positives = 184/439 (41%), Gaps = 53/439 (12%)
Query: 1114 DLLPYTKYSYYIETTNVHGSTR-SVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTL 1172
DL +T+Y ++ N GS S V +T+ VP T + S S+ + W+ +
Sbjct: 1164 DLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALATTSSSMLVRWSEV 1223
Query: 1173 --SNQSGPIEKY-ILSCAPLAGGQPCV-SYEGHET-SATIWNLVPFAKYDFSVQACT--- 1224
++++G + Y ++ + QP EG+ + SA + L + Y+ V A T
Sbjct: 1224 PEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQVLAFTRIG 1283
Query: 1225 SGGCLHS--LPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRR 1282
G H L T+ PP + P+++ +T + + W PPA NGII+ Y++ R
Sbjct: 1284 DGSPSHPPILERTLDDVPGPPMGILFPEVR---TTSVRLIWQPPAAPNGIILAYQITHRL 1340
Query: 1283 LRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAV 1342
+T T + E L P T TGL+P + Y FR+ A
Sbjct: 1341 NTTTANTATVE----------------------VLAPSARQYTATGLKPESVYLFRITAQ 1378
Query: 1343 NMAGSVSSA----WVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYD 1398
G +A +E+ P + + S+ +SWE +D ++ V Y
Sbjct: 1379 TRKGWGEAAEALVVTTEKRDRPQPPSRPMVQQEDVRARSVLLSWEPGSDGLS--PVRYYT 1436
Query: 1399 INMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGC--VTSA 1456
I + + P + + + H A S+ V+ LKP+ Y+F + N +G +
Sbjct: 1437 IQ--TRELPSGRWALHSASVSHNAS----SFIVDRLKPFTSYKFRVKATNDIGDSEFSEE 1490
Query: 1457 SGAGQTLAAAPAQLRPPL-VKGINSTTIHLKWFPPEE--LNGPSPIYQLERRESSLPALM 1513
S + TL AAP + L V +T++ ++W PP E +NG +++ RE L
Sbjct: 1491 SESLTTLQAAPDEAPTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLR 1550
Query: 1514 TTMMKGIRFIGNGYCKFPS 1532
++GI G + + S
Sbjct: 1551 GFTLRGINNPGATWAELTS 1569
Score = 60.5 bits (145), Expect = 4e-08
Identities = 101/432 (23%), Positives = 165/432 (38%), Gaps = 60/432 (13%)
Query: 2750 QNGDILSYEIHMPDPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTES 2809
++G L E H P I L S +SQ T Y+ +++ G + + S
Sbjct: 533 KDGATLGTESH---PRIRLDRNGSLHISQ--TWSGDIGTYTCRVISAGGND------SRS 581
Query: 2810 LPTYVTTHPTVPQNVGPLSVIPLSESYVV-ISWQPPSKPNGPNLRYELLRRKIQQP---- 2864
V P P++ P++ + E + ++W P N P +RY L + P
Sbjct: 582 AHLRVRQLPHAPEH--PVATLSTVERRAINLTWTKPFDGNSPLIRYILEMSENNAPWTVL 639
Query: 2865 LASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPSREVTVTTLAGL 2924
LAS P+ + KGL +Y++ L N VG + T L
Sbjct: 640 LASVDPKATS------------VTVKGLVPARSYQFRLCAVNDVG--KGQFSKDTERVSL 685
Query: 2925 PERGA-----NLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKIL--- 2976
PE N+ AS + +I ++W P G ++ Y + + A +
Sbjct: 686 PEEPPTAPPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCLAGLPVGYQFKNIT 745
Query: 2977 -PDVNSHVIGHLKPNTEYWIFISVFNGVH-SINSAGLHATTCDGEPQGMLPPEVV---II 3031
DVN+ ++ L T Y I ++ +N + S+ + T G P +PP V
Sbjct: 746 DADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPT--VPPGNVHAEAT 803
Query: 3032 NSTAVRVIWTSPSNP--NGVVTEYSIYV---NNKLYKTGMNVPGSF-------ILRDLSP 3079
NST +R W +PS NG+ Y + + T + +F + L
Sbjct: 804 NSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKK 863
Query: 3080 FTIYDIQVEVCTIYAC-VKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNG 3138
FT Y V T +S + T ED P + + I SL++ W P + NG
Sbjct: 864 FTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNG 923
Query: 3139 IILGYDLLWKTW 3150
I+ GY + W+ +
Sbjct: 924 ILTGYRISWEEY 935
Score = 56.2 bits (134), Expect = 8e-07
Identities = 99/402 (24%), Positives = 152/402 (37%), Gaps = 75/402 (18%)
Query: 1134 TRSVAVTYKTKPGVPEGNL-TLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGG 1192
+RS + + P PE + TLS + ++ LTWT + + P+ +YIL +
Sbjct: 579 SRSAHLRVRQLPHAPEHPVATLS---TVERRAINLTWTKPFDGNSPLIRYILEMS--ENN 633
Query: 1193 QP----CVSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHSLPIT--VTTAQAPPQRL 1246
P S + TS T+ LVP Y F + A G T V+ + PP
Sbjct: 634 APWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPP--T 691
Query: 1247 SPPKMQKIS---STELHVEWSPPAE------LNGIIIRYELYMRRLRSTKETTSEESRVF 1297
+PP+ S + + ++W PP E L G IIRY L
Sbjct: 692 APPQNVIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYCL------------------- 732
Query: 1298 QSSGWLSPHSF--VESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVS 1354
+G + F + A+ N L + L +T YE V A N AG V S+ V+
Sbjct: 733 --AGLPVGYQFKNITDADVNNL-------LLEDLIIWTNYEIEVAAYNSAGLGVYSSKVT 783
Query: 1355 ERTGESAPVFMIPPS---VFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSI 1411
E T + P +PP +S ++ +W P+ G GY + + E ++ +
Sbjct: 784 EWTLQGVPT--VPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKL-IAWEPEQEEEV 840
Query: 1412 PMA-----FSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSV--GCVTSASGAGQTLA 1464
M F +H V GLK + Y FT LC + S +T
Sbjct: 841 TMVTARPNFQDSIHVG-------FVSGLKKFTEY-FTSVLCFTTPGDGPRSTPQLVRTHE 892
Query: 1465 AAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLERRE 1506
P + I T++ + W P E NG Y++ E
Sbjct: 893 DVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEE 934
Score = 53.9 bits (128), Expect = 4e-06
Identities = 115/478 (24%), Positives = 181/478 (37%), Gaps = 84/478 (17%)
Query: 1059 PPRGQVQS---SSAINLSWSPPDSPNAHW--------LTYSL--LRDGFEIYTTEDQYPY 1105
PP+ + S + +I + W PP P +H + Y L L G++ D
Sbjct: 693 PPQNVIASGRTNQSIMIQWQPP--PESHQNGILKGYIIRYCLAGLPVGYQFKNITDA--- 747
Query: 1106 SIQYFLDTDLLPYTKYSYYIETTNVHG----STRSVAVTYKTKPGVPEGNLTLSYIIPIG 1161
+ L DL+ +T Y + N G S++ T + P VP GN+ +
Sbjct: 748 DVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNV---HAEATN 804
Query: 1162 SDSVTLTWTTLSNQ--SGPIEKYILSC--------APLAGGQPCVSYEGHETSATIWNLV 1211
S ++ TW S Q +G + Y L + +P +++ + L
Sbjct: 805 STTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARP--NFQDSIHVGFVSGLK 862
Query: 1212 PFAKYDFSVQACTS-GGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELN 1270
F +Y SV T+ G S P V T + P + +I T L V W P E N
Sbjct: 863 KFTEYFTSVLCFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKN 922
Query: 1271 GIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLE 1330
GI+ Y + S +E +RV P+ +E +TGL
Sbjct: 923 GILTGYRI------SWEEYNRTNTRVTH----YLPNVTLE-------------YRVTGLT 959
Query: 1331 PYTKYEFRVLAVNM--AGSVSSAWVSERTGESAPVFMIPPSVFPLSSY---SLNISWEKP 1385
T Y V A+ G VS++ +S P PP+ +S+ S+ + +
Sbjct: 960 ALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPG---PPTNLGISNIGPRSVTLQFRPG 1016
Query: 1386 ADNVTRGK--VVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFT 1443
D T +V + ++ E I ++ A+S E V L P+ Y F
Sbjct: 1017 YDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNE--PDARSME----VPDLNPFTCYSFR 1070
Query: 1444 ITLCNSVGC--VTSASGAGQTLAAAPAQLRPPLV--KGINSTTIHLKWFP-PE-ELNG 1495
+ N VG + S QTL AP + P V + + T++ L+W P PE E NG
Sbjct: 1071 MRQVNIVGTSPPSQPSRKIQTL-QAPPDMAPANVSLRTASETSLWLRWMPLPEMEYNG 1127
Score = 52.8 bits (125), Expect = 9e-06
Identities = 70/303 (23%), Positives = 113/303 (37%), Gaps = 40/303 (13%)
Query: 1251 MQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVE 1310
+ + +++ W+ P + N +IRY L M ++ W + V+
Sbjct: 600 LSTVERRAINLTWTKPFDGNSPLIRYILEMSE---------------NNAPWTVLLASVD 644
Query: 1311 SANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSV 1370
P T T+ GL P Y+FR+ AVN G + +ER PP
Sbjct: 645 --------PKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQN 696
Query: 1371 FPLS---SYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQEL 1427
S + S+ I W+ P ++ G + GY I +P+ + Q + +
Sbjct: 697 VIASGRTNQSIMIQWQPPPESHQNGILKGYIIRYC-----LAGLPVGY-QFKNITDADVN 750
Query: 1428 SYTVEGLKPYRIYEFTITLCNSVGC-VTSASGAGQTLAAAPAQLRPP---LVKGINSTTI 1483
+ +E L + YE + NS G V S+ TL P PP + NSTTI
Sbjct: 751 NLLLEDLIIWTNYEIEVAAYNSAGLGVYSSKVTEWTLQGVPTV--PPGNVHAEATNSTTI 808
Query: 1484 HLKWF--PPEELNGPSPIYQLERRESSLPALMTTMMKGIRFIGNGYCKFPSSTHPVNTDF 1541
W P+ +NG + Y+L E +T + F + + F S F
Sbjct: 809 RFTWNAPSPQFINGINQGYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYF 868
Query: 1542 TGI 1544
T +
Sbjct: 869 TSV 871
Score = 51.6 bits (122), Expect = 2e-05
Identities = 101/455 (22%), Positives = 170/455 (37%), Gaps = 80/455 (17%)
Query: 1069 AINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTD----------LLPY 1118
AINL+W+ P N+ + Y L +E+ P+++ D L+P
Sbjct: 607 AINLTWTKPFDGNSPLIRYIL-------EMSENNAPWTV-LLASVDPKATSVTVKGLVPA 658
Query: 1119 TKYSYYIETTNVHGSTRSVAVTYKTK-----PGVPEGNLTLSYIIPIGSDSVTLTW--TT 1171
Y + + N G + T + P P N+ S + S+ + W
Sbjct: 659 RSYQFRLCAVNDVGKGQFSKDTERVSLPEEPPTAPPQNVIAS---GRTNQSIMIQWQPPP 715
Query: 1172 LSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWN-----LVPFAKYDFSVQACTSG 1226
S+Q+G ++ YI+ G P + T A + N L+ + Y+ V A S
Sbjct: 716 ESHQNGILKGYIIRYC--LAGLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSA 773
Query: 1227 GC-LHSLPITVTTAQAPPQRLSPP---KMQKISSTELHVEWSPPAE--LNGIIIRYELYM 1280
G ++S +T T Q P PP + +ST + W+ P+ +NGI Y+L
Sbjct: 774 GLGVYSSKVTEWTLQGVP--TVPPGNVHAEATNSTTIRFTWNAPSPQFINGINQGYKLIA 831
Query: 1281 RRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVL 1340
+E T +R +F +S + + ++GL+ +T+Y VL
Sbjct: 832 WEPEQEEEVTMVTAR----------PNFQDSIH---------VGFVSGLKKFTEYFTSVL 872
Query: 1341 AVNMAG-SVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKVVGYDI 1399
G S RT E P + S + SL +SW++P + G + GY I
Sbjct: 873 CFTTPGDGPRSTPQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEK--NGILTGYRI 930
Query: 1400 NMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNS-----VGCVT 1454
+ + +++ H + L Y V GL Y + S V T
Sbjct: 931 SW-------EEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSAST 983
Query: 1455 SASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFP 1489
+SG L P L + I ++ L++ P
Sbjct: 984 ISSGVPPELPGPPTNLG---ISNIGPRSVTLQFRP 1015
Score = 40.4 bits (93), Expect = 0.046
Identities = 71/347 (20%), Positives = 131/347 (37%), Gaps = 52/347 (14%)
Query: 3465 NLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRKP 3524
NL + YE R+S +N+ G G S + + +P + + W P
Sbjct: 1588 NLNKHRRYEIRMSVYNAVGEGPSSPPQEVFVGEAVPTAAPRNVVVHGATATQLDVTWEPP 1647
Query: 3525 --IQSNGPI----IYYILLRNGIERFRGTSLSFSDK----EGIQPFQEYSYQLKACTVAG 3574
NG I IY+ + G R +L ++ + + + Y + A AG
Sbjct: 1648 PLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENSVKLKNLTGYTAYMVSVAAFNAAG 1707
Query: 3575 CA-TSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKSNGVIKEYQI----RQVG 3629
S+ T Q P + + L+ ++++SW P+ NG+++ Y++
Sbjct: 1708 DGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPV 1767
Query: 3630 KGLIHTDTTDRRQHT-----VTGLQPYTNYSFTLTACT-------SAGCTSSEPFLGQTL 3677
G+ T D + ++ V L Y F + A T A T+ P G
Sbjct: 1768 DGVSKIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPEIEANVTTG-PGEG--- 1823
Query: 3678 QAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTD- 3736
P GV + R+ S+ + ++WS + G +++Y + ++ D
Sbjct: 1824 APGPPGVPIIVRY----SSAIAIHWSSGDPGKGPITRYVIEAR--------PSDEGLWDI 1871
Query: 3737 --KNLEPN-SRYTYKLEVKTGGGS-----SASDDYIVQTPMSTPEEI 3775
K++ S YT+ +++ G S A +DY TP S + +
Sbjct: 1872 LIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSV 1918
Score = 36.6 bits (83), Expect = 0.67
Identities = 43/177 (24%), Positives = 68/177 (38%), Gaps = 20/177 (11%)
Query: 1066 SSSAINLSWSPPDSPNAHWLTYSLLR------DGFEIYTTEDQYPYSIQYFLDTDLLPYT 1119
+++++N+SW P PN Y L+ DG T D S + DL
Sbjct: 1736 TTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWLKVKDLAEGV 1795
Query: 1120 KYSYYIET-TNVHGSTRSVAVTY---KTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQ 1175
Y + I T +G VT + PG P + + Y S ++ + W++
Sbjct: 1796 TYRFRIRAKTFTYGPEIEANVTTGPGEGAPGPPGVPIIVRY-----SSAIAIHWSSGDPG 1850
Query: 1176 SGPIEKYILSCAPLAGG--QPCVSYEGHETSATIWN---LVPFAKYDFSVQACTSGG 1227
GPI +Y++ P G + E S+ ++ L P YDF V A G
Sbjct: 1851 KGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYG 1907
>gi|93204871 netrin 4 [Homo sapiens]
Length = 628
Score = 197 bits (500), Expect = 3e-49
Identities = 131/429 (30%), Positives = 203/429 (47%), Gaps = 56/429 (13%)
Query: 371 ISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNCGA-FGMKNNGD 429
I +DLE ++ ++I+ F SP+P + + R ++ W+ ++YFA NC A FG+++ D
Sbjct: 117 IQLDLE-AEFYFTHLIVMFKSPRPAAMVLDRSQDFGKTWKPYKYFATNCSATFGLED--D 173
Query: 430 LEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQIRFHF 489
+ K ++ + S+ P + G V F L+P + Y+ +QE +K T +R
Sbjct: 174 VVKKGAICTSKYSSPFPCTGGEVIFKALSPPYDTENPYS-----AKVQEQLKITNLRVQL 228
Query: 490 HGQYYTTETAVNLRHR-----YYAVDEITISGRCQCHGHADNCDTTS--QPYR------- 535
+ +L +YA+ + + G C C+GHAD C +P +
Sbjct: 229 LKRQSCPCQRNDLNEEPQHFTHYAIYDFIVKGSCFCNGHADQCIPVHGFRPVKAPGTFHM 288
Query: 536 ----CLCSQESFTEGLHCDRCLPLYNDKPFRQGD-QVYAFN-CKPCQCNSHSKSCHYNIS 589
C+C T G HC C PLYND+P+ D + A N C+ C+CN H+ +CH++++
Sbjct: 289 VHGKCMCKHN--TAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTCHFDVN 346
Query: 590 VDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGT- 648
V GGVCDDC+HNT G+ C+ CK F+R + SA D CKPC C VG+
Sbjct: 347 VWEASGNR---SGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGSA 403
Query: 649 ---RNGSILCDQIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGD 705
N CD G C CK V+GR+C++C G++ + GC PC+C S
Sbjct: 404 VLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDY---GCRPCDCAGS------ 454
Query: 706 ITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQ 765
C +G C I + +F +S EP + HSG+
Sbjct: 455 --CDPITGDCISSHTDIDWYHEVPDFRPVHNKS------EPA-WEWEDAQGFSALLHSGK 505
Query: 766 CECKKEAKG 774
CECK++ G
Sbjct: 506 CECKEQTLG 514
Score = 87.0 bits (214), Expect = 4e-16
Identities = 60/188 (31%), Positives = 80/188 (42%), Gaps = 42/188 (22%)
Query: 658 IGGQCNCKRHVSGRQCNQCQNGFYNLQELD--------PDGCSPCNCNTSGTVDGDITCH 709
+ G+C CK + +G C C YN + + P+ C C CN G D TCH
Sbjct: 289 VHGKCMCKHNTAGSHCQHCAP-LYNDRPWEAADGKTGAPNECRTCKCN--GHAD---TCH 342
Query: 710 -----------QNSGQCK-CKANVIGLRCDHCNFGF--KFLRSFNDV-GCEPCQCNLHGS 754
++ G C C+ N G C C GF R F+ C+PC C+ GS
Sbjct: 343 FDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPVGS 402
Query: 755 VN------KFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVC 808
FC+P +G C CK G +CD C ++G C+ CDC AGS C
Sbjct: 403 AVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYWGFGDYGCRPCDC--AGS-----C 455
Query: 809 NAKTGQCI 816
+ TG CI
Sbjct: 456 DPITGDCI 463
Score = 85.1 bits (209), Expect = 2e-15
Identities = 68/223 (30%), Positives = 90/223 (40%), Gaps = 52/223 (23%)
Query: 707 TCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQC 766
T H G+C CK N G C HC +ND E G+ N+ C C
Sbjct: 285 TFHMVHGKCMCKHNTAGSHCQHC------APLYNDRPWEAADGKT-GAPNE-CRT----C 332
Query: 767 ECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQC 826
+C A DTC DV +A +G+ G VC+ C+ N EG+ C
Sbjct: 333 KCNGHA-----DTCH-----FDVNVWEA-----SGNRSGGVCDD------CQHNTEGQYC 371
Query: 827 NKCLEGNFYLRQNNSF----LCLPCNCDKTGTI----NGSLLCNKSTGQCPCKLGVTGLR 878
+C G FY F C PC+C G+ N C+ S G CPCK GV G R
Sbjct: 372 QRCKPG-FYRDLRRPFSAPDACKPCSCHPVGSAVLPANSVTFCDPSNGDCPCKPGVAGRR 430
Query: 879 CNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCL 921
C++C + C+ C+C CDPI+G C+
Sbjct: 431 CDRCMVGYWGF---GDYGCRPCDC-------AGSCDPITGDCI 463
Score = 77.4 bits (189), Expect = 3e-13
Identities = 72/258 (27%), Positives = 101/258 (39%), Gaps = 46/258 (17%)
Query: 804 PGTVCNAKTGQCICKPNVEGRQCNKC--LEGNFYLRQNNSFLCLPCNCDKTGTINGSL-L 860
PGT + G+C+CK N G C C L + + P C +T NG
Sbjct: 283 PGTF-HMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNEC-RTCKCNGHADT 340
Query: 861 C-----------NKSTGQCP-CKLGVTGLRCNQCEPHRYNLTIDNFQH---CQMCECDSL 905
C N+S G C C+ G C +C+P Y F C+ C C +
Sbjct: 341 CHFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDACKPCSCHPV 400
Query: 906 GT--LPG---TICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVN 960
G+ LP T CDP +G C C P GRRC++C G++ GC PC C +
Sbjct: 401 GSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCMVGYW--GFGDYGCRPCDCAGS---- 454
Query: 961 HICNSLTGQCVCQDASIAGQRCDQCKDHYF---GFDPQTGRCQPCNCHLSGALNETCHLV 1017
C+ +TG C+ I D Y F P + +P A + L
Sbjct: 455 --CDPITGDCISSHTDI---------DWYHEVPDFRPVHNKSEPA-WEWEDAQGFSALLH 502
Query: 1018 TGQCFCKQFVTGSKCDAC 1035
+G+C CK+ G+ C
Sbjct: 503 SGKCECKEQTLGNAKAFC 520
Score = 59.3 bits (142), Expect = 1e-07
Identities = 45/155 (29%), Positives = 60/155 (38%), Gaps = 29/155 (18%)
Query: 909 PGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNA----TG----CLPCSCHTTGAVN 960
PGT + G+C+C N G C C P + P A TG C C C+
Sbjct: 283 PGTF-HMVHGKCMCKHNTAGSHCQHCAPLYNDRPWEAADGKTGAPNECRTCKCNGHADTC 341
Query: 961 HI--------CNSLTGQCVCQDASIAGQRCDQCKDHYF-----GFDPQTGRCQPCNCHLS 1007
H N G C + GQ C +CK ++ F C+PC+CH
Sbjct: 342 HFDVNVWEASGNRSGGVCDDCQHNTEGQYCQRCKPGFYRDLRRPFSAPDA-CKPCSCHPV 400
Query: 1008 GALNETCHLVT------GQCFCKQFVTGSKCDACV 1036
G+ + VT G C CK V G +CD C+
Sbjct: 401 GSAVLPANSVTFCDPSNGDCPCKPGVAGRRCDRCM 435
Score = 33.1 bits (74), Expect = 7.4
Identities = 12/25 (48%), Positives = 14/25 (56%)
Query: 1013 TCHLVTGQCFCKQFVTGSKCDACVP 1037
T H+V G+C CK GS C C P
Sbjct: 285 TFHMVHGKCMCKHNTAGSHCQHCAP 309
>gi|148613884 netrin 1 [Homo sapiens]
Length = 604
Score = 196 bits (497), Expect = 7e-49
Identities = 116/380 (30%), Positives = 186/380 (48%), Gaps = 30/380 (7%)
Query: 317 RYCIPNDAGDTADNRVSRLNP----EAHPLSFVNDNDVG---TSWVSNVFTNITQLNQGV 369
RYC+ ++ G+ N +AHP +F+ D + T W S N Q V
Sbjct: 76 RYCVVSERGEERLRSCHLCNASDPKKAHPPAFLTDLNNPHNLTCWQSE---NYLQFPHNV 132
Query: 370 TISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNCGA-FGMKNNG 428
T+++ L +++V Y+ +QF SP+P + I + + W +Q+++ C + +
Sbjct: 133 TLTLSLGK-KFEVTYVSLQFCSPRPESMAIYKSMDYGRTWVPFQFYSTQCRKMYNRPHRA 191
Query: 429 DLEKPDSVNCLQLSNFT---PYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQI 485
+ K + + + T P S G + FS L + RP ++F N+P LQ++V AT I
Sbjct: 192 PITKQNEQEAVCTDSHTDMRPLSGGLIAFSTL----DGRPSAHDFDNSPVLQDWVTATDI 247
Query: 486 R-----FHFHGQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQ 540
R H G ++ + +YAV ++ + GRC+C+GHA C + +C
Sbjct: 248 RVAFSRLHTFGDENEDDSELARDSYFYAVSDLQVGGRCKCNGHAARC-VRDRDDSLVCDC 306
Query: 541 ESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRG 600
T G CDRC P + D+P+++ A C C CN H++ C +N+ + R
Sbjct: 307 RHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSG---RK 363
Query: 601 GGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG 660
GGVC +C HNT GR+C CK+ ++R +G + CK CDC VG + C+Q G
Sbjct: 364 SGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKT--CNQTTG 421
Query: 661 QCNCKRHVSGRQCNQCQNGF 680
QC CK V+G CN+C G+
Sbjct: 422 QCPCKDGVTGITCNRCAKGY 441
Score = 84.7 bits (208), Expect = 2e-15
Identities = 56/174 (32%), Positives = 73/174 (41%), Gaps = 27/174 (15%)
Query: 680 FYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSF 739
FY + +L G CN + + V +S C C+ N G CD C F + R +
Sbjct: 273 FYAVSDLQVGGRCKCNGHAARCVRD----RDDSLVCDCRHNTAGPECDRCK-PFHYDRPW 327
Query: 740 NDVG------CEPCQCNLHGSVNKFC--------NPHSGQC-ECKKEAKGLQCDTCRENF 784
C C CNLH +F G C C+ G C C+E +
Sbjct: 328 QRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHNTAGRHCHYCKEGY 387
Query: 785 Y---GLDVTN---CKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEG 832
Y G +T+ CKACDC G+ G CN TGQC CK V G CN+C +G
Sbjct: 388 YRDMGKPITHRKACKACDCHPVGAA-GKTCNQTTGQCPCKDGVTGITCNRCAKG 440
Score = 80.9 bits (198), Expect = 3e-14
Identities = 50/163 (30%), Positives = 69/163 (42%), Gaps = 37/163 (22%)
Query: 747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFY--------GLDVTNCKACDCD 798
C+CN H + S C+C+ G +CD C+ Y + C AC+C+
Sbjct: 285 CKCNGHAARCVRDRDDSLVCDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCN 344
Query: 799 T--------------AGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFL- 843
+G G VC C+ N GR C+ C EG Y R +
Sbjct: 345 LHARRCRFNMELYKLSGRKSGGVC------LNCRHNTAGRHCHYCKEG--YYRDMGKPIT 396
Query: 844 ----CLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQC 882
C C+C G + CN++TGQCPCK GVTG+ CN+C
Sbjct: 397 HRKACKACDCHPVGAAGKT--CNQTTGQCPCKDGVTGITCNRC 437
Score = 73.6 bits (179), Expect = 5e-12
Identities = 49/192 (25%), Positives = 83/192 (43%), Gaps = 41/192 (21%)
Query: 618 ELCKDYFFRQVGADPSAIDVCKPCDCD-----TVGTRNGSILCDQIGGQCNCKRHVSGRQ 672
EL +D +F V S + V C C+ V R+ S++CD C+ + +G +
Sbjct: 266 ELARDSYFYAV----SDLQVGGRCKCNGHAARCVRDRDDSLVCD-------CRHNTAGPE 314
Query: 673 CNQCQNGFYN-----LQELDPDGCSPCNCNTSGTVDG------DITCHQNSGQC-KCKAN 720
C++C+ Y+ + + C CNCN ++ ++ G C C+ N
Sbjct: 315 CDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRKSGGVCLNCRHN 374
Query: 721 VIGLRCDHCNFGFKFLRSFNDVG--------CEPCQCNLHGSVNKFCNPHSGQCECKKEA 772
G C +C G+ + D+G C+ C C+ G+ K CN +GQC CK
Sbjct: 375 TAGRHCHYCKEGY-----YRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQCPCKDGV 429
Query: 773 KGLQCDTCRENF 784
G+ C+ C + +
Sbjct: 430 TGITCNRCAKGY 441
Score = 73.2 bits (178), Expect = 6e-12
Identities = 49/157 (31%), Positives = 69/157 (43%), Gaps = 19/157 (12%)
Query: 920 CLCVPNRQGRRCNQCQPGFYISPGN------ATGCLPCSCHTTGA---VNHICNSLTGQ- 969
C C N G C++C+P Y P A C+ C+C+ N L+G+
Sbjct: 304 CDCRHNTAGPECDRCKPFHYDRPWQRATAREANECVACNCNLHARRCRFNMELYKLSGRK 363
Query: 970 ----CVCQDASIAGQRCDQCKDHYFGF--DPQTGR--CQPCNCHLSGALNETCHLVTGQC 1021
C+ + AG+ C CK+ Y+ P T R C+ C+CH GA +TC+ TGQC
Sbjct: 364 SGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAAGKTCNQTTGQC 423
Query: 1022 FCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQP 1058
CK VTG C+ C + + C K P P
Sbjct: 424 PCKDGVTGITCNRCAKGYQQ-SRSPIAPCIKIPVAPP 459
Score = 60.1 bits (144), Expect = 6e-08
Identities = 44/163 (26%), Positives = 68/163 (41%), Gaps = 22/163 (13%)
Query: 815 CICKPNVEGRQCNKCLEGNF-------YLRQNNSFLCLPCNCD------KTGTINGSLLC 861
C C+ N G +C++C ++ R+ N C+ CNC+ + L
Sbjct: 304 CDCRHNTAGPECDRCKPFHYDRPWQRATAREANE--CVACNCNLHARRCRFNMELYKLSG 361
Query: 862 NKSTGQC-PCKLGVTGLRCNQCEPHRYN---LTIDNFQHCQMCECDSLGTLPGTICDPIS 917
KS G C C+ G C+ C+ Y I + + C+ C+C +G G C+ +
Sbjct: 362 RKSGGVCLNCRHNTAGRHCHYCKEGYYRDMGKPITHRKACKACDCHPVGAA-GKTCNQTT 420
Query: 918 GQCLCVPNRQGRRCNQCQPGFYISPGNATGC--LPCSCHTTGA 958
GQC C G CN+C G+ S C +P + TT A
Sbjct: 421 GQCPCKDGVTGITCNRCAKGYQQSRSPIAPCIKIPVAPPTTAA 463
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 194 bits (492), Expect = 3e-48
Identities = 339/1520 (22%), Positives = 604/1520 (39%), Gaps = 203/1520 (13%)
Query: 3690 HIIINSTTVELYWSLPEKPNGLVSQYQLSRNGNLLFLGGSEEQNFTDKNLEPNSRYT--- 3746
H++I TT L+ P VS + + N+ S + +K+ T
Sbjct: 583 HVVIKGTTATLHCGATHDPR--VSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSG 640
Query: 3747 ----YKLEVKTGGGSSA--SDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWIPPGILI 3800
Y E+ + GG+ + + +++ P S + P + +++ ++W+ P
Sbjct: 641 DIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSH---SHAVVLSWVRP--FD 695
Query: 3801 PEIPVEYNVLLNDGSVTPLAF---SVGHHQSTL-LENLTPFTQYEIRIQACQNGSCG--- 3853
P+ Y ++ + +P +VG + + + LTP Y+ R+ A G
Sbjct: 696 GNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYS 755
Query: 3854 --VSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPPEKP--NGIIINYFIYRRPAGI 3909
S M + P +AP + V + I ++W PP + NG++ Y + R AG+
Sbjct: 756 AETSRLMLPEEPPSAPP--KNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGL 813
Query: 3910 EEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQ-TLE----AP 3964
E + + + D + +T YE +V A N G ++T+ TL+ AP
Sbjct: 814 PGEYQQRNITSPEVNYCLVTDLII-WTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAP 872
Query: 3965 PQDFPAPWAQATSAHSVLLNWTKPESP--NGIISHYRVVYQERPDDPTFNSPTVHAFTVK 4022
PQ+ +A ++ ++ W P NGI Y+++ D P + A
Sbjct: 873 PQNVQT---EAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPA-DAPEAVTVVTIAPDFH 928
Query: 4023 GTSHQAHLYGLEPFTTYRIGVVAANHAGE-ILSPWTLIQTLESSPSGLRNFIVEQKENGR 4081
G H H+ L+ FT Y V+ G+ S L+ T E P + + + +
Sbjct: 929 GV-HHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILD-T 986
Query: 4082 ALLLQWSEPMRTNGVIKTYNIF------SDGFLEYS--GLNRQFLFRRLDPFTLYTLTLE 4133
+L + W EP+ NG+I Y I +D L ++ ++ + L T YT+ +
Sbjct: 987 SLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVA 1046
Query: 4134 ACTRAGCAHSAPQPLWTDEAPPDSQLAPT---VHSVKSTSVELSWSEPVNPNGKIIRYEV 4190
A T G + + PPD AP+ + ++ S L + + I R+ V
Sbjct: 1047 AVTAVGTGLVTSSTI-SSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIV 1105
Query: 4191 IRRCFEGK--AWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGH 4248
EG+ A G++ +E + E E + M L P+T +++ N G
Sbjct: 1106 -----EGQVGAIGDE----EEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGP 1156
Query: 4249 T--CSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISWIP--PEQSNGIIQS--YRLQ- 4301
+ S V++TLQAPP+ ++P ++ + + L + W+P Q NG +S YR++
Sbjct: 1157 SPYSPSSRVIQTLQAPPD-VAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKY 1215
Query: 4302 -----RNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCSTSKP-----TSITT 4351
++ + D + +T EEL + Y +QA + G T +
Sbjct: 1216 WRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESV 1275
Query: 4352 LEAAPSEVSPPDLWAVSATQMNVCWS--PPTVQNGKITKYLVRYDNKES---------LA 4400
AAP VS AVS+TQ+ + W+ P QNG I Y + + K+
Sbjct: 1276 PSAAPENVSAE---AVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRG 1332
Query: 4401 GQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEALPENMDSPTLQVTGSE-- 4458
L++ L+ + Y ++A T G V + +E ++ P +++ E
Sbjct: 1333 NHTQSALLAGLRKFVLYELQVLAFTRIG--NGVPSTPLILERTKDDAPGPPVRLVFPEVR 1390
Query: 4459 --SIEITWKPPRNPNGQIRSYE----LRRDGTIVYTGLET--RYRDFTLT---PGVEYSY 4507
S+ I W+PP PNG I Y+ L +T +E R FT T P Y +
Sbjct: 1391 LTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIF 1450
Query: 4508 TVTASNSQGGILSPL------VKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGD 4561
++A QG PL + R P+ P + P+ + + + + W P
Sbjct: 1451 RLSAKTRQGWG-EPLEATVITTEKRERPAPPRELLVPQAEVTA-RSLRLQWVPGSDGASP 1508
Query: 4562 IINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCASSD 4621
I +T+ +REL E + + +H + + +V++L+PF Y++R++A +G SD
Sbjct: 1509 IRYFTMQVRELPRGEWQTYSSSISHEA---TACVVDRLRPFTSYKLRLKATNDIG--DSD 1563
Query: 4622 WTFIQTPEIAPLMQPP--PHLEVQMAPGGFQPTVSLLWTGPLQP--NGKVLYYELYRRQI 4677
++ +T + L P P V P +V + W P NG + Y +Y R++
Sbjct: 1564 FSS-ETEAVTTLQDVPGEPPGSVSATPHTTS-SVLIQWQPPRDESLNGLLQGYRIYYREL 1621
Query: 4678 ATQPRKS-------NPVLIY------------NGSSTSFID--SELLPFTEYEYQVWAVN 4716
+ NP+ ++ N SSTS + + L + YE + A N
Sbjct: 1622 EYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYN 1681
Query: 4717 SAGKAPSSW-TWCRTGPAPPEGLRAPTFHVISSTQAVVNIS----APGKPNGIVSLYRLF 4771
G++P+S G A P + V T + + ++ P NG + Y+++
Sbjct: 1682 IIGESPASAPVEVFVGEAAP-AMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIY 1740
Query: 4772 SSSAHGA-ETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAEL---RTHPA 4827
A ET + + + + L+ T+++ + + + FN GP ++ RTH A
Sbjct: 1741 YWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQA 1800
Query: 4828 PPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTPSQIETKY 4887
P S + S T + W P NG++ Y + + P ++ +
Sbjct: 1801 APGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNW 1860
Query: 4888 TGLGQKASLGGLQPYTTYKLRVVAHN-EVGSTASEWISFTTQKELPQYRAPFSVDSNLSV 4946
+ + L TY RV A G I+ + P V + S
Sbjct: 1861 Q---RWLKVRDLTKGVTYFFRVQARTITYGPELQANITAGPAEGSPGSPRDVLVTKSASE 1917
Query: 4947 VCVNWSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLY--IPRTA-------DK-----TFF 4992
+ + W++ + YV+ R GL IPR+A DK T+
Sbjct: 1918 LTLQWTEGHSGDTPTTGYVIE--ARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYE 1975
Query: 4993 FQVICTTDEGSVKTPLIQYDTSTGLGLVLTTPGKKKGSRSKSTEFYSELWFIVLMAMLGL 5052
F+V+ + G + + ST + + P FY E WF+++MA+ L
Sbjct: 1976 FRVVAVNEAGYGEPS----NPSTAVSAQVEAP------------FYEEWWFLLVMALSSL 2019
Query: 5053 I-LLAIFLSLIL--QRKIHK 5069
I +L + +L+L Q K +K
Sbjct: 2020 IVILLVVFALVLHGQNKKYK 2039
Score = 182 bits (461), Expect = 1e-44
Identities = 282/1190 (23%), Positives = 477/1190 (40%), Gaps = 131/1190 (11%)
Query: 1965 SLNGYSIEVTWDEPVV-RGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGI-LTGL 2022
S + +++ ++W P I YI++ +S + + E +TG+ ++GL
Sbjct: 680 SSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPE------MTGVTVSGL 733
Query: 2023 LPFKNYAVTLTACTLAGCTE-SSHALNISTPQEAPQEVQPPVAKS--LPSSLLLSWNPPK 2079
P + Y + A G + S+ + P+E P + S S+++ W PP
Sbjct: 734 TPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPP 793
Query: 2080 KA--NGIITQYCL----------YMDGRLIYSGSEENYT-VTDLAVFTPHQFLLSACTHV 2126
+ NG++ Y L Y + + E NY VTDL ++T ++ ++A
Sbjct: 794 ETEHNGVLRGYILRYRLAGLPGEYQQRNI--TSPEVNYCLVTDLIIWTQYEIQVAAYNGA 851
Query: 2127 GC-TNSSWVLLYTAQ----LPPEHVDSPVLTVLDSRTIHIQWKQPRK--ISGILERYVL- 2178
G S V YT Q PP++V + + +S TI W P + I+GI + Y L
Sbjct: 852 GLGVFSRAVTEYTLQGVPTAPPQNVQTEAV---NSTTIQFLWNPPPQQFINGINQGYKLL 908
Query: 2179 -YMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTD 2237
+ ++ T+ ++ + + H+ + L T G S T
Sbjct: 909 AWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQ 968
Query: 2238 EDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSYGLYL------DGILIH--NSSEL 2289
ED P V S VSW EP NG+IT Y + D L H NS+
Sbjct: 969 EDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTH 1028
Query: 2290 SYRAYGFAPWSLHSFRVQACTAKGCALGPLVENRTLEA--PPE---GTVNVFVKTQGSRK 2344
Y+ G + + ++ V A TA G LV + T+ + PP+ N+ + R
Sbjct: 1029 EYKIQGLSSLTTYTIDVAAVTAVGTG---LVTSSTISSGVPPDLPGAPSNLVISNISPRS 1085
Query: 2345 AHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVP 2404
A +++ + ++ ++ V +G+ VT E + I L P
Sbjct: 1086 ATLQFRPGYDGKTSISRWIVEG---QVGAIGDEEEW--VTLYEEENEPDAQMLEIPNLTP 1140
Query: 2405 FTNYTVQVNISNSQGSLITDPIT-IAMPPGAPDGVLPPRLS--SATPTSLQVVW---STP 2458
+T+Y ++ N G P + + AP V P ++ +A+ TSL++ W
Sbjct: 1141 YTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDS 1200
Query: 2459 ARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGS 2518
N P S Y+++ D + + + + +L+ + EY ++ A N G+
Sbjct: 1201 QYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGA 1260
Query: 2519 A-HSSWIPFMTAEDKPGPVVPPILLD-VKSRMMLVTWQH--PRKSNGVITHYNIYLHGRL 2574
S + T E P + + V S +L+TW + NG+I Y I +
Sbjct: 1261 GPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKD 1320
Query: 2575 YLRTP------GNVTNCTVM-HLHPYTAYKFQVEACTSKGCSLSPE----SQTVWTLPGA 2623
P GN T ++ L + Y+ QV A T G + +T PG
Sbjct: 1321 LDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGP 1380
Query: 2624 PEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRF 2683
P + PE+ TSV I WQPP PNG++ + I R+ T T+ ++R
Sbjct: 1381 PVRLVFPEV---RLTSVRIVWQPPEEPNGIILGYQIAYRL-ASSSPHTFTTVEVGATVRQ 1436
Query: 2684 IDKTSALSPWTKYEYRVLMSTLHG-GTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDA--V 2740
T L+P + Y +R+ T G G A V T + RPA + +V E A +
Sbjct: 1437 FTATD-LAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSL 1495
Query: 2741 QVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQKVT-----HLIPFTNYSVTIVA 2795
++ W P I + + + + S+ +S + T L PFT+Y + + A
Sbjct: 1496 RLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKA 1555
Query: 2796 CSG-GNGYLGGCTESLPTYVTTHPTVP-QNVGPLSVIPLSESYVVISWQPP--SKPNGPN 2851
+ G+ TE+ VTT VP + G +S P + S V+I WQPP NG
Sbjct: 1556 TNDIGDSDFSSETEA----VTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLL 1611
Query: 2852 LRYELLRRKIQQPLAS--------NP---PEDLNRWHNI----YSGTQWLYEDKGLSRFT 2896
Y + R+++ S NP +L + S T + E L ++
Sbjct: 1612 QGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYR 1671
Query: 2897 TYEYMLFVHNSVGFTP-SREVTVTTLAGLPERG-ANLTASVLNHTAIDVRWAKPTVQDLQ 2954
YE ++ +N +G +P S V V P N+ + L + ++V W P +
Sbjct: 1672 RYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQN 1731
Query: 2955 GEVEYYTL-FWSSATSNDSLKI----LPDVNSHVIGHLKPNTEYWIFISVFN----GVHS 3005
G ++ Y + +W + + N++ K+ LP+ + +L +T+Y + IS FN G S
Sbjct: 1732 GNIQGYKIYYWEADSQNETEKMKVLFLPEPVVR-LKNLTSHTKYLVSISAFNAAGDGPKS 1790
Query: 3006 INSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVVTEYSI 3055
G G P + E I ST + V W P+ NG++ Y +
Sbjct: 1791 DPQQGRTHQAAPGAPSFLAFSE---ITSTTLNVSWGEPAAANGILQGYRV 1837
Score = 168 bits (425), Expect = 1e-40
Identities = 339/1440 (23%), Positives = 542/1440 (37%), Gaps = 202/1440 (14%)
Query: 3677 LQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQY--QLSRNGNL----LFLGGSE 3730
L +P+ + V+P +S V L W P N + Y +LS N + L G E
Sbjct: 667 LPHSPQNLLVSPNSS--HSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPE 724
Query: 3731 EQNFTDKNLEPNSRYTYKLEV--KTGGGSSASDDYIVQTPMSTPEEIYPPYNITVIGP-- 3786
T L P Y +++ + G G +++ + P P PP NI G
Sbjct: 725 MTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSA--PPKNIVASGRTN 782
Query: 3787 YSIFVAWIPPGILIPEIPVEYNVLLNDGSVT-PLAFSVGHHQST----------LLENLT 3835
SI V W PP PE E+N +L + LA G +Q L+ +L
Sbjct: 783 QSIMVQWQPP----PE--TEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLI 836
Query: 3836 PFTQYEIRIQACQNGSCGVSSRMFVK-----TPEAAPMDLNSPVLKALGSACIEIKWMPP 3890
+TQYEI++ A GV SR + P A P ++ + +A+ S I+ W PP
Sbjct: 837 IWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQT---EAVNSTTIQFLWNPP 893
Query: 3891 EKP--NGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGD--TLRPFTLYEYRVRACN 3946
+ NGI Y + PA E +V V + G L+ FT Y V
Sbjct: 894 PQQFINGINQGYKLLAWPADAPE-AVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFT 952
Query: 3947 SKGS-VESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQER 4005
+ G S L T E P S+ ++W +P NGII+ Y++ ++
Sbjct: 953 TPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVY 1012
Query: 4006 PDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTLIQT---- 4061
+ +S H T+ T+H+ + GL TTY I V A G L + I +
Sbjct: 1013 GRN---DSRLTH--TLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPP 1067
Query: 4062 -LESSPSGLRNFIVEQKE---------NGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYS 4111
L +PS L + + +G+ + +W + G I + + E +
Sbjct: 1068 DLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQV-GAIGDEEEWVTLYEEEN 1126
Query: 4112 GLNRQFL-FRRLDPFTLYTLTLEACTRAGCAHSAPQP--LWTDEAPPD-SQLAPTVHSVK 4167
+ Q L L P+T Y ++ G + +P + T +APPD + + TV +
Sbjct: 1127 EPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTAS 1186
Query: 4168 STSVELSW----SEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTF 4223
TS+ L W N N + + Y + K W + +Q+ ER
Sbjct: 1187 ETSLRLRWVPLPDSQYNGNPESVGYRI-------KYWRSD-LQSSAVAQVVSDRLERE-- 1236
Query: 4224 MYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVV---RTLQAPPEGLSPPVISYVSMNPQK 4280
+ L+ W + E ++ +N+ G W+ V RT ++ P +P +S +++ +
Sbjct: 1237 -FTIEELEEWMEYELQMQAFNAVG--AGPWSEVVRGRTRESVPSA-APENVSAEAVSSTQ 1292
Query: 4281 LLISW--IPPEQSNGIIQSYRLQRNEMLYPFSFDP------VTFNYTDEELLP----FST 4328
+L++W +P + NG+I Y++ + DP V N+T LL F
Sbjct: 1293 ILLTWTSVPEQDQNGLILGYKI----LFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVL 1348
Query: 4329 YSYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDLWAV----SATQMNVCWSPPTVQNG 4384
Y + A T G P++ LE + P + V T + + W PP NG
Sbjct: 1349 YELQVLAFTRIG--NGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNG 1406
Query: 4385 KITKYLVRYDNKESLAGQGLCLLV---------SHLQPYSQYNFSLVACTNGGCTASVSK 4435
I Y + Y S + V + L P S Y F L A T G +
Sbjct: 1407 IILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEA 1466
Query: 4436 SAWTME-----ALPENMDSPTLQVTGSESIEITWKPPRNPNGQIRSY-----ELRRDGTI 4485
+ T E A P + P +VT + S+ + W P + IR + EL R
Sbjct: 1467 TVITTEKRERPAPPRELLVPQAEVT-ARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQ 1525
Query: 4486 VYTGLETRYRDFT----LTPGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQ 4541
Y+ + L P Y + A+N G + + EPP
Sbjct: 1526 TYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSV 1585
Query: 4542 ARGPQ---EILVNWDPP--VRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIV 4596
+ P +L+ W PP NG + Y ++ REL T N + + +
Sbjct: 1586 SATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELT 1645
Query: 4597 NQ-------------------LKPFHRYEIRIQACTTLG-CASSDWTFIQTPEIAPLMQP 4636
Q LK + RYE+ + A +G +S + E AP M P
Sbjct: 1646 AQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAP 1705
Query: 4637 PPHLEVQMAP-GGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSST 4695
VQ+ P Q V+ P NG + Y++Y + +Q +++
Sbjct: 1706 Q---NVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPV 1762
Query: 4696 SFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWC-RTGPAPPEGLRAPTFHVISSTQAVVN 4754
+ + L T+Y + A N+AG P S RT A P F I+ST V+
Sbjct: 1763 VRLKN-LTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVS 1821
Query: 4755 ISAPGKPNGIVSLYRLFS---SSAHGAETVLS-EGMATQQT---LHGLQAFTNYSIGVEA 4807
P NGI+ YR+ + G V++ E Q + L Y V+A
Sbjct: 1822 WGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQA 1881
Query: 4808 CTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTAS---FRWSPPMFPNGVIHSYEL 4864
T + GP + P G L +++AS +W+ + Y +
Sbjct: 1882 RTI----TYGPELQANITAGPAEGSPGSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVI 1937
Query: 4865 QFHVACPPDSAL----PCTPSQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEV--GST 4918
+ A P D L + T YT SL L+ TY+ RVVA NE G
Sbjct: 1938 E---ARPSDEGLWDMFVKDIPRSATSYT-----LSLDKLRQGVTYEFRVVAVNEAGYGEP 1989
Query: 4919 ASEWISFTTQKELPQYR-----APFSVDSNLSVVCVNWSDTFLLNGQLKEYVLTDGGRRV 4973
++ + + Q E P Y ++ S + ++ V ++ +L+GQ K+Y G+ +
Sbjct: 1990 SNPSTAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFA--LVLHGQNKKYKNCSTGKGI 2047
Score = 160 bits (405), Expect = 3e-38
Identities = 307/1308 (23%), Positives = 498/1308 (38%), Gaps = 212/1308 (16%)
Query: 3466 LKPYMTYEYRISAWNSYGRGLSKAVRARTK-EDVPQGVSPPTWTKIDNLEDTIVLNWRKP 3524
L P TY++R+ A N GRG A +R + P P +I++ W+ P
Sbjct: 733 LTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPP 792
Query: 3525 --IQSNGPIIYYILLRNGIERFRGTSLSFSDKEGIQP------------FQEYSYQLKAC 3570
+ NG + YIL R G + + P + +Y Q+ A
Sbjct: 793 PETEHNGVLRGYILR----YRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAY 848
Query: 3571 TVAGCATSSKVVAA-TTQGVPESILPP---SITALSAVALHLSWSVPEKS--NGVIKEYQ 3624
AG S+ V T QGVP + PP A+++ + W+ P + NG+ + Y+
Sbjct: 849 NGAGLGVFSRAVTEYTLQGVPTA--PPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYK 906
Query: 3625 I--------RQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTAC--TSAGCTSSEPFLG 3674
+ V I D +T L+ +T Y FT C T S P L
Sbjct: 907 LLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAY-FTSVLCFTTPGDGPPSTPQLV 965
Query: 3675 QTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLS------RNGNLLFLGG 3728
T + P V I++ T++++ W P + NG+++ YQ+S + L
Sbjct: 966 WTQEDKPGAVGHLSFTEILD-TSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLN 1024
Query: 3729 SEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITV--IGP 3786
S + + L + YT + T G+ + + + P+ P N+ + I P
Sbjct: 1025 STTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGV-PPDLPGAPSNLVISNISP 1083
Query: 3787 YSIFV-------------AWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLEN 3833
S + WI G + E V L + P A Q + N
Sbjct: 1084 RSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDA------QMLEIPN 1137
Query: 3834 LTPFTQYEIRIQACQNGSCGVS----SRMFVKTPEAAP-MDLNSPVLKALGSACIEIKWM 3888
LTP+T Y R++ Q G S S ++T +A P + S ++ + ++W+
Sbjct: 1138 LTPYTHYRFRMK--QVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWV 1195
Query: 3889 P-PEKP---NGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRA 3944
P P+ N + Y I + ++ +V V S+ LE + L + YE +++A
Sbjct: 1196 PLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSD-RLEREFTIEELEEWMEYELQMQA 1254
Query: 3945 CNSKGSVESLWSLT---QTLEAPPQDFPA-PWAQATSAHSVLLNWTK--PESPNGIISHY 3998
N+ G+ WS +T E+ P P A+A S+ +LL WT + NG+I Y
Sbjct: 1255 FNAVGA--GPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGY 1312
Query: 3999 RVVYQERPDDPTFNSPTVHAFTVKGTSHQ-AHLYGLEPFTTYRIGVVAANHAGEIL--SP 4055
+++++ + DP P H V+G Q A L GL F Y + V+A G + +P
Sbjct: 1313 KILFRAKDLDP---EPRSH--IVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTP 1367
Query: 4056 WTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNI---------FSDG 4106
L +T + +P G +V + ++ + W P NG+I Y I +
Sbjct: 1368 LILERTKDDAP-GPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFT 1426
Query: 4107 FLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDE-----APPDSQLAP 4161
+E RQF L P + Y L A TR G + T E APP L P
Sbjct: 1427 TVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVP 1486
Query: 4162 TVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERN 4221
V + S+ L W P + IRY T+Q E + E+ T +
Sbjct: 1487 QA-EVTARSLRLQW-VPGSDGASPIRY--------------FTMQVRE-LPRGEWQTYSS 1529
Query: 4222 TFMYNDTG-----LQPWTQCEYKIYTWNSAGHT--CSSWNVVRTLQAPPEGLSPPVISYV 4274
+ + T L+P+T + ++ N G + S V TLQ P G P +S
Sbjct: 1530 SISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVP-GEPPGSVSAT 1588
Query: 4275 SMNPQKLLISWIPP--EQSNGIIQSYRLQRNEMLY-----------------------PF 4309
+LI W PP E NG++Q YR+ E+ Y
Sbjct: 1589 PHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQS 1648
Query: 4310 SFDPVTFNYTD-----EELLPFSTYSYALQACT-SGGCSTSKPTSITTLEAAPSEVSPPD 4363
SF V + T L + Y + A G S P + EAAP+ ++P +
Sbjct: 1649 SFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPA-MAPQN 1707
Query: 4364 LWA--VSATQMNVCWS--PPTVQNGKITKYLVRY---DNKESLAGQGLCLL------VSH 4410
+ ++A+Q+ V W PP QNG I Y + Y D++ + L + +
Sbjct: 1708 VQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKN 1767
Query: 4411 LQPYSQYNFSLVACTNGG-CTASVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPRN 4469
L +++Y S+ A G S + T +A P S ++ ++W P
Sbjct: 1768 LTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAA 1827
Query: 4470 PNGQIRSYELRRDGTIVYTGLE--------------TRYRDFTLTPGVEYSYTVTASN-S 4514
NG ++ Y + + G+ + RD LT GV Y + V A +
Sbjct: 1828 ANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRD--LTKGVTYFFRVQARTIT 1885
Query: 4515 QGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNW------DPPVRTNGDIINYTLF 4568
G L + + +P G L + E+ + W D P T G +I
Sbjct: 1886 YGPELQANITAGPAEGSP-GSPRDVLVTKSASELTLQWTEGHSGDTP--TTGYVIEARPS 1942
Query: 4569 IRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLG 4616
L++ K I + T + + ++L+ YE R+ A G
Sbjct: 1943 DEGLWDMFVKDIPRSATSYTLSL-----DKLRQGVTYEFRVVAVNEAG 1985
Score = 157 bits (396), Expect = 3e-37
Identities = 287/1252 (22%), Positives = 453/1252 (36%), Gaps = 209/1252 (16%)
Query: 3517 IVLNWRKPIQSNGPIIYYIL------------LRNGIERFRGTSLSFSDKEGIQPFQEYS 3564
+VL+W +P N PI+YYI+ L N G ++S G+ P + +
Sbjct: 686 VVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVS-----GLTPAR--T 738
Query: 3565 YQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVA-------LHLSWSVPEKS- 3616
YQ + C V + +PE PPS + VA + + W P ++
Sbjct: 739 YQFRVCAVNEVGRGQYSAETSRLMLPEE--PPSAPPKNIVASGRTNQSIMVQWQPPPETE 796
Query: 3617 -NGVIKEYQIRQVGKGL------IHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGC-TS 3668
NGV++ Y +R GL + + + VT L +T Y + A AG
Sbjct: 797 HNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVF 856
Query: 3669 SEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKP--NGLVSQYQLSRNGNLLFL 3726
S TLQ P + +NSTT++ W+ P + NG+ Y+ LL
Sbjct: 857 SRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYK------LLAW 910
Query: 3727 GGSEEQNFTDKNLEPN----------------SRYTYKLEVKTGGGSSASDDYIVQTPMS 3770
+ T + P+ + +T L T G S +V T
Sbjct: 911 PADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQED 970
Query: 3771 TPEEIYPPYNITVIGPYSIFVAWIPP---GILIPEIPVEYNVL-LNDGSVTPLAFSVGHH 3826
P + + T I S+ V+W P +I + + V ND +T S H
Sbjct: 971 KPGAV-GHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHE 1029
Query: 3827 QSTLLENLTPFTQYEIRIQACQNGSCGV--SSRMFVKTPEAAPMDLNSPVLKALGSACIE 3884
++ L+ T Y I + A G+ SS + P P ++ V+ +
Sbjct: 1030 YK--IQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSAT 1087
Query: 3885 IKWMPPEKPNGIIINYFIYRRPAGI--EEESVLFVWSEGALEF-MDEGDTLRPFTLYEYR 3941
+++ P I + + + I EEE V E + M E L P+T Y +R
Sbjct: 1088 LQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFR 1147
Query: 3942 VRACNSKGSVESLWS--LTQTLEAPPQDFPAPWAQATSAH-SVLLNWT---------KPE 3989
++ N G S + QTL+APP P T++ S+ L W PE
Sbjct: 1148 MKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPE 1207
Query: 3990 SPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHA 4049
S I ++R Q + FT++ LE + Y + + A N
Sbjct: 1208 SVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIE---------ELEEWMEYELQMQAFNAV 1258
Query: 4050 GEILSPWTLI---QTLESSPSGLRNFIVEQKENGRALLLQWSE--PMRTNGVIKTYNIF- 4103
G PW+ + +T ES PS + + + +LL W+ NG+I Y I
Sbjct: 1259 G--AGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILF 1316
Query: 4104 --------SDGFLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPP 4155
+ + L L F LY L + A TR G + P E
Sbjct: 1317 RAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIG--NGVPSTPLILERTK 1374
Query: 4156 DSQLAPTVH----SVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKI 4211
D P V V+ TSV + W P PNG I+ Y++ R + +
Sbjct: 1375 DDAPGPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYR-----------LASSSPH 1423
Query: 4212 VFTEYNTERNTFMYNDTGLQPWTQCEYKIYT-----WNSAGHTCSSWNVVRTLQAPPEGL 4266
FT + T L P + +++ W R APP L
Sbjct: 1424 TFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPREL 1483
Query: 4267 SPPVISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEM------LYPFSFDPVTFNYTD 4320
++ + + L + W+P I+ + +Q E+ Y S
Sbjct: 1484 ---LVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATACVV 1540
Query: 4321 EELLPFSTYSYALQACTSGGCS--TSKPTSITTLEAAPSEVSPPDLWAVSAT-----QMN 4373
+ L PF++Y L+A G S +S+ ++TTL+ P E PP +VSAT +
Sbjct: 1541 DRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGE--PPG--SVSATPHTTSSVL 1596
Query: 4374 VCWSPPTVQ--NGKITKYLVRYDNKESLAGQG---------------------------- 4403
+ W PP + NG + Y + Y E AG G
Sbjct: 1597 IQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSS 1656
Query: 4404 ----LCLLVSHLQPYSQYNFSLVACT-NGGCTASVSKSAWTMEALPENMDSPTLQVT--G 4456
+C L +HL+ Y +Y + A G AS + EA P M +QVT
Sbjct: 1657 STSTMCEL-THLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPA-MAPQNVQVTPLT 1714
Query: 4457 SESIEITW--KPPRNPNGQIRSYEL---------RRDGTIVYTGLETRYRDFTLTPGVEY 4505
+ +E+TW PP + NG I+ Y++ + V E R LT +Y
Sbjct: 1715 ASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKY 1774
Query: 4506 SYTVTASNSQG-GILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTNGDIIN 4564
+++A N+ G G S + RT +AP + V+W P NG +
Sbjct: 1775 LVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQG 1834
Query: 4565 YTLFIREL--FERETKIIHINTTHNSFGMQSYI-VNQLKPFHRYEIRIQACT 4613
Y + L + +K++ + N Q ++ V L Y R+QA T
Sbjct: 1835 YRVVYEPLAPVQGVSKVVTVEVRGN---WQRWLKVRDLTKGVTYFFRVQART 1883
Score = 152 bits (384), Expect = 8e-36
Identities = 253/1071 (23%), Positives = 414/1071 (38%), Gaps = 173/1071 (16%)
Query: 3448 EETIHTGSVNTYSYTDVNLKPYMTYEYRISAWNSYGRGL-SKAVRARTKEDVPQGVSPPT 3506
+ I + VN TD+ + + YE +++A+N G G+ S+AV T + VP
Sbjct: 819 QRNITSPEVNYCLVTDLII--WTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNV 876
Query: 3507 WTKIDNLEDTIVLNWRKPIQS--NGPIIYYILLRNGIERFRGTSLSF--SDKEGI----- 3557
T+ N TI W P Q NG Y LL + ++ D G+
Sbjct: 877 QTEAVN-STTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHI 935
Query: 3558 ---QPFQEYSYQLKACTVAGCAT-SSKVVAATTQGVPESILPPSITALSAVALHLSWSVP 3613
+ F Y + T G S+ + T + P ++ S T + +L +SW P
Sbjct: 936 TNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEP 995
Query: 3614 EKSNGVIKEYQIRQVGKG-----LIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAG--- 3665
+ NG+I YQI G L HT + ++ + GL T Y+ + A T+ G
Sbjct: 996 LEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGL 1055
Query: 3666 CTSSEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQLSR---NGN 3722
TSS G P + P +++I++ + +L +P G + +SR G
Sbjct: 1056 VTSSTISSG-----VPPDLPGAPSNLVISNISPRSA-TLQFRP-GYDGKTSISRWIVEGQ 1108
Query: 3723 LLFLGGSEE-------------QNFTDKNLEPNSRYTYKL-EVKTGGGSSAS-DDYIVQT 3767
+ +G EE Q NL P + Y +++ +V G S S ++QT
Sbjct: 1109 VGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQT 1168
Query: 3768 PMSTPEEIYPPYNITVIGPYSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSVGHHQ 3827
+ P+ + S+ + W+P +P+ +YN G+ + + + + +
Sbjct: 1169 LQAPPDVAPTSVTVRTASETSLRLRWVP----LPD--SQYN-----GNPESVGYRIKYWR 1217
Query: 3828 STL------------------LENLTPFTQYEIRIQACQNGSCG-----VSSRMFVKTPE 3864
S L +E L + +YE+++QA G V R P
Sbjct: 1218 SDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPS 1277
Query: 3865 AAPMDLNSPVLKALGSACIEIKW--MPPEKPNGIIINYFIYRRPAGIEEESVLFV----W 3918
AAP ++++ +A+ S I + W +P + NG+I+ Y I R ++ E +
Sbjct: 1278 AAPENVSA---EAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNH 1334
Query: 3919 SEGALEFMDEGDTLRPFTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAPWAQATSA 3978
++ AL LR F LYE +V A G+ + S LE D P P +
Sbjct: 1335 TQSALL-----AGLRKFVLYELQVLAFTRIGN--GVPSTPLILERTKDDAPGPPVRLVFP 1387
Query: 3979 H----SVLLNWTKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFT---VKGTSHQAHLY 4031
SV + W PE PNGII Y++ Y+ P H FT V T Q
Sbjct: 1388 EVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSP-------HTFTTVEVGATVRQFTAT 1440
Query: 4032 GLEPFTTY--RIGVVAANHAGEILSPWTLIQTLESSPSGLRNFIVEQKE-NGRALLLQW- 4087
L P + Y R+ GE L + P+ R +V Q E R+L LQW
Sbjct: 1441 DLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWV 1500
Query: 4088 -----SEPMR---------TNGVIKTYNIFSDGFLEYSGLNRQFLFRRLDPFTLYTLTLE 4133
+ P+R G +TY+ S + RL PFT Y L L+
Sbjct: 1501 PGSDGASPIRYFTMQVRELPRGEWQTYS------SSISHEATACVVDRLRPFTSYKLRLK 1554
Query: 4134 ACTRAGCAH-----SAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNP--NGKII 4186
A G + A L P ++ T H+ ++SV + W P + NG +
Sbjct: 1555 ATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHT--TSSVLIQWQPPRDESLNGLLQ 1612
Query: 4187 RYEVIRRCFEGKAWGNQTIQADEKIV-----------FTEYNTERNTFMYNDTGLQPWTQ 4235
Y + R E +A + + + F N+ + M T L+ + +
Sbjct: 1613 GYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRR 1672
Query: 4236 CEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPPVISYVSMNPQKLLISW--IPPEQSNG 4293
E + +N G + +S V + ++P + + +L ++W PPE NG
Sbjct: 1673 YEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDPPPPESQNG 1732
Query: 4294 IIQSYRL---------QRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGGCS-T 4343
IQ Y++ + +M F +PV + L + Y ++ A + G
Sbjct: 1733 NIQGYKIYYWEADSQNETEKMKVLFLPEPVV---RLKNLTSHTKYLVSISAFNAAGDGPK 1789
Query: 4344 SKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPPTVQNGKITKYLVRYD 4394
S P T +AAP S +++T +NV W P NG + Y V Y+
Sbjct: 1790 SDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYE 1840
Score = 149 bits (377), Expect = 5e-35
Identities = 254/1102 (23%), Positives = 433/1102 (39%), Gaps = 135/1102 (12%)
Query: 1924 FTEYLYRVIASHEGG-SVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEP---V 1979
+T+Y +V A + G V+S T P + P + ++N +I+ W+ P
Sbjct: 838 WTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQF 897
Query: 1980 VRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAG 2039
+ G+ + Y L A+ D+ + + + +F + G +T L F Y ++ T G
Sbjct: 898 INGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHH--GHITNLKKFTAYFTSVLCFTTPG 955
Query: 2040 CTESSHALNISTPQEAPQEV-QPPVAKSLPSSLLLSWNPPKKANGIITQYCLYM------ 2092
S + T ++ P V + L +SL +SW P + NGIIT Y +
Sbjct: 956 DGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRN 1015
Query: 2093 DGRLIY--SGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSP- 2149
D RL + + + Y + L+ T + ++A T VG T ++ +PP+ +P
Sbjct: 1016 DSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVG-TGLVTSSTISSGVPPDLPGAPS 1074
Query: 2150 --VLTVLDSRTIHIQWKQPRKISGILERYVLY-MSNHTHDFTIWSVIYNSTELFQDHMLQ 2206
V++ + R+ +Q++ + R+++ D W +Y ML+
Sbjct: 1075 NLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEENEPDAQMLE 1134
Query: 2207 Y--VLPGNKYLIKLGACT-GGGCTVSEASEALTDEDIPEGVPAPKA---HSYSPDSFNVS 2260
+ P Y ++ G S +S + P V AP + + S S +
Sbjct: 1135 IPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDV-APTSVTVRTASETSLRLR 1193
Query: 2261 WT---EPEYPNGVITSYGLYLD-----------GILIHNSSELSYRAYGFAPWSLHSFRV 2306
W + +Y NG S G + ++ + E + W + ++
Sbjct: 1194 WVPLPDSQY-NGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQM 1252
Query: 2307 QACTAKGCALGP---LVENRTLEAPPEGT-VNVFVKTQGSRKAHVRWEA--PFRPNGLLT 2360
QA A G GP +V RT E+ P NV + S + + W + NGL+
Sbjct: 1253 QAFNAVGA--GPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLIL 1310
Query: 2361 HSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGS 2420
+ +DP ++ + G T L+ GL F Y +QV G+
Sbjct: 1311 GYKILFRAKDLDPEPRSH--------IVRGNHTQS-ALLAGLRKFVLYELQVLAFTRIGN 1361
Query: 2421 LI-TDPITIAM----PPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRS 2475
+ + P+ + PG P ++ P + TS+++VW P N YQ+ R
Sbjct: 1362 GVPSTPLILERTKDDAPGPPVRLVFPEVRL---TSVRIVWQPPEEPNGI-ILGYQIAYRL 1417
Query: 2476 GDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAEDKPGP 2535
S+ + + +DL P + Y+FRL A G +T E + P
Sbjct: 1418 ASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKRERP 1477
Query: 2536 VVPPILL----DVKSRMMLVTWQHPRKSNGVITHYNIYL------HGRLYLRTPGN-VTN 2584
P LL +V +R + + W I ++ + + + Y + + T
Sbjct: 1478 APPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEATA 1537
Query: 2585 CTVMHLHPYTAYKFQVEACTSKGCS-LSPESQTVWTL---PGAPEGIPSPELFSDTPTSV 2640
C V L P+T+YK +++A G S S E++ V TL PG P G S T +SV
Sbjct: 1538 CVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPG--SVSATPHTTSSV 1595
Query: 2641 IISWQPPTHP--NGLVENFTI-----ERRVKGKEEVTTL-------VTLPRSHSMRFIDK 2686
+I WQPP NGL++ + I E E TL L S + ++
Sbjct: 1596 LIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNS 1655
Query: 2687 TSA--------LSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPA-GVQPPVVTVLEP 2737
+S L + +YE + + G + +SA VEV + PA Q VT L
Sbjct: 1656 SSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTA 1715
Query: 2738 DAVQVTW--KPPLIQNGDILSYEIHM--PDPHITLTNVTSAVLSQKVTHLIPFTNYSVTI 2793
++VTW PP QNG+I Y+I+ D + L + V L T+++ +
Sbjct: 1716 SQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYL 1775
Query: 2794 VACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPNLR 2853
V+ S N G +S P TH P L+ ++ + + +SW P+ NG
Sbjct: 1776 VSISAFNA-AGDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQG 1834
Query: 2854 YELLRRKIQQPLASNPPEDLNRWHNIYSGTQW--LYEDKGLSRFTTYEYMLFVHNSVGFT 2911
Y R + +PLA P + +++ + W + + L++ TY +
Sbjct: 1835 Y----RVVYEPLA--PVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFF----------- 1877
Query: 2912 PSREVTVTTLAGLPERGANLTA 2933
V T+ PE AN+TA
Sbjct: 1878 ---RVQARTITYGPELQANITA 1896
Score = 137 bits (345), Expect = 3e-31
Identities = 191/798 (23%), Positives = 316/798 (39%), Gaps = 81/798 (10%)
Query: 2407 NYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGS 2466
+Y+ ++ S + I +P + ++ P S + L W P N+P
Sbjct: 644 DYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLS--WVRPFDGNSP-- 699
Query: 2467 PRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPF 2526
Y + S +++ + L + VS L P Y FR+ A N G S
Sbjct: 700 ILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETS 759
Query: 2527 MTAEDKPGPVVPPILLDVKSRM---MLVTWQHPRKS--NGVITHYNIY-----LHGRLYL 2576
+ P PP + R ++V WQ P ++ NGV+ Y + L G
Sbjct: 760 RLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQ 819
Query: 2577 R--TPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGIP-SPELF 2633
R T V C V L +T Y+ QV A G + + T +TL G P P + +
Sbjct: 820 RNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTE 879
Query: 2634 SDTPTSVIISWQPPTHP--NGLVENFTIERRVKGKEEVTTLVTL-PRSHSMRFIDKTSAL 2690
+ T++ W PP NG+ + + + E T+VT+ P H + T+ L
Sbjct: 880 AVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITN-L 938
Query: 2691 SPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQ 2750
+T Y VL T G S V T+ +P V T + +++V+W+ PL +
Sbjct: 939 KKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEK 998
Query: 2751 NGDILSYEIHMP-----DPHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSG-GNGYLG 2804
NG I Y+I D +T T + S K+ L T Y++ + A + G G +
Sbjct: 999 NGIITGYQISWEVYGRNDSRLTHT-LNSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVT 1057
Query: 2805 GCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQP 2864
T S P +P L + +S + ++P G + + + R ++
Sbjct: 1058 SSTISSGV----PPDLPGAPSNLVISNISPRSATLQFRP-----GYDGKTSISRWIVEGQ 1108
Query: 2865 LASNPPEDLNRWHNIYSGTQ----WLYEDKGLSRFTTYEYMLFVHNSVG---FTPSREVT 2917
+ + E+ W +Y + E L+ +T Y + + N VG ++PS V
Sbjct: 1109 VGAIGDEE--EWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVI 1166
Query: 2918 VTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDLQGEVE---YYTLFWSSATSNDSL- 2973
T A ++T + T++ +RW G E Y +W S + ++
Sbjct: 1167 QTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVA 1226
Query: 2974 KILPD--VNSHVIGHLKPNTEYWIFISVFNGVHSINSAGLHATTCDGEPQGMLP---PEV 3028
+++ D I L+ EY + + FN V AG + G + +P PE
Sbjct: 1227 QVVSDRLEREFTIEELEEWMEYELQMQAFNAV----GAGPWSEVVRGRTRESVPSAAPEN 1282
Query: 3029 V---IINSTAVRVIWTS--PSNPNGVVTEYSIYVNNK-------LYKTGMNVPGSFILRD 3076
V ++ST + + WTS + NG++ Y I K + N S +L
Sbjct: 1283 VSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAG 1342
Query: 3077 LSPFTIYDIQVEVCTIYACVKSNGTQITTV--EDTPSDIPTPTIR----GITSRSLQIDW 3130
L F +Y++QV T NG T + E T D P P +R + S++I W
Sbjct: 1343 LRKFVLYELQVLAFTRIG----NGVPSTPLILERTKDDAPGPPVRLVFPEVRLTSVRIVW 1398
Query: 3131 VSPRKPNGIILGYDLLWK 3148
P +PNGIILGY + ++
Sbjct: 1399 QPPEEPNGIILGYQIAYR 1416
Score = 115 bits (287), Expect = 1e-24
Identities = 176/724 (24%), Positives = 285/724 (39%), Gaps = 83/724 (11%)
Query: 3465 NLKPYMTYEYRISAWNSYGRG-LSKAVRARTKEDVPQGVSPPTWTKIDNLEDTIVLNWRK 3523
NL PY Y +R+ N G S + R P V+P + T E ++ L W
Sbjct: 1137 NLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRW-V 1195
Query: 3524 PI---QSNG---PIIYYILLRNGIERFRGTSLSFSDK-------EGIQPFQEYSYQLKAC 3570
P+ Q NG + Y I + + SD+ E ++ + EY Q++A
Sbjct: 1196 PLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEWMEYELQMQAF 1255
Query: 3571 TVAGCATSSKVVAATTQGVPESILPPSITA--LSAVALHLSW-SVPEKS-NGVIKEYQIR 3626
G S+VV T+ S P +++A +S+ + L+W SVPE+ NG+I Y+I
Sbjct: 1256 NAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKIL 1315
Query: 3627 QVGKGLIHTDTTD--RRQHT----VTGLQPYTNYSFTLTACTSAG--CTSSEPFLGQTLQ 3678
K L + R HT + GL+ + Y + A T G S+ L +T
Sbjct: 1316 FRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKD 1375
Query: 3679 AAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQL-------SRNGNLLFLGGSEE 3731
AP G V + T+V + W PE+PNG++ YQ+ S + G+
Sbjct: 1376 DAP-GPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTVEVGATV 1434
Query: 3732 QNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQTPMSTPEEIYPPYNITV----IGPY 3787
+ FT +L P S Y ++L KT G + V T E PP + V +
Sbjct: 1435 RQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKR-ERPAPPRELLVPQAEVTAR 1493
Query: 3788 SIFVAWIPPGILIPEIPVEYNVL----LNDGSVTPLAFSVGHHQST-LLENLTPFTQYEI 3842
S+ + W+P P+ Y + L G + S+ H + +++ L PFT Y++
Sbjct: 1494 SLRLQWVPGSD--GASPIRYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKL 1551
Query: 3843 RIQACQN-GSCGVSSRM-FVKTPEAAPMDLNSPVLKALGS-ACIEIKWMPP--EKPNGII 3897
R++A + G SS V T + P + V + + + I+W PP E NG++
Sbjct: 1552 RLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLL 1611
Query: 3898 INYFIYRRP---------------------AGIEEESVLFVWSEGALEFMDEGDTLRPFT 3936
Y IY R A + +S + + M E L+ +
Sbjct: 1612 QGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYR 1671
Query: 3937 LYEYRVRACNSKGSVESLWSLTQTL-EAPPQDFPAPWAQAT--SAHSVLLNWTKP--ESP 3991
YE + A N G + + + EA P P Q T +A + + W P ES
Sbjct: 1672 RYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQN-VQVTPLTASQLEVTWDPPPPESQ 1730
Query: 3992 NGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGE 4051
NG I Y++ Y E + T + L L T Y + + A N AG+
Sbjct: 1731 NGNIQGYKIYYWEADSQ----NETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGD 1786
Query: 4052 ILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFLEYS 4111
+ G +F+ + L + W EP NG+++ Y + +
Sbjct: 1787 GPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQ 1846
Query: 4112 GLNR 4115
G+++
Sbjct: 1847 GVSK 1850
Score = 114 bits (286), Expect = 2e-24
Identities = 272/1236 (22%), Positives = 464/1236 (37%), Gaps = 183/1236 (14%)
Query: 2055 APQEVQPPVAKSLPSSLLLSWNPPKKANGIITQYCLYMDGR-------LIYSGSE-ENYT 2106
+PQ + S +++LSW P N I Y + + L G E T
Sbjct: 670 SPQNLLVSPNSSHSHAVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVT 729
Query: 2107 VTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQLPPEHVDSPVLTVLDS----RTIHIQ 2162
V+ L +QF + A VG S LP E +P ++ S ++I +Q
Sbjct: 730 VSGLTPARTYQFRVCAVNEVGRGQYS-AETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQ 788
Query: 2163 WKQPRKI--SGILERYVLY-----MSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYL 2215
W+ P + +G+L Y+L + I S N ++ ++ +Y
Sbjct: 789 WQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYC------LVTDLIIWTQYE 842
Query: 2216 IKLGACTGGGCTVSEASEALTDEDIPEGVPAPKAHSYSPDSFNVS-----WTEP--EYPN 2268
I++ A G G V S A+T+ + +GVP + ++ N + W P ++ N
Sbjct: 843 IQVAAYNGAGLGVF--SRAVTEYTL-QGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFIN 899
Query: 2269 GVITSYGLYL------DGILIHNSSELSYRAYGFAPWSLHSFR-----VQACTAKGCALG 2317
G+ Y L + + + + + + +L F V T G G
Sbjct: 900 GINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGD--G 957
Query: 2318 PLVENR---TLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPV 2374
P + T E P ++ V W+ P NG++T + ++ +
Sbjct: 958 PPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEVYGRNDS 1017
Query: 2375 GNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPITIA--MPP 2432
+TL N T Y I GL T YT+ V + G+ + TI+ +PP
Sbjct: 1018 RLTHTL-NSTTHEYK---------IQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVPP 1067
Query: 2433 GAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQLQMRSG-----DSTHGFLELFS 2487
P +S+ +P S + + P + R+ ++ + G + E +
Sbjct: 1068 DLPGAPSNLVISNISPRSATLQFR-PGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEEN 1126
Query: 2488 NPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAEDKPGPVVPPILLDVKSR 2547
P A + E+ +L PYT Y FR+ N G + S + + P V P + V++
Sbjct: 1127 EPDAQM-LEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTA 1185
Query: 2548 M---MLVTW----QHPRKSNGVITHYNI-YLHGRLYLRTPGNVTN------CTVMHLHPY 2593
+ + W N Y I Y L V + T+ L +
Sbjct: 1186 SETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEELEEW 1245
Query: 2594 TAYKFQVEACTSKGCSLSPE---SQTVWTLPGA-PEGIPSPELFSDTPTSVIISWQ--PP 2647
Y+ Q++A + G E +T ++P A PE + + + S T ++++W P
Sbjct: 1246 MEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSS---TQILLTWTSVPE 1302
Query: 2648 THPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSAL----SPWTKYEYRVLMS 2703
NGL+ + I R K + PRSH +R SAL + YE +VL
Sbjct: 1303 QDQNGLILGYKILFRAKDLDPE------PRSHIVRGNHTQSALLAGLRKFVLYELQVLAF 1356
Query: 2704 TLHG-GTNSSAWVEVTTRPSRPAGVQPPVVTVLEP---DAVQVTWKPPLIQNGDILSYEI 2759
T G G S+ + T+ P PPV V +V++ W+PP NG IL Y+I
Sbjct: 1357 TRIGNGVPSTPLILERTKDDAPG---PPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQI 1413
Query: 2760 HM----PDPH-ITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYV 2814
PH T V + V T L P + Y + A + G E L V
Sbjct: 1414 AYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQ-----GWGEPLEATV 1468
Query: 2815 TT-----HPTVPQNVGPLSVIPLSE---SYVVISWQPPSKPNGPNLRYELLRRKIQQPLA 2866
T P P+ + ++P +E + + W P S P + + R++
Sbjct: 1469 ITTEKRERPAPPREL----LVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVREL----- 1519
Query: 2867 SNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTP--SREVTVTTLAGL 2924
P + + + S L FT+Y+ L N +G + S VTTL +
Sbjct: 1520 --PRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDV 1577
Query: 2925 P-ERGANLTASVLNHTAIDVRWAKPTVQDLQGEVEYYTLFW------------------- 2964
P E +++A+ +++ ++W P + L G ++ Y +++
Sbjct: 1578 PGEPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNP 1637
Query: 2965 ----SSATSNDSLKILPDVNSHV---IGHLKPNTEYWIFISVFNGV-HSINSAGLHATTC 3016
+ T+ S K + ++ + HLK Y + ++ +N + S SA +
Sbjct: 1638 IALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVG 1697
Query: 3017 DGEPQGMLPPEVVIINSTA--VRVIWTSP--SNPNGVVTEYSIYV------NNKLYKTGM 3066
+ P M P V + TA + V W P + NG + Y IY N +
Sbjct: 1698 EAAP-AMAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVL 1756
Query: 3067 NVPGSFI-LRDLSPFTIYDIQVEVCTIYAC-VKSNGTQITTVEDTPSDIPTPTIRGITSR 3124
+P + L++L+ T Y + + KS+ Q T + P ITS
Sbjct: 1757 FLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFLAFSEITST 1816
Query: 3125 SLQIDWVSPRKPNGIILGYDLLWKTWYPCAKTQKLV 3160
+L + W P NGI+ GY ++++ P K+V
Sbjct: 1817 TLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVV 1852
Score = 110 bits (274), Expect = 5e-23
Identities = 202/884 (22%), Positives = 321/884 (36%), Gaps = 132/884 (14%)
Query: 2329 PEGTVNVFVKTQGSRKAHV--RWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKV 2386
P N+ V S V W PF N + ++Y+ + N + V
Sbjct: 668 PHSPQNLLVSPNSSHSHAVVLSWVRPFDGNSPI--------LYYIVELSENNSPWKVHLS 719
Query: 2387 MYSGEETNLWVLIDGLVPFTNYTVQVNISNS--QGSLITDPITIAMPPGAPDGVLPPR-- 2442
E T V + GL P Y +V N +G + + +P P PP+
Sbjct: 720 NVGPEMTG--VTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLMLPEEPPSA--PPKNI 775
Query: 2443 -LSSATPTSLQVVWSTPARNNAPGSPR-YQLQMRSGDSTHGFLELFSNPSASLSY-EVSD 2499
S T S+ V W P G R Y L+ R G + + S ++Y V+D
Sbjct: 776 VASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLA-GLPGEYQQRNITSPEVNYCLVTD 834
Query: 2500 LQPYTEYMFRLVASNGFG-SAHSSWIPFMTAEDKPGPVVPPILLD---VKSRMMLVTWQH 2555
L +T+Y ++ A NG G S + T + P PP + V S + W
Sbjct: 835 LIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVP--TAPPQNVQTEAVNSTTIQFLWNP 892
Query: 2556 PRKS--NGVITHYNIYLHGRLYLRTPGNVTNCTVM------------HLHPYTAYKFQVE 2601
P + NG+ Y + P VT T+ +L +TAY V
Sbjct: 893 PPQQFINGINQGYKLLAWPA---DAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVL 949
Query: 2602 ACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIER 2661
T+ G Q VWT P + TS+ +SWQ P NG++ + I
Sbjct: 950 CFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISW 1009
Query: 2662 RVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHG-GTNSSAWVEVTTR 2720
V G+ + TL +S K LS T Y V T G G +S+ +
Sbjct: 1010 EVYGRNDSRLTHTL---NSTTHEYKIQGLSSLTTYTIDVAAVTAVGTGLVTSSTISSGVP 1066
Query: 2721 PSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSY-------EIHMPDPHITLTNVTS 2773
P P V++ + P + + ++P I + I + +TL +
Sbjct: 1067 PDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEEN 1126
Query: 2774 AVLSQ--KVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVI- 2830
+Q ++ +L P+T+Y + + +G S + V P +V P SV
Sbjct: 1127 EPDAQMLEIPNLTPYTHYRFRMKQVN----IVGPSPYSPSSRVIQTLQAPPDVAPTSVTV 1182
Query: 2831 -PLSESYVVISWQP------PSKPNGPNLRYELLRRKIQQPLASNPPED-LNRWHNIYSG 2882
SE+ + + W P P R + R +Q + D L R I
Sbjct: 1183 RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLEREFTIEEL 1242
Query: 2883 TQWLYEDKGLSRFTTYEYMLFVHNSVGFTP-SREVTVTTLAGLPERG-ANLTASVLNHTA 2940
+W+ YE + N+VG P S V T +P N++A ++ T
Sbjct: 1243 EEWM----------EYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQ 1292
Query: 2941 IDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVI--GHLKP--------- 2989
I + W QD G + Y + + + + P+ SH++ H +
Sbjct: 1293 ILLTWTSVPEQDQNGLILGYKILFRAKDLD------PEPRSHIVRGNHTQSALLAGLRKF 1346
Query: 2990 ---NTEYWIFISVFNGVHSINSAGLHATTCD--GEPQGMLPPEVVIINSTAVRVIWTSPS 3044
+ F + NGV S L T D G P ++ PEV + T+VR++W P
Sbjct: 1347 VLYELQVLAFTRIGNGVPS-TPLILERTKDDAPGPPVRLVFPEVRL---TSVRIVWQPPE 1402
Query: 3045 NPNGVVTEYSIYVNNKLYKTGMNVPGSFILRDLS----PFTIYDIQVEVCTIYACVKS-- 3098
PNG++ Y I Y+ + P +F ++ FT D+ E I+
Sbjct: 1403 EPNGIILGYQI-----AYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTR 1457
Query: 3099 -------NGTQITTVE----DTPSDIPTPTIRGITSRSLQIDWV 3131
T ITT + P ++ P +T+RSL++ WV
Sbjct: 1458 QGWGEPLEATVITTEKRERPAPPRELLVPQAE-VTARSLRLQWV 1500
Score = 102 bits (255), Expect = 8e-21
Identities = 115/453 (25%), Positives = 188/453 (41%), Gaps = 39/453 (8%)
Query: 1068 SAINLSWSPPDSPN----AHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSY 1123
+++ + W PP+ PN + + Y L +TT + +++ F TDL P + Y +
Sbjct: 1392 TSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFTTV-EVGATVRQFTATDLAPESAYIF 1450
Query: 1124 YIETTNVHG----STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLSNQSGPI 1179
+ G +V T K + P L + + + S+ L W S+ + PI
Sbjct: 1451 RLSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQ-AEVTARSLRLQWVPGSDGASPI 1509
Query: 1180 EKYILSCAPLAGG--QPCVSYEGHE-TSATIWNLVPFAKYDFSVQACTSGG--CLHSLPI 1234
+ + L G Q S HE T+ + L PF Y ++A G S
Sbjct: 1510 RYFTMQVRELPRGEWQTYSSSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETE 1569
Query: 1235 TVTTAQAPPQRLSPP---KMQKISSTELHVEWSPPAE--LNGIIIRYELYMRRLRSTKET 1289
VTT Q P PP +++ + ++W PP + LNG++ Y +Y R L +
Sbjct: 1570 AVTTLQDVPG--EPPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGS 1627
Query: 1290 TSEESRV---FQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG 1346
+E + L+ S ++ N ++ TM +T L+ Y +YE + A N+ G
Sbjct: 1628 GTEAKTLKNPIALHAELTAQSSFKTVNSSS---TSTMCELTHLKKYRRYEVIMTAYNIIG 1684
Query: 1347 -SVSSAWVSERTGESAPVFMIPPS--VFPLSSYSLNISWEKPADNVTRGKVVGYDINMLS 1403
S +SA V GE+AP M P + V PL++ L ++W+ P G + GY I
Sbjct: 1685 ESPASAPVEVFVGEAAPA-MAPQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWE 1743
Query: 1404 EQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVG-CVTSASGAGQT 1462
S ++ M L E ++ L + Y +I+ N+ G S G+T
Sbjct: 1744 ADSQNETEKMKVLFL------PEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRT 1797
Query: 1463 LAAAPAQLRPPLVKGINSTTIHLKWFPPEELNG 1495
AAP I STT+++ W P NG
Sbjct: 1798 HQAAPGAPSFLAFSEITSTTLNVSWGEPAAANG 1830
Score = 76.3 bits (186), Expect = 8e-13
Identities = 143/614 (23%), Positives = 232/614 (37%), Gaps = 98/614 (15%)
Query: 1921 LQPFTEYLYRVIASHE-GGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTW---D 1976
L+ + EY ++ A + G +S+ RGRT + P + P +++ I +TW
Sbjct: 1242 LEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVP 1301
Query: 1977 EPVVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACT 2036
E G+I Y + ++D PR ++ +L GL F Y + + A T
Sbjct: 1302 EQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSA----LLAGLRKFVLYELQVLAFT 1357
Query: 2037 LAGCTESSHALNIS-TPQEAPQEVQPPVAKSLP----SSLLLSWNPPKKANGIITQYCL- 2090
G S L + T +AP PPV P +S+ + W PP++ NGII Y +
Sbjct: 1358 RIGNGVPSTPLILERTKDDAP---GPPVRLVFPEVRLTSVRIVWQPPEEPNGIILGYQIA 1414
Query: 2091 --------YMDGRLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLLYTAQ-- 2140
+ + + +T TDLA + + F LSA T G + T +
Sbjct: 1415 YRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIFRLSAKTRQGWGEPLEATVITTEKR 1474
Query: 2141 ---LPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSN------HTHDFTIWS 2191
PP + P V +R++ +QW + + + + + T+ S
Sbjct: 1475 ERPAPPRELLVPQAEV-TARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSS---S 1530
Query: 2192 VIYNSTELFQDHMLQYVLPGNKYLIKLGACTG-GGCTVSEASEALTD-EDIPEGVP-APK 2248
+ + +T D + P Y ++L A G S +EA+T +D+P P +
Sbjct: 1531 ISHEATACVVDRL----RPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVS 1586
Query: 2249 AHSYSPDSFNVSWTEP--EYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLH---- 2302
A ++ S + W P E NG++ Y +Y + S + P +LH
Sbjct: 1587 ATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLK-NPIALHAELT 1645
Query: 2303 ---SFRV--QACTAKGCALGPLVENRTLE-------------------------APPEGT 2332
SF+ + T+ C L L + R E AP
Sbjct: 1646 AQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAP 1705
Query: 2333 VNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEE 2392
NV V + + V W+ P P ++ I+Y + N T KV++ E
Sbjct: 1706 QNVQVTPLTASQLEVTWDPP--PPESQNGNIQGYKIYYWEADSQNET--EKMKVLFLPEP 1761
Query: 2393 TNLWVLIDGLVPFTNYTVQVNISNSQG-SLITDP---ITIAMPPGAPDGVLPPRLSSATP 2448
V + L T Y V ++ N+ G +DP T PGAP + S T
Sbjct: 1762 V---VRLKNLTSHTKYLVSISAFNAAGDGPKSDPQQGRTHQAAPGAPSFL---AFSEITS 1815
Query: 2449 TSLQVVWSTPARNN 2462
T+L V W PA N
Sbjct: 1816 TTLNVSWGEPAAAN 1829
Score = 72.0 bits (175), Expect = 1e-11
Identities = 107/433 (24%), Positives = 172/433 (39%), Gaps = 55/433 (12%)
Query: 1110 FLDTDLLPYTKYSYYIETTNVHGSTR-SVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLT 1168
F +L + +Y ++ N G+ S V +T+ VP + S + LT
Sbjct: 1237 FTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSSTQILLT 1296
Query: 1169 WTTL--SNQSGPIEKY-ILSCAPLAGGQPC--VSYEGHETSATIWNLVPFAKYDFSVQAC 1223
WT++ +Q+G I Y IL A +P + H SA + L F Y+ V A
Sbjct: 1297 WTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAF 1356
Query: 1224 TS-GGCLHSLPI----TVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYEL 1278
T G + S P+ T A PP RL P+++ T + + W PP E NGII+ Y++
Sbjct: 1357 TRIGNGVPSTPLILERTKDDAPGPPVRLVFPEVRL---TSVRIVWQPPEEPNGIILGYQI 1413
Query: 1279 YMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFR 1338
R S SPH+F ++ T T L P + Y FR
Sbjct: 1414 AYRLASS------------------SPHTFTTVEVGATVR----QFTATDLAPESAYIFR 1451
Query: 1339 VLAVNMAG----SVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTRGKV 1394
+ A G ++ +E+ AP + +++ SL + W +D + +
Sbjct: 1452 LSAKTRQGWGEPLEATVITTEKRERPAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRY 1511
Query: 1395 VGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVG--C 1452
M + P+ S + H A + V+ L+P+ Y+ + N +G
Sbjct: 1512 ----FTMQVRELPRGEWQTYSSSISHEA----TACVVDRLRPFTSYKLRLKATNDIGDSD 1563
Query: 1453 VTSASGAGQTLAAAPAQLRPPLVKGINSTT--IHLKWFPP--EELNGPSPIYQLERRESS 1508
+S + A TL P + P V TT + ++W PP E LNG Y++ RE
Sbjct: 1564 FSSETEAVTTLQDVPGE-PPGSVSATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELE 1622
Query: 1509 LPALMTTMMKGIR 1521
A T K ++
Sbjct: 1623 YEAGSGTEAKTLK 1635
Score = 66.6 bits (161), Expect = 6e-10
Identities = 102/391 (26%), Positives = 154/391 (39%), Gaps = 50/391 (12%)
Query: 2788 NYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESY--VVISWQPPS 2845
+YS IV+ GGN E V P PQN L V P S VV+SW P
Sbjct: 644 DYSCEIVS-EGGNDSRMARLE-----VIELPHSPQN---LLVSPNSSHSHAVVLSWVRPF 694
Query: 2846 KPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWL-YEDKGLSRFTTYEYMLFV 2904
N P L Y I + +N P + H G + GL+ TY++ +
Sbjct: 695 DGNSPILYY------IVELSENNSPWKV---HLSNVGPEMTGVTVSGLTPARTYQFRVCA 745
Query: 2905 HNSVGFTPSREVTVTTLAGLPERGA-----NLTASVLNHTAIDVRWAKPTVQDLQGEVEY 2959
N VG + T+ LPE N+ AS + +I V+W P + G +
Sbjct: 746 VNEVG--RGQYSAETSRLMLPEEPPSAPPKNIVASGRTNQSIMVQWQPPPETEHNGVLRG 803
Query: 2960 YTLFWSSATSNDSLK----ILPDVNSHVIGHLKPNTEYWIFISVFNGVH-SINSAGLHAT 3014
Y L + A + P+VN ++ L T+Y I ++ +NG + S +
Sbjct: 804 YILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEY 863
Query: 3015 TCDGEPQGMLPPEVV---IINSTAVRVIWTSPSNP--NGVVTEYSIYV---NNKLYKTGM 3066
T G P PP+ V +NST ++ +W P NG+ Y + + T +
Sbjct: 864 TLQGVPTA--PPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVV 921
Query: 3067 NVPGSFI------LRDLSPFTIYDIQVEVCTIYACVKSNGTQIT-TVEDTPSDIPTPTIR 3119
+ F + +L FT Y V T + Q+ T ED P + +
Sbjct: 922 TIAPDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFT 981
Query: 3120 GITSRSLQIDWVSPRKPNGIILGYDLLWKTW 3150
I SL++ W P + NGII GY + W+ +
Sbjct: 982 EILDTSLKVSWQEPLEKNGIITGYQISWEVY 1012
Score = 64.7 bits (156), Expect = 2e-09
Identities = 183/878 (20%), Positives = 314/878 (35%), Gaps = 133/878 (15%)
Query: 1921 LQPFTEYLYRVIASH-EGGSVYSDWSRG-RTTGAAPQSVPTPSRVRSLNGYSIEVTW--- 1975
L P+T Y +R+ + G S YS SR +T A P PT VR+ + S+ + W
Sbjct: 1138 LTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPL 1197
Query: 1976 DEPVVRGVIEK--YILKAYSEDSTRPPRMPSASAEFVNTSNLTGILT--GLLPFKNYAVT 2031
+ G E Y +K + D + S++ V + L T L + Y +
Sbjct: 1198 PDSQYNGNPESVGYRIKYWRSD------LQSSAVAQVVSDRLEREFTIEELEEWMEYELQ 1251
Query: 2032 LTACTLAGCTESSHAL----NISTPQEAPQEVQPPVAKSLPSSLLLSWN--PPKKANGII 2085
+ A G S + S P AP+ V S + +LL+W P + NG+I
Sbjct: 1252 MQAFNAVGAGPWSEVVRGRTRESVPSAAPENVSAEAVSS--TQILLTWTSVPEQDQNGLI 1309
Query: 2086 TQYCLYMDGR---------LIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWVLL 2136
Y + + ++ ++ + L F ++ + A T +G S L+
Sbjct: 1310 LGYKILFRAKDLDPEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLI 1369
Query: 2137 Y-----TAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYVL---YMSNHTHDFT 2188
A PP + P + + ++ I W+ P + +GI+ Y + S+ H FT
Sbjct: 1370 LERTKDDAPGPPVRLVFPEVRL---TSVRIVWQPPEEPNGIILGYQIAYRLASSSPHTFT 1426
Query: 2189 IWSV-----IYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEASEALTDEDIPEG 2243
V + +T+L P + Y+ +L A T G + +T E
Sbjct: 1427 TVEVGATVRQFTATDL---------APESAYIFRLSAKTRQGWGEPLEATVITTEKRER- 1476
Query: 2244 VPAPKAHSYSPD------SFNVSWTEPEYPNGVITSYGLYL----DGILIHNSSELSYRA 2293
PAP P S + W I + + + G SS +S+ A
Sbjct: 1477 -PAPPRELLVPQAEVTARSLRLQWVPGSDGASPIRYFTMQVRELPRGEWQTYSSSISHEA 1535
Query: 2294 YG-----FAPWSLHSFRVQACTAKG-----CALGPLVENRTLEAPPEGTVNVFVKTQGSR 2343
P++ + R++A G + + + P G+V+ T S
Sbjct: 1536 TACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPGEPPGSVSATPHTTSS- 1594
Query: 2344 KAHVRWEAPFRP--NGLLT-HSVLFTGIFYVDPVGNNYTLLNVTKVMY------------ 2388
++W+ P NGLL + + + + Y G L ++
Sbjct: 1595 -VLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKTLKNPIALHAELTAQSSFKTV 1653
Query: 2389 SGEETNLWVLIDGLVPFTNYTVQVNISNSQG-SLITDPITI----AMPPGAPDGVLPPRL 2443
+ T+ + L + Y V + N G S + P+ + A P AP V ++
Sbjct: 1654 NSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNV---QV 1710
Query: 2444 SSATPTSLQVVWSTP----ARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSD 2499
+ T + L+V W P N G Y + S + T LF + +
Sbjct: 1711 TPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPV---VRLKN 1767
Query: 2500 LQPYTEYMFRLVASNGFGSAHSSWIPFMTAEDKPGPVVPPILL--DVKSRMMLVTWQHPR 2557
L +T+Y+ + A N G S P + P P L ++ S + V+W P
Sbjct: 1768 LTSHTKYLVSISAFNAAGDGPKS-DPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPA 1826
Query: 2558 KSNGVITHYNIYLHGRLYLRTPGNVTN----------CTVMHLHPYTAYKFQVEACTSKG 2607
+NG++ Y + ++ V V L Y F+V+A T
Sbjct: 1827 AANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKVRDLTKGVTYFFRVQART--- 1883
Query: 2608 CSLSPESQ---TVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVK 2664
+ PE Q T G+P G P L + + + + + W + + IE R
Sbjct: 1884 ITYGPELQANITAGPAEGSP-GSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIEARPS 1942
Query: 2665 GKEEVTTLV-TLPRSHSMRFIDKTSALSPWTKYEYRVL 2701
+ V +PRS + + L YE+RV+
Sbjct: 1943 DEGLWDMFVKDIPRS-ATSYTLSLDKLRQGVTYEFRVV 1979
Score = 61.2 bits (147), Expect = 3e-08
Identities = 125/537 (23%), Positives = 201/537 (37%), Gaps = 80/537 (14%)
Query: 1058 PPPRGQVQS--SSAINLSWSPPDSPNAHWLT--YSLLR---DGFEIYTTEDQYP--YSIQ 1108
PP Q ++ S+ I W+PP + + Y LL D E T P + +
Sbjct: 872 PPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVH 931
Query: 1109 YFLDTDLLPYTKY--SYYIETTNVHG--STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDS 1164
+ T+L +T Y S TT G ST + T + KPG G+L+ + I+ S
Sbjct: 932 HGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLVWTQEDKPGAV-GHLSFTEIL---DTS 987
Query: 1165 VTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSAT--IWNLVPFAKYDFSVQA 1222
+ ++W ++G I Y +S +++ + T+ I L Y V A
Sbjct: 988 LKVSWQEPLEKNGIITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAA 1047
Query: 1223 CTSGGCLHSLPITVTTAQAPPQRLSPPKM--QKISSTELHVEWSPPAELNGIIIRYELYM 1280
T+ G T+++ P +P + IS +++ P + I R+ +
Sbjct: 1048 VTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIV-- 1105
Query: 1281 RRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVL 1340
+ + W++ + E NE P M I L PYT Y FR+
Sbjct: 1106 ---------EGQVGAIGDEEEWVTLY---EEENE----PDAQMLEIPNLTPYTHYRFRMK 1149
Query: 1341 AVNMAGSVSSAWVSERTGES--APVFMIPPSVF--PLSSYSLNISWEKPADNVTRG--KV 1394
VN+ G S S R ++ AP + P SV S SL + W D+ G +
Sbjct: 1150 QVNIVGP-SPYSPSSRVIQTLQAPPDVAPTSVTVRTASETSLRLRWVPLPDSQYNGNPES 1208
Query: 1395 VGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGC-V 1453
VGY I ++ S L E +T+E L+ + YE + N+VG
Sbjct: 1209 VGYRIKYWRSDLQSSAVAQVVSDRL------EREFTIEELEEWMEYELQMQAFNAVGAGP 1262
Query: 1454 TSASGAGQTLAAAPAQLRPPL-VKGINSTTIHLKW--FPPEELNG--------------- 1495
S G+T + P+ + + ++ST I L W P ++ NG
Sbjct: 1263 WSEVVRGRTRESVPSAAPENVSAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLD 1322
Query: 1496 PSPIYQLERRESSLPALMTTMMKGIRF---------IGNGYCKFPSSTHPVNTDFTG 1543
P P + R + AL+ + K + + IGNG P D G
Sbjct: 1323 PEPRSHIVRGNHTQSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPG 1379
Score = 58.9 bits (141), Expect = 1e-07
Identities = 114/464 (24%), Positives = 170/464 (36%), Gaps = 71/464 (15%)
Query: 1059 PPRGQVQS---SSAINLSWSPPDSPN------AHWLTYSLLRDGFEIYTTEDQYPYSIQY 1109
PP+ V S + +I + W PP + L Y L E P + Y
Sbjct: 771 PPKNIVASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSP-EVNY 829
Query: 1110 FLDTDLLPYTKYSYYIETTNVHG-STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLT 1168
L TDL+ +T+Y + N G S AVT T GVP + S ++
Sbjct: 830 CLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFL 889
Query: 1169 WTTLSNQ--SGPIEKYILSC----APLAGGQPCVSYEGHETS-ATIWNLVPFAKYDFSVQ 1221
W Q +G + Y L AP A ++ + H I NL F Y SV
Sbjct: 890 WNPPPQQFINGINQGYKLLAWPADAPEAVTVVTIAPDFHGVHHGHITNLKKFTAYFTSVL 949
Query: 1222 ACTS-GGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGII----IRY 1276
T+ G S P V T + P + +I T L V W P E NGII I +
Sbjct: 950 CFTTPGDGPPSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISW 1009
Query: 1277 ELYMR---RLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYT 1333
E+Y R RL T +T+ E + I GL T
Sbjct: 1010 EVYGRNDSRLTHTLNSTTHEYK------------------------------IQGLSSLT 1039
Query: 1334 KYEFRVLAVNMAGS--VSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPADNVTR 1391
Y V AV G+ V+S+ +S P + +S S + + D T
Sbjct: 1040 TYTIDVAAVTAVGTGLVTSSTISSGVPPDLPGAPSNLVISNISPRSATLQFRPGYDGKTS 1099
Query: 1392 GK--VVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNS 1449
+V + + ++ ++ + + + A+ E + L PY Y F + N
Sbjct: 1100 ISRWIVEGQVGAIGDE--EEWVTLYEEENEPDAQMLE----IPNLTPYTHYRFRMKQVNI 1153
Query: 1450 VG--CVTSASGAGQTLAAAPAQLRPP--LVKGINSTTIHLKWFP 1489
VG + +S QTL AP + P V+ + T++ L+W P
Sbjct: 1154 VGPSPYSPSSRVIQTL-QAPPDVAPTSVTVRTASETSLRLRWVP 1196
Score = 55.8 bits (133), Expect = 1e-06
Identities = 59/218 (27%), Positives = 94/218 (43%), Gaps = 39/218 (17%)
Query: 1319 PPQTMTTITGLEPYTKYEFRVLAVNMAGSVSSAWVSERTGESAPVFM--IPPSVFP---- 1372
P T T++GL P Y+FRV AVN G + + E++ + + PPS P
Sbjct: 723 PEMTGVTVSGLTPARTYQFRVCAVNEVGR------GQYSAETSRLMLPEEPPSAPPKNIV 776
Query: 1373 ---LSSYSLNISWEKPAD----NVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQ 1425
++ S+ + W+ P + V RG ++ Y + L + Q++I S
Sbjct: 777 ASGRTNQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNI-----------TSP 825
Query: 1426 ELSY-TVEGLKPYRIYEFTITLCNSVGC-VTSASGAGQTLAAAPAQLRPP---LVKGINS 1480
E++Y V L + YE + N G V S + TL P PP + +NS
Sbjct: 826 EVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTLQGVPT--APPQNVQTEAVNS 883
Query: 1481 TTIHLKWFPPEE--LNGPSPIYQLERRESSLPALMTTM 1516
TTI W PP + +NG + Y+L + P +T +
Sbjct: 884 TTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVV 921
Score = 38.1 bits (87), Expect = 0.23
Identities = 101/458 (22%), Positives = 161/458 (35%), Gaps = 61/458 (13%)
Query: 1113 TDLLPYTKYSYYIETTNVHG-STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTT 1171
T L Y +Y + N+ G S S V P + P+ + + +TW
Sbjct: 1665 THLKKYRRYEVIMTAYNIIGESPASAPVEVFVGEAAPAMAPQNVQVTPLTASQLEVTWDP 1724
Query: 1172 L--SNQSGPIEKYILSCAPLAGGQPCVSYEG---HETSATIWNLVPFAKYDFSVQACTSG 1226
+Q+G I+ Y + + E + NL KY S+ A +
Sbjct: 1725 PPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAA 1784
Query: 1227 GC-LHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRS 1285
G S P T QA P S +I+ST L+V W PA NGI+ Y + L +
Sbjct: 1785 GDGPKSDPQQGRTHQAAPGAPSFLAFSEITSTTLNVSWGEPAAANGILQGYRVVYEPL-A 1843
Query: 1286 TKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMA 1345
+ S+ V W Q + L Y FRV A +
Sbjct: 1844 PVQGVSKVVTVEVRGNW------------------QRWLKVRDLTKGVTYFFRVQARTIT 1885
Query: 1346 -GSVSSAWVSERTGESAPVFMIPPSVFPLSSYS-LNISWEK--PADNVTRGKVVGYDINM 1401
G A ++ E +P P V S S L + W + D T G V+
Sbjct: 1886 YGPELQANITAGPAEGSP--GSPRDVLVTKSASELTLQWTEGHSGDTPTTGYVIE----- 1938
Query: 1402 LSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQ 1461
+ S + M + +A S LS ++ L+ YEF + N G ++ +
Sbjct: 1939 -ARPSDEGLWDMFVKDIPRSATSYTLS--LDKLRQGVTYEFRVVAVNEAGYGEPSNPS-- 1993
Query: 1462 TLAAAPAQLRPP--------LVKGINSTTIHLKWFPPEELNGPSPIYQLERRESSLPALM 1513
A AQ+ P LV ++S + L L+G + Y + S +
Sbjct: 1994 --TAVSAQVEAPFYEEWWFLLVMALSSLIVILLVVFALVLHGQNKKY----KNCSTGKGI 2047
Query: 1514 TTMMKGIRFIGNGYCKFPSSTHPVNTDFTGIKASFRTK 1551
+TM + + G+ S+ +N +K++F K
Sbjct: 2048 STMEESVTLDNGGFAALELSSRHLN-----VKSTFSKK 2080
>gi|5453810 netrin 3 [Homo sapiens]
Length = 580
Score = 163 bits (412), Expect = 5e-39
Identities = 97/321 (30%), Positives = 151/321 (47%), Gaps = 23/321 (7%)
Query: 369 VTISVDLENGQYQVFYIIIQFFSPQPTEIRIQRKKENSLDWEDWQYFARNC----GAFGM 424
VT++V L +++ ++ ++F S P + + + +++ W +F+ +C G
Sbjct: 105 VTLTVPLGKA-FELVFVSLRFCSAPPASVALLKSQDHGRSWAPLGFFSSHCDLDYGRLPA 163
Query: 425 KNNGDLEKPDSVNCLQLSNFTPYSRGNVTFSILTPGPNYRPGYNNFYNTPSLQEFVKATQ 484
NG C P G + FS+ P PG + ++P LQ++V AT
Sbjct: 164 PANGPAGPGPEALCFPAPLAQPDGSGLLAFSMQDSSP---PGLD-LDSSPVLQDWVTATD 219
Query: 485 IRFHFH-----GQYYTTETAVNLRHRYYAVDEITISGRCQCHGHADNCDTTSQPYRCLCS 539
+R G E V YA ++ + GRC+C+GHA C +Q + +C
Sbjct: 220 VRVVLTRPSTAGDPRDMEAVVPYS---YAATDLQVGGRCKCNGHASRCLLDTQGH-LICD 275
Query: 540 QESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFR 599
TEG C RC P Y D+P+++ + C C CN H++ C +N+ + R
Sbjct: 276 CRHGTEGPDCGRCKPFYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSG---R 332
Query: 600 GGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIG 659
GGVC +C HNT GR+C C++ F+R G S C+ CDC VG + C+Q
Sbjct: 333 RSGGVCLNCRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAAGKT--CNQTT 390
Query: 660 GQCNCKRHVSGRQCNQCQNGF 680
GQC CK V+G CN+C GF
Sbjct: 391 GQCPCKDGVTGLTCNRCAPGF 411
Score = 85.5 bits (210), Expect = 1e-15
Identities = 53/176 (30%), Positives = 77/176 (43%), Gaps = 26/176 (14%)
Query: 575 CQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSA 634
C+CN H+ C + G + DC H T G +C CK ++ + +A
Sbjct: 255 CKCNGHASRCLLDTQ------------GHLICDCRHGTEGPDCGRCKPFYCDRPWQRATA 302
Query: 635 ID--VCKPCDCDTVGTRNG------SILCDQIGGQC-NCKRHVSGRQCNQCQNGFYN--- 682
+ C C C+ R + + GG C NC+ + +GR C+ C+ GFY
Sbjct: 303 RESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCREGFYRDPG 362
Query: 683 LQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRS 738
D C C+C+ G TC+Q +GQC CK V GL C+ C GF+ RS
Sbjct: 363 RALSDRRACRACDCHPVGAAGK--TCNQTTGQCPCKDGVTGLTCNRCAPGFQQSRS 416
Score = 77.4 bits (189), Expect = 3e-13
Identities = 52/165 (31%), Positives = 68/165 (41%), Gaps = 37/165 (22%)
Query: 747 CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDTCRENFY---------GLDVTNCKACDC 797
C+CN H S C+C+ +G C C+ FY + C AC C
Sbjct: 255 CKCNGHASRCLLDTQGHLICDCRHGTEGPDCGRCKP-FYCDRPWQRATARESHACLACSC 313
Query: 798 D--------------TAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSF- 842
+ +G G VC C+ N GR C+ C EG FY +
Sbjct: 314 NGHARRCRFNMELYRLSGRRSGGVC------LNCRHNTAGRHCHYCREG-FYRDPGRALS 366
Query: 843 ---LCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEP 884
C C+C G + CN++TGQCPCK GVTGL CN+C P
Sbjct: 367 DRRACRACDCHPVGAAGKT--CNQTTGQCPCKDGVTGLTCNRCAP 409
Score = 75.1 bits (183), Expect = 2e-12
Identities = 58/191 (30%), Positives = 73/191 (38%), Gaps = 45/191 (23%)
Query: 657 QIGGQCNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCK 716
Q+GG+C C H S +C LD G C+C GT D G+CK
Sbjct: 250 QVGGRCKCNGHAS-----RCL--------LDTQGHLICDCR-HGTEGPDC------GRCK 289
Query: 717 CKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFC--------NPHSGQC-E 767
+C+ ++ + C C CN H +F G C
Sbjct: 290 PF---------YCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGRRSGGVCLN 340
Query: 768 CKKEAKGLQCDTCRENFYG------LDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNV 821
C+ G C CRE FY D C+ACDC G+ G CN TGQC CK V
Sbjct: 341 CRHNTAGRHCHYCREGFYRDPGRALSDRRACRACDCHPVGAA-GKTCNQTTGQCPCKDGV 399
Query: 822 EGRQCNKCLEG 832
G CN+C G
Sbjct: 400 TGLTCNRCAPG 410
Score = 74.7 bits (182), Expect = 2e-12
Identities = 56/184 (30%), Positives = 76/184 (41%), Gaps = 35/184 (19%)
Query: 896 HCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNAT------GCL 949
H C D+ G L ICD C +G C +C+P + P CL
Sbjct: 260 HASRCLLDTQGHL---ICD-------CRHGTEGPDCGRCKPFYCDRPWQRATARESHACL 309
Query: 950 PCSCHTTGA---VNHICNSLTGQ-----CVCQDASIAGQRCDQCKDHYFGFDPQTGR--- 998
CSC+ N L+G+ C+ + AG+ C C++ GF GR
Sbjct: 310 ACSCNGHARRCRFNMELYRLSGRRSGGVCLNCRHNTAGRHCHYCRE---GFYRDPGRALS 366
Query: 999 ----CQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTP 1054
C+ C+CH GA +TC+ TGQC CK VTG C+ C P + + C KTP
Sbjct: 367 DRRACRACDCHPVGAAGKTCNQTTGQCPCKDGVTGLTCNRCAPGFQQ-SRSPVAPCVKTP 425
Query: 1055 FQQP 1058
P
Sbjct: 426 IPGP 429
Score = 62.8 bits (151), Expect = 9e-09
Identities = 39/144 (27%), Positives = 56/144 (38%), Gaps = 27/144 (18%)
Query: 662 CNCKRHVSGRQCNQCQNGFY------NLQELDPDGCSPCNCNTSGTVDG------DITCH 709
C+C+ G C +C+ FY + C C+CN ++
Sbjct: 274 CDCRHGTEGPDCGRCKP-FYCDRPWQRATARESHACLACSCNGHARRCRFNMELYRLSGR 332
Query: 710 QNSGQC-KCKANVIGLRCDHCNFGFKFLRSFNDVG--------CEPCQCNLHGSVNKFCN 760
++ G C C+ N G C +C GF + D G C C C+ G+ K CN
Sbjct: 333 RSGGVCLNCRHNTAGRHCHYCREGF-----YRDPGRALSDRRACRACDCHPVGAAGKTCN 387
Query: 761 PHSGQCECKKEAKGLQCDTCRENF 784
+GQC CK GL C+ C F
Sbjct: 388 QTTGQCPCKDGVTGLTCNRCAPGF 411
>gi|122937440 multiple EGF-like-domains 9 [Homo sapiens]
Length = 639
Score = 162 bits (411), Expect = 6e-39
Identities = 105/314 (33%), Positives = 154/314 (49%), Gaps = 24/314 (7%)
Query: 795 CDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGT 854
C+C GSL CN TGQC C+P +G C C EG FYL S LC PC+C G
Sbjct: 241 CNCSVVGSLNVNRCNQTTGQCECRPGYQGLHCETCKEG-FYLNY-TSGLCQPCDCSPHGA 298
Query: 855 INGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICD 914
+ S+ CN S+G+C CK+GV G C++C+ Y + + C C+C++ CD
Sbjct: 299 L--SIPCN-SSGKCQCKVGVIGSICDRCQDGYYGFSKNG---CLPCQCNN----RSASCD 348
Query: 915 PISGQCL-CVPNRQGRRCNQCQPGFYISPGNATGCLPCSCH---TTGAVNHICNSLTGQC 970
++G CL C N +G C +C+ GFY SP CL C C +TG+ + + L +C
Sbjct: 349 ALTGACLNCQENSKGNHCEECKEGFYQSPDATKECLRCPCSAVTSTGSCSIKSSELEPEC 408
Query: 971 -VCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALN-ETCHLVTGQCF-CKQFV 1027
C+D I G C++C++ Y+ FD +CQ C+ H+ + C +G+C C
Sbjct: 409 DQCKDGYI-GPNCNKCENGYYNFDSICRKCQ-CHGHVDPVKTPKICKPESGECINCLHNT 466
Query: 1028 TGSKCDACVPSASHLDVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTY 1087
TG C+ C+ H D+ C K P P G S +L+ S P T
Sbjct: 467 TGFWCENCLEGYVH-DLEG--NCIKKEVILPTPEGSTILVSNASLTTSVPTPVINSTFTP 523
Query: 1088 SLLRDGFEIYTTED 1101
+ L+ F + T+E+
Sbjct: 524 TTLQTIFSVSTSEN 537
Score = 152 bits (384), Expect = 8e-36
Identities = 87/253 (34%), Positives = 131/253 (51%), Gaps = 23/253 (9%)
Query: 694 CNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHG 753
CNC+ G+++ + C+Q +GQC+C+ GL C+ C GF ++ C+PC C+ HG
Sbjct: 241 CNCSVVGSLNVN-RCNQTTGQCECRPGYQGLHCETCKEGFYL--NYTSGLCQPCDCSPHG 297
Query: 754 SVNKFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTG 813
+++ CN SG+C+CK G CD C++ +YG C C C+ + C+A TG
Sbjct: 298 ALSIPCN-SSGKCQCKVGVIGSICDRCQDGYYGFSKNGCLPCQCNNRSA----SCDALTG 352
Query: 814 QCI-CKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDK-TGTINGSLLCNKSTGQC-PC 870
C+ C+ N +G C +C EG FY + + CL C C T T + S+ ++ +C C
Sbjct: 353 ACLNCQENSKGNHCEECKEG-FYQSPDATKECLRCPCSAVTSTGSCSIKSSELEPECDQC 411
Query: 871 KLGVTGLRCNQCEPHRYNLTIDNFQHCQMCEC----DSLGTLPGTICDPISGQCL-CVPN 925
K G G CN+CE YN C+ C+C D + T IC P SG+C+ C+ N
Sbjct: 412 KDGYIGPNCNKCENGYYNFD----SICRKCQCHGHVDPVKT--PKICKPESGECINCLHN 465
Query: 926 RQGRRCNQCQPGF 938
G C C G+
Sbjct: 466 TTGFWCENCLEGY 478
Score = 134 bits (338), Expect = 2e-30
Identities = 89/285 (31%), Positives = 126/285 (44%), Gaps = 31/285 (10%)
Query: 608 CEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRH 667
CE N + L + +V A+ C+C VG+ N + C+Q GQC C+
Sbjct: 211 CESNLKSKYLPLTQPVMNLRVS---EAVKTEYVCNCSVVGSLNVN-RCNQTTGQCECRPG 266
Query: 668 VSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCD 727
G C C+ GFY C PC+C+ G + I C+ +SG+C+CK VIG CD
Sbjct: 267 YQGLHCETCKEGFY--LNYTSGLCQPCDCSPHGAL--SIPCN-SSGKCQCKVGVIGSICD 321
Query: 728 HCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQC-ECKKEAKGLQCDTCRENFY- 785
C G+ F+ GC PCQCN + + C+ +G C C++ +KG C+ C+E FY
Sbjct: 322 RCQDGY---YGFSKNGCLPCQCN---NRSASCDALTGACLNCQENSKGNHCEECKEGFYQ 375
Query: 786 GLDVT-NCKACDCDTAGSLPGTVCNAKTGQC-----ICKPNVEGRQCNKCLEGNFYLRQN 839
D T C C C S C+ K+ + CK G CNKC G + N
Sbjct: 376 SPDATKECLRCPCSAVTSTGS--CSIKSSELEPECDQCKDGYIGPNCNKCENGYY----N 429
Query: 840 NSFLCLPCNC-DKTGTINGSLLCNKSTGQC-PCKLGVTGLRCNQC 882
+C C C + +C +G+C C TG C C
Sbjct: 430 FDSICRKCQCHGHVDPVKTPKICKPESGECINCLHNTTGFWCENC 474
Score = 127 bits (318), Expect = 4e-28
Identities = 84/256 (32%), Positives = 127/256 (49%), Gaps = 31/256 (12%)
Query: 747 CQCNLHGSVN-KFCNPHSGQCECKKEAKGLQCDTCRENFYGLDVTN--CKACDCDTAGSL 803
C C++ GS+N CN +GQCEC+ +GL C+TC+E FY L+ T+ C+ CDC G+L
Sbjct: 241 CNCSVVGSLNVNRCNQTTGQCECRPGYQGLHCETCKEGFY-LNYTSGLCQPCDCSPHGAL 299
Query: 804 PGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNK 863
CN+ +G+C CK V G C++C +G + +N CLPC C+ N S C+
Sbjct: 300 -SIPCNS-SGKCQCKVGVIGSICDRCQDGYYGFSKNG---CLPCQCN-----NRSASCDA 349
Query: 864 STGQC-PCKLGVTGLRCNQCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI---CDPISGQ 919
TG C C+ G C +C+ Y + D + C C C ++ T G+ + +
Sbjct: 350 LTGACLNCQENSKGNHCEECKEGFYQ-SPDATKECLRCPCSAV-TSTGSCSIKSSELEPE 407
Query: 920 C-LCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVN-----HICNSLTGQCVCQ 973
C C G CN+C+ G+Y + C C CH G V+ IC +G+C+
Sbjct: 408 CDQCKDGYIGPNCNKCENGYY---NFDSICRKCQCH--GHVDPVKTPKICKPESGECINC 462
Query: 974 DASIAGQRCDQCKDHY 989
+ G C+ C + Y
Sbjct: 463 LHNTTGFWCENCLEGY 478
Score = 112 bits (280), Expect = 1e-23
Identities = 76/247 (30%), Positives = 109/247 (44%), Gaps = 29/247 (11%)
Query: 603 GVCDDCEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQC 662
G C+ C G +CE CK+ F+ + +C+PCDC G SI C+ G+C
Sbjct: 259 GQCE-CRPGYQGLHCETCKEGFYLNYTS-----GLCQPCDCSPHGAL--SIPCNS-SGKC 309
Query: 663 NCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQC-KCKANV 721
CK V G C++CQ+G+Y + +GC PC CN +C +G C C+ N
Sbjct: 310 QCKVGVIGSICDRCQDGYYGFSK---NGCLPCQCNNRSA-----SCDALTGACLNCQENS 361
Query: 722 IGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCE-----CKKEAKGLQ 776
G C+ C GF + C C C+ S C+ S + E CK G
Sbjct: 362 KGNHCEECKEGF-YQSPDATKECLRCPCSAVTSTGS-CSIKSSELEPECDQCKDGYIGPN 419
Query: 777 CDTCRENFYGLDVTNCKACDCDTAGSLPGT--VCNAKTGQCI-CKPNVEGRQCNKCLEGN 833
C+ C +Y D + C+ C C T +C ++G+CI C N G C CLEG
Sbjct: 420 CNKCENGYYNFD-SICRKCQCHGHVDPVKTPKICKPESGECINCLHNTTGFWCENCLEGY 478
Query: 834 FYLRQNN 840
+ + N
Sbjct: 479 VHDLEGN 485
Score = 100 bits (250), Expect = 3e-20
Identities = 50/138 (36%), Positives = 75/138 (54%), Gaps = 9/138 (6%)
Query: 899 MCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGA 958
+C C +G+L C+ +GQC C P QG C C+ GFY++ + C PC C GA
Sbjct: 240 VCNCSVVGSLNVNRCNQTTGQCECRPGYQGLHCETCKEGFYLNYTSGL-CQPCDCSPHGA 298
Query: 959 VNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVT 1018
++ CNS +G+C C+ + G CD+C+D Y+GF C PC C+ A +C +T
Sbjct: 299 LSIPCNS-SGKCQCK-VGVIGSICDRCQDGYYGF--SKNGCLPCQCNNRSA---SCDALT 351
Query: 1019 GQCF-CKQFVTGSKCDAC 1035
G C C++ G+ C+ C
Sbjct: 352 GACLNCQENSKGNHCEEC 369
Score = 98.2 bits (243), Expect = 2e-19
Identities = 69/225 (30%), Positives = 94/225 (41%), Gaps = 46/225 (20%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFN---CKP 574
C C H + +C C G CDRC D Y F+ C P
Sbjct: 291 CDCSPHGALSIPCNSSGKCQCKVGVI--GSICDRCQ-----------DGYYGFSKNGCLP 337
Query: 575 CQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDYFFRQVGADPSA 634
CQCN+ S SC G C +C+ N+ G +CE CK+ F++ P A
Sbjct: 338 CQCNNRSASCDALT--------------GACLNCQENSKGNHCEECKEGFYQ----SPDA 379
Query: 635 IDVCKPCDCDTV-GTRNGSILCDQIGGQCN-CKRHVSGRQCNQCQNGFYNLQELDPDGCS 692
C C C V T + SI ++ +C+ CK G CN+C+NG+YN + C
Sbjct: 380 TKECLRCPCSAVTSTGSCSIKSSELEPECDQCKDGYIGPNCNKCENGYYNFDSI----CR 435
Query: 693 PCNCNTSGTVDGDIT---CHQNSGQC-KCKANVIGLRCDHCNFGF 733
C C+ G VD T C SG+C C N G C++C G+
Sbjct: 436 KCQCH--GHVDPVKTPKICKPESGECINCLHNTTGFWCENCLEGY 478
Score = 96.7 bits (239), Expect = 5e-19
Identities = 72/253 (28%), Positives = 108/253 (42%), Gaps = 55/253 (21%)
Query: 545 EGLHCDRCLPLYNDKPFRQGDQVYAFN--CKPCQCNSHSKSCHYNISVDPFPFEHFRGGG 602
+GLHC+ C ++G + + C+PC C+ H +S+
Sbjct: 268 QGLHCETC---------KEGFYLNYTSGLCQPCDCSPHGA-----LSIP-------CNSS 306
Query: 603 GVCDDCEHNTTGRNCELCKD--YFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGG 660
G C C+ G C+ C+D Y F + G C PC C+ N S CD + G
Sbjct: 307 GKC-QCKVGVIGSICDRCQDGYYGFSKNG--------CLPCQCN-----NRSASCDALTG 352
Query: 661 QC-NCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCN-TSGTVDGDITCHQNSGQC-KC 717
C NC+ + G C +C+ GFY + + C C C+ + T I + +C +C
Sbjct: 353 ACLNCQENSKGNHCEECKEGFYQSPDATKE-CLRCPCSAVTSTGSCSIKSSELEPECDQC 411
Query: 718 KANVIGLRCDHCNFGFKFLRSFNDVGCEPCQCNLHGSVN-----KFCNPHSGQC-ECKKE 771
K IG C+ C G+ +F+ + C CQC HG V+ K C P SG+C C
Sbjct: 412 KDGYIGPNCNKCENGY---YNFDSI-CRKCQC--HGHVDPVKTPKICKPESGECINCLHN 465
Query: 772 AKGLQCDTCRENF 784
G C+ C E +
Sbjct: 466 TTGFWCENCLEGY 478
Score = 33.1 bits (74), Expect = 7.4
Identities = 21/59 (35%), Positives = 25/59 (42%), Gaps = 15/59 (25%)
Query: 506 YYAVDEITISGRCQCHGHADNCDTTSQPYRCLCSQES--------FTEGLHCDRCLPLY 556
YY D +I +CQCHGH D T +C ES T G C+ CL Y
Sbjct: 427 YYNFD--SICRKCQCHGHVDPVKTPK-----ICKPESGECINCLHNTTGFWCENCLEGY 478
>gi|181336739 multiple EGF-like-domains 11 [Homo sapiens]
Length = 1044
Score = 155 bits (392), Expect = 1e-36
Identities = 155/573 (27%), Positives = 206/573 (35%), Gaps = 118/573 (20%)
Query: 515 SGRCQCHGHADNCDTTSQPYRC-------LCSQESFTEGLHCDRCL---PLYNDKPFRQG 564
S C CH + C T+ C C + EGLH C P D
Sbjct: 315 SQHCDCH-NGGQCSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLPCPCDADNTISCH 373
Query: 565 DQVYAFNCKPCQCNSH-SKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCELCKDY 623
A C+P H ++SC D G C H+ TG C C
Sbjct: 374 PVTGACTCQPGWSGHHCNESCPVGYYGDGCQLPCTCQNGADC----HSITG-GCT-CAPG 427
Query: 624 FFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCN-QCQNGFYN 682
F +V A A P +C ++ + N C + G C CK G C C +G +
Sbjct: 428 FMGEVCAVSCAAGTYGP-NCSSICSCNNGGTCSPVDGSCTCKEGWQGLDCTLPCPSGTWG 486
Query: 683 LQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCD-HCNFGFKFLRSFND 741
L NCN S T C G C C +G C+ C G +F
Sbjct: 487 L-----------NCNESCTCANGAACSPIDGSCSCTPGWLGDTCELPCPDG-----TFGL 530
Query: 742 VGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCD-TCRENFYGLDVTNCK-ACDCDT 799
E C C+ C+P +G C C G++CD TC +G NC +C C+
Sbjct: 531 NCSEHCDCSHADG----CDPVTGHCCCLAGWTGIRCDSTCPPGRWG---PNCSVSCSCEN 583
Query: 800 AGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTINGSL 859
GS C+ + G C C P G C + FY PC ++ S
Sbjct: 584 GGS-----CSPEDGSCECAPGFRGPLCQRICPPGFY----GHGCAQPCPL----CVHSSR 630
Query: 860 LCNKSTGQCPCKLGVTGLRCNQ-CEPHRYNLTIDNFQHC-QMCECDSLGTLPGTICDPIS 917
C+ +G C C G +G CNQ C + Q C Q+C C + GT C PI
Sbjct: 631 PCHHISGICECLPGFSGALCNQVCAGGYFG------QDCAQLCSCANNGT-----CSPID 679
Query: 918 GQCLCVPNRQGRRCNQ-CQPGFY-------ISPGNATGCLP--CSCHTTGAVNHI----- 962
G C C P G+ C+Q C PGF+ S N C +CH T +
Sbjct: 680 GSCQCFPGWIGKDCSQACPPGFWGPACFHACSCHNGASCSAEDGACHCTPGWTGLFCTQR 739
Query: 963 ---------------------CNSLTGQCVCQDASIAGQRCDQ-CKDHYFGFDPQTGRCQ 1000
C+ ++G+C C+ GQ C+Q C FG+ Q Q
Sbjct: 740 CPAAFFGKDCGRVCQCQNGASCDHISGKCTCR-TGFTGQHCEQRCAPGTFGYGCQ----Q 794
Query: 1001 PCNCHLSGALNETCHLVTGQCFCKQFVTGSKCD 1033
C C N TC VTG C+C G +CD
Sbjct: 795 LCEC----MNNSTCDHVTGTCYCSPGFKGIRCD 823
Score = 148 bits (373), Expect = 2e-34
Identities = 160/567 (28%), Positives = 205/567 (36%), Gaps = 143/567 (25%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCKPCQC 577
C CH H CD + C T G DRC + PF + F QC
Sbjct: 275 CPCH-HGGQCDHVTGQCHC-------TAGYMGDRC---QEECPFGS----FGF-----QC 314
Query: 578 NSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCE--LCKDYFFRQVGADPSAI 635
+ H CH P G C+ CE G C+ LC + G
Sbjct: 315 SQHC-DCHNGGQCSPTT--------GACE-CEPGYKGPRCQERLCPE------GLHGPGC 358
Query: 636 DVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQ-CQNGFYNLQELDPDGCS-P 693
+ PCD D +I C + G C C+ SG CN+ C G+Y DGC P
Sbjct: 359 TLPCPCDADN------TISCHPVTGACTCQPGWSGHHCNESCPVGYYG------DGCQLP 406
Query: 694 CNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCD-HCNFGFKFLRSFNDVGCEPCQCNLH 752
C C CH +G C C +G C C G ++ C CN
Sbjct: 407 CTCQNGAD------CHSITGGCTCAPGFMGEVCAVSCAAG-----TYGPNCSSICSCNNG 455
Query: 753 GSVNKFCNPHSGQCECKKEAKGLQCDT-CRENFYGLDVTNC-KACDCDTAGSLPGTVCNA 810
G+ C+P G C CK+ +GL C C +GL NC ++C C G C+
Sbjct: 456 GT----CSPVDGSCTCKEGWQGLDCTLPCPSGTWGL---NCNESCTCAN-----GAACSP 503
Query: 811 KTGQCICKPNVEGRQCN-KCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCP 869
G C C P G C C +G F L + C+C C+ TG C
Sbjct: 504 IDGSCSCTPGWLGDTCELPCPDGTFGLNCSEH-----CDCSHADG------CDPVTGHCC 552
Query: 870 CKLGVTGLRCNQ-CEPHRY------NLTIDNFQHCQ----MCECDS--LGTLPGTICDP- 915
C G TG+RC+ C P R+ + + +N C CEC G L IC P
Sbjct: 553 CLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQRICPPG 612
Query: 916 ----------------------ISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSC 953
ISG C C+P G CNQ G Y A CSC
Sbjct: 613 FYGHGCAQPCPLCVHSSRPCHHISGICECLPGFSGALCNQVCAGGYFGQDCAQ---LCSC 669
Query: 954 HTTGAVNHICNSLTGQCVCQDASIAGQRCDQ-CKDHYFGFDPQTGRCQPCNCHLSGALNE 1012
A N C+ + G C C I G+ C Q C ++G C+CH +GA
Sbjct: 670 ----ANNGTCSPIDGSCQCFPGWI-GKDCSQACPPGFWG----PACFHACSCH-NGA--- 716
Query: 1013 TCHLVTGQCFCKQFVTGSKCDACVPSA 1039
+C G C C TG C P+A
Sbjct: 717 SCSAEDGACHCTPGWTGLFCTQRCPAA 743
Score = 128 bits (322), Expect = 1e-28
Identities = 126/439 (28%), Positives = 170/439 (38%), Gaps = 93/439 (21%)
Query: 636 DVCKPCDCDTVGT--------RNGSILCDQIGGQCNCKRHVSGRQCNQ-CQNGFYNLQEL 686
D CD D G +NG+ LC+ I G C C G +C + C G +
Sbjct: 128 DCSSGCDSDHWGPHCSNRCQCQNGA-LCNPITGACVCAAGFRGWRCEELCAPGTHG---- 182
Query: 687 DPDGCS-PCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDH-CNFGFKFLRSFNDVGC 744
GC PC C + C +G+C C G+ C+ C G + C
Sbjct: 183 --KGCQLPCQCRHGAS------CDPRAGECLCAPGYTGVYCEELCPPGS------HGAHC 228
Query: 745 E-PCQCNLHGSVNKFCNPHSGQCECKKEAKGLQC-DTCRENFYGLDVTNCKA-CDCDTAG 801
E C C G+ C+ +G+C C G C C +G NC C C G
Sbjct: 229 ELRCPCQNGGT----CHHITGECACPPGWTGAVCAQPCPPGTFG---QNCSQDCPCHHGG 281
Query: 802 SLPGTVCNAKTGQCICKPNVEGRQCNK-CLEGNFYLRQNNSFLCLP-CNCDKTGTINGSL 859
C+ TGQC C G +C + C G+F F C C+C G
Sbjct: 282 Q-----CDHVTGQCHCTAGYMGDRCQEECPFGSF------GFQCSQHCDCHNGGQ----- 325
Query: 860 LCNKSTGQCPCKLGVTGLRCNQ--CEP--HRYNLTIDNFQHCQMCECDSLGTLPGTICDP 915
C+ +TG C C+ G G RC + C H T+ C CD+ T+ C P
Sbjct: 326 -CSPTTGACECEPGYKGPRCQERLCPEGLHGPGCTLP-------CPCDADNTIS---CHP 374
Query: 916 ISGQCLCVPNRQGRRCNQ-CQPGFYISPGNATGC-LPCSCHTTGAVNHICNSLTGQCVCQ 973
++G C C P G CN+ C G+Y GC LPC+C GA C+S+TG C C
Sbjct: 375 VTGACTCQPGWSGHHCNESCPVGYY-----GDGCQLPCTCQ-NGA---DCHSITGGCTCA 425
Query: 974 DASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCD 1033
+ C +G P C+C+ G TC V G C CK+ G C
Sbjct: 426 PGFMGEVCAVSCAAGTYG--PNCSSI--CSCNNGG----TCSPVDGSCTCKEGWQGLDCT 477
Query: 1034 ACVPSAS-HLDVNNLLGCS 1051
PS + L+ N C+
Sbjct: 478 LPCPSGTWGLNCNESCTCA 496
Score = 108 bits (270), Expect = 1e-22
Identities = 110/415 (26%), Positives = 147/415 (35%), Gaps = 101/415 (24%)
Query: 565 DQVYAFNCKP-CQCNSHSKSCHYNISVDPFPFEH--FRGGGGV-CDD-CEHNTTGRNCEL 619
D + NC C C SH+ C DP G G+ CD C G NC +
Sbjct: 525 DGTFGLNCSEHCDC-SHADGC------DPVTGHCCCLAGWTGIRCDSTCPPGRWGPNCSV 577
Query: 620 CKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQ-CQN 678
C C+ G+ C G C C G C + C
Sbjct: 578 S--------------------CSCENGGS------CSPEDGSCECAPGFRGPLCQRICPP 611
Query: 679 GFYNLQELDPDGCS-PCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDH-CNFGFKFL 736
GFY GC+ PC V CH SG C+C G C+ C G+
Sbjct: 612 GFYG------HGCAQPCPL----CVHSSRPCHHISGICECLPGFSGALCNQVCAGGY--- 658
Query: 737 RSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCD-TCRENFYGLDVTNCKAC 795
F + C C +G+ C+P G C+C G C C F+G + AC
Sbjct: 659 --FGQDCAQLCSCANNGT----CSPIDGSCQCFPGWIGKDCSQACPPGFWGPACFH--AC 710
Query: 796 DCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTGTI 855
C S C+A+ G C C P G C + F+ + +C +
Sbjct: 711 SCHNGAS-----CSAEDGACHCTPGWTGLFCTQRCPAAFFGK----------DCGRVCQC 755
Query: 856 NGSLLCNKSTGQCPCKLGVTGLRCNQ-CEPHRYNLTIDNFQHCQMCECDSLGTLPGTICD 914
C+ +G+C C+ G TG C Q C P + Q+CEC + T CD
Sbjct: 756 QNGASCDHISGKCTCRTGFTGQHCEQRCAPGTFGYGCQ-----QLCECMNNST-----CD 805
Query: 915 PISGQCLCVPNRQGRRCNQC-------QPGFYISPGNATGCLPCSCHTTGAVNHI 962
++G C C P +G RC+Q P ISP L H+ GAV I
Sbjct: 806 HVTGTCYCSPGFKGIRCDQAALMMEELNPYTKISP-----ALGAERHSVGAVTGI 855
Score = 43.9 bits (102), Expect = 0.004
Identities = 42/151 (27%), Positives = 53/151 (35%), Gaps = 47/151 (31%)
Query: 929 RRCNQCQPGFYIS-------------------------------PGNATGC------LPC 951
RR +QC PG+Y S P ++GC C
Sbjct: 83 RRRSQCCPGYYESGDFCIPLCTEECVHGRCVSPDTCHCEPGWGGPDCSSGCDSDHWGPHC 142
Query: 952 SCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQ-CKDHYFGFDPQTGRCQPCNCHLSGAL 1010
S +CN +TG CVC A G RC++ C G G PC C GA
Sbjct: 143 SNRCQCQNGALCNPITGACVCA-AGFRGWRCEELCAPGTHG----KGCQLPCQCR-HGA- 195
Query: 1011 NETCHLVTGQCFCKQFVTGSKCDACVPSASH 1041
+C G+C C TG C+ P SH
Sbjct: 196 --SCDPRAGECLCAPGYTGVYCEELCPPGSH 224
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 149 bits (375), Expect = 9e-35
Identities = 204/801 (25%), Positives = 341/801 (42%), Gaps = 82/801 (10%)
Query: 3834 LTPFTQYEIRIQACQNGSCGVSSRMFV-----KTPEAAPMDLNSPVLKALGSACIEIKWM 3888
L+P++ YE R+ A N G S + + P +AP D+ + + L S I ++W
Sbjct: 383 LSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA---RMLSSTTILVQWK 439
Query: 3889 PPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSK 3948
PE+PNG I Y +Y + + + + G+ L P Y +V A S
Sbjct: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN-LVPQKTYSVKVLAFTSI 498
Query: 3949 GS---VESLWSLTQT-LEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQE 4004
G + +TQT + P +F A + S S+LL+WT P S I++Y +VY++
Sbjct: 499 GDGPLSSDIQVITQTGVPGQPLNFKA---EPESETSILLSWTPPRSDT--IANYELVYKD 553
Query: 4005 RPDDPTFNSPTVHAFTVK-GTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTL-IQTL 4062
T++ GTS++ L GL+P + Y + A + G S + +T+
Sbjct: 554 GEHGEE------QRITIEPGTSYR--LQGLKPNSLYYFRLAARSPQGLGASTAEISARTM 605
Query: 4063 ESSPSGLRNFIVEQKENGRALLLQWSEPM--RTNGVIKTYNIF-------SDGFLEYSGL 4113
+S PS I + ++L+ W P + NG+I Y+I D E G+
Sbjct: 606 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGI 665
Query: 4114 ---NRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPL--WTDEAPPDSQLAPTVHSVKS 4168
++L +L+ +T Y +T+ A T G + L ++ P V +V S
Sbjct: 666 PSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 725
Query: 4169 TSVELSWSEPVNPN---GKIIRYEV-IRRCFEGKAWGNQTIQ----ADEKIVFTEYNTER 4220
TSV++SW PV PN G+I Y+V R G+ G ++ AD + F + TE
Sbjct: 726 TSVKVSWRSPV-PNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDD-TTEH 783
Query: 4221 NTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSW-NVVRTLQAPPEGLSPPVISYVSMNPQ 4279
+ + +GLQP T + + + G S +V T A P G VI++ MN
Sbjct: 784 DMII---SGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVP-GKPRLVINHTQMNTA 839
Query: 4280 KLLISWIPPEQSNGIIQSYRLQ--RNEM--LYPFSFDPVTFNYTDEELLPFSTYSYALQA 4335
LI W PP + G +Q YRL+ R +M L F ++T ++ ++Y + L A
Sbjct: 840 --LIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA 897
Query: 4336 CTSGGCSTSKPTSITTLEAAPSEVSPPDLWA--VSATQMNVCWSPPTV--QNGKITKYLV 4391
G I+ E P+ P +L + ++T + + W PP + +NG ITKY +
Sbjct: 898 RNKVGFGEEMVKEISIPEEVPTGF-PQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTL 956
Query: 4392 RYDN--------KESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEAL 4443
Y + ++ + + ++ L+P + Y+ + A T+ G S S
Sbjct: 957 LYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKG-PGPYSPSVQFRTLP 1015
Query: 4444 PENMDSPTLQVTG--SESIEITWKPPRNPNGQIRSYELRRDGTIV--YTGLETRYRDFTL 4499
+ + + V S+ ++W+ P N N + L DG +V G T+ L
Sbjct: 1016 VDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNL 1075
Query: 4500 TPGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTN 4559
P YS+ +T + G L V +T+P +P + ++ P V N
Sbjct: 1076 KPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQLPEVPAN 1134
Query: 4560 GDIINYTLFIRELFERETKII 4580
+I Y + I L + K I
Sbjct: 1135 ENIKGYYIIIVPLKKSRGKFI 1155
Score = 144 bits (364), Expect = 2e-33
Identities = 195/781 (24%), Positives = 311/781 (39%), Gaps = 80/781 (10%)
Query: 3561 QEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWSV--PEKSNG 3618
Q +Y A + G + + T + +P+ P +T +A ++ L+W PE +
Sbjct: 296 QSANYTCVAMSTLGVIEA--IAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSY 353
Query: 3619 VIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGC-TSSEPFLGQTL 3677
I +++ + + D +++V GL PY++Y F + A + G SEP L QT
Sbjct: 354 YIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTS 413
Query: 3678 QAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQL-------SRNGNLLFLGGSE 3730
+ AP + +++STT+ + W PE+PNG + Y++ N + ++
Sbjct: 414 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 473
Query: 3731 EQNFTDKNLEPNSRYTYKLEVKTG-GGSSASDDYIVQTPMSTPEEIYPPYNITV--IGPY 3787
Q T NL P Y+ K+ T G S D V T P + P N
Sbjct: 474 SQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ---PLNFKAEPESET 530
Query: 3788 SIFVAWIPPGILIPEIPVEYNVLLNDGS-VTPLAFSVGHHQSTLLENLTPFTQYEIRIQA 3846
SI ++W PP + Y ++ DG ++ S L+ L P + Y R+ A
Sbjct: 531 SILLSWTPPR---SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 587
Query: 3847 CQNGSCG-----VSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPP--EKPNGIIIN 3899
G +S+R P A P D++ + S I + W PP EK NGII
Sbjct: 588 RSPQGLGASTAEISARTMQSKPSAPPQDIS---CTSPSSTSILVSWQPPPVEKQNGIITE 644
Query: 3900 YFIYRRPAGIEEE---SVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKG-SVESLW 3955
Y I E++ +L + S+ +++ L +T Y V A G ESL
Sbjct: 645 YSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQ---LEKWTEYRITVTAHTDVGPGPESLS 701
Query: 3956 SLTQTLEAPPQDFPAP-WAQATSAHSVLLNWTK--PESPNGIISHYRVVYQERPDDPTFN 4012
L +T E P P +A ++ SV ++W P +G I Y+V Y +
Sbjct: 702 VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKG 761
Query: 4013 SPTVHAFTVKG--------TSHQAHLYGLEPFTTYRIGVVAANHAGE-ILSPWTLIQTLE 4063
P + + T H + GL+P T+Y + V A G+ S L+ T
Sbjct: 762 QPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 821
Query: 4064 SSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSD-------GFLEYSGLNRQ 4116
+ P R I + N L+QW P+ T G ++ Y + LE+S
Sbjct: 822 AVPGKPRLVINHTQMN--TALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDH 879
Query: 4117 FLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHS--VKSTSVELS 4174
F + Y L A + G + + E P + +HS STSV+LS
Sbjct: 880 FTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP-TGFPQNLHSEGTTSTSVQLS 938
Query: 4175 WSEPV--NPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQP 4232
W PV NG I +Y ++ R N + E+++ T TGL+P
Sbjct: 939 WQPPVLAERNGIITKYTLLYRDI------NIPLLPMEQLIVPADTT------MTLTGLKP 986
Query: 4233 WTQCEYKIYTWNSAGHTCSSWNV-VRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQS 4291
T + K+ S G S +V RTL P + + ++ +L+SW PE
Sbjct: 987 DTTYDVKVRAHTSKGPGPYSPSVQFRTL--PVDQVFAKNFHVKAVMKTSVLLSWEIPENY 1044
Query: 4292 N 4292
N
Sbjct: 1045 N 1045
Score = 128 bits (321), Expect = 2e-28
Identities = 191/833 (22%), Positives = 332/833 (39%), Gaps = 147/833 (17%)
Query: 2326 EAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTK 2385
E P G+VN+ GS +V+W L + P+G N +L +
Sbjct: 246 EIMPGGSVNITCVAVGSPMPYVKWM--LGAEDLTPEDDM--------PIGRN--VLELND 293
Query: 2386 VMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSS 2445
V S T + + G++ Q+ + + PPG P ++
Sbjct: 294 VRQSANYTCVAMSTLGVI---EAIAQITVK-----------ALPKPPGTPV------VTE 333
Query: 2446 ATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTE 2505
+T TS+ + W + N Y +Q + +S + E+ + A+ Y V+ L PY++
Sbjct: 334 STATSITLTWDS---GNPEPVSYYIIQHKPKNSEELYKEI--DGVATTRYSVAGLSPYSD 388
Query: 2506 YMFRLVASNGFGSAHSSWIPFMTAEDKPGPVVPPILLDVKSRMM-----LVTWQHPRKSN 2560
Y FR+VA N G S P +T + P P DV++RM+ LV W+ P + N
Sbjct: 389 YEFRVVAVNNIGRGPPS-EPVLTQTSEQAPSSAP--RDVQARMLSSTTILVQWKEPEEPN 445
Query: 2561 GVITHYNIYLHGRLYLRTPGNVTN------------CTVMHLHPYTAYKFQVEACTSKGC 2608
G I Y +Y Y P N T+ +L P Y +V A TS G
Sbjct: 446 GQIQGYRVY-----YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 500
Query: 2609 SLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEE 2668
V T G P + + ++ TS+++SW PP + + N+ + + G+
Sbjct: 501 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR--SDTIANYELVYK-DGEHG 557
Query: 2669 VTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQ 2728
+T+ S R L P + Y +R+ + G S+A + T S+P+
Sbjct: 558 EEQRITIEPGTSYRL----QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPS-AP 612
Query: 2729 PPVVTVLEPD--AVQVTWKPPLI--QNGDILSYEIHM-------PDPHITLTNVTSAVLS 2777
P ++ P ++ V+W+PP + QNG I Y I PH + + S
Sbjct: 613 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH-EILGIPSDTTK 671
Query: 2778 QKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGP---LSVIPLSE 2834
+ L +T Y +T+ A + +G ESL + T+ VP GP + V ++
Sbjct: 672 YLLEQLEKWTEYRITVTAHTD----VGPGPESLSVLIRTNEDVPS--GPPRKVEVEAVNS 725
Query: 2835 SYVVISWQP--PSKPNGPNLRYEL--LRRKIQQPLASNPPEDLNRWHNIYSGTQWLYED- 2889
+ V +SW+ P+K +G Y++ +R + +P +D+ + + QW ++D
Sbjct: 726 TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDV-----MLADAQWEFDDT 780
Query: 2890 -------KGLSRFTTYEYMLFVHNSVG-FTPSREVTVTTLAGLPERGANLTASVLNHTAI 2941
GL T+Y + + + G S+ V+T +P + V+NHT +
Sbjct: 781 TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK----PRLVINHTQM 836
Query: 2942 D---VRWAKPTVQDLQGEVEYYTLFWSSATSN--DSLKILPDVNSHVIGHLKPNTEYWIF 2996
+ ++W P D G ++ Y L + +L+ + + Y
Sbjct: 837 NTALIQWHPPV--DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR 894
Query: 2997 ISVFN----GVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSP--SNPNGVV 3050
+S N G + + G PQ + ST+V++ W P + NG++
Sbjct: 895 LSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGT---TSTSVQLSWQPPVLAERNGII 951
Query: 3051 TEYSIYVNNKLYKTGMNVP------------GSFILRDLSPFTIYDIQVEVCT 3091
T+Y++ LY+ +N+P + L L P T YD++V T
Sbjct: 952 TKYTL-----LYR-DINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 998
Score = 114 bits (286), Expect = 2e-24
Identities = 197/794 (24%), Positives = 311/794 (39%), Gaps = 95/794 (11%)
Query: 4245 SAGHTC---SSWNVVR-----TLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQ 4296
SA +TC S+ V+ T++A P+ PV++ + L PE + I
Sbjct: 297 SANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYII 356
Query: 4297 SYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTS-GGCSTSKPTSITTLEAA 4355
++ + +E LY T Y+ L P+S Y + + A + G S+P T E A
Sbjct: 357 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA 416
Query: 4356 PSEVSPPDLWA--VSATQMNVCWSPPTVQNGKITKYLVRYDN----------KESLAGQG 4403
PS +P D+ A +S+T + V W P NG+I Y V Y K ++A
Sbjct: 417 PSS-APRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 475
Query: 4404 LCLLVSHLQPYSQYNFSLVACTN-GGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEI 4462
+ + +L P Y+ ++A T+ G S T +P + + SI +
Sbjct: 476 ITT-IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL 534
Query: 4463 TWKPPRNPNGQIRSYEL-RRDGTI-----VYTGLETRYRDFTLTPGVEYSYTVTASNSQG 4516
+W PPR+ I +YEL +DG + T YR L P Y + + A + QG
Sbjct: 535 SWTPPRSDT--IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQG 592
Query: 4517 -GILSPLVKDRTSPSAPSGMEPPKLQARGPQE--ILVNWDPPV--RTNGDIINYTLFIRE 4571
G + + RT S PS P + P ILV+W PP + NG I Y++
Sbjct: 593 LGASTAEISARTMQSKPSA-PPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
Query: 4572 LFERETKIIHINTTHNSFGMQS----YIVNQLKPFHRYEIRIQACTTLGCASSDWT-FIQ 4626
+ + K H G+ S Y++ QL+ + Y I + A T +G + I+
Sbjct: 652 VDGEDDK------PHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR 705
Query: 4627 TPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPL--QPNGKVLYYELYRRQIATQPRKS 4684
T E P PP +EV+ +V + W P+ + +G++ Y+++ ++ K
Sbjct: 706 TNEDVP-SGPPRKVEVEAVNS---TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKG 761
Query: 4685 NPVL-----------IYNGSSTSFIDSELLPFTEYEYQVWAVNSAGK-APSSWTWCRTGP 4732
P+L + + I S L P T Y V A + G A S T
Sbjct: 762 QPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 821
Query: 4733 APPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTL 4792
A P R H +T A++ P G + YRL G + + E + T +
Sbjct: 822 AVPGKPRLVINHTQMNT-ALIQWHPPVDTFGPLQGYRL----KFGRKDM--EPLTTLEFS 874
Query: 4793 HGLQAFTNYSIGVEACTCFNCCSKGPTA-------ELRTHPAPPSGLSSP--QIGTLASR 4843
FT I A F ++ E+ P+G GT S
Sbjct: 875 EKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGT-TST 933
Query: 4844 TASFRWSPPMFP--NGVIHSYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQP 4901
+ W PP+ NG+I Y L + D +P P +E +L GL+P
Sbjct: 934 SVQLSWQPPVLAERNGIITKYTLLYR-----DINIPLLP--MEQLIVPADTTMTLTGLKP 986
Query: 4902 YTTYKLRVVAHNEVG-STASEWISFTTQKELPQYRAPFSVDSNLSV-VCVNWSDTFLLNG 4959
TTY ++V AH G S + F T + F V + + V ++W N
Sbjct: 987 DTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNS 1046
Query: 4960 QLKEYVLTDGGRRV 4973
+ +L D G+ V
Sbjct: 1047 AMPFKILYDDGKMV 1060
Score = 110 bits (275), Expect = 4e-23
Identities = 181/769 (23%), Positives = 297/769 (38%), Gaps = 103/769 (13%)
Query: 3456 VNTYSYTDVNLKPYMTYEYRISAWNSYGRG-LSKAVRARTKEDVPQGVSPPTWTKIDNLE 3514
V T Y+ L PY YE+R+ A N+ GRG S+ V +T E P ++ +
Sbjct: 373 VATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLS-S 431
Query: 3515 DTIVLNWRKPIQSNGPI----IYYIL---------LRNGIERFRGTSLSFSDKEGIQPFQ 3561
TI++ W++P + NG I +YY + +++ + + T++ + P +
Sbjct: 432 TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG-----NLVPQK 486
Query: 3562 EYSYQLKACTVAGCA-TSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKS---- 3616
YS ++ A T G SS + T GVP L S ++ LSW+ P
Sbjct: 487 TYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIAN 546
Query: 3617 -NGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGC-TSSEPFLG 3674
V K+ + + + I T+ R Q GL+P + Y F L A + G S+
Sbjct: 547 YELVYKDGEHGEEQRITIEPGTSYRLQ----GLKPNSLYYFRLAARSPQGLGASTAEISA 602
Query: 3675 QTLQAAPEGVWVTPRHIII---NSTTVELYWSLP--EKPNGLVSQYQLSRNG-------- 3721
+T+Q+ P P+ I +ST++ + W P EK NG++++Y +
Sbjct: 603 RTMQSKPS---APPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKP 659
Query: 3722 NLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTG-GGSSASDDYIVQTPMSTPEEIYPPYN 3780
+ + S+ + + LE + Y + T G S +++T P
Sbjct: 660 HEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVE 719
Query: 3781 ITVIGPYSIFVAWIPP----------GILIPEI----------PVEYNVLLNDGSVTPLA 3820
+ + S+ V+W P G + + P+ +V+L D
Sbjct: 720 VEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ---WE 776
Query: 3821 FSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSR-MFVKTPEAAPMDLNSPVLKALG 3879
F ++ L P T Y + + A G S+ V T A P +
Sbjct: 777 FDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQM 836
Query: 3880 SACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGD-----TLRP 3934
+ + I+W PP G + YR G ++ L LEF ++ D +
Sbjct: 837 NTAL-IQWHPPVDTFGPLQG---YRLKFGRKDMEPL-----TTLEFSEKEDHFTATDIHK 887
Query: 3935 FTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAP-WAQATSAHSVLLNWTKP--ESP 3991
Y +R+ A N G E + E P FP ++ T++ SV L+W P
Sbjct: 888 GASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAER 947
Query: 3992 NGIISHYRVVYQERPDDPTFNSPTV-HAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAG 4050
NGII+ Y ++Y++ N P + + L GL+P TTY + V A G
Sbjct: 948 NGIITKYTLLYRD------INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKG 1001
Query: 4051 E-ILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFL- 4108
SP +TL +NF V+ ++LL W P N + ++ DG +
Sbjct: 1002 PGPYSPSVQFRTLPVDQVFAKNFHVKAVMK-TSVLLSWEIPENYNSAMPFKILYDDGKMV 1060
Query: 4109 -EYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPD 4156
E G Q L L P Y+ L T G + Q T + PD
Sbjct: 1061 EEVDGRATQKLIVNLKPEKSYSFVL---TNRGNSAGGLQHRVTAKTAPD 1106
Score = 106 bits (265), Expect = 5e-22
Identities = 173/765 (22%), Positives = 285/765 (37%), Gaps = 103/765 (13%)
Query: 4150 TDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADE 4209
T +A P P V +TS+ L+W + N + + Y +I Q +
Sbjct: 318 TVKALPKPPGTPVVTESTATSITLTWD---SGNPEPVSYYII-----------QHKPKNS 363
Query: 4210 KIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPP 4269
+ ++ E + T Y+ GL P++ E+++ N+ G S V+ +P
Sbjct: 364 EELYKEIDGVATT-RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 422
Query: 4270 VISYVSMNPQKLLISWIPPEQSNGIIQSYRLQ---------RNEMLYPFSFDPVTFNYTD 4320
+ ++ +L+ W PE+ NG IQ YR+ N M + + +T T
Sbjct: 423 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT---TI 479
Query: 4321 EELLPFSTYSYALQACTS-GGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPP 4379
L+P TYS + A TS G S + T P + S T + + W+PP
Sbjct: 480 GNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPP 539
Query: 4380 TVQNGKITKYLVRYDNKESLAGQ------GLCLLVSHLQPYSQYNFSLVACTNGGCTASV 4433
++ I Y + Y + E Q G + L+P S Y F L A + G AS
Sbjct: 540 --RSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST 597
Query: 4434 SK-SAWTMEALPENMDSPTLQVT----GSESIEITWKPP--RNPNGQIRSYELRRDGTIV 4486
++ SA TM++ P +P ++ S SI ++W+PP NG I Y ++
Sbjct: 598 AEISARTMQSKP---SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK------ 648
Query: 4487 YTGLE----------------TRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDRTSP 4529
YT ++ T+Y L EY TVTA G G S V RT+
Sbjct: 649 YTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNE 708
Query: 4530 SAPSGMEPPK---LQARGPQEILVNWDPPV--RTNGDIINYTLFIRELFERETK------ 4578
PSG PP+ ++A + V+W PV + +G I Y + + E K
Sbjct: 709 DVPSG--PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLK 766
Query: 4579 ---IIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLG-CASSDWTFIQTPEIAPLM 4634
+ + I++ L+P Y + + A TT G A S + T P
Sbjct: 767 DVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVP-- 824
Query: 4635 QPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSS 4694
P L + T + W P+ G + + YR + + + L ++
Sbjct: 825 -GKPRLVINHTQ---MNTALIQWHPPVDTFGPL---QGYRLKFGRKDMEPLTTLEFSEKE 877
Query: 4695 TSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVN 4754
F +++ Y +++ A N G P G H +T V
Sbjct: 878 DHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGF-PQNLHSEGTTSTSVQ 936
Query: 4755 IS----APGKPNGIVSLYRLFSSSAHGAETVLSEGMA---TQQTLHGLQAFTNYSIGVEA 4807
+S + NGI++ Y L + + + + T TL GL+ T Y + V A
Sbjct: 937 LSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRA 996
Query: 4808 CTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPP 4852
T P+ + RT P + + + + W P
Sbjct: 997 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP 1041
Score = 97.1 bits (240), Expect = 4e-19
Identities = 188/784 (23%), Positives = 316/784 (40%), Gaps = 86/784 (10%)
Query: 1920 GLQPFTEYLYRVIASHE-GGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEP 1978
GL P+++Y +RV+A + G S+ +T+ AP S P + R L+ +I V W EP
Sbjct: 382 GLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP 441
Query: 1979 -VVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTL 2037
G I+ Y + Y+ D T+ + + V S +T I L+P K Y+V + A T
Sbjct: 442 EEPNGQIQGYRV-YYTMDPTQ--HVNNWMKHNVADSQITTI-GNLVPQKTYSVKVLAFTS 497
Query: 2038 AGCTESSHALNISTPQEAPQEVQPPVAKSLP---SSLLLSWNPPKKANGIITQYCLYMDG 2094
G S + + T P QP K+ P +S+LLSW PP +++ I +Y DG
Sbjct: 498 IGDGPLSSDIQVITQTGVPG--QPLNFKAEPESETSILLSWTPP-RSDTIANYELVYKDG 554
Query: 2095 RLIYSGSEE--------NYTVTDLAVFTPHQFLLSACTHVGC-TNSSWVLLYTAQLPPEH 2145
G E+ +Y + L + + F L+A + G +++ + T Q P
Sbjct: 555 E---HGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSA 611
Query: 2146 VDSPV-LTVLDSRTIHIQWKQP--RKISGILERY-VLYMSNHTHDFTIWSVIYNSTELFQ 2201
+ T S +I + W+ P K +GI+ Y + Y + D ++ ++ +
Sbjct: 612 PPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTK 671
Query: 2202 DHMLQYVLPGNKYLIKLGACTGGGCTVSEASEAL-TDEDIPEGVPAP-KAHSYSPDSFNV 2259
++L+ + +Y I + A T G S + T+ED+P G P + + + S V
Sbjct: 672 -YLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKV 730
Query: 2260 SWTEPEYPN---GVITSYGLY--------------LDGILI-------HNSSELSYRAYG 2295
SW P PN G I Y ++ L +++ +++E G
Sbjct: 731 SWRSP-VPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISG 789
Query: 2296 FAPWSLHSFRVQACTAK--GCALGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPF 2353
P + +S V A T K G P + + T P G + + A ++W P
Sbjct: 790 LQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVP--GKPRLVINHTQMNTALIQWHPPV 847
Query: 2354 RPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVN 2413
G L L G ++P +T + +S +E + + +Y +++
Sbjct: 848 DTFGPLQGYRLKFGRKDMEP---------LTTLEFSEKEDHF--TATDIHKGASYVFRLS 896
Query: 2414 ISNSQGSLITDPITIAMPPGAPDGVLPPRLSS--ATPTSLQVVWSTPARNNAPG-SPRYQ 2470
N G I++P P G P L S T TS+Q+ W P G +Y
Sbjct: 897 ARNKVGFGEEMVKEISIPEEVPTG-FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYT 955
Query: 2471 LQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAE 2530
L R + +E P A + ++ L+P T Y ++ A G S P +
Sbjct: 956 LLYRDINIPLLPMEQLIVP-ADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYS--PSVQFR 1012
Query: 2531 DKPGPVVPPILLDVKSRM---MLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGNVTNCTV 2587
P V VK+ M +L++W+ P N + +Y G++ G T +
Sbjct: 1013 TLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLI 1072
Query: 2588 MHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGI-PSPELFSDTPTSVIISWQP 2646
++L P +Y F T++G S V T AP+ + P T +I+ Q
Sbjct: 1073 VNLKPEKSYSF---VLTNRGNSAGGLQHRV-TAKTAPDVLRTKPAFIGKTNLDGMITVQL 1128
Query: 2647 PTHP 2650
P P
Sbjct: 1129 PEVP 1132
Score = 94.0 bits (232), Expect = 4e-18
Identities = 189/790 (23%), Positives = 289/790 (36%), Gaps = 77/790 (9%)
Query: 1949 TTGAAPQSVPTPSRVRSLNGYSIEVTWD----EPVVRGVIEKYILKAYSEDSTRPPRMPS 2004
T A P+ TP S SI +TWD EPV +I+ +P
Sbjct: 318 TVKALPKPPGTPVVTES-TATSITLTWDSGNPEPVSYYIIQH-----------KPKNSEE 365
Query: 2005 ASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVA 2064
E + + GL P+ +Y + A G S + T ++AP V
Sbjct: 366 LYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQ 425
Query: 2065 KSLPSS--LLLSWNPPKKANGIITQYCLY--MDG-RLIYSGSEENY------TVTDLAVF 2113
+ SS +L+ W P++ NG I Y +Y MD + + + + N T+ +L
Sbjct: 426 ARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQ 485
Query: 2114 TPHQFLLSACTHVGCTN-SSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGI 2172
+ + A T +G SS + + T P + +I + W PR S
Sbjct: 486 KTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR--SDT 543
Query: 2173 LERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEAS 2232
+ Y L + H I T + LQ + P + Y +L A + G S A
Sbjct: 544 IANYELVYKDGEHGEEQRITIEPGTS----YRLQGLKPNSLYYFRLAARSPQGLGASTAE 599
Query: 2233 -EALTDEDIPEGVPAP-KAHSYSPDSFNVSWTEP--EYPNGVITSYGLY---LDG----- 2280
A T + P P S S S VSW P E NG+IT Y + +DG
Sbjct: 600 ISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKP 659
Query: 2281 --ILIHNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPL-VENRTLEAPPEGTVN-VF 2336
IL S Y W+ + V A T G L V RT E P G V
Sbjct: 660 HEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVE 719
Query: 2337 VKTQGSRKAHVRWEAPFRPNG----LLTHSVLFTGIFYVDPVGNNYTL-LNVTKVMYSGE 2391
V+ S V W +P PN + + V + + +P G + + + +
Sbjct: 720 VEAVNSTSVKVSWRSPV-PNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFD 778
Query: 2392 ETNLW-VLIDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTS 2450
+T ++I GL P T+Y++ V ++G + GA G ++ +
Sbjct: 779 DTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNT 838
Query: 2451 LQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRL 2510
+ W P P Y+L+ D FS + +D+ Y+FRL
Sbjct: 839 ALIQWHPPVDTFGP-LQGYRLKFGRKDMEPLTTLEFSEKEDH--FTATDIHKGASYVFRL 895
Query: 2511 VASNGFGSAHSSWIPFMTAEDKPGPVVPPILLD-VKSRMMLVTWQHP--RKSNGVITHY- 2566
A N G E+ P + + S + ++WQ P + NG+IT Y
Sbjct: 896 SARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYT 955
Query: 2567 ------NIYLHGRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTL 2620
NI L L P + T T+ L P T Y +V A TSKG S TL
Sbjct: 956 LLYRDINIPLLPMEQLIVPADTT-MTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTL 1014
Query: 2621 PGAPEGIPSPELFSDTPTSVIISWQPPTHPNG------LVENFTIERRVKGKEEVTTLVT 2674
P + + + TSV++SW+ P + N L ++ + V G+ +V
Sbjct: 1015 PVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN 1074
Query: 2675 LPRSHSMRFI 2684
L S F+
Sbjct: 1075 LKPEKSYSFV 1084
Score = 82.8 bits (203), Expect = 8e-15
Identities = 118/478 (24%), Positives = 193/478 (40%), Gaps = 64/478 (13%)
Query: 1040 SHLDVNNLLGCSKTP--FQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIY 1097
++L V L + P F PP ++ ++N++ SP + Y G E
Sbjct: 221 ANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSP----MPYVKWMLGAEDL 276
Query: 1098 TTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVA-VTYKTKPGVPEGNLTLSY 1156
T ED P D+ Y+ +T G ++A +T K P P +
Sbjct: 277 TPEDDMPIGRNVLELNDVRQSANYTCVAMSTL--GVIEAIAQITVKALPKPPGTPV---- 330
Query: 1157 IIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSA-TIWNLVPFAK 1215
+ + S+TLTW S P+ YI+ P + +G T+ ++ L P++
Sbjct: 331 VTESTATSITLTWD--SGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSD 388
Query: 1216 YDFSVQACTS-GGCLHSLPI-TVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGII 1273
Y+F V A + G S P+ T T+ QAP + + +SST + V+W P E NG I
Sbjct: 389 YEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQI 448
Query: 1274 IRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYT 1333
Y +Y T + T + W+ H+ +S +TTI L P
Sbjct: 449 QGYRVYY-----TMDPTQ------HVNNWMK-HNVADS----------QITTIGNLVPQK 486
Query: 1334 KYEFRVLAVNMAG-SVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKP-ADNVTR 1391
Y +VLA G S+ + T P + P S S+ +SW P +D +
Sbjct: 487 TYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIAN 546
Query: 1392 GKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVG 1451
++V D E +Q I + SY ++GLKP +Y F + + G
Sbjct: 547 YELVYKD----GEHGEEQRITI----------EPGTSYRLQGLKPNSLYYFRLAARSPQG 592
Query: 1452 C-VTSASGAGQTLAAAPAQLRPP---LVKGINSTTIHLKWFPP--EELNGPSPIYQLE 1503
++A + +T+ + P+ PP +ST+I + W PP E+ NG Y ++
Sbjct: 593 LGASTAEISARTMQSKPS--APPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK 648
Score = 81.6 bits (200), Expect = 2e-14
Identities = 121/486 (24%), Positives = 184/486 (37%), Gaps = 72/486 (14%)
Query: 1061 RGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDT------- 1113
+ ++ SS+ I + W P+ PN G+ +Y T D + +
Sbjct: 425 QARMLSSTTILVQWKEPEEPNGQI-------QGYRVYYTMDPTQHVNNWMKHNVADSQIT 477
Query: 1114 ---DLLPYTKYSYYIET-TNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTW 1169
+L+P YS + T++ S + T+ GVP L P S+ L+W
Sbjct: 478 TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-AEPESETSILLSW 536
Query: 1170 TTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGC- 1228
T +S I Y L G+ TS + L P + Y F + A + G
Sbjct: 537 TP--PRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 594
Query: 1229 LHSLPITVTTAQ----APPQRLSPPKMQKISSTELHVEWSPPA--ELNGIIIRYELYMRR 1282
+ I+ T Q APPQ +S SST + V W PP + NGII Y +
Sbjct: 595 ASTAEISARTMQSKPSAPPQDIS---CTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 651
Query: 1283 LRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAV 1342
+ + PH + ++ T + LE +T+Y V A
Sbjct: 652 VDGEDD---------------KPHEILGIPSDT------TKYLLEQLEKWTEYRITVTAH 690
Query: 1343 NMAG-SVSSAWVSERTGESAPVFMIPP---SVFPLSSYSLNISWEKPADNVTRGKVVGYD 1398
G S V RT E P PP V ++S S+ +SW P N G++ GY
Sbjct: 691 TDVGPGPESLSVLIRTNEDVPSG--PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQ 748
Query: 1399 INML-SEQSPQQSIPMAFSQLLHTAK-----SQELSYTVEGLKPYRIYEFTITLCNSVG- 1451
++ + E + PM +L A+ + E + GL+P Y T+T + G
Sbjct: 749 VHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGD 808
Query: 1452 CVTSASGAGQTLAAAPAQLRPPLVKGINST---TIHLKWFPPEELNGPSPIYQLERRESS 1508
S T A P +P LV IN T T ++W PP + GP Y+L+
Sbjct: 809 GARSKPKLVSTTGAVPG--KPRLV--INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKD 864
Query: 1509 LPALMT 1514
+ L T
Sbjct: 865 MEPLTT 870
Score = 66.2 bits (160), Expect = 8e-10
Identities = 113/473 (23%), Positives = 179/473 (37%), Gaps = 85/473 (17%)
Query: 1066 SSSAINLSWSPP--DSPNAHWLTYSLLRDGFEIYTTEDQYPYSI--------QYFLDTDL 1115
SS++I +SW PP + N YS+ + ED P+ I +Y L+ L
Sbjct: 622 SSTSILVSWQPPPVEKQNGIITEYSIK---YTAVDGEDDKPHEILGIPSDTTKYLLE-QL 677
Query: 1116 LPYTKYSYYIET-TNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTL-- 1172
+T+Y + T+V S++V +T VP G + + S SV ++W +
Sbjct: 678 EKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVP 737
Query: 1173 SNQSGPIEKYILSCAPLAGGQPC------------VSYEGHETSA---TIWNLVPFAKYD 1217
+ Q G I Y + + G+P +E +T+ I L P Y
Sbjct: 738 NKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYS 797
Query: 1218 FSVQACTS-GGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELH---VEWSPPAELNGII 1273
+V A T+ G S P V+T A P + P++ I+ T+++ ++W PP + G +
Sbjct: 798 LTVTAYTTKGDGARSKPKLVSTTGAVPGK---PRLV-INHTQMNTALIQWHPPVDTFGPL 853
Query: 1274 IRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYT 1333
Y L R TT E S + T T +
Sbjct: 854 QGYRLKFGRKDMEPLTTLEFSE------------------------KEDHFTATDIHKGA 889
Query: 1334 KYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFP-------LSSYSLNISWEKPA 1386
Y FR+ A N G E + + P+ FP +S S+ +SW+ P
Sbjct: 890 SYVFRLSARNKVG------FGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPV 943
Query: 1387 DNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITL 1446
G + Y + P +PM QL+ A + + T+ GLKP Y+ +
Sbjct: 944 LAERNGIITKYTLLYRDINIP--LLPM--EQLIVPA---DTTMTLTGLKPDTTYDVKVRA 996
Query: 1447 CNSVG-CVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSP 1498
S G S S +TL + VK + T++ L W PE N P
Sbjct: 997 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMP 1049
Score = 46.2 bits (108), Expect = 8e-04
Identities = 96/397 (24%), Positives = 145/397 (36%), Gaps = 70/397 (17%)
Query: 1115 LLPYTKYSYYIETTNVHGS-TRSVAVTYKTKPGVP-EGNLTLSYIIPIGSDSVTLTWTTL 1172
L P T YS + G RS T VP + L +++ ++ + W
Sbjct: 790 LQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHT---QMNTALIQWHPP 846
Query: 1173 SNQSGPIEKYILSCA-----PLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGG 1227
+ GP++ Y L PL + + E T ++ A Y F + A G
Sbjct: 847 VDTFGPLQGYRLKFGRKDMEPLT----TLEFSEKEDHFTATDIHKGASYVFRLSARNKVG 902
Query: 1228 ----CLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPP--AELNGIIIRYELYMR 1281
+ + I PQ L + +ST + + W PP AE NGII +Y L R
Sbjct: 903 FGEEMVKEISIPEEVPTGFPQNLHS---EGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 959
Query: 1282 RLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLA 1341
+ L P E + P T T+TGL+P T Y+ +V A
Sbjct: 960 DINIP----------------LLPM-------EQLIVPADTTMTLTGLKPDTTYDVKVRA 996
Query: 1342 VNMAG-SVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPAD-NVTRGKVVGYDI 1399
G S V RT VF V + S+ +SWE P + N + YD
Sbjct: 997 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDD 1056
Query: 1400 NMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTIT-LCNSVGCV---TS 1455
+ E+ ++ +Q+L + LKP + Y F +T NS G + +
Sbjct: 1057 GKMVEEVDGRA-------------TQKL---IVNLKPEKSYSFVLTNRGNSAGGLQHRVT 1100
Query: 1456 ASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEE 1492
A A L PA + + G+ T+ L P E
Sbjct: 1101 AKTAPDVLRTKPAFIGKTNLDGM--ITVQLPEVPANE 1135
Score = 43.5 bits (101), Expect = 0.005
Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 12/93 (12%)
Query: 4895 SLGGLQPYTTYKLRVVAHNEVG-STASEWISFTTQKELPQYRAPFSVDSNL---SVVCVN 4950
S+ GL PY+ Y+ RVVA N +G SE + T ++ P AP V + + + + V
Sbjct: 379 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS-SAPRDVQARMLSSTTILVQ 437
Query: 4951 WSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLYI 4983
W + NGQ++ Y RVY +D T ++
Sbjct: 438 WKEPEEPNGQIQGY-------RVYYTMDPTQHV 463
Score = 41.2 bits (95), Expect = 0.027
Identities = 38/138 (27%), Positives = 62/138 (44%), Gaps = 11/138 (7%)
Query: 3026 PEVVIINSTAVRVIWTSPSNPNGV---VTEYSIYVNNKLYKTGMNVPGS-FILRDLSPFT 3081
P V +T++ + W S NP V + ++ + +LYK V + + + LSP++
Sbjct: 329 PVVTESTATSITLTWDS-GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 387
Query: 3082 IYDIQV-EVCTIYACVKSNGTQITTVEDTPSDIPTPT-IRGITSRSLQIDWVSPRKPNGI 3139
Y+ +V V I S T E PS P R ++S ++ + W P +PNG
Sbjct: 388 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 447
Query: 3140 ILGYDLLWKTWYPCAKTQ 3157
I GY + +Y TQ
Sbjct: 448 IQGY----RVYYTMDPTQ 461
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 149 bits (375), Expect = 9e-35
Identities = 204/801 (25%), Positives = 341/801 (42%), Gaps = 82/801 (10%)
Query: 3834 LTPFTQYEIRIQACQNGSCGVSSRMFV-----KTPEAAPMDLNSPVLKALGSACIEIKWM 3888
L+P++ YE R+ A N G S + + P +AP D+ + + L S I ++W
Sbjct: 370 LSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQA---RMLSSTTILVQWK 426
Query: 3889 PPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSK 3948
PE+PNG I Y +Y + + + + G+ L P Y +V A S
Sbjct: 427 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGN-LVPQKTYSVKVLAFTSI 485
Query: 3949 GS---VESLWSLTQT-LEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGIISHYRVVYQE 4004
G + +TQT + P +F A + S S+LL+WT P S I++Y +VY++
Sbjct: 486 GDGPLSSDIQVITQTGVPGQPLNFKA---EPESETSILLSWTPPRSDT--IANYELVYKD 540
Query: 4005 RPDDPTFNSPTVHAFTVK-GTSHQAHLYGLEPFTTYRIGVVAANHAGEILSPWTL-IQTL 4062
T++ GTS++ L GL+P + Y + A + G S + +T+
Sbjct: 541 GEHGEE------QRITIEPGTSYR--LQGLKPNSLYYFRLAARSPQGLGASTAEISARTM 592
Query: 4063 ESSPSGLRNFIVEQKENGRALLLQWSEPM--RTNGVIKTYNIF-------SDGFLEYSGL 4113
+S PS I + ++L+ W P + NG+I Y+I D E G+
Sbjct: 593 QSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGI 652
Query: 4114 ---NRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPL--WTDEAPPDSQLAPTVHSVKS 4168
++L +L+ +T Y +T+ A T G + L ++ P V +V S
Sbjct: 653 PSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 712
Query: 4169 TSVELSWSEPVNPN---GKIIRYEV-IRRCFEGKAWGNQTIQ----ADEKIVFTEYNTER 4220
TSV++SW PV PN G+I Y+V R G+ G ++ AD + F + TE
Sbjct: 713 TSVKVSWRSPV-PNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDD-TTEH 770
Query: 4221 NTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSW-NVVRTLQAPPEGLSPPVISYVSMNPQ 4279
+ + +GLQP T + + + G S +V T A P G VI++ MN
Sbjct: 771 DMII---SGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVP-GKPRLVINHTQMNTA 826
Query: 4280 KLLISWIPPEQSNGIIQSYRLQ--RNEM--LYPFSFDPVTFNYTDEELLPFSTYSYALQA 4335
LI W PP + G +Q YRL+ R +M L F ++T ++ ++Y + L A
Sbjct: 827 --LIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSA 884
Query: 4336 CTSGGCSTSKPTSITTLEAAPSEVSPPDLWA--VSATQMNVCWSPPTV--QNGKITKYLV 4391
G I+ E P+ P +L + ++T + + W PP + +NG ITKY +
Sbjct: 885 RNKVGFGEEMVKEISIPEEVPTGF-PQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYTL 943
Query: 4392 RYDN--------KESLAGQGLCLLVSHLQPYSQYNFSLVACTNGGCTASVSKSAWTMEAL 4443
Y + ++ + + ++ L+P + Y+ + A T+ G S S
Sbjct: 944 LYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKG-PGPYSPSVQFRTLP 1002
Query: 4444 PENMDSPTLQVTG--SESIEITWKPPRNPNGQIRSYELRRDGTIV--YTGLETRYRDFTL 4499
+ + + V S+ ++W+ P N N + L DG +V G T+ L
Sbjct: 1003 VDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNL 1062
Query: 4500 TPGVEYSYTVTASNSQGGILSPLVKDRTSPSAPSGMEPPKLQARGPQEILVNWDPPVRTN 4559
P YS+ +T + G L V +T+P +P + ++ P V N
Sbjct: 1063 KPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDV-LRTKPAFIGKTNLDGMITVQLPEVPAN 1121
Query: 4560 GDIINYTLFIRELFERETKII 4580
+I Y + I L + K I
Sbjct: 1122 ENIKGYYIIIVPLKKSRGKFI 1142
Score = 144 bits (364), Expect = 2e-33
Identities = 195/781 (24%), Positives = 311/781 (39%), Gaps = 80/781 (10%)
Query: 3561 QEYSYQLKACTVAGCATSSKVVAATTQGVPESILPPSITALSAVALHLSWSV--PEKSNG 3618
Q +Y A + G + + T + +P+ P +T +A ++ L+W PE +
Sbjct: 283 QSANYTCVAMSTLGVIEA--IAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSY 340
Query: 3619 VIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGC-TSSEPFLGQTL 3677
I +++ + + D +++V GL PY++Y F + A + G SEP L QT
Sbjct: 341 YIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTS 400
Query: 3678 QAAPEGVWVTPRHIIINSTTVELYWSLPEKPNGLVSQYQL-------SRNGNLLFLGGSE 3730
+ AP + +++STT+ + W PE+PNG + Y++ N + ++
Sbjct: 401 EQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVAD 460
Query: 3731 EQNFTDKNLEPNSRYTYKLEVKTG-GGSSASDDYIVQTPMSTPEEIYPPYNITV--IGPY 3787
Q T NL P Y+ K+ T G S D V T P + P N
Sbjct: 461 SQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQ---PLNFKAEPESET 517
Query: 3788 SIFVAWIPPGILIPEIPVEYNVLLNDGS-VTPLAFSVGHHQSTLLENLTPFTQYEIRIQA 3846
SI ++W PP + Y ++ DG ++ S L+ L P + Y R+ A
Sbjct: 518 SILLSWTPPR---SDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAA 574
Query: 3847 CQNGSCG-----VSSRMFVKTPEAAPMDLNSPVLKALGSACIEIKWMPP--EKPNGIIIN 3899
G +S+R P A P D++ + S I + W PP EK NGII
Sbjct: 575 RSPQGLGASTAEISARTMQSKPSAPPQDIS---CTSPSSTSILVSWQPPPVEKQNGIITE 631
Query: 3900 YFIYRRPAGIEEE---SVLFVWSEGALEFMDEGDTLRPFTLYEYRVRACNSKG-SVESLW 3955
Y I E++ +L + S+ +++ L +T Y V A G ESL
Sbjct: 632 YSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQ---LEKWTEYRITVTAHTDVGPGPESLS 688
Query: 3956 SLTQTLEAPPQDFPAP-WAQATSAHSVLLNWTK--PESPNGIISHYRVVYQERPDDPTFN 4012
L +T E P P +A ++ SV ++W P +G I Y+V Y +
Sbjct: 689 VLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKG 748
Query: 4013 SPTVHAFTVKG--------TSHQAHLYGLEPFTTYRIGVVAANHAGE-ILSPWTLIQTLE 4063
P + + T H + GL+P T+Y + V A G+ S L+ T
Sbjct: 749 QPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 808
Query: 4064 SSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSD-------GFLEYSGLNRQ 4116
+ P R I + N L+QW P+ T G ++ Y + LE+S
Sbjct: 809 AVPGKPRLVINHTQMN--TALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDH 866
Query: 4117 FLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPDSQLAPTVHS--VKSTSVELS 4174
F + Y L A + G + + E P + +HS STSV+LS
Sbjct: 867 FTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP-TGFPQNLHSEGTTSTSVQLS 925
Query: 4175 WSEPV--NPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNTERNTFMYNDTGLQP 4232
W PV NG I +Y ++ R N + E+++ T TGL+P
Sbjct: 926 WQPPVLAERNGIITKYTLLYRDI------NIPLLPMEQLIVPADTT------MTLTGLKP 973
Query: 4233 WTQCEYKIYTWNSAGHTCSSWNV-VRTLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQS 4291
T + K+ S G S +V RTL P + + ++ +L+SW PE
Sbjct: 974 DTTYDVKVRAHTSKGPGPYSPSVQFRTL--PVDQVFAKNFHVKAVMKTSVLLSWEIPENY 1031
Query: 4292 N 4292
N
Sbjct: 1032 N 1032
Score = 128 bits (321), Expect = 2e-28
Identities = 191/833 (22%), Positives = 332/833 (39%), Gaps = 147/833 (17%)
Query: 2326 EAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTK 2385
E P G+VN+ GS +V+W L + P+G N +L +
Sbjct: 233 EIMPGGSVNITCVAVGSPMPYVKWM--LGAEDLTPEDDM--------PIGRN--VLELND 280
Query: 2386 VMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSS 2445
V S T + + G++ Q+ + + PPG P ++
Sbjct: 281 VRQSANYTCVAMSTLGVI---EAIAQITVK-----------ALPKPPGTPV------VTE 320
Query: 2446 ATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTE 2505
+T TS+ + W + N Y +Q + +S + E+ + A+ Y V+ L PY++
Sbjct: 321 STATSITLTWDS---GNPEPVSYYIIQHKPKNSEELYKEI--DGVATTRYSVAGLSPYSD 375
Query: 2506 YMFRLVASNGFGSAHSSWIPFMTAEDKPGPVVPPILLDVKSRMM-----LVTWQHPRKSN 2560
Y FR+VA N G S P +T + P P DV++RM+ LV W+ P + N
Sbjct: 376 YEFRVVAVNNIGRGPPS-EPVLTQTSEQAPSSAP--RDVQARMLSSTTILVQWKEPEEPN 432
Query: 2561 GVITHYNIYLHGRLYLRTPGNVTN------------CTVMHLHPYTAYKFQVEACTSKGC 2608
G I Y +Y Y P N T+ +L P Y +V A TS G
Sbjct: 433 GQIQGYRVY-----YTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGD 487
Query: 2609 SLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEE 2668
V T G P + + ++ TS+++SW PP + + N+ + + G+
Sbjct: 488 GPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR--SDTIANYELVYK-DGEHG 544
Query: 2669 VTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQ 2728
+T+ S R L P + Y +R+ + G S+A + T S+P+
Sbjct: 545 EEQRITIEPGTSYRL----QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPS-AP 599
Query: 2729 PPVVTVLEPD--AVQVTWKPPLI--QNGDILSYEIHM-------PDPHITLTNVTSAVLS 2777
P ++ P ++ V+W+PP + QNG I Y I PH + + S
Sbjct: 600 PQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPH-EILGIPSDTTK 658
Query: 2778 QKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGP---LSVIPLSE 2834
+ L +T Y +T+ A + +G ESL + T+ VP GP + V ++
Sbjct: 659 YLLEQLEKWTEYRITVTAHTD----VGPGPESLSVLIRTNEDVPS--GPPRKVEVEAVNS 712
Query: 2835 SYVVISWQP--PSKPNGPNLRYEL--LRRKIQQPLASNPPEDLNRWHNIYSGTQWLYED- 2889
+ V +SW+ P+K +G Y++ +R + +P +D+ + + QW ++D
Sbjct: 713 TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDV-----MLADAQWEFDDT 767
Query: 2890 -------KGLSRFTTYEYMLFVHNSVG-FTPSREVTVTTLAGLPERGANLTASVLNHTAI 2941
GL T+Y + + + G S+ V+T +P + V+NHT +
Sbjct: 768 TEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGK----PRLVINHTQM 823
Query: 2942 D---VRWAKPTVQDLQGEVEYYTLFWSSATSN--DSLKILPDVNSHVIGHLKPNTEYWIF 2996
+ ++W P D G ++ Y L + +L+ + + Y
Sbjct: 824 NTALIQWHPPV--DTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFR 881
Query: 2997 ISVFN----GVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSP--SNPNGVV 3050
+S N G + + G PQ + ST+V++ W P + NG++
Sbjct: 882 LSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGT---TSTSVQLSWQPPVLAERNGII 938
Query: 3051 TEYSIYVNNKLYKTGMNVP------------GSFILRDLSPFTIYDIQVEVCT 3091
T+Y++ LY+ +N+P + L L P T YD++V T
Sbjct: 939 TKYTL-----LYR-DINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHT 985
Score = 114 bits (286), Expect = 2e-24
Identities = 197/794 (24%), Positives = 311/794 (39%), Gaps = 95/794 (11%)
Query: 4245 SAGHTC---SSWNVVR-----TLQAPPEGLSPPVISYVSMNPQKLLISWIPPEQSNGIIQ 4296
SA +TC S+ V+ T++A P+ PV++ + L PE + I
Sbjct: 284 SANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYII 343
Query: 4297 SYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTYSYALQACTS-GGCSTSKPTSITTLEAA 4355
++ + +E LY T Y+ L P+S Y + + A + G S+P T E A
Sbjct: 344 QHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQA 403
Query: 4356 PSEVSPPDLWA--VSATQMNVCWSPPTVQNGKITKYLVRYDN----------KESLAGQG 4403
PS +P D+ A +S+T + V W P NG+I Y V Y K ++A
Sbjct: 404 PSS-APRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQ 462
Query: 4404 LCLLVSHLQPYSQYNFSLVACTN-GGCTASVSKSAWTMEALPENMDSPTLQVTGSESIEI 4462
+ + +L P Y+ ++A T+ G S T +P + + SI +
Sbjct: 463 ITT-IGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILL 521
Query: 4463 TWKPPRNPNGQIRSYEL-RRDGTI-----VYTGLETRYRDFTLTPGVEYSYTVTASNSQG 4516
+W PPR+ I +YEL +DG + T YR L P Y + + A + QG
Sbjct: 522 SWTPPRSDT--IANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQG 579
Query: 4517 -GILSPLVKDRTSPSAPSGMEPPKLQARGPQE--ILVNWDPPV--RTNGDIINYTLFIRE 4571
G + + RT S PS P + P ILV+W PP + NG I Y++
Sbjct: 580 LGASTAEISARTMQSKPSA-PPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 638
Query: 4572 LFERETKIIHINTTHNSFGMQS----YIVNQLKPFHRYEIRIQACTTLGCASSDWT-FIQ 4626
+ + K H G+ S Y++ QL+ + Y I + A T +G + I+
Sbjct: 639 VDGEDDK------PHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIR 692
Query: 4627 TPEIAPLMQPPPHLEVQMAPGGFQPTVSLLWTGPL--QPNGKVLYYELYRRQIATQPRKS 4684
T E P PP +EV+ +V + W P+ + +G++ Y+++ ++ K
Sbjct: 693 TNEDVP-SGPPRKVEVEAVNS---TSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKG 748
Query: 4685 NPVL-----------IYNGSSTSFIDSELLPFTEYEYQVWAVNSAGK-APSSWTWCRTGP 4732
P+L + + I S L P T Y V A + G A S T
Sbjct: 749 QPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTG 808
Query: 4733 APPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTL 4792
A P R H +T A++ P G + YRL G + + E + T +
Sbjct: 809 AVPGKPRLVINHTQMNT-ALIQWHPPVDTFGPLQGYRL----KFGRKDM--EPLTTLEFS 861
Query: 4793 HGLQAFTNYSIGVEACTCFNCCSKGPTA-------ELRTHPAPPSGLSSP--QIGTLASR 4843
FT I A F ++ E+ P+G GT S
Sbjct: 862 EKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGT-TST 920
Query: 4844 TASFRWSPPMFP--NGVIHSYELQFHVACPPDSALPCTPSQIETKYTGLGQKASLGGLQP 4901
+ W PP+ NG+I Y L + D +P P +E +L GL+P
Sbjct: 921 SVQLSWQPPVLAERNGIITKYTLLYR-----DINIPLLP--MEQLIVPADTTMTLTGLKP 973
Query: 4902 YTTYKLRVVAHNEVG-STASEWISFTTQKELPQYRAPFSVDSNLSV-VCVNWSDTFLLNG 4959
TTY ++V AH G S + F T + F V + + V ++W N
Sbjct: 974 DTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNS 1033
Query: 4960 QLKEYVLTDGGRRV 4973
+ +L D G+ V
Sbjct: 1034 AMPFKILYDDGKMV 1047
Score = 110 bits (275), Expect = 4e-23
Identities = 181/769 (23%), Positives = 297/769 (38%), Gaps = 103/769 (13%)
Query: 3456 VNTYSYTDVNLKPYMTYEYRISAWNSYGRG-LSKAVRARTKEDVPQGVSPPTWTKIDNLE 3514
V T Y+ L PY YE+R+ A N+ GRG S+ V +T E P ++ +
Sbjct: 360 VATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLS-S 418
Query: 3515 DTIVLNWRKPIQSNGPI----IYYIL---------LRNGIERFRGTSLSFSDKEGIQPFQ 3561
TI++ W++P + NG I +YY + +++ + + T++ + P +
Sbjct: 419 TTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIG-----NLVPQK 473
Query: 3562 EYSYQLKACTVAGCA-TSSKVVAATTQGVPESILPPSITALSAVALHLSWSVPEKS---- 3616
YS ++ A T G SS + T GVP L S ++ LSW+ P
Sbjct: 474 TYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIAN 533
Query: 3617 -NGVIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGC-TSSEPFLG 3674
V K+ + + + I T+ R Q GL+P + Y F L A + G S+
Sbjct: 534 YELVYKDGEHGEEQRITIEPGTSYRLQ----GLKPNSLYYFRLAARSPQGLGASTAEISA 589
Query: 3675 QTLQAAPEGVWVTPRHIII---NSTTVELYWSLP--EKPNGLVSQYQLSRNG-------- 3721
+T+Q+ P P+ I +ST++ + W P EK NG++++Y +
Sbjct: 590 RTMQSKPS---APPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKP 646
Query: 3722 NLLFLGGSEEQNFTDKNLEPNSRYTYKLEVKTG-GGSSASDDYIVQTPMSTPEEIYPPYN 3780
+ + S+ + + LE + Y + T G S +++T P
Sbjct: 647 HEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVE 706
Query: 3781 ITVIGPYSIFVAWIPP----------GILIPEI----------PVEYNVLLNDGSVTPLA 3820
+ + S+ V+W P G + + P+ +V+L D
Sbjct: 707 VEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ---WE 763
Query: 3821 FSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSR-MFVKTPEAAPMDLNSPVLKALG 3879
F ++ L P T Y + + A G S+ V T A P +
Sbjct: 764 FDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQM 823
Query: 3880 SACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGD-----TLRP 3934
+ + I+W PP G + YR G ++ L LEF ++ D +
Sbjct: 824 NTAL-IQWHPPVDTFGPLQG---YRLKFGRKDMEPL-----TTLEFSEKEDHFTATDIHK 874
Query: 3935 FTLYEYRVRACNSKGSVESLWSLTQTLEAPPQDFPAP-WAQATSAHSVLLNWTKP--ESP 3991
Y +R+ A N G E + E P FP ++ T++ SV L+W P
Sbjct: 875 GASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAER 934
Query: 3992 NGIISHYRVVYQERPDDPTFNSPTV-HAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAG 4050
NGII+ Y ++Y++ N P + + L GL+P TTY + V A G
Sbjct: 935 NGIITKYTLLYRD------INIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRAHTSKG 988
Query: 4051 E-ILSPWTLIQTLESSPSGLRNFIVEQKENGRALLLQWSEPMRTNGVIKTYNIFSDGFL- 4108
SP +TL +NF V+ ++LL W P N + ++ DG +
Sbjct: 989 PGPYSPSVQFRTLPVDQVFAKNFHVKAVMK-TSVLLSWEIPENYNSAMPFKILYDDGKMV 1047
Query: 4109 -EYSGLNRQFLFRRLDPFTLYTLTLEACTRAGCAHSAPQPLWTDEAPPD 4156
E G Q L L P Y+ L T G + Q T + PD
Sbjct: 1048 EEVDGRATQKLIVNLKPEKSYSFVL---TNRGNSAGGLQHRVTAKTAPD 1093
Score = 106 bits (265), Expect = 5e-22
Identities = 173/765 (22%), Positives = 285/765 (37%), Gaps = 103/765 (13%)
Query: 4150 TDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADE 4209
T +A P P V +TS+ L+W + N + + Y +I Q +
Sbjct: 305 TVKALPKPPGTPVVTESTATSITLTWD---SGNPEPVSYYII-----------QHKPKNS 350
Query: 4210 KIVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVRTLQAPPEGLSPP 4269
+ ++ E + T Y+ GL P++ E+++ N+ G S V+ +P
Sbjct: 351 EELYKEIDGVATT-RYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPR 409
Query: 4270 VISYVSMNPQKLLISWIPPEQSNGIIQSYRLQ---------RNEMLYPFSFDPVTFNYTD 4320
+ ++ +L+ W PE+ NG IQ YR+ N M + + +T T
Sbjct: 410 DVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQIT---TI 466
Query: 4321 EELLPFSTYSYALQACTS-GGCSTSKPTSITTLEAAPSEVSPPDLWAVSATQMNVCWSPP 4379
L+P TYS + A TS G S + T P + S T + + W+PP
Sbjct: 467 GNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPP 526
Query: 4380 TVQNGKITKYLVRYDNKESLAGQ------GLCLLVSHLQPYSQYNFSLVACTNGGCTASV 4433
++ I Y + Y + E Q G + L+P S Y F L A + G AS
Sbjct: 527 --RSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGAST 584
Query: 4434 SK-SAWTMEALPENMDSPTLQVT----GSESIEITWKPP--RNPNGQIRSYELRRDGTIV 4486
++ SA TM++ P +P ++ S SI ++W+PP NG I Y ++
Sbjct: 585 AEISARTMQSKP---SAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK------ 635
Query: 4487 YTGLE----------------TRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDRTSP 4529
YT ++ T+Y L EY TVTA G G S V RT+
Sbjct: 636 YTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNE 695
Query: 4530 SAPSGMEPPK---LQARGPQEILVNWDPPV--RTNGDIINYTLFIRELFERETK------ 4578
PSG PP+ ++A + V+W PV + +G I Y + + E K
Sbjct: 696 DVPSG--PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLK 753
Query: 4579 ---IIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLG-CASSDWTFIQTPEIAPLM 4634
+ + I++ L+P Y + + A TT G A S + T P
Sbjct: 754 DVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVP-- 811
Query: 4635 QPPPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSS 4694
P L + T + W P+ G + + YR + + + L ++
Sbjct: 812 -GKPRLVINHTQ---MNTALIQWHPPVDTFGPL---QGYRLKFGRKDMEPLTTLEFSEKE 864
Query: 4695 TSFIDSELLPFTEYEYQVWAVNSAGKAPSSWTWCRTGPAPPEGLRAPTFHVISSTQAVVN 4754
F +++ Y +++ A N G P G H +T V
Sbjct: 865 DHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGF-PQNLHSEGTTSTSVQ 923
Query: 4755 IS----APGKPNGIVSLYRLFSSSAHGAETVLSEGMA---TQQTLHGLQAFTNYSIGVEA 4807
+S + NGI++ Y L + + + + T TL GL+ T Y + V A
Sbjct: 924 LSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPADTTMTLTGLKPDTTYDVKVRA 983
Query: 4808 CTCFNCCSKGPTAELRTHPAPPSGLSSPQIGTLASRTASFRWSPP 4852
T P+ + RT P + + + + W P
Sbjct: 984 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIP 1028
Score = 97.1 bits (240), Expect = 4e-19
Identities = 188/784 (23%), Positives = 316/784 (40%), Gaps = 86/784 (10%)
Query: 1920 GLQPFTEYLYRVIASHE-GGSVYSDWSRGRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEP 1978
GL P+++Y +RV+A + G S+ +T+ AP S P + R L+ +I V W EP
Sbjct: 369 GLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP 428
Query: 1979 -VVRGVIEKYILKAYSEDSTRPPRMPSASAEFVNTSNLTGILTGLLPFKNYAVTLTACTL 2037
G I+ Y + Y+ D T+ + + V S +T I L+P K Y+V + A T
Sbjct: 429 EEPNGQIQGYRV-YYTMDPTQ--HVNNWMKHNVADSQITTI-GNLVPQKTYSVKVLAFTS 484
Query: 2038 AGCTESSHALNISTPQEAPQEVQPPVAKSLP---SSLLLSWNPPKKANGIITQYCLYMDG 2094
G S + + T P QP K+ P +S+LLSW PP +++ I +Y DG
Sbjct: 485 IGDGPLSSDIQVITQTGVPG--QPLNFKAEPESETSILLSWTPP-RSDTIANYELVYKDG 541
Query: 2095 RLIYSGSEE--------NYTVTDLAVFTPHQFLLSACTHVGC-TNSSWVLLYTAQLPPEH 2145
G E+ +Y + L + + F L+A + G +++ + T Q P
Sbjct: 542 E---HGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSA 598
Query: 2146 VDSPV-LTVLDSRTIHIQWKQP--RKISGILERY-VLYMSNHTHDFTIWSVIYNSTELFQ 2201
+ T S +I + W+ P K +GI+ Y + Y + D ++ ++ +
Sbjct: 599 PPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTK 658
Query: 2202 DHMLQYVLPGNKYLIKLGACTGGGCTVSEASEAL-TDEDIPEGVPAP-KAHSYSPDSFNV 2259
++L+ + +Y I + A T G S + T+ED+P G P + + + S V
Sbjct: 659 -YLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKV 717
Query: 2260 SWTEPEYPN---GVITSYGLY--------------LDGILI-------HNSSELSYRAYG 2295
SW P PN G I Y ++ L +++ +++E G
Sbjct: 718 SWRSP-VPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISG 776
Query: 2296 FAPWSLHSFRVQACTAK--GCALGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPF 2353
P + +S V A T K G P + + T P G + + A ++W P
Sbjct: 777 LQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVP--GKPRLVINHTQMNTALIQWHPPV 834
Query: 2354 RPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVN 2413
G L L G ++P +T + +S +E + + +Y +++
Sbjct: 835 DTFGPLQGYRLKFGRKDMEP---------LTTLEFSEKEDHF--TATDIHKGASYVFRLS 883
Query: 2414 ISNSQGSLITDPITIAMPPGAPDGVLPPRLSS--ATPTSLQVVWSTPARNNAPG-SPRYQ 2470
N G I++P P G P L S T TS+Q+ W P G +Y
Sbjct: 884 ARNKVGFGEEMVKEISIPEEVPTG-FPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYT 942
Query: 2471 LQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSAHSSWIPFMTAE 2530
L R + +E P A + ++ L+P T Y ++ A G S P +
Sbjct: 943 LLYRDINIPLLPMEQLIVP-ADTTMTLTGLKPDTTYDVKVRAHTSKGPGPYS--PSVQFR 999
Query: 2531 DKPGPVVPPILLDVKSRM---MLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGNVTNCTV 2587
P V VK+ M +L++W+ P N + +Y G++ G T +
Sbjct: 1000 TLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLI 1059
Query: 2588 MHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPGAPEGI-PSPELFSDTPTSVIISWQP 2646
++L P +Y F T++G S V T AP+ + P T +I+ Q
Sbjct: 1060 VNLKPEKSYSF---VLTNRGNSAGGLQHRV-TAKTAPDVLRTKPAFIGKTNLDGMITVQL 1115
Query: 2647 PTHP 2650
P P
Sbjct: 1116 PEVP 1119
Score = 94.0 bits (232), Expect = 4e-18
Identities = 189/790 (23%), Positives = 289/790 (36%), Gaps = 77/790 (9%)
Query: 1949 TTGAAPQSVPTPSRVRSLNGYSIEVTWD----EPVVRGVIEKYILKAYSEDSTRPPRMPS 2004
T A P+ TP S SI +TWD EPV +I+ +P
Sbjct: 305 TVKALPKPPGTPVVTES-TATSITLTWDSGNPEPVSYYIIQH-----------KPKNSEE 352
Query: 2005 ASAEFVNTSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVA 2064
E + + GL P+ +Y + A G S + T ++AP V
Sbjct: 353 LYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQ 412
Query: 2065 KSLPSS--LLLSWNPPKKANGIITQYCLY--MDG-RLIYSGSEENY------TVTDLAVF 2113
+ SS +L+ W P++ NG I Y +Y MD + + + + N T+ +L
Sbjct: 413 ARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQ 472
Query: 2114 TPHQFLLSACTHVGCTN-SSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGI 2172
+ + A T +G SS + + T P + +I + W PR S
Sbjct: 473 KTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPR--SDT 530
Query: 2173 LERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACTGGGCTVSEAS 2232
+ Y L + H I T + LQ + P + Y +L A + G S A
Sbjct: 531 IANYELVYKDGEHGEEQRITIEPGTS----YRLQGLKPNSLYYFRLAARSPQGLGASTAE 586
Query: 2233 -EALTDEDIPEGVPAP-KAHSYSPDSFNVSWTEP--EYPNGVITSYGLY---LDG----- 2280
A T + P P S S S VSW P E NG+IT Y + +DG
Sbjct: 587 ISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKP 646
Query: 2281 --ILIHNSSELSYRAYGFAPWSLHSFRVQACTAKGCALGPL-VENRTLEAPPEGTVN-VF 2336
IL S Y W+ + V A T G L V RT E P G V
Sbjct: 647 HEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVE 706
Query: 2337 VKTQGSRKAHVRWEAPFRPNG----LLTHSVLFTGIFYVDPVGNNYTL-LNVTKVMYSGE 2391
V+ S V W +P PN + + V + + +P G + + + +
Sbjct: 707 VEAVNSTSVKVSWRSPV-PNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFD 765
Query: 2392 ETNLW-VLIDGLVPFTNYTVQVNISNSQGSLITDPITIAMPPGAPDGVLPPRLSSATPTS 2450
+T ++I GL P T+Y++ V ++G + GA G ++ +
Sbjct: 766 DTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNT 825
Query: 2451 LQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRL 2510
+ W P P Y+L+ D FS + +D+ Y+FRL
Sbjct: 826 ALIQWHPPVDTFGP-LQGYRLKFGRKDMEPLTTLEFSEKEDH--FTATDIHKGASYVFRL 882
Query: 2511 VASNGFGSAHSSWIPFMTAEDKPGPVVPPILLD-VKSRMMLVTWQHP--RKSNGVITHY- 2566
A N G E+ P + + S + ++WQ P + NG+IT Y
Sbjct: 883 SARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGIITKYT 942
Query: 2567 ------NIYLHGRLYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTL 2620
NI L L P + T T+ L P T Y +V A TSKG S TL
Sbjct: 943 LLYRDINIPLLPMEQLIVPADTT-MTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTL 1001
Query: 2621 PGAPEGIPSPELFSDTPTSVIISWQPPTHPNG------LVENFTIERRVKGKEEVTTLVT 2674
P + + + TSV++SW+ P + N L ++ + V G+ +V
Sbjct: 1002 PVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVN 1061
Query: 2675 LPRSHSMRFI 2684
L S F+
Sbjct: 1062 LKPEKSYSFV 1071
Score = 82.4 bits (202), Expect = 1e-14
Identities = 114/461 (24%), Positives = 186/461 (40%), Gaps = 62/461 (13%)
Query: 1055 FQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDTD 1114
F PP ++ ++N++ SP + Y G E T ED P D
Sbjct: 225 FSIPPTNHEIMPGGSVNITCVAVGSP----MPYVKWMLGAEDLTPEDDMPIGRNVLELND 280
Query: 1115 LLPYTKYSYYIETTNVHGSTRSVA-VTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLS 1173
+ Y+ +T G ++A +T K P P + + + S+TLTW S
Sbjct: 281 VRQSANYTCVAMSTL--GVIEAIAQITVKALPKPPGTPV----VTESTATSITLTWD--S 332
Query: 1174 NQSGPIEKYILSCAPLAGGQPCVSYEGHETSA-TIWNLVPFAKYDFSVQACTS-GGCLHS 1231
P+ YI+ P + +G T+ ++ L P++ Y+F V A + G S
Sbjct: 333 GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPS 392
Query: 1232 LPI-TVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETT 1290
P+ T T+ QAP + + +SST + V+W P E NG I Y +Y T + T
Sbjct: 393 EPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYY-----TMDPT 447
Query: 1291 SEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SVS 1349
+ W+ H+ +S +TTI L P Y +VLA G
Sbjct: 448 Q------HVNNWMK-HNVADS----------QITTIGNLVPQKTYSVKVLAFTSIGDGPL 490
Query: 1350 SAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKP-ADNVTRGKVVGYDINMLSEQSPQ 1408
S+ + T P + P S S+ +SW P +D + ++V D E +
Sbjct: 491 SSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKD----GEHGEE 546
Query: 1409 QSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGC-VTSASGAGQTLAAAP 1467
Q I + SY ++GLKP +Y F + + G ++A + +T+ + P
Sbjct: 547 QRITI----------EPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKP 596
Query: 1468 AQLRPP---LVKGINSTTIHLKWFPP--EELNGPSPIYQLE 1503
+ PP +ST+I + W PP E+ NG Y ++
Sbjct: 597 S--APPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIK 635
Score = 81.6 bits (200), Expect = 2e-14
Identities = 121/486 (24%), Positives = 184/486 (37%), Gaps = 72/486 (14%)
Query: 1061 RGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLDT------- 1113
+ ++ SS+ I + W P+ PN G+ +Y T D + +
Sbjct: 412 QARMLSSTTILVQWKEPEEPNGQI-------QGYRVYYTMDPTQHVNNWMKHNVADSQIT 464
Query: 1114 ---DLLPYTKYSYYIET-TNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTW 1169
+L+P YS + T++ S + T+ GVP L P S+ L+W
Sbjct: 465 TIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFK-AEPESETSILLSW 523
Query: 1170 TTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGGC- 1228
T +S I Y L G+ TS + L P + Y F + A + G
Sbjct: 524 TP--PRSDTIANYELVYKDGEHGEEQRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLG 581
Query: 1229 LHSLPITVTTAQ----APPQRLSPPKMQKISSTELHVEWSPPA--ELNGIIIRYELYMRR 1282
+ I+ T Q APPQ +S SST + V W PP + NGII Y +
Sbjct: 582 ASTAEISARTMQSKPSAPPQDIS---CTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTA 638
Query: 1283 LRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAV 1342
+ + PH + ++ T + LE +T+Y V A
Sbjct: 639 VDGEDD---------------KPHEILGIPSDT------TKYLLEQLEKWTEYRITVTAH 677
Query: 1343 NMAG-SVSSAWVSERTGESAPVFMIPP---SVFPLSSYSLNISWEKPADNVTRGKVVGYD 1398
G S V RT E P PP V ++S S+ +SW P N G++ GY
Sbjct: 678 TDVGPGPESLSVLIRTNEDVPSG--PPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQ 735
Query: 1399 INML-SEQSPQQSIPMAFSQLLHTAK-----SQELSYTVEGLKPYRIYEFTITLCNSVG- 1451
++ + E + PM +L A+ + E + GL+P Y T+T + G
Sbjct: 736 VHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGD 795
Query: 1452 CVTSASGAGQTLAAAPAQLRPPLVKGINST---TIHLKWFPPEELNGPSPIYQLERRESS 1508
S T A P +P LV IN T T ++W PP + GP Y+L+
Sbjct: 796 GARSKPKLVSTTGAVPG--KPRLV--INHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKD 851
Query: 1509 LPALMT 1514
+ L T
Sbjct: 852 MEPLTT 857
Score = 66.2 bits (160), Expect = 8e-10
Identities = 113/473 (23%), Positives = 179/473 (37%), Gaps = 85/473 (17%)
Query: 1066 SSSAINLSWSPP--DSPNAHWLTYSLLRDGFEIYTTEDQYPYSI--------QYFLDTDL 1115
SS++I +SW PP + N YS+ + ED P+ I +Y L+ L
Sbjct: 609 SSTSILVSWQPPPVEKQNGIITEYSIK---YTAVDGEDDKPHEILGIPSDTTKYLLE-QL 664
Query: 1116 LPYTKYSYYIET-TNVHGSTRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTL-- 1172
+T+Y + T+V S++V +T VP G + + S SV ++W +
Sbjct: 665 EKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVP 724
Query: 1173 SNQSGPIEKYILSCAPLAGGQPC------------VSYEGHETSA---TIWNLVPFAKYD 1217
+ Q G I Y + + G+P +E +T+ I L P Y
Sbjct: 725 NKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYS 784
Query: 1218 FSVQACTS-GGCLHSLPITVTTAQAPPQRLSPPKMQKISSTELH---VEWSPPAELNGII 1273
+V A T+ G S P V+T A P + P++ I+ T+++ ++W PP + G +
Sbjct: 785 LTVTAYTTKGDGARSKPKLVSTTGAVPGK---PRLV-INHTQMNTALIQWHPPVDTFGPL 840
Query: 1274 IRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYT 1333
Y L R TT E S + T T +
Sbjct: 841 QGYRLKFGRKDMEPLTTLEFSE------------------------KEDHFTATDIHKGA 876
Query: 1334 KYEFRVLAVNMAGSVSSAWVSERTGESAPVFMIPPSVFP-------LSSYSLNISWEKPA 1386
Y FR+ A N G E + + P+ FP +S S+ +SW+ P
Sbjct: 877 SYVFRLSARNKVG------FGEEMVKEISIPEEVPTGFPQNLHSEGTTSTSVQLSWQPPV 930
Query: 1387 DNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITL 1446
G + Y + P +PM QL+ A + + T+ GLKP Y+ +
Sbjct: 931 LAERNGIITKYTLLYRDINIP--LLPM--EQLIVPA---DTTMTLTGLKPDTTYDVKVRA 983
Query: 1447 CNSVG-CVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSP 1498
S G S S +TL + VK + T++ L W PE N P
Sbjct: 984 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMP 1036
Score = 46.2 bits (108), Expect = 8e-04
Identities = 96/397 (24%), Positives = 145/397 (36%), Gaps = 70/397 (17%)
Query: 1115 LLPYTKYSYYIETTNVHGS-TRSVAVTYKTKPGVP-EGNLTLSYIIPIGSDSVTLTWTTL 1172
L P T YS + G RS T VP + L +++ ++ + W
Sbjct: 777 LQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHT---QMNTALIQWHPP 833
Query: 1173 SNQSGPIEKYILSCA-----PLAGGQPCVSYEGHETSATIWNLVPFAKYDFSVQACTSGG 1227
+ GP++ Y L PL + + E T ++ A Y F + A G
Sbjct: 834 VDTFGPLQGYRLKFGRKDMEPLT----TLEFSEKEDHFTATDIHKGASYVFRLSARNKVG 889
Query: 1228 ----CLHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPP--AELNGIIIRYELYMR 1281
+ + I PQ L + +ST + + W PP AE NGII +Y L R
Sbjct: 890 FGEEMVKEISIPEEVPTGFPQNLHS---EGTTSTSVQLSWQPPVLAERNGIITKYTLLYR 946
Query: 1282 RLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLA 1341
+ L P E + P T T+TGL+P T Y+ +V A
Sbjct: 947 DINIP----------------LLPM-------EQLIVPADTTMTLTGLKPDTTYDVKVRA 983
Query: 1342 VNMAG-SVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPAD-NVTRGKVVGYDI 1399
G S V RT VF V + S+ +SWE P + N + YD
Sbjct: 984 HTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDD 1043
Query: 1400 NMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTIT-LCNSVGCV---TS 1455
+ E+ ++ +Q+L + LKP + Y F +T NS G + +
Sbjct: 1044 GKMVEEVDGRA-------------TQKL---IVNLKPEKSYSFVLTNRGNSAGGLQHRVT 1087
Query: 1456 ASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEE 1492
A A L PA + + G+ T+ L P E
Sbjct: 1088 AKTAPDVLRTKPAFIGKTNLDGM--ITVQLPEVPANE 1122
Score = 43.5 bits (101), Expect = 0.005
Identities = 30/93 (32%), Positives = 47/93 (50%), Gaps = 12/93 (12%)
Query: 4895 SLGGLQPYTTYKLRVVAHNEVG-STASEWISFTTQKELPQYRAPFSVDSNL---SVVCVN 4950
S+ GL PY+ Y+ RVVA N +G SE + T ++ P AP V + + + + V
Sbjct: 366 SVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPS-SAPRDVQARMLSSTTILVQ 424
Query: 4951 WSDTFLLNGQLKEYVLTDGGRRVYSGLDTTLYI 4983
W + NGQ++ Y RVY +D T ++
Sbjct: 425 WKEPEEPNGQIQGY-------RVYYTMDPTQHV 450
Score = 41.2 bits (95), Expect = 0.027
Identities = 38/138 (27%), Positives = 62/138 (44%), Gaps = 11/138 (7%)
Query: 3026 PEVVIINSTAVRVIWTSPSNPNGV---VTEYSIYVNNKLYKTGMNVPGS-FILRDLSPFT 3081
P V +T++ + W S NP V + ++ + +LYK V + + + LSP++
Sbjct: 316 PVVTESTATSITLTWDS-GNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYS 374
Query: 3082 IYDIQV-EVCTIYACVKSNGTQITTVEDTPSDIPTPT-IRGITSRSLQIDWVSPRKPNGI 3139
Y+ +V V I S T E PS P R ++S ++ + W P +PNG
Sbjct: 375 DYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQ 434
Query: 3140 ILGYDLLWKTWYPCAKTQ 3157
I GY + +Y TQ
Sbjct: 435 IQGY----RVYYTMDPTQ 448
>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
Length = 1140
Score = 146 bits (369), Expect = 5e-34
Identities = 175/670 (26%), Positives = 234/670 (34%), Gaps = 199/670 (29%)
Query: 515 SGRCQCHGHADNCDTTSQPYRCLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNC-K 573
S CQCH + CD + +C CS G +RC ++ P Y C +
Sbjct: 278 SQECQCH-NGGTCDAATG--QCHCSP-----GYTGERC---QDECPVG----TYGVLCAE 322
Query: 574 PCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDDCEHNTTGRNCE--LCKDYFFRQVGAD 631
CQC + K H + G C CE G CE LC + +
Sbjct: 323 TCQCVNGGKCYHVS---------------GACL-CEAGFAGERCEARLCPEGLY------ 360
Query: 632 PSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQ-CQNGFY--------- 681
I K C C T + C + G+C CK SG CN+ C GFY
Sbjct: 361 --GIKCDKRCPCHLENTHS----CHPMSGECACKPGWSGLYCNETCSPGFYGEACQQICS 414
Query: 682 --NLQELDP--------------DGCSPC-------NCNTSGTVDGDITCHQNSGQCKCK 718
N + D D +PC NC++ D C G C CK
Sbjct: 415 CQNGADCDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCK 474
Query: 719 ANVIG----LRCDHCNFGFKFLRSFNDVGCE-PCQCNLHGSVNKFCNPHSGQCECKKEAK 773
A G +RC +GF GC CQC L+G CN G C C +
Sbjct: 475 AGWHGVDCSIRCPSGTWGF---------GCNLTCQC-LNGGA---CNTLDGTCTCAPGWR 521
Query: 774 GLQCDT-CRENFYGLDVTNC-KACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNK-CL 830
G +C+ C++ YGL NC + CDC A C+ TG C C P G C+ C
Sbjct: 522 GEKCELPCQDGTYGL---NCAERCDCSHADG-----CHPTTGHCRCLPGWSGVHCDSVCA 573
Query: 831 EGNF--------YLRQNNSF--------------------LCLP------CNCDKTGTIN 856
EG + Y + S +C P C+ ++
Sbjct: 574 EGRWGPNCSLPCYCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVH 633
Query: 857 GSLLCNKSTGQCPCKLGVTGLRCNQ-CEPHRYNLTIDNFQHC----------QMCEC--- 902
S C+ TG C C G TG CN+ C R+ C + C+C
Sbjct: 634 SSGPCHHITGLCDCLPGFTGALCNEVCPSGRFGKNCAGICTCTNNGTCNPIDRSCQCYPG 693
Query: 903 ----DSLGTLP----------------GTICDPISGQCLCVPNRQGRRCNQ-CQPGFYIS 941
D P G C G+C C P G C Q C GFY
Sbjct: 694 WIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLGFY-- 751
Query: 942 PGNATGCLPCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQ-CKDHYFGFDPQTGRCQ 1000
L C C +HI +GQC C+ G+ C+Q C +G+ G Q
Sbjct: 752 --GKDCALICQCQNGADCDHI----SGQCTCR-TGFMGRHCEQKCPSGTYGY----GCRQ 800
Query: 1001 PCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVPSASHLDVNNLLGCSKTPFQQPPP 1060
C+C N TC +TG C+C G++CD A + V NL S+T P
Sbjct: 801 ICDC----LNNSTCDHITGTCYCSPGWKGARCD----QAGVIIVGNLNSLSRTSTALPAD 852
Query: 1061 RGQVQSSSAI 1070
Q+ + + I
Sbjct: 853 SYQIGAIAGI 862
Score = 138 bits (348), Expect = 1e-31
Identities = 131/507 (25%), Positives = 187/507 (36%), Gaps = 145/507 (28%)
Query: 577 CNSHSKSCHYNISVDPFPFEHFRGGGGVCDD-CEHNTTGRNCELCKDYFFRQVGADPSAI 635
CN + +CH FRG C+D CE T G +C
Sbjct: 160 CNPITGACHCAAG--------FRGWR--CEDRCEQGTYGNDCH----------------- 192
Query: 636 DVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQ-CQNGFYNLQELDPDGCSPC 694
+ C C T CD + G+C C +G C C G + P C
Sbjct: 193 ---QRCQCQNGAT------CDHVTGECRCPPGYTGAFCEDLCPPGKHG-----PQCEQRC 238
Query: 695 NCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDH-CNFGFKFLRSFNDVGCEPCQCNLHG 753
C G CH +G+C C + +G C C G F + CQC+ G
Sbjct: 239 PCQNGG------VCHHVTGECSCPSGWMGTVCGQPCPEG-----RFGKNCSQECQCHNGG 287
Query: 754 SVNKFCNPHSGQCECKKEAKGLQC-DTCRENFYGLDVTNCKACDCDTAGSLPGTVCNAKT 812
+ C+ +GQC C G +C D C YG V + C C G C +
Sbjct: 288 T----CDAATGQCHCSPGYTGERCQDECPVGTYG--VLCAETCQCVNGGK-----CYHVS 336
Query: 813 GQCICKPNVEGRQCNK--CLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPC 870
G C+C+ G +C C EG + ++ + PC+ + T + C+ +G+C C
Sbjct: 337 GACLCEAGFAGERCEARLCPEGLYGIKCDKR---CPCHLENTHS------CHPMSGECAC 387
Query: 871 KLGVTGLRCNQ-CEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGR 929
K G +GL CN+ C P Y Q+C C + G CD ++G+C C P +G
Sbjct: 388 KPGWSGLYCNETCSPGFYGEACQ-----QICSCQN-----GADCDSVTGKCTCAPGFKGI 437
Query: 930 RCN-QCQPGFY-ISPGNATGC--------------------------------------L 949
C+ C G Y I+ + GC L
Sbjct: 438 DCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGSCTCKAGWHGVDCSIRCPSGTWGFGCNL 497
Query: 950 PCSCHTTGAVNHICNSLTGQCVCQDASIAGQRCD-QCKDHYFGFDPQTGRCQPCNC-HLS 1007
C C GA CN+L G C C G++C+ C+D +G + + C+C H
Sbjct: 498 TCQCLNGGA----CNTLDGTCTCA-PGWRGEKCELPCQDGTYGLN----CAERCDCSHAD 548
Query: 1008 GALNETCHLVTGQCFCKQFVTGSKCDA 1034
G CH TG C C +G CD+
Sbjct: 549 G-----CHPTTGHCRCLPGWSGVHCDS 570
Score = 132 bits (332), Expect = 9e-30
Identities = 129/445 (28%), Positives = 170/445 (38%), Gaps = 92/445 (20%)
Query: 608 CEHNTTGRNCELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRH 667
CE G NC D D C C +NG+ LC+ I G C+C
Sbjct: 126 CEPGWGGTNCSSACD-------GDHWGPHCTSRCQC-----KNGA-LCNPITGACHCAAG 172
Query: 668 VSGRQC-NQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRC 726
G +C ++C+ G Y D C C TC +G+C+C G C
Sbjct: 173 FRGWRCEDRCEQGTYG-----NDCHQRCQCQNGA------TCDHVTGECRCPPGYTGAFC 221
Query: 727 -DHCNFGFKFLRSFNDVGCE---PCQCNLHGSVNKFCNPHSGQCECKKEAKGLQC-DTCR 781
D C G + CE PCQ +G V C+ +G+C C G C C
Sbjct: 222 EDLCPPG------KHGPQCEQRCPCQ---NGGV---CHHVTGECSCPSGWMGTVCGQPCP 269
Query: 782 ENFYGLDVTNC-KACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQC-NKCLEGNFYLRQN 839
E +G NC + C C G+ C+A TGQC C P G +C ++C G +
Sbjct: 270 EGRFG---KNCSQECQCHNGGT-----CDAATGQCHCSPGYTGERCQDECPVGTY----- 316
Query: 840 NSFLCL-PCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQ--CEPHRYNLTIDNFQH 896
LC C C +NG C +G C C+ G G RC C Y + D
Sbjct: 317 -GVLCAETCQC-----VNGG-KCYHVSGACLCEAGFAGERCEARLCPEGLYGIKCD---- 365
Query: 897 CQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQ-CQPGFYISPGNATGCLPCSCHT 955
+ C C T C P+SG+C C P G CN+ C PGFY G A + CSC
Sbjct: 366 -KRCPCHLENT---HSCHPMSGECACKPGWSGLYCNETCSPGFY---GEACQQI-CSCQ- 416
Query: 956 TGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALNETCH 1015
GA C+S+TG+C C C +G + C+ + C
Sbjct: 417 NGA---DCDSVTGKCTCAPGFKGIDCSTPCPLGTYGIN--------CSSRCGCKNDAVCS 465
Query: 1016 LVTGQCFCKQFVTGSKCDACVPSAS 1040
V G C CK G C PS +
Sbjct: 466 PVDGSCTCKAGWHGVDCSIRCPSGT 490
Score = 124 bits (312), Expect = 2e-27
Identities = 117/436 (26%), Positives = 166/436 (38%), Gaps = 81/436 (18%)
Query: 662 CNCKRHVSGRQCNQCQNGFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANV 721
C C+ G C+ +G P S C C C+ +G C C A
Sbjct: 124 CQCEPGWGGTNCSSACDG----DHWGPHCTSRCQCKNGAL------CNPITGACHCAAGF 173
Query: 722 IGLRC-DHCNFGFKFLRSFNDVGCEPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQC-DT 779
G RC D C G ++ + + CQC +G+ C+ +G+C C G C D
Sbjct: 174 RGWRCEDRCEQG-----TYGNDCHQRCQCQ-NGAT---CDHVTGECRCPPGYTGAFCEDL 224
Query: 780 CRENFYGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNK-CLEGNFYLRQ 838
C +G + C C G VC+ TG+C C G C + C EG F
Sbjct: 225 CPPGKHGPQCE--QRCPCQNGG-----VCHHVTGECSCPSGWMGTVCGQPCPEGRFGKNC 277
Query: 839 NNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRC-NQCEPHRYNLTIDNFQHC 897
+ C C GT C+ +TGQC C G TG RC ++C Y +
Sbjct: 278 SQE-----CQCHNGGT------CDAATGQCHCSPGYTGERCQDECPVGTYGVLC-----A 321
Query: 898 QMCECDSLGTLPGTICDPISGQCLCVPNRQGRRCNQ--CQPGFYISPGNATGC-LPCSCH 954
+ C+C + G C +SG CLC G RC C G Y C C CH
Sbjct: 322 ETCQC-----VNGGKCYHVSGACLCEAGFAGERCEARLCPEGLY-----GIKCDKRCPCH 371
Query: 955 TTGAVNHICNSLTGQCVCQDASIAGQRCDQ-CKDHYFGFDPQTGRCQPCNCHLSGALNET 1013
H C+ ++G+C C+ +G C++ C ++G Q Q C+C +GA
Sbjct: 372 LEN--THSCHPMSGECACK-PGWSGLYCNETCSPGFYGEACQ----QICSCQ-NGA---D 420
Query: 1014 CHLVTGQCFCKQFVTGSKCDACVPSASH-LDVNNLLGCSKTPFQQPPPRGQVQSSSAINL 1072
C VTG+C C G C P ++ ++ ++ GC P V S
Sbjct: 421 CDSVTGKCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSP-----VDGSCTCKA 475
Query: 1073 SWSPPD----SPNAHW 1084
W D P+ W
Sbjct: 476 GWHGVDCSIRCPSGTW 491
Score = 51.2 bits (121), Expect = 3e-05
Identities = 47/151 (31%), Positives = 58/151 (38%), Gaps = 47/151 (31%)
Query: 929 RRCNQCQPGFYIS-----PGNATGCL--------PCSC--------------------HT 955
RR +QC PGFY S P A C+ C C H
Sbjct: 89 RRKSQCCPGFYESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNCSSACDGDHWGPHC 148
Query: 956 TGAV----NHICNSLTGQCVCQDASIAGQRC-DQCKDHYFGFDPQTGRCQPCNCHLSGAL 1010
T +CN +TG C C A G RC D+C+ +G D Q C C +GA
Sbjct: 149 TSRCQCKNGALCNPITGACHCA-AGFRGWRCEDRCEQGTYGNDCH----QRCQCQ-NGA- 201
Query: 1011 NETCHLVTGQCFCKQFVTGSKCDACVPSASH 1041
TC VTG+C C TG+ C+ P H
Sbjct: 202 --TCDHVTGECRCPPGYTGAFCEDLCPPGKH 230
>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
sapiens]
Length = 1037
Score = 146 bits (368), Expect = 6e-34
Identities = 168/630 (26%), Positives = 214/630 (33%), Gaps = 199/630 (31%)
Query: 517 RCQCHGHADNCDTTSQPYRCLCSQESF-----------TEGLHCDRCLPLYNDKPFR--Q 563
RCQCHG CD Q C C E T G C N F+ Q
Sbjct: 190 RCQCHGAP--CDP--QTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQ 245
Query: 564 GD------QVYAFNCKPCQCNSHSKSCHYNISVDPFPFEHFRGGGGVCDD------CEHN 611
G + PC H +C GG+CD C
Sbjct: 246 GSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCH---------NGGLCDRFTGQCRCAPG 296
Query: 612 TTGRNC-ELCKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSG 670
TG C E C F Q D + CDC C G C C+ +G
Sbjct: 297 YTGDRCREECPVGRFGQ--------DCAETCDCAP------DARCFPANGACLCEHGFTG 342
Query: 671 RQCNQ--CQNGFYNLQELDPDGC-SPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCD 727
+C C +GFY L C +PC C+ + ++CH +G+C C GL
Sbjct: 343 DRCTDRLCPDGFYGLS------CQAPCTCDR----EHSLSCHPMNGECSCLPGWAGL--- 389
Query: 728 HCNFGFKFLRSFNDVGC-EPCQCNLHGSVNKFCNPHSGQCECKKEAKGLQCDT-CRENFY 785
HCN + + GC E C C LHG V C SG C+C G C + C + Y
Sbjct: 390 HCNESCP--QDTHGPGCQEHCLC-LHGGV---CQATSGLCQCAPGYTGPHCASLCPPDTY 443
Query: 786 GLDVTNCKA-CDCDTAGSL-----------------------PGT--------------- 806
G+ NC A C C+ A + PGT
Sbjct: 444 GV---NCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEA 500
Query: 807 VCNAKTGQCICKPNVEGRQCN-KCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKST 865
VC+ +TG C C P G C C +G F C+CD + C+
Sbjct: 501 VCSPQTGACTCTPGWHGAHCQLPCPKGQF-----GEGCASRCDCDHSDG------CDPVH 549
Query: 866 GQCPCKLGVTGLRCN-QCEPHRYNLTIDNFQHCQMCECDSLGTLPGTICDPISGQCLCVP 924
G+C C+ G G RC+ C + + N C C + GT C P +G C+C P
Sbjct: 550 GRCQCQAGWMGARCHLSCPEGLWGVNCSN-----TCTCKNGGT-----CLPENGNCVCAP 599
Query: 925 NRQGRRCNQ-CQPGFYISPGNATGCLPCSCHTTGAVNH-ICNSLTGQCVCQDASIAGQRC 982
+G C + CQPG Y C+PC C NH C+ G C C A G C
Sbjct: 600 GFRGPSCQRSCQPGRY-----GKRCVPCKC-----ANHSFCHPSNGTCYCL-AGWTGPDC 648
Query: 983 DQ--------------CKDHYFGF-DPQTGRC-------------------------QPC 1002
Q C+ H+ G PQ G C QPC
Sbjct: 649 SQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPC 708
Query: 1003 NCHLSGALNETCHLVTGQCFCKQFVTGSKC 1032
C E CH TG C C +G+ C
Sbjct: 709 QC----GPGEKCHPETGACVCPPGHSGAPC 734
Score = 128 bits (321), Expect = 2e-28
Identities = 146/584 (25%), Positives = 204/584 (34%), Gaps = 142/584 (24%)
Query: 518 CQCHGHADNCDTTSQPYRCLCSQESFTEGLHC-DRCLPLYNDKPFRQGDQVYAFNCKP-- 574
C C G+ +CD P +CS S + +C C P Y + Q + C P
Sbjct: 148 CSC-GNNSSCD----PKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQT 202
Query: 575 --CQCNSHSK------SCHYNISVDPFPFEHFRGGGGVCD------DCEHNTTGRNCEL- 619
C C + SC S P H GGV C G C L
Sbjct: 203 GACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLP 262
Query: 620 CKDYFFRQVGADPSAIDVCKPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQ-CQN 678
C + F + + C C G LCD+ GQC C +G +C + C
Sbjct: 263 CPEGFHGP--------NCSQECRCHNGG------LCDRFTGQCRCAPGYTGDRCREECPV 308
Query: 679 GFYNLQELDPDGCSPCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCDH--CNFGFKFL 736
G + + C+P D C +G C C+ G RC C GF L
Sbjct: 309 GRFGQDCAETCDCAP-----------DARCFPANGACLCEHGFTGDRCTDRLCPDGFYGL 357
Query: 737 RSFNDVGCE-PCQCNLHGSVNKFCNPHSGQCECKKEAKGLQC-DTCRENFYGLDVTNCKA 794
C+ PC C+ S++ C+P +G+C C GL C ++C ++ +G C+
Sbjct: 358 ------SCQAPCTCDREHSLS--CHPMNGECSCLPGWAGLHCNESCPQDTHG---PGCQE 406
Query: 795 -CDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNKCLEGNFYLRQNNSFLCLPCNCDKTG 853
C C L G VC A +G C C P G C + Y NC
Sbjct: 407 HCLC-----LHGGVCQATSGLCQCAPGYTGPHCASLCPPDTY----------GVNCSARC 451
Query: 854 TINGSLLCNKSTGQCPCKLGVTGLRCN-QCEPHRYNLTIDNFQHCQMCECDSLGTLPGTI 912
+ ++ C+ G+C CK G C+ C P + + + C+C +
Sbjct: 452 SCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCN-----ASCQCAH-----EAV 501
Query: 913 CDPISGQCLCVPNRQGRRCNQCQPGFYISPGNATGCLPCSCHTTGAVNHICNSLTGQCVC 972
C P +G C C P G C P G A+ C C H+ G C+ + G+C C
Sbjct: 502 CSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRC-DCD-HSDG-----CDPVHGRCQC 554
Query: 973 QDASIAGQRCD-QCKDHYFGFD--------------PQTG-------------------- 997
Q A G RC C + +G + P+ G
Sbjct: 555 Q-AGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPG 613
Query: 998 ----RCQPCNCHLSGALNETCHLVTGQCFCKQFVTGSKCDACVP 1037
RC PC C A + CH G C+C TG C P
Sbjct: 614 RYGKRCVPCKC----ANHSFCHPSNGTCYCLAGWTGPDCSQPCP 653
Score = 118 bits (296), Expect = 1e-25
Identities = 122/466 (26%), Positives = 155/466 (33%), Gaps = 120/466 (25%)
Query: 639 KPCDCDTVGTRNGSILCDQIGGQCNCKRHVSGRQCNQ-CQNGFYNLQELDPDGCSPCNCN 697
KPC C N S CD G C+C + C Q C G+Y P C C+
Sbjct: 146 KPCSCGN----NSS--CDPKSGVCSCPSGLQPPNCLQPCTPGYYG-----PACQFRCQCH 194
Query: 698 TSGTVDGDITCHQNSGQCKCKANVIGLRCD----------------HCNFGFKFLRSFND 741
+ C +G C C A G CD C G F
Sbjct: 195 GA-------PCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGS 247
Query: 742 VGCEP-----------------------CQCNLHGSVNKFCNPHSGQCECKKEAKGLQCD 778
C P C+C+ G C+ +GQC C A G D
Sbjct: 248 CSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGG----LCDRFTGQCRC---APGYTGD 300
Query: 779 TCRENF----YGLDVTNCKACDCDTAGSLPGTVCNAKTGQCICKPNVEGRQCNK--CLEG 832
CRE +G D + CDC P C G C+C+ G +C C +G
Sbjct: 301 RCREECPVGRFGQDC--AETCDC-----APDARCFPANGACLCEHGFTGDRCTDRLCPDG 353
Query: 833 NFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKLGVTGLRCNQCEPHRYNLTID 892
+ L PC CD+ SL C+ G+C C G GL CN+ P
Sbjct: 354 FYGLSCQ-----APCTCDR----EHSLSCHPMNGECSCLPGWAGLHCNESCPQD------ 398
Query: 893 NFQHCQMCECDSLGTLPGTICDPISGQCLCVPNRQGRRC-NQCQPGFYISPGNATGCLPC 951
H C+ L L G +C SG C C P G C + C P Y C
Sbjct: 399 --THGPGCQEHCL-CLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTY----GVNCSARC 451
Query: 952 SCHTTGAVNHICNSLTGQCVCQDASIAGQRCDQCKDHYFGFDPQTGRCQPCNCHLSGALN 1011
SC A C+ + G+CVC++ G C +GF CN A
Sbjct: 452 SCENAIA----CSPIDGECVCKEGWQRGNCSVPCPPGTWGFS--------CNASCQCAHE 499
Query: 1012 ETCHLVTGQCFCKQFVTGSKCDACVPS-------ASHLDVNNLLGC 1050
C TG C C G+ C P AS D ++ GC
Sbjct: 500 AVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGC 545
Score = 114 bits (284), Expect = 3e-24
Identities = 124/491 (25%), Positives = 170/491 (34%), Gaps = 133/491 (27%)
Query: 536 CLCSQESFTEGLHCDRCLPLYNDKPFRQGDQVYAFNCK-PCQCN-SHSKSCH-YNISVDP 592
CLC + FT DR P D Y +C+ PC C+ HS SCH N
Sbjct: 334 CLC-EHGFTGDRCTDRLCP----------DGFYGLSCQAPCTCDREHSLSCHPMNGECSC 382
Query: 593 FPFEHFRGGGGV-CDD-CEHNTTGRNCELCKDYFFRQVGADPSAIDVCKP---------- 640
P G G+ C++ C +T G C+ V S + C P
Sbjct: 383 LP-----GWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASL 437
Query: 641 CDCDTVGTR-------NGSILCDQIGGQCNCKRHVSGRQCN-QCQNGFYNLQELDPDGCS 692
C DT G +I C I G+C CK C+ C P G
Sbjct: 438 CPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPC-----------PPGTW 486
Query: 693 PCNCNTSGTVDGDITCHQNSGQCKCKANVIGLRCD-HCNFGFKFLRSFNDVGCEPCQCNL 751
+CN S + C +G C C G C C G F + C C+
Sbjct: 487 GFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKG-----QFGEGCASRCDCDH 541
Query: 752 HGSVNKFCNPHSGQCECKKEAKGLQCD-TCRENFYGLDVTNCKACDCDTAGSLPGTVCNA 810
C+P G+C+C+ G +C +C E +G++ +N C C G+ C
Sbjct: 542 SDG----CDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSN--TCTCKNGGT-----CLP 590
Query: 811 KTGQCICKPNVEGRQCNK-CLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCP 869
+ G C+C P G C + C G + R C+PC C C+ S G C
Sbjct: 591 ENGNCVCAPGFRGPSCQRSCQPGRYGKR------CVPCKCANHS------FCHPSNGTCY 638
Query: 870 CKLGVTGLRCNQ-CEPHRYNLTIDNFQHC-QMCECDSLGTL------------------- 908
C G TG C+Q C P + ++C Q C+C GT
Sbjct: 639 CLAGWTGPDCSQPCPPGHWG------ENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCL 692
Query: 909 -------------------PGTICDPISGQCLCVPNRQGRRCN-QCQPGFYISPGNATGC 948
PG C P +G C+C P G C Q F + P
Sbjct: 693 EGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRIGIQEPFTVMP-----T 747
Query: 949 LPCSCHTTGAV 959
P + ++ GAV
Sbjct: 748 TPVAYNSLGAV 758
Score = 73.6 bits (179), Expect = 5e-12
Identities = 68/263 (25%), Positives = 93/263 (35%), Gaps = 80/263 (30%)
Query: 814 QCICKPNVEGRQCN-KCLEGNFYLRQNNSFLCLPCNCDKTGTINGSLLCNKSTGQCPCKL 872
QC C P G C+ +C G + + + PC+C + C+ +G C C
Sbjct: 119 QCQCVPGWRGDDCSSECAPGMWGPQCDK-----PCSCGNNSS------CDPKSGVCSCPS 167
Query: 873 GVTGLRCNQ-CEPHRYNLTIDNFQHCQM-CECDSLGTLPGTICDPISGQCLCVPNRQGRR 930
G+ C Q C P Y CQ C+C G CDP +G C C R G
Sbjct: 168 GLQPPNCLQPCTPGYYG------PACQFRCQCH------GAPCDPQTGACFCPAERTGPS 215
Query: 931 C----------------NQCQ-PGFYISPGNATGCLP----------------------- 950
C + CQ G + +P + C P
Sbjct: 216 CDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQE 275
Query: 951 CSCHTTGAVNHICNSLTGQCVCQDASIAGQRC-DQCKDHYFGFDPQTGRCQPCNCHLSGA 1009
C CH G +C+ TGQC C G RC ++C FG D + C+C A
Sbjct: 276 CRCHNGG----LCDRFTGQCRCA-PGYTGDRCREECPVGRFGQD----CAETCDC----A 322
Query: 1010 LNETCHLVTGQCFCKQFVTGSKC 1032
+ C G C C+ TG +C
Sbjct: 323 PDARCFPANGACLCEHGFTGDRC 345
>gi|205360934 fibronectin type III domain containing 3B [Homo sapiens]
Length = 1204
Score = 145 bits (367), Expect = 8e-34
Identities = 218/900 (24%), Positives = 342/900 (38%), Gaps = 107/900 (11%)
Query: 3971 PWAQATSAHSVLLNWTKPES----PNGIISH---YRVVYQERPDDPTFNSPTVHAFTVKG 4023
P A +V+L+W P P+ +S Y V ++ D + G
Sbjct: 282 PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK------IIYSG 335
Query: 4024 TSHQAHLYGLEPFTTYRIGVVAANHA--GEILSPWTLIQTLESSPSGLRNFIVEQKENGR 4081
+ +L L P T Y + V A ++ G P + + + + ++
Sbjct: 336 EELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKS-- 393
Query: 4082 ALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFL-------FRRLDPFTLYTLTLEA 4134
+L LQW P+ I Y + D SG + F +L P YT L A
Sbjct: 394 SLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
Query: 4135 CTRAGCA-HSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRR 4193
G + +S +T P AP + T V L WS+P + + EVI
Sbjct: 454 RNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPE----EVITY 509
Query: 4194 CFEGKAWGNQTIQADEK--IVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCS 4251
E IQ DE + +Y E T + L+ TQ ++++ N+ G +C
Sbjct: 510 TLE--------IQEDENDNLFHPKYTGEDLTCTVKN--LKRSTQYKFRLTASNTEGKSCP 559
Query: 4252 SWNVVRTLQAPPEGLSPPVISYVS--MNPQKLLISWIPPEQSNGI-IQSYRLQRNE---- 4304
S +V T P+ PP V + + W PP+ + G I Y L+ +
Sbjct: 560 SEVLVCTTS--PDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSE 617
Query: 4305 -MLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGG---CSTSKPTSITTLEAAPSEVS 4360
+ ++ YT L P + Y ++GG CS S P + TL AP +
Sbjct: 618 ANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIAPGQCR 675
Query: 4361 PPD-LWAVSATQMNVCWSPPTVQNG-KITKYLVRYDNKESLA-----GQGLCLLVSHLQP 4413
PP L ++++ W P ++G ++++Y V E +A G L V +L P
Sbjct: 676 PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLP 735
Query: 4414 YSQYNFSLVACTNGGCTASVSKSAWTMEALPENM-DSPTLQVTGSESIEITWKPPRNPNG 4472
+ Y F + A +GG S T A P +P + T + + W+ P +
Sbjct: 736 GTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGA 795
Query: 4473 QIRSYELR-----RDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDR 4526
I Y L ++Y G +TR+ L P +Y + A N G G S LV +
Sbjct: 796 DISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQ 855
Query: 4527 TSPSAPSGM--------EPPKLQARGPQEILV-NWDPPVRTNGDIINYTLFIRELFERET 4577
T SAP + EP P LV NW+ P +I+ YT+ + + T
Sbjct: 856 TPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGD-----T 910
Query: 4578 KIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCAS-SDWTFIQTPEIAPLMQP 4636
I NTT +++ L P Y IRIQA +G S + +T + PL
Sbjct: 911 SITVGNTT-------MHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL--- 960
Query: 4637 PPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTS 4696
PP LE A G Q ++ L W N K E + + R + IY G S +
Sbjct: 961 PPRLEC--AAAGPQ-SLKLKWG---DSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT 1014
Query: 4697 FIDSELLPFTEYEYQVWAVNSAGKAPSS--WTWCRTGPAPPEGLRAPTFHVISSTQA-VV 4753
+ L FT Y +++ A + AG+ P S +T+ T PP ++AP + ++
Sbjct: 1015 YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPT-IKAPRVTQLEGNSCEIL 1073
Query: 4754 NISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNC 4813
+ P V+ + +G + GLQ T+Y V C C C
Sbjct: 1074 WETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRV--CACRRC 1131
Score = 126 bits (316), Expect = 6e-28
Identities = 213/912 (23%), Positives = 345/912 (37%), Gaps = 127/912 (13%)
Query: 3496 EDVPQGVSPPTWTKIDNLED-TIVLNWRKPIQSNG--------PIIYYILL----RNGIE 3542
+D+ G+ P ++ N++ +VL+W P+ + P Y + L R+G
Sbjct: 273 QDILSGIEKP---QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKY 329
Query: 3543 R--FRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQG-VPESILPPSIT 3599
+ + G L + K+ ++P +Y ++ A + + S+ V+ TT PE PP +
Sbjct: 330 KIIYSGEELECNLKD-LRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLA 388
Query: 3600 ALSAVALHLSWSVPEKSNGVIKEYQIR----QVGKGLIHTDTTDRRQHTVTGLQPYTNYS 3655
S +L L W P + I Y + + G ++ +T L P Y+
Sbjct: 389 HRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYT 448
Query: 3656 FTLTACTSAGCTS-SEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPE--KPNGLV 3712
F L A G + S+ + TL P+ + PR + T V L WS PE P ++
Sbjct: 449 FRLAARNDIGTSGYSQEVVCYTLGNIPQ-MPSAPRLVRAGITWVTLQWSKPEGCSPEEVI 507
Query: 3713 S---QYQLSRNGNLL---FLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQ 3766
+ + Q N NL + G E+ T KNL+ +++Y ++L G S + +V
Sbjct: 508 TYTLEIQEDENDNLFHPKYTG--EDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
Query: 3767 TPMSTPEEIYPPYNITVIGP---YSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSV 3823
T ++P+ PP V GP + V W PP ++Y + + DG+ + V
Sbjct: 566 T--TSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEV 623
Query: 3824 GHHQSTL---LENLTPFTQYEIRIQAC---QNGSCGVSSRMFVKTPEAAPMDLNSP-VLK 3876
+ S +L P T Y++R AC G S + V+T AP P VL
Sbjct: 624 AYSGSATEYTFTHLKPGTLYKLR--ACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
Query: 3877 ALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFT 3936
+ ++W P +G ++ + E E V G G+ L P T
Sbjct: 682 RPKHKEVHLEWDVPASESGCEVSEYSVEMT---EPEDVASEVYHGPELECTVGNLL-PGT 737
Query: 3937 LYEYRVRACNSKG-SVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGII 3995
+Y +RVRA N G S S T PP AP T VL+ W P+S I
Sbjct: 738 VYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADI 797
Query: 3996 SHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGE-ILS 4054
S YR+ + E D+ + GT + + L P Y + A N AG S
Sbjct: 798 SEYRLEWGE--DEESLE------LIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYS 849
Query: 4055 PWTLIQTLESSPSGLRNFIVEQKE--------NGRALLLQWSEPMRTNGVIKTYNIFSDG 4106
L QT S+P + V ++E L+L W EP I Y I
Sbjct: 850 ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGD 909
Query: 4107 FLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGC--------AHSAPQPLWTDEAPPDSQ 4158
G + + L P T Y + ++A G A + P P PP +
Sbjct: 910 TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLP----PLPPRLE 965
Query: 4159 LAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNT 4218
A + S++L W + N A E IV+T
Sbjct: 966 CA----AAGPQSLKLKWGD-----------------------SNSKTHAAEDIVYTLQLE 998
Query: 4219 ERN----------TFMYNDTGLQPWTQCEYKIYTWNSAGH-TCSSWNVVRTLQAPPEGLS 4267
+RN + Y L +T ++I + AG S T ++ P +
Sbjct: 999 DRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIK 1058
Query: 4268 PPVISYVSMNPQKLLISWIPP---EQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELL 4324
P ++ + N ++L +P + N I+Q + +E + + TF + L
Sbjct: 1059 APRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISG--LQ 1116
Query: 4325 PFSTYSYALQAC 4336
+ Y + + AC
Sbjct: 1117 TNTDYRFRVCAC 1128
Score = 123 bits (309), Expect = 4e-27
Identities = 185/797 (23%), Positives = 306/797 (38%), Gaps = 78/797 (9%)
Query: 4256 VRTLQAPPEGLSPPVISYVSMNPQKLLISWIPP-------EQSNGIIQSYRLQRNEM--- 4305
V+ +Q G+ P +S ++ + +++SW PP SY + ++
Sbjct: 269 VKRVQDILSGIEKPQVS--NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRD 326
Query: 4306 -LYPFSFDPVTFNYTDEELLPFSTYS---YALQACTSGGCSTSKPTSITTLEAAPSEVSP 4361
Y + ++L P + Y YA+ G CS +P S TT AP P
Sbjct: 327 GKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCS--EPVSFTTHSCAPECPFP 384
Query: 4362 PDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLL-------VSHLQPY 4414
P L S + + + W P KIT YL+ +D + +G C ++ L P
Sbjct: 385 PKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPA 444
Query: 4415 SQYNFSLVACTNGGCTA-SVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPR--NPN 4471
Y F L A + G + S +T+ +P+ +P L G + + W P +P
Sbjct: 445 MGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPE 504
Query: 4472 GQIR-SYELRRDGT-----IVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVK 4524
I + E++ D YTG + L +Y + +TASN++G S ++
Sbjct: 505 EVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLV 564
Query: 4525 DRTSPSAPSGMEPPKLQARGP---QEILVNWDPPVRTNG-DIINYTLFIRELFERETKII 4580
TSP P P + +GP V WDPP G +I+ Y L E+ + ++
Sbjct: 565 CTTSPDRPG--PPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLL---EITDGNSEAN 619
Query: 4581 HINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCAS-SDWTFIQTPEIAPLMQPPPH 4639
++ + Y LKP Y++R +T G + S+ ++T IAP PP
Sbjct: 620 QWEVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR 678
Query: 4640 LEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFID 4699
+ + V L W P +G E+ + + +Y+G
Sbjct: 679 VLGRPK----HKEVHLEWDVPASESG----CEVSEYSVEMTEPEDVASEVYHGPELECTV 730
Query: 4700 SELLPFTEYEYQVWAVNSAGKAP-SSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAP 4758
LLP T Y ++V A+N G P S + T PP +AP +V +P
Sbjct: 731 GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP 790
Query: 4759 GKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGP 4818
+S YRL + ++ G T+ + L Y ++A FN GP
Sbjct: 791 DSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQA---FNQAGAGP 847
Query: 4819 TAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDS-ALP 4877
+EL P S + + TL + P P+ + L + C S L
Sbjct: 848 YSELVLCQTPAS--APDPVSTLCVLEEEPLDAYPDSPSACL---VLNWEEPCNNGSEILA 902
Query: 4878 CTPSQIETKYT-GLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRA 4936
T +T T G + L P TTY++R+ A NE+G A + F K P
Sbjct: 903 YTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIG--AGPFSQFIKAKTRPLPPL 960
Query: 4937 PFSVD---SNLSVVCVNWSDTFLLNGQLKEYVLT----DGGRR---VYSGLDTTLYIPRT 4986
P ++ + + + W D+ ++ V T D +R +Y G T + R
Sbjct: 961 PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL 1020
Query: 4987 ADKT-FFFQVICTTDEG 5002
+ T + F++ ++ G
Sbjct: 1021 TEFTCYSFRIQAASEAG 1037
Score = 119 bits (298), Expect = 8e-26
Identities = 196/881 (22%), Positives = 311/881 (35%), Gaps = 145/881 (16%)
Query: 4110 YSGLNRQFLFRRLDPFTLYTLTLEAC---TRAGCAHSAPQPLWTDEAPPDSQLAPTVHSV 4166
YSG + + L P T Y + + A + C S P T P+ P +
Sbjct: 333 YSGEELECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTTHSCAPECPFPPKLAHR 390
Query: 4167 KSTSVELSWSEPVNPNGKIIRYEV----------IRRCFEGKAWGNQTIQADEKIVFTEY 4216
+S+ L W P++ KI Y + R+CF G + + + +T
Sbjct: 391 SKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFR 450
Query: 4217 NTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVR------TLQ-APPEGLSPP 4269
RN D G ++Q E YT + S+ +VR TLQ + PEG SP
Sbjct: 451 LAARN-----DIGTSGYSQ-EVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPE 504
Query: 4270 VISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTY 4329
+ ++ Q+ N+ L+ + T + L + Y
Sbjct: 505 EVITYTLEIQE--------------------DENDNLFHPKYTGEDLTCTVKNLKRSTQY 544
Query: 4330 SYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDL----WAVSATQMNVCWSPPTVQNG- 4384
+ L A + G S P+ + +P PP V++ +V W PP G
Sbjct: 545 KFRLTASNTEGKSC--PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGS 602
Query: 4385 KITKYLVRYDNKESLA--------GQGLCLLVSHLQPYSQYNFSLVACTNGGCT-ASVSK 4435
+I KYL+ + S A G +HL+P + Y + GG + S S
Sbjct: 603 EILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESL 662
Query: 4436 SAWTMEALPENMDSP-TLQVTGSESIEITWKPPRNPNG-QIRSYELRRD-----GTIVYT 4488
T+ P P L + + + W P + +G ++ Y + + VY
Sbjct: 663 PVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYH 722
Query: 4489 GLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDRTSPSAPSGMEPPKLQARGPQE 4547
G E L PG Y + V A N G G S + + T+ P + P +
Sbjct: 723 GPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGC 782
Query: 4548 ILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEI 4607
+LV W+ P + DI Y L E E I H T + + L P +Y
Sbjct: 783 VLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTR-------FEIRDLLPAAQYCC 835
Query: 4608 RIQACTTLGCAS-SDWTFIQTPEIAP-------LMQPPPHLEVQMAPGGFQPTVSLLWTG 4659
R+QA G S+ QTP AP +++ P + P + L W
Sbjct: 836 RLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEP---LDAYPDSPSACLVLNWEE 892
Query: 4660 PLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAG 4719
P ++L Y + I G++T + +LLP T Y ++ A+N G
Sbjct: 893 PCNNGSEILAYTI----------DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIG 942
Query: 4720 KAP-SSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGA 4778
P S + +T P PP R + +A G P + + +S H A
Sbjct: 943 AGPFSQFIKAKTRPLPPLPPR-------------LECAAAG-PQSLKLKWGDSNSKTHAA 988
Query: 4779 ETV---------------LSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAE-- 4821
E + + G + + L FT YS ++A + +GP +E
Sbjct: 989 EDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASE---AGEGPFSETY 1045
Query: 4822 -LRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTP 4880
T + P + +P++ L + W G +Y LQ V
Sbjct: 1046 TFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVG---------RE 1096
Query: 4881 SQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASE 4921
S+ + Y G + GLQ T Y+ RV A T+ E
Sbjct: 1097 SEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQE 1137
Score = 116 bits (291), Expect = 5e-25
Identities = 187/780 (23%), Positives = 303/780 (38%), Gaps = 75/780 (9%)
Query: 2019 LTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPP-VAKSLPSSLLLSWNP 2077
L L P +Y V + A + S ++ +T AP+ PP +A SSL L W
Sbjct: 342 LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
Query: 2078 PKKANGIITQYCLYMDG-------RLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTN 2130
P IT Y L D R + GS+++ +T L + F L+A +G +
Sbjct: 402 PIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSG 461
Query: 2131 -SSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGI-LERYVLYMSNHTHDFT 2188
S V+ YT P+ +P L + +QW +P S + Y L + +D
Sbjct: 462 YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDEND-N 520
Query: 2189 IWSVIYNSTELFQDHMLQYVLPGNKYLIKLGAC-TGGGCTVSEASEALTDEDIPEGVPAP 2247
++ Y +L ++ + +Y +L A T G SE T D P P
Sbjct: 521 LFHPKYTGEDL--TCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRP 578
Query: 2248 KAHS-YSPDSFNVSWTEPEYPNGV-ITSYGLYL-DGILIHNSSELSYRA----YGFA--- 2297
+ F+V W P+ G I Y L + DG N E++Y Y F
Sbjct: 579 LVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLK 638
Query: 2298 PWSLHSFRVQACTAKGCA-LGPLVENRTLE-APPEGTVNVFVKTQGSRKAHVRWEAPFRP 2355
P +L+ R + G + + RTL AP + + ++ H+ W+ P
Sbjct: 639 PGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE 698
Query: 2356 NGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNIS 2415
+G V + +P +V +Y G E L + L+P T Y +V
Sbjct: 699 SGC---EVSEYSVEMTEPE-------DVASEVYHGPE--LECTVGNLLPGTVYRFRVRAL 746
Query: 2416 NSQG----SLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQL 2471
N G S +++ T A PPG P +S + V W +P + A S Y+L
Sbjct: 747 NDGGYGPYSDVSEITTAAGPPGQCKA---PCISCTPDGCVLVGWESPDSSGADIS-EYRL 802
Query: 2472 QMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSA-HSSWIPFMTAE 2530
+ + + LEL + +E+ DL P +Y RL A N G+ +S + T
Sbjct: 803 EWGEDEES---LELIYH-GTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPA 858
Query: 2531 DKPGPVVPPILL---------DVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGN 2581
P PV +L D S +++ W+ P + I Y I L T GN
Sbjct: 859 SAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSI--TVGN 916
Query: 2582 VTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWT----LPGAPEGIPSPELFSDTP 2637
T + L P T Y+ +++A G P SQ + LP P P E + P
Sbjct: 917 TTMHVMKDLLPETTYRIRIQAINEIGAG--PFSQFIKAKTRPLPPLP---PRLECAAAGP 971
Query: 2638 TSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYE 2697
S+ + W E+ +++ + + + SH+ K L+ +T Y
Sbjct: 972 QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTY----KVQRLTEFTCYS 1027
Query: 2698 YRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSY 2757
+R+ ++ G S +T S P ++ P VT LE ++ ++ W+ GD ++Y
Sbjct: 1028 FRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNY 1087
Score = 109 bits (273), Expect = 6e-23
Identities = 194/856 (22%), Positives = 324/856 (37%), Gaps = 84/856 (9%)
Query: 2146 VDSPVLTVLDSRTIHIQWKQPRKIS-------GILERYVLYMSNHTHDFTIWSVIYNSTE 2198
++ P ++ + +R + + W P +S Y + +S+ D + +IY+ E
Sbjct: 279 IEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGK-YKIIYSGEE 337
Query: 2199 LFQDHMLQYVLPGNKYLIKLGACTG---GGCTVSEASEALTDEDIPEGVPAPKAHSYSPD 2255
L + L+ + P Y +++ A G C SE T PE PK S
Sbjct: 338 L--ECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTTHSCAPECPFPPKLAHRSKS 393
Query: 2256 SFNVSWTEPEYPNGVITSYGLYLDGILIHNS-------SELSYRAYGFAPWSLHSFRVQA 2308
S + W P IT+Y L D ++ S+ + P ++FR+ A
Sbjct: 394 SLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
Query: 2309 CTAKGCA-LGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTG 2367
G + V TL P+ + G ++W +P G V+ T
Sbjct: 454 RNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWS---KPEGCSPEEVI-TY 509
Query: 2368 IFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPIT 2427
+ N+ N+ Y+GE+ L + L T Y ++ SN++G + P
Sbjct: 510 TLEIQEDEND----NLFHPKYTGED--LTCTVKNLKRSTQYKFRLTASNTEGK--SCPSE 561
Query: 2428 IAMPPGAPDGVLPPRL----SSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFL 2483
+ + +PD PP T V W P N +Y L++ G+S
Sbjct: 562 VLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
Query: 2484 ELFSNPSASLSYEVSDLQPYTEYMFRLVA-SNGFGSAHSSWIPFMTAEDKPGPVVPPILL 2542
E+ + SA+ Y + L+P T Y R S G S S +P T PG PP +L
Sbjct: 622 EVAYSGSAT-EYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVL 680
Query: 2543 D-VKSRMMLVTWQHPRKSNGV-ITHYNIYLHGRLYLRTP---GNVTNCTVMHLHPYTAYK 2597
K + + + W P +G ++ Y++ + + + G CTV +L P T Y+
Sbjct: 681 GRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYR 740
Query: 2598 FQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENF 2657
F+V A G + + T G P +P + V++ W+ P +
Sbjct: 741 FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS-- 798
Query: 2658 TIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEV 2717
E R++ E+ +L + RF + L P +Y R+ G S V
Sbjct: 799 --EYRLEWGEDEESLELIYHGTDTRF--EIRDLLPAAQYCCRLQAFNQAGAGPYSELVLC 854
Query: 2718 TTRPSRPAGVQPPVVTVLEP-DA--------VQVTWKPPLIQNGDILSYEIHMPDPHITL 2768
T S P V V EP DA + + W+ P +IL+Y I + D IT+
Sbjct: 855 QTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITV 914
Query: 2769 TNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLS 2828
N T V+ L+P T Y + I A + G ++ + P +P + +
Sbjct: 915 GNTTMHVMKD----LLPETTYRIRIQAINEIGA--GPFSQFIKAKTRPLPPLPPRLECAA 968
Query: 2829 VIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLN-RWHNIYSGTQWLY 2887
P S + + W N E + +Q ED N R+ +IY G Y
Sbjct: 969 AGPQS---LKLKW---GDSNSKTHAAEDIVYTLQL-------EDRNKRFISIYRGPSHTY 1015
Query: 2888 EDKGLSRFTTYEYMLFVHNSVGFTP-SREVTVTTLAGLPERGANLTASVLNHTAIDVRWA 2946
+ + L+ FT Y + + + G P S T +T +P + L + ++ W
Sbjct: 1016 KVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILW- 1074
Query: 2947 KPTVQDLQGEVEYYTL 2962
TV ++G+ Y L
Sbjct: 1075 -ETVPSMKGDPVNYIL 1089
Score = 92.0 bits (227), Expect = 1e-17
Identities = 191/858 (22%), Positives = 320/858 (37%), Gaps = 97/858 (11%)
Query: 1893 STDSAVNCRGNDSI--LVYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTT 1950
S + A++ +G D ++Y G+E L+P T+Y RV A + TT
Sbjct: 315 SYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTT 374
Query: 1951 GAAPQSVPTPSRVRSLNGYSIEVTWDEPVVRG-VIEKYILKAYSEDSTRPPRMPSASAEF 2009
+ P P ++ + S+ + W P+ G I Y+L+ + E + S +
Sbjct: 375 HSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLE-WDEG-----KRNSGFRQC 428
Query: 2010 VNTSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPP-VAKSLP 2068
S LT L P Y L A G + S + T PQ P + ++
Sbjct: 429 FFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGI 488
Query: 2069 SSLLLSWNPPK--KANGIITQYCLYM----DGRLI---YSGSEENYTVTDLAVFTPHQFL 2119
+ + L W+ P+ +IT Y L + + L Y+G + TV +L T ++F
Sbjct: 489 TWVTLQWSKPEGCSPEEVIT-YTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFR 547
Query: 2120 LSACTHVGCTNSSWVLLYTAQLPPEHVDSP----VLTVLDSRTIHIQWKQPRKISGI-LE 2174
L+A G + S VL+ T P+ P V + S ++W P+ G +
Sbjct: 548 LTASNTEGKSCPSEVLVCTTS--PDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEIL 605
Query: 2175 RYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGAC---TGGGCTVSEA 2231
+Y+L +++ + W V Y+ + ++ ++ PG Y KL AC TGG SE+
Sbjct: 606 KYLLEITDGNSEANQWEVAYSGSA--TEYTFTHLKPGTLY--KLRACCISTGGHSQCSES 661
Query: 2232 SEALTDEDIPEGVPAPKAHSY-SPDSFNVSWTEPEYPNGV-ITSYGLYLD-----GILIH 2284
T P P+ ++ W P +G ++ Y + + ++
Sbjct: 662 LPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVY 721
Query: 2285 NSSELSYRAYGFAPWSLHSFRVQACTAKGCALGP---LVENRTLEAPPEGTVNVFVKTQG 2341
+ EL P +++ FRV+A G GP + E T PP +
Sbjct: 722 HGPELECTVGNLLPGTVYRFRVRALNDGG--YGPYSDVSEITTAAGPPGQCKAPCISCTP 779
Query: 2342 SRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDG 2401
V WE+P ++ L G + +L +++Y G +T I
Sbjct: 780 DGCVLVGWESPDSSGADISEYRLEWG-------EDEESL----ELIYHGTDTRF--EIRD 826
Query: 2402 LVPFTNYTVQVNISNSQGS-LITDPITIAMPPGAPDG-----VLPPRLSSATPTS----L 2451
L+P Y ++ N G+ ++ + P APD VL A P S L
Sbjct: 827 LLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACL 886
Query: 2452 QVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLV 2511
+ W P N GS + GD++ + + + DL P T Y R+
Sbjct: 887 VLNWEEPCNN---GSEILAYTIDLGDTS-------ITVGNTTMHVMKDLLPETTYRIRIQ 936
Query: 2512 ASNGFGSAHSSWIPFMTAEDKPGPVVPPIL--LDVKSRMMLVTWQHPRKSNGVITH--YN 2567
A N G+ S F+ A+ +P P +PP L + + + W Y
Sbjct: 937 AINEIGAGPFS--QFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYT 994
Query: 2568 IYLHGR-----LYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPG 2622
+ L R R P + V L +T Y F+++A + G E+ T T
Sbjct: 995 LQLEDRNKRFISIYRGPSHTYK--VQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKS 1052
Query: 2623 APEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMR 2682
P I +P + S I W+ G N+ ++ V + E + +
Sbjct: 1053 VPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY---KGEEAT 1109
Query: 2683 FIDKTSALSPWTKYEYRV 2700
F + S L T Y +RV
Sbjct: 1110 F--QISGLQTNTDYRFRV 1125
Score = 89.0 bits (219), Expect = 1e-16
Identities = 137/613 (22%), Positives = 230/613 (37%), Gaps = 54/613 (8%)
Query: 3465 NLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDN--LEDTIVLNWR 3522
NLK Y++R++A N+ G+ V T P PPT + + W
Sbjct: 537 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTS--PDRPGPPTRPLVKGPVTSHGFSVKWD 594
Query: 3523 KPIQSNGPII--YYILLRNGIERFRGTSLSFSDKEGIQPFQEYS----YQLKACTVA--G 3574
P + G I Y + + +G +++S F Y+L+AC ++ G
Sbjct: 595 PPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGG 654
Query: 3575 CATSSKVVAATTQGV-PESILPPSITAL-SAVALHLSWSVPEKSNGV-IKEYQIRQVGKG 3631
+ S+ + T + P PP + +HL W VP +G + EY +
Sbjct: 655 HSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPE 714
Query: 3632 LIHTDT--TDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPR 3689
+ ++ + TV L P T Y F + A G T A P G P
Sbjct: 715 DVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPC 774
Query: 3690 HIIINSTTVELYWSLPEKPNGLVSQYQL---SRNGNLLFLGGSEEQNFTDKNLEPNSRYT 3746
V + W P+ +S+Y+L +L + + F ++L P ++Y
Sbjct: 775 ISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYC 834
Query: 3747 YKLEV-KTGGGSSASDDYIVQTPMSTPEEI-------YPPYNITVIGPYSIFVA-WIPPG 3797
+L+ G S+ + QTP S P+ + P + P + V W P
Sbjct: 835 CRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC 894
Query: 3798 ILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSR 3857
EI + Y + L D S+T VG+ ++++L P T Y IRIQA G S+
Sbjct: 895 NNGSEI-LAYTIDLGDTSIT-----VGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 948
Query: 3858 MFVKTPEAAPMDLNSPVLK--ALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVL 3915
F+K + P+ P L+ A G +++KW + +Y +E+ +
Sbjct: 949 -FIKA-KTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAED-IVY--TLQLEDRNKR 1003
Query: 3916 FVWSEGALEFMDEGDTLRPFTLYEYRVRACN--SKGSVESLWSLTQTLEAPPQDFPAPWA 3973
F+ + L FT Y +R++A + +G ++ + T PP AP
Sbjct: 1004 FISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPP-TIKAPRV 1062
Query: 3974 QATSAHSVLLNW-TKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYG 4032
+S + W T P +++ V R + + KG + G
Sbjct: 1063 TQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESE--------YKQVYKGEEATFQISG 1114
Query: 4033 LEPFTTYRIGVVA 4045
L+ T YR V A
Sbjct: 1115 LQTNTDYRFRVCA 1127
Score = 82.0 bits (201), Expect = 1e-14
Identities = 134/633 (21%), Positives = 247/633 (39%), Gaps = 60/633 (9%)
Query: 1909 YQGKEQSVYEGGLQPFTEYLYRVIASH-EGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLN 1967
Y G++ + L+ T+Y +R+ AS+ EG S S+ T+ P P +
Sbjct: 526 YTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVT 585
Query: 1968 GYSIEVTWDEPVVRGVIE--KYILK---AYSEDSTRPPRMPSASAEFVNTSNLTGILTGL 2022
+ V WD P G E KY+L+ SE + ++ E+ T L
Sbjct: 586 SHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYT--------FTHL 637
Query: 2023 LPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKSLPS--SLLLSWNPPKK 2080
P Y + + G ++ S +L + T AP + +PP P + L W+ P
Sbjct: 638 KPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPAS 697
Query: 2081 ANGI-ITQYCLYMD-----GRLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWV 2134
+G +++Y + M +Y G E TV +L T ++F + A G S V
Sbjct: 698 ESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDV 757
Query: 2135 L-LYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIWSVI 2193
+ TA PP +P ++ + + W+ P + Y L + I
Sbjct: 758 SEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLEL---I 814
Query: 2194 YNSTELFQDHMLQYVLPGNKYLIKLGACTGGGC----------TVSEASEALTDEDIPEG 2243
Y+ T+ + ++ +LP +Y +L A G T + A + ++ + E
Sbjct: 815 YHGTDTRFE--IRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEE 872
Query: 2244 VPAPKAHSYSPDSFNV-SWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLH 2302
P A+ SP + V +W EP I +Y + L I + + P + +
Sbjct: 873 EPLD-AYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTY 931
Query: 2303 SFRVQACTAKGCA-LGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTH 2361
R+QA G ++ +T PP + G + ++W + TH
Sbjct: 932 RIRIQAINEIGAGPFSQFIKAKTRPLPPLPP-RLECAAAGPQSLKLKWG----DSNSKTH 986
Query: 2362 SVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGS- 2420
+ ++ + N +++ Y G V L FT Y+ ++ ++ G
Sbjct: 987 AAEDI-VYTLQLEDRNKRFISI----YRGPSHTYKV--QRLTEFTCYSFRIQAASEAGEG 1039
Query: 2421 LITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWST-PARNNAPGSPRYQLQMRSGDST 2479
++ T + P + PR++ S +++W T P+ P + Y LQ+ G +
Sbjct: 1040 PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVN--YILQVLVGRES 1097
Query: 2480 HGFLELFSNPSASLSYEVSDLQPYTEYMFRLVA 2512
+ +++ A+ +++S LQ T+Y FR+ A
Sbjct: 1098 E-YKQVYKGEEAT--FQISGLQTNTDYRFRVCA 1127
Score = 78.2 bits (191), Expect = 2e-13
Identities = 130/549 (23%), Positives = 202/549 (36%), Gaps = 49/549 (8%)
Query: 2626 GIPSPELFSDTPTSVIISWQPPTH-----PNGLVENFTIERRV--KGKEEVTTLVTLPRS 2678
GI P++ + +V++SW PP +GL ++ E + KG++ ++
Sbjct: 278 GIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEE 337
Query: 2679 HSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPD 2738
D L P T Y RV + S V TT P PP +
Sbjct: 338 LECNLKD----LRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKS 393
Query: 2739 AVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQK---VTHLIPFTNYSVTIVA 2795
++ + WK P+ I +Y + + SQK +T L P Y+ + A
Sbjct: 394 SLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
Query: 2796 CS--GGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPNLR 2853
+ G +GY S T +PQ ++ ++V + W SKP G +
Sbjct: 454 RNDIGTSGY------SQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQW---SKPEGCSPE 504
Query: 2854 YELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPS 2913
I L E+ N +H Y+G K L R T Y++ L N+ G +
Sbjct: 505 -----EVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
Query: 2914 REVTVTTLA----GLPERGANLTASVLNHTAIDVRWAKPTVQDLQG-EVEYYTLFWSSAT 2968
EV V T + G P R + V +H V+W P +D G E+ Y L +
Sbjct: 560 SEVLVCTTSPDRPGPPTRPL-VKGPVTSH-GFSVKWDPP--KDNGGSEILKYLLEITDGN 615
Query: 2969 SNDS---LKILPDVNSHVIGHLKPNTEYWI-FISVFNGVHSINSAGLHATTCDGEPQGML 3024
S + + + HLKP T Y + + G HS S L T P
Sbjct: 616 SEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCR 675
Query: 3025 PPEVV-IINSTAVRVIWTSPSNPNGV-VTEYSIYVNNKLYKTGMNVPGSFI---LRDLSP 3079
PP V+ V + W P++ +G V+EYS+ + G + + +L P
Sbjct: 676 PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLP 735
Query: 3080 FTIYDIQVEVCTIYACVK-SNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNG 3138
T+Y +V S+ ++ITT P P I + + W SP
Sbjct: 736 GTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGA 795
Query: 3139 IILGYDLLW 3147
I Y L W
Sbjct: 796 DISEYRLEW 804
Score = 67.8 bits (164), Expect = 3e-10
Identities = 110/460 (23%), Positives = 164/460 (35%), Gaps = 55/460 (11%)
Query: 1059 PPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLD-TDLLP 1117
PP+ +S S++ L W P + Y L D + + Q + Q T L P
Sbjct: 384 PPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
Query: 1118 YTKYSYYIETTNVHG----STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLS 1173
Y++ + N G S V T P +P ++ G VTL W+
Sbjct: 444 AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA----PRLVRAGITWVTLQWSKPE 499
Query: 1174 NQSGP-IEKYILSCAPLAGGQPC-VSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHS 1231
S + Y L Y G + + T+ NL +Y F + A + G S
Sbjct: 500 GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG--KS 557
Query: 1232 LPITVTTAQAPPQRLSPPKMQ----KISSTELHVEWSPPAELNGI-IIRYELYMRRLRST 1286
P V P R PP ++S V+W PP + G I++Y L
Sbjct: 558 CPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLL-------- 609
Query: 1287 KETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG 1346
E T S Q W E A T T T L+P T Y+ R ++ G
Sbjct: 610 -EITDGNSEANQ---W-----------EVAYSGSATEYTFTHLKPGTLYKLRACCISTGG 654
Query: 1347 -SVSSAWVSERTGESAPVFMIPPSVFPLSSYS-LNISWEKPADNVTRGKVVGYDINMLSE 1404
S S + RT AP PP V + +++ W+ PA + +V Y + M
Sbjct: 655 HSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE-SGCEVSEYSVEMTEP 713
Query: 1405 QSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLA 1464
+ S++ H EL TV L P +Y F + N G + + T A
Sbjct: 714 ED-------VASEVYH---GPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA 763
Query: 1465 AA-PAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLE 1503
A P Q + P + + + W P+ Y+LE
Sbjct: 764 AGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLE 803
Score = 64.3 bits (155), Expect = 3e-09
Identities = 135/652 (20%), Positives = 230/652 (35%), Gaps = 73/652 (11%)
Query: 2539 PILLDVKSRMMLVTWQHP-----RKSNGVITHYNIYL-------HGRLYLRTPGNVTNCT 2586
P + ++++R ++++W P +G+ Y+ + G+ + G C
Sbjct: 282 PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
Query: 2587 VMHLHPYTAYKFQVEACTS--KGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISW 2644
+ L P T Y +V A + KG P S T + APE P+L + +S+ + W
Sbjct: 342 LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSC--APECPFPPKLAHRSKSSLTLQW 399
Query: 2645 QPPTHPNGLVENFTIE-RRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMS 2703
+ P + N+ +E K + H K + L P Y +R+
Sbjct: 400 KAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHC-----KLTKLCPAMGYTFRLAAR 454
Query: 2704 TLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTW-KPPLIQNGDILSYEIHMP 2762
G + S V T + P P + V + W KP ++++Y + +
Sbjct: 455 NDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQ 514
Query: 2763 D---PHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPT 2819
+ ++ T L+ V +L T Y + A S G +S P+ V T
Sbjct: 515 EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA-SNTEG------KSCPSEVLVCTT 567
Query: 2820 VPQNVG----PLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNR 2875
P G PL P++ + W PP G + LL ++ + N+
Sbjct: 568 SPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE-------ITDGNSEANQ 620
Query: 2876 WHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTP-SREVTVTTLAGLPERGANLTAS 2934
W YSG+ Y L T Y+ ++ G + S + V TL+ P G
Sbjct: 621 WEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAP--GQCRPPR 678
Query: 2935 VL---NHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNT 2991
VL H + + W P + EY + P++ +G+L P T
Sbjct: 679 VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELEC-TVGNLLPGT 737
Query: 2992 EYWIFISVFN-GVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVV 3050
Y + N G + S TT G P P + V V W SP + +
Sbjct: 738 VYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADI 797
Query: 3051 TEYSIYVNNKLYKTGMNVPGS---FILRDLSPFTIYDIQVE--------------VCTIY 3093
+EY + + G+ F +RDL P Y +++ +C
Sbjct: 798 SEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTP 857
Query: 3094 ACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDL 3145
A + + +E+ P D + S L ++W P IL Y +
Sbjct: 858 ASAPDPVSTLCVLEEEPLDAYPDS----PSACLVLNWEEPCNNGSEILAYTI 905
Score = 64.3 bits (155), Expect = 3e-09
Identities = 99/445 (22%), Positives = 165/445 (37%), Gaps = 41/445 (9%)
Query: 1890 GCLSTDSAVNCRGNDSIL--VYQGKEQSVYEGGLQPFTEYLYRVIASHEGG-SVYSDWSR 1946
GC ++ +V + + VY G E G L P T Y +RV A ++GG YSD S
Sbjct: 700 GCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
Query: 1947 GRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVVRGV-IEKYILKAYSEDSTRPPRMPSA 2005
T P P + +G + V W+ P G I +Y L+ + ED
Sbjct: 760 ITTAAGPPGQCKAPCISCTPDG-CVLVGWESPDSSGADISEYRLE-WGED--------EE 809
Query: 2006 SAEFVNTSNLTGI-LTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEV----- 2059
S E + T + LLP Y L A AG S + TP AP V
Sbjct: 810 SLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCV 869
Query: 2060 --QPPV---AKSLPSSLLLSWNPPKKANGIITQYCLYMDGRLIYSGSEENYTVTDLAVFT 2114
+ P+ S + L+L+W P I Y + + I G+ + + DL T
Sbjct: 870 LEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPET 929
Query: 2115 PHQFLLSACTHVGC-TNSSWVLLYTAQLPPEHVDSPVL--TVLDSRTIHIQWKQPRKISG 2171
++ + A +G S ++ T LPP P L +++ ++W +
Sbjct: 930 TYRIRIQAINEIGAGPFSQFIKAKTRPLPPL---PPRLECAAAGPQSLKLKWGDSNSKTH 986
Query: 2172 ILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACT-GGGCTVSE 2230
E V + + S+ + ++ +Q + Y ++ A + G SE
Sbjct: 987 AAEDIVYTLQLEDRNKRFISIYRGPSHTYK---VQRLTEFTCYSFRIQAASEAGEGPFSE 1043
Query: 2231 ASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSY------GLYLDGILIH 2284
T + +P + AP+ +S + W G +Y G + ++
Sbjct: 1044 TYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY 1103
Query: 2285 NSSELSYRAYGFAPWSLHSFRVQAC 2309
E +++ G + + FRV AC
Sbjct: 1104 KGEEATFQISGLQTNTDYRFRVCAC 1128
Score = 64.3 bits (155), Expect = 3e-09
Identities = 69/258 (26%), Positives = 109/258 (42%), Gaps = 39/258 (15%)
Query: 3441 EEMCSSAEE----TIHTGSV-----NTYSYTDVNLKPYMTYEYRISAWNSYGRG-LSKAV 3490
EE C++ E TI G NT + +L P TY RI A N G G S+ +
Sbjct: 891 EEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFI 950
Query: 3491 RARTKEDVPQGVSPPTWTKIDNLEDTIVLNW---RKPIQSNGPIIYYILLRNGIERF--- 3544
+A+T+ P PP ++ L W + I+Y + L + +RF
Sbjct: 951 KAKTR---PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISI 1007
Query: 3545 -RGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVA-ATTQGVPESILPPSITALS 3602
RG S ++ + + F YS++++A + AG S+ +TT+ VP +I P +T L
Sbjct: 1008 YRGPSHTYKVQR-LTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE 1066
Query: 3603 AVALHLSWSVPEKSNG----------VIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYT 3652
+ + W G V +E + +QV KG + ++GLQ T
Sbjct: 1067 GNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKG-------EEATFQISGLQTNT 1119
Query: 3653 NYSFTLTACTSAGCTSSE 3670
+Y F + AC TS E
Sbjct: 1120 DYRFRVCACRRCLDTSQE 1137
Score = 60.8 bits (146), Expect = 3e-08
Identities = 83/325 (25%), Positives = 126/325 (38%), Gaps = 54/325 (16%)
Query: 1192 GQPCVSYEGHETSATIWNLVPFAKYDFSVQAC---TSGGCLHSLPITVTTAQAPPQRLSP 1248
G+ + Y G E + +L P Y V A G C S P++ TT P+ P
Sbjct: 327 GKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTTHSCAPECPFP 384
Query: 1249 PKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSF 1308
PK+ S + L ++W P + I Y L E ++SG+
Sbjct: 385 PKLAHRSKSSLTLQWKAPIDNGSKITNYLL-------------EWDEGKRNSGF------ 425
Query: 1309 VESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERTGESAPVFMIP 1367
Q +T L P Y FR+ A N G S S V T + P
Sbjct: 426 -----RQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA 480
Query: 1368 PSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTA-KSQE 1426
P + + + W KP + + +V+ Y + + +++ L H ++
Sbjct: 481 PRLVRAGITWVTLQWSKP-EGCSPEEVITYTLEIQEDEN---------DNLFHPKYTGED 530
Query: 1427 LSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRP-----PLVKG-INS 1480
L+ TV+ LK Y+F +T N+ G S + L + RP PLVKG + S
Sbjct: 531 LTCTVKNLKRSTQYKFRLTASNTEG----KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTS 586
Query: 1481 TTIHLKWFPPEELNGPSPI--YQLE 1503
+KW PP++ NG S I Y LE
Sbjct: 587 HGFSVKWDPPKD-NGGSEILKYLLE 610
Score = 55.5 bits (132), Expect = 1e-06
Identities = 99/445 (22%), Positives = 175/445 (39%), Gaps = 52/445 (11%)
Query: 2725 AGVQPPVVTVLEPDAVQVTWKPPL-IQNGD------ILSYEIHMPDPHIT---LTNVTSA 2774
+G++ P V+ ++ AV ++W PP+ + G SYE+ + D +
Sbjct: 277 SGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGE 336
Query: 2775 VLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSE 2834
L + L P T+Y V + A N G C+E P TTH P+ P + S+
Sbjct: 337 ELECNLKDLRPATDYHVRVYAMY--NSVKGSCSE--PVSFTTHSCAPECPFPPKLAHRSK 392
Query: 2835 SYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSR 2894
S + + W+ P NG + LL + + + + + G+Q + L
Sbjct: 393 SSLTLQWKAPI-DNGSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
Query: 2895 FTTYEYMLFVHNSVGFTP-SREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDL 2953
Y + L N +G + S+EV TL +P+ + T + ++W+KP
Sbjct: 444 AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSP 503
Query: 2954 QGEVEYYTLFWSSATSNDSL---KILPDVNSHVIGHLKPNTEYWIFISVFNGV-HSINSA 3009
+ EV YTL ND+L K + + + +LK +T+Y ++ N S S
Sbjct: 504 E-EVITYTL-EIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 561
Query: 3010 GLHATTCDGEPQGMLPPEVV-IINSTAVRVIWTSPSNPNG-VVTEYSIYV---NNKLYKT 3064
L TT P P V + S V W P + G + +Y + + N++ +
Sbjct: 562 VLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
Query: 3065 GMNVPGS---FILRDLSPFTIYDIQVEVCTIYACVKSNG-------TQITTVEDTPSDIP 3114
+ GS + L P T+Y ++ C+ + G + T+ P
Sbjct: 622 EVAYSGSATEYTFTHLKPGTLYKLRA------CCISTGGHSQCSESLPVRTLSIAPGQCR 675
Query: 3115 TPTIRGITS-RSLQIDWVSPRKPNG 3138
P + G + + ++W P +G
Sbjct: 676 PPRVLGRPKHKEVHLEWDVPASESG 700
Score = 52.8 bits (125), Expect = 9e-06
Identities = 92/419 (21%), Positives = 146/419 (34%), Gaps = 56/419 (13%)
Query: 3465 NLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDT----IVLN 3520
NL P Y +R+ A N G G V ++ PP K + T +++
Sbjct: 732 NLLPGTVYRFRVRALNDGGYGPYSDV-----SEITTAAGPPGQCKAPCISCTPDGCVLVG 786
Query: 3521 WRKPIQSNGPIIYYILLRNGIER-----FRGTSLSFSDKEGIQPFQEYSYQLKACTVAGC 3575
W P S I Y L E + GT F ++ + P +Y +L+A AG
Sbjct: 787 WESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRD-LLPAAQYCCRLQAFNQAGA 845
Query: 3576 ATSSKVVAATTQGVPESILPPSITAL-------------SAVALHLSWSVPEKSNGVIKE 3622
S++V T P S P T + L L+W P + I
Sbjct: 846 GPYSELVLCQT---PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILA 902
Query: 3623 YQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPE 3682
Y I + +TT H + L P T Y + A G F+ + P
Sbjct: 903 YTIDLGDTSITVGNTT---MHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPP 959
Query: 3683 GVWVTPR--HIIINSTTVELYW----SLPEKPNGLVSQYQL-SRNGNLLFLGGSEEQNFT 3735
+ PR +++L W S +V QL RN + + +
Sbjct: 960 ---LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYK 1016
Query: 3736 DKNLEPNSRYTYKLEVKTGGGSSA-SDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWI 3794
+ L + Y+++++ + G S+ Y T S P I P +T + S + W
Sbjct: 1017 VQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAP-RVTQLEGNSCEILW- 1074
Query: 3795 PPGILIPEI---PVEY--NVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQ 3848
+P + PV Y VL+ S + G + + L T Y R+ AC+
Sbjct: 1075 ---ETVPSMKGDPVNYILQVLVGRESEYKQVYK-GEEATFQISGLQTNTDYRFRVCACR 1129
Score = 49.7 bits (117), Expect = 8e-05
Identities = 93/378 (24%), Positives = 144/378 (38%), Gaps = 51/378 (13%)
Query: 1045 NNLLGCSKTPFQQPPP-----RGQVQSSSAINLSWSPP-DSPNAHWLTYSL-LRDG-FEI 1096
+ +L C+ +P + PP +G V +S ++ W PP D+ + L Y L + DG E
Sbjct: 560 SEVLVCTTSPDRPGPPTRPLVKGPV-TSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 618
Query: 1097 YTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTR-SVAVTYKTKPGVPEGNLTLS 1155
E Y S + T L P T Y + G ++ S ++ +T P
Sbjct: 619 NQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR 678
Query: 1156 YIIPIGSDSVTLTWTTLSNQSG-PIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFA 1214
+ V L W +++SG + +Y + V Y G E T+ NL+P
Sbjct: 679 VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV-YHGPELECTVGNLLPGT 737
Query: 1215 KYDFSVQACTSGGC-LHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGII 1273
Y F V+A GG +S +TTA PP + P + + V W P I
Sbjct: 738 VYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADI 797
Query: 1274 IRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYT 1333
Y L E +E + E T I L P
Sbjct: 798 SEYRL---------EWGEDEESL-----------------ELIYHGTDTRFEIRDLLPAA 831
Query: 1334 KYEFRVLAVNMAGS-VSSAWVSERTGESAPVFMIPPSVF---PLSSY------SLNISWE 1383
+Y R+ A N AG+ S V +T SAP + V PL +Y L ++WE
Sbjct: 832 QYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWE 891
Query: 1384 KPADNVTRGKVVGYDINM 1401
+P +N +++ Y I++
Sbjct: 892 EPCNN--GSEILAYTIDL 907
Score = 49.3 bits (116), Expect = 1e-04
Identities = 99/454 (21%), Positives = 161/454 (35%), Gaps = 69/454 (15%)
Query: 1043 DVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQ 1102
DV+ + + P Q P + + W PDS A Y L G + + E
Sbjct: 756 DVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRL-EWGEDEESLELI 814
Query: 1103 YPYSIQYFLDTDLLPYTKYSYYIETTNVHGS-TRSVAVTYKTKPGVPEGNLTLSYIIPIG 1161
Y + F DLLP +Y ++ N G+ S V +T P+ TL +
Sbjct: 815 YHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEP 874
Query: 1162 SDS--------VTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPF 1213
D+ + L W N I Y + G ++ G+ T + +L+P
Sbjct: 875 LDAYPDSPSACLVLNWEEPCNNGSEILAYTIDL-----GDTSITV-GNTTMHVMKDLLPE 928
Query: 1214 AKYDFSVQACTS-GGCLHSLPITVTTAQAPPQRLSPPKMQKISS--TELHVEWSPPAELN 1270
Y +QA G S I T PP PP+++ ++ L ++W
Sbjct: 929 TTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL---PPRLECAAAGPQSLKLKWGD----- 980
Query: 1271 GIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENAL---KPPQTMTTIT 1327
S +T + E V+ +E N+ + + P +
Sbjct: 981 --------------SNSKTHAAEDIVYTLQ--------LEDRNKRFISIYRGPSHTYKVQ 1018
Query: 1328 GLEPYTKYEFRVLAVNMAGSVS-SAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPA 1386
L +T Y FR+ A + AG S + T +S P + P V L S I WE
Sbjct: 1019 RLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVP 1078
Query: 1387 DNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITL 1446
+G V Y + +L + S+ K +E ++ + GL+ Y F +
Sbjct: 1079 S--MKGDPVNYILQVLVGRE---------SEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
Query: 1447 CNSVGCVTSA---SGAGQTLAAAPAQLRPPLVKG 1477
C C+ ++ SGA AA Q ++ G
Sbjct: 1128 CRR--CLDTSQELSGAFSPSAAFVLQRSEVMLTG 1159
Score = 42.4 bits (98), Expect = 0.012
Identities = 92/481 (19%), Positives = 168/481 (34%), Gaps = 51/481 (10%)
Query: 1035 CVPSASHLDVNNLLGC---SKTPFQQPPPR--GQVQSSSAINLSWSPPDSPNAHWLT-YS 1088
C+ + H + L S P Q PPR G+ + ++L W P S + ++ YS
Sbjct: 649 CISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYS 707
Query: 1089 LLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVP 1148
+ E +E + ++ + +LLP T Y + + N G V+ T P
Sbjct: 708 VEMTEPEDVASEVYHGPELECTVG-NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP 766
Query: 1149 EGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIW 1208
G I V + W + + I +Y L + Y G +T I
Sbjct: 767 PGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELI-YHGTDTRFEIR 825
Query: 1209 NLVPFAKYDFSVQACTSGGC--LHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPP 1266
+L+P A+Y +QA G L + T A AP P E ++ P
Sbjct: 826 DLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAP-----DPVSTLCVLEEEPLDAYPD 880
Query: 1267 AELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTI 1326
+ +++ +E E + S + + ++ + + TM +
Sbjct: 881 SPSACLVLNWE----------EPCNNGSEILAYT--------IDLGDTSITVGNTTMHVM 922
Query: 1327 TGLEPYTKYEFRVLAVNMAGS-VSSAWVSERTGESAPVFMIPPSV--FPLSSYSLNISWE 1383
L P T Y R+ A+N G+ S ++ +T P+ +PP + SL + W
Sbjct: 923 KDLLPETTYRIRIQAINEIGAGPFSQFIKAKT---RPLPPLPPRLECAAAGPQSLKLKWG 979
Query: 1384 KPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFT 1443
+ + Y + + + + + +Y V+ L + Y F
Sbjct: 980 DSNSKTHAAEDIVYTLQLEDRN----------KRFISIYRGPSHTYKVQRLTEFTCYSFR 1029
Query: 1444 ITLCNSVG-CVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQL 1502
I + G S + T + P ++ P V + + + W + G Y L
Sbjct: 1030 IQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYIL 1089
Query: 1503 E 1503
+
Sbjct: 1090 Q 1090
Score = 40.4 bits (93), Expect = 0.046
Identities = 52/186 (27%), Positives = 73/186 (39%), Gaps = 23/186 (12%)
Query: 1329 LEPYTKYEFRVLAV--NMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPA 1386
L P T Y RV A+ ++ GS S VS T AP PP + S SL + W+ P
Sbjct: 345 LRPATDYHVRVYAMYNSVKGSCSEP-VSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI 403
Query: 1387 DNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITL 1446
DN K+ Y + ++ + S F Q ++ + L P Y F +
Sbjct: 404 DN--GSKITNYLLEW--DEGKRNS---GFRQCFFGSQKH---CKLTKLCPAMGYTFRLAA 453
Query: 1447 CNSVGCVTSASGAGQ-----TLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPI-Y 1500
N +G SG Q TL P P + T + L+W PE + I Y
Sbjct: 454 RNDIG----TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITY 509
Query: 1501 QLERRE 1506
LE +E
Sbjct: 510 TLEIQE 515
>gi|205360932 fibronectin type III domain containing 3B [Homo sapiens]
Length = 1204
Score = 145 bits (367), Expect = 8e-34
Identities = 218/900 (24%), Positives = 342/900 (38%), Gaps = 107/900 (11%)
Query: 3971 PWAQATSAHSVLLNWTKPES----PNGIISH---YRVVYQERPDDPTFNSPTVHAFTVKG 4023
P A +V+L+W P P+ +S Y V ++ D + G
Sbjct: 282 PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYK------IIYSG 335
Query: 4024 TSHQAHLYGLEPFTTYRIGVVAANHA--GEILSPWTLIQTLESSPSGLRNFIVEQKENGR 4081
+ +L L P T Y + V A ++ G P + + + + ++
Sbjct: 336 EELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKS-- 393
Query: 4082 ALLLQWSEPMRTNGVIKTYNIFSDGFLEYSGLNRQFL-------FRRLDPFTLYTLTLEA 4134
+L LQW P+ I Y + D SG + F +L P YT L A
Sbjct: 394 SLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
Query: 4135 CTRAGCA-HSAPQPLWTDEAPPDSQLAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRR 4193
G + +S +T P AP + T V L WS+P + + EVI
Sbjct: 454 RNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPE----EVITY 509
Query: 4194 CFEGKAWGNQTIQADEK--IVFTEYNTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCS 4251
E IQ DE + +Y E T + L+ TQ ++++ N+ G +C
Sbjct: 510 TLE--------IQEDENDNLFHPKYTGEDLTCTVKN--LKRSTQYKFRLTASNTEGKSCP 559
Query: 4252 SWNVVRTLQAPPEGLSPPVISYVS--MNPQKLLISWIPPEQSNGI-IQSYRLQRNE---- 4304
S +V T P+ PP V + + W PP+ + G I Y L+ +
Sbjct: 560 SEVLVCTTS--PDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSE 617
Query: 4305 -MLYPFSFDPVTFNYTDEELLPFSTYSYALQACTSGG---CSTSKPTSITTLEAAPSEVS 4360
+ ++ YT L P + Y ++GG CS S P + TL AP +
Sbjct: 618 ANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLP--VRTLSIAPGQCR 675
Query: 4361 PPD-LWAVSATQMNVCWSPPTVQNG-KITKYLVRYDNKESLA-----GQGLCLLVSHLQP 4413
PP L ++++ W P ++G ++++Y V E +A G L V +L P
Sbjct: 676 PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLP 735
Query: 4414 YSQYNFSLVACTNGGCTASVSKSAWTMEALPENM-DSPTLQVTGSESIEITWKPPRNPNG 4472
+ Y F + A +GG S T A P +P + T + + W+ P +
Sbjct: 736 GTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGA 795
Query: 4473 QIRSYELR-----RDGTIVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDR 4526
I Y L ++Y G +TR+ L P +Y + A N G G S LV +
Sbjct: 796 DISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQ 855
Query: 4527 TSPSAPSGM--------EPPKLQARGPQEILV-NWDPPVRTNGDIINYTLFIRELFERET 4577
T SAP + EP P LV NW+ P +I+ YT+ + + T
Sbjct: 856 TPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGD-----T 910
Query: 4578 KIIHINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCAS-SDWTFIQTPEIAPLMQP 4636
I NTT +++ L P Y IRIQA +G S + +T + PL
Sbjct: 911 SITVGNTT-------MHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL--- 960
Query: 4637 PPHLEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTS 4696
PP LE A G Q ++ L W N K E + + R + IY G S +
Sbjct: 961 PPRLEC--AAAGPQ-SLKLKWG---DSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHT 1014
Query: 4697 FIDSELLPFTEYEYQVWAVNSAGKAPSS--WTWCRTGPAPPEGLRAPTFHVISSTQA-VV 4753
+ L FT Y +++ A + AG+ P S +T+ T PP ++AP + ++
Sbjct: 1015 YKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPT-IKAPRVTQLEGNSCEIL 1073
Query: 4754 NISAPGKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNC 4813
+ P V+ + +G + GLQ T+Y V C C C
Sbjct: 1074 WETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRV--CACRRC 1131
Score = 126 bits (316), Expect = 6e-28
Identities = 213/912 (23%), Positives = 345/912 (37%), Gaps = 127/912 (13%)
Query: 3496 EDVPQGVSPPTWTKIDNLED-TIVLNWRKPIQSNG--------PIIYYILL----RNGIE 3542
+D+ G+ P ++ N++ +VL+W P+ + P Y + L R+G
Sbjct: 273 QDILSGIEKP---QVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKY 329
Query: 3543 R--FRGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVAATTQG-VPESILPPSIT 3599
+ + G L + K+ ++P +Y ++ A + + S+ V+ TT PE PP +
Sbjct: 330 KIIYSGEELECNLKD-LRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLA 388
Query: 3600 ALSAVALHLSWSVPEKSNGVIKEYQIR----QVGKGLIHTDTTDRRQHTVTGLQPYTNYS 3655
S +L L W P + I Y + + G ++ +T L P Y+
Sbjct: 389 HRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYT 448
Query: 3656 FTLTACTSAGCTS-SEPFLGQTLQAAPEGVWVTPRHIIINSTTVELYWSLPE--KPNGLV 3712
F L A G + S+ + TL P+ + PR + T V L WS PE P ++
Sbjct: 449 FRLAARNDIGTSGYSQEVVCYTLGNIPQ-MPSAPRLVRAGITWVTLQWSKPEGCSPEEVI 507
Query: 3713 S---QYQLSRNGNLL---FLGGSEEQNFTDKNLEPNSRYTYKLEVKTGGGSSASDDYIVQ 3766
+ + Q N NL + G E+ T KNL+ +++Y ++L G S + +V
Sbjct: 508 TYTLEIQEDENDNLFHPKYTG--EDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVC 565
Query: 3767 TPMSTPEEIYPPYNITVIGP---YSIFVAWIPPGILIPEIPVEYNVLLNDGSVTPLAFSV 3823
T ++P+ PP V GP + V W PP ++Y + + DG+ + V
Sbjct: 566 T--TSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEV 623
Query: 3824 GHHQSTL---LENLTPFTQYEIRIQAC---QNGSCGVSSRMFVKTPEAAPMDLNSP-VLK 3876
+ S +L P T Y++R AC G S + V+T AP P VL
Sbjct: 624 AYSGSATEYTFTHLKPGTLYKLR--ACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLG 681
Query: 3877 ALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVLFVWSEGALEFMDEGDTLRPFT 3936
+ ++W P +G ++ + E E V G G+ L P T
Sbjct: 682 RPKHKEVHLEWDVPASESGCEVSEYSVEMT---EPEDVASEVYHGPELECTVGNLL-PGT 737
Query: 3937 LYEYRVRACNSKG-SVESLWSLTQTLEAPPQDFPAPWAQATSAHSVLLNWTKPESPNGII 3995
+Y +RVRA N G S S T PP AP T VL+ W P+S I
Sbjct: 738 VYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADI 797
Query: 3996 SHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYGLEPFTTYRIGVVAANHAGE-ILS 4054
S YR+ + E D+ + GT + + L P Y + A N AG S
Sbjct: 798 SEYRLEWGE--DEESLE------LIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYS 849
Query: 4055 PWTLIQTLESSPSGLRNFIVEQKE--------NGRALLLQWSEPMRTNGVIKTYNIFSDG 4106
L QT S+P + V ++E L+L W EP I Y I
Sbjct: 850 ELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGD 909
Query: 4107 FLEYSGLNRQFLFRRLDPFTLYTLTLEACTRAGC--------AHSAPQPLWTDEAPPDSQ 4158
G + + L P T Y + ++A G A + P P PP +
Sbjct: 910 TSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLP----PLPPRLE 965
Query: 4159 LAPTVHSVKSTSVELSWSEPVNPNGKIIRYEVIRRCFEGKAWGNQTIQADEKIVFTEYNT 4218
A + S++L W + N A E IV+T
Sbjct: 966 CA----AAGPQSLKLKWGD-----------------------SNSKTHAAEDIVYTLQLE 998
Query: 4219 ERN----------TFMYNDTGLQPWTQCEYKIYTWNSAGH-TCSSWNVVRTLQAPPEGLS 4267
+RN + Y L +T ++I + AG S T ++ P +
Sbjct: 999 DRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIK 1058
Query: 4268 PPVISYVSMNPQKLLISWIPP---EQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELL 4324
P ++ + N ++L +P + N I+Q + +E + + TF + L
Sbjct: 1059 APRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKGEEATFQISG--LQ 1116
Query: 4325 PFSTYSYALQAC 4336
+ Y + + AC
Sbjct: 1117 TNTDYRFRVCAC 1128
Score = 123 bits (309), Expect = 4e-27
Identities = 185/797 (23%), Positives = 306/797 (38%), Gaps = 78/797 (9%)
Query: 4256 VRTLQAPPEGLSPPVISYVSMNPQKLLISWIPP-------EQSNGIIQSYRLQRNEM--- 4305
V+ +Q G+ P +S ++ + +++SW PP SY + ++
Sbjct: 269 VKRVQDILSGIEKPQVS--NIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRD 326
Query: 4306 -LYPFSFDPVTFNYTDEELLPFSTYS---YALQACTSGGCSTSKPTSITTLEAAPSEVSP 4361
Y + ++L P + Y YA+ G CS +P S TT AP P
Sbjct: 327 GKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCS--EPVSFTTHSCAPECPFP 384
Query: 4362 PDLWAVSATQMNVCWSPPTVQNGKITKYLVRYDNKESLAGQGLCLL-------VSHLQPY 4414
P L S + + + W P KIT YL+ +D + +G C ++ L P
Sbjct: 385 PKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPA 444
Query: 4415 SQYNFSLVACTNGGCTA-SVSKSAWTMEALPENMDSPTLQVTGSESIEITWKPPR--NPN 4471
Y F L A + G + S +T+ +P+ +P L G + + W P +P
Sbjct: 445 MGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPE 504
Query: 4472 GQIR-SYELRRDGT-----IVYTGLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVK 4524
I + E++ D YTG + L +Y + +TASN++G S ++
Sbjct: 505 EVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLV 564
Query: 4525 DRTSPSAPSGMEPPKLQARGP---QEILVNWDPPVRTNG-DIINYTLFIRELFERETKII 4580
TSP P P + +GP V WDPP G +I+ Y L E+ + ++
Sbjct: 565 CTTSPDRPG--PPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLL---EITDGNSEAN 619
Query: 4581 HINTTHNSFGMQSYIVNQLKPFHRYEIRIQACTTLGCAS-SDWTFIQTPEIAPLMQPPPH 4639
++ + Y LKP Y++R +T G + S+ ++T IAP PP
Sbjct: 620 QWEVAYSGSATE-YTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR 678
Query: 4640 LEVQMAPGGFQPTVSLLWTGPLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFID 4699
+ + V L W P +G E+ + + +Y+G
Sbjct: 679 VLGRPK----HKEVHLEWDVPASESG----CEVSEYSVEMTEPEDVASEVYHGPELECTV 730
Query: 4700 SELLPFTEYEYQVWAVNSAGKAP-SSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAP 4758
LLP T Y ++V A+N G P S + T PP +AP +V +P
Sbjct: 731 GNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESP 790
Query: 4759 GKPNGIVSLYRLFSSSAHGAETVLSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGP 4818
+S YRL + ++ G T+ + L Y ++A FN GP
Sbjct: 791 DSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQA---FNQAGAGP 847
Query: 4819 TAELRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDS-ALP 4877
+EL P S + + TL + P P+ + L + C S L
Sbjct: 848 YSELVLCQTPAS--APDPVSTLCVLEEEPLDAYPDSPSACL---VLNWEEPCNNGSEILA 902
Query: 4878 CTPSQIETKYT-GLGQKASLGGLQPYTTYKLRVVAHNEVGSTASEWISFTTQKELPQYRA 4936
T +T T G + L P TTY++R+ A NE+G A + F K P
Sbjct: 903 YTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIG--AGPFSQFIKAKTRPLPPL 960
Query: 4937 PFSVD---SNLSVVCVNWSDTFLLNGQLKEYVLT----DGGRR---VYSGLDTTLYIPRT 4986
P ++ + + + W D+ ++ V T D +R +Y G T + R
Sbjct: 961 PPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRL 1020
Query: 4987 ADKT-FFFQVICTTDEG 5002
+ T + F++ ++ G
Sbjct: 1021 TEFTCYSFRIQAASEAG 1037
Score = 119 bits (298), Expect = 8e-26
Identities = 196/881 (22%), Positives = 311/881 (35%), Gaps = 145/881 (16%)
Query: 4110 YSGLNRQFLFRRLDPFTLYTLTLEAC---TRAGCAHSAPQPLWTDEAPPDSQLAPTVHSV 4166
YSG + + L P T Y + + A + C S P T P+ P +
Sbjct: 333 YSGEELECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTTHSCAPECPFPPKLAHR 390
Query: 4167 KSTSVELSWSEPVNPNGKIIRYEV----------IRRCFEGKAWGNQTIQADEKIVFTEY 4216
+S+ L W P++ KI Y + R+CF G + + + +T
Sbjct: 391 SKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFR 450
Query: 4217 NTERNTFMYNDTGLQPWTQCEYKIYTWNSAGHTCSSWNVVR------TLQ-APPEGLSPP 4269
RN D G ++Q E YT + S+ +VR TLQ + PEG SP
Sbjct: 451 LAARN-----DIGTSGYSQ-EVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPE 504
Query: 4270 VISYVSMNPQKLLISWIPPEQSNGIIQSYRLQRNEMLYPFSFDPVTFNYTDEELLPFSTY 4329
+ ++ Q+ N+ L+ + T + L + Y
Sbjct: 505 EVITYTLEIQE--------------------DENDNLFHPKYTGEDLTCTVKNLKRSTQY 544
Query: 4330 SYALQACTSGGCSTSKPTSITTLEAAPSEVSPPDL----WAVSATQMNVCWSPPTVQNG- 4384
+ L A + G S P+ + +P PP V++ +V W PP G
Sbjct: 545 KFRLTASNTEGKSC--PSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGS 602
Query: 4385 KITKYLVRYDNKESLA--------GQGLCLLVSHLQPYSQYNFSLVACTNGGCT-ASVSK 4435
+I KYL+ + S A G +HL+P + Y + GG + S S
Sbjct: 603 EILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESL 662
Query: 4436 SAWTMEALPENMDSP-TLQVTGSESIEITWKPPRNPNG-QIRSYELRRD-----GTIVYT 4488
T+ P P L + + + W P + +G ++ Y + + VY
Sbjct: 663 PVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYH 722
Query: 4489 GLETRYRDFTLTPGVEYSYTVTASNSQG-GILSPLVKDRTSPSAPSGMEPPKLQARGPQE 4547
G E L PG Y + V A N G G S + + T+ P + P +
Sbjct: 723 GPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGC 782
Query: 4548 ILVNWDPPVRTNGDIINYTLFIRELFERETKIIHINTTHNSFGMQSYIVNQLKPFHRYEI 4607
+LV W+ P + DI Y L E E I H T + + L P +Y
Sbjct: 783 VLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTR-------FEIRDLLPAAQYCC 835
Query: 4608 RIQACTTLGCAS-SDWTFIQTPEIAP-------LMQPPPHLEVQMAPGGFQPTVSLLWTG 4659
R+QA G S+ QTP AP +++ P + P + L W
Sbjct: 836 RLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEP---LDAYPDSPSACLVLNWEE 892
Query: 4660 PLQPNGKVLYYELYRRQIATQPRKSNPVLIYNGSSTSFIDSELLPFTEYEYQVWAVNSAG 4719
P ++L Y + I G++T + +LLP T Y ++ A+N G
Sbjct: 893 PCNNGSEILAYTI----------DLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIG 942
Query: 4720 KAP-SSWTWCRTGPAPPEGLRAPTFHVISSTQAVVNISAPGKPNGIVSLYRLFSSSAHGA 4778
P S + +T P PP R + +A G P + + +S H A
Sbjct: 943 AGPFSQFIKAKTRPLPPLPPR-------------LECAAAG-PQSLKLKWGDSNSKTHAA 988
Query: 4779 ETV---------------LSEGMATQQTLHGLQAFTNYSIGVEACTCFNCCSKGPTAE-- 4821
E + + G + + L FT YS ++A + +GP +E
Sbjct: 989 EDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRIQAASE---AGEGPFSETY 1045
Query: 4822 -LRTHPAPPSGLSSPQIGTLASRTASFRWSPPMFPNGVIHSYELQFHVACPPDSALPCTP 4880
T + P + +P++ L + W G +Y LQ V
Sbjct: 1046 TFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVG---------RE 1096
Query: 4881 SQIETKYTGLGQKASLGGLQPYTTYKLRVVAHNEVGSTASE 4921
S+ + Y G + GLQ T Y+ RV A T+ E
Sbjct: 1097 SEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQE 1137
Score = 116 bits (291), Expect = 5e-25
Identities = 187/780 (23%), Positives = 303/780 (38%), Gaps = 75/780 (9%)
Query: 2019 LTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPP-VAKSLPSSLLLSWNP 2077
L L P +Y V + A + S ++ +T AP+ PP +A SSL L W
Sbjct: 342 LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKSSLTLQWKA 401
Query: 2078 PKKANGIITQYCLYMDG-------RLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTN 2130
P IT Y L D R + GS+++ +T L + F L+A +G +
Sbjct: 402 PIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSG 461
Query: 2131 -SSWVLLYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGI-LERYVLYMSNHTHDFT 2188
S V+ YT P+ +P L + +QW +P S + Y L + +D
Sbjct: 462 YSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQEDEND-N 520
Query: 2189 IWSVIYNSTELFQDHMLQYVLPGNKYLIKLGAC-TGGGCTVSEASEALTDEDIPEGVPAP 2247
++ Y +L ++ + +Y +L A T G SE T D P P
Sbjct: 521 LFHPKYTGEDL--TCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRP 578
Query: 2248 KAHS-YSPDSFNVSWTEPEYPNGV-ITSYGLYL-DGILIHNSSELSYRA----YGFA--- 2297
+ F+V W P+ G I Y L + DG N E++Y Y F
Sbjct: 579 LVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLK 638
Query: 2298 PWSLHSFRVQACTAKGCA-LGPLVENRTLE-APPEGTVNVFVKTQGSRKAHVRWEAPFRP 2355
P +L+ R + G + + RTL AP + + ++ H+ W+ P
Sbjct: 639 PGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE 698
Query: 2356 NGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNIS 2415
+G V + +P +V +Y G E L + L+P T Y +V
Sbjct: 699 SGC---EVSEYSVEMTEPE-------DVASEVYHGPE--LECTVGNLLPGTVYRFRVRAL 746
Query: 2416 NSQG----SLITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWSTPARNNAPGSPRYQL 2471
N G S +++ T A PPG P +S + V W +P + A S Y+L
Sbjct: 747 NDGGYGPYSDVSEITTAAGPPGQCKA---PCISCTPDGCVLVGWESPDSSGADIS-EYRL 802
Query: 2472 QMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLVASNGFGSA-HSSWIPFMTAE 2530
+ + + LEL + +E+ DL P +Y RL A N G+ +S + T
Sbjct: 803 EWGEDEES---LELIYH-GTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPA 858
Query: 2531 DKPGPVVPPILL---------DVKSRMMLVTWQHPRKSNGVITHYNIYLHGRLYLRTPGN 2581
P PV +L D S +++ W+ P + I Y I L T GN
Sbjct: 859 SAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSI--TVGN 916
Query: 2582 VTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWT----LPGAPEGIPSPELFSDTP 2637
T + L P T Y+ +++A G P SQ + LP P P E + P
Sbjct: 917 TTMHVMKDLLPETTYRIRIQAINEIGAG--PFSQFIKAKTRPLPPLP---PRLECAAAGP 971
Query: 2638 TSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYE 2697
S+ + W E+ +++ + + + SH+ K L+ +T Y
Sbjct: 972 QSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTY----KVQRLTEFTCYS 1027
Query: 2698 YRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTWKPPLIQNGDILSY 2757
+R+ ++ G S +T S P ++ P VT LE ++ ++ W+ GD ++Y
Sbjct: 1028 FRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNY 1087
Score = 109 bits (273), Expect = 6e-23
Identities = 194/856 (22%), Positives = 324/856 (37%), Gaps = 84/856 (9%)
Query: 2146 VDSPVLTVLDSRTIHIQWKQPRKIS-------GILERYVLYMSNHTHDFTIWSVIYNSTE 2198
++ P ++ + +R + + W P +S Y + +S+ D + +IY+ E
Sbjct: 279 IEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGK-YKIIYSGEE 337
Query: 2199 LFQDHMLQYVLPGNKYLIKLGACTG---GGCTVSEASEALTDEDIPEGVPAPKAHSYSPD 2255
L + L+ + P Y +++ A G C SE T PE PK S
Sbjct: 338 L--ECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTTHSCAPECPFPPKLAHRSKS 393
Query: 2256 SFNVSWTEPEYPNGVITSYGLYLDGILIHNS-------SELSYRAYGFAPWSLHSFRVQA 2308
S + W P IT+Y L D ++ S+ + P ++FR+ A
Sbjct: 394 SLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
Query: 2309 CTAKGCA-LGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTHSVLFTG 2367
G + V TL P+ + G ++W +P G V+ T
Sbjct: 454 RNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWS---KPEGCSPEEVI-TY 509
Query: 2368 IFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGSLITDPIT 2427
+ N+ N+ Y+GE+ L + L T Y ++ SN++G + P
Sbjct: 510 TLEIQEDEND----NLFHPKYTGED--LTCTVKNLKRSTQYKFRLTASNTEGK--SCPSE 561
Query: 2428 IAMPPGAPDGVLPPRL----SSATPTSLQVVWSTPARNNAPGSPRYQLQMRSGDSTHGFL 2483
+ + +PD PP T V W P N +Y L++ G+S
Sbjct: 562 VLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
Query: 2484 ELFSNPSASLSYEVSDLQPYTEYMFRLVA-SNGFGSAHSSWIPFMTAEDKPGPVVPPILL 2542
E+ + SA+ Y + L+P T Y R S G S S +P T PG PP +L
Sbjct: 622 EVAYSGSAT-EYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVL 680
Query: 2543 D-VKSRMMLVTWQHPRKSNGV-ITHYNIYLHGRLYLRTP---GNVTNCTVMHLHPYTAYK 2597
K + + + W P +G ++ Y++ + + + G CTV +L P T Y+
Sbjct: 681 GRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYR 740
Query: 2598 FQVEACTSKGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISWQPPTHPNGLVENF 2657
F+V A G + + T G P +P + V++ W+ P +
Sbjct: 741 FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS-- 798
Query: 2658 TIERRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEV 2717
E R++ E+ +L + RF + L P +Y R+ G S V
Sbjct: 799 --EYRLEWGEDEESLELIYHGTDTRF--EIRDLLPAAQYCCRLQAFNQAGAGPYSELVLC 854
Query: 2718 TTRPSRPAGVQPPVVTVLEP-DA--------VQVTWKPPLIQNGDILSYEIHMPDPHITL 2768
T S P V V EP DA + + W+ P +IL+Y I + D IT+
Sbjct: 855 QTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITV 914
Query: 2769 TNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLS 2828
N T V+ L+P T Y + I A + G ++ + P +P + +
Sbjct: 915 GNTTMHVMKD----LLPETTYRIRIQAINEIGA--GPFSQFIKAKTRPLPPLPPRLECAA 968
Query: 2829 VIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLN-RWHNIYSGTQWLY 2887
P S + + W N E + +Q ED N R+ +IY G Y
Sbjct: 969 AGPQS---LKLKW---GDSNSKTHAAEDIVYTLQL-------EDRNKRFISIYRGPSHTY 1015
Query: 2888 EDKGLSRFTTYEYMLFVHNSVGFTP-SREVTVTTLAGLPERGANLTASVLNHTAIDVRWA 2946
+ + L+ FT Y + + + G P S T +T +P + L + ++ W
Sbjct: 1016 KVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILW- 1074
Query: 2947 KPTVQDLQGEVEYYTL 2962
TV ++G+ Y L
Sbjct: 1075 -ETVPSMKGDPVNYIL 1089
Score = 92.0 bits (227), Expect = 1e-17
Identities = 191/858 (22%), Positives = 320/858 (37%), Gaps = 97/858 (11%)
Query: 1893 STDSAVNCRGNDSI--LVYQGKEQSVYEGGLQPFTEYLYRVIASHEGGSVYSDWSRGRTT 1950
S + A++ +G D ++Y G+E L+P T+Y RV A + TT
Sbjct: 315 SYEVALSDKGRDGKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTT 374
Query: 1951 GAAPQSVPTPSRVRSLNGYSIEVTWDEPVVRG-VIEKYILKAYSEDSTRPPRMPSASAEF 2009
+ P P ++ + S+ + W P+ G I Y+L+ + E + S +
Sbjct: 375 HSCAPECPFPPKLAHRSKSSLTLQWKAPIDNGSKITNYLLE-WDEG-----KRNSGFRQC 428
Query: 2010 VNTSNLTGILTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPP-VAKSLP 2068
S LT L P Y L A G + S + T PQ P + ++
Sbjct: 429 FFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGI 488
Query: 2069 SSLLLSWNPPK--KANGIITQYCLYM----DGRLI---YSGSEENYTVTDLAVFTPHQFL 2119
+ + L W+ P+ +IT Y L + + L Y+G + TV +L T ++F
Sbjct: 489 TWVTLQWSKPEGCSPEEVIT-YTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFR 547
Query: 2120 LSACTHVGCTNSSWVLLYTAQLPPEHVDSP----VLTVLDSRTIHIQWKQPRKISGI-LE 2174
L+A G + S VL+ T P+ P V + S ++W P+ G +
Sbjct: 548 LTASNTEGKSCPSEVLVCTTS--PDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEIL 605
Query: 2175 RYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGAC---TGGGCTVSEA 2231
+Y+L +++ + W V Y+ + ++ ++ PG Y KL AC TGG SE+
Sbjct: 606 KYLLEITDGNSEANQWEVAYSGSA--TEYTFTHLKPGTLY--KLRACCISTGGHSQCSES 661
Query: 2232 SEALTDEDIPEGVPAPKAHSY-SPDSFNVSWTEPEYPNGV-ITSYGLYLD-----GILIH 2284
T P P+ ++ W P +G ++ Y + + ++
Sbjct: 662 LPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVY 721
Query: 2285 NSSELSYRAYGFAPWSLHSFRVQACTAKGCALGP---LVENRTLEAPPEGTVNVFVKTQG 2341
+ EL P +++ FRV+A G GP + E T PP +
Sbjct: 722 HGPELECTVGNLLPGTVYRFRVRALNDGG--YGPYSDVSEITTAAGPPGQCKAPCISCTP 779
Query: 2342 SRKAHVRWEAPFRPNGLLTHSVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDG 2401
V WE+P ++ L G + +L +++Y G +T I
Sbjct: 780 DGCVLVGWESPDSSGADISEYRLEWG-------EDEESL----ELIYHGTDTRF--EIRD 826
Query: 2402 LVPFTNYTVQVNISNSQGS-LITDPITIAMPPGAPDG-----VLPPRLSSATPTS----L 2451
L+P Y ++ N G+ ++ + P APD VL A P S L
Sbjct: 827 LLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACL 886
Query: 2452 QVVWSTPARNNAPGSPRYQLQMRSGDSTHGFLELFSNPSASLSYEVSDLQPYTEYMFRLV 2511
+ W P N GS + GD++ + + + DL P T Y R+
Sbjct: 887 VLNWEEPCNN---GSEILAYTIDLGDTS-------ITVGNTTMHVMKDLLPETTYRIRIQ 936
Query: 2512 ASNGFGSAHSSWIPFMTAEDKPGPVVPPIL--LDVKSRMMLVTWQHPRKSNGVITH--YN 2567
A N G+ S F+ A+ +P P +PP L + + + W Y
Sbjct: 937 AINEIGAGPFS--QFIKAKTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYT 994
Query: 2568 IYLHGR-----LYLRTPGNVTNCTVMHLHPYTAYKFQVEACTSKGCSLSPESQTVWTLPG 2622
+ L R R P + V L +T Y F+++A + G E+ T T
Sbjct: 995 LQLEDRNKRFISIYRGPSHTYK--VQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKS 1052
Query: 2623 APEGIPSPELFSDTPTSVIISWQPPTHPNGLVENFTIERRVKGKEEVTTLVTLPRSHSMR 2682
P I +P + S I W+ G N+ ++ V + E + +
Sbjct: 1053 VPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY---KGEEAT 1109
Query: 2683 FIDKTSALSPWTKYEYRV 2700
F + S L T Y +RV
Sbjct: 1110 F--QISGLQTNTDYRFRV 1125
Score = 89.0 bits (219), Expect = 1e-16
Identities = 137/613 (22%), Positives = 230/613 (37%), Gaps = 54/613 (8%)
Query: 3465 NLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDN--LEDTIVLNWR 3522
NLK Y++R++A N+ G+ V T P PPT + + W
Sbjct: 537 NLKRSTQYKFRLTASNTEGKSCPSEVLVCTTS--PDRPGPPTRPLVKGPVTSHGFSVKWD 594
Query: 3523 KPIQSNGPII--YYILLRNGIERFRGTSLSFSDKEGIQPFQEYS----YQLKACTVA--G 3574
P + G I Y + + +G +++S F Y+L+AC ++ G
Sbjct: 595 PPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGG 654
Query: 3575 CATSSKVVAATTQGV-PESILPPSITAL-SAVALHLSWSVPEKSNGV-IKEYQIRQVGKG 3631
+ S+ + T + P PP + +HL W VP +G + EY +
Sbjct: 655 HSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPE 714
Query: 3632 LIHTDT--TDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPEGVWVTPR 3689
+ ++ + TV L P T Y F + A G T A P G P
Sbjct: 715 DVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPC 774
Query: 3690 HIIINSTTVELYWSLPEKPNGLVSQYQL---SRNGNLLFLGGSEEQNFTDKNLEPNSRYT 3746
V + W P+ +S+Y+L +L + + F ++L P ++Y
Sbjct: 775 ISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYC 834
Query: 3747 YKLEV-KTGGGSSASDDYIVQTPMSTPEEI-------YPPYNITVIGPYSIFVA-WIPPG 3797
+L+ G S+ + QTP S P+ + P + P + V W P
Sbjct: 835 CRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPC 894
Query: 3798 ILIPEIPVEYNVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQNGSCGVSSR 3857
EI + Y + L D S+T VG+ ++++L P T Y IRIQA G S+
Sbjct: 895 NNGSEI-LAYTIDLGDTSIT-----VGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQ 948
Query: 3858 MFVKTPEAAPMDLNSPVLK--ALGSACIEIKWMPPEKPNGIIINYFIYRRPAGIEEESVL 3915
F+K + P+ P L+ A G +++KW + +Y +E+ +
Sbjct: 949 -FIKA-KTRPLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAED-IVY--TLQLEDRNKR 1003
Query: 3916 FVWSEGALEFMDEGDTLRPFTLYEYRVRACN--SKGSVESLWSLTQTLEAPPQDFPAPWA 3973
F+ + L FT Y +R++A + +G ++ + T PP AP
Sbjct: 1004 FISIYRGPSHTYKVQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPP-TIKAPRV 1062
Query: 3974 QATSAHSVLLNW-TKPESPNGIISHYRVVYQERPDDPTFNSPTVHAFTVKGTSHQAHLYG 4032
+S + W T P +++ V R + + KG + G
Sbjct: 1063 TQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESE--------YKQVYKGEEATFQISG 1114
Query: 4033 LEPFTTYRIGVVA 4045
L+ T YR V A
Sbjct: 1115 LQTNTDYRFRVCA 1127
Score = 82.0 bits (201), Expect = 1e-14
Identities = 134/633 (21%), Positives = 247/633 (39%), Gaps = 60/633 (9%)
Query: 1909 YQGKEQSVYEGGLQPFTEYLYRVIASH-EGGSVYSDWSRGRTTGAAPQSVPTPSRVRSLN 1967
Y G++ + L+ T+Y +R+ AS+ EG S S+ T+ P P +
Sbjct: 526 YTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCTTSPDRPGPPTRPLVKGPVT 585
Query: 1968 GYSIEVTWDEPVVRGVIE--KYILK---AYSEDSTRPPRMPSASAEFVNTSNLTGILTGL 2022
+ V WD P G E KY+L+ SE + ++ E+ T L
Sbjct: 586 SHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVAYSGSATEYT--------FTHL 637
Query: 2023 LPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEVQPPVAKSLPS--SLLLSWNPPKK 2080
P Y + + G ++ S +L + T AP + +PP P + L W+ P
Sbjct: 638 KPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPAS 697
Query: 2081 ANGI-ITQYCLYMD-----GRLIYSGSEENYTVTDLAVFTPHQFLLSACTHVGCTNSSWV 2134
+G +++Y + M +Y G E TV +L T ++F + A G S V
Sbjct: 698 ESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDV 757
Query: 2135 L-LYTAQLPPEHVDSPVLTVLDSRTIHIQWKQPRKISGILERYVLYMSNHTHDFTIWSVI 2193
+ TA PP +P ++ + + W+ P + Y L + I
Sbjct: 758 SEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLEL---I 814
Query: 2194 YNSTELFQDHMLQYVLPGNKYLIKLGACTGGGC----------TVSEASEALTDEDIPEG 2243
Y+ T+ + ++ +LP +Y +L A G T + A + ++ + E
Sbjct: 815 YHGTDTRFE--IRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEE 872
Query: 2244 VPAPKAHSYSPDSFNV-SWTEPEYPNGVITSYGLYLDGILIHNSSELSYRAYGFAPWSLH 2302
P A+ SP + V +W EP I +Y + L I + + P + +
Sbjct: 873 EPLD-AYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTY 931
Query: 2303 SFRVQACTAKGCA-LGPLVENRTLEAPPEGTVNVFVKTQGSRKAHVRWEAPFRPNGLLTH 2361
R+QA G ++ +T PP + G + ++W + TH
Sbjct: 932 RIRIQAINEIGAGPFSQFIKAKTRPLPPLPP-RLECAAAGPQSLKLKWG----DSNSKTH 986
Query: 2362 SVLFTGIFYVDPVGNNYTLLNVTKVMYSGEETNLWVLIDGLVPFTNYTVQVNISNSQGS- 2420
+ ++ + N +++ Y G V L FT Y+ ++ ++ G
Sbjct: 987 AAEDI-VYTLQLEDRNKRFISI----YRGPSHTYKV--QRLTEFTCYSFRIQAASEAGEG 1039
Query: 2421 LITDPITIAMPPGAPDGVLPPRLSSATPTSLQVVWST-PARNNAPGSPRYQLQMRSGDST 2479
++ T + P + PR++ S +++W T P+ P + Y LQ+ G +
Sbjct: 1040 PFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVN--YILQVLVGRES 1097
Query: 2480 HGFLELFSNPSASLSYEVSDLQPYTEYMFRLVA 2512
+ +++ A+ +++S LQ T+Y FR+ A
Sbjct: 1098 E-YKQVYKGEEAT--FQISGLQTNTDYRFRVCA 1127
Score = 78.2 bits (191), Expect = 2e-13
Identities = 130/549 (23%), Positives = 202/549 (36%), Gaps = 49/549 (8%)
Query: 2626 GIPSPELFSDTPTSVIISWQPPTH-----PNGLVENFTIERRV--KGKEEVTTLVTLPRS 2678
GI P++ + +V++SW PP +GL ++ E + KG++ ++
Sbjct: 278 GIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEE 337
Query: 2679 HSMRFIDKTSALSPWTKYEYRVLMSTLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPD 2738
D L P T Y RV + S V TT P PP +
Sbjct: 338 LECNLKD----LRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSKS 393
Query: 2739 AVQVTWKPPLIQNGDILSYEIHMPDPHITLTNVTSAVLSQK---VTHLIPFTNYSVTIVA 2795
++ + WK P+ I +Y + + SQK +T L P Y+ + A
Sbjct: 394 SLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFRLAA 453
Query: 2796 CS--GGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSESYVVISWQPPSKPNGPNLR 2853
+ G +GY S T +PQ ++ ++V + W SKP G +
Sbjct: 454 RNDIGTSGY------SQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQW---SKPEGCSPE 504
Query: 2854 YELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTPS 2913
I L E+ N +H Y+G K L R T Y++ L N+ G +
Sbjct: 505 -----EVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCP 559
Query: 2914 REVTVTTLA----GLPERGANLTASVLNHTAIDVRWAKPTVQDLQG-EVEYYTLFWSSAT 2968
EV V T + G P R + V +H V+W P +D G E+ Y L +
Sbjct: 560 SEVLVCTTSPDRPGPPTRPL-VKGPVTSH-GFSVKWDPP--KDNGGSEILKYLLEITDGN 615
Query: 2969 SNDS---LKILPDVNSHVIGHLKPNTEYWI-FISVFNGVHSINSAGLHATTCDGEPQGML 3024
S + + + HLKP T Y + + G HS S L T P
Sbjct: 616 SEANQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCR 675
Query: 3025 PPEVV-IINSTAVRVIWTSPSNPNGV-VTEYSIYVNNKLYKTGMNVPGSFI---LRDLSP 3079
PP V+ V + W P++ +G V+EYS+ + G + + +L P
Sbjct: 676 PPRVLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLP 735
Query: 3080 FTIYDIQVEVCTIYACVK-SNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNG 3138
T+Y +V S+ ++ITT P P I + + W SP
Sbjct: 736 GTVYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGA 795
Query: 3139 IILGYDLLW 3147
I Y L W
Sbjct: 796 DISEYRLEW 804
Score = 67.8 bits (164), Expect = 3e-10
Identities = 110/460 (23%), Positives = 164/460 (35%), Gaps = 55/460 (11%)
Query: 1059 PPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQYPYSIQYFLD-TDLLP 1117
PP+ +S S++ L W P + Y L D + + Q + Q T L P
Sbjct: 384 PPKLAHRSKSSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
Query: 1118 YTKYSYYIETTNVHG----STRSVAVTYKTKPGVPEGNLTLSYIIPIGSDSVTLTWTTLS 1173
Y++ + N G S V T P +P ++ G VTL W+
Sbjct: 444 AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA----PRLVRAGITWVTLQWSKPE 499
Query: 1174 NQSGP-IEKYILSCAPLAGGQPC-VSYEGHETSATIWNLVPFAKYDFSVQACTSGGCLHS 1231
S + Y L Y G + + T+ NL +Y F + A + G S
Sbjct: 500 GCSPEEVITYTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEG--KS 557
Query: 1232 LPITVTTAQAPPQRLSPPKMQ----KISSTELHVEWSPPAELNGI-IIRYELYMRRLRST 1286
P V P R PP ++S V+W PP + G I++Y L
Sbjct: 558 CPSEVLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLL-------- 609
Query: 1287 KETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG 1346
E T S Q W E A T T T L+P T Y+ R ++ G
Sbjct: 610 -EITDGNSEANQ---W-----------EVAYSGSATEYTFTHLKPGTLYKLRACCISTGG 654
Query: 1347 -SVSSAWVSERTGESAPVFMIPPSVFPLSSYS-LNISWEKPADNVTRGKVVGYDINMLSE 1404
S S + RT AP PP V + +++ W+ PA + +V Y + M
Sbjct: 655 HSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKEVHLEWDVPASE-SGCEVSEYSVEMTEP 713
Query: 1405 QSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLA 1464
+ S++ H EL TV L P +Y F + N G + + T A
Sbjct: 714 ED-------VASEVYH---GPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSEITTA 763
Query: 1465 AA-PAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQLE 1503
A P Q + P + + + W P+ Y+LE
Sbjct: 764 AGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLE 803
Score = 64.3 bits (155), Expect = 3e-09
Identities = 135/652 (20%), Positives = 230/652 (35%), Gaps = 73/652 (11%)
Query: 2539 PILLDVKSRMMLVTWQHP-----RKSNGVITHYNIYL-------HGRLYLRTPGNVTNCT 2586
P + ++++R ++++W P +G+ Y+ + G+ + G C
Sbjct: 282 PQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGEELECN 341
Query: 2587 VMHLHPYTAYKFQVEACTS--KGCSLSPESQTVWTLPGAPEGIPSPELFSDTPTSVIISW 2644
+ L P T Y +V A + KG P S T + APE P+L + +S+ + W
Sbjct: 342 LKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSC--APECPFPPKLAHRSKSSLTLQW 399
Query: 2645 QPPTHPNGLVENFTIE-RRVKGKEEVTTLVTLPRSHSMRFIDKTSALSPWTKYEYRVLMS 2703
+ P + N+ +E K + H K + L P Y +R+
Sbjct: 400 KAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHC-----KLTKLCPAMGYTFRLAAR 454
Query: 2704 TLHGGTNSSAWVEVTTRPSRPAGVQPPVVTVLEPDAVQVTW-KPPLIQNGDILSYEIHMP 2762
G + S V T + P P + V + W KP ++++Y + +
Sbjct: 455 NDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITYTLEIQ 514
Query: 2763 D---PHITLTNVTSAVLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPT 2819
+ ++ T L+ V +L T Y + A S G +S P+ V T
Sbjct: 515 EDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTA-SNTEG------KSCPSEVLVCTT 567
Query: 2820 VPQNVG----PLSVIPLSESYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNR 2875
P G PL P++ + W PP G + LL ++ + N+
Sbjct: 568 SPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLE-------ITDGNSEANQ 620
Query: 2876 WHNIYSGTQWLYEDKGLSRFTTYEYMLFVHNSVGFTP-SREVTVTTLAGLPERGANLTAS 2934
W YSG+ Y L T Y+ ++ G + S + V TL+ P G
Sbjct: 621 WEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAP--GQCRPPR 678
Query: 2935 VL---NHTAIDVRWAKPTVQDLQGEVEYYTLFWSSATSNDSLKILPDVNSHVIGHLKPNT 2991
VL H + + W P + EY + P++ +G+L P T
Sbjct: 679 VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELEC-TVGNLLPGT 737
Query: 2992 EYWIFISVFN-GVHSINSAGLHATTCDGEPQGMLPPEVVIINSTAVRVIWTSPSNPNGVV 3050
Y + N G + S TT G P P + V V W SP + +
Sbjct: 738 VYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADI 797
Query: 3051 TEYSIYVNNKLYKTGMNVPGS---FILRDLSPFTIYDIQVE--------------VCTIY 3093
+EY + + G+ F +RDL P Y +++ +C
Sbjct: 798 SEYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTP 857
Query: 3094 ACVKSNGTQITTVEDTPSDIPTPTIRGITSRSLQIDWVSPRKPNGIILGYDL 3145
A + + +E+ P D + S L ++W P IL Y +
Sbjct: 858 ASAPDPVSTLCVLEEEPLDAYPDS----PSACLVLNWEEPCNNGSEILAYTI 905
Score = 64.3 bits (155), Expect = 3e-09
Identities = 99/445 (22%), Positives = 165/445 (37%), Gaps = 41/445 (9%)
Query: 1890 GCLSTDSAVNCRGNDSIL--VYQGKEQSVYEGGLQPFTEYLYRVIASHEGG-SVYSDWSR 1946
GC ++ +V + + VY G E G L P T Y +RV A ++GG YSD S
Sbjct: 700 GCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYRFRVRALNDGGYGPYSDVSE 759
Query: 1947 GRTTGAAPQSVPTPSRVRSLNGYSIEVTWDEPVVRGV-IEKYILKAYSEDSTRPPRMPSA 2005
T P P + +G + V W+ P G I +Y L+ + ED
Sbjct: 760 ITTAAGPPGQCKAPCISCTPDG-CVLVGWESPDSSGADISEYRLE-WGED--------EE 809
Query: 2006 SAEFVNTSNLTGI-LTGLLPFKNYAVTLTACTLAGCTESSHALNISTPQEAPQEV----- 2059
S E + T + LLP Y L A AG S + TP AP V
Sbjct: 810 SLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCV 869
Query: 2060 --QPPV---AKSLPSSLLLSWNPPKKANGIITQYCLYMDGRLIYSGSEENYTVTDLAVFT 2114
+ P+ S + L+L+W P I Y + + I G+ + + DL T
Sbjct: 870 LEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPET 929
Query: 2115 PHQFLLSACTHVGC-TNSSWVLLYTAQLPPEHVDSPVL--TVLDSRTIHIQWKQPRKISG 2171
++ + A +G S ++ T LPP P L +++ ++W +
Sbjct: 930 TYRIRIQAINEIGAGPFSQFIKAKTRPLPPL---PPRLECAAAGPQSLKLKWGDSNSKTH 986
Query: 2172 ILERYVLYMSNHTHDFTIWSVIYNSTELFQDHMLQYVLPGNKYLIKLGACT-GGGCTVSE 2230
E V + + S+ + ++ +Q + Y ++ A + G SE
Sbjct: 987 AAEDIVYTLQLEDRNKRFISIYRGPSHTYK---VQRLTEFTCYSFRIQAASEAGEGPFSE 1043
Query: 2231 ASEALTDEDIPEGVPAPKAHSYSPDSFNVSWTEPEYPNGVITSY------GLYLDGILIH 2284
T + +P + AP+ +S + W G +Y G + ++
Sbjct: 1044 TYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVY 1103
Query: 2285 NSSELSYRAYGFAPWSLHSFRVQAC 2309
E +++ G + + FRV AC
Sbjct: 1104 KGEEATFQISGLQTNTDYRFRVCAC 1128
Score = 64.3 bits (155), Expect = 3e-09
Identities = 69/258 (26%), Positives = 109/258 (42%), Gaps = 39/258 (15%)
Query: 3441 EEMCSSAEE----TIHTGSV-----NTYSYTDVNLKPYMTYEYRISAWNSYGRG-LSKAV 3490
EE C++ E TI G NT + +L P TY RI A N G G S+ +
Sbjct: 891 EEPCNNGSEILAYTIDLGDTSITVGNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFI 950
Query: 3491 RARTKEDVPQGVSPPTWTKIDNLEDTIVLNW---RKPIQSNGPIIYYILLRNGIERF--- 3544
+A+T+ P PP ++ L W + I+Y + L + +RF
Sbjct: 951 KAKTR---PLPPLPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISI 1007
Query: 3545 -RGTSLSFSDKEGIQPFQEYSYQLKACTVAGCATSSKVVA-ATTQGVPESILPPSITALS 3602
RG S ++ + + F YS++++A + AG S+ +TT+ VP +I P +T L
Sbjct: 1008 YRGPSHTYKVQR-LTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLE 1066
Query: 3603 AVALHLSWSVPEKSNG----------VIKEYQIRQVGKGLIHTDTTDRRQHTVTGLQPYT 3652
+ + W G V +E + +QV KG + ++GLQ T
Sbjct: 1067 GNSCEILWETVPSMKGDPVNYILQVLVGRESEYKQVYKG-------EEATFQISGLQTNT 1119
Query: 3653 NYSFTLTACTSAGCTSSE 3670
+Y F + AC TS E
Sbjct: 1120 DYRFRVCACRRCLDTSQE 1137
Score = 60.8 bits (146), Expect = 3e-08
Identities = 83/325 (25%), Positives = 126/325 (38%), Gaps = 54/325 (16%)
Query: 1192 GQPCVSYEGHETSATIWNLVPFAKYDFSVQAC---TSGGCLHSLPITVTTAQAPPQRLSP 1248
G+ + Y G E + +L P Y V A G C S P++ TT P+ P
Sbjct: 327 GKYKIIYSGEELECNLKDLRPATDYHVRVYAMYNSVKGSC--SEPVSFTTHSCAPECPFP 384
Query: 1249 PKMQKISSTELHVEWSPPAELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSF 1308
PK+ S + L ++W P + I Y L E ++SG+
Sbjct: 385 PKLAHRSKSSLTLQWKAPIDNGSKITNYLL-------------EWDEGKRNSGF------ 425
Query: 1309 VESANENALKPPQTMTTITGLEPYTKYEFRVLAVNMAG-SVSSAWVSERTGESAPVFMIP 1367
Q +T L P Y FR+ A N G S S V T + P
Sbjct: 426 -----RQCFFGSQKHCKLTKLCPAMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSA 480
Query: 1368 PSVFPLSSYSLNISWEKPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTA-KSQE 1426
P + + + W KP + + +V+ Y + + +++ L H ++
Sbjct: 481 PRLVRAGITWVTLQWSKP-EGCSPEEVITYTLEIQEDEN---------DNLFHPKYTGED 530
Query: 1427 LSYTVEGLKPYRIYEFTITLCNSVGCVTSASGAGQTLAAAPAQLRP-----PLVKG-INS 1480
L+ TV+ LK Y+F +T N+ G S + L + RP PLVKG + S
Sbjct: 531 LTCTVKNLKRSTQYKFRLTASNTEG----KSCPSEVLVCTTSPDRPGPPTRPLVKGPVTS 586
Query: 1481 TTIHLKWFPPEELNGPSPI--YQLE 1503
+KW PP++ NG S I Y LE
Sbjct: 587 HGFSVKWDPPKD-NGGSEILKYLLE 610
Score = 55.5 bits (132), Expect = 1e-06
Identities = 99/445 (22%), Positives = 175/445 (39%), Gaps = 52/445 (11%)
Query: 2725 AGVQPPVVTVLEPDAVQVTWKPPL-IQNGD------ILSYEIHMPDPHIT---LTNVTSA 2774
+G++ P V+ ++ AV ++W PP+ + G SYE+ + D +
Sbjct: 277 SGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYSGE 336
Query: 2775 VLSQKVTHLIPFTNYSVTIVACSGGNGYLGGCTESLPTYVTTHPTVPQNVGPLSVIPLSE 2834
L + L P T+Y V + A N G C+E P TTH P+ P + S+
Sbjct: 337 ELECNLKDLRPATDYHVRVYAMY--NSVKGSCSE--PVSFTTHSCAPECPFPPKLAHRSK 392
Query: 2835 SYVVISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNRWHNIYSGTQWLYEDKGLSR 2894
S + + W+ P NG + LL + + + + + G+Q + L
Sbjct: 393 SSLTLQWKAPI-DNGSKITNYLLE--------WDEGKRNSGFRQCFFGSQKHCKLTKLCP 443
Query: 2895 FTTYEYMLFVHNSVGFTP-SREVTVTTLAGLPERGANLTASVLNHTAIDVRWAKPTVQDL 2953
Y + L N +G + S+EV TL +P+ + T + ++W+KP
Sbjct: 444 AMGYTFRLAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSP 503
Query: 2954 QGEVEYYTLFWSSATSNDSL---KILPDVNSHVIGHLKPNTEYWIFISVFNGV-HSINSA 3009
+ EV YTL ND+L K + + + +LK +T+Y ++ N S S
Sbjct: 504 E-EVITYTL-EIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSE 561
Query: 3010 GLHATTCDGEPQGMLPPEVV-IINSTAVRVIWTSPSNPNG-VVTEYSIYV---NNKLYKT 3064
L TT P P V + S V W P + G + +Y + + N++ +
Sbjct: 562 VLVCTTSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQW 621
Query: 3065 GMNVPGS---FILRDLSPFTIYDIQVEVCTIYACVKSNG-------TQITTVEDTPSDIP 3114
+ GS + L P T+Y ++ C+ + G + T+ P
Sbjct: 622 EVAYSGSATEYTFTHLKPGTLYKLRA------CCISTGGHSQCSESLPVRTLSIAPGQCR 675
Query: 3115 TPTIRGITS-RSLQIDWVSPRKPNG 3138
P + G + + ++W P +G
Sbjct: 676 PPRVLGRPKHKEVHLEWDVPASESG 700
Score = 52.8 bits (125), Expect = 9e-06
Identities = 92/419 (21%), Positives = 146/419 (34%), Gaps = 56/419 (13%)
Query: 3465 NLKPYMTYEYRISAWNSYGRGLSKAVRARTKEDVPQGVSPPTWTKIDNLEDT----IVLN 3520
NL P Y +R+ A N G G V ++ PP K + T +++
Sbjct: 732 NLLPGTVYRFRVRALNDGGYGPYSDV-----SEITTAAGPPGQCKAPCISCTPDGCVLVG 786
Query: 3521 WRKPIQSNGPIIYYILLRNGIER-----FRGTSLSFSDKEGIQPFQEYSYQLKACTVAGC 3575
W P S I Y L E + GT F ++ + P +Y +L+A AG
Sbjct: 787 WESPDSSGADISEYRLEWGEDEESLELIYHGTDTRFEIRD-LLPAAQYCCRLQAFNQAGA 845
Query: 3576 ATSSKVVAATTQGVPESILPPSITAL-------------SAVALHLSWSVPEKSNGVIKE 3622
S++V T P S P T + L L+W P + I
Sbjct: 846 GPYSELVLCQT---PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILA 902
Query: 3623 YQIRQVGKGLIHTDTTDRRQHTVTGLQPYTNYSFTLTACTSAGCTSSEPFLGQTLQAAPE 3682
Y I + +TT H + L P T Y + A G F+ + P
Sbjct: 903 YTIDLGDTSITVGNTT---MHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPP 959
Query: 3683 GVWVTPR--HIIINSTTVELYW----SLPEKPNGLVSQYQL-SRNGNLLFLGGSEEQNFT 3735
+ PR +++L W S +V QL RN + + +
Sbjct: 960 ---LPPRLECAAAGPQSLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYK 1016
Query: 3736 DKNLEPNSRYTYKLEVKTGGGSSA-SDDYIVQTPMSTPEEIYPPYNITVIGPYSIFVAWI 3794
+ L + Y+++++ + G S+ Y T S P I P +T + S + W
Sbjct: 1017 VQRLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAP-RVTQLEGNSCEILW- 1074
Query: 3795 PPGILIPEI---PVEY--NVLLNDGSVTPLAFSVGHHQSTLLENLTPFTQYEIRIQACQ 3848
+P + PV Y VL+ S + G + + L T Y R+ AC+
Sbjct: 1075 ---ETVPSMKGDPVNYILQVLVGRESEYKQVYK-GEEATFQISGLQTNTDYRFRVCACR 1129
Score = 49.7 bits (117), Expect = 8e-05
Identities = 93/378 (24%), Positives = 144/378 (38%), Gaps = 51/378 (13%)
Query: 1045 NNLLGCSKTPFQQPPP-----RGQVQSSSAINLSWSPP-DSPNAHWLTYSL-LRDG-FEI 1096
+ +L C+ +P + PP +G V +S ++ W PP D+ + L Y L + DG E
Sbjct: 560 SEVLVCTTSPDRPGPPTRPLVKGPV-TSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEA 618
Query: 1097 YTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTR-SVAVTYKTKPGVPEGNLTLS 1155
E Y S + T L P T Y + G ++ S ++ +T P
Sbjct: 619 NQWEVAYSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPR 678
Query: 1156 YIIPIGSDSVTLTWTTLSNQSG-PIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPFA 1214
+ V L W +++SG + +Y + V Y G E T+ NL+P
Sbjct: 679 VLGRPKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEV-YHGPELECTVGNLLPGT 737
Query: 1215 KYDFSVQACTSGGC-LHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPPAELNGII 1273
Y F V+A GG +S +TTA PP + P + + V W P I
Sbjct: 738 VYRFRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADI 797
Query: 1274 IRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTITGLEPYT 1333
Y L E +E + E T I L P
Sbjct: 798 SEYRL---------EWGEDEESL-----------------ELIYHGTDTRFEIRDLLPAA 831
Query: 1334 KYEFRVLAVNMAGS-VSSAWVSERTGESAPVFMIPPSVF---PLSSY------SLNISWE 1383
+Y R+ A N AG+ S V +T SAP + V PL +Y L ++WE
Sbjct: 832 QYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWE 891
Query: 1384 KPADNVTRGKVVGYDINM 1401
+P +N +++ Y I++
Sbjct: 892 EPCNN--GSEILAYTIDL 907
Score = 49.3 bits (116), Expect = 1e-04
Identities = 99/454 (21%), Positives = 161/454 (35%), Gaps = 69/454 (15%)
Query: 1043 DVNNLLGCSKTPFQQPPPRGQVQSSSAINLSWSPPDSPNAHWLTYSLLRDGFEIYTTEDQ 1102
DV+ + + P Q P + + W PDS A Y L G + + E
Sbjct: 756 DVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRL-EWGEDEESLELI 814
Query: 1103 YPYSIQYFLDTDLLPYTKYSYYIETTNVHGS-TRSVAVTYKTKPGVPEGNLTLSYIIPIG 1161
Y + F DLLP +Y ++ N G+ S V +T P+ TL +
Sbjct: 815 YHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAPDPVSTLCVLEEEP 874
Query: 1162 SDS--------VTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIWNLVPF 1213
D+ + L W N I Y + G ++ G+ T + +L+P
Sbjct: 875 LDAYPDSPSACLVLNWEEPCNNGSEILAYTIDL-----GDTSITV-GNTTMHVMKDLLPE 928
Query: 1214 AKYDFSVQACTS-GGCLHSLPITVTTAQAPPQRLSPPKMQKISS--TELHVEWSPPAELN 1270
Y +QA G S I T PP PP+++ ++ L ++W
Sbjct: 929 TTYRIRIQAINEIGAGPFSQFIKAKTRPLPPL---PPRLECAAAGPQSLKLKWGD----- 980
Query: 1271 GIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENAL---KPPQTMTTIT 1327
S +T + E V+ +E N+ + + P +
Sbjct: 981 --------------SNSKTHAAEDIVYTLQ--------LEDRNKRFISIYRGPSHTYKVQ 1018
Query: 1328 GLEPYTKYEFRVLAVNMAGSVS-SAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPA 1386
L +T Y FR+ A + AG S + T +S P + P V L S I WE
Sbjct: 1019 RLTEFTCYSFRIQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVP 1078
Query: 1387 DNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITL 1446
+G V Y + +L + S+ K +E ++ + GL+ Y F +
Sbjct: 1079 S--MKGDPVNYILQVLVGRE---------SEYKQVYKGEEATFQISGLQTNTDYRFRVCA 1127
Query: 1447 CNSVGCVTSA---SGAGQTLAAAPAQLRPPLVKG 1477
C C+ ++ SGA AA Q ++ G
Sbjct: 1128 CRR--CLDTSQELSGAFSPSAAFVLQRSEVMLTG 1159
Score = 42.4 bits (98), Expect = 0.012
Identities = 92/481 (19%), Positives = 168/481 (34%), Gaps = 51/481 (10%)
Query: 1035 CVPSASHLDVNNLLGC---SKTPFQQPPPR--GQVQSSSAINLSWSPPDSPNAHWLT-YS 1088
C+ + H + L S P Q PPR G+ + ++L W P S + ++ YS
Sbjct: 649 CISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGRPKHKE-VHLEWDVPASESGCEVSEYS 707
Query: 1089 LLRDGFEIYTTEDQYPYSIQYFLDTDLLPYTKYSYYIETTNVHGSTRSVAVTYKTKPGVP 1148
+ E +E + ++ + +LLP T Y + + N G V+ T P
Sbjct: 708 VEMTEPEDVASEVYHGPELECTVG-NLLPGTVYRFRVRALNDGGYGPYSDVSEITTAAGP 766
Query: 1149 EGNLTLSYIIPIGSDSVTLTWTTLSNQSGPIEKYILSCAPLAGGQPCVSYEGHETSATIW 1208
G I V + W + + I +Y L + Y G +T I
Sbjct: 767 PGQCKAPCISCTPDGCVLVGWESPDSSGADISEYRLEWGEDEESLELI-YHGTDTRFEIR 825
Query: 1209 NLVPFAKYDFSVQACTSGGC--LHSLPITVTTAQAPPQRLSPPKMQKISSTELHVEWSPP 1266
+L+P A+Y +QA G L + T A AP P E ++ P
Sbjct: 826 DLLPAAQYCCRLQAFNQAGAGPYSELVLCQTPASAP-----DPVSTLCVLEEEPLDAYPD 880
Query: 1267 AELNGIIIRYELYMRRLRSTKETTSEESRVFQSSGWLSPHSFVESANENALKPPQTMTTI 1326
+ +++ +E E + S + + ++ + + TM +
Sbjct: 881 SPSACLVLNWE----------EPCNNGSEILAYT--------IDLGDTSITVGNTTMHVM 922
Query: 1327 TGLEPYTKYEFRVLAVNMAGS-VSSAWVSERTGESAPVFMIPPSV--FPLSSYSLNISWE 1383
L P T Y R+ A+N G+ S ++ +T P+ +PP + SL + W
Sbjct: 923 KDLLPETTYRIRIQAINEIGAGPFSQFIKAKT---RPLPPLPPRLECAAAGPQSLKLKWG 979
Query: 1384 KPADNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFT 1443
+ + Y + + + + + +Y V+ L + Y F
Sbjct: 980 DSNSKTHAAEDIVYTLQLEDRN----------KRFISIYRGPSHTYKVQRLTEFTCYSFR 1029
Query: 1444 ITLCNSVG-CVTSASGAGQTLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPIYQL 1502
I + G S + T + P ++ P V + + + W + G Y L
Sbjct: 1030 IQAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYIL 1089
Query: 1503 E 1503
+
Sbjct: 1090 Q 1090
Score = 40.4 bits (93), Expect = 0.046
Identities = 52/186 (27%), Positives = 73/186 (39%), Gaps = 23/186 (12%)
Query: 1329 LEPYTKYEFRVLAV--NMAGSVSSAWVSERTGESAPVFMIPPSVFPLSSYSLNISWEKPA 1386
L P T Y RV A+ ++ GS S VS T AP PP + S SL + W+ P
Sbjct: 345 LRPATDYHVRVYAMYNSVKGSCSEP-VSFTTHSCAPECPFPPKLAHRSKSSLTLQWKAPI 403
Query: 1387 DNVTRGKVVGYDINMLSEQSPQQSIPMAFSQLLHTAKSQELSYTVEGLKPYRIYEFTITL 1446
DN K+ Y + ++ + S F Q ++ + L P Y F +
Sbjct: 404 DN--GSKITNYLLEW--DEGKRNS---GFRQCFFGSQKH---CKLTKLCPAMGYTFRLAA 453
Query: 1447 CNSVGCVTSASGAGQ-----TLAAAPAQLRPPLVKGINSTTIHLKWFPPEELNGPSPI-Y 1500
N +G SG Q TL P P + T + L+W PE + I Y
Sbjct: 454 RNDIG----TSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVITY 509
Query: 1501 QLERRE 1506
LE +E
Sbjct: 510 TLEIQE 515
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 227,842,012
Number of Sequences: 37866
Number of extensions: 11564582
Number of successful extensions: 48919
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 334
Number of HSP's that attempted gapping in prelim test: 28855
Number of HSP's gapped (non-prelim): 9328
length of query: 5202
length of database: 18,247,518
effective HSP length: 124
effective length of query: 5078
effective length of database: 13,552,134
effective search space: 68817736452
effective search space used: 68817736452
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.