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Search of human proteins with 218505793
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo
sapiens]
(1677 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 3350 0.0
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 3344 0.0
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 2966 0.0
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 2904 0.0
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 2902 0.0
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 2897 0.0
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 2895 0.0
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 2886 0.0
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 2845 0.0
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 2833 0.0
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 2795 0.0
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 1600 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 343 1e-93
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 324 5e-88
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 314 4e-85
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 293 1e-78
gi|16933557 dachsous 1 precursor [Homo sapiens] 291 3e-78
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 290 6e-78
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 281 3e-75
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 278 2e-74
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 268 3e-71
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 266 1e-70
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 221 6e-57
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 206 1e-52
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 206 1e-52
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 198 3e-50
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 198 3e-50
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 198 3e-50
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 195 4e-49
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 195 4e-49
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 3350 bits (8687), Expect = 0.0
Identities = 1677/1677 (100%), Positives = 1677/1677 (100%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1441 PPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEWARKRM 1500
PPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEWARKRM
Sbjct: 1441 PPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEWARKRM 1500
Query: 1501 IKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRACLTDNL 1560
IKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRACLTDNL
Sbjct: 1501 IKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRACLTDNL 1560
Query: 1561 KVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPVGTDNT 1620
KVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPVGTDNT
Sbjct: 1561 KVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPVGTDNT 1620
Query: 1621 AVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMTKL 1677
AVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMTKL
Sbjct: 1621 AVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMTKL 1677
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 3344 bits (8671), Expect = 0.0
Identities = 1677/1682 (99%), Positives = 1677/1682 (99%), Gaps = 5/1682 (0%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 416 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 475
DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ
Sbjct: 421 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 480
Query: 476 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD
Sbjct: 481 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540
Query: 536 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 595
ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR
Sbjct: 541 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600
Query: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG
Sbjct: 601 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 716 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 775
VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV
Sbjct: 721 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780
Query: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 835
KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG
Sbjct: 781 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 840
Query: 836 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 895
TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL
Sbjct: 841 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 900
Query: 896 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 955
VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP
Sbjct: 901 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 960
Query: 956 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1015
PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV
Sbjct: 961 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1020
Query: 1016 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1075
MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN
Sbjct: 1021 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1080
Query: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140
Query: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1195
DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200
Query: 1196 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1255
VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV
Sbjct: 1201 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1260
Query: 1256 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1315
PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP
Sbjct: 1261 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1320
Query: 1316 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1375
QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG
Sbjct: 1321 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1380
Query: 1376 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1435
ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP
Sbjct: 1381 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1440
Query: 1436 PPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEW 1495
PPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEW
Sbjct: 1441 PPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEEEYEEEEW 1500
Query: 1496 ARKRMIKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRAC 1555
ARKRMIKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRAC
Sbjct: 1501 ARKRMIKLVVDREYETSSTGEDSAPECQRNRLHHPSIHSNINGNIYIAQNGSVVRTRRAC 1560
Query: 1556 LTDNLKVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPV 1615
LTDNLKVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPV
Sbjct: 1561 LTDNLKVASPVRLGGPFKKLDKLAVTHEENVPLNTLSKGPFSTEKMNARPTLVTFAPCPV 1620
Query: 1616 GTDNTAVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMT 1675
GTDNTAVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMT
Sbjct: 1621 GTDNTAVKPLRNRLKSTVEQESMIDSKNIKEALEFHSDHTQSDDEELWMGPWNNLHIPMT 1680
Query: 1676 KL 1677
KL
Sbjct: 1681 KL 1682
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 2966 bits (7689), Expect = 0.0
Identities = 1497/1518 (98%), Positives = 1500/1518 (98%), Gaps = 12/1518 (0%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 416 DSLNLTSPLRIVALDKDIED-------TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 468
DSLNLTSPLRIVALDKDIED TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP
Sbjct: 421 DSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQP 480
Query: 469 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV
Sbjct: 481 VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
Query: 529 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 588
IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN
Sbjct: 541 IQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADN 600
Query: 589 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 648
APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI
Sbjct: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI 660
Query: 649 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 708
TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT
Sbjct: 661 TYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVT 720
Query: 709 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 768
DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN
Sbjct: 721 DVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN 780
Query: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV
Sbjct: 781 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 840
Query: 829 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 888
EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ
Sbjct: 841 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 900
Query: 889 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 948
EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV
Sbjct: 901 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
Query: 949 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA
Sbjct: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1020
Query: 1009 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1068
FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV
Sbjct: 1021 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1080
Query: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA
Sbjct: 1081 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1140
Query: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI
Sbjct: 1141 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1200
Query: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1248
KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM
Sbjct: 1201 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1260
Query: 1249 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1308
QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL
Sbjct: 1261 QVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDL 1320
Query: 1309 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1368
TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE
Sbjct: 1321 TVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGE 1380
Query: 1369 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1428
SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA
Sbjct: 1381 SLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPA 1440
Query: 1429 PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE 1488
PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE
Sbjct: 1441 PAPVAAPPPPPPPPPGAHLYEELGDSSMHKYEMPQYGSRRRLLPPAGQEEYGEVVGEAEE 1500
Query: 1489 EYEEEEWARKRMIKLVVD 1506
EYEEEE K++ K V+
Sbjct: 1501 EYEEEEEEPKKIKKPKVE 1518
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 2904 bits (7527), Expect = 0.0
Identities = 1458/1458 (100%), Positives = 1458/1458 (100%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1441 PPPGAHLYEELGDSSMHK 1458
PPPGAHLYEELGDSSMHK
Sbjct: 1441 PPPGAHLYEELGDSSMHK 1458
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 2902 bits (7522), Expect = 0.0
Identities = 1457/1457 (100%), Positives = 1457/1457 (100%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1441 PPPGAHLYEELGDSSMH 1457
PPPGAHLYEELGDSSMH
Sbjct: 1441 PPPGAHLYEELGDSSMH 1457
Score = 31.2 bits (69), Expect = 8.8
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
P P +P P P PPPPP PPPP A
Sbjct: 1807 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1835
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 2897 bits (7510), Expect = 0.0
Identities = 1455/1456 (99%), Positives = 1456/1456 (100%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
Query: 1441 PPPGAHLYEELGDSSM 1456
PPPGAHLYEELGDSS+
Sbjct: 1441 PPPGAHLYEELGDSSI 1456
Score = 31.2 bits (69), Expect = 8.8
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
P P +P P P PPPPP PPPP A
Sbjct: 1805 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1833
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 2895 bits (7506), Expect = 0.0
Identities = 1457/1462 (99%), Positives = 1457/1462 (99%), Gaps = 5/1462 (0%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDD-----CKLARGGPPATIVAIDEESRNGTI 55
MFRQFYLWTCLASGIILGSLFEICLGQYDDD CKLARGGPPATIVAIDEESRNGTI
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTI 60
Query: 56 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 115
LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV
Sbjct: 61 LVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIV 120
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG
Sbjct: 121 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 180
Query: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 235
ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN
Sbjct: 181 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQAN 240
Query: 236 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL
Sbjct: 241 DRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 300
Query: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 355
NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR
Sbjct: 301 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNR 360
Query: 356 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 415
DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS
Sbjct: 361 DFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATIS 420
Query: 416 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 475
DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ
Sbjct: 421 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 480
Query: 476 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD
Sbjct: 481 TYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540
Query: 536 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 595
ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR
Sbjct: 541 ADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 600
Query: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG
Sbjct: 601 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 660
Query: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP
Sbjct: 661 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 720
Query: 716 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 775
VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV
Sbjct: 721 VFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAV 780
Query: 776 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 835
KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG
Sbjct: 781 KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAG 840
Query: 836 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 895
TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL
Sbjct: 841 TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 900
Query: 896 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 955
VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP
Sbjct: 901 VEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 960
Query: 956 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1015
PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV
Sbjct: 961 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV 1020
Query: 1016 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1075
MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN
Sbjct: 1021 MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1080
Query: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ
Sbjct: 1081 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1140
Query: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1195
DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF
Sbjct: 1141 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1200
Query: 1196 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1255
VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV
Sbjct: 1201 VVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNV 1260
Query: 1256 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1315
PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP
Sbjct: 1261 PPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDP 1320
Query: 1316 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1375
QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG
Sbjct: 1321 QTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEG 1380
Query: 1376 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1435
ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP
Sbjct: 1381 ALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAP 1440
Query: 1436 PPPPPPPPGAHLYEELGDSSMH 1457
PPPPPPPPGAHLYEELGDSSMH
Sbjct: 1441 PPPPPPPPGAHLYEELGDSSMH 1462
Score = 31.2 bits (69), Expect = 8.8
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
P P +P P P PPPPP PPPP A
Sbjct: 1812 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1840
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 2886 bits (7481), Expect = 0.0
Identities = 1452/1456 (99%), Positives = 1453/1456 (99%), Gaps = 3/1456 (0%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
Query: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
Query: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Query: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
Query: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
Query: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1381 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1437
Query: 1441 PPPGAHLYEELGDSSM 1456
PPPGAHLYEELGDSS+
Sbjct: 1438 PPPGAHLYEELGDSSI 1453
Score = 31.2 bits (69), Expect = 8.8
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
P P +P P P PPPPP PPPP A
Sbjct: 1802 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1830
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 2845 bits (7374), Expect = 0.0
Identities = 1435/1457 (98%), Positives = 1435/1457 (98%), Gaps = 22/1457 (1%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
Query: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
Query: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
Query: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
Query: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
Query: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
Query: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1359 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1418
Query: 1441 PPPGAHLYEELGDSSMH 1457
PPPGAHLYEELGDSSMH
Sbjct: 1419 PPPGAHLYEELGDSSMH 1435
Score = 31.2 bits (69), Expect = 8.8
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
P P +P P P PPPPP PPPP A
Sbjct: 1785 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1813
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 2833 bits (7345), Expect = 0.0
Identities = 1432/1457 (98%), Positives = 1432/1457 (98%), Gaps = 25/1457 (1%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDD GTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDD----------------------GTILVDNM 38
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 39 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 98
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 99 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 158
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 159 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 218
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 219 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 278
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 279 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 338
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 339 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 398
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 399 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 458
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 459 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 518
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 519 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 578
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 579 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 638
Query: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 639 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 698
Query: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 758
Query: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 759 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 818
Query: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 819 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 878
Query: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 879 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 938
Query: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 939 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 998
Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 999 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1058
Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1059 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1118
Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1119 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1178
Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1179 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1238
Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1239 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1298
Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1299 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1358
Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1359 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1415
Query: 1441 PPPGAHLYEELGDSSMH 1457
PPPGAHLYEELGDSSMH
Sbjct: 1416 PPPGAHLYEELGDSSMH 1432
Score = 31.2 bits (69), Expect = 8.8
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
P P +P P P PPPPP PPPP A
Sbjct: 1782 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1810
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 2795 bits (7245), Expect = 0.0
Identities = 1415/1456 (97%), Positives = 1416/1456 (97%), Gaps = 40/1456 (2%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDP DRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDP-------------------------------------DRAQN 203
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 263
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 264 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 323
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 324 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 383
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 384 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 443
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 444 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 503
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT
Sbjct: 504 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 563
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 660
VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV
Sbjct: 564 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRV 623
Query: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 720
FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY
Sbjct: 624 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPY 683
Query: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 780
LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE
Sbjct: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNRE 743
Query: 781 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ
Sbjct: 744 VRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 803
Query: 841 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 900
IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD
Sbjct: 804 IEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
Query: 901 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 960
IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA
Sbjct: 864 IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPA 923
Query: 961 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA
Sbjct: 924 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 983
Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1080
TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF
Sbjct: 984 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF 1043
Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH
Sbjct: 1044 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1103
Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY
Sbjct: 1104 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1163
Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV
Sbjct: 1164 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1223
Query: 1261 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1320
EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA
Sbjct: 1224 EKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRA 1283
Query: 1321 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1380
IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL
Sbjct: 1284 IDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLAL 1343
Query: 1381 AFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1440
AFIIILCCIPAILVVLVSYRQ RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP
Sbjct: 1344 AFIIILCCIPAILVVLVSYRQ---RQAECTKTARIQAALPAAKPAVPAPAPVAAPPPPPP 1400
Query: 1441 PPPGAHLYEELGDSSM 1456
PPPGAHLYEELGDSS+
Sbjct: 1401 PPPGAHLYEELGDSSI 1416
Score = 31.2 bits (69), Expect = 8.8
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
P P +P P P PPPPP PPPP A
Sbjct: 1765 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1793
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
Length = 1886
Score = 1600 bits (4142), Expect = 0.0
Identities = 873/1184 (73%), Positives = 947/1184 (79%), Gaps = 78/1184 (6%)
Query: 344 TAELSLLEPVNRDFHQKFDLVIKAE---QDNGHPLPAFAGLHIEILDENNQSPYFT---- 396
T + L + +N + ++ ++I+A Q+ L +++LD ++ P F
Sbjct: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
Query: 397 MPSYQG---YILESAPVGATISDSLN---LTSPLRIVALDKDIEDTKDPELHLFL----- 445
+P+ + ++A + LN +T P++ + D++I+ D L+
Sbjct: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 446 -NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDA 502
DY F + T L+LL+PV+R+ Q + I A P ++I+++D
Sbjct: 331 PEDYPRFFHMHPR--TAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDE 388
Query: 503 NDNTPTFPEISYDVYVYTDMRPGDSV---------IQLTAVDAD-EGSNGEITYEILVGA 552
N+ +P F SY Y+ G ++ +++ A+D D E + + L
Sbjct: 389 NNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 448
Query: 553 QGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNN 610
F + +T T +T+ V+ +TY ++ A D +E V I+V+ N+
Sbjct: 449 TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDAND 504
Query: 611 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETT 667
+P FP++ Y + + MR G ++ L A D + S ITY I G Q F +++TT
Sbjct: 505 NTPT-FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT 562
Query: 668 G----------------------------------ILTLGKALDRESTDRYILIITASDG 693
G ILTLGKALDRESTDRYILIITASDG
Sbjct: 563 GLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDG 622
Query: 694 RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 753
RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH
Sbjct: 623 RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVH 682
Query: 754 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 813
YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID
Sbjct: 683 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 742
Query: 814 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 873
DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE
Sbjct: 743 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 802
Query: 874 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 933
LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG
Sbjct: 803 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKG 862
Query: 934 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993
MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN
Sbjct: 863 MVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 922
Query: 994 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1053
LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT
Sbjct: 923 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 982
Query: 1054 MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1113
MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE
Sbjct: 983 MVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE 1042
Query: 1114 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT
Sbjct: 1043 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1102
Query: 1174 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS
Sbjct: 1103 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1162
Query: 1234 GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR 1293
GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR
Sbjct: 1163 GKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARR 1222
Query: 1294 HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE 1353
HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE
Sbjct: 1223 HGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILE 1282
Query: 1354 IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTA 1413
IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTA
Sbjct: 1283 IRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTA 1342
Query: 1414 RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMH 1457
RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMH
Sbjct: 1343 RIQAALPAAKPAVPAPAPVAAPPPPPPPPPGAHLYEELGDSSMH 1386
Score = 1263 bits (3268), Expect = 0.0
Identities = 726/1134 (64%), Positives = 804/1134 (70%), Gaps = 87/1134 (7%)
Query: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM
Sbjct: 1 MFRQFYLWTCLASGIILGSLFEICLGQYDDDCKLARGGPPATIVAIDEESRNGTILVDNM 60
Query: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC
Sbjct: 61 LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQC 120
Query: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID
Sbjct: 121 INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDID 180
Query: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN
Sbjct: 181 DGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQN 240
Query: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV
Sbjct: 241 LNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIV 300
Query: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK
Sbjct: 301 TPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK 360
Query: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL
Sbjct: 361 FDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS
Sbjct: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
Query: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS
Sbjct: 481 ITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI-- 598
NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER I
Sbjct: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILT 600
Query: 599 -----------------------------CTVYIEVLPPNNQSPPRFPQLMYSLEISEAM 629
TV I V N+ +P P L +L + E
Sbjct: 601 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE- 659
Query: 630 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 686
A + ++ATD + + Y++ G+ +F ++ I T K L+RE D Y L
Sbjct: 660 EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNREVRDYYEL 716
Query: 687 IITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPD 745
++ A+DG ST T+ I V D++DN+PVF L A + Q++A D D
Sbjct: 717 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 776
Query: 746 AGINGQVHYSLGNFNNLFRI-TSNGSIYTAVKLNREVRDYYE----LVVVATD--GAVHP 798
G N + F + G + L+ E E +V A D G + P
Sbjct: 777 LGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 836
Query: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD----LGANVSY 854
+T+T+ +K D++D PVF+ Y +V + GT I + A+D D + V Y
Sbjct: 837 GIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRY 894
Query: 855 R---IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT 911
R ++ P F + +G + +L+ E +V AFD + AT
Sbjct: 895 RVDDVQFPYPASIFEVEEDSGRVITRVNLNEE----PTTIFKLVVVAFDDGEPVMSSSAT 950
Query: 912 VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 971
V ++V + P + V+ A KGT + + A A + S V +D
Sbjct: 951 VKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-AINQSIVYSIVSGNEEDT- 1008
Query: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM------SSSATVKIL 1025
F + +G + L+ E T + L V A D E V+ S S T K+
Sbjct: 1009 -------FGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTAKVY 1060
Query: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDT 1079
+ EI Q+E PPV + K + GV A + S++ V ++DT
Sbjct: 1061 I----EI----QDENNHPPVFQ--KKFYIGGVSEDARMFTSVLR--VKATDKDT 1102
Score = 31.2 bits (69), Expect = 8.8
Identities = 15/30 (50%), Positives = 16/30 (53%), Gaps = 5/30 (16%)
Query: 1420 PAAKPAVPAPAPVAAPPPPP----PPPPGA 1445
P P +P P P PPPPP PPPP A
Sbjct: 1736 PPTPPLLP-PFPTPLPPPPPSIPCPPPPSA 1764
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 343 bits (879), Expect = 1e-93
Identities = 319/1192 (26%), Positives = 533/1192 (44%), Gaps = 135/1192 (11%)
Query: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATV 156
T +LDR+ ++ +V V I K EV I ++D NDN P F + TV
Sbjct: 1692 TAAILDREQGACLY--LVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTV 1749
Query: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 216
E G+ I A D D+G N + Y I DD D +G+++
Sbjct: 1750 EENIGDGSKIM-----QLTAMDADEGANALVTYTIISGADDSFRIDPE------SGDLIA 1798
Query: 217 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
+RL+ E +++Y ++++A+D Q+ + R + + V D +D P F
Sbjct: 1799 TRRLDRERRSKYSLLVRADDGLQSSDMR------INITVSDVNDHTPKF----------- 1841
Query: 277 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
RP+ Y IPE P L I+ A D D + I Y + +D
Sbjct: 1842 SRPV-YSFDIPEDTIPGSLVAAIL-----ATDDDSGVNGE-----ITYIV---NEDDEDG 1887
Query: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
F ++P T +L ++ + Q + L ++AE G ++ ILD N+ P F+
Sbjct: 1888 IFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTI--RVYFNILDVNDNPPIFS 1945
Query: 397 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFL--NDYTSVFTV 454
+ SY ++E+ PVG+T+ N+T D +D + +L + D FTV
Sbjct: 1946 LNSYSTSLMENLPVGSTVL-VFNVT----------DADDGINSQLTYSIASGDSLGQFTV 1994
Query: 455 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE-----SEPVIVNIQVMDANDNTPTF 509
+ G+ L +L+ +DRE Q Y + D Q + V+I ++D NDN PTF
Sbjct: 1995 DKNGV---LKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTF 2051
Query: 510 --PEISYDVYVYTDMRPGDSVI-QLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 566
P+++Y + P D+V+ + A D D G N I Y +L F I G +
Sbjct: 2052 LSPKLTY----IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGEVR 2107
Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
+ ++ Y LTV A D P+ ++ V + + NN P F Q +Y +EI+
Sbjct: 2108 LTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNN---PIFAQALYKVEIN 2164
Query: 627 EAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDR 683
E G ++ + A D + + Y I NG+ + F + TG +T+ K LDRE T
Sbjct: 2165 ENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPT 2224
Query: 684 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFD--PY---LPRNLSVVEEEANAFVG 737
Y L + A+D G T T+TV+IV+ D+ND PVF+ PY +P NL + +
Sbjct: 2225 YHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT----IL 2280
Query: 738 QVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGA 795
QV A D D G N ++ Y L GN +N F ++++G + L+RE ++ + L++ ATD
Sbjct: 2281 QVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSG 2340
Query: 796 VHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 855
T T+ + V D++DN P F + Y + E+ P GT +L + A D D N R
Sbjct: 2341 SPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIR 2400
Query: 856 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT-VTV 914
I + F ++P TG++ LD E + + T +V D P +T V V
Sbjct: 2401 IIGGNSQ--FTINPSTGQIITSALLDRET----KDNYTLVVVCSDAGSPEPLSSSTSVLV 2454
Query: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
V D+ND PP F Y + + G+ + V DAD P S + Y +
Sbjct: 2455 TVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIG--PNSELHYSLSGRN--- 2509
Query: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPR 1034
+ F ++ G ++ LN F + V D G + S TV + ++ + P+
Sbjct: 2510 -SEKFHIDPLRGAIMAAGPLNGASEVTFSVHVK--DGGSFPKTDSTTVTVRFVNKADFPK 2566
Query: 1035 FTQEEY-----RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVI 1089
+E PVS L T + ++ + + Y I SGN +TF I+ +TG +
Sbjct: 2567 VRAKEQTFMFPENQPVSSLVTT-----ITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQV 2621
Query: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149
++ PLD+E YV+ ++A + P S+ K+ I + D N++ P+F++ +
Sbjct: 2622 SISQPLDFEKIQKYVVWIEA-------RDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPF 2674
Query: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209
I + E+ +L V A DKD+G + Y ++ + + F + TG I++
Sbjct: 2675 ISEILENLSP-RKILTVSAMDKDSGPNGQLDYEIVNGNM---ENSFSINHATGEIRSVRP 2730
Query: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD-----MQVIVSNVP 1256
+ S++ + ++D S V+++++++ D Q+ ++VP
Sbjct: 2731 LDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNAPRFSQIFSAHVP 2782
Score = 331 bits (849), Expect = 3e-90
Identities = 298/1109 (26%), Positives = 500/1109 (45%), Gaps = 88/1109 (7%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
I V D ND+ P F + Y ++E P G+ + +G S ATD D G N + Y I
Sbjct: 463 IFVNDINDHPPVFSQQVYRVNLSEEAPPGSYV-SGIS----ATDGDSGLNANLRYSIVSG 517
Query: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
+ + L+ TG+ L+ E ++ + I A D+ + + + L V
Sbjct: 518 NGLGWFHISEHSGLVTTGS---SGGLDRELASQIVLNISARDQGVH---PKVSYAQLVVT 571
Query: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
+LD +D P+F +P Y ++ E P ++ ++A D D
Sbjct: 572 LLDVNDEKPVF-----------SQPEGYDVSVVE-NAPTGTELLM----LRATDGDLG-- 613
Query: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
D + +S+ E R F + P + LS + ++R+ + L++ A P
Sbjct: 614 ---DNGTVRFSLQEA--ETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPP 668
Query: 375 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
+ A +++ +LD N+ SP F Y +I E+ P G+ I+ + A D D+
Sbjct: 669 QSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITT---------VSATDPDLG 719
Query: 435 DTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEP 492
+ + D + Q+G+ ++ +DREE+ Y I A DG +Q
Sbjct: 720 TNGTVKYSISAGDRSRFQVNAQSGV---ISTRMALDREEKTAYQLQIVATDGGNLQSPNQ 776
Query: 493 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
IV I V+D DN P F +++Y V+ ++ G V ++A D SN I+Y I G
Sbjct: 777 AIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSN--ISYLITTGD 834
Query: 553 Q-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQ 611
Q G F IN+ TG +T A ++ Y L V A+ + +I + N
Sbjct: 835 QKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGDTMVNITVKDL------ND 888
Query: 612 SPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTG 668
+ P F Q + S+ + E + G + +A D + + Y+++ +P+ +F ++E G
Sbjct: 889 NSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNG 947
Query: 669 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 728
++L LD + I I+ + G P +S+ + + V DVNDN+PVFD
Sbjct: 948 TISLLGPLDVHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSE 1007
Query: 729 EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYE 786
E N+ +V+A+D D+G NG++ Y++ GN + F I +G +Y +L+RE++D Y
Sbjct: 1008 SEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYV 1067
Query: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
L+VVA+D AV P +T+ + + + D++DN P+F ++ YT EE AG+ + ++ A D
Sbjct: 1068 LMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDK 1127
Query: 847 DLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
D G N R V+ F LH +GE++ D E+ + + F +P
Sbjct: 1128 DFGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIP 1187
Query: 907 PGI---ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPAS 961
+ ATV V +KD+ND P F K Y+ ++ A T + V A D D GL
Sbjct: 1188 QPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHY 1247
Query: 962 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 1021
+ ++ Q F ++ SG+V L+ E T + LV+ A D G ++S+ T
Sbjct: 1248 SIIKGNEERQ-------FAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCT 1300
Query: 1022 VKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEE 1077
+ I +L + + V E G +V ++A + N + YSI N
Sbjct: 1301 LNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNH 1360
Query: 1078 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
TF I+ TG I++ LD+ET++ Y L + A + P +S+T V I ++D
Sbjct: 1361 GTFSISPNTGSIFLAKKLDFETQSLYKLNITA-------KDQGRPPRSSTMSVVIHVRDF 1413
Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
N++PP F + E+ + TSV+ V A D D ++Y II + G F +
Sbjct: 1414 NDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSY-TIIQQMPRGNH-FTI 1471
Query: 1198 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
+ G I T + F+ V A D
Sbjct: 1472 DEVKGTIYTNAEIDREFANLFELTVKAND 1500
Score = 298 bits (764), Expect = 2e-80
Identities = 309/1151 (26%), Positives = 507/1151 (44%), Gaps = 143/1151 (12%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
EVR++VRD NDN+P F S T E + G + + ATD D G NG
Sbjct: 120 EVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVIL-----DTATDSDIGSNGVDHRSY 174
Query: 192 QYNPDDPTSNDTFEIPLMLTG-----NIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
+ + +I L +G ++V + L+ E +Y ++++ D+ + +R
Sbjct: 175 RIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGE---PKRR 231
Query: 247 TTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQA 306
+ V V D +D P+F YQA +PE + ++ + +Q
Sbjct: 232 GYLQVNVTVQDINDNPPVF------------GSSHYQAGVPE-------DAVVGSSVLQV 272
Query: 307 IDQDRNIQPPSDRPGILYSIL-VGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
D + +D I Y + GTP F M P T +++ EP++ + +++ L +
Sbjct: 273 AAADADEGTNAD---IRYRLQDEGTP------FQMDPETGLITVREPLDFEARRQYSLTV 323
Query: 366 KAEQDNGHP-LPAFAGLHIEILDENNQSP-----YFTMPSYQGYILESAPVGATI----- 414
+A D G P L A I++LD N+ P YF S + E+A VG +
Sbjct: 324 QA-MDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTV 382
Query: 415 ----SDSLNLTSPLRIVALDK----DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
S + N ++I+ ++ +++ +K P L L + +
Sbjct: 383 TDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSL-------------------IKVA 423
Query: 467 QPVDREEQQTYTFSITAFDGV---------QESEPVIVNIQVMDANDNTPTFPEISYDVY 517
+DRE +Y +++ D S + I V D ND+ P F + Y V
Sbjct: 424 SALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVN 483
Query: 518 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITI--APGVEMI 574
+ + PG V ++A D D G N + Y I+ G G F I++ +GL+T + G++
Sbjct: 484 LSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE 543
Query: 575 VGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAV 634
+ L + A D + S + + +L N++ P Y + + E G
Sbjct: 544 LASQIVLNISARDQG--VHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTE 601
Query: 635 LLNLQATDRE-GD--SITYAIENGD-PQRVFNLSETTGILTLGKALDRESTDRYILIITA 690
LL L+ATD + GD ++ ++++ + +R F L +G L+ +LDRE Y L++ A
Sbjct: 602 LLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLA 661
Query: 691 SD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN 749
+D G P +S A +N+ + D+NDN+PVF P E +++ V ATDPD G N
Sbjct: 662 TDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTN 721
Query: 750 GQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAI 807
G V YS+ G+ + +G I T + L+RE + Y+L +VATDG + + I
Sbjct: 722 GTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTI 781
Query: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 867
VLD DN PVF+ Y+ +V EN+ G + + A +DL +N+SY I + + K FA+
Sbjct: 782 TVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAI 841
Query: 868 HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
+ TG+L+ + D+E + ++ GT+ G V + VKD+ND P F
Sbjct: 842 NQVTGQLTTANVI------DREEQSFYQLKVVASGGTV-TGDTMVNITVKDLNDNSPHFL 894
Query: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
+ I V + G I A+ DP V Y + P ++F + E +G
Sbjct: 895 QAIESVNVVENWQAGHSI--FQAKAVDPDEGVNGMVLYSLKQ----NPKNLFAINEKNGT 948
Query: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVS 1046
+ L+ + +++ ++A D G P +SSS + + V + P F Q Y +S
Sbjct: 949 ISLLGPLDVHAGS-YQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYE-VTLS 1006
Query: 1047 ELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1102
E + + A + N I Y+I GN D FGI G +Y+ LD E +
Sbjct: 1007 ESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFP-DGQLYIKSELDRELQDR 1065
Query: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
YVL VV ++ V S T V + ++D N++ P+F Y E+ R +
Sbjct: 1066 YVLM-------VVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSF 1118
Query: 1163 VLRVKATDKDTGNYSVMAYRL-IIPPIKEGKEGFVVETYTGLIKTAMLFHN---MRR--- 1215
V +V A DKD G + Y ++ P F + +G I F MRR
Sbjct: 1119 VGKVSAVDKDFGPNGEVRYSFEMVQP------DFELHAISGEITNTHQFDRESLMRRRGT 1172
Query: 1216 SYFKFQVIATD 1226
+ F F VIATD
Sbjct: 1173 AVFSFTVIATD 1183
Score = 288 bits (737), Expect = 3e-77
Identities = 286/1073 (26%), Positives = 476/1073 (44%), Gaps = 100/1073 (9%)
Query: 202 DTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDL 261
+TF+I LTG + + + L++E +Y V I+A D ++ L + VLD +D
Sbjct: 2610 NTFQID-QLTGQVSISQPLDFEKIQKYVVWIEARDGGF---PPFSSYEKLDITVLDVNDN 2665
Query: 262 GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG 321
P+F + + + I E +P + I+T + A+D+D D
Sbjct: 2666 APIF------------KEDPFISEILENLSPRK----ILT--VSAMDKDSGPNGQLD--- 2704
Query: 322 ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL 381
Y I+ G E+ F ++ T E+ + P++R+ + L IK+ +
Sbjct: 2705 --YEIVNGNMENS---FSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKV 2759
Query: 382 HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL 441
I ILDEN+ +P F+ + ++ E++P+G T++ R+ D+DI
Sbjct: 2760 MINILDENDNAPRFSQ-IFSAHVPENSPLGYTVT---------RVTTSDEDIGINAISRY 2809
Query: 442 HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMD 501
+ D + FT+ + T + + +P++RE+ Y ++A D + V I V D
Sbjct: 2810 SIM--DASLPFTINPS--TGDIVISRPLNREDTDRYRIRVSAHDSGW-TVSTDVTIFVTD 2864
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INK 560
NDN P F SY + G V Q+ A D DEGSNG++ Y + +Q ++ IN
Sbjct: 2865 INDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFY--FIKSQSEYFRINA 2922
Query: 561 TTGLI--------TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS 612
TTG I G + ++ V ++D P+ + T+ I +N +
Sbjct: 2923 TTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV---DSNDN 2979
Query: 613 PPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTG 668
P+F + Y +++ ++VG L+ + A D + + Y I N + F L TG
Sbjct: 2980 APQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTG 3039
Query: 669 ILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSV 727
+++ +L + + + +TA D G P +S ATV+I VT+ N + P F
Sbjct: 3040 WISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIP 3099
Query: 728 VEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNREVRDY 784
+ V V A D DA +NG + YS+ GN +F I S+ I T K L+ E+
Sbjct: 3100 ESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQK 3159
Query: 785 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 844
+E+ + A DG R ++ + V+D++DNSPVF + Y V EN P+GTT++ + A
Sbjct: 3160 HEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNAT 3219
Query: 845 DVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIY 902
D D G N ++Y ++S + F + P TG ++ LD+E + S V+AF++
Sbjct: 3220 DADSGTNAVIAYTVQSSD-SDLFVIDPNTGVITTQGFLDFET----KQSYHLTVKAFNVP 3274
Query: 903 GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASR 962
ATV + +K N+Y P F ++Y ++ A KGT + V+A D D
Sbjct: 3275 DEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLG--TDGE 3332
Query: 963 VRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA--FDDGEPVMSSSA 1020
V Y + F++ + +G++ L+ E L V+A F
Sbjct: 3333 VHYLIFGNS---RKKGFQINKKTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEV 3389
Query: 1021 TVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN-----QSIVYSIVSGN 1075
TV + VL + P FT Y +SE GT V +SA + Y I SGN
Sbjct: 3390 TVNVTVLDANDPPIFTLNIY-SVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGN 3448
Query: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
E F IN TG I V LD ET Y +L V+ + PS + +A + + ++
Sbjct: 3449 ENGAFSINPQTGQITVTAELDRETLPIY-------NLSVLAVDSGTPSATGSASLLVTLE 3501
Query: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD-TGNYSVMAYRLIIPPIKEGKEG 1194
D N++ P+ G V E+ R T V+ +++TD D N Y L+
Sbjct: 3502 DINDNGPMLTVS--EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLL--STGPATSY 3557
Query: 1195 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
F + T G++ T + + F V+ D +S V ++V++Q D
Sbjct: 3558 FSLST-AGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQND 3609
Score = 283 bits (724), Expect = 1e-75
Identities = 267/925 (28%), Positives = 409/925 (44%), Gaps = 83/925 (8%)
Query: 381 LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD-KDIEDTKDP 439
+ + + D N+ +P F PS E + G + S + +D + +
Sbjct: 121 VRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGN 180
Query: 440 ELHLFLNDYTSVFTVTQTGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEP----- 492
E F D T+ +G +L L+ +DRE Y + D + EP
Sbjct: 181 EAGRFRLD----ITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVED---KGEPKRRGY 233
Query: 493 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
+ VN+ V D NDN P F Y V D G SV+Q+ A DADEG+N +I Y L
Sbjct: 234 LQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYR-LQDE 292
Query: 553 QGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS 612
F ++ TGLIT+ ++ R Y+LTVQA D P+ I++L N+
Sbjct: 293 GTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGVPS--LTGRAEALIQLLDVNDND 350
Query: 613 P----PRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLS 664
P FP + E +VG V+ L TD + +I+ I G+ QR F +
Sbjct: 351 PVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQ 410
Query: 665 ET----TGILTLGKALDRESTDRYILIITASD--GRPDG------TSTATVNIVVTDVND 712
+ ++ + ALDRE Y L ++ SD G P G +S A++ I V D+ND
Sbjct: 411 SSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDIND 470
Query: 713 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL--FRITSNGS 770
+ PVF + R E ++V + ATD D+G+N + YS+ + N L F I+ +
Sbjct: 471 HPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSG 530
Query: 771 IYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-STYTV 826
+ T L+RE+ L + A D VHP+ S L + +LD++D PVF+ Y V
Sbjct: 531 LVTTGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDV 590
Query: 827 LVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV---KHFFALHPFTGELSLLRSLDYE 883
V EN P GT +L + A D DLG N + R E + F L P +G LS + SLD E
Sbjct: 591 SVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDRE 650
Query: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
++A + LV A D+ +A + V + D+ND PVF Y + + G+
Sbjct: 651 ----EQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGS 706
Query: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
ITTV A D D V+Y + S F+V SG + TR+ L+ E T ++
Sbjct: 707 YITTVSATDPDLG--TNGTVKYSIS----AGDRSRFQVNAQSGVISTRMALDREEKTAYQ 760
Query: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA- 1062
L +VA D G + A V I VL + P + V E G VG +SA+
Sbjct: 761 LQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTM 820
Query: 1063 -INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRV 1121
+N +I Y I +G+++ F IN +TG + +D E ++ Y L+V A V
Sbjct: 821 DLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTV------- 873
Query: 1122 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1181
+ V I ++D N++ P F + V E+ + S+ + KA D D G ++ Y
Sbjct: 874 ---TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLY 930
Query: 1182 RLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV- 1240
L P K F + G I ++ ++ +++A+D LS + V
Sbjct: 931 SLKQNP----KNLFAINEKNGTISLLGPL-DVHAGSYQIEILASDMGVPQLSSSVILTVY 985
Query: 1241 --------SVVNQLDMQVIVSNVPP 1257
V +QL +V +S P
Sbjct: 986 VHDVNDNSPVFDQLSYEVTLSESEP 1010
Score = 268 bits (686), Expect = 3e-71
Identities = 283/1042 (27%), Positives = 475/1042 (45%), Gaps = 112/1042 (10%)
Query: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
Y ++ I V D NDN+P FK + + + + E L+P I T A D D GPNGQ++
Sbjct: 2652 YEKLDITVLDVNDNAPIFKEDPFISEILENLSP--RKILTV-----SAMDKDSGPNGQLD 2704
Query: 189 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Y I + ++F I TG I + L+ E + Y + I+++D+ + ++T+
Sbjct: 2705 YEIV----NGNMENSFSIN-HATGEIRSVRPLDREKVSHYVLTIKSSDKG---SPSQSTS 2756
Query: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
+ +++LD +D P F + A +PE +P VT D
Sbjct: 2757 VKVMINILDENDNAPRFSQI-------------FSAHVPE-NSPLGYTVTRVTTS----D 2798
Query: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAE 368
+D I S YSI+ D F ++P T ++ + P+NR+ ++ + + A
Sbjct: 2799 EDIGINAISR-----YSIM-----DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAH 2848
Query: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
D+G + + I + D N+ +P F+ SY E +G+ ++ ++ A
Sbjct: 2849 -DSGWTVST--DVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVT---------QVFA 2896
Query: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTG---ITRYLTLLQPV---DREEQQTYTFSIT 482
D D + + ++ F+ + F + T + + Q V ++F +T
Sbjct: 2897 TDPD--EGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVT 2954
Query: 483 AFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEG 539
+ D + S V I ++D+NDN P F + Y V +++ G +I++TA+D D G
Sbjct: 2955 SSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFG 3014
Query: 540 SNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSI 598
N E+ Y I G F ++ TG I++A + + + + +TV A D P +S
Sbjct: 3015 LNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPP--LSSQ 3072
Query: 599 CTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENG 655
TV+I V N +P F Q S I E+ +G+++ + A DR+ I Y+I +G
Sbjct: 3073 ATVHITVTEENYHTP-EFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSG 3131
Query: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVND 712
+ + +F ++ +TGILTL KALD E ++ + I+A DG G + TVN++ DVND
Sbjct: 3132 NEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVI--DVND 3189
Query: 713 NAPVF--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN- 768
N+PVF D Y P L + V + ATD D+G N + Y++ + ++LF I N
Sbjct: 3190 NSPVFLSDDYFPTVLE--NAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNT 3247
Query: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
G I T L+ E + Y L V A + R S T+ I++ ++ P F + Y +
Sbjct: 3248 GVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEI 3307
Query: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 886
E P GT + ++ A D DLG + V Y I K F ++ TG++ + LD E
Sbjct: 3308 SEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREK-- 3365
Query: 887 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 946
++ S+ L + F TV V V D ND PP+F+ IY ++ GT +T
Sbjct: 3366 EERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVT 3424
Query: 947 TVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
V A D+D +P+ SR Y + F + +G++ L+ E I+ L
Sbjct: 3425 FVSAFDSD--SIPSWSRFSYFIGSGN---ENGAFSINPQTGQITVTAELDRETLPIYNLS 3479
Query: 1006 VVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA--- 1061
V+A D G P + SA++ + + + P T E V E GT+V + +
Sbjct: 3480 VLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGE---VMENKRPGTLVMTLQSTDPD 3536
Query: 1062 -AINQS-IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
NQ Y ++S ++ + GV+ +D E + L VV +
Sbjct: 3537 LPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYL-------SVVTKDS 3589
Query: 1120 RVPSKSNTAKVYIEIQDENNHP 1141
VP S+T V+I + D+N++P
Sbjct: 3590 GVPQMSSTGTVHITVIDQNDNP 3611
Score = 260 bits (665), Expect = 7e-69
Identities = 303/1158 (26%), Positives = 498/1158 (43%), Gaps = 135/1158 (11%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VI 191
V + ++D NDN+P F + Y AT++E T + A+D+D+G NG I Y +I
Sbjct: 1196 VHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRV-----SASDVDEGNNGLIHYSII 1250
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQ-NLNERRTTTTT 250
+ N + + D+ +G + L +L+YE Y ++IQA D LN +T T
Sbjct: 1251 KGNEERQFAIDS------TSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLN----STCT 1300
Query: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
L +D+LD +D P F L + + +R E ++ + T D D
Sbjct: 1301 LNIDILDENDNTPSFPKSTL-----------FVDVLENMRIGELVSSVTAT------DSD 1343
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
D + YSI T + F + P T + L + ++ + + L I A+
Sbjct: 1344 SG-----DNADLYYSI---TGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQ 1395
Query: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
P + + I + D N+ P F I+E+ P+G TS + + A D
Sbjct: 1396 GRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIG---------TSVISVTAHD 1446
Query: 431 KDIEDTKDPELHLFLN-DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
D + + + FT+ + T Y +DRE + ++ A D
Sbjct: 1447 PDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNA--EIDREFANLFELTVKANDQAVP 1504
Query: 490 SEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ-LTAVDADEGSNGE 543
E V I V D NDN P F IS + SV+ + A D DEG+NGE
Sbjct: 1505 IETRRYALKNVTILVTDLNDNVPMF--ISQNALAADPSAVIGSVLTTIMAADPDEGANGE 1562
Query: 544 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
I YEI+ G FI+++ +G + +A + + Y L V A D P + + T+ +
Sbjct: 1563 IEYEIINGDTDTFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTIIL 1621
Query: 604 EVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-------ITYAIENGD 656
+ L P F Q Y + E +G +++++A G ++ E
Sbjct: 1622 QGL-----DGPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKT 1676
Query: 657 PQRVFNLSETTGILTLGKALDRESTDRYILI----ITASDGRPDGTSTATVNIVVTDVND 712
R+F + TGI+ LDRE L+ I S P T A V I + D+ND
Sbjct: 1677 VGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFP-RTQRAEVEITLQDIND 1735
Query: 713 NAPVFDPYLPRNLSVVEEEAN-AFVGQVKATDPDAGINGQVHYS-LGNFNNLFRI-TSNG 769
N PVF P +L+V E + + + Q+ A D D G N V Y+ + ++ FRI +G
Sbjct: 1736 NPPVF-PTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESG 1794
Query: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
+ +L+RE R Y L+V A DG + S + + I V D++D++P F+ Y+ +
Sbjct: 1795 DLIATRRLDRERRSKYSLLVRADDGL---QSSDMRINITVSDVNDHTPKFSRPVYSFDIP 1851
Query: 830 ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 887
E+ G+ + I A D D G N ++Y + + F L+P TG +L R LDYE
Sbjct: 1852 EDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEV--- 1908
Query: 888 QEASITFLVEAFDIYGTMPPGIATVTVI--VKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
+ V A D G T+ V + D+ND PP+FS Y + + G+ +
Sbjct: 1909 -QQYYILTVRAEDGGGQ----FTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTV 1963
Query: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKL 1004
DAD G+ S++ Y + S+ + D V+ + L+ E + + L
Sbjct: 1964 LVFNVTDAD-DGI-NSQLTYSIASGD-----SLGQFTVDKNGVLKVLKALDRESQSFYNL 2016
Query: 1005 VVVAFDDGEPVMS---SSATVKILVLHPGE-IPRFTQEE--YRP--PPVSELATKGTMVG 1056
VV D + S S+A V I++L + P F + Y P P+ + K
Sbjct: 2017 VVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFKAQATD 2076
Query: 1057 VISAAAINQSIVYSIVS--GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1114
S N I Y++++ GN+ F I I G + + G LD E ++Y +L V
Sbjct: 2077 PDSGP--NSYIEYTLLNPLGNK---FSIGTIDGEVRLTGELDREEVSNY-------TLTV 2124
Query: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
V + PS S++ +V + + D N++ P+F + Y ++E+ T +++V A D D G
Sbjct: 2125 VATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEG 2184
Query: 1175 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSG 1234
+ Y ++ + F +++ TG I A + + V ATD +G +
Sbjct: 2185 TNGQVRYGIV---NGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATD---RGSTP 2238
Query: 1235 KADVLVSVVNQLDMQVIV 1252
+ D + LD+ V
Sbjct: 2239 RTDTSTVSIVLLDINDFV 2256
Score = 250 bits (639), Expect = 7e-66
Identities = 288/1091 (26%), Positives = 459/1091 (42%), Gaps = 109/1091 (9%)
Query: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
Y +V + V+D NDN P F Y A V E VG+++ A D D+G N I Y
Sbjct: 233 YLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVL-----QVAAADADEGTNADIRY 287
Query: 190 VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
+Q + P D TG I +R+ L++E + +Y + +QA DR R
Sbjct: 288 RLQ-DEGTPFQMDP------ETGLITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEAL 340
Query: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
+DV D D P+ P ++ + A+
Sbjct: 341 IQLLDVNDND-------------------PVVKFRYFPATSRYASVDENAQVGTVVALLT 381
Query: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMH----PRTAELSLLEPVNRDFHQKFDLVI 365
+ P+ I IL G + R F + P + + + ++R+ ++L +
Sbjct: 382 VTDADSPAANGNISVQILGGNEQ---RHFEVQSSKVPNLSLIKVASALDRERIPSYNLTV 438
Query: 366 KAEQDNGHPLPA-------FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSL 418
+ G P A A L I + D N+ P F+ Y+ + E AP G+ +S
Sbjct: 439 SVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSG-- 496
Query: 419 NLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT 478
I A D D + + + F +++ +DRE
Sbjct: 497 -------ISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIV 549
Query: 479 FSITAFDGVQESEPVI----VNIQVMDANDNTPTF--PEISYDVYVYTDMRPGDSVIQLT 532
+I+A D Q P + + + ++D ND P F PE YDV V + G ++ L
Sbjct: 550 LNISARD--QGVHPKVSYAQLVVTLLDVNDEKPVFSQPE-GYDVSVVENAPTGTELLMLR 606
Query: 533 AVDADEGSNGEITYEILVGAQGD---FIINKTTGLITIAPGVEMIVGRTYALTVQAADNA 589
A D D G NG + + L A+ D F ++ +G ++ ++ Y+L V A D
Sbjct: 607 ATDGDLGDNGTVRFS-LQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLG 665
Query: 590 PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GD 646
P + +S+ + + +L N+ SP +P + Y I E G+ + + ATD +
Sbjct: 666 SPPQ--SSMARINVSLLDINDNSPVFYP-VQYFAHIKENEPGGSYITTVSATDPDLGTNG 722
Query: 647 SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705
++ Y+I GD R F ++ +G+++ ALDRE Y L I A+D G + A V I
Sbjct: 723 TVKYSISAGDRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTI 781
Query: 706 VVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLGNFNNLFR 764
V D DN PVF + + V E A + VG V A+ D N + G+ +F
Sbjct: 782 TVLDTQDNPPVFS-QVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFA 840
Query: 765 ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
I G + TA ++RE + +Y+L VVA+ G V + I V D++DNSP F +
Sbjct: 841 INQVTGQLTTANVIDREEQSFYQLKVVASGGTV---TGDTMVNITVKDLNDNSPHFLQAI 897
Query: 824 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
+V V EN AG +I Q +A D D G N V Y ++ K+ FA++ G +SLL LD
Sbjct: 898 ESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQ-NPKNLFAINEKNGTISLLGPLD 956
Query: 882 YEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVK 941
A S + A D+ +TV V D+ND PVF + Y+ ++
Sbjct: 957 VHA-----GSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPV 1011
Query: 942 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
+ V A D D + Y + + IF G++ + L+ E
Sbjct: 1012 NSRFFKVQASDKDSGA--NGEIAYTIAEGNTGDAFGIF----PDGQLYIKSELDRELQDR 1065
Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA 1060
+ L+VVA D +S++ V +++ + P F Y E G+ VG +SA
Sbjct: 1066 YVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNY-TFYFEEEQRAGSFVGKVSA 1124
Query: 1061 A----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEV 1114
N + YS + F ++ I+G I D R S + R S V
Sbjct: 1125 VDKDFGPNGEVRYSFEM--VQPDFELHAISGEITNTHQFD---RESLMRRRGTAVFSFTV 1179
Query: 1115 VLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
+ + +P + A V++ ++D N++ P F K FY +SE A T VLRV A+D D
Sbjct: 1180 IATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDE 1239
Query: 1174 GNYSVMAYRLI 1184
GN ++ Y +I
Sbjct: 1240 GNNGLIHYSII 1250
Score = 234 bits (598), Expect = 4e-61
Identities = 238/874 (27%), Positives = 378/874 (43%), Gaps = 99/874 (11%)
Query: 81 VDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDR 140
+ + +MD STG ++ P + +++ G + +V I V D
Sbjct: 2806 ISRYSIMDASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTDVTIFVTDI 2865
Query: 141 NDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 200
NDN+P F SYY ELT +G+ + F ATD D+G NGQ+ Y I+ +
Sbjct: 2866 NDNAPRFSRTSYYLDCPELTEIGSKVTQVF-----ATDPDEGSNGQVFYFIKSQSEYFRI 2920
Query: 201 NDTFEIPLMLTGNIVLRKRLNYEDKT--------RYFVIIQANDRAQNLNERRTTTTTLT 252
N T TG I ++ L Y++ T R+ I+ ++DR + + TT+T
Sbjct: 2921 NAT-------TGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGK---PSLISETTVT 2970
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ--AIDQD 310
++++D +D P FL + TP N + T I+ AID D
Sbjct: 2971 INIVDSNDNAPQFLK-------------------SKYFTPVTKNVKVGTKLIRVTAID-D 3010
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
++ S+ + Y I + +++ F + T +S+ + D +Q F + + A+
Sbjct: 3011 KDFGLNSE---VEYFI---SNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDK 3064
Query: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
PL + A +HI + +EN +P F+ I ES +G+ + + A D
Sbjct: 3065 GNPPLSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVR---------TVSARD 3115
Query: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
+D + + + +F + + T LTL + +D E Q + +I+A DG V
Sbjct: 3116 RDAAMNGLIKYSISSGNEEGIFAINSS--TGILTLAKALDYELCQKHEMTISAIDGGWVA 3173
Query: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
+ V + V+D NDN+P F Y V + G +VI L A DAD G+N I Y +
Sbjct: 3174 RTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTV 3233
Query: 549 LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
F+I+ TG+IT ++ ++Y LTV+A + P E R S TV I+ L
Sbjct: 3234 QSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFN--VPDEERCSFATVNIQ-LKG 3290
Query: 609 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSE 665
N+ PRF +Y EISEA G ++ + A+DR+ + Y I ++ F +++
Sbjct: 3291 TNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINK 3350
Query: 666 TTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVNDNAPVFDPYLP 722
TG + + LDRE +R L + A + R TVN+ V D ND P
Sbjct: 3351 KTGQIYVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDAND-----PPIFT 3405
Query: 723 RNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYT 773
N+ V+ +G V A D D+ I +S GN N F I G I
Sbjct: 3406 LNIYSVQISEGVPIGTHVTFVSAFDSDS-IPSWSRFSYFIGSGNENGAFSINPQTGQITV 3464
Query: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
+L+RE Y L V+A D + +L + + DI+DN P+ T S V+ EN
Sbjct: 3465 TAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGPMLTVSEGEVM--ENKR 3522
Query: 834 AGTTILQIEAKDVDLGAN----VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE 889
GT ++ +++ D DL N Y + + +F+L G LS R +D E D
Sbjct: 3523 PGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFY 3581
Query: 890 ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 923
S+ D TV + V D ND P
Sbjct: 3582 LSVV----TKDSGVPQMSSTGTVHITVIDQNDNP 3611
Score = 216 bits (550), Expect = 1e-55
Identities = 244/842 (28%), Positives = 373/842 (44%), Gaps = 76/842 (9%)
Query: 445 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDAND 504
L++ ++F + + Y T +DRE + ++ + P V + V D ND
Sbjct: 74 LSESHALFAINSSTGALYTT--STIDRESLPSDVINLVVLSSAP-TYPTEVRVLVRDLND 130
Query: 505 NTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG--EITYEILVGAQ-GDFIINKT 561
N P FP+ S V D G VI TA D+D GSNG +Y I+ G + G F ++ T
Sbjct: 131 NAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDIT 190
Query: 562 TG--------LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSP 613
+ G++ V Y L V+ D P R V ++ + N +P
Sbjct: 191 LNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDI---NDNP 247
Query: 614 PRFPQLMYSLEISEAMRVGAVLLNLQATDR-EGDSITYAIENGDPQRVFNLSETTGILTL 672
P F Y + E VG+ +L + A D EG + D F + TG++T+
Sbjct: 248 PVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITV 307
Query: 673 GKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEE 730
+ LD E+ +Y L + A D G P T A I + DVNDN PV Y P
Sbjct: 308 REPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASV 367
Query: 731 EANAFVGQVKA----TDPDA-GINGQVHYSL--GNFNNLFRITSN-----GSIYTAVKLN 778
+ NA VG V A TD D+ NG + + GN F + S+ I A L+
Sbjct: 368 DENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALD 427
Query: 779 REVRDYYELVVVATD-------GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 831
RE Y L V +D AV R S +L I V DI+D+ PVF+ Y V + E
Sbjct: 428 RERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEE 487
Query: 832 LPAGTTILQIEAKDVD--LGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEAFPD 887
P G+ + I A D D L AN+ Y I S +F + +G ++ S LD E
Sbjct: 488 APPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDREL--- 544
Query: 888 QEASITFLVEAFDIYGTMPP-GIATVTVIVKDMNDYPPVFSK-RIYKGMVAPDAVKGTPI 945
+ I + A D G P A + V + D+ND PVFS+ Y V +A GT +
Sbjct: 545 -ASQIVLNISARD-QGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTEL 602
Query: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
+ A D D VR+ + + + + F ++ SGR+ T +L+ E + L+
Sbjct: 603 LMLRATDGDLG--DNGTVRFSLQEAETDRRS--FRLDPVSGRLSTISSLDREEQAFYSLL 658
Query: 1006 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAA--- 1061
V+A D G P SS A + + +L + P F +Y + E G+ + +SA
Sbjct: 659 VLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYF-AHIKENEPGGSYITTVSATDPD 717
Query: 1062 -AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
N ++ YSI +G + F +N +GVI LD E +T+Y L++ A NL+
Sbjct: 718 LGTNGTVKYSISAG-DRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATD----GGNLQ 772
Query: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
P N A V I + D ++PPVF + Y V E+ + V V A+ D S ++
Sbjct: 773 SP---NQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLN--SNIS 827
Query: 1181 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Y LI ++G F + TG + TA + +S+++ +V+A+ G ++G V +
Sbjct: 828 Y-LITTGDQKGM--FAINQVTGQLTTANVIDREEQSFYQLKVVAS---GGTVTGDTMVNI 881
Query: 1241 SV 1242
+V
Sbjct: 882 TV 883
Score = 186 bits (471), Expect = 2e-46
Identities = 205/752 (27%), Positives = 325/752 (43%), Gaps = 78/752 (10%)
Query: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP--PAERRNSICTVYIEVLPPNNQSP 613
F IN +TG + ++ + + + +AP P E R V + L N +
Sbjct: 81 FAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVR-----VLVRDL---NDNA 132
Query: 614 PRFPQLMYSLEISEAMRVGAVLLNLQATDRE-----GDSITYAIENGDPQRVFNLSETTG 668
P FP + E G ++ ATD + D +Y I G+ F L T
Sbjct: 133 PVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLN 192
Query: 669 ILTLGK--------ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP 719
G LDRE T +Y L++ D G P VN+ V D+NDN PVF
Sbjct: 193 PSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGS 252
Query: 720 YLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAVK 776
+ V E+A + V QV A D D G N + Y L + F++ G I
Sbjct: 253 --SHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREP 310
Query: 777 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-----FTNSTYTVLVEEN 831
L+ E R Y L V A D V I++LD++DN PV F ++ V+EN
Sbjct: 311 LDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDEN 370
Query: 832 LPAGTTILQIEAKDVDLGA---NVSYRIRSP-EVKHFFALHPFTGELSLLR---SLDYEA 884
GT + + D D A N+S +I E +HF LSL++ +LD E
Sbjct: 371 AQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRER 430
Query: 885 FPDQEASITFLVEAFDIYGTMPPG--------IATVTVIVKDMNDYPPVFSKRIYKGMVA 936
P S V D YG PPG +A++ + V D+ND+PPVFS+++Y+ ++
Sbjct: 431 IP----SYNLTVSVSDNYGA-PPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLS 485
Query: 937 PDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--L 994
+A G+ ++ + A D D GL A+ +RY + F + E SG V T + L
Sbjct: 486 EEAPPGSYVSGISATDGDS-GLNAN-LRYSIVSGN---GLGWFHISEHSGLVTTGSSGGL 540
Query: 995 NEEPTTIFKLVVVAFDDG-EPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT 1053
+ E + L + A D G P +S + V L+ E P F+Q E V E A GT
Sbjct: 541 DRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGT 600
Query: 1054 MVGVISAA----AINQSIVYSIVSGN-EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1108
+ ++ A N ++ +S+ + +F ++ ++G + LD E + Y
Sbjct: 601 ELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFY----- 655
Query: 1109 ADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA 1168
SL V+ +L P +S+ A++ + + D N++ PVF Y + E+ + + V A
Sbjct: 656 --SLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSA 713
Query: 1169 TDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDY 1228
TD D G + Y + + F V +G+I T M ++ ++ Q++ATD
Sbjct: 714 TDPDLGTNGTVKYSISAGD----RSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGG 769
Query: 1229 GKGLSGKADVLVSVVNQLDMQVIVSNVPPTLV 1260
+A V ++V++ D + S V + V
Sbjct: 770 NLQSPNQAIVTITVLDTQDNPPVFSQVAYSFV 801
Score = 172 bits (436), Expect = 2e-42
Identities = 186/645 (28%), Positives = 296/645 (45%), Gaps = 61/645 (9%)
Query: 638 LQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDG 697
L T + TY + + +F ++ +TG L +DRES ++ + P
Sbjct: 60 LVGTIQTRPGFTYRLS--ESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAP-- 115
Query: 698 TSTATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQV---KATDPDAGINGQVH 753
T V ++V D+NDNAPVF DP ++ V +E ++ QV ATD D G NG H
Sbjct: 116 TYPTEVRVLVRDLNDNAPVFPDP----SIVVTFKEDSSSGRQVILDTATDSDIGSNGVDH 171
Query: 754 YSL----GNFNNLFR--ITSNGS-------IYTAVKLNREVRDYYELVVVATDGAVHPRH 800
S GN FR IT N S + + L+REV Y+L+V D R
Sbjct: 172 RSYRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRR 231
Query: 801 STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPE 860
L + + V DI+DN PVF +S Y V E+ G+++LQ+ A D D G N R R +
Sbjct: 232 GYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQD 291
Query: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
F + P TG +++ LD+EA ++ S+T V+A D G A + + D+N
Sbjct: 292 EGTPFQMDPETGLITVREPLDFEA--RRQYSLT--VQAMDRGVPSLTGRAEALIQLLDVN 347
Query: 921 DYPPVFSKRIYK-----GMVAPDAVKGTPITTVYAEDADPPGLPAS-RVRYRVDDVQFPY 974
D PV R + V +A GT + + DAD P + V+ + Q +
Sbjct: 348 DNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHF 407
Query: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD-GEP---VMSSSATVKILVLHPG 1030
+V S + L+ E + L V D+ G P + + ++V LV+
Sbjct: 408 EVQSSKVPNLS-LIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVN 466
Query: 1031 EI----PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGI 1082
+I P F+Q+ YR +SE A G+ V ISA + +N ++ YSIVSGN F I
Sbjct: 467 DINDHPPVFSQQVYR-VNLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHI 525
Query: 1083 NNITGVIYV--NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
+ +G++ +G LD E + VL + A + V K + A++ + + D N+
Sbjct: 526 SEHSGLVTTGSSGGLDRELASQIVLNISA-------RDQGVHPKVSYAQLVVTLLDVNDE 578
Query: 1141 PPVF-QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
PVF Q + Y V E+A T +L ++ATD D G+ + R + + + F ++
Sbjct: 579 KPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTV--RFSLQEAETDRRSFRLDP 636
Query: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVN 1244
+G + T ++++ V+ATD S A + VS+++
Sbjct: 637 VSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLD 681
Score = 169 bits (429), Expect = 2e-41
Identities = 196/756 (25%), Positives = 323/756 (42%), Gaps = 74/756 (9%)
Query: 109 MNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
+N HS +V K I V I + D NDN+P F Y+ V + VGT +
Sbjct: 2946 INRHSFIV-TSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIR 3004
Query: 169 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML---TGNIVLRKRLNYEDK 225
+ D D D G N ++EY I SND L TG I + L +
Sbjct: 3005 VTAID----DKDFGLNSEVEYFI--------SNDNHLGKFKLDNDTGWISVASSLISDLN 3052
Query: 226 TRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAA 285
+F+ + A D+ N ++ T+ + V + + P F + A
Sbjct: 3053 QNFFITVTAKDKG---NPPLSSQATVHITVTEENYHTPEFSQSHM------------SAT 3097
Query: 286 IPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 345
IPE + I+ T + A D+D + I YSI G E F ++ T
Sbjct: 3098 IPE---SHSIGSIVRT--VSARDRDAAMNGL-----IKYSISSGNEEG---IFAINSSTG 3144
Query: 346 ELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYIL 405
L+L + ++ + QK ++ I A + + + ++D N+ SP F Y +L
Sbjct: 3145 ILTLAKALDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVL 3204
Query: 406 ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTL 465
E+AP G T+ + + A D D T + + + +F + T +T
Sbjct: 3205 ENAPSGTTV---------IHLNATDAD-SGTNAVIAYTVQSSDSDLFVIDPN--TGVITT 3252
Query: 466 LQPVDREEQQTYTFSITAFDGVQESEP--VIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
+D E +Q+Y ++ AF+ E VNIQ+ N+ P F Y +
Sbjct: 3253 QGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAP 3312
Query: 524 PGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITIAPGVEMIVGRTYALT 582
G V ++ A D D G++GE+ Y I + + F INK TG I ++ ++ +L
Sbjct: 3313 KGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERVSLK 3372
Query: 583 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 642
V A + TV + VL N+ PP F +YS++ISE + +G + + A D
Sbjct: 3373 VLAKNFGSIRGADIDEVTVNVTVLDAND--PPIFTLNIYSVQISEGVPIGTHVTFVSAFD 3430
Query: 643 REG----DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDG 697
+ +Y I +G+ F+++ TG +T+ LDRE+ Y L + A D G P
Sbjct: 3431 SDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSA 3490
Query: 698 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGIN-GQVHY-- 754
T +A++ + + D+NDN P+ + + + V +++TDPD N G Y
Sbjct: 3491 TGSASLLVTLEDINDNGPMLT--VSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYL 3548
Query: 755 -SLGNFNNLFRITSNGSIYTAVKLNRE-VRDYYELVVVATDGAVHPRHSTLTLAIKVLDI 812
S G + F +++ G + T +++RE + D+Y L VV D V ST T+ I V+D
Sbjct: 3549 LSTGPATSYFSLSTAGVLSTTREIDREQIADFY-LSVVTKDSGVPQMSSTGTVHITVIDQ 3607
Query: 813 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
+DN V NL G + ++ +D D+
Sbjct: 3608 NDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDV 3643
Score = 153 bits (387), Expect = 1e-36
Identities = 184/709 (25%), Positives = 296/709 (41%), Gaps = 90/709 (12%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V I V + N ++P F AT+ E +G+ + T A D D NG I+Y I
Sbjct: 3075 VHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTV-----SARDRDAAMNGLIKYSIS 3129
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
++ F I TG + L K L+YE ++ + I A D RT ++T
Sbjct: 3130 SGNEE----GIFAINSS-TGILTLAKALDYELCQKHEMTISAIDGGW---VARTGYCSVT 3181
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
V+V+D +D P+FL P + P + ++ +Q+ D D
Sbjct: 3182 VNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSD-- 3239
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
F + P T ++ ++ + Q + L +KA
Sbjct: 3240 ------------------------LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPD 3275
Query: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
+FA ++I++ N P F Y I E+AP G + + + A D+D
Sbjct: 3276 EERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGE---------VFASDRD 3326
Query: 433 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA--FDGVQ-- 488
+ + +F N F + + Y++ + +DRE+++ + + A F ++
Sbjct: 3327 LGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGI--LDREKEERVSLKVLAKNFGSIRGA 3384
Query: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE-GSNGEITYE 547
+ + V VN+ V+DAND P F Y V + + G V ++A D+D S +Y
Sbjct: 3385 DIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYF 3443
Query: 548 ILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
I G + G F IN TG IT+ ++ Y L+V A D+ P+ ++ V +E +
Sbjct: 3444 IGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDI 3503
Query: 607 PPNNQSPPRFPQLMYSL-EISEAMRVGAVLLNLQATD-----REGDSITYAIENGDPQRV 660
N P L S E+ E R G +++ LQ+TD +G Y + G
Sbjct: 3504 NDNG------PMLTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSY 3557
Query: 661 FNLSETTGILTLGKALDRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDP 719
F+LS T G+L+ + +DRE D Y+ ++T G P +ST TV+I V D NDN P
Sbjct: 3558 FSLS-TAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQNDN-----P 3611
Query: 720 YLPRNLSV-VEEEANAF----VGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNGSIYT 773
R + + V N F +G VK DPD + H SL +LF I G
Sbjct: 3612 SQSRTVEIFVNYYGNLFPGGILGSVKPQDPD--VLDSFHCSLTSGVTSLFSIP--GGTCD 3667
Query: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
R ++L V++ DG HST+T I+V ++ NS
Sbjct: 3668 LNSQPRSTDGTFDLTVLSNDGV----HSTVTSNIRVFFAGFSNATVDNS 3712
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 324 bits (830), Expect = 5e-88
Identities = 329/1221 (26%), Positives = 545/1221 (44%), Gaps = 143/1221 (11%)
Query: 99 TGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNE 158
+G ++ P + V +++ NK+ + +V I + D ND++P F+ Y A VNE
Sbjct: 426 SGLIVTARPLNTVKKEVYKLEVTNKEGD--LKAQVTISIEDANDHTPEFQQPLYDAYVNE 483
Query: 159 LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRK 218
PVGT++ T A+D D G NG I Y I P + F TG I +
Sbjct: 484 SVPVGTSVLT-----VSASDKDKGENGYITYSIASLNLLPFVINQF------TGVISTTE 532
Query: 219 RLNYEDKTR-YFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF--LPCVLVPNTR 275
L++E Y I++A+D R + +T+ + + +D P+F + C V
Sbjct: 533 ELDFESSPEIYRFIVRASDWGSPY--RHESEVNVTIRIGNVNDNSPLFEKVACQGV---- 586
Query: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
++Y + T + AID D + + Y I+ G
Sbjct: 587 ----ISYDFPVGGHIT-----------AVSAIDID-------ELELVKYKIISGNELG-- 622
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD-------- 387
FF+++P + L L + + + + ++ +G L ++I +L
Sbjct: 623 -FFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSF 681
Query: 388 ---------------------------ENNQSPYFTMPSYQGYILESAPVGATISDSLNL 420
E+ ++++ Y +S P + + L +
Sbjct: 682 SCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPV 741
Query: 421 -TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
+ L+I A D D + + S F + T L +L P+DRE Y
Sbjct: 742 GANILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDME--TGQLKVLMPMDREHTDLYLL 799
Query: 480 SITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD 537
+IT +D Q+S ++ I V DANDN+P F + SY V + G +IQ+ A D D
Sbjct: 800 NITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKD 859
Query: 538 EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
GSNGE+TY +L Q F IN +TG++ +A ++ Y+L ++A D A ++ S
Sbjct: 860 LGSNGEVTYSVLTDTQ-QFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFS 918
Query: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
+ T+ + + N+ SP P YS+++ E + VG V+ L+ D + G + Y++ N
Sbjct: 919 VVTLKVFLDDVNDCSPAFIPS-SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVN 977
Query: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVND 712
D F + + +G + L K LD E Y L + A D GRP S+ + V + V DVN+
Sbjct: 978 -DYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNE 1036
Query: 713 NAPVFDPYLPRNLSVVEEEANAFVG----QVKATDPDAGINGQVHYSLGNFNNLFRIT-- 766
N + PY P V + N+ +G QV A D D+G +G++ YS+ + + L R +
Sbjct: 1037 N--LHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSID 1094
Query: 767 -SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 825
+G I A L+RE Y L V ATD V P +ST+ + I+V D++DN+P+ + Y
Sbjct: 1095 DESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYY 1154
Query: 826 VLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDY 882
+V EN P +++QI+A+D D +N ++YRI S ++FFA++ TG ++ R LD
Sbjct: 1155 PVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDR 1214
Query: 883 EAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD-- 938
E Q+A V D G P +T+ V+V+ D ND P F +++Y+ + P+
Sbjct: 1215 E----QQAEHFLEVTVTD--GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQ-IKLPERD 1267
Query: 939 -AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
+G PI +A D D P + + Y + D F ++ +G V +R
Sbjct: 1268 RKKRGEPIYRAFAFDRDEG--PNAEISYSIVDGN---DDGKFFIDPKTGMVSSRKQFTAG 1322
Query: 998 PTTIFKLVVVAFDDGEPVMSSSATVKILVLH---PGEIPRFTQEEYRPPPVSELATKGTM 1054
I L + A D+G P SS+A + I + P IP E + V E +
Sbjct: 1323 SYDI--LTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEI 1380
Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLE 1113
VGV+S N + + IV GN + F G I + PLD E R+ Y + V+ D
Sbjct: 1381 VGVVSVQPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
Query: 1114 VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT 1173
V + +V+I++ D N++ P F + Y +SED T +L+++ATD+D
Sbjct: 1441 VAV-----------TQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE 1489
Query: 1174 GNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLS 1233
+ I I K F ++ TG++ TA + + ++ D
Sbjct: 1490 KHKLSYTVHSSIDSISMRK--FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRR 1547
Query: 1234 GKADVLVSVVNQLDMQVIVSN 1254
A V+V+V + D +N
Sbjct: 1548 NLARVIVNVEDANDHSPYFTN 1568
Score = 311 bits (796), Expect = 4e-84
Identities = 317/1122 (28%), Positives = 504/1122 (44%), Gaps = 104/1122 (9%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V I V N SP F +Y A V E GT + ATD D G GQI Y I
Sbjct: 2481 QVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI-----HVRATDGDPGTYGQISYAI 2535
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTR--YFVIIQANDRAQNLNERRTTTT 249
+ + D F I G ++ +RL+ E+ + ++A D RTT
Sbjct: 2536 I----NDFAKDRFLIDS--NGQVITTERLDRENPLEGDVSIFVRALDGGG-----RTTFC 2584
Query: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
T+ V V+D +D P F+ + Y+A++ ++ + +QAID
Sbjct: 2585 TVRVIVVDENDNAPQFMT------------VEYRASVRA-----DVGRGHLVTQVQAIDP 2627
Query: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
D I YS+ + P + N+ + +KA
Sbjct: 2628 DDGANSR-----ITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAV- 2681
Query: 370 DNGHPLP-AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
D G P+ + ++I +L P FT Y I E +G+T+ D+L + +
Sbjct: 2682 DGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTV-DTLRILPSQNVWF 2740
Query: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---FD 485
+ E PE N+ +F + Q T + L + +DRE + F + A D
Sbjct: 2741 STVNGER---PE-----NNKGGIFVIEQE--TGTIKLDKRLDRETSPAFHFKVAATIPLD 2790
Query: 486 GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
V V V+I+V+D NDN P F SYD + M G + Q+ A+D D G+NG++T
Sbjct: 2791 KVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVT 2850
Query: 546 YEILVGAQGD-----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Y + +Q + F I+ TG I+ ++ T+ +V A+D A +S
Sbjct: 2851 YSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGE-AFSLSSTAL 2909
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGD 656
V + V N+ +P F Q +Y + E+ G V+ L DR+ + +Y I G+
Sbjct: 2910 VSVRVTDINDNAPV-FAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGN 2968
Query: 657 PQRVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
P+ F L ++ + + + LDRE D Y L ITA+DG + A V + V+DVNDN+
Sbjct: 2969 PRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGL--FVTQAMVEVSVSDVNDNS 3026
Query: 715 PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN--LFRITSNGSIY 772
PV D L + +N + +V A D D G NG + YSL N F +G +
Sbjct: 3027 PVCDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELK 3086
Query: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
T L+RE Y L+ ATDG S + L ++ D++DN PVF++ Y V EN
Sbjct: 3087 TLALLDRERIPVYSLMAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYENT 3144
Query: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
+ +++A D D+G N V Y + + F++ +G + L + LD E Q++
Sbjct: 3145 ATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE----QQS 3199
Query: 891 SITFLVEAFDIY-GTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 949
S V A D G + TVT+ V D+ND PPVF +R Y V D GT + V+
Sbjct: 3200 SYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVF 3259
Query: 950 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF 1009
A D R + Q F++ +G + L+ E F LVV A
Sbjct: 3260 ATSKDIGTNAEITYLIRSGNEQ-----GKFKINPKTGGISVSEVLDYELCKRFYLVVEAK 3314
Query: 1010 DDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISAAAI----N 1064
D G P +S+ ATV I + + P +F+Q+ Y +SE A G V ++ A + N
Sbjct: 3315 DGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAV-ISEDALVGDSVILLIAEDVDSQPN 3373
Query: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
I +SIV+G+ ++ F ++ + G++ V LD E + Y L VQA + +P+
Sbjct: 3374 GQIHFSIVNGDRDNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQA-------VDSGIPAM 3426
Query: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
S+TA V I+I D N++ PVF Y + E+ + TS+L++ TD+D+ + I
Sbjct: 3427 SSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSI 3486
Query: 1185 IPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
+ +E E FV++ + G++++A++F + + V A D
Sbjct: 3487 LSGNEE--EEFVLDPH-GILRSAVVFQHTESLEYVLCVQAKD 3525
Score = 310 bits (795), Expect = 6e-84
Identities = 327/1181 (27%), Positives = 541/1181 (45%), Gaps = 133/1181 (11%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
I V D NDNSP F +SY + E + +GT I A D D G NG++ Y + +
Sbjct: 819 INVEDANDNSPVFIQDSYSVNILESSGIGTEII-----QVEARDKDLGSNGEVTYSVLTD 873
Query: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
N + TG + + +L+ E K Y + I+A D+A++ ++ + TL V
Sbjct: 874 TQQFAINSS-------TGIVYVADQLDRESKANYSLKIEARDKAES-GQQLFSVVTLKVF 925
Query: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
+ D +D P F+P ++ E+L V ++ D D +
Sbjct: 926 LDDVNDCSPAFIPSSY-----------------SVKVLEDLPVGTVIAWLETHDPDLGLG 968
Query: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
+ YS++ DY F + + + L + ++ + Q ++L ++A+ D G P
Sbjct: 969 GQ-----VRYSLV----NDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAK-DKGRP 1018
Query: 375 --LPAFAGLHIEILD--ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
L + + + +E++D EN +PYF + G + E++ +G TS L++ A D
Sbjct: 1019 VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIG---------TSVLQVTARD 1069
Query: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
+D +D E+ + D + + + + +T +DRE +Y ++ A D V
Sbjct: 1070 ED--SGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVP 1127
Query: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
+ V I+V D NDN P E Y V + SVIQ+ A D D SN ++TY I
Sbjct: 1128 LYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI 1187
Query: 549 LVG-AQGDFIINKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVL 606
G Q F IN TGLIT ++ + L V D P ++ S V ++VL
Sbjct: 1188 TSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVL 1245
Query: 607 PPNNQSPPRFPQLMYSLEISEAMRV--GAVLLNLQATDRE---GDSITYAIENGDPQRVF 661
N+ P +FP+ +Y +++ E R G + A DR+ I+Y+I +G+ F
Sbjct: 1246 DENDNKP-QFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKF 1304
Query: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---F 717
+ TG+++ K S D IL I A D GRP +STA ++I +P+ F
Sbjct: 1305 FIDPKTGMVSSRKQFTAGSYD--ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTF 1362
Query: 718 D-PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSN-GSIYT 773
D P+ N +V+E + + V + P N + + + GNF++ F G+I
Sbjct: 1363 DEPFY--NFTVMESDRVTEIVGVVSVQP---ANTPLWFDIVGGNFDSAFDAEKGVGTIVI 1417
Query: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
A L+ E R Y + V TDG + + IKVLD +DN P F+ Y V + E++
Sbjct: 1418 AKPLDAEQRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVL 1474
Query: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVK---HFFALHPFTGELSLLRSLDYEAFPDQEA 890
T ILQIEA D D +SY + S F + P TG L LD+EA
Sbjct: 1475 PDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHIL 1534
Query: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
+I + F + A V V V+D ND+ P F+ +Y+ V A G+ + V A
Sbjct: 1535 NIMVRDQEFPYRRNL----ARVIVNVEDANDHSPYFTNPLYEASVFESAALGSAVLQVTA 1590
Query: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP--TTI--FKLVV 1006
D D G A + ++ ++F++E V+ + + +EP TT+ F L +
Sbjct: 1591 LDKDK-GENAELIY----TIEAGNTGNMFKIEP----VLGIITICKEPDMTTMGQFVLSI 1641
Query: 1007 VAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
D G P MS++A V+I V + P+F ++Y+ V+E GT V +ISA +
Sbjct: 1642 KVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAE-VNENVDIGTSVILISAIS-QS 1699
Query: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
+++Y + G+ F IN +GVI LDYE +SY L +QA ++ + +N
Sbjct: 1700 TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMASN------- 1752
Query: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA-------RMFTSVLRVKATDKDTGNYSV 1178
A V I+I DEN++ PVF Y G +SE A + S L ++ATD D+ ++
Sbjct: 1753 --ATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNAL 1810
Query: 1179 MAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADV 1238
+ Y+++ K+ F V++ TG I+T + ++F F V D L+ ++ V
Sbjct: 1811 LVYQIVE---STAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPV 1867
Query: 1239 LVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQI 1279
+++++V N P + + + + +L YV ++
Sbjct: 1868 ------EVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV 1902
Score = 271 bits (694), Expect = 3e-72
Identities = 330/1194 (27%), Positives = 514/1194 (43%), Gaps = 168/1194 (14%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V I V D ND P F +Y T+ E TP+ T++ ATD D G NG+ Y
Sbjct: 143 KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSV-----AQVTATDADIGSNGEFYYYF 197
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNL--NERRTTTT 249
+ D + + T +G I L RLNY++K RY + I A DR L N ++T
Sbjct: 198 KNKVDLFSVHPT-------SGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTA 250
Query: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
L V + ++ P VP + + P TY +VT + +D
Sbjct: 251 KLYVHIERINEHAPTIHVVTHVPFSLEKEP-TYA---------------VVT--VDDLDD 292
Query: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIK 366
N + S SI+ G P D E + E D F ++L ++
Sbjct: 293 GANGEIES------VSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQ 346
Query: 367 AEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
A+ D G P A ++I + F Y I E +P G
Sbjct: 347 AK-DKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGV------------ 393
Query: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
+VA+ K + D E L + F + ++G+ + +P++ +++ Y +T
Sbjct: 394 -VVAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGL---IVTARPLNTVKKEVYKLEVTN 449
Query: 484 FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGE 543
+G +++ V I + DAND+TP F + YD YV + G SV+ ++A D D+G NG
Sbjct: 450 KEGDLKAQ---VTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGY 506
Query: 544 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVG-RTYALTVQAADNAPPAERRNSICTVY 602
ITY I F+IN+ TG+I+ ++ Y V+A+D P R S V
Sbjct: 507 ITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSP-YRHESEVNVT 565
Query: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD-REGDSITYAIENGDPQRVF 661
I + N+ S P F ++ IS VG + + A D E + + Y I +G+ F
Sbjct: 566 IRIGNVNDNS-PLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFF 624
Query: 662 NLSETTGILTLGKALDRE--STDRYILIITASDGRPDGTSTATVNIVVT----------- 708
L+ +G+L L K+L + L ITA+DG + ++NI V
Sbjct: 625 YLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGE-NLADPMSINISVLHGKVSSKSFSC 683
Query: 709 ---------------------------------DVNDNAPVFDPYLPRNLSVVEE-EANA 734
+N P FD P +++V E+ A
Sbjct: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
Query: 735 FVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 791
+ ++KA D D+G NG+V +++ GN ++ F I G + + ++RE D Y L +
Sbjct: 744 NILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITI 803
Query: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851
D + S L I V D +DNSPVF +Y+V + E+ GT I+Q+EA+D DLG+N
Sbjct: 804 YDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSN 863
Query: 852 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPP 907
V+Y + + + FA++ TG + + LD E+ +A+ + +EA D G
Sbjct: 864 GEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRES----KANYSLKIEARDKAESGQQLF 917
Query: 908 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR- 966
+ T+ V + D+ND P F Y V D GT I + E DP +VRY
Sbjct: 918 SVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVI--AWLETHDPDLGLGGQVRYSL 975
Query: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
V+D FE+++ SG + L+ E + L V A D G PV +SS + V++
Sbjct: 976 VNDYN-----GRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
Query: 1026 V------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGN 1075
V LH P F V E + GT V ++A + + I YSI G+
Sbjct: 1031 VVDVNENLHTPYFPDFAV----VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGS 1086
Query: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
F I++ +GVI LD ET SY L V A VV +T +VYIE++
Sbjct: 1087 GLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVV-------PLYSTIEVYIEVE 1139
Query: 1136 DENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGF 1195
D N++ P+ + Y V E++ SV++++A D D+ + + YR+ + F
Sbjct: 1140 DVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRI---TSGNPQNFF 1196
Query: 1196 VVETYTGLIKTA--MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
+ TGLI T L + +F +V TD G S K + VV LD
Sbjct: 1197 AINIKTGLITTTSRKLDREQQAEHF-LEVTVTDG---GPSPKQSTIWVVVQVLD 1246
Score = 271 bits (694), Expect = 3e-72
Identities = 311/1147 (27%), Positives = 492/1147 (42%), Gaps = 115/1147 (10%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V ++V D NDN P F +Y T++E + +GT + S D D N + Y Q
Sbjct: 2273 VDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVS-----IDADSENNKMVHY--Q 2325
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
D S D F I +G I+ + L++E + +++ D ++ +
Sbjct: 2326 IVQDTYNSTDYFHIDSS-SGLILTARMLDHELVQHCTLKVRSIDSGF---PSLSSEVLVH 2381
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
+ + D +D P+F L Y++ + EL +QA D D
Sbjct: 2382 IYISDVNDNPPVF------------NQLIYESYVSELAPRGHF-----VTCVQASDADS- 2423
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
SD + YSIL G F M ++ ++L + + L +
Sbjct: 2424 ----SDFDRLEYSILSGNDRTS---FLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGL- 2475
Query: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
+ A +HI +L N SP F+ +Y + E+ G T + + A D D
Sbjct: 2476 --FTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAG---------TKVIHVRATDGD 2524
Query: 433 IEDTKDPELHLFLNDYT-SVFTVTQTGITRYLTLLQPVDREE--QQTYTFSITAFDGVQE 489
T + +ND+ F + G + + +DRE + + + A DG
Sbjct: 2525 -PGTYGQISYAIINDFAKDRFLIDSNG---QVITTERLDRENPLEGDVSIFVRALDGGGR 2580
Query: 490 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 549
+ V + V+D NDN P F + Y V D+ G V Q+ A+D D+G+N ITY +
Sbjct: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
Query: 550 VGAQ---GDFI-INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
A D + I+ G + + + V+A D P ++S+ VYI V
Sbjct: 2641 SEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPV--KHSLIPVYIHV 2698
Query: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGD-PQR----V 660
LPP P F Q YS I+E +G+ + L+ + ++ ++ NG+ P+ +
Sbjct: 2699 LPPET-FLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQ--NVWFSTVNGERPENNKGGI 2755
Query: 661 FNLSETTGILTLGKALDRESTDRYILIITASD--GRPDGTSTATVNIVVTDVNDNAPVFD 718
F + + TG + L K LDRE++ + + A+ + D T V+I V D+NDN PVF+
Sbjct: 2756 FVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFE 2815
Query: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFN------NLFRITSN-GSI 771
+ + + QV+A D D G NGQV YSL + + F I SN G I
Sbjct: 2816 TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWI 2875
Query: 772 YTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
T L+ E + VVA+D G ST ++++V DI+DN+PVF Y V+E
Sbjct: 2876 STLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKE 2935
Query: 831 NLPAGTTILQIEAKD---VDLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAF 885
+ P G + + D D+ VSY I + FAL E + + R LD E
Sbjct: 2936 SDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE-- 2993
Query: 886 PDQEASITFL-VEAFD-IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
E I FL + A D ++ T A V V V D+ND PV + Y ++ D
Sbjct: 2994 ---EQDIYFLNITATDGLFVTQ----AMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNK 3046
Query: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
I V A+DAD +RY + + S F ++ +SG + T L+ E ++
Sbjct: 3047 IILKVSAKDADIGS--NGYIRYSL----YGSGNSEFFLDPESGELKTLALLDRERIPVYS 3100
Query: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
L+ A D G S+ + IL P F+ + Y ATK + V +
Sbjct: 3101 LMAKATDGGGRFCQSNIHL-ILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPD 3159
Query: 1061 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
IN+ +VYS+ + + F I++ +G+I + PLD E ++SY + V+A
Sbjct: 3160 IGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATD------QSP 3212
Query: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
S S+ V I + D N++PPVF+++ Y+ V ED T VL V AT KD G + +
Sbjct: 3213 GQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEIT 3272
Query: 1181 YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
Y LI ++GK F + TG I + + F V A D LS A V +
Sbjct: 3273 Y-LIRSGNEQGK--FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVNI 3329
Query: 1241 SVVNQLD 1247
++ + D
Sbjct: 3330 NLTDVND 3336
Score = 261 bits (668), Expect = 3e-69
Identities = 309/1164 (26%), Positives = 502/1164 (43%), Gaps = 129/1164 (11%)
Query: 81 VDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRI 135
+ Y ++ D K ++S G+V LDR+ P+ + + V+ ++ G + VR+
Sbjct: 2531 ISYAIINDFAKDRFLIDSNGQVITTERLDRENPLE-GDVSIFVRALDGG-GRTTFCTVRV 2588
Query: 136 VVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNP 195
+V D NDN+P F Y A+V G + A D DDG N +I Y + Y+
Sbjct: 2589 IVVDENDNAPQFMTVEYRASVRADVGRGHLV-----TQVQAIDPDDGANSRITYSL-YSE 2642
Query: 196 DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDV 255
+ D EI D +++ + N N+ + T + V
Sbjct: 2643 ASVSVADLLEI-----------------DPDNGWMVTKG-----NFNQLKNTVLSFFVKA 2680
Query: 256 LDG-----DDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
+DG L P+++ VL P T +P + I I +
Sbjct: 2681 VDGGIPVKHSLIPVYIH-VLPPET----------FLPSFTQSQYSFTIAEDTAIGSTVDT 2729
Query: 311 RNIQPPSDRPGILYSILVG-TPEDYP-RFFHMHPRTAELSLLEPVNRD----FHQKFDLV 364
I P + + +S + G PE+ F + T + L + ++R+ FH K
Sbjct: 2730 LRILPSQN---VWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT 2786
Query: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
I ++ + + + I++LD N+ P F SY I+E PVG ++ +
Sbjct: 2787 IPLDKVD---IVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTKLTQ-------V 2836
Query: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
R + +D LH + T +++ L+ +D E T+TFS+ A
Sbjct: 2837 RAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVAS 2896
Query: 485 D---GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS- 540
D S +V+++V D NDN P F + Y V PG+ V L+ D D
Sbjct: 2897 DLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV 2956
Query: 541 NGEITYEILVG-AQGDFIIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
N +++Y I G +G F + ++ + + ++ Y L + A D +
Sbjct: 2957 NRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITATDGLFVTQ---- 3012
Query: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIEN 654
V + V N+ SP Q+ Y+ + E + ++L + A D + S I Y++
Sbjct: 3013 -AMVEVSVSDVNDNSPV-CDQVAYTALLPEDIPSNKIILKVSAKDADIGSNGYIRYSL-Y 3069
Query: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
G F L +G L LDRE Y L+ A+DG + +++++ DVNDN
Sbjct: 3070 GSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG-GGRFCQSNIHLILEDVNDNP 3128
Query: 715 PVF--DPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRI-TSNG 769
PVF D Y N V E A A + +V+A DPD GIN +V YSL + +F I +S+G
Sbjct: 3129 PVFSSDHY---NTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADSAGGVFSIDSSSG 3185
Query: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTL-TLAIKVLDIDDNSPVFTNSTYTVLV 828
I L+RE + Y + V ATD + S+L T+ I VLDI+DN PVF Y V V
Sbjct: 3186 IIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTV 3245
Query: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 886
E+ GT +L + A D+G N ++Y IRS + F ++P TG +S+ LDYE
Sbjct: 3246 PEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELC- 3304
Query: 887 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 946
+VEA D +ATV + + D+ND PP FS+ +Y +++ DA+ G +
Sbjct: 3305 ---KRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVI 3361
Query: 947 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 1006
+ AED D P ++ + + + + F V+ G V + L+ E + + L+V
Sbjct: 3362 LLIAEDVD--SQPNGQIHFSIVNGD---RDNEFTVDPVLGLVKVKKKLDRERVSGYSLLV 3416
Query: 1007 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1065
A D G P MSS+ATV I + + P FT Y + E GT + + +
Sbjct: 3417 QAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANY-TAVIQENKPVGTSILQLVVTDRDS 3475
Query: 1066 -----SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1120
+SI+SGNEE+ F + + G++ + YVL VQA +
Sbjct: 3476 FHNGPPFSFSILSGNEEEEF-VLDPHGILRSAVVFQHTESLEYVLCVQA-------KDSG 3527
Query: 1121 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1180
P + + + + + +E+ H P ED + ++ ATD+D Y V+
Sbjct: 3528 KPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHATDQDM--YDVLT 3585
Query: 1181 YRLIIPPIKEGKEGFVVETYTGLI 1204
+ L E K F V ++ G I
Sbjct: 3586 FAL----KSEQKSLFKVNSHDGKI 3605
Score = 259 bits (662), Expect = 2e-68
Identities = 303/1195 (25%), Positives = 533/1195 (44%), Gaps = 136/1195 (11%)
Query: 74 ELSLKDNVDYWVLMDPVKQMLFLNSTGRV-----LDRDPPMNIHSIVVQVQCINKKVGTI 128
+L V Y VL D +Q +STG V LDR+ N +S+ ++ + + G
Sbjct: 859 DLGSNGEVTYSVLTD-TQQFAINSSTGIVYVADQLDRESKAN-YSLKIEARD-KAESGQQ 915
Query: 129 IYHEV--RIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQ 186
++ V ++ + D ND SP F SY V E PVGT I + D D G GQ
Sbjct: 916 LFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP-----DLGLGGQ 970
Query: 187 IEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT 246
+ Y + + N FEI +G I L K L+YE + Y + ++A D+ + ++ +
Sbjct: 971 VRYSLVND-----YNGRFEID-KASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVS--LS 1022
Query: 247 TTTTLTVDVLDGDDL--GPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
+ + + V+V+D ++ P F +V + ++ N I T +
Sbjct: 1023 SVSFVEVEVVDVNENLHTPYFPDFAVVGSVKE-------------------NSRIGTSVL 1063
Query: 305 QAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
Q +D + S R G I YSI G+ F + + ++ + ++R+ + L
Sbjct: 1064 QVTARDED----SGRDGEIQYSIRDGSGLGR---FSIDDESGVITAADILDRETMGSYWL 1116
Query: 364 VIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
+ A PL + ++IE+ D N+ +P + P Y ++E++P ++
Sbjct: 1117 TVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV--------- 1167
Query: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVDREEQQTYTFSIT 482
++I A D D + + + + F + +TG+ T + +DRE+Q + +T
Sbjct: 1168 IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT--TTSRKLDREQQAEHFLEVT 1225
Query: 483 AFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADE 538
DG + + V +QV+D NDN P FPE Y + + R G+ + + A D DE
Sbjct: 1226 VTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDE 1285
Query: 539 GSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
G N EI+Y I+ G G F I+ TG+++ + G LT++A DN P +++S
Sbjct: 1286 GPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK--QFTAGSYDILTIKAVDNGRP--QKSS 1341
Query: 598 ICTVYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
++IE + PP + P F + Y+ + E+ RV ++ + + + + I G
Sbjct: 1342 TARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIV-GVVSVQPANTPLWFDIVGG 1400
Query: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
+ F+ + G + + K LD E Y + + +DG + V I V D NDN P
Sbjct: 1401 NFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGT--NVAVTQVFIKVLDNNDNGP 1458
Query: 716 VFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAG--INGQVHYSLGNFN-NLFRIT-SNG 769
F P + E+ + + Q++ATD D ++ VH S+ + + FRI S G
Sbjct: 1459 EFSQ--PNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTG 1516
Query: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
+YTA +L+ E +D + L ++ D R + + + V D +D+SP FTN Y V
Sbjct: 1517 VLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVF 1576
Query: 830 ENLPAGTTILQIEAKDVDLGANVS--YRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 887
E+ G+ +LQ+ A D D G N Y I + + F + P G +++ + PD
Sbjct: 1577 ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKE------PD 1630
Query: 888 QEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
F++ PP AT V + V ++ P F + Y+ V + GT +
Sbjct: 1631 MTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSV 1690
Query: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
+ A + S + Y V D IF + SG + T+ L+ E T+ ++L+
Sbjct: 1691 ILISA-------ISQSTLIYEVKDGDI---NGIFTINPYSGVITTQKALDYERTSSYQLI 1740
Query: 1006 VVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAI- 1063
+ A + M+S+ATV I ++ + P F +Y +SE A ++V + + +
Sbjct: 1741 IQATNMAG--MASNATVNIQIVDENDNAPVFLFSQY-SGSLSEAAPINSIVRSLDNSPLV 1797
Query: 1064 ----------NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSL 1112
N +VY IV + F +++ TG I LD+ET + V DS
Sbjct: 1798 IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSG 1857
Query: 1113 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
L + + +V IE+ D N++PPVF + + + + VL+V ATD D
Sbjct: 1858 SPQL------TAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPD 1911
Query: 1173 TGNYSVMAYRLIIPPIKEGK-EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
+ + Y L+ EG + F++++ +G++ + +N+ + ++ V +D
Sbjct: 1912 SEVPPELTYSLM-----EGSLDHFLIDSNSGVL--TIKNNNLSKDHYMLIVKVSD 1959
Score = 256 bits (655), Expect = 1e-67
Identities = 308/1260 (24%), Positives = 511/1260 (40%), Gaps = 200/1260 (15%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
VRI V +++ P F H+ Y A VNE +GT++ S + +T I + +G I +
Sbjct: 1657 VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVIL-ISAISQSTLIYEVKDGDINGIFT 1715
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
NP +G I +K L+YE + Y +IIQA + A + T+
Sbjct: 1716 INP--------------YSGVITTQKALDYERTSSYQLIIQATNMAG-----MASNATVN 1756
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
+ ++D +D P+FL ++ L+ A I + + +P++ I+A D D N
Sbjct: 1757 IQIVDENDNAPVFL------FSQYSGSLSEAAPINSIVRSLDNSPLV----IRATDADSN 1806
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
++Y I+ T + +FF + T + + ++ + F +
Sbjct: 1807 RNAL-----LVYQIVESTAK---KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGS 1858
Query: 373 HPLPAFAGL--HIEILDENNQSPYFT---------MPSYQG------------------- 402
L A + + +IE+ D N+ P FT +P+Y G
Sbjct: 1859 PQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPEL 1918
Query: 403 -YILESAPVGATISDSLNLTSPLRIVALDKD----------------------IEDTKDP 439
Y L + + DS + ++ L KD +++ D
Sbjct: 1919 TYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDGKFYSTSMVTIMVKEAMDS 1978
Query: 440 ELHLFLNDYTSVFTVTQTGITRYL----------------------------------TL 465
LH + Y++ + T IT+ T
Sbjct: 1979 GLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTT 2038
Query: 466 LQPVDREEQQTYTFSITA---FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
P DREEQ+ Y + A D ++ + V+V + + D NDN+P F + Y V D
Sbjct: 2039 GVPFDREEQELYELVVEASRELDHLRVAR-VVVRVNIEDINDNSPVFVGLPYYAAVQVDA 2097
Query: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT-YAL 581
PG + Q+TA+D D+G NGE+TY +L G F IN +G + + + Y +
Sbjct: 2098 EPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
Query: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
T+ A D P S+ T + N++ P F + Y+ ++E +R+ +L++ AT
Sbjct: 2157 TILAKDGGKP-----SLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINAT 2211
Query: 642 DREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTA 701
EG I Y I +GDP + FN+ TG+L + LD E T Y L I ASD +
Sbjct: 2212 SPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASDALTGARAEV 2271
Query: 702 TVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--- 756
TV+++V DVNDN P+FD P + + E + V QV + D D+ N VHY +
Sbjct: 2272 TVDLLVNDVNDNPPIFDQ--PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQD 2329
Query: 757 -GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
N + F I +S+G I TA L+ E+ + L V + D S + + I + D++D
Sbjct: 2330 TYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVND 2389
Query: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
N PVF Y V E P G + ++A D D + Y I S + F + +G
Sbjct: 2390 NPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSG 2449
Query: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
++L P +++ F A V + V N Y P FS+ Y
Sbjct: 2450 VITLSNHRKQRMEPLYSLNVSVSDGLF-------TSTAQVHIRVLGANLYSPAFSQSTYV 2502
Query: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
V + GT + V A D DP ++ Y + + + F + + +G+VIT
Sbjct: 2503 AEVRENVAAGTKVIHVRATDGDPG--TYGQISYAIIN---DFAKDRFLI-DSNGQVITTE 2556
Query: 993 NLNEEPTT--IFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELA 1049
L+ E + V A D G ++ TV+++V+ + P+F EYR +++
Sbjct: 2557 RLDRENPLEGDVSIFVRALDGGG--RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVG 2614
Query: 1050 TKGTMVGVISAA----AINQSIVYSI---VSGNEEDTFGINNITGVIYVNGPLDYETRTS 1102
+G +V + A N I YS+ S + D I+ G + G + T
Sbjct: 2615 -RGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTV 2673
Query: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
V+A + +P K + VYI + P F + Y ++ED + ++
Sbjct: 2674 LSFFVKA-------VDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYSFTIAEDTAIGST 2726
Query: 1163 VLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKF 1220
V ++ +S + E +G FV+E TG IK F F
Sbjct: 2727 VDTLRILPSQNVWFST-----VNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHF 2781
Query: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIP 1280
+V AT K D++ +V +D++V+ N + E T D + E +P
Sbjct: 2782 KVAATIPL-----DKVDIVFTV--DVDIKVLDLNDNKPVFE------TSSYDTIIMEGMP 2828
Score = 253 bits (647), Expect = 8e-67
Identities = 284/1096 (25%), Positives = 477/1096 (43%), Gaps = 112/1096 (10%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V I V D NDN P F +Y T++E T I ATD D+ ++ Y +
Sbjct: 1445 QVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEIL-----QIEATDRDE--KHKLSYTV 1497
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
++ D S F I TG + +RL++E + ++ + I D Q RR +
Sbjct: 1498 -HSSIDSISMRKFRIDPS-TGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRRNLARVI 1553
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
V+V D +D P F PL Y+A++ E L ++ + A+D+D+
Sbjct: 1554 -VNVEDANDHSPYFT-----------NPL-YEASVFESAA---LGSAVLQ--VTALDKDK 1595
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+ ++Y+I G + F + P +++ + + +F L IK
Sbjct: 1596 G-----ENAELIYTIEAGNTGN---MFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQG 1647
Query: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
P+ A A + I + +N P F YQ + E+ +G TS + I A+ +
Sbjct: 1648 SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIG---------TSVILISAISQ 1698
Query: 432 D--IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
I + KD D +FT+ + +T + +D E +Y I A +
Sbjct: 1699 STLIYEVKD-------GDINGIFTINP--YSGVITTQKALDYERTSSYQLIIQATNMAGM 1749
Query: 490 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQ--------LTAVDADEGSN 541
+ VNIQ++D NDN P F Y + ++ P +S+++ + A DAD N
Sbjct: 1750 ASNATVNIQIVDENDNAPVFLFSQYSGSL-SEAAPINSIVRSLDNSPLVIRATDADSNRN 1808
Query: 542 GEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
+ Y+I+ A+ F ++ +TG I ++ + V D+ P S
Sbjct: 1809 ALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVE 1868
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDP 657
V IEV N+ +PP F Q ++ + VG +L + ATD + + +TY++ G
Sbjct: 1869 VNIEVTDVND-NPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGSL 1927
Query: 658 QRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF 717
F + +G+LT+ + S D Y+LI+ SDG+ ST+ V I+V + D+ F
Sbjct: 1928 DH-FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDGK--FYSTSMVTIMVKEAMDSGLHF 1982
Query: 718 DPYLPRNLSVVEEEANAFVGQVKATDPDAG-INGQVHYSLGNFNNLFRITSNGSIY--TA 774
S E N + +V + +N + YS+ N N F+I S + T
Sbjct: 1983 TQSF---YSTSISENNTNITKVAIVNAVGNRLNEPLKYSILNPGNKFKIKSTSGVIQTTG 2039
Query: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
V +RE ++ YELVV A+ H R + + + + + DI+DNSPVF Y V+ +
Sbjct: 2040 VPFDREEQELYELVVEASRELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEP 2099
Query: 835 GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
GT I Q+ A D D G N + F ++P +G + L EAF ++I +
Sbjct: 2100 GTLIYQVTAIDKDKGPNGEVTYVLQDDYGHFEINPNSGNVIL-----KEAFNSDLSNIEY 2154
Query: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
V G P +V + + +N PVF K Y V D TPI ++ A +
Sbjct: 2155 GVTILAKDGGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE 2214
Query: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
G + Y + D P F ++ D+G + L+ E T+ +KL + A D
Sbjct: 2215 GQG-----IIYIIIDGD---PFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRA-SDALT 2265
Query: 1015 VMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGT----MVGVISAAAINQSIVYS 1070
+ TV +LV + P + +SE + GT +V + + + N+ + Y
Sbjct: 2266 GARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQ 2325
Query: 1071 IVSG--NEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
IV N D F I++ +G+I LD+E VQ +L+V + PS S+
Sbjct: 2326 IVQDTYNSTDYFHIDSSSGLILTARMLDHEL-------VQHCTLKVRSIDSGFPSLSSEV 2378
Query: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
V+I I D N++PPVF + Y VSE A V V+A+D D+ ++ + Y ++
Sbjct: 2379 LVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSIL---S 2435
Query: 1189 KEGKEGFVVETYTGLI 1204
+ F++++ +G+I
Sbjct: 2436 GNDRTSFLMDSKSGVI 2451
Score = 238 bits (607), Expect = 4e-62
Identities = 294/1133 (25%), Positives = 485/1133 (42%), Gaps = 144/1133 (12%)
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
V E PVG I A D D G NG++ + I D ++ F I M TG +
Sbjct: 735 VKEDLPVGANILK-----IKAYDADSGFNGKVLFTIS----DGNTDSCFNID-METGQLK 784
Query: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
+ ++ E Y + I D N ++++ LT++V D +D P+F+
Sbjct: 785 VLMPMDREHTDLYLLNITIYDLG---NPQKSSWRLLTINVEDANDNSPVFIQD------- 834
Query: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
+Y I E + I T IQ +D+++ + + YS+L T +
Sbjct: 835 -----SYSVNILE-------SSGIGTEIIQVEARDKDLGSNGE---VTYSVLTDTQQ--- 876
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPAFAGLHIEILDENNQSP 393
F ++ T + + + ++R+ + L I+A + ++G L + L + + D N+ SP
Sbjct: 877 --FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSP 934
Query: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL-------FLN 446
F SY +LE PVG I+ +T DP+L L +N
Sbjct: 935 AFIPSSYSVKVLEDLPVGTVIA-----------------WLETHDPDLGLGGQVRYSLVN 977
Query: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDAN 503
DY F + + + + L + +D E+QQ Y ++ A D V S V ++V+D N
Sbjct: 978 DYNGRFEIDKA--SGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVN 1035
Query: 504 DN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINK 560
+N TP FP+ + V + R G SV+Q+TA D D G +GEI Y I G+ G F I+
Sbjct: 1036 ENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDD 1095
Query: 561 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 620
+G+IT A ++ +Y LTV A D S VYIEV N+ +P +
Sbjct: 1096 ESGVITAADILDRETMGSYWLTVYATDRG--VVPLYSTIEVYIEVEDVNDNAPLTSEPIY 1153
Query: 621 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL-TLGKAL 676
Y + + + + +V + +QA D + S +TY I +G+PQ F ++ TG++ T + L
Sbjct: 1154 YPVVMENSPKDVSV-IQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKL 1212
Query: 677 DRESTDRYILIITASDGRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
DRE + L +T +DG P ST V + V D NDN P F P + + E +
Sbjct: 1213 DREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQF-PEKVYQIKLPERDRKKR 1271
Query: 736 ---VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
+ + A D D G N ++ YS+ GN + F I + ++ K Y L +
Sbjct: 1272 GEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK-QFTAGSYDILTIK 1330
Query: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPV-------FTNSTYTVLVEENLPAGTTILQIEA 843
A D + ST L I+ + SP+ F N +TV+ + + ++ ++
Sbjct: 1331 AVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN--FTVMESDRVTEIVGVVSVQP 1388
Query: 844 KDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
+ L + I F G + + + LD E Q + VE D G
Sbjct: 1389 ANTPLW----FDIVGGNFDSAFDAEKGVGTIVIAKPLDAE----QRSIYNMSVEVTD--G 1438
Query: 904 TMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
T +A V +K D ND P FS+ Y ++ D + T I + A D D +
Sbjct: 1439 T---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDEKHKLSY 1495
Query: 962 RVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSAT 1021
V +D + F ++ +G + T L+ E L ++ D P + A
Sbjct: 1496 TVHSSIDSISM----RKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLAR 1551
Query: 1022 VKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNE 1076
V + V + P FT Y V E A G+ V ++A N ++Y+I +GN
Sbjct: 1552 VIVNVEDANDHSPYFTNPLYE-ASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNT 1610
Query: 1077 EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD 1136
+ F I + G+I + D T +VL ++ + + P S TA V I +
Sbjct: 1611 GNMFKIEPVLGIITICKEPDMTTMGQFVLSIK-------VTDQGSPPMSATAIVRISVTM 1663
Query: 1137 ENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-- 1194
+N P F K Y V+E+ + TSV+ + A + T +I +K+G
Sbjct: 1664 SDNSHPKFIHKDYQAEVNENVDIGTSVILISAISQST----------LIYEVKDGDINGI 1713
Query: 1195 FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
F + Y+G+I T R S ++ + AT+ G++ A V + +V++ D
Sbjct: 1714 FTINPYSGVITTQKALDYERTSSYQLIIQATN--MAGMASNATVNIQIVDEND 1764
Score = 186 bits (473), Expect = 1e-46
Identities = 235/979 (24%), Positives = 420/979 (42%), Gaps = 137/979 (13%)
Query: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
+NR+ + L++K G L A+ ++I++LD N+ P F+ +Y I ES P+
Sbjct: 117 LNREIQDNYLLIVKGSV-RGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPL-- 173
Query: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
TS ++ A D DI + E + + + +F+V T + ++L ++ +
Sbjct: 174 -------RTSVAQVTATDADI--GSNGEFYYYFKNKVDLFSVHPT--SGVISLSGRLNYD 222
Query: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
E+ Y I A D GV + + V+I+ + N++ PT +++ V +
Sbjct: 223 EKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERI--NEHAPTIHVVTH-VPFSLEKE 279
Query: 524 PGDSVIQLTAVDADEGSNGEI-TYEILVGAQGD-FIINKTTGLITIAPGVEM------IV 575
P +V+ T D D+G+NGEI + I+ G D F + K + E
Sbjct: 280 PTYAVV--TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESF 337
Query: 576 GRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 635
Y LT+QA D P ++ +++ VYI P + P RF + +Y + ISE G V+
Sbjct: 338 PYGYNLTLQAKDKGSP-QKCSALKAVYIG-NPTRDTVPIRFEKEVYDVSISEFSPPGVVV 395
Query: 636 LNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
++ + D + Y + G+ F ++ +G++ + L+ + Y L +T
Sbjct: 396 AIVKLSPEPID-VEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVT----NK 450
Query: 696 DGTSTATVNIVVTDVNDNA-----PVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
+G A V I + D ND+ P++D Y+ ++ V V V A+D D G NG
Sbjct: 451 EGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPV-----GTSVLTVSASDKDKGENG 505
Query: 751 QVHYSLGNFNNLFRITS--NGSIYTAVKLNREVR-DYYELVVVATD-GAVHPRHSTLTLA 806
+ YS+ + N L + + G I T +L+ E + Y +V A+D G+ + S + +
Sbjct: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
Query: 807 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFA 866
I++ +++DNSP+F ++ + P G I + A D+D V Y+I S FF
Sbjct: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELVKYKIISGNELGFFY 625
Query: 867 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI----------- 915
L+P +G L L +SL + + + A D P ++V+
Sbjct: 626 LNPDSGVLQLKKSLTNSGI--KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSC 683
Query: 916 -------------------------------VKDMNDYPPVFSKRIYKGM-VAPDAVKGT 943
+N P F K + V D G
Sbjct: 684 RETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGA 743
Query: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
I + A DAD +V + + D S F ++ ++G++ + ++ E T ++
Sbjct: 744 NILKIKAYDADSGF--NGKVLFTISDGN---TDSCFNIDMETGQLKVLMPMDREHTDLYL 798
Query: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA 1062
L + +D G P SS + I V + P F Q+ Y V+ L + G +I A
Sbjct: 799 LNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSY---SVNILESSGIGTEIIQVEA 855
Query: 1063 ------INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVV 1115
N + YS+++ ++ F IN+ TG++YV LD E++ +Y L+++A D E
Sbjct: 856 RDKDLGSNGEVTYSVLTDTQQ--FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESG 913
Query: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
V T KV+++ D N+ P F Y V ED + T + ++ D D G
Sbjct: 914 QQLFSVV----TLKVFLD--DVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGL 967
Query: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
+ Y L + + F ++ +G I+ + ++ ++ V A D KG
Sbjct: 968 GGQVRYSL----VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKD---KG---- 1016
Query: 1236 ADVLVSVVNQLDMQVIVSN 1254
V +S V+ ++++V+ N
Sbjct: 1017 RPVSLSSVSFVEVEVVDVN 1035
Score = 174 bits (441), Expect = 6e-43
Identities = 204/861 (23%), Positives = 361/861 (41%), Gaps = 90/861 (10%)
Query: 469 VDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
++RE Q Y + ++ E VNIQV+D ND P F +Y V + S
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
Query: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAAD 587
V Q+TA DAD GSNGE Y F ++ T+G+I+++ + Y L + A D
Sbjct: 177 VAQVTATDADIGSNGEF-YYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVD 235
Query: 588 NAPPAERRNSICT---VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
N + + +Y+ + N +P + + V ++
Sbjct: 236 RGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDDGAN 295
Query: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD------RYILIITASD-GRPDG 697
G+ + +I GDP F L++ L K +R+ D Y L + A D G P
Sbjct: 296 GEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQK 355
Query: 698 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 757
S + D P+ ++S+ E V + P+ I+ + S G
Sbjct: 356 CSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP-IDVEYKLSPG 414
Query: 758 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNS 816
F+I +G I TA LN ++ Y+L V +G + + + I + D +D++
Sbjct: 415 EDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIEDANDHT 469
Query: 817 PVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGEL 874
P F Y V E++P GT++L + A D D G N ++Y I S + F ++ FTG +
Sbjct: 470 PEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP-FVINQFTGVI 528
Query: 875 SLLRSLDYEAFPDQEASITFLVEAFDIYGT--MPPGIATVTVIVKDMNDYPPVFSKRIYK 932
S LD+E+ P+ F+V A D +G+ VT+ + ++ND P+F K +
Sbjct: 529 STTEELDFESSPE---IYRFIVRASD-WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQ 584
Query: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFPY---PASIFEVEED-- 984
G+++ D G IT V A D D L V+Y++ +++ F Y + + ++++
Sbjct: 585 GVISYDFPVGGHITAVSAIDIDELEL----VKYKIISGNELGFFYLNPDSGVLQLKKSLT 640
Query: 985 -----SGRVITRVNLNE-----EPTTI------FKLVVVAFDDGEPVMSSSATVKILV-- 1026
+G R+ + +P +I K+ +F E ++ K+L+
Sbjct: 641 NSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKA 700
Query: 1027 -------LHPGEI---------PRFTQEEYRPPPVSELATKGTMVGVISA----AAINQS 1066
L G + P F + V E G + I A + N
Sbjct: 701 KANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGK 760
Query: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
++++I GN + F I+ TG + V P+D E Y+ L + + +L P KS+
Sbjct: 761 VLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYL-------LNITIYDLGNPQKSS 813
Query: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
+ I ++D N++ PVF + Y + E + + T +++V+A DKD G+ + Y ++
Sbjct: 814 WRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVL-- 871
Query: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
+ F + + TG++ A ++ + ++ A D G + V + V
Sbjct: 872 ---TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDD 928
Query: 1247 DMQVIVSNVPPTLVEKKIEDL 1267
+ +P + K +EDL
Sbjct: 929 VNDCSPAFIPSSYSVKVLEDL 949
Score = 168 bits (426), Expect = 4e-41
Identities = 278/1139 (24%), Positives = 463/1139 (40%), Gaps = 175/1139 (15%)
Query: 220 LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRP 279
LN E + Y +I++ + R ++L T + + VLD +DL P+F P
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLE----AWTKVNIQVLDMNDLRPLF------------SP 160
Query: 280 LTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFH 339
TY I E TP + VT A D D G Y + F
Sbjct: 161 TTYSVTIAE-STPLRTSVAQVT----ATDADIGSN------GEFYYYFKNKVD----LFS 205
Query: 340 MHPRTAELSLLEPVNRDFHQKFDLVI-------KAEQDNGHPLPAFAGLHIEILDENNQS 392
+HP + +SL +N D ++DL I K +NG A +HIE ++E+ +
Sbjct: 206 VHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEH--A 263
Query: 393 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH---LFLNDYT 449
P + ++ + LE P A +V +D D++D + E+ + D
Sbjct: 264 PTIHVVTHVPFSLEKEPTYA-------------VVTVD-DLDDGANGEIESVSIVAGDPL 309
Query: 450 SVFTVTQTGITRYLTLLQPVDREE------QQTYTFSITAFD-GVQESEPVIVNIQVMD- 501
F + + G ++L + +R++ Y ++ A D G + + + + +
Sbjct: 310 DQFFLAKEG--KWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNP 367
Query: 502 ANDNTP-TFPEISYDVYVYTDMRPG--DSVIQLTAVDADEGSNGEITYEILVGAQG-DFI 557
D P F + YDV + PG ++++L+ D + Y++ G F
Sbjct: 368 TRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID------VEYKLSPGEDAVYFK 421
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
IN +GLI A + + Y L V + A+ T+ IE N P F
Sbjct: 422 INPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLKAQ-----VTISIE---DANDHTPEFQ 473
Query: 618 QLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGK 674
Q +Y ++E++ VG +L + A+D+ E ITY+I + + F +++ TG+++ +
Sbjct: 474 QPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLN-LLPFVINQFTGVISTTE 532
Query: 675 ALDREST-DRYILIITASD-GRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
LD ES+ + Y I+ ASD G P S V I + +VNDN+P+F+ + + +
Sbjct: 533 ELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFP 592
Query: 732 ANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVK--LNREVRD-YYELV 788
+ V A D D + GN F + + + K N +++ + L
Sbjct: 593 VGGHITAVSAIDIDELELVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALR 652
Query: 789 VVATDG------------AVHPRHSTLT-----------LAIKVL--------------- 810
+ ATDG +H + S+ + LA K+L
Sbjct: 653 ITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGF 712
Query: 811 ----DIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKH 863
I+ P F S V V+E+LP G IL+I+A D D G N V + I
Sbjct: 713 LDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDS 772
Query: 864 FFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYP 923
F + TG+L +L +D E +IT +D+ +T+ V+D ND
Sbjct: 773 CFNIDMETGQLKVLMPMDREHTDLYLLNITI----YDLGNPQKSSWRLLTINVEDANDNS 828
Query: 924 PVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV-DDVQFPYPASIFEVE 982
PVF + Y + + GT I V A D D V Y V D Q F +
Sbjct: 829 PVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS--NGEVTYSVLTDTQ------QFAIN 880
Query: 983 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKILVLHPGEI-PRFTQEE 1039
+G V L+ E + L + A D E + S T+K+ + + P F
Sbjct: 881 SSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSS 940
Query: 1040 YRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPL 1095
Y + +L GT++ + + + YS+V+ + F I+ +G I ++ L
Sbjct: 941 YSVKVLEDLPV-GTVIAWLETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKEL 998
Query: 1096 DYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQD--ENNHPPVFQKKFYIGGV 1153
DYE + Y L V+A R S S+ + V +E+ D EN H P F +G V
Sbjct: 999 DYEKQQFYNLTVRAKD------KGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSV 1052
Query: 1154 SEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNM 1213
E++R+ TSVL+V A D+D+G + Y + G F ++ +G+I A +
Sbjct: 1053 KENSRIGTSVLQVTARDEDSGRDGEIQYSI---RDGSGLGRFSIDDESGVITAADILDRE 1109
Query: 1214 RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN--VPPTLVEKKIEDLTEI 1270
+ V ATD L +V + V + D + S P ++E +D++ I
Sbjct: 1110 TMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVI 1168
Score = 145 bits (367), Expect = 2e-34
Identities = 142/576 (24%), Positives = 264/576 (45%), Gaps = 66/576 (11%)
Query: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
G + +++ D NDN P F + Y V E T + T A D D G N
Sbjct: 3110 GRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTAT-KALLTRVQ----AVDPDIGINR 3164
Query: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
++ Y + + S D+ +G I+L + L+ E ++ Y + ++A D Q+ +
Sbjct: 3165 KVVYSLADSAGGVFSIDSS------SGIIILEQPLDREQQSSYNISVRATD--QSPGQSL 3216
Query: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
++ TT+T+ VLD +D P+F RD Y +PE +P T +
Sbjct: 3217 SSLTTVTITVLDINDNPPVF-------ERRD-----YLVTVPEDTSPG-------TQVLA 3257
Query: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
++I ++ I Y I G + F ++P+T +S+ E ++ + ++F LV+
Sbjct: 3258 VFATSKDIGTNAE---ITYLIRSGNEQGK---FKINPKTGGISVSEVLDYELCKRFYLVV 3311
Query: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
+A+ L A A ++I + D N+ P F+ Y I E A VG ++
Sbjct: 3312 EAKDGGTPALSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSV----------- 3360
Query: 426 IVALDKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
I+ + +D++ + ++H + D + FTV + + + + +DRE Y+ + A
Sbjct: 3361 ILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDP--VLGLVKVKKKLDRERVSGYSLLVQA 3418
Query: 484 FD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
D G+ S VNI + D NDN+P F +Y + + G S++QL D D N
Sbjct: 3419 VDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHN 3478
Query: 542 GE-ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
G ++ IL G + + + G++ A + Y L VQA D+ P + ++
Sbjct: 3479 GPPFSFSILSGNEEEEFVLDPHGILRSAVVFQHTESLEYVLCVQAKDSGKPQQVSHTY-- 3536
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQR 659
+ + V+ + P P ++ + + + G V+ + ATD++ D +T+A+++ + +
Sbjct: 3537 IRVRVIEESTHKPTAIPLEIFIVTMEDDF-PGGVIGKIHATDQDMYDVLTFALKS-EQKS 3594
Query: 660 VFNLSETTG-ILTLGKALDRESTDRYILIITASDGR 694
+F ++ G I+ LG LD + +Y+L ++ SDGR
Sbjct: 3595 LFKVNSHDGKIIALG-GLD---SGKYVLNVSVSDGR 3626
Score = 102 bits (253), Expect = 4e-21
Identities = 177/781 (22%), Positives = 303/781 (38%), Gaps = 119/781 (15%)
Query: 505 NTPTFPEISYDVYVYTDMRPGDSVIQLT------AVDADEGSNGEITYEILVGAQGDFII 558
N + + YV + R G ++I L+ V DE G E ++ A F+
Sbjct: 49 NATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVSGDE--EGFFKAEEVIIADFCFLR 106
Query: 559 NKTTGLITIAPGVEMIVGR----TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614
+T G G I+ R Y L V+ + E V I+VL N+ P
Sbjct: 107 IRTKG------GNSAILNREIQDNYLLIVKGSVRGEDLEAWTK---VNIQVLDMNDLRP- 156
Query: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIENGDPQRVFNLSETTGIL 670
F YS+ I+E+ + + + ATD + G+ Y D +F++ T+G++
Sbjct: 157 LFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVD---LFSVHPTSGVI 213
Query: 671 TLGKALDRESTDRYILIITASD------GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
+L L+ + +RY L I A D G +STA + + + +N++AP
Sbjct: 214 SLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVP 273
Query: 725 LSVVEEEANAFVGQVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTAVKLN-RE 780
S+ +E A V D D G NG++ G+ + F + G K+ R+
Sbjct: 274 FSLEKEPTYAVV---TVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERK 330
Query: 781 VRDY------YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV-FTNSTYTVLVEENLP 833
D+ Y L + A D + S L D P+ F Y V + E P
Sbjct: 331 QIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSP 390
Query: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
G + ++ + +V Y++ E +F ++P +G + R L+ T
Sbjct: 391 PGVVVAIVKLSPEPI--DVEYKLSPGEDAVYFKINPRSGLIVTARPLN-----------T 437
Query: 894 FLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 951
E + + T G A VT+ ++D ND+ P F + +Y V GT + TV A
Sbjct: 438 VKKEVYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
Query: 952 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN-EEPTTIFKLVVVAFD 1010
D D + Y + + F + + +G + T L+ E I++ +V A D
Sbjct: 498 DKDKG--ENGYITYSIASLNL----LPFVINQFTGVISTTEELDFESSPEIYRFIVRASD 551
Query: 1011 DGEPVM-SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS--I 1067
G P S V I + + + ++ +S G + +SA I++ +
Sbjct: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
Query: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYE--TRTSYVLRVQAD---------SLEVVL 1116
Y I+SGNE F +N +GV+ + L ++ LR+ A S+ + +
Sbjct: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Query: 1117 ANLRVPSKS--------------------------NTAKVYIEIQDENNHPPVFQKKFYI 1150
+ +V SKS N +++ N P F K F
Sbjct: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
Query: 1151 G-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTGLIKTA 1207
V ED + ++L++KA D D+G + + I +G F ++ TG +K
Sbjct: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLF-----TISDGNTDSCFNIDMETGQLKVL 786
Query: 1208 M 1208
M
Sbjct: 787 M 787
Score = 52.0 bits (123), Expect = 5e-06
Identities = 56/228 (24%), Positives = 102/228 (44%), Gaps = 21/228 (9%)
Query: 1058 ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR--VQADSLEVV 1115
I+ ++ I Y IVSG+EE F + + + + S +L +Q + L +V
Sbjct: 70 ITLIDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIV 129
Query: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
++R KV I++ D N+ P+F Y ++E + TSV +V ATD D G+
Sbjct: 130 KGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
Query: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD----YG-K 1230
Y K + F V +G+I + + ++ + +++A D YG
Sbjct: 190 NGEFYYY-----FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNN 244
Query: 1231 GLSGKADVLVSV--VNQLDMQV-IVSNVP------PTLVEKKIEDLTE 1269
G+S A + V + +N+ + +V++VP PT ++DL +
Sbjct: 245 GVSSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEPTYAVVTVDDLDD 292
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 314 bits (805), Expect = 4e-85
Identities = 332/1228 (27%), Positives = 544/1228 (44%), Gaps = 147/1228 (11%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
+ +VV D NDN P F ESY+ V+E V + I ATD D GPNG + Y I
Sbjct: 808 LHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEII-----QVEATDKDLGPNGHVTYSI- 861
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
T DTF I +TG + + + L+ E + + + I+A D+A+ + +T +
Sbjct: 862 -----VTDTDTFSID-SVTGVVNIARPLDRELQHEHSLKIEARDQARE-EPQLFSTVVVK 914
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
V + D +D P F+P PN R ++ E+L V ++A D D
Sbjct: 915 VSLEDVNDNPPTFIP----PNYR-------------VKVREDLPEGTVIMWLEAHDPDL- 956
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
+ YS+L + F + + + +++ ++ + Q ++L ++A +D G
Sbjct: 957 ----GQSGQVRYSLL----DHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRA-KDKG 1007
Query: 373 HPLPAFAGLHIEI----LDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
P+ + ++E+ ++EN P F+ +G + E APVG+ + + + A
Sbjct: 1008 KPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLV---------MTVSA 1058
Query: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG-- 486
D+D +D E+ + D + V T + +DRE Y ++ A D
Sbjct: 1059 HDEDAR--RDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGV 1116
Query: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
V S + + I+V D NDN P E Y + + SV+Q+ A D D SN ++ Y
Sbjct: 1117 VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMY 1176
Query: 547 EILVG-AQGDFIINKTTGLI-TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
+I G QG F I+ TGLI T + ++ + L V DN P +++I V ++
Sbjct: 1177 KITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPP--KSTIARVIVK 1234
Query: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVG-------AVLLNLQATDRE---GDSITYAIEN 654
+L N + P+F Q Y + + E + L ++ ATD++ I+Y+IE+
Sbjct: 1235 IL-DENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIED 1293
Query: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
G+ F + TG+++ K + I +GRP +ST ++I ++
Sbjct: 1294 GNEHGKFFIEPKTGVVS-SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHI--EWISKPK 1350
Query: 715 PVFDPYLPR----NLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
P +P +V+E + A + V + +P GI + GN+++ F + G
Sbjct: 1351 PSLEPISFEESFFTFTVMESDPVAHMIGVISVEP-PGIPLWFDITGGNYDSHFDVDKGTG 1409
Query: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLT-LAIKVLDIDDNSPVFTNSTYTVLV 828
+I A L+ E + Y L V ATDG + LT + IKV+D +D+ P F+ S Y V++
Sbjct: 1410 TIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFSTSKYEVVI 1465
Query: 829 EENLPAGTTILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAF 885
E+ T ILQI A D D + Y + R P F L P TG L LD+EA
Sbjct: 1466 PEDTAPETEILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
Query: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
+ ++T +V D+ + A + V V D ND+ P F+ YKG V A G+ +
Sbjct: 1526 --HQHTLTVMVRDQDV--PVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
Query: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLV 1005
V A D D + V Y ++ + F ++ G + T L+ + L+
Sbjct: 1582 LQVTALDKDKG--KNAEVLYSIESGNI---GNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
Query: 1006 VVAFDDGEPVMSSSATVKILV-LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAIN 1064
V A D G P MS +V+I V + P+FT +EY +SE + G+ VG+++A +
Sbjct: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEY-SVELSETVSIGSFVGMVTAHS-Q 1694
Query: 1065 QSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK 1124
S+VY I GN D F IN +G I LD+ET Y L +Q ++
Sbjct: 1695 SSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM---------AGL 1745
Query: 1125 SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYS 1177
S V + +QDEN++ PVF + Y G +SE A + + VL ++A D D + +
Sbjct: 1746 STNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNA 1805
Query: 1178 VMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
++ Y ++ P + F +++ TG I T + S F F V D G
Sbjct: 1806 LLVYHIVEPSV---HTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHD------MGTPR 1856
Query: 1238 VLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV------------ 1285
+ + + VI N P + K + + + +L Y G KV+
Sbjct: 1857 LFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTY-----KGVKVITVNATDADSSAF 1911
Query: 1286 ---VESIGARRHGDAFSLEDYTKCDLTV 1310
+ SI G+ FS+ DY LTV
Sbjct: 1912 SQLIYSITEGNIGEKFSM-DYKTGALTV 1938
Score = 301 bits (771), Expect = 4e-81
Identities = 318/1159 (27%), Positives = 513/1159 (44%), Gaps = 111/1159 (9%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+V + V N +SP F Y + E P+ T + + TD D G G + Y I
Sbjct: 2477 QVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVM-----EVKTTDGDSGIYGHVTYHI 2531
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
+ + D F I G I ++L+ E + ++ + + T+
Sbjct: 2532 V----NDFAKDRFYINER--GQIFTLEKLDRETPAEKVISVRLMAKDAG---GKVAFCTV 2582
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
V + D +D P F R Y+ I T ++ + D
Sbjct: 2583 NVILTDDNDNAPQF------------RATKYEVNIGSSAAKG-------TSVVKVLASDA 2623
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+ +D I Y+I + E ++ + ++ E + ++ F ++A DN
Sbjct: 2624 DEGSNAD---ITYAIEADS-ESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAV-DN 2678
Query: 372 GHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
G P L +++IL Q P F+ P Y + E P+G I S + +L
Sbjct: 2679 GSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLV 2738
Query: 431 KDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
K PE N S Q+G L L + +D E + Y FSI A +
Sbjct: 2739 KG----NTPES----NRDESFVIDRQSG---RLKLEKSLDHETTKWYQFSILARCTQDDH 2787
Query: 491 EPVI---VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
E V V+IQV DANDN+P F Y+ ++ ++ G VIQ+ A DAD G+NG++ Y
Sbjct: 2788 EMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYS 2847
Query: 548 I----LVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
+ V F IN TG IT ++ Y + V A+D+ E+ T +
Sbjct: 2848 LDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDH---GEKIQLSSTAIV 2904
Query: 604 EVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSI----TYAIENGDPQ 658
+V + N SPPRF +Y +SE G V+ L TD + + I TY I GDP
Sbjct: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
Query: 659 RVFNLS--ETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPV 716
F + + + + K LDRE D Y+L ITA+DG +S A V + V D NDN+PV
Sbjct: 2965 GQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG--TFSSKAIVEVKVLDANDNSPV 3022
Query: 717 FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYS-LGNFNNLFRIT-SNGSIYTA 774
+ L + + + Q+ ATD D N ++ Y+ LG+ F++ G + T+
Sbjct: 3023 CEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTS 3082
Query: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
L+RE + Y L+V ATDG R ++ + + D++DN+P F+ Y + V EN
Sbjct: 3083 TPLDREEQAVYHLLVRATDGG--GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEP 3140
Query: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
GT + +++A D D G N + Y + F+++ +G + L + LD E +A
Sbjct: 3141 GTLLTRVQATDADAGLNRKILYSL-IDSADGQFSINELSGIIQLEKPLDREL----QAVY 3195
Query: 893 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
T ++A D G AT TVIV D+ND PPVF R Y V+ D + GT + VYA
Sbjct: 3196 TLSLKAVD-QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYA 3254
Query: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
D + + Y + F ++ +G V NL+ E + + L V A D
Sbjct: 3255 ASRDIEA--NAEITYSIISGN---EHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATD 3309
Query: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
G P +S ATV + V + P F+Q+ Y + + +++ V++ A N
Sbjct: 3310 GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSH 3369
Query: 1067 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
I YSI+ GN+ +F I+ + G + V LD ET + Y L VQA ++ P + N
Sbjct: 3370 IHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQA-------SDNGSPPRVN 3422
Query: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
T V I++ D N++ PVF + Y + E+ + SVL++ TD+D+ + + I+
Sbjct: 3423 TTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVT 3482
Query: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
E + F V G++ T+ + ++ QV D +GK +S + +
Sbjct: 3483 GNDE--KAFEVNP-QGVLLTSSAIKRKEKDHYLLQVKVAD------NGKPQ--LSSLTYI 3531
Query: 1247 DMQVIVSNV-PPTLVEKKI 1264
D++VI ++ PP ++ +I
Sbjct: 3532 DIRVIEESIYPPAILPLEI 3550
Score = 291 bits (746), Expect = 3e-78
Identities = 309/1171 (26%), Positives = 506/1171 (43%), Gaps = 133/1171 (11%)
Query: 96 LNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYAT 155
L++TG DR+ +VV+V K + + V+++V D+NDN+P F + YYA
Sbjct: 2032 LSTTGTPFDREQ-QEAFDVVVEVT-EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV 2089
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEI-PLMLTGNI 214
V T VG I A D D G NG++ Y ++ + ++ F+I PL G I
Sbjct: 2090 VKVDTEVGHVI-----RYVTAVDRDSGRNGEVHYYLKEH------HEHFQIGPL---GEI 2135
Query: 215 VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
L+K+ + + +++ TV DG + P F V+VP T
Sbjct: 2136 SLKKQFELDTLNKEYLV--------------------TVVAKDGGN--PAFSAEVIVPIT 2173
Query: 275 RDCRPLTYQAAIPELRTP----EELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
A+P P E I V P+ + + + + YSI G
Sbjct: 2174 ------VMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQAN-----SPEGLKVFYSITDGD 2222
Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL---- 386
P F ++ T ++++ P++ + H + L I+A + G H E+
Sbjct: 2223 PFSQ---FTINFNTGVINVIAPLDFEAHPAYKLSIRATD-------SLTGAHAEVFVDII 2272
Query: 387 --DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF 444
D N+ P F SY + E++ +G TS +++ A D D E + +F
Sbjct: 2273 VDDINDNPPVFAQQSYAVTLSEASVIG---------TSVVQVRATDSDSEPNRGISYQMF 2323
Query: 445 LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDA 502
N S T ++LL+ +D E+ + +T + A DG S VIV + V D
Sbjct: 2324 GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDL 2383
Query: 503 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKT 561
NDN P F + Y+ + G V + A DAD ++ Y IL G F+I+
Sbjct: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSA 2443
Query: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
TG+IT++ + Y+L + +D S V++ V+ N S P F Q Y
Sbjct: 2444 TGIITLSNLHRHALKPFYSLNLSVSDGV-----FRSSTQVHVTVIGGNLHS-PAFLQNEY 2497
Query: 622 SLEISEAMRVGAVLLNLQATDREGDS-----ITYAIENGDPQRVFNLSETTGILTLGKAL 676
+E++E + +++ ++ TD GDS +TY I N + F ++E I TL K L
Sbjct: 2498 EVELAENAPLHTLVMEVKTTD--GDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK-L 2554
Query: 677 DRES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
DRE+ ++ I + + + TVN+++TD NDNAP F
Sbjct: 2555 DRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTS 2614
Query: 736 VGQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVV 790
V +V A+D D G N + Y++ NL +G I T L +++ V
Sbjct: 2615 VVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVR 2674
Query: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
A D + S + + +K+L + P F+ YT V E++P GT I I A+
Sbjct: 2675 AVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVL 2734
Query: 851 NVSYRIRSPEVK--HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 908
+ +PE F + +G L L +SLD+E + SI L M
Sbjct: 2735 YSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSI--LARCTQDDHEMVAS 2792
Query: 909 IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVD 968
+ V++ VKD ND PVF Y+ + + G+ + + A DAD +V Y +D
Sbjct: 2793 V-DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSG--TNGQVMYSLD 2849
Query: 969 DVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKILVL 1027
Q F + ++G + T L+ E +++ VVA D GE + +SS+A V + V
Sbjct: 2850 QSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVT 2909
Query: 1028 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVIS-----AAAINQSIVYSIVSGNEEDTFG 1081
+ PRFT E Y+ VSE +G ++ ++S + IN+ + Y I G+ F
Sbjct: 2910 DVNDSPPRFTAEIYK-GTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
Query: 1082 INNITG--VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1139
+ I +YV PLD E R +Y+L + A + S+ A V +++ D N+
Sbjct: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD----------GTFSSKAIVEVKVLDAND 3018
Query: 1140 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
+ PV +K Y + ED ++++ ATD D + + + Y L + G E F +
Sbjct: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTL----LGSGAEKFKLNP 3074
Query: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGK 1230
TG +KT+ ++ + V ATD G+
Sbjct: 3075 DTGELKTSTPLDREEQAVYHLLVRATDGGGR 3105
Score = 288 bits (738), Expect = 2e-77
Identities = 311/1161 (26%), Positives = 516/1161 (44%), Gaps = 148/1161 (12%)
Query: 116 VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNG 175
++V ++K T +V + V N N P F +Y A +E P+GTT+ +
Sbjct: 436 LEVTTSDRKAST----KVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMS-----LS 486
Query: 176 ATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVI-IQA 234
A D D+G NG + Y I P + D F TG + + L+YE R + + I+A
Sbjct: 487 AVDPDEGENGYVTYSIANLNHVPFAIDHF------TGAVSTSENLDYELMPRVYTLRIRA 540
Query: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP-ELRTPE 293
+D L RR T+ + + +D P+F + + IP +L E
Sbjct: 541 SD--WGLPYRREVEVLATITLNNLNDNTPLF------------EKINCEGTIPRDLGVGE 586
Query: 294 ELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV 353
++ + AID D + + Y I G D FF ++P + LSL +
Sbjct: 587 QIT------TVSAIDAD-------ELQLVQYQIEAGNELD---FFSLNPNSGVLSLKRSL 630
Query: 354 NRDFHQK---FDLVIKAEQDNGHPLPAFAGLHI----------------------EILDE 388
K L I A P + + + ++L
Sbjct: 631 MDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQA 690
Query: 389 NN-------QSPYFTMPSYQGYILE---SAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
N + +F S +I + + P G + ++ + S + I D++ +
Sbjct: 691 NKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV-IFMNSTDLDTGFN 749
Query: 439 PELHLFL---NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GV-QESEPV 493
+L + N+ + +TG+ L +L P+DRE YT +IT +D G+ Q++
Sbjct: 750 GKLVYAVSGGNEDSCFMIDMETGM---LKILSPLDRETTDKYTLNITVYDLGIPQKAAWR 806
Query: 494 IVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ 553
++++ V+DANDN P F + SY V V D +IQ+ A D D G NG +TY I+
Sbjct: 807 LLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTD 866
Query: 554 GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQS 612
F I+ TG++ IA ++ + ++L ++A D A E TV ++V L N +
Sbjct: 867 -TFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA--REEPQLFSTVVVKVSLEDVNDN 923
Query: 613 PPRFPQLMYSLEISEAMRVGAVLLNLQATD---REGDSITYA-IENGDPQRVFNLSETTG 668
PP F Y +++ E + G V++ L+A D + + Y+ +++G+ F++ + +G
Sbjct: 924 PPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGN--FDVDKLSG 981
Query: 669 ILTLGKALDRESTDRYILIITASD-GRPDG-TSTATVNIVVTDVNDN--APVFDPYLPRN 724
+ + + LD E Y L + A D G+P +ST V + V DVN+N PVF ++ +
Sbjct: 982 AVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKG 1041
Query: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREV 781
+ + V V A D DA +G++ YS+ G+ +F+I G I T+ +L+RE
Sbjct: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRES 1101
Query: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
+Y L V ATD V P S + + I+V D++DN+P + Y + EN P +++QI
Sbjct: 1102 TSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQI 1161
Query: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL-RSLDYEAFPDQEASITFLVEA 898
EA D D +N + Y+I S + FF++HP TG ++ R LD E + +T
Sbjct: 1162 EAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN- 1220
Query: 899 FDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMV----APDAVKGT---PITTVYA 950
G+ P IA V V + D ND P F ++ YK + PD + P+ V A
Sbjct: 1221 ----GSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIA 1276
Query: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
D D P + + Y ++D F +E +G V ++ I L + A D
Sbjct: 1277 TDKDEG--PNAEISYSIEDGN---EHGKFFIEPKTGVVSSKRFSAAGEYDI--LSIKAVD 1329
Query: 1011 DGEPVMSSSATVKILVL---HPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSI 1067
+G P SS+ + I + P P +E + V E M+GVIS +
Sbjct: 1330 NGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPPGIPL 1389
Query: 1068 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSN 1126
+ I GN + F ++ TG I V PLD E +++Y L V+A D +L
Sbjct: 1390 WFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTTTIL---------- 1439
Query: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
+V+I++ D N+H P F Y + ED T +L++ A D+D N + +
Sbjct: 1440 -TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKNKLIYTLQSSRD 1498
Query: 1187 PIKEGKEGFVVETYTGLIKTA 1207
P+ K F ++ TG + T+
Sbjct: 1499 PLSLKK--FRLDPATGSLYTS 1517
Score = 258 bits (659), Expect = 3e-68
Identities = 318/1210 (26%), Positives = 514/1210 (42%), Gaps = 169/1210 (13%)
Query: 118 VQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 177
V+ + K +VR+ V D ND P F SY ++ E T + T+I AT
Sbjct: 120 VKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSI-----ARVSAT 174
Query: 178 DIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDR 237
D D G NG+ Y + D + T +G IVL RL+Y + Y + I A DR
Sbjct: 175 DADIGTNGEFYYSFKDRTDMFAIHPT-------SGVIVLTGRLDYLETKLYEMEILAADR 227
Query: 238 AQNL--NERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEEL 295
L + ++ LTV + ++ P+ L P+ D
Sbjct: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELD------------------R 269
Query: 296 NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE--LSLLEPV 353
+P + DQ N S SI+ G R P + E + + +
Sbjct: 270 DPAYAIVTVDDCDQGANGDIAS------LSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGI 323
Query: 354 NRDFHQ-KFDLVIKAEQDNGHPLPAFAG---LHIEILDENNQSPYFTMPSYQGYILESAP 409
+ D H ++L ++A +D G P P F+ +H+ F Y+ I E AP
Sbjct: 324 DWDSHPFGYNLTLQA-KDKGTP-PQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAP 381
Query: 410 VGATI--SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQ 467
+ ++ S LR V P F +Y T +++L+
Sbjct: 382 PNTPVVMVKAIPAYSHLRYVF-------KSTPGKAKFSLNYN----------TGLISILE 424
Query: 468 PVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS 527
PV R++ + +T D ++ V ++V+ AN N P F + +Y ++ G +
Sbjct: 425 PVKRQQAAHFELEVTTSDRKASTK---VLVKVLGANSNPPEFTQTAYKAAFDENVPIGTT 481
Query: 528 VIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGRTYALTVQAA 586
V+ L+AVD DEG NG +TY I F I+ TG ++ + ++ ++ R Y L ++A+
Sbjct: 482 VMSLSAVDPDEGENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS 541
Query: 587 DNAPPAERR-NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR-E 644
D P R + T+ + L N + P F ++ I + VG + + A D E
Sbjct: 542 DWGLPYRREVEVLATITLNNL---NDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE 598
Query: 645 GDSITYAIENGDPQRVFNLSETTGILTLGKALD---RESTDRYILIITASDGRPDGTSTA 701
+ Y IE G+ F+L+ +G+L+L ++L + L ITA+DG T
Sbjct: 599 LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT-PL 657
Query: 702 TVNIVVT-------------------------------------------DVNDNAPVFD 718
+NI V VN + P F
Sbjct: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
Query: 719 PYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTA 774
LP + V E + + V + +TD D G NG++ Y++ GN ++ F I G +
Sbjct: 718 STLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKIL 777
Query: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
L+RE D Y L + D + + + L + V+D +DN P F +Y V V E+
Sbjct: 778 SPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEV 837
Query: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
+ I+Q+EA D DLG N V+Y I + F++ TG +++ R LD E E S+
Sbjct: 838 HSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDSVTGVVNIARPLDREL--QHEHSL 893
Query: 893 TFLVEAFDIYGTMPPGIATVTVIV--KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
+EA D P +TV V V +D+ND PP F Y+ V D +GT I ++
Sbjct: 894 K--IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVI--MWL 949
Query: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
E DP + +VRY + D + F+V++ SG V L+ E ++ L V A D
Sbjct: 950 EAHDPDLGQSGQVRYSLLD----HGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKD 1005
Query: 1011 DGEPV-MSSSATVKILV------LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--- 1060
G+PV +SS+ V++ V LHP F ++ V E A G++V +SA
Sbjct: 1006 KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK----GTVKEDAPVGSLVMTVSAHDE 1061
Query: 1061 -AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
A + I YSI G+ F I TGVI + LD E+ + Y L V A VV
Sbjct: 1062 DARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVV---- 1117
Query: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
S+ ++YIE++D N++ P + Y + E++ SV++++A D D+ + +
Sbjct: 1118 ---PLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKL 1174
Query: 1180 AYRLIIPPIKEGKEGFV-VETYTGLI-KTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1237
Y++ +GF + TGLI T+ ++ +V TD+ S A
Sbjct: 1175 MYKI----TSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIAR 1230
Query: 1238 VLVSVVNQLD 1247
V+V ++++ D
Sbjct: 1231 VIVKILDEND 1240
Score = 258 bits (658), Expect = 4e-68
Identities = 259/949 (27%), Positives = 431/949 (45%), Gaps = 128/949 (13%)
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
F ++ T +S+LEPV R F+L + A + +++L N+ P FT
Sbjct: 411 FSLNYNTGLISILEPVKRQQAAHFELEVTTSDRK-----ASTKVLVKVLGANSNPPEFTQ 465
Query: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQT 457
+Y+ E+ P+G T+ + + A+D D E + N F +
Sbjct: 466 TAYKAAFDENVPIGTTV---------MSLSAVDPD-EGENGYVTYSIANLNHVPFAIDH- 514
Query: 458 GITRYLTLLQPVDREEQ-QTYTFSITAFDG---VQESEPVIVNIQVMDANDNTPTFPEIS 513
T ++ + +D E + YT I A D + V+ I + + NDNTP F +I+
Sbjct: 515 -FTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKIN 573
Query: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI-INKTTGLITIAPGVE 572
+ + D+ G+ + ++A+DADE + Y+I G + DF +N +G++++ +
Sbjct: 574 CEGTIPRDLGVGEQITTVSAIDADELQL--VQYQIEAGNELDFFSLNPNSGVLSLKRSLM 631
Query: 573 MIVGRT---YALTVQAADN---------------------------------------AP 590
+G ++L + A D A
Sbjct: 632 DGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQAN 691
Query: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDS 647
+ + ++ + N P L +++ E VG+ ++ + +TD +
Sbjct: 692 KLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGK 751
Query: 648 ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIV 706
+ YA+ G+ F + TG+L + LDRE+TD+Y L IT D G P + +++V
Sbjct: 752 LVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVV 811
Query: 707 VTDVNDNAPVF--DPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 763
V D NDN P F + Y + V E+ E ++ + QV+ATD D G NG V YS+ + F
Sbjct: 812 VVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDTF 868
Query: 764 RITS-NGSIYTAVKLNREVRDYYELVVVATDGA-VHPR-HSTLTLAIKVLDIDDNSPVFT 820
I S G + A L+RE++ + L + A D A P+ ST+ + + + D++DN P F
Sbjct: 869 SIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFI 928
Query: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKH---FFALHPFTGELSLL 877
Y V V E+LP GT I+ +EA D DLG S ++R + H F + +G + ++
Sbjct: 929 PPNYRVKVREDLPEGTVIMWLEAHDPDLGQ--SGQVRYSLLDHGEGNFDVDKLSGAVRIV 986
Query: 878 RSLDYEAFPDQEASITFLVEAFDIYGTMPPGIAT---VTVIVKDMND--YPPVFSKRIYK 932
+ LD+E ++ V A D P +++ V V V D+N+ +PPVFS + K
Sbjct: 987 QQLDFE----KKQVYNLTVRAKD--KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEK 1040
Query: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
G V DA G+ + TV A D D +RY + D +F++ E++G + T
Sbjct: 1041 GTVKEDAPVGSLVMTVSAHDED--ARRDGEIRYSIRDGS---GVGVFKIGEETGVIETSD 1095
Query: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
L+ E T+ + L V A D G +SS + I V + T E P + E + K
Sbjct: 1096 RLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKD 1155
Query: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRV 1107
V I A ++ N ++Y I SGN + F I+ TG+I LD E + ++
Sbjct: 1156 VSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHI--- 1212
Query: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE--------DARM 1159
LEV + + P KS A+V ++I DEN++ P F +KFY + E +AR
Sbjct: 1213 ----LEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
Query: 1160 FTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLIKT 1206
+ V ATDKD G + ++Y I++G E F +E TG++ +
Sbjct: 1269 -EPLYHVIATDKDEGPNAEISY-----SIEDGNEHGKFFIEPKTGVVSS 1311
Score = 249 bits (637), Expect = 1e-65
Identities = 281/1140 (24%), Positives = 487/1140 (42%), Gaps = 128/1140 (11%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V++ + D NDN PTF +Y V E P GT I A D D G +GQ+ Y +
Sbjct: 913 VKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMW-----LEAHDPDLGQSGQVRYSLL 967
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
+ + D L+G + + ++L++E K Y + ++A D+ + ++ ++T +
Sbjct: 968 DHGEGNFDVDK------LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVS--LSSTCYVE 1019
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
V+V+D ++ + P + + + + E+ + + A D+D
Sbjct: 1020 VEVVDVNE---------------NLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDAR 1064
Query: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
R G I YSI G+ F + T + + ++R+ + L + A
Sbjct: 1065 ------RDGEIRYSIRDGSGVGV---FKIGEETGVIETSDRLDRESTSHYWLTVFATDQG 1115
Query: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
PL +F ++IE+ D N+ +P + P Y I+E++P ++ ++I A D
Sbjct: 1116 VVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSV---------VQIEAFDP 1166
Query: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES 490
D + + F++ +TG+ T + +DRE+Q + +T D
Sbjct: 1167 DSSSNDKLMYKITSGNPQGFFSIHPKTGLIT--TTSRKLDREQQDEHILEVTVTDNGSPP 1224
Query: 491 EPVI--VNIQVMDANDNTPTFPEISYDVYVYTDMRPG-------DSVIQLTAVDADEGSN 541
+ I V ++++D NDN P F + Y + + +P + + + A D DEG N
Sbjct: 1225 KSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPN 1284
Query: 542 GEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
EI+Y I G + G F I TG+++ G L+++A DN P +++S
Sbjct: 1285 AEISYSIEDGNEHGKFFIEPKTGVVSSKRF--SAAGEYDILSIKAVDNGRP--QKSSTTR 1340
Query: 601 VYIEVL--PPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQ 658
++IE + P + P F + ++ + E+ V A ++ + + + G + + I G+
Sbjct: 1341 LHIEWISKPKPSLEPISFEESFFTFTVMESDPV-AHMIGVISVEPPGIPLWFDITGGNYD 1399
Query: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD 718
F++ + TG + + K LD E Y L + A+DG T V I V D ND+ P F
Sbjct: 1400 SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT--TILTQVFIKVIDTNDHRPQFS 1457
Query: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-----LFRIT-SNGSIY 772
+ + + Q+ A D D ++ Y+L + + FR+ + GS+Y
Sbjct: 1458 TSKYEVVIPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLY 1515
Query: 773 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 832
T+ KL+ E + L V+ D V + + + + V D +D++P FT S+Y V E+
Sbjct: 1516 TSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESA 1575
Query: 833 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 890
G+ +LQ+ A D D G N V Y I S + + F + P G + + LD +A
Sbjct: 1576 AVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELD----RSNQA 1631
Query: 891 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 950
+V+A D I +V + V ++ P F+ + Y ++ G+ + V A
Sbjct: 1632 EYDLMVKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA 1691
Query: 951 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
S V Y + D F++ SG +IT+ L+ E I+ L++
Sbjct: 1692 HS-------QSSVVYEIKDGN---TGDAFDINPHSGTIITQKALDFETLPIYTLII---- 1737
Query: 1011 DGEPVMSSSATVKILVLHPGE---IPRFTQEEYRPPPVSELATKGTMV-------GVISA 1060
G + S +LV E P F Q EY +SE A+ ++V VI A
Sbjct: 1738 QGTNMAGLSTNTTVLVHLQDENDNAPVFMQAEY-TGLISESASINSVVLTDRNVPLVIRA 1796
Query: 1061 AAI----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVL 1116
A N +VY IV + F I++ TG I+ LDYE + + VQ +
Sbjct: 1797 ADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPR 1856
Query: 1117 ANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNY 1176
A V + + D N+ PPVF K Y + V+ V ATD D+ +
Sbjct: 1857 L-----FAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAF 1911
Query: 1177 SVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLF---HNMRRSYFKFQVIATDDYGKGLS 1233
S + Y + EG + E ++ KT L RS ++ V A+D GL+
Sbjct: 1912 SQLIYSI--------TEGNIGEKFSMDYKTGALTVQNTTQLRSRYELTVRASDGRFAGLT 1963
Score = 243 bits (620), Expect = 1e-63
Identities = 289/1196 (24%), Positives = 498/1196 (41%), Gaps = 157/1196 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN--GATDIDDGPNGQIEYV 190
V + ++D NDN+P F Y ++E + + + T + A D D N + Y
Sbjct: 1751 VLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYH 1810
Query: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
I +P+ + F I TG I L+YE+ + + +Q +D
Sbjct: 1811 IV----EPSVHTYFAIDSS-TGAIHTVLSLDYEETSIFHFTVQVHDMGTP-RLFAEYAAN 1864
Query: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
+TV V+D +D P+F +PL Y+A+ L P ++T + A D D
Sbjct: 1865 VTVHVIDINDCPPVF-----------AKPL-YEAS---LLLPTYKGVKVIT--VNATDAD 1907
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
S ++YSI G + F M +T L++ +++L ++A
Sbjct: 1908 S-----SAFSQLIYSITEGNIGEK---FSMDYKTGALTVQNTTQ--LRSRYELTVRASDG 1957
Query: 371 NGHPLPAFAGL---HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
FAGL I + + FT Y + E++ T++ + +P+
Sbjct: 1958 R------FAGLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPIN-- 2009
Query: 428 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 487
+ +P+ ++ + V + T T P DRE+Q+ + +
Sbjct: 2010 --EPLFYHILNPDRRFKISRTSGVLSTTGT----------PFDREQQEAFDVVVEV---T 2054
Query: 488 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
+E +P V+V + V D NDN P F + Y V D G + +TAVD D G NG
Sbjct: 2055 EEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRNG 2114
Query: 543 EITYEIL-------VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERR 595
E+ Y + +G G+ + K L T+ + Y +TV A D PA
Sbjct: 2115 EVHYYLKEHHEHFQIGPLGEISLKKQFELDTL--------NKEYLVTVVAKDGGNPAFSA 2166
Query: 596 NSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENG 655
I + + N++ P F + YS EI+E+++V + ++++QA EG + Y+I +G
Sbjct: 2167 EVIVPITVM-----NKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPEGLKVFYSITDG 2221
Query: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
DP F ++ TG++ + LD E+ Y L I A+D + V+I+V D+NDN P
Sbjct: 2222 DPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFVDIIVDDINDNPP 2281
Query: 716 VFDPYLPRNLSVVEEEANAF---VGQVKATDPDAGINGQVHYSL-GNF---NNLFRITSN 768
VF ++ +V EA+ V QV+ATD D+ N + Y + GN ++ F + S+
Sbjct: 2282 VF---AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSS 2338
Query: 769 GSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 827
+ + ++ L+ E + + V A DG + S + + + V D++DN P+F Y
Sbjct: 2339 TGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEAR 2398
Query: 828 VEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
+ E+ P G + ++A D D + Y I S F + TG ++L +
Sbjct: 2399 ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALK 2458
Query: 886 PDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPI 945
P +++ F V V V N + P F + Y+ +A +A T +
Sbjct: 2459 PFYSLNLSVSDGVF-------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLV 2511
Query: 946 TTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFK 1003
V D D G+ + V+D + F + E G++ T L+ E +
Sbjct: 2512 MEVKTTDGD-SGIYGHVTYHIVND----FAKDRFYINE-RGQIFTLEKLDRETPAEKVIS 2565
Query: 1004 LVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA-- 1061
+ ++A D G V + V IL P+F +Y + A KGT V + A+
Sbjct: 2566 VRLMAKDAGGKVAFCTVNV-ILTDDNDNAPQFRATKYE-VNIGSSAAKGTSVVKVLASDA 2623
Query: 1062 --AINQSIVYSIVSGNE--EDTFGINNITGVIYVNGP---LDYETRTSYVLRVQADSLEV 1114
N I Y+I + +E ++ IN ++GVI L+ E T +V V S
Sbjct: 2624 DEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS--- 2680
Query: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
PSK + VY++I P F + FY VSED + T + ++A T
Sbjct: 2681 -------PSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTV 2733
Query: 1175 NYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIA---TDDYGKG 1231
YS++ P E FV++ +G +K + +++F ++A DD+
Sbjct: 2734 LYSLVKGN---TPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDDH--E 2788
Query: 1232 LSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE 1287
+ DV + V + D + + P + ++ E +PG V++
Sbjct: 2789 MVASVDVSIQVKDANDNSPVFESSP--------------YEAFIVENLPGGSRVIQ 2830
Score = 240 bits (613), Expect = 7e-63
Identities = 292/1154 (25%), Positives = 500/1154 (43%), Gaps = 140/1154 (12%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
E+ I V D NDN+P YY + E +P ++ A D D N ++ Y I
Sbjct: 1124 EIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV-----QIEAFDPDSSSNDKLMYKI 1178
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
+ + L+ T + ++L+ E + + + + D N + ++T +
Sbjct: 1179 TSGNPQGFFSIHPKTGLITTTS----RKLDREQQDEHILEVTVTD---NGSPPKSTIARV 1231
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
V +LD +D P FL Y+ +PE P+ P I D+
Sbjct: 1232 IVKILDENDNKPQFL------------QKFYKIRLPEREKPDRERNARREPLYHVIATDK 1279
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ--KFDLVIKAEQ 369
+ P ++ I YSI G ++ +FF + P+T +S ++ F ++D++
Sbjct: 1280 DEGPNAE---ISYSIEDG--NEHGKFF-IEPKTGVVS-----SKRFSAAGEYDILSIKAV 1328
Query: 370 DNGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVA 428
DNG P + LHIE + + PS + E + T+ +S + + +++
Sbjct: 1329 DNGRPQKSSTTRLHIEWISK-------PKPSLEPISFEESFFTFTVMESDPVAHMIGVIS 1381
Query: 429 LDKDIEDTKDPELHLFLN----DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAF 484
++ P + L+ + +Y S F V + T + + +P+D E++ Y ++ A
Sbjct: 1382 VE-------PPGIPLWFDITGGNYDSHFDVDKG--TGTIIVAKPLDAEQKSNYNLTVEAT 1432
Query: 485 DGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
DG + V I+V+D ND+ P F Y+V + D P ++Q++AVD DE ++
Sbjct: 1433 DGT-TTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDE--KNKL 1489
Query: 545 TYEILVG----AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
Y + + F ++ TG + + ++ + LTV D P +R +
Sbjct: 1490 IYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIV 1549
Query: 601 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP 657
V + N P F Y + E+ VG+V+L + A D++ + Y+IE+G+
Sbjct: 1550 VNVS---DTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNI 1606
Query: 658 QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV 716
F + G + K LDR + Y L++ A+D G P + +V I VT ++ +P
Sbjct: 1607 GNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADNASPK 1666
Query: 717 FDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT-SNGS 770
F + SV E +FVG V A V Y + GN + F I +G+
Sbjct: 1667 F---TSKEYSVELSETVSIGSFVGMVTAHS-----QSSVVYEIKDGNTGDAFDINPHSGT 1718
Query: 771 IYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEE 830
I T L+ E Y L++ T+ A + T+ + + D +DN+PVF + YT L+ E
Sbjct: 1719 IITQKALDFETLPIYTLIIQGTNMA--GLSTNTTVLVHLQDENDNAPVFMQAEYTGLISE 1776
Query: 831 NLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
+ + +L I A D D +N + Y I P V +FA+ TG + + SLD
Sbjct: 1777 SASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLD 1836
Query: 882 YEAFPDQEASITFLVEAFDIYGT---MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPD 938
YE + + F V+ D+ GT A VTV V D+ND PPVF+K +Y+ +
Sbjct: 1837 YE----ETSIFHFTVQVHDM-GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLP 1891
Query: 939 AVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEP 998
KG + TV A DAD S++ Y + + F ++ +G + V +
Sbjct: 1892 TYKGVKVITVNATDADSSAF--SQLIYSITEGNI---GEKFSMDYKTGAL--TVQNTTQL 1944
Query: 999 TTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGV 1057
+ ++L V A D + +VKI V E +FTQ+ Y V E +T+ + V
Sbjct: 1945 RSRYELTVRASDGR---FAGLTSVKINVKESKESHLKFTQDVY-SAVVKENSTEAETLAV 2000
Query: 1058 ISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEV 1114
I+A IN+ + Y I+ N + F I+ +GV+ G P D R Q ++ +V
Sbjct: 2001 ITAIGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFD---------REQQEAFDV 2049
Query: 1115 VLANLRVPSKSNTAKVYIE--IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
V+ S A V ++ ++D+N++ PVF Y V D + + V A D+D
Sbjct: 2050 VVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRD 2109
Query: 1173 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGL-IKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
+G + Y L KE E F + + +K + + Y V+A D
Sbjct: 2110 SGRNGEVHYYL-----KEHHEHFQIGPLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPA 2163
Query: 1232 LSGKADVLVSVVNQ 1245
S + V ++V+N+
Sbjct: 2164 FSAEVIVPITVMNK 2177
Score = 219 bits (557), Expect = 2e-56
Identities = 281/1199 (23%), Positives = 500/1199 (41%), Gaps = 125/1199 (10%)
Query: 111 IHSIVVQVQCINKKVG--TIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
++++ V+ + K V + Y EV +V + N + P F TV E PVG+ + T
Sbjct: 996 VYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMT 1055
Query: 169 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRY 228
A D D +G+I Y I+ D + F+I TG I RL+ E + Y
Sbjct: 1056 -----VSAHDEDARRDGEIRYSIR----DGSGVGVFKIG-EETGVIETSDRLDRESTSHY 1105
Query: 229 FVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPE 288
++ + A D+ ++ + ++V D +D P V P +
Sbjct: 1106 WLTVFATDQGV---VPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIME------------ 1150
Query: 289 LRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELS 348
+P++++ + I+A D D S ++Y I G P+ FF +HP+T ++
Sbjct: 1151 -NSPKDVSVV----QIEAFDPD-----SSSNDKLMYKITSGNPQG---FFSIHPKTGLIT 1197
Query: 349 LL-EPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILES 407
++R+ + L + + P A + ++ILDEN+ P F Y+ + E
Sbjct: 1198 TTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER 1257
Query: 408 APVGATISDSLNLTSPL-RIVALDKDIEDTKDPELHLFL---NDYTSVFTVTQTGITRYL 463
+ PL ++A DKD + + E+ + N++ F +TG+
Sbjct: 1258 EKPD---RERNARREPLYHVIATDKD--EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSK 1312
Query: 464 TLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT-DM 522
+ + SI A D + + + + + P+ IS++ +T +
Sbjct: 1313 RFSAAGEYD-----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTV 1367
Query: 523 RPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYAL 581
D V + V + E + ++I G F ++K TG I +A ++ Y L
Sbjct: 1368 MESDPVAHMIGVISVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNL 1427
Query: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
TV+A D + V+I+V+ N+ P+F Y + I E +L + A
Sbjct: 1428 TVEATDGT-----TTILTQVFIKVIDTNDHR-PQFSTSKYEVVIPEDTAPETEILQISAV 1481
Query: 642 DR-EGDSITYAIENG-DP--QRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPD 696
D+ E + + Y +++ DP + F L TG L + LD E+ ++ L + D P
Sbjct: 1482 DQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPV 1541
Query: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
+ A + + V+D ND+AP F + + V QV A D D G N +V YS+
Sbjct: 1542 KRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSI 1601
Query: 757 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 813
GN N F I GSI TA +L+R + Y+L+V ATD P ++ I V D
Sbjct: 1602 ESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIAD 1661
Query: 814 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 873
+ SP FT+ Y+V + E + G+ + + A ++V Y I+ F ++P +G
Sbjct: 1662 NASPKFTSKEYSVELSETVSIGSFVGMVTAHS---QSSVVYEIKDGNTGDAFDINPHSGT 1718
Query: 874 LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI---VKDMNDYPPVFSKRI 930
+ ++LD+E P + I GT G++T T + ++D ND PVF +
Sbjct: 1719 IITQKALDFETLP---------IYTLIIQGTNMAGLSTNTTVLVHLQDENDNAPVFMQAE 1769
Query: 931 YKGMVAPDAVKGTPITT-------VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEE 983
Y G+++ A + + T + A DAD A V + V+ P + F ++
Sbjct: 1770 YTGLISESASINSVVLTDRNVPLVIRAADADKDS-NALLVYHIVE----PSVHTYFAIDS 1824
Query: 984 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSS--SATVKILVLHPGEIPRFTQEEYR 1041
+G + T ++L+ E T+IF V D G P + + +A V + V+ + P +
Sbjct: 1825 STGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLY 1884
Query: 1042 PPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1097
+ KG V ++A + S ++YSI GN + F ++ TG + V
Sbjct: 1885 EASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTT-- 1942
Query: 1098 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA 1157
+ R+ Y L V+A + V I +++ F + Y V E++
Sbjct: 1943 QLRSRYELTVRASDGRF----------AGLTSVKINVKESKESHLKFTQDVYSAVVKENS 1992
Query: 1158 RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK-TAMLFHNMRRS 1216
++ + A + Y ++ P + F + +G++ T F ++
Sbjct: 1993 TEAETLAVITAIGNPIN--EPLFYHILNPDRR-----FKISRTSGVLSTTGTPFDREQQE 2045
Query: 1217 YFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYV 1275
F V T+++ V V V +Q D + N+P V K ++ ++ RYV
Sbjct: 2046 AFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVI-RYV 2103
Score = 216 bits (549), Expect = 2e-55
Identities = 288/1127 (25%), Positives = 480/1127 (42%), Gaps = 127/1127 (11%)
Query: 156 VNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIV 215
V E PVG+++ +TD+D G NG++ Y + +D F I M TG +
Sbjct: 726 VKENQPVGSSVIF-----MNSTDLDTGFNGKLVYAVSGGNED----SCFMID-METGMLK 775
Query: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTR 275
+ L+ E +Y + I D ++ L V V+D +D P FL
Sbjct: 776 ILSPLDRETTDKYTLNITVYDLG---IPQKAAWRLLHVVVVDANDNPPEFL--------- 823
Query: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
++ E+ +E++ I+ ++A D+D P+ + YSI+ T
Sbjct: 824 ------QESYFVEVSEDKEVHSEII--QVEATDKDLG---PNGH--VTYSIVTDTDT--- 867
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEIL--DENNQSP 393
F + T +++ P++R+ + L I+A F+ + +++ D N+ P
Sbjct: 868 --FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPP 925
Query: 394 YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFT 453
F P+Y+ + E P G I + + A D D+ + L L+ F
Sbjct: 926 TFIPPNYRVKVREDLPEGTVI---------MWLEAHDPDLGQSGQVRYSL-LDHGEGNFD 975
Query: 454 VTQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDN--TPT 508
V + ++ + ++Q +D E++Q Y ++ A D V S V ++V+D N+N P
Sbjct: 976 VDK--LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPV 1033
Query: 509 FPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA-QGDFIINKTTGLITI 567
F V D G V+ ++A D D +GEI Y I G+ G F I + TG+I
Sbjct: 1034 FSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIET 1093
Query: 568 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 627
+ ++ Y LTV A D +S +YIEV N+ + P+ + +Y EI E
Sbjct: 1094 SDRLDRESTSHYWLTVFATDQG--VVPLSSFIEIYIEVEDVNDNA-PQTSEPVYYPEIME 1150
Query: 628 AMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGIL-TLGKALDRESTDR 683
++ ++A D + D + Y I +G+PQ F++ TG++ T + LDRE D
Sbjct: 1151 NSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDE 1210
Query: 684 YILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-----DPYLPRNLSVVEEEANAF-- 735
+IL +T +D G P ++ A V + + D NDN P F LP + E NA
Sbjct: 1211 HILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPER-EKPDRERNARRE 1269
Query: 736 -VGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVAT 792
+ V ATD D G N ++ YS+ GN + F I + ++ + + +Y L + A
Sbjct: 1270 PLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFS-AAGEYDILSIKAV 1328
Query: 793 DGAVHPRHSTLTLAIKVLDIDDNS--PV-FTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
D + ST L I+ + S P+ F S +T V E+ P I I + G
Sbjct: 1329 DNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVISVEPP--G 1386
Query: 850 ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909
+ + I F + TG + + + LD E Q+++ VEA D T+ +
Sbjct: 1387 IPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAE----QKSNYNLTVEATDGTTTI---L 1439
Query: 910 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 969
V + V D ND+ P FS Y+ ++ D T I + A D D +++ Y +
Sbjct: 1440 TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQD----EKNKLIYTLQS 1495
Query: 970 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
+ P F ++ +G + T L+ E L V+ D PV + A + + V
Sbjct: 1496 SRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDT 1555
Query: 1030 GE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINN 1084
+ P FT Y+ V E A G++V ++A N ++YSI SGN ++F I+
Sbjct: 1556 NDHAPWFTASSYK-GRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP 1614
Query: 1085 ITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVF 1144
+ G I LD + Y L V+A + P S V I + +N P F
Sbjct: 1615 VLGSIKTAKELDRSNQAEYDLMVKA-------TDKGSPPMSEITSVRIFVTIADNASPKF 1667
Query: 1145 QKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG--FVVETYTG 1202
K Y +SE + + V V A + + ++ IK+G G F + ++G
Sbjct: 1668 TSKEYSVELSETVSIGSFVGMVTAHSQSS----------VVYEIKDGNTGDAFDINPHSG 1717
Query: 1203 LIKT--AMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
I T A+ F + + +I GLS VLV + ++ D
Sbjct: 1718 TIITQKALDFETLP----IYTLIIQGTNMAGLSTNTTVLVHLQDEND 1760
Score = 179 bits (453), Expect = 3e-44
Identities = 234/946 (24%), Positives = 393/946 (41%), Gaps = 142/946 (15%)
Query: 410 VGATISDSLNLTSP---LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLL 466
VG + + +T P +R + D E+ E ++ L D+ + T+ G T L
Sbjct: 53 VGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYI-LGDFCFLRIRTKGGNTAIL--- 108
Query: 467 QPVDREEQQTYTFSITAFDGVQESEP-VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPG 525
+RE + YT + A + E V +QV+D ND P F SY V + +
Sbjct: 109 ---NREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
Query: 526 DSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
S+ +++A DAD G+NGE Y F I+ T+G+I + ++ + + Y + + A
Sbjct: 166 TSIARVSATDADIGTNGEFYYSFK-DRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILA 224
Query: 586 ADNAPPAERRNSIC-----TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA 640
AD + I TV+IE N +P + E+ V ++
Sbjct: 225 ADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSELDRDPAYAIVTVDDCD 282
Query: 641 TDREGDSITYAIENGD------PQRVFNLSETTGILTLGKALDRESTD-RYILIITASD- 692
GD + +I GD R F S+ + +G +D +S Y L + A D
Sbjct: 283 QGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIG-GIDWDSHPFGYNLTLQAKDK 341
Query: 693 GRPDGTSTATVNIVVTDVNDNAPV----------FDPYLPRNLSVVEEEANAFVGQVKAT 742
G P S+ V V + PV + P N VV +A ++
Sbjct: 342 GTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMVKAIPAYSHLRYV 401
Query: 743 DPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 802
G+ +SL N+N G I + R+ ++EL V +D R ++
Sbjct: 402 FKSTP--GKAKFSL-NYNT-------GLISILEPVKRQQAAHFELEVTTSD-----RKAS 446
Query: 803 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 860
+ +KVL + N P FT + Y +EN+P GTT++ + A D D G N V+Y I +
Sbjct: 447 TKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIAN-- 504
Query: 861 VKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI---YGTMPPGIATVTVIV 916
+ H FA+ FTG +S +LDYE P T + A D Y +AT+T+
Sbjct: 505 LNHVPFAIDHFTGAVSTSENLDYELMP---RVYTLRIRASDWGLPYRREVEVLATITL-- 559
Query: 917 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 976
++ND P+F K +G + D G ITTV A DAD L V+Y+++
Sbjct: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQL----VQYQIEAGN---EL 612
Query: 977 SIFEVEEDSGRV--------------------ITRVNLNEEPTTIFKLVVVAF------- 1009
F + +SG + IT + T ++ + VA
Sbjct: 613 DFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNL 672
Query: 1010 ---DDGEPVMSSSATVKILVLH-PGE--------------IPRFTQEEYRPPPVSELATK 1051
+ G M + ++ LH GE IP+F V E
Sbjct: 673 QCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPV 732
Query: 1052 GTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
G+ V +++ N +VY++ GNE+ F I+ TG++ + PLD ET Y
Sbjct: 733 GSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKY---- 788
Query: 1108 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
+L + + +L +P K+ +++ + D N++PP F ++ Y VSED + + +++V+
Sbjct: 789 ---TLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVE 845
Query: 1168 ATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1227
ATDKD G + Y ++ + F +++ TG++ A + ++ A D
Sbjct: 846 ATDKDLGPNGHVTYSIV-----TDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQ 900
Query: 1228 YGKGLSGKADVLVSVVNQLDMQVIVSN----VPPTLVEKKIEDLTE 1269
+ + + +VV ++ ++ + N +PP K EDL E
Sbjct: 901 ARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPE 942
Score = 170 bits (431), Expect = 9e-42
Identities = 185/683 (27%), Positives = 293/683 (42%), Gaps = 93/683 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI- 191
V + V D NDNSP + Y T+ E G I ATD D N +I Y +
Sbjct: 3009 VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIM-----QISATDADIRSNAEITYTLL 3063
Query: 192 -------QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
+ NPD TG + L+ E++ Y ++++A D
Sbjct: 3064 GSGAEKFKLNPD--------------TGELKTSTPLDREEQAVYHLLVRATDGGG----- 3104
Query: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP-EELNPIIVTPP 303
R ++ + + D +D P F +A P T E P +
Sbjct: 3105 RFCQASIVLTLEDVNDNAPEF------------------SADPYAITVFENTEPGTLLTR 3146
Query: 304 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 363
+QA D D + ILYS++ F ++ + + L +P++R+ + L
Sbjct: 3147 VQATDADAGLNRK-----ILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQAVYTL 3197
Query: 364 VIKAEQDNGHP--LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNL- 420
+KA D G P L A + + +LD N+ P F Y GAT+S+ + +
Sbjct: 3198 SLKAV-DQGLPRRLTATGTVIVSVLDINDNPPVFEYREY----------GATVSEDILVG 3246
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
T L++ A +DIE + + + F++ T + +++ +D E Y +
Sbjct: 3247 TEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSK--TGAVFIIENLDYESSHEYYLT 3304
Query: 481 ITAFDGVQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADE 538
+ A DG S + VN+ V D NDNTP F + +Y + D SVI + A DAD
Sbjct: 3305 VEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADG 3364
Query: 539 GSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
SN I Y I+ G QG F I+ G + + ++ Y LTVQA+DN P R +
Sbjct: 3365 PSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPP--RVN 3422
Query: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE----GDSITYAIE 653
TV I+V N+ +P F + YS+ I E VG +L L TD + G + I
Sbjct: 3423 TTTVNIDVSDVNDNAPV-FSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
Query: 654 NGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVND 712
G+ ++ F ++ G+L A+ R+ D Y+L + +D G+P +S ++I V + +
Sbjct: 3482 TGNDEKAFEVNPQ-GVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESI 3540
Query: 713 NAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNGSI 771
P P S EE + +G++ ATD D + + YSL +NLF ++S G
Sbjct: 3541 YPPAILPLEIFITSSGEEYSGGVIGKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGK 3598
Query: 772 YTAVKLNREVRDYYELVVVATDG 794
A K ++ Y L V TDG
Sbjct: 3599 LIAHK-KLDIGQYL-LNVSVTDG 3619
Score = 142 bits (359), Expect = 2e-33
Identities = 149/586 (25%), Positives = 253/586 (43%), Gaps = 64/586 (10%)
Query: 126 GTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNG 185
G + + + D NDN+P F + Y TV E T GT + ATD D G N
Sbjct: 3104 GRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTR-----VQATDADAGLNR 3158
Query: 186 QIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
+I Y + + D S + L+G I L K L+ E + Y + ++A D Q L R
Sbjct: 3159 KILYSLIDSADGQFSINE------LSGIIQLEKPLDRELQAVYTLSLKAVD--QGLPRRL 3210
Query: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
T T T+ V VLD +D P+F Y A + E + ++ T +Q
Sbjct: 3211 TATGTVIVSVLDINDNPPVF------------EYREYGATVSE-------DILVGTEVLQ 3251
Query: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVI 365
R+I+ ++ I YSI+ G F + +T + ++E ++ + ++ L +
Sbjct: 3252 VYAASRDIEANAE---ITYSIISGNEHGK---FSIDSKTGAVFIIENLDYESSHEYYLTV 3305
Query: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
+A L A +++ + D N+ +P F+ +Y I E A + ++
Sbjct: 3306 EATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSV----------- 3354
Query: 426 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485
I + D + + +H + D + T + + + + +DRE YT ++ A D
Sbjct: 3355 ITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASD 3414
Query: 486 --GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG- 542
VNI V D NDN P F +Y V + + G SV+QL D D NG
Sbjct: 3415 NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGP 3474
Query: 543 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVY 602
+ I+ G G++ + ++ Y L V+ ADN P + +S+ +
Sbjct: 3475 PFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKP--QLSSLTYID 3532
Query: 603 IEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ--R 659
I V+ + P P ++ E G V+ + ATD++ D++TY++ DPQ
Sbjct: 3533 IRVIEESIYPPAILPLEIFITSSGEEYS-GGVIGKIHATDQDVYDTLTYSL---DPQMDN 3588
Query: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI 705
+F++S T G L K LD +Y+L ++ +DG+ + TV+I
Sbjct: 3589 LFSVSSTGGKLIAHKKLD---IGQYLLNVSVTDGKFTTVADITVHI 3631
Score = 129 bits (324), Expect = 2e-29
Identities = 141/553 (25%), Positives = 246/553 (44%), Gaps = 55/553 (9%)
Query: 353 VNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGA 412
+NR+ + L++KA + N + + A + +++LD N+ P F+ SY + E+ +
Sbjct: 108 LNREVKDHYTLIVKALEKNTN-VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRT 166
Query: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
+I+ R+ A D DI + E + D T +F + T + + L +D
Sbjct: 167 SIA---------RVSATDADIGT--NGEFYYSFKDRTDMFAIHPT--SGVIVLTGRLDYL 213
Query: 473 EQQTYTFSITAFD---------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMR 523
E + Y I A D G+ + V+I+ AN+ P ++ D
Sbjct: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIE--QANECAPVITAVTLSPSEL-DRD 270
Query: 524 PGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG-----VEMIVGRT 578
P +++ T D D+G+NG+I +V GD + T + PG V+ I G
Sbjct: 271 PAYAIV--TVDDCDQGANGDIASLSIVA--GDLLQQFRT--VRSFPGSKEYKVKAIGGID 324
Query: 579 -------YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRV 631
Y LT+QA D P + +S+ +++ P P +F + +Y EISE
Sbjct: 325 WDSHPFGYNLTLQAKDKGTPPQF-SSVKVIHV-TSPQFKAGPVKFEKDVYRAEISEFAPP 382
Query: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
++ ++A + Y ++ + F+L+ TG++++ + + R+ + L +T S
Sbjct: 383 NTPVVMVKAIPAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
Query: 692 DGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQ 751
D + ++ V + V N N P F + V + A DPD G NG
Sbjct: 442 DRK----ASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGY 497
Query: 752 VHYSLGNFNNL-FRITS-NGSIYTAVKLNREVRD-YYELVVVATDGAVHPRHSTLTLA-I 807
V YS+ N N++ F I G++ T+ L+ E+ Y L + A+D + R LA I
Sbjct: 498 VTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATI 557
Query: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFAL 867
+ +++DN+P+F + +L G I + A D D V Y+I + FF+L
Sbjct: 558 TLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSL 617
Query: 868 HPFTGELSLLRSL 880
+P +G LSL RSL
Sbjct: 618 NPNSGVLSLKRSL 630
Score = 103 bits (256), Expect = 2e-21
Identities = 166/705 (23%), Positives = 291/705 (41%), Gaps = 94/705 (13%)
Query: 611 QSPPRFPQLMYSLEISEAMRVGA-----VLLNLQATDREGDSITYAIENGDPQRVFNLSE 665
Q+P +F L Y++ + E V + + T + + Y I +GD + +F E
Sbjct: 29 QTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWE-VRYKIVSGDSENLFKAEE 87
Query: 666 TT-------GILTLG---KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAP 715
I T G L+RE D Y LI+ A + + + V + V D ND P
Sbjct: 88 YILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRP 147
Query: 716 VFDPY-----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI-TSNG 769
+F P LP N ++ + +V ATD D G NG+ +YS + ++F I ++G
Sbjct: 148 LFSPTSYSVSLPENTAI-----RTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSG 202
Query: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHST-----LTLAIKVLDIDDNSPVFTNSTY 824
I +L+ YE+ ++A D + S+ L + + ++ +PV T T
Sbjct: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTL 262
Query: 825 TVLVEENLPAGTTILQIEAKDVDLGANVSYR----IRSPEVKHFFALHPFTG----ELSL 876
+ + PA + D D GAN + ++ F + F G ++
Sbjct: 263 SPSELDRDPAYAIVT---VDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKA 319
Query: 877 LRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDY---PPVFSKRIYKG 933
+ +D+++ P ++A D GT PP ++V VI + P F K +Y+
Sbjct: 320 IGGIDWDSHP---FGYNLTLQAKD-KGT-PPQFSSVKVIHVTSPQFKAGPVKFEKDVYRA 374
Query: 934 MVAPDAVKGTPITTVYAEDADPPGLPA-SRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
++ A TP+ V A +PA S +RY P A F + ++G +
Sbjct: 375 EISEFAPPNTPVVMVKA-------IPAYSHLRYVFKST--PGKAK-FSLNYNTGLISILE 424
Query: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKG 1052
+ + F+L V D S+ VK+L + P FTQ Y+ E G
Sbjct: 425 PVKRQQAAHFELEVTTSDRKA---STKVLVKVLGANSNP-PEFTQTAYKAA-FDENVPIG 479
Query: 1053 TMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS-YVLRV 1107
T V +SA N + YSI + N F I++ TG + + LDYE Y LR+
Sbjct: 480 TTVMSLSAVDPDEGENGYVTYSIANLNHVP-FAIDHFTGAVSTSENLDYELMPRVYTLRI 538
Query: 1108 QADSLEVVLANLRVPSKSNTAKVY-IEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
+A ++ +P + + I + + N++ P+F+K G + D + + V
Sbjct: 539 RA-------SDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTV 591
Query: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVETYTGLI---KTAMLFHNMRRSYFKFQ 1221
A D D +L+ I+ G E F + +G++ ++ M + S+ +
Sbjct: 592 SAIDAD-------ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLR 644
Query: 1222 VIATDDYGKGLSGKADVLVSVVNQL-DMQVIVSNVPPTLVEKKIE 1265
+ ATD ++ V+ ++L ++Q + V L EK ++
Sbjct: 645 ITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQ 689
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 293 bits (750), Expect = 1e-78
Identities = 277/983 (28%), Positives = 454/983 (46%), Gaps = 88/983 (8%)
Query: 138 RDRNDNS-PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
R RN N+ P F+ SY ATV E P GT + A D D+G G++EY +
Sbjct: 171 RKRNVNTAPQFQPPSYQATVPENQPAGTPV-----ASLRAIDPDEGEAGRLEYTMD-ALF 224
Query: 197 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
D SN F + +TG + + L+ E K+ + + A D RR+ TLT+ V
Sbjct: 225 DSRSNQFFSLD-PVTGAVTTAEELDRETKSTHVFRVTAQDHGM---PRRSALATLTILVT 280
Query: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
D +D P+F Q LR E+ ++T ++A D D PP
Sbjct: 281 DTNDHDPVF---------------EQQEYKESLRENLEVGYEVLT--VRATDGD---APP 320
Query: 317 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
+ ILY +L G+ F + PR+ + PV+R+ + + L ++A P P
Sbjct: 321 N--ANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGP 378
Query: 377 --AFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
A + + + D+N+ +P F+ Y + E GA + LR+ A D+D
Sbjct: 379 RSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV---------LRVTASDRDKG 429
Query: 435 DTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ES 490
+ + F + QTG L ++ P+D E + YT + A DG + +
Sbjct: 430 SNAVVHYSIMSGNARGQFYLDAQTGA---LDVVSPLDYETTKEYTLRVRAQDGGRPPLSN 486
Query: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL- 549
+V +QV+D NDN P F + V + G V+ + A+DAD G N + Y +
Sbjct: 487 VSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG 546
Query: 550 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
VG F IN TG I++A ++ Y+ V+A D+ PA ++ +V + + N
Sbjct: 547 VGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDN 606
Query: 610 NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSETT- 667
N P F Q Y++ ++E VG ++ + A DR+ S ITY I +G+ + F+++ +
Sbjct: 607 N---PTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSG 663
Query: 668 -GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 725
G+++L LD + +Y+L +TASDG T+ VN VTD N + PVF + N+
Sbjct: 664 GGLVSLALPLDYKLERQYVLAVTASDGTRQDTAQIVVN--VTDANTHRPVFQSSHYTVNV 721
Query: 726 SVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDY 784
+ + A V + ATD D G N ++ Y + + FRI ++ G++ T +L+ E +
Sbjct: 722 N-EDRPAGTTVVLISATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVS 780
Query: 785 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 844
Y L + A D + + T L I V D++DN+P F +Y V E++P T++LQI A
Sbjct: 781 YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISAT 840
Query: 845 DVDLGAN--VSYRIR-SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901
D D G N V Y + + F + +G + LR L D+E +++ A+ +
Sbjct: 841 DRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL------DRENVAQYVLRAYAV 894
Query: 902 YGTMPPGIA--TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959
MPP VTV V D+ND PPVF + + V ++ G + V A D D
Sbjct: 895 DKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEG--T 952
Query: 960 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019
+++ Y++ + P +F+++ SG + V+L+ E + LV+ A P++ S
Sbjct: 953 NAQIMYQIVEGNIP---EVFQLDIFSGELTALVDLDYEDRPEYVLVIQA--TSAPLV-SR 1006
Query: 1020 ATVKILVL----HPGEIPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSIVS 1073
ATV + +L +P + F + G +G + A I+ S+ YS
Sbjct: 1007 ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER 1066
Query: 1074 GNEEDTFGINNITGVIYVNGPLD 1096
GNE +N TG + ++ LD
Sbjct: 1067 GNELSLVLLNASTGELKLSRALD 1089
Score = 292 bits (747), Expect = 2e-78
Identities = 254/894 (28%), Positives = 421/894 (47%), Gaps = 73/894 (8%)
Query: 390 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD------IEDTKDPELHL 443
N +P F PSYQ + E+ P G ++ + A+D D +E T D
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVAS---------LRAIDPDEGEAGRLEYTMDALFDS 226
Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 501
N + S+ VT +T + +DRE + T+ F +TA D + S + I V D
Sbjct: 227 RSNQFFSLDPVTGA-----VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTD 281
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557
ND+ P F + Y + ++ G V+ + A D D N I Y +L G+ G F
Sbjct: 282 TNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFE 341
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
I+ +G+I V+ +Y LTV+A+D R++ V++ V +N + P+F
Sbjct: 342 IDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSV-EDDNDNAPQFS 400
Query: 618 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674
+ Y +++ E + GA +L + A+DR+ S + Y+I +G+ + F L TG L +
Sbjct: 401 EKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVS 460
Query: 675 ALDRESTDRYILIITASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
LD E+T Y L + A DG P + V + V D+NDNAP+F P +V+E
Sbjct: 461 PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS-TPFQATVLESVP 519
Query: 733 NAF-VGQVKATDPDAGINGQVHYSLGNFNNLFRITSN---GSIYTAVKLNREVRDYYELV 788
+ V V+A D DAG N ++ Y L + F T N G I A +L+RE D+Y
Sbjct: 520 LGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFG 579
Query: 789 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
V A D ++ ++++ VLD++DN+P FT YTV + E+ GT+++ + A D D
Sbjct: 580 VEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA 639
Query: 849 GANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
+ ++Y+I S ++ F++ +G +SL LDY+ E V A D GT
Sbjct: 640 HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKL----ERQYVLAVTASD--GTR- 692
Query: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
A + V V D N + PVF Y V D GT + + A D D +R+ Y
Sbjct: 693 QDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTG--ENARITYF 750
Query: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILV 1026
++D P F ++ D+G V T+ L+ E + L + A D+G P S + ++ILV
Sbjct: 751 MED-SIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILV 805
Query: 1027 LHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED-TF 1080
+ P+F ++ Y+ V E T V ISA + +N + Y+ G++ D F
Sbjct: 806 NDVNDNAPQFLRDSYQ-GSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDF 864
Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
+ + +G++ LD E YVLR A + +P +V + + D N++
Sbjct: 865 IVESTSGIVRTLRRLDRENVAQYVLRAYA-------VDKGMPPARTPMEVTVTVLDVNDN 917
Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
PPVF++ + V E++ + +V RV ATD D G + + Y+++ I E F ++ +
Sbjct: 918 PPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNI---PEVFQLDIF 974
Query: 1201 TGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
+G + + R + + AT L +A V V ++++ D ++ N
Sbjct: 975 SGELTALVDLDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN 1025
Score = 285 bits (730), Expect = 2e-76
Identities = 262/918 (28%), Positives = 421/918 (45%), Gaps = 109/918 (11%)
Query: 39 PPATIVAIDEESRNGTILVDNMLI---KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLF 95
PP+ + E GT + I +G AG + T++ + + +DPV +
Sbjct: 183 PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAV- 241
Query: 96 LNSTGRVLDRDPPM-NIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYA 154
+T LDR+ ++ + Q + ++ + I+V D ND+ P F+ + Y
Sbjct: 242 --TTAEELDRETKSTHVFRVTAQDHGMPRRSALAT---LTILVTDTNDHDPVFEQQEYKE 296
Query: 155 TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VIQYNPDDPTSNDTFEIPLMLTGN 213
++ E VG + T ATD D PN I Y +++ + P ++ FEI +G
Sbjct: 297 SLRENLEVGYEVLT-----VRATDGDAPPNANILYRLLEGSGGSP--SEVFEID-PRSGV 348
Query: 214 IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273
I R ++ E+ Y + ++A+D+ ++ R+TT + + V D +D P F V
Sbjct: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGP-RSTTAAVFLSVEDDNDNAPQFSEKRYVVQ 407
Query: 274 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 333
R E++ P + A D+D+ + YSI+ G
Sbjct: 408 VR-----------------EDVTPGAPVLRVTASDRDK-----GSNAVVHYSIMSGNARG 445
Query: 334 YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQS 392
F++ +T L ++ P++ + +++ L ++A+ PL +GL +++LD N+ +
Sbjct: 446 Q---FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNA 502
Query: 393 PYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVF 452
P F +Q +LES P+G + L + A+D D D E L + F
Sbjct: 503 PIFVSTPFQATVLESVPLGYLV---------LHVQAIDADAGDNARLEYRLAGVGHDFPF 553
Query: 453 TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI-----VNIQVMDANDNTP 507
T+ T ++++ +DREE Y+F + A D P + V++ V+D NDN P
Sbjct: 554 TINNG--TGWISVAAELDREEVDFYSFGVEARD---HGTPALTASASVSVTVLDVNDNNP 608
Query: 508 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTT--GL 564
TF + Y V + D G SV+ ++AVD D ++ ITY+I G + F I + GL
Sbjct: 609 TFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--AHSVITYQITSGNTRNRFSITSQSGGGL 666
Query: 565 ITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLE 624
+++A ++ + R Y L V A+D R + + V N P F Y++
Sbjct: 667 VSLALPLDYKLERQYVLAVTASDGT-----RQDTAQIVVNVTDANTHRPV-FQSSHYTVN 720
Query: 625 ISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDREST 681
++E G ++ + ATD E ITY +E+ PQ F + TG +T LD E
Sbjct: 721 VNEDRPAGTTVVLISATDEDTGENARITYFMEDSIPQ--FRIDADTGAVTTQAELDYEDQ 778
Query: 682 DRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAF--V 736
Y L ITA D G P + T + I+V DVNDNAP F D Y V E+ F V
Sbjct: 779 VSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSY----QGSVYEDVPPFTSV 834
Query: 737 GQVKATDPDAGINGQVHYSL-----GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791
Q+ ATD D+G+NG+V Y+ G+ + + TS G + T +L+RE Y L A
Sbjct: 835 LQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTS-GIVRTLRRLDRENVAQYVLRAYA 893
Query: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN 851
D + P + + + + VLD++DN PVF + V VEEN P G + ++ A D D G N
Sbjct: 894 VDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTN 953
Query: 852 --VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI 909
+ Y+I + F L F+GEL+ L LDYE P+ I T P +
Sbjct: 954 AQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEY---------VLVIQATSAPLV 1004
Query: 910 ATVTVIVK--DMNDYPPV 925
+ TV V+ D ND PPV
Sbjct: 1005 SRATVHVRLLDRNDNPPV 1022
Score = 283 bits (724), Expect = 1e-75
Identities = 266/894 (29%), Positives = 401/894 (44%), Gaps = 81/894 (9%)
Query: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL-YSILVGTPEDYPR 336
+P +YQA +PE N TP + R I P G L Y++ +
Sbjct: 182 QPPSYQATVPE-------NQPAGTP----VASLRAIDPDEGEAGRLEYTMDALFDSRSNQ 230
Query: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPL-PAFAGLHIEILDENNQSPYF 395
FF + P T ++ E ++R+ + A QD+G P A A L I + D N+ P F
Sbjct: 231 FFSLDPVTGAVTTAEELDRETKSTHVFRVTA-QDHGMPRRSALATLTILVTDTNDHDPVF 289
Query: 396 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS---VF 452
Y+ + E+ VG + L + A D D + L S VF
Sbjct: 290 EQQEYKESLRENLEVGYEV---------LTVRATDGDAPPNANILYRLLEGSGGSPSEVF 340
Query: 453 TV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTP 507
+ ++G+ R PVDREE ++Y ++ A D ++ P V + V D NDN P
Sbjct: 341 EIDPRSGVIR---TRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAP 397
Query: 508 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLIT 566
F E Y V V D+ PG V+++TA D D+GSN + Y I+ G A+G F ++ TG +
Sbjct: 398 QFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALD 457
Query: 567 IAPGVEMIVGRTYALTVQAADNA-PPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 625
+ ++ + Y L V+A D PP + + TV + + N + P F + +
Sbjct: 458 VVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDI---NDNAPIFVSTPFQATV 514
Query: 626 SEAMRVGAVLLNLQATDRE-GDS--ITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 682
E++ +G ++L++QA D + GD+ + Y + F ++ TG +++ LDRE D
Sbjct: 515 LESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVD 574
Query: 683 RYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA--NAFVGQV 739
Y + A D G P T++A+V++ V DVNDN P F P + E+A V V
Sbjct: 575 FYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQ--PEYTVRLNEDAAVGTSVVTV 632
Query: 740 KATDPDAGINGQVHYSLGNFNNLFRITS---NGSIYTAVKLNREVRDYYELVVVATDGAV 796
A D DA + GN N F ITS G + A+ L+ ++ Y L V A+DG
Sbjct: 633 SAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT- 691
Query: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRI 856
R T + + V D + + PVF +S YTV V E+ PAGTT++ I A D D G N
Sbjct: 692 --RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY 749
Query: 857 RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIV 916
+ F + TG ++ LDYE + S T + A D + ++V
Sbjct: 750 FMEDSIPQFRIDADTGAVTTQAELDYE----DQVSYTLAITARDNGIPQKSDTTYLEILV 805
Query: 917 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV---DDVQFP 973
D+ND P F + Y+G V D T + + A D D GL RV Y DD
Sbjct: 806 NDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD-SGL-NGRVFYTFQGGDDGD-- 861
Query: 974 YPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP 1033
F VE SG V T L+ E + L A D G P + V + VL + P
Sbjct: 862 ---GDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNP 918
Query: 1034 RFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVI 1089
+++ V E + G V ++A N I+Y IV GN + F ++ +G +
Sbjct: 919 PVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL 978
Query: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
LDYE R YVL +QA S +V + A V++ + D N++PPV
Sbjct: 979 TALVDLDYEDRPEYVLVIQATSAPLV----------SRATVHVRLLDRNDNPPV 1022
Score = 231 bits (588), Expect = 6e-60
Identities = 216/767 (28%), Positives = 342/767 (44%), Gaps = 80/767 (10%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDN+P F + Y V E G + A+D D G N + Y I
Sbjct: 385 VFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVT-----ASDRDKGSNAVVHYSIM 439
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
+ F + TG + + L+YE Y + ++A D + + +T
Sbjct: 440 SG----NARGQFYLDAQ-TGALDVVSPLDYETTKEYTLRVRAQDGGRP--PLSNVSGLVT 492
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
V VLD +D P+F+ + PL Y + +QAID D
Sbjct: 493 VQVLDINDNAPIFVSTPFQATVLESVPLGY-----------------LVLHVQAIDADAG 535
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
D + Y L G D+P F ++ T +S+ ++R+ + ++A +D+G
Sbjct: 536 -----DNARLEYR-LAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSFGVEA-RDHG 586
Query: 373 HP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
P L A A + + +LD N+ +P FT P Y + E A VG TS + + A+D+
Sbjct: 587 TPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG---------TSVVTVSAVDR 637
Query: 432 DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491
D + + + F++T ++L P+D + ++ Y ++TA DG ++
Sbjct: 638 DAHSV--ITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQDT 695
Query: 492 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 551
IV + V DAN + P F Y V V D G +V+ ++A D D G N ITY +
Sbjct: 696 AQIV-VNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-FMED 753
Query: 552 AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN-N 610
+ F I+ TG +T ++ +Y L + A DN P + T Y+E+L + N
Sbjct: 754 SIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSD----TTYLEILVNDVN 809
Query: 611 QSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSET 666
+ P+F + Y + E + +L + ATDR+ + Y + GD F + T
Sbjct: 810 DNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST 869
Query: 667 TGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNL 725
+GI+ + LDRE+ +Y+L A D G P + V + V DVNDN PVF+
Sbjct: 870 SGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFE---QDEF 926
Query: 726 SVVEEEANAF---VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 779
V EE + V +V ATDPD G N Q+ Y + GN +F++ +G + V L+
Sbjct: 927 DVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDY 986
Query: 780 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPA 834
E R Y LV+ AT P S T+ +++LD +DN PV N + Y + P
Sbjct: 987 EDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPG 1043
Query: 835 GTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
G I ++ A D D+ +++Y L+ TGEL L R+LD
Sbjct: 1044 G-AIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
Score = 140 bits (354), Expect = 8e-33
Identities = 159/590 (26%), Positives = 251/590 (42%), Gaps = 76/590 (12%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDN+PTF Y +NE VGT++ T + D A VI
Sbjct: 596 VSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS-----------VIT 644
Query: 193 YNPDDPTSNDTFEIPLMLTGNIV-LRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
Y + + F I G +V L L+Y+ + +Y + + A+D R T +
Sbjct: 645 YQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGT------RQDTAQI 698
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
V+V D + P+F N + RP + I A D+D
Sbjct: 699 VVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----------------ISATDEDT 741
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+ I Y + P+ F + T ++ ++ + + L I A +DN
Sbjct: 742 G-----ENARITYFMEDSIPQ-----FRIDADTGAVTTQAELDYEDQVSYTLAITA-RDN 790
Query: 372 GHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
G P + L I + D N+ +P F SYQG + E P TS L+I A D
Sbjct: 791 GIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPP---------FTSVLQISATD 841
Query: 431 KDIEDTKDPELHLFL--NDYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD-G 486
+D + F +D F V T GI R L L DRE Y A D G
Sbjct: 842 RD-SGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRL---DRENVAQYVLRAYAVDKG 897
Query: 487 VQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
+ + P+ V + V+D NDN P F + +DV+V + G +V ++TA D DEG+N +I
Sbjct: 898 MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIM 957
Query: 546 YEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Y+I+ G + F ++ +G +T ++ Y L +QA +AP R TV++
Sbjct: 958 YQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVLVIQAT-SAPLVSR----ATVHVR 1012
Query: 605 VLPPNNQSPP--RFPQLMYSLEISEAMRV-GAVLLNLQATDRE-GDSITYAIENGDPQRV 660
+L N+ P F L + + + G + + A D + DS+TY+ E G+ +
Sbjct: 1013 LLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSL 1072
Query: 661 FNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTD 709
L+ +TG L L +ALD I+ + SDG T+ + + ++TD
Sbjct: 1073 VLLNASTGELKLSRALDNNRPLEAIMSVLVSDGVHSVTAQCALRVTIITD 1122
Score = 88.6 bits (218), Expect = 5e-17
Identities = 107/446 (23%), Positives = 187/446 (41%), Gaps = 58/446 (13%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
++ + V D N + P F+ Y VNE P GTT+ ATD D G N +I Y +
Sbjct: 697 QIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVL-----ISATDEDTGENARITYFM 751
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
+ S F I TG + + L+YED+ Y + I A D N +++ TT L
Sbjct: 752 E------DSIPQFRIDAD-TGAVTTQAELDYEDQVSYTLAITARD---NGIPQKSDTTYL 801
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
+ V D +D P FL RD +YQ ++ E++ P I A D+D
Sbjct: 802 EILVNDVNDNAPQFL--------RD----SYQGSV-----YEDVPPFTSVLQISATDRDS 844
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+ + Y+ G +D F + + + L ++R+ ++ L A
Sbjct: 845 GL-----NGRVFYTFQGG--DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKG 897
Query: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
P + + +LD N+ P F + ++ E++P+G ++ R+ A D
Sbjct: 898 MPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVA---------RVTATDP 948
Query: 432 DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491
D + + VF + + LT L +D E++ Y I A S
Sbjct: 949 DEGTNAQIMYQIVEGNIPEVFQLDI--FSGELTALVDLDYEDRPEYVLVIQATSAPLVSR 1006
Query: 492 PVIVNIQVMDANDNTPTFP--EISYDVYV--YTDMRPGDSVIQLTAVDADEGSNGEITYE 547
V+++++D NDN P EI ++ YV + PG ++ ++ A D D + +TY
Sbjct: 1007 -ATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYS 1063
Query: 548 ILVGAQGDFI-INKTTGLITIAPGVE 572
G + + +N +TG + ++ ++
Sbjct: 1064 FERGNELSLVLLNASTGELKLSRALD 1089
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 291 bits (746), Expect = 3e-78
Identities = 301/1092 (27%), Positives = 473/1092 (43%), Gaps = 134/1092 (12%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
+ V D ND +PTF+ + Y + E P GT++ T ATD D G NGQ+ Y
Sbjct: 1637 VSVADVNDEAPTFQQQEYSVLLRENNPPGTSLLT-----LRATDPDVGANGQVTY----- 1686
Query: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
S+++F + TG + + L+ E++ + + A DR + + T T+ V
Sbjct: 1687 --GGVSSESFSLDPD-TGVLTTLRALDREEQEEINLTVYAQDRG---SPPQLTHVTVRVA 1740
Query: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
V D +D P F L +PE + P+ L + + P D N Q
Sbjct: 1741 VEDENDHAPTFGSAHL------------SLEVPEGQDPQTLTMLRASDP----DVGANGQ 1784
Query: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
+ Y IL G P F + + E + P++R+ F L I+A +D G P
Sbjct: 1785 -------LQYRILDGDPSGA---FVLDLASGEFGTMRPLDREVEPAFQLRIEA-RDGGQP 1833
Query: 375 -LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
L A L + +LD N+ +P F +P+Y + E P G + L++ A D D
Sbjct: 1834 ALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLL---------LQLQAHDPDA 1884
Query: 434 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE---S 490
+L + +G R L DRE+ +YTFS++A DG S
Sbjct: 1885 GANGHVTYYLGAGTAGAFLLEPSSGELRTAAAL---DREQCPSYTFSVSAVDGAAAGPLS 1941
Query: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDS-------VIQLTAVDADEGSNGE 543
V V I V D ND+ PTFP + + RPG S + L A D D G+N
Sbjct: 1942 TTVSVTITVRDVNDHAPTFPTSPLRLRL---PRPGPSFSTPTLALATLRAEDRDAGANAS 1998
Query: 544 ITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
I Y + ++ TG I +A + R L + A D PA S V I
Sbjct: 1999 ILYRLAGTPPPGTTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPAR---SATGVII 2055
Query: 604 EVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS--ITYAIENGDPQRVF 661
L + PRFP+ I E G +++ +A G + ITY+I +G+ + F
Sbjct: 2056 VGLQGEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSILSGNEKGTF 2115
Query: 662 NLSETTGILTLGKA--LDRESTDRYILIITASDGRPDGTSTATV-NIVVTDVNDNAPVFD 718
++ +TG +T+ A LD E + R L++ A G G TV + + D NDNAP F
Sbjct: 2116 SIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESG---GAFAFTVLTLTLQDANDNAPRF- 2171
Query: 719 PYLPRNLSVVEEEANAFVG---QVKATDPDAGINGQVHYSLGNFN---NLFRIT-SNGSI 771
L + E+ G QV+A D D G GQ+ YSL LF + + G+I
Sbjct: 2172 --LRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTI 2229
Query: 772 YTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEEN 831
T L+RE+ LV++ATD + TL + V+D +DN P + + V E+
Sbjct: 2230 TTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP-WELRVSED 2288
Query: 832 LPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEAS 891
G+ I Q+ DVD G + Y + + F++ + G +SL LD+E +
Sbjct: 2289 ALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQ 2348
Query: 892 ITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAE 951
+ + G A +TV+V+D+ND P FS+ +Y+ M+ G+ I +V A
Sbjct: 2349 LL-------AHDGPHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSAT 2401
Query: 952 DADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN---LNEEPTTIFKLVVVA 1008
D D + Y + PA F V+ ++G + T V L + + +V+ A
Sbjct: 2402 DRDSGA--NGHISYHLAS-----PADGFSVDPNNGTLFTIVGTVALGHDGSGAVDVVLEA 2454
Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA----I 1063
D G P ++ ATV + + + P FT YR +L T++ + + A
Sbjct: 2455 RDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRS 2514
Query: 1064 NQSIVYSIVSGNEEDTFGIN--------------NITGVIYVNGPLDYETRTSYVLRVQA 1109
+ ++ YSI+SGN F + G + + PLD+E+ T Y L V A
Sbjct: 2515 HAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAA 2574
Query: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
A+ P +S+ V + + D N++PPVF + Y V ED + +L V+A+
Sbjct: 2575 -------ADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEAS 2627
Query: 1170 DKDTGNYSVMAY 1181
D D G + ++ +
Sbjct: 2628 DADPGPHGLVRF 2639
Score = 267 bits (683), Expect = 6e-71
Identities = 287/1134 (25%), Positives = 472/1134 (41%), Gaps = 129/1134 (11%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-VI 191
V++ V+D N+++P F + + E G ++T + D GPN + Y ++
Sbjct: 1422 VQVQVQDENEHAPAFARDPLALALPENPEPGAALYTFRASDADGP----GPNSDVRYRLL 1477
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
+ P P TG + + L+ E ++++A DR N + RR +
Sbjct: 1478 RQEPPVPALRLDAR-----TGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSA 1532
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
V V D +D P+F A+ +R PE+ P + A D D
Sbjct: 1533 RVFVTDENDNAPVF------------------ASPSRVRLPEDQPPGPAALHVVARDPDL 1574
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+ + Y + G F +H T LS++ P++R+ + L + A
Sbjct: 1575 -----GEAARVSYRLASGG----DGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHG 1625
Query: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
P A L + + D N+++P F Y + E+ P G TS L + A D
Sbjct: 1626 SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLRENNPPG---------TSLLTLRATDP 1676
Query: 432 DIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQE 489
D+ ++ S+ TG+ LT L+ +DREEQ+ ++ A D +
Sbjct: 1677 DVGANGQVTYGGVSSESFSL--DPDTGV---LTTLRALDREEQEEINLTVYAQDRGSPPQ 1731
Query: 490 SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL 549
V V + V D ND+ PTF + V P ++ L A D D G+NG++ Y IL
Sbjct: 1732 LTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDP-QTLTMLRASDPDVGANGQLQYRIL 1790
Query: 550 VG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
G G F+++ +G ++ V + L ++A D PA + TV VL
Sbjct: 1791 DGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTV--TVLDA 1848
Query: 609 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSE 665
N+ + P FP YS+E+ E + G +LL LQA D + + +TY + G F L
Sbjct: 1849 NDHA-PAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAG-TAGAFLLEP 1906
Query: 666 TTGILTLGKALDRESTDRYILIITASDGRPDG--TSTATVNIVVTDVNDNAPVFDPYLPR 723
++G L ALDRE Y ++A DG G ++T +V I V DVND+AP F P P
Sbjct: 1907 SSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTF-PTSPL 1965
Query: 724 NLSVVE-----EEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--GSIYTA-- 774
L + + ++A D DAG N + Y L + G I A
Sbjct: 1966 RLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPGTTVDSYTGEIRVARS 2025
Query: 775 -VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
V L R L +VATD R +T + + + + P F ++ + EN P
Sbjct: 2026 PVALGPRDR---VLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAP 2082
Query: 834 AGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL--LRSLDYEAFPDQE 889
GT I+ A G N ++Y I S K F++ P TG +++ LD+E P
Sbjct: 2083 PGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSP--R 2139
Query: 890 ASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVY 949
+ E+ + +T+ ++D ND P F + Y + P+ V
Sbjct: 2140 LRLVLQAESGGAF-----AFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVE 2194
Query: 950 AEDADPPGLPASRVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
A+D D ++ Y + Q PA +F V+ +G + T L+ E +LV++A
Sbjct: 2195 ADDLDQGS--GGQISYSLAASQ---PARGLFHVDPTTGTITTTAILDREIWAETRLVLMA 2249
Query: 1009 FDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIV 1068
D G P + SAT+ ++V+ + R T + VSE A G+ + ++ ++ V
Sbjct: 2250 TDRGSPALVGSATLTVMVIDTND-NRPTIPQPWELRVSEDALLGSEIAQVTGNDVDSGPV 2308
Query: 1069 --YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN 1126
Y + +D F + G + + GPLD+E Y L++ A
Sbjct: 2309 LWYVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHD----------GPHEG 2358
Query: 1127 TAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
A + + ++D N++ P F + Y + E +++L V ATD+D+G ++Y L P
Sbjct: 2359 RANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASP 2418
Query: 1187 PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
+GF V+ G + F ++ T G SG DV++
Sbjct: 2419 -----ADGFSVDPNNGTL---------------FTIVGTVALGHDGSGAVDVVL 2452
Score = 255 bits (652), Expect = 2e-67
Identities = 299/1091 (27%), Positives = 460/1091 (42%), Gaps = 123/1091 (11%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
+ V D ND++P F +Y V E P GT + A D D G NG + Y +
Sbjct: 1843 VTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLL-----QLQAHDPDAGANGHVTYYLGAG 1897
Query: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
T+ P +G + L+ E Y + A D A +TT ++T+
Sbjct: 1898 ----TAGAFLLEPS--SGELRTAAALDREQCPSYTFSVSAVDGAAA--GPLSTTVSVTIT 1949
Query: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
V D +D P F PL + P P P + ++A D+D
Sbjct: 1950 VRDVNDHAPTF----------PTSPLRLRLPRPG---PSFSTPTLALATLRAEDRDAGAN 1996
Query: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLVIKAEQDNGH 373
ILY L GTP P + T E+ + PV + ++ D G
Sbjct: 1997 A-----SILYR-LAGTP---PPGTTVDSYTGEIRVARSPVALGPRDRVLFIVAT--DLGR 2045
Query: 374 PLPAFAGLHIEILD-ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
P + G+ I L E + P F S + I E+AP G I SP + A
Sbjct: 2046 PARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPPGTPI------VSPRAVHA---- 2095
Query: 433 IEDTKDPELHLFLN-DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESE 491
T P + L+ + F++ + + + +D E + A G +
Sbjct: 2096 -GGTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAF 2154
Query: 492 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG 551
V+ + + DANDN P F Y ++ ++Q+ A D D+GS G+I+Y +
Sbjct: 2155 TVLT-LTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAAS 2213
Query: 552 --AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
A+G F ++ TTG IT ++ + L + A D PA ++ TV +
Sbjct: 2214 QPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVI---DT 2270
Query: 610 NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTG 668
N + P PQ + L +SE +G+ + + D + G + Y + PQ F++ G
Sbjct: 2271 NDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGG 2329
Query: 669 ILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 728
++L LD E DRY L + A DG +G + TV +V DVNDNAP F L + + +
Sbjct: 2330 RVSLTGPLDFEQCDRYQLQLLAHDGPHEGRANLTV--LVEDVNDNAPAFSQSLYQVMLLE 2387
Query: 729 EEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYT---AVKLNREVRDY 784
+ + V ATD D+G NG + Y L + + F + +NG+++T V L +
Sbjct: 2388 HTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVALGHDGSGA 2447
Query: 785 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 844
++V+ A D R + T+ +++ D +D++P FT S Y V V E+LP G+T+L +EA
Sbjct: 2448 VDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEAT 2507
Query: 845 DVDLG---ANVSYRIRSPEVKHFFALHPFTGE--------------LSLLRSLDYEAFPD 887
D D A V Y I S F L P E L LL LD+E+
Sbjct: 2508 DADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQ 2567
Query: 888 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 947
++ A D + VTV V D+ND PPVF++ Y+ V D G +
Sbjct: 2568 YNLTVA----AADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLH 2623
Query: 948 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1007
V A DADP P VR+ V P+ +FE++E SG + L+ E +LVV
Sbjct: 2624 VEASDADPG--PHGLVRFTVSSGD---PSGLFELDESSGTLRLAHALDCETQARHQLVVQ 2678
Query: 1008 AFDD-GEPVMSSSATVKILVLH------PGEIPRFTQEEYRPPPVSELATKGTMVGVISA 1060
A D G + T+++ ++ P + + E +PP GT+V + A
Sbjct: 2679 AADPAGAHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPP--------GTLVTTLHA 2730
Query: 1061 ----AAINQSIVYSIVSGNE----EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL 1112
A + YS++ + F +N+ TG + P DYE S+ L V A
Sbjct: 2731 IDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
Query: 1113 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1172
NL S S T V + +DE + PVF + V E AR S+ V+ATD+D
Sbjct: 2791 ----GNL---SASVTVSVLVTGEDE--YDPVFLAPAFHFQVPEGARRGHSLGHVQATDED 2841
Query: 1173 TGNYSVMAYRL 1183
G ++ Y L
Sbjct: 2842 GGADGLVLYSL 2852
Score = 254 bits (649), Expect = 5e-67
Identities = 314/1199 (26%), Positives = 497/1199 (41%), Gaps = 141/1199 (11%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
+T R LDR+ I+ V + + VR+ V D ND++PTF V
Sbjct: 1704 TTLRALDREEQEEINLTVYAQD--RGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVP 1761
Query: 158 E-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVL 216
E P T+ A+D D G NGQ++Y I D + F + L +G
Sbjct: 1762 EGQDPQTLTMLR-------ASDPDVGANGQLQYRIL----DGDPSGAFVLDLA-SGEFGT 1809
Query: 217 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMF-LPCVLVPNTR 275
+ L+ E + + + I+A D Q + T LTV VLD +D P F +P V
Sbjct: 1810 MRPLDREVEPAFQLRIEARDGGQ---PALSATLLLTVTVLDANDHAPAFPVPAYSV---- 1862
Query: 276 DCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYP 335
PE++ + +QA D D + Y + GT
Sbjct: 1863 --------------EVPEDVPAGTLLLQLQAHDPDAGANGH-----VTYYLGAGTAGA-- 1901
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQDNGHPLPAFAGLHIEILDENNQSPY 394
F + P + EL ++R+ + + A + PL + I + D N+ +P
Sbjct: 1902 --FLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPT 1959
Query: 395 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD--------PELHLFLN 446
F + + P +T + +L + LR A D+D P ++
Sbjct: 1960 FPTSPLRLRLPRPGPSFSTPTLAL---ATLR--AEDRDAGANASILYRLAGTPPPGTTVD 2014
Query: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNT 506
YT V ++ + L P DR T S ++ + + +
Sbjct: 2015 SYTGEIRVARSPVA-----LGPRDR----VLFIVATDLGRPARSATGVIIVGLQGEAERG 2065
Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLI 565
P FP S + + + PG ++ AV A G+NG ITY IL G + G F I +TG I
Sbjct: 2066 PRFPRASSEATIRENAPPGTPIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAI 2124
Query: 566 TI--APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
T+ A G++ V L +QA A TV L N + PRF + Y
Sbjct: 2125 TVRSAEGLDFEVSPRLRLVLQAESGGAFA------FTVLTLTLQDANDNAPRFLRPHYVA 2178
Query: 624 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQR-VFNLSETTGILTLGKALDRE 679
+ E+ + LL ++A D + G I+Y++ P R +F++ TTG +T LDRE
Sbjct: 2179 FLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAILDRE 2238
Query: 680 STDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVG 737
L++ A+D G P +AT+ ++V D NDN P P L V E+ + +
Sbjct: 2239 IWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQ--PWELRVSEDALLGSEIA 2296
Query: 738 QVKATDPDAG---------INGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELV 788
QV D D+G Q +S+G + +T L+ E D Y+L
Sbjct: 2297 QVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTG--------PLDFEQCDRYQLQ 2348
Query: 789 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
++A DG P L + V D++DN+P F+ S Y V++ E+ P G+ IL + A D D
Sbjct: 2349 LLAHDG---PHEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPPGSAILSVSATDRDS 2405
Query: 849 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
GAN +SY + SP F++ P G L + D ++ ++EA D
Sbjct: 2406 GANGHISYHLASPA--DGFSVDPNNGTLFTIVGT-VALGHDGSGAVDVVLEARDHGAPGR 2462
Query: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
ATV V ++D ND+ P F+ Y+ V D G+ + T+ A DAD A+ V Y
Sbjct: 2463 AARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAA-VDYS 2521
Query: 967 VDDVQ----FPYPASIFEVEEDSGR-------VITRVNLNEEPTTIFKLVVVAFDDGEPV 1015
+ F + E E +G ++ L+ E T + L V A D G+P
Sbjct: 2522 IISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPP 2581
Query: 1016 MSSSATVKILVLHPGEIPR-FTQEEYRPPPVSELATKGTMVGVISAAAI---NQSIVYSI 1071
SS V + VL + P FT+ YR + ++ V ++ A + + +++
Sbjct: 2582 QSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTV 2641
Query: 1072 VSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSN--TAK 1129
SG+ F ++ +G + + LD ET+ + L VQA P+ ++ A
Sbjct: 2642 SSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD----------PAGAHFALAP 2691
Query: 1130 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI-IPPI 1188
V IE+QD N+H P F V+E+ T V + A D D G + + Y L+ P
Sbjct: 2692 VTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLEAGPG 2751
Query: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
EG+E F + + TG ++ + F F+ V A D S VLV+ ++ D
Sbjct: 2752 PEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYD 2810
Score = 250 bits (639), Expect = 7e-66
Identities = 223/768 (29%), Positives = 350/768 (45%), Gaps = 48/768 (6%)
Query: 463 LTLLQPVDREEQQTYTFSITAFDGVQESE--PVIVNIQVMDANDNTPTFPEISYDVYVYT 520
L + +DRE + Y + A+DG ++++ ++D ND+ P F + Y V
Sbjct: 207 LVVTGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSE 266
Query: 521 DMRPGDSVIQLTAVDADEGSNGEITYEI---LVGAQGDFIINKTTGLITIAPGVEMIVGR 577
+ PG V+Q+ A DAD G NG +TYEI G F I+ TGL+ + ++ R
Sbjct: 267 SLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRR 326
Query: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQS-PPRFPQLMYSLEISEAMRVGAVLL 636
+ L VQA D E ++ TV++ N S F S ++SEA G ++
Sbjct: 327 VHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVA 386
Query: 637 NLQATD-REGD--SITYAIENGDPQRVFNLSETTGILTL---GKALDRESTDRYILIITA 690
+ +D +GD + ++E G+ F LS ++ L + LDRE D Y L +TA
Sbjct: 387 RISVSDPDDGDFAHVNVSLEGGEGH--FALSTQDSVIYLVCVARRLDREERDAYNLRVTA 444
Query: 691 SD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDPDAGI 748
+D G P + A + VTDVNDNAP FD L R + E +FV +V A DPD G
Sbjct: 445 TDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGT 504
Query: 749 NGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTL 805
NGQV YSL G + F I ++G I TA L+ E+ +L+VVATDG + P S+ T+
Sbjct: 505 NGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATV 564
Query: 806 AIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRS---PE 860
++ + D++DN P F + Y + E GT LQ+ A D D G +SY + +
Sbjct: 565 SVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSS 624
Query: 861 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMN 920
F + +G++ R+LD + P +S F V A D G + V V + D N
Sbjct: 625 GSPPFRIDAHSGDVCTTRTLDRDQGP---SSFDFTVTAVD--GGGLKSMVYVKVFLSDEN 679
Query: 921 DYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFE 980
D PP F R Y ++ + GT + + A D D R+ Y + P +F
Sbjct: 680 DNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGS--HGRLSYHILAGNSP---PLFT 734
Query: 981 VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1040
++E SG + L ++ +L + A D G SA V I ++ P ++
Sbjct: 735 LDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPIFEQLQ 794
Query: 1041 RPPPVSELATKGTMVGVISA---AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDY 1097
V E GT VG++ A + S+ G+ F ++ ++G++ PLD
Sbjct: 795 YVFSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDR 854
Query: 1098 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDA 1157
E VL ++ V A VP A+V + + D N++ P F + +
Sbjct: 855 EL-LGPVLELE------VRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNT 907
Query: 1158 RMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
T + ++A D D+G S + + L + G F V+ TG ++
Sbjct: 908 APGTPIYTLRALDPDSGVNSRVTFTL----LAGGGGAFTVDPTTGHVR 951
Score = 248 bits (633), Expect = 4e-65
Identities = 312/1242 (25%), Positives = 505/1242 (40%), Gaps = 126/1242 (10%)
Query: 46 IDEESRNGTILVDNM--LIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVL 103
IDEE GT++ D L GTA I V + +D ++ T RVL
Sbjct: 51 IDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVV---RTARVL 107
Query: 104 DRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
DR+ V G + EV + V D ND++P F V E T G
Sbjct: 108 DREQRDRYRFTAVTPD------GATV--EVTVRVADINDHAPAFPQARAALQVPEHTAFG 159
Query: 164 TTIFTGFSGDNGATDIDDGPNGQIEYVIQ-------YNPDDPTSNDTFEIPLMLTGNIVL 216
T A D D G G Y + + + D +P +V+
Sbjct: 160 TRYPL-----EPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVP-----ELVV 209
Query: 217 RKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
L+ E+++ Y + ++A D + R L V +LD +D P F
Sbjct: 210 TGELDRENRSHYMLQLEAYDGG---SPPRRAQALLDVTLLDINDHAPAF----------- 255
Query: 277 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPE-DYP 335
Y A + E P +P++ + A D D + + Y I E D P
Sbjct: 256 -NQSRYHAVVSESLAPG--SPVL---QVFASDADAGVNG-----AVTYEINRRQSEGDGP 304
Query: 336 RFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF 395
F + T L L P++ + + +LV++A HP A + + + D N+ P
Sbjct: 305 --FSIDAHTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQPSM 362
Query: 396 TMPSYQG----YILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSV 451
T+ + E+AP G ++ RI D D D +++ L
Sbjct: 363 TVIFLSADGSPQVSEAAPPGQLVA---------RISVSDPD--DGDFAHVNVSLEGGEGH 411
Query: 452 FTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVNIQVMDANDNTP 507
F + TQ + + + + +DREE+ Y +TA D +E V + V D NDN P
Sbjct: 412 FALSTQDSVIYLVCVARRLDREERDAYNLRVTATDSGSPPLRAEAAFV-LHVTDVNDNAP 470
Query: 508 TFPEISYDVYVYTDMR-PGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLI 565
F Y ++ PG V+++TA D D+G+NG++TY + GA F I+ T+G+I
Sbjct: 471 AFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGII 530
Query: 566 TIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEI 625
T A ++ + L V A D P ++ +V ++ + N + P+F + Y+ +
Sbjct: 531 TTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDV---NDNEPQFQRTFYNASL 587
Query: 626 SEAMRVGAVLLNLQATDREGDS---ITYAI-----ENGDPQRVFNLSETTGILTLGKALD 677
E + G L + ATD + ++Y++ +G P F + +G + + LD
Sbjct: 588 PEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP--FRIDAHSGDVCTTRTLD 645
Query: 678 RES-TDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV 736
R+ + +TA DG S V + ++D NDN P F P + V
Sbjct: 646 RDQGPSSFDFTVTAVDGG-GLKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAV 704
Query: 737 GQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYT-AVKLNREVRDYYELVVVATD 793
+++A DPD G +G++ Y + GN LF + + T A L R +L + A D
Sbjct: 705 LRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAED 764
Query: 794 GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG-ANV 852
G + + I ++ P+F Y V E++ GT++ ++A + A V
Sbjct: 765 GGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPPGRLAPV 824
Query: 853 SYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF-PDQEASITFLVEAFDIYGTMPPG--I 909
+ + + + F+L +G L LR LD E P E + +PP +
Sbjct: 825 TLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLGPVLELEVR-------AGSGVPPAFAV 877
Query: 910 ATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDD 969
A V V++ D+ND P F ++ P+ GTPI T+ A D D S V RV
Sbjct: 878 ARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPD------SGVNSRVTF 931
Query: 970 VQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
F V+ +G V L +L + A D G P +S ++++V
Sbjct: 932 TLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDV 991
Query: 1030 GE---IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS-IVYSIVSGNEEDTFGINNI 1085
G PRF YR S T GT V + A A + I Y + + FG+
Sbjct: 992 GTRGLAPRFNSPTYRVDLPSG-TTAGTQVLQVQAQAPDGGPITYHLAAEGASSPFGLEPQ 1050
Query: 1086 TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ 1145
+G ++V LD E + Y+L+V A V + + ++ TA V + I ++N H P
Sbjct: 1051 SGWLWVRAALDREAQELYILKVMA----VSGSKAELGQQTGTATVRVSILNQNEHSPRLS 1106
Query: 1146 KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
+ V+E+ TSV RV ATD+D+G + Y L + E + F + TG +
Sbjct: 1107 EDPTFLAVAENQPPGTSVGRVFATDRDSGPNGRLTYSL--QQLSEDSKAFRIHPQTGEVT 1164
Query: 1206 TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
T ++S ++ V D S V V+V++ D
Sbjct: 1165 TLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLND 1206
Score = 242 bits (617), Expect = 3e-63
Identities = 295/1132 (26%), Positives = 486/1132 (42%), Gaps = 143/1132 (12%)
Query: 130 YHEVRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
+ +R+VV+D +P F +Y + T GT + A D GP
Sbjct: 981 HFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVL-----QVQAQAPDGGP---- 1031
Query: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
I Y+ ++ F + +G + +R L+ E + Y + + A ++ ++T
Sbjct: 1032 ---ITYHLAAEGASSPFGLEPQ-SGWLWVRAALDREAQELYILKVMAVSGSKAELGQQTG 1087
Query: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
T T+ V +L+ ++ P R T+ L E P + A
Sbjct: 1088 TATVRVSILNQNEHSP-----------RLSEDPTF------LAVAENQPPGTSVGRVFAT 1130
Query: 308 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 367
D+D P+ R + YS L ED + F +HP+T E++ L+ ++R+ + L+++
Sbjct: 1131 DRDSG---PNGR--LTYS-LQQLSED-SKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQV 1183
Query: 368 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
+ P +H+ +LD N+ SP F S +A G I + +
Sbjct: 1184 QDGGSPPRSTTGTVHVAVLDLNDNSPTFLQAS------GAAGGGLPIQVPDRVPPGTLVT 1237
Query: 428 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRY--------LTLLQPVDREEQQTYTF 479
L KDP+ + T ++T+T G + L P+ R E+ Y
Sbjct: 1238 TLQ-----AKDPDEG---ENGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVL 1289
Query: 480 SITAFDGVQESEPVIVNIQVM--------------DANDNTPTFP-EISYDVYVYTDMRP 524
+++A D Q S P ++Q++ D + P P + V +RP
Sbjct: 1290 TLSAHD--QGSPPRSASLQLLVQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRP 1347
Query: 525 GDSVIQLTAVDADEGSNGEITYEILVGA--QGDFIINKTTGLITIAPGVEMIVGRTY-AL 581
G + + A + G +TY ++ GA +G F ++ +G + +A ++ G + AL
Sbjct: 1348 GSLLGSVAA--PEPAGVGALTYTLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRAL 1405
Query: 582 TVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQAT 641
TV+A R + V ++V N+ P F + +L + E GA L +A+
Sbjct: 1406 TVRAEGPGGAGAR---LLRVQVQV-QDENEHAPAFARDPLALALPENPEPGAALYTFRAS 1461
Query: 642 DREG----DSITYAIENGDPQ-RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 696
D +G + Y + +P L TG L+ + LDRE+T +L++ A+D RP
Sbjct: 1462 DADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRETTPALLLLVEATD-RPA 1520
Query: 697 GTST-----ATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVG-QVKATDPDAGING 750
S + + VTD NDNAPVF P + + E++ V A DPD G
Sbjct: 1521 NASRRRAARVSARVFVTDENDNAPVFAS--PSRVRLPEDQPPGPAALHVVARDPDLGEAA 1578
Query: 751 QVHYSLGNFNN-LFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
+V Y L + + FR+ +S G++ L+RE R + L VVA+D PR +T L +
Sbjct: 1579 RVSYRLASGGDGHFRLHSSTGALSVVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVS 1638
Query: 809 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 866
V D++D +P F Y+VL+ EN P GT++L + A D D+GAN V+Y S E F+
Sbjct: 1639 VADVNDEAPTFQQQEYSVLLRENNPPGTSLLTLRATDPDVGANGQVTYGGVSSE---SFS 1695
Query: 867 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGI--ATVTVIVKDMNDYPP 924
L P TG L+ LR+LD E ++ I V A D PP + TV V V+D ND+ P
Sbjct: 1696 LDPDTGVLTTLRALDRE----EQEEINLTVYAQD--RGSPPQLTHVTVRVAVEDENDHAP 1749
Query: 925 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEED 984
F + + P+ +T + A D D +++YR+ D P+ F ++
Sbjct: 1750 TFGS-AHLSLEVPEGQDPQTLTMLRASDPDVGA--NGQLQYRILDGD---PSGAFVLDLA 1803
Query: 985 SGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPP 1043
SG T L+ E F+L + A D G+P +S++ + + VL + P F Y
Sbjct: 1804 SGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAY-SV 1862
Query: 1044 PVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYET 1099
V E GT++ + A A N + Y + +G F + +G + LD E
Sbjct: 1863 EVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGT-AGAFLLEPSSGELRTAAALDREQ 1921
Query: 1100 RTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARM 1159
SY V A + S T V I ++D N+H P F +
Sbjct: 1922 CPSYTFSVSA------VDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPS 1975
Query: 1160 FT----SVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA 1207
F+ ++ ++A D+D G + + YRL P G V++YTG I+ A
Sbjct: 1976 FSTPTLALATLRAEDRDAGANASILYRLAGTP----PPGTTVDSYTGEIRVA 2023
Score = 237 bits (604), Expect = 8e-62
Identities = 257/1049 (24%), Positives = 439/1049 (41%), Gaps = 132/1049 (12%)
Query: 111 IHSIVVQVQC--INKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFT 168
+H +VVQ + + ++G+ V + VRD NDN P+ T IF
Sbjct: 327 VHELVVQARDGGAHPELGSAF---VTVHVRDANDNQPSM----------------TVIF- 366
Query: 169 GFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN--------------- 213
S D + P GQ+ V + + DP D + + L G
Sbjct: 367 -LSADGSPQVSEAAPPGQL--VARISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYL 423
Query: 214 IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273
+ + +RL+ E++ Y + + A D + + V D +D P F
Sbjct: 424 VCVARRLDREERDAYNLRVTATDSG---SPPLRAEAAFVLHVTDVNDNAPAF-------- 472
Query: 274 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPED 333
R L +PE+ P +V + DQ N Q + YS+ G
Sbjct: 473 ---DRQLYRPEPLPEVALP---GSFVVRVTARDPDQGTNGQ-------VTYSLAPGA--- 516
Query: 334 YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSP 393
+ +F + P + ++ ++ + + L++ A PL + A + + + D N+ P
Sbjct: 517 HTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEP 576
Query: 394 YFTMPSYQGYILESAPVGA-----TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDY 448
F Y + E G T +D+ + L +L + + P + + +
Sbjct: 577 QFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPPFRI--DAH 634
Query: 449 TSVFTVTQTGITRYLTLLQPVDREE-QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTP 507
+ T+T +DR++ ++ F++TA DG V V + + D NDN P
Sbjct: 635 SGDVCTTRT-----------LDRDQGPSSFDFTVTAVDGGGLKSMVYVKVFLSDENDNPP 683
Query: 508 TFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLIT 566
F Y + PG +V++L A D D+GS+G ++Y IL G F +++ +GL+T
Sbjct: 684 QFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLT 743
Query: 567 IAPGVEMIVGRTYALTVQAAD----NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYS 622
+A + L + A D A P+ R V I ++ P +PP F QL Y
Sbjct: 744 VAWPLARRANSVVQLEIGAEDGGGLQAEPSAR------VDISIV-PGTPTPPIFEQLQYV 796
Query: 623 LEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
+ E + G + +QA + G +T ++ GDP+ +F+L +G+L + LDRE
Sbjct: 797 FSVPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDREL 856
Query: 681 TDRYI-LIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQV 739
+ L + A G P + A V +++ DVNDN+P F L + +
Sbjct: 857 LGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTL 916
Query: 740 KATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVH 797
+A DPD+G+N +V ++L G + G + L +EL + A DG
Sbjct: 917 RALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSP 976
Query: 798 PRHSTLTLAIKVLDIDDN--SPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYR 855
PR S L + V D+ +P F + TY V + AGT +LQ++A+ D G ++Y
Sbjct: 977 PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPD-GGPITYH 1035
Query: 856 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGT-----MPPGIA 910
+ + F L P +G L + +L D+EA ++++ + G+ G A
Sbjct: 1036 LAAEGASSPFGLEPQSGWLWVRAAL------DREAQELYILKVMAVSGSKAELGQQTGTA 1089
Query: 911 TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDV 970
TV V + + N++ P S+ VA + GT + V+A D D P R+ Y +
Sbjct: 1090 TVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDSG--PNGRLTYSLQ-- 1145
Query: 971 QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG 1030
Q + F + +G V T L+ E + ++L+V D G P S++ TV + VL
Sbjct: 1146 QLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVLDLN 1205
Query: 1031 E-IPRFTQEEYR-----PPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTF 1080
+ P F Q P V + GT+V + A N +I+Y++ +G + F
Sbjct: 1206 DNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTL-TGPGSELF 1264
Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQA 1109
++ +G + PL R YVL + A
Sbjct: 1265 SLHPHSGELLTAAPLIRAERPHYVLTLSA 1293
Score = 227 bits (578), Expect = 8e-59
Identities = 291/1105 (26%), Positives = 464/1105 (41%), Gaps = 145/1105 (13%)
Query: 40 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
PA V + E+ GT+L+ AG +V Y++ L S+
Sbjct: 1858 PAYSVEVPEDVPAGTLLLQLQAHDPDAGA---------NGHVTYYLGAGTAGAFLLEPSS 1908
Query: 100 GRV-----LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYY 153
G + LDR+ P S+ + T + V I VRD ND++PTF
Sbjct: 1909 GELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTTV--SVTITVRDVNDHAPTFPTSPLR 1966
Query: 154 ATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGN 213
+ P +T + A D D G N I Y + P T+ D++ TG
Sbjct: 1967 LRLPRPGPSFSTPTLALATLR-AEDRDAGANASILYRLAGTPPPGTTVDSY------TGE 2019
Query: 214 I-VLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD-DLGPMFLPCVLV 271
I V R + + R I+ A +L + T + + L G+ + GP F
Sbjct: 2020 IRVARSPVALGPRDRVLFIV-----ATDLGRPARSATGVIIVGLQGEAERGPRF------ 2068
Query: 272 PNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTP 331
P +A I E PP I R + I YSIL G
Sbjct: 2069 PRASS------EATIREN-----------APPGTPIVSPRAVHAGGTNGPITYSILSGNE 2111
Query: 332 EDYPRFFHMHPRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDEN 389
+ F + P T +++ DF + LV++AE AF L + + D N
Sbjct: 2112 KGT---FSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAF---AFTVLTLTLQDAN 2165
Query: 390 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFL---N 446
+ +P F P Y ++ ES P L PL V D D++ ++ L
Sbjct: 2166 DNAPRFLRPHYVAFLPESRP----------LEGPLLQVEAD-DLDQGSGGQISYSLAASQ 2214
Query: 447 DYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVN-----IQVMD 501
+F V T T +T +DRE + A D P +V + V+D
Sbjct: 2215 PARGLFHVDPT--TGTITTTAILDREIWAETRLVLMATD---RGSPALVGSATLTVMVID 2269
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV--GAQGDFIIN 559
NDN PT P+ +++ V D G + Q+T D D +G + + +L G Q F +
Sbjct: 2270 TNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSPSGPQDPFSVG 2325
Query: 560 KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQL 619
+ G +++ ++ Y L + A D P E R ++ TV +E + N + P F Q
Sbjct: 2326 RYGGRVSLTGPLDFEQCDRYQLQLLAHDG--PHEGRANL-TVLVEDV---NDNAPAFSQS 2379
Query: 620 MYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGIL--TLGK 674
+Y + + E G+ +L++ ATDR+ + I+Y + + P F++ G L +G
Sbjct: 2380 LYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLAS--PADGFSVDPNNGTLFTIVGT 2437
Query: 675 -ALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
AL + + +++ A D G P + ATV++ + D ND+AP F R +
Sbjct: 2438 VALGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPP 2497
Query: 733 NAFVGQVKATDPDAG-INGQVHYSL--GNFNNLFRITSN---------------GSIYTA 774
+ + ++ATD D + V YS+ GN+ +F++ G +
Sbjct: 2498 GSTLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLL 2557
Query: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
L+ E Y L V A D P+ S + + + VLD++DN PVFT ++Y V V E+ P
Sbjct: 2558 EPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPV 2617
Query: 835 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
G +L +EA D D G + V + + S + F L +G L L +LD E +A
Sbjct: 2618 GAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCET----QARH 2673
Query: 893 TFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
+V+A D G +A VT+ V+D+ND+ P F + VA + GT +TT++A D
Sbjct: 2674 QLVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTTLHAID 2732
Query: 953 ADPPGLPASRVRYRVDDV-QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD 1011
D R+RY + + P F + +G + RV + E T F+L+V A D
Sbjct: 2733 GDAGAF--GRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADA 2790
Query: 1012 GEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----AINQS 1066
G +S+S TV +LV E P F + V E A +G +G + A +
Sbjct: 2791 GN--LSASVTVSVLVTGEDEYDPVFLAPAFHFQ-VPEGARRGHSLGHVQATDEDGGADGL 2847
Query: 1067 IVYSIVSGNEEDTFGINNITGVIYV 1091
++YS+ + + FGIN TG +Y+
Sbjct: 2848 VLYSLATSSPY--FGINQTTGALYL 2870
Score = 84.0 bits (206), Expect = 1e-15
Identities = 112/464 (24%), Positives = 189/464 (40%), Gaps = 79/464 (17%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDG-PNGQIEY-- 189
V + ++D+ND++P+F Y V E P G+T+ T ATD D + ++Y
Sbjct: 2468 VHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLT-----LEATDADGSRSHAAVDYSI 2522
Query: 190 -------VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 242
V Q P + ++ G +VL + L++E T+Y + + A DR Q
Sbjct: 2523 ISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQ--- 2579
Query: 243 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 302
+++ +TV VLD +D P+F TR +Y+ +PE TP + V
Sbjct: 2580 PPQSSVVPVTVTVLDVNDNPPVF--------TR----ASYRVTVPE-DTPVGAELLHV-- 2624
Query: 303 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362
+A D D P + +++ G P F + + L L ++ + +
Sbjct: 2625 --EASDAD-----PGPHGLVRFTVSSGDPSG---LFELDESSGTLRLAHALDCETQARHQ 2674
Query: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
LV++A G A A + IE+ D N+ P F + + E+ P G ++
Sbjct: 2675 LVVQAADPAGAHF-ALAPVTIEVQDVNDHGPAFPLNLLSTSVAENQPPGTLVTT------ 2727
Query: 423 PLRIVALDKD-----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDR 471
+ A+D D +E PE F + + T L P D
Sbjct: 2728 ---LHAIDGDAGAFGRLRYSLLEAGPGPEGR-------EAFALNSS--TGELRARVPFDY 2775
Query: 472 EEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 531
E +++ + A D S V V++ V ++ P F ++ V R G S+ +
Sbjct: 2776 EHTESFRLLVGAADAGNLSASVTVSVLVTGEDEYDPVFLAPAFHFQVPEGARRGHSLGHV 2835
Query: 532 TAVDADEGSNGEITYEILVGAQGDFIINKTTGLITI-----APG 570
A D D G++G + Y L + F IN+TTG + + APG
Sbjct: 2836 QATDEDGGADGLVLYS-LATSSPYFGINQTTGALYLRVDSRAPG 2878
Score = 52.0 bits (123), Expect = 5e-06
Identities = 68/290 (23%), Positives = 106/290 (36%), Gaps = 45/290 (15%)
Query: 981 VEEDSGRVITRVNLNEEPTTIFKLVVVAFD--------------DGEPVMSSSATVKILV 1026
++E SG V T L+ E ++ V D D P + +
Sbjct: 94 IDEHSGVVRTARVLDREQRDRYRFTAVTPDGATVEVTVRVADINDHAPAFPQARAALQVP 153
Query: 1027 LHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1086
H R+ E R L T+G Y++ +TF +
Sbjct: 154 EHTAFGTRYPLEPARDADAGRLGTQG----------------YALSGDGAGETFRLETRP 197
Query: 1087 GV-------IYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1139
G + V G LD E R+ Y+L+++A + P + A + + + D N+
Sbjct: 198 GPDGTPVPELVVTGELDRENRSHYMLQLEA-------YDGGSPPRRAQALLDVTLLDIND 250
Query: 1140 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
H P F + Y VSE + VL+V A+D D G + Y I EG F ++
Sbjct: 251 HAPAFNQSRYHAVVSESLAPGSPVLQVFASDADAGVNGAVTYE-INRRQSEGDGPFSIDA 309
Query: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQ 1249
+TGL++ +R + V A D G A V V V + D Q
Sbjct: 310 HTGLLQLERPLDFEQRRVHELVVQARDGGAHPELGSAFVTVHVRDANDNQ 359
Score = 31.6 bits (70), Expect = 6.8
Identities = 26/91 (28%), Positives = 40/91 (43%), Gaps = 18/91 (19%)
Query: 1375 GALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQAALPAAKPAVPAPAPVAA 1434
GA+ A ++++ + A+++ LV R R+AE QAA P A ++
Sbjct: 2939 GAVAASLGVVVVLALAALVLGLVRARS---RKAEAAPGPMSQAA-PLASDSLQKLGR--- 2991
Query: 1435 PPPPPPPPPGAHLYEELGDSSMHKYEMPQYG 1465
PP PPP HLY + +P YG
Sbjct: 2992 --EPPSPPPSEHLYHQ---------TLPSYG 3011
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 290 bits (743), Expect = 6e-78
Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)
Query: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
Query: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Query: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
Query: 308 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
Query: 367 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
Query: 423 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
Query: 478 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
Query: 537 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
Query: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
+ V I VL N+ + P F + Y + E L+ L+ATD + + ITY+I
Sbjct: 543 TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
Query: 654 NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707
+ + +L E G++++ + LD E Y+ ++ G P ST V I V
Sbjct: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
Query: 708 TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761
D NDN P F Y +SVVE A A V + ATD D GQ + YSL +
Sbjct: 662 FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
Query: 762 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818
FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+DN P
Sbjct: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
Query: 819 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876
+ ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ TG++
Sbjct: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
Query: 877 LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931
+ LD E EA + + PP ATV V + D+ND P F +
Sbjct: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
Query: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
V G I V A D D GL V YR + P F + SG V+T
Sbjct: 896 VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
Query: 992 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050
L+ E ++L VVA D G P SS++T+ I VL E P F Y ++
Sbjct: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
Query: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
+ +V + + +N + Y I GN + F + V+ LD ET +Y+L +
Sbjct: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
Query: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
+A + N V + + TA V++ + D N++ P+F + Y V ED S+L++
Sbjct: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
Query: 1167 KATDKDTGNYSVMAYRLI 1184
KATD D G + + YR++
Sbjct: 1125 KATDADEGEFGRVWYRIL 1142
Score = 284 bits (727), Expect = 4e-76
Identities = 345/1337 (25%), Positives = 584/1337 (43%), Gaps = 155/1337 (11%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKF-----DLVIKA 367
I ++ L+G F ++ T +++ V D + F +L++ A
Sbjct: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIID-REAFSPPILELLLLA 2043
Query: 368 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
E D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++
Sbjct: 2044 E-DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVT 2092
Query: 428 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG- 486
A D+D + + TG+ R +DREEQ++Y ++ A D
Sbjct: 2093 ATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRG 2150
Query: 487 -VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
V S IV I + D ND+ P F V V PG + +TA+D D N ++
Sbjct: 2151 TVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLE 2208
Query: 546 YEI-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA- 592
Y I LV Q D F +N TG + + + + TY +T+ DNA
Sbjct: 2209 YHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLP 2268
Query: 593 ERRNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---G 645
ER S+ + + VL N+ +P P + Y +E I E G L+ + A D +
Sbjct: 2269 ERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLN 2328
Query: 646 DSITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 703
+TY + + P L +++ G + + +D E + ASD G P + V
Sbjct: 2329 GLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPV 2388
Query: 704 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLF 763
+ + D+NDN P+FD + + + V ATD D+G + YSLG+ + F
Sbjct: 2389 YLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKF 2448
Query: 764 RIT-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPV 818
I + G IY L+RE +D+Y L +A D A + R +++ + I+VLD++D P
Sbjct: 2449 AINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQ 2508
Query: 819 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876
F+ ++ V EN PAGT+++ + A D D G N ++Y + P V+ F + +G ++
Sbjct: 2509 FSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTT 2567
Query: 877 LRSLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKG 933
R L YE F + V A D G PP G + V V D+ND PVF +
Sbjct: 2568 QRPLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGT 2618
Query: 934 M--VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
+ + + + + VYA D D GL + VRY F ++ SG + T
Sbjct: 2619 ILHIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTA 2676
Query: 992 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPP 1044
L+ E ++ L++VA D G+PV + + L P F + +Y+
Sbjct: 2677 QRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLT 2736
Query: 1045 VSELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYET 1099
V E + +GT+VG ++ A N + Y I +GNEE F + G + V LD E
Sbjct: 2737 VPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDRER 2795
Query: 1100 RTSYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGV 1153
+ V+A S L + + +V + ++D N+ PP F K Y GV
Sbjct: 2796 EAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGV 2855
Query: 1154 SEDARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIK 1205
+ DA++ + +++V A D D GN YS++A +R + ++ + F + + G+++
Sbjct: 2856 ATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILR 2915
Query: 1206 TAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEK 1262
T LF YF ++A D L+G D + + L D +V IV N P V
Sbjct: 2916 TFDLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRG 2970
Query: 1263 KIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAID 1322
E+ +L I GA +V + + H D ++ + +L ++ ++ TNR +D
Sbjct: 2971 FEEEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILD 3023
Query: 1323 RNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAF 1382
+ + + +D + F+ Y +L+++ +V + + + + A++ LA
Sbjct: 3024 VDRVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAI 3074
Query: 1383 IIILCCIPAILVVLVSY 1399
++ L A+L VL+++
Sbjct: 3075 LLFLA---AMLFVLMNW 3088
Score = 280 bits (716), Expect = 8e-75
Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)
Query: 39 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
Query: 95 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
Query: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Query: 208 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
Query: 264 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323
+F +PL Y ++ E N + T + + D + + +
Sbjct: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
Query: 324 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Query: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
+LD N+ P F +Y G + E+ P ++T +R+ A D+D +
Sbjct: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
Query: 444 F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498
+ + S F ++ +++ +P+D E+ +T + P V V I+
Sbjct: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
Query: 499 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555
V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y + Q
Sbjct: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
Query: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615
F IN +G IT ++ Y L V+A D ++ I TV I +L N+ P
Sbjct: 719 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
Query: 616 FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671
+ Y + + E + + + A D E ++ Y+I+ P + ++L+ TTG I T
Sbjct: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
Query: 672 LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722
LDRE+ D R I++ GRP TS+ATV + + D+NDN P F LP
Sbjct: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
Query: 723 RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778
V+E A + QV A D D G+NG V Y + G F I +S+G + T +L+
Sbjct: 895 FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
Query: 779 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838
RE Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++P +
Sbjct: 955 RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
Query: 839 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
+ + D D+G N +SY I V F++ + + LD E A+ ++
Sbjct: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
Query: 897 EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
EA D G G ATV V V D+ND P+F + Y+ V D +G I + A DAD
Sbjct: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
Query: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013
RV YR + + F + +G ++ L+ E + L+V A++
Sbjct: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
Query: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068
M SS V + V E P FTQ++Y + E A GT V V+ A + +
Sbjct: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
Query: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Y I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
Query: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
Query: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
+ K F ++ TG+I L + ++ V+A DD G + V ++V+++ D
Sbjct: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
Score = 275 bits (703), Expect = 3e-73
Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
Query: 191 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
Query: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
L V +LD +D P+ P Y ++ E + ++
Sbjct: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
Query: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
Query: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
Query: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
Query: 483 AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
Query: 536 ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592
D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A D P
Sbjct: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
Query: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649
+S V I VL N+ P L ++ ISE V + + ++ A+D + +T
Sbjct: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
Query: 650 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704
+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A +
Sbjct: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
Query: 705 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759
I ++D NDN P+F + + A + G + A D D I V Y L G
Sbjct: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
Query: 760 NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
+ LF I S+ + T V ++RE EL+++A D + +ST L I +LD +D
Sbjct: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
Query: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872
N P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F +H TG
Sbjct: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
Query: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931
++R + +++ S V A D GT+P G A VT+++ D+ND P F I
Sbjct: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
Query: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983
V A GT I + A D D ++ Y + DD P F V
Sbjct: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
Query: 984 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036
++G V+ + +N E +++ + D+ V ++ TV +L ++ P+F
Sbjct: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
Query: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089
Y + E AT GT + ++A +N + Y+++ + + + G +
Sbjct: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
Query: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149
N +DYE V + V ++ P ++ VY+EI D N++ P+F + Y
Sbjct: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
Query: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209
V ED + T +L V ATD D+GN++++ Y L +G+ F + TG I
Sbjct: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
Query: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
++ ++ +A D+ G S + + V VV Q+
Sbjct: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
Score = 274 bits (700), Expect = 6e-73
Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)
Query: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
Query: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
Query: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
Query: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
+Y+AAI E L IV +ID I Y T
Sbjct: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
Query: 398 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
S I E PVG ++ + A D D L + F +
Sbjct: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
Query: 457 TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
Query: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Query: 572 EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629
++ Y L D P ++ VY+ ++ N+ +P F Q Y + + E
Sbjct: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
Query: 630 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685
+ L+ +QA D + ++TYAI G+ F + G++T K LD E S RY
Sbjct: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
Query: 686 LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741
LI+TA+D P TST TV + V D+NDN P F V E + V A
Sbjct: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
Query: 742 TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796
D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D +
Sbjct: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
Query: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854
P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++
Sbjct: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
Query: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910
I + + F ++ TG +++ R LD E P+ + +I+ + P IA
Sbjct: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
Query: 911 -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965
+ + + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y
Sbjct: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
Query: 966 RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021
++ Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A
Sbjct: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
Query: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073
+ I +L + P F+ E PP S L T + +N +VY I +
Sbjct: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
Query: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
G +D F I+ +TGVI V N +D E + SY L V A V S TA V I
Sbjct: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
Query: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191
I D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
Query: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240
++ F V TG + M +S +++AT + + A L V
Sbjct: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
Query: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285
SV N + V V +V + K +T ++R ++ PG ++
Sbjct: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
Score = 223 bits (568), Expect = 1e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 390 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
Query: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
Query: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
Query: 566 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
Query: 624 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
Query: 681 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
Query: 733 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
Query: 781 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
Query: 840 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
Query: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
Query: 958 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
Query: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
Query: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
Query: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
Query: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
Query: 1240 VSVVNQLDMQVIVSNVP 1256
V++++ D N+P
Sbjct: 878 VNLLDLNDNDPTFQNLP 894
Score = 89.0 bits (219), Expect = 4e-17
Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)
Query: 40 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
P+ A+ E+ GTI++ + G IE SL D + + + L+S
Sbjct: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
Query: 100 GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150
R L +D P ++ S N++ ++ +V I V D ND P F
Sbjct: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
Query: 151 SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210
+ +V E P GT++ T ATD D+GPNG++ Y ++ + F + M
Sbjct: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
+G + ++ L +K + + + A D + TT L V+V+D +D P+F V
Sbjct: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
PN I +R L + + A D+D + + YS L
Sbjct: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388
FF + P + + + ++R+ + L++ A D G P+P L + + D
Sbjct: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
Query: 389 NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442
++ P F P S Q +L E +P G + N+T A+D D
Sbjct: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
Query: 443 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487
+ + F + G L +L+ +DRE + ++F + A D V
Sbjct: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
Query: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
+ V + + D ND P F + Y V TD + G +IQ+ A+DAD G+N + Y
Sbjct: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
Query: 548 IL 549
IL
Sbjct: 2885 IL 2886
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 281 bits (720), Expect = 3e-75
Identities = 342/1283 (26%), Positives = 554/1283 (43%), Gaps = 165/1283 (12%)
Query: 133 VRIVVRDRNDNSPTFKH----ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIE 188
V + V D NDN P F + + V E PV + T F A D D+G N ++
Sbjct: 825 VYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVF-----AKDPDEGNNAEVT 879
Query: 189 YVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTT 248
Y + S+D F+I G I L+Y+ + Y + + A D+ + +
Sbjct: 880 YSVS----SEDSSDHFKIDAN-NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Query: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAID 308
+ + G ++ N R L PE L P + I++ D
Sbjct: 935 NIQVIPLSKGR--------AIMSQNIR------------HLIIPENLKPTKIMSLIKSSD 974
Query: 309 QDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL-VIKA 367
++Q + G L+ +V +D F + T +L L + ++ + + VI
Sbjct: 975 ---HLQQHYN--GKLHFSIVADDKD--GHFEIDSSTGDLFLSKELDYETTSHYLFRVITT 1027
Query: 368 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI-------SDSLNL 420
+ L + L I++ D+N+ SP F + E+ P+G + D L
Sbjct: 1028 DHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL 1087
Query: 421 TSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFS 480
S ++ E H N T+ F + + T L + +DRE T +
Sbjct: 1088 NSRIQYYI-----------ESH---NPGTNPFLIHPSFGT--LVTVSRLDRESIPTVILT 1131
Query: 481 ITAFDGV-----QESEPVIVNIQVMDANDNTPTFPEISY-DVYVYTDMRPGDSVIQLTAV 534
+TA D + + I ++D ND+ PTF IS+ + +V D+ G V +TA
Sbjct: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAH 1189
Query: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
D DEG NG++TY IL G + F++++++GL+T ++ + + LTV A D+ PA
Sbjct: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPA- 1248
Query: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITY 650
+S T+ + VL N+++P F Q +Y + E G + ++A DR+ + +
Sbjct: 1249 -LSSSQTLTVTVLDVNDEAPV-FKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF 1306
Query: 651 AIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVVTD 709
I G +F ++ TG + LDRE + + L + DG P +ST T+ V D
Sbjct: 1307 EIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVED 1366
Query: 710 VNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS 767
ND+AP F ++ V+E + V V A+D DAG N V Y + GN + F I
Sbjct: 1367 ENDHAPEF-IVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINE 1425
Query: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
+G + T L+RE + LV++ +D PR S + L ++VLD +D+SP F Y
Sbjct: 1426 MSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
Query: 827 LVEENLPAGTTILQIEAKDVDLGAN-VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAF 885
V E+ GT +L + A D D G N + + E F + P +G L +LD EA
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREA- 1544
Query: 886 PDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
+ TF A D I G+ + + V V D+ND PV + + ++P++
Sbjct: 1545 ---RSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQ 1600
Query: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFK 1003
V A+D D P V + + Q S+F +++ +G + + N + E I+
Sbjct: 1601 TTVIVRADDLDLG--PNGTVVFSFAETQ-----SMFSIDKYTGEIQFQQNPSSEYFPIW- 1652
Query: 1004 LVVVAFDDGEPVMSSSATVKILVLH-PGEIPR--FTQEEYRPPPVSELATKGTMVGVISA 1060
L + D G P + T +LV+H GE + F+ Y+ V+E GT + + A
Sbjct: 1653 LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYK-GLVTENCEAGTSIVTVKA 1708
Query: 1061 AA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGP--LDYETRTSYVLRVQADSLEVV 1115
A I S+ YSI SGNE+ + + +G + V P LD+E R L V A+S
Sbjct: 1709 FAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAES---- 1764
Query: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
KV + IQDEN++ P F++ Y VSE V++V ATD D+G
Sbjct: 1765 ------SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGL 1818
Query: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
++ Y ++ +E F ++ +G+I T + S + V ATD KG+
Sbjct: 1819 NGLIEYSIL---SGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATD---KGMPRL 1872
Query: 1236 ADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHG 1295
++ V V D I N P L + +E ++ +PG V S+
Sbjct: 1873 SNTTVIKVQVTD---INDNAPAFLPSEAVE--------ITEDSLPGVIVTHVSVHDVDLN 1921
Query: 1296 DAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIR 1355
AF + + K +P T AID+N L L DF+ E+
Sbjct: 1922 SAF-IFSFAK------ESNPGTKFAIDQNTGVVVLVKTL-----DFE----------EMT 1959
Query: 1356 TPEAVTSIKKRGESLGYTEGALL 1378
E + I +S+ YTEGAL+
Sbjct: 1960 EYELLIQI---SDSVHYTEGALV 1979
Score = 275 bits (702), Expect = 4e-73
Identities = 305/1148 (26%), Positives = 493/1148 (42%), Gaps = 130/1148 (11%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
+ V D ND +P FK Y A+V E G F A D D G N ++++ I
Sbjct: 1257 VTVLDVNDEAPVFKQHLYEASVKENQNPGE-----FVTRVEALDRDSGVNSKLQFEIMPG 1311
Query: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
S + FEI TG +V L+ E + + + + D ++TTT+
Sbjct: 1312 ----ASFELFEINSD-TGEVVTTTILDREIQEVFTLRVLVRDGGF---PSLSSTTTILCT 1363
Query: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
V D +D P F+ +Y + E + PE + ++ A D D
Sbjct: 1364 VEDENDHAPEFIVS------------SYDIEVLENQEPEVVYTVL------ASDMDAG-- 1403
Query: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP 374
+ + Y I+ G ++ F ++ + ELS ++R+ F LVI P
Sbjct: 1404 ---NNRAVEYHIIDGNTDEC---FTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP 1457
Query: 375 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 434
+ L + +LD N+ SP F YQ + E A VG + L + A+DKD
Sbjct: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVV---------LVLSAVDKD-- 1506
Query: 435 DTKDPELHLFLNDYTS-VFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQ--ES 490
+ + + FL D S FT+ T L +DRE + +TFS A D +Q S
Sbjct: 1507 EGLNGQTEYFLTDEASGAFTIDPMSGT--LKTSNTLDREARSQHTFSAVARDCSIQGSRS 1564
Query: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
VI+ + V D NDN P + +DV++ + + + + A D D G NG + +
Sbjct: 1565 TTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-A 1623
Query: 551 GAQGDFIINKTTGLITIA--PGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
Q F I+K TG I P E L ++ D PA + +++E
Sbjct: 1624 ETQSMFSIDKYTGEIQFQQNPSSEYF---PIWLQLKVTDQGIPARTTTGLLVIHME---- 1676
Query: 609 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQA--TDREGDSITYAIENGDPQRVFNLSET 666
F +Y ++E G ++ ++A D DS+ Y+I +G+ V +L
Sbjct: 1677 GEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSK 1736
Query: 667 TGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 724
+G LT+ K LD E + LI+ A + V +++ D NDN+P F+ + +
Sbjct: 1737 SGQLTVKEPKFLDFEVRNEVQLIVLAESS--GHRAYCKVAVLIQDENDNSPCFEQSIYQA 1794
Query: 725 LSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
+ NA V QV ATD D+G+NG + YS+ GN F+I + +G I T L+ E+
Sbjct: 1795 SVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDYEL 1854
Query: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
Y L+V ATD + +T + ++V DI+DN+P F S + E++LP G + +
Sbjct: 1855 TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLP-GVIVTHV 1913
Query: 842 EAKDVDLGANVSYRIR---SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
DVDL + + +P K FA+ TG + L+++LD+E + E I
Sbjct: 1914 SVHDVDLNSAFIFSFAKESNPGTK--FAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSV 1971
Query: 899 FDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGL 958
G + V V D+ND PPVFS+ Y+ V G + T+ A D +
Sbjct: 1972 HYTEGAL-------VVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESN-- 2022
Query: 959 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR---VNLNEEPTTIFKLVVVAFDDGEPV 1015
+ YR+ + F ++ +G + T + L+ TT F +V A D G P
Sbjct: 2023 --ENISYRILS-----SSKEFSIDPKNGTIFTISPVLLLDTISTTQF--LVEASDGGNPD 2073
Query: 1016 MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIVY 1069
+ + V+I + P FT + Y +SE A G+ + S N + Y
Sbjct: 2074 LRALTLVEIGIEDMNNYAPEFTVKSYNLS-LSEDALVGSTLVTFSNIDHDWTRENTYVEY 2132
Query: 1070 SIVSGNEEDTFGINNI----------TGVIYVNGPLDYETRTSYVLRVQADSLEVVLANL 1119
SI+SGN ++ F + G + + LD E S+ L ++ ++
Sbjct: 2133 SIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASH-------ELVILASDS 2185
Query: 1120 RVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVM 1179
P S+TA + I++ D N++PP F Y V E + + + V A D+DTG+++ +
Sbjct: 2186 GCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEI 2245
Query: 1180 AYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL 1239
Y +I K F +E TG++ + + F V A+D K S A V
Sbjct: 2246 IYNII---SGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAEKKHFS-FAVVF 2301
Query: 1240 VSVVNQLD 1247
VSV++ D
Sbjct: 2302 VSVLDDND 2309
Score = 272 bits (696), Expect = 2e-72
Identities = 281/1075 (26%), Positives = 471/1075 (43%), Gaps = 112/1075 (10%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP--NGQIEYVIQ 192
I V D+ND+SP+F+ E +V E P+GT ++ + D DDG N +I+Y I+
Sbjct: 1043 IDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKD------DDGSFLNSRIQYYIE 1096
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
+ +P +N P G +V RL+ E + + A+D+A N+ +RR + T
Sbjct: 1097 SH--NPGTNPFLIHPSF--GTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQ 1152
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
+ +LD +D P F+ + P E++ + I A D
Sbjct: 1153 IVILDVNDHNPTFI------------------SFPNAHVKEDVTVGSLVHHITAHD---- 1190
Query: 313 IQPPSDRPG-ILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
P R G + YSIL G F + + L+ P++ + + L + A D
Sbjct: 1191 --PDEGRNGKVTYSILSGNEN---MTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDG 1245
Query: 372 GHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDK 431
L + L + +LD N+++P F Y+ + E+ G ++ R+ ALD+
Sbjct: 1246 TPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT---------RVEALDR 1296
Query: 432 DIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQ 488
D + + +F + + TG T+L DRE Q+ +T + DG
Sbjct: 1297 DSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTIL---DREIQEVFTLRVLVRDGGFPS 1353
Query: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
S + V D ND+ P F SYD+ V + P + V + A D D G+N + Y I
Sbjct: 1354 LSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHI 1412
Query: 549 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 607
+ G + F IN+ +G ++ ++ + L + +D P R+S+ + + VL
Sbjct: 1413 IDGNTDECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPP--RSSVIHLQVRVLD 1470
Query: 608 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--DSITYAIENGDPQRVFNLSE 665
N+ S P FP L Y + E VG V+L L A D++ + T + F +
Sbjct: 1471 ANDHS-PSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDP 1529
Query: 666 TTGILTLGKALDRESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPV-----FD 718
+G L LDRE+ ++ A D G+ + TV + VTDVNDN PV FD
Sbjct: 1530 MSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD 1589
Query: 719 PYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKL 777
+L E N V+A D D G NG V +S ++F I G I
Sbjct: 1590 VFLS-----PESPTNQTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNP 1644
Query: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
+ E + + V G P +T L + ++ +D F++ Y LV EN AGT+
Sbjct: 1645 SSEYFPIWLQLKVTDQGI--PARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTS 1702
Query: 838 ILQIEAKDVD-LGANVSYRIRSPEVKHFFALHPFTGELSLL--RSLDYEAFPDQEASITF 894
I+ ++A D + ++ Y I S +L +G+L++ + LD+E E +
Sbjct: 1703 IVTVKAFAPDSIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEV--RNEVQLIV 1760
Query: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
L E+ + V V+++D ND P F + IY+ V+ + + V+A D D
Sbjct: 1761 LAES-----SGHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLD 1815
Query: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
GL + Y + F+++ SG + T+ L+ E T+ + L+V A D G P
Sbjct: 1816 -SGL-NGLIEY---SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMP 1870
Query: 1015 VMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA--AAINQSIVYSI 1071
+S++ +K+ V + P F E ++E + G +V +S +N + ++S
Sbjct: 1871 RLSNTTVIKVQVTDINDNAPAFLPSE--AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF 1928
Query: 1072 VSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQ-ADSLEVVLANLRVPSKSNTAK 1129
+ T F I+ TGV+ + LD+E T Y L +Q +DS+
Sbjct: 1929 AKESNPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQISDSVHY-----------TEGA 1977
Query: 1130 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
+ + + D N++PPVF + FY V E + SVL + ATD ++ ++YR++
Sbjct: 1978 LVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRIL 2030
Score = 257 bits (657), Expect = 6e-68
Identities = 280/1151 (24%), Positives = 494/1151 (42%), Gaps = 132/1151 (11%)
Query: 137 VRDRNDNSPTFKHESYYATV--NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
V D ND++P F SY V N+ V T+ A+D+D G N +EY I
Sbjct: 1364 VEDENDHAPEFIVSSYDIEVLENQEPEVVYTVL--------ASDMDAGNNRAVEYHII-- 1413
Query: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
D +++ F I M +G + + L+ E + + ++I +D + R++ L V
Sbjct: 1414 --DGNTDECFTINEM-SGELSTTRALDREQISNFTLVILCSDLG---DPPRSSVIHLQVR 1467
Query: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
VLD +D P F L YQ+++ R E+ +++ + A+D+D +
Sbjct: 1468 VLDANDHSPSF------------PTLYYQSSV---REDAEVGTVVLV--LSAVDKDEGLN 1510
Query: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQK--FDLVIKAEQDNG 372
++ Y + ++ F + P + L ++R+ + F V + G
Sbjct: 1511 GQTE-----YFLT----DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQG 1561
Query: 373 HPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRIVA 428
+ + + D N+ P + ++ +P T +D L+L +V
Sbjct: 1562 SRSTTVI-IKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVF 1620
Query: 429 LDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ 488
+ + ++ YT Q + Y + + +Q G+
Sbjct: 1621 SFAETQSM------FSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQ-----------GIP 1663
Query: 489 ESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI 548
+ + M+ D +F Y V + G S++ + A A + + Y I
Sbjct: 1664 ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAF-APDSIQDSMKYSI 1722
Query: 549 LVGAQ-GDFIINKTTGLITIAPG--VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
G + G + +G +T+ ++ V L V A + + C V + +
Sbjct: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-----HRAYCKVAVLI 1777
Query: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFN 662
N+ SP F Q +Y +SE+ A ++ + ATD + I Y+I +G+ + F
Sbjct: 1778 QDENDNSPC-FEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQ 1836
Query: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
+ +G++T LD E T Y LI+ A+D G P ++T + + VTD+NDNAP F L
Sbjct: 1837 IDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAF---L 1893
Query: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN---LFRITSNGSIYTAVK-L 777
P + E++ V + D +N +S +N F I N + VK L
Sbjct: 1894 PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTL 1953
Query: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
+ E YEL++ +D +VH ++ L ++VLD++DN PVF+ Y V V E++P G +
Sbjct: 1954 DFEEMTEYELLIQISD-SVH--YTEGALVVRVLDVNDNPPVFSQDFYQVTVPESIPVGYS 2010
Query: 838 ILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
+L + A D++ N+SYRI S + F++ P G + + + D ++ FLVE
Sbjct: 2011 VLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPV---LLLDTISTTQFLVE 2065
Query: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
A D + V + ++DMN+Y P F+ + Y ++ DA+ G+ + T D D
Sbjct: 2066 ASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTR 2125
Query: 958 LPASRVRYRV----DDVQFPYPASIFEVE---EDSGRVITRVNLNEEPTTIFKLVVVAFD 1010
+ V Y + F F E + G ++ +L+ E + +LV++A D
Sbjct: 2126 -ENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASD 2184
Query: 1011 DGEPVMSSSATVKILVLHPGEIP-RFTQEEYRPPPVSELATKGTMVGVISA----AAINQ 1065
G P +SS+A + I VL + P F+ Y V E G+ + V+SA +
Sbjct: 2185 SGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTH-VKESTPLGSHITVVSANDRDTGSHA 2243
Query: 1066 SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1125
I+Y+I+SGNE+ F + TGV+Y+ PLDYE T + L VQA E
Sbjct: 2244 EIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASDAE--------KKHF 2295
Query: 1126 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1185
+ A V++ + D+N+H P F + V E+ + +++ + A D D G Y + Y ++
Sbjct: 2296 SFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVS 2355
Query: 1186 P-----PIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
P + + F+++ TG I + + + V A D K D
Sbjct: 2356 PCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD--------KGDATA 2407
Query: 1241 SVVNQLDMQVI 1251
S+V +D++ I
Sbjct: 2408 SLVVWVDIEGI 2418
Score = 240 bits (612), Expect = 1e-62
Identities = 291/1169 (24%), Positives = 476/1169 (40%), Gaps = 151/1169 (12%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
EV I V D NDN P F S +++ TP GT ++ A D D G NG I Y I
Sbjct: 465 EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA-----RAEDRDSGRNGLIRYSI 519
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
+ D L L G++ E+R T TL
Sbjct: 520 ASPQPGVFAIDRALGVLFLNGSL-------------------------GAGEQRELTLTL 554
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
+ + + V++ T++ + ++ E L+P +T +Q Q
Sbjct: 555 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP--MTQMLQT--QAH 610
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA-EQD 370
+ P + YS+ P F + P T + L + + Q ++ + A +
Sbjct: 611 PLGPQRAASPLRYSL---EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 667
Query: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
+G + + + DEN+ SP F + +E +PV + +I A+D
Sbjct: 668 DGFLQNVSTTVIVRVWDENDNSPTF-LHDVLFLKVEESPVPQGVIG--------KITAID 718
Query: 431 KDIEDTKDPELHLFLNDYTSVFTVT-QTGITRYLTLLQPVD-------------REEQQT 476
D K+ +L FL F + TG + ++ D +E Q
Sbjct: 719 MD--SGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQA 776
Query: 477 Y------------------------------TFSITAFDGVQESEPVIVNIQVMDANDNT 506
+ T +T + + V + V D NDN
Sbjct: 777 FVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNR 836
Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLT----AVDADEGSNGEITYEILVGAQGD-FIINKT 561
P FP+ ++ + G V L A D DEG+N E+TY + D F I+
Sbjct: 837 PFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDAN 896
Query: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
G I + +Y ++V A D P + ++ V I+V+ P ++ Q +
Sbjct: 897 NGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAV--VNIQVI-PLSKGRAIMSQNIR 953
Query: 622 SLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNLSETTGILTLGKALD 677
L I E ++ ++ ++++D + ++I D F + +TG L L K LD
Sbjct: 954 HLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELD 1013
Query: 678 RESTDRYILIITASDGRPDGTSTATV--NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF 735
E+T Y+ + +D + + ++TV +I V D ND++P F L V+ E N
Sbjct: 1014 YETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQD----ELIVISVEENVP 1069
Query: 736 VGQV----KATDPDAG-INGQVHYSLGNFN---NLFRI-TSNGSIYTAVKLNREVRDYYE 786
+G + A D D +N ++ Y + + N N F I S G++ T +L+RE
Sbjct: 1070 IGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVI 1129
Query: 787 LVVVATDGAVH---PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843
L V A+D AV+ R +LT I +LD++D++P F S V+E++ G+ + I A
Sbjct: 1130 LTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFI-SFPNAHVKEDVTVGSLVHHITA 1188
Query: 844 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901
D D G N V+Y I S F L +G L+ LDYE + V A D
Sbjct: 1189 HDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYE----MKTQHILTVLALDD 1244
Query: 902 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
T+TV V D+ND PVF + +Y+ V + G +T V A D D S
Sbjct: 1245 GTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRD------S 1298
Query: 962 RVRYRVDDVQFPYPA-SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 1020
V ++ P + +FE+ D+G V+T L+ E +F L V+ D G P +SS+
Sbjct: 1299 GVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTT 1358
Query: 1021 TVKILVLHPGE-IPRFTQEEYRPPPV--SELATKGTMVGVISAAAINQSIVYSIVSGNEE 1077
T+ V + P F Y + E T++ A N+++ Y I+ GN +
Sbjct: 1359 TILCTVEDENDHAPEFIVSSYDIEVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTD 1418
Query: 1078 DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
+ F IN ++G + LD E +++ +L ++ ++L P +S+ + + + D
Sbjct: 1419 ECFTINEMSGELSTTRALDREQISNF-------TLVILCSDLGDPPRSSVIHLQVRVLDA 1471
Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
N+H P F +Y V EDA + T VL + A DKD G Y L E F +
Sbjct: 1472 NDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL----TDEASGAFTI 1527
Query: 1198 ETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
+ +G +KT+ RS F +A D
Sbjct: 1528 DPMSGTLKTSNTLDREARSQHTFSAVARD 1556
Score = 231 bits (590), Expect = 3e-60
Identities = 266/1103 (24%), Positives = 478/1103 (43%), Gaps = 108/1103 (9%)
Query: 103 LDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTP 161
LDR+ P I ++ Q +N + +IV+ D ND++PTF A V E
Sbjct: 1120 LDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFPN-AHVKEDVT 1178
Query: 162 VGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLN 221
VG+ + A D D+G NG++ Y I + N TF + +G + L+
Sbjct: 1179 VGSLVH-----HITAHDPDEGRNGKVTYSILSGNE----NMTFMLDES-SGLLTTTCPLD 1228
Query: 222 YEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
YE KT++ + + A D +++ TLTV VLD +D P+F +
Sbjct: 1229 YEMKTQHILTVLALDDG---TPALSSSQTLTVTVLDVNDEAPVF------------KQHL 1273
Query: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Y+A++ E + P E ++A+D+D + + + I+ G + F ++
Sbjct: 1274 YEASVKENQNPGEF-----VTRVEALDRDSGVNSK-----LQFEIMPGASFE---LFEIN 1320
Query: 342 PRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPSY 400
T E+ ++R+ + F L + +D G P L + + + DEN+ +P F + SY
Sbjct: 1321 SDTGEVVTTTILDREIQEVFTLRVLV-RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSY 1379
Query: 401 QGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGIT 460
+LE+ + ++A D D + + E H+ + FT+ + ++
Sbjct: 1380 DIEVLENQEPEVVYT----------VLASDMDAGNNRAVEYHIIDGNTDECFTINE--MS 1427
Query: 461 RYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
L+ + +DRE+ +T I D S + + ++V+DAND++P+FP + Y V
Sbjct: 1428 GELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSV 1487
Query: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRT 578
D G V+ L+AVD DEG NG+ Y + A G F I+ +G + + ++
Sbjct: 1488 REDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQ 1547
Query: 579 YALTVQAADNAPPAERRNS-ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
+ + A D + R + I VY+ + N + P Q + + +S +
Sbjct: 1548 HTFSAVARDCSIQGSRSTTVIIKVYVTDV---NDNDPVLEQNPFDVFLSPESPTNQTTVI 1604
Query: 638 LQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPD 696
++A D + G + T + Q +F++ + TG + + E ++ + G P
Sbjct: 1605 VRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIPA 1664
Query: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
T+T + ++ + D F +L + L EA + VKA PD+ I + YS+
Sbjct: 1665 RTTTGLL-VIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSI 1722
Query: 757 --GNFNNLFRITSNGSIYTAVK---LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
GN + + + S T + L+ EVR+ +L+V+A + +A+ + D
Sbjct: 1723 FSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG---HRAYCKVAVLIQD 1779
Query: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHP 869
+DNSP F S Y V E+ ++Q+ A D+D G N + Y I S + F +
Sbjct: 1780 ENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDA 1839
Query: 870 FTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF--S 927
+G ++ LDYE +S + +V+A D + V V D+ND P F S
Sbjct: 1840 LSGVITTKAILDYEL----TSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPS 1895
Query: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
+ + + D++ G +T V D D + + P + F +++++G
Sbjct: 1896 EAV---EITEDSLPGVIVTHVSVHDVD------LNSAFIFSFAKESNPGTKFAIDQNTGV 1946
Query: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
V+ L+ E T ++L++ D V + + + VL + P +++ V E
Sbjct: 1947 VVLVKTLDFEEMTEYELLIQISDS---VHYTEGALVVRVLDVNDNPPVFSQDFYQVTVPE 2003
Query: 1048 LATKGTMVGVISAAAI--NQSIVYSIVSGNEEDTFGINNITGVIYVNGP---LDYETRTS 1102
G V +SA + N++I Y I+S ++E F I+ G I+ P LD + T
Sbjct: 2004 SIPVGYSVLTLSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQ 2061
Query: 1103 YVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTS 1162
+++ P V I I+D NN+ P F K Y +SEDA + ++
Sbjct: 2062 FLVEASDGG---------NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
Query: 1163 VLRVKATDKD-TGNYSVMAYRLI 1184
++ D D T + + Y +I
Sbjct: 2113 LVTFSNIDHDWTRENTYVEYSII 2135
Score = 215 bits (547), Expect = 3e-55
Identities = 292/1121 (26%), Positives = 481/1121 (42%), Gaps = 122/1121 (10%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
ST R LDR+ N +++ + ++I+ +VR++ D ND+SP+F Y ++V
Sbjct: 1431 STTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVL--DANDHSPSFPTLYYQSSVR 1488
Query: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
E VGT + A D D+G NGQ EY + D+ + T + ++G +
Sbjct: 1489 EDAEVGTVVLV-----LSAVDKDEGLNGQTEYFLT---DEASGAFTID---PMSGTLKTS 1537
Query: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
L+ E ++++ A D + + R+TT + V V D +D P VL N D
Sbjct: 1538 NTLDREARSQHTFSAVARDCS--IQGSRSTTVIIKVYVTDVNDNDP-----VLEQNPFDV 1590
Query: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
+PE +P T I D D ++ P +++S +
Sbjct: 1591 -----------FLSPE--SPTNQTTVIVRAD-DLDLGPNGT---VVFSFA-----ETQSM 1628
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
F + T E+ + + ++ + L +K D G P GL + ++ + F+
Sbjct: 1629 FSIDKYTGEIQFQQNPSSEYFPIW-LQLKVT-DQGIPARTTTGLLVIHMEGEDVKISFSH 1686
Query: 398 PSYQGYILESAPVGATISDSLNLTSPLRIVALDKD-IEDTKDPELHLFLNDYTSVFTVTQ 456
Y+G + E+ G TS + + A D I+D+ + +F + V ++
Sbjct: 1687 HLYKGLVTENCEAG---------TSIVTVKAFAPDSIQDSM--KYSIFSGNEDGVLSLCS 1735
Query: 457 TGITRYLTLLQP--VDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISY 514
+ LT+ +P +D E + + A + + + + D NDN+P F + Y
Sbjct: 1736 K--SGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYCKVA-VLIQDENDNSPCFEQSIY 1792
Query: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD-FIINKTTGLITIAPGVEM 573
V VIQ+ A D D G NG I Y IL G Q + F I+ +G+IT ++
Sbjct: 1793 QASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTKAILDY 1852
Query: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGA 633
+ +Y+L VQA D P R ++ + ++V N+ +P P ++EI+E G
Sbjct: 1853 ELTSSYSLIVQATDKGMP--RLSNTTVIKVQVTDINDNAPAFLPS--EAVEITEDSLPGV 1908
Query: 634 VLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITA 690
++ ++ D + +S ++A E+ +P F + + TG++ L K LD E Y L+I
Sbjct: 1909 IVTHVSVHDVDLNSAFIFSFAKES-NPGTKFAIDQNTGVVVLVKTLDFEEMTEYELLIQI 1967
Query: 691 SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGING 750
SD V ++ DVNDN PVF + V + ATD ++ N
Sbjct: 1968 SDSVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSATDLES--NE 2023
Query: 751 QVHYSLGNFNNLFRIT-SNGSIYT-AVKLNREVRDYYELVVVATDGAVHPRHSTLTLA-I 807
+ Y + + + F I NG+I+T + L + + +V A+DG +P LTL I
Sbjct: 2024 NISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGG-NPDLRALTLVEI 2082
Query: 808 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSP----- 859
+ D+++ +P FT +Y + + E+ G+T++ D D V Y I S
Sbjct: 2083 GIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNN 2142
Query: 860 ---EVKHFFALHPF--TGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
E K F + +P+ G L LL SLD EA AS ++ A D A +++
Sbjct: 2143 FHVETKFFHSEYPYKQVGYLVLLHSLDREA----SASHELVILASDSGCPPLSSTAVISI 2198
Query: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
V D+ND PP FS Y V G+ IT V A D D G A + + + +
Sbjct: 2199 QVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDT-GSHAEIIYNIISGNEKGH 2257
Query: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IP 1033
F +EE++G + L+ E T F L V A D E S A V + VL + P
Sbjct: 2258 ----FYLEENTGVLYLIKPLDYEKMTKFTLTVQA-SDAEKKHFSFAVVFVSVLDDNDHAP 2312
Query: 1034 RFTQEEYRPPPVSELATKGTMVGVISA---AAINQSIVYSIVS--------GNEEDTFGI 1082
+F + L T+ + + A + YSIVS + D F I
Sbjct: 2313 QFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLI 2372
Query: 1083 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1142
+ +TG I+ LDYE Y L VQA A+L V+++I+ + P
Sbjct: 2373 DPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASL---------VVWVDIEGIDEFEP 2423
Query: 1143 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
+F + Y + E + + RV+A+D D G V+ Y L
Sbjct: 2424 IFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL 2464
Score = 214 bits (544), Expect = 7e-55
Identities = 294/1146 (25%), Positives = 479/1146 (41%), Gaps = 130/1146 (11%)
Query: 45 AIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLD 104
++ E++ GT+++ + G T E L D +DP+ L T LD
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQT-EYFLTDEASGAFTIDPMSGTL---KTSNTLD 1541
Query: 105 RDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVG 163
R+ + S V + I T + +++ V D NDN P + + ++ +P
Sbjct: 1542 REARSQHTFSAVARDCSIQGSRSTTVI--IKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
Query: 164 -TTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNY 222
TT+ A D+D GPNG + + + F I TG I ++ +
Sbjct: 1600 QTTVIVR------ADDLDLGPNGTVVFSFA------ETQSMFSID-KYTGEIQFQQNPSS 1646
Query: 223 EDKTRYFVI-IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLT 281
E YF I +Q Q + R TTT L V ++G+D+ F +
Sbjct: 1647 E----YFPIWLQLKVTDQGIPAR--TTTGLLVIHMEGEDVKISFSHHL------------ 1688
Query: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMH 341
Y+ + E E IVT A P S + + YSI G + +
Sbjct: 1689 YKGLVTENC---EAGTSIVTVKAFA--------PDSIQDSMKYSIFSGNEDGV---LSLC 1734
Query: 342 PRTAELSLLEPVNRDFH--QKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPS 399
++ +L++ EP DF + L++ AE +GH A+ + + I DEN+ SP F
Sbjct: 1735 SKSGQLTVKEPKFLDFEVRNEVQLIVLAES-SGHR--AYCKVAVLIQDENDNSPCFEQSI 1791
Query: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
YQ + ES A + +++ A D D E + + F + +
Sbjct: 1792 YQASVSESQLYNAHV---------IQVFATDLDSGLNGLIEYSILSGNQEEAFQID--AL 1840
Query: 460 TRYLTLLQPVDREEQQTYTFSITAFD-GVQE-SEPVIVNIQVMDANDNTPTFPEISYDVY 517
+ +T +D E +Y+ + A D G+ S ++ +QV D NDN P F S V
Sbjct: 1841 SGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLP-SEAVE 1899
Query: 518 VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGR 577
+ D PG V ++ D D S ++ F I++ TG++ + ++
Sbjct: 1900 ITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959
Query: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Y L +Q +D+ E + + VL N+ +PP F Q Y + + E++ VG +L
Sbjct: 1960 EYELLIQISDSVHYTEG-----ALVVRVLDVND-NPPVFSQDFYQVTVPESIPVGYSVLT 2013
Query: 638 LQATDREG-DSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTDRYILIITASDG-R 694
L ATD E ++I+Y I + + F++ G I T+ L ++ ++ ASDG
Sbjct: 2014 LSATDLESNENISYRILSSSKE--FSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGN 2071
Query: 695 PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKAT----DPD-AGIN 749
PD + V I + D+N+ AP F NLS+ E+ A VG T D D N
Sbjct: 2072 PDLRALTLVEIGIEDMNNYAPEFT-VKSYNLSLSED---ALVGSTLVTFSNIDHDWTREN 2127
Query: 750 GQVHYSL--GNFNNLFRITSN-----------GSIYTAVKLNREVRDYYELVVVATDGAV 796
V YS+ GN N F + + G + L+RE +ELV++A+D
Sbjct: 2128 TYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGC 2187
Query: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSY 854
P ST ++I+VLD++DN P F++ +Y V+E+ P G+ I + A D D G A + Y
Sbjct: 2188 PPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSANDRDTGSHAEIIY 2247
Query: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTV 914
I S K F L TG L L++ LDYE + T V+A D A V V
Sbjct: 2248 NIISGNEKGHFYLEENTGVLYLIKPLDYE----KMTKFTLTVQASDA-EKKHFSFAVVFV 2302
Query: 915 IVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF-- 972
V D ND+ P F + +V + + I ++ A D D P + Y + F
Sbjct: 2303 SVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAG--PYGELTYSIVSPCFLT 2360
Query: 973 ---PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP 1029
Y +F ++ +G + + L+ E + L V A D G+ S V I +
Sbjct: 2361 HGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDATASLVVWVDIEGIDE 2420
Query: 1030 GEIPRFTQEEY---RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNIT 1086
E P FTQ++Y P + G + + A I+ I+YS+ G F +N
Sbjct: 2421 FE-PIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSL--GTSSPFFSVNKTN 2477
Query: 1087 GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP--VF 1144
G IY+ L S + + ++++ + + SK + V++ + + P VF
Sbjct: 2478 GNIYLIRAL--PLIKSQLNKEDTLEMKIIAHSPKSDSKFASCTVFVNVSFSSEGTPLAVF 2535
Query: 1145 QKKFYI 1150
F I
Sbjct: 2536 ASSFSI 2541
Score = 212 bits (539), Expect = 3e-54
Identities = 303/1254 (24%), Positives = 516/1254 (41%), Gaps = 177/1254 (14%)
Query: 30 DDCKLARGGPPATIV----AIDEES-RNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYW 84
D+ ++++ PP T + A D +S RNG LI+ + P P +
Sbjct: 485 DEIRISQTTPPGTALYLARAEDRDSGRNG-------LIRYSIASPQPGV----------- 526
Query: 85 VLMDPVKQMLFLN-STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
+D +LFLN S G R+ + + + + Q ++ + ++ VV ++ ++
Sbjct: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRA---EDQGVHPQAALLVL----TVVIEKREH 579
Query: 144 SP--TFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTS 200
SP TF+H Y V+E L+P+ + T GP + ++Y+ +
Sbjct: 580 SPSWTFEHLVYQVEVSESLSPMTQMLQTQAH--------PLGPQ-RAASPLRYSLEPSVD 630
Query: 201 NDTFEIPLMLTGNIVLRKRLNYEDKTRY----FVIIQANDRAQNLNERRTTTTTLTVDVL 256
+ F I TG I LR++ +YE Y F I + QN++ TT+ V V
Sbjct: 631 SAMFGIR-PYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS------TTVIVRVW 683
Query: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR----- 311
D +D P FL VL L+ E P V I AID D
Sbjct: 684 DENDNSPTFLHDVLF-----------------LKVEESPVPQGVIGKITAIDMDSGKNGQ 726
Query: 312 ------------NIQPPSDRPGILYSI--------LVGT----PEDYPRFFHMHPRTAEL 347
+ P + G +Y I GT D + F + EL
Sbjct: 727 LLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCEL 786
Query: 348 SLLEPVN-----RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYF--TMPSY 400
E +N R+ ++ + P A +++ + D N+ P+F +P
Sbjct: 787 GEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGK 846
Query: 401 QGY--ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQT 457
+ + +LE PV ++ + A D D + + + D + F +
Sbjct: 847 ELHVKVLEGQPVNMLVT---------TVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANN 897
Query: 458 GITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE-PVIVNIQVMDANDNTPTFPEISYD 515
G R T+L + + +Y S+ A D GV + +VNIQV+ + +
Sbjct: 898 GEIRTTTIL---SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRH 954
Query: 516 VYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEILV-GAQGDFIINKTTGLITIAPGVEM 573
+ + +++P + + + D + NG++ + I+ G F I+ +TG + ++ ++
Sbjct: 955 LIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDY 1014
Query: 574 IVGRTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEISEAMRVG 632
Y V D+ ++ + TV++ + + N P F + + + E + +G
Sbjct: 1015 ETTSHYLFRVITTDH---SKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIG 1071
Query: 633 AVLLNLQATDREG----DSITYAIENGDP-QRVFNLSETTGILTLGKALDRESTDRYILI 687
++ A D +G I Y IE+ +P F + + G L LDRES IL
Sbjct: 1072 TLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILT 1131
Query: 688 ITASDGRPDGTS----TATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKAT 742
+TASD + T + T IV+ DVND+ P F + N V E+ + V + A
Sbjct: 1132 VTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF--PNAHVKEDVTVGSLVHHITAH 1189
Query: 743 DPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 799
DPD G NG+V YS+ GN N F + S+G + T L+ E++ + L V+A D
Sbjct: 1190 DPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPAL 1249
Query: 800 HSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIR 857
S+ TL + VLD++D +PVF Y V+EN G + ++EA D D G N + + I
Sbjct: 1250 SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIM 1309
Query: 858 SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI-- 915
F ++ TGE+ L D+E F + G P +T T++
Sbjct: 1310 PGASFELFEINSDTGEVVTTTIL------DREIQEVFTLRVLVRDGGFPSLSSTTTILCT 1363
Query: 916 VKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYP 975
V+D ND+ P F Y V + + + TV A D D A V Y + D
Sbjct: 1364 VEDENDHAPEFIVSSYDIEVLENQ-EPEVVYTVLASDMDAGNNRA--VEYHIIDGN---T 1417
Query: 976 ASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRF 1035
F + E SG + T L+ E + F LV++ D G+P SS +++ VL +
Sbjct: 1418 DECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPS 1477
Query: 1036 TQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYV 1091
Y V E A GT+V V+SA +N Y ++ F I+ ++G +
Sbjct: 1478 FPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTLKT 1536
Query: 1092 NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG 1151
+ LD E R+ + A + S+S T + + + D N++ PV ++ +
Sbjct: 1537 SNTLDREARSQHTFSAVARDCSI------QGSRSTTVIIKVYVTDVNDNDPVLEQNPFDV 1590
Query: 1152 GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIK 1205
+S ++ + + V+A D D G + + E + F ++ YTG I+
Sbjct: 1591 FLSPESPTNQTTVIVRADDLDLGPNGTVVF-----SFAETQSMFSIDKYTGEIQ 1639
Score = 199 bits (505), Expect = 2e-50
Identities = 242/962 (25%), Positives = 390/962 (40%), Gaps = 119/962 (12%)
Query: 363 LVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
L++ A+ G A + I I F P Y + E P S
Sbjct: 345 LMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPED----------S 394
Query: 423 PLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSI 481
P+ V + + ++ + D F++ + G R +P+D E Q ++
Sbjct: 395 PIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIR---TRKPLDHETQPVVVLTV 451
Query: 482 TAFDGVQES-EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGS 540
A G + VNI VMD NDN P F S ++ + PG ++ A D D G
Sbjct: 452 QAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 511
Query: 541 NGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
NG I Y I G F I++ G++ + + R LT++A D + + T
Sbjct: 512 NGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLT 571
Query: 601 VYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGAVLLNLQA----TDREGDSITYAIENG 655
V IE SP F L+Y +E+SE++ +L QA R + Y++E
Sbjct: 572 VVIE---KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPS 628
Query: 656 DPQRVFNLSETTGILTLGKALDRESTDRYILIITA---SDGRPDGTSTATVNIVVTDVND 712
+F + TG + L + D EST Y + A DG ST TV + V D ND
Sbjct: 629 VDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDEND 687
Query: 713 NAPVFDPYLPRNLSVVEEEA---NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN- 768
N+P F L L + EE+ +G++ A D D+G NGQ+ Y L + F++ N
Sbjct: 688 NSPTF---LHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNT 744
Query: 769 ---GSIYTA-----------------------------------------VKLNREVRDY 784
G+IY V L+RE R +
Sbjct: 745 GPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGH 804
Query: 785 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQ 840
+E+ V+ TD PR++T+ + + V DI+DN P F V V E P +
Sbjct: 805 HEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTT 864
Query: 841 IEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
+ AKD D G A V+Y + S + F + GE+ L Y+ P S+ +
Sbjct: 865 VFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQG 924
Query: 899 FDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP 956
+PP G A V + V ++ + S+ I + ++ P+ +K T I ++
Sbjct: 925 ------VPPLQGQAVVNIQVIPLSKGRAIMSQNI-RHLIIPENLKPTKIMSLIKSSDHLQ 977
Query: 957 GLPASRVRYRV--DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
++ + + DD FE++ +G + L+ E T+ + V+ D +
Sbjct: 978 QHYNGKLHFSIVADDKD-----GHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKN 1032
Query: 1015 V-MSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA-----AAINQSIV 1068
+ +SS+ + I V + Q+E V E GT+V V +A + +N I
Sbjct: 1033 LSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQ 1092
Query: 1069 YSIVSGNE-EDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1127
Y I S N + F I+ G + LD E+ + +L V A V + + R+ +S T
Sbjct: 1093 YYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRL--RSLT 1150
Query: 1128 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1187
A+ I I D N+H P F F V ED + + V + A D D G + Y ++
Sbjct: 1151 AQ--IVILDVNDHNPTF-ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSIL--- 1204
Query: 1188 IKEGKEG--FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQ 1245
G E F+++ +GL+ T ++ V+A DD LS + V+V++
Sbjct: 1205 --SGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDV 1262
Query: 1246 LD 1247
D
Sbjct: 1263 ND 1264
Score = 188 bits (477), Expect = 4e-47
Identities = 254/1092 (23%), Positives = 453/1092 (41%), Gaps = 126/1092 (11%)
Query: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
+P + I Y I G D F +HPR + +P++ + L ++A+ +
Sbjct: 403 EPLNSSEPIFYRISSG---DLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
Query: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
P + ++I ++D N+ P F S + I ++ P G + +A +D
Sbjct: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL-----------YLARAEDR 507
Query: 434 EDTKDPELHLFL-NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD-GVQESE 491
+ ++ + + + VF + + L L + EQ+ T ++ A D GV
Sbjct: 508 DSGRNGLIRYSIASPQPGVFAIDRA--LGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQA 565
Query: 492 PVIVNIQVMDANDNTP--TFPEISYDVYVYTDMRPGDSVIQLTAVD-ADEGSNGEITYEI 548
++V V++ +++P TF + Y V V + P ++Q A + + + Y +
Sbjct: 566 ALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSL 625
Query: 549 LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP 607
F I TG I + + +TY V A +N TV + V
Sbjct: 626 EPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI-PEDGFLQNVSTTVIVRVWD 684
Query: 608 PNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIENGDPQRVFNL 663
N+ SP +++ L++ E+ V+ + A D + G + + + +G + F +
Sbjct: 685 ENDNSPTFLHDVLF-LKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDG---KFFKM 740
Query: 664 SETTG------ILT-------------------------------LGK-------ALDRE 679
+ TG ++T LG+ ALDRE
Sbjct: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
Query: 680 STDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLP---RNLSVVE-EEANA 734
+ + + +D G P +T V + VTD+NDN P F LP ++ V+E + N
Sbjct: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNM 860
Query: 735 FVGQVKATDPDAGINGQVHYSLG--NFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVA 791
V V A DPD G N +V YS+ + ++ F+I +NG I T L+ + R Y + V+A
Sbjct: 861 LVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIA 920
Query: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD---VDL 848
TD V P + I+V+ + + + + +++ ENL + I++ D
Sbjct: 921 TDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHY 980
Query: 849 GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-P 907
+ + I + + F + TG+L L + LDYE + F V D +
Sbjct: 981 NGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYET----TSHYLFRVITTDHSKNLSLS 1036
Query: 908 GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV 967
+++ V+D ND+ P F + V + GT + A+D D L SR++Y +
Sbjct: 1037 STVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFL-NSRIQYYI 1095
Query: 968 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS---SSATVKI 1024
+ + F + G ++T L+ E L V A D V S T +I
Sbjct: 1096 E--SHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQI 1153
Query: 1025 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDT 1079
++L + P F + V E T G++V I+A N + YSI+SGNE T
Sbjct: 1154 VILDVNDHNPTFI--SFPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMT 1211
Query: 1080 FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENN 1139
F ++ +G++ PLDYE +T ++L V A + P+ S++ + + + D N+
Sbjct: 1212 FMLDESSGLLTTTCPLDYEMKTQHILTVLA-------LDDGTPALSSSQTLTVTVLDVND 1264
Query: 1140 HPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVET 1199
PVF++ Y V E+ V RV+A D+D+G S + + I+P E F + +
Sbjct: 1265 EAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFE-IMP--GASFELFEINS 1321
Query: 1200 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTL 1259
TG + T + + F +V+ D LS +L +V ++ D + P +
Sbjct: 1322 DTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEND------HAPEFI 1375
Query: 1260 VEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ--T 1317
V D+ E+L+ E + G R + ++ T T+ + + T
Sbjct: 1376 VSS--YDI-EVLENQEPEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELST 1432
Query: 1318 NRAIDRNELFKF 1329
RA+DR ++ F
Sbjct: 1433 TRALDREQISNF 1444
Score = 136 bits (342), Expect = 2e-31
Identities = 193/817 (23%), Positives = 327/817 (40%), Gaps = 102/817 (12%)
Query: 462 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVI--VNIQVMDANDNTPTFPEISYDVYVY 519
YLTL P+ E T + ++A DG + + V I + F Y VY
Sbjct: 330 YLTL--PLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
Query: 520 TDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRT 578
D+ P DS I S+ I Y I G G F I+ G I ++
Sbjct: 388 EDV-PEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPV 446
Query: 579 YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNL 638
LTVQA + PA + ++V N + P F + + IS+ G L
Sbjct: 447 VVLTVQAQLGSAPACSSTEVNITVMDV----NDNHPAFLRTSDEIRISQTTPPGTALYLA 502
Query: 639 QATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRP 695
+A DR+ I Y+I + P VF + G+L L +L L + A D
Sbjct: 503 RAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV 561
Query: 696 DGTSTATVNIVVTDVNDNAP-------VFDPYLPRNLS----VVEEEANAFVGQVKATDP 744
+ V VV + +++P V+ + +LS +++ +A+ +G +A P
Sbjct: 562 HPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP-LGPQRAASP 620
Query: 745 DAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYYELVVVA---TDGAVHP 798
+ YSL + +F I G IY + + E Y V A DG +
Sbjct: 621 -------LRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFL-- 671
Query: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
++ + T+ ++V D +DNSP F + + VEE+ I +I A D+D G N
Sbjct: 672 QNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 731
Query: 859 PEVKHFFALHPFTGELSLLRSLDYE-----------AFPDQEASITFLVEAFDIYGT--- 904
FF ++P TG + + + AF E L F G
Sbjct: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
Query: 905 ------------------------MPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPD 938
PP AT+ V V D+ND P F + + +
Sbjct: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
Query: 939 AVKGTP----ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNL 994
++G P +TTV+A+D D + V Y V + F+++ ++G + T L
Sbjct: 852 VLEGQPVNMLVTTVFAKDPDEGN--NAEVTYSVSSED---SSDHFKIDANNGEIRTTTIL 906
Query: 995 NEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
+ + +++ V+A D G P + A V I V+ + + R + E +
Sbjct: 907 SYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKI 966
Query: 1055 VGVISAA-----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
+ +I ++ N + +SIV+ +++ F I++ TG ++++ LDYET + Y+ RV
Sbjct: 967 MSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRV-- 1024
Query: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
+ + + S S+T + I+++D+N+H P FQ + + V E+ + T V A
Sbjct: 1025 ----ITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAK 1080
Query: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKT 1206
D D G++ + I G F++ G + T
Sbjct: 1081 D-DDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVT 1116
Score = 130 bits (326), Expect = 1e-29
Identities = 209/902 (23%), Positives = 367/902 (40%), Gaps = 137/902 (15%)
Query: 467 QPVDRE-EQQTYTFSITAFDGVQE------------SEPVIVNIQVMDANDNTPTFPEIS 513
Q +DRE + TY + A DG ++ S V + + D NDN P F +
Sbjct: 122 QDIDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPST 181
Query: 514 YDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVE 572
Y + + +PG +I + A D D G G + YE++ G F I+ TTGL +P VE
Sbjct: 182 YVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--YSPEVE 239
Query: 573 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM-YSLEISEAMRV 631
++ ++ + ++ E + + +V + +F + + +
Sbjct: 240 ILSAVNFSADKEVMNS---LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHL 296
Query: 632 GAVLLNLQATDREGDSITYAIENGDPQRVFNLSET--TGILTLGKALDRESTDRYILIIT 689
+ + +A +G++ + V NL++ GI+ L L + L+++
Sbjct: 297 HYLKVQDEAASADGEAAA--------RYVANLAKILGEGIIYLTLPLSHLESTTLSLMVS 348
Query: 690 ASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--NAFVGQVK 740
A DG G TA +N VT +F L P+ +V E+ ++ +G VK
Sbjct: 349 AQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVK 400
Query: 741 ATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVH 797
A +P + + Y S G+ F I G+I T L+ E + L V A G+
Sbjct: 401 AREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSA- 458
Query: 798 PRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYR 855
P S+ + I V+D++DN P F ++ + + + P GT + A+D D G N + Y
Sbjct: 459 PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYS 518
Query: 856 IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVI 915
I SP+ FA+ G L L SL ++ +T + A D G P V +
Sbjct: 519 IASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQAALLVLTV 572
Query: 916 VKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQ 971
V + ++ P F +Y+ V+ +P+T + A P P AS +RY ++
Sbjct: 573 VIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLRYSLEP-- 627
Query: 972 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATVKILVLHP 1029
+++F + +G + R + E T + V A+ +DG + + S TV + V
Sbjct: 628 -SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDE 685
Query: 1030 GE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGI 1082
+ P F + E P P + G + + + N ++Y ++S + F +
Sbjct: 686 NDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDGK--FFKM 740
Query: 1083 NNIT---GVIYV-------------NGPLDYETRTSYVLR--------------VQAD-- 1110
N T G IYV + + ++VL+ V D
Sbjct: 741 NPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDRE 800
Query: 1111 -----SLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ-----KKFYIGGVSEDARMF 1160
+ V++ + P ++ T VY+ + D N++ P F K+ ++ V E +
Sbjct: 801 HRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVN 859
Query: 1161 TSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKF 1220
V V A D D GN + + Y + ++ + F ++ G I+T + R ++
Sbjct: 860 MLVTTVFAKDPDEGNNAEVTYSV---SSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRM 916
Query: 1221 QVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN------VPPTLVEKKIEDLTEILDRY 1274
VIATD L G+A V + V+ + I+S +P L KI L + D
Sbjct: 917 SVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHL 976
Query: 1275 VQ 1276
Q
Sbjct: 977 QQ 978
Score = 112 bits (279), Expect = 4e-24
Identities = 166/707 (23%), Positives = 278/707 (39%), Gaps = 104/707 (14%)
Query: 530 QLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITIAPGVEMIVG-RTYALTV 583
++TA DAD G G I Y + G A F I+ G I ++ ++ TY L V
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
Query: 584 QAADNAPPAERRNSICTV--------YIEV-LPPNNQSPPRFPQLMYSLEISEAMRVGAV 634
+A D +R + V ++ V L N + P F Y IS+ + G
Sbjct: 138 EAKDG--DEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTE 195
Query: 635 LLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITAS 691
++N+ ATD++ ++ Y + G+ +F + TTG+ +
Sbjct: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYS-------------------- 235
Query: 692 DGRPDGTSTATVNIVVT-DVNDNAPVFDPYLPRNLSVVEEEANA--------------FV 736
P+ + VN +V ++ +F P L R+ VE + A F
Sbjct: 236 ---PEVEILSAVNFSADKEVMNSLEMFLPLL-RHFKKVERDEEAAEKKFEASRGWFMRFK 291
Query: 737 GQ-----VKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVA 791
G+ +K D A +G+ + NL +I G IY + L+ L+V A
Sbjct: 292 GRRHLHYLKVQDEAASADGEA--AARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSA 349
Query: 792 TDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD-VDLGA 850
DG + I + F YT LV E++P + I ++A++ ++
Sbjct: 350 QDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSE 409
Query: 851 NVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 910
+ YRI S ++ F++HP G + + LD+E P + V+A G+ P +
Sbjct: 410 PIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQP----VVVLTVQAQ--LGSAPACSS 463
Query: 911 T-VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPP--GLPASRVRYRV 967
T V + V D+ND P F + + ++ GT + AED D GL +RY +
Sbjct: 464 TEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL----IRYSI 519
Query: 968 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVL 1027
Q +F ++ G + +L L + A D G ++ + +++
Sbjct: 520 ASPQ----PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIE 575
Query: 1028 HPGEIPRFTQE---------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEED 1078
P +T E E P L T+ +G AA+ + YS+ +
Sbjct: 576 KREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS---PLRYSLEPSVDSA 632
Query: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLE-VVLANLRVPSKSNTAKVYIEIQDE 1137
FGI TG IY+ DYE+ +Y RV A E L N+ + V + + DE
Sbjct: 633 MFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV-------STTVIVRVWDE 685
Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1184
N++ P F V E + ++ A D D+G + Y L+
Sbjct: 686 NDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 732
Score = 57.4 bits (137), Expect = 1e-07
Identities = 46/173 (26%), Positives = 81/173 (46%), Gaps = 7/173 (4%)
Query: 1035 FTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
F +E PV E + I S+ +S F I+ G I V+
Sbjct: 64 FRSQEENAKPVKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
Query: 1095 LDYETR-TSYVLRVQA-DSLEVVLANLRVPSKSNTAKVYI--EIQDENNHPPVFQKKFYI 1150
+D E +Y L V+A D E + +L + +A+ ++ +++D N++ PVF Y+
Sbjct: 124 IDRERDPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYV 183
Query: 1151 GGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1203
+S++ + T ++ V ATD+D+G Y +AY LI + F +++ TGL
Sbjct: 184 TSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV---SSLFTIDSTTGL 233
Score = 36.2 bits (82), Expect = 0.28
Identities = 20/57 (35%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
VR+ + D NDN P F +Y ++++ T GT I ATD D G G + Y
Sbjct: 163 VRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVL-----ATDQDSGIYGTVAY 214
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 278 bits (712), Expect = 2e-74
Identities = 252/924 (27%), Positives = 416/924 (45%), Gaps = 77/924 (8%)
Query: 282 YQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPG-ILYSILVGTPEDYPRFFHM 340
YQ +PE N T ++ + QD P + G ++YS+ F +
Sbjct: 330 YQTLVPE-------NEAAGTAVLRVVAQD----PDAGEAGRLVYSLAALMNSRSLELFSI 378
Query: 341 HPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHP-LPAFAGLHIEILDENNQSPYFTMPS 399
P++ + ++R+ ++ L + A QD+G P L A + + + D N+ SP F
Sbjct: 379 DPQSGLIRTAAALDRESMERHYLRVTA-QDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 400 YQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGI 459
Y+ + E+ G I L++ A D D + I
Sbjct: 438 YRETLRENVEEGYPI---------LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI 488
Query: 460 TRYLTLLQP---VDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEI 512
L+ VDRE ++Y + A D QE P V V+I V+D NDN P F E
Sbjct: 489 DPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
Query: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGV 571
Y V D+RP V+++TA D D+ +NG + Y I+ G ++G F I+ TG I + +
Sbjct: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPL 608
Query: 572 EMIVGRTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
+ R YAL ++A D PP + ++ + + N P F + + + E
Sbjct: 609 DFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDI---NDHIPIFVSTPFQVSVLENAP 665
Query: 631 VGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILI 687
+G ++++QA D E + Y++ P F ++ TG +++ LDRES + Y
Sbjct: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
Query: 688 ITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDA 746
+ A D G P +++A+V + V DVNDN P F + + E+A V T D
Sbjct: 726 VEARDHGSPPLSASASVTVTVLDVNDNRPEFT--MKEYHLRLNEDAAVGTSVVSVTAVDR 783
Query: 747 GINGQVHYSL--GNFNNLFRITSNGS---IYTAVKLNREVRDYYELVVVATDGAVHPRHS 801
N + Y + GN N F I++ G + A+ L+ + Y++LV+ A+D A+H
Sbjct: 784 DANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH-- 841
Query: 802 TLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEV 861
+ I + D + + PVF ++ Y+V V E+ P G+TI+ I A D D+G N +
Sbjct: 842 -CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDN 900
Query: 862 KHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMND 921
F + +G ++L LDYE + + T + A D V V+V D+ND
Sbjct: 901 LPQFRIDADSGAITLQAPLDYE----DQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
Query: 922 YPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEV 981
P F Y G+V+ DA T + + A D D RV+Y + + F +
Sbjct: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHA--NGRVQYTFQNGE--DGDGDFTI 1012
Query: 982 EEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEY 1040
E SG V T L+ E ++++L A D G P + + +++++V + P F EE+
Sbjct: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF 1072
Query: 1041 RPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLD 1096
V E + G++V I+A N I+Y IV GN + F ++ +G + LD
Sbjct: 1073 E-VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
Query: 1097 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQ--KKFYIGGVS 1154
YE R YV+ VQA S +V + A V++ + D+N++ PV + + VS
Sbjct: 1132 YEARQEYVIVVQATSAPLV----------SRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
Query: 1155 EDARMFTS--VLRVKATDKDTGNY 1176
+ F S + R+ A D D ++
Sbjct: 1182 NRSDTFPSGIIGRIPAYDPDVSDH 1205
Score = 274 bits (701), Expect = 5e-73
Identities = 246/817 (30%), Positives = 381/817 (46%), Gaps = 87/817 (10%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V DRND+SP F+ Y T+ E G I ATD D PN + Y
Sbjct: 419 VAVTVADRNDHSPVFEQAQYRETLRENVEEGYPIL-----QLRATDGDAPPNANLRYRFV 473
Query: 193 YNPDD-PTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
P + FEI +G I R++ E Y ++++A+D+ Q R + T +
Sbjct: 474 GPPAARAAAAAAFEIDPR-SGLISTSGRVDREHMESYELVVEASDQGQEPGPR-SATVRV 531
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
+ VLD +D P F V R E++ P V + A D+D+
Sbjct: 532 HITVLDENDNAPQFSEKRYVAQVR-----------------EDVRPHTVVLRVTATDRDK 574
Query: 312 NIQPPSDRPGIL-YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
D G++ Y+I+ G + F + T E+ ++ P++ + +++ L I+A+
Sbjct: 575 ------DANGLVHYNIISGNSRGH---FAIDSLTGEIQVVAPLDFEAEREYALRIRAQDA 625
Query: 371 NGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
PL GL I+++D N+ P F +Q +LE+AP+G ++ + I A+
Sbjct: 626 GRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV---------IHIQAV 676
Query: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE 489
D D + E L + F + T ++++ P+DRE + Y F + A D
Sbjct: 677 DADHGENARLEYSLTGVAPDTPFVINSA--TGWVSVSGPLDRESVEHYFFGVEARDHGSP 734
Query: 490 --SEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
S V + V+D NDN P F Y + + D G SV+ +TAVD D +N I+Y+
Sbjct: 735 PLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQ 792
Query: 548 ILVG-AQGDFIINKT--TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
I G + F I+ GL+T+A ++ R + L + A+D A + C V+I
Sbjct: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-----LHDHCYVHIN 847
Query: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 661
+ N P F YS+ ++E +G+ ++ + A+D E ITY +E+ PQ F
Sbjct: 848 ITDANTHRPV-FQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNLPQ--F 904
Query: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPY 720
+ +G +TL LD E Y L ITA D G P T V ++V DVNDNAP F
Sbjct: 905 RIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQF--V 962
Query: 721 LPRNLSVVEEEANAFVG--QVKATDPDAGINGQVHYSLGNFNNL---FRIT-SNGSIYTA 774
+V E+A F Q+ ATD DA NG+V Y+ N + F I ++G + T
Sbjct: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
Query: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
+L+RE YEL A D V P + +++ + V D++DN+PVF + V V+EN
Sbjct: 1023 RRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIV 1082
Query: 835 GTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASI 892
G+ + QI A D D G A++ Y+I + F + F+GEL+ L LDYEA QE I
Sbjct: 1083 GSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEA--RQEYVI 1140
Query: 893 TFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFS 927
+ T P ++ TV V+ D ND PV +
Sbjct: 1141 V-------VQATSAPLVSRATVHVRLVDQNDNSPVLN 1170
Score = 249 bits (637), Expect = 1e-65
Identities = 256/977 (26%), Positives = 433/977 (44%), Gaps = 89/977 (9%)
Query: 145 PTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTF 204
P F +Y V E GT + A D D G G++ Y + + S + F
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVV-----AQDPDAGEAGRLVYSLAALMNS-RSLELF 376
Query: 205 EIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPM 264
I +G I L+ E R+++ + A D + R + TT + V V D +D P+
Sbjct: 377 SIDPQ-SGLIRTAAALDRESMERHYLRVTAQDHG---SPRLSATTMVAVTVADRNDHSPV 432
Query: 265 FLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILY 324
F Y+ + E EE PI+ ++A D D PP+ L
Sbjct: 433 F------------EQAQYRETLRE--NVEEGYPIL---QLRATDGDA---PPNAN---LR 469
Query: 325 SILVGTPEDYPRF---FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFA 379
VG P F + PR+ +S V+R+ + ++LV++A P P A
Sbjct: 470 YRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV 529
Query: 380 GLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP 439
+HI +LDEN+ +P F+ Y + E D T LR+ A D+D +
Sbjct: 530 RVHITVLDENDNAPQFSEKRYVAQVRE---------DVRPHTVVLRVTATDRDKDANGLV 580
Query: 440 ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ---ESEPVIVN 496
++ + F + +T + ++ P+D E ++ Y I A D + + + +
Sbjct: 581 HYNIISGNSRGHFAIDS--LTGEIQVVAPLDFEAEREYALRIRAQDAGRPPLSNNTGLAS 638
Query: 497 IQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL-VGAQGD 555
IQV+D ND+ P F + V V + G SVI + AVDAD G N + Y + V
Sbjct: 639 IQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTP 698
Query: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADN-APPAERRNSICTVYIEVLPPNNQSPP 614
F+IN TG ++++ ++ Y V+A D+ +PP S+ ++V N + P
Sbjct: 699 FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDV----NDNRP 754
Query: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDREGDS-ITYAIENGDPQRVFNLSET--TGILT 671
F Y L ++E VG ++++ A DR+ +S I+Y I G+ + F +S G++T
Sbjct: 755 EFTMKEYHLRLNEDAAVGTSVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVT 814
Query: 672 LGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE 731
L LD + + L++TASD +NI TD N + PVF ++SV E+
Sbjct: 815 LALPLDYKQERYFKLVLTASDRALHDHCYVHINI--TDANTHRPVFQS-AHYSVSVNEDR 871
Query: 732 A-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVV 789
+ + + A+D D G N ++ Y L + FRI ++ G+I L+ E + Y L +
Sbjct: 872 PMGSTIVVISASDDDVGENARITYLLEDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAI 931
Query: 790 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 849
A D + + T + + V D++DN+P F S YT LV E+ P T++LQI A D D
Sbjct: 932 TARDNGIPQKADTTYVEVMVNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAH 991
Query: 850 AN--VSYRIRSPEVKHF-FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
AN V Y ++ E F + P +G + +R LD EA E + A+ + +P
Sbjct: 992 ANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELT------AYAVDRGVP 1045
Query: 907 P--GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964
P ++ V+V+D+ND PVF ++ V +++ G+ + + A D D P + +
Sbjct: 1046 PLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEG--PNAHIM 1103
Query: 965 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024
Y++ + P +F+++ SG + ++L+ E + +VV A P++S +
Sbjct: 1104 YQIVEGNIP---ELFQMDIFSGELTALIDLDYEARQEYVIVVQA--TSAPLVSRATVHVR 1158
Query: 1025 LVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAAA-----INQSIVYSIVSGNEEDT 1079
LV P + + G+I ++ + YS GNE
Sbjct: 1159 LVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQL 1218
Query: 1080 FGINNITGVIYVNGPLD 1096
+N +G + ++ LD
Sbjct: 1219 LVVNQTSGELRLSRKLD 1235
Score = 246 bits (629), Expect = 1e-64
Identities = 245/898 (27%), Positives = 413/898 (45%), Gaps = 79/898 (8%)
Query: 390 NQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDP--ELHLFLND 447
N+ P F +YQ + E+ G T+ LR+VA D D + L +N
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAG---------TAVLRVVAQDPDAGEAGRLVYSLAALMNS 370
Query: 448 YT-SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDAN 503
+ +F++ Q+G+ R L DRE + + +TA D + S +V + V D N
Sbjct: 371 RSLELFSIDPQSGLIRTAAAL---DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 427
Query: 504 DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL------VGAQGDFI 557
D++P F + Y + ++ G ++QL A D D N + Y + A F
Sbjct: 428 DHSPVFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFE 487
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
I+ +GLI+ + V+ +Y L V+A+D R++ V+I VL N+ + P+F
Sbjct: 488 IDPRSGLISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNA-PQFS 546
Query: 618 QLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGK 674
+ Y ++ E +R V+L + ATDR+ D+ + Y I +G+ + F + TG + +
Sbjct: 547 EKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVA 606
Query: 675 ALDRESTDRYILIITASD-GRPD-GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
LD E+ Y L I A D GRP +T +I V D+ND+ P+F P +SV+E
Sbjct: 607 PLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIF-VSTPFQVSVLE--- 662
Query: 733 NAFVG----QVKATDPDAGINGQVHYSLGNF--NNLFRITS-NGSIYTAVKLNREVRDYY 785
NA +G ++A D D G N ++ YSL + F I S G + + L+RE ++Y
Sbjct: 663 NAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY 722
Query: 786 ELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845
V A D P ++ ++ + VLD++DN P FT Y + + E+ GT+++ + A D
Sbjct: 723 FFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVD 782
Query: 846 VDLGANVSYRIRSPEVKHFFAL--HPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
D + +SY+I ++ FA+ G ++L LDY+ QE ++ A D
Sbjct: 783 RDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYK----QERYFKLVLTASD--- 835
Query: 904 TMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRV 963
V + + D N + PVF Y V D G+ I + A D D +R+
Sbjct: 836 RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVG--ENARI 893
Query: 964 RYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVK 1023
Y ++D P F ++ DSG + + L+ E + L + A D+G P + + V+
Sbjct: 894 TYLLED-NLPQ----FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVE 948
Query: 1024 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1078
++V + P+F Y VSE A T V ISA A N + Y+ +G + D
Sbjct: 949 VMVNDVNDNAPQFVASHY-TGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGD 1007
Query: 1079 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
F I +G++ LD E + Y L A + VP + + +QD
Sbjct: 1008 GDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-------VDRGVPPLRTPVSIQVMVQDV 1060
Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVV 1197
N++ PVF + + V E++ + + V ++ A D D G + + Y+++ I E F +
Sbjct: 1061 NDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNI---PELFQM 1117
Query: 1198 ETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
+ ++G + + L + R+ Y VI L +A V V +V+Q D +++N
Sbjct: 1118 DIFSGELTALIDLDYEARQEY----VIVVQATSAPLVSRATVHVRLVDQNDNSPVLNN 1171
Score = 233 bits (595), Expect = 9e-61
Identities = 219/756 (28%), Positives = 341/756 (45%), Gaps = 63/756 (8%)
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD----FI 557
A + P FP+ +Y V + G +V+++ A D D G G + Y + F
Sbjct: 318 AANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 558 INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 617
I+ +GLI A ++ + L V A D+ P R S T+ + N P F
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSP---RLSATTMVAVTVADRNDHSPVFE 434
Query: 618 QLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRV-----FNLSETTGI 669
Q Y + E + G +L L+ATD + ++ Y R F + +G+
Sbjct: 435 QAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGL 494
Query: 670 LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVT--DVNDNAPVFDPYLPRNLS 726
++ +DRE + Y L++ ASD G+ G +ATV + +T D NDNAP F R ++
Sbjct: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSE--KRYVA 552
Query: 727 VVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS-NGSIYTAVKLNREV 781
V E+ + V +V ATD D NG VHY++ GN F I S G I L+ E
Sbjct: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEA 612
Query: 782 RDYYELVVVATDGAVHPRHSTLTLA-IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQ 840
Y L + A D P + LA I+V+DI+D+ P+F ++ + V V EN P G +++
Sbjct: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Query: 841 IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEA 898
I+A D D G N + Y + F ++ TG +S+ LD E+ F VEA
Sbjct: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHY----FFGVEA 728
Query: 899 FDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
D +G+ P A+VTV V D+ND P F+ + Y + DA GT + +V A D D
Sbjct: 729 RD-HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDAN- 786
Query: 958 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS 1017
S + Y++ +I + G V + L+ + FKLV+ A D +
Sbjct: 787 ---SAISYQITGGNTRNRFAI-STQGGVGLVTLALPLDYKQERYFKLVLTASDRA---LH 839
Query: 1018 SSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVS 1073
V I + Q + V+E G+ + VISA+ N I Y +
Sbjct: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
Query: 1074 GNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIE 1133
+ F I+ +G I + PLDYE + +Y L + A + +P K++T V +
Sbjct: 900 NLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVM 950
Query: 1134 IQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE 1193
+ D N++ P F Y G VSEDA FTSVL++ ATD+D + Y + G++
Sbjct: 951 VNDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-----TFQNGED 1005
Query: 1194 G---FVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
G F +E +G+++T S ++ A D
Sbjct: 1006 GDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYAVD 1041
Score = 135 bits (339), Expect = 4e-31
Identities = 151/588 (25%), Positives = 259/588 (44%), Gaps = 77/588 (13%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDN P F + Y+ +NE VGT++ + T +D N I Y I
Sbjct: 742 VTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVS-------VTAVDRDANSAISYQIT 794
Query: 193 YNPDDPTSNDTFEIPLML-TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
+ + F I G + L L+Y+ + + +++ A+DRA + + +
Sbjct: 795 GG----NTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH------CYV 844
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
+++ D + P+F + + RP+ + I+V I A D D
Sbjct: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMG--------------STIVV---ISASDDD- 886
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+ I Y + P+ F + + ++L P++ + + L I A +DN
Sbjct: 887 ----VGENARITYLLEDNLPQ-----FRIDADSGAITLQAPLDYEDQVTYTLAITA-RDN 936
Query: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
G P A ++E++ D N+ +P F Y G + E AP TS L+I A
Sbjct: 937 GIPQKADT-TYVEVMVNDVNDNAPQFVASHYTGLVSEDAPP---------FTSVLQISAT 986
Query: 430 DKDIEDTKDPELHLFLN--DYTSVFTVTQT-GITRYLTLLQPVDREEQQTYTFSITAFD- 485
D+D + + F N D FT+ T GI R + L DRE Y + A D
Sbjct: 987 DRDAHANGRVQ-YTFQNGEDGDGDFTIEPTSGIVRTVRRL---DREAVSVYELTAYAVDR 1042
Query: 486 GVQESE-PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
GV PV + + V D NDN P FP ++V V + G V Q+TAVD DEG N I
Sbjct: 1043 GVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHI 1102
Query: 545 TYEILVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYI 603
Y+I+ G + F ++ +G +T ++ + Y + VQA +AP R TV++
Sbjct: 1103 MYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT-SAPLVSR----ATVHV 1157
Query: 604 EVLPPNNQSPPRFP-QLMYSLEISEAMRV--GAVLLNLQATDRE-GDSITYAIENGDPQR 659
++ N+ SP Q++++ +S ++ + A D + D + Y+ E G+ +
Sbjct: 1158 RLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQ 1217
Query: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVV 707
+ +++T+G L L + LD +++T +DG T+ + +V+
Sbjct: 1218 LLVVNQTSGELRLSRKLDNNRPLVASMLVTVTDGLHSVTAQCVLRVVI 1265
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 268 bits (685), Expect = 3e-71
Identities = 245/893 (27%), Positives = 415/893 (46%), Gaps = 81/893 (9%)
Query: 395 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
F MP+YQ + E+ P G I L L + I ++ + + Y + +
Sbjct: 245 FPMPNYQVALFENEPAGTLI---LQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
Query: 455 TQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNIQVMDANDNTPTFPEI 512
T T + +DRE ++T+ + A D S + + V D ND++P F +
Sbjct: 302 TGAVSTDSV-----LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQS 356
Query: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVE 572
Y V ++ G V+ + A D D N + Y +L GA F +N+++G+++ ++
Sbjct: 357 EYRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLD 416
Query: 573 MIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVG 632
Y L V+A D ++ TVYIEV N + P+F + Y +++ E + +
Sbjct: 417 REEAAEYQLLVEANDQGRNPGPLSATATVYIEV-EDENDNYPQFSEQNYVVQVPEDVGLN 475
Query: 633 AVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 689
+L +QATDR+ +I Y+I +G+ F L +GIL + LD E +Y L I
Sbjct: 476 TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
Query: 690 ASDGR--PDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDA 746
A DG P S+ V++ V DVNDN P+F P +V+E + V ++A D D+
Sbjct: 536 AQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSS-PFQATVLENVPLGYPVVHIQAVDADS 594
Query: 747 GINGQVHYSLGNFNNLFR--------------------ITSNGSIYTAVKLNREVRDYYE 786
G N ++HY L + + F S+G I +L+RE ++Y
Sbjct: 595 GENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYS 654
Query: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDV 846
V A D P S+ +++I VLD++DN PVFT TY + + E+ G+++L ++A+D
Sbjct: 655 FGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDR 714
Query: 847 DLGANVSYRIRSPEVKHFFALHPFTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGT 904
D + ++Y++ ++ FAL G ++L LDY+ QE V A D GT
Sbjct: 715 DANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYK----QEQQYVLAVTASD--GT 768
Query: 905 MPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVR 964
A V + V D N + PVF Y V+ D GT I T+ A D D +R+
Sbjct: 769 R-SHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTG--ENARIT 825
Query: 965 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKI 1024
Y + D P F ++ DSG + T + L+ E + L ++A D+G P S + T++I
Sbjct: 826 YVIQD-----PVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
Query: 1025 LVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED- 1078
L+L + P+F + Y+ + E A T + +SA + N ++Y+ G++ D
Sbjct: 881 LILDANDNAPQFLWDFYQ-GSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
Query: 1079 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDE 1137
F I +GVI LD E Y +L + + P+ S + ++ + I D
Sbjct: 940 DFYIEPTSGVIRTQRRLDRENVAVY-------NLWALAVDRGSPTPLSASVEIQVTILDI 992
Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG--KEGF 1195
N++ P+F+K V E+ + + V +++A D D G + + Y+++ EG + F
Sbjct: 993 NDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV-----EGDMRHFF 1047
Query: 1196 VVETYTGLIKTAM-LFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
++ G ++ + L +RR Y V+ L +A V + +V+Q D
Sbjct: 1048 QLDLLNGDLRAMVELDFEVRREY----VLVVQATSAPLVSRATVHILLVDQND 1096
Score = 265 bits (677), Expect = 3e-70
Identities = 244/864 (28%), Positives = 392/864 (45%), Gaps = 105/864 (12%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
ST VLDR+ V V Y + ++V+D ND+SP F+ Y V
Sbjct: 306 STDSVLDRETKETHVLRVKAVDYSTPPRSATTY--ITVLVKDTNDHSPVFEQSEYRERVR 363
Query: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
E VG + T A+D D N + Y + + D F++ +G + R
Sbjct: 364 ENLEVGYEVLT-----IRASDRDSPINANLRYRVLGG-----AWDVFQLN-ESSGVVSTR 412
Query: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
L+ E+ Y ++++AND+ +N + T T+ ++V D +D P F V
Sbjct: 413 AVLDREEAAEYQLLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYV------ 465
Query: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
++ PE++ +QA D+D+ I YSIL G
Sbjct: 466 -----------VQVPEDVGLNTAVLRVQATDRDQ-----GQNAAIHYSILSGNVAGQ--- 506
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAG-LHIEILDENNQSPYFT 396
F++H + L ++ P++ + QK+ L IKA+ PL +G + +++LD N+ P F
Sbjct: 507 FYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFV 566
Query: 397 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
+Q +LE+ P+G + + I A+D D ++ LH L D S F
Sbjct: 567 SSPFQATVLENVPLGYPV---------VHIQAVDAD--SGENARLHYRLVDTASTFLGGG 615
Query: 457 T-----------------GITRYLTLLQPVDREEQQTYTFSITAFD--GVQESEPVIVNI 497
+ + ++T+ +DREE + Y+F + A D S V+I
Sbjct: 616 SAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSI 675
Query: 498 QVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDF 556
V+D NDN P F + +Y++ + D G SV+ L A D D +N ITY++ G + F
Sbjct: 676 TVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRD--ANSVITYQLTGGNTRNRF 733
Query: 557 IIN--KTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 614
++ + GLIT+A ++ + Y L V A+D R+ V I V N P
Sbjct: 734 ALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGT-----RSHTAHVLINVTDANTHRPV 788
Query: 615 RFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTGILT 671
F Y++ +SE VG + L A D E ITY I++ PQ F + +G +
Sbjct: 789 -FQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ--FRIDPDSGTMY 845
Query: 672 LGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
LD E+ Y L I A D G P + T T+ I++ D NDNAP F + +
Sbjct: 846 TMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDA 905
Query: 731 EANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRITSNGSIYTAVKLNREVRDYYE 786
+ + QV ATD D+G NG++ Y+ + + ++G I T +L+RE Y
Sbjct: 906 PPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYN 965
Query: 787 LVVVATD-GAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKD 845
L +A D G+ P +++ + + +LDI+DN+P+F + VEEN P G+ + +I A D
Sbjct: 966 LWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRAND 1025
Query: 846 VDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYG 903
D G N + Y+I +++HFF L G+L + LD+E +V+A
Sbjct: 1026 PDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEV----RREYVLVVQA----- 1076
Query: 904 TMPPGI--ATVTVIVKDMNDYPPV 925
T P + ATV +++ D ND PPV
Sbjct: 1077 TSAPLVSRATVHILLVDQNDNPPV 1100
Score = 252 bits (644), Expect = 2e-66
Identities = 243/851 (28%), Positives = 388/851 (45%), Gaps = 89/851 (10%)
Query: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
+F + T +S ++R+ + L +KA + P A + + + D N+ SP F
Sbjct: 295 YFRIDSATGAVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFE 354
Query: 397 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
Y+ + E+ VG + L I A D+D + + L VF + +
Sbjct: 355 QSEYRERVRENLEVGYEV---------LTIRASDRDSPINANLRYRV-LGGAWDVFQLNE 404
Query: 457 -TGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPV----IVNIQVMDANDNTPTFPE 511
+G+ +L DREE Y + A D + P+ V I+V D NDN P F E
Sbjct: 405 SSGVVSTRAVL---DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSE 461
Query: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPG 570
+Y V V D+ +V+++ A D D+G N I Y IL G G F ++ +G++ +
Sbjct: 462 QNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP 521
Query: 571 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 630
++ + Y+L+++A D P NS V ++VL N+ + P F + + E +
Sbjct: 522 LDFEDVQKYSLSIKAQDGGRP-PLINSSGVVSVQVLDVND-NEPIFVSSPFQATVLENVP 579
Query: 631 VGAVLLNLQATDREG-----------DSITYAIENGD---------PQRVFNLSETTGIL 670
+G ++++QA D + D+ + + G P F + ++G +
Sbjct: 580 LGYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI 639
Query: 671 TLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNLSVV 728
T+ LDRE + Y + A D G P +S+ +V+I V DVNDN PVF P L+
Sbjct: 640 TVCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLN-E 698
Query: 729 EEEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITS---NGSIYTAVKLNREVRD 783
+ + V ++A D DA N + Y L GN N F ++S G I A+ L+ +
Sbjct: 699 DAAVGSSVLTLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQ 756
Query: 784 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEA 843
Y L V A+DG R T + I V D + + PVF +S YTV V E+ P GT+I + A
Sbjct: 757 QYVLAVTASDGT---RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
Query: 844 KDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDI 901
D D G N ++Y I+ P + F + P +G + + LDYE + + T + A D
Sbjct: 814 NDEDTGENARITYVIQDPVPQ--FRIDPDSGTMYTMMELDYE----NQVAYTLTIMAQDN 867
Query: 902 YGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPAS 961
T+ +++ D ND P F Y+G + DA T I V A D D P
Sbjct: 868 GIPQKSDTTTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSG--PNG 925
Query: 962 RVRYRV---DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MS 1017
R+ Y DD F +E SG + T+ L+ E ++ L +A D G P +S
Sbjct: 926 RLLYTFQGGDDGD-----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLS 980
Query: 1018 SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIV 1072
+S +++ +L + P F ++E V E G++V I A N I+Y IV
Sbjct: 981 ASVEIQVTILDINDNAPMFEKDELE-LFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIV 1039
Query: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
G+ F ++ + G + LD+E R YVL VQA S +V + A V+I
Sbjct: 1040 EGDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAPLV----------SRATVHI 1089
Query: 1133 EIQDENNHPPV 1143
+ D+N++PPV
Sbjct: 1090 LLVDQNDNPPV 1100
Score = 226 bits (575), Expect = 2e-58
Identities = 239/862 (27%), Positives = 379/862 (43%), Gaps = 109/862 (12%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTI-IYHEVRIVVRDRNDNSPTFKHESYYATV 156
ST VLDR+ + ++V+ + G + V I V D NDN P F ++Y V
Sbjct: 410 STRAVLDREEAAE-YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQV 468
Query: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-MLTGNIV 215
E + T + ATD D G N I Y I + N + L L+G +
Sbjct: 469 PEDVGLNTAVLRV-----QATDRDQGQNAAIHYSIL------SGNVAGQFYLHSLSGILD 517
Query: 216 LRKRLNYEDKTRYFVIIQAND--RAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPN 273
+ L++ED +Y + I+A D R +N ++ ++V VLD +D P+F+
Sbjct: 518 VINPLDFEDVQKYSLSIKAQDGGRPPLIN----SSGVVSVQVLDVNDNEPIFVSSPFQAT 573
Query: 274 TRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT--- 330
+ PL Y P++ IQA+D D S L+ LV T
Sbjct: 574 VLENVPLGY--------------PVV---HIQAVDAD------SGENARLHYRLVDTAST 610
Query: 331 -----------PEDYPRF-FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAF 378
P P F F +H + +++ ++R+ + + ++A P+ +
Sbjct: 611 FLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSSS 670
Query: 379 AGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKD 438
+ I +LD N+ P FT P+Y+ + E A VG+++ L + A D+D
Sbjct: 671 TSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV---------LTLQARDRDANSV-- 719
Query: 439 PELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQ 498
L + + F ++ +TL P+D +++Q Y ++TA DG + S V I
Sbjct: 720 ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDGTR-SHTAHVLIN 778
Query: 499 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 558
V DAN + P F Y V V D G S+ L+A D D G N ITY ++ F I
Sbjct: 779 VTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY-VIQDPVPQFRI 837
Query: 559 NKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQ 618
+ +G + ++ Y LT+ A DN P +++ T+ I +L N+ + P+F
Sbjct: 838 DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIP--QKSDTTTLEILILDANDNA-PQFLW 894
Query: 619 LMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP-QRVFNLSETTGILTLGK 674
Y I E +L + ATDR+ + Y + GD F + T+G++ +
Sbjct: 895 DFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQR 954
Query: 675 ALDRESTDRYILIITASD-GRPDGTSTAT-VNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
LDRE+ Y L A D G P S + + + + D+NDNAP+F+ L + EE
Sbjct: 955 RLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFE---KDELELFVEEN 1011
Query: 733 N---AFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYE 786
N + V +++A DPD G N Q+ Y + G+ + F++ NG + V+L+ EVR Y
Sbjct: 1012 NPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRREYV 1071
Query: 787 LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-----STYTVLVEENLPAGTTILQI 841
LVV AT P S T+ I ++D +DN PV + + Y + P G I I
Sbjct: 1072 LVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG-VIGCI 1127
Query: 842 EAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLD----YEAFPDQEASITFLVE 897
A D D+ +++Y L P TGEL L R LD EA E S++ +
Sbjct: 1128 PAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEAL--MEVSVSDGIH 1185
Query: 898 AFDIYGTMPPGIATVTVIVKDM 919
+ + T+ VT+I DM
Sbjct: 1186 SVTAFCTL-----RVTIITDDM 1202
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 266 bits (681), Expect = 1e-70
Identities = 321/1207 (26%), Positives = 520/1207 (43%), Gaps = 141/1207 (11%)
Query: 77 LKDNVDYWVL-----MDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYH 131
L D + Y++L V+ L + G DR+ + H + V+V+ N+ +
Sbjct: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQ-QDTHELAVEVRD-NRTPQRVAQG 2054
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
VR+ + D NDN P FKH YY + + T G +F ATD D G NG + Y
Sbjct: 2055 LVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLF-----QVSATDEDLGTNGAVTYEF 2109
Query: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTL 251
+D T F I L G+I L+K +Y+ +Y + + A D
Sbjct: 2110 ---AEDYT---YFRIDPYL-GDISLKKPFDYQALNKYHLKVIARDGG------------- 2149
Query: 252 TVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDR 311
T + ++ VLV PL +Q+ ++R PE N + TP + Q R
Sbjct: 2150 TPSLQSEEE--------VLVTVRNKSNPL-FQSPYYKVRVPE--NITLYTPILHT--QAR 2196
Query: 312 NIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+ P R ++Y+I+ E+ F +T L++ P++ + K ++A
Sbjct: 2197 S--PEGLR--LIYNIV---EEEPLMLFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDT- 2248
Query: 372 GHPLPAFAGLHIEIL--DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
L +F+ +E+L D N+ P F+ Y I E P T ++++A
Sbjct: 2249 --ALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPA---------QTPVIQLLAS 2297
Query: 430 DKDIEDTKDPELHLFL--NDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGV 487
D+D +D + +D + F + G T ++ +Q +D E QQ + + A D
Sbjct: 2298 DQDSGRNRDVSYQIVEDGSDVSKFFQI--NGSTGEMSTVQELDYEAQQHFHVKVRAMD-- 2353
Query: 488 QESEP-----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
+ +P +V + V D NDN P F + Y+ V G V+++ A+D D
Sbjct: 2354 -KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLVLKVQAIDPDSRDTS 2412
Query: 543 EITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
+ Y IL G Q F IN ++G+I++ + + +Y L V A+D + V
Sbjct: 2413 RLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGV-----FRATVPV 2467
Query: 602 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQ 658
YI N S P F Q +Y E++E VG +++L A D++ +I Y I N
Sbjct: 2468 YINTTNANKYS-PEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLAS 2526
Query: 659 RVFNLSETTGILTLGKALDRE-STDRYILI-ITASDGRPDGTSTATVNIVVTDVNDNAPV 716
F+++ I TL K LDRE ST+R I I + A DG + TV I++TD NDN P
Sbjct: 2527 EKFSINPNGQIATLQK-LDRENSTERVIAIKVMARDG-GGRVAFCTVKIILTDENDNPPQ 2584
Query: 717 F--DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTA 774
F Y S V +++ V QV A D D G N V YS+ + + + +
Sbjct: 2585 FKASEYTVSIQSNVSKDSP--VIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGV 2642
Query: 775 VK-------LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVL 827
VK L + D++ + A DG +S + + ++V+ + P F+ YT
Sbjct: 2643 VKVKDSLVGLENQTLDFF---IKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFS 2699
Query: 828 VEENLPAGTTI---LQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEA 884
E+LP G+ I + A+D + + V F+L P TG + + + +D+E+
Sbjct: 2700 APEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHES 2759
Query: 885 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 944
+ V A + T + +V + V D+ND PVF YK ++ + GT
Sbjct: 2760 TKLYQID----VMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTS 2815
Query: 945 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
+ V A D D +V YR+ +F ++ +SG + T L+ E +
Sbjct: 2816 VIQVTAIDKDTG--RDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHF 2873
Query: 1005 VVVAFDDGEPV-MSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA-- 1060
VVA+D G+ + +SS A V++ + + PRF EEYR V E + G +V +
Sbjct: 2874 HVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYR-GSVVENSEPGELVATLKTLD 2932
Query: 1061 ---AAINQSIVYSIVSGNEEDTFGINNITGVIYVNG--PLDYETRTSYVLRVQADSLEVV 1115
+ N+ + I G+ FGI+ + ++ LD E Y+LRV A +
Sbjct: 2933 ADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKF- 2991
Query: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
+ V I + D N++ P + Y G V ED +L+V ATD DT
Sbjct: 2992 ---------QASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDT 3042
Query: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1235
+ + Y L P G F ++ +TG + T R+ F ATD G G S +
Sbjct: 3043 NAQITYSLHGP----GAHEFKLDPHTGELTTLTALDRERKDVFNLVAKATD--GGGRSCQ 3096
Query: 1236 ADVLVSV 1242
AD+ + V
Sbjct: 3097 ADITLHV 3103
Score = 266 bits (681), Expect = 1e-70
Identities = 304/1145 (26%), Positives = 493/1145 (43%), Gaps = 119/1145 (10%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V I + N SP F+ Y A + E VGT + D A D D GP G I+Y I
Sbjct: 2467 VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVI-----DLLAIDKDSGPYGTIDYTII 2521
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
+ +++ F I G I ++L+ E+ T + I+ R R T+
Sbjct: 2522 ----NKLASEKFSINP--NGQIATLQKLDRENSTERVIAIKVMARDGG---GRVAFCTVK 2572
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
+ + D +D P F + Y +I + N +P IQ + D +
Sbjct: 2573 IILTDENDNPPQF------------KASEYTVSI-------QSNVSKDSPVIQVLAYDAD 2613
Query: 313 IQPPSDRPGILYSILVGTPEDYPR-FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN 371
+D + YS+ PED + ++P T + + + + +Q D IKA QD
Sbjct: 2614 EGQNAD---VTYSV---NPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKA-QDG 2666
Query: 372 GHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALD 430
G P + + ++++ + P F+ P Y E P G+ I ++ VA
Sbjct: 2667 GPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGI-------VKAVA-- 2717
Query: 431 KDIEDTKDPELHLFLNDYT------SVFTVT-QTGITRYLTLLQPVDREEQQTYTFSITA 483
+DP ++ + T VF++ TG+ + + +P+D E + Y + A
Sbjct: 2718 -----AQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIK---VRKPMDHESTKLYQIDVMA 2769
Query: 484 --FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
V VNIQV D NDN P F Y + +M G SVIQ+TA+D D G +
Sbjct: 2770 HCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRD 2829
Query: 542 GEITYEILVGAQGD----FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNS 597
G+++Y + + F I+ +G IT ++ +TY V A D+ + +S
Sbjct: 2830 GQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQL-SS 2888
Query: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD----REGDSITYAIE 653
V + + N+ +P RF Y + E G ++ L+ D + +T I
Sbjct: 2889 QALVQVSITDENDNAP-RFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYIT 2947
Query: 654 NGDPQRVFNLSETTGILTLG--KALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVN 711
GDP F +S+ + K LDRE T +Y+L +TASDG+ ++ TV I V DVN
Sbjct: 2948 EGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQ--ASVTVEIFVLDVN 3005
Query: 712 DNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSN-G 769
DN+P L + F+ +V ATD D N Q+ YSL G + F++ + G
Sbjct: 3006 DNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTG 3065
Query: 770 SIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 829
+ T L+RE +D + LV ATDG + +TL ++ D++DN+P F S V V
Sbjct: 3066 ELTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFFPSHCAVAVF 3123
Query: 830 ENLPAGTTILQIEAKDVDLGANVSYRIRSPE-VKHFFALHPFTGELSLLRSLDYEAFPDQ 888
+N T + + A+D D GAN P+ + F++ TG + L + L
Sbjct: 3124 DNTTVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRP---- 3179
Query: 889 EASITFLVEAFDIYGTMPPG-IATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 947
+A + V A D+ +P + TVTV V + DY PVF + V DA GT +
Sbjct: 3180 QAPLELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQ 3239
Query: 948 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 1007
+ PG A + YRV F ++ +G + +L+ E + + L +
Sbjct: 3240 LAT--LTRPG--AEKTGYRVVSGN---EQGRFRLDARTGILYVNASLDFETSPKYFLSIE 3292
Query: 1008 AFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAA----A 1062
+S TV + + E P+F Q+ Y V E A G ++ +SA
Sbjct: 3293 CSRKSSSSLSDVTTVMVNITDVNEHRPQFPQDPYSTR-VLENALVGDVILTVSATDEDGP 3351
Query: 1063 INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1122
+N I YS++ GN+ F I+ G + V LD E +SY L+++A + P
Sbjct: 3352 LNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRA-------TDSGQP 3404
Query: 1123 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDT-GNYSVMAY 1181
+ I++ D N++PP F + Y V E++ + + VL++ +D D+ N ++
Sbjct: 3405 PLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSF 3464
Query: 1182 RLIIPPIKEGKEGFVVE-TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLV 1240
R I +G G T G + TA + +++ Q+ A+D LS V V
Sbjct: 3465 R-----ITKGNNGSAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRV 3519
Query: 1241 SVVNQ 1245
V Q
Sbjct: 3520 HVTEQ 3524
Score = 266 bits (679), Expect = 2e-70
Identities = 281/1081 (25%), Positives = 486/1081 (44%), Gaps = 114/1081 (10%)
Query: 137 VRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPD 196
V+D NDN+P F Y T++E T VGTTI + D D NG++ Y +
Sbjct: 810 VKDWNDNAPRFPPGGYQLTISEDTEVGTTI-----AELTTKDADSEDNGRVRYTLL---- 860
Query: 197 DPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVL 256
PT + LTG +V+ L+ E + RY + ++A D+ + + T L + +
Sbjct: 861 SPTEKFSLH---PLTGELVVTGHLDRESEPRYILKVEARDQPSK-GHQLFSVTDLIITLE 916
Query: 257 DGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPP 316
D +D P C+ N L+ PE+L P V + A D D + P
Sbjct: 917 DVNDNSPQ---CITEHN--------------RLKVPEDLPPGTVLTFLDASDPD--LGPA 957
Query: 317 SDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP 376
+ +L GT F + T L L ++ + ++L + A D G PL
Sbjct: 958 GEVRYVLMDGAHGT-------FRVDLMTGALILERELDFERRAGYNLSLWA-SDGGRPLA 1009
Query: 377 AFAGLHIEIL----DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKD 432
H+E++ +EN P+F +QG + E++P G + IV +D
Sbjct: 1010 RRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV-----------IVVAAQD 1058
Query: 433 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD--GVQES 490
+ D EL FL T + + T + L P+DRE Y ++ A D V S
Sbjct: 1059 DDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLS 1118
Query: 491 EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
V I+V DANDN P + + + D G SV+QL A D D S G++T+ I
Sbjct: 1119 SVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITS 1178
Query: 551 G-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
G G F+I+ TGL++ A ++ + L V DN P+ + S V + +L N
Sbjct: 1179 GNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS--RVVVGILDVN 1236
Query: 610 NQSPPRFPQLMYSLEISEAMR--VGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLS 664
+ +PP F ++++ + E + + L A+D + +TY+IE+ D + F++
Sbjct: 1237 D-NPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD-EEAFSID 1294
Query: 665 ETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI--VVTDVNDNAPVFDPYL 721
TG+++ + + IL I A+D G+P +++ ++I + + P+
Sbjct: 1295 LVTGVVSSSSTF--TAGEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDET 1352
Query: 722 PRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKL 777
+ +V+E + N VG + G G +++ G+ + F I + GSI A L
Sbjct: 1353 YYSFTVMETDPVNHMVGVISV----EGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPL 1408
Query: 778 NREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 837
+ R Y L V TDG+ +T + +I+ + P F + Y V V ++ G
Sbjct: 1409 DTRRRSNYNLTVEVTDGS--RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVE 1466
Query: 838 ILQIEAKDVDLGANVSYRI---RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
+L+++A D D G ++ Y I + P F L P +G L + LD + P Q ++T
Sbjct: 1467 LLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQH-TLTV 1525
Query: 895 LVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
+V +I + VT+ V+D N +PP F++ Y+ V GT + V A DAD
Sbjct: 1526 MVRDQEI--PIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDAD 1583
Query: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
G+ A V Y + F + G + L++ L V A D G P
Sbjct: 1584 -RGVNA-EVHY---SLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSP 1638
Query: 1015 VMSSSATVKILVLHPGE--IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVYSIV 1072
ATV I+ ++P + P F++ EY + E G+ + ++SA + ++ + Y +
Sbjct: 1639 QWHDLATV-IIHVYPSDRSAPIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-VTYELR 1695
Query: 1073 SGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
GN++ F +N+ +G+I LD+E +SY L+++ ++ ++ V +
Sbjct: 1696 EGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDV---------MVVV 1746
Query: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLR-------VKATDKDTGNYSVMAYRLII 1185
+I DEN++ P+F K ++G +SE A +++ ++ + A+D D S++ Y+++
Sbjct: 1747 DIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILE 1806
Query: 1186 P 1186
P
Sbjct: 1807 P 1807
Score = 260 bits (665), Expect = 7e-69
Identities = 306/1229 (24%), Positives = 512/1229 (41%), Gaps = 185/1229 (15%)
Query: 113 SIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSG 172
S + +Q K + V + + D+ND P F SY T++E P+ + I
Sbjct: 114 SYTLIIQATEKTLELEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVT-- 171
Query: 173 DNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVII 232
ATD D G N + Y T ++ F I +G + + +LN + ++ + +
Sbjct: 172 ---ATDADLGQNAEFYYAFN------TRSEMFAIH-PTSGVVTVAGKLNVTWRGKHELQV 221
Query: 233 QANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTP 292
A DR + ++E G+ G + V V P LR P
Sbjct: 222 LAVDRMRKISE--------------GNGFGSLAALVVHVE--------------PALRKP 253
Query: 293 EELNPIIVTPP-------IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTA 345
+ ++VTPP + D N S ++ G P + + + R+
Sbjct: 254 PAIASVVVTPPDSNDGTTYATVLVDAN---SSGAEVESVEVVGGDPGKHFKAIKSYARSN 310
Query: 346 ELSLL--EPVN-RDFHQKFDLVIKAEQDNG-HPLPAFAGLHIEILDENNQSPYFTMPSYQ 401
E SL+ + +N ++ F+L ++A +G + G H+ S F Y+
Sbjct: 311 EFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLP--PSKLSSLKFEKAVYR 368
Query: 402 GYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE---LHLFLNDYTSVFTVTQTG 458
+ E +P G+ + +R+ +++ P + LN T + T T+
Sbjct: 369 VQLSEFSPPGSRVV-------MVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKL- 420
Query: 459 ITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYV 518
+D ++ Y I G + +V I ++D N++ P F SYD +
Sbjct: 421 ----------MDFHDRAHYQLHIRTSPGQAST---VVVIDIVDCNNHAPLFNRSSYDGTL 467
Query: 519 YTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEM-IVGR 577
++ PG SV+ +TA D D G NG +TY I F I+ G+I+ + ++ ++ R
Sbjct: 468 DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKR 527
Query: 578 TYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLN 637
Y V+A+D P R + +++++ L N + P F ++ + I + VG ++
Sbjct: 528 IYTFRVRASDWGSPFRREKEV-SIFLQ-LRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMT 585
Query: 638 LQATD-REGDSITYAIENGDPQRVFNLSETTGILTLGKA---LDRESTDRYILIITASDG 693
+ A D E ++ Y I +G+ F+L+ +G+++L + L Y L ITASDG
Sbjct: 586 MSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSLKITASDG 645
Query: 694 RPDGTSTATVNIVVT--------------------------------------------- 708
+ + S T+NI V
Sbjct: 646 K-NYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
Query: 709 -DVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
+N P F+ + P+++ V+E N + ++ ATDPDAG NG++ Y + GN F
Sbjct: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
Query: 765 IT-SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
I G + A L+ E ++Y L V D + S L + V D +DN+P F
Sbjct: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
Query: 824 YTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD 881
Y + + E+ GTTI ++ KD D N V Y + SP K F+LHP TGEL + LD
Sbjct: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLHPLTGELVVTGHLD 882
Query: 882 YEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDA 939
E+ E VEA D G + + + ++D+ND P + V D
Sbjct: 883 RES----EPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDL 938
Query: 940 VKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPT 999
GT +T + + +DP PA VRY + D F V+ +G +I L+ E
Sbjct: 939 PPGTVLT--FLDASDPDLGPAGEVRYVLMDGAH----GTFRVDLMTGALILERELDFERR 992
Query: 1000 TIFKLVVVAFDDGEPVMSSS-ATVKILV------LHPGEIPRFTQEEYRPPPVSELATKG 1052
+ L + A D G P+ + V+++V LHP F + V E + G
Sbjct: 993 AGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQ----GQVQENSPSG 1048
Query: 1053 TMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQ 1108
T V V++A + ++ + Y + +G F IN TG+I PLD E + Y L V
Sbjct: 1049 TQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVL 1108
Query: 1109 A-DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVK 1167
A D V L S+ +VYIE+ D N++PP + + + EDA + TSVL++
Sbjct: 1109 AVDRGSVPL--------SSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
Query: 1168 ATDKDTGNYSVMAYRLIIPPIKEGK--EGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1225
A D D+ + + + I G F++ TGL+ TA + +V
Sbjct: 1161 AWDPDSSSKGKLTFN-----ITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVL 1215
Query: 1226 DDYGKGLSGKADVLVSVVNQLDMQVIVSN 1254
D+ L + V+V +++ D I S+
Sbjct: 1216 DNGEPSLKSTSRVVVGILDVNDNPPIFSH 1244
Score = 257 bits (657), Expect = 6e-68
Identities = 306/1166 (26%), Positives = 493/1166 (42%), Gaps = 123/1166 (10%)
Query: 115 VVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDN 174
V V+ + +G+ V ++V D NDN PTF Y +++E P T +
Sbjct: 2240 VFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLL---- 2295
Query: 175 GATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQA 234
A+D D G N + Y I + D + F+I TG + + L+YE + + V ++A
Sbjct: 2296 -ASDQDSGRNRDVSYQIVEDGSDVSK--FFQIN-GSTGEMSTVQELDYEAQQHFHVKVRA 2351
Query: 235 NDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEE 294
D+ + T T + V+V D +D P F R Y+A + EL T
Sbjct: 2352 MDKG---DPPLTGETLVVVNVSDINDNPPEF------------RQPQYEANVSELATCGH 2396
Query: 295 LNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVN 354
L +QAID D D + Y IL G + R F ++ + +S+
Sbjct: 2397 L-----VLKVQAIDPDSR-----DTSRLEYLILSGNQD---RHFFINSSSGIISMFNLCK 2443
Query: 355 RDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI 414
+ ++L + A A ++I + N SP F Y+ + E+A VG +
Sbjct: 2444 KHLDSSYNLRVGASDG---VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKV 2500
Query: 415 SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREE- 473
D ++A+DKD + + + F++ G + LQ +DRE
Sbjct: 2501 ID---------LLAIDKDSGPYGTIDYTIINKLASEKFSINPNG---QIATLQKLDRENS 2548
Query: 474 -QQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT 532
++ + A DG V I + D NDN P F Y V + +++ VIQ+
Sbjct: 2549 TERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVL 2608
Query: 533 AVDADEGSNGEITYEILVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAP 590
A DADEG N ++TY + + IN TG++ + + + +T ++A D P
Sbjct: 2609 AYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGP 2668
Query: 591 PAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITY 650
P NS+ V ++V+ P S P+F + +Y+ E + G+ + ++A + D + Y
Sbjct: 2669 P--HWNSLVPVRLQVV-PKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIY 2724
Query: 651 AIENG-----DPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVN 704
++ G + VF+L TG++ + K +D EST Y + + A D S +VN
Sbjct: 2725 SLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVN 2784
Query: 705 IVVTDVNDNAPVF--DPY---LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--- 756
I V DVNDN PVF DPY L N+ V V QV A D D G +GQV Y L
Sbjct: 2785 IQVGDVNDNRPVFEADPYKAVLTENMPV-----GTSVIQVTAIDKDTGRDGQVSYRLSAD 2839
Query: 757 --GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATD-GAVHPRHSTLTLAIKVLDI 812
N + LF I S +G I T +L+ E Y VVA D G S + + + D
Sbjct: 2840 PGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDE 2899
Query: 813 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALHP 869
+DN+P F + Y V EN G + ++ D D+ V+ I + F +
Sbjct: 2900 NDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQ 2959
Query: 870 FTGE--LSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFS 927
E +S ++L D+E + +L+ G + TV + V D+ND P S
Sbjct: 2960 VGDEWRISSRKTL------DREHTAKYLLRVTASDGKFQASV-TVEIFVLDVNDNSPQCS 3012
Query: 928 KRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGR 987
+ +Y G V D G I V A D D +++ Y + A F+++ +G
Sbjct: 3013 QLLYTGKVHEDVFPGHFILKVSATDLDTD--TNAQITYSLHGP----GAHEFKLDPHTGE 3066
Query: 988 VITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSE 1047
+ T L+ E +F LV A D G + T+ + ++ PRF + V +
Sbjct: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVN-DNAPRFF-PSHCAVAVFD 3124
Query: 1048 LATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSY 1103
T T V V+ A N +VYS+ + E F I+ TGVI + PL +
Sbjct: 3125 NTTVKTPVAVVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGVIRLEKPLQVRPQAPL 3183
Query: 1104 VLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSV 1163
L V+A L + S V + + ++ PVF + V EDA T V
Sbjct: 3184 ELTVRASDLGTPI------PLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEV 3237
Query: 1164 LRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLI-KTAMLFHNMRRSYFKFQV 1222
L++ + + YR ++ ++G+ F ++ TG++ A L YF
Sbjct: 3238 LQLATLTRPGAEKT--GYR-VVSGNEQGR--FRLDARTGILYVNASLDFETSPKYF---- 3288
Query: 1223 IATDDYGKGLSGKADVLVSVVNQLDM 1248
++ + K S +DV +VN D+
Sbjct: 3289 LSIECSRKSSSSLSDVTTVMVNITDV 3314
Score = 253 bits (646), Expect = 1e-66
Identities = 302/1182 (25%), Positives = 497/1182 (42%), Gaps = 163/1182 (13%)
Query: 141 NDNSPTFK-HESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPT 199
N +P F+ H V E P+ T + ATD D G NG++ YVI D
Sbjct: 708 NHYTPQFEDHFPQSIDVLESVPINTPL-----ARLAATDPDAGFNGKLVYVIA----DGN 758
Query: 200 SNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGD 259
F+I L TG + + L+YE Y + + D ++++ LTV+V D +
Sbjct: 759 EEGCFDIELE-TGLLTVAAPLDYEATNFYILNVTVYDLG---TPQKSSWKLLTVNVKDWN 814
Query: 260 DLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDR 319
D P F P YQ I E E+ I + D + D
Sbjct: 815 DNAPRF------------PPGGYQLTISE---DTEVGTTIAELTTKDADSE-------DN 852
Query: 320 PGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA--EQDNGHPLPA 377
+ Y++L T + F +HP T EL + ++R+ ++ L ++A + GH L +
Sbjct: 853 GRVRYTLLSPTEK-----FSLHPLTGELVVTGHLDRESEPRYILKVEARDQPSKGHQLFS 907
Query: 378 FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTK 437
L I + D N+ SP + + E P G ++ D
Sbjct: 908 VTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLT-----------------FLDAS 950
Query: 438 DPEL-------HLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG---V 487
DP+L ++ ++ F V +T L L + +D E + Y S+ A DG +
Sbjct: 951 DPDLGPAGEVRYVLMDGAHGTFRVDL--MTGALILERELDFERRAGYNLSLWASDGGRPL 1008
Query: 488 QESEPVIVNIQVMDANDN--TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEIT 545
V + V+D N+N P F + V + G VI + A D D G +GE+
Sbjct: 1009 ARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQ 1068
Query: 546 YEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Y + G F IN+ TG+I ++ Y LTV A D + +S+ VYIE
Sbjct: 1069 YFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRG--SVPLSSVTEVYIE 1126
Query: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVF 661
V N+ +PP+ Q ++ I E VG +L L A D + S +T+ I +G+ F
Sbjct: 1127 VTDAND-NPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFF 1185
Query: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPV---- 716
+ TG+L+ + LDRE+ D +IL +T D G P ST+ V + + DVNDN P+
Sbjct: 1186 MIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHK 1245
Query: 717 -FDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNN-------LFRITSN 768
F+ LP LS V V ++ A+D D G+NG+V YS+ + + + + S+
Sbjct: 1246 LFNVRLPERLSPVSPGP---VYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSS 1302
Query: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPV---FTNSTYT 825
S +TA +Y L + ATD P +++ L I+ + S + F + Y+
Sbjct: 1303 SSTFTA-------GEYNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYS 1355
Query: 826 VLVEENLPAG--TTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
V E P ++ +E + N+S + + F + TG + + R LD
Sbjct: 1356 FTVMETDPVNHMVGVISVEGRPGLFWFNISGGDKDMD----FDIEKTTGSIVIARPLDTR 1411
Query: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGT 943
+ ++ VE D G+ ++ ++N + P F + Y+ V D V G
Sbjct: 1412 ----RRSNYNLTVEVTD--GSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGV 1465
Query: 944 PITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT--RVNLNEEPTTI 1001
+ V A D D + Y + Q P AS+F+++ SG ++T +++L P+
Sbjct: 1466 ELLRVQAIDQD----KGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQ- 1520
Query: 1002 FKLVVVAFDDGEPVMSSSATVKILV----LHPGEIPRFTQEEYRPPPVSELATKGTMVGV 1057
L V+ D P+ + V I V LHP PRFTQ Y +A ++ V
Sbjct: 1521 HTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHP---PRFTQLHYEASVPDTIAPGTELLQV 1577
Query: 1058 ISAAA---INQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1114
+ A +N + YS++ GN E F IN + G+I + LD + L V+A+
Sbjct: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAE---- 1633
Query: 1115 VLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG 1174
+ P + A V I + + P+F K Y + E + + +L V A
Sbjct: 1634 ---DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEV 1690
Query: 1175 NYSVMAYRLIIPPIKEG-KEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1232
Y ++EG K+G F + +Y+GLI T + + S ++ ++ G +
Sbjct: 1691 TYE----------LREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI-----RGSNM 1735
Query: 1233 SGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRY 1274
+G ++ VV+ +D N P L + ++E Y
Sbjct: 1736 AGAFTDVMVVVDIIDEN---DNAPMFLKSTFVGQISEAAPLY 1774
Score = 237 bits (604), Expect = 8e-62
Identities = 281/1154 (24%), Positives = 483/1154 (41%), Gaps = 149/1154 (12%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
EV I V D NDN P +Y ++ E PVGT++ A D D G++ + I
Sbjct: 1122 EVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----QLDAWDPDSSSKGKLTFNI 1176
Query: 192 QYNPDDPTSNDTFEIPLM--LTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
TS + ++ +TG + ++L+ E+K + + + D N +T+
Sbjct: 1177 -------TSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLD---NGEPSLKSTS 1226
Query: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
+ V +LD +D P+F + +R PE L+P+ P + +
Sbjct: 1227 RVVVGILDVNDNPPIF-----------------SHKLFNVRLPERLSPVSPGPVYRLVAS 1269
Query: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
D + G+ + + F + T +S + L IKA
Sbjct: 1270 DLD-------EGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGEYN--ILTIKATD 1320
Query: 370 DNGHPLPAFAGLHIEILDENNQSPY---FTMPSYQGYILESAPVGATISDSLNLTSP--- 423
PL A LHIE + S F Y ++E+ PV + P
Sbjct: 1321 SGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPGLF 1380
Query: 424 -LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSIT 482
I DKD++ F + +T T + + +P+D + Y ++
Sbjct: 1381 WFNISGGDKDMD-----------------FDIEKT--TGSIVIARPLDTRRRSNYNLTVE 1421
Query: 483 AFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNG 542
DG + + + + N + P F E Y+V V D PG ++++ A+D D+G +
Sbjct: 1422 VTDGSRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKS- 1480
Query: 543 EITYEIL----VGAQGDFIINKTTGLITIAPGVEMIVGRT-YALTVQAADNAPPAERRNS 597
+ Y I G+ F ++ ++G++ +++ G + + LTV D P +R
Sbjct: 1481 -LIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539
Query: 598 ICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIEN 654
T+++E N PPRF QL Y + + + G LL ++A D + + Y++
Sbjct: 1540 WVTIHVE---DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLK 1596
Query: 655 GDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDN 713
G+ + FN++ GI+TL + LD+ + + L + A D G P ATV I V + +
Sbjct: 1597 GNSEGFFNINALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
Query: 714 APVFDPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHYSL--GNFNNLFRITS 767
AP+F ++ VE + VG V A P +V Y L GN + +F + S
Sbjct: 1657 APIFS----KSEYFVEIPESIPVGSPILLVSAMSP-----SEVTYELREGNKDGVFSMNS 1707
Query: 768 -NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTV 826
+G I T KL+ E Y+L + ++ A + + + + ++D +DN+P+F ST+
Sbjct: 1708 YSGLISTQKKLDHEKISSYQLKIRGSNMA--GAFTDVMVVVDIIDENDNAPMFLKSTFVG 1765
Query: 827 LVEENLPAGTTILQ-------IEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLL 877
+ E P + I+ I A D D AN + Y+I PE FF + P G L+++
Sbjct: 1766 QISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIV 1825
Query: 878 RSLDYEAFPDQEASITFLVEAFDIYGTM--PPGIATVTVIVKDMNDYPPVFSKRIYKGMV 935
+DYE+ P S F V D + P A V + V+D+ND PP FS++IY+ +
Sbjct: 1826 SEMDYESMP----SFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAI 1881
Query: 936 APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLN 995
G + V A D D S V Y + +I V +G + LN
Sbjct: 1882 VGPIHPGMELLMVRASDED------SEVNYSIKTGNADEAVTIHPV---TGSISV---LN 1929
Query: 996 EEPTTIFKLVVVAFDDGEPVMSSSATVKI-LVLHPGEIPRFTQEEYRPPPVSELATKGTM 1054
+ + + + DG + +A VKI L + +F Q+ Y L + +
Sbjct: 1930 PAFLGLSRKLTIRASDG--LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL 1987
Query: 1055 VGVISAAA--INQSIVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADS 1111
V ++ A +N ++ Y +++G D F + GV+ G D E + ++ L V+
Sbjct: 1988 V-ILGAQGNHLNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVE--- 2041
Query: 1112 LEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDK 1171
+ + R P + V + I+D N++PP F+ Y + + + +V ATD+
Sbjct: 2042 ----VRDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDE 2097
Query: 1172 DTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKG 1231
D G + Y E F ++ Y G I F + + +VIA D
Sbjct: 2098 DLGTNGAVTYE-----FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPS 2152
Query: 1232 LSGKADVLVSVVNQ 1245
L + +VLV+V N+
Sbjct: 2153 LQSEEEVLVTVRNK 2166
Score = 232 bits (592), Expect = 2e-60
Identities = 250/923 (27%), Positives = 414/923 (44%), Gaps = 79/923 (8%)
Query: 354 NRDFHQKFDLVIKAEQDNGHPLPAFAGL-HIEILDENNQSPYFTMPSYQGYILESAPVGA 412
+R+ +L ++ +DN P GL + I D N+ P F Y I + G
Sbjct: 2029 DREQQDTHELAVEV-RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGD 2087
Query: 413 TISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 472
+ ++ A D+D+ T + F DYT G ++L +P D +
Sbjct: 2088 VL---------FQVSATDEDL-GTNGAVTYEFAEDYTYFRIDPYLGD---ISLKKPFDYQ 2134
Query: 473 EQQTYTFSITAFDG----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 528
Y + A DG +Q E V+V ++ N + P F Y V V ++ +
Sbjct: 2135 ALNKYHLKVIARDGGTPSLQSEEEVLVTVR----NKSNPLFQSPYYKVRVPENITLYTPI 2190
Query: 529 IQLTAVDADEGSN---GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQA 585
+ T + EG + E L+ DF TG++T+ ++ + TV+A
Sbjct: 2191 LH-TQARSPEGLRLIYNIVEEEPLMLFTTDF----KTGVLTVTGPLDYESKTKHVFTVRA 2245
Query: 586 ADNAPPAERRNSICTVYIEVLPPN-NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE 644
D A S +EVL + N +PP F QL+Y+ ISE + ++ L A+D++
Sbjct: 2246 TDTA-----LGSFSEATVEVLVEDVNDNPPTFSQLVYTTSISEGLPAQTPVIQLLASDQD 2300
Query: 645 GD---SITYAI--ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGT 698
++Y I + D + F ++ +TG ++ + LD E+ + + + A D G P T
Sbjct: 2301 SGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLT 2360
Query: 699 STATVNIVVTDVNDNAPVF-DPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL- 756
V + V+D+NDN P F P N+S + V +V+A DPD+ ++ Y +
Sbjct: 2361 GETLVVVNVSDINDNPPEFRQPQYEANVSELAT-CGHLVLKVQAIDPDSRDTSRLEYLIL 2419
Query: 757 -GNFNNLFRITSNGSIYTAVKLNREVRDY-YELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
GN + F I S+ I + L ++ D Y L V A+DG +T+ + I + +
Sbjct: 2420 SGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFR---ATVPVYINTTNANK 2476
Query: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTG 872
SP F Y + EN GT ++ + A D D G + Y I + F+++P G
Sbjct: 2477 YSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINP-NG 2535
Query: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
+++ L+ LD E E I V A D G + TV +I+ D ND PP F Y
Sbjct: 2536 QIATLQKLDREN--STERVIAIKVMARDGGGRV--AFCTVKIILTDENDNPPQFKASEYT 2591
Query: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
+ + K +P+ V A DAD G A V Y V+ + E+ +G V +
Sbjct: 2592 VSIQSNVSKDSPVIQVLAYDADE-GQNAD-VTYSVNPEDLV--KDVIEINPVTGVVKVKD 2647
Query: 993 NLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATK 1051
+L + A D G P +S V++ V+ +P+F++ Y +L +
Sbjct: 2648 SLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLP-E 2706
Query: 1052 GTMVGVISAAAINQSIVYSIVSG-----NEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1106
G+ +G++ A A ++YS+V G N++ F ++ TGVI V P+D+E+ Y +
Sbjct: 2707 GSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQID 2766
Query: 1107 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
V A L+ N V S V I++ D N++ PVF+ Y ++E+ + TSV++V
Sbjct: 2767 VMAHCLQ----NTDVVS---LVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQV 2819
Query: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
A DKDTG ++YRL P E F +++ +G I T + F V+A
Sbjct: 2820 TAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAY- 2878
Query: 1227 DYGK--GLSGKADVLVSVVNQLD 1247
D+G+ LS +A V VS+ ++ D
Sbjct: 2879 DHGQTIQLSSQALVQVSITDEND 2901
Score = 223 bits (567), Expect = 2e-57
Identities = 301/1189 (25%), Positives = 502/1189 (42%), Gaps = 138/1189 (11%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIV-VRDRNDNSPTFKHESYYATV 156
ST + LD + + H V+V+ ++K + + +V V D NDN P F+ Y A V
Sbjct: 2332 STVQELDYEAQQHFH---VKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANV 2388
Query: 157 NELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIP-LMLTGNIV 215
+EL G V++ DP S DT + L+L+GN
Sbjct: 2389 SELATCG------------------------HLVLKVQAIDPDSRDTSRLEYLILSGN-- 2422
Query: 216 LRKRLNYEDKTRYFVIIQANDRAQNLNE-RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNT 274
+ R+F I ++ N ++ ++ + V D + +P +
Sbjct: 2423 ---------QDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASDGVFRATVPVYINTTN 2473
Query: 275 RDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDY 334
+ +Q + E E N ++ T I + D++ P I Y+I+ +
Sbjct: 2474 ANKYSPEFQQHLYEAELAE--NAMVGTKVIDLLAIDKDSGPYGT---IDYTIINKLASEK 2528
Query: 335 PRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPY 394
F ++P +++ L+ ++R+ + + IK +G AF + I + DEN+ P
Sbjct: 2529 ---FSINPN-GQIATLQKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQ 2584
Query: 395 FTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
F Y +I +++ SP+ I L D ++ ++ ++ +N V V
Sbjct: 2585 FKASEYT----------VSIQSNVSKDSPV-IQVLAYDADEGQNADVTYSVNPEDLVKDV 2633
Query: 455 TQTG-ITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPE 511
+ +T + + + E QT F I A DG + V V +QV+ + P F E
Sbjct: 2634 IEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVSLPKFSE 2693
Query: 512 ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA------QGDFIINKTTGLI 565
Y D+ G + + AV A + + Y ++ G G F ++ TG+I
Sbjct: 2694 PLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTTPESNKDGVFSLDPDTGVI 2749
Query: 566 TIAPGVEMIVGRTYALTVQA--ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
+ ++ + Y + V A N S+ +V I+V N+ P F Y
Sbjct: 2750 KVRKPMDHESTKLYQIDVMAHCLQNTDVV----SLVSVNIQVGDVNDNRPV-FEADPYKA 2804
Query: 624 EISEAMRVGAVLLNLQATDRE---GDSITYAIENGDP----QRVFNLSETTGILTLGKAL 676
++E M VG ++ + A D++ ++Y + + DP +F + +G +T + L
Sbjct: 2805 VLTENMPVGTSVIQVTAIDKDTGRDGQVSYRL-SADPGSNVHELFAIDSESGWITTLQEL 2863
Query: 677 DRESTDRYILIITASDGRP--DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 734
D E+ Y + A D +S A V + +TD NDNAP F R V E
Sbjct: 2864 DCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGE 2923
Query: 735 FVGQVKATDPDAGI-NGQV--HYSLGNFNNLFRITSNGS---IYTAVKLNREVRDYYELV 788
V +K D D N QV + + G+ F I+ G I + L+RE Y L
Sbjct: 2924 LVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLR 2983
Query: 789 VVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL 848
V A+DG +++T+ I VLD++DNSP + YT V E++ G IL++ A D+D
Sbjct: 2984 VTASDGKFQ---ASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDT 3040
Query: 849 GAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP 906
N ++Y + P H F L P TGEL+ L +LD E ++ + +A D G
Sbjct: 3041 DTNAQITYSLHGPGA-HEFKLDPHTGELTTLTALDRE----RKDVFNLVAKATDGGGRSC 3095
Query: 907 PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYR 966
A +T+ V+D+ND P F V + TP+ V+A D D ++V Y
Sbjct: 3096 Q--ADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQGA--NAQVVYS 3151
Query: 967 VDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV-MSSSATVKIL 1025
+ D + F ++ +G + L P +L V A D G P+ +S+ TV +
Sbjct: 3152 LPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLGTVTVS 3207
Query: 1026 VLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAIN----QSIVYSIVSGNEEDTF 1080
V+ + +P F E+ V E A GT V + A + + Y +VSGNE+ F
Sbjct: 3208 VVGLEDYLPVFLNTEHSVQ-VPEDAPPGTEV--LQLATLTRPGAEKTGYRVVSGNEQGRF 3264
Query: 1081 GINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
++ TG++YVN LD+ET Y L ++ + S S+ V + I D N H
Sbjct: 3265 RLDARTGILYVNASLDFETSPKYFLSIEC-------SRKSSSSLSDVTTVMVNITDVNEH 3317
Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKE--GFVVE 1198
P F + Y V E+A + +L V ATD+D S + Y LI G + F +
Sbjct: 3318 RPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLI-----GGNQLGHFTIH 3372
Query: 1199 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
G ++ A + S + ++ ATD L D+ + V + D
Sbjct: 3373 PKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVND 3421
Score = 220 bits (560), Expect = 1e-56
Identities = 268/1071 (25%), Positives = 447/1071 (41%), Gaps = 103/1071 (9%)
Query: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
I + D NDNSP E V E P GT + A+D D GP G++ YV+
Sbjct: 913 ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTF-----LDASDPDLGPAGEVRYVLMDG 967
Query: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
++ TF + LM TG ++L + L++E + Y + + A+D + L R T + V
Sbjct: 968 -----AHGTFRVDLM-TGALILERELDFERRAGYNLSLWASDGGRPLARR--TLCHVEVI 1019
Query: 255 VLD-GDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNI 313
VLD ++L P + +Q + E +P I+V A D D +
Sbjct: 1020 VLDVNENLHPPHFASFV-----------HQGQVQE-NSPSGTQVIVVA----AQDDDSGL 1063
Query: 314 QPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGH 373
+ Y + GT F ++ T + L P++R+F + L + A
Sbjct: 1064 DGE-----LQYFLRAGTGL---AAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSV 1115
Query: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDI 433
PL + ++IE+ D N+ P + + I E APVG TS L++ A D D
Sbjct: 1116 PLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVG---------TSVLQLDAWDPDS 1166
Query: 434 EDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES--E 491
++ +Y F + +T L+ Q +DRE + + +T D + S
Sbjct: 1167 SSKGKLTFNITSGNYMGFFMIHP--VTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKS 1224
Query: 492 PVIVNIQVMDANDNTPTFPEISYDVYVYTDMRP--GDSVIQLTAVDADEGSNGEITYEIL 549
V + ++D NDN P F ++V + + P V +L A D DEG NG +TY I
Sbjct: 1225 TSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIE 1284
Query: 550 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLP-P 608
+ F I+ TG+++ + G LT++A D+ P ++ ++IE +P P
Sbjct: 1285 DSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTIKATDSGQPP--LSASVRLHIEWIPWP 1340
Query: 609 NNQS-PPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETT 667
S P F + YS + E V ++ + R G + I GD F++ +TT
Sbjct: 1341 RPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGRPG-LFWFNISGGDKDMDFDIEKTT 1399
Query: 668 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNI-VVTDVNDNAPVFDPYLPRNLS 726
G + + + LD Y L + +DG T V+I ++ ++N + P F
Sbjct: 1400 GSIVIARPLDTRRRSNYNLTVEVTDG--SRTIATQVHIFMIANINHHRPQFLETRYEVRV 1457
Query: 727 VVEEEANAFVGQVKATDPDAG--INGQVHYSLG-NFNNLFRI-TSNGSIYTAVKLN-REV 781
+ + +V+A D D G + +H S +LF++ S+G + T KL+
Sbjct: 1458 PQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSG 1517
Query: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
+ L V+ D + + + + + I V D + + P FT Y V + + GT +LQ+
Sbjct: 1518 PSQHTLTVMVRDQEIPIKRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIAPGTELLQV 1577
Query: 842 EAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAF 899
A D D G N V Y + + FF ++ G ++L + LD A T V+A
Sbjct: 1578 RAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQKLDQA----NHAPHTLTVKAE 1633
Query: 900 DIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLP 959
D +ATV + V + P+FSK Y + G+PI V A +
Sbjct: 1634 DQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSA-------MS 1686
Query: 960 ASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSS 1019
S V Y + + +F + SG + T+ L+ E + ++L + +
Sbjct: 1687 PSEVTYELREGN---KDGVFSMNSYSGLISTQKKLDHEKISSYQLKIRGSNMAGAFTDVM 1743
Query: 1020 ATVKILVLHPGEIPRFTQEEY------RPPPVSELATKGTMVGVISAA----AINQSIVY 1069
V I + P F + + P S + K VI A+ N +VY
Sbjct: 1744 VVVDI-IDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
Query: 1070 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA-DSLEVVLANLRVPSKSNTA 1128
I+ F I+ G + + +DYE+ S+ V D VL R A
Sbjct: 1803 KILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFAPR------PA 1856
Query: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTG-NYSV 1178
+V I ++D N+ PP F ++ Y + +L V+A+D+D+ NYS+
Sbjct: 1857 QVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVNYSI 1907
Score = 218 bits (554), Expect = 5e-56
Identities = 237/869 (27%), Positives = 361/869 (41%), Gaps = 94/869 (10%)
Query: 111 IHSIVVQVQCI-NKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTG 169
++ I V C+ N V +++ V I V D NDN P F+ + Y A + E PVGT++
Sbjct: 2762 LYQIDVMAHCLQNTDVVSLV--SVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVI-- 2817
Query: 170 FSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF 229
A D D G +GQ+ Y + +P ++ F I +G I + L+ E Y
Sbjct: 2818 ---QVTAIDKDTGRDGQVSYRLSADPGSNV-HELFAIDSE-SGWITTLQELDCETCQTYH 2872
Query: 230 VIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL 289
+ A D Q + + ++ + V + D +D P F Y+ ++ E
Sbjct: 2873 FHVVAYDHGQTI--QLSSQALVQVSITDENDNAPRFAS------------EEYRGSVVEN 2918
Query: 290 RTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL 349
P EL + T +Q+R + L + D R +S
Sbjct: 2919 SEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWR----------ISS 2968
Query: 350 LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAP 409
+ ++R+ K+ L + A A + I +LD N+ SP + Y G + E
Sbjct: 2969 RKTLDREHTAKYLLRVTASDGK---FQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVF 3025
Query: 410 VGATISDSLNLTSPLRIVALDKDIEDTKD-------PELHLFLNDYTSVFTVTQTGITRY 462
G I L++ A D D + P H F D TG
Sbjct: 3026 PGHFI---------LKVSATDLDTDTNAQITYSLHGPGAHEFKLD-------PHTG---E 3066
Query: 463 LTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDM 522
LT L +DRE + + A DG S + + V D NDN P F V V+ +
Sbjct: 3067 LTTLTALDRERKDVFNLVAKATDGGGRSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNT 3126
Query: 523 RPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALT 582
V + A D D+G+N ++ Y + A+G F I+ TTG+I + +++ LT
Sbjct: 3127 TVKTPVAVVFARDPDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELT 3186
Query: 583 VQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATD 642
V+A+D P +++ TV + V+ + P F +S+++ E G +L L
Sbjct: 3187 VRASDLGTPIP-LSTLGTVTVSVVGLEDYLPV-FLNTEHSVQVPEDAPPGTEVLQLATLT 3244
Query: 643 REGDSIT-YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTS-T 700
R G T Y + +G+ Q F L TGIL + +LD E++ +Y L I S S
Sbjct: 3245 RPGAEKTGYRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDV 3304
Query: 701 ATVNIVVTDVNDNAPVF--DPYLPRNLSVVEEEANAFVGQ----VKATDPDAGINGQVHY 754
TV + +TDVN++ P F DPY R L NA VG V ATD D +N + Y
Sbjct: 3305 TTVMVNITDVNEHRPQFPQDPYSTRVLE------NALVGDVILTVSATDEDGPLNSDITY 3358
Query: 755 SLGNFNNLFRIT---SNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLD 811
SL N L T G + A L+RE Y L + ATD P H +AI+V D
Sbjct: 3359 SLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVAD 3418
Query: 812 IDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDL---GANVSYRIRSPEVKHFFALH 868
++DN P F Y+ V+EN P G+ +LQ+ D D G S+RI F +
Sbjct: 3419 VNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVT 3478
Query: 869 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 926
P G L L A + ++A D +PP + +V V V + + Y P
Sbjct: 3479 P-DGWLVTAEGLSRRA----QEWYQLQIQASD--SGIPPLSSLTSVRVHVTEQSHYAPSA 3531
Query: 927 SKRIYKGMVAPDAVKGTPITTVYAEDADP 955
V D +G + ++A D DP
Sbjct: 3532 LPLEIFITVGEDEFQGGMVGKIHATDRDP 3560
Score = 213 bits (542), Expect = 1e-54
Identities = 271/1123 (24%), Positives = 460/1123 (40%), Gaps = 120/1123 (10%)
Query: 130 YHEVRIVVR--DRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGD--NGATDIDDGPNG 185
+ +V +VV D NDN+P F ++ ++E P+ + I + A+D D N
Sbjct: 1739 FTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANS 1798
Query: 186 QIEYVIQYNPDDPTSNDTFEI-PLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNER 244
+ Y I +P + F+I P M G + + ++YE + + +D+ +
Sbjct: 1799 LLVYKIL----EPEALKFFKIDPSM--GTLTIVSEMDYESMPSFQFCVYVHDQGSPVLFA 1852
Query: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPI 304
+ + V D +D P F I E+ ++P + +
Sbjct: 1853 PRPAQVI-IHVRDVNDSPPRF-----------------SEQIYEVAIVGPIHPGMELLMV 1894
Query: 305 QAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLV 364
+A D+D + YSI G ++ +HP T +S+L P +K L
Sbjct: 1895 RASDEDSEVN---------YSIKTGNADE---AVTIHPVTGSISVLNPAFLGLSRK--LT 1940
Query: 365 IKAEQDNGHPLPAFAGLHI-EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP 423
I+A D + A + + ++LD++ Q F Y + E NL
Sbjct: 1941 IRA-SDGLYQDTALVKISLTQVLDKSLQ---FDQDVYWAAVKE------------NLQDR 1984
Query: 424 LRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA 483
+V L D + LN V G+ + T DRE+Q T+ ++
Sbjct: 1985 KALVILGAQGNHLNDTLSYFLLNGTDMFHMVQSAGVLQ--TRGVAFDREQQDTHELAVEV 2042
Query: 484 FDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
D Q +V + + D NDN P F + Y + PGD + Q++A D D G+N
Sbjct: 2043 RDNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTN 2102
Query: 542 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTV 601
G +TYE F I+ G I++ + Y L V A D P+ + V
Sbjct: 2103 GAVTYE-FAEDYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLV 2161
Query: 602 YIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDSITYAIENGDPQRVF 661
+ N+S P F Y + + E + + +L+ QA EG + Y I +P +F
Sbjct: 2162 TV-----RNKSNPLFQSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLF 2216
Query: 662 NLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
TG+LT+ LD ES +++ + A+D S ATV ++V DVNDN P F +
Sbjct: 2217 TTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVNDNPPTFSQLV 2276
Query: 722 PRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL----GNFNNLFRIT-SNGSIYTAVK 776
A V Q+ A+D D+G N V Y + + + F+I S G + T +
Sbjct: 2277 YTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQE 2336
Query: 777 LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT 836
L+ E + ++ + V A D P + + V DI+DN P F Y V E G
Sbjct: 2337 LDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGH 2396
Query: 837 TILQIEAKDVDL--GANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITF 894
+L+++A D D + + Y I S F ++ +G +S+ ++S
Sbjct: 2397 LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHL----DSSYNL 2452
Query: 895 LVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
V A D T+P I T + N Y P F + +Y+ +A +A+ GT + + A D
Sbjct: 2453 RVGASDGVFRATVPVYINTT-----NANKYSPEFQQHLYEAELAENAMVGTKVIDLLAID 2507
Query: 953 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTT--IFKLVVVAFD 1010
D P + Y + + SI +G++ T L+ E +T + + V+A D
Sbjct: 2508 KDSG--PYGTIDYTIINKLASEKFSI----NPNGQIATLQKLDRENSTERVIAIKVMARD 2561
Query: 1011 DGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAA---INQS 1066
G V + TVKI++ + P+F EY S ++ ++ V++ A N
Sbjct: 2562 GGGRV--AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNAD 2619
Query: 1067 IVYSIVSGN-EEDTFGINNITGVIYVNGPL-DYETRT-SYVLRVQADSLEVVLANLRVPS 1123
+ YS+ + +D IN +TGV+ V L E +T + ++ Q P
Sbjct: 2620 VTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDGG---------PPH 2670
Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKA-TDKDTGNYSVMAYR 1182
++ V +++ + P F + Y ED + + VKA +D YS++ R
Sbjct: 2671 WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLV--R 2728
Query: 1183 LIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIA 1224
P + K+G F ++ TG+IK + ++ V+A
Sbjct: 2729 GTTP--ESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMA 2769
Score = 200 bits (509), Expect = 8e-51
Identities = 278/1131 (24%), Positives = 472/1131 (41%), Gaps = 137/1131 (12%)
Query: 125 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIF--TGFSGDNGATDIDDG 182
+ T+I H V + ++P F Y+ + E PVG+ I + S ++ +G
Sbjct: 1643 LATVIIH-----VYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSPSEVTYELREG 1697
Query: 183 PNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLN 242
N D S +++ +G I +K+L++E + Y + I+ ++ A
Sbjct: 1698 -----------NKDGVFSMNSY------SGLISTQKKLDHEKISSYQLKIRGSNMAGAF- 1739
Query: 243 ERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTP 302
T + VD++D +D PMFL V + PL + + NP +
Sbjct: 1740 ----TDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLY------SMIMDKNNNPFV--- 1786
Query: 303 PIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD 362
I A D D+ ++Y IL PE +FF + P L+++ ++ + F
Sbjct: 1787 -IHASDSDKEANSL-----LVYKIL--EPEAL-KFFKIDPSMGTLTIVSEMDYESMPSFQ 1837
Query: 363 LVIKAEQDNGHPL---PAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
+ D G P+ P A + I + D N+ P F+ Y+ I+ G +
Sbjct: 1838 FCVYV-HDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMEL----- 1891
Query: 420 LTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTF 479
L + A D +D E++ + + VT +T +++L P + T
Sbjct: 1892 ----LMVRASD------EDSEVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRKLT- 1940
Query: 480 SITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 539
I A DG+ + + +V I + D + F + Y V +++ +++ L A
Sbjct: 1941 -IRASDGLYQ-DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--QGNH 1996
Query: 540 SNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSIC 599
N ++Y +L G ++ L T + T+ L V+ DN P +
Sbjct: 1997 LNDTLSYFLLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLV 2056
Query: 600 TVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAIENGDPQ 658
V IE + N +PP+F L Y I + G VL + ATD + G + E +
Sbjct: 2057 RVSIEDV---NDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDY 2113
Query: 659 RVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTST--ATVNIVVTDVNDNAPV 716
F + G ++L K D ++ ++Y L + A DG GT + + ++VT N + P+
Sbjct: 2114 TYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDG---GTPSLQSEEEVLVTVRNKSNPL 2170
Query: 717 F-DPY----LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN--- 768
F PY +P N+++ + +A P+ G+ ++ Y++ L T++
Sbjct: 2171 FQSPYYKVRVPENITLYTP-----ILHTQARSPE-GL--RLIYNIVEEEPLMLFTTDFKT 2222
Query: 769 GSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
G + L+ E + + V ATD A+ S T+ + V D++DN P F+ YT +
Sbjct: 2223 GVLTVTGPLDYESKTKHVFTVRATDTAL-GSFSEATVEVLVEDVNDNPPTFSQLVYTTSI 2281
Query: 829 EENLPAGTTILQIEAKDVDLGAN--VSYRI--RSPEVKHFFALHPFTGELSLLRSLDYEA 884
E LPA T ++Q+ A D D G N VSY+I +V FF ++ TGE+S ++ LDYEA
Sbjct: 2282 SEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEA 2341
Query: 885 FPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTP 944
+ V A D G V V V D+ND PP F + Y+ V+ A G
Sbjct: 2342 ----QQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHL 2397
Query: 945 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
+ V A DP SR+ Y + F + SG +I+ NL ++
Sbjct: 2398 VLKVQA--IDPDSRDTSRLEYLILSGN---QDRHFFINSSSG-IISMFNLCKKHLDSSYN 2451
Query: 1005 VVVAFDDGEPVMSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVG--VISAA 1061
+ V DG V ++ V I + + P F Q Y +ELA + MVG VI
Sbjct: 2452 LRVGASDG--VFRATVPVYINTTNANKYSPEFQQHLYE----AELA-ENAMVGTKVIDLL 2504
Query: 1062 AINQ------SIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1115
AI++ +I Y+I++ + F IN G I LD E T V+ ++ + +
Sbjct: 2505 AIDKDSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKLDRENSTERVIAIKVMARD-- 2561
Query: 1116 LANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN 1175
+ V I + DEN++PP F+ Y + + + V++V A D D G
Sbjct: 2562 -----GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQ 2616
Query: 1176 YSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
+ + Y + P K+ + TG++K + F + A D
Sbjct: 2617 NADVTYS--VNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD 2665
Score = 196 bits (499), Expect = 1e-49
Identities = 251/1002 (25%), Positives = 424/1002 (42%), Gaps = 127/1002 (12%)
Query: 133 VRIVVRDRNDN--SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
V ++V D N+N P F + V E +P GT + A D D G +G+++Y
Sbjct: 1016 VEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIV-----VAAQDDDSGLDGELQYF 1070
Query: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
++ T F I TG I L+ E + Y++ + A DR + ++ T
Sbjct: 1071 LRAG----TGLAAFSIN-QDTGMIQTLAPLDREFASYYWLTVLAVDRG---SVPLSSVTE 1122
Query: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
+ ++V D +D P V P+ ++ P+ + A D D
Sbjct: 1123 VYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVL-----------------QLDAWDPD 1165
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
S + + ++I G +Y FF +HP T LS + ++R+ + L + D
Sbjct: 1166 -----SSSKGKLTFNITSG---NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTV-LD 1216
Query: 371 NGHP-LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSP---LRI 426
NG P L + + + + ILD N+ P F+ + + + L+ SP R+
Sbjct: 1217 NGEPSLKSTSRVVVGILDVNDNPPIFSHKLF----------NVRLPERLSPVSPGPVYRL 1266
Query: 427 VALDKD----------IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQT 476
VA D D IED+ + + L T V + + T +L
Sbjct: 1267 VASDLDEGLNGRVTYSIEDSDEEAFSIDL--VTGVVSSSSTFTAGEYNIL---------- 1314
Query: 477 YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYD--VYVYTDMRPGDSVIQLTAV 534
+I A D Q V + + P+ +++D Y +T M D V + V
Sbjct: 1315 ---TIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMET-DPVNHMVGV 1370
Query: 535 DADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAE 593
+ EG G + I G + DF I KTTG I IA ++ Y LTV+ D +
Sbjct: 1371 ISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGS---- 1426
Query: 594 RRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE-GDSITYAI 652
R V+I ++ N P+F + Y + + + G LL +QA D++ G S+ Y I
Sbjct: 1427 -RTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTI 1485
Query: 653 ENG-DP--QRVFNLSETTGIL-TLGKALDRESTDRYILIITASDGR-PDGTSTATVNIVV 707
DP +F L ++G+L T+GK ++ L + D P + V I V
Sbjct: 1486 HGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHV 1545
Query: 708 TDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFR 764
D N + P F L SV + A + QV+A D D G+N +VHYSL GN F
Sbjct: 1546 EDGNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604
Query: 765 ITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNST 823
I + G I A KL++ + L V A D H T+ I V D ++P+F+ S
Sbjct: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSE 1664
Query: 824 YTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYE 883
Y V + E++P G+ IL + A + V+Y +R F+++ ++G +S + LD+E
Sbjct: 1665 YFVEIPESIPVGSPILLVSAMS---PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721
Query: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--- 940
+S + ++ G + V +I D ND P+F K + G ++ A
Sbjct: 1722 KI----SSYQLKIRGSNMAGAFTDVMVVVDII--DENDNAPMFLKSTFVGQISEAAPLYS 1775
Query: 941 ----KGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
K ++A D+D S + Y++ + P F+++ G + ++
Sbjct: 1776 MIMDKNNNPFVIHASDSDKEA--NSLLVYKILE---PEALKFFKIDPSMGTLTIVSEMDY 1830
Query: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEI----PRFTQEEYRPPPVSELATKG 1052
E F+ V D G PV+ + ++ ++H ++ PRF+++ Y V + G
Sbjct: 1831 ESMPSFQFCVYVHDQGSPVLFAPRPAQV-IIHVRDVNDSPPRFSEQIYEVAIVGPI-HPG 1888
Query: 1053 TMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGP 1094
+ ++ A+ + + YSI +GN ++ I+ +TG I V P
Sbjct: 1889 MELLMVRASDEDSEVNYSIKTGNADEAVTIHPVTGSISVLNP 1930
Score = 179 bits (454), Expect = 2e-44
Identities = 189/752 (25%), Positives = 320/752 (42%), Gaps = 85/752 (11%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V++ + D NDN+P F E Y +V E + G + T + D DI + Y+ +
Sbjct: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLD---ADISEQNRQVTCYITE 2948
Query: 193 YNPDDPTSNDTFEIPLMLTGN---IVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
+P + + G+ I RK L+ E +Y + + A+D + +
Sbjct: 2949 GDP-------LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG------KFQASV 2995
Query: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
T+ + VLD +D N+ C L Y + E P I+ +D
Sbjct: 2996 TVEIFVLDVND------------NSPQCSQLLYTGKVHEDVFPGHF---ILKVSATDLDT 3040
Query: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQ 369
D N Q I YS+ + F + P T EL+ L ++R+ F+LV KA
Sbjct: 3041 DTNAQ-------ITYSLHGPGAHE----FKLDPHTGELTTLTALDRERKDVFNLVAKATD 3089
Query: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
G A LH+E D N+ +P F PS+ + D+ + +P+ +V
Sbjct: 3090 GGGRSCQADITLHVE--DVNDNAPRF-FPSH---------CAVAVFDNTTVKTPVAVVFA 3137
Query: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD---G 486
+ ++ + F++ T T + L +P+ Q ++ A D
Sbjct: 3138 RDPDQGANAQVVYSLPDSAEGHFSIDAT--TGVIRLEKPLQVRPQAPLELTVRASDLGTP 3195
Query: 487 VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITY 546
+ S V + V+ D P F + V V D PG V+QL + + Y
Sbjct: 3196 IPLSTLGTVTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTRPGAE--KTGY 3253
Query: 547 EILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
++ G QG F ++ TG++ + ++ Y L+++ + + + + + TV + +
Sbjct: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKS--SSSLSDVTTVMVNI 3311
Query: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFN 662
N P +FPQ YS + E VG V+L + ATD +G ITY++ G+ F
Sbjct: 3312 TDVNEHRP-QFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
Query: 663 LSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYL 721
+ G L + KALDRE Y L + A+D G+P + I V DVNDN P F
Sbjct: 3371 IHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRF---F 3427
Query: 722 PRNLSVVEEEANAFVG----QVKATDPDAGINGQVH---YSLGNFNNLFRITSNGSIYTA 774
N S +E N+ +G Q+ +DPD+ NG + + GN + FR+T +G + TA
Sbjct: 3428 QLNYSTTVQE-NSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA 3486
Query: 775 VKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 834
L+R +++Y+L + A+D + P S ++ + V + +P + V E+
Sbjct: 3487 EGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQ 3546
Query: 835 GTTILQIEAKDVDLGANVSYRIRSPEV--KHF 864
G + +I A D D ++Y + E +HF
Sbjct: 3547 GGMVGKIHATDRDPQDTLTYSLAEEETLGRHF 3578
Score = 127 bits (319), Expect = 9e-29
Identities = 128/479 (26%), Positives = 212/479 (44%), Gaps = 34/479 (7%)
Query: 754 YSLGNFNNLFRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDID 813
Y +GNF L RI + S LNREVRD Y L++ AT+ + T + + +LD +
Sbjct: 87 YVVGNFCFL-RIRTKSS--NTALLNREVRDSYTLIIQATEKTLELEALT-RVVVHILDQN 142
Query: 814 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGE 873
D P+F+ +Y V + E++P + I ++ A D DLG N + FA+HP +G
Sbjct: 143 DLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGV 202
Query: 874 LSLLRSLDYEAFPDQEASITFLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSKRIYK 932
+++ L+ E + + I G +A + V V+ PP + +
Sbjct: 203 VTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVV-- 260
Query: 933 GMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRV 992
+ PD+ GT TV DA+ G V D + A + +++
Sbjct: 261 -VTPPDSNDGTTYATVLV-DANSSGAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVK 318
Query: 993 NLN-EEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIP--RFTQEEYRPPPVSELA 1049
++N E F L + A P S ++ L P ++ +F + YR +SE +
Sbjct: 319 DINWMEYLHGFNLSLQARSGSGPYFYSQ--IRGFHLPPSKLSSLKFEKAVYR-VQLSEFS 375
Query: 1050 TKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQA 1109
G+ V ++ ++ Y + +E F +N TG+I +D+ R Y L ++
Sbjct: 376 PPGSRVVMVRVTPAFPNLQYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRT 435
Query: 1110 DSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1169
P +++T V I+I D NNH P+F + Y G + E+ TSVL V AT
Sbjct: 436 S-----------PGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTAT 483
Query: 1170 DKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTA--MLFHNMRRSYFKFQVIATD 1226
D+D G + Y + P F ++ Y G+I T+ M + M+R Y F+V A+D
Sbjct: 484 DRDHGENGYVTYSIAGPKALP----FSIDPYLGIISTSKPMDYELMKRIY-TFRVRASD 537
Score = 77.0 bits (188), Expect = 1e-13
Identities = 145/656 (22%), Positives = 260/656 (39%), Gaps = 103/656 (15%)
Query: 647 SITYAIENGDPQRVFNLSETT-------GILTLGK---ALDRESTDRYILIITASDGRPD 696
++ Y I +GD VF E I T L+RE D Y LII A++ +
Sbjct: 68 AVRYRIISGDVANVFKTEEYVVGNFCFLRIRTKSSNTALLNREVRDSYTLIIQATEKTLE 127
Query: 697 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL 756
+ V + + D ND P+F P R + + + +V ATD D G N + +Y+
Sbjct: 128 LEALTRVVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAF 187
Query: 757 GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATD--GAVHPRHSTLTLAIKVLDID 813
+ +F I ++G + A KLN R +EL V+A D + + +LA V+ ++
Sbjct: 188 NTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE 247
Query: 814 D--------NSPVFT------NSTY-TVLVEENLPAGTTILQIEAKDVDLGANVSYRIRS 858
S V T +TY TVLV+ N +G + +E D G
Sbjct: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDAN-SSGAEVESVEVVGGDPG--------- 297
Query: 859 PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKD 918
KHF A+ S RS ++ ++ + + F++ ++
Sbjct: 298 ---KHFKAIK------SYARSNEFSLVSVKDINWMEYLHGFNL-------------SLQA 335
Query: 919 MNDYPPVFSKRIYKGMVAPDAVKG----TPITTVYAEDADPPGLPASRVRYRVDDVQFPY 974
+ P F +I + P + + V + PPG VR V +
Sbjct: 336 RSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYRVQLSEFSPPGSRVVMVR-----VTPAF 390
Query: 975 PASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDD---------GEPVMSSSATVKIL 1025
P + ++ S V ++N T KL + F D P +S+ V +
Sbjct: 391 PNLQYVLKPSSENVGFKLNARTGLITTTKL--MDFHDRAHYQLHIRTSPGQASTVVVIDI 448
Query: 1026 VLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFG 1081
V P F + Y + E GT V ++A N + YSI +G + F
Sbjct: 449 VDCNNHAPLFNRSSY-DGTLDENIPPGTSVLAVTATDRDHGENGYVTYSI-AGPKALPFS 506
Query: 1082 INNITGVIYVNGPLDYE-TRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNH 1140
I+ G+I + P+DYE + Y RV+A + +++++++ N++
Sbjct: 507 IDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPF------RREKEVSIFLQLRNLNDN 560
Query: 1141 PPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETY 1200
P+F++ G + +D + S++ + A D D + Y ++ E F + +
Sbjct: 561 QPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVD--ELQNLKYEIV---SGNELEYFDLNHF 615
Query: 1201 TGLIKTAMLFHNM---RRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS 1253
+G+I F N+ + + + ++ A+D GK + + ++VV +V V+
Sbjct: 616 SGVISLKRPFINLTAGQPTSYSLKITASD--GKNYASPTTLNITVVKDPHFEVPVT 669
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 221 bits (562), Expect = 6e-57
Identities = 249/939 (26%), Positives = 395/939 (42%), Gaps = 123/939 (13%)
Query: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
FH+HP T + ++R+ + V L A + I + D N+ SP F +
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPRFPL 169
Query: 398 PSYQGYILESAPVGATI--------SDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYT 449
S Q + E +P G L T +V +D P L
Sbjct: 170 DSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
Query: 450 SVFTVTQTGITR-----YLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDA 502
+ + G + L LL+ +DREE + I A+DG + + + V ++V+D
Sbjct: 230 PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
Query: 503 NDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV----------GA 552
NDN P F + Y V D +PG V ++ A D D G NG + Y + GA
Sbjct: 290 NDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGA 349
Query: 553 QGD---FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 609
GD F + + +G++ + ++ + L V+A D AE + V I VL N
Sbjct: 350 LGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGG--AEPEVATVRVSIAVLDVN 407
Query: 610 NQSPPRFPQLMYS---LEISEAMRVGAVLLNLQATDREGD------------------SI 648
+ P + +SE R G + + +D +GD SI
Sbjct: 408 DNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSI 467
Query: 649 TYAIENGDPQRVFNLSETTGI--LTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705
+ ++E G+ G+ L + LDRES D Y L++ A+D G P ++ T+ +
Sbjct: 468 SLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLL 527
Query: 706 VVTDVNDNAPVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAG-----------INGQVH 753
V D+ND P+F SV E A V V A+D D +
Sbjct: 528 RVADLNDQPPLFSQQ-HYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAP 586
Query: 754 YSLGNFNN----------LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 802
+LG+ + F I S +G+I T L+REV++ EL VVA D P +T
Sbjct: 587 CNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSAT 646
Query: 803 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRI---- 856
++I V D++DN P+F Y + E+ P G LQ+ A D D G + Y +
Sbjct: 647 CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706
Query: 857 RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIV 916
S E F + P G++ + + +D E P A+ LVEA D G A V V +
Sbjct: 707 LSYEAPQAFRIDPHDGQICVSQDIDRERDP---ATYDLLVEAKDGGGLSAQ--AFVRVDL 761
Query: 917 KDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPA 976
+D+ND PVF+ Y ++ + GT I V A D D G+ + V Y + +
Sbjct: 762 EDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQD-SGIYGT-VAYELIPGNV---S 816
Query: 977 SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG--EPVMSSSATVKIL--VLHPGEI 1032
S+F ++ +G + + L+ +T L+V A D G V+++ T+ I L P E
Sbjct: 817 SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
Query: 1033 --PRFTQEEYRPPPVSELATKGTMVGVISA-AAINQS--IVYSIVSGNEEDTFGINNITG 1087
P++T Y P + + +G + A +N S I Y I SG+ F I+ G
Sbjct: 877 ERPKYTFLVYEDVP------EDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLG 930
Query: 1088 VIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKK 1147
I PLD+ET+ VL VQ A L ++ +V I + D N++ P F +
Sbjct: 931 TIRTRKPLDHETQPVVVLTVQ--------AQLGSAPACSSTEVNITVMDVNDNHPAFLRT 982
Query: 1148 FYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIP 1186
+S+ T++ +A D+D+G ++ Y + P
Sbjct: 983 SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP 1021
Score = 200 bits (509), Expect = 8e-51
Identities = 298/1218 (24%), Positives = 486/1218 (39%), Gaps = 176/1218 (14%)
Query: 125 VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGA-------- 176
+G ++ E+R V D ND+SP F +S V+EL+P GT + D A
Sbjct: 147 LGAVVQVEIR--VNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGY 204
Query: 177 -----TDIDDGPNGQIEYVIQY-------NPDDPTSNDTFEIPLMLTGNIVLRKRLNYED 224
+D+ P G + ++Y +P P S+ E PL ++VL +RL+ E+
Sbjct: 205 TLVQPSDLPKDPAGPF-FQLRYRTPGPLPSPLLPGSSSPLE-PL----DLVLLRRLDREE 258
Query: 225 KTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQA 284
+ + I+A D + RRT ++ + VLD +D P+F Y+A
Sbjct: 259 AAAHRLQIEAWDGGR---PRRTGLLSVELRVLDENDNPPVF------------EQDEYRA 303
Query: 285 AIPELRTPEELNPIIVTPPIQAIDQD-----------RNIQPPSDRPGILYSILVGTPED 333
A+ E+ P ++A D+D R Q P G G
Sbjct: 304 AV-----REDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSG-------GGALG 351
Query: 334 YPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSP 393
+F + + + + P++R+ LV++A P A + I +LD N+ P
Sbjct: 352 DAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRP 411
Query: 394 ----YFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPE--------- 440
F + E A G ++ R+ D D + K+ E
Sbjct: 412 AIHVLFLTEGGVARVSEGARPGDYVA---------RVSVSDADGDWEKEDEATGELGVGL 462
Query: 441 ----LHLFLNDYTSVFTVTQTGI--TRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEP 492
+ L L F + G +L + P+DRE + Y + A D S
Sbjct: 463 GDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTE 522
Query: 493 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN----------- 541
+ ++V D ND P F + Y V PG V+ ++A DADE +
Sbjct: 523 ETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQ 582
Query: 542 -------GEITYEILVGAQ--GDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 592
G + +++ A+ F I+ +G I+ ++ V L V A D P
Sbjct: 583 LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPP 642
Query: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG---DSIT 649
++ C V I V N + P F + +Y+ I+E VG L + A+D + I
Sbjct: 643 --LSATCLVSITV-DDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIE 699
Query: 650 YAIENG----DPQRVFNLSETTGILTLGKALDRE-STDRYILIITASDGRPDGTST-ATV 703
Y++ +G + + F + G + + + +DRE Y L++ A DG G S A V
Sbjct: 700 YSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG--GGLSAQAFV 757
Query: 704 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSL--GNFNN 761
+ + DVNDN PVF+P E + + V ATD D+GI G V Y L GN ++
Sbjct: 758 RVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSS 817
Query: 762 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 820
LF I S G IY + L+ L+V A DG + I + F
Sbjct: 818 LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877
Query: 821 NSTYTVLVEENLPAGTTILQIEAKD-VDLGANVSYRIRSPEVKHFFALHPFTGELSLLRS 879
YT LV E++P + I ++A++ ++ + YRI S ++ F++HP G + +
Sbjct: 878 RPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKP 937
Query: 880 LDYEAFPDQEASITFLVEAFDIYGTMPPGIAT-VTVIVKDMNDYPPVFSKRIYKGMVAPD 938
LD+E P + V+A G+ P +T V + V D+ND P F + + ++
Sbjct: 938 LDHETQP----VVVLTVQA--QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQT 991
Query: 939 AVKGTPITTVYAEDADP--PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNE 996
GT + AED D GL +RY + Q +F ++ G + +L
Sbjct: 992 TPPGTALYLARAEDRDSGRNGL----IRYSIASPQ----PGVFAIDRALGVLFLNGSLGA 1043
Query: 997 EPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQE---------EYRPPPVSE 1047
L + A D G ++ + +++ P +T E E P
Sbjct: 1044 GEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQM 1103
Query: 1048 LATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
L T+ +G AA+ + YS+ + FGI TG IY+ DYE+ +Y RV
Sbjct: 1104 LQTQAHPLGPQRAAS---PLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRV 1160
Query: 1108 QADSLE-VVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
A E L N+ + V + + DEN++ P F V E + ++
Sbjct: 1161 FAWIPEDGFLQNV-------STTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKI 1213
Query: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
A D D+G + Y L + +GK F + TG + + R + + V+ TD
Sbjct: 1214 TAIDMDSGKNGQLLYFL----LSDGK-FFKMNPNTGELINWVALDREHRGHHEMTVLVTD 1268
Query: 1227 DYGKGLSGKADVLVSVVN 1244
+ V VSV +
Sbjct: 1269 RGSPPRNATMAVYVSVTD 1286
Score = 189 bits (479), Expect = 3e-47
Identities = 209/782 (26%), Positives = 316/782 (40%), Gaps = 79/782 (10%)
Query: 98 STGRVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVN 157
ST R LDR+ + VV + V I V D NDN P F + Y AT+
Sbjct: 616 STIRTLDREVQEAVELKVVAQDLGEPPLSATCL--VSITVDDVNDNEPIFWRQVYNATIA 673
Query: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
E PVG A+D D G G IEY + + F I G I +
Sbjct: 674 EHAPVGHCFL-----QVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPH-DGQICVS 727
Query: 218 KRLNYE-DKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRD 276
+ ++ E D Y ++++A D + + VD+ D +D P+F P V + D
Sbjct: 728 QDIDRERDPATYDLLVEAKDGGG-----LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISD 782
Query: 277 CRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
E P + A DQD I + Y ++ P +
Sbjct: 783 -----------------ETQPGTEIINVLATDQDSGIYGT-----VAYELI---PGNVSS 817
Query: 337 FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFT 396
F + T + L P++ L++ A+ G A + I I F
Sbjct: 818 LFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFE 877
Query: 397 MPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV-T 455
P Y + E P SP+ V + + ++ + D F++
Sbjct: 878 RPKYTFLVYEDVPED----------SPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHP 927
Query: 456 QTGITRYLTLLQPVDREEQQTYTFSITAFDGVQES-EPVIVNIQVMDANDNTPTFPEISY 514
+ G R +P+D E Q ++ A G + VNI VMD NDN P F S
Sbjct: 928 RLGTIR---TRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSD 984
Query: 515 DVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMI 574
++ + PG ++ A D D G NG I Y I G F I++ G++ + +
Sbjct: 985 EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAG 1044
Query: 575 VGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP-RFPQLMYSLEISEAMRVGA 633
R LT++A D + + TV IE SP F L+Y +E+SE++
Sbjct: 1045 EQRELTLTLRAEDQGVHPQAALLVLTVVIE---KREHSPSWTFEHLVYQVEVSESLSPMT 1101
Query: 634 VLLNLQA----TDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIIT 689
+L QA R + Y++E +F + TG + L + D EST Y +
Sbjct: 1102 QMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVF 1161
Query: 690 A---SDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA---NAFVGQVKATD 743
A DG ST TV + V D NDN+P F L L + EE+ +G++ A D
Sbjct: 1162 AWIPEDGFLQNVST-TVIVRVWDENDNSPTF---LHDVLFLKVEESPVPQGVIGKITAID 1217
Query: 744 PDAGINGQVHYSLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 802
D+G NGQ+ Y L + F++ N G + V L+RE R ++E+ V+ TD PR++T
Sbjct: 1218 MDSGKNGQLLYFLLSDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNAT 1277
Query: 803 LTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLG--ANVSYRI 856
+ + + V DI+DN P F V V E P + + AKD D G A V+Y +
Sbjct: 1278 MAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Query: 857 RS 858
S
Sbjct: 1338 SS 1339
Score = 184 bits (468), Expect = 5e-46
Identities = 268/1131 (23%), Positives = 458/1131 (40%), Gaps = 159/1131 (14%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDN P F+ + Y A V E G + ATD D GPNG + Y ++
Sbjct: 282 VELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRV-----RATDRDLGPNGFVRYSVR 336
Query: 193 YNP-------DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
+ + L+G + + + L+ E + + ++++A D E
Sbjct: 337 ARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGA---EPE 393
Query: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPE---LRTPEELNPIIVTP 302
T +++ VLD D RP + + E R E P
Sbjct: 394 VATVRVSIAVLD----------------VNDNRPAIHVLFLTEGGVARVSEGARPGDYVA 437
Query: 303 PIQAIDQDRNIQPPSDRPGILY------SI---LVGTPEDYPRFFHMHPRTAELSLLEPV 353
+ D D + + + G L SI L G D+ P L + P+
Sbjct: 438 RVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPL 497
Query: 354 NRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGAT 413
+R+ ++L++ A PL L + + D N+Q P F+ Y+ + E+A G
Sbjct: 498 DRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTV 557
Query: 414 I-----SDS--------------LNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV 454
+ SD+ + L++P + +L + T + ++ + +
Sbjct: 558 VMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIST 617
Query: 455 TQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNTPTFPEI 512
+T +DRE Q+ + A D + S +V+I V D NDN P F
Sbjct: 618 IRT-----------LDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQ 666
Query: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-----AQGDFIINKTTGLITI 567
Y+ + G +Q+TA DAD G G I Y + G A F I+ G I +
Sbjct: 667 VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICV 726
Query: 568 APGVEMIVG-RTYALTVQAADNAPPAERRNSICTVYIEV-LPPNNQSPPRFPQLMYSLEI 625
+ ++ TY L V+A D + + ++ V L N + P F Y I
Sbjct: 727 SQDIDRERDPATYDLLVEAKDGGGLSAQ------AFVRVDLEDVNDNHPVFNPSTYVTSI 780
Query: 626 SEAMRVGAVLLNLQATDREG---DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTD 682
S+ + G ++N+ ATD++ ++ Y + G+ +F + TTGI+ L L +
Sbjct: 781 SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLEST 840
Query: 683 RYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYL-------PRNLSVVEEEA--N 733
L+++A DG G TA +N VT +F L P+ +V E+ +
Sbjct: 841 TLSLMVSAQDG---GGLTAVINADVT-----IHIFQTTLAPAEFERPKYTFLVYEDVPED 892
Query: 734 AFVGQVKATDPDAGINGQVHY--SLGNFNNLFRITSN-GSIYTAVKLNREVRDYYELVVV 790
+ +G VKA +P + + Y S G+ F I G+I T L+ E + L V
Sbjct: 893 SPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQ 951
Query: 791 ATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGA 850
A G+ P S+ + I V+D++DN P F ++ + + + P GT + A+D D G
Sbjct: 952 AQLGSA-PACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGR 1010
Query: 851 N--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPG 908
N + Y I SP+ FA+ G L L SL ++ +T + A D G P
Sbjct: 1011 NGLIRYSIASPQ-PGVFAIDRALGVLFLNGSLG----AGEQRELTLTLRAED-QGVHPQA 1064
Query: 909 IATVTVIVKDMNDYPP--VFSKRIYKGMVAPDAVKGTPITTVYAEDADP--PGLPASRVR 964
V +V + ++ P F +Y+ V+ +P+T + A P P AS +R
Sbjct: 1065 ALLVLTVVIEKREHSPSWTFEHLVYQVEVSESL---SPMTQMLQTQAHPLGPQRAASPLR 1121
Query: 965 YRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAF--DDGEPVMSSSATV 1022
Y ++ +++F + +G + R + E T + V A+ +DG + + S TV
Sbjct: 1122 YSLEP---SVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGF-LQNVSTTV 1177
Query: 1023 KILVLHPGE-IPRFTQE------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVSGN 1075
+ V + P F + E P P + G + + + N ++Y ++S
Sbjct: 1178 IVRVWDENDNSPTFLHDVLFLKVEESPVPQGVI---GKITAIDMDSGKNGQLLYFLLSDG 1234
Query: 1076 EEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQ 1135
+ F +N TG + LD E R + + V++ + P ++ T VY+ +
Sbjct: 1235 K--FFKMNPNTGELINWVALDREHRGHH-------EMTVLVTDRGSPPRNATMAVYVSVT 1285
Query: 1136 DENNHPPVFQ-----KKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1181
D N++ P F K+ ++ V E + V V A D D GN + + Y
Sbjct: 1286 DINDNRPFFPQCLPGKELHV-KVLEGQPVNMLVTTVFAKDPDEGNNAEVTY 1335
Score = 147 bits (372), Expect = 6e-35
Identities = 185/746 (24%), Positives = 315/746 (42%), Gaps = 122/746 (16%)
Query: 631 VGAVLLNLQATDREGDSITYAIENGDPQRV---FNLSETTGILTLGKALDRESTDRYILI 687
VG + L A ++ S + E+ D + F++ TGI+ + LDRE D Y +
Sbjct: 83 VGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLDRERRDHYSFV 142
Query: 688 ITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANAFVGQVKATDPDA 746
G + V I V DVND++P F L ++S + AF V A DPDA
Sbjct: 143 AATLLG-----AVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPV-AHDPDA 196
Query: 747 GINGQVHYSLGNFNNL----------FRITSNGSIYTAV-----------------KLNR 779
G+ Y+L ++L R + G + + + +L+R
Sbjct: 197 GLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDR 256
Query: 780 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
E + L + A DG R L++ ++VLD +DN PVF Y V E+ G +
Sbjct: 257 EEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVC 316
Query: 840 QIEAKDVDLGAN--VSYRIRSPEV------------KHFFALHPFTGELSLLRSLDYEAF 885
++ A D DLG N V Y +R+ +V +FA+ +G + + R LD EA
Sbjct: 317 RVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREA- 375
Query: 886 PDQEASITFLVEAFDIYGTMPPGIAT--VTVIVKDMNDYPP----VFSKRIYKGMVAPDA 939
+A +VEA D G P +AT V++ V D+ND P +F V+ A
Sbjct: 376 ---QAWHQLVVEARD--GGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGA 430
Query: 940 VKGTPITTVYAEDADPP-------------GLPASRVRYRVDDVQFPY------PASIFE 980
G + V DAD GL + ++ + + P +F
Sbjct: 431 RPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVF- 489
Query: 981 VEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEY 1040
+ L+ E +++L++VA D G P +S+ T+ + V + P +++
Sbjct: 490 ------FLCVEGPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQH 543
Query: 1041 RPPPVSELATKGTMVGVISAAAINQS------IVYSIVS-------GNEED--------- 1078
VSE A GT+V +SA+ +++ + Y++V G+ +
Sbjct: 544 YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECG 603
Query: 1079 -TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDE 1137
+F I++ +G I LD E + +A L+VV +L P S T V I + D
Sbjct: 604 PSFAIDSESGAISTIRTLDREVQ-------EAVELKVVAQDLGEPPLSATCLVSITVDDV 656
Query: 1138 NNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK-EGKEGFV 1196
N++ P+F ++ Y ++E A + L+V A+D D+G Y + Y L + E + F
Sbjct: 657 NDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSYEAPQAFR 716
Query: 1197 VETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVS-NV 1255
++ + G I + + R + ++ G GLS +A V V + + D + + +
Sbjct: 717 IDPHDGQICVSQDI-DRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHPVFNPST 775
Query: 1256 PPTLVEKKIEDLTEILDRYVQEQIPG 1281
T + + + TEI++ +Q G
Sbjct: 776 YVTSISDETQPGTEIINVLATDQDSG 801
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 206 bits (525), Expect = 1e-52
Identities = 174/572 (30%), Positives = 269/572 (47%), Gaps = 34/572 (5%)
Query: 463 LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 520
L + Q +DRE++ TY I DG Q+S I+ + V D NDN P F E +V++
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 521 DMRPGDSVIQLTAVDADEGSNGEITY----EILVGAQGDFIINKTTGLITIAPGVEMIVG 576
+ G SVIQL A DAD GSN EI Y ++ + F +N TTGLIT+ ++
Sbjct: 264 NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323
Query: 577 RTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 635
+ +TV A+D ++ PA +I + PPN + ++ +SE V +
Sbjct: 324 AIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383
Query: 636 LNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 692
+ +D++ D + IE P + + + +L LD E T + I ASD
Sbjct: 384 ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASD 443
Query: 693 -GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANA-FVGQVKATDPDAGIN 749
G+P TA V + + D NDN P+F+ P + LSV E ++ + ATD D+G N
Sbjct: 444 SGKPSLNQTALVRVKLEDENDNPPIFNQPVI--ELSVSENNRRGLYLTTISATDEDSGKN 501
Query: 750 GQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
+ Y LG + F + + TA ++ +RE ++ + V A D P S + +
Sbjct: 502 ADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561
Query: 809 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 868
VLD +DNSP FT++ + V ENLP +T+ I D D G N + + F L
Sbjct: 562 VLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLD 621
Query: 869 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 926
P++G + S D E Q++S TF V+A D G PP A VT+ V D+ND PV
Sbjct: 622 PYSGVIKSNVSFDRE----QQSSYTFDVKATD--GGQPPRSSTAKVTINVMDVNDNSPVV 675
Query: 927 ----SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
S +K +V A+ G+ + V+A D D G+ A ++Y + +F ++
Sbjct: 676 ISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVD-TGMNA-ELKYTIVSGN---NKGLFRID 729
Query: 983 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
+G + + +LVV D G P
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 203 bits (516), Expect = 1e-51
Identities = 193/711 (27%), Positives = 316/711 (44%), Gaps = 87/711 (12%)
Query: 618 QLMYSL--EISEAMRVGAV-----LLNLQATDREGDSITYAIEN--GDPQRVFNLSETTG 668
+L+Y++ E+ E + +G + + ++ A S+ Y + + GD V S T
Sbjct: 25 ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84
Query: 669 ILTLGKALDREST--------------DRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
I T +DRE + ++I+ D + I+V D NDNA
Sbjct: 85 IFTTSNRIDREKLCAGASYAEENECFFELEVVILPN-----DFFRLIKIKIIVKDTNDNA 139
Query: 715 PVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNG 769
P+F P N+S+ E N+ ATDPD G NG HY L N ++F + T G
Sbjct: 140 PMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEG 198
Query: 770 SIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 825
+ + L+RE +D Y + + DG + ST L + V D++DN PVF
Sbjct: 199 EKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVE 258
Query: 826 VLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALHPFTGELSLLRSL 880
V + EN P GT+++Q+ A D D+G+N R +P K FAL+ TG +++ RSL
Sbjct: 259 VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318
Query: 881 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 940
D E + A V A D G+ P ATVT+ V D+ND PP R +++P +
Sbjct: 319 DRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRY---IISP--I 367
Query: 941 KGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASIFEVEEDSGRVIT 990
G TVY + DP + + D ++ P + V ++ + T
Sbjct: 368 NG----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 991 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELAT 1050
L+ E T F +VA D G+P ++ +A V++ + + P + VSE
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 1051 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1106
+G + ISA + N IVY + G F ++ TGV+ + D E + ++
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1107 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
V A + P + A V + + DEN++ P F + VSE+ +++V +
Sbjct: 542 VTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
TD D G + ++ + FV++ Y+G+IK+ + F ++S + F V ATD
Sbjct: 595 TVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 1227 DYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQE 1277
S A V ++V++ D +V + PP+ K+ L+ I V E
Sbjct: 650 GGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAE 699
Score = 182 bits (461), Expect = 3e-45
Identities = 162/563 (28%), Positives = 256/563 (45%), Gaps = 64/563 (11%)
Query: 349 LLEPVNRDFHQKFDLVIKAE-QDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILE 406
L+ N D QK V+K + +D G P + L + + D N+ P F + +I E
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 407 SAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS-----VFTVTQTGITR 461
+APVG TS +++ A D DI + E+ + +F + T T
Sbjct: 264 NAPVG---------TSVIQLHATDADI--GSNAEIRYIFGAQVAPATKRLFALNNT--TG 310
Query: 462 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT------FPEISYD 515
+T+ + +DREE + ++ A DG V I V D NDN P I+
Sbjct: 311 LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370
Query: 516 VYVYTDMRPGDSVIQLTAVDADEGSNG--------EITYEILVGAQGDFIINKTTGLITI 567
VY+ + +T D D NG E+ + + +++ +T+ L+
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL-ETSSLLDY 429
Query: 568 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 627
E ++ + A+D+ P+ + ++ V +E N +PP F Q + L +SE
Sbjct: 430 EGTKE------FSFKIVASDSGKPSLNQTALVRVKLE---DENDNPPIFNQPVIELSVSE 480
Query: 628 AMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 686
R G L + ATD + G + + G F+L TG+LT + DRE +R+I
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540
Query: 687 IITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVK 740
+TA D G P S A V + V D NDN+P F ++ NL + VG +
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL-----PKYSTVGVIT 595
Query: 741 ATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPR 799
TD DAG N V S+ N N+ F + +G I + V +RE + Y V ATDG PR
Sbjct: 596 VTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
Query: 800 HSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 853
ST + I V+D++DNSPV +N+++ ++ +P G+ + ++ A DVD G N +
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELK 714
Query: 854 YRIRSPEVKHFFALHPFTGELSL 876
Y I S K F + P TG ++L
Sbjct: 715 YTIVSGNNKGLFRIDPVTGNITL 737
Score = 167 bits (424), Expect = 6e-41
Identities = 177/626 (28%), Positives = 275/626 (43%), Gaps = 49/626 (7%)
Query: 495 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ- 553
+ I V D NDN P FP ++ + + +A D D G NG YE+L G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 554 -GDFIINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
G I+ G + + ++ TY + ++ D P + +I V + +
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV-- 245
Query: 609 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS------ITYAIENGDPQRVFN 662
N + P F + + I E VG ++ L ATD + S I A +R+F
Sbjct: 246 -NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 663 LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYL 721
L+ TTG++T+ ++LDRE T + + + ASDG + ATV I VTDVNDN P D Y+
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVNDNPPNIDLRYI 363
Query: 722 --PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNLFRITSNGSIYT 773
P N +V E N + + +D D +NG+V + F+ + + T
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
+ L+ E + +VA+D + T + +K+ D +DN P+F + V EN
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
G + I A D D G N + FF L TG L+ R D E +QE I
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE---EQERFI- 539
Query: 894 FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
F V A D GT P A V V V D ND P F+ ++ V+ + K + + + D
Sbjct: 540 FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598
Query: 953 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
AD A + D+ F ++ SG + + V+ + E + + V A D G
Sbjct: 599 ADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 1013 EPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAI---- 1063
+P SS+A V I V+ P I + ++ P+S A G++V + A +
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVAEVFAVDVDTGM 709
Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVI 1089
N + Y+IVSGN + F I+ +TG I
Sbjct: 710 NAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 141 bits (356), Expect = 5e-33
Identities = 168/650 (25%), Positives = 282/650 (43%), Gaps = 64/650 (9%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+++I+V+D NDN+P F +N P T I + F + ATD D G NG Y +
Sbjct: 127 KIKIIVKDTNDNAPMFPS----PVINISIPENTLINSRFPIPS-ATDPDTGFNGVQHYEL 181
Query: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
N D E P +++++ L+ E K Y + I+ D ++++T
Sbjct: 182 -LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAI 237
Query: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
L V V D +D P+F + E+ PE N + T IQ D
Sbjct: 238 LQVTVSDVNDNRPVF-----------------KEGQVEVHIPE--NAPVGTSVIQLHATD 278
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
+I ++ I Y R F ++ T +++ ++R+ + + A
Sbjct: 279 ADIGSNAE---IRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA--S 333
Query: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRI 426
+G PA A + I + D N+ P + YI+ +P+ T+ D +N T I
Sbjct: 334 DGSSTPARATVTINVTDVNDNPPNIDL----RYII--SPINGTVYLSEKDPVN-TKIALI 386
Query: 427 VALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 486
DKD + + ++ F+ L +D E + ++F I A D
Sbjct: 387 TVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDS 444
Query: 487 VQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
+ S + +V +++ D NDN P F + ++ V + R G + ++A D D G N +I
Sbjct: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504
Query: 545 TYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Y++ A F +++ TG++T + + + TV A DN P S V +
Sbjct: 505 VYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP--LQSQAAVIVT 561
Query: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 661
VL N+ S P+F + +SE + + + + TD E ++T +I N + F
Sbjct: 562 VLDENDNS-PKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN--F 618
Query: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-VFDP 719
L +G++ + DRE Y + A+D G+P +STA V I V DVNDN+P V P
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISP 678
Query: 720 YLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI 765
+ +V A + V +V A D D G+N ++ Y++ GN LFRI
Sbjct: 679 PSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRI 728
Score = 102 bits (253), Expect = 4e-21
Identities = 88/310 (28%), Positives = 138/310 (44%), Gaps = 38/310 (12%)
Query: 278 RPLTYQAAIPELRTPEEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
+P Q A+ ++ +E NP I P+ + N +R G+ + + T ED +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGK 500
Query: 337 -------------FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
FF + +T L+ +R+ ++F + A + PL + A + +
Sbjct: 501 NADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560
Query: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
+LDEN+ SP FT +Q ++ E+ P +T+ I D D + K L +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI 611
Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVIVNIQVMD 501
LND + +G+ + DRE+Q +YTF + A DG Q S V I VMD
Sbjct: 612 -LNDNDNFVLDPYSGVIKSNV---SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667
Query: 502 ANDNTPTF---PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFI 557
NDN+P P + V PG V ++ AVD D G N E+ Y I+ G +G F
Sbjct: 668 VNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFR 727
Query: 558 INKTTGLITI 567
I+ TG IT+
Sbjct: 728 IDPVTGNITL 737
Score = 50.8 bits (120), Expect = 1e-05
Identities = 74/310 (23%), Positives = 118/310 (38%), Gaps = 64/310 (20%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDNSP F H + V+E P +T+ G TD D G N + I
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV-----GVITVTDADAGENKAVTLSIL 612
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
ND F + +G I + E ++ Y ++A D Q R++T +T
Sbjct: 613 ------NDNDNFVLD-PYSGVIKSNVSFDREQQSSYTFDVKATDGGQ---PPRSSTAKVT 662
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
++V+D +D P+ V+ P + L +AIP V + A+D D
Sbjct: 663 INVMDVNDNSPV----VISPPSNTSFKLVPLSAIPG----------SVVAEVFAVDVDTG 708
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
+ + Y+I+ G + F + P T ++L E
Sbjct: 709 MNAE-----LKYTIVSGNNKG---LFRIDPVTGNITLEE--------------------- 739
Query: 373 HPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
P P GLH + I D T+ Y+ ++A + I D + T L
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTME---TPL 796
Query: 430 DKDIEDTKDP 439
D++I D+ P
Sbjct: 797 DRNIGDSSQP 806
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 206 bits (525), Expect = 1e-52
Identities = 174/572 (30%), Positives = 269/572 (47%), Gaps = 34/572 (5%)
Query: 463 LTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 520
L + Q +DRE++ TY I DG Q+S I+ + V D NDN P F E +V++
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 521 DMRPGDSVIQLTAVDADEGSNGEITY----EILVGAQGDFIINKTTGLITIAPGVEMIVG 576
+ G SVIQL A DAD GSN EI Y ++ + F +N TTGLIT+ ++
Sbjct: 264 NAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREET 323
Query: 577 RTYALTVQAAD-NAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVL 635
+ +TV A+D ++ PA +I + PPN + ++ +SE V +
Sbjct: 324 AIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKI 383
Query: 636 LNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD 692
+ +D++ D + IE P + + + +L LD E T + I ASD
Sbjct: 384 ALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASD 443
Query: 693 -GRPDGTSTATVNIVVTDVNDNAPVFD-PYLPRNLSVVEEEANA-FVGQVKATDPDAGIN 749
G+P TA V + + D NDN P+F+ P + LSV E ++ + ATD D+G N
Sbjct: 444 SGKPSLNQTALVRVKLEDENDNPPIFNQPVI--ELSVSENNRRGLYLTTISATDEDSGKN 501
Query: 750 GQVHYSLGNFNNLFRITSNGSIYTAVKL-NREVRDYYELVVVATDGAVHPRHSTLTLAIK 808
+ Y LG + F + + TA ++ +RE ++ + V A D P S + +
Sbjct: 502 ADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVT 561
Query: 809 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALH 868
VLD +DNSP FT++ + V ENLP +T+ I D D G N + + F L
Sbjct: 562 VLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLD 621
Query: 869 PFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVF 926
P++G + S D E Q++S TF V+A D G PP A VT+ V D+ND PV
Sbjct: 622 PYSGVIKSNVSFDRE----QQSSYTFDVKATD--GGQPPRSSTAKVTINVMDVNDNSPVV 675
Query: 927 ----SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 982
S +K +V A+ G+ + V+A D D G+ A ++Y + +F ++
Sbjct: 676 ISPPSNTSFK-LVPLSAIPGSVVAEVFAVDVD-TGMNA-ELKYTIVSGN---NKGLFRID 729
Query: 983 EDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP 1014
+G + + +LVV D G P
Sbjct: 730 PVTGNITLEEKPAPTDVGLHRLVVNISDLGYP 761
Score = 203 bits (516), Expect = 1e-51
Identities = 193/711 (27%), Positives = 316/711 (44%), Gaps = 87/711 (12%)
Query: 618 QLMYSL--EISEAMRVGAV-----LLNLQATDREGDSITYAIEN--GDPQRVFNLSETTG 668
+L+Y++ E+ E + +G + + ++ A S+ Y + + GD V S T
Sbjct: 25 ELIYTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGE 84
Query: 669 ILTLGKALDREST--------------DRYILIITASDGRPDGTSTATVNIVVTDVNDNA 714
I T +DRE + ++I+ D + I+V D NDNA
Sbjct: 85 IFTTSNRIDREKLCAGASYAEENECFFELEVVILPN-----DFFRLIKIKIIVKDTNDNA 139
Query: 715 PVFDPYLPRNLSVVEEEA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNG 769
P+F P N+S+ E N+ ATDPD G NG HY L N ++F + T G
Sbjct: 140 PMF-PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEG 198
Query: 770 SIYTAV----KLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYT 825
+ + L+RE +D Y + + DG + ST L + V D++DN PVF
Sbjct: 199 EKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVE 258
Query: 826 VLVEENLPAGTTILQIEAKDVDLGANVSYRI-----RSPEVKHFFALHPFTGELSLLRSL 880
V + EN P GT+++Q+ A D D+G+N R +P K FAL+ TG +++ RSL
Sbjct: 259 VHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSL 318
Query: 881 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV 940
D E + A V A D G+ P ATVT+ V D+ND PP R +++P +
Sbjct: 319 DRE----ETAIHKVTVLASD--GSSTPARATVTINVTDVNDNPPNIDLRY---IISP--I 367
Query: 941 KGTPITTVYAEDADPPGLPASRVRYRVDD----------VQFPYPASIFEVEEDSGRVIT 990
G TVY + DP + + D ++ P + V ++ + T
Sbjct: 368 NG----TVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 991 RVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELAT 1050
L+ E T F +VA D G+P ++ +A V++ + + P + VSE
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 1051 KGTMVGVISA----AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLR 1106
+G + ISA + N IVY + G F ++ TGV+ + D E + ++
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREEQERFIFT 541
Query: 1107 VQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
V A + P + A V + + DEN++ P F + VSE+ +++V +
Sbjct: 542 VTA-------RDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVI 594
Query: 1167 KATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATD 1226
TD D G + ++ + FV++ Y+G+IK+ + F ++S + F V ATD
Sbjct: 595 TVTDADAGENKAVTLSIL-----NDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATD 649
Query: 1227 DYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQE 1277
S A V ++V++ D +V + PP+ K+ L+ I V E
Sbjct: 650 GGQPPRSSTAKVTINVMDVNDNSPVVIS-PPSNTSFKLVPLSAIPGSVVAE 699
Score = 182 bits (461), Expect = 3e-45
Identities = 162/563 (28%), Positives = 256/563 (45%), Gaps = 64/563 (11%)
Query: 349 LLEPVNRDFHQKFDLVIKAE-QDNGHPLPAFAG-LHIEILDENNQSPYFTMPSYQGYILE 406
L+ N D QK V+K + +D G P + L + + D N+ P F + +I E
Sbjct: 204 LIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPE 263
Query: 407 SAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTS-----VFTVTQTGITR 461
+APVG TS +++ A D DI + E+ + +F + T T
Sbjct: 264 NAPVG---------TSVIQLHATDADI--GSNAEIRYIFGAQVAPATKRLFALNNT--TG 310
Query: 462 YLTLLQPVDREEQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPT------FPEISYD 515
+T+ + +DREE + ++ A DG V I V D NDN P I+
Sbjct: 311 LITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGT 370
Query: 516 VYVYTDMRPGDSVIQLTAVDADEGSNG--------EITYEILVGAQGDFIINKTTGLITI 567
VY+ + +T D D NG E+ + + +++ +T+ L+
Sbjct: 371 VYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLL-ETSSLLDY 429
Query: 568 APGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISE 627
E ++ + A+D+ P+ + ++ V +E N +PP F Q + L +SE
Sbjct: 430 EGTKE------FSFKIVASDSGKPSLNQTALVRVKLE---DENDNPPIFNQPVIELSVSE 480
Query: 628 AMRVGAVLLNLQATDRE-GDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 686
R G L + ATD + G + + G F+L TG+LT + DRE +R+I
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIF 540
Query: 687 IITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP-----YLPRNLSVVEEEANAFVGQVK 740
+TA D G P S A V + V D NDN+P F ++ NL + VG +
Sbjct: 541 TVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENL-----PKYSTVGVIT 595
Query: 741 ATDPDAGINGQVHYSLGNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPR 799
TD DAG N V S+ N N+ F + +G I + V +RE + Y V ATDG PR
Sbjct: 596 VTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
Query: 800 HSTLTLAIKVLDIDDNSPVF----TNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VS 853
ST + I V+D++DNSPV +N+++ ++ +P G+ + ++ A DVD G N +
Sbjct: 656 SSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIP-GSVVAEVFAVDVDTGMNAELK 714
Query: 854 YRIRSPEVKHFFALHPFTGELSL 876
Y I S K F + P TG ++L
Sbjct: 715 YTIVSGNNKGLFRIDPVTGNITL 737
Score = 167 bits (424), Expect = 6e-41
Identities = 177/626 (28%), Positives = 275/626 (43%), Gaps = 49/626 (7%)
Query: 495 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ- 553
+ I V D NDN P FP ++ + + +A D D G NG YE+L G
Sbjct: 128 IKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSV 187
Query: 554 -GDFIINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 608
G I+ G + + ++ TY + ++ D P + +I V + +
Sbjct: 188 FGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDV-- 245
Query: 609 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS------ITYAIENGDPQRVFN 662
N + P F + + I E VG ++ L ATD + S I A +R+F
Sbjct: 246 -NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFA 304
Query: 663 LSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD-PYL 721
L+ TTG++T+ ++LDRE T + + + ASDG + ATV I VTDVNDN P D Y+
Sbjct: 305 LNNTTGLITVQRSLDREETAIHKVTVLASDGSST-PARATVTINVTDVNDNPPNIDLRYI 363
Query: 722 --PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---FNNLFRITSNGSIYT 773
P N +V E N + + +D D +NG+V + F+ + + T
Sbjct: 364 ISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLET 423
Query: 774 AVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLP 833
+ L+ E + +VA+D + T + +K+ D +DN P+F + V EN
Sbjct: 424 SSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNR 483
Query: 834 AGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 893
G + I A D D G N + FF L TG L+ R D E +QE I
Sbjct: 484 RGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDRE---EQERFI- 539
Query: 894 FLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAED 952
F V A D GT P A V V V D ND P F+ ++ V+ + K + + + D
Sbjct: 540 FTVTARD-NGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598
Query: 953 ADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDG 1012
AD A + D+ F ++ SG + + V+ + E + + V A D G
Sbjct: 599 ADAGENKAVTLSILNDNDNFV-------LDPYSGVIKSNVSFDREQQSSYTFDVKATDGG 651
Query: 1013 EPVMSSSATVKILVLH-----PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAI---- 1063
+P SS+A V I V+ P I + ++ P+S A G++V + A +
Sbjct: 652 QPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLS--AIPGSVVAEVFAVDVDTGM 709
Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVI 1089
N + Y+IVSGN + F I+ +TG I
Sbjct: 710 NAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 141 bits (356), Expect = 5e-33
Identities = 168/650 (25%), Positives = 282/650 (43%), Gaps = 64/650 (9%)
Query: 132 EVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
+++I+V+D NDN+P F +N P T I + F + ATD D G NG Y +
Sbjct: 127 KIKIIVKDTNDNAPMFPS----PVINISIPENTLINSRFPIPS-ATDPDTGFNGVQHYEL 181
Query: 192 QYNPDDPTSNDTFEIPL-MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTT 250
N D E P +++++ L+ E K Y + I+ D ++++T
Sbjct: 182 -LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGG---TPQKSSTAI 237
Query: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
L V V D +D P+F + E+ PE N + T IQ D
Sbjct: 238 LQVTVSDVNDNRPVF-----------------KEGQVEVHIPE--NAPVGTSVIQLHATD 278
Query: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQD 370
+I ++ I Y R F ++ T +++ ++R+ + + A
Sbjct: 279 ADIGSNAE---IRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA--S 333
Query: 371 NGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATI----SDSLNLTSPLRI 426
+G PA A + I + D N+ P + YI+ +P+ T+ D +N T I
Sbjct: 334 DGSSTPARATVTINVTDVNDNPPNIDL----RYII--SPINGTVYLSEKDPVN-TKIALI 386
Query: 427 VALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 486
DKD + + ++ F+ L +D E + ++F I A D
Sbjct: 387 TVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDS 444
Query: 487 VQES--EPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
+ S + +V +++ D NDN P F + ++ V + R G + ++A D D G N +I
Sbjct: 445 GKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADI 504
Query: 545 TYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIE 604
Y++ A F +++ TG++T + + + TV A DN P S V +
Sbjct: 505 VYQLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPP--LQSQAAVIVT 561
Query: 605 VLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVF 661
VL N+ S P+F + +SE + + + + TD E ++T +I N + F
Sbjct: 562 VLDENDNS-PKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN--F 618
Query: 662 NLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAP-VFDP 719
L +G++ + DRE Y + A+D G+P +STA V I V DVNDN+P V P
Sbjct: 619 VLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISP 678
Query: 720 YLPRNLSVVEEEA--NAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI 765
+ +V A + V +V A D D G+N ++ Y++ GN LFRI
Sbjct: 679 PSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRI 728
Score = 102 bits (253), Expect = 4e-21
Identities = 88/310 (28%), Positives = 138/310 (44%), Gaps = 38/310 (12%)
Query: 278 RPLTYQAAIPELRTPEEL-NPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPR 336
+P Q A+ ++ +E NP I P+ + N +R G+ + + T ED +
Sbjct: 446 KPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSEN-----NRRGLYLTTISATDEDSGK 500
Query: 337 -------------FFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
FF + +T L+ +R+ ++F + A + PL + A + +
Sbjct: 501 NADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIV 560
Query: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
+LDEN+ SP FT +Q ++ E+ P +T+ I D D + K L +
Sbjct: 561 TVLDENDNSPKFTHNHFQFFVSENLPKYSTVG---------VITVTDADAGENKAVTLSI 611
Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQ--ESEPVIVNIQVMD 501
LND + +G+ + DRE+Q +YTF + A DG Q S V I VMD
Sbjct: 612 -LNDNDNFVLDPYSGVIKSNV---SFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMD 667
Query: 502 ANDNTPTF---PEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVG-AQGDFI 557
NDN+P P + V PG V ++ AVD D G N E+ Y I+ G +G F
Sbjct: 668 VNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFR 727
Query: 558 INKTTGLITI 567
I+ TG IT+
Sbjct: 728 IDPVTGNITL 737
Score = 50.8 bits (120), Expect = 1e-05
Identities = 74/310 (23%), Positives = 118/310 (38%), Gaps = 64/310 (20%)
Query: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
V + V D NDNSP F H + V+E P +T+ G TD D G N + I
Sbjct: 558 VIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTV-----GVITVTDADAGENKAVTLSIL 612
Query: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
ND F + +G I + E ++ Y ++A D Q R++T +T
Sbjct: 613 ------NDNDNFVLD-PYSGVIKSNVSFDREQQSSYTFDVKATDGGQ---PPRSSTAKVT 662
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
++V+D +D P+ V+ P + L +AIP V + A+D D
Sbjct: 663 INVMDVNDNSPV----VISPPSNTSFKLVPLSAIPG----------SVVAEVFAVDVDTG 708
Query: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNG 372
+ + Y+I+ G + F + P T ++L E
Sbjct: 709 MNAE-----LKYTIVSGNNKG---LFRIDPVTGNITLEE--------------------- 739
Query: 373 HPLPAFAGLH---IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
P P GLH + I D T+ Y+ ++A + I D + T L
Sbjct: 740 KPAPTDVGLHRLVVNISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTME---TPL 796
Query: 430 DKDIEDTKDP 439
D++I D+ P
Sbjct: 797 DRNIGDSSQP 806
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 198 bits (504), Expect = 3e-50
Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)
Query: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 299
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 25 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 84
Query: 300 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 359
+ Q + + D P L+ ED F R L + RD H
Sbjct: 85 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 138
Query: 360 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 139 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 191
Query: 420 LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 478
L + V D I ++ EL N + V + L + + +DREE+ TY
Sbjct: 192 LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 248
Query: 479 FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
+ DG Q S I+ + V D NDN P F E +V + + G SV QL A DA
Sbjct: 249 MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 308
Query: 537 DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 592
D G N +I + LV A+ F +N TTGLITI ++ + L V A+D
Sbjct: 309 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 368
Query: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 647
R V + V N+ P + + + + +SE + + + + TD++ D
Sbjct: 369 AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424
Query: 648 ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 703
+T ++ P R+ + +L LD EST Y + + A+D G+P +A +
Sbjct: 425 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 484
Query: 704 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 761
I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y LG +
Sbjct: 485 FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 543
Query: 762 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 820
F + + T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT
Sbjct: 544 EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 603
Query: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 880
++ Y V ENLP T+ I D D G N + + + F + TG + S
Sbjct: 604 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 881 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 937
D E ++ S TF V+A D A VT+ V D+ND PVF Y +V P
Sbjct: 664 DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 719
Query: 938 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
GT + V A D D G+ A VRY + +F +++++G + +
Sbjct: 720 STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 774
Query: 998 PTTIFKLVVVAFDDGEP 1014
+ +++V A D G+P
Sbjct: 775 DLGLHRVLVKANDLGQP 791
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 493 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 155 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 213
Query: 553 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 271
Query: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 659
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 272 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 718
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 389
Query: 719 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 764
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 390 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 765 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 824
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 450 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503
Query: 825 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 883
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 941
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 564 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 617
Query: 942 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 618 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 670
Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1054
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 671 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730
Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1112
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 731 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 790
Query: 1113 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
VV+ NL V A + E+ ++ PV
Sbjct: 791 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826
Score = 172 bits (436), Expect = 2e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 624 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 677
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 65 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 124
Query: 678 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 125 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 183
Query: 731 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 781
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 184 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243
Query: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 244 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 303
Query: 842 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 304 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 359
Query: 897 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 950
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 360 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417
Query: 951 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 418 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 470
Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1063
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 471 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 529
Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 530 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 581
Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 582 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641
Query: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1243
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 642 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696
Query: 1244 NQLDMQVIVSNVPP 1257
+ D + + VPP
Sbjct: 697 DVNDNKPVFI-VPP 709
Score = 168 bits (426), Expect = 4e-41
Identities = 188/769 (24%), Positives = 328/769 (42%), Gaps = 82/769 (10%)
Query: 98 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 118 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 172
Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 210
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 173 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 229
Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 230 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 281
Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
+ + +IPE N + T Q D +I + I +S
Sbjct: 282 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 324
Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 390
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 325 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 382
Query: 391 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYT 449
P + YI+ +S+++ L + + ++ + DKD + D+
Sbjct: 383 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHE 435
Query: 450 SVFTVTQTGITRY-LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNT 506
F + ++ L +D E + Y + A D + ++ ++ I+V D NDN
Sbjct: 436 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495
Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 566
P F + V + + PG +++++A DAD G N EI Y + A +F +++ TG++T
Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLT 555
Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
+ ++ Y T+ A DN P N TV++ ++ N+ SP F Y +
Sbjct: 556 VVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVP 612
Query: 627 EAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYI 685
E + R G V L GD+ + D F + TG++ + DRE + Y
Sbjct: 613 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 672
Query: 686 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKA 741
+ A D GR +S+A V I V DVNDN PVF PY L + V QV A
Sbjct: 673 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 732
Query: 742 TDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHP 798
D D G+N +V YS+ GN +LF I G+I K + TD +H
Sbjct: 733 VDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VTDLGLH- 779
Query: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 847
+ +K D+ +F+ + V E++ T I ++ K ++
Sbjct: 780 -----RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 823
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 198 bits (504), Expect = 3e-50
Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)
Query: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 299
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 25 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 84
Query: 300 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 359
+ Q + + D P L+ ED F R L + RD H
Sbjct: 85 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 138
Query: 360 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 139 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 191
Query: 420 LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 478
L + V D I ++ EL N + V + L + + +DREE+ TY
Sbjct: 192 LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 248
Query: 479 FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
+ DG Q S I+ + V D NDN P F E +V + + G SV QL A DA
Sbjct: 249 MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 308
Query: 537 DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 592
D G N +I + LV A+ F +N TTGLITI ++ + L V A+D
Sbjct: 309 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 368
Query: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 647
R V + V N+ P + + + + +SE + + + + TD++ D
Sbjct: 369 AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 424
Query: 648 ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 703
+T ++ P R+ + +L LD EST Y + + A+D G+P +A +
Sbjct: 425 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 484
Query: 704 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 761
I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y LG +
Sbjct: 485 FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 543
Query: 762 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 820
F + + T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT
Sbjct: 544 EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 603
Query: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 880
++ Y V ENLP T+ I D D G N + + + F + TG + S
Sbjct: 604 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 663
Query: 881 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 937
D E ++ S TF V+A D A VT+ V D+ND PVF Y +V P
Sbjct: 664 DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 719
Query: 938 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
GT + V A D D G+ A VRY + +F +++++G + +
Sbjct: 720 STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 774
Query: 998 PTTIFKLVVVAFDDGEP 1014
+ +++V A D G+P
Sbjct: 775 DLGLHRVLVKANDLGQP 791
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 493 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 155 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 213
Query: 553 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 214 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 271
Query: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 659
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 272 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 330
Query: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 718
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 331 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 389
Query: 719 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 764
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 390 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 449
Query: 765 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 824
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 450 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 503
Query: 825 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 883
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 504 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 563
Query: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 941
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 564 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 617
Query: 942 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 618 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 670
Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1054
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 671 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 730
Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1112
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 731 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 790
Query: 1113 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
VV+ NL V A + E+ ++ PV
Sbjct: 791 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 826
Score = 172 bits (436), Expect = 2e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 624 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 677
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 65 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 124
Query: 678 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 125 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 183
Query: 731 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 781
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 184 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 243
Query: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 244 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 303
Query: 842 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 304 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 359
Query: 897 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 950
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 360 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 417
Query: 951 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 418 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 470
Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1063
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 471 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 529
Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 530 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 581
Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 582 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 641
Query: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1243
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 642 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 696
Query: 1244 NQLDMQVIVSNVPP 1257
+ D + + VPP
Sbjct: 697 DVNDNKPVFI-VPP 709
Score = 168 bits (426), Expect = 4e-41
Identities = 188/769 (24%), Positives = 328/769 (42%), Gaps = 82/769 (10%)
Query: 98 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 118 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 172
Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 210
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 173 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 229
Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 230 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 281
Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
+ + +IPE N + T Q D +I + I +S
Sbjct: 282 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 324
Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 390
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 325 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 382
Query: 391 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYT 449
P + YI+ +S+++ L + + ++ + DKD + D+
Sbjct: 383 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHE 435
Query: 450 SVFTVTQTGITRY-LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNT 506
F + ++ L +D E + Y + A D + ++ ++ I+V D NDN
Sbjct: 436 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 495
Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 566
P F + V + + PG +++++A DAD G N EI Y + A +F +++ TG++T
Sbjct: 496 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLT 555
Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
+ ++ Y T+ A DN P N TV++ ++ N+ SP F Y +
Sbjct: 556 VVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVP 612
Query: 627 EAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYI 685
E + R G V L GD+ + D F + TG++ + DRE + Y
Sbjct: 613 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 672
Query: 686 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKA 741
+ A D GR +S+A V I V DVNDN PVF PY L + V QV A
Sbjct: 673 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 732
Query: 742 TDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHP 798
D D G+N +V YS+ GN +LF I G+I K + TD +H
Sbjct: 733 VDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VTDLGLH- 779
Query: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 847
+ +K D+ +F+ + V E++ T I ++ K ++
Sbjct: 780 -----RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 823
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 198 bits (504), Expect = 3e-50
Identities = 221/797 (27%), Positives = 343/797 (43%), Gaps = 57/797 (7%)
Query: 245 RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PII 299
R TT +L G + + L CV+ + + T + IPE ++LN +I
Sbjct: 14 RVNTTNCHKCLLSGTYIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLI 73
Query: 300 VTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQ 359
+ Q + + D P L+ ED F R L + RD H
Sbjct: 74 PNKSLTTTMQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHC 127
Query: 360 KFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLN 419
+++ + D L L I D N+ +P F I S P + I+
Sbjct: 128 FYEVEVAILPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYT 180
Query: 420 LTSPLRIVALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYT 478
L + V D I ++ EL N + V + L + + +DREE+ TY
Sbjct: 181 LPAA---VDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYV 237
Query: 479 FSITAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
+ DG Q S I+ + V D NDN P F E +V + + G SV QL A DA
Sbjct: 238 MKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDA 297
Query: 537 DEGSNGEITYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA 592
D G N +I + LV A+ F +N TTGLITI ++ + L V A+D
Sbjct: 298 DIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMP 357
Query: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS 647
R V + V N+ P + + + + +SE + + + + TD++ D
Sbjct: 358 AR----AMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADH 413
Query: 648 ---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATV 703
+T ++ P R+ + +L LD EST Y + + A+D G+P +A +
Sbjct: 414 NGRVTCFTDHEIPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAML 473
Query: 704 NIVVTDVNDNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNN 761
I V D NDNAPVF +S+ E + + +V ATD D+G N +++Y LG +
Sbjct: 474 FIKVKDENDNAPVFTQSFV-TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPP 532
Query: 762 LFRITSNGSIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFT 820
F + + T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT
Sbjct: 533 EFSLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFT 592
Query: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSL 880
++ Y V ENLP T+ I D D G N + + + F + TG + S
Sbjct: 593 HNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISF 652
Query: 881 DYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYK---GMVAP 937
D E ++ S TF V+A D A VT+ V D+ND PVF Y +V P
Sbjct: 653 DRE----KQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLP 708
Query: 938 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 997
GT + V A D D G+ A VRY + +F +++++G + +
Sbjct: 709 STNPGTVVFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVT 763
Query: 998 PTTIFKLVVVAFDDGEP 1014
+ +++V A D G+P
Sbjct: 764 DLGLHRVLVKANDLGQP 780
Score = 187 bits (474), Expect = 1e-46
Identities = 193/696 (27%), Positives = 301/696 (43%), Gaps = 69/696 (9%)
Query: 493 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 144 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 202
Query: 553 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 203 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 260
Query: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 659
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 261 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 319
Query: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 718
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 320 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 378
Query: 719 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 764
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 379 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 438
Query: 765 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 824
+ + A L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 439 LEN------AAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 492
Query: 825 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 883
TV + EN G ++++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 493 TVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLTVVKKLDRE 552
Query: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 941
+E F + A D +PP + VTV V D ND PVF+ YK V + +
Sbjct: 553 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPR 606
Query: 942 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 607 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 659
Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGE------IPRFTQE-EYRPPPVSELATKGTM 1054
+ V A D G SSSA V I V+ + +P + E P + +
Sbjct: 660 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQV 719
Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1112
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 720 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 779
Query: 1113 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
VV+ NL V A + E+ ++ PV
Sbjct: 780 PDSLFSVVIVNLFVNESVTNATLINELVRKSIEAPV 815
Score = 172 bits (436), Expect = 2e-42
Identities = 181/674 (26%), Positives = 291/674 (43%), Gaps = 69/674 (10%)
Query: 624 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 677
EI E + +G +L +L + S+T ++ GD + +T I T G +D
Sbjct: 54 EIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 113
Query: 678 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 114 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 172
Query: 731 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 781
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 173 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 232
Query: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 233 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 292
Query: 842 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 293 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 348
Query: 897 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 950
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 349 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 406
Query: 951 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
+DAD G + + P ++ F +E + L+ E T + + ++A
Sbjct: 407 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLENAA-------YLDYESTKEYAIKLLA 459
Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1063
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 460 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLMKVSATDADSGP 518
Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 519 NAEINY-LLGPDAPPEFSLDRRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 570
Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 571 LTSNVTVFVSIIDQNDNSPVFTHNEYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 630
Query: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1243
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 631 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 685
Query: 1244 NQLDMQVIVSNVPP 1257
+ D + + VPP
Sbjct: 686 DVNDNKPVFI-VPP 698
Score = 168 bits (426), Expect = 4e-41
Identities = 188/769 (24%), Positives = 328/769 (42%), Gaps = 82/769 (10%)
Query: 98 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 107 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 161
Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 210
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 162 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 218
Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 219 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 270
Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
+ + +IPE N + T Q D +I + I +S
Sbjct: 271 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 313
Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 390
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 314 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 371
Query: 391 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDTKDPELHLFLNDYT 449
P + YI+ +S+++ L + + ++ + DKD + D+
Sbjct: 372 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTC---FTDHE 424
Query: 450 SVFTVTQTGITRY-LTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMDANDNT 506
F + ++ L +D E + Y + A D + ++ ++ I+V D NDN
Sbjct: 425 IPFRLRPVFSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNA 484
Query: 507 PTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLIT 566
P F + V + + PG +++++A DAD G N EI Y + A +F +++ TG++T
Sbjct: 485 PVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEFSLDRRTGMLT 544
Query: 567 IAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEIS 626
+ ++ Y T+ A DN P N TV++ ++ N+ SP F Y +
Sbjct: 545 VVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEYKFYVP 601
Query: 627 EAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYI 685
E + R G V L GD+ + D F + TG++ + DRE + Y
Sbjct: 602 ENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREKQESYT 661
Query: 686 LIITASD-GRPDGTSTATVNIVVTDVNDNAPVF--DPY-LPRNLSVVEEEANAFVGQVKA 741
+ A D GR +S+A V I V DVNDN PVF PY L + V QV A
Sbjct: 662 FYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGTVVFQVIA 721
Query: 742 TDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHP 798
D D G+N +V YS+ GN +LF I G+I K + TD +H
Sbjct: 722 VDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VTDLGLH- 768
Query: 799 RHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 847
+ +K D+ +F+ + V E++ T I ++ K ++
Sbjct: 769 -----RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 812
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 195 bits (495), Expect = 4e-49
Identities = 218/790 (27%), Positives = 343/790 (43%), Gaps = 59/790 (7%)
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PIIVTPPIQAI 307
+D+L G + + L CV+ + + T + +PE ++LN +I +
Sbjct: 1 MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA 60
Query: 308 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 367
Q + + D P L+ ED F R L + RD H +++ +
Sbjct: 61 MQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAI 114
Query: 368 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
D L L I D N+ +P F I S P + I+ L + V
Sbjct: 115 LPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYTLPAA---V 164
Query: 428 ALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 486
D I ++ EL N + V + L + + +DREE+ TY + DG
Sbjct: 165 DPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDG 224
Query: 487 --VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Q S I+ + V D NDN P F E +V + + G SV QL A DAD G N +I
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 284
Query: 545 TYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
+ LV A+ F +N TTGLITI ++ + L V A+D R
Sbjct: 285 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPAR----AM 340
Query: 601 VYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS---ITYAI 652
V + V N+ P + + + + +SE + + + + TD++ D +T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 400
Query: 653 ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
++ P R+ + +L LD EST Y + + A+D G+P +A + I V D N
Sbjct: 401 DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 712 DNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNG 769
DNAPVF +S+ E + + +V A D D+G N +++Y LG + F +
Sbjct: 461 DNAPVFTQSFV-TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRT 519
Query: 770 SIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
+ T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT++ Y V
Sbjct: 520 GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYV 579
Query: 829 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 888
ENLP T+ I D D G N + + + F + TG + S D E +
Sbjct: 580 PENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDRE----K 635
Query: 889 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF----SKRIYKGMVAPDAVKGTP 944
+ S TF V+A D A VT+ V D+ND PVF S Y+ +V P GT
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTV 694
Query: 945 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
+ V A D D G+ A VRY + +F +++++G + + + ++
Sbjct: 695 VFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRV 749
Query: 1005 VVVAFDDGEP 1014
+V A D G+P
Sbjct: 750 LVKANDLGQP 759
Score = 185 bits (470), Expect = 3e-46
Identities = 193/696 (27%), Positives = 297/696 (42%), Gaps = 69/696 (9%)
Query: 493 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 181
Query: 553 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 239
Query: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 659
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 240 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 718
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 357
Query: 719 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 764
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 358 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 765 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 824
+ TA L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 418 LE------TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471
Query: 825 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 883
TV + EN G + ++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 941
+E F + A D +PP + VTV V D ND PVF+ Y V + +
Sbjct: 532 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPR 585
Query: 942 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 586 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 638
Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGEI-------PRFTQEEYRPPPVSELATKGTM 1054
+ V A D G SSSA V I V+ + P E P + +
Sbjct: 639 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQV 698
Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1112
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Query: 1113 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
VV+ NL V A + E+ ++ PV
Sbjct: 759 PDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPV 794
Score = 174 bits (442), Expect = 5e-43
Identities = 195/738 (26%), Positives = 311/738 (42%), Gaps = 80/738 (10%)
Query: 624 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 677
E+ E + +G +L +L + S+T A++ GD + +T I T G +D
Sbjct: 33 EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92
Query: 678 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 151
Query: 731 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 781
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211
Query: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 212 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271
Query: 842 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 272 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 327
Query: 897 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 950
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 328 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 385
Query: 951 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
+DAD G + + P ++ F +E T L+ E T + + ++A
Sbjct: 386 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKLLA 438
Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1063
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 439 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 498 NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 549
Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1243
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 610 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 1244 NQLDMQVIV----SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE-SIGARRHGDAF 1298
+ D + + SN LV T + + G V SI D F
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 1299 SLEDYT-------KCDLT 1309
+++ T KCD+T
Sbjct: 725 AIDQETGNITLMEKCDVT 742
Score = 163 bits (412), Expect = 1e-39
Identities = 191/775 (24%), Positives = 329/775 (42%), Gaps = 94/775 (12%)
Query: 98 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 86 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 140
Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 210
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 141 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 197
Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 198 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 249
Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
+ + +IPE N + T Q D +I + I +S
Sbjct: 250 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 292
Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 390
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 293 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 350
Query: 391 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDT------KDPELHL 443
P + YI+ +S+++ L + + ++ + DKD + D E+
Sbjct: 351 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPF 406
Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMD 501
L S + +T YL D E + Y + A D + ++ ++ I+V D
Sbjct: 407 RLRPVFSNQFLLET--AAYL------DYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKD 458
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT 561
NDN P F + V + + PG + +++A+DAD G N +I Y + A +F ++
Sbjct: 459 ENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCR 518
Query: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
TG++T+ ++ Y T+ A DN P N TV++ ++ N+ SP F Y
Sbjct: 519 TGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEY 575
Query: 622 SLEISEAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
+ + E + R G V L GD+ + D F + TG++ + DRE
Sbjct: 576 NFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK 635
Query: 681 TDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLS----VVEEEANAF 735
+ Y + A D GR +S+A V I V DVNDN PVF P N S +
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF-IVPPSNCSYELVLPSTNPGTV 694
Query: 736 VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVAT 792
V QV A D D G+N +V YS+ GN +LF I G+I K + T
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VT 742
Query: 793 DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 847
D +H + +K D+ +F+ + V E++ T I ++ K +
Sbjct: 743 DLGLH------RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 195 bits (495), Expect = 4e-49
Identities = 218/790 (27%), Positives = 343/790 (43%), Gaps = 59/790 (7%)
Query: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPEL----RTPEELN-PIIVTPPIQAI 307
+D+L G + + L CV+ + + T + +PE ++LN +I +
Sbjct: 1 MDLLSGTYIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTA 60
Query: 308 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 367
Q + + D P L+ ED F R L + RD H +++ +
Sbjct: 61 MQFKLVYKTGDVP------LIRIEEDTGEIFTTGARIDREKLCAGIPRDEHCFYEVEVAI 114
Query: 368 EQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIV 427
D L L I D N+ +P F I S P + I+ L + V
Sbjct: 115 LPDEIFRLVKIRFL---IEDINDNAPLFPAT----VINISIPENSAINSKYTLPAA---V 164
Query: 428 ALDKDIEDTKDPELHLFLNDY-TSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG 486
D I ++ EL N + V + L + + +DREE+ TY + DG
Sbjct: 165 DPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDG 224
Query: 487 --VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEI 544
Q S I+ + V D NDN P F E +V + + G SV QL A DAD G N +I
Sbjct: 225 GFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATDADIGENAKI 284
Query: 545 TYEI--LVG--AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 600
+ LV A+ F +N TTGLITI ++ + L V A+D R
Sbjct: 285 HFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLMPAR----AM 340
Query: 601 VYIEVLPPNNQSPPRFPQLMYS-----LEISEAMRVGAVLLNLQATDREGDS---ITYAI 652
V + V N+ P + + + + +SE + + + + TD++ D +T
Sbjct: 341 VLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFT 400
Query: 653 ENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVN 711
++ P R+ + +L LD EST Y + + A+D G+P +A + I V D N
Sbjct: 401 DHEIPFRLRPVFSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDEN 460
Query: 712 DNAPVFDPYLPRNLSVVEEEANAF-VGQVKATDPDAGINGQVHYSLG-NFNNLFRITSNG 769
DNAPVF +S+ E + + +V A D D+G N +++Y LG + F +
Sbjct: 461 DNAPVFTQSFV-TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRT 519
Query: 770 SIYTAVK-LNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLV 828
+ T VK L+RE D Y ++A D V P S +T+ + ++D +DNSPVFT++ Y V
Sbjct: 520 GMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYV 579
Query: 829 EENLPAGTTILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQ 888
ENLP T+ I D D G N + + + F + TG + S D E +
Sbjct: 580 PENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDRE----K 635
Query: 889 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF----SKRIYKGMVAPDAVKGTP 944
+ S TF V+A D A VT+ V D+ND PVF S Y+ +V P GT
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYE-LVLPSTNPGTV 694
Query: 945 ITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKL 1004
+ V A D D G+ A VRY + +F +++++G + + + ++
Sbjct: 695 VFQVIAVDND-TGMNA-EVRYSIVGGN---TRDLFAIDQETGNITLMEKCDVTDLGLHRV 749
Query: 1005 VVVAFDDGEP 1014
+V A D G+P
Sbjct: 750 LVKANDLGQP 759
Score = 185 bits (470), Expect = 3e-46
Identities = 193/696 (27%), Positives = 297/696 (42%), Gaps = 69/696 (9%)
Query: 493 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGA 552
V + + D NDN P FP ++ + + AVD D G NG YE L+ +
Sbjct: 123 VKIRFLIEDINDNAPLFPATVINISIPENSAINSKYTLPAAVDPDVGINGVQNYE-LIKS 181
Query: 553 QGDF---IINKTTG----LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEV 605
Q F +I G + + ++ TY + V+ D P +R+S + + V
Sbjct: 182 QNIFGLDVIETPEGDKMPQLIVQKELDREEKDTYVMKVKVEDGGFP--QRSSTAILQVSV 239
Query: 606 LPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIEN---GDPQR 659
N+ P F + + I E VG + L ATD E I ++ N +R
Sbjct: 240 TDTNDNHPV-FKETEIEVSIPENAPVGTSVTQLHATDADIGENAKIHFSFSNLVSNIARR 298
Query: 660 VFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD- 718
+F+L+ TTG++T+ + LDRE T + L++ ASDG + A V + VTDVNDN P D
Sbjct: 299 LFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM-PARAMVLVNVTDVNDNVPSIDI 357
Query: 719 PYL--PRNLSVVEEE---ANAFVGQVKATDPDAGINGQVHYSLGN---------FNNLFR 764
Y+ P N +VV E N + + TD DA NG+V + F+N F
Sbjct: 358 RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPFRLRPVFSNQFL 417
Query: 765 ITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTY 824
+ TA L+ E Y + ++A D P + + L IKV D +DN+PVFT S
Sbjct: 418 LE------TAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKDENDNAPVFTQSFV 471
Query: 825 TVLVEENLPAGTTILQIEAKDVDLGANVSYR-IRSPEVKHFFALHPFTGELSLLRSLDYE 883
TV + EN G + ++ A D D G N + P+ F+L TG L++++ LD E
Sbjct: 472 TVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCRTGMLTVVKKLDRE 531
Query: 884 AFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAPDAVK 941
+E F + A D +PP + VTV V D ND PVF+ Y V + +
Sbjct: 532 ----KEDKYLFTILAKD--NGVPPLTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPR 585
Query: 942 GTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTI 1001
+ + D D A + ++ F ++ +G + ++ + E
Sbjct: 586 HGTVGLITVTDPDYGDNSAVTLSILDENDDFT-------IDSQTGVIRPNISFDREKQES 638
Query: 1002 FKLVVVAFDDGEPVMSSSATVKILVLHPGEI-------PRFTQEEYRPPPVSELATKGTM 1054
+ V A D G SSSA V I V+ + P E P + +
Sbjct: 639 YTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQV 698
Query: 1055 VGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSL-- 1112
+ V + +N + YSIV GN D F I+ TG I + D + + V+A+ L
Sbjct: 699 IAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLVKANDLGQ 758
Query: 1113 -----EVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1143
VV+ NL V A + E+ ++ PV
Sbjct: 759 PDSLFSVVIVNLFVNESVTNATLINELVRKSTEAPV 794
Score = 174 bits (442), Expect = 5e-43
Identities = 195/738 (26%), Positives = 311/738 (42%), Gaps = 80/738 (10%)
Query: 624 EISEAMRVGAVLLNLQATDREGDSITYAIE------NGDPQRVFNLSETTGILTLGKALD 677
E+ E + +G +L +L + S+T A++ GD + +T I T G +D
Sbjct: 33 EMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVYKTGDVPLIRIEEDTGEIFTTGARID 92
Query: 678 REST------DRYILIITASDGRPDGT-STATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 730
RE D + PD + ++ D+NDNAP+F P N+S+ E
Sbjct: 93 REKLCAGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLF-PATVINISIPEN 151
Query: 731 EA-NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI----TSNGS----IYTAVKLNREV 781
A N+ A DPD GING +Y L N+F + T G + +L+RE
Sbjct: 152 SAINSKYTLPAAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREE 211
Query: 782 RDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQI 841
+D Y + V DG R ST L + V D +DN PVF + V + EN P GT++ Q+
Sbjct: 212 KDTYVMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQL 271
Query: 842 EAKDVDLGANVSYRIR-----SPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
A D D+G N S + F L+ TG +++ LD E P+ + LV
Sbjct: 272 HATDADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHK----LLV 327
Query: 897 EAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAV--KGTPITTVYA---- 950
A D G + P A V V V D+ND P R V V + P+ T A
Sbjct: 328 LASD--GGLMPARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITV 385
Query: 951 --EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 1008
+DAD G + + P ++ F +E T L+ E T + + ++A
Sbjct: 386 TDKDADHNGRVTCFTDHEIPFRLRPVFSNQFLLE-------TAAYLDYESTKEYAIKLLA 438
Query: 1009 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAI 1063
D G+P ++ SA + I V + P FTQ + + E + G + +SA +
Sbjct: 439 ADAGKPPLNQSAMLFIKVKDENDNAPVFTQS-FVTVSIPENNSPGIQLTKVSAMDADSGP 497
Query: 1064 NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1123
N I Y ++ + F ++ TG++ V LD E Y+ + A + VP
Sbjct: 498 NAKINY-LLGPDAPPEFSLDCRTGMLTVVKKLDREKEDKYLFTILAK-------DNGVPP 549
Query: 1124 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1183
++ V++ I D+N++ PVF Y V E+ +V + TD D G+ S + +
Sbjct: 550 LTSNVTVFVSIIDQNDNSPVFTHNEYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSI 609
Query: 1184 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1243
+ + + F +++ TG+I+ + F ++ + F V A D S A V ++VV
Sbjct: 610 L-----DENDDFTIDSQTGVIRPNISFDREKQESYTFYVKAEDGGRVSRSSSAKVTINVV 664
Query: 1244 NQLDMQVIV----SNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVE-SIGARRHGDAF 1298
+ D + + SN LV T + + G V SI D F
Sbjct: 665 DVNDNKPVFIVPPSNCSYELVLPSTNPGTVVFQVIAVDNDTGMNAEVRYSIVGGNTRDLF 724
Query: 1299 SLEDYT-------KCDLT 1309
+++ T KCD+T
Sbjct: 725 AIDQETGNITLMEKCDVT 742
Score = 163 bits (412), Expect = 1e-39
Identities = 191/775 (24%), Positives = 329/775 (42%), Gaps = 94/775 (12%)
Query: 98 STGRVLDRDP-----PMNIHSIV-VQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHES 151
+TG +DR+ P + H V+V + ++ ++ ++R ++ D NDN+P F
Sbjct: 86 TTGARIDREKLCAGIPRDEHCFYEVEVAILPDEIFRLV--KIRFLIEDINDNAPLFP--- 140
Query: 152 YYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL-ML 210
+N P + I + ++ A D D G NG Y + + D E P
Sbjct: 141 -ATVINISIPENSAINSKYTLP-AAVDPDVGINGVQNYEL-IKSQNIFGLDVIETPEGDK 197
Query: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
++++K L+ E+K Y + ++ D +R++T L V V D +D P+F
Sbjct: 198 MPQLIVQKELDREEKDTYVMKVKVEDGG---FPQRSSTAILQVSVTDTNDNHPVF----- 249
Query: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
+ + +IPE N + T Q D +I + I +S
Sbjct: 250 -------KETEIEVSIPE-------NAPVGTSVTQLHATDADI---GENAKIHFSFSNLV 292
Query: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENN 390
R FH++ T +++ EP++R+ L++ A +G +PA A + + + D N+
Sbjct: 293 SNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLA--SDGGLMPARAMVLVNVTDVND 350
Query: 391 QSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL-DKDIEDT------KDPELHL 443
P + YI+ +S+++ L + + ++ + DKD + D E+
Sbjct: 351 NVPSIDI----RYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGRVTCFTDHEIPF 406
Query: 444 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--SEPVIVNIQVMD 501
L S + +T YL D E + Y + A D + ++ ++ I+V D
Sbjct: 407 RLRPVFSNQFLLET--AAYL------DYESTKEYAIKLLAADAGKPPLNQSAMLFIKVKD 458
Query: 502 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKT 561
NDN P F + V + + PG + +++A+DAD G N +I Y + A +F ++
Sbjct: 459 ENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEFSLDCR 518
Query: 562 TGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMY 621
TG++T+ ++ Y T+ A DN P N TV++ ++ N+ SP F Y
Sbjct: 519 TGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSN--VTVFVSIIDQNDNSPV-FTHNEY 575
Query: 622 SLEISEAM-RVGAVLLNLQATDREGDSITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
+ + E + R G V L GD+ + D F + TG++ + DRE
Sbjct: 576 NFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDREK 635
Query: 681 TDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLS----VVEEEANAF 735
+ Y + A D GR +S+A V I V DVNDN PVF P N S +
Sbjct: 636 QESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVF-IVPPSNCSYELVLPSTNPGTV 694
Query: 736 VGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVAT 792
V QV A D D G+N +V YS+ GN +LF I G+I K + T
Sbjct: 695 VFQVIAVDNDTGMNAEVRYSIVGGNTRDLFAIDQETGNITLMEKCD------------VT 742
Query: 793 DGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 847
D +H + +K D+ +F+ + V E++ T I ++ K +
Sbjct: 743 DLGLH------RVLVKANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 68,002,902
Number of Sequences: 37866
Number of extensions: 3416021
Number of successful extensions: 45071
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 490
Number of HSP's successfully gapped in prelim test: 177
Number of HSP's that attempted gapping in prelim test: 24656
Number of HSP's gapped (non-prelim): 7767
length of query: 1677
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1561
effective length of database: 13,855,062
effective search space: 21627751782
effective search space used: 21627751782
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.