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Search of human proteins with 217272802
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|217272802 hyaluronan-mediated motility receptor isoform a
[Homo sapiens]
(725 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 1389 0.0
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 1382 0.0
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 1348 0.0
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 1211 0.0
gi|9910266 kinesin family member 15 [Homo sapiens] 133 5e-31
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 127 4e-29
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 125 1e-28
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 124 3e-28
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 123 7e-28
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 122 9e-28
gi|156104908 myosin heavy chain 6 [Homo sapiens] 122 2e-27
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 120 3e-27
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 119 1e-26
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 117 4e-26
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 117 5e-26
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 117 5e-26
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 116 6e-26
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 116 8e-26
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 116 8e-26
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 116 8e-26
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 115 1e-25
gi|21735548 centrosomal protein 2 [Homo sapiens] 114 2e-25
gi|32698688 citron [Homo sapiens] 114 2e-25
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 114 2e-25
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 114 3e-25
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 114 4e-25
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 113 5e-25
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 113 5e-25
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 113 5e-25
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 113 5e-25
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 1389 bits (3595), Expect = 0.0
Identities = 725/725 (100%), Positives = 725/725 (100%)
Query: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
Query: 61 TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 120
TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL
Sbjct: 61 TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 120
Query: 121 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 180
NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET
Sbjct: 121 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 180
Query: 181 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 240
KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE
Sbjct: 181 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 240
Query: 241 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 300
ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE
Sbjct: 241 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 300
Query: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK
Sbjct: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK
Sbjct: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
Query: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS
Sbjct: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
Query: 481 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD
Sbjct: 481 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
Query: 541 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600
LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA
Sbjct: 541 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600
Query: 601 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660
FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR
Sbjct: 601 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660
Query: 661 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 720
CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC
Sbjct: 661 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 720
Query: 721 QESWK 725
QESWK
Sbjct: 721 QESWK 725
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 1382 bits (3578), Expect = 0.0
Identities = 724/725 (99%), Positives = 724/725 (99%), Gaps = 1/725 (0%)
Query: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
Query: 61 TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 120
TLPASARKVKSSESK ESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL
Sbjct: 61 TLPASARKVKSSESK-ESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 119
Query: 121 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 180
NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET
Sbjct: 120 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 179
Query: 181 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 240
KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE
Sbjct: 180 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 239
Query: 241 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 300
ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE
Sbjct: 240 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 299
Query: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK
Sbjct: 300 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 359
Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK
Sbjct: 360 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 419
Query: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS
Sbjct: 420 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 479
Query: 481 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD
Sbjct: 480 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 539
Query: 541 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600
LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA
Sbjct: 540 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 599
Query: 601 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660
FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR
Sbjct: 600 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 659
Query: 661 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 720
CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC
Sbjct: 660 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 719
Query: 721 QESWK 725
QESWK
Sbjct: 720 QESWK 724
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 1348 bits (3489), Expect = 0.0
Identities = 709/725 (97%), Positives = 709/725 (97%), Gaps = 16/725 (2%)
Query: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT
Sbjct: 1 MSFPKAPLKRFNDPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT 60
Query: 61 TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL 120
TLPASARKVKSSESK IRVLLQERGAQDRRIQDLETELEKMEARL
Sbjct: 61 TLPASARKVKSSESK----------------IRVLLQERGAQDRRIQDLETELEKMEARL 104
Query: 121 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 180
NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET
Sbjct: 105 NAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET 164
Query: 181 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 240
KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE
Sbjct: 165 KMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE 224
Query: 241 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 300
ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE
Sbjct: 225 ISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE 284
Query: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK
Sbjct: 285 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 344
Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK
Sbjct: 345 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 404
Query: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS
Sbjct: 405 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 464
Query: 481 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD
Sbjct: 465 LQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 524
Query: 541 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600
LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA
Sbjct: 525 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 584
Query: 601 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660
FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR
Sbjct: 585 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 644
Query: 661 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 720
CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC
Sbjct: 645 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMEC 704
Query: 721 QESWK 725
QESWK
Sbjct: 705 QESWK 709
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 1211 bits (3132), Expect = 0.0
Identities = 634/634 (100%), Positives = 634/634 (100%)
Query: 92 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 151
IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL
Sbjct: 5 IRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELL 64
Query: 152 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 211
KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA
Sbjct: 65 KSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIA 124
Query: 212 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 271
QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS
Sbjct: 125 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 184
Query: 272 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 331
LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ
Sbjct: 185 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 244
Query: 332 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 391
EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ
Sbjct: 245 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 304
Query: 392 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 451
KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ
Sbjct: 305 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 364
Query: 452 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 511
SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR
Sbjct: 365 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 424
Query: 512 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 571
MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA
Sbjct: 425 MLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTA 484
Query: 572 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 631
ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG
Sbjct: 485 ELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 544
Query: 632 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 691
HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA
Sbjct: 545 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKA 604
Query: 692 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 725
FHHESKENFALKTPLKEGNTNCYRAPMECQESWK
Sbjct: 605 FHHESKENFALKTPLKEGNTNCYRAPMECQESWK 638
Score = 64.7 bits (156), Expect = 3e-10
Identities = 103/467 (22%), Positives = 191/467 (40%), Gaps = 99/467 (21%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQER 99
K Q +++KE N N + + L A + +K ILE++ R LQ++
Sbjct: 206 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF-------------ILEQQEREKLQQK 252
Query: 100 GAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENG 159
Q L + E L+++L +K EK L E E LK
Sbjct: 253 ELQ-------IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE-----EELKQTLD--- 297
Query: 160 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 219
EL KL+ K E R + +E + + + + E+ +GK A+LE +
Sbjct: 298 ----------ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAA 347
Query: 220 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 279
+ + + + + +++ +E+++ Q E YK A E+LK +N SL+E
Sbjct: 348 HTQATLLLQEKYDSMVQSLEDVTA---QFESYKALTASEIEDLKLEN-------SSLQEK 397
Query: 280 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 339
K ED+ + E +++V + +L+ Q + L++
Sbjct: 398 AAKAGKNAEDVQHQILATESSNQEYV-------------------RMLLDLQTKSALKET 438
Query: 340 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399
E+ KE++ S QK+ Q ++ +++ F ++L+ DE + +KE L
Sbjct: 439 EI---------KEITVSFLQKITDLQNQLKQQEEDFRKQLE---DEEGRKAEKENTTAEL 486
Query: 400 VKQ------LEEEAKSRAEELKL-LEEKLKGKEAELEKSSAAHTQ--------ATLL--- 441
++ L EE ++ + +L L+ K+A L + AA Q A LL
Sbjct: 487 TEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ 546
Query: 442 -LQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAK 487
L++K +V+ L+D +Q +S + ++ K + LQE+ K
Sbjct: 547 NLKQKIKHVVK-LKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNK 592
Score = 46.2 bits (108), Expect = 1e-04
Identities = 73/357 (20%), Positives = 152/357 (42%), Gaps = 46/357 (12%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
QK F+++ ++NL ++ K++ E + E + +K LE+E + +E
Sbjct: 272 QKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAE-----RLVKQLEEEAKSRAEE 326
Query: 99 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
+ +++ E ELEK +AA + T L L+++ + ++ E + ++F
Sbjct: 327 LKLLEEKLKGKEAELEKS----SAAHTQATLL------LQEKYDSMVQSLEDVTAQFE-- 374
Query: 159 GNQKNLRILSLELMKLRNKRETKMRGMMAKQ-EGMEMKLQVTQRSLEESQGKIAQLEGKL 217
+ K L +E +KL N + K E ++ ++ T+ S +E + L+
Sbjct: 375 -SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQ--- 430
Query: 218 VSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI-----------AQLEENLKEKN 266
K + E E + ++++I+ +Q+++ + D A+ E E
Sbjct: 431 ---TKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELT 487
Query: 267 DEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF 326
+EI + EE L + + ++ E EK+ +N + E LN ++++ K
Sbjct: 488 EEINKWRLLYEE----LYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN-KIRDSYAKL 542
Query: 327 ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 383
+ Q L+QK + L + +L S + + C ++ E L +EEL + L
Sbjct: 543 LGHQ----NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKL-QEELNKVL 594
>gi|9910266 kinesin family member 15 [Homo sapiens]
Length = 1388
Score = 133 bits (335), Expect = 5e-31
Identities = 157/680 (23%), Positives = 305/680 (44%), Gaps = 80/680 (11%)
Query: 45 KQQKESKQNLNVDKDTTLPASARKVKSSES---KKESQKNDKDLKILEKEIRVLLQERGA 101
++ K K +VDK +++ SSE K+ ++ L +LEK+++ +
Sbjct: 736 EEHKNLKLQQHVDKLEHHSTQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDF 795
Query: 102 QDRRIQDLETELEKMEARLNAALREKTS-----------LSANNATLEKQLIELTRTNE- 149
+ DL L + L++ E +S LS + ++ QL L NE
Sbjct: 796 LKSEVHDLRVVLHSADKELSSVKLEYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEK 855
Query: 150 LLKSKFSENGNQKNLRILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
LL+SK + NL+ E+MK ++ ++ + E ++ L LE +
Sbjct: 856 LLESKACLQDSYDNLQ----EIMKFEIDQLSRNLQNFKKENETLKSDLNNLMELLEAEKE 911
Query: 209 KIAQLEGKLVSIEKEKIDEKSETEKLLEYI-EEISCASDQVEKYKLDIAQLEENLKEKND 267
+ +L + E++K + E K+LE + +E + + E+ + +LEE+L
Sbjct: 912 RNNKLS---LQFEEDKENSSKEILKVLEAVRQEKQKETAKCEQQMAKVQKLEESLLATEK 968
Query: 268 EILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF- 326
I SL++S + + K V DL + Q E V E + L E++++ K+
Sbjct: 969 VISSLEKSRDSD----KKVVADLMNQIQ----ELRTSVCEKTETIDTLKQELKDINCKYN 1020
Query: 327 -ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDE 385
L +E ++ K+ ++D L +L +L ++ S E++ E+++ E+L ++
Sbjct: 1021 SALVDREESRVLIKKQEVDIL-----DLKETLRLRILS--EDI--ERDMLCEDLAHATEQ 1071
Query: 386 LDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEK 445
L+ L + ++ L++ +EE + ++ L+ KL K+ E+E+ + L+
Sbjct: 1072 LNMLTEASKKHSGLLQSAQEELTKKEALIQELQHKLNQKKEEVEQKKNEYNFKMRQLEHV 1131
Query: 446 YDSMVQSLED--VTAQFESYKA----LTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
DS + + F+++ A EIED + +SL+ K ++ E +I
Sbjct: 1132 MDSAAEDPQSPKTPPHFQTHLAKLLETQEQEIEDGRASKTSLEHLVTKLNEDREVKNAEI 1191
Query: 500 LATESSNQEYVRMLLDLQT---KSALKETEIKEITVSFLQKITDLQN-----QLKQQEED 551
L + +E + L+ Q K+ L + ++ +I QK QN QLK ++E+
Sbjct: 1192 LRMKEQLREMENLRLESQQLIEKNWLLQGQLDDIK---RQKENSDQNHPDNQQLKNEQEE 1248
Query: 552 FRKQ-----------------LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPF 594
K+ LE+ + KE +T+E+ + + L + + + +
Sbjct: 1249 SIKERLAKSKIVEEMLKMKADLEEVQSALYNKEMECLRMTDEVERTQTLESKAFQEKEQL 1308
Query: 595 QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKS 654
+ +L+ E++ E ++Q+ + + KL+GHQNL QKI++VV+LK EN +L
Sbjct: 1309 RSKLEEMYEERERTSQEMEMLRKQVECLAEENGKLVGHQNLHQKIQYVVRLKKENVRLAE 1368
Query: 655 EVSKLRCQ---LAKKKQSET 671
E KLR + L +KK+SE+
Sbjct: 1369 ETEKLRAENVFLKEKKRSES 1388
Score = 78.6 bits (192), Expect = 2e-14
Identities = 162/747 (21%), Positives = 321/747 (42%), Gaps = 121/747 (16%)
Query: 38 FQKSQRFKQQKESKQNLNVDKDTTLP-ASARKVKSSESKKESQKNDKD----LKILEKEI 92
FQ++ F ++ E ++ ++K T L + +K K +S K K +D L+ L KE
Sbjct: 418 FQEAMLFFKKSEQEKKSLIEKVTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKES 477
Query: 93 RV-LLQERGAQDRRIQDLETELEKMEARL------------NAALREKT----------- 128
R L E QDR + +L E++ + ++ N +LRE+
Sbjct: 478 RGGFLPEE--QDRLLSELRNEIQTLREQIEHHPRVAKYAMENHSLREENRRLRLLEPVKR 535
Query: 129 --SLSANN-ATLEKQLIELTRTNELLKSK--FSENGNQKNLRILSLELMKLRNKR-ETKM 182
+ A A LEK E++ + K++ FS ++ + E +K + + +T++
Sbjct: 536 AQEMDAQTIAKLEKAFSEISGMEKSDKNQQGFSPKAQKEPCLFANTEKLKAQLLQIQTEL 595
Query: 183 RGMMAKQEGMEMKLQVTQRSLE-ESQGKIAQ-----LEGKLVSIEKEKIDEKSETEKLLE 236
+KQE E K +R LE ES+ + Q LE L + + K E S+ K+
Sbjct: 596 NN--SKQEYEEFKELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNKI-- 651
Query: 237 YIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQL 296
+ E + + + Y+L + + + E+ S +N IL + + V ++
Sbjct: 652 HAETLKIITTPTKAYQLH----SRPVPKLSPEMGSFGSLYTQNSSILDNDILNEPVPPEM 707
Query: 297 LEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSS 356
E+ E R E ++A L+ K E+ + KLQQ +++ Q +EL SS
Sbjct: 708 NEQAFEAISEELRTVQEQMSA----LQAKLDEEEHKNLKLQQHVDKLEHHSTQMQELFSS 763
Query: 357 LHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 416
QEE++ + N+ E++L++T + D L+ + ++ ++E S +KL
Sbjct: 764 ERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSS----VKL 819
Query: 417 LEEKLK-GKEAELEKSSAAHTQATL-----------------LLQEKYDSMVQSLEDVTA 458
K +E E K S H L LQ+ YD++ + ++
Sbjct: 820 EYSSFKTNQEKEFNKLSERHMHVQLQLDNLRLENEKLLESKACLQDSYDNLQEIMKFEID 879
Query: 459 QFESYKALTASEIEDLKLENSSLQE--KAAKAGKNAEDVQHQILATESSNQEYVRML--- 513
Q E E LK + ++L E +A K N +Q + E+S++E +++L
Sbjct: 880 QLSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFE-EDKENSSKEILKVLEAV 938
Query: 514 -LDLQTKSALKETEIKEI------------TVSFLQK--------ITDLQNQLKQQEEDF 552
+ Q ++A E ++ ++ +S L+K + DL NQ+++
Sbjct: 939 RQEKQKETAKCEQQMAKVQKLEESLLATEKVISSLEKSRDSDKKVVADLMNQIQELRTSV 998
Query: 553 RKQLEDEEGRKAEKENTTAELTEEI---NKWRLLYE----ELYNKTKPFQLQLDAFEVEK 605
++ E + K E ++ + + + R+L + ++ + + +L++ + ++E+
Sbjct: 999 CEKTETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILDLKETLRLRILSEDIER 1058
Query: 606 QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAK 665
L + A EQLN + ++ K H L Q ++E ++ ++ + +L+ +L +
Sbjct: 1059 DMLCEDLAHATEQLNMLTEASKK---HSGLLQ------SAQEELTKKEALIQELQHKLNQ 1109
Query: 666 KKQSETKLQEELN-KVLGIKHFDPSKA 691
KK+ + + E N K+ ++H S A
Sbjct: 1110 KKEEVEQKKNEYNFKMRQLEHVMDSAA 1136
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 127 bits (319), Expect = 4e-29
Identities = 143/684 (20%), Positives = 308/684 (45%), Gaps = 87/684 (12%)
Query: 68 KVKSSESKKESQKNDKDLKILEKEIR--VLLQERGA----QDRRIQDLETELEKMEARLN 121
+++ +E++K + D + ++++ I LL E+ A + + +++L + E + RL+
Sbjct: 234 ELELAENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLH 293
Query: 122 AALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETK 181
L++ L + +++++ +L+ N L K E + +L+ L L +L +
Sbjct: 294 ETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFAS--HLQQLQDALNELTEEHSKA 351
Query: 182 MRGMMAKQEGMEMKLQVT---QRSLEES----QGKIAQLEGKLVSIEKEKIDEKSETE-- 232
+ + KQ +E +L ++ LEE QGK++QLE L ++ EK E
Sbjct: 352 TQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGD 411
Query: 233 --KLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL 290
+L +E + + + + + LE ++ ++L+ + EE LS + DL
Sbjct: 412 VLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDL 471
Query: 291 NVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI---------------LEQQEREK 335
L + KE+ ++ H L A++ +L + L+QQ +EK
Sbjct: 472 QSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEK 531
Query: 336 -------LQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
LQQ+E L Q ++LSSSL QK +E K++ ++ +Q ++
Sbjct: 532 QAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEE 591
Query: 389 LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQA---TLLLQEK 445
+ + + +KQLE K +A +L++L+++L+ + + + TQA L K
Sbjct: 592 REASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRK 651
Query: 446 YDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAED---VQHQILA- 501
+ + +E TA+ E ++A +++ +L+L+ S Q+KA + + A++ +Q Q+ A
Sbjct: 652 VEELQACVE--TARQEQHEA--QAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQAL 707
Query: 502 ------TESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE------ 549
T+ S +E R D + +E+K T S +++ + +L+++
Sbjct: 708 KESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGL 767
Query: 550 ---------------EDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPF 594
E R++L + + E+ +L +E+ WR YE+ + +
Sbjct: 768 EARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQY 827
Query: 595 QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKS 654
F+ + L E A+++L + ++ A + H L+ + + ++E ++L +
Sbjct: 828 GAM---FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQ-----ISRQQNELAELHA 879
Query: 655 EVSKLRCQLAKKKQSETKLQEELN 678
+++ Q+ +K+ KL ++L+
Sbjct: 880 NLARALQQVQEKEVRAQKLADDLS 903
Score = 99.8 bits (247), Expect = 8e-21
Identities = 154/679 (22%), Positives = 281/679 (41%), Gaps = 95/679 (13%)
Query: 97 QERGAQDRRIQDLETELEKMEA--RLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 154
+ERG Q+R + L E + +A L A R + + NA L +Q +E E L
Sbjct: 997 EERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNA-LNEQRVEFATLQEALAHA 1055
Query: 155 FSENGNQKNLRILSLELMKLRNKRETKMRGMMA-KQEGMEMKLQVTQRSLEESQGKIAQL 213
+E + EL KLR +++ + +Q ++K Q+ ++ E + G AQ
Sbjct: 1056 LTEKEGKDQ------ELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQS 1109
Query: 214 EG---------KLVSIEKEKIDEKSETEKLLEYIEEI--SCASDQVEKYKLDIA--QLEE 260
E KL ++ E + + +K E + + S +++ + + D A L+
Sbjct: 1110 EAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQG 1169
Query: 261 NLKEKNDEI---LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA 317
L+EK E+ S S + + +V+D + E E + V R R+ E N+
Sbjct: 1170 QLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKA----EDEWKAQVARGRQEAERKNS 1225
Query: 318 EMQNLKQKF-ILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE 376
+ +L+++ IL +Q EK + + ++ L+ E E S L ++L Q E
Sbjct: 1226 LISSLEEEVSILNRQVLEK-EGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAA 1284
Query: 377 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------ELKLLEEKLKGKEAELE 429
E +E+ L+++ E+ + L +E S+AE ELK +EK KE L
Sbjct: 1285 ERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALS 1344
Query: 430 KSSAAHTQATLLLQEKYDS--MVQSLEDVTAQFE---------SYKALTASEIEDLKLEN 478
HT L+ E + + Q L+ A E S +A E L+ +
Sbjct: 1345 TLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQR 1404
Query: 479 S-----SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSA------------ 521
L++K A+ + A+ Q+ A ++S E + ML A
Sbjct: 1405 ELGELIPLRQKVAEQERTAQ----QLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANL 1460
Query: 522 ---LKETEIKEITVSFLQKI----TDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELT 574
E E+ + ++Q++ D + +L + + + + + E A+ E ++
Sbjct: 1461 GRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVL 1520
Query: 575 EEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS-YAKLLGHQ 633
EE R ++E K QL+ F+ E+ +E K+ DS A + Q
Sbjct: 1521 EE----RQRFQEERQKLTAQVEQLEVFQREQTK------QVEELSKKLADSDQASKVQQQ 1570
Query: 634 NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS--ETKLQEELNKVLGIKHFDPSKA 691
LK + + E +L++++++L+ QL++K+Q+ KLQ E K H+D K
Sbjct: 1571 KLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKT----HYDAKKQ 1626
Query: 692 FHHESKENFALKTPLKEGN 710
+ E +E L++ N
Sbjct: 1627 QNQELQEQLRSLEQLQKEN 1645
Score = 97.1 bits (240), Expect = 5e-20
Identities = 126/658 (19%), Positives = 274/658 (41%), Gaps = 62/658 (9%)
Query: 23 AYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDT---TLPAS----ARKVKSSESK 75
A +K LE L+ V K Q K++KE + T P A + + S+ +
Sbjct: 1074 AAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE 1133
Query: 76 KESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNA 135
++ QK + LE+ + R +D ++ L+ +LE+ L + S A
Sbjct: 1134 QQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELA 1193
Query: 136 TLEKQLIELTRTNELLKSKFS---ENGNQKNLRILSLE----------LMKLRNKRETKM 182
++ + ++ + K++ + + +KN I SLE L K +E K
Sbjct: 1194 AFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELK- 1252
Query: 183 RGMMA---KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLL--EY 237
R +MA K + +E +L++ Q + + A+ L E + + E++E +++
Sbjct: 1253 RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALRE-EVQSLREEAEKQRVASENL 1311
Query: 238 IEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLL 297
+E++ +++ E+ ++ +E +K + +L+ ++S+ + ++ CQ L
Sbjct: 1312 RQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHL-CQQL 1370
Query: 298 EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQE-------REKLQQKELQIDSLLQQE 350
+ E+ R+RE E L+ + + Q+E R+K+ ++E L ++
Sbjct: 1371 QAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEK 1430
Query: 351 KELSSSL------HQKLCSFQEEMVKEKNLFEEELKQTLDE-----LDKLQQKEEQAERL 399
+ L H L + + NL + L+ LD+ + +L AE
Sbjct: 1431 ASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETR 1490
Query: 400 VKQLEEEAKSRAEELKLLEEKLKGKEA----------ELEKSSAAHTQATLLLQEKYDSM 449
+ +++ EA+S A EL+++ K +G + E + A + + Q +
Sbjct: 1491 LAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQLEVFQREQTKQ 1550
Query: 450 VQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEY 509
V+ L A + + +++ ++ + Q++A + ++Q Q+ E + + Y
Sbjct: 1551 VEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHY 1610
Query: 510 VRMLLDLQTKSALKETEIKEI--TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE 567
+ +T K+ + +E+ + L+++ +L+ + E +L+ + E E
Sbjct: 1611 KLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAE 1670
Query: 568 NTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDS 625
T LT ++ R L ++ + + + L F+V AL + A+ QL+ DS
Sbjct: 1671 QTCRHLTAQV---RSLEAQVAHADQQLR-DLGKFQVATDALKSREPQAKPQLDLSIDS 1724
Score = 95.1 bits (235), Expect = 2e-19
Identities = 151/728 (20%), Positives = 302/728 (41%), Gaps = 114/728 (15%)
Query: 39 QKSQRFKQQKESKQNLNVDKD---TTLPASARKVKSSESKKESQKND--KDLKILEKEIR 93
Q +Q +QQ+++ Q L + ++L +++K K+E+ + D + L +E
Sbjct: 534 QLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEERE 593
Query: 94 VLLQERGAQDRRIQDLETE----LEKMEARLNAALREKTSLSANNATLEKQLIELTRTNE 149
L+ER A ++++ LE E LE ++ +L A + S + +++ EL+R E
Sbjct: 594 ASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVE 653
Query: 150 LLKSKFS---ENGNQKNLRILSLEL-MKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 205
L++ + ++ ++ LEL ++ ++ T+ + +++ ++ +LQ + SL+
Sbjct: 654 ELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKV 713
Query: 206 SQGKIAQLEGKLVSIEKEK---IDE-KSETEKLLEYIEEISCASDQVEKYKLDIAQLEEN 261
++G + + + + +E+ I E K+ET L +E+ ++E+ + LE
Sbjct: 714 TKGSLEEEKRRAADALEEQQRCISELKAETRSL---VEQHKRERKELEEERAGRKGLEAR 770
Query: 262 LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK-------EDHVNRNREHNEN 314
L++ + + + L + +C+ L KE ED ++
Sbjct: 771 LQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAM 830
Query: 315 LNAEMQNLKQKFILEQQEREKLQQK--------ELQIDSLLQQEKELSSSLHQKLCSFQE 366
++ LK++ +QE ++ ++K ELQI + EL ++L + L QE
Sbjct: 831 FQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQE 890
Query: 367 EMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 426
+ V+ + L D+L LQ+K + V +LE + E+ + +L + A
Sbjct: 891 KEVRAQKL--------ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPA 942
Query: 427 -----------ELEKSSAAHTQATL-LLQEKYDSMVQSLEDVTA-------QFESYKALT 467
E + TQA L ++ + + M LE + A Q + +
Sbjct: 943 RAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQ 1002
Query: 468 ASEIEDLKLENSSLQ-----EKAAKAG-----KNA------------EDVQHQILATESS 505
E+ L E Q EKAA+A +NA E + H + E
Sbjct: 1003 EREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGK 1062
Query: 506 NQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAE 565
+QE ++ L+ +IKE L+++ QLK+Q K+ G ++E
Sbjct: 1063 DQELAKL-------RGLEAAQIKE-----LEELRQTVKQLKEQLAKKEKEHASGSGAQSE 1110
Query: 566 KENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFE---VEKQALLNEHGAAQEQLNKI 622
T ++ R +L + + Q Q D+ E ++A E +A E L
Sbjct: 1111 AAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQ 1170
Query: 623 RDSYAKLLGHQN------------LKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE 670
+ A+ LGH + K++ K +DE K++V++ R + +K
Sbjct: 1171 LEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDE---WKAQVARGRQEAERKNSLI 1227
Query: 671 TKLQEELN 678
+ L+EE++
Sbjct: 1228 SSLEEEVS 1235
Score = 88.6 bits (218), Expect = 2e-17
Identities = 146/676 (21%), Positives = 273/676 (40%), Gaps = 103/676 (15%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSSESKKESQ--------KNDKDLKI----LEKEIR 93
QQ+ + L +K P ++++ K ES K +DLK ++++I
Sbjct: 255 QQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKIN 314
Query: 94 VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSAN----NATLEKQLIE------ 143
L +E G ++++ + L++++ LN E + + A LEK+L
Sbjct: 315 QLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKK 374
Query: 144 -LTRTNELLKSKFSE----------NGNQKNLRILS--LELMKLRNKRETKMRGMMAKQE 190
L NE+L+ K S+ N Q+ +L L+L L+ + T Q
Sbjct: 375 CLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQA 434
Query: 191 GMEM----------KLQVTQRSLEESQGKIAQLEGKL------VSIEKEKIDEKSE---- 230
+EM KL + EE + +++ L L +S KE++++ S+
Sbjct: 435 RVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGA 494
Query: 231 --TEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVE 288
T ++ E++ + +++ ++A L++ KEK ++ Q E+ L QVE
Sbjct: 495 RLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVE 554
Query: 289 DLNVKCQLLEKE-----------KEDHVNRNREHNENLNAEMQN----LKQKFILEQQER 333
L+ + E++ ++DH + E A ++ LKQ LE+++
Sbjct: 555 QLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKA 614
Query: 334 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKE 393
KL+ + Q LQ E S + Q E + EE Q E + +Q E
Sbjct: 615 AKLEILQQQ----LQVANEARDSAQTSVTQAQREKAELSRKVEE--LQACVETARQEQHE 668
Query: 394 EQAE--RLVKQLEEEAKSRAEELKLLEEKLKGKEA-ELEKSSAAHTQATLLLQEKYDSMV 450
QA+ L QL E + E+ ++ +EK + +E + K S T+ +L +E+
Sbjct: 669 AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL--EEEKRRAA 726
Query: 451 QSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILA------TES 504
+LE+ KA T S +E K E L+E+ +AG+ + + Q L TE
Sbjct: 727 DALEEQQRCISELKAETRSLVEQHKRERKELEEE--RAGRKGLEARLQQLGEAHQAETEV 784
Query: 505 SNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD-----------LQNQLKQQEEDFR 553
+E + T + E +KE+ ++ ++ D Q QL +E+
Sbjct: 785 LRRELAEAMAAQHTAESECEQLVKEVA-AWRERYEDSQQEEAQYGAMFQEQLMTLKEECE 843
Query: 554 KQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 613
K ++ + K + + +I++ + EL+ Q+ EV Q L ++
Sbjct: 844 KARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLS 903
Query: 614 AAQEQLNKIRDSYAKL 629
QE++ A+L
Sbjct: 904 TLQEKMAATSKEVARL 919
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 125 bits (315), Expect = 1e-28
Identities = 160/693 (23%), Positives = 302/693 (43%), Gaps = 65/693 (9%)
Query: 47 QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKE--IRVLLQERGAQDR 104
Q++ K L + L S K + E + K + E E +R L QE
Sbjct: 508 QEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRT 567
Query: 105 RIQDLETELEK-MEARLNAALREKTSLSANNATLEKQL---IELTRTN-ELLKSKFSENG 159
RI +LE+ LEK ++ N + L A K++ +E +T E LK +
Sbjct: 568 RILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALW 627
Query: 160 NQKNLRILS----LELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGK-IAQLE 214
+K L++L E+ KLR K E + ++ +E + Q +EE K + +L+
Sbjct: 628 TEK-LQVLKQQYQTEMEKLREKCEQEKETLLKDKE------IIFQAHIEEMNEKTLEKLD 680
Query: 215 GKLVSIEK--EKIDEKSETEKLLEYIEEISCASDQVEKYKLDI-AQLEENLKEKNDEILS 271
K +E ++ E + LE EE+S DQ +K K ++ A+++E ++ S
Sbjct: 681 VKQTELESLSSELSEVLKARHKLE--EELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDS 738
Query: 272 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 331
+ + E +I K ++D + +LL KE++ H+ ++ H ENL A+++ + +
Sbjct: 739 IIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA 798
Query: 332 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQ 391
+ + Q + + +E + L QKL + E + E Q D +L
Sbjct: 799 KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDA 858
Query: 392 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 451
+ Q + L++QLE++ +++K L + E++LE + Q +L EK + ++Q
Sbjct: 859 HKIQVQDLMQQLEKQNSEMEQKVKSLTQVY---ESKLEDGNKEQEQTKQILVEKENMILQ 915
Query: 452 SLE-----------DVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQIL 500
E ++A+ +S L K + +++ KA + E ++ ++L
Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975
Query: 501 ATESS-NQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEED-------- 551
E+ +E L+L K ++ E+ + I+D ++L+ +++
Sbjct: 976 DQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035
Query: 552 FRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL--- 608
R++L D +K N AE +EI++ +L +E + + ++ F EK+ +
Sbjct: 1036 HRRELNDVISIWEKKLNQQAEELQEIHEIQL--QEKEQEVAELKQKILLFGCEKEEMNKE 1093
Query: 609 ---LNEHGAAQE-QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLA 664
L E G Q+ LN+++ + LKQK HV L + ++LK+ + KL L
Sbjct: 1094 ITWLKEEGVKQDTTLNELQ---------EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLN 1144
Query: 665 KKKQSETKLQEELNKVLGIKHFDPSKAFHHESK 697
K + T LQE+L ++ + D K SK
Sbjct: 1145 KSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
Score = 110 bits (274), Expect = 6e-24
Identities = 158/687 (22%), Positives = 300/687 (43%), Gaps = 109/687 (15%)
Query: 88 LEKEIRVLLQERGAQD-------RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQ 140
LE ++R L +E+ + ++++ E +++ M+A + + + EK +L ++
Sbjct: 1274 LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQA 1333
Query: 141 LIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQ 200
E LK + SEN N ++ LMK K + K E + Q+T
Sbjct: 1334 ASEKESCITQLKKELSENIN-------AVTLMKEELKEK--------KVEISSLSKQLTD 1378
Query: 201 RSLE-ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLE 259
+++ ++ +++ E + S+ K+ +EK E LL+ ++++S D + K K+ +
Sbjct: 1379 LNVQLQNSISLSEKEAAISSLRKQYDEEKCE---LLDQVQDLSFKVDTLSKEKISALEQV 1435
Query: 260 ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKE---KEDHVNRNREHNENLN 316
++ K E K+ + V++L ++ +L KE K++ +N +E + N
Sbjct: 1436 DDWSNKFSE---WKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQN 1492
Query: 317 AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEK----ELSSSLHQKLCSFQE--EMVK 370
LK + + ++ K+++KE +++ L+ + EL + QK + E++K
Sbjct: 1493 KRFDCLKGEM---EDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIESLNEVLK 1549
Query: 371 ----EKNLFEEELKQTLDELDKLQQKEE----QAERLVKQLEEEAKSRAEEL-------- 414
+K++ +EL Q L +L ++++ +AE + LE + S EL
Sbjct: 1550 NYNQQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELE 1609
Query: 415 ------KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMV--QSLEDVTAQFESYKAL 466
K EE+LK E LE SAA E+ + + Q L + + E YK
Sbjct: 1610 HVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKG 1669
Query: 467 TASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETE 526
T S + +L N+ LQE+ + ++ ++ + ESS E +++ K+ TE
Sbjct: 1670 TESHLSEL---NTKLQERE----REVHILEEKLKSVESSQSE--TLIVPRSAKNVAAYTE 1720
Query: 527 IKE------ITVSFLQKITDLQNQLKQQEEDFRKQLEDEE--------------GRKAEK 566
+E + ++ +KI+ LQ L ++E+ ++ +++E R +
Sbjct: 1721 QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKL 1780
Query: 567 ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 626
E+ A+ E+ + L EEL K K + L + A VEK+ N A Q N D
Sbjct: 1781 EHAEAKQHEDQSMIGHLQEELEEKNKKYSL-IVAQHVEKEGGKNNIQAKQNLENVFDDVQ 1839
Query: 627 AKL----LGHQNLKQKIKH----VVKLKD----ENSQLKSEVSKLRC-QLAKKKQSETKL 673
L L Q L+QKIK +V+ K+ E +L S+ KL+ Q + T+L
Sbjct: 1840 KTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTEL 1899
Query: 674 QEELNKVLGIKHF-DPSKAFHHESKEN 699
EE + H P + E++ N
Sbjct: 1900 LEENTEEKSKSHLVQPKLLSNMEAQHN 1926
Score = 105 bits (261), Expect = 2e-22
Identities = 162/722 (22%), Positives = 298/722 (41%), Gaps = 102/722 (14%)
Query: 47 QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRI 106
Q+ KQN +++ + K + KE ++ + L +EKE ++LQ R Q + I
Sbjct: 868 QQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQIL--VEKE-NMILQMREGQKKEI 924
Query: 107 QDLETELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTNELLKSKF--SENGNQKN 163
+ L +L E ++ E +T +EK + E LK K E +K
Sbjct: 925 EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKE 984
Query: 164 LRILSLELMKLRNKRETKMRGM-MAKQEGME---MKLQVTQRSLEESQGKIAQLE-GKLV 218
L +LEL + + KM M A G+ +L+ Q+ ES ++ + E ++
Sbjct: 985 LENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVI 1044
Query: 219 SIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL-------KEKNDEILS 271
SI ++K+++++E L+ I EI Q+++ + ++A+L++ + +E N EI
Sbjct: 1045 SIWEKKLNQQAEE---LQEIHEI-----QLQEKEQEVAELKQKILLFGCEKEEMNKEITW 1096
Query: 272 LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ 331
LK+ + L++ E L K+K HVN + L A ++ L+ +
Sbjct: 1097 LKEEGVKQDTTLNELQEQL--------KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLK 1148
Query: 332 EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDE-LDKLQ 390
E LQ++ +++ L +++K S L KL + EE K+ E+ K D+ L+ +
Sbjct: 1149 ENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKK 1208
Query: 391 QKEEQAERL---VKQLEEEAKSRAEELKLLEEK----------------LKGKEA----- 426
EE A +L K+ E +++ EL + K KEA
Sbjct: 1209 LSEELAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKT 1268
Query: 427 ----ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQ 482
ELE T+ L + LE+ Q +S KA +IE L E +LQ
Sbjct: 1269 CTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKA----DIESLVTEKEALQ 1324
Query: 483 EKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQ 542
++ + A + + I + E + + ++ + K+ EI ++ LQ
Sbjct: 1325 KEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQ 1384
Query: 543 NQLKQQEED-----FRKQLEDEEGRKAE-------------KENTTAELTEEINKWRLLY 584
N + E++ RKQ ++E+ + KE +A E+++ W +
Sbjct: 1385 NSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISA--LEQVDDWSNKF 1442
Query: 585 EEL-----------YNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ 633
E N K Q+QL+ E + +E+L++ + L G
Sbjct: 1443 SEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEM 1502
Query: 634 NLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFH 693
K K K + ++LKS+ +++ +L +T E LN+VL K+++ K
Sbjct: 1503 E-DDKSKMEKKESNLETELKSQTARI-MELEDHITQKTIEIESLNEVL--KNYNQQKDIE 1558
Query: 694 HE 695
H+
Sbjct: 1559 HK 1560
Score = 97.8 bits (242), Expect = 3e-20
Identities = 147/649 (22%), Positives = 287/649 (44%), Gaps = 84/649 (12%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
QK Q F Q L +KD + + K+ + E++ S K + + K +KE+ +
Sbjct: 1564 QKLQHF-------QELGEEKDNRVKEAEEKILTLENQVYSMKAELETK--KKELEHVNLS 1614
Query: 99 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
+++ ++ LE LE A A L+ K A ++KQL L++ E K + +
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKI--AAIKKQL--LSQMEE--KEEQYKK 1668
Query: 159 GNQKNLRILSLELMKLRNK---RETKMRGMMAKQ-------EGMEMKLQVTQRSLEESQG 208
G + +L L+ +L + + E K++ + + Q + T++ +SQG
Sbjct: 1669 GTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQG 1728
Query: 209 KIAQLEGKLVSIEKEKIDEKSETEKLLEYI-----EEISCASDQVEKYKLDIAQLEENLK 263
+ + + +S+ + + EK EKLL+ + E +S + +Y+ + +LE
Sbjct: 1729 CVQKTYEEKISVLQRNLTEK---EKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEA 1785
Query: 264 EKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLK 323
+++++ + I L +++E+ N K L+ + HV + N N+ A+ QNL+
Sbjct: 1786 KQHED--------QSMIGHLQEELEEKNKKYSLIVAQ---HVEKEGGKN-NIQAK-QNLE 1832
Query: 324 QKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 383
F ++ LQ+KEL L Q+ KEL S L ++ + EM EEL
Sbjct: 1833 NVF---DDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEM--------EELTSKY 1881
Query: 384 DELDKLQQ---KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 440
++L LQQ + + E L + EE++KS + KLL ++ + +LE A +
Sbjct: 1882 EKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLL-SNMEAQHNDLEFKLAGAEREKQ 1940
Query: 441 LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQIL 500
L ++ + + L + + + E+E LK E QE+ K + ED++ +
Sbjct: 1941 KLGKEIVRLQKDLRMLRKEHQ-------QELEILKKEYD--QEREEKIKQEQEDLELK-- 1989
Query: 501 ATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEE 560
N +++ + T+ A KE E++ + K +++ +L + ++ QL +
Sbjct: 1990 ----HNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKI 2045
Query: 561 GRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 620
K + TA+ EEI R EE+ K + Q QL+ + + Q L +++ N
Sbjct: 2046 AEKDDDLKRTAKRYEEILDAR--EEEMTAKVRDLQTQLEELQKKYQQKL------EQEEN 2097
Query: 621 KIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS 669
D+ + L QK + K + + + ++ L +L K +++
Sbjct: 2098 PGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKN 2146
Score = 93.6 bits (231), Expect = 6e-19
Identities = 163/707 (23%), Positives = 310/707 (43%), Gaps = 123/707 (17%)
Query: 26 VKTLEV---LKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKND 82
VK L++ LK +++K ++ KE N D L KS KKES
Sbjct: 1460 VKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDC-LKGEMEDDKSKMEKKESN--- 1515
Query: 83 KDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI 142
LE E++ +Q RI +LE + + + + + + K+L+
Sbjct: 1516 -----LETELK-------SQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELV 1563
Query: 143 ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 202
+ + F E G +K+ R+ E L E ++ M A+ E + +L+ S
Sbjct: 1564 QKLQ-------HFQELGEEKDNRVKEAEEKIL--TLENQVYSMKAELETKKKELEHVNLS 1614
Query: 203 LEESQGKIAQLEGKLVSIEKEKIDE-KSETEKLLEYIEE--ISCASDQVEKYK----LDI 255
++ + ++ LE +L S K+ E K + E+ + I++ +S ++ E+YK +
Sbjct: 1615 VKSKEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHL 1674
Query: 256 AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL-------NVKCQLLEKEKEDHVNRN 308
++L L+E+ E+ L++ L+ + S Q E L NV ++E +
Sbjct: 1675 SELNTKLQEREREVHILEEKLKS---VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQ 1731
Query: 309 REHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKL-CSFQEE 367
+ + E ++ +NL E+EKL Q+ + QEKE + S H ++ C +QE
Sbjct: 1732 KTYEEKISVLQRNL--------TEKEKLLQR-------VGQEKEETVSSHFEMRCQYQER 1776
Query: 368 MVKEKNLFEEELKQTLDE------LDKLQQKEEQAERLVKQLEE--------EAKSRAEE 413
++K L E KQ D+ ++L++K ++ +V Q E +AK E
Sbjct: 1777 LIK---LEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLEN 1833
Query: 414 L-----KLLEEK------LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFES 462
+ K L+EK L+ K EL+ + L+++K V+ +E++T+++E
Sbjct: 1834 VFDDVQKTLQEKELTCQILEQKIKELD---------SCLVRQKEVHRVE-MEELTSKYEK 1883
Query: 463 YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL 522
+AL +++ L+E + K+ H + SN E L+ + A
Sbjct: 1884 LQAL--QQMDGRNKPTELLEENTEEKSKS-----HLVQPKLLSNMEAQHNDLEFKLAGAE 1936
Query: 523 KETEIKEITVSFLQK-ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWR 581
+E + + LQK + L+ + +Q+ E +K+ + E K ++E EL +
Sbjct: 1937 REKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQ 1996
Query: 582 LLYE---ELYNKTKPFQLQL-----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ 633
L+ E +L K + ++ + A EVE + LL H QE+ N++ A+
Sbjct: 1997 LMREFNTQLAQKEQELEMTIKETINKAQEVEAE-LLESH---QEETNQLLKKIAE--KDD 2050
Query: 634 NLKQKIKHVVKLKD-ENSQLKSEVSKLRCQLAK-KKQSETKLQEELN 678
+LK+ K ++ D ++ ++V L+ QL + +K+ + KL++E N
Sbjct: 2051 DLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEEN 2097
Score = 90.5 bits (223), Expect = 5e-18
Identities = 147/695 (21%), Positives = 302/695 (43%), Gaps = 103/695 (14%)
Query: 68 KVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREK 127
+V S ES S + + KE V R + +R D T + +++ E
Sbjct: 68 RVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDLDSSTASFDPPSDMDS---EA 124
Query: 128 TSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNL----RILSLELMKLRN----KRE 179
L N+ +L K+ + + R + +S S G L ++L E KL+ ++
Sbjct: 125 EDLVGNSDSLNKEQL-IQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQD 183
Query: 180 TKMRGMMAKQEGMEMKLQVTQR-------SLEESQGKIAQLEGKLVSIEKEKIDEKSETE 232
+R + +E ++M Q + SLEE I+ L+ + VS+ K+++
Sbjct: 184 KSLRRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQTQ-VSLLKQRLRNGPMNV 242
Query: 233 KLLEYIEEISCASDQVEKYKLDIAQ----LEENLKEKNDEILSLKQSLEENIVILSKQ-V 287
+L+ + ++ ++ K + + +E+ K E L + +EN++ K+ +
Sbjct: 243 DVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETI 302
Query: 288 EDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL 347
+ +C LL EKE E L+ +Q L++ L E+ KL + +L+
Sbjct: 303 QSHKEQCTLLTSEKE-------ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLI 355
Query: 348 QQEK--------ELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399
+Q + E +H+ L +EE+ + ++ +KQ + ++L++++E++ER
Sbjct: 356 EQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS----RIKQMTTQGEELREQKEKSERA 411
Query: 400 VKQLEEEAKSRAEELKLLEEKLKGKEAE----LEKSSAAHTQATLLLQEKYDSMVQSLED 455
+ E+A S A++ + KLK + E +EK+S + + LQ++ + Q + D
Sbjct: 412 AFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSE---EERISLQQELSRVKQEVVD 468
Query: 456 VTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI-LATESSNQEYVRML- 513
V + + ++ + +L QE K + Q Q+ +A E S EY+++
Sbjct: 469 VMKKSSEEQIAKLQKLHEKELARKE-QELTKKLQTREREFQEQMKVALEKSQSEYLKISQ 527
Query: 514 ------------LDLQTKSALKETE-----IKEITVSFLQKITDLQNQLKQQEEDFRKQL 556
L+LQ K+ L E+E +++ ++ +I +L++ L++ ++ + Q
Sbjct: 528 EKEQQESLALEELELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQS 587
Query: 557 ED-EEGRKAEKENTTAELTEEINKWRLLYEELYNK-----TKPFQLQLDAFEVEKQALLN 610
+D +AEK E+T + K + E L ++ T+ Q+ ++ E + L
Sbjct: 588 KDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE 647
Query: 611 EHGAAQEQLNK---------IRDSYAKLLGHQNLKQ--------------KIKHVVKLKD 647
+ +E L K I + K L ++KQ K +H KL++
Sbjct: 648 KCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARH--KLEE 705
Query: 648 ENSQLKSEVSKLRCQL-AKKKQSETKLQEELNKVL 681
E S LK + K++ +L AK + + Q++++ ++
Sbjct: 706 ELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740
Score = 79.0 bits (193), Expect = 1e-14
Identities = 125/603 (20%), Positives = 248/603 (41%), Gaps = 109/603 (18%)
Query: 29 LEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKIL 88
+ +K + Q ++ +Q K+ ++ + +T L R+V E K +S ++ + ++
Sbjct: 1648 IAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETLI 1707
Query: 89 ----EKEIRVLLQERGAQ---------DRRIQDLETELEKMEARLNAALREKTSLSANNA 135
K + ++ A + +I L+ L + E L +EK +++
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767
Query: 136 TLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMK 195
+ Q E R +L ++ ++ +Q + L EL + +NK+ + + ++EG +
Sbjct: 1768 EMRCQYQE--RLIKLEHAEAKQHEDQSMIGHLQEELEE-KNKKYSLIVAQHVEKEGGKNN 1824
Query: 196 LQV----------TQRSLEESQGKIAQLEGKLVSIE----KEKIDEKSETEKLLEYIEEI 241
+Q Q++L+E + LE K+ ++ ++K + E E+L E++
Sbjct: 1825 IQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKL 1884
Query: 242 SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK 301
A Q++ LEEN +EK+ L + L + Q DL K E+EK
Sbjct: 1885 Q-ALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSN----MEAQHNDLEFKLAGAEREK 1939
Query: 302 E-----------DHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQID------ 344
+ D +EH + E++ LK+++ E++E+ K +Q++L++
Sbjct: 1940 QKLGKEIVRLQKDLRMLRKEHQQ----ELEILKKEYDQEREEKIKQEQEDLELKHNSTLK 1995
Query: 345 --------SLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQA 396
L Q+E+EL ++ + + QE E L E ++T L K+ +K++
Sbjct: 1996 QLMREFNTQLAQKEQELEMTIKETINKAQEV---EAELLESHQEETNQLLKKIAEKDDDL 2052
Query: 397 ERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLED- 455
+R K+ EE +R EE + K++ + +LE+ LQ+KY ++ E+
Sbjct: 2053 KRTAKRYEEILDAREEE---MTAKVRDLQTQLEE-----------LQKKYQQKLEQEENP 2098
Query: 456 -----VTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT-------- 502
+ ++ A + I D KL+ +E+ + + + AT
Sbjct: 2099 GNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKKYEKNVYATTVGTPYKG 2158
Query: 503 ------------ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEE 550
E + EY+R +L +T K IT + K D Q Q + E
Sbjct: 2159 GNLYHTDVSLFGEPTEFEYLRKVLFEYMMGRETKTMAKVITT--VLKFPDDQTQKILERE 2216
Query: 551 DFR 553
D R
Sbjct: 2217 DAR 2219
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 124 bits (311), Expect = 3e-28
Identities = 171/764 (22%), Positives = 331/764 (43%), Gaps = 109/764 (14%)
Query: 38 FQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQ 97
F K + ++S++ V+ + S K+ + Q+++K L+ LEKEI+ L +
Sbjct: 762 FLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLE-LEKEIKCLQE 820
Query: 98 ERGAQDRRIQD-----------LETELEKMEARLNAA---------LREKTSLSANNATL 137
E Q ++ L ELE++++ A EKT L N +
Sbjct: 821 ESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLI 880
Query: 138 EKQLIELTRT-----NELLKSKFSENGN------QKNLRILSLELMKLRN---KRETKMR 183
+ + + T + NE K E+ N QK LR EL+ L++ K +
Sbjct: 881 QVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKN 940
Query: 184 GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISC 243
++ + +E K++ ++ +E + KI +++ V +KE + ET+ + E +E +
Sbjct: 941 DPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRS 1000
Query: 244 ASDQVEKYKLDIAQLEENLK------EKNDEILSLKQ----SLEENIVILSKQVEDLNVK 293
DQ+ D+ Q E+ K EK E L +++ + E I L++Q+ + ++
Sbjct: 1001 EKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQ 1060
Query: 294 CQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEK-E 352
C+ + + ED + R N L + ILE Q + + KEL+ + L +++K +
Sbjct: 1061 CETINSDNEDLLARIETLQSN-----AKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1115
Query: 353 LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQA----------ERLVKQ 402
++ +L Q ++ KEK ++L++T+ EL+ +++ +Q ERL+K+
Sbjct: 1116 EHATTVNELEELQVQLQKEK----KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKE 1171
Query: 403 --------------LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL----QE 444
LE+E K + ++ + L+E++ ++ +++ +T+ LL +E
Sbjct: 1172 LNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKE 1231
Query: 445 KYDSMVQSLEDVTAQFESYKALTAS--EIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 502
DS + + Q L AS ++E K++ + + + K ++ + Q T
Sbjct: 1232 LADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRT 1291
Query: 503 ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 562
S+ Q+ V LQ + + E +T F + N LKQQ+ Q E EG
Sbjct: 1292 LSAYQQRVTA---LQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAE-TEGA 1347
Query: 563 KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK- 621
K E+E+ +L ++L K + Q L E Q L +EH E+ NK
Sbjct: 1348 KQEREHL-----------EMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKM 1396
Query: 622 IRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 681
++++ +K L++K+ ++ EN +KSE ++ QL + + + + L
Sbjct: 1397 LQETVSK---EAELREKL---CSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHL 1450
Query: 682 GIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 725
+H + + + A LK T R+P+ Q+S K
Sbjct: 1451 QEEHRKTVETLQQQLSKMEAQLFQLKNEPTT--RSPVSSQQSLK 1492
Score = 103 bits (257), Expect = 6e-22
Identities = 136/667 (20%), Positives = 292/667 (43%), Gaps = 70/667 (10%)
Query: 33 KGPVSFQKSQRFKQQKESKQNLNVDKDTT-LPASARKVKSSESKKESQKND--KDLKILE 89
K + +K + F ++ E+ + L K+ A +K S +K S KND +K LE
Sbjct: 891 KSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELE 950
Query: 90 KEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKT-------SLSANNATLEKQLI 142
++I L +E ++ +I ++ K + L+++ +E SL + L +
Sbjct: 951 EKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMR 1010
Query: 143 ELTRTNELLKSKFSENGNQKNLRILSLELMKLR-NKRETKMRGMMAKQEGMEMKLQVTQR 201
+L + E K+ E Q L++ K R N E ++ + + ++ +
Sbjct: 1011 DLIQGAESYKNLLLEYEKQSE----QLDVEKERANNFEHRIEDLTRQLRNSTLQCETINS 1066
Query: 202 SLEESQGKIAQLEG--KLVSIE-------KEKIDEKSETEKLLEYIEEISCASDQVEKYK 252
E+ +I L+ KL+ ++ K +D++ E EKL + +++++
Sbjct: 1067 DNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQK--------EQKIKEHA 1118
Query: 253 LDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN 312
+ +LEE + E L+++++E + ++ K + L+ E D+ +E N
Sbjct: 1119 TTVNELEELQVQLQKEKKQLQKTMQE-LELVKKDAQQTT----LMNMEIADYERLMKELN 1173
Query: 313 ENL---NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMV 369
+ L N ++++L+Q+ +++Q++E LQ++ + S +QQ +E ++ + Q L ++E+
Sbjct: 1174 QKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELA 1233
Query: 370 KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELE 429
K + L +L+ ++Q E QL E + + + E LK + +
Sbjct: 1234 DSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHK----IHEHLKTSAEQHQ 1289
Query: 430 KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAG 489
++ +A+ Q LQE+ + VT++FESYK + ++ K N S+ + +
Sbjct: 1290 RTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQK--NKSMSQAETEGA 1347
Query: 490 KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIK-EITVSFLQKITDLQNQLKQQ 548
K +E++ ML+D Q K L++++ +I VS LQ LQ++
Sbjct: 1348 K--------------QEREHLEMLID-QLKIKLQDSQNNLQINVSELQ---TLQSEHDTL 1389
Query: 549 EEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNK-TKPFQLQLDAFEVEKQA 607
E K L++ ++AE + E + + + ++ T ++ ++F + +
Sbjct: 1390 LERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRH 1449
Query: 608 LLNEH----GAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQL 663
L EH Q+QL+K+ +L + + LK+ + +++ L
Sbjct: 1450 LQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHT 1509
Query: 664 AKKKQSE 670
+++ E
Sbjct: 1510 VTREEGE 1516
Score = 100 bits (250), Expect = 4e-21
Identities = 142/702 (20%), Positives = 316/702 (45%), Gaps = 86/702 (12%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKND--KDLKI--------- 87
Q Q+ ++ + L+ DK+ L A + + +K S+K +DL++
Sbjct: 661 QNDQKLEKLMVQMKVLSEDKEV-LSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVI 719
Query: 88 -------LEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQ 140
LEK+++++++E+ ++ +++ + + ++ +L L+E S + ++ +
Sbjct: 720 LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDV 779
Query: 141 LIELTRTNELLKSKFSENGN---QKNLRILSL--ELMKLRNKRETKMRGMMAKQEGMEMK 195
+ L E L E N Q++ ++L L E+ L+ + + + + E +
Sbjct: 780 VNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQE 839
Query: 196 LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS--CASDQV--EKY 251
+ ++ LEE Q + L+ L+ ++ + E + LL +EE+S C+ ++ EK
Sbjct: 840 KVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKE 899
Query: 252 KLDIAQLE--------ENLKEKNDEILSLKQSLEENIVILS---KQVEDLNVKCQLLE-- 298
K I + E + L+++ E++ LK SL ++ + + V++L K + LE
Sbjct: 900 KCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKE 959
Query: 299 -KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL 357
KEKE+ +N+ ++ +K K L+ +E KE +++SL ++ +LS+S+
Sbjct: 960 CKEKEEKINK---------IKLVAVKAKKELDSSRKETQTVKE-ELESLRSEKDQLSASM 1009
Query: 358 HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 417
+ + KNL E KQ+ ++LD +++ E ++ L + ++ + + +
Sbjct: 1010 RDLI----QGAESYKNLLLEYEKQS-EQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI 1064
Query: 418 EEKLKGKEAELE--KSSAAHTQATLLLQEKYDSMV-QSLEDVTAQFE---SYKALTASEI 471
+ A +E +S+A + +L ++ +MV + LE Q E A T +E+
Sbjct: 1065 NSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNEL 1124
Query: 472 EDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE---YVRMLLDLQTKSALKETEIK 528
E+L+++ +++ K + E V+ T N E Y R++ +L K K +I+
Sbjct: 1125 EELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIE 1184
Query: 529 EI----------TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEIN 578
++ + ++IT LQ+ ++Q EE K + K E ++ T+ +
Sbjct: 1185 DLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHL- 1243
Query: 579 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 638
+L L + + Q Q++ ++++ + +E E L + + + L
Sbjct: 1244 ---ILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQ---- 1296
Query: 639 IKHVVKLKDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNK 679
+ V L++E K+E + + + + K + L+++ NK
Sbjct: 1297 -QRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNK 1337
Score = 92.8 bits (229), Expect = 1e-18
Identities = 132/652 (20%), Positives = 282/652 (43%), Gaps = 82/652 (12%)
Query: 66 ARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALR 125
A + K SE K QK ++ + E+ L+ + + ++ L+ E+EK+ +
Sbjct: 140 AVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQIL 199
Query: 126 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 185
+AT +++ +T+ ++++ + QKN+ L EL++L+ + +++ +
Sbjct: 200 YLQKQL--DATTDEKKETVTQLQNIIEA--NSQHYQKNINSLQEELLQLKAIHQEEVKEL 255
Query: 186 MAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS 245
M + E S +E + +I KL +++ + + +EK ++
Sbjct: 256 MCQIEA----------SAKEHEAEI----NKLNELKENLVKQCEASEKNIQ--------- 292
Query: 246 DQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEK- 301
+KY+ ++ L + N + L+EN +++++V+ L + LE +
Sbjct: 293 ---KKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHS 349
Query: 302 --EDHVNRNREHNENLNAEMQNLKQKFILEQQE-----REKLQQKELQIDSLLQQEKELS 354
+D V L + Q++K +F E+++ E L KE Q ++++ K
Sbjct: 350 ILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQ-GCVIEKLKSEL 408
Query: 355 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL 414
+ L+++ C E+ +E +E+ ++ + EL++ + + E+L E+
Sbjct: 409 AGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMF---------EI 459
Query: 415 KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDL 474
+ L+E+ + + E +++ + +++ + +S ++ +FES K AS++ +L
Sbjct: 460 QGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHEL 519
Query: 475 K-------LENSSLQEKAAK-AGKNAEDVQHQILATESSN-------QEYVRMLLDLQTK 519
+ E +L E + G+N + + Q L E N + V +L Q
Sbjct: 520 QQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRD 579
Query: 520 SALKETEIKEITVSFLQKITDLQNQLKQQEED---FRKQLEDEE------GRKAEKE-NT 569
+ LKE E K S ++ D N+LK E+ F K+ E EE G+K E+
Sbjct: 580 TMLKELEGK--INSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQY 637
Query: 570 TAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL 629
+EL +++N+ EE + +L+ V+ + L + ++ + + KL
Sbjct: 638 NSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKL 697
Query: 630 LGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 681
+ + V + E+ LK ++ QL KK Q + Q+ LNK+L
Sbjct: 698 SSEKKQLSRDLEVFLSQKEDVILKEHIT----QLEKKLQLMVEEQDNLNKLL 745
Score = 78.6 bits (192), Expect = 2e-14
Identities = 148/719 (20%), Positives = 290/719 (40%), Gaps = 134/719 (18%)
Query: 78 SQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELE----KMEARLNAALREKTSLSAN 133
SQ K++ L++E LLQ + +++L ++E + EA +N K +L
Sbjct: 227 SQHYQKNINSLQEE---LLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQ 283
Query: 134 NATLEKQLIELTRTNELLKSKFSENGNQKN--LRILSLELMKLRNKRETKMRGMMAKQEG 191
EK + + K + N NQ N IL E + K++ + +
Sbjct: 284 CEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKE 343
Query: 192 MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETE----KLLEYIEEISCASDQ 247
+E + + + + +LE I+ E E+ + E +LL EE C
Sbjct: 344 LESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCV--- 400
Query: 248 VEKYKLDIAQLEEN----LKEKNDEILSLKQSLEENIVILSK---------------QVE 288
+EK K ++A L + +++ N E+ SLK+ ++ I L++ +++
Sbjct: 401 IEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQ 460
Query: 289 DLNVKCQLLEKEKEDHVNRNREHNE--------------NLNAEMQNLKQKFILEQQE-R 333
L +C+ L++EK++ + E ++ E +++KQ+ + E +
Sbjct: 461 GLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ 520
Query: 334 EKLQQKELQIDSLLQ-------------QEKELSSSLHQKLCSFQEE------------- 367
+KL+ + D+LL+ ++EL L + + QE+
Sbjct: 521 QKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT 580
Query: 368 -----------MVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKL 416
+ +EK+ F +LK + +E+D +K E+ ERL+ +L ++ + +
Sbjct: 581 MLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSE 640
Query: 417 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE---SYKALTASEIED 473
LE+K+ LE++ L+EK D Q LE + Q + K + ++E++
Sbjct: 641 LEQKVNELTGGLEET----------LKEK-DQNDQKLEKLMVQMKVLSEDKEVLSAEVKS 689
Query: 474 LKLENSSLQEKAAKAGKNAE---DVQHQILATESSNQEYVRMLLDLQTKSAL-KETEIKE 529
L EN+ L + + ++ E + ++ E Q ++ L ++ + L K E ++
Sbjct: 690 LYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQ 749
Query: 530 ITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYN 589
+ F +K Q F K++ E +E+++ L + EE N
Sbjct: 750 VQKLF----------VKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCN 799
Query: 590 KTKPFQLQLDAFEVEKQ-ALLNEHGAAQ-EQLNKIRDSYAKLLGHQNLKQKIKHVVKLKD 647
FQ E+EK+ L E Q E+L + Y + V L+
Sbjct: 800 LA--FQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYE------------QEKVLLRK 845
Query: 648 ENSQLKSEVSKLRCQLAKKKQSETKLQ-EELNKVLGIKHFDP--SKAFHHESKENFALK 703
E +++SE L+ L + K + K + E N ++ ++ SK+ H KE +K
Sbjct: 846 ELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIK 904
Score = 68.2 bits (165), Expect = 3e-11
Identities = 102/539 (18%), Positives = 235/539 (43%), Gaps = 66/539 (12%)
Query: 175 RNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL 234
++K ET + + K +M L +++++ + +LE ++ E++ K TE
Sbjct: 19 KSKLETLPKEDLIKFAKKQMML------IQKAKSRCTELEKEI-----EELRSKPVTEGT 67
Query: 235 LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKC 294
+ I+ ++ ++++ L+ A+ E+ E + +KQ +E+++ + ++L
Sbjct: 68 GDIIKALT---ERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKEL---- 120
Query: 295 QLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELS 354
++ H+N +E ENL E+ ++ K+ ++ +K ++ + L ++ +
Sbjct: 121 ------EQSHINYVKEI-ENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQ 173
Query: 355 SSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD-KLQQKEEQAERLVKQLEEEAK----- 408
++ + QEE+ K + FEE++ +LD +K+E +L +E ++
Sbjct: 174 NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKN 233
Query: 409 --SRAEELKLL----EEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLE-------- 454
S EEL L +E++K ++E S+ H L E +++V+ E
Sbjct: 234 INSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQK 293
Query: 455 DVTAQFESYKALTASEIED------LKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE 508
+ E+ + T++ +D L EN+ +++ + K+ ED ++ + S ++
Sbjct: 294 KYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKD 353
Query: 509 YVRMLLDLQTKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEGRKAE 565
V + +L+ K + IK+ F + DL+ N+L +E+ +E + A
Sbjct: 354 EVTYMNNLKLKLEMDAQHIKD---EFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAG 410
Query: 566 KENTTAELTEEINKWRLLYEELYNK--TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKI- 622
E+ N+ +E + K ++ + L E EK L+ E +EQ +
Sbjct: 411 LNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQ 470
Query: 623 RDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVL 681
++ +L +++L++ ++ + ++L K+ + KQ + EL + L
Sbjct: 471 QEKQEAILNYESLREIMEIL------QTELGESAGKISQEFESMKQQQASDVHELQQKL 523
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 123 bits (308), Expect = 7e-28
Identities = 121/546 (22%), Positives = 249/546 (45%), Gaps = 50/546 (9%)
Query: 172 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
MKL K + ++ ++E MK + T+ L +++ K +LE K+V++ +EK D +
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 230 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 282
+ + + + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 894 QVQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953
Query: 283 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 342
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+ Q
Sbjct: 954 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 343 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 402
LQ E++ ++L + ++++ + E+E K +D L++ + + E +K
Sbjct: 1010 TLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMD----LERAKRKLEGDLKL 1065
Query: 403 LEEEAKSRAEELKLLEEKLKGKEAELE--KSSAAHTQA-TLLLQEKYDSMVQSLEDVTAQ 459
+E + + L EKLK KE E+ + QA + LQ+K + +E++ +
Sbjct: 1066 AQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEE 1125
Query: 460 FESYKALTA---SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 516
E+ +A A + DL E + E+ +AG QI + E+ +M DL
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDL 1182
Query: 517 QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 576
+ + E + + +L Q+ + +++LE E+ + N A E
Sbjct: 1183 EESTLQHEATAAALRKKHADSVAELGEQIDSLQR-VKQKLEKEKSELKMEINDLASNMET 1241
Query: 577 INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL------ 630
++K + +E++ + ++ E E+Q L+NE A + +L+ +++ L
Sbjct: 1242 VSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAM 1301
Query: 631 ------GHQNLKQKIKHVVKLKDENSQLKSEVSK-----------LRCQLAKKKQSETKL 673
G Q Q+I+ + + +E ++ KS ++ LR Q ++++++ +L
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAEL 1361
Query: 674 QEELNK 679
Q ++K
Sbjct: 1362 QRGMSK 1367
Score = 111 bits (278), Expect = 2e-24
Identities = 146/706 (20%), Positives = 292/706 (41%), Gaps = 107/706 (15%)
Query: 68 KVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREK 127
K + ++K+E K + K LE+++ L+QE+ ++Q L E R + ++ K
Sbjct: 857 KEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAEERCDQLIKTK 916
Query: 128 TSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA 187
L A K++ E E + + EL + K E + +
Sbjct: 917 IQLEAK----IKEVTERAEDEEEINA----------------ELTAKKRKLEDECSELKK 956
Query: 188 KQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQ 247
+ +E+ L ++ ++ K+ L ++ ++ E I + ++ +K L+ +
Sbjct: 957 DIDDLELTLAKVEKEKHATENKVKNLTEEMAGLD-ETIAKLTKEKKALQ----------E 1005
Query: 248 VEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNR 307
+ LD Q+EE +K + + K LE+ + L +E C LE+ K
Sbjct: 1006 AHQQTLDDLQMEE---DKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAK------ 1056
Query: 308 NREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSL---LQQEKELSSSLHQKLCSF 364
R+ +L ++ +QQ EKL++KE ++ +L ++ E+ L+ L +K+
Sbjct: 1057 -RKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKEL 1115
Query: 365 QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL---KLLEEKL 421
Q + + + E E + + E + ++LEE + + ++ K E +
Sbjct: 1116 QARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEF 1175
Query: 422 KGKEAELEKSSAAHTQATLLLQEKY-DSM------VQSLEDVTAQFESYKALTASEIEDL 474
+ +LE+S+ H L++K+ DS+ + SL+ V + E K+ EI DL
Sbjct: 1176 QKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDL 1235
Query: 475 KLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEIT--- 531
++ + A K ++ Q+ ++ +E R++ +L + A TE E +
Sbjct: 1236 ASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQL 1295
Query: 532 --------------VSFLQKITDLQNQLKQQEED-----------------FRKQLEDEE 560
+F Q+I +L+ QL+++ + R+Q E+E+
Sbjct: 1296 DEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQ 1355
Query: 561 GRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 620
KAE + ++ E+ +WR YE T Q + + E K+ L A+E +
Sbjct: 1356 EAKAELQRGMSKANSEVAQWRTKYE-----TDAIQ-RTEELEEAKKKLAQRLQDAEEHVE 1409
Query: 621 KIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC-QLAKKKQSETKLQEELNK 679
+ A L + KQ++++ V E+ + E S C L KK+++ K+ E +
Sbjct: 1410 AVNSKCASL---EKTKQRLQNEV----EDLMIDVERSNAACIALDKKQRNFDKVLAEWKQ 1462
Query: 680 VLGIKHFDPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 725
K+ + KE+ +L T L + N Y ++ E+ K
Sbjct: 1463 ----KYEETQAELEASQKESRSLSTELFKVK-NAYEESLDHLETLK 1503
Score = 105 bits (261), Expect = 2e-22
Identities = 140/685 (20%), Positives = 307/685 (44%), Gaps = 71/685 (10%)
Query: 47 QKESKQNLNVDK-DTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRR 105
++E K +++++ L + + S E+ K + K+ +KE + + +D +
Sbjct: 1043 EQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQ 1102
Query: 106 IQ--DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKN 163
L+ ++++++AR+ E + A+ A EKQ +L+R E + + E G +
Sbjct: 1103 ALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATS 1162
Query: 164 LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG-KIAQLEGKLVSIEK 222
+I ++ KRE + + M E ++ + T +L + +A+L ++ S+++
Sbjct: 1163 AQI------EMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQR 1216
Query: 223 EKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 282
K + E +L I +++ + V K K + ++ L+++ EI + ++ + I
Sbjct: 1217 VKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINE 1276
Query: 283 LSKQVEDLNVKCQLLEK---EKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK---- 335
LS Q L+ + + EK+ V++ + +++ LK++ LE++ + K
Sbjct: 1277 LSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQ--LEEETKAKSTLA 1334
Query: 336 --LQQKELQIDSLLQQ---EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD--- 387
LQ D L +Q E+E + L + + E+ + + +E + Q +EL+
Sbjct: 1335 HALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAK 1394
Query: 388 -KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKY 446
KL Q+ + AE V+ + + S + + L+ +++ ++E+S+A A + L +K
Sbjct: 1395 KKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNA----ACIALDKKQ 1450
Query: 447 DSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSN 506
++ + V A+++ T +E+E + E+ SL + K E+ + + N
Sbjct: 1451 ----RNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKREN 1506
Query: 507 QEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR---- 562
+ + + DL + A I E+ +++ +++L+ E+ LE EEG+
Sbjct: 1507 KNLQQEISDLTEQIAEGGKHIHELE-KVKKQLDHEKSELQTSLEEAEASLEHEEGKILRI 1565
Query: 563 -------KAEKENTTAELTEEINKWR---LLYEELYNKTKPFQLQL--DAFEVEK--QAL 608
K+E + AE EE+++ + L E T +++ DA ++K +
Sbjct: 1566 QLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGD 1625
Query: 609 LNE--------HGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQ-------L 652
LNE + A E L +R++ L Q +L I+ LK++ + +
Sbjct: 1626 LNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLM 1685
Query: 653 KSEVSKLRCQLAKKKQSETKLQEEL 677
++EV +LR L + ++ ++EL
Sbjct: 1686 QAEVEELRASLERTERGRKMAEQEL 1710
Score = 88.2 bits (217), Expect = 2e-17
Identities = 143/661 (21%), Positives = 283/661 (42%), Gaps = 100/661 (15%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
Q+++ Q+ SK N V + T + ++ E ++ +K + L+ E+ + + +
Sbjct: 1355 QEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414
Query: 99 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
+ ++ Q L+ E+E + + + +L +K L E + E +++
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELE-- 1472
Query: 159 GNQKNLRILSLELMKLRNKRETKMRGMMA-KQEGMEMKLQVTQRSLEESQG--KIAQLEG 215
+QK R LS EL K++N E + + K+E ++ +++ + + ++G I +LE
Sbjct: 1473 ASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHIHELE- 1531
Query: 216 KLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQS 275
++K+ EKSE + LE E AS + E+ K+ QLE N +K
Sbjct: 1532 ---KVKKQLDHEKSELQTSLEEAE----ASLEHEEGKILRIQLELN---------QVKSE 1575
Query: 276 LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREK 335
++ I ++++ L K +H+ L+AE+++ ++++
Sbjct: 1576 IDRKIAEKDEELDQL----------KRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGD 1625
Query: 336 LQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQ 395
L + E+Q++ +Q E +L + ++K+ L L + D L+++
Sbjct: 1626 LNEMEIQLNHANRQAAEALRNLRNT-----QGILKDTQL---HLDDAIRGQDDLKEQLAM 1677
Query: 396 AERLVKQLEEEAKSRAEELKLLEEKLKGKEAEL----EKSSAAHTQATLLLQEKYDSMVQ 451
ER ++ E + L+ E K E EL E+ HTQ T L+ K +
Sbjct: 1678 VERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTK-----K 1732
Query: 452 SLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVR 511
LE +Q + E+ED+ E + +EKA KA +A + ++ + ++ R
Sbjct: 1733 KLETDISQIQG-------EMEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1785
Query: 512 M-------------LLDLQTKSALK--ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQL 556
M LD + ALK + +I+++ + ++++++ K E K L
Sbjct: 1786 MKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAV-KGL 1844
Query: 557 EDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ 616
E R E T E + I + + L ++L K K ++ Q A E E+Q+ +N
Sbjct: 1845 RKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQ--AEEAEEQSNVN------ 1896
Query: 617 EQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL-KSEVSKLRCQLAKKKQSETKLQE 675
L K R K++H ++ E + + +S+V+KLR K ++ TK+
Sbjct: 1897 --LAKFR--------------KLQHELEEAKERADIAESQVNKLR---VKSREVHTKVIS 1937
Query: 676 E 676
E
Sbjct: 1938 E 1938
Score = 68.2 bits (165), Expect = 3e-11
Identities = 90/435 (20%), Positives = 189/435 (43%), Gaps = 54/435 (12%)
Query: 22 GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKKESQ 79
G + LE +K + +KS+ +E++ +L ++ L +VKS +K ++
Sbjct: 1523 GGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAE 1582
Query: 80 KNDKDLKILEKEIRVLLQERGAQDRRIQD----------LETELEKMEARLNAALREKTS 129
K+++ ++ +RV+ + D I+ +E +L +ME +LN A R+
Sbjct: 1583 KDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAE 1642
Query: 130 LSANNATLEK-------QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKM 182
N + L + R + LK + + + NL + E+ +LR E
Sbjct: 1643 ALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANL--MQAEVEELRASLERTE 1700
Query: 183 RGM-MAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
RG MA+QE ++ +V T++ LE I+Q++G++ I +E ++
Sbjct: 1701 RGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQIQGEMEDIVQEA---RN 1754
Query: 230 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVED 289
EK + I + + +++++K + A LE K + L+ L+E + K +
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1814
Query: 290 LNVKCQLLEKEKEDHVNRNREHN----ENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 345
K + +E E V ++HN + L + +K+ +++R+ + + + +D
Sbjct: 1815 QIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1874
Query: 346 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 405
L + K EE ++ N+ + ++ EL++ +++ + AE V +L
Sbjct: 1875 LQTKVKAYKRQ--------AEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKL-- 1924
Query: 406 EAKSRAEELKLLEEK 420
KSR K++ E+
Sbjct: 1925 RVKSREVHTKVISEE 1939
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 122 bits (307), Expect = 9e-28
Identities = 172/744 (23%), Positives = 319/744 (42%), Gaps = 122/744 (16%)
Query: 40 KSQRFKQQKESKQNLNVDKDT-TLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
+S++ + K KQ ++ ++ L + + ++ + ++ ++ E + + L +E
Sbjct: 1128 ESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELK-KALEEE 1186
Query: 99 RGAQDRRIQDLE----TELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 154
+ +IQD+ T LE++ +L A R K +L N LE EL ++L+
Sbjct: 1187 TKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV 1246
Query: 155 FSENGNQKN------------------LRI-LSLELMKLRNK--------RETKMRGMMA 187
+E+ +++ LR+ L+ + KL+N+ E + +G+
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306
Query: 188 KQEG--MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCAS 245
++ +E +LQ TQ L+E + L ++ +E+EK L E EE A
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK-------NSLQEQQEEEEEAR 1359
Query: 246 DQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHV 305
+EK L + + K+K D+ L +SLEE L K E L+ + + EK
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLE----EKALAY 1415
Query: 306 NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK----- 360
++ + L E+ +L ++Q L++K+ + D LL +EK +S+ ++
Sbjct: 1416 DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 361 ------------LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAK 408
L EE ++ K FE + KQ +++ L ++ + V +LE+ +
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKR 1535
Query: 409 SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTA 468
+ ++++ + +L+ E EL+ + A + + +Q + L+ Q E K L
Sbjct: 1536 ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLI 1595
Query: 469 SEIEDL--KLENSSLQEKAAKAGK-----NAEDVQHQILATESSNQEYVRMLLDLQTKSA 521
++ +L +LE+ Q A A K + +D++ QI A + E ++ L LQ +
Sbjct: 1596 KQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMK 1655
Query: 522 LKETEIKEITVS----FLQ-------------KITDLQNQLKQQE------EDFRKQLED 558
+ E++E S F Q +I LQ +L E E R +L D
Sbjct: 1656 DYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELAD 1715
Query: 559 E-----EGRKA---EK---ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQA 607
E G+ A EK E A+L EE+ + + E L ++ + LQ+D E
Sbjct: 1716 EITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAE--- 1772
Query: 608 LLNEHGAAQEQLNKIRDSYAKLLGHQN--LKQKIKHV-----VKLKDENSQLKSEVSKLR 660
L E AAQ+ D+ + L QN LK K++ + K K S L++++ +L
Sbjct: 1773 LAAERSAAQKS-----DNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLE 1827
Query: 661 CQL---AKKKQSETKLQEELNKVL 681
QL AK++ + KL K L
Sbjct: 1828 EQLEQEAKERAAANKLVRRTEKKL 1851
Score = 108 bits (269), Expect = 2e-23
Identities = 140/660 (21%), Positives = 305/660 (46%), Gaps = 58/660 (8%)
Query: 39 QKSQRFKQQKESKQNLNVDK---DTTLPASARKVKSSESKKESQK----NDKDLKILEKE 91
++ +R QQ ++N+ ++ +T L A A ++++ + K+ + +D + ++ E+E
Sbjct: 876 EEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEE 935
Query: 92 IR--VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN- 148
R +L E+ IQDLE +L++ E EK + A +E++++ L N
Sbjct: 936 ERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNS 995
Query: 149 ------ELLKSKFSENGNQ-KNLRILSLELMKLRNKRETKMRGM---MAKQEGMEMKLQV 198
+L++ + +E +Q + L K+RNK+E + + + K+E +L+
Sbjct: 996 KFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK 1055
Query: 199 TQRSLE----ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISC----ASDQVEK 250
+R L+ + Q +IA+L+ ++ ++ + ++ E + L ++ + A V +
Sbjct: 1056 AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115
Query: 251 YKLDIAQLEENL---KEKNDEILSLKQSLEENIVILSKQVE---DLNVKCQLLEKEKEDH 304
+ IA+L+E+ K ++ K+ L E + L ++E D Q L ++E
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175
Query: 305 VNRNR----EHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
V + E +N A++Q+++Q+ +E + ++ + + L++ K+ + +++
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKE 1235
Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
L + + + K E + K+ ++ +L K + +RL +L E+A EL +
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
L +EAE + A A+L +S +Q +++ + K +S I L+ E +S
Sbjct: 1296 L--EEAEKKGIKFAKDAASL------ESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNS 1347
Query: 481 LQEKAAKAGKNAEDVQHQILATESSNQEYVRML-LDLQTKSALKETEIKEITVSFLQKIT 539
LQE+ + + ++++ Q+LA +S + + + DL T +L+E + +K+
Sbjct: 1348 LQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAK---------KKLL 1398
Query: 540 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 599
L Q+ E+ + E K + +LT +++ R + L K K F QL
Sbjct: 1399 KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFD-QLL 1457
Query: 600 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKL 659
A E A E E + +++ A L + L++ ++ + + +N QL++++ L
Sbjct: 1458 AEEKSISARYAEERDRAEAEAREKETKALSLA-RALEEALEAKEEFERQNKQLRADMEDL 1516
Score = 102 bits (255), Expect = 1e-21
Identities = 171/742 (23%), Positives = 318/742 (42%), Gaps = 125/742 (16%)
Query: 72 SESKKESQKNDKDL-KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSL 130
+ ++E Q D++L K+ EK+ +V E ELE+ME + L EK L
Sbjct: 848 TRQEEELQAKDEELLKVKEKQTKV---------------EGELEEMERKHQQLLEEKNIL 892
Query: 131 SAN--------------NATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRN 176
+ A L + EL L+S+ E ++ +IL E K++
Sbjct: 893 AEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEE--EEERNQILQNEKKKMQA 950
Query: 177 KRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLE 236
+ + + ++EG KLQ+ + + E KI ++E +++ +E + + K EK L
Sbjct: 951 HIQ-DLEEQLDEEEGARQKLQLEKVTAE---AKIKKMEEEILLLEDQ--NSKFIKEKKLM 1004
Query: 237 YIEEISCASDQVE-------------KYKLDIAQLEENLKEK---NDEILSLKQSLEENI 280
C+S E K ++ I+ LEE LK++ E+ K+ L+
Sbjct: 1005 EDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGET 1064
Query: 281 VILSKQVEDL-----NVKCQLLEKEKE------------DHVNRNREHNENLNAEMQNLK 323
L Q+ +L +K QL +KE+E H N + L A++ L+
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ 1124
Query: 324 QKFILEQQEREKLQQKELQIDSLLQQEK-ELSSSL-----HQKLCSFQEEMVKE-KNLFE 376
+ F E+ R K ++++ + L+ K EL +L Q+L + +E+ V E K E
Sbjct: 1125 EDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALE 1184
Query: 377 EELKQTLDELDKLQQKEEQA-ERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
EE K ++ ++Q+ A E L +QLE+ + +A LE+ +G E + K A
Sbjct: 1185 EETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKAN----LEKNKQGLETD-NKELACE 1239
Query: 436 TQATLLL-------QEKYDSMVQSLEDVTAQFESYKALTASEIEDL--KLEN-SSLQEKA 485
+ + ++K D+ VQ L ++ + + A + L +L+N S+L E+A
Sbjct: 1240 VKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEA 1299
Query: 486 AKAG----KNAEDVQHQILATESSNQEYVRMLLDL--------QTKSALKE--TEIKEIT 531
K G K+A ++ Q+ T+ QE R L+L + K++L+E E +E
Sbjct: 1300 EKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEAR 1359
Query: 532 VSFLQKITDLQNQL---KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELY 588
+ +++ LQ+QL K++ +D +E E K + L++ + + L Y++L
Sbjct: 1360 KNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLE 1419
Query: 589 NKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN------LKQKIKHV 642
Q +LD V+ L+ L K + + +LL + +++ +
Sbjct: 1420 KTKNRLQQELDDLTVD----LDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAE 1475
Query: 643 VKLKDENSQLKSEVSKLRCQLAKKKQSE---TKLQEELNKVLGIKHFDPSKAFHHESKEN 699
+ +++ ++ S L L K++ E +L+ ++ ++ K D K H K
Sbjct: 1476 AEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKD-DVGKNVHELEKSK 1534
Query: 700 FALKTPLKEGNTNCYRAPMECQ 721
AL+ ++E T E Q
Sbjct: 1535 RALEQQVEEMRTQLEELEDELQ 1556
Score = 81.3 bits (199), Expect = 3e-15
Identities = 101/462 (21%), Positives = 210/462 (45%), Gaps = 78/462 (16%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
S R+ ++++ + +K+T + AR ++ + E+K+E ++ +K L+ +
Sbjct: 1464 SARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDV 1523
Query: 89 EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAA----LREKTSLSANNATLEKQLIEL 144
K + L + + A +++++++ T+LE++E L A LR + ++ A A E+ L
Sbjct: 1524 GKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTR 1583
Query: 145 TRTNEL-----------LKSKFSENGNQKNLRILSLELMKLRNK-------RETKMRGMM 186
NE L+++ + Q+ L + S + M++ K K R +
Sbjct: 1584 DEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEV 1643
Query: 187 AKQ-EGMEMKLQVTQRSLEES---------------------QGKIAQLEGKLVSIEKEK 224
KQ ++ +++ QR LEE+ + +I QL+ +L S E+ +
Sbjct: 1644 IKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERAR 1703
Query: 225 IDEKSETEKLLEYIEEI----SCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENI 280
+ E ++L + I S D+ + + IAQLEE L+E+ + L +
Sbjct: 1704 RHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTT 1763
Query: 281 VILSKQVEDLNVK--CQLLEKEKEDHVNRNREH-NENLNAEMQNL----KQKFILEQQER 333
+ QV+ LN + + +K D+ + E N+ L A++Q L K KF +
Sbjct: 1764 L----QVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKF---KATI 1816
Query: 334 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKE 393
L+ K Q++ L+QE + ++ + KL E+ +KE + E+ ++ D+ +++
Sbjct: 1817 SALEAKIGQLEEQLEQEAKERAAAN-KLVRRTEKKLKEIFMQVEDERR---HADQYKEQM 1872
Query: 394 EQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
E+A +KQL+ + + EE + + EL+ ++ A+
Sbjct: 1873 EKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEAN 1914
Score = 73.6 bits (179), Expect = 6e-13
Identities = 100/410 (24%), Positives = 174/410 (42%), Gaps = 49/410 (11%)
Query: 283 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ---EREKLQQK 339
+++Q E+L K + L K KE E E Q L++K IL +Q E E +
Sbjct: 847 VTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEA 906
Query: 340 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399
E L +++EL LH E V+E EEE Q L K Q Q L
Sbjct: 907 EEMRARLAAKKQELEEILHDL-----ESRVEE----EEERNQILQNEKKKMQAHIQD--L 955
Query: 400 VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 459
+QL+EE +R ++ +LEK +A +A + +K + + LED ++
Sbjct: 956 EEQLDEEEGAR-------------QKLQLEKVTA---EAKI---KKMEEEILLLEDQNSK 996
Query: 460 FESYKALTASEIEDLKLENSSLQEKAAKAGK--NAEDVQHQILATESSNQEYVRMLLDLQ 517
F K L I + + + +EKA K N ++V L +E R L+
Sbjct: 997 FIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA 1056
Query: 518 TKSALKETEIKEITVSFLQ-KITDLQNQLKQQEEDFRKQLEDEEGRKAEKENT------- 569
+ ET + ++ LQ +I +L+ QL ++EE+ + L + K N
Sbjct: 1057 KRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVREL 1116
Query: 570 ---TAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 626
AEL E+ + + + + +L+A + E + L+ A QE K
Sbjct: 1117 QAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176
Query: 627 AKLLGHQNLKQKIK-HVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
A+L + L+++ K H +++D + + + +L QL + K+ + L++
Sbjct: 1177 AEL--KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK 1224
Score = 70.9 bits (172), Expect = 4e-12
Identities = 82/400 (20%), Positives = 178/400 (44%), Gaps = 41/400 (10%)
Query: 333 REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF-----EEELKQTLDELD 387
R+ +K+ Q+ +L ++ ++ L + + K K L EEEL+ +EL
Sbjct: 803 RKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEELQAKDEELL 862
Query: 388 KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLK------GKEAELEKSSAAHTQATLL 441
K+++K+ + E ++++E + + EE +L E+L+ + E+ AA Q
Sbjct: 863 KVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEE 922
Query: 442 LQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLE-------NSSLQEKAAKAGKNAED 494
+ +S V+ E+ ++ K + I+DL+ + LQ + A +
Sbjct: 923 ILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKK 982
Query: 495 VQHQILATESSNQEYV--RMLLD---LQTKSALKETEIKEITVSFLQK-----ITDLQNQ 544
++ +IL E N +++ + L++ + S L E E K ++ ++ I+DL+ +
Sbjct: 983 MEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042
Query: 545 LKQQE---EDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF 601
LK++E ++ K +G + ++ AEL +I++ +L + + + + D
Sbjct: 1043 LKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDE 1102
Query: 602 EVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRC 661
+ K L Q Q+ ++++ + +N +K K L +E LK+E+
Sbjct: 1103 TLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKR--DLSEELEALKTELEDTLD 1160
Query: 662 QLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFA 701
A +++ TK ++E+ ++ KA E+K + A
Sbjct: 1161 TTAAQQELRTKREQEVAEL--------KKALEEETKNHEA 1192
Score = 69.7 bits (169), Expect = 9e-12
Identities = 84/403 (20%), Positives = 174/403 (43%), Gaps = 27/403 (6%)
Query: 48 KESKQNLNVDKDTTLPASARKVKSSESKKESQKN--DKDLKILEKEIRVLLQERGAQDRR 105
+++K L V+ R +++ + + E +K K ++ LE E+ ++R
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVAS 1618
Query: 106 IQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE-----NGN 160
+ +E +L+ +EA++ AA + + + L+ Q+ + R E ++ E +
Sbjct: 1619 KKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKES 1678
Query: 161 QKNLRILSLELMKLRNKRETKMRGMM-AKQEGMEMKLQVTQRSLEESQ--GKIAQLEGKL 217
+K L+ L E+++L+ + + R A+QE E+ ++T + +S + +LE ++
Sbjct: 1679 EKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARI 1738
Query: 218 VSIEKEKIDEKSETEKLLEYIEEISCASDQVEKY---KLDIAQLEEN----LKEKNDEIL 270
+E+E +E+S E L + + + D + + AQ +N L+ +N E+
Sbjct: 1739 AQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELK 1798
Query: 271 SLKQSLEENIVILSKQ-VEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 329
+ Q LE + K + L K LE++ E N+ + + LK+ F+
Sbjct: 1799 AKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQV 1858
Query: 330 QQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKL 389
+ ER Q + Q++ + K+L L + EE N +L++ ELD
Sbjct: 1859 EDERRHADQYKEQMEKANARMKQLKRQLEE-----AEEEATRANASRRKLQR---ELDDA 1910
Query: 390 QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS 432
+ E R V L+ + R + + ++ LE +S
Sbjct: 1911 TEANEGLSREVSTLKNRLR-RGGPISFSSSRSGRRQLHLEGAS 1952
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 122 bits (305), Expect = 2e-27
Identities = 134/550 (24%), Positives = 258/550 (46%), Gaps = 58/550 (10%)
Query: 172 MKLRNKRETKMRGMMAKQEGMEMKLQV--TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
MKL K + ++ ++E MK + + +LE+S+ + +LE K+VS+ +EK D +
Sbjct: 832 MKLYFKIKPLLKSAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQL 891
Query: 230 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND----------EILSLKQSLEEN 279
+ + + + + DQ+ K K+ QLE +KE N+ E+ + K+ LE+
Sbjct: 892 QVQAEQDNLNDAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 948
Query: 280 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 339
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 949 CSELKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDEIIAKLTKEKKALQEA 1004
Query: 340 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399
Q LQ E++ +SL + ++++ + E+E K +D L++ + + E
Sbjct: 1005 HQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMD----LERAKRKLEGD 1060
Query: 400 VKQLEEEAKSRAEELKLLEEKLKGKEAEL-EKSSAAHTQATLLLQ-----EKYDSMVQSL 453
+K +E + LEEKLK KE ++ +++S + L LQ ++ + ++ L
Sbjct: 1061 LKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEEL 1120
Query: 454 EDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRML 513
E+ + +A DL E + E+ +AG A V QI + E+ +M
Sbjct: 1121 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAG-GATSV--QIEMNKKREAEFQKMR 1177
Query: 514 LDLQ--------TKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEGR 562
DL+ T +AL++ + ++I +LQ +L++++ +F+ +L+D
Sbjct: 1178 RDLEEATLQHEATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSN 1236
Query: 563 -------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL---LNEH 612
KA E + L ++ N++R+ EE F Q + E L L E
Sbjct: 1237 MEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEEK 1296
Query: 613 GAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK-QSET 671
A QL + + SY + + ++LK++++ K K+ + + ++ C L +++ + ET
Sbjct: 1297 EALISQLTRGKLSYTQQM--EDLKRQLEEEGKAKNALAH-ALQSARHDCDLLREQYEEET 1353
Query: 672 KLQEELNKVL 681
+ + EL +VL
Sbjct: 1354 EAKAELQRVL 1363
Score = 114 bits (286), Expect = 2e-25
Identities = 160/723 (22%), Positives = 302/723 (41%), Gaps = 102/723 (14%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQER 99
K Q + KE + L +++ +A+K K + E +K+ DL++ ++ +E+
Sbjct: 914 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE---KEK 970
Query: 100 GAQDRRIQDLETELEKMEARLNAALREKTSLS-ANNATLEKQLIELTRTNELLKSKFS-- 156
A + ++++L E+ ++ + +EK +L A+ L+ +E + N L KSK
Sbjct: 971 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLE 1030
Query: 157 --------------------ENGNQK---NLRILSLELMKLRN----------KRETKMR 183
E +K +L++ +M L N K+E +
Sbjct: 1031 QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDIN 1090
Query: 184 GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLE 236
+K E ++ Q+ L+E+Q +I +LE +L +EK + D E E++ E
Sbjct: 1091 QQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE 1150
Query: 237 YIEEISCASD-QVEKYKLDIAQLEENLKEKNDEIL-------SLKQSLEENIVILSKQVE 288
+EE A+ Q+E K A+ ++ ++ + L +L++ +++ L +Q++
Sbjct: 1151 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID 1210
Query: 289 DLNVKCQLLEKEKE------DHVNRNREHNENLNAEMQNLKQKFILEQQ----------- 331
+L Q LEKEK D V N E A ++ + + LE Q
Sbjct: 1211 NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRT--LEDQANEYRVKLEEA 1268
Query: 332 ---------EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 382
+R KLQ + ++ L++++ L S L + S+ ++M K EEE K
Sbjct: 1269 QRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAK 1328
Query: 383 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 442
LQ + L +Q EEE +++AE ++L + K Q T L
Sbjct: 1329 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL 1388
Query: 443 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 502
+E + Q L+D E+ A +S L+ LQ + + E A
Sbjct: 1389 EEAKKKLAQRLQDAEEAVEAVNAKCSS----LEKTKHRLQNEIEDLMVDVERSNAAAAAL 1444
Query: 503 ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 562
+ + + ++L + + K ++E++ S ++ L +L + + + + LE E
Sbjct: 1445 DKKQRNFDKILAEWKQKYEESQSELE----SSQKEARSLSTELFKLKNAYEESLEHLETF 1500
Query: 563 KAEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE-Q 618
K E +N E LTE++ + EL K QL+ ++E Q+ L E A+ E +
Sbjct: 1501 KRENKNLQEEISDLTEQLGEGGKNVHELEKVRK----QLEVEKLELQSALEEAEASLEHE 1556
Query: 619 LNKIRDSYAKLLGHQNLKQKIKHVVKLKDEN-SQLKSEVSKLRCQLAKKKQSETKLQEEL 677
KI + L +K +I+ + KDE Q K ++ L +ET+ + E+
Sbjct: 1557 EGKILRAQ---LEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEV 1613
Query: 678 NKV 680
+V
Sbjct: 1614 LRV 1616
Score = 110 bits (275), Expect = 5e-24
Identities = 142/690 (20%), Positives = 300/690 (43%), Gaps = 89/690 (12%)
Query: 89 EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL-TRT 147
EKE+ + +E G ++ E +++E ++ + L+EK L + L + R
Sbjct: 848 EKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERC 907
Query: 148 NELLKSKFSENGNQKNL-------RILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQ 200
++L+K+K K + ++ EL + K E + + + +E+ L +
Sbjct: 908 DQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVE 967
Query: 201 RSLEESQGKIAQLEGKLVSIE----KEKIDEKSETEKLLEYIEEISCASDQV-----EKY 251
+ ++ K+ L ++ ++ K ++K+ E + ++++ D+V K
Sbjct: 968 KEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKV 1027
Query: 252 KLD--IAQLEENLKEKNDEILSL---KQSLEENIVILSKQVEDL-NVKCQLLEKEKEDHV 305
KL+ + LE +L+++ + L K+ LE ++ + + + DL N K QL EK K+
Sbjct: 1028 KLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEF 1087
Query: 306 NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ 365
+ N+++++ ++ + +L Q ++KL++ + +I+ L++E E + K+ +
Sbjct: 1088 DINQQNSK--------IEDEQVLALQLQKKLKENQARIEE-LEEELEAERTARAKVEKLR 1138
Query: 366 EEMVKEKNLFEEELKQ----TLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKL 421
++ +E E L++ T +++ +++E + +++ + LEE L +K
Sbjct: 1139 SDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKH 1198
Query: 422 KGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY---KALTASEIEDLKLEN 478
AEL + + L+++ L+DVT+ E KA L+ +
Sbjct: 1199 ADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQA 1258
Query: 479 SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEIT---VSFL 535
+ + K +A ++ D Q ++ N E R L + KE I ++T +S+
Sbjct: 1259 NEYRVKLEEAQRSLNDFTTQRAKLQTENGELARQLEE-------KEALISQLTRGKLSYT 1311
Query: 536 QKITDLQNQLKQQEED-----------------FRKQLEDEEGRKAEKENTTAELTEEIN 578
Q++ DL+ QL+++ + R+Q E+E KAE + ++ E+
Sbjct: 1312 QQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVA 1371
Query: 579 KWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK 638
+WR YE T Q + + E K+ L A+E + + + L +K
Sbjct: 1372 QWRTKYE-----TDAIQ-RTEELEEAKKKLAQRLQDAEEAVEAVNAKCSSL-------EK 1418
Query: 639 IKHVVKLKDENSQLKSEVSKLRCQLA---KKKQSETKLQEELNKVLGIKHFDPSKAFHHE 695
KH +L++E L +V + A KK+++ K+ E + K+ +
Sbjct: 1419 TKH--RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ----KYEESQSELESS 1472
Query: 696 SKENFALKTPLKEGNTNCYRAPMECQESWK 725
KE +L T L + N Y +E E++K
Sbjct: 1473 QKEARSLSTELFK-LKNAYEESLEHLETFK 1501
Score = 105 bits (263), Expect = 1e-22
Identities = 152/687 (22%), Positives = 313/687 (45%), Gaps = 74/687 (10%)
Query: 42 QRFKQQKESKQN---LNVDKDTTLPASARKVKSSESKK----ESQKNDKDLKILE--KEI 92
QR KQ+ E +++ L +D T+ K K++ K E Q N+ +K+ E + +
Sbjct: 1213 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSL 1272
Query: 93 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
+R +L +LE+ EA ++ R K S + L++QL E +
Sbjct: 1273 NDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALA 1332
Query: 149 ----------ELLKSKFSENGNQKN--LRILSL---ELMKLRNKRETKMRGMMAKQEGME 193
+LL+ ++ E K R+LS E+ + R K ET + +E E
Sbjct: 1333 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD--AIQRTEELEE 1390
Query: 194 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
K ++ QR L++++ + + K S+EK K ++E E L+ +E + A+ ++K +
Sbjct: 1391 AKKKLAQR-LQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1449
Query: 254 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
+ ++ K+K +E S +S ++ LS ++ K + +E +H+ + N+
Sbjct: 1450 NFDKILAEWKQKYEESQSELESSQKEARSLSTEL----FKLKNAYEESLEHLETFKRENK 1505
Query: 314 NLNAEMQNLKQ------KFILEQQE-REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE 366
NL E+ +L + K + E ++ R++L+ ++L++ S L++ + K+ Q
Sbjct: 1506 NLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQL 1565
Query: 367 EMVKEKNLFEEELKQTLDELDKLQQKEEQ-AERLVKQLEEEAKSRAEELKLLEEKLKGKE 425
E + K E +L + +E+++ ++ ++ + L L+ E +SR E L+ +++K++G
Sbjct: 1566 EFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLR-VKKKMEGDL 1624
Query: 426 AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKA 485
E+E + + Q++ S+ L+D Q + A+ A+ +DLK + ++ +
Sbjct: 1625 NEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDD--AVRAN--DDLKENIAIVERRN 1680
Query: 486 AKAGKNAEDVQHQILATESS----NQEYVR-----MLLDLQTKSALKETEIKEITVSFLQ 536
E+++ + TE S QE + LL Q S + + + E ++ LQ
Sbjct: 1681 NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQ 1740
Query: 537 -KITDLQNQLKQQEEDFRKQLEDEE--GRKAEKENTTAELTEEINKWRLLYEELYNKTKP 593
++ + + + EE +K + D + +KE T+ E + K + K
Sbjct: 1741 SEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK------NMEQTIKD 1794
Query: 594 FQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLK 653
Q +LD E E+ AL ++QL K+ +L G +QK ++ +K +
Sbjct: 1795 LQHRLD--EAEQIAL----KGGKKQLQKLEARVRELEGELEAEQK-RNAESVKGMRKS-E 1846
Query: 654 SEVSKLRCQLAKKKQSETKLQEELNKV 680
+ +L Q + K++ +LQ+ ++K+
Sbjct: 1847 RRIKELTYQTEEDKKNLLRLQDLVDKL 1873
Score = 73.9 bits (180), Expect = 5e-13
Identities = 90/453 (19%), Positives = 200/453 (44%), Gaps = 59/453 (13%)
Query: 37 SFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLL 96
S + + FK++ ++ Q D L + V E +K K L++ + E++ L
Sbjct: 1493 SLEHLETFKRENKNLQEEISDLTEQLGEGGKNVH------ELEKVRKQLEVEKLELQSAL 1546
Query: 97 QERGA----QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRT----- 147
+E A ++ +I + E +++A + L EK +++++ +T
Sbjct: 1547 EEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAE 1606
Query: 148 ----NELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQ-EGMEMKLQVTQRS 202
NE+L+ K G+ L M+++ +M KQ + ++ L+ TQ
Sbjct: 1607 TRSRNEVLRVKKKMEGD--------LNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQ 1658
Query: 203 LEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENL 262
L+++ L+ + +E+ ++E E+L +E+ + E+ ++ ++ + L
Sbjct: 1659 LDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLL 1718
Query: 263 KEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHN 312
+N +++ K+ +E ++ L +VE+ +C+ E++ + + + + ++ +
Sbjct: 1719 HSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTS 1778
Query: 313 ENLNAEMQNLKQ-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ-------- 359
+L +N++Q + L++ E+ L+ + Q+ L + +EL L
Sbjct: 1779 AHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAES 1838
Query: 360 -KLCSFQEEMVKEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEEL 414
K E +KE EE K+ L D +DKLQ K + +R ++ EE+A + +
Sbjct: 1839 VKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF 1898
Query: 415 KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 447
+ ++ +L EAE E++ A +Q L + D
Sbjct: 1899 RKVQHEL--DEAE-ERADIAESQVNKLRAKSRD 1928
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 120 bits (302), Expect = 3e-27
Identities = 158/752 (21%), Positives = 324/752 (43%), Gaps = 121/752 (16%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQK--NDKDLKILEKEIRV--L 95
+SQ ++ + ++ L + + A + + + K+E ++ +D + ++ E+E R L
Sbjct: 875 QSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHL 934
Query: 96 LQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRTN 148
E+ + IQ+LE +LE+ E+ EK + A LE++ I +L +
Sbjct: 935 QAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEK 994
Query: 149 ELLKSKFSE-NGNQKNLRILSLELMKLRNKRE---TKMRGMMAKQEGMEMKLQVTQRSLE 204
+LL+ + +E N S L KL+NK E T + + ++E +L+ T+R LE
Sbjct: 995 KLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLE 1054
Query: 205 -----------ESQGKIAQLEGKLVSIEKE------KIDE---------------KSETE 232
E Q +IA+L+ +L E+E +++E +S+
Sbjct: 1055 GDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQIS 1114
Query: 233 KLLEYIEEISCASDQVEKYKLDIAQLEENLK------------------EKNDEILSLKQ 274
+L E +E + ++ EK K D+ + E LK ++ E+ LK+
Sbjct: 1115 ELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKK 1174
Query: 275 SLEENIVILSKQVEDLNVK-------------------------CQLLEKEKEDHVNR-- 307
+LEE Q++++ K Q LE E+ + N
Sbjct: 1175 TLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVK 1234
Query: 308 -------NREH-NENLNAEMQNLKQKFILEQQEREKLQQK--ELQID-----SLLQQEKE 352
+ EH + + A++Q L+ KF ++ R +L K +LQ++ LL Q
Sbjct: 1235 VLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDS 1294
Query: 353 LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSR-- 410
SS L + + + ++ + L +EE +Q L KL+Q E++ +QLEEE +++
Sbjct: 1295 KSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHN 1354
Query: 411 -AEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQEKYDSMVQSLEDVTAQF---ESY 463
+++ L ++ + ++E S A + LQ+ + + Q E+ A + E
Sbjct: 1355 LEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKT 1414
Query: 464 KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 523
K E++DL ++ ++ A K + + ++ + +Y + ++ K
Sbjct: 1415 KTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474
Query: 524 ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 583
ET+ + + L++ + + +L++ + FR ++ED K + + EL +
Sbjct: 1475 ETKALSLARA-LEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Query: 584 YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVV 643
EE+ + + + +L A E K L A + Q RD + Q+ ++K + V
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE--RDLQGR--DEQSEEKKKQLVR 1589
Query: 644 KLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
++++ ++L+ E + +A +K+ E L++
Sbjct: 1590 QVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621
Score = 118 bits (296), Expect = 2e-26
Identities = 137/681 (20%), Positives = 310/681 (45%), Gaps = 63/681 (9%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKILEKEIRVLLQERGAQDR 104
Q+ K + V++ ++VK++ E K++ +N++ L E++VLLQ +G +
Sbjct: 1188 QEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE--LANEVKVLLQGKGDSEH 1245
Query: 105 RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGN-QKN 163
+ + +E +L++++ + N R +T L+ L+ +EL LL S++ K+
Sbjct: 1246 KRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ---VELDNVTGLLSQSDSKSSKLTKD 1302
Query: 164 LRILSLELM---KLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSI 220
L +L +L + + + K + +E + + LEE + LE ++ ++
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL 1362
Query: 221 EKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENI 280
+ D K + E + + C + E+ K + + E L ++++E ++ LE+
Sbjct: 1363 HAQVADMKKKME------DSVGCL-ETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTK 1415
Query: 281 VILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQERE----KL 336
L ++++DL V +++ ++ + ++ + L AE + + K+ E+ E +
Sbjct: 1416 TRLQQELDDLLVDLDH-QRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREK 1474
Query: 337 QQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK----LQQK 392
+ K L + L++ E + L + F+ EM ++ ++++ +++ EL+K L+Q+
Sbjct: 1475 ETKALSLARALEEAMEQKAELERLNKQFRTEM-EDLMSSKDDVGKSVHELEKSKRALEQQ 1533
Query: 393 EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQS 452
E+ + +++LE+E ++ + LE L+ +A+ E+ + + +EK +V+
Sbjct: 1534 VEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQS---EEKKKQLVRQ 1590
Query: 453 LEDVTAQFE---SYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEY 509
+ ++ A+ E +++ + + L+++ L+ A KN ++ Q+ ++ ++
Sbjct: 1591 VREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDC 1650
Query: 510 VRMLLD---------LQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEE 560
+R L D Q K K+ + E + LQ+ + K+Q + R +L DE
Sbjct: 1651 MRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI 1710
Query: 561 GRKAEK-----------ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVE----- 604
+ K E A+L EE+ + + E + ++ K LQ+D +
Sbjct: 1711 ANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLER 1770
Query: 605 KQALLNEHGAAQ-EQLNK-IRDSYAKLLGHQNLKQKIKHV---VKLKDENSQLKSEVSKL 659
A NE+ Q E+ NK ++ ++ G K K K+ QL +E +
Sbjct: 1771 SHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKER 1830
Query: 660 RCQLAKKKQSETKLQEELNKV 680
+ + +++E KL++ L +V
Sbjct: 1831 QAACKQVRRTEKKLKDVLLQV 1851
Score = 95.5 bits (236), Expect = 2e-19
Identities = 109/547 (19%), Positives = 245/547 (44%), Gaps = 49/547 (8%)
Query: 196 LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDI 255
LQV+++ EE K E +LV + ++++ ++ ++ ++ Q+++
Sbjct: 838 LQVSRQE-EEMMAK----EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAE 892
Query: 256 AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 315
+L +E + + KQ LEE L +VE+ +CQ L+ EK+ +
Sbjct: 893 TELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK-----------KM 941
Query: 316 NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 375
+Q L+++ E+ R+KLQ +++ ++ L++ +E L + C ++ KEK L
Sbjct: 942 QQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNC----KLAKEKKLL 997
Query: 376 EEELKQTLDELDKLQQK-------EEQAERLVKQLEEEAK---SRAEELKLLEEKLKGKE 425
E+ + + L + ++K + + E ++ LEE + + +EL+ KL+G
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS 1057
Query: 426 AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFE---SYKALTASEIEDLKLENSSLQ 482
+L A L+ + + L+ A+ E + K + +I +L+ + S LQ
Sbjct: 1058 TDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQ 1117
Query: 483 E--KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
E ++ +A +N + Q + L E E ++ L+ S + E++ Q++
Sbjct: 1118 EDLESERASRNKAEKQKRDLGEE---LEALKTELEDTLDSTAAQQELRS---KREQEVNI 1171
Query: 541 LQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDA 600
L+ L+++ + Q+++ + + EL E++ + + + L + + +
Sbjct: 1172 LKKTLEEEAKTHEAQIQE---MRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGE 1228
Query: 601 FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLR 660
E + LL G ++ + K+ +L N ++++ +L D+ ++L+ E+ +
Sbjct: 1229 LANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVR--TELADKVTKLQVELDNVT 1286
Query: 661 CQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLK--EGNTNCYRAPM 718
L++ +KL ++ + L + D + E+++ +L T LK E N +R +
Sbjct: 1287 GLLSQSDSKSSKLTKDFS-ALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQL 1345
Query: 719 ECQESWK 725
E +E K
Sbjct: 1346 EEEEEAK 1352
Score = 92.0 bits (227), Expect = 2e-18
Identities = 122/546 (22%), Positives = 251/546 (45%), Gaps = 86/546 (15%)
Query: 185 MMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEK--SETEKLLEYIE--- 239
MMAK+E + +K++ Q + E ++ L+ +L++ EK ++ E+ +ETE E E
Sbjct: 847 MMAKEEEL-VKVREKQLAAENRLTEMETLQSQLMA-EKLQLQEQLQAETELCAEAEELRA 904
Query: 240 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 299
++ ++E+ D+ E +E+ + + K+ +++NI L +Q+E+ Q L+
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQL 964
Query: 300 EK-EDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL- 357
EK + E + E QN K +E++ L+ + + + L +E+E S SL
Sbjct: 965 EKVTTEAKLKKLEEEQIILEDQNCKL-----AKEKKLLEDRIAEFTTNLTEEEEKSKSLA 1019
Query: 358 -----HQKLCSFQEEMVKEKNLFEEELKQTLDELD----------------------KLQ 390
H+ + + EE ++ + +EL++T +L+ +L
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079
Query: 391 QKEEQAERLVKQLEEEAKSR---AEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQE 444
+KEE+ + + ++EEEA + ++++ LE ++ + +LE A+ +A L E
Sbjct: 1080 KKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGE 1139
Query: 445 KYDSMVQSLEDV---TAQFESYKALTASEI--------EDLKLENSSLQEKAAKAGKNAE 493
+ +++ LED TA + ++ E+ E+ K + +QE K + E
Sbjct: 1140 ELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE 1199
Query: 494 DVQHQILATE--SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEED 551
++ Q+ T+ +N E + L+ + E ++ LQ D +++ K+ E
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKV------LLQGKGDSEHKRKKVE-- 1251
Query: 552 FRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNE 611
QL++ + + E E EL +++ K L EL N T L + + L +
Sbjct: 1252 --AQLQELQVKFNEGERVRTELADKVTK---LQVELDNVTG----LLSQSDSKSSKLTKD 1302
Query: 612 HGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSET 671
A + QL ++ LL +N +QK+ KLK Q++ E + R QL ++++++
Sbjct: 1303 FSALESQLQDTQE----LLQEEN-RQKLSLSTKLK----QVEDEKNSFREQLEEEEEAKH 1353
Query: 672 KLQEEL 677
L++++
Sbjct: 1354 NLEKQI 1359
Score = 70.9 bits (172), Expect = 4e-12
Identities = 110/589 (18%), Positives = 247/589 (41%), Gaps = 65/589 (11%)
Query: 9 KRFNDPSGCAPSPGAYDVKTLEVLKGPVSF--QKSQRFKQQKESKQNLNVDKDTTLPASA 66
K+ D GC + K + L+G +K + + +++K L + D L
Sbjct: 1371 KKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLD 1430
Query: 67 RKVKSSESKKESQKNDKDLKILEKEIRV-LLQERGAQDRRIQDLETELEKMEARLNAALR 125
+ +S+ + ++ QK L EK I +ER + ++ ET+ + L A+
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490
Query: 126 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 185
+K L N ++ +L + + + E +K+ R L ++ +++ + E +
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDVGKSVHEL--EKSKRALEQQVEEMKTQLEELEDEL 1548
Query: 186 MAKQEG---MEMKLQVTQRSLEES-QGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEI 241
A ++ +E+ LQ + E QG+ Q E K + ++ + ++E E + ++
Sbjct: 1549 QATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELE---DERKQR 1605
Query: 242 SCASDQVEKYKLDIAQLEENLKEKN---DEILSLKQSLEENIVILSKQVEDLNV-KCQLL 297
S A +K ++D+ LE ++ N DE + + L+ + ++++D + ++L
Sbjct: 1606 SMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEIL 1665
Query: 298 EKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSL 357
+ KE N + +++ AEM L+++ ++ + + QQ+ ++ E+++S
Sbjct: 1666 AQAKE-----NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELAD------EIANSS 1714
Query: 358 HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 417
+ + +E K E + Q +EL++ Q E +K+ + +L L
Sbjct: 1715 GKGALALEE-----KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1769
Query: 418 EEKLKGKEAELEKSSAAHTQATLLLQE-------KYDSMVQSLEDVTAQFESYKALTASE 470
+ E ++ + + + LQE KY + + +LE AQ E +
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLE-------EQ 1822
Query: 471 IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI 530
+++ E + ++ + K +DV Q+ + ++Y K+ K
Sbjct: 1823 LDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQY-------------KDQADKAS 1869
Query: 531 TVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK 579
T ++ L+ QL++ EE+ ++ + E E+ T E + +N+
Sbjct: 1870 T-----RLKQLKRQLEEAEEEAQRANASRRKLQRELEDAT-ETADAMNR 1912
Score = 68.2 bits (165), Expect = 3e-11
Identities = 85/465 (18%), Positives = 203/465 (43%), Gaps = 82/465 (17%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
S ++ ++++ + +K+T + AR ++ + E K E ++ +K + +
Sbjct: 1457 SAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDV 1516
Query: 89 EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAA----LREKTSLSANNATLEKQLI-- 142
K + L + + A ++++++++T+LE++E L A LR + +L A A E+ L
Sbjct: 1517 GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGR 1576
Query: 143 ---------ELTRTNELLKSKFSENGNQKNLRILSL----------------------EL 171
+L R ++++ + Q+++ + + E
Sbjct: 1577 DEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEA 1636
Query: 172 MKLRNKRETKMRGMM-------AKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEK 224
+K K + +M+ M A +E + + + ++ L+ + ++ QL+ +L + E+ K
Sbjct: 1637 IKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAK 1696
Query: 225 IDEKSETEKLLEYIEEIS----CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENI 280
+ E ++L + I S A ++ + + IAQLEE L+E+ + L++
Sbjct: 1697 RQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKAN 1756
Query: 281 VILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNL----KQKFI--------- 327
+ + + DLN++ +K + R+ N+ L ++Q + K K+
Sbjct: 1757 LQIDQINTDLNLERSHAQKNENARQQLERQ-NKELKVKLQEMEGTVKSKYKASITALEAK 1815
Query: 328 ---LEQQEREKLQQKELQIDSLLQQEKELSSSLHQ-----KLCSFQEEMVKEKNLFEEEL 379
LE+Q + ++++ + + EK+L L Q + ++ + + ++L
Sbjct: 1816 IAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQL 1875
Query: 380 KQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 424
K+ L+E ++ Q+ + R +++ E+A A+ + LK K
Sbjct: 1876 KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNK 1920
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 119 bits (298), Expect = 1e-26
Identities = 126/549 (22%), Positives = 257/549 (46%), Gaps = 56/549 (10%)
Query: 172 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKID--- 226
MKL K + ++ ++E MK Q T+ L +S+ K +LE KLV++ +EK D
Sbjct: 831 MKLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQL 890
Query: 227 -EKSETEKLL---EYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 282
++E+E LL E +++ A Q+E ++ + E+ +E N E+ + K+ LE+
Sbjct: 891 QVQAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 950
Query: 283 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 342
L K ++DL + +EKEK H N+ +NL E+ L + +E++ LQ+ Q
Sbjct: 951 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEELSGLDETIAKLTREKKALQEAHQQ 1006
Query: 343 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 402
LQ E++ +SL++ ++++ ++ E+E K +D L++ + + E +K
Sbjct: 1007 ALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVD----LERNKRKLEGDLKL 1062
Query: 403 LEEEAKSRAEELKLLEEKLKGKEAE-LEKSSAAHTQATLLLQ-----EKYDSMVQSLEDV 456
+E + + L+E+LK K+ E + S + TL LQ ++ + ++ LE+
Sbjct: 1063 AQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEE 1122
Query: 457 TAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 516
+ +A T + D E L E+ +AG QI + E++++ DL
Sbjct: 1123 IEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST---QIELNKKREAEFLKLRRDL 1179
Query: 517 QTKSALKETEIKEITVSFLQKITDLQNQ----------LKQQEEDFRKQLEDEEG----- 561
+ + E + + + +L Q L++++ +F+ +++D
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239
Query: 562 --RKAEKENTTAELTEEINKWRLLYEELYNK-----TKPFQLQLDAFEVEKQALLNEHGA 614
KA E L +++++ R EE+ T+ +LQ +A E+ +Q L E +
Sbjct: 1240 SKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQ--LEEKES 1297
Query: 615 AQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSEVSKLRCQLAKKKQSE 670
QL++ + ++ + + LK++++ K K+ + + + LR Q ++++ +
Sbjct: 1298 IVSQLSRSKQAFTQQT--EELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355
Query: 671 TKLQEELNK 679
+LQ L+K
Sbjct: 1356 AELQRALSK 1364
Score = 110 bits (276), Expect = 4e-24
Identities = 158/717 (22%), Positives = 321/717 (44%), Gaps = 82/717 (11%)
Query: 42 QRFKQQKESKQN---LNVDKDTTLPASARKVKSSESKKESQKNDK--DLKILEKEIRVLL 96
QR KQ+ E +++ L +D ++ S K K++ K D+ + + +EI+ L
Sbjct: 1212 QRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL 1271
Query: 97 QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
E Q R+Q +L +LE+ E+ ++ R K + + L++QL E +
Sbjct: 1272 SELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALA 1331
Query: 149 ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 193
+LL+ ++ E Q+ L + E+ + R K ET + +E E
Sbjct: 1332 HALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETD--AIQRTEELEE 1389
Query: 194 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
K ++ QR L++S+ ++ + K S+EK K + E E L+ +E + + ++K +
Sbjct: 1390 AKKKLAQR-LQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQR 1448
Query: 254 DIAQLEENLKEKNDEILS-LKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN 312
+ ++ K K +E + L+ SL+E S+ + K + +E D + + N
Sbjct: 1449 NFDKVLAEWKTKCEESQAELEASLKE-----SRSLSTELFKLKNAYEEALDQLETVKREN 1503
Query: 313 ENLNAEMQNLKQ------KFILE-QQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ 365
+NL E+ +L + K I E ++ R++++ ++ I L++ + K+ Q
Sbjct: 1504 KNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Query: 366 EEMVKEKNLFEEELKQTLDELDKLQQKEEQA-ERLVKQLEEEAKSRAEELKLLEEKLKGK 424
E+ + K+ + ++ + +E+++L++ ++ E + L+ E +SR E ++L ++K++G
Sbjct: 1564 LELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRL-KKKMEGD 1622
Query: 425 EAELE-KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQE 483
E+E + S A+ QA L+ S+ L+D + AL E DLK + + ++
Sbjct: 1623 LNEIEIQLSHANRQAAETLKH-LRSVQGQLKDTQLHLDD--ALRGQE--DLKEQLAIVER 1677
Query: 484 KAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN 543
+A E+++ + TE + + + LLD + L T+ + + + TDL
Sbjct: 1678 RANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLM- 1736
Query: 544 QLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTKPFQL 596
QL+ + ED + + E + + A + EE+ K + + L K Q
Sbjct: 1737 QLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH 1796
Query: 597 QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-----------NLKQKIKHVVKL 645
+LD E E+ AL Q+ +IR+ +L G Q ++++K +
Sbjct: 1797 RLD--EAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQ 1854
Query: 646 KDENS----QLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKE 698
+E+ +L+ V KL+ ++ K+ + E+ N H + HE +E
Sbjct: 1855 SEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQAN-----AHLTKFRKAQHELEE 1906
Score = 103 bits (256), Expect = 7e-22
Identities = 131/691 (18%), Positives = 308/691 (44%), Gaps = 73/691 (10%)
Query: 47 QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKI---LEKEIRVLLQERGAQD 103
Q ES+ L+ ++ A+ ++ K+ +++ + + +I L + R L E
Sbjct: 893 QAESENLLDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELK 952
Query: 104 RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKN 163
+ I DLE L K+E +A + +L+ + L++ + +LTR + L + +Q+
Sbjct: 953 KDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKAL-----QEAHQQA 1007
Query: 164 LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKE 223
L L E K+ + +TK + + + E +E L+ ++ + + +LEG L ++
Sbjct: 1008 LDDLQAEEDKVNSLNKTKSK-LEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQES 1066
Query: 224 KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE---NI 280
+D +++ ++L ++++K + QL+ ++++ L ++ ++E I
Sbjct: 1067 ILDLENDKQQL----------DERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARI 1116
Query: 281 VILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL---------NAEMQNLKQ-KFI-LE 329
L +++E EK++ D+ E +E L E+ ++ +F+ L
Sbjct: 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR 1176
Query: 330 QQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ---EEMVKEKNLFEEELKQTLDEL 386
+ E Q E + +L ++ + + L +++ + Q +++ KEK+ F+ E+ +
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236
Query: 387 DKLQQKEEQAERLVKQLEE---EAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQ 443
+ + + + E++ + LE+ EA+ + EE++ +L +++ L+ + + + L+
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAG---ELSRQLE 1293
Query: 444 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
EK +S+V L F ++E+ ++L + + + ++ Q +
Sbjct: 1294 EK-ESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQ 1352
Query: 504 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
E R L ++ A T+ + + +++ + + +L Q+ +D +Q+E +
Sbjct: 1353 EGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKC 1412
Query: 564 AEKENT-------TAELTEEINKWRLLYEELYNKTKPF-------QLQLDAFEVEKQALL 609
A E T +L ++ + L L K + F + + + + E +A L
Sbjct: 1413 ASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASL 1472
Query: 610 NEHGAAQEQLNKIRDSYAKLLG--------HQNLKQKIKHVVKLKDENSQLKSEVSKLRC 661
E + +L K++++Y + L ++NL+Q+I + + EN + E+ K R
Sbjct: 1473 KESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIHELEKSRK 1532
Query: 662 QLAKKK--------QSETKLQEELNKVLGIK 684
Q+ +K ++E L+ E K+L I+
Sbjct: 1533 QIELEKADIQLALEEAEAALEHEEAKILRIQ 1563
Score = 100 bits (250), Expect = 4e-21
Identities = 162/774 (20%), Positives = 324/774 (41%), Gaps = 106/774 (13%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKD 84
D+ LE+ V +K + K + L+ D T+ R+ K+ + + +D
Sbjct: 954 DIDDLELTLAKVEKEKHATENKVKNLTEELS-GLDETIAKLTREKKALQEAHQQALDD-- 1010
Query: 85 LKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAAL-REKTSLSANNATLEKQLIE 143
L+ E ++ L + + +++++DLE+ LE+ E +L L R K L + ++ +++
Sbjct: 1011 LQAEEDKVNSLNKTKSKLEQQVEDLESSLEQ-EKKLRVDLERNKRKLEGDLKLAQESILD 1069
Query: 144 LTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSL 203
L + L + + E +L++K E + + Q+ K++ Q +
Sbjct: 1070 LENDKQQLDERLKKK---------DFEYCQLQSKVEDEQTLGLQFQK----KIKELQARI 1116
Query: 204 EESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS-CASDQVEKYKLDIAQ----- 257
EE + +I EK++ D E E+L E +EE S Q+E K A+
Sbjct: 1117 EELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLR 1176
Query: 258 --LEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEK-------------- 301
LEE + + +L++ +++ L +Q+++L Q LEKEK
Sbjct: 1177 RDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSM 1236
Query: 302 -----------------EDHVNRNREHNENLNAEMQNLK-QKFILEQQERE---KLQQKE 340
ED ++ R NE + + L QK L+ + E +L++KE
Sbjct: 1237 ESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKE 1296
Query: 341 LQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLV 400
I S L + K+ + ++L EE K KN L+ + + D L+++ E+ +
Sbjct: 1297 -SIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK 1355
Query: 401 KQL------------------EEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 442
+L E +A R EEL+ ++KL + + E+ A L
Sbjct: 1356 AELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASL 1415
Query: 443 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 502
++ + +ED+ E +L A+ + + + L E K ++ +++ + +
Sbjct: 1416 EKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKES 1475
Query: 503 ESSNQEYVRMLLDLQTKSALKETE-IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 561
S + E + L + AL + E +K + Q+I DL Q+ + + E E+
Sbjct: 1476 RSLSTELFK--LKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENGKTIH---ELEKS 1530
Query: 562 RK-AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLN 620
RK E E +L E + L +EE K ++QL+ +V K + + E++
Sbjct: 1531 RKQIELEKADIQLALEEAEAALEHEE----AKILRIQLELTQV-KSEIDRKIAEKDEEIE 1585
Query: 621 KIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLK----SEVSKLRCQLAKKKQSETKLQEE 676
+++ +Y + + + ++ + V+ ++E +LK +++++ QL+ + + +
Sbjct: 1586 QLKRNYQRTV--ETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKH 1643
Query: 677 LNKVLG-IK----HFDPSKAFHHESKENFAL---KTPLKEGNTNCYRAPMECQE 722
L V G +K H D + + KE A+ + L + RA +E E
Sbjct: 1644 LRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE 1697
Score = 76.3 bits (186), Expect = 1e-13
Identities = 106/505 (20%), Positives = 219/505 (43%), Gaps = 65/505 (12%)
Query: 46 QQKESKQNLNVDKDTTLPASARKVKSS--ESKKESQKNDKDLKILEKEIRVLLQERGAQD 103
++ +++ ++ + +L K+K++ E+ + + ++ K LE+EI L ++
Sbjct: 1462 EESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQIAENG 1521
Query: 104 RRIQDLETELEKME---ARLNAALRE-KTSLSANNATLEKQLIELTRTNELLKSKFSENG 159
+ I +LE +++E A + AL E + +L A + + +ELT+ + K +E
Sbjct: 1522 KTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKD 1581
Query: 160 NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVS 219
+ +E +K RN + T E M+ L RS E+ ++EG L
Sbjct: 1582 EE-------IEQLK-RNYQRTV--------ETMQSALDAEVRSRNEAIRLKKKMEGDLNE 1625
Query: 220 IEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEEN 279
IE + + + L+++ + + + D + +E+LKE+ L++ +E
Sbjct: 1626 IEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQ----LAI---VERR 1678
Query: 280 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 339
+L +VE+L + E+ ++ L ++ +L+ ER +Q
Sbjct: 1679 ANLLQAEVEELRATLEQTERARK-------------------LAEQELLDSNER--VQLL 1717
Query: 340 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL-------DELDKLQQK 392
Q SL+ +K+L + L Q L S E+ ++ EE+ K+ + +EL K Q
Sbjct: 1718 HTQNTSLIHTKKKLETDLMQ-LQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDT 1776
Query: 393 EEQAERLVKQLEEEAKSRAEELKLLEE-KLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 451
ER+ K LE+ K L E+ LKG + +++K + L+ + +
Sbjct: 1777 SAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTE 1836
Query: 452 SLEDVTAQFESYKALTASEIED----LKLEN--SSLQEKAAKAGKNAEDVQHQILATESS 505
S++ + K LT ED L+L++ LQ K + AE+ Q A +
Sbjct: 1837 SVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTK 1896
Query: 506 NQEYVRMLLDLQTKSALKETEIKEI 530
++ L + + ++ + E+++ ++
Sbjct: 1897 FRKAQHELEEAEERADIAESQVNKL 1921
Score = 62.0 bits (149), Expect = 2e-09
Identities = 85/444 (19%), Positives = 191/444 (43%), Gaps = 76/444 (17%)
Query: 51 KQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGA----QDRRI 106
++N N++++ + + ++ ++ E +K+ K +++ + +I++ L+E A ++ +I
Sbjct: 1501 RENKNLEQEIA-DLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKI 1559
Query: 107 QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRI 166
++ EL ++++ ++ + EK + +E+ RT E ++S +N
Sbjct: 1560 LRIQLELTQVKSEIDRKIAEK------DEEIEQLKRNYQRTVETMQSALDAEVRSRN--- 1610
Query: 167 LSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ-------------- 212
E ++L+ K E + + + + T + L QG++
Sbjct: 1611 ---EAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQED 1667
Query: 213 LEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL 272
L+ +L +E+ ++E E+L +E+ A E+ LD + + L +N ++
Sbjct: 1668 LKEQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHT 1727
Query: 273 KQSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAEMQNL 322
K+ LE +++ L +VED + + E++ + + + + ++ + +L +NL
Sbjct: 1728 KKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL 1787
Query: 323 KQ-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSFQEEM 368
+Q + L++ E+ L+ + QI L + +EL L K E
Sbjct: 1788 EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERR 1847
Query: 369 VKEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEE-----------------EA 407
VKE EE ++ + D +DKLQ K + +R ++ +E EA
Sbjct: 1848 VKELTYQSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEA 1907
Query: 408 KSRAEELKLLEEKLKGKEAELEKS 431
+ RA+ + KL+ K + S
Sbjct: 1908 EERADIAESQVNKLRAKTRDFTSS 1931
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 117 bits (293), Expect = 4e-26
Identities = 121/546 (22%), Positives = 248/546 (45%), Gaps = 50/546 (9%)
Query: 172 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
MKL K + ++ ++E MK + T+ L +++ K +LE K+V++ +EK D +
Sbjct: 834 MKLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQL 893
Query: 230 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 282
+ + + + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 894 QVQAEADSLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 953
Query: 283 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 342
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+ Q
Sbjct: 954 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1009
Query: 343 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 402
LQ E++ ++L + ++++ + E+E K +D L++ + + E +K
Sbjct: 1010 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKIRMD----LERAKRKLEGDLKL 1065
Query: 403 LEEEAKSRAEELKLLEEKLKGKEAELE--KSSAAHTQAT-LLLQEKYDSMVQSLEDVTAQ 459
+E + + L+EKLK KE E+ +S QA + LQ+K + +E++ +
Sbjct: 1066 AQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEE 1125
Query: 460 FESYKALTA---SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDL 516
E+ +A A + DL E + E+ +AG QI + E+ +M DL
Sbjct: 1126 IEAERASRAKAEKQRSDLSRELEEISERLEEAG---GATSAQIEMNKKREAEFQKMRRDL 1182
Query: 517 QTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEE 576
+ + E + + +L Q+ + +++LE E+ + + A E
Sbjct: 1183 EEATLQHEATAATLRKKHADSVAELGEQIDNLQR-VKQKLEKEKSEMKMEIDDLASNMET 1241
Query: 577 INKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL------ 630
++K + E++ + ++ E E+Q L+N+ A + +L Y++ L
Sbjct: 1242 VSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTL 1301
Query: 631 ------GHQNLKQKIKHVVKLKDENSQLKSEVSK-----------LRCQLAKKKQSETKL 673
G Q Q+I+ + + +E + KS ++ LR Q ++++++ +L
Sbjct: 1302 VSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAEL 1361
Query: 674 QEELNK 679
Q ++K
Sbjct: 1362 QRAMSK 1367
Score = 111 bits (277), Expect = 3e-24
Identities = 138/693 (19%), Positives = 306/693 (44%), Gaps = 85/693 (12%)
Query: 45 KQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDR 104
+Q+K+ + +L K L + + S E+ K D K+ +KE + + +D
Sbjct: 1043 EQEKKIRMDLERAK-RKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDE 1101
Query: 105 RI--QDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 162
+ L+ ++++++AR+ E + A+ A EKQ +L+R E + + E G
Sbjct: 1102 QALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1161
Query: 163 NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG-KIAQLEGKLVSIE 221
+ +I ++ KRE + + M E ++ + T +L + +A+L ++ +++
Sbjct: 1162 SAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1215
Query: 222 KEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIV 281
+ K + E ++ I++++ + V K K LE+ + D++ +K EE
Sbjct: 1216 RVKQKLEKEKSEMKMEIDDLASNMETVSKAK---GNLEKMCRALEDQLSEIKTKEEEQ-- 1270
Query: 282 ILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKEL 341
+ + DL + L+ E ++ +R + + L +++ KQ F + +E ++ ++E+
Sbjct: 1271 --QRLINDLTAQRARLQTESGEY-SRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEI 1327
Query: 342 QIDSLL------------------QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTL 383
+ S L ++E+E + L + + E+ + + +E + Q
Sbjct: 1328 KAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT 1387
Query: 384 DELD----KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQAT 439
+EL+ KL Q+ + AE V+ + + S + + L+ +++ ++E+++AA
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACA--- 1444
Query: 440 LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
D ++ + + A+++ T +E+E + E+ SL + K E+ Q+
Sbjct: 1445 -----ALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQL 1499
Query: 500 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
+ N+ + + DL + A I E+ +++ +++L+ E+ LE E
Sbjct: 1500 ETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVEQEKSELQAALEEAEASLEHE 1558
Query: 560 EGR-----------KAEKENTTAELTEEINKWR------------LLYEELYNKTKPFQL 596
EG+ K+E + AE EEI++ + L E+ ++ +L
Sbjct: 1559 EGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL 1618
Query: 597 QL----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQ 651
+ D E+E Q L + + A E L R++ A L Q +L ++ LK++ +
Sbjct: 1619 KKKMEGDLNEMEIQ-LNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAM 1677
Query: 652 -------LKSEVSKLRCQLAKKKQSETKLQEEL 677
L++E+ +LR L + ++S ++EL
Sbjct: 1678 VERRANLLQAEIEELRATLEQTERSRKIAEQEL 1710
Score = 106 bits (264), Expect = 9e-23
Identities = 145/720 (20%), Positives = 313/720 (43%), Gaps = 113/720 (15%)
Query: 68 KVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREK 127
K + ++K+E K + K LE+++ L+QE+ ++Q L E R + ++ K
Sbjct: 857 KEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKTK 916
Query: 128 TSLSA------NNATLEKQL-IELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKR-- 178
L A A E+++ ELT L+ + SE +K++ L L L K+ ++
Sbjct: 917 IQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE--LKKDIDDLELTLAKVEKEKHA 974
Query: 179 -ETKMRGMMAKQEGME---MKLQVTQRSLEESQGK----IAQLEGKLVSIEKEKIDEKSE 230
E K++ + + G++ KL +++L+E+ + + E K+ ++ K KI + +
Sbjct: 975 TENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQ 1034
Query: 231 TEKLLEYIE------------------EISCASDQVEKYKLDIAQLEENLKEKNDEILSL 272
+ L +E ++ A + + D QL+E LK+K E+ L
Sbjct: 1035 VDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGL 1094
Query: 273 KQSLEENIVI---LSKQVEDLNVKCQLLEKEKE-DHVNRNR--EHNENLNAEMQNLKQKF 326
+ +E+ + L K++++L + + LE+E E + +R + + +L+ E++ + ++
Sbjct: 1095 QSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL 1154
Query: 327 ------ILEQQEREKLQQKELQ-----IDSLLQQEKELSSSLHQK--------------L 361
Q E K ++ E Q ++ Q + +++L +K L
Sbjct: 1155 EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNL 1214
Query: 362 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE---EAKSRAEELKLLE 418
++++ KEK+ + E+ ++ + + + E++ + LE+ E K++ EE + L
Sbjct: 1215 QRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI 1274
Query: 419 EKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSL----EDVTAQFESYKALTASEIEDL 474
L + A L+ S +++ L EK D++V L + T Q E K EI+
Sbjct: 1275 NDLTAQRARLQTESGEYSRQ---LDEK-DTLVSQLSRGKQAFTQQIEELKRQLEEEIK-- 1328
Query: 475 KLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSF 534
S+L + + + ++ Q + + E R + ++ A T+ + +
Sbjct: 1329 --AKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQR 1386
Query: 535 LQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE-------L 587
+++ + + +L Q+ +D + +E + A E T L E+ + E L
Sbjct: 1387 TEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAAL 1446
Query: 588 YNKTKPF-------QLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG--------H 632
K + F + + + E +A E + +L KI+++Y + L +
Sbjct: 1447 DKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLETLKREN 1506
Query: 633 QNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK--------QSETKLQEELNKVLGIK 684
+NL+Q+I + + E + E+ K++ Q+ ++K ++E L+ E K+L I+
Sbjct: 1507 KNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQ 1566
Score = 104 bits (259), Expect = 3e-22
Identities = 146/688 (21%), Positives = 315/688 (45%), Gaps = 76/688 (11%)
Query: 42 QRFKQQKE---SKQNLNVDKDTTLPASARKVKSSESKKESQKNDK--DLKILEKEIRVLL 96
QR KQ+ E S+ + +D + + K K + K D+ ++K E+E + L+
Sbjct: 1215 QRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLI 1274
Query: 97 QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
+ AQ R+Q + +L++ + ++ R K + + L++QL E +
Sbjct: 1275 NDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALA 1334
Query: 149 ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 193
+LL+ ++ E Q+ + + E+ + R K ET + +E E
Sbjct: 1335 HALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETD--AIQRTEELEE 1392
Query: 194 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
K ++ QR L++++ + + K S+EK K ++E E L+ +E + A ++K +
Sbjct: 1393 AKKKLAQR-LQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQR 1451
Query: 254 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
+ ++ K+K +E + ++ ++ LS ++ K + +E D + + N+
Sbjct: 1452 NFDKILAEWKQKCEETHAELEASQKESRSLSTEL----FKIKNAYEESLDQLETLKRENK 1507
Query: 314 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 373
NL E+ +L ++ + +L++ + Q++ Q++ EL ++L + S + E K
Sbjct: 1508 NLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKSELQAALEEAEASLEHEEGKILR 1564
Query: 374 LFEEELKQTLDELD-KLQQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEEKL 421
+ + EL Q E+D K+ +K+E+ +++ + L+ E +SR + ++L ++K+
Sbjct: 1565 I-QLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRL-KKKM 1622
Query: 422 KG--KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENS 479
+G E E++ + A A L Y + L+D + AL + E DLK + +
Sbjct: 1623 EGDLNEMEIQLNHANRMAAEAL--RNYRNTQAILKDTQLHLDD--ALRSQE--DLKEQLA 1676
Query: 480 SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 539
++ +A E+++ + TE S + + LLD + L T+ + + + T
Sbjct: 1677 MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET 1736
Query: 540 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTK 592
D+ +Q++ + ED ++ + E + + A + EE+ K + + L K
Sbjct: 1737 DI-SQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVK 1795
Query: 593 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 652
Q +LD E E+ AL ++Q+ K+ +L G +QK ++V +K
Sbjct: 1796 DLQHRLD--EAEQLAL----KGGKKQIQKLEARVRELEGEVESEQK-RNVEAVKGLRKH- 1847
Query: 653 KSEVSKLRCQLAKKKQSETKLQEELNKV 680
+ +V +L Q + +++ +LQ+ ++K+
Sbjct: 1848 ERKVKELTYQTEEDRKNILRLQDLVDKL 1875
Score = 77.4 bits (189), Expect = 4e-14
Identities = 95/435 (21%), Positives = 193/435 (44%), Gaps = 54/435 (12%)
Query: 22 GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKKESQ 79
G + LE +K V +KS+ +E++ +L ++ L +VKS +K ++
Sbjct: 1523 GGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1582
Query: 80 KNDKDLKILEKEIRVLLQERGAQDRRIQD----------LETELEKMEARLN-------A 122
K+++ ++ IR++ + D I+ +E +L +ME +LN
Sbjct: 1583 KDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1642
Query: 123 ALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TK 181
ALR + A + L + R+ E LK + + + NL L E+ +LR E T+
Sbjct: 1643 ALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTE 1700
Query: 182 MRGMMAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
+A+QE ++ +V T++ LE I+Q++G++ I +E ++
Sbjct: 1701 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQIQGEMEDIIQEA---RN 1754
Query: 230 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SK 285
EK + I + + +++++K + A LE K + L+ L+E + K
Sbjct: 1755 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK 1814
Query: 286 QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 345
Q++ L + + LE E E RN E + L + +K+ +++R+ + + + +D
Sbjct: 1815 QIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILRLQDLVDK 1874
Query: 346 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 405
L + K EE ++ N+ + ++ EL++ +++ + AE V +L
Sbjct: 1875 LQAKVKSYKRQ--------AEEAEEQSNVNLSKFRRIQHELEEAEERADIAESQVNKL-- 1924
Query: 406 EAKSRAEELKLLEEK 420
KSR K++ E+
Sbjct: 1925 RVKSREVHTKIISEE 1939
Score = 63.9 bits (154), Expect = 5e-10
Identities = 107/497 (21%), Positives = 210/497 (42%), Gaps = 73/497 (14%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSS--ESKKESQKNDKDLKILEKEIRVLL 96
QK + + E+ Q + +L K+K++ ES + + ++ K L++EI L
Sbjct: 1462 QKCEETHAELEASQK----ESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLT 1517
Query: 97 QERGAQDRRIQDLET---ELEKMEARLNAALRE-KTSLSANNATLEKQLIELTRTNELLK 152
++ +RI +LE ++E+ ++ L AAL E + SL + + +EL + +
Sbjct: 1518 EQIAEGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1577
Query: 153 SKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ 212
K +E + ++ MK + R E M+ L RS ++ +
Sbjct: 1578 RKIAEKDEE-------IDQMKRNHIRIV---------ESMQSTLDAEIRSRNDAIRLKKK 1621
Query: 213 LEGKLVSIE----------KEKIDEKSETEKLLEYIE-EISCASDQVEKYKLDIAQLEEN 261
+EG L +E E + T+ +L+ + + A E K +A +E
Sbjct: 1622 MEGDLNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERR 1681
Query: 262 LKEKNDEILSLKQSLEE---NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN-- 316
EI L+ +LE+ + I +++ D + + QLL + +N ++ +++
Sbjct: 1682 ANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQI 1741
Query: 317 -AEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 375
EM+++ Q+ +++ +K + L++E++ S+ L E M K
Sbjct: 1742 QGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL--------ERMKKNLEQT 1793
Query: 376 EEELKQTLDELDKL---------QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA 426
++L+ LDE ++L Q+ E + L ++E E K E +K L K + K
Sbjct: 1794 VKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGL-RKHERKVK 1852
Query: 427 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS----LQ 482
EL + + L LQ+ D + A+ +SYK A E E+ N S +Q
Sbjct: 1853 ELTYQTEEDRKNILRLQDLVDKL-------QAKVKSYKR-QAEEAEEQSNVNLSKFRRIQ 1904
Query: 483 EKAAKAGKNAEDVQHQI 499
+ +A + A+ + Q+
Sbjct: 1905 HELEEAEERADIAESQV 1921
Score = 33.1 bits (74), Expect = 0.93
Identities = 39/166 (23%), Positives = 71/166 (42%), Gaps = 36/166 (21%)
Query: 535 LQKITDLQNQLKQQEEDFRKQLED---EEGRKAEKENTTAELTEEINKWRLLY------- 584
L K + + ++ +E+F K E+ E ++ E E L +E N +L
Sbjct: 843 LLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSL 902
Query: 585 ---EELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKH 641
EE ++ ++QL+A K + E +E++N A+L +
Sbjct: 903 ADAEERCDQLIKTKIQLEA----KIKEVTERAEDEEEIN------AELTAKKR------- 945
Query: 642 VVKLKDENSQLKSEVSKLRCQLAK----KKQSETKLQEELNKVLGI 683
KL+DE S+LK ++ L LAK K +E K++ ++ G+
Sbjct: 946 --KLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGL 989
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 117 bits (292), Expect = 5e-26
Identities = 133/551 (24%), Positives = 259/551 (47%), Gaps = 60/551 (10%)
Query: 172 MKLRNKRETKMRGMMAKQEGMEMKLQVTQ--RSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
MKL K + ++ ++E MK + T+ +LE+S+ + +LE K+VS+ +EK D +
Sbjct: 830 MKLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL 889
Query: 230 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND----------EILSLKQSLEEN 279
+ + + + + DQ+ K K+ QLE +KE N+ E+ + K+ LE+
Sbjct: 890 QVQAEQDNLADAEERCDQLIKNKI---QLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 280 IVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK 339
L + ++DL + +EKEK N+ + NL EM L + +E++ LQ+
Sbjct: 947 CSELKRDIDDLELTLAKVEKEKHATENKVK----NLTEEMAGLDEIIAKLTKEKKALQEA 1002
Query: 340 ELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERL 399
Q LQ E++ ++L + ++++ + E+E K +D L++ + + E
Sbjct: 1003 HQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMD----LERAKRKLEGD 1058
Query: 400 VKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLL---LQEKYDSMVQSLEDV 456
+K +E + + L+E+LK K+ EL +A L LQ+K + +E++
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118
Query: 457 TAQFESYKALTASEIE----DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRM 512
+ E+ + A ++E DL E + E+ +AG A V QI + E+ +M
Sbjct: 1119 EEELEAERTARA-KVEKLRSDLSRELEEISERLEEAG-GATSV--QIEMNKKREAEFQKM 1174
Query: 513 LLDLQ--------TKSALKETEIKEITVSFLQKITDLQ---NQLKQQEEDFRKQLEDEEG 561
DL+ T +AL++ + ++I +LQ +L++++ +F+ +L+D
Sbjct: 1175 RRDLEEATLQHEATAAALRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEFKLELDDVTS 1233
Query: 562 R-------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL---LNE 611
KA E L +++N+ R EE Q + E L L+E
Sbjct: 1234 NMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE 1293
Query: 612 HGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKK-QSE 670
A QL + + +Y + L ++LK++++ VK K+ + + ++ C L +++ + E
Sbjct: 1294 KEALISQLTRGKLTYTQQL--EDLKRQLEEEVKAKNALAH-ALQSARHDCDLLREQYEEE 1350
Query: 671 TKLQEELNKVL 681
T+ + EL +VL
Sbjct: 1351 TEAKAELQRVL 1361
Score = 107 bits (267), Expect = 4e-23
Identities = 155/723 (21%), Positives = 300/723 (41%), Gaps = 102/723 (14%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQER 99
K Q + KE + L +++ +A+K K + E +++ DL++ ++ +E+
Sbjct: 912 KIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVE---KEK 968
Query: 100 GAQDRRIQDLETELEKMEARLNAALREKTSLS-ANNATLEKQLIELTRTNELLKSKFS-- 156
A + ++++L E+ ++ + +EK +L A+ L+ E + N L K+K
Sbjct: 969 HATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLE 1028
Query: 157 --------------------ENGNQK---NLRILSLELMKLRN----------KRETKMR 183
E +K +L++ +M L N K++ ++
Sbjct: 1029 QQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELN 1088
Query: 184 GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL-------VSIEKEKIDEKSETEKLLE 236
+ A+ E + Q+ L+E Q +I +LE +L +EK + D E E++ E
Sbjct: 1089 ALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE 1148
Query: 237 YIEEISCASD-QVEKYKLDIAQLEENLKEKNDEIL-------SLKQSLEENIVILSKQVE 288
+EE A+ Q+E K A+ ++ ++ + L +L++ +++ L +Q++
Sbjct: 1149 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID 1208
Query: 289 DLNVKCQLLEKEKE------DHVNRNREHNENLNAEMQNLKQKFILEQQ----------- 331
+L Q LEKEK D V N E A ++ + + LE Q
Sbjct: 1209 NLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRT--LEDQMNEHRSKAEET 1266
Query: 332 ---------EREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQT 382
+R KLQ + ++ L +++ L S L + ++ +++ K EEE+K
Sbjct: 1267 QRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAK 1326
Query: 383 LDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLL 442
LQ + L +Q EEE +++AE ++L + K Q T L
Sbjct: 1327 NALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL 1386
Query: 443 QEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 502
+E + Q L++ E+ A +S L+ LQ + + E A
Sbjct: 1387 EEAKKKLAQRLQEAEEAVEAVNAKCSS----LEKTKHRLQNEIEDLMVDVERSNAAAAAL 1442
Query: 503 ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 562
+ + + ++L + + K ++E++ S ++ L +L + + + + LE E
Sbjct: 1443 DKKQRNFDKILAEWKQKYEESQSELE----SSQKEARSLSTELFKLKNAYEESLEHLETF 1498
Query: 563 KAEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE-Q 618
K E +N E LTE++ EL K QL+A ++E Q+ L E A+ E +
Sbjct: 1499 KRENKNLQEEISDLTEQLGSSGKTIHELEKVRK----QLEAEKMELQSALEEAEASLEHE 1554
Query: 619 LNKIRDSYAKLLGHQNLKQKIKHVVKLKDEN-SQLKSEVSKLRCQLAKKKQSETKLQEEL 677
KI + L +K +I+ + KDE Q K ++ L +ET+ + E
Sbjct: 1555 EGKILRAQ---LEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEA 1611
Query: 678 NKV 680
+V
Sbjct: 1612 LRV 1614
Score = 95.1 bits (235), Expect = 2e-19
Identities = 136/699 (19%), Positives = 291/699 (41%), Gaps = 71/699 (10%)
Query: 37 SFQKSQRFKQQKESKQN--LNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRV 94
+ +KS+ +++ E K L D L A + +++++ + K+ LE +++
Sbjct: 862 ALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQLEAKVKE 921
Query: 95 LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSK 154
+ + ++ +L + K+E + R+ L A +EK E T +K+
Sbjct: 922 MNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK---EKHATENKVKNL 978
Query: 155 FSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
E G + + L+ E L+ + + + A+++ K+ ++ + + ++ L
Sbjct: 979 TEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED----KVNTLTKAKVKLEQQVDDL 1034
Query: 214 EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
EG L +K ++D + KL ++ + + + D QL+E LK+K+ E+ +L
Sbjct: 1035 EGSLEQEKKVRMDLERAKRKL---EGDLKLTQESIMDLENDKQQLDERLKKKDFELNALN 1091
Query: 274 QSLEENIVI---LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
+E+ + L K++++L + + LE+E E A+++ L+ E
Sbjct: 1092 ARIEDEQALGSQLQKKLKELQARIEELEEE--------LEAERTARAKVEKLRSDLSREL 1143
Query: 331 QE-REKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKL 389
+E E+L++ ++ K+ + + +E ++ + K+ D + +L
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAEL 1203
Query: 390 QQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 449
++ + +R+ ++LE+E E KL + + ++ K+ A + M
Sbjct: 1204 GEQIDNLQRVKQKLEKE----KSEFKLELDDVTSNMEQIIKAKA-----------NLEKM 1248
Query: 450 VQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEY 509
++LED + S T + DL + + LQ + + + ++ + I Y
Sbjct: 1249 CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTY 1308
Query: 510 VRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENT 569
+ L DL+ + +E + K LQ + + R+Q E+E KAE +
Sbjct: 1309 TQQLEDLK-RQLEEEVKAKNALAHALQ-------SARHDCDLLREQYEEETEAKAELQRV 1360
Query: 570 TAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL 629
++ E+ +WR YE T Q + + E K+ L A+E + + + L
Sbjct: 1361 LSKANSEVAQWRTKYE-----TDAIQ-RTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSL 1414
Query: 630 LGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLA---KKKQSETKLQEELNKVLGIKHF 686
+K KH +L++E L +V + A KK+++ K+ E + K+
Sbjct: 1415 -------EKTKH--RLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQ----KYE 1461
Query: 687 DPSKAFHHESKENFALKTPLKEGNTNCYRAPMECQESWK 725
+ KE +L T L + N Y +E E++K
Sbjct: 1462 ESQSELESSQKEARSLSTELFK-LKNAYEESLEHLETFK 1499
Score = 89.4 bits (220), Expect = 1e-17
Identities = 148/749 (19%), Positives = 307/749 (40%), Gaps = 138/749 (18%)
Query: 42 QRFKQQKESKQN---LNVDKDTTLPASARKVKSSESKK----ESQKNDKDLKILE--KEI 92
QR KQ+ E +++ L +D T+ K K++ K E Q N+ K E + +
Sbjct: 1211 QRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSV 1270
Query: 93 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
L +R +L +L++ EA ++ R K + + L++QL E +
Sbjct: 1271 NDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALA 1330
Query: 149 ----------ELLKSKFSENGNQKN--LRILSL---ELMKLRNKRETKMRGMMAKQEGME 193
+LL+ ++ E K R+LS E+ + R K ET + +E E
Sbjct: 1331 HALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETD--AIQRTEELEE 1388
Query: 194 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
K ++ QR L+E++ + + K S+EK K ++E E L+ +E + A+ ++K +
Sbjct: 1389 AKKKLAQR-LQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQR 1447
Query: 254 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
+ ++ K+K +E S +S ++ LS ++ K + +E +H+ + N+
Sbjct: 1448 NFDKILAEWKQKYEESQSELESSQKEARSLSTEL----FKLKNAYEESLEHLETFKRENK 1503
Query: 314 NLNAEMQNLKQ------KFILEQQE-REKLQQKELQIDSLLQQEK--------------- 351
NL E+ +L + K I E ++ R++L+ +++++ S L++ +
Sbjct: 1504 NLQEEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQL 1563
Query: 352 ---ELSSSLHQKLCSFQEEMVKEKN---LFEEELKQTLD------------------ELD 387
++ + + +KL EEM + K + L+ +LD +L+
Sbjct: 1564 EFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLN 1623
Query: 388 KLQQKEEQAERLVKQLEEEAKS-------------------------------------- 409
+++ + A R+ + +++ KS
Sbjct: 1624 EMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQA 1683
Query: 410 RAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS 469
EEL+ + E+ + E+ ++ LL + S++ + + A + +
Sbjct: 1684 ELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQ----T 1739
Query: 470 EIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 529
E+E+ E + +EKA KA +A + ++ + ++ RM +++ + + E
Sbjct: 1740 EVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDE 1799
Query: 530 ITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYN 589
L+ +L+ + + +LE E+ R AE + I + EE
Sbjct: 1800 AEQIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRK 1859
Query: 590 KTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDEN 649
Q +D +++ +A + A+EQ N + +K++H + +E
Sbjct: 1860 NLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKF----------RKVQHELDEAEER 1909
Query: 650 SQL-KSEVSKLRCQLAKKKQSETK-LQEE 676
+ + +S+V+KLR AK + TK L EE
Sbjct: 1910 ADIAESQVNKLR---AKSRDIGTKGLNEE 1935
Score = 73.2 bits (178), Expect = 8e-13
Identities = 97/484 (20%), Positives = 213/484 (44%), Gaps = 74/484 (15%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSS--ESKKESQKNDKDLKILEKEIRVLL 96
QK + + + ES Q + +L K+K++ ES + + ++ K L++EI L
Sbjct: 1458 QKYEESQSELESSQK----EARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLT 1513
Query: 97 QERGAQDRRIQDLETELEKMEAR---LNAALRE-KTSLSANNATLEKQLIELTRTNELLK 152
++ G+ + I +LE +++EA L +AL E + SL + + +E + ++
Sbjct: 1514 EQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIE 1573
Query: 153 SKFSENGNQ----KNLRILSLELMKLRNKRETKMRG----MMAKQEG----MEMKLQVTQ 200
K +E + K + ++ ++ ET+ R + K EG ME++L
Sbjct: 1574 RKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHAN 1633
Query: 201 RSLEESQGKIAQLEGKLVSIEKEKIDE---------------------KSETEKLLEYIE 239
R E+Q ++ L+ L + + D ++E E+L +E
Sbjct: 1634 RMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVE 1693
Query: 240 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 299
+ + E+ ++ ++ + L +N +++ K+ ++ ++ L +VE+ +C+ E+
Sbjct: 1694 QTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEE 1753
Query: 300 EKE----------DHVNRNREHNENLNAEMQNLKQ-----KFILEQQEREKLQQKELQID 344
+ + + + + ++ + +L +N++Q + L++ E+ L+ + Q+
Sbjct: 1754 KAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKGGKKQLQ 1813
Query: 345 SLLQQEKELSSSLHQ---------KLCSFQEEMVKEKNLFEEELKQTL----DELDKLQQ 391
L + +EL + L K E +KE EE ++ L D +DKLQ
Sbjct: 1814 KLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNLLRLQDLVDKLQL 1873
Query: 392 KEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQ 451
K + +R ++ EE+A + + + ++ +L EAE E++ A +Q L + D +
Sbjct: 1874 KVKAYKRQAEEAEEQANTNLSKFRKVQHEL--DEAE-ERADIAESQVNKLRAKSRDIGTK 1930
Query: 452 SLED 455
L +
Sbjct: 1931 GLNE 1934
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 117 bits (292), Expect = 5e-26
Identities = 149/652 (22%), Positives = 290/652 (44%), Gaps = 72/652 (11%)
Query: 70 KSSESKKESQKNDKDLKILEKEI---RVLLQERGAQDRRIQDLETELEKMEARLNAALR- 125
++ E + E +K+ ++L+K+I ++ ++ A ++ +LE E K++ L++
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
Query: 126 --EKTSLSANNATLEKQLIELTRTNELLKS----------KFSENGNQKNLRILSLELMK 173
+ SL N+ L+++ +EL R E LK + E ++K LEL+K
Sbjct: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK 745
Query: 174 LRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEK 233
K+ ++ +G++++ Q Q++LE S KI QLE +L +E E +K
Sbjct: 746 ASFKKTERLE---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM----ENQTLQK 798
Query: 234 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVK 293
LE ++ S +Q+EK + Q L++ ++ + L + I +E+ NVK
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Query: 294 CQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI----LEQQEREKLQQKELQIDSLLQQ 349
LEKE N+ L+ E+ K+ + LE++ +E +++ + I +L+
Sbjct: 859 IGNLEKE-----------NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 350 EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKS 409
++L S +KL + ++M + EL++ ++L E+ + K LE + +S
Sbjct: 908 REDLVS---EKLKT--QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
Query: 410 RAEE-LKLLEEKLKGKEAELEKSSAAHTQATLLL---QEKYDSMVQSLEDVTAQFESYKA 465
++ L++ EEK+ EA LE+S+ + Q L ++ Y+++ Q +D +S
Sbjct: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR-QDEERMVQSSPP 1021
Query: 466 LTASEIEDLKLENSSLQ--EKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 523
++ ED K E S + + K +V+ ++ Q L L+T++
Sbjct: 1022 ISG---EDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL 1078
Query: 524 ETEIKEI---TVSFLQKITDLQNQ----------LKQQEEDFRKQLEDEEGRKAEKENTT 570
+ +I + TVS ++ T LQ Q L Q Q +++ EN
Sbjct: 1079 QAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN 1138
Query: 571 AELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLL 630
+ +E + LY+ L + +L + E ++L+++HG + + + L
Sbjct: 1139 ESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLE 1198
Query: 631 GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 682
N Q +K +L+D LK E K+ L + K ET + E K+ G
Sbjct: 1199 DRYN--QLLKQKGQLEDLEKMLKVEQEKM---LLENKNHET-VAAEYKKLCG 1244
Score = 112 bits (280), Expect = 1e-24
Identities = 160/678 (23%), Positives = 299/678 (44%), Gaps = 90/678 (13%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKS---------SESKKESQKNDKDLKILEK 90
K +R +Q+ E K +D L ++K S+++ D+ + EK
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
Query: 91 EIRV--LLQERGAQDRRIQDLE---TELEKMEARLNAALREKTSLS---ANNATLEKQLI 142
+RV L E R+ D+E +E+++ L KT L +L
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 143 ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV---- 198
EL + N LK+K + ++++ + K+ E M MA+++ M+ L +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDM-----DRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433
Query: 199 -----TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
T E Q + +L S K++ E + L + +EE+ D VE
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLE--MENQSLTKTVEELRTTVDSVEGNAS 491
Query: 254 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
I ++E K ++ LS K + EN ++ KQ CQ L K D + + +
Sbjct: 492 KILKME-----KENQRLSKKVEILENEIVQEKQSLQ---NCQNLSK---DLMKEKAQLEK 540
Query: 314 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 373
+ +N +++ + +QE E L Q S L+Q ++S+ K ++ KE
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTV----SSLRQRSQISAEARVK------DIEKENK 590
Query: 374 LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSA 433
+ E +K+T +L K++ ++ Q ++ ++ +E+ + RAEEL+ L+ KE EL +
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHHLE-KENELLQKKI 648
Query: 434 AHTQATL----LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAG 489
+ + T L+++ + + + +S+K LT ++E L+ ENS L E+ +
Sbjct: 649 TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEENLELR 707
Query: 490 KNAEDV--------QHQILATE-SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
+N E + Q Q+ E S +E ++ L+L K++ K+TE E++ L D
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL-LKASFKKTERLEVSYQGL----D 762
Query: 541 LQNQ-LKQQEEDFRKQLE--DEEGRKAEKENTTAELT-EEINKWRLLYEELYNKTKPFQL 596
++NQ L++ E+ K+++ + E + E EN T + EE+ E+L + K +
Sbjct: 763 IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 597 QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEV 656
+ E +K+ L E+ ++Q +I+D+ L N+K + L+ EN L E+
Sbjct: 823 ETSQLEKDKKQLEKENKRLRQQA-EIKDT---TLEENNVK-----IGNLEKENKTLSKEI 873
Query: 657 S--KLRCQLAKKKQSETK 672
K C K+ + E K
Sbjct: 874 GIYKESCVRLKELEKENK 891
Score = 77.0 bits (188), Expect = 6e-14
Identities = 137/628 (21%), Positives = 264/628 (42%), Gaps = 124/628 (19%)
Query: 139 KQLIELTRTNELL--KSKFSENGNQKNLRILSLEL---MKLRNKRE--TKMRGM-MAKQE 190
+QLI ++ N L+ K+ FSE G ++ ++L L L ++ + K E +++G+ +
Sbjct: 95 QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKA 154
Query: 191 GMEMKLQVTQRSLEE------------SQGKIAQLEGKLVSIEKEKIDEKSE-TEKLLEY 237
+ +Q + E SQ I L + K IDE+ E +E ++E
Sbjct: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214
Query: 238 IEEIS---------------CASDQVEKY-------------KLDIAQLEENLKEKNDEI 269
EE C S +++ K I +L + L+EK +++
Sbjct: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQL 274
Query: 270 LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 329
L KQ LE + E + R ++ N NL ++ ++ + +
Sbjct: 275 LDCKQELE----------------------QMEIELKRLQQENMNLLSDARSAR----MY 308
Query: 330 QQEREKLQQKELQIDSLLQQEKELSSSLH---------QKLCSFQEEMVKEKNLFEEELK 380
+ E + L++K +++D L + LH ++L + +++ K + E++L+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368
Query: 381 QTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 440
T DKL + E++ +L +L + R + K +EE L + LE + +L
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE-LMEENMTLEMAQKQSMDESL 427
Query: 441 LLQEKYDSMVQSLEDVTAQFES----YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 496
L + + + ++ E A +S LT+S + L++EN SL + + + V+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 497 ---HQILATESSNQ-----------EYVRMLLDLQ-----TKSALKETEIKEITVSFLQK 537
+IL E NQ E V+ LQ +K +KE E T+ L++
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 538 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQ 597
++ Q ++ +QE + Q R+ + + A + + + ++L+E + K +
Sbjct: 548 NSERQIKILEQENEHLNQTVSSL-RQRSQISAEARVKDIEKENKILHESI----KETSSK 602
Query: 598 LDAFEVEKQAL------LNEHGAAQEQL-NKIR--DSYAKLLGHQ--NLKQKIKHVVKLK 646
L E EK+ + E G E+L N++ + +LL + NLK + + L+
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 647 DENSQLKSEVSKLRCQLAKKKQSETKLQ 674
ENS+L+ E KL+ L K +L+
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLE 690
Score = 76.6 bits (187), Expect = 7e-14
Identities = 137/595 (23%), Positives = 261/595 (43%), Gaps = 95/595 (15%)
Query: 27 KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESK----------- 75
K+LE + K Q K+ K +Q + KDTTL + K+ + E +
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEI-KDTTLEENNVKIGNLEKENKTLSKEIGIY 876
Query: 76 -------KESQKNDKDL----KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAAL 124
KE +K +K+L I K + L ++ ++ + Q + +LEK+ L
Sbjct: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL---- 932
Query: 125 REKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK-RETKMR 183
EK L+ ++Q + +LL+SK E+ +K+L I ++ L + E+
Sbjct: 933 -EKIGLNKERLLHDEQSTD--DRYKLLESKL-ESTLKKSLEIKEEKIAALEARLEESTNY 988
Query: 184 GMMAKQEGMEMKLQVTQRSLEESQGKIAQ----LEGKLVSIEKEKIDEKSETEKLLEYIE 239
+QE +K + + ++ Q + G+ E+E + E K+ + +
Sbjct: 989 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048
Query: 240 EI--SCASDQVEK--YKLDIAQLEENLKEKNDEILSLKQ---SLEENIVILSKQVEDLNV 292
E+ + A+ Q EK K + QLE +IL+L++ SL+E L Q L V
Sbjct: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
Query: 293 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKE 352
+ L + +N+N + + ++N + I E+++ + L DSL++ ++
Sbjct: 1109 ENSTLNSQSTSLMNQNAQLLIQ-QSSLENENESVIKEREDLKSL------YDSLIKDHEK 1161
Query: 353 LSSSLHQKLCSFQEEMVKE--------KNLFEEELKQTLDELDKLQQKEEQAERLVKQLE 404
L LH++ S E ++ + KNL E E + D ++L +++ Q E L K L+
Sbjct: 1162 L-ELLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
Query: 405 EEAKSRAEELKLLEEK-LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY 463
E +E LLE K + AE +K + + L Y +++ E + ++
Sbjct: 1220 VE-----QEKMLLENKNHETVAAEYKKLCGENDR----LNHTYSQLLKETEVLQTDHKNL 1270
Query: 464 KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ------------EYVR 511
K+L + + KLE + L+ + +K + + Q I +T+ +NQ E R
Sbjct: 1271 KSL----LNNSKLEQTRLEAEFSKLKEQYQ--QLDITSTKLNNQCELLSQLKGNLEEENR 1324
Query: 512 MLLD------LQTKSALKET-EIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
LLD LQ ++ L++ E K++ ++ D N+L++Q+E +++ D+
Sbjct: 1325 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
Score = 72.4 bits (176), Expect = 1e-12
Identities = 130/583 (22%), Positives = 246/583 (42%), Gaps = 79/583 (13%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKK---ESQKNDKDL-KILEKEIRV 94
Q Q K K++ + L +D + S E K ESQ+ ++L K+ ++ I V
Sbjct: 991 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1050
Query: 95 ------LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
L E+ A +++ LET+ ++A++ A R+ SL N TL+ Q +L N
Sbjct: 1051 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1110
Query: 149 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
L S+ + NQ N ++L ++ L N+ E+ ++ L+ SL +
Sbjct: 1111 STLNSQSTSLMNQ-NAQLL-IQQSSLENENESVIK--------EREDLKSLYDSLIKDHE 1160
Query: 209 KIAQLEGKLVSIEKEKIDE----KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 264
K+ L + S + I + KS + L ++ +Q+ K K + LE+ LK
Sbjct: 1161 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1220
Query: 265 KNDEILSLKQSLEENIVILSKQV----EDLNVKCQLLEKEKE----DH------VNRNRE 310
+ +++L L+ E + K++ + LN L KE E DH +N ++
Sbjct: 1221 EQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1279
Query: 311 HNENLNAEMQNLKQKFILEQQEREKL-QQKEL--QIDSLLQQEKELSSSLHQKLC----S 363
L AE LK+++ KL Q EL Q+ L++E Q L +
Sbjct: 1280 EQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRT 1339
Query: 364 FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG 423
E+ ++ K+LF E +Q +D+L++L++++E+ LEEK+
Sbjct: 1340 LLEQNMESKDLFHVEQRQYIDKLNELRRQKEK---------------------LEEKIMD 1378
Query: 424 KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIED----LKLENS 479
+ + S + L K +++S +D+ + + LT + + L+L +
Sbjct: 1379 QYKFYDPSPPRRRGNWITL--KMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1436
Query: 480 SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT----KSALKETEIKEITVSFL 535
Q+ ++ + ED Q L T+ S+ ++ L L+ K +K + ++++ L
Sbjct: 1437 DSQDSSSVGSNSLED--GQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDL 1494
Query: 536 QKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEIN 578
+ L Q E+ + G++ ++ A T IN
Sbjct: 1495 VQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAIN 1537
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 116 bits (291), Expect = 6e-26
Identities = 167/746 (22%), Positives = 325/746 (43%), Gaps = 117/746 (15%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
QK++ F Q E+++N + + +T + ++ +K N + +I E+ RV +
Sbjct: 1857 QKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKM----NLLNQQIQEELSRVTKLK 1912
Query: 99 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
A++ + DLE L A LN ++ +A ++ +L+E N LK SE
Sbjct: 1913 ETAEEEK-DDLEERLMNQLAELNGSIGNYCQ-DVTDAQIKNELLESEMKN--LKKCVSEL 1968
Query: 159 GNQKNLRILSLELMKLRNKRETKMRGMMA-------KQEGMEMKLQVTQRSLEESQGKIA 211
+K +L+K + K E+++R K+ G + + Q L+E Q ++
Sbjct: 1969 EEEKQ------QLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVK 2022
Query: 212 QLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILS 271
QL+ + + EKI T K LE+++ S +E K ++AQ E+ K+ E+ S
Sbjct: 2023 QLQKDCIRYQ-EKISALERTVKALEFVQTES--QKDLEITKENLAQAVEHRKKAQAELAS 2079
Query: 272 LKQSLEENIVILSKQVEDLNVKCQL-LEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
K L++ ++ + D N+K + L+ KE ++ ++ +E+L ++ ++K + E+
Sbjct: 2080 FKVLLDDTQSEAARVLAD-NLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEK 2138
Query: 331 QE---------REKLQQKE----LQI-----DSLLQQEKELSSSLHQKLCSFQEEMVKEK 372
+ REK+ +E +Q+ D +QQ +E S +L +F + M
Sbjct: 2139 KNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSM---- 2194
Query: 373 NLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK-- 430
+ +++ + +DE K ++K A ++ EEE + + + +L+++L+ +E+
Sbjct: 2195 SSLQDDRDRVIDEAKKWERKFSDA---IQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251
Query: 431 -------------SSAAHTQATL------LLQEKYDSMVQSLEDVTAQFESYK---ALTA 468
S A T+ L LQ + ++ LE+ + S + A
Sbjct: 2252 INISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLE 2311
Query: 469 SEIEDLKLENSSLQ---EKAAKAGKNAEDVQHQILAT-ESSNQEYVRMLLDLQTKSAL-- 522
SE++ LK + + L EK + N E + Q A ++S Y ++ DLQ L
Sbjct: 2312 SELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTS 2371
Query: 523 ---KETEIKEITVSFL--------------------QKITDLQNQLKQQEEDFRKQLEDE 559
+E +KE + L ++I +L+N L Q+EE+ LE+E
Sbjct: 2372 RLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEE-NIVLEEE 2430
Query: 560 EGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQL 619
+ +K N E + I K E + K QLD+F +L N+
Sbjct: 2431 NKKAVDKTNQLMETLKTIKK-----ENIQQKA-----QLDSFVKSMSSLQNDRDRIVGDY 2480
Query: 620 NKIRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 677
++ + + ++ Q +++ KLK+E L+S + L + AK + +E+L
Sbjct: 2481 QQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDL 2540
Query: 678 NKVLGIKHFDPSKAFHHESKENFALK 703
N+V+ IK + + ++N L+
Sbjct: 2541 NQVITIKDSQQKQLLEVQLQQNKELE 2566
Score = 112 bits (281), Expect = 9e-25
Identities = 179/785 (22%), Positives = 328/785 (41%), Gaps = 134/785 (17%)
Query: 48 KESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQ 107
K + + L DK+ L +KSS+ + ++ +K K L+KE +LLQ +
Sbjct: 1573 KLALEGLTEDKEK-LVKEIESLKSSKIAESTEWQEKH-KELQKEYEILLQS-------YE 1623
Query: 108 DLETELEKMEARLNAALREKTSL-------SANNATLEKQLIELTRTNELLKSKFSENGN 160
++ E E+++ + A +EK L AN EKQL E + E +K K +
Sbjct: 1624 NVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAK 1683
Query: 161 QKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVT---QRSLEESQGKIAQLEGKL 217
K +IL LE R + E G AK E ME L + LE + + L K
Sbjct: 1684 SKQQKILELEEENDRLRAEVHPAGDTAK-ECMETLLSSNASMKEELERVKMEYETLSKKF 1742
Query: 218 VSIEKEKIDEKSETEKLLEYIE---EISCASDQVEKYKLDIAQLEENLK------EKNDE 268
S+ EK E + L IE + EK+ EE + E+ D
Sbjct: 1743 QSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDS 1802
Query: 269 I-LSLKQSLEENIVILS--------------------KQVEDLNVKCQLLEKEKEDHVNR 307
+ +S + + E++ +Q++ L + LE+EK+ +
Sbjct: 1803 LSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQ----K 1858
Query: 308 NREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQ-EKELSSSLHQKLCSFQE 366
N+E ++ L E L + + E + LQ++ +++ L QQ ++ELS ++ +E
Sbjct: 1859 NKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELS-----RVTKLKE 1913
Query: 367 EMVKEKNLFEEELKQTLDEL------------------DKLQQKEEQAERLVKQLEEEAK 408
+EK+ EE L L EL + L+ + + ++ V +LEEE +
Sbjct: 1914 TAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQ 1973
Query: 409 SRAEELKLLE--------EKLKGKEAEL-EKSSAAHTQATLLLQEKYDSMVQSLEDVTAQ 459
+E +E EK++G + E KS A Q LL+EK + Q +D
Sbjct: 1974 QLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE--LLKEKQQEVKQLQKDCIRY 2031
Query: 460 FESYKAL--TASEIEDLKLENSS----LQEKAAKAGKNAEDVQHQI----LATESSNQEY 509
E AL T +E ++ E+ +E A+A ++ + Q ++ + + + E
Sbjct: 2032 QEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEA 2091
Query: 510 VRMLLD-LQTKSALKETEIKEITVSFLQKITDLQNQLKQQEE-------DFRKQLEDEEG 561
R+L D L+ K L+ + + + QK DL+ +L+Q EE + +++L+
Sbjct: 2092 ARVLADNLKLKKELQSNK-ESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRR 2150
Query: 562 RKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK 621
K E T E+ +NK ++L QL AF +L ++ ++ K
Sbjct: 2151 EKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKK 2210
Query: 622 IRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAK----------KKQS 669
++ + + ++ K + LKD+ Q+ + +L+ +++ K Q+
Sbjct: 2211 WERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQT 2270
Query: 670 ETKLQEEL-------NKVLGIKHFDPSKAFHHESKENFA-----LKTPLKEGNTNCYRAP 717
E +LQ+++ NK L + + ++ +H S+ A LK+ LK+ T+ +
Sbjct: 2271 EVQLQQKVCDTLQGENKEL-LSQLEETRHLYHSSQNELAKLESELKS-LKDQLTDLSNSL 2328
Query: 718 MECQE 722
+C+E
Sbjct: 2329 EKCKE 2333
Score = 112 bits (280), Expect = 1e-24
Identities = 153/653 (23%), Positives = 287/653 (43%), Gaps = 68/653 (10%)
Query: 67 RKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALRE 126
+++ S+++ E Q K L+ E + LL + + EL K+E+ L + +
Sbjct: 2261 KQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQ 2320
Query: 127 KTSLSANNATLEKQ---LIELTRTNE--LLKSKFSENGNQKNL---RILSLELMKLRNKR 178
T LS + ++Q L + R E + SKFS + +L R L+ L + N +
Sbjct: 2321 LTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMK 2380
Query: 179 ETKMRGMMA-KQEGMEMKL----QVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEK 233
E K+ +++ K+E +++ + Q + ++E + ++Q E + + +E+E +T +
Sbjct: 2381 EQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQ 2440
Query: 234 LLEYIEEISCASDQVEKYKLD-IAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNV 292
L+E ++ I + Q +K +LD + +L+ D I+ Q LEE + + + + L
Sbjct: 2441 LMETLKTIKKENIQ-QKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQ 2499
Query: 293 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKL------QQKELQIDSL 346
+ + ++ + R H ++LN+E L + I +++ ++ QQK+L ++
Sbjct: 2500 EAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQL-LEVQ 2558
Query: 347 LQQEKELS---SSLHQKLCSFQ---EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLV 400
LQQ KEL + L +KL + E++ + N +EE + E++ L+ Q R V
Sbjct: 2559 LQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQV 2618
Query: 401 KQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF 460
L+EE L L +LK KE E+ + SA + + + LE+
Sbjct: 2619 TALQEEG-----TLGLYHAQLKVKEEEVHRLSALFSSS--------QKRIAELEEELVCV 2665
Query: 461 ESYKALTASEIED-LKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTK 519
+ A EIED LK E L A E + ++ E R L++++ K
Sbjct: 2666 QKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERV-------AELARDLVEMEQK 2718
Query: 520 SALKETEIKEITV---SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKE-NTTAELTE 575
+ E K +T SF + ++ LQN E+ DE RK + A+L E
Sbjct: 2719 LLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL-----DELKRKYDASLKELAQLKE 2773
Query: 576 E--INKWR--LLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLG 631
+ +N+ R LL E ++ + L E Q LL++ +++ DSY
Sbjct: 2774 QGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSY----- 2828
Query: 632 HQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 684
++ K + L++E L +E+ K R K++S + +V +K
Sbjct: 2829 -NQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLK 2880
Score = 100 bits (249), Expect = 5e-21
Identities = 149/673 (22%), Positives = 293/673 (43%), Gaps = 95/673 (14%)
Query: 36 VSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKN-DKDLK-----ILE 89
+S ++ Q Q KE + T L A ++++ + ++ E Q+ D + + +L
Sbjct: 742 LSEERDQLLSQVKE------LSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLT 795
Query: 90 KEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNE 149
++I L E ++D +I+ L+ EL+ ++ + + SL + E +++E
Sbjct: 796 EQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVR 855
Query: 150 LLKSKFSENG---NQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEES 206
+ SK E +QK L I ++ + L KR+ + +Q E QVT+ S +
Sbjct: 856 HISSKVEELSQALSQKELEITKMDQLLLEKKRDVET----LQQTIEEKDQQVTEISFSMT 911
Query: 207 QGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKN 266
+ K+V + +EK E + L E + +S A + ++ + ++ LK+
Sbjct: 912 E--------KMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNY 963
Query: 267 DEILSL----KQSLEENIVILSKQVEDLNVKCQ---LLEKEKEDHVNRNREHNENLNAEM 319
DE+ K+ L+ +L K+ E K Q + KE V+R E NL E
Sbjct: 964 DEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDES 1023
Query: 320 QNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEEL 379
K++ L + ER ++++ + ++ EK ++S Q++ + ++ + EK E EL
Sbjct: 1024 ---KKEIPLSETERGEVEEDK---ENKEYSEKCVTSKC-QEIEIYLKQTISEK---EVEL 1073
Query: 380 KQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQAT 439
+ +L++ EEQ + LVKQ+ + + + ++ LL+ ++ +A ++K ++T A+
Sbjct: 1074 QHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDAS 1133
Query: 440 LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
DS+ E V T S E K E L+EK K E +Q ++
Sbjct: 1134 -----DGDSVALVKETVVIS----PPCTGSS-EHWKPE---LEEKILALEKEKEQLQKKL 1180
Query: 500 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
+S K+ LK+ + KE L+ +LKQQ++D+ + E
Sbjct: 1181 QEALTSR------------KAILKKAQEKE---------RHLREELKQQKDDYNRLQEQF 1219
Query: 560 EGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAF-------EVEKQALLNEH 612
+ + E EN + +++ + ++ E + P Q ++ E +A H
Sbjct: 1220 DEQSKENEN----IGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHH 1275
Query: 613 GAAQEQLNKIRD------SYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKK 666
+ N D + L G ++ Q + +++ E +L+ +VS +L KK
Sbjct: 1276 TQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKK 1335
Query: 667 KQSETKLQEELNK 679
+ +LQE++NK
Sbjct: 1336 SEEVFQLQEQINK 1348
Score = 97.8 bits (242), Expect = 3e-20
Identities = 132/664 (19%), Positives = 289/664 (43%), Gaps = 62/664 (9%)
Query: 69 VKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKT 128
+K+ ++ E Q + D +I K+++V L E + I + ++++ +L AAL +
Sbjct: 1436 IKALHTQLEMQAKEHDERI--KQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRK 1493
Query: 129 SLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAK 188
N +L+++L T E L ++ +Q + +NK + + G +A
Sbjct: 1494 EALKENKSLQEELSLARGTIERLTKSLADVESQ----------VSAQNKEKDTVLGRLAL 1543
Query: 189 -QEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE-----EIS 242
QE + + RSL E+Q + E +++E D+ EKL++ IE +I+
Sbjct: 1544 LQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDK----EKLVKEIESLKSSKIA 1599
Query: 243 CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE 302
+++ EK+K ++ + E L + + + + + ++ + + ++ ++L K + E K+
Sbjct: 1600 ESTEWQEKHK-ELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKK 1658
Query: 303 DHVNRNREHNENLNAEMQNLKQKFILEQQER-----EKLQQKELQIDSLLQQEKELSSSL 357
+ + +E + + EM+ +KF +Q++ E+ + ++ KE +L
Sbjct: 1659 ETEKQLQEAEQEME-EMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETL 1717
Query: 358 HQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLE---------EEAK 408
S +EE+ + K +E K+ + + E+ + L Q+E E +
Sbjct: 1718 LSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATE 1777
Query: 409 SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT- 467
+ + EE + E E+ + E S + V+ F S+ +
Sbjct: 1778 KHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINN 1837
Query: 468 -ASEIEDLKLENSSLQEKAAK---AGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALK 523
+I+ LK + L+E+ K + E+ ++ +L+ S+ ++ML + TK L
Sbjct: 1838 YLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL 1897
Query: 524 ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 583
+I+E L ++T L+ +++++D ++L ++ AE + +++ ++
Sbjct: 1898 NQQIQE----ELSRVTKLKETAEEEKDDLEERLMNQ---LAELNGSIGNYCQDVTDAQIK 1950
Query: 584 YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVV 643
E L ++ K + + E EKQ L+ E + ++ K + K+ G Q H
Sbjct: 1951 NELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRK--EYLEKIQGAQKEPGNKSHAK 2008
Query: 644 KLKDENSQLKSEVSKLR--CQLAKKKQSETK--------LQEELNKVLGIKHFDPSKAFH 693
+L++ + + EV +L+ C ++K S + +Q E K L I + ++A
Sbjct: 2009 ELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE 2068
Query: 694 HESK 697
H K
Sbjct: 2069 HRKK 2072
Score = 94.0 bits (232), Expect = 4e-19
Identities = 153/730 (20%), Positives = 322/730 (44%), Gaps = 99/730 (13%)
Query: 45 KQQKESKQNLNVDKD---TTLPASARKVKSSESKKESQKNDKDLKIL---EKEIRVLLQE 98
+QQ+ QN + T L AS R++ S ++ + K K + +L E+ I+V + E
Sbjct: 2343 RQQEADIQNSKFSYEQLETDLQAS-RELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAE 2401
Query: 99 -RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSE 157
R D+ I++LE L + E N L E+ +K + + + E LK+ E
Sbjct: 2402 LRQQHDKEIKELENLLSQEEEE-NIVLEEEN---------KKAVDKTNQLMETLKTIKKE 2451
Query: 158 NGNQK-NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGK 216
N QK L + L+N R+ + +E + + ++E+ + +L+ +
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511
Query: 217 LVSIEKEKIDEKSETEKL----LEYIEEIS---CASDQVEKYKLDIAQLEENLKEKNDEI 269
+ + D SE KL ++Y E+++ D +K L++ QL++N KE ++
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEV-QLQQN-KELENKY 2569
Query: 270 LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 329
L++ L+E+ + EDL L++EK+D + E+L + L ++
Sbjct: 2570 AKLEEKLKES----EEANEDLRRSFNALQEEKQDL----SKEIESLKVSISQLTRQVTAL 2621
Query: 330 QQE--------REKLQQKEL-QIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELK 380
Q+E + K++++E+ ++ +L ++ + L ++L Q+E K+ E++LK
Sbjct: 2622 QEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLK 2681
Query: 381 QTLDELDK----LQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 436
+ L L ++ + E AE V +L + ++L ++ ++ KG A+++ + +
Sbjct: 2682 KELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMS 2741
Query: 437 QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV- 495
LQ D + L+++ ++++ + E+ LK + +E+ A + A +
Sbjct: 2742 S----LQNSRDHANEELDELKRKYDA----SLKELAQLKEQGLLNRERDALLSETAFSMN 2793
Query: 496 ---QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ---LKQQE 549
++ + E NQ+ + L S+ E ++ SF + + LQN+ L +
Sbjct: 2794 STEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQ-SFSKAMASLQNERDHLWNEL 2852
Query: 550 EDFRKQLEDEEGRKAEKENTTAE-----------------LTEEINKWRLLYEEL---YN 589
E FRK E ++ A+ + AE L +E+ + Y ++
Sbjct: 2853 EKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEIT 2912
Query: 590 KTKPFQLQLD-------AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHV 642
+ P + QL AF++ ++ L E+ + Q +L+++R + H+ + K +++
Sbjct: 2913 ELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHER-RMKEQYL 2971
Query: 643 VKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFAL 702
+ + D++ QL S L+ + + + S ++ Q KV + P + + +N
Sbjct: 2972 MAISDKDQQL----SHLQNLIRELRSSSSQTQP--LKVQYQRQASPETSASPDGSQNLVY 3025
Query: 703 KTPLKEGNTN 712
+T L N
Sbjct: 3026 ETELLRTQLN 3035
Score = 92.4 bits (228), Expect = 1e-18
Identities = 159/683 (23%), Positives = 294/683 (43%), Gaps = 68/683 (9%)
Query: 27 KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLK 86
K LE+ K ++ R K Q E + DT A+ + + KKE Q N + +K
Sbjct: 2054 KDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK 2113
Query: 87 ILEKEIRVLLQER--GAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIEL 144
K+ L+ R A+++ +++ + EK++A + + ++ TL K+ E+
Sbjct: 2114 SQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEV 2173
Query: 145 TRTNELLKSKFSE----NGNQKNLRILSLELMKLRNKRETKMR-GMMAKQEGMEMK---L 196
+ E L S ++ + +L+ ++ K E K + +K+E + +K
Sbjct: 2174 QQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNC 2233
Query: 197 QVTQRSLEESQGKIAQLEGKLVSIEKEK--IDEKSETEKLLEYIEEISCASDQVEKYKLD 254
V + L + + +L+ + +E +K + K++TE L ++ C + Q E +L
Sbjct: 2234 SVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQL---QQKVCDTLQGENKEL- 2289
Query: 255 IAQLEE--NLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN 312
++QLEE +L + L+ LE + L Q+ DL+ LEK KE N
Sbjct: 2290 LSQLEETRHLYHSSQNELA---KLESELKSLKDQLTDLS---NSLEKCKEQKGNLEGIIR 2343
Query: 313 ENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEK 372
+ A++QN KF EQ E + LQ +EL+S LH+++ +++++
Sbjct: 2344 QQ-EADIQN--SKFSYEQLETD------------LQASRELTSRLHEEINMKEQKIISLL 2388
Query: 373 NLFEEELKQTLDELDKLQQKE-EQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS 431
+ EE ++ + EL + KE ++ E L+ Q EEE EE K +K L+
Sbjct: 2389 SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTI 2448
Query: 432 SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKN 491
+ Q L SM D Y+ L + + ++ +QE AA+ K
Sbjct: 2449 KKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKL 2508
Query: 492 AEDVQHQILATESSNQEYVRMLLDL-QTKSALKETEIKEITVSFLQKITDLQNQLKQQEE 550
E+++ + N E ++ +L Q + L + IT+ Q+ L+ QL+Q
Sbjct: 2509 KEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQV----ITIKDSQQKQLLEVQLQQ--- 2561
Query: 551 DFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLN 610
K+LE++ + EK + E E++ R + L + + ++++ +V L
Sbjct: 2562 --NKELENKYAKLEEKLKESEEANEDL---RRSFNALQEEKQDLSKEIESLKVSISQLTR 2616
Query: 611 EHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQL------A 664
+ A QE+ L H LK K + V +L S + +++L +L A
Sbjct: 2617 QVTALQEE-------GTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEA 2669
Query: 665 KKKQSETKLQEELNKVLGIKHFD 687
KK E ++++L K L H D
Sbjct: 2670 AKKVGE--IEDKLKKELKHLHHD 2690
Score = 90.5 bits (223), Expect = 5e-18
Identities = 149/732 (20%), Positives = 294/732 (40%), Gaps = 71/732 (9%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKN--- 81
D+ E+ + QK ++ + K+T + + S K E ++
Sbjct: 1109 DLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILA 1168
Query: 82 -DKDLKILEKEIRVLLQERGAQDRRIQD----LETELEKMEARLNAALREKTSLSANNAT 136
+K+ + L+K+++ L R A ++ Q+ L EL++ + N + S N
Sbjct: 1169 LEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENEN 1228
Query: 137 LEKQLIELT-RTNELLKSKFSENGNQKNLRIL-SLELMKLRNKRETKMRGMMAKQEGMEM 194
+ QL +L + E + K Q++ LE + + + ++ +
Sbjct: 1229 IGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDW 1288
Query: 195 KLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEK----SETEKLLEYIEEISCASDQVEK 250
S + +AQ++ +L IE EK++ + S T +L + EE+ +Q+ K
Sbjct: 1289 PSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINK 1348
Query: 251 YKLDIAQLEENLKEKNDEILSLKQSLEENIVILS--KQVEDLNVKCQLLEK---EKEDHV 305
L+I L+ E SL+Q LE + + ++ + + +L K L+K +KE+ V
Sbjct: 1349 QGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDV 1408
Query: 306 NRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQ 365
+ A + ++ + I+EQ++ K +L++ + ++ E L +LC +
Sbjct: 1409 SYLSGQLSEKEAALTKIQTE-IIEQEDLIKALHTQLEMQA--KEHDERIKQLQVELCEMK 1465
Query: 366 EEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLE---EKLK 422
++ EE+ + ++Q+K + A K+ +E KS EEL L E+L
Sbjct: 1466 QK--------PEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLT 1517
Query: 423 GKEAELEKSSAAHTQAT-------LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK 475
A++E +A + LLQE+ D ++ ++ + +S +S E LK
Sbjct: 1518 KSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL----SSSCESLK 1573
Query: 476 LENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIK----EIT 531
L L E K K E ++ +A + QE + K KE EI E
Sbjct: 1574 LALEGLTEDKEKLVKEIESLKSSKIAESTEWQE--------KHKELQKEYEILLQSYENV 1625
Query: 532 VSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKT 591
+ ++I + ++Q++++ +L E K E E E +E+ + + E++
Sbjct: 1626 SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMK---EKMRKFA 1682
Query: 592 KPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQ 651
K Q ++ E E L E A + + ++ + +K+E +
Sbjct: 1683 KSKQQKILELEEENDRLRAEVHPAGDTAKECMETL------------LSSNASMKEELER 1730
Query: 652 LKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNT 711
+K E L + + L EE+ + + SK + E+ E +T + E T
Sbjct: 1731 VKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGT 1790
Query: 712 NCYRAPMECQES 723
E Q+S
Sbjct: 1791 QSIPGETEEQDS 1802
Score = 76.3 bits (186), Expect = 1e-13
Identities = 122/607 (20%), Positives = 251/607 (41%), Gaps = 60/607 (9%)
Query: 26 VKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDL 85
VK EV + F SQ+ + E ++ + V K+ +A+KV E K + K+L
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELE-EELVCVQKE-----AAKKVGEIEDKLK-----KEL 2684
Query: 86 KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELT 145
K L + ++ E + R+ +L +L +ME +L +E L+A + + + L
Sbjct: 2685 KHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQ 2744
Query: 146 RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 205
+ + + E + + L+ + K +G++ ++ + L T S+
Sbjct: 2745 NSRDHANEELDELKRKYDA--------SLKELAQLKEQGLLNRER--DALLSETAFSMNS 2794
Query: 206 SQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK 265
++ E L +EK S+ E+LL ++ + +QV+ + +A L+
Sbjct: 2795 TE------ENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHL 2848
Query: 266 NDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQK 325
+E+ ++S EE + Q + Q L+K N + L E++NL+Q+
Sbjct: 2849 WNELEKFRKS-EEGKQRSAAQPSTSPAEVQSLKKAMSSLQN----DRDRLLKELKNLQQQ 2903
Query: 326 FILEQQEREKLQQKELQIDSLLQQEKE---LSSSLHQKLCSFQEEMVK---EKNLFE-EE 378
++ QE +L + Q+ + K + L Q+ S+Q E+ + EK+ +E E
Sbjct: 2904 YLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHE 2963
Query: 379 LKQTLDELDKLQQKEEQAERLVKQLEE--EAKSRAEELKLLEEKLKGKEAELEKSSAAH- 435
+ L + K++Q L + E + S+ + LK+ ++ E + +
Sbjct: 2964 RRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNL 3023
Query: 436 TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAE-- 493
T LL+ + + ++ + + + + + +E+ + L + + +N +
Sbjct: 3024 VYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHY 3083
Query: 494 -DVQHQILATESSNQEYVRMLLDL-------QTKSALKETEIKEITVSFLQKITDLQNQL 545
D+ + E QE L++ Q K+ + E Q ++ Q QL
Sbjct: 3084 GDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQL 3143
Query: 546 ---KQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFE 602
+Q+ + RK LE+E ++ EN + E+I RL + E + P + +
Sbjct: 3144 CNTRQEVNELRKLLEEERDQRVAAENALSVAEEQIR--RLEHSEWDSSRTPI---IGSCG 3198
Query: 603 VEKQALL 609
++QALL
Sbjct: 3199 TQEQALL 3205
Score = 72.0 bits (175), Expect = 2e-12
Identities = 159/780 (20%), Positives = 314/780 (40%), Gaps = 138/780 (17%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
Q S ++ KQ L +K+ + ++ +++++ +Q+ + EK+ R Q
Sbjct: 177 QSSTEMEEFVMMKQQLQ-EKEEFISTLQAQLSQTQAEQAAQQ-----VVREKDARFETQV 230
Query: 99 RGAQDRRIQ-----DLETELEKMEARLNAALREKTSLSANNAT----LEKQLIELTRTNE 149
R +D +Q D+ETE+++ L L E A L+++L + N+
Sbjct: 231 RLHEDELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQ 290
Query: 150 LLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGK 209
+L + + + N LRN ET+ E ME+++ + S Q +
Sbjct: 291 ILSQQLQQMEAEHNT---------LRNTVETEREESKILLEKMELEVAERKLSFHNLQEE 341
Query: 210 I--------------AQLEGKLVSIE-KEKIDEKSETEKLLEYI---EEISCASDQVEKY 251
+ A+LE + ++E K K + + +T +L +E+ A D ++
Sbjct: 342 MHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKD- 400
Query: 252 KLDIAQLEENLKEKNDEILSLKQS---LEENIVILSKQVEDLNVKCQLLEKEKEDHVNRN 308
Q + L++KN++ + Q+ LE+ + SK++ + L + E +
Sbjct: 401 -----QNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFP 455
Query: 309 REHNENLNA----EMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLH----QK 360
+NE A + +L+++ + + E+ L ++++ L + ++LSS + Q
Sbjct: 456 DVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQN 515
Query: 361 LCSFQEEMVKEKNLFEEELKQTLDE----LDKLQQKEEQAERLVKQLEEEAKSRAEELKL 416
+ V E ++ + K++ D L+ Q + + L E K EE+
Sbjct: 516 RTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAF 575
Query: 417 LEEKLKGKEAE--------------LEKSSAAHTQATLLLQE---------KYDSMVQSL 453
L+ +L+GK AE +E A + + L++ +S + ++
Sbjct: 576 LKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNEESSLPAV 635
Query: 454 EDVTAQFESYKALTASEI--EDLKLENSSLQEKAAKAGKNAEDV-----------QHQIL 500
E A E +++ T+ EI D +E S ++ K+ D+ + QIL
Sbjct: 636 EKEQASTE-HQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQIL 694
Query: 501 ATE---SSNQEYVRMLLDLQTK-----------------------SALKETEIKEIT-VS 533
E QE LD + K +AL E + ++ V
Sbjct: 695 ELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVK 754
Query: 534 FLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAE---LTEEINKWRLLYEELYNK 590
L +T+L+ Q+KQ E + E E R+ + E+ TA LTE+I+ + + K
Sbjct: 755 ELSMVTELRAQVKQLEMNL---AEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVK 811
Query: 591 TKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENS 650
+ Q +LD +++ + Q QL L G + ++ V +L S
Sbjct: 812 IEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEV--LEGAERVRHISSKVEELSQALS 869
Query: 651 QLKSEVSKLRCQLAKKKQSETKLQ---EELNKVLGIKHFDPSKAFHHESKENFALKTPLK 707
Q + E++K+ L +KK+ LQ EE ++ + F ++ ++E F+L +K
Sbjct: 870 QKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIK 929
Score = 70.5 bits (171), Expect = 5e-12
Identities = 121/569 (21%), Positives = 246/569 (43%), Gaps = 98/569 (17%)
Query: 83 KDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI 142
KD+++ +K+ L +ER A D +I+ L K+ A+
Sbjct: 71 KDVQLQQKD-EALQEERKAADNKIKKL-----KLHAKA---------------------- 102
Query: 143 ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 202
+LT N+ ++ ++ G S E + +K T+ EM+++ +
Sbjct: 103 KLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE----------EMEIEKIKHK 152
Query: 203 LEESQGKIAQLEGKLVSIEKEKIDEKSE--------TEKLLEYIEEISCASDQVEKYKLD 254
L+E + I+ L+ +L + E+ + S ++L E E IS Q+ + + +
Sbjct: 153 LQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAE 212
Query: 255 IAQLEENLKEKNDEILSLKQSLEENIVILSKQVE---DLNVKCQLLEKEKEDHVNRNREH 311
A ++ ++EK+ + + E+ ++ L Q + ++ K ++L+++ E EH
Sbjct: 213 QA-AQQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRKLE-------EH 264
Query: 312 NENL--NAEMQNLKQKFILEQQER-----EKLQQKELQIDSL---LQQEKELSSSLHQKL 361
E+L A++ +L Q+ + ++R ++LQQ E + ++L ++ E+E S L +K+
Sbjct: 265 EESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKM 324
Query: 362 CSFQEEMVKEKNL----FEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL 417
E V E+ L +EE+ L++ ++ Q + + E LE++ K+ EE
Sbjct: 325 ----ELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSH 380
Query: 418 EEKLKGKEAELEKS-SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKL 476
L+ EL+ + A Q + LLQ+K + VQS + + Q E + EI L
Sbjct: 381 ILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTI-QQLEDQLQQKSKEISQF-L 438
Query: 477 ENSSLQEKAAKAGKNAEDVQHQ--ILATESSNQEYVRMLLDLQTK------SALKETEIK 528
LQ+ + + DV ++ TE + + +++L+ + S+++ E+K
Sbjct: 439 NRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELK 498
Query: 529 EITVSFLQKITDLQNQLKQQEED------------FRKQLEDEEGRKAEKENTTAELTEE 576
+IT L+ Q + E D ++ EE + ENT ++ +E
Sbjct: 499 AENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKE 558
Query: 577 INKWRLLYEELYNKTKPFQLQLDAFEVEK 605
++ L +E + +LQL E+
Sbjct: 559 LSVLLLEMKEAQEEIAFLKLQLQGKRAEE 587
Score = 70.1 bits (170), Expect = 7e-12
Identities = 83/418 (19%), Positives = 182/418 (43%), Gaps = 24/418 (5%)
Query: 302 EDHVNRNREHNENLNAEMQNL-KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
++ V + E L E++++ +QK + QQ+ E LQ++ D+ +++ K + +
Sbjct: 47 QEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTS 106
Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
L + EEM + Q+ ++L K + + E +++++ + + + E + L+ +
Sbjct: 107 LNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQ 166
Query: 421 LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSS 480
L +AE S+ + ++++++ + + + AQ +A A++
Sbjct: 167 LTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQ--------QV 218
Query: 481 LQEKAAKAGKNA---EDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK 537
++EK A+ ED Q++ E + L LQ K L+E E E V Q
Sbjct: 219 VREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVLQRK--LEEHE--ESLVGRAQV 274
Query: 538 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK--WRLLYEELYNKTKPFQ 595
+ LQ +L E+ R Q+ ++ ++ E E+ T T E + ++L E++ + +
Sbjct: 275 VDLLQQELTAAEQ--RNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERK 332
Query: 596 LQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKL--LGHQNLKQKIKHVVKLKDENSQLK 653
L + E LL + A + ++ Y+ L +++K H++ L+ +L+
Sbjct: 333 LSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQ 392
Query: 654 SEVSKLRCQLAKKKQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKEGNT 711
S L+ Q +K Q K ++ + I+ + + F + PL++ T
Sbjct: 393 SACDALKDQNSKLLQD--KNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 116 bits (290), Expect = 8e-26
Identities = 158/673 (23%), Positives = 300/673 (44%), Gaps = 94/673 (13%)
Query: 75 KKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEK----MEARLNAALRE---- 126
K E ++ + I +I L E G Q R ++ +++EK ++ R+N R+
Sbjct: 446 KDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRINEYQRKAEQE 505
Query: 127 ---KTSLSANNATLEKQLIEL---TRTNELLKSKFSENGNQKN-----LRILSLELMKLR 175
+ ++ +TL+ QL +L ++ ++L K S+ Q LR S ++LR
Sbjct: 506 NEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRTESDTAVRLR 565
Query: 176 NKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSI-EKEKIDEKSETEKL 234
K T+M +++ E + +LQ R LE S+ + + +L +I E E+ D ++E +
Sbjct: 566 -KSHTEMSKSISQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHDSEMI 624
Query: 235 LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKC 294
+ I+ ++V+ K ++ ++E KE D +L+ + + N+ I DLN K
Sbjct: 625 GDLQARITSLQEEVKHLKHNLEKVEGERKEAQD-MLNHSEKEKNNLEI------DLNYKL 677
Query: 295 QLLEKEKEDHVNRNREHNENLNAEMQNLKQ-----------KFILEQQEREKLQQKELQI 343
+ L++ E VN ++ L + Q++++ K E++ REK + + +QI
Sbjct: 678 KSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQI 737
Query: 344 D---SLLQQEKELSSSLHQKLCSFQEEMVKE-KNL-------------FEEELKQTLDEL 386
+ S+L + + S + L +E M E KNL + ELK E
Sbjct: 738 EKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEA 797
Query: 387 DKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKY 446
D L+ E+Q ++ + L E + EL L ++ +G E ++ + +A Y
Sbjct: 798 DNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQM-RELQDQLEAEQYFSTLY 856
Query: 447 DSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSN 506
+ V+ L++ + E +I++L+ E +L + A AE Q LA
Sbjct: 857 KTQVKELKE---EIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQ---LARGLLE 910
Query: 507 QEYVRMLLDLQTKSALKETEI--KEITVSFLQKIT-----DLQNQLKQQEEDFRKQLEDE 559
++Y + + + ++ EI K+ TVS L++ D++ ++ EE K + E
Sbjct: 911 EQYFELTQESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEILRRENEELTEKMKKAE 970
Query: 560 EGRKAEKE----NTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQAL------- 608
E K EKE N A + IN R L + NK + D F+++++
Sbjct: 971 EEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKD-FKIDRKKANTQDLRK 1029
Query: 609 -LNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEV---SKLRCQLA 664
E+ Q +LN+ R+ + +++ +KH +L D +QL E ++L+ QLA
Sbjct: 1030 KEKENRKLQLELNQEREKFNQMV--------VKHQKELNDMQAQLVEECAHRNELQMQLA 1081
Query: 665 KKKQSETKLQEEL 677
K+ +L+ +L
Sbjct: 1082 SKESDIEQLRAKL 1094
Score = 57.0 bits (136), Expect = 6e-08
Identities = 75/340 (22%), Positives = 153/340 (45%), Gaps = 42/340 (12%)
Query: 363 SFQEEMVKEKNLFEEELKQTLDELDKLQQK----EEQAERLVKQLEEEAKSRAEELKLLE 418
S QE + K EE+L + D+++QK + ++++K+L+EE R
Sbjct: 423 SLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQR-------- 474
Query: 419 EKLKGKEAELEKSSAAHTQATLLLQEK---YDSMVQSLEDVTAQFESYKALTASEIEDLK 475
L+ +++EK +LLQ + Y + + E+ + ++EDLK
Sbjct: 475 RNLESTVSQIEKEK-------MLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLK 527
Query: 476 --LENSSL-QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITV 532
+NS L EK ++ K E+ + +L TES +R +KS ++++ +
Sbjct: 528 KVSQNSQLANEKLSQLQKQLEEA-NDLLRTESDTAVRLRKSHTEMSKSI---SQLESLNR 583
Query: 533 SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 592
++ L+N Q ++D+ + E + ++ + +E I + L + K
Sbjct: 584 ELQERNRILENSKSQTDKDYYQLQAILEAERRDRGHD----SEMIGDLQARITSLQEEVK 639
Query: 593 PFQLQLDAFEVEK---QALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKI-KHVV---KL 645
+ L+ E E+ Q +LN H ++ +I +Y Q L+Q++ +H V +L
Sbjct: 640 HLKHNLEKVEGERKEAQDMLN-HSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARL 698
Query: 646 KDENSQLKSEVSKLRCQLAKKKQSETKLQEEL-NKVLGIK 684
D++ ++ S C++ KK + E + +E+ N+V+ I+
Sbjct: 699 TDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVQIE 738
Score = 48.9 bits (115), Expect = 2e-05
Identities = 49/241 (20%), Positives = 113/241 (46%), Gaps = 9/241 (3%)
Query: 90 KEIRVLLQERGAQD-RRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
KE++ ++E+ ++ ++IQ+L+ E E + +L+ A + S LE+Q ELT+ +
Sbjct: 861 KELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQES 920
Query: 149 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
+ S+ + K+ + LE ++ + + ++E E+ ++ + E
Sbjct: 921 KKAASRNRQEITDKDHTVSRLEEANSMLTKDIE----ILRRENEELTEKMKKAEEEYKLE 976
Query: 209 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASD-QVEKYKLDIAQLEENLKEKND 267
K ++ + EK E++ + + + EI D ++++ K + L + KE
Sbjct: 977 KEEEISNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRK 1036
Query: 268 EILSLKQSLEE-NIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKF 326
L L Q E+ N +++ Q E +++ QL+E+ H N + + ++++ L+ K
Sbjct: 1037 LQLELNQEREKFNQMVVKHQKELNDMQAQLVEECA--HRNELQMQLASKESDIEQLRAKL 1094
Query: 327 I 327
+
Sbjct: 1095 L 1095
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 116 bits (290), Expect = 8e-26
Identities = 137/564 (24%), Positives = 266/564 (47%), Gaps = 86/564 (15%)
Query: 172 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
MKL K + ++ ++E MK Q + L +S+ K +LE K+V++ KEK D +
Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 230 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 282
+ + E + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 283 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK--- 339
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 956 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 340 ----------------------ELQIDSL---LQQEKELSSSLHQK-------LCSFQEE 367
E Q+D L L+QEK+L L + L QE
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 368 MV---KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 424
++ EK +E+LK+ E+ LQ K E + L QL+++ K ++ LEE+++ +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 425 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK--LENSSLQ 482
A K+ + + L+E + + ++ +AQ E K A E + ++ LE ++LQ
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEATLQ 1190
Query: 483 EKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 539
+A A K+A+ V L + N + V+ L+ + KS +K EI ++ S ++ ++
Sbjct: 1191 HEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLE-KEKSEMK-MEIDDL-ASNVETVS 1245
Query: 540 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 599
+ L++ QL + + ++ E++ +LT + + L ++ F QLD
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR-------LQTESGEFSRQLD 1298
Query: 600 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSE 655
EK+AL++ QL++ + ++ + + + LK++++ +K K+ + + +
Sbjct: 1299 ----EKEALVS-------QLSRGKQAFTQQI--EELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 656 VSKLRCQLAKKKQSETKLQEELNK 679
LR Q ++++S+ +LQ L+K
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK 1369
Score = 106 bits (264), Expect = 9e-23
Identities = 153/705 (21%), Positives = 314/705 (44%), Gaps = 93/705 (13%)
Query: 42 QRFKQQKE---SKQNLNVDKDTTLPASARKVKSSESKKESQKNDK--DLKILEKEIRVLL 96
QR KQ+ E S+ + +D + + K K + K D+ +LK E+E + L+
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 97 QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
+ AQ R+Q + +L++ EA ++ R K + + L++QL E +
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336
Query: 149 ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 193
+LL+ ++ E Q+ L + E+ + R K ET + +E E
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD--AIQRTEELEE 1394
Query: 194 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
K ++ QR L+ ++ + + K S+EK K ++E E L+ +E + A ++K +
Sbjct: 1395 AKKKLAQR-LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 254 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
+ ++ K+K +E + ++ ++ L ++ K + +E D + + N+
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTEL----FKIKNAYEESLDQLETLKRENK 1509
Query: 314 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 373
NL E+ +L ++ + +L++ + Q++ Q++ EL ++L + S + E K
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKCELQAALEEAEASLEHEEGKILR 1566
Query: 374 LFEEELKQTLDELD-KLQQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEEKL 421
+ + EL Q E+D K+ +K+E+ ++L + L+ E +SR + ++L ++K+
Sbjct: 1567 I-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL-KKKM 1624
Query: 422 KG--KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENS 479
+G E E++ + A A L Y + L+D + AL + E DLK + +
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEAL--RNYRNTQGILKDTQIHLDD--ALRSQE--DLKEQLA 1678
Query: 480 SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 539
++ +A E+++ + TE S + + LLD + L T+ + + + T
Sbjct: 1679 MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET 1738
Query: 540 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTK 592
D+ +Q++ + ED ++ + E + + A + EE+ K + + + K
Sbjct: 1739 DI-SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797
Query: 593 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK---------IKHVV 643
QL+LD E E+ AL ++Q+ K+ +L G +QK KH
Sbjct: 1798 DLQLRLD--EAEQLAL----KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851
Query: 644 KLKDENSQ----------LKSEVSKLRCQLAKKKQSETKLQEELN 678
++K+ Q L+ V KL+ ++ K+ + +E+ N
Sbjct: 1852 RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896
Score = 105 bits (263), Expect = 1e-22
Identities = 139/665 (20%), Positives = 285/665 (42%), Gaps = 62/665 (9%)
Query: 68 KVKSSESKKESQKNDKDLKILEKEI----RVLLQERGAQDRRIQDLETELEKMEARLNAA 123
K++ KE + +D + + E+ R L E + I DLE L K+E +A
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977
Query: 124 LREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR 183
+ +L+ A L++ + +LT+ + L + +Q+ L L E K+ + K++
Sbjct: 978 ENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQAEEDKVNTLTKAKIK 1032
Query: 184 ---------GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL 234
G + +++ + M L+ +R L E K+AQ + EK+++DEK + ++
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKL-EGDLKLAQESIMDIENEKQQLDEKLKKKEF 1091
Query: 235 LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE---ENIVILSKQVEDLN 291
EIS ++E + QL++ +KE I L++ +E + KQ DL+
Sbjct: 1092 -----EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 292 VKCQLLEKEKED---HVNRNREHNENLNAEMQNLKQKF------------ILEQQEREKL 336
+ + + + E+ + E N+ AE Q +++ L ++ + +
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 337 QQKELQIDSL------LQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQ 390
+ QID+L L++EK L S E + K K E+ + D+L +L+
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 391 QKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA---ELEKSSAAHTQATLLLQEKYD 447
KEE+ +RL+ L + E +L KEA +L + A TQ L+ + +
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE 1326
Query: 448 SMVQSLEDVTAQFESYK---ALTASEIEDLKLENSSLQEKAAKAGKNAED--VQHQILAT 502
+++ + +S + L + E+ + + LQ +KA +++ A
Sbjct: 1327 EEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAI 1386
Query: 503 ESSNQ-EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 561
+ + + E + L + ++A + E + L+K + +L+ + ED +E
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK---TKQRLQNEVEDLMLDVERTNA 1443
Query: 562 RKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK 621
A + + + +W+ EE + + + Q + + E + N + + +QL
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET 1503
Query: 622 IRDSYAKLLGH-QNLKQKIKHVVKLKDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNK 679
++ L +L ++I K E ++K +V + +C+L A +++E L+ E K
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563
Query: 680 VLGIK 684
+L I+
Sbjct: 1564 ILRIQ 1568
Score = 104 bits (259), Expect = 3e-22
Identities = 140/696 (20%), Positives = 295/696 (42%), Gaps = 91/696 (13%)
Query: 45 KQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDR 104
+Q+K+ + +L K L + + S E++K D K+ +KE + + +D
Sbjct: 1045 EQEKKLRMDLERAK-RKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE 1103
Query: 105 RIQ--DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 162
+ L+ ++++++AR+ E + A+ A EKQ +L+R E + + E G
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1163
Query: 163 NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG--------KIAQLE 214
+ +I ++ KRE + + M E ++ + T +L + +I L+
Sbjct: 1164 SAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1217
Query: 215 GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 274
+EKEK + K E + L +E +S A +EK + D++ LK
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKM----------CRTLEDQLSELKS 1267
Query: 275 SLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQERE 334
EE + + DL + L+ E + +R + E L +++ KQ F + +E +
Sbjct: 1268 KEEEQ----QRLINDLTAQRGRLQTESGEF-SRQLDEKEALVSQLSRGKQAFTQQIEELK 1322
Query: 335 KLQQKELQIDSLL------------------QQEKELSSSLHQKLCSFQEEMVKEKNLFE 376
+ ++E++ + L ++E+E + L + L E+ + + +E
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYE 1382
Query: 377 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 436
+ Q +EL++ ++K Q + ++ E ++ L+ +++L+ + +L
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 437 QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 496
A L +K ++ + + A+++ T +E+E + E SL + K E+
Sbjct: 1443 AACAALDKKQ----RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESL 1498
Query: 497 HQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQL 556
Q+ + N+ + + DL + A I E+ +++ + +L+ E+ L
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVEQEKCELQAALEEAEASL 1557
Query: 557 EDEEGR-----------KAEKENTTAELTEEINKWR------------LLYEELYNKTKP 593
E EEG+ K+E + AE EEI++ + L E+ ++
Sbjct: 1558 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDA 1617
Query: 594 FQLQL----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDE 648
+L+ D E+E Q L + + A E L R++ L Q +L ++ LK++
Sbjct: 1618 IRLKKKMEGDLNEMEIQ-LNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ 1676
Query: 649 NSQ-------LKSEVSKLRCQLAKKKQSETKLQEEL 677
+ L++E+ +LR L + ++S ++EL
Sbjct: 1677 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL 1712
Score = 72.8 bits (177), Expect = 1e-12
Identities = 93/435 (21%), Positives = 189/435 (43%), Gaps = 54/435 (12%)
Query: 22 GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKKESQ 79
G + LE +K V +K + +E++ +L ++ L +VKS +K ++
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1584
Query: 80 KNDKDLKILEKEIRVLLQERGAQDRRIQD----------LETELEKMEARLNAALREKTS 129
K+++ ++ IR++ + D I+ +E +L +ME +LN A R
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644
Query: 130 LSANNATLEK-------QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TK 181
N + L + R+ E LK + + + NL L E+ +LR E T+
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTE 1702
Query: 182 MRGMMAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
+A+QE ++ +V T++ LE I+Q++G++ I +E ++
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQMQGEMEDILQEA---RN 1756
Query: 230 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SK 285
EK + I + + +++++K + A LE K + L+ L+E + K
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 286 QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 345
Q++ L + + LE E E RN E + L + +K+ +++R+ + + + +D
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876
Query: 346 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 405
L + K EE ++ N + ++ EL++ +++ + AE V +L
Sbjct: 1877 LQAKVKSYKRQ--------AEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL-- 1926
Query: 406 EAKSRAEELKLLEEK 420
KSR K++ E+
Sbjct: 1927 RVKSREVHTKVISEE 1941
Score = 70.5 bits (171), Expect = 5e-12
Identities = 95/441 (21%), Positives = 197/441 (44%), Gaps = 70/441 (15%)
Query: 68 KVKSS--ESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLET---ELEKMEARLNA 122
K+K++ ES + + ++ K L++EI L ++ +RI +LE ++E+ + L A
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548
Query: 123 ALRE-KTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ----KNLRILSLELMKLRNK 177
AL E + SL + + +EL + + K +E + K I +E M+
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608
Query: 178 RETKMRG----MMAKQEG--MEMKLQV-----------------------TQRSLEESQG 208
E + R + K EG EM++Q+ TQ L+++
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668
Query: 209 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
L+ +L +E+ ++E E+L +E+ + E+ LD ++ + L +N
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728
Query: 269 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAE 318
+++ K+ LE +I + ++ED+ + + E++ + + + + ++ + +L
Sbjct: 1729 LINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1788
Query: 319 MQNLKQ-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSF 364
+N++Q + L++ E+ L+ + QI L + +EL + K
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK 1848
Query: 365 QEEMVKEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
E VKE EE ++ + D +DKLQ K + +R ++ EE++ + + + L+ +
Sbjct: 1849 HERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHE 1908
Query: 421 LKGKEAELEKSSAAHTQATLL 441
L +EAE E++ A +Q L
Sbjct: 1909 L--EEAE-ERADIAESQVNKL 1926
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 116 bits (290), Expect = 8e-26
Identities = 137/564 (24%), Positives = 266/564 (47%), Gaps = 86/564 (15%)
Query: 172 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
MKL K + ++ ++E MK Q + L +S+ K +LE K+V++ KEK D +
Sbjct: 836 MKLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQL 895
Query: 230 ETEKLLEYIEEISCASDQVEKYKL-------DIAQLEENLKEKNDEILSLKQSLEENIVI 282
+ + E + + DQ+ K K+ ++ + E+ +E N E+ + K+ LE+
Sbjct: 896 QVQAEAEGLADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSE 955
Query: 283 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQK--- 339
L K ++DL + +EKEK H N+ +NL EM L + +E++ LQ+
Sbjct: 956 LKKDIDDLELTLAKVEKEK--HATENKV--KNLTEEMAGLDETIAKLTKEKKALQEAHQQ 1011
Query: 340 ----------------------ELQIDSL---LQQEKELSSSLHQK-------LCSFQEE 367
E Q+D L L+QEK+L L + L QE
Sbjct: 1012 TLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQES 1071
Query: 368 MV---KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 424
++ EK +E+LK+ E+ LQ K E + L QL+++ K ++ LEE+++ +
Sbjct: 1072 IMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAE 1131
Query: 425 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK--LENSSLQ 482
A K+ + + L+E + + ++ +AQ E K A E + ++ LE ++LQ
Sbjct: 1132 RASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREA-EFQKMRRDLEEATLQ 1190
Query: 483 EKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 539
+A A K+A+ V L + N + V+ L+ + KS +K EI ++ S ++ ++
Sbjct: 1191 HEATAATLRKKHADSVAE--LGEQIDNLQRVKQKLE-KEKSEMK-MEIDDL-ASNVETVS 1245
Query: 540 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLD 599
+ L++ QL + + ++ E++ +LT + + L ++ F QLD
Sbjct: 1246 KAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGR-------LQTESGEFSRQLD 1298
Query: 600 AFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL----KSE 655
EK+AL++ QL++ + ++ + + + LK++++ +K K+ + + +
Sbjct: 1299 ----EKEALVS-------QLSRGKQAFTQQI--EELKRQLEEEIKAKNALAHALQSSRHD 1345
Query: 656 VSKLRCQLAKKKQSETKLQEELNK 679
LR Q ++++S+ +LQ L+K
Sbjct: 1346 CDLLREQYEEEQESKAELQRALSK 1369
Score = 106 bits (264), Expect = 9e-23
Identities = 153/705 (21%), Positives = 314/705 (44%), Gaps = 93/705 (13%)
Query: 42 QRFKQQKE---SKQNLNVDKDTTLPASARKVKSSESKKESQKNDK--DLKILEKEIRVLL 96
QR KQ+ E S+ + +D + + K K + K D+ +LK E+E + L+
Sbjct: 1217 QRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLI 1276
Query: 97 QERGAQDRRIQ----DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN---- 148
+ AQ R+Q + +L++ EA ++ R K + + L++QL E +
Sbjct: 1277 NDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALA 1336
Query: 149 ----------ELLKSKFSENGN-----QKNLRILSLELMKLRNKRETKMRGMMAKQEGME 193
+LL+ ++ E Q+ L + E+ + R K ET + +E E
Sbjct: 1337 HALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETD--AIQRTEELEE 1394
Query: 194 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
K ++ QR L+ ++ + + K S+EK K ++E E L+ +E + A ++K +
Sbjct: 1395 AKKKLAQR-LQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQR 1453
Query: 254 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
+ ++ K+K +E + ++ ++ L ++ K + +E D + + N+
Sbjct: 1454 NFDKILAEWKQKCEETHAELEASQKEARSLGTEL----FKIKNAYEESLDQLETLKRENK 1509
Query: 314 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 373
NL E+ +L ++ + +L++ + Q++ Q++ EL ++L + S + E K
Sbjct: 1510 NLQQEISDLTEQIAEGGKRIHELEKIKKQVE---QEKCELQAALEEAEASLEHEEGKILR 1566
Query: 374 LFEEELKQTLDELD-KLQQKEEQAERLVKQ-----------LEEEAKSRAEELKLLEEKL 421
+ + EL Q E+D K+ +K+E+ ++L + L+ E +SR + ++L ++K+
Sbjct: 1567 I-QLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL-KKKM 1624
Query: 422 KG--KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENS 479
+G E E++ + A A L Y + L+D + AL + E DLK + +
Sbjct: 1625 EGDLNEMEIQLNHANRMAAEAL--RNYRNTQGILKDTQIHLDD--ALRSQE--DLKEQLA 1678
Query: 480 SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKIT 539
++ +A E+++ + TE S + + LLD + L T+ + + + T
Sbjct: 1679 MVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLET 1738
Query: 540 DLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK-------WRLLYEELYNKTK 592
D+ +Q++ + ED ++ + E + + A + EE+ K + + + K
Sbjct: 1739 DI-SQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVK 1797
Query: 593 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQK---------IKHVV 643
QL+LD E E+ AL ++Q+ K+ +L G +QK KH
Sbjct: 1798 DLQLRLD--EAEQLAL----KGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHER 1851
Query: 644 KLKDENSQ----------LKSEVSKLRCQLAKKKQSETKLQEELN 678
++K+ Q L+ V KL+ ++ K+ + +E+ N
Sbjct: 1852 RVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSN 1896
Score = 105 bits (263), Expect = 1e-22
Identities = 139/665 (20%), Positives = 285/665 (42%), Gaps = 62/665 (9%)
Query: 68 KVKSSESKKESQKNDKDLKILEKEI----RVLLQERGAQDRRIQDLETELEKMEARLNAA 123
K++ KE + +D + + E+ R L E + I DLE L K+E +A
Sbjct: 918 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 977
Query: 124 LREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMR 183
+ +L+ A L++ + +LT+ + L + +Q+ L L E K+ + K++
Sbjct: 978 ENKVKNLTEEMAGLDETIAKLTKEKKAL-----QEAHQQTLDDLQAEEDKVNTLTKAKIK 1032
Query: 184 ---------GMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL 234
G + +++ + M L+ +R L E K+AQ + EK+++DEK + ++
Sbjct: 1033 LEQQVDDLEGSLEQEKKLRMDLERAKRKL-EGDLKLAQESIMDIENEKQQLDEKLKKKEF 1091
Query: 235 LEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLE---ENIVILSKQVEDLN 291
EIS ++E + QL++ +KE I L++ +E + KQ DL+
Sbjct: 1092 -----EISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1146
Query: 292 VKCQLLEKEKED---HVNRNREHNENLNAEMQNLKQKF------------ILEQQEREKL 336
+ + + + E+ + E N+ AE Q +++ L ++ + +
Sbjct: 1147 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSV 1206
Query: 337 QQKELQIDSL------LQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQ 390
+ QID+L L++EK L S E + K K E+ + D+L +L+
Sbjct: 1207 AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELK 1266
Query: 391 QKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA---ELEKSSAAHTQATLLLQEKYD 447
KEE+ +RL+ L + E +L KEA +L + A TQ L+ + +
Sbjct: 1267 SKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLE 1326
Query: 448 SMVQSLEDVTAQFESYK---ALTASEIEDLKLENSSLQEKAAKAGKNAED--VQHQILAT 502
+++ + +S + L + E+ + + LQ +KA +++ A
Sbjct: 1327 EEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAI 1386
Query: 503 ESSNQ-EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEG 561
+ + + E + L + ++A + E + L+K + +L+ + ED +E
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEK---TKQRLQNEVEDLMLDVERTNA 1443
Query: 562 RKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNK 621
A + + + +W+ EE + + + Q + + E + N + + +QL
Sbjct: 1444 ACAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET 1503
Query: 622 IRDSYAKLLGH-QNLKQKIKHVVKLKDENSQLKSEVSKLRCQL-AKKKQSETKLQEELNK 679
++ L +L ++I K E ++K +V + +C+L A +++E L+ E K
Sbjct: 1504 LKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGK 1563
Query: 680 VLGIK 684
+L I+
Sbjct: 1564 ILRIQ 1568
Score = 104 bits (259), Expect = 3e-22
Identities = 140/696 (20%), Positives = 295/696 (42%), Gaps = 91/696 (13%)
Query: 45 KQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDR 104
+Q+K+ + +L K L + + S E++K D K+ +KE + + +D
Sbjct: 1045 EQEKKLRMDLERAK-RKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDE 1103
Query: 105 RIQ--DLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 162
+ L+ ++++++AR+ E + A+ A EKQ +L+R E + + E G
Sbjct: 1104 QALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGAT 1163
Query: 163 NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG--------KIAQLE 214
+ +I ++ KRE + + M E ++ + T +L + +I L+
Sbjct: 1164 SAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQ 1217
Query: 215 GKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQ 274
+EKEK + K E + L +E +S A +EK + D++ LK
Sbjct: 1218 RVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKM----------CRTLEDQLSELKS 1267
Query: 275 SLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQERE 334
EE + + DL + L+ E + +R + E L +++ KQ F + +E +
Sbjct: 1268 KEEEQ----QRLINDLTAQRGRLQTESGEF-SRQLDEKEALVSQLSRGKQAFTQQIEELK 1322
Query: 335 KLQQKELQIDSLL------------------QQEKELSSSLHQKLCSFQEEMVKEKNLFE 376
+ ++E++ + L ++E+E + L + L E+ + + +E
Sbjct: 1323 RQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYE 1382
Query: 377 EELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHT 436
+ Q +EL++ ++K Q + ++ E ++ L+ +++L+ + +L
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTN 1442
Query: 437 QATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 496
A L +K ++ + + A+++ T +E+E + E SL + K E+
Sbjct: 1443 AACAALDKKQ----RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESL 1498
Query: 497 HQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQL 556
Q+ + N+ + + DL + A I E+ +++ + +L+ E+ L
Sbjct: 1499 DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELE-KIKKQVEQEKCELQAALEEAEASL 1557
Query: 557 EDEEGR-----------KAEKENTTAELTEEINKWR------------LLYEELYNKTKP 593
E EEG+ K+E + AE EEI++ + L E+ ++
Sbjct: 1558 EHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDA 1617
Query: 594 FQLQL----DAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDE 648
+L+ D E+E Q L + + A E L R++ L Q +L ++ LK++
Sbjct: 1618 IRLKKKMEGDLNEMEIQ-LNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQ 1676
Query: 649 NSQ-------LKSEVSKLRCQLAKKKQSETKLQEEL 677
+ L++E+ +LR L + ++S ++EL
Sbjct: 1677 LAMVERRANLLQAEIEELRATLEQTERSRKIAEQEL 1712
Score = 72.8 bits (177), Expect = 1e-12
Identities = 93/435 (21%), Positives = 189/435 (43%), Gaps = 54/435 (12%)
Query: 22 GAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTL--PASARKVKSSESKKESQ 79
G + LE +K V +K + +E++ +L ++ L +VKS +K ++
Sbjct: 1525 GGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE 1584
Query: 80 KNDKDLKILEKEIRVLLQERGAQDRRIQD----------LETELEKMEARLNAALREKTS 129
K+++ ++ IR++ + D I+ +E +L +ME +LN A R
Sbjct: 1585 KDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAE 1644
Query: 130 LSANNATLEK-------QLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE-TK 181
N + L + R+ E LK + + + NL L E+ +LR E T+
Sbjct: 1645 ALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMVERRANL--LQAEIEELRATLEQTE 1702
Query: 182 MRGMMAKQEGMEMKLQV------------TQRSLEESQGKIAQLEGKLVSIEKEKIDEKS 229
+A+QE ++ +V T++ LE I+Q++G++ I +E ++
Sbjct: 1703 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD---ISQMQGEMEDILQEA---RN 1756
Query: 230 ETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVIL----SK 285
EK + I + + +++++K + A LE K + L+ L+E + K
Sbjct: 1757 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKK 1816
Query: 286 QVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDS 345
Q++ L + + LE E E RN E + L + +K+ +++R+ + + + +D
Sbjct: 1817 QIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDK 1876
Query: 346 LLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEE 405
L + K EE ++ N + ++ EL++ +++ + AE V +L
Sbjct: 1877 LQAKVKSYKRQ--------AEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKL-- 1926
Query: 406 EAKSRAEELKLLEEK 420
KSR K++ E+
Sbjct: 1927 RVKSREVHTKVISEE 1941
Score = 70.5 bits (171), Expect = 5e-12
Identities = 95/441 (21%), Positives = 197/441 (44%), Gaps = 70/441 (15%)
Query: 68 KVKSS--ESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLET---ELEKMEARLNA 122
K+K++ ES + + ++ K L++EI L ++ +RI +LE ++E+ + L A
Sbjct: 1489 KIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQA 1548
Query: 123 ALRE-KTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ----KNLRILSLELMKLRNK 177
AL E + SL + + +EL + + K +E + K I +E M+
Sbjct: 1549 ALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD 1608
Query: 178 RETKMRG----MMAKQEG--MEMKLQV-----------------------TQRSLEESQG 208
E + R + K EG EM++Q+ TQ L+++
Sbjct: 1609 AEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALR 1668
Query: 209 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
L+ +L +E+ ++E E+L +E+ + E+ LD ++ + L +N
Sbjct: 1669 SQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTS 1728
Query: 269 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE----------DHVNRNREHNENLNAE 318
+++ K+ LE +I + ++ED+ + + E++ + + + + ++ + +L
Sbjct: 1729 LINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1788
Query: 319 MQNLKQ-----KFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQ---------KLCSF 364
+N++Q + L++ E+ L+ + QI L + +EL + K
Sbjct: 1789 KKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRK 1848
Query: 365 QEEMVKEKNLFEEELKQTL----DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEK 420
E VKE EE ++ + D +DKLQ K + +R ++ EE++ + + + L+ +
Sbjct: 1849 HERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKFRKLQHE 1908
Query: 421 LKGKEAELEKSSAAHTQATLL 441
L +EAE E++ A +Q L
Sbjct: 1909 L--EEAE-ERADIAESQVNKL 1926
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 115 bits (288), Expect = 1e-25
Identities = 145/664 (21%), Positives = 290/664 (43%), Gaps = 95/664 (14%)
Query: 70 KSSESKKESQKNDKDLKILEKEI---RVLLQERGAQDRRIQDLETELEKMEARLNAALR- 125
++ E + E +K+ ++L+K+I ++ ++ A ++ +LE E K++ L++
Sbjct: 626 RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
Query: 126 --EKTSLSANNATLEKQLIELTRTNELLKS----------KFSENGNQKNLRILSLELMK 173
+ SL N+ L+++ +EL R E LK + E ++K LEL+K
Sbjct: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK 745
Query: 174 LRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEK 233
K+ ++ +G++++ Q Q++LE S KI QLE +L +E E +K
Sbjct: 746 ASFKKTERLE---VSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM----ENQTLQK 798
Query: 234 LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVK 293
LE ++ S +Q+EK + Q L++ ++ + L + I +E+ NVK
Sbjct: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
Query: 294 CQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFI----LEQQEREKLQQKELQIDSLLQQ 349
LEKE N+ L+ E+ K+ + LE++ +E +++ + I +L+
Sbjct: 859 IGNLEKE-----------NKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTL 907
Query: 350 EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKS 409
++L S E +K + + +L++ EL+K+ +E + L +E +
Sbjct: 908 REDLVS-----------EKLKTQQM-NNDLEKLTHELEKIGLNKE------RLLHDEQST 949
Query: 410 RAEELKLLEEKLKG---KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKAL 466
KLLE KL+ K E+++ A +A L Y+ ++ +++ ++Y+AL
Sbjct: 950 DDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLR--QELKTVKKNYEAL 1007
Query: 467 TASEIEDLKLENS-SLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKET 525
+ E+ +++S + + K + +++ ++L + E R LQ + +T
Sbjct: 1008 KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKT 1067
Query: 526 EIKEI-----------------TVSFLQKITDLQNQ----------LKQQEEDFRKQLED 558
++K++ TVS ++ T LQ Q L Q Q
Sbjct: 1068 QLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1127
Query: 559 EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 618
+++ EN + +E + LY+ L + +L + E ++L+++HG +
Sbjct: 1128 LLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA 1187
Query: 619 LNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELN 678
+ + L N Q +K +L+D LK E K+ L + K ET + E
Sbjct: 1188 HKNLEVEHRDLEDRYN--QLLKQKGQLEDLEKMLKVEQEKM---LLENKNHET-VAAEYK 1241
Query: 679 KVLG 682
K+ G
Sbjct: 1242 KLCG 1245
Score = 112 bits (280), Expect = 1e-24
Identities = 160/678 (23%), Positives = 299/678 (44%), Gaps = 90/678 (13%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKS---------SESKKESQKNDKDLKILEK 90
K +R +Q+ E K +D L ++K S+++ D+ + EK
Sbjct: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
Query: 91 EIRV--LLQERGAQDRRIQDLE---TELEKMEARLNAALREKTSLS---ANNATLEKQLI 142
+RV L E R+ D+E +E+++ L KT L +L
Sbjct: 319 AVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378
Query: 143 ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQV---- 198
EL + N LK+K + ++++ + K+ E M MA+++ M+ L +
Sbjct: 379 ELEKENLQLKAKLHDMEMERDM-----DRKKIEELMEENMTLEMAQKQSMDESLHLGWEL 433
Query: 199 -----TQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
T E Q + +L S K++ E + L + +EE+ D VE
Sbjct: 434 EQISRTSELSEAPQKSLGHEVNELTSSRLLKLE--MENQSLTKTVEELRTTVDSVEGNAS 491
Query: 254 DIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNE 313
I ++E K ++ LS K + EN ++ KQ CQ L K D + + +
Sbjct: 492 KILKME-----KENQRLSKKVEILENEIVQEKQSLQ---NCQNLSK---DLMKEKAQLEK 540
Query: 314 NLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKN 373
+ +N +++ + +QE E L Q S L+Q ++S+ K ++ KE
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTV----SSLRQRSQISAEARVK------DIEKENK 590
Query: 374 LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSA 433
+ E +K+T +L K++ ++ Q ++ ++ +E+ + RAEEL+ L+ KE EL +
Sbjct: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE-RAEELENELHHLE-KENELLQKKI 648
Query: 434 AHTQATL----LLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAG 489
+ + T L+++ + + + +S+K LT ++E L+ ENS L E+ +
Sbjct: 649 TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEENLELR 707
Query: 490 KNAEDV--------QHQILATE-SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
+N E + Q Q+ E S +E ++ L+L K++ K+TE E++ L D
Sbjct: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL-LKASFKKTERLEVSYQGL----D 762
Query: 541 LQNQ-LKQQEEDFRKQLE--DEEGRKAEKENTTAELT-EEINKWRLLYEELYNKTKPFQL 596
++NQ L++ E+ K+++ + E + E EN T + EE+ E+L + K +
Sbjct: 763 IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
Query: 597 QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEV 656
+ E +K+ L E+ ++Q +I+D+ L N+K + L+ EN L E+
Sbjct: 823 ETSQLEKDKKQLEKENKRLRQQA-EIKDT---TLEENNVK-----IGNLEKENKTLSKEI 873
Query: 657 S--KLRCQLAKKKQSETK 672
K C K+ + E K
Sbjct: 874 GIYKESCVRLKELEKENK 891
Score = 79.0 bits (193), Expect = 1e-14
Identities = 138/595 (23%), Positives = 263/595 (44%), Gaps = 94/595 (15%)
Query: 27 KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESK----------- 75
K+LE + K Q K+ K +Q + KDTTL + K+ + E +
Sbjct: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEI-KDTTLEENNVKIGNLEKENKTLSKEIGIY 876
Query: 76 -------KESQKNDKDL----KILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAAL 124
KE +K +K+L I K + L ++ ++ + Q + +LEK+ L
Sbjct: 877 KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHEL---- 932
Query: 125 REKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNK-RETKMR 183
EK L+ ++Q + +R +LL+SK E+ +K+L I ++ L + E+
Sbjct: 933 -EKIGLNKERLLHDEQSTDDSR-YKLLESKL-ESTLKKSLEIKEEKIAALEARLEESTNY 989
Query: 184 GMMAKQEGMEMKLQVTQRSLEESQGKIAQ----LEGKLVSIEKEKIDEKSETEKLLEYIE 239
+QE +K + + ++ Q + G+ E+E + E K+ + +
Sbjct: 990 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1049
Query: 240 EI--SCASDQVEK--YKLDIAQLEENLKEKNDEILSLKQ---SLEENIVILSKQVEDLNV 292
E+ + A+ Q EK K + QLE +IL+L++ SL+E L Q L V
Sbjct: 1050 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1109
Query: 293 KCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKE 352
+ L + +N+N + + ++N + I E+++ + L DSL++ ++
Sbjct: 1110 ENSTLNSQSTSLMNQNAQLLIQ-QSSLENENESVIKEREDLKSL------YDSLIKDHEK 1162
Query: 353 LSSSLHQKLCSFQEEMVKE--------KNLFEEELKQTLDELDKLQQKEEQAERLVKQLE 404
L LH++ S E ++ + KNL E E + D ++L +++ Q E L K L+
Sbjct: 1163 L-ELLHERQASEYESLISKHGTLKSAHKNL-EVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1220
Query: 405 EEAKSRAEELKLLEEK-LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESY 463
E +E LLE K + AE +K + + L Y +++ E + ++
Sbjct: 1221 VE-----QEKMLLENKNHETVAAEYKKLCGENDR----LNHTYSQLLKETEVLQTDHKNL 1271
Query: 464 KALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ------------EYVR 511
K+L + + KLE + L+ + +K + + Q I +T+ +NQ E R
Sbjct: 1272 KSL----LNNSKLEQTRLEAEFSKLKEQYQ--QLDITSTKLNNQCELLSQLKGNLEEENR 1325
Query: 512 MLLD------LQTKSALKET-EIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
LLD LQ ++ L++ E K++ ++ D N+L++Q+E +++ D+
Sbjct: 1326 HLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
Score = 77.0 bits (188), Expect = 6e-14
Identities = 137/628 (21%), Positives = 264/628 (42%), Gaps = 124/628 (19%)
Query: 139 KQLIELTRTNELL--KSKFSENGNQKNLRILSLEL---MKLRNKRE--TKMRGM-MAKQE 190
+QLI ++ N L+ K+ FSE G ++ ++L L L ++ + K E +++G+ +
Sbjct: 95 QQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKA 154
Query: 191 GMEMKLQVTQRSLEE------------SQGKIAQLEGKLVSIEKEKIDEKSE-TEKLLEY 237
+ +Q + E SQ I L + K IDE+ E +E ++E
Sbjct: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214
Query: 238 IEEIS---------------CASDQVEKY-------------KLDIAQLEENLKEKNDEI 269
EE C S +++ K I +L + L+EK +++
Sbjct: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQL 274
Query: 270 LSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 329
L KQ LE + E + R ++ N NL ++ ++ + +
Sbjct: 275 LDCKQELE----------------------QMEIELKRLQQENMNLLSDARSAR----MY 308
Query: 330 QQEREKLQQKELQIDSLLQQEKELSSSLH---------QKLCSFQEEMVKEKNLFEEELK 380
+ E + L++K +++D L + LH ++L + +++ K + E++L+
Sbjct: 309 RDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLE 368
Query: 381 QTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL 440
T DKL + E++ +L +L + R + K +EE L + LE + +L
Sbjct: 369 GTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE-LMEENMTLEMAQKQSMDESL 427
Query: 441 LLQEKYDSMVQSLEDVTAQFES----YKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQ 496
L + + + ++ E A +S LT+S + L++EN SL + + + V+
Sbjct: 428 HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVE 487
Query: 497 ---HQILATESSNQ-----------EYVRMLLDLQ-----TKSALKETEIKEITVSFLQK 537
+IL E NQ E V+ LQ +K +KE E T+ L++
Sbjct: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE 547
Query: 538 ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQ 597
++ Q ++ +QE + Q R+ + + A + + + ++L+E + K +
Sbjct: 548 NSERQIKILEQENEHLNQTVSSL-RQRSQISAEARVKDIEKENKILHESI----KETSSK 602
Query: 598 LDAFEVEKQAL------LNEHGAAQEQL-NKIR--DSYAKLLGHQ--NLKQKIKHVVKLK 646
L E EK+ + E G E+L N++ + +LL + NLK + + L+
Sbjct: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALE 662
Query: 647 DENSQLKSEVSKLRCQLAKKKQSETKLQ 674
ENS+L+ E KL+ L K +L+
Sbjct: 663 QENSELERENRKLKKTLDSFKNLTFQLE 690
Score = 69.3 bits (168), Expect = 1e-11
Identities = 117/507 (23%), Positives = 217/507 (42%), Gaps = 75/507 (14%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKK---ESQKNDKDL-KILEKEIRV 94
Q Q K K++ + L +D + S E K ESQ+ ++L K+ ++ I V
Sbjct: 992 QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEV 1051
Query: 95 ------LLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
L E+ A +++ LET+ ++A++ A R+ SL N TL+ Q +L N
Sbjct: 1052 ERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN 1111
Query: 149 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
L S+ + NQ N ++L ++ L N+ E+ ++ L+ SL +
Sbjct: 1112 STLNSQSTSLMNQ-NAQLL-IQQSSLENENESVIK--------EREDLKSLYDSLIKDHE 1161
Query: 209 KIAQLEGKLVSIEKEKIDE----KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKE 264
K+ L + S + I + KS + L ++ +Q+ K K + LE+ LK
Sbjct: 1162 KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKV 1221
Query: 265 KNDEILSLKQSLEENIVILSKQV----EDLNVKCQLLEKEKE----DH------VNRNRE 310
+ +++L L+ E + K++ + LN L KE E DH +N ++
Sbjct: 1222 EQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1280
Query: 311 HNENLNAEMQNLKQKFILEQQEREKL-QQKEL--QIDSLLQQEKELSSSLHQKLC----S 363
L AE LK+++ KL Q EL Q+ L++E Q L +
Sbjct: 1281 EQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRT 1340
Query: 364 FQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG 423
E+ ++ K+LF E +Q +D+L++L++++E+ LEEK+
Sbjct: 1341 LLEQNMESKDLFHVEQRQYIDKLNELRRQKEK---------------------LEEKIMD 1379
Query: 424 KEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIED----LKLENS 479
+ + S + L K +++S +D+ + + LT + + L+L +
Sbjct: 1380 QYKFYDPSPPRRRGNWITL--KMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQ 1437
Query: 480 SLQEKAAKAGKNAEDVQHQILATESSN 506
Q+ ++ + ED Q L T+ S+
Sbjct: 1438 DSQDSSSVGSNSLED--GQTLGTKKSS 1462
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 114 bits (286), Expect = 2e-25
Identities = 142/604 (23%), Positives = 263/604 (43%), Gaps = 77/604 (12%)
Query: 47 QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDR-- 104
+ E ++ +K+T L A +K + E+ E Q + +D++ ++EI+ L E Q
Sbjct: 649 EAEKRREALWEKNTHLEAQLQKAE--EAGAELQADLRDIQEEKEEIQKKLSESRHQQEAA 706
Query: 105 --RIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQK 162
+++ L E ++ E L A++EK +L A LE +L + R + L + + K
Sbjct: 707 TTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAK 766
Query: 163 NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEK 222
L SL + +N +G + E+++Q ++ E QG++ L+ +L +
Sbjct: 767 ELLESSLFEAQQQNSVIEVTKGQL------EVQIQTVTQAKEVIQGEVRCLKLELDT--- 817
Query: 223 EKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVI 282
E+S+ E +E A+ Q +AQ E+ K +LE+
Sbjct: 818 ----ERSQAE------QERDAAARQ-------LAQAEQEGKT----------ALEQQKAA 850
Query: 283 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQ 342
K+V L K EKE+ H + E+L E L+ + +Q E E +Q
Sbjct: 851 HEKEVNQLREKW---EKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQA---- 903
Query: 343 IDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 402
Q +E + LC Q E KE+ E L QT EL Q Q ERL +
Sbjct: 904 ------QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQ---QLERLRQD 954
Query: 403 LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFES 462
++ + E +L+ +L+ + EL++++ H LQE+ S++Q D+ Q E
Sbjct: 955 MKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVED 1014
Query: 463 YKALTASEIEDLKLENSSLQEKAAKA---GKNAEDVQHQILATESSNQEYVRMLLDLQTK 519
K+ ++ + +L +QEK + + ++++ + + S E + LL LQ
Sbjct: 1015 LKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEA 1074
Query: 520 SALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINK 579
++++ E+ + +Q+ Q +L Q E R++++++E +E A+L EE+
Sbjct: 1075 DSIRQQELSALRQD-MQEAQGEQKELSAQMELLRQEVKEKEADFLAQE---AQLLEELEA 1130
Query: 580 WRLLYEEL-------YNKTKPFQLQLDAFEVEKQALLNE-----HGAAQEQLNKIRDSYA 627
+ ++L K QL+L + E + +AL E AQ QL + +
Sbjct: 1131 SHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQ 1190
Query: 628 KLLG 631
+ LG
Sbjct: 1191 QALG 1194
Score = 109 bits (273), Expect = 8e-24
Identities = 160/730 (21%), Positives = 313/730 (42%), Gaps = 89/730 (12%)
Query: 29 LEVLKGPVSFQKSQRFKQQKE--------SKQNLNVDKDTTLPASARKVKS--SESKKES 78
+E L+G + + QR Q+ K+N VD K +S
Sbjct: 1437 VETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAV 1496
Query: 79 QKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLE 138
Q+ ++ L + ++IR L ++R Q ++ ELEK + + + + L TLE
Sbjct: 1497 QEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLE 1556
Query: 139 KQLIELTRTNELLKSKFSE----NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEM 194
+EL + ++ + G ++ R+ L +R +++ ++ +E
Sbjct: 1557 CLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLES 1616
Query: 195 KLQVTQRSLEESQGKIAQLEGKLVSIEKEKI----DEKSETEKLLEYIEEISCASDQVEK 250
V R L+E ++ ++ ++++K D + ++L+ E I DQ +
Sbjct: 1617 HSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTR 1676
Query: 251 Y----KLDIAQLEENLKEKNDEILSLKQSLEENIV-----ILSKQVEDLNVKCQLLEKEK 301
+ D+ Q++ +L+E+ E+ + +Q ++E +++ ++K L +KEK
Sbjct: 1677 QTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEK 1736
Query: 302 E-----DHVNRNREHNENLNAEMQNLKQKF---------------ILEQQEREKLQQKEL 341
E +H++ +E + L ++Q L +K +L+QQ +E +Q EL
Sbjct: 1737 EVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGEL 1796
Query: 342 QIDSLLQQEKELSSSL------------HQKLCSFQEEMVKEK-NLFEEELKQ---TLDE 385
+ SL Q E +L Q+ QEE VKEK + + L+Q TL E
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 386 LD-KLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQE 444
+LQ +EQA RL ++L E + R + L+ + L+ + E EK+ A Q +
Sbjct: 1857 RHGELQDHKEQARRLEEELAVEGR-RVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915
Query: 445 KYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATES 504
+++ ++L+D Q ++ E+E L+ E+ S + + A AE +Q + +
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHA 1975
Query: 505 SNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ---LEDEEG 561
+ Q + LL+ A ++ T + + Q +Q EE R Q ++D++
Sbjct: 1976 ALQGKEQHLLE----QAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL 2031
Query: 562 RKAEK----ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
R E + A+ EE+ + + E+L K+ ++Q + + EKQ L E +E
Sbjct: 2032 RYQEDVQQLQQALAQRDEEL-RHQQEREQLLEKSLAQRVQENMIQ-EKQNLGQER--EEE 2087
Query: 618 QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSE-------VSKLRCQLAKKKQSE 670
++ + S +L L QK + +++L++ + E S + Q K E
Sbjct: 2088 EIRGLHQSVREL--QLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLE 2145
Query: 671 TKLQEELNKV 680
+LQ EL ++
Sbjct: 2146 PRLQRELERL 2155
Score = 99.4 bits (246), Expect = 1e-20
Identities = 131/639 (20%), Positives = 281/639 (43%), Gaps = 57/639 (8%)
Query: 60 TTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEAR 119
T L A A + ++ K + +L +++ L + + + TEL+ ++ +
Sbjct: 1234 TALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQ 1293
Query: 120 LNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRE 179
L+ EK+ +LE +L+EL T L+S+ LR L+ M+ + +RE
Sbjct: 1294 LSQNQEEKSKWEGKQNSLESELMELHETMASLQSR---------LRRAELQRMEAQGERE 1344
Query: 180 TKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQ---LEGKL------VSIEKEKIDEKSE 230
+ A +E + +++ Q ++ E++ + + LE L + ++ E+++ + E
Sbjct: 1345 L----LQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERE 1400
Query: 231 TEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL 290
+ L+ E+ A Q + + ++A L + L E+ +E+ +L+ ++E L KQ E
Sbjct: 1401 RAQALQEQGELKVA--QGKALQENLALLTQTLAEREEEVETLRGQIQE----LEKQREMQ 1454
Query: 291 NVKCQLLE---KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL 347
+LL K++ V+ +E + L L+ + Q+ +KL + QI L
Sbjct: 1455 KAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELE 1514
Query: 348 QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEA 407
+ + + L +L E+ K+ + E + Q D L+++ E L +LEE
Sbjct: 1515 KDRETQRNVLEHQLL----ELEKKDQMIESQRGQVQD----LKKQLVTLECLALELEENH 1566
Query: 408 KSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALT 467
+ KL++E E + E A T TL L+E+ + Q+ ES+ +
Sbjct: 1567 HKMECQQKLIKE----LEGQRETQRVALTHLTLDLEERSQEL-QAQSSQIHDLESHSTVL 1621
Query: 468 ASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESS---NQEYVRMLLDLQTK-SALK 523
A E+++ E S +E+ + + E + + + +E +++L D +T+ + +
Sbjct: 1622 ARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKIL 1681
Query: 524 ETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLL 583
E ++++I +S ++ +L Q + +E + + ++ E+ L ++ +
Sbjct: 1682 EEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQ 1741
Query: 584 YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVV 643
E ++ Q D E + Q L + G L++ L Q Q+ +
Sbjct: 1742 QEHIHE----LQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVL---QQQLQEAREQG 1794
Query: 644 KLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG 682
+LK+++ L+S++ + + LA++ Q LQ+E + G
Sbjct: 1795 ELKEQS--LQSQLDEAQRALAQRDQELEALQQEQQQAQG 1831
Score = 98.6 bits (244), Expect = 2e-20
Identities = 145/694 (20%), Positives = 303/694 (43%), Gaps = 100/694 (14%)
Query: 33 KGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEI 92
+G Q+ Q+ ++++ VD + + +++ + + +E + + L++LE+E
Sbjct: 429 EGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELR--QQLEVLEQEA 486
Query: 93 RVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLE----KQLIELTRTN 148
L + + + + E+ + L+ A+RE+ L LE + L EL
Sbjct: 487 WRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLR 546
Query: 149 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
E L+S E +L + +T++ +A+ E +L ++ +L+
Sbjct: 547 EALESSHLEG--------------ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 209 KIAQLEGKLVSI-EKEKIDEKSETEKLLEYIEEISCASDQVEK-------YKLDIAQLE- 259
+ KL ++ E +D+ ++LL+ EE ++E ++D+A+ E
Sbjct: 593 DLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEK 652
Query: 260 --ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNA 317
E L EKN + + Q EE L + D+ + + ++K+ ++ +R E
Sbjct: 653 RREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKK----LSESRHQQEAATT 708
Query: 318 EMQNLKQKFILEQ-------QEREKLQQKELQIDSLLQQEKELSSSLHQKL--CSFQEEM 368
+++ L Q+ ++ QE+E L +++ ++ LQ + L ++L S +E+
Sbjct: 709 QLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL 768
Query: 369 VKEKNLFEEELKQTLDELDKLQ-----QKEEQAERLVK---------------QLEEEAK 408
+ E +LFE + + ++ E+ K Q Q QA+ +++ Q E+E
Sbjct: 769 L-ESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERD 827
Query: 409 SRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTA 468
+ A +L E++ GK A LE+ AAH + L+EK++ E Q E KAL +
Sbjct: 828 AAARQLAQAEQE--GKTA-LEQQKAAHEKEVNQLREKWEK-----ERSWHQQELAKALES 879
Query: 469 SEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSAL--KETE 526
E E ++LE ++ Q ++ A ++ +E Q +SAL + E
Sbjct: 880 LEREKMELE------------MRLKEQQTEMEAIQAQREEE-----RTQAESALCQMQLE 922
Query: 527 IKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEE 586
++ VS L+ + Q +L + + +D + +K +++ TT L ++ + + E
Sbjct: 923 TEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ---RE 979
Query: 587 LYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY-----AKLLGHQNLKQKIKH 641
L + + L A + E +LL + Q+Q+ ++ ++ L Q +++K++
Sbjct: 980 LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRE 1039
Query: 642 VVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
+ +L+ E + L L +K+Q LQE
Sbjct: 1040 TQEYNRIQKELEREKASLTLSLMEKEQRLLVLQE 1073
Score = 90.9 bits (224), Expect = 4e-18
Identities = 137/711 (19%), Positives = 306/711 (43%), Gaps = 71/711 (9%)
Query: 27 KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLK 86
+T+ L+ + + QR + Q E ++ L K+ L A ++++ + +Q +
Sbjct: 1320 ETMASLQSRLRRAELQRMEAQGE-RELLQAAKEN-LTAQVEHLQAAVVEARAQASAAG-- 1375
Query: 87 ILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAA---LREKTSLSANNATLEKQLIE 143
ILE+++R R A + +++E+E E+ +A + + +L N A L + L E
Sbjct: 1376 ILEEDLRTA---RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE 1432
Query: 144 LTRTNELLKSKFSENGNQKNLRILSLELMKL----RNKRETKMRGMMAKQEGMEMKLQVT 199
E L+ + E Q+ ++ +LEL+ L RN+ + + + E L+
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492
Query: 200 QRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEE----ISCASDQVEKYKLDI 255
+++E + K+ ++ +EK++ +++ E L +E+ I QV+ K +
Sbjct: 1493 PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552
Query: 256 A-------QLEEN---LKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHV 305
+LEEN ++ + I L+ E V L+ DL + Q L+ + +
Sbjct: 1553 VTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ-I 1611
Query: 306 NRNREHNENLNAEMQNLKQKFILEQQEREKLQ-QKELQIDSLLQQEKELSSSLHQKLCSF 364
+ H+ L E+Q Q+ ++++ E+LQ QKE L ++++EL +++
Sbjct: 1612 HDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQ-KERIQVL 1670
Query: 365 QEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGK 424
+++ ++ + EE+L+Q L + ++ +L+++ EE K ++ + E +K
Sbjct: 1671 EDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLI 1730
Query: 425 EAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEK 484
+ EK + LQE D + Q L+ + + L + +++ + LQE
Sbjct: 1731 LRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEA 1790
Query: 485 AAKAGKNAEDVQHQILATE---SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDL 541
+ + +Q Q+ + + + + L Q ++ +E +KE + +
Sbjct: 1791 REQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQA 1850
Query: 542 QNQLK------QQEEDFRKQLEDE---EGRKAEK-----ENTTAELTEEINKWRLLYEEL 587
LK Q ++ ++LE+E EGR+ + + AE E+ L ++
Sbjct: 1851 HMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQC 1910
Query: 588 YNKTKPFQL---------------------QLDAFEVEKQALLNEHGAAQEQLNKIRDSY 626
+ + ++ +L+A E Q+ ++ AA+ + ++++
Sbjct: 1911 AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEAL 1970
Query: 627 AKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 677
K H L+ K +H+++ + + L++ + L+ L + +L+E L
Sbjct: 1971 GK--AHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEAL 2019
Score = 82.0 bits (201), Expect = 2e-15
Identities = 138/719 (19%), Positives = 299/719 (41%), Gaps = 66/719 (9%)
Query: 13 DPSGCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQK--ESKQNLNVDK----DTTLPASA 66
+P+G G + L +L +K + Q+ + K +++K D SA
Sbjct: 231 EPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSA 290
Query: 67 RKVKSSESKKESQKNDKDLK----ILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNA 122
+S + ++ +K K L+ ILE L++ + R Q+ + L+++ +
Sbjct: 291 LLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQ 350
Query: 123 ALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKM 182
+ E+ A + E L + + S+F K L ++ L + R +
Sbjct: 351 VMVEEGDNIAQGSGHENSL----ELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLR 406
Query: 183 RGMMAKQEGMEMKLQVTQRSLEESQG---KIAQLEGKLVSIEKEKIDEKSETEKLLEYIE 239
+ + QE + + Q + EE + ++ +L G+ ++ + +D + E + L + E
Sbjct: 407 QQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERE 466
Query: 240 EISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEK 299
+ A +++ + + Q L+ N E+ S + +Q E+L++ + E+
Sbjct: 467 LLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQ---KEEQQEELHLAVRERER 523
Query: 300 EKEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLL----QQEKELSS 355
+E + + +E+L+ E+ L++ E E L+Q++ ++ + L Q ELSS
Sbjct: 524 LQEMLMGLEAKQSESLS-ELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSS 582
Query: 356 SLHQ-------------KLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQ 402
S + KL + E + +K ++L Q +E + + E AE+
Sbjct: 583 SENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNA 642
Query: 403 LEEEAKSRAEELKLLEEKLKGKEAELEKS--SAAHTQATLL--------LQEKYDSMVQS 452
L+ + + + L EK EA+L+K+ + A QA L +Q+K
Sbjct: 643 LQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQ 702
Query: 453 LEDVTAQFESYK----------ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILAT 502
E T Q E A E E L E ++L+ + ++ +D+ Q+
Sbjct: 703 QEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGL 762
Query: 503 ESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGR 562
S+ + L + Q ++++ E ++ V +Q +T + ++ + + +L+ E +
Sbjct: 763 SSAKELLESSLFEAQQQNSVIEVTKGQLEVQ-IQTVTQAKEVIQGEVRCLKLELDTERSQ 821
Query: 563 KAEKENTTAE---LTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQL 619
++ + A E+ K L ++ ++ + QL+ + +E E+ E A E L
Sbjct: 822 AEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLR-EKWEKERSWHQQELAKALESL 880
Query: 620 NKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQS--ETKLQEE 676
+ + L Q + + + ++E +Q +S + +++ + K++ S ET LQ +
Sbjct: 881 EREKMELEMRLKEQQTEMEAIQAQR-EEERTQAESALCQMQLETEKERVSLLETLLQTQ 938
Score = 82.0 bits (201), Expect = 2e-15
Identities = 153/762 (20%), Positives = 325/762 (42%), Gaps = 105/762 (13%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQE 98
Q+ +R +Q + Q L + T + + + E K+ ++++ DL L++E LLQ+
Sbjct: 946 QQLERLRQDMKV-QKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQD 1004
Query: 99 RGAQDRRIQDLETEL---------------EKMEA-----RLNAAL-REKTSLSANNATL 137
+ ++++DL+++L EK+ R+ L REK SL+ +
Sbjct: 1005 KMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEK 1064
Query: 138 EKQLIELTRTNELLKSKFS--------ENGNQKNLRILSLELMKLRNKRETKMRGMMAKQ 189
E++L+ L + + + + S G QK LS ++ LR + + K +A++
Sbjct: 1065 EQRLLVLQEADSIRQQELSALRQDMQEAQGEQKE---LSAQMELLRQEVKEKEADFLAQE 1121
Query: 190 EGMEMKLQ---VTQRSLEES----QGKIAQLEGKLVSIEK--EKIDEKSETEKLLEYIEE 240
+ +L+ +T++ L S + K AQL+ +L S E E + + + + +
Sbjct: 1122 AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ 1181
Query: 241 ISCASDQVEKYKLDIAQLEENLKEKNDEILSL---------------------KQSLEEN 279
++ +++ + + L D S+ S E
Sbjct: 1182 LASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAV 1241
Query: 280 IVILSKQVEDLNVKCQLLE------KEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
L K +DL Q + ++ E+ + ++ E+Q+L+++ Q+E+
Sbjct: 1242 ASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEK 1301
Query: 334 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK---EKNLFEEELKQTLDELDKLQ 390
K + K+ ++S L + E +SL +L + + ++ E+ L + + +++ LQ
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ 1361
Query: 391 QKEEQAERLVKQ---LEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATL------L 441
+A LEE+ ++ LKL E++ E+E E++ A Q L
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEV---ESERERAQALQEQGELKVAQGKA 1418
Query: 442 LQEKYDSMVQSLEDVTAQFESYKALTAS-----EIEDLKLENSSLQEKAAKAGKNAEDVQ 496
LQE + Q+L + + E+ + E++ LE SL K + + Q
Sbjct: 1419 LQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQ 1478
Query: 497 HQILATESSNQEYVRMLL-DLQTKSALKETEIKEITVSFLQKITDLQNQLKQQE------ 549
Q L S E++ M + + + K ++ +I+E+ + L++QL + E
Sbjct: 1479 IQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI 1538
Query: 550 EDFRKQLEDEEGRKAEKENTTAELTEEINKW---RLLYEELYNKTKPFQLQLDAFEVEKQ 606
E R Q++D + + E EL E +K + L +EL + + ++ L ++ +
Sbjct: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLE 1598
Query: 607 ALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKK 666
E A Q++ + +S++ +L + L+++ + V +++ +L+ + L L ++
Sbjct: 1599 ERSQELQAQSSQIHDL-ESHSTVLARE-LQERDQEVKSQREQIEELQRQKEHLTQDLERR 1656
Query: 667 KQSETKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
Q E LQ+E +VL + +K + ++ +K L+E
Sbjct: 1657 DQ-ELMLQKERIQVLEDQRTRQTKILEEDLEQ---IKLSLRE 1694
Score = 63.2 bits (152), Expect = 8e-10
Identities = 117/567 (20%), Positives = 240/567 (42%), Gaps = 85/567 (14%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKD-LKILEKEIRVLLQE 98
K Q + Q + Q +D L A ++ + ++ ++E K D L+ ++ + L+E
Sbjct: 1797 KEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE 1856
Query: 99 RGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
R + +QD + + ++E L R +L L + E + L+ + +E
Sbjct: 1857 RHGE---LQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQ 1913
Query: 159 GNQKNLRILSLE--------LMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKI 210
+ + +L+ ++K R++ +R E + +L+E+ GK
Sbjct: 1914 AQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKA 1973
Query: 211 -AQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEI 269
A L+GK ++ + E++E + LE AS + LD Q
Sbjct: 1974 HAALQGK-----EQHLLEQAELSRSLE-------ASTATLQASLDACQAHS--------- 2012
Query: 270 LSLKQSLEENIVILSKQVEDLNVK----CQLLEK---EKEDHVNRNREHNENLNAEMQNL 322
+ LEE + I +++D +++ Q L++ ++++ + +E + L +
Sbjct: 2013 ----RQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQR 2068
Query: 323 KQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQE-EMVKEKNLFE----- 376
Q+ ++++++ +++E +I L Q +EL +L QK E +++N E
Sbjct: 2069 VQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHS 2128
Query: 377 ------EELKQTLDELD-KLQQKEEQAERLVKQLEE---EAKSRAEELKLLEEKLKGKEA 426
EE LD L+ +LQ++ E+ + ++Q E E + +A++L L + K +
Sbjct: 2129 HKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVS 2188
Query: 427 ELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAA 486
L++ A QA++L + DS Q L+D LT +E +L + A
Sbjct: 2189 SLQE-VAMFLQASVL---ERDSEQQRLQDEL-------ELTRRALEKERLHSPGATSTAE 2237
Query: 487 KAGKNAEDVQ-HQILATES-------SNQEYVRMLLDLQTKSALKETEIKEITVSFLQKI 538
+ + VQ ++ E+ Q + + L LQ A E + + +Q
Sbjct: 2238 LGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQ-- 2295
Query: 539 TDLQNQLKQQEEDFRKQLEDEEGRKAE 565
L++ L+Q E + R++L+ E R A+
Sbjct: 2296 --LRSTLEQVERE-RRKLKREAMRAAQ 2319
Score = 41.6 bits (96), Expect = 0.003
Identities = 66/335 (19%), Positives = 140/335 (41%), Gaps = 43/335 (12%)
Query: 39 QKSQRFKQQKESKQNLNVD------KDTTLPASARKVKSSESKKESQKNDKDLKILEKEI 92
QK Q + +E++Q N++ K + + + K+ S E + + + + + E
Sbjct: 2105 QKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQAALRQTEA 2164
Query: 93 RVLLQERGAQDRRIQDLETE-----LEKMEARLNAALREKTSLSANNATLEKQLIELTRT 147
R + AQD + +T+ L+++ L A++ E+ S L+ +L ELTR
Sbjct: 2165 REIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDS---EQQRLQDEL-ELTR- 2219
Query: 148 NELLKSKFSENGNQKNLRILSLELMKLRNKRETKM---RGMMAKQEGMEMKLQVTQRSLE 204
L K + G + S R ++ ++ G+ A+ M+ Q ++ LE
Sbjct: 2220 RALEKERLHSPGATSTAELGS------RGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLE 2273
Query: 205 ESQGKIAQLEGKLVSIEKEKIDEKSETEKL--------LEYIEEISCASDQVEKYKLDIA 256
Q +A+LE +++ + +S E++ E + S ++ K
Sbjct: 2274 HLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSP 2333
Query: 257 QLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLN 316
++ +KN + + + L++ +V+L Q+ L K+K+D++ R+ + + L
Sbjct: 2334 TQQDGRGQKNSDAKCVAE-LQKEVVLLQAQLT-------LERKQKQDYITRSAQTSRELA 2385
Query: 317 AEMQNLKQKFILEQQ--EREKLQQKELQIDSLLQQ 349
+L + Q E L+ + ++D L Q
Sbjct: 2386 GLHHSLSHSLLAVAQAPEATVLEAETRRLDESLTQ 2420
>gi|32698688 citron [Homo sapiens]
Length = 2027
Score = 114 bits (286), Expect = 2e-25
Identities = 141/636 (22%), Positives = 275/636 (43%), Gaps = 94/636 (14%)
Query: 70 KSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTS 129
K+S +K+ K+L+ + + + QE RR+ ++E L + E L A+ +++
Sbjct: 443 KTSSMEKKLLIKSKELQDSQDKCHKMEQEMTRLHRRVSEVEAVLSQKEVELKASETQRSL 502
Query: 130 LSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQ 189
L + AT + L R+ E + + S+ ++ +L+L+ ++ K++
Sbjct: 503 LEQDLATYITECSSLKRSLEQARMEVSQEDDK------ALQLLHDIREQSRKLQ------ 550
Query: 190 EGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVE 249
E+K Q Q +EE + + QLE LVS + +SE +
Sbjct: 551 ---EIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESE-----------------LR 590
Query: 250 KYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNR 309
+ +L + + E ++L K + + +K +E +N + QL +E ++ + +
Sbjct: 591 ESRLAAEEFKRKATECQHKLLKAKDQGKPEVGEYAK-LEKINAEQQLKIQELQEKLEKAV 649
Query: 310 EHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMV 369
+ + +QN++Q ++E EKLQ +E + S + +KL +E +
Sbjct: 650 KASTEATELLQNIRQAKERAERELEKLQNRE-----------DSSEGIRKKLVEAEE--L 696
Query: 370 KEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELE 429
+EK+ + Q L+ L+QKE+ E +K L+ + K + + LE ++ E E
Sbjct: 697 EEKHREAQVSAQHLEV--HLKQKEQHYEEKIKVLDNQIKKDLADKETLENMMQRHEEE-- 752
Query: 430 KSSAAHTQATLLLQEK-----YDSMVQSLEDVTAQFESYKALTASE-------------- 470
AH + +L ++K DS ++SLE + L A+
Sbjct: 753 ----AHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEM 808
Query: 471 IEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI 530
I +L+ + L+ +A K ++ Q+ + LL+L+T+ E +E
Sbjct: 809 ISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETRLREVSLEHEEQ 868
Query: 531 TVSFLQKITDLQNQLKQQEEDF------RKQLEDE-EGRKAEKENTTAELTEEINKWRLL 583
+ +++T+LQ L+++E R LE + K E E TTAE EEI
Sbjct: 869 KLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEAEEEIQALTAH 928
Query: 584 YEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN--LKQKIKH 641
+E+ Q + DA + + +EQLN++ + A+ L +QN L +++
Sbjct: 929 RDEI-------QRKFDALRNSCTVITD----LEEQLNQLTEDNAE-LNNQNFYLSKQLDE 976
Query: 642 VVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEEL 677
DE QL+SEV LR ++ +++ T ++ +
Sbjct: 977 ASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTM 1012
Score = 108 bits (271), Expect = 1e-23
Identities = 152/682 (22%), Positives = 289/682 (42%), Gaps = 72/682 (10%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKE--SQKNDKDLKILEKEIRVLL 96
QK K + + L D T + + +S E + SQ++DK L++L +IR
Sbjct: 488 QKEVELKASETQRSLLEQDLATYITECSSLKRSLEQARMEVSQEDDKALQLLH-DIRE-- 544
Query: 97 QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFS 156
Q R Q+ + Q+ + ++E+M +N + S + E +L E E K K +
Sbjct: 545 QSRKLQEIKEQEYQAQVEEMRLMMNQLEEDLVSARRRSDLYESELRESRLAAEEFKRKAT 604
Query: 157 ENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGK 216
E ++ L+K +++ + ++ G AK E + + Q+ + L+E K + +
Sbjct: 605 ECQHK---------LLKAKDQGKPEV-GEYAKLEKINAEQQLKIQELQEKLEKAVKASTE 654
Query: 217 LVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSL---- 272
+ + K E+ LE ++ +S+ + K ++ +LEE +E L
Sbjct: 655 ATELLQNIRQAKERAERELEKLQNREDSSEGIRKKLVEAEELEEKHREAQVSAQHLEVHL 714
Query: 273 ---KQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILE 329
+Q EE I +L Q +K L +KE + N + H E + + + L ++ +
Sbjct: 715 KQKEQHYEEKIKVLDNQ-----IKKDLADKETLE--NMMQRHEEEAHEKGKILSEQKAMI 767
Query: 330 QQEREKLQQKELQIDSLLQQEK--ELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELD 387
K++ E +I L + K SS Q+ QEEM+ E + L+ +L+
Sbjct: 768 NAMDSKIRSLEQRIVELSEANKLAANSSLFTQRNMKAQEEMISELRQQKFYLETQAGKLE 827
Query: 388 KLQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKY 446
+K EEQ E++ Q +++ +LLE + + +E LE H + L L+ +
Sbjct: 828 AQNRKLEEQLEKISHQ------DHSDKNRLLELETRLREVSLE-----HEEQKLELKRQL 876
Query: 447 DSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSN 506
+ SL++ +Q + +A A+ L+ + L+E A+A + +I A +
Sbjct: 877 TELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAEA-------EEEIQALTAHR 929
Query: 507 QEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEK 566
E R L+ + ITDL+ QL Q ED +L ++ +++
Sbjct: 930 DEIQRKFDALRNSCTV---------------ITDLEEQLNQLTED-NAELNNQNFYLSKQ 973
Query: 567 ENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSY 626
+ + +EI + R + L + ++QL + + +AL +EQ+ +
Sbjct: 974 LDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALN 1033
Query: 627 AKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIKHF 686
+LL + + + V L DE SQ + V +L+ L +KQS + + + + +
Sbjct: 1034 DELLEKERQWEAWRSV--LGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVEL 1091
Query: 687 DPSKAFHHESKENFALKTPLKE 708
A E AL+ LKE
Sbjct: 1092 ----AVKEHKAEILALQQALKE 1109
Score = 70.9 bits (172), Expect = 4e-12
Identities = 113/576 (19%), Positives = 229/576 (39%), Gaps = 113/576 (19%)
Query: 25 DVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKK----ESQK 80
D +TLE + + ++ K E K +N R V+ SE+ K S
Sbjct: 738 DKETLENMMQRHEEEAHEKGKILSEQKAMINAMDSKIRSLEQRIVELSEANKLAANSSLF 797
Query: 81 NDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARL-----------NAALREKTS 129
+++K E+ I L Q++ + + LE + K+E +L N L +T
Sbjct: 798 TQRNMKAQEEMISELRQQKFYLETQAGKLEAQNRKLEEQLEKISHQDHSDKNRLLELETR 857
Query: 130 LSANNATLEKQLIELTRTNELLKSKFSENGNQ------------KNLRILSLELMKLRNK 177
L + E+Q +EL R L+ E +Q LR EL + +
Sbjct: 858 LREVSLEHEEQKLELKRQLTELQLSLQERESQLTALQAARAALESQLRQAKTELEETTAE 917
Query: 178 RETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEY 237
E +++ + A ++ ++ K +L S I LE +L + ++ + ++ L +
Sbjct: 918 AEEEIQALTAHRDEIQRKFD----ALRNSCTVITDLEEQLNQLTEDNAELNNQNFYLSKQ 973
Query: 238 IEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEE---NIVILSKQVEDLNV-- 292
++E S A+D++ + + ++ L + E+ ++ S KQ++E +L +QV DL
Sbjct: 974 LDEASGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVMDLEALN 1033
Query: 293 ------------------------KCQ------LLEKEKEDHVNRN-------------- 308
+C+ +L+ EK+ +
Sbjct: 1034 DELLEKERQWEAWRSVLGDEKSQFECRVRELQRMLDTEKQSRARADQRITESRQVVELAV 1093
Query: 309 REHNENLNAEMQNLKQKFILEQQEREKLQQKELQ----------IDSLLQQEKELSSSLH 358
+EH + A Q LK++ + + +KL E + + L+ E+EL L
Sbjct: 1094 KEHKAEILALQQALKEQKLKAESLSDKLNDLEKKHAMLEMNARSLQQKLETERELKQRLL 1153
Query: 359 QKLCSFQEEMVKEKN---LFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELK 415
++ Q++M +KN + L++ LD D L+ + E ++ + ++
Sbjct: 1154 EEQAKLQQQMDLQKNHIFRLTQGLQEALDRADLLKTERSDLEYQLENI---------QVL 1204
Query: 416 LLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTAS---EIE 472
EK+K +E + + T+ LQ K D + + + ++ + AL +
Sbjct: 1205 YSHEKVK-----MEGTISQQTKLIDFLQAKMDQPAKKKKGLFSRRKEDPALPTQVPLQYN 1259
Query: 473 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQE 508
+LKL +L+++ A+ + E +Q + S+ +E
Sbjct: 1260 ELKL---ALEKEKARCAELEEALQKTRIELRSAREE 1292
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 114 bits (286), Expect = 2e-25
Identities = 132/569 (23%), Positives = 250/569 (43%), Gaps = 64/569 (11%)
Query: 172 MKLRNKRETKMRGMMAKQEGMEMK--LQVTQRSLEESQGKIAQLEGKLVSIEKEKID--- 226
M L K + ++ A++E MK + T+ L S+ + +LE K+VS+ +EK D
Sbjct: 834 MNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQL 893
Query: 227 -EKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEK---NDEILSLKQSLEENIVI 282
+SETE L++ E + + +L E L+E+ N E+++ K++LE+
Sbjct: 894 QVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSS 953
Query: 283 LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNL----KQKFILE---QQEREK 335
L + ++DL + +EKEK N+ + +E + A +N+ K+K L+ QQ +
Sbjct: 954 LKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDD 1013
Query: 336 LQQKELQIDSLL-------QQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
LQ +E +++ L+ QQ +L SL Q+ + ++ + K E +LK + + +
Sbjct: 1014 LQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEK-KLRADLERAKRKLEGDLKMSQESIMD 1072
Query: 389 LQQKEEQAERLVKQLEEE-----AKSRAEELKLLEEKLKGKE-----AELEKSSAAHTQA 438
L+ ++Q E +K+ E E AK E++ L+ + K KE ELE+ A
Sbjct: 1073 LENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTL 1132
Query: 439 TLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLK------------LENSSLQEKAA 486
++++ + + LE+++ + E T+++IE K LE ++LQ +A
Sbjct: 1133 RAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEAT 1192
Query: 487 KA---GKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQK------ 537
A K A+ V L + N + V+ L+ + E + + L K
Sbjct: 1193 AATLRKKQADSVAE--LGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIE 1250
Query: 538 -----ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 592
+ D +++K ++E + + D +KA + EL+ + + L +L +
Sbjct: 1251 RTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQ 1310
Query: 593 PFQLQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL 652
QL+ + + + A L R L +Q+ K +L+ S+
Sbjct: 1311 ALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAK--AELQRALSKA 1368
Query: 653 KSEVSKLRCQLAKKKQSETKLQEELNKVL 681
SEV++ R + T+ EE K L
Sbjct: 1369 NSEVAQWRTKYETDAIQRTEELEEAKKKL 1397
Score = 112 bits (280), Expect = 1e-24
Identities = 140/684 (20%), Positives = 297/684 (43%), Gaps = 82/684 (11%)
Query: 42 QRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGA 101
+R K++ E ++ + L ++++ KKE + + KI ++++ L ++
Sbjct: 1053 ERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQK-- 1110
Query: 102 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQ 161
+I++L+ +E++E + A E T A +EKQ +L R E + + E
Sbjct: 1111 ---KIKELQARIEELEEEIEA---EHTL----RAKIEKQRSDLARELEEISERLEEASGA 1160
Query: 162 KNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG--------KIAQL 213
+ +I ++ KRE + + M E ++ + T +L + Q +I L
Sbjct: 1161 TSAQI------EMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNL 1214
Query: 214 EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
+ +EKEK + K E + + IE +S + +E+ + +K K+++ L
Sbjct: 1215 QRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLI 1274
Query: 274 QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
L L Q +L+ + + EKE +++ + + L +++ LK++ +E++ +
Sbjct: 1275 HDLNMQKARLQTQNGELSHRVE----EKESLISQLTKSKQALTQQLEELKRQ--MEEETK 1328
Query: 334 EK------LQQKELQIDSLLQQ---EKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 384
K LQ D L +Q E+E + L + L E+ + + +E + Q +
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTE 1388
Query: 385 ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKS-SAAHTQATLLLQ 443
EL++ ++K Q + ++ E A S+ L+ +++L+G+ +L + +HT L
Sbjct: 1389 ELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL-- 1446
Query: 444 EKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
D ++ + V A+++ + +E+E + E+ SL + K E+V Q+
Sbjct: 1447 ---DKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLR 1503
Query: 504 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
N+ + DL TE T LQ+ + ++Q++ D + LE+ EG
Sbjct: 1504 RENKNLQEEISDL--------TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSL 1555
Query: 564 AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQLNKIR 623
+E+ + E+++ + EL K ++ E +Q N AA E L +
Sbjct: 1556 EHEESKILRVQLELSQ---VKSELDRKV------IEKDEEIEQLKRNSQRAA-EALQSVL 1605
Query: 624 DSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLG- 682
D+ + +N ++K +++ +++++ QL + + Q+ L V G
Sbjct: 1606 DAEIR---SRNDALRLK---------KKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQ 1653
Query: 683 IK----HFDPSKAFHHESKENFAL 702
+K H D + + + KE A+
Sbjct: 1654 LKDSQLHLDDALRSNEDLKEQLAI 1677
Score = 110 bits (274), Expect = 6e-24
Identities = 144/663 (21%), Positives = 285/663 (42%), Gaps = 70/663 (10%)
Query: 74 SKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSAN 133
+K+E +++ K LE+++ LLQE+ ++Q L E R ++ K L A
Sbjct: 863 TKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAK 922
Query: 134 NATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGME 193
L ++L E N EL+ + E K + + +E
Sbjct: 923 VKELTERLEEEEEMNS--------------------ELVAKKRNLEDKCSSLKRDIDDLE 962
Query: 194 MKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL 253
+ L ++ ++ K+ L ++ ++E E I + ++ +K L+ + + QVE+ K+
Sbjct: 963 LTLTKVEKEKHATENKVKNLSEEMTALE-ENISKLTKEKKSLQEAHQQTLDDLQVEEDKV 1021
Query: 254 D-IAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHN 312
+ + ++ L+++ D+ L+ SLE Q + L + +++ E + ++E
Sbjct: 1022 NGLIKINAKLEQQTDD---LEGSLE--------QEKKLRADLERAKRKLEGDLKMSQESI 1070
Query: 313 ENLNAEMQNLKQKFILEQQEREKLQQK--ELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
+L + Q +++K ++ E +LQ K + Q+ SL Q+K L ++ +EE+
Sbjct: 1071 MDLENDKQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKK--IKELQARIEELEEEIEA 1128
Query: 371 EKNLFEEELKQTLD---ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAE 427
E L + KQ D EL+++ ++ E+A E K R E + + L +EA
Sbjct: 1129 EHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDL--EEAT 1186
Query: 428 LEKSSAAHTQATLLLQEKYDSM------VQSLEDVTAQFESYKALTASEIEDLKLENSSL 481
L+ + A T L +++ DS+ + +L+ V + E K+ EI+D+ +L
Sbjct: 1187 LQHEATAAT----LRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEAL 1242
Query: 482 QEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEIT------VSFL 535
+ + + V+ Q ++ +++ +++ DL + A +T+ E++ S +
Sbjct: 1243 SKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLI 1302
Query: 536 QKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQ 595
++T + L QQ E+ ++Q+E+E K + + + R YEE Q
Sbjct: 1303 SQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQ 1362
Query: 596 LQLDA--FEVEKQALLNEHGAAQ--EQLNKIRDSYAKLL--GHQNLKQKIKHVVKLKDEN 649
L EV + E A Q E+L + + A+ L +N + L+
Sbjct: 1363 RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTETANSKCASLEKTK 1422
Query: 650 SQLKSEVSKLRCQLAKKK---QSETKLQEELNKVLG--IKHFDPSKA-FHHESKENFALK 703
+L+ EV L L + + K Q +KVL + D S+A KE+ +L
Sbjct: 1423 QRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLS 1482
Query: 704 TPL 706
T L
Sbjct: 1483 TEL 1485
Score = 87.4 bits (215), Expect = 4e-17
Identities = 142/660 (21%), Positives = 284/660 (43%), Gaps = 97/660 (14%)
Query: 45 KQQKESKQNLNVDKDTTLPASARKVKSSESKKESQ--KNDKDLKILEKEIRVLLQERGAQ 102
++Q E +Q + L + +V +K E+ + ++L+ +K++ LQE
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEN 1407
Query: 103 DRRIQDLETELEKMEARLNAA----LREKTSLSANNATLEKQLIELTRTNELLKSKFSEN 158
LEK + RL +R+ ATL+K+ + K K E+
Sbjct: 1408 TETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDES 1467
Query: 159 -----GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
QK R LS EL K+RN E ++ + E + + + Q + + +IA+
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEE----VVDQLETLRRENKNLQEEISDLTEQIAET 1523
Query: 214 EGKLVSIEKEKI---DEKSETEKLLEYIE-EISCASDQVEKYKLDIAQLEENLK----EK 265
L EK K EKS+ + LE +E + ++ + +L+++Q++ L EK
Sbjct: 1524 GKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEK 1583
Query: 266 NDEILSLKQSLEENIVILSKQVEDLNVKCQ----LLEKEKEDHVNRNREHNENLNAEMQN 321
++EI LK++ + L + V D ++ + L+K+ E +N + N +M
Sbjct: 1584 DEEIEQLKRNSQRAAEAL-QSVLDAEIRSRNDALRLKKKMEGDLNEMEIQLGHSNRQMAE 1642
Query: 322 LKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQ 381
++ Q + L+ +L +D L+ ++L L +V+ +N
Sbjct: 1643 TQKHLRTVQGQ---LKDSQLHLDDALRSNEDLKEQL---------AIVERRNGL------ 1684
Query: 382 TLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLL 441
L+EL++++ EQ ER + E+E ++ ++LL H+Q T L
Sbjct: 1685 LLEELEEMKVALEQTERTRRLSEQELLDASDRVQLL-----------------HSQNTSL 1727
Query: 442 LQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILA 501
+ K + LE AQ ++ E+E+ E+ + +EKA KA +A + ++
Sbjct: 1728 INTK-----KKLEADIAQCQA-------EVENSIQESRNAEEKAKKAITDAAMMAEELKK 1775
Query: 502 TESSNQEYVRMLLDL-QTKSALKE--TEIKEITVSFLQK-ITDLQNQLKQQEEDFRKQLE 557
+ ++ RM +L QT L+ E +++ + +K I L+N++++ E +L+
Sbjct: 1776 EQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLENRVRELE----NELD 1831
Query: 558 DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
E+ R AE + ++ + EE + Q +D + + ++ + A+E
Sbjct: 1832 VEQKRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEE 1891
Query: 618 QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQL-KSEVSKLRCQLAKKKQSETKLQEE 676
Q N + ++++H ++ E + + +S+V+KLR AK + ++ EE
Sbjct: 1892 QANT----------QLSRCRRVQHELEEAAERADIAESQVNKLR---AKSRDVGSQKMEE 1938
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 114 bits (285), Expect = 3e-25
Identities = 166/707 (23%), Positives = 319/707 (45%), Gaps = 93/707 (13%)
Query: 27 KTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLK 86
+ LE L+G S ++ + +E+ + +D A K + +E+ +++ +L+
Sbjct: 666 RQLEQLEGKRSVL-AKELVEVREALSRATLQRDML---QAEKAEVAEALTKAEAGRVELE 721
Query: 87 ILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELT- 145
+ ++R A++ +QD L K+ A + ++K L+ A LE++ L
Sbjct: 722 LSMTKLR-------AEEASLQD---SLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQG 771
Query: 146 RTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEE 205
R + + Q+ L L LE R E +R QE +E +L + +
Sbjct: 772 RQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQ 831
Query: 206 SQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEK------YKLDIAQLE 259
Q ++AQL +L E+E + E ++ +E +E + + + K +L A+ E
Sbjct: 832 LQEQLAQLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAERE 891
Query: 260 -ENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAE 318
L E+ + K++LE ++ + +Q+ L + + LE E + + E L E
Sbjct: 892 GRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAEGQALLLAK----ETLTGE 947
Query: 319 MQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEE---MVKEKNLF 375
+ L+Q+ I+ QE+ L KEL L+Q E+E +SL ++ + +E+ + +EK
Sbjct: 948 LAGLRQQ-IIATQEKASLD-KELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAA 1005
Query: 376 EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLL----EEKLKGKEAELEKS 431
EL+ +L Q+E+ E L+ +LE E + +EE+ L +E L E+E +++
Sbjct: 1006 WRELEAERAQLQSQLQREQ--EELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQA 1063
Query: 432 SAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK---------------ALTASEIEDLKL 476
+ L EK SL ++ + E K ALT SE+ DL+
Sbjct: 1064 LSLKESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALT-SELRDLRA 1122
Query: 477 ENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQ 536
+ +E+AA A +A++V+ QE R L Q S L+E E + L+
Sbjct: 1123 Q----REEAAAA--HAQEVRRL--------QEQARD-LGKQRDSCLREAEELRTQLRLLE 1167
Query: 537 KITD-LQNQLKQQEEDFRKQLEDEEGRKAEKE------NTTAELTEEINKWRLLYEELYN 589
D L+ +L + + RK E +EGR+ +++ + E +E R EEL +
Sbjct: 1168 DARDGLRRELLEAQ---RKLRESQEGREVQRQEAGELRRSLGEGAKEREALRRSNEELRS 1224
Query: 590 KTKPFQLQLDAFEV------EKQALLNE-HGAAQEQLNKIRDSY-----AKLLGHQNLKQ 637
K + + + ++ +K ALL E A ++ ++R ++L + L++
Sbjct: 1225 AVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQE 1284
Query: 638 KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKVLGIK 684
+ + L EN++L E+++L+ +LA +++E +E + LG++
Sbjct: 1285 LRRQMKMLDSENTRLGRELAELQGRLALGERAE---KESRRETLGLR 1328
Score = 90.5 bits (223), Expect = 5e-18
Identities = 132/678 (19%), Positives = 282/678 (41%), Gaps = 95/678 (14%)
Query: 39 QKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKND-----KDLKILEKEIR 93
Q++ ++++E + L ++++ ++ +E +E+ + + L++++
Sbjct: 778 QEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLA 837
Query: 94 VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 153
L ++ +++ ++ E ++ L A REK +L+ +A L QL+ R L
Sbjct: 838 QLSRQLSGREQELEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTL-- 895
Query: 154 KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
SE + L +LE +R+ + + A++E +E + Q + E G++A L
Sbjct: 896 --SEEATRLRLEKEALEGSLFEVQRQ--LAQLEARREQLEAEGQALLLAKETLTGELAGL 951
Query: 214 EGKLVSI-EKEKIDEKSETEKLLEYIEEISCA-SDQVEKYKLDI---------------- 255
++++ EK +D++ +KL++ E + +Q ++ D+
Sbjct: 952 RQQIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEA 1011
Query: 256 --AQLEENLKEKNDEILSL----KQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNR 309
AQL+ L+ + +E+L+ K+ L E I L ++ ++ L E EK+ ++
Sbjct: 1012 ERAQLQSQLQREQEELLARLEAEKEELSEEIAALQQERDE---GLLLAESEKQQALSLKE 1068
Query: 310 EHNENLNAEMQNLKQKFI-----LEQQEREKLQQKEL----------QIDSLLQQEKELS 354
L+ ++ + +E+Q+R+ ++E ++ L Q +E +
Sbjct: 1069 SEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAA 1128
Query: 355 SSLHQKLCSFQEEM----------VKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLE 404
++ Q++ QE+ ++E +L+ D D L+++ +A+R +++ +
Sbjct: 1129 AAHAQEVRRLQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQ 1188
Query: 405 EEAKSRAEEL----KLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVT--- 457
E + + +E + L E K +EA L +S+ A + + S+ + ED
Sbjct: 1189 EGREVQRQEAGELRRSLGEGAKEREA-LRRSNEELRSAVKKAESERISLKLANEDKEQKL 1247
Query: 458 AQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQ 517
A E + E +L+ ++ +A + ++++ Q+ +S N R L +LQ
Sbjct: 1248 ALLEEARTAVGKEAGELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQ 1307
Query: 518 TKSALKETEIKEITVSFL-----------------QKITDLQNQLKQQEEDFRKQLEDEE 560
+ AL E KE L Q++ Q +L++QE +FR +
Sbjct: 1308 GRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLL 1367
Query: 561 GRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNE-------HG 613
G E T + + L E + L+L A E Q L E
Sbjct: 1368 GSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRR 1427
Query: 614 AAQEQLNKIRDSYAKLLG 631
AA+ QL +R + + LG
Sbjct: 1428 AAEAQLGGLRSALRRGLG 1445
Score = 84.3 bits (207), Expect = 4e-16
Identities = 151/697 (21%), Positives = 300/697 (43%), Gaps = 111/697 (15%)
Query: 60 TTLPASARKVKSSE-SKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEA 118
T+LPA R++ + S+ ES L E + LQE Q L+ EL ++E
Sbjct: 45 TSLPALIREIVTRNLSQPESPVL---LPATEMASLLSLQEEN------QLLQQELSRVED 95
Query: 119 RLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMK-LRNK 177
L + E+ L+ + ++L + R L+ E + L S+EL + L+ +
Sbjct: 96 LLAQSRAERDELAIKYNAVSERLEQALR----LEPGELETQEPRGLVRQSVELRRQLQEE 151
Query: 178 RETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKL--- 234
+ + R + A QEG + + Q+ QR QGKI Q + + +E++ ++ E E+
Sbjct: 152 QASYRRKLQAYQEGQQRQAQLVQRL----QGKILQYKKRCSELEQQLLERSGELEQQRLR 207
Query: 235 -LEYIEEISCASDQVEKYK---LDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDL 290
E+ +++ A ++E+ + +AQ+ L+E+ D+ S Q+L E+I ++V +
Sbjct: 208 DTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDI----RKVTND 263
Query: 291 NVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQ----------------ERE 334
+C+ KE E R E+ NA N + +L + ER+
Sbjct: 264 WTRCR---KELEHREAAWRREEESFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERD 320
Query: 335 KLQ------------------------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
LQ E + ++ L+++ L + L ++L ++++++
Sbjct: 321 LLQLGGELARTSRAVQEAGLGLSTGLRLAESRAEAALEKQALLQAQLEEQL---RDKVLR 377
Query: 371 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEA-ELE 429
EK+L +++++ LD+ D L + + VK+LE++ + + K L EKL+ E+ L+
Sbjct: 378 EKDLAQQQMQSDLDKAD-LSARVTELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQ 436
Query: 430 KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASE---------IEDLKLENSS 480
+ +A T+ LQ+ + Q+ V + ES L+ SE + L + +
Sbjct: 437 EQAALETEDGEGLQQTLRDLAQA---VLSDSESGVQLSGSERTADASNGSLRGLSGQRTP 493
Query: 481 LQEKAAKAGKNAEDVQHQILA-TESSNQEYVRMLL---DLQTKSALKETEIKEITVSFLQ 536
+ + G+ + A ++SS + L LQ + E + + L+
Sbjct: 494 SPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQLQVQDMRGRYEASQDLLGTLR 553
Query: 537 K-ITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQ 595
K ++D +++ + EE ++ + +G E+ E+ + LL E N Q
Sbjct: 554 KQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQ 613
Query: 596 L---QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAK---------LLGHQNLKQKIKHVV 643
+ Q + E++ L AAQE+L + RD + + L++ + +
Sbjct: 614 VAQQQAEELRQEREKL----QAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLE 669
Query: 644 KLKDENSQLKSEVSKLRCQLAKKKQSETKLQEELNKV 680
+L+ + S L E+ ++R L++ LQ E +V
Sbjct: 670 QLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAEV 706
Score = 79.0 bits (193), Expect = 1e-14
Identities = 127/635 (20%), Positives = 267/635 (42%), Gaps = 74/635 (11%)
Query: 69 VKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRI--QDLETELEKMEARLNAALRE 126
++ +ES+ E+ + L L+ ++ L+++ +++ + Q ++++L+K A L+A +
Sbjct: 346 LRLAESRAEAALEKQAL--LQAQLEEQLRDKVLREKDLAQQQMQSDLDK--ADLSARV-- 399
Query: 127 KTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMM 186
T L LEKQ +E + N+ L K + + +LE ++T
Sbjct: 400 -TELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQ 458
Query: 187 AKQEGMEMKLQVT--QRSLEESQGKIAQLEGKLVSIEKEKIDE------KSETEKLLEYI 238
A E +Q++ +R+ + S G + L G+ + +
Sbjct: 459 AVLSDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDS 518
Query: 239 EEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSL---EENIVILSKQVEDLNVKCQ 295
++ + K +L + + + D + +L++ L E L +Q++ L K
Sbjct: 519 STLALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTD 578
Query: 296 LLEKEKED---HVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKE 352
+ ED V R R NE L+ E NL + QQ+ E+L+Q+
Sbjct: 579 GAMQAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQER------------ 626
Query: 353 LSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE 412
+KL + QEE+ ++++ EEE + + + +++++ E++ R ++QLE + A+
Sbjct: 627 ------EKLQAAQEELRRQRDRLEEEQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAK 680
Query: 413 ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIE 472
EL + E L S A Q +L EK + + + E ++T E
Sbjct: 681 ELVEVREAL----------SRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAE 730
Query: 473 DLKLEN-----SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEI 527
+ L++ S+L E A+ + + Q+ +S+ Q R T + ++ +
Sbjct: 731 EASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEEKSALQGRQRQAEQEATVAREEQERL 790
Query: 528 KEITVSFLQKITDLQNQLK---QQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLY 584
+E+ + L+ L+ Q +E +QL +++ + A+L+ +++
Sbjct: 791 EELRLEQEVARQGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGRE--- 847
Query: 585 EELYNKTKPFQLQLDAFE---VEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKH 641
+EL + Q Q++A E EK+AL EH QL + + + +
Sbjct: 848 QELEQARREAQRQVEALERAAREKEALAKEHAGLAVQL---------VAAEREGRTLSEE 898
Query: 642 VVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676
+L+ E L+ + +++ QLA+ + +L+ E
Sbjct: 899 ATRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE 933
Score = 79.0 bits (193), Expect = 1e-14
Identities = 105/531 (19%), Positives = 232/531 (43%), Gaps = 26/531 (4%)
Query: 16 GCAPSPGAYDVKTLEVLKGPVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESK 75
G A SP + D+ E ++G + + F Q+ S Q + T A R++ E++
Sbjct: 1492 GPATSPASPDLDP-EAVRGAL-----REFLQELRSAQRERDELRTQTSALNRQLAEMEAE 1545
Query: 76 KESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNA 135
++S + + L+K + + R + D R+ ++ EL E + + RE+ + A
Sbjct: 1546 RDSATSRA--RQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVA 1603
Query: 136 TLEKQLIELTRTNELLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEM 194
TLE+ L + K S+ N+ L L ++ + E++ + ++ +E
Sbjct: 1604 TLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEG 1663
Query: 195 KLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLD 254
+LQ ++ L + + + L+ ++ S++++ D + + L +E ++ A +VE+ +
Sbjct: 1664 ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGA 1723
Query: 255 IAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE---DHVNRNREH 311
+ L E + + S + + L K + Q+L++ + ++ R+
Sbjct: 1724 LRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQ 1783
Query: 312 NENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKE 371
+ +L ++Q L+ + + +R + + + Q+ +L+Q +E ++ + Q+ E
Sbjct: 1784 SSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQD----E 1839
Query: 372 KNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEEL-KLLEEKLKGKE----- 425
+ L +E L L +L+ ++ + ER +LE++ + L K+ EKL+ E
Sbjct: 1840 RRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRL 1899
Query: 426 -AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEK 484
AE + T A L L E +Q LE E + E+ D + + LQ++
Sbjct: 1900 SAEKGRLDRTLTGAELELAEA-QRQIQQLEAQVVVLEQSHSPAQLEV-DAQQQQLELQQE 1957
Query: 485 AAKAGKNAEDVQHQILATESSNQEYVRMLLD-LQTKSALKETEIKEITVSF 534
+ + + A E ++++ VR L + + T + E++ + F
Sbjct: 1958 VERLRSAQAQTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 114 bits (284), Expect = 4e-25
Identities = 143/636 (22%), Positives = 288/636 (45%), Gaps = 70/636 (11%)
Query: 66 ARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALR 125
++K + + ++++K+++ L I LLQE+ + LE E+E++ + +
Sbjct: 1337 SKKREERWMRASKRQSEKEMEELHHNIDDLLQEK-------KSLECEVEELHRTVQKRQQ 1389
Query: 126 EKTSLSANNATLEKQLIELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGM 185
+K + N +L +L E+ KS + + L+K R++ R +
Sbjct: 1390 QKDFIDGNVESLMTEL-------EIEKSLKHHEDIVDEIECIEKTLLKRRSELREADRLL 1442
Query: 186 MAKQEGMEMKLQVTQRSLE---ESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEIS 242
+ + + T+ ++E +++ + Q E +E+ + K + + +
Sbjct: 1443 AEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQ 1502
Query: 243 CASDQVEKYKLDIAQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKE 302
+ +E++K+ + EE LKE N +I++ K S + LSK+ E L + Q L+K+ E
Sbjct: 1503 ADAKDLEQHKI---KQEEILKEIN-KIVAAKDS---DFQCLSKKKEKLTEELQKLQKDIE 1555
Query: 303 DHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLC 362
RN +H+ +Q LK+ +L Q +R +L++ + Q+ S Q+ L L K
Sbjct: 1556 -MAERNEDHH------LQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKK- 1607
Query: 363 SFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLK 422
+E +L + + Q +L ++A RL + E + E+K L E+L
Sbjct: 1608 -------EELHLLQGSMVQAKADL-------QEALRLGETEVTEKCNHIREVKSLLEELS 1653
Query: 423 GKEAELE-KSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL 481
++ EL + S TQ TL+ QE + ++L+ V Q +K + ++ L+LEN L
Sbjct: 1654 FQKGELNVQISERKTQLTLIKQE-IEKEEENLQVVLRQMSKHKTELKNILDMLQLENHEL 1712
Query: 482 Q-------EKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEI--TV 532
Q ++ ++ K V + L E+ Q + +++ + L E + +EI
Sbjct: 1713 QGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQKQLLERDKREIERMT 1772
Query: 533 SFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTK 592
+ + + L +++ED +++ + E + A+ + A E + E+L +
Sbjct: 1773 AESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR 1832
Query: 593 PFQLQLDAFEVEKQALLNEHGAAQEQL-------NKIRDSYAKLLGHQNL-KQKIKHVVK 644
Q +LD +K +L N+ A Q+QL N +++ A + H NL KQ + H K
Sbjct: 1833 KLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTK 1892
Query: 645 LKD----ENSQLKSEVSKLRCQLAK-KKQSETKLQE 675
+D E ++L+ ++S+ + +K+ ETK Q+
Sbjct: 1893 HQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQ 1928
Score = 108 bits (270), Expect = 2e-23
Identities = 152/677 (22%), Positives = 311/677 (45%), Gaps = 81/677 (11%)
Query: 39 QKSQRFKQQKESKQNLNVDK-DTTLPASARKVKSSESKKESQKNDKDLKIL-------EK 90
+K ++ K + L+ K + + S RK + + K+E +K +++L+++ +
Sbjct: 1637 EKCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKT 1696
Query: 91 EIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNEL 150
E++ +L ++ +Q L+ + ++ + L EKT + A LE++L EL ++
Sbjct: 1697 ELKNILDMLQLENHELQGLKLQHDQRVSEL-----EKTQV----AVLEEKL-ELENLQQI 1746
Query: 151 LKSKFSENGNQKNLRILSLELMKLRNKRET-KMRGMMAKQEGMEMKLQVTQRSLEESQGK 209
+ + E QK L LE K +R T + R + + E + + + Q + + K
Sbjct: 1747 SQQQKGEIEWQKQL----LERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKK 1802
Query: 210 IAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKL----DIAQLEENLKEK 265
+AQ + L + E+ E+S EKL + ++ DQ+ + KL DI+ +++ L+EK
Sbjct: 1803 LAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEK 1862
Query: 266 NDEILSLKQSL----------EENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 315
+ + SL++ L +++++ +K + L + L+K+ + NR E+
Sbjct: 1863 REAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWANRF----EDC 1918
Query: 316 NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 375
E + +Q+ + Q E E+ + K +Q + + Q+ ++ S KL + + + ++++
Sbjct: 1919 QKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQL 1978
Query: 376 EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
E+EL +LD++ K AE V+ L+EE + E L+ + K + +E E+
Sbjct: 1979 EKELTDQKSKLDQVLSKVLAAEERVRTLQEEER-WCESLEKTLSQTKRQLSEREQQLVEK 2037
Query: 436 TQATLLLQEKYDSMVQSLEDVTAQF--ESYKA--LTASEIEDLKLENSSLQEKAAKAGKN 491
+ L LQ++ DSM + QF E KA AS E LK++ S L++ + +
Sbjct: 2038 SGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQE 2097
Query: 492 AEDVQHQILATE---SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQ 548
+Q ++ E N E R L+ E+ ++ + T+L+ Q+ Q
Sbjct: 2098 NSCIQKEMATIELVAQDNHERARRLM----------KELNQMQYEY----TELKKQMANQ 2143
Query: 549 EEDFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEEL-------YNKTKPFQLQLDAF 601
++ R+Q+E + + K E+ + EL + + + +L++
Sbjct: 2144 KDLERRQMEISDAMRTLKSEVKDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESL 2203
Query: 602 EVEKQALLNEHGAAQEQLN----KIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVS 657
+ +NE G +E+LN I D + + + L++K++H + +QL+ +S
Sbjct: 2204 KENLPFTMNE-GPFEEKLNFSQVHIMDEHWR---GEALREKLRH--REDRLKAQLRHCMS 2257
Query: 658 KLRCQLAK-KKQSETKL 673
K L K K+Q+E L
Sbjct: 2258 KQAEVLIKGKRQTEGTL 2274
Score = 106 bits (264), Expect = 9e-23
Identities = 141/682 (20%), Positives = 309/682 (45%), Gaps = 73/682 (10%)
Query: 49 ESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKILEKEIRVLLQERGAQDRRIQD 108
E++ L+ K+ T A + + S +++ + ++L+ +E V L + Q R +Q
Sbjct: 1444 EAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVKADQQLRSLQA 1503
Query: 109 LETELEKMEARLNAALREKTSLSANNAT----LEKQLIELTRTNELLKS--KFSENGNQK 162
+LE+ + + L+E + A + L K+ +LT + L+ + +E
Sbjct: 1504 DAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDH 1563
Query: 163 NLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKLVSIEK 222
+L++L + L+ KR ++ + ++ + ++ V R L + ++ L+G +V +
Sbjct: 1564 HLQVLKESEVLLQAKR-AELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKA 1622
Query: 223 E-----KIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLKQSL- 276
+ ++ E TEK +I E+ +++ K +L + E+ ++ +KQ +
Sbjct: 1623 DLQEALRLGETEVTEK-CNHIREVKSLLEELSFQK---GELNVQISERKTQLTLIKQEIE 1678
Query: 277 --EENIVI----LSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
EEN+ + +SK +L +L+ E + +H++ + +E++ + + E+
Sbjct: 1679 KEEENLQVVLRQMSKHKTELKNILDMLQLENHELQGLKLQHDQRV-SELEKTQVAVLEEK 1737
Query: 331 QEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFE-------EELKQTL 383
E E LQQ Q ++ +K+L +++ E M E + +E +
Sbjct: 1738 LELENLQQISQQQKGEIEWQKQLLERDKREI----ERMTAESRALQSCVECLSKEKEDLQ 1793
Query: 384 DELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSS----AAHTQAT 439
++ D ++K Q +R++ EE +K L+ LE ++ + EL++ + + H +
Sbjct: 1794 EKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDIS 1853
Query: 440 LL---LQEKYDSMVQSLEDVTAQFESYKALTASEI------EDLKL-ENSSLQEKAAKAG 489
+ LQEK ++ V SL++ A + + L ++ +D+ L E + LQ+ ++
Sbjct: 1854 AMQQQLQEKREA-VNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRLQKDISEWA 1912
Query: 490 KNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQ----- 544
ED Q + E + Q+ +++L + ++ LK + +E+ LQK + +
Sbjct: 1913 NRFEDCQKE----EETKQQQLQVLQNEIEENKLKLVQ-QEMMFQRLQKERESEESKLETS 1967
Query: 545 ---LKQQEEDFRKQLEDEEGR------KAEKENTTAELTEEINKWRLLYEELYNKTKPFQ 595
LK+Q+ K+L D++ + K +E +W E+ ++TK
Sbjct: 1968 KVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQL 2027
Query: 596 LQLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSE 655
+ + VEK E A Q++ + +R ++ LL +Q L ++ K ++ LK +
Sbjct: 2028 SEREQQLVEKS---GELLALQKEADSMRADFS-LLRNQFLTERKKAEKQVASLKEALKIQ 2083
Query: 656 VSKLRCQLAKKKQSETKLQEEL 677
S+L L ++KQ + +Q+E+
Sbjct: 2084 RSQLEKNLLEQKQENSCIQKEM 2105
Score = 88.2 bits (217), Expect = 2e-17
Identities = 125/557 (22%), Positives = 238/557 (42%), Gaps = 54/557 (9%)
Query: 39 QKSQRFKQQKESKQ-NLNVDKDTTLPASARKVKSSESKKESQKN--DKDLKILEKEIRVL 95
QK + +QKE K + +D + +K+ +S KE Q + +K + LE + +
Sbjct: 522 QKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEI 581
Query: 96 LQERGAQDRRIQDLETELEKMEARLNAALREKT------------SLSANNATLEKQLIE 143
L + I+DLE +L + + N AL++ ++ + + +
Sbjct: 582 LSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRK 641
Query: 144 LTRTNELLKSKFSENGNQKN-LRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRS 202
L E L + +E +++ L I++++ +R K ++ + +Q + LQ TQ
Sbjct: 642 LRDEKETLLQRLTEVEQERDQLEIVAMDAENMR-KELAELESALQEQHEVNASLQQTQGD 700
Query: 203 LEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIE-EISCASDQVEKYK------LDI 255
L + A+LE +L + E K E EK+ + E S ++EK + L
Sbjct: 701 LSAYE---AELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGK 757
Query: 256 AQLEENLKEKNDEILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENL 315
AQ E +++N E+ + + L+++ +L +Q++D + +HV E +
Sbjct: 758 AQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDF--------QNHLNHVVDGLVRPEEV 809
Query: 316 NAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLF 375
A + L++K L E ++ SL +K+ S L + E V+E+ L
Sbjct: 810 AARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKL- 868
Query: 376 EEELKQTLDELDKLQQKEEQA-ERLV--------KQLEEEAKSRAEELKLLEEKLKGKE- 425
+EE+ ++L Q++ QA ER + +Q E + E+ L+E LK E
Sbjct: 869 QEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEE 928
Query: 426 ----AELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSL 481
+L+ A + +L Q + + LED +Q + + E++ LK ++
Sbjct: 929 IQGLTDLQLQEADEEKERILAQLRELEKKKKLEDAKSQEQVFGL--DKELKKLKKAVATS 986
Query: 482 QEKAAKAGKNAEDVQHQILATESS-NQEYVRMLLDLQTKSALKETEIKEITVSFLQKITD 540
+ A A+D + T NQE L + + S +++T + + I
Sbjct: 987 DKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAE-IEL 1045
Query: 541 LQNQLKQQEEDFRKQLE 557
LQN L+Q+ E FR ++E
Sbjct: 1046 LQNLLRQKGEQFRLEME 1062
Score = 79.7 bits (195), Expect = 9e-15
Identities = 155/758 (20%), Positives = 315/758 (41%), Gaps = 94/758 (12%)
Query: 24 YDVKTLEVLKG-PVSFQKSQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQKND 82
+ +++LE L+G PV+ Q Q ++ ++ +++D + +++ E K + +
Sbjct: 242 FHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDL----EKKMIETEELKSKQTRFL 297
Query: 83 KDLKILEKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI 142
+++K +K + L +E Q + ++L+++L L E T LE++L
Sbjct: 298 EEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELA 357
Query: 143 --ELTRTNELLKSKFSENGNQKNLRILSLELMKLRNKRET---------KMRGMMAKQEG 191
++ E L SE S + K R KR + + K+
Sbjct: 358 FYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKME 417
Query: 192 MEMKLQVTQRSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKY 251
+ +L+ +L QLE +KEK ++T +L E +EI A Q+ +
Sbjct: 418 PDEQLRNDHMNLRGHTPLDTQLE------DKEKKISAAQT-RLSELHDEIEKAEQQILRA 470
Query: 252 KLDIAQLEENLKEKNDEILS---LKQSLEENIVILSK-QVEDLNVKCQLLEKEKEDHVNR 307
+ QLEE ++ K L + L + +++K + E L+++ Q+ EK+K++ +
Sbjct: 471 TEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQM-EKQKQEIAGK 529
Query: 308 NREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEE 367
+E + L + +L K + + KE Q+D + +Q ++L S L + L +E
Sbjct: 530 QKEIKD-LQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKE 588
Query: 368 MVKEKNLFE----------EELKQTLDE--------LDKLQQKEEQAERLVKQLEEEAKS 409
+ K+L E E LK+ L+ L ++ + QA+ ++L +E ++
Sbjct: 589 TEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKET 648
Query: 410 RAEELKLLEEK-----LKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYK 464
+ L +E++ + +AE + A ++ L Q + ++ SL+ +Y+
Sbjct: 649 LLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNA---SLQQTQGDLSAYE 705
Query: 465 ALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKE 524
A + + E + L+E+ K + + Q + A ++ ++ L S KE
Sbjct: 706 AELEARLNLRDAEANQLKEELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKE 765
Query: 525 TEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRKAEKENTTAELTEEINKWRL-- 582
E E+ L+ + D N LKQQ +DF+ L E A + E K +L
Sbjct: 766 QENSELHAK-LKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGT 824
Query: 583 -----------LYEELYNKTKPF-------QLQLDAFEVEKQALLNEHGAAQEQL----N 620
L + L + K F + + D +V ++ L E QE+L
Sbjct: 825 GEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQE 884
Query: 621 KIRDSYAKLL---------GHQNLKQKIKHVVKLKDENSQLKSEVSKLR-CQLAKKKQSE 670
+ R + + L H+ Q++++ + EN + E+ L QL + + +
Sbjct: 885 EFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEK 944
Query: 671 TKLQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
++ +L ++ K + +K+ ++ F L LK+
Sbjct: 945 ERILAQLRELEKKKKLEDAKS----QEQVFGLDKELKK 978
Score = 30.0 bits (66), Expect = 7.9
Identities = 26/142 (18%), Positives = 61/142 (42%), Gaps = 14/142 (9%)
Query: 540 DLQNQLKQQEE---DFRKQLEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQL 596
+L+N++ + E+ + + +E +A K + E+ EEL++
Sbjct: 1320 NLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEM-----------EELHHNIDDLLQ 1368
Query: 597 QLDAFEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEV 656
+ + E E + L Q+Q + I + L+ +++ +KH + DE ++ +
Sbjct: 1369 EKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTL 1428
Query: 657 SKLRCQLAKKKQSETKLQEELN 678
K R +L + + + + EL+
Sbjct: 1429 LKRRSELREADRLLAEAESELS 1450
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 113 bits (283), Expect = 5e-25
Identities = 154/722 (21%), Positives = 309/722 (42%), Gaps = 89/722 (12%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQK--NDKDLKILEKEIR--VLL 96
SQ +++ ++ L + + A +V+ + K+E ++ ++ + ++ E+E R L
Sbjct: 883 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942
Query: 97 QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRTNE 149
ER +++ DLE +LE+ EA EK + A LE +++ +L++ +
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 150 LLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
LL+ + S+ N + L KL+NK E+ + +E++L+ ++S +E +
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEK 1055
Query: 209 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
+LEG ++ D +++ +L + + + E+ + +A+L++ + +KN+
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1109
Query: 269 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFIL 328
+ +++ LE +I L + ++ EK+K D E E L E+++
Sbjct: 1110 LKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRD----LGEELEALKTELEDTLDSTAT 1164
Query: 329 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
+Q+ R K +Q+ + L +E + Q++ + V+E E+ K+ LDK
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 389 LQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 447
+Q E++ L +L +++ +E++ ++KL+ + EL+ + +A L +K
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 448 SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 507
+ +E VT + + KA K K+ + Q+ T+ Q
Sbjct: 1284 KLQNEVESVTGML------------------NEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 508 EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN------QLKQQEEDFRKQLED--- 558
E R L++ TK E E + +++ QN L Q D +K+L+D
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 559 -----EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 613
EEG+K + LT++ + Y++L Q +LD V+ L+
Sbjct: 1386 TVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD----LDNQR 1440
Query: 614 AAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQLKSEVSKLRCQ---LAKKKQS 669
L K + + +LL + N+ K DE + ++E + + LA+ +
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISS------KYADERDRAEAEAREKETKALSLARALEE 1494
Query: 670 ETKLQEEL---NKVLGIK-------HFDPSKAFHHESKENFALKTPLKEGNTNCYRAPME 719
+ +EEL NK+L + D K H K AL+T ++E T E
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 720 CQ 721
Q
Sbjct: 1555 LQ 1556
Score = 110 bits (275), Expect = 5e-24
Identities = 137/658 (20%), Positives = 292/658 (44%), Gaps = 50/658 (7%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKS------SESKKESQKNDKDLKILEKEIR 93
K ++ +++ S N+ ++ + K+K+ SE + +K +K + LEK R
Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 94 VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 153
L + +I DL+ ++ +++ +L +++ L A A L+ E+ + N LK
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQL---AKKEEELQAALARLDD---EIAQKNNALKK 1112
Query: 154 KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
G+ +L+ RNK E + R + + E ++ +L+ T S Q A+
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 214 EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
E + V++ K+ +DE++ + + QV++ + AQ E L E+ ++ K
Sbjct: 1173 EQE-VTVLKKALDEETRSHEA------------QVQEMRQKHAQAVEELTEQLEQFKRAK 1219
Query: 274 QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
+L++N L K+ DL + ++L + K++ ++ ++ L A++Q L+ K ++ R
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK----LEAQVQELQSKCSDGERAR 1275
Query: 334 -------EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 386
KLQ + + +L + + + L + + S ++ + L +EE +Q L+
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335
Query: 387 DKLQQKEEQAERLVKQLEE--EAKSRAEE----LKLLEEKLKGKEAELEKSSAAHTQATL 440
KL+Q EE+ L QL+E EAK E L + K K + + A +
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395
Query: 441 LLQEKYDSMVQSLEDVTAQF---ESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH 497
Q++ +++ Q E+ A + E K E++DL ++ + ++ + K
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Query: 498 QILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 557
+ ++ + +Y + ++ KET+ + + L++ + + +L++ + + ++E
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKMLKAEME 1514
Query: 558 DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
D K + EL + EE+ + + + +L A E K L A +
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 618 QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
Q RD A+ QN +++ + +L + ++L+ E + A KK+ E L++
Sbjct: 1575 QFE--RDLQAR--DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Score = 105 bits (263), Expect = 1e-22
Identities = 139/662 (20%), Positives = 294/662 (44%), Gaps = 94/662 (14%)
Query: 47 QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKI-----LEKEIRVLLQERGA 101
Q+E++Q LNV + K++ E ++ S ++ D ++ LE+ I L +
Sbjct: 1325 QEETRQKLNV---------STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 102 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN--- 158
+++QD + +E +E +E +L+ +L +T L+ + +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 159 -GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 217
NQ+ L + +LE K++ K ++A+++ + K +R E++ + + E K
Sbjct: 1436 LDNQRQL-VSNLE------KKQRKFDQLLAEEKNISSKY-ADERDRAEAEAR--EKETKA 1485
Query: 218 VSIEK---EKIDEKSETEK----LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 270
+S+ + E ++ K E E+ L +E++ + D V K ++ + + L+ + +E+
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 271 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
+ + LE+ + L V Q L+ + E + E NE ++Q ++ E
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 331 QEREKLQ------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 384
++ K + +K+L+ D L E + S++ + EE +K+ + ++K
Sbjct: 1606 EDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGR-----EEAIKQLRKLQAQMKDFQR 1659
Query: 385 ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG-----KEAELEKSSAAHTQAT 439
EL+ + ++ K+ E++AKS +L L+E L K+A+LEK A A+
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719
Query: 440 LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
L S +L+D + E+ A E+E+ + ++ ++ KA + AE + ++
Sbjct: 1720 SL------SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE- 1772
Query: 500 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
LATE S QK + QL++Q ++ R +L +
Sbjct: 1773 LATERST----------------------------AQKNESARQQLERQNKELRSKLHEM 1804
Query: 560 EGR-KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 618
EG K++ ++T A L +I + L E++ + + Q + + +K L E E
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQ---LEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVED 1860
Query: 619 LNKIRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676
K+ + Y + G+ +KQ + + + ++E+ ++ + KL+ +L + +S + E
Sbjct: 1861 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920
Query: 677 LN 678
+N
Sbjct: 1921 VN 1922
Score = 86.3 bits (212), Expect = 9e-17
Identities = 119/536 (22%), Positives = 249/536 (46%), Gaps = 54/536 (10%)
Query: 172 MKLRN----KRETKMRGMMA---KQEGMEMK---LQVTQRSLEESQGKIAQLEGKLVSIE 221
+KLRN + TK++ ++ ++E M+ K LQ T+ ++++ ++ +LE K +
Sbjct: 827 LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT 886
Query: 222 KEK--IDE--KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND---EILSLKQ 274
+EK + E ++ETE E E + + ++ + + ++E L+E+ D ++ + ++
Sbjct: 887 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 946
Query: 275 SLEENIVILSKQVEDLNVKCQLLEKEK-EDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
+ + ++ L +Q+E+ Q L+ EK + +E L + QN K +ER
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-----SKER 1001
Query: 334 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK- 392
+ L+++ + + L +E+E + +L KL + E M+ E + ++ +++ EL+KL++K
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 393 EEQAERLVKQLEEEAKSRAE---ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 449
E A +Q+ + AE +L EE+L+ A L+ A A ++E +
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 450 VQSLEDVTAQ------FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
ED+ ++ E K E+E LK E + A Q ++ A
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA--------TQQELRAKR 1172
Query: 504 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
++ LD +T+S E +++E+ Q + +L QL+Q F++ + + K
Sbjct: 1173 EQEVTVLKKALDEETRS--HEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNK 1226
Query: 564 AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ--EQLNK 621
E A+L E+ +E+ +K K + Q+ E++ + E A+ ++++K
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHK 1284
Query: 622 IRDSYAKLLGHQNLKQ--KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
+++ + G N + IK + +SQL+ L+ + +K TKL++
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Score = 83.2 bits (204), Expect = 8e-16
Identities = 105/509 (20%), Positives = 216/509 (42%), Gaps = 75/509 (14%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
S ++ +++ + +K+T + AR ++ + E+K+E ++ +K LK +
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 89 EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
K + L + + A + ++++++T+LE++E L A K L N L+ Q
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF------E 1577
Query: 149 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA----KQEG----MEMKLQVTQ 200
L+++ +N ++ L + + E K R + A K EG +E++
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 201 RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 260
+ EE+ ++ +L+ ++ ++E D ++ +++ +E + +E D+ QL+E
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQE 1694
Query: 261 NL-------KEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEKEDHVNRNRE 310
+L K+ + E L + L ++ L + L + LE+E E+
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 311 HNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
++ + Q +Q ER Q+ E L +Q KEL S LH+ E VK
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE-----MEGAVK 1809
Query: 371 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 430
K K T+ L E + QLEE+ + A E + + LK K+ +L++
Sbjct: 1810 SK------FKSTIAAL----------EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 431 SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGK 490
+LLQ V+ + Q++ + ++ LK + +E++ +
Sbjct: 1854 ---------ILLQ------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 491 NAEDVQHQILATESSNQEYVRMLLDLQTK 519
N +Q ++ SN+ R + L++K
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 80.1 bits (196), Expect = 7e-15
Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 32/336 (9%)
Query: 376 EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
EEE++ DEL K ++++++AE +K+LE++ EE LL+E+L +AE E + A
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAE 907
Query: 436 TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 495
L +K Q LE++ + E + +E+ + LQ + K + D+
Sbjct: 908 EMRVRLAAKK-----QELEEILHEME-------ARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 496 QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ 555
+ Q+ E++ Q+ LQ + E +IK++ L + D N+L ++ + ++
Sbjct: 956 EEQLEEEEAARQK-------LQLEKVTAEAKIKKLEDEIL-VMDDQNNKLSKERKLLEER 1007
Query: 556 LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAA 615
+ D AE+E LT+ NK + EL + K + E K+ L +
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 616 QEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE---TK 672
EQ+ ++ A+L Q K +L+ ++L E+++ L K ++ E +
Sbjct: 1068 HEQIADLQAQIAEL-----KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 673 LQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
LQE+L+ ++ K +E ALKT L++
Sbjct: 1123 LQEDLDSERAARN-KAEKQKRDLGEELEALKTELED 1157
Score = 76.3 bits (186), Expect = 1e-13
Identities = 93/420 (22%), Positives = 192/420 (45%), Gaps = 50/420 (11%)
Query: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
KED + + +E + E++ L+QK + E + L Q++LQ ++ L E E + +
Sbjct: 857 KEDELQKTKERQQKAENELKELEQKHS-QLTEEKNLLQEQLQAETELYAEAE---EMRVR 912
Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQ-QKEEQAERLV---KQLEEEAKSRAEELKL 416
L + ++E+ + + E L++ D +LQ ++++ A++++ +QLEEE +R ++L+L
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQL 971
Query: 417 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF--ESYKALTASEIEDL 474
+ + K +LE L ++ + + + D+T E KA +++++
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN- 1030
Query: 475 KLEN--SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT-------KSALKET 525
K E+ S L+ + K K+ ++++ E ++ + DLQ + A KE
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 526 EIKEITVSFLQKITDLQNQLKQQEE------DFRKQLEDEEGRKAEKENTTAELTEEINK 579
E++ +I N LK+ E D ++ L+ E + + E +L EE+
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 580 WRLLYEELYNKTKPFQLQLDA-----FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 634
+ E+ + T Q +L A V K+AL E + + Q+ ++R +A+ + +
Sbjct: 1151 LKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV--EE 1207
Query: 635 LKQKIKHVVKLKDENSQLKSEVSKLRCQLA---------------KKKQSETKLQEELNK 679
L ++++ + K + K + K LA KKK+ E ++QE +K
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 113 bits (283), Expect = 5e-25
Identities = 154/722 (21%), Positives = 309/722 (42%), Gaps = 89/722 (12%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQK--NDKDLKILEKEIR--VLL 96
SQ +++ ++ L + + A +V+ + K+E ++ ++ + ++ E+E R L
Sbjct: 890 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949
Query: 97 QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRTNE 149
ER +++ DLE +LE+ EA EK + A LE +++ +L++ +
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 150 LLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
LL+ + S+ N + L KL+NK E+ + +E++L+ ++S +E +
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEK 1062
Query: 209 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
+LEG ++ D +++ +L + + + E+ + +A+L++ + +KN+
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1116
Query: 269 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFIL 328
+ +++ LE +I L + ++ EK+K D E E L E+++
Sbjct: 1117 LKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRD----LGEELEALKTELEDTLDSTAT 1171
Query: 329 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
+Q+ R K +Q+ + L +E + Q++ + V+E E+ K+ LDK
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 389 LQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 447
+Q E++ L +L +++ +E++ ++KL+ + EL+ + +A L +K
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 448 SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 507
+ +E VT + + KA K K+ + Q+ T+ Q
Sbjct: 1291 KLQNEVESVTGML------------------NEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 508 EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN------QLKQQEEDFRKQLED--- 558
E R L++ TK E E + +++ QN L Q D +K+L+D
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 559 -----EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 613
EEG+K + LT++ + Y++L Q +LD V+ L+
Sbjct: 1393 TVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD----LDNQR 1447
Query: 614 AAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQLKSEVSKLRCQ---LAKKKQS 669
L K + + +LL + N+ K DE + ++E + + LA+ +
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISS------KYADERDRAEAEAREKETKALSLARALEE 1501
Query: 670 ETKLQEEL---NKVLGIK-------HFDPSKAFHHESKENFALKTPLKEGNTNCYRAPME 719
+ +EEL NK+L + D K H K AL+T ++E T E
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 720 CQ 721
Q
Sbjct: 1562 LQ 1563
Score = 110 bits (275), Expect = 5e-24
Identities = 137/658 (20%), Positives = 292/658 (44%), Gaps = 50/658 (7%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKS------SESKKESQKNDKDLKILEKEIR 93
K ++ +++ S N+ ++ + K+K+ SE + +K +K + LEK R
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 94 VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 153
L + +I DL+ ++ +++ +L +++ L A A L+ E+ + N LK
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQL---AKKEEELQAALARLDD---EIAQKNNALKK 1119
Query: 154 KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
G+ +L+ RNK E + R + + E ++ +L+ T S Q A+
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 214 EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
E + V++ K+ +DE++ + + QV++ + AQ E L E+ ++ K
Sbjct: 1180 EQE-VTVLKKALDEETRSHEA------------QVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 274 QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
+L++N L K+ DL + ++L + K++ ++ ++ L A++Q L+ K ++ R
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK----LEAQVQELQSKCSDGERAR 1282
Query: 334 -------EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 386
KLQ + + +L + + + L + + S ++ + L +EE +Q L+
Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342
Query: 387 DKLQQKEEQAERLVKQLEE--EAKSRAEE----LKLLEEKLKGKEAELEKSSAAHTQATL 440
KL+Q EE+ L QL+E EAK E L + K K + + A +
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402
Query: 441 LLQEKYDSMVQSLEDVTAQF---ESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH 497
Q++ +++ Q E+ A + E K E++DL ++ + ++ + K
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Query: 498 QILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 557
+ ++ + +Y + ++ KET+ + + L++ + + +L++ + + ++E
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKMLKAEME 1521
Query: 558 DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
D K + EL + EE+ + + + +L A E K L A +
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 618 QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
Q RD A+ QN +++ + +L + ++L+ E + A KK+ E L++
Sbjct: 1582 QFE--RDLQAR--DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Score = 105 bits (263), Expect = 1e-22
Identities = 139/662 (20%), Positives = 294/662 (44%), Gaps = 94/662 (14%)
Query: 47 QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKI-----LEKEIRVLLQERGA 101
Q+E++Q LNV + K++ E ++ S ++ D ++ LE+ I L +
Sbjct: 1332 QEETRQKLNV---------STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 102 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN--- 158
+++QD + +E +E +E +L+ +L +T L+ + +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 159 -GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 217
NQ+ L + +LE K++ K ++A+++ + K +R E++ + + E K
Sbjct: 1443 LDNQRQL-VSNLE------KKQRKFDQLLAEEKNISSKY-ADERDRAEAEAR--EKETKA 1492
Query: 218 VSIEK---EKIDEKSETEK----LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 270
+S+ + E ++ K E E+ L +E++ + D V K ++ + + L+ + +E+
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 271 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
+ + LE+ + L V Q L+ + E + E NE ++Q ++ E
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 331 QEREKLQ------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 384
++ K + +K+L+ D L E + S++ + EE +K+ + ++K
Sbjct: 1613 EDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGR-----EEAIKQLRKLQAQMKDFQR 1666
Query: 385 ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG-----KEAELEKSSAAHTQAT 439
EL+ + ++ K+ E++AKS +L L+E L K+A+LEK A A+
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726
Query: 440 LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
L S +L+D + E+ A E+E+ + ++ ++ KA + AE + ++
Sbjct: 1727 SL------SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE- 1779
Query: 500 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
LATE S QK + QL++Q ++ R +L +
Sbjct: 1780 LATERST----------------------------AQKNESARQQLERQNKELRSKLHEM 1811
Query: 560 EGR-KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 618
EG K++ ++T A L +I + L E++ + + Q + + +K L E E
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQ---LEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVED 1867
Query: 619 LNKIRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676
K+ + Y + G+ +KQ + + + ++E+ ++ + KL+ +L + +S + E
Sbjct: 1868 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927
Query: 677 LN 678
+N
Sbjct: 1928 VN 1929
Score = 86.3 bits (212), Expect = 9e-17
Identities = 119/536 (22%), Positives = 249/536 (46%), Gaps = 54/536 (10%)
Query: 172 MKLRN----KRETKMRGMMA---KQEGMEMK---LQVTQRSLEESQGKIAQLEGKLVSIE 221
+KLRN + TK++ ++ ++E M+ K LQ T+ ++++ ++ +LE K +
Sbjct: 834 LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT 893
Query: 222 KEK--IDE--KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND---EILSLKQ 274
+EK + E ++ETE E E + + ++ + + ++E L+E+ D ++ + ++
Sbjct: 894 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953
Query: 275 SLEENIVILSKQVEDLNVKCQLLEKEK-EDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
+ + ++ L +Q+E+ Q L+ EK + +E L + QN K +ER
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-----SKER 1008
Query: 334 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK- 392
+ L+++ + + L +E+E + +L KL + E M+ E + ++ +++ EL+KL++K
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 393 EEQAERLVKQLEEEAKSRAE---ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 449
E A +Q+ + AE +L EE+L+ A L+ A A ++E +
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 450 VQSLEDVTAQ------FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
ED+ ++ E K E+E LK E + A Q ++ A
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA--------TQQELRAKR 1179
Query: 504 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
++ LD +T+S E +++E+ Q + +L QL+Q F++ + + K
Sbjct: 1180 EQEVTVLKKALDEETRS--HEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNK 1233
Query: 564 AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ--EQLNK 621
E A+L E+ +E+ +K K + Q+ E++ + E A+ ++++K
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHK 1291
Query: 622 IRDSYAKLLGHQNLKQ--KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
+++ + G N + IK + +SQL+ L+ + +K TKL++
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Score = 83.2 bits (204), Expect = 8e-16
Identities = 105/509 (20%), Positives = 216/509 (42%), Gaps = 75/509 (14%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
S ++ +++ + +K+T + AR ++ + E+K+E ++ +K LK +
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 89 EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
K + L + + A + ++++++T+LE++E L A K L N L+ Q
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF------E 1584
Query: 149 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA----KQEG----MEMKLQVTQ 200
L+++ +N ++ L + + E K R + A K EG +E++
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 201 RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 260
+ EE+ ++ +L+ ++ ++E D ++ +++ +E + +E D+ QL+E
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQE 1701
Query: 261 NL-------KEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEKEDHVNRNRE 310
+L K+ + E L + L ++ L + L + LE+E E+
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 311 HNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
++ + Q +Q ER Q+ E L +Q KEL S LH+ E VK
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE-----MEGAVK 1816
Query: 371 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 430
K K T+ L E + QLEE+ + A E + + LK K+ +L++
Sbjct: 1817 SK------FKSTIAAL----------EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 431 SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGK 490
+LLQ V+ + Q++ + ++ LK + +E++ +
Sbjct: 1861 ---------ILLQ------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 491 NAEDVQHQILATESSNQEYVRMLLDLQTK 519
N +Q ++ SN+ R + L++K
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 80.1 bits (196), Expect = 7e-15
Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 32/336 (9%)
Query: 376 EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
EEE++ DEL K ++++++AE +K+LE++ EE LL+E+L +AE E + A
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAE 914
Query: 436 TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 495
L +K Q LE++ + E + +E+ + LQ + K + D+
Sbjct: 915 EMRVRLAAKK-----QELEEILHEME-------ARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 496 QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ 555
+ Q+ E++ Q+ LQ + E +IK++ L + D N+L ++ + ++
Sbjct: 963 EEQLEEEEAARQK-------LQLEKVTAEAKIKKLEDEIL-VMDDQNNKLSKERKLLEER 1014
Query: 556 LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAA 615
+ D AE+E LT+ NK + EL + K + E K+ L +
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 616 QEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE---TK 672
EQ+ ++ A+L Q K +L+ ++L E+++ L K ++ E +
Sbjct: 1075 HEQIADLQAQIAEL-----KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 673 LQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
LQE+L+ ++ K +E ALKT L++
Sbjct: 1130 LQEDLDSERAARN-KAEKQKRDLGEELEALKTELED 1164
Score = 76.3 bits (186), Expect = 1e-13
Identities = 93/420 (22%), Positives = 192/420 (45%), Gaps = 50/420 (11%)
Query: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
KED + + +E + E++ L+QK + E + L Q++LQ ++ L E E + +
Sbjct: 864 KEDELQKTKERQQKAENELKELEQKHS-QLTEEKNLLQEQLQAETELYAEAE---EMRVR 919
Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQ-QKEEQAERLV---KQLEEEAKSRAEELKL 416
L + ++E+ + + E L++ D +LQ ++++ A++++ +QLEEE +R ++L+L
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQL 978
Query: 417 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF--ESYKALTASEIEDL 474
+ + K +LE L ++ + + + D+T E KA +++++
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN- 1037
Query: 475 KLEN--SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT-------KSALKET 525
K E+ S L+ + K K+ ++++ E ++ + DLQ + A KE
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 526 EIKEITVSFLQKITDLQNQLKQQEE------DFRKQLEDEEGRKAEKENTTAELTEEINK 579
E++ +I N LK+ E D ++ L+ E + + E +L EE+
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 580 WRLLYEELYNKTKPFQLQLDA-----FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 634
+ E+ + T Q +L A V K+AL E + + Q+ ++R +A+ + +
Sbjct: 1158 LKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV--EE 1214
Query: 635 LKQKIKHVVKLKDENSQLKSEVSKLRCQLA---------------KKKQSETKLQEELNK 679
L ++++ + K + K + K LA KKK+ E ++QE +K
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 113 bits (283), Expect = 5e-25
Identities = 154/722 (21%), Positives = 309/722 (42%), Gaps = 89/722 (12%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQK--NDKDLKILEKEIR--VLL 96
SQ +++ ++ L + + A +V+ + K+E ++ ++ + ++ E+E R L
Sbjct: 890 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 949
Query: 97 QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRTNE 149
ER +++ DLE +LE+ EA EK + A LE +++ +L++ +
Sbjct: 950 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 150 LLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
LL+ + S+ N + L KL+NK E+ + +E++L+ ++S +E +
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEK 1062
Query: 209 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
+LEG ++ D +++ +L + + + E+ + +A+L++ + +KN+
Sbjct: 1063 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1116
Query: 269 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFIL 328
+ +++ LE +I L + ++ EK+K D E E L E+++
Sbjct: 1117 LKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRD----LGEELEALKTELEDTLDSTAT 1171
Query: 329 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
+Q+ R K +Q+ + L +E + Q++ + V+E E+ K+ LDK
Sbjct: 1172 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 389 LQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 447
+Q E++ L +L +++ +E++ ++KL+ + EL+ + +A L +K
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1290
Query: 448 SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 507
+ +E VT + + KA K K+ + Q+ T+ Q
Sbjct: 1291 KLQNEVESVTGML------------------NEAEGKAIKLAKDVASLSSQLQDTQELLQ 1332
Query: 508 EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN------QLKQQEEDFRKQLED--- 558
E R L++ TK E E + +++ QN L Q D +K+L+D
Sbjct: 1333 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1392
Query: 559 -----EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 613
EEG+K + LT++ + Y++L Q +LD V+ L+
Sbjct: 1393 TVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD----LDNQR 1447
Query: 614 AAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQLKSEVSKLRCQ---LAKKKQS 669
L K + + +LL + N+ K DE + ++E + + LA+ +
Sbjct: 1448 QLVSNLEKKQRKFDQLLAEEKNISS------KYADERDRAEAEAREKETKALSLARALEE 1501
Query: 670 ETKLQEEL---NKVLGIK-------HFDPSKAFHHESKENFALKTPLKEGNTNCYRAPME 719
+ +EEL NK+L + D K H K AL+T ++E T E
Sbjct: 1502 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 720 CQ 721
Q
Sbjct: 1562 LQ 1563
Score = 110 bits (275), Expect = 5e-24
Identities = 137/658 (20%), Positives = 292/658 (44%), Gaps = 50/658 (7%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKS------SESKKESQKNDKDLKILEKEIR 93
K ++ +++ S N+ ++ + K+K+ SE + +K +K + LEK R
Sbjct: 1006 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1065
Query: 94 VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 153
L + +I DL+ ++ +++ +L +++ L A A L+ E+ + N LK
Sbjct: 1066 KLEGDASDFHEQIADLQAQIAELKMQL---AKKEEELQAALARLDD---EIAQKNNALKK 1119
Query: 154 KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
G+ +L+ RNK E + R + + E ++ +L+ T S Q A+
Sbjct: 1120 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1179
Query: 214 EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
E + V++ K+ +DE++ + + QV++ + AQ E L E+ ++ K
Sbjct: 1180 EQE-VTVLKKALDEETRSHEA------------QVQEMRQKHAQAVEELTEQLEQFKRAK 1226
Query: 274 QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
+L++N L K+ DL + ++L + K++ ++ ++ L A++Q L+ K ++ R
Sbjct: 1227 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK----LEAQVQELQSKCSDGERAR 1282
Query: 334 -------EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 386
KLQ + + +L + + + L + + S ++ + L +EE +Q L+
Sbjct: 1283 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1342
Query: 387 DKLQQKEEQAERLVKQLEE--EAKSRAEE----LKLLEEKLKGKEAELEKSSAAHTQATL 440
KL+Q EE+ L QL+E EAK E L + K K + + A +
Sbjct: 1343 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1402
Query: 441 LLQEKYDSMVQSLEDVTAQF---ESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH 497
Q++ +++ Q E+ A + E K E++DL ++ + ++ + K
Sbjct: 1403 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1462
Query: 498 QILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 557
+ ++ + +Y + ++ KET+ + + L++ + + +L++ + + ++E
Sbjct: 1463 LLAEEKNISSKYADERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKMLKAEME 1521
Query: 558 DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
D K + EL + EE+ + + + +L A E K L A +
Sbjct: 1522 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1581
Query: 618 QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
Q RD A+ QN +++ + +L + ++L+ E + A KK+ E L++
Sbjct: 1582 QFE--RDLQAR--DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1635
Score = 105 bits (263), Expect = 1e-22
Identities = 139/662 (20%), Positives = 294/662 (44%), Gaps = 94/662 (14%)
Query: 47 QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKI-----LEKEIRVLLQERGA 101
Q+E++Q LNV + K++ E ++ S ++ D ++ LE+ I L +
Sbjct: 1332 QEETRQKLNV---------STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 102 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN--- 158
+++QD + +E +E +E +L+ +L +T L+ + +
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 159 -GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 217
NQ+ L + +LE K++ K ++A+++ + K +R E++ + + E K
Sbjct: 1443 LDNQRQL-VSNLE------KKQRKFDQLLAEEKNISSKY-ADERDRAEAEAR--EKETKA 1492
Query: 218 VSIEK---EKIDEKSETEK----LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 270
+S+ + E ++ K E E+ L +E++ + D V K ++ + + L+ + +E+
Sbjct: 1493 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1552
Query: 271 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
+ + LE+ + L V Q L+ + E + E NE ++Q ++ E
Sbjct: 1553 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1612
Query: 331 QEREKLQ------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 384
++ K + +K+L+ D L E + S++ + EE +K+ + ++K
Sbjct: 1613 EDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGR-----EEAIKQLRKLQAQMKDFQR 1666
Query: 385 ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG-----KEAELEKSSAAHTQAT 439
EL+ + ++ K+ E++AKS +L L+E L K+A+LEK A A+
Sbjct: 1667 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1726
Query: 440 LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
L S +L+D + E+ A E+E+ + ++ ++ KA + AE + ++
Sbjct: 1727 SL------SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE- 1779
Query: 500 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
LATE S QK + QL++Q ++ R +L +
Sbjct: 1780 LATERST----------------------------AQKNESARQQLERQNKELRSKLHEM 1811
Query: 560 EGR-KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 618
EG K++ ++T A L +I + L E++ + + Q + + +K L E E
Sbjct: 1812 EGAVKSKFKSTIAALEAKIAQ---LEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVED 1867
Query: 619 LNKIRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676
K+ + Y + G+ +KQ + + + ++E+ ++ + KL+ +L + +S + E
Sbjct: 1868 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1927
Query: 677 LN 678
+N
Sbjct: 1928 VN 1929
Score = 86.3 bits (212), Expect = 9e-17
Identities = 119/536 (22%), Positives = 249/536 (46%), Gaps = 54/536 (10%)
Query: 172 MKLRN----KRETKMRGMMA---KQEGMEMK---LQVTQRSLEESQGKIAQLEGKLVSIE 221
+KLRN + TK++ ++ ++E M+ K LQ T+ ++++ ++ +LE K +
Sbjct: 834 LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT 893
Query: 222 KEK--IDE--KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND---EILSLKQ 274
+EK + E ++ETE E E + + ++ + + ++E L+E+ D ++ + ++
Sbjct: 894 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 953
Query: 275 SLEENIVILSKQVEDLNVKCQLLEKEK-EDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
+ + ++ L +Q+E+ Q L+ EK + +E L + QN K +ER
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-----SKER 1008
Query: 334 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK- 392
+ L+++ + + L +E+E + +L KL + E M+ E + ++ +++ EL+KL++K
Sbjct: 1009 KLLEERISDLTTNLAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1067
Query: 393 EEQAERLVKQLEEEAKSRAE---ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 449
E A +Q+ + AE +L EE+L+ A L+ A A ++E +
Sbjct: 1068 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 450 VQSLEDVTAQ------FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
ED+ ++ E K E+E LK E + A Q ++ A
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA--------TQQELRAKR 1179
Query: 504 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
++ LD +T+S E +++E+ Q + +L QL+Q F++ + + K
Sbjct: 1180 EQEVTVLKKALDEETRS--HEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNK 1233
Query: 564 AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ--EQLNK 621
E A+L E+ +E+ +K K + Q+ E++ + E A+ ++++K
Sbjct: 1234 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHK 1291
Query: 622 IRDSYAKLLGHQNLKQ--KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
+++ + G N + IK + +SQL+ L+ + +K TKL++
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347
Score = 83.2 bits (204), Expect = 8e-16
Identities = 105/509 (20%), Positives = 216/509 (42%), Gaps = 75/509 (14%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
S ++ +++ + +K+T + AR ++ + E+K+E ++ +K LK +
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1530
Query: 89 EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
K + L + + A + ++++++T+LE++E L A K L N L+ Q
Sbjct: 1531 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF------E 1584
Query: 149 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA----KQEG----MEMKLQVTQ 200
L+++ +N ++ L + + E K R + A K EG +E++
Sbjct: 1585 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1644
Query: 201 RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 260
+ EE+ ++ +L+ ++ ++E D ++ +++ +E + +E D+ QL+E
Sbjct: 1645 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQE 1701
Query: 261 NL-------KEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEKEDHVNRNRE 310
+L K+ + E L + L ++ L + L + LE+E E+
Sbjct: 1702 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1761
Query: 311 HNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
++ + Q +Q ER Q+ E L +Q KEL S LH+ E VK
Sbjct: 1762 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE-----MEGAVK 1816
Query: 371 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 430
K K T+ L E + QLEE+ + A E + + LK K+ +L++
Sbjct: 1817 SK------FKSTIAAL----------EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 431 SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGK 490
+LLQ V+ + Q++ + ++ LK + +E++ +
Sbjct: 1861 ---------ILLQ------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1905
Query: 491 NAEDVQHQILATESSNQEYVRMLLDLQTK 519
N +Q ++ SN+ R + L++K
Sbjct: 1906 NRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 80.1 bits (196), Expect = 7e-15
Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 32/336 (9%)
Query: 376 EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
EEE++ DEL K ++++++AE +K+LE++ EE LL+E+L +AE E + A
Sbjct: 858 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAE 914
Query: 436 TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 495
L +K Q LE++ + E + +E+ + LQ + K + D+
Sbjct: 915 EMRVRLAAKK-----QELEEILHEME-------ARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 496 QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ 555
+ Q+ E++ Q+ LQ + E +IK++ L + D N+L ++ + ++
Sbjct: 963 EEQLEEEEAARQK-------LQLEKVTAEAKIKKLEDEIL-VMDDQNNKLSKERKLLEER 1014
Query: 556 LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAA 615
+ D AE+E LT+ NK + EL + K + E K+ L +
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074
Query: 616 QEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE---TK 672
EQ+ ++ A+L Q K +L+ ++L E+++ L K ++ E +
Sbjct: 1075 HEQIADLQAQIAEL-----KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 673 LQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
LQE+L+ ++ K +E ALKT L++
Sbjct: 1130 LQEDLDSERAARN-KAEKQKRDLGEELEALKTELED 1164
Score = 76.3 bits (186), Expect = 1e-13
Identities = 93/420 (22%), Positives = 192/420 (45%), Gaps = 50/420 (11%)
Query: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
KED + + +E + E++ L+QK + E + L Q++LQ ++ L E E + +
Sbjct: 864 KEDELQKTKERQQKAENELKELEQKHS-QLTEEKNLLQEQLQAETELYAEAE---EMRVR 919
Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQ-QKEEQAERLV---KQLEEEAKSRAEELKL 416
L + ++E+ + + E L++ D +LQ ++++ A++++ +QLEEE +R ++L+L
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQL 978
Query: 417 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF--ESYKALTASEIEDL 474
+ + K +LE L ++ + + + D+T E KA +++++
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN- 1037
Query: 475 KLEN--SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT-------KSALKET 525
K E+ S L+ + K K+ ++++ E ++ + DLQ + A KE
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097
Query: 526 EIKEITVSFLQKITDLQNQLKQQEE------DFRKQLEDEEGRKAEKENTTAELTEEINK 579
E++ +I N LK+ E D ++ L+ E + + E +L EE+
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157
Query: 580 WRLLYEELYNKTKPFQLQLDA-----FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 634
+ E+ + T Q +L A V K+AL E + + Q+ ++R +A+ + +
Sbjct: 1158 LKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV--EE 1214
Query: 635 LKQKIKHVVKLKDENSQLKSEVSKLRCQLA---------------KKKQSETKLQEELNK 679
L ++++ + K + K + K LA KKK+ E ++QE +K
Sbjct: 1215 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1274
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 113 bits (283), Expect = 5e-25
Identities = 154/722 (21%), Positives = 309/722 (42%), Gaps = 89/722 (12%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSSESKKESQK--NDKDLKILEKEIR--VLL 96
SQ +++ ++ L + + A +V+ + K+E ++ ++ + ++ E+E R L
Sbjct: 883 SQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQ 942
Query: 97 QERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLI-------ELTRTNE 149
ER +++ DLE +LE+ EA EK + A LE +++ +L++ +
Sbjct: 943 AERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 150 LLKSKFSE-NGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQG 208
LL+ + S+ N + L KL+NK E+ + +E++L+ ++S +E +
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMI-------SELEVRLKKEEKSRQELEK 1055
Query: 209 KIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDE 268
+LEG ++ D +++ +L + + + E+ + +A+L++ + +KN+
Sbjct: 1056 LKRKLEGDASDFHEQIADLQAQIAELKMQL------AKKEEELQAALARLDDEIAQKNNA 1109
Query: 269 ILSLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFIL 328
+ +++ LE +I L + ++ EK+K D E E L E+++
Sbjct: 1110 LKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRD----LGEELEALKTELEDTLDSTAT 1164
Query: 329 EQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDK 388
+Q+ R K +Q+ + L +E + Q++ + V+E E+ K+ LDK
Sbjct: 1165 QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 389 LQQK-EEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYD 447
+Q E++ L +L +++ +E++ ++KL+ + EL+ + +A L +K
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAK-QEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVH 1283
Query: 448 SMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQ 507
+ +E VT + + KA K K+ + Q+ T+ Q
Sbjct: 1284 KLQNEVESVTGML------------------NEAEGKAIKLAKDVASLSSQLQDTQELLQ 1325
Query: 508 EYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQN------QLKQQEEDFRKQLED--- 558
E R L++ TK E E + +++ QN L Q D +K+L+D
Sbjct: 1326 EETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFAS 1385
Query: 559 -----EEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHG 613
EEG+K + LT++ + Y++L Q +LD V+ L+
Sbjct: 1386 TVEALEEGKK-RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD----LDNQR 1440
Query: 614 AAQEQLNKIRDSYAKLLGHQ-NLKQKIKHVVKLKDENSQLKSEVSKLRCQ---LAKKKQS 669
L K + + +LL + N+ K DE + ++E + + LA+ +
Sbjct: 1441 QLVSNLEKKQRKFDQLLAEEKNISS------KYADERDRAEAEAREKETKALSLARALEE 1494
Query: 670 ETKLQEEL---NKVLGIK-------HFDPSKAFHHESKENFALKTPLKEGNTNCYRAPME 719
+ +EEL NK+L + D K H K AL+T ++E T E
Sbjct: 1495 ALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 720 CQ 721
Q
Sbjct: 1555 LQ 1556
Score = 110 bits (275), Expect = 5e-24
Identities = 137/658 (20%), Positives = 292/658 (44%), Gaps = 50/658 (7%)
Query: 40 KSQRFKQQKESKQNLNVDKDTTLPASARKVKS------SESKKESQKNDKDLKILEKEIR 93
K ++ +++ S N+ ++ + K+K+ SE + +K +K + LEK R
Sbjct: 999 KERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKR 1058
Query: 94 VLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKS 153
L + +I DL+ ++ +++ +L +++ L A A L+ E+ + N LK
Sbjct: 1059 KLEGDASDFHEQIADLQAQIAELKMQL---AKKEEELQAALARLDD---EIAQKNNALKK 1112
Query: 154 KFSENGNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQL 213
G+ +L+ RNK E + R + + E ++ +L+ T S Q A+
Sbjct: 1113 IRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKR 1172
Query: 214 EGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEILSLK 273
E + V++ K+ +DE++ + + QV++ + AQ E L E+ ++ K
Sbjct: 1173 EQE-VTVLKKALDEETRSHEA------------QVQEMRQKHAQAVEELTEQLEQFKRAK 1219
Query: 274 QSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
+L++N L K+ DL + ++L + K++ ++ ++ L A++Q L+ K ++ R
Sbjct: 1220 ANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK----LEAQVQELQSKCSDGERAR 1275
Query: 334 -------EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDEL 386
KLQ + + +L + + + L + + S ++ + L +EE +Q L+
Sbjct: 1276 AELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVS 1335
Query: 387 DKLQQKEEQAERLVKQLEE--EAKSRAEE----LKLLEEKLKGKEAELEKSSAAHTQATL 440
KL+Q EE+ L QL+E EAK E L + K K + + A +
Sbjct: 1336 TKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKK 1395
Query: 441 LLQEKYDSMVQSLEDVTAQF---ESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQH 497
Q++ +++ Q E+ A + E K E++DL ++ + ++ + K
Sbjct: 1396 RFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQ 1455
Query: 498 QILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLE 557
+ ++ + +Y + ++ KET+ + + L++ + + +L++ + + ++E
Sbjct: 1456 LLAEEKNISSKYADERDRAEAEAREKETKALSLARA-LEEALEAKEELERTNKMLKAEME 1514
Query: 558 DEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQE 617
D K + EL + EE+ + + + +L A E K L A +
Sbjct: 1515 DLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKG 1574
Query: 618 QLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
Q RD A+ QN +++ + +L + ++L+ E + A KK+ E L++
Sbjct: 1575 QFE--RDLQAR--DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKD 1628
Score = 105 bits (263), Expect = 1e-22
Identities = 139/662 (20%), Positives = 294/662 (44%), Gaps = 94/662 (14%)
Query: 47 QKESKQNLNVDKDTTLPASARKVKSSESKKESQKNDKDLKI-----LEKEIRVLLQERGA 101
Q+E++Q LNV + K++ E ++ S ++ D ++ LE+ I L +
Sbjct: 1325 QEETRQKLNV---------STKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 102 QDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTNELLKSKFSEN--- 158
+++QD + +E +E +E +L+ +L +T L+ + +
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 159 -GNQKNLRILSLELMKLRNKRETKMRGMMAKQEGMEMKLQVTQRSLEESQGKIAQLEGKL 217
NQ+ L + +LE K++ K ++A+++ + K +R E++ + + E K
Sbjct: 1436 LDNQRQL-VSNLE------KKQRKFDQLLAEEKNISSKY-ADERDRAEAEAR--EKETKA 1485
Query: 218 VSIEK---EKIDEKSETEK----LLEYIEEISCASDQVEKYKLDIAQLEENLKEKNDEIL 270
+S+ + E ++ K E E+ L +E++ + D V K ++ + + L+ + +E+
Sbjct: 1486 LSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMK 1545
Query: 271 SLKQSLEENIVILSKQVEDLNVKCQLLEKEKEDHVNRNREHNENLNAEMQNLKQKFILEQ 330
+ + LE+ + L V Q L+ + E + E NE ++Q ++ E
Sbjct: 1546 TQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETEL 1605
Query: 331 QEREKLQ------QKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLD 384
++ K + +K+L+ D L E + S++ + EE +K+ + ++K
Sbjct: 1606 EDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGR-----EEAIKQLRKLQAQMKDFQR 1659
Query: 385 ELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKG-----KEAELEKSSAAHTQAT 439
EL+ + ++ K+ E++AKS +L L+E L K+A+LEK A A+
Sbjct: 1660 ELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS 1719
Query: 440 LLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQI 499
L S +L+D + E+ A E+E+ + ++ ++ KA + AE + ++
Sbjct: 1720 SL------SGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNE- 1772
Query: 500 LATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDE 559
LATE S QK + QL++Q ++ R +L +
Sbjct: 1773 LATERST----------------------------AQKNESARQQLERQNKELRSKLHEM 1804
Query: 560 EGR-KAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQEQ 618
EG K++ ++T A L +I + L E++ + + Q + + +K L E E
Sbjct: 1805 EGAVKSKFKSTIAALEAKIAQ---LEEQVEQEAREKQAATKSLK-QKDKKLKEILLQVED 1860
Query: 619 LNKIRDSYAKLL--GHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQEE 676
K+ + Y + G+ +KQ + + + ++E+ ++ + KL+ +L + +S + E
Sbjct: 1861 ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGRE 1920
Query: 677 LN 678
+N
Sbjct: 1921 VN 1922
Score = 86.3 bits (212), Expect = 9e-17
Identities = 119/536 (22%), Positives = 249/536 (46%), Gaps = 54/536 (10%)
Query: 172 MKLRN----KRETKMRGMMA---KQEGMEMK---LQVTQRSLEESQGKIAQLEGKLVSIE 221
+KLRN + TK++ ++ ++E M+ K LQ T+ ++++ ++ +LE K +
Sbjct: 827 LKLRNWQWWRLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT 886
Query: 222 KEK--IDE--KSETEKLLEYIEEISCASDQVEKYKLDIAQLEENLKEKND---EILSLKQ 274
+EK + E ++ETE E E + + ++ + + ++E L+E+ D ++ + ++
Sbjct: 887 EEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK 946
Query: 275 SLEENIVILSKQVEDLNVKCQLLEKEK-EDHVNRNREHNENLNAEMQNLKQKFILEQQER 333
+ + ++ L +Q+E+ Q L+ EK + +E L + QN K +ER
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKL-----SKER 1001
Query: 334 EKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVKEKNLFEEELKQTLDELDKLQQK- 392
+ L+++ + + L +E+E + +L KL + E M+ E + ++ +++ EL+KL++K
Sbjct: 1002 KLLEERISDLTTNLAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL 1060
Query: 393 EEQAERLVKQLEEEAKSRAE---ELKLLEEKLKGKEAELEKSSAAHTQATLLLQEKYDSM 449
E A +Q+ + AE +L EE+L+ A L+ A A ++E +
Sbjct: 1061 EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 450 VQSLEDVTAQ------FESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDVQHQILATE 503
ED+ ++ E K E+E LK E + A Q ++ A
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTA--------TQQELRAKR 1172
Query: 504 SSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQLEDEEGRK 563
++ LD +T+S E +++E+ Q + +L QL+Q F++ + + K
Sbjct: 1173 EQEVTVLKKALDEETRS--HEAQVQEMRQKHAQAVEELTEQLEQ----FKRAKANLDKNK 1226
Query: 564 AEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAAQ--EQLNK 621
E A+L E+ +E+ +K K + Q+ E++ + E A+ ++++K
Sbjct: 1227 QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQ--ELQSKCSDGERARAELNDKVHK 1284
Query: 622 IRDSYAKLLGHQNLKQ--KIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSETKLQE 675
+++ + G N + IK + +SQL+ L+ + +K TKL++
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340
Score = 83.2 bits (204), Expect = 8e-16
Identities = 105/509 (20%), Positives = 216/509 (42%), Gaps = 75/509 (14%)
Query: 41 SQRFKQQKESKQNLNVDKDTTLPASARKVKSS-ESKKESQKNDKDLKI-----------L 88
S ++ +++ + +K+T + AR ++ + E+K+E ++ +K LK +
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV 1523
Query: 89 EKEIRVLLQERGAQDRRIQDLETELEKMEARLNAALREKTSLSANNATLEKQLIELTRTN 148
K + L + + A + ++++++T+LE++E L A K L N L+ Q
Sbjct: 1524 GKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF------E 1577
Query: 149 ELLKSKFSENGNQKNLRILSLELMKLRNKRETKMRGMMA----KQEG----MEMKLQVTQ 200
L+++ +N ++ L + + E K R + A K EG +E++
Sbjct: 1578 RDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAI 1637
Query: 201 RSLEESQGKIAQLEGKLVSIEKEKIDEKSETEKLLEYIEEISCASDQVEKYKLDIAQLEE 260
+ EE+ ++ +L+ ++ ++E D ++ +++ +E + +E D+ QL+E
Sbjct: 1638 KGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEA---DLMQLQE 1694
Query: 261 NL-------KEKNDEILSLKQSLEENIV---ILSKQVEDLNVKCQLLEKEKEDHVNRNRE 310
+L K+ + E L + L ++ L + L + LE+E E+
Sbjct: 1695 DLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEA 1754
Query: 311 HNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQKLCSFQEEMVK 370
++ + Q +Q ER Q+ E L +Q KEL S LH+ E VK
Sbjct: 1755 MSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHE-----MEGAVK 1809
Query: 371 EKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEK 430
K K T+ L E + QLEE+ + A E + + LK K+ +L++
Sbjct: 1810 SK------FKSTIAAL----------EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 431 SSAAHTQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGK 490
+LLQ V+ + Q++ + ++ LK + +E++ +
Sbjct: 1854 ---------ILLQ------VEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINA 1898
Query: 491 NAEDVQHQILATESSNQEYVRMLLDLQTK 519
N +Q ++ SN+ R + L++K
Sbjct: 1899 NRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 80.1 bits (196), Expect = 7e-15
Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 32/336 (9%)
Query: 376 EEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAEELKLLEEKLKGKEAELEKSSAAH 435
EEE++ DEL K ++++++AE +K+LE++ EE LL+E+L +AE E + A
Sbjct: 851 EEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQL---QAETELYAEAE 907
Query: 436 TQATLLLQEKYDSMVQSLEDVTAQFESYKALTASEIEDLKLENSSLQEKAAKAGKNAEDV 495
L +K Q LE++ + E + +E+ + LQ + K + D+
Sbjct: 908 EMRVRLAAKK-----QELEEILHEME-------ARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 496 QHQILATESSNQEYVRMLLDLQTKSALKETEIKEITVSFLQKITDLQNQLKQQEEDFRKQ 555
+ Q+ E++ Q+ LQ + E +IK++ L + D N+L ++ + ++
Sbjct: 956 EEQLEEEEAARQK-------LQLEKVTAEAKIKKLEDEIL-VMDDQNNKLSKERKLLEER 1007
Query: 556 LEDEEGRKAEKENTTAELTEEINKWRLLYEELYNKTKPFQLQLDAFEVEKQALLNEHGAA 615
+ D AE+E LT+ NK + EL + K + E K+ L +
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067
Query: 616 QEQLNKIRDSYAKLLGHQNLKQKIKHVVKLKDENSQLKSEVSKLRCQLAKKKQSE---TK 672
EQ+ ++ A+L Q K +L+ ++L E+++ L K ++ E +
Sbjct: 1068 HEQIADLQAQIAEL-----KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 673 LQEELNKVLGIKHFDPSKAFHHESKENFALKTPLKE 708
LQE+L+ ++ K +E ALKT L++
Sbjct: 1123 LQEDLDSERAARN-KAEKQKRDLGEELEALKTELED 1157
Score = 76.3 bits (186), Expect = 1e-13
Identities = 93/420 (22%), Positives = 192/420 (45%), Gaps = 50/420 (11%)
Query: 301 KEDHVNRNREHNENLNAEMQNLKQKFILEQQEREKLQQKELQIDSLLQQEKELSSSLHQK 360
KED + + +E + E++ L+QK + E + L Q++LQ ++ L E E + +
Sbjct: 857 KEDELQKTKERQQKAENELKELEQKHS-QLTEEKNLLQEQLQAETELYAEAE---EMRVR 912
Query: 361 LCSFQEEMVKEKNLFEEELKQTLDELDKLQ-QKEEQAERLV---KQLEEEAKSRAEELKL 416
L + ++E+ + + E L++ D +LQ ++++ A++++ +QLEEE +R ++L+L
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAAR-QKLQL 971
Query: 417 LEEKLKGKEAELEKSSAAHTQATLLLQEKYDSMVQSLEDVTAQF--ESYKALTASEIEDL 474
+ + K +LE L ++ + + + D+T E KA +++++
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKN- 1030
Query: 475 KLEN--SSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQT-------KSALKET 525
K E+ S L+ + K K+ ++++ E ++ + DLQ + A KE
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090
Query: 526 EIKEITVSFLQKITDLQNQLKQQEE------DFRKQLEDEEGRKAEKENTTAELTEEINK 579
E++ +I N LK+ E D ++ L+ E + + E +L EE+
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150
Query: 580 WRLLYEELYNKTKPFQLQLDA-----FEVEKQALLNEHGAAQEQLNKIRDSYAKLLGHQN 634
+ E+ + T Q +L A V K+AL E + + Q+ ++R +A+ + +
Sbjct: 1151 LKTELEDTLDSTAT-QQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAV--EE 1207
Query: 635 LKQKIKHVVKLKDENSQLKSEVSKLRCQLA---------------KKKQSETKLQEELNK 679
L ++++ + K + K + K LA KKK+ E ++QE +K
Sbjct: 1208 LTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSK 1267
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.124 0.315
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,266,007
Number of Sequences: 37866
Number of extensions: 1167960
Number of successful extensions: 29776
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 697
Number of HSP's successfully gapped in prelim test: 1409
Number of HSP's that attempted gapping in prelim test: 7207
Number of HSP's gapped (non-prelim): 8367
length of query: 725
length of database: 18,247,518
effective HSP length: 110
effective length of query: 615
effective length of database: 14,082,258
effective search space: 8660588670
effective search space used: 8660588670
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.