Search of human proteins with 21541824

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]
         (770 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]        1582   0.0  
gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]        1363   0.0  
gi|157384982 transducin-like enhancer protein 3 isoform a [Homo ...  1247   0.0  
gi|157384986 transducin-like enhancer protein 3 isoform b [Homo ...  1246   0.0  
gi|157384984 transducin-like enhancer protein 3 isoform c [Homo ...  1230   0.0  
gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo s...   986   0.0  
gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo ...   861   0.0  
gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo ...   808   0.0  
gi|5706731 amino-terminal enhancer of split isoform b [Homo sapi...   241   2e-63
gi|39812027 amino-terminal enhancer of split isoform c [Homo sap...   239   9e-63
gi|39812019 amino-terminal enhancer of split isoform a [Homo sap...   233   5e-61
gi|221136834 transducin-like enhancer of split 6 isoform 1 [Homo...   198   2e-50
gi|13376099 transducin-like enhancer of split 6 isoform 2 [Homo ...   198   2e-50
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]             89   2e-17
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             89   2e-17
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             89   2e-17
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is...    88   3e-17
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i...    88   3e-17
gi|26665869 WD repeat domain 51B [Homo sapiens]                        86   2e-16
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    84   4e-16
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi...    73   1e-12
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H...    70   1e-11
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...    69   1e-11
gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo ...    69   1e-11
gi|8923881 WD SOCS-box protein 2 [Homo sapiens]                        69   2e-11
gi|5174447 guanine nucleotide binding protein (G protein), beta ...    68   3e-11
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                     67   5e-11
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     67   5e-11
gi|13376840 WD repeat domain 61 [Homo sapiens]                         66   1e-10
gi|16554629 WD repeat domain 5 [Homo sapiens]                          65   2e-10

>gi|21541824 transducin-like enhancer protein 1 [Homo sapiens]
          Length = 770

 Score = 1582 bits (4097), Expect = 0.0
 Identities = 770/770 (100%), Positives = 770/770 (100%)

Query: 1   MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60
           MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH
Sbjct: 1   MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN 120
           YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN 120

Query: 121 AIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIK 180
           AIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIK
Sbjct: 121 AIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIK 180

Query: 181 DDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSD 240
           DDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSD
Sbjct: 181 DDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSD 240

Query: 241 GDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASSTSLK 300
           GDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASSTSLK
Sbjct: 241 GDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASSTSLK 300

Query: 301 SKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRT 360
           SKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRT
Sbjct: 301 SKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRT 360

Query: 361 PLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSPMVG 420
           PLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSPMVG
Sbjct: 361 PLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSPMVG 420

Query: 421 FDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINT 480
           FDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINT
Sbjct: 421 FDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINT 480

Query: 481 LNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP 540
           LNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP
Sbjct: 481 LNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLP 540

Query: 541 DGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAV 600
           DGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAV
Sbjct: 541 DGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAV 600

Query: 601 WDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQI 660
           WDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQI
Sbjct: 601 WDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQI 660

Query: 661 FSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDN 720
           FSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDN
Sbjct: 661 FSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDN 720

Query: 721 LLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 770
           LLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
Sbjct: 721 LLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 770


>gi|34915994 transducin-like enhancer protein 4 [Homo sapiens]
          Length = 773

 Score = 1363 bits (3529), Expect = 0.0
 Identities = 668/772 (86%), Positives = 710/772 (91%), Gaps = 8/772 (1%)

Query: 1   MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60
           M+PQ+RHP PHQ A QPFKFTI ES DRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH
Sbjct: 8   MYPQTRHPAPHQPA-QPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 66

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN 120
           YVMYYEMSYGLNIEMHKQ EI KRLN ICAQVIPFLSQEHQQQV QAVERAKQVTMAELN
Sbjct: 67  YVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELN 126

Query: 121 AIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIK 180
           AIIGQQ LQAQHLSHGHG PVPLTPHPSGLQPP IPP+G SAGLLALSSAL GQSHL IK
Sbjct: 127 AIIGQQ-LQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIK 185

Query: 181 DDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKD-SSHYDS 239
           D+KKHHD +H RDR+   S+S+    S RG +K RN  ++S++ KK+K ++K+ ++ YDS
Sbjct: 186 DEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDS 245

Query: 240 DGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASSTSL 299
           DG+KSDDNLVVDVSNEDPSSPR SPAHSPRENG+DK RLLKKDA  SPAS ASS+S+ S 
Sbjct: 246 DGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASIASSSSTPSS 305

Query: 300 KSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLR 359
           KSKE+SL+EK++TPV KS+TPTPR+D PTPG+++TPGLRP  GKPP +DPL    A+ LR
Sbjct: 306 KSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPL----ASSLR 361

Query: 360 TPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVA-YGRSPM 418
           TP+AVP PYP PFG+VPHAGMNGELTSPGAAYA LHN+SPQMSAAAAAAA  A YGRSP+
Sbjct: 362 TPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPV 421

Query: 419 VGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQI 478
           VGFDP  HMRVP IPPNL GIPGGKPAYSFHV+ADGQMQPVPFPPDALIGPGIPRHARQI
Sbjct: 422 VGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQI 481

Query: 479 NTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKL 538
           NTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSC+L
Sbjct: 482 NTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRL 541

Query: 539 LPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNI 598
           LPDG TLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNI
Sbjct: 542 LPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNI 601

Query: 599 AVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTS 658
           AVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTS
Sbjct: 602 AVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTS 661

Query: 659 QIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGK 718
           QIFSLGYCPTGEWLAVGME+SNVEVLHV KPDKYQLHLHESCVLSLKFA+CGKWFVSTGK
Sbjct: 662 QIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGK 721

Query: 719 DNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 770
           DNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
Sbjct: 722 DNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 773


>gi|157384982 transducin-like enhancer protein 3 isoform a [Homo
           sapiens]
          Length = 772

 Score = 1247 bits (3226), Expect = 0.0
 Identities = 622/778 (79%), Positives = 681/778 (87%), Gaps = 14/778 (1%)

Query: 1   MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60
           M+PQ RHP PHQ     FKFT+ ES DRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRH
Sbjct: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN 120
           YVMYYEMSYGLNIEMHKQTEIAKRLNTI AQ++PFLSQEHQQQVAQAVERAKQVTM ELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120

Query: 121 AIIGQQQLQAQHLSHG-HGPPVPLTPHPSGLQPPGIPPL-GGSAGLLALSSALSGQSHLA 178
           AIIGQQQLQAQHLSH  HGPPV L PHPSGLQPPGIPP+ G S+GLLAL  AL  Q+HL 
Sbjct: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALG-ALGSQAHLT 179

Query: 179 IKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDS-SHY 237
           +KD+K HH+ +H R+RE   +NS+   +SLR ++K R   ++S + KKRK ++KDS S Y
Sbjct: 180 VKDEKNHHELDH-RERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRY 238

Query: 238 DSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASST 297
           DSDGDKSDD LVVDVSNEDP++PR SPAHSP ENG+DK R LKKDA +SPAS ASS+S+ 
Sbjct: 239 DSDGDKSDD-LVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTP 297

Query: 298 SLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAG 357
           S K+K++  ++K+STP LKS+TPTPR+D PTPGTS TPGLR   GKPP +DP+   A+A 
Sbjct: 298 SSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPIGIMASA- 356

Query: 358 LRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSP 417
           LRTP+++   Y APF M+ H  MNG LTSPGA YA LHN+ PQMSAAAAAAA  AYGRSP
Sbjct: 357 LRTPISITSSYAAPFAMMSHHEMNGSLTSPGA-YAGLHNIPPQMSAAAAAAAA-AYGRSP 414

Query: 418 MV-----GFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIP 472
           MV     GFDP P MR   +P +LA IPGGKPAYSFHV+ADGQMQPVPFP DAL GPGIP
Sbjct: 415 MVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIP 474

Query: 473 RHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNY 532
           RHARQINTL+HGEVVCAVTISNPTRHVYTGGKGCVK+WDIS PG+KSP+SQLDCLNRDNY
Sbjct: 475 RHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNY 534

Query: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592
           IRSCKLLPDG TLIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALAISPD+KVCFSC
Sbjct: 535 IRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSC 594

Query: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
           CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDIS+DGTKLWTGGLDNTVRSWDLREGRQLQ
Sbjct: 595 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 654

Query: 653 QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKW 712
           QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH  KPDKYQLHLHESCVLSLKFAYCGKW
Sbjct: 655 QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKW 714

Query: 713 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 770
           FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS DDKYIVTGSGDKKATVYEVIY
Sbjct: 715 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 772


>gi|157384986 transducin-like enhancer protein 3 isoform b [Homo
           sapiens]
          Length = 769

 Score = 1246 bits (3225), Expect = 0.0
 Identities = 621/778 (79%), Positives = 680/778 (87%), Gaps = 17/778 (2%)

Query: 1   MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60
           M+PQ RHP PHQ     FKFT+ ES DRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRH
Sbjct: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN 120
           YVMYYEMSYGLNIEMHKQTEIAKRLNTI AQ++PFLSQEHQQQVAQAVERAKQVTM ELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120

Query: 121 AIIGQQQLQAQHLSHG-HGPPVPLTPHPSGLQPPGIPPL-GGSAGLLALSSALSGQSHLA 178
           AIIGQQQLQAQHLSH  HGPPV L PHPSGLQPPGIPP+ G S+GLLAL  AL  Q+HL 
Sbjct: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALG-ALGSQAHLT 179

Query: 179 IKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDS-SHY 237
           +KD+K HH+ +H R+RE   +NS+   +SLR ++K R   ++S + KKRK ++KDS S Y
Sbjct: 180 VKDEKNHHELDH-RERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRY 238

Query: 238 DSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASST 297
           DSDGDKSDD LVVDVSNEDP++PR SPAHSP ENG+DK R LKKDA +SPAS ASS+S+ 
Sbjct: 239 DSDGDKSDD-LVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTP 297

Query: 298 SLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAG 357
           S K+K++  ++K+STP LKS+TPTPR+D PTPGTS TPGLR   GKPP +DP+    A+ 
Sbjct: 298 SSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPI----ASA 353

Query: 358 LRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSP 417
           LRTP+++   Y APF M+ H  MNG LTSPGA YA LHN+ PQMSAAAAAAA  AYGRSP
Sbjct: 354 LRTPISITSSYAAPFAMMSHHEMNGSLTSPGA-YAGLHNIPPQMSAAAAAAAA-AYGRSP 411

Query: 418 MV-----GFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIP 472
           MV     GFDP P MR   +P +LA IPGGKPAYSFHV+ADGQMQPVPFP DAL GPGIP
Sbjct: 412 MVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIP 471

Query: 473 RHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNY 532
           RHARQINTL+HGEVVCAVTISNPTRHVYTGGKGCVK+WDIS PG+KSP+SQLDCLNRDNY
Sbjct: 472 RHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNY 531

Query: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592
           IRSCKLLPDG TLIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALAISPD+KVCFSC
Sbjct: 532 IRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSC 591

Query: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
           CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDIS+DGTKLWTGGLDNTVRSWDLREGRQLQ
Sbjct: 592 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 651

Query: 653 QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKW 712
           QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH  KPDKYQLHLHESCVLSLKFAYCGKW
Sbjct: 652 QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKW 711

Query: 713 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 770
           FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS DDKYIVTGSGDKKATVYEVIY
Sbjct: 712 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 769


>gi|157384984 transducin-like enhancer protein 3 isoform c [Homo
           sapiens]
          Length = 760

 Score = 1230 bits (3182), Expect = 0.0
 Identities = 615/778 (79%), Positives = 673/778 (86%), Gaps = 26/778 (3%)

Query: 1   MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60
           M+PQ RHP PHQ     FKFT+ ES DRIK+EFQFLQAQYHSLK+E +KLA+EKTEMQRH
Sbjct: 1   MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRH 60

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN 120
           YVMYYEMSYGLNIEMHKQTEIAKRLNTI AQ++PFLSQEHQQQVAQAVERAKQVTM ELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELN 120

Query: 121 AIIGQQQLQAQHLSHG-HGPPVPLTPHPSGLQPPGIPPL-GGSAGLLALSSALSGQSHLA 178
           AIIGQQQLQAQHLSH  HGPPV L PHPSGLQPPGIPP+ G S+GLLAL  AL  Q+HL 
Sbjct: 121 AIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALG-ALGSQAHLT 179

Query: 179 IKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDS-SHY 237
           +KD+K HH+ +H R+RE   +NS+   +SLR ++K R   ++S + KKRK ++KDS S Y
Sbjct: 180 VKDEKNHHELDH-RERESSANNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRY 238

Query: 238 DSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASST 297
           DSDGDKSDD LVVDVSNEDP++PR SPAHSP ENG+DK R LKKDA +SPAS ASS+S+ 
Sbjct: 239 DSDGDKSDD-LVVDVSNEDPATPRVSPAHSPPENGLDKARSLKKDAPTSPASVASSSSTP 297

Query: 298 SLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAG 357
           S K+K++  ++K+STP LKS+TPTPR+D PTPGTS TPGLR             +  A+ 
Sbjct: 298 SSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLR-------------SMPASA 344

Query: 358 LRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSP 417
           LRTP+++   Y APF M+ H  MNG LTSPGA YA LHN+ PQMSAAAAAAA  AYGRSP
Sbjct: 345 LRTPISITSSYAAPFAMMSHHEMNGSLTSPGA-YAGLHNIPPQMSAAAAAAAA-AYGRSP 402

Query: 418 MV-----GFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIP 472
           MV     GFDP P MR   +P +LA IPGGKPAYSFHV+ADGQMQPVPFP DAL GPGIP
Sbjct: 403 MVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIP 462

Query: 473 RHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNY 532
           RHARQINTL+HGEVVCAVTISNPTRHVYTGGKGCVK+WDIS PG+KSP+SQLDCLNRDNY
Sbjct: 463 RHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNY 522

Query: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592
           IRSCKLLPDG TLIVGGEASTL+IWDLA+PTPRIKAELTSSAPACYALAISPD+KVCFSC
Sbjct: 523 IRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSC 582

Query: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
           CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDIS+DGTKLWTGGLDNTVRSWDLREGRQLQ
Sbjct: 583 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQ 642

Query: 653 QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKW 712
           QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH  KPDKYQLHLHESCVLSLKFAYCGKW
Sbjct: 643 QHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKW 702

Query: 713 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 770
           FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS DDKYIVTGSGDKKATVYEVIY
Sbjct: 703 FVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY 760


>gi|21361151 transducin-like enhancer protein 2 isoform 1 [Homo
           sapiens]
          Length = 743

 Score =  986 bits (2548), Expect = 0.0
 Identities = 524/777 (67%), Positives = 608/777 (78%), Gaps = 41/777 (5%)

Query: 1   MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60
           M+PQ RHPTP Q+ GQPFKF+I E  DRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH
Sbjct: 1   MYPQGRHPTPLQS-GQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 59

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN 120
           YVMYYEMSYGLNIEMHKQ EI KRL+ ICAQ+IPFL+QEHQQQV QAVERAKQVT+ ELN
Sbjct: 60  YVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELN 119

Query: 121 AIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSA-GLLALSSALSGQSHLA- 178
           ++IGQQ    Q LSH H PPVPLTP P+GL       +GGSA GLLALS AL+ Q+ LA 
Sbjct: 120 SLIGQQ---LQPLSH-HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLAA 168

Query: 179 -IKDDKKHHDAEHHR-DREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKD-SS 235
            +K+D+   +AE  R +R P  S S   P+SL   ++R +GP       K++ D+K+ S 
Sbjct: 169 AVKEDRAGVEAEGSRVERAPSRSASPSPPESLV-EEERPSGPGGGG---KQRADEKEPSG 224

Query: 236 HYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSAS 295
            Y+SD DKSD NLVVD   ED  S   SPA +P    +      ++D   SPAS ASS  
Sbjct: 225 PYESDEDKSDYNLVVD---EDQPSEPPSPATTPCGK-VPICIPARRDLVDSPASLASSLG 280

Query: 296 STSLKSKEMSLHE-KASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKP-PAIDPLVNQ 353
           S   ++KE+ L++  ASTP  KS   +P  D  TPG S+   L     KP P+ D     
Sbjct: 281 SPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTD----- 335

Query: 354 AAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAY 413
            +  LR+PL +  P+   F +  H+ +NG+L+ P ++Y SLH +SPQ+S++      V Y
Sbjct: 336 -SVALRSPLTLSSPFTTSFSLGSHSTLNGDLSVP-SSYVSLH-LSPQVSSS------VVY 386

Query: 414 GRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPR 473
           GRSP++ F+  PH+R  ++  +L  IPGGKPAYSFHV+ADGQMQPVPFP DAL+G GIPR
Sbjct: 387 GRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPR 446

Query: 474 HARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYI 533
           HARQ++TL HGEVVCAVTIS  T+HVYTGGKGCVKVWD+  PG K+PV+QLDCLNRDNYI
Sbjct: 447 HARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYI 506

Query: 534 RSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCC 593
           RSCKLLPDG +LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALA+SPD+KVCFSCC
Sbjct: 507 RSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC 566

Query: 594 SDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ 653
           SDGNI VWDL NQT+VRQFQGHTDGASCIDIS+ GT+LWTGGLDNTVR WDLREGRQLQQ
Sbjct: 567 SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQ 626

Query: 654 HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWF 713
           HDF+SQIFSLG+CP  +WLAVGMESSNVE+LHV KP+KYQLHLHESCVLSLKFA CG+WF
Sbjct: 627 HDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWF 686

Query: 714 VSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 770
           VSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 687 VSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 743


>gi|221219048 transducin-like enhancer protein 2 isoform 2 [Homo
           sapiens]
          Length = 706

 Score =  861 bits (2225), Expect = 0.0
 Identities = 466/714 (65%), Positives = 545/714 (76%), Gaps = 40/714 (5%)

Query: 3   PQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYV 62
           P S   TP Q+ GQPFKF+I E  DRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYV
Sbjct: 16  PASGLQTPLQS-GQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYV 74

Query: 63  MYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAI 122
           MYYEMSYGLNIEMHKQ EI KRL+ ICAQ+IPFL+QEHQQQV QAVERAKQVT+ ELN++
Sbjct: 75  MYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSL 134

Query: 123 IGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSA-GLLALSSALSGQSHLA--I 179
           IGQQQLQ   LSH H PPVPLTP P+GL       +GGSA GLLALS AL+ Q+ LA  +
Sbjct: 135 IGQQQLQP--LSH-HAPPVPLTPRPAGL-------VGGSATGLLALSGALAAQAQLAAAV 184

Query: 180 KDDKKHHDAEHHR-DREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKD-SSHY 237
           K+D+   +AE  R +R P  S S   P+SL   ++R +GP       K++ D+K+ S  Y
Sbjct: 185 KEDRAGVEAEGSRVERAPSRSASPSPPESLV-EEERPSGPGGGG---KQRADEKEPSGPY 240

Query: 238 DSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASST 297
           +SD DKSD NLVVD   ED  S   SPA +P    +      ++D   SPAS ASS  S 
Sbjct: 241 ESDEDKSDYNLVVD---EDQPSEPPSPATTPCGK-VPICIPARRDLVDSPASLASSLGSP 296

Query: 298 SLKSKEMSLHE-KASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKP-PAIDPLVNQAA 355
             ++KE+ L++  ASTP  KS   +P  D  TPG S+   L     KP P+ D      +
Sbjct: 297 LPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTD------S 350

Query: 356 AGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGR 415
             LR+PL +  P+   F +  H+ +NG+L+ P ++Y SLH +SPQ+S++      V YGR
Sbjct: 351 VALRSPLTLSSPFTTSFSLGSHSTLNGDLSVP-SSYVSLH-LSPQVSSS------VVYGR 402

Query: 416 SPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHA 475
           SP++ F+  PH+R  ++  +L  IPGGKPAYSFHV+ADGQMQPVPFP DAL+G GIPRHA
Sbjct: 403 SPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHA 462

Query: 476 RQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRS 535
           RQ++TL HGEVVCAVTIS  T+HVYTGGKGCVKVWD+  PG K+PV+QLDCLNRDNYIRS
Sbjct: 463 RQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRS 522

Query: 536 CKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSD 595
           CKLLPDG +LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALA+SPD+KVCFSCCSD
Sbjct: 523 CKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSD 582

Query: 596 GNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHD 655
           GNI VWDL NQT+VRQFQGHTDGASCIDIS+ GT+LWTGGLDNTVR WDLREGRQLQQHD
Sbjct: 583 GNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHD 642

Query: 656 FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYC 709
           F+SQIFSLG+CP  +WLAVGMESSNVE+LHV KP+KYQLHLHESCVLSLKFA C
Sbjct: 643 FSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASC 696


>gi|221219050 transducin-like enhancer protein 2 isoform 3 [Homo
           sapiens]
          Length = 621

 Score =  808 bits (2086), Expect = 0.0
 Identities = 435/716 (60%), Positives = 502/716 (70%), Gaps = 97/716 (13%)

Query: 57  MQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTM 116
           MQRHYVMYYEMSYGLNIEMHKQ EI KRL+ ICAQ+IPFL+QEHQQQV QAVERAKQVT+
Sbjct: 1   MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTV 60

Query: 117 AELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSH 176
            ELN++IG         S    PP  L                                 
Sbjct: 61  GELNSLIG---------SASPSPPESL--------------------------------- 78

Query: 177 LAIKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSH 236
                       E  R   PG           R  +K  +GP  S++ K           
Sbjct: 79  -----------VEEERPSGPGGGG------KQRADEKEPSGPYESDEDK----------- 110

Query: 237 YDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASS 296
                  SD NLVVD   ED  S   SPA +P    +      ++D   SPAS ASS  S
Sbjct: 111 -------SDYNLVVD---EDQPSEPPSPATTPC-GKVPICIPARRDLVDSPASLASSLGS 159

Query: 297 TSLKSKEMSLHE-KASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKP-PAIDPLVNQA 354
              ++KE+ L++  ASTP  KS   +P  D  TPG S+   L     KP P+ D      
Sbjct: 160 PLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTD------ 213

Query: 355 AAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYG 414
           +  LR+PL +  P+   F +  H+ +NG+L+ P ++Y SLH +SPQ+S++      V YG
Sbjct: 214 SVALRSPLTLSSPFTTSFSLGSHSTLNGDLSVP-SSYVSLH-LSPQVSSS------VVYG 265

Query: 415 RSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRH 474
           RSP++ F+  PH+R  ++  +L  IPGGKPAYSFHV+ADGQMQPVPFP DAL+G GIPRH
Sbjct: 266 RSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRH 325

Query: 475 ARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIR 534
           ARQ++TL HGEVVCAVTIS  T+HVYTGGKGCVKVWD+  PG K+PV+QLDCLNRDNYIR
Sbjct: 326 ARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIR 385

Query: 535 SCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCS 594
           SCKLLPDG +LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALA+SPD+KVCFSCCS
Sbjct: 386 SCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCS 445

Query: 595 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH 654
           DGNI VWDL NQT+VRQFQGHTDGASCIDIS+ GT+LWTGGLDNTVR WDLREGRQLQQH
Sbjct: 446 DGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQH 505

Query: 655 DFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFV 714
           DF+SQIFSLG+CP  +WLAVGMESSNVE+LHV KP+KYQLHLHESCVLSLKFA CG+WFV
Sbjct: 506 DFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFV 565

Query: 715 STGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY 770
           STGKDNLLNAWRTPYGASIFQSKESSSVLSCDIS ++KYIVTGSGDKKATVYEV+Y
Sbjct: 566 STGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY 621


>gi|5706731 amino-terminal enhancer of split isoform b [Homo
           sapiens]
          Length = 197

 Score =  241 bits (615), Expect = 2e-63
 Identities = 128/193 (66%), Positives = 147/193 (76%), Gaps = 4/193 (2%)

Query: 1   MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60
           MFPQSRH        Q  KFT  +S DRIK+EFQ LQAQYHSLKLEC+KLASEK+EMQRH
Sbjct: 2   MFPQSRHSGSSHLP-QQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRH 60

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN 120
           YVMYYEMSYGLNIEMHKQ EI KRLN ICAQV+P+LSQEHQQQV  A+ERAKQVT  ELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELN 120

Query: 121 AIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIK 180
           +II +QQLQA  LS      +PLTP P GLQPP +P +    GLL+LS AL  Q+HL+ K
Sbjct: 121 SII-RQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLS-ALGSQAHLS-K 177

Query: 181 DDKKHHDAEHHRD 193
           +DK  HD + H++
Sbjct: 178 EDKNGHDGDTHQE 190


>gi|39812027 amino-terminal enhancer of split isoform c [Homo
           sapiens]
          Length = 196

 Score =  239 bits (609), Expect = 9e-63
 Identities = 127/193 (65%), Positives = 146/193 (75%), Gaps = 5/193 (2%)

Query: 1   MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRH 60
           MFPQSRH        Q  KFT  +S DRIK+EFQ LQAQYHSLKLEC+KLASEK+EMQRH
Sbjct: 2   MFPQSRHSGSSHLP-QQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRH 60

Query: 61  YVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELN 120
           YVMYYEMSYGLNIEMHKQ EI KRLN ICAQV+P+LSQEHQQQV  A+ERAKQVT  ELN
Sbjct: 61  YVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELN 120

Query: 121 AIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIK 180
           +II  +QLQA  LS      +PLTP P GLQPP +P +    GLL+LS AL  Q+HL+ K
Sbjct: 121 SII--RQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLS-ALGSQAHLS-K 176

Query: 181 DDKKHHDAEHHRD 193
           +DK  HD + H++
Sbjct: 177 EDKNGHDGDTHQE 189


>gi|39812019 amino-terminal enhancer of split isoform a [Homo
           sapiens]
          Length = 264

 Score =  233 bits (594), Expect = 5e-61
 Identities = 121/178 (67%), Positives = 140/178 (78%), Gaps = 3/178 (1%)

Query: 16  QPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEM 75
           Q  KFT  +S DRIK+EFQ LQAQYHSLKLEC+KLASEK+EMQRHYVMYYEMSYGLNIEM
Sbjct: 83  QQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEM 142

Query: 76  HKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQLQAQHLSH 135
           HKQ EI KRLN ICAQV+P+LSQEHQQQV  A+ERAKQVT  ELN+II +QQLQA  LS 
Sbjct: 143 HKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSII-RQQLQAHQLSQ 201

Query: 136 GHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIKDDKKHHDAEHHRD 193
                +PLTP P GLQPP +P +    GLL+LS AL  Q+HL+ K+DK  HD + H++
Sbjct: 202 LQALALPLTPLPVGLQPPSLPAVSAGTGLLSLS-ALGSQAHLS-KEDKNGHDGDTHQE 257


>gi|221136834 transducin-like enhancer of split 6 isoform 1 [Homo
           sapiens]
          Length = 572

 Score =  198 bits (503), Expect = 2e-50
 Identities = 106/315 (33%), Positives = 179/315 (56%), Gaps = 10/315 (3%)

Query: 463 PDALIGPG----IPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHP--G 516
           PDAL G      +P    ++  L HGE+V A  IS+ TRHV+T G+  +KVW ++     
Sbjct: 261 PDALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAE 320

Query: 517 NKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGG-EASTLSIWDLAAPTPRIKAELTSSAP 575
           ++ P S L       ++R+C L  +  +L+ GG   +++S+WDLAAP+  +K +L  +  
Sbjct: 321 DRFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGL 380

Query: 576 ACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGG 635
            C AL  + D+ + F+  + G + +WDL +Q++VR  +G+ DG   I +   G  +WTGG
Sbjct: 381 NCQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVK--GYNIWTGG 438

Query: 636 LDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLH 695
            D  +R WD R   +  ++ F SQI SL + P  +W+ +GM +    +   +   ++ + 
Sbjct: 439 PDACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVG 498

Query: 696 LHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIV 755
             +S +LS+KF+  G+W+ S G D+ L  +  P G  +F+  E S V  CD+S +++ +V
Sbjct: 499 QKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVV 558

Query: 756 TGSGDKKATVYEVIY 770
           TGSG+  A+VY++ Y
Sbjct: 559 TGSGE-HASVYQITY 572


>gi|13376099 transducin-like enhancer of split 6 isoform 2 [Homo
           sapiens]
          Length = 449

 Score =  198 bits (503), Expect = 2e-50
 Identities = 106/315 (33%), Positives = 179/315 (56%), Gaps = 10/315 (3%)

Query: 463 PDALIGPG----IPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHP--G 516
           PDAL G      +P    ++  L HGE+V A  IS+ TRHV+T G+  +KVW ++     
Sbjct: 138 PDALPGQSKRLAVPCKLEKMRILAHGELVLATAISSFTRHVFTCGRRGIKVWSLTGQVAE 197

Query: 517 NKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGG-EASTLSIWDLAAPTPRIKAELTSSAP 575
           ++ P S L       ++R+C L  +  +L+ GG   +++S+WDLAAP+  +K +L  +  
Sbjct: 198 DRFPESHLPIQTPGAFLRTCLLSSNSRSLLTGGYNLASVSVWDLAAPSLHVKEQLPCAGL 257

Query: 576 ACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGG 635
            C AL  + D+ + F+  + G + +WDL +Q++VR  +G+ DG   I +   G  +WTGG
Sbjct: 258 NCQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVK--GYNIWTGG 315

Query: 636 LDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLH 695
            D  +R WD R   +  ++ F SQI SL + P  +W+ +GM +    +   +   ++ + 
Sbjct: 316 PDACLRCWDQRTIMKPLEYQFKSQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMVG 375

Query: 696 LHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIV 755
             +S +LS+KF+  G+W+ S G D+ L  +  P G  +F+  E S V  CD+S +++ +V
Sbjct: 376 QKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMSPVTCCDVSSNNRLVV 435

Query: 756 TGSGDKKATVYEVIY 770
           TGSG+  A+VY++ Y
Sbjct: 436 TGSGE-HASVYQITY 449


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 60/259 (23%), Positives = 113/259 (43%), Gaps = 12/259 (4%)

Query: 475 ARQINTLNHGEVVCAVTISNPTRHVYTGGKG--CVKVWDISHPGNKSPVSQLDCLNRDNY 532
           +R      H + V  V  S P+ H+   G     V++W + +   +S V +         
Sbjct: 14  SRAYRFTGHKDAVTCVNFS-PSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTAT---- 67

Query: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592
           +RS     DG + +   +  T+ +W  A    +    L+           SPD ++  S 
Sbjct: 68  VRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSA 125

Query: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
             D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ
Sbjct: 126 SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ 185

Query: 653 QHDF-TSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCG 710
            +   ++ +  L + P+G +L      S +++L + +    Y LH H+    ++ F+  G
Sbjct: 186 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 245

Query: 711 KWFVSTGKDNLLNAWRTPY 729
           ++F S G D  +  W++ +
Sbjct: 246 EYFASGGSDEQVMVWKSNF 264



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 35/133 (26%), Positives = 58/133 (43%), Gaps = 2/133 (1%)

Query: 595 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLR-EGRQLQQ 653
           D  + VW +  Q+   +F GH D  +C++ S  G  L +G  D TVR W    +G     
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 654 HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKW 712
              T+ + S+ +C  G+      +   V+V   ++    + L  H + V   KF+  G+ 
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 713 FVSTGKDNLLNAW 725
            VS   D  +  W
Sbjct: 122 IVSASDDKTVKLW 134


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 60/259 (23%), Positives = 113/259 (43%), Gaps = 12/259 (4%)

Query: 475 ARQINTLNHGEVVCAVTISNPTRHVYTGGKG--CVKVWDISHPGNKSPVSQLDCLNRDNY 532
           +R      H + V  V  S P+ H+   G     V++W + +   +S V +         
Sbjct: 52  SRAYRFTGHKDAVTCVNFS-PSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTAT---- 105

Query: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592
           +RS     DG + +   +  T+ +W  A    +    L+           SPD ++  S 
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSA 163

Query: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
             D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ
Sbjct: 164 SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ 223

Query: 653 QHDF-TSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCG 710
            +   ++ +  L + P+G +L      S +++L + +    Y LH H+    ++ F+  G
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283

Query: 711 KWFVSTGKDNLLNAWRTPY 729
           ++F S G D  +  W++ +
Sbjct: 284 EYFASGGSDEQVMVWKSNF 302



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 43/166 (25%), Positives = 77/166 (46%), Gaps = 7/166 (4%)

Query: 607 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQ---IFSL 663
           +L R F+GH D  +C+D S +  +L +G +D+ +  W ++   Q + + FT     +  +
Sbjct: 10  SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKP--QSRAYRFTGHKDAVTCV 67

Query: 664 GYCPTGEWLAVGMESSNVEVLHVN-KPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLL 722
            + P+G  LA G     V +   N K +      H + V S+ F   G+ FV+   D  +
Sbjct: 68  NFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127

Query: 723 NAWRTPYGASIFQSKESSSVLSC-DISVDDKYIVTGSGDKKATVYE 767
             W T     +F   +  + + C   S D + IV+ S DK   +++
Sbjct: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 2/167 (1%)

Query: 561 APTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGAS 620
           A  P ++        A   +  S ++K   S   D  + VW +  Q+   +F GH D  +
Sbjct: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65

Query: 621 CIDISNDGTKLWTGGLDNTVRSWDLR-EGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESS 679
           C++ S  G  L +G  D TVR W    +G        T+ + S+ +C  G+      +  
Sbjct: 66  CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125

Query: 680 NVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAW 725
            V+V   ++    + L  H + V   KF+  G+  VS   D  +  W
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 60/259 (23%), Positives = 113/259 (43%), Gaps = 12/259 (4%)

Query: 475 ARQINTLNHGEVVCAVTISNPTRHVYTGGKG--CVKVWDISHPGNKSPVSQLDCLNRDNY 532
           +R      H + V  V  S P+ H+   G     V++W + +   +S V +         
Sbjct: 52  SRAYRFTGHKDAVTCVNFS-PSGHLLASGSRDKTVRIW-VPNVKGESTVFRAHTAT---- 105

Query: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592
           +RS     DG + +   +  T+ +W  A    +    L+           SPD ++  S 
Sbjct: 106 VRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSA 163

Query: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
             D  + +WD  ++  V  +  H    + +D    GT +   G+DNTV+ WD+R  R LQ
Sbjct: 164 SDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQ 223

Query: 653 QHDF-TSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCG 710
            +   ++ +  L + P+G +L      S +++L + +    Y LH H+    ++ F+  G
Sbjct: 224 HYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTG 283

Query: 711 KWFVSTGKDNLLNAWRTPY 729
           ++F S G D  +  W++ +
Sbjct: 284 EYFASGGSDEQVMVWKSNF 302



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 43/166 (25%), Positives = 77/166 (46%), Gaps = 7/166 (4%)

Query: 607 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQ---IFSL 663
           +L R F+GH D  +C+D S +  +L +G +D+ +  W ++   Q + + FT     +  +
Sbjct: 10  SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKP--QSRAYRFTGHKDAVTCV 67

Query: 664 GYCPTGEWLAVGMESSNVEVLHVN-KPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLL 722
            + P+G  LA G     V +   N K +      H + V S+ F   G+ FV+   D  +
Sbjct: 68  NFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTV 127

Query: 723 NAWRTPYGASIFQSKESSSVLSC-DISVDDKYIVTGSGDKKATVYE 767
             W T     +F   +  + + C   S D + IV+ S DK   +++
Sbjct: 128 KVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 173



 Score = 60.1 bits (144), Expect = 8e-09
 Identities = 41/167 (24%), Positives = 69/167 (41%), Gaps = 2/167 (1%)

Query: 561 APTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGAS 620
           A  P ++        A   +  S ++K   S   D  + VW +  Q+   +F GH D  +
Sbjct: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65

Query: 621 CIDISNDGTKLWTGGLDNTVRSWDLR-EGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESS 679
           C++ S  G  L +G  D TVR W    +G        T+ + S+ +C  G+      +  
Sbjct: 66  CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 125

Query: 680 NVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAW 725
            V+V   ++    + L  H + V   KF+  G+  VS   D  +  W
Sbjct: 126 TVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW 172


>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
           isoform a [Homo sapiens]
          Length = 353

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 73/299 (24%), Positives = 125/299 (41%), Gaps = 23/299 (7%)

Query: 483 HG-EVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPD 541
           HG +V+C     +  R V +   G V VWD S   NK     + C     ++ +C   P 
Sbjct: 62  HGNKVLCMDWCKDKRRIVSSSQDGKVIVWD-SFTTNKEHAVTMPC----TWVMACAYAPS 116

Query: 542 GCTLIVGGEASTLSIWDLA-------APTPRIKAELTSSAPACYALAISPDSKVCFSCCS 594
           GC +  GG  +  S++ L        A   +  A  T+   AC   + +       +   
Sbjct: 117 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSAC---SFTNSDMQILTASG 173

Query: 595 DGNIAVWDLHNQTLVRQFQGHTDGASCIDI--SNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
           DG  A+WD+ +  L++ F GH     C+D+  S  G    +GG D     WD+R G+ +Q
Sbjct: 174 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 233

Query: 653 QHD-FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVL---SLKFAY 708
             +   S I S+ Y P+G+  A G + +   +  +    +  ++  ES +    S+ F+ 
Sbjct: 234 AFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSL 293

Query: 709 CGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISVDDKYIVTGSGDKKATVY 766
            G+   +   D  +N W    G+ +       + V +  +S D     +GS D    V+
Sbjct: 294 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 38/173 (21%), Positives = 70/173 (40%), Gaps = 17/173 (9%)

Query: 610 RQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFT---SQIFSLGYC 666
           R  +GH +   C+D   D  ++ +   D  V  WD       ++H  T   + + +  Y 
Sbjct: 57  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMACAYA 114

Query: 667 PTGEWLAVGMESSNVEV--LHVNKPD-----KYQLHLHESCVLSLKFAYCGKWFVSTGKD 719
           P+G  +A G   +   V  L  +K +     K  + +H + + +  F       ++   D
Sbjct: 115 PSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGD 174

Query: 720 NLLNAWRTPYGASIFQS--KESSSVLSCDISVDD--KYIVTGSGDKKATVYEV 768
                W    G  + QS     + VL  D++  +     V+G  DKKA V+++
Sbjct: 175 GTCALWDVESG-QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 226


>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
           isoform b [Homo sapiens]
          Length = 395

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 73/299 (24%), Positives = 125/299 (41%), Gaps = 23/299 (7%)

Query: 483 HG-EVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPD 541
           HG +V+C     +  R V +   G V VWD S   NK     + C     ++ +C   P 
Sbjct: 104 HGNKVLCMDWCKDKRRIVSSSQDGKVIVWD-SFTTNKEHAVTMPC----TWVMACAYAPS 158

Query: 542 GCTLIVGGEASTLSIWDLA-------APTPRIKAELTSSAPACYALAISPDSKVCFSCCS 594
           GC +  GG  +  S++ L        A   +  A  T+   AC   + +       +   
Sbjct: 159 GCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSAC---SFTNSDMQILTASG 215

Query: 595 DGNIAVWDLHNQTLVRQFQGHTDGASCIDI--SNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
           DG  A+WD+ +  L++ F GH     C+D+  S  G    +GG D     WD+R G+ +Q
Sbjct: 216 DGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQ 275

Query: 653 QHD-FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVL---SLKFAY 708
             +   S I S+ Y P+G+  A G + +   +  +    +  ++  ES +    S+ F+ 
Sbjct: 276 AFETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSL 335

Query: 709 CGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISVDDKYIVTGSGDKKATVY 766
            G+   +   D  +N W    G+ +       + V +  +S D     +GS D    V+
Sbjct: 336 SGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 38/173 (21%), Positives = 70/173 (40%), Gaps = 17/173 (9%)

Query: 610 RQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFT---SQIFSLGYC 666
           R  +GH +   C+D   D  ++ +   D  V  WD       ++H  T   + + +  Y 
Sbjct: 99  RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD--SFTTNKEHAVTMPCTWVMACAYA 156

Query: 667 PTGEWLAVGMESSNVEV--LHVNKPD-----KYQLHLHESCVLSLKFAYCGKWFVSTGKD 719
           P+G  +A G   +   V  L  +K +     K  + +H + + +  F       ++   D
Sbjct: 157 PSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGD 216

Query: 720 NLLNAWRTPYGASIFQS--KESSSVLSCDISVDD--KYIVTGSGDKKATVYEV 768
                W    G  + QS     + VL  D++  +     V+G  DKKA V+++
Sbjct: 217 GTCALWDVESG-QLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDM 268


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 85.5 bits (210), Expect = 2e-16
 Identities = 64/259 (24%), Positives = 108/259 (41%), Gaps = 10/259 (3%)

Query: 474 HARQINTLNHGEVVCAVTISNPTRHVYTGGKG-CVKVWDISHPGNKSPVSQLDCLNRDNY 532
           HAR    + H +VV +V  S     + +  +   V++W    P  +   S+         
Sbjct: 50  HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWI---PDKRGKFSEFKAHTAP-- 104

Query: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592
           +RS     DG  L    E  ++ +W +     R    L            SPD ++  SC
Sbjct: 105 VRSVDFSADGQFLATASEDKSIKVWSMYRQ--RFLYSLYRHTHWVRCAKFSPDGRLIVSC 162

Query: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
             D  I +WD  N+  V  F      A+ +D +  GT + + G D TV+ WD+R  + LQ
Sbjct: 163 SEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQ 222

Query: 653 QHDFTS-QIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK-YQLHLHESCVLSLKFAYCG 710
            +   S  +  + + P+G +L        +++L + +    Y L  H   V ++ F+  G
Sbjct: 223 HYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGG 282

Query: 711 KWFVSTGKDNLLNAWRTPY 729
           + F S G D  +  WRT +
Sbjct: 283 ELFASGGADTQVLLWRTNF 301



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 46/212 (21%), Positives = 87/212 (41%), Gaps = 3/212 (1%)

Query: 560 AAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGA 619
           A   P ++        A  +L +SP+ K   +   D  + +W+        ++ GH D  
Sbjct: 4   ATEDPVLERYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVV 63

Query: 620 SCIDISNDGTKLWTGGLDNTVRSW-DLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMES 678
           + +  S  G  L +   D TVR W   + G+  +    T+ + S+ +   G++LA   E 
Sbjct: 64  TSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASED 123

Query: 679 SNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSK 737
            +++V  + +    Y L+ H   V   KF+  G+  VS  +D  +  W T     +    
Sbjct: 124 KSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS 183

Query: 738 ESSSVLS-CDISVDDKYIVTGSGDKKATVYEV 768
           +S    +  D +     I +   D+   V++V
Sbjct: 184 DSVGFANFVDFNPSGTCIASAGSDQTVKVWDV 215


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 65/244 (26%), Positives = 104/244 (42%), Gaps = 14/244 (5%)

Query: 536 CKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSD 595
           CK  P+G TL   G    + +W++        A L   + A   L  + D  + FS  +D
Sbjct: 72  CKFHPNGSTLASAGFDRLILLWNVYGDCDNY-ATLKGHSGAVMELHYNTDGSMLFSASTD 130

Query: 596 GNIAVWDLHNQTLVRQFQGHTDGA-SCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH 654
             +AVWD      V++ +GHT    SC         + TG  D TV+ WD+R+   +Q  
Sbjct: 131 KTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTF 190

Query: 655 DFTSQIFSLGYCPTGEWLAVGMESSNVEV--LHVNKPDKYQLHLHESCVLSLKFAYCGKW 712
             T Q+ ++ +  T + +  G   ++++V  L  NK   Y +  H   V  L  +  G +
Sbjct: 191 QNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKL-TYTMRGHADSVTGLSLSSEGSY 249

Query: 713 FVSTGKDNLLNAWRT-PYG-----ASIFQSKE---SSSVLSCDISVDDKYIVTGSGDKKA 763
            +S   DN +  W   P+        IFQ        ++L C  S D   I  GS D+  
Sbjct: 250 LLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFV 309

Query: 764 TVYE 767
            V++
Sbjct: 310 YVWD 313



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 50/181 (27%), Positives = 81/181 (44%), Gaps = 22/181 (12%)

Query: 507 VKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLI-VGGEASTLSIWDLAAPTPR 565
           V VWD S  G +  V +L      +++ SC     G  L+  G +  T+ +WD+     R
Sbjct: 133 VAVWD-SETGER--VKRLK--GHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDI-----R 182

Query: 566 IKAELTSSAPACYALAIS--PDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCID 623
            KA + +       LA++    S    S   D +I VWDL    L    +GH D  + + 
Sbjct: 183 KKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLS 242

Query: 624 ISNDGTKLWTGGLDNTVRSWDLREGRQLQQ---------HDFTSQIFSLGYCPTGEWLAV 674
           +S++G+ L +  +DNTVR WD+R     ++         H+F   +    + P G  +A 
Sbjct: 243 LSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAA 302

Query: 675 G 675
           G
Sbjct: 303 G 303



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 35/155 (22%), Positives = 58/155 (37%), Gaps = 16/155 (10%)

Query: 505 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTP 564
           G VK+WDI         + +        + +         +I GG  + + +WDL     
Sbjct: 174 GTVKLWDIRKK------AAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQN-- 225

Query: 565 RIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLH----NQTLVRQFQGHTDGAS 620
           ++   +   A +   L++S +     S   D  + VWD+      +  V+ FQG+     
Sbjct: 226 KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFE 285

Query: 621 C----IDISNDGTKLWTGGLDNTVRSWDLREGRQL 651
                   S DG+K+  G  D  V  WD    R L
Sbjct: 286 KNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRIL 320



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 31/150 (20%), Positives = 61/150 (40%), Gaps = 12/150 (8%)

Query: 473 RHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCLNRDN 531
           R    I T  +   V AVT ++ +  + +GG    +KVWD+    NK   +        +
Sbjct: 182 RKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQ--NKLTYTMR---GHAD 236

Query: 532 YIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPR------IKAELTSSAPACYALAISPD 585
            +    L  +G  L+     +T+ +WD+    P+       +  + +        + SPD
Sbjct: 237 SVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPD 296

Query: 586 SKVCFSCCSDGNIAVWDLHNQTLVRQFQGH 615
                +  +D  + VWD  ++ ++ +  GH
Sbjct: 297 GSKIAAGSADRFVYVWDTTSRRILYKLPGH 326



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 38/169 (22%), Positives = 61/169 (36%), Gaps = 8/169 (4%)

Query: 606 QTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSW----DLREGRQLQQHDFTSQIF 661
           Q  +    GH     C     +G+ L + G D  +  W    D      L+ H  +  + 
Sbjct: 56  QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGH--SGAVM 113

Query: 662 SLGYCPTGEWLAVGMESSNVEVLHVNKPDKY-QLHLHESCVLSLKFAYCGKWFVSTGKDN 720
            L Y   G  L        V V      ++  +L  H S V S   A  G   V TG D+
Sbjct: 114 ELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDD 173

Query: 721 -LLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEV 768
             +  W     A+I   + +  VL+   +     I++G  D    V+++
Sbjct: 174 GTVKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWDL 222


>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
           sapiens]
          Length = 522

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 56/213 (26%), Positives = 92/213 (43%), Gaps = 6/213 (2%)

Query: 553 TLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQF 612
           ++ +W L +  P   A++         +   P  +   + C D +  +WDL  Q  +   
Sbjct: 304 SVKLWSLDSDEP--VADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ 361

Query: 613 QGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ-QHDFTSQIFSLGYCPTGEW 671
           +GH+ G   I    DG+   TGGLD   R WDLR GR +        +I+ + + P G  
Sbjct: 362 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH 421

Query: 672 LAVGMESSNVEVLHV-NKPDKYQLHLHESCVLSLKFAYCGKWFVSTGK-DNLLNAWRTPY 729
           +A G   +  +V  +  +   Y +  H++ V  +KF      F+ TG  DN    W  P 
Sbjct: 422 IATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPG 481

Query: 730 GASI-FQSKESSSVLSCDISVDDKYIVTGSGDK 761
            + +   +     V+  DIS D + I T S D+
Sbjct: 482 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDR 514



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 40/198 (20%), Positives = 74/198 (37%), Gaps = 13/198 (6%)

Query: 583 SPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGA--------SCIDISNDGTKLWTG 634
           SP+SK+  + C  G   +W + +  L+   +GH            S + +      L + 
Sbjct: 240 SPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASC 299

Query: 635 GLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQ 693
             D +V+ W L     +      T ++  + + P+G +L       +  +  +   ++  
Sbjct: 300 AADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEI- 358

Query: 694 LHL--HESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISVD 750
           LH   H   V  + F   G    + G D     W    G  I F       +   + S +
Sbjct: 359 LHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPN 418

Query: 751 DKYIVTGSGDKKATVYEV 768
             +I TGSGD    V+++
Sbjct: 419 GYHIATGSGDNTCKVWDL 436



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 22/105 (20%), Positives = 38/105 (36%), Gaps = 3/105 (2%)

Query: 540 PDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISP-DSKVCFSCCSDGNI 598
           P+G  +  G   +T  +WDL     R    + +       +   P       +   D   
Sbjct: 417 PNGYHIATGSGDNTCKVWDLRQR--RCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTA 474

Query: 599 AVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSW 643
            +W     + ++   GH      +DIS+DG  + T   D T + W
Sbjct: 475 KIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 519


>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
           sapiens]
          Length = 340

 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 62/262 (23%), Positives = 106/262 (40%), Gaps = 11/262 (4%)

Query: 505 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTP 564
           G + VWD S+  NK     L    R +++ +C   P G  +  GG  +  SI++L +   
Sbjct: 77  GKLIVWD-SYTTNKVHAIPL----RSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREG 131

Query: 565 RIKAELTSSAPACY-ALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCID 623
            +K     SA   Y +     D     +   D   A+WD+        F GHT     + 
Sbjct: 132 NVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLA 191

Query: 624 ISNDGTKLWTGGLDNTVRSWDLREGRQLQQH-DFTSQIFSLGYCPTGEWLAVGMESSNVE 682
           +S D     +G  D + + WD+REG   Q      S I ++ + P GE +  G + ++  
Sbjct: 192 VSPDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCR 251

Query: 683 VLHVNKPDKYQLHLHESC---VLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKES 739
           +  +    +     HES    + S+ F+  G+   +   D   N W +     +      
Sbjct: 252 LFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGH 311

Query: 740 SSVLSC-DISVDDKYIVTGSGD 760
            + +SC  ++ D   + TGS D
Sbjct: 312 DNRVSCLGVTADGMAVATGSWD 333



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 50/198 (25%), Positives = 83/198 (41%), Gaps = 7/198 (3%)

Query: 532 YIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFS 591
           Y+  C+ L D   +   G+ +T ++WD+   T + K         C +LA+SPD  +  S
Sbjct: 145 YLSCCRFLDDNNIVTSSGD-TTCALWDIE--TGQQKTVFVGHTGDCMSLAVSPDFNLFIS 201

Query: 592 CCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQL 651
              D +  +WD+   T  + F GH    + I    +G  + TG  D + R +DLR  ++L
Sbjct: 202 GACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQEL 261

Query: 652 ---QQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQ-LHLHESCVLSLKFA 707
                      I S+ +  +G  L  G +  N  V    K ++   L  H++ V  L   
Sbjct: 262 ICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVT 321

Query: 708 YCGKWFVSTGKDNLLNAW 725
             G    +   D+ L  W
Sbjct: 322 ADGMAVATGSWDSFLKIW 339



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 34/159 (21%), Positives = 66/159 (41%), Gaps = 7/159 (4%)

Query: 488 CAVTISNPTRHVYTGGK--GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTL 545
           C     +P  +++  G      K+WD+     +    +      ++ I +    P+G  +
Sbjct: 187 CMSLAVSPDFNLFISGACDASAKLWDV-----REGTCRQTFTGHESDINAICFFPNGEAI 241

Query: 546 IVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHN 605
             G + ++  ++DL A    I     S      ++A S   ++ F+   D N  VWD   
Sbjct: 242 CTGSDDASCRLFDLRADQELICFSHESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMK 301

Query: 606 QTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 644
              V    GH +  SC+ ++ DG  + TG  D+ ++ W+
Sbjct: 302 SERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340



 Score = 38.1 bits (87), Expect = 0.031
 Identities = 53/220 (24%), Positives = 80/220 (36%), Gaps = 33/220 (15%)

Query: 565 RIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDI 624
           R +  L       YA+  + DSK+  S   DG + VWD +    V      +        
Sbjct: 46  RTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAY 105

Query: 625 SNDGTKLWTGGLDNTVRSWDL--REG-----RQLQQH----------DFTSQIFSLGYCP 667
           +  G  +  GGLDN    ++L  REG     R+L  H          D  + + S G   
Sbjct: 106 APSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSGDTT 165

Query: 668 TGEWLAVGMESSNVEVLHVN-------KPDKYQLHLHESCVLSLKF-----AYCGKWFVS 715
              W     +   V V H          PD + L +  +C  S K        C + F  
Sbjct: 166 CALWDIETGQQKTVFVGHTGDCMSLAVSPD-FNLFISGACDASAKLWDVREGTCRQTF-- 222

Query: 716 TGKDNLLNA-WRTPYGASIFQSKESSSVLSCDISVDDKYI 754
           TG ++ +NA    P G +I    + +S    D+  D + I
Sbjct: 223 TGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELI 262



 Score = 33.9 bits (76), Expect = 0.59
 Identities = 30/129 (23%), Positives = 60/129 (46%), Gaps = 7/129 (5%)

Query: 645 LREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK-YQLHLHESCVLS 703
           +R  R L+ H   ++I+++ +    + L    +   + V      +K + + L  S V++
Sbjct: 45  MRTRRTLRGH--LAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMT 102

Query: 704 LKFAYCGKWFVSTGKDNLLNAWRTPYG-ASIFQSKESSS---VLSCDISVDDKYIVTGSG 759
             +A  G +    G DN+ + +       ++  S+E S+    LSC   +DD  IVT SG
Sbjct: 103 CAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIVTSSG 162

Query: 760 DKKATVYEV 768
           D    ++++
Sbjct: 163 DTTCALWDI 171


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 61/263 (23%), Positives = 107/263 (40%), Gaps = 13/263 (4%)

Query: 505 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAA--P 562
           G + +WD S+  NK     L    R +++ +C   P G  +  GG  +  SI++L     
Sbjct: 77  GKLIIWD-SYTTNKMHAIPL----RSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREG 131

Query: 563 TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCI 622
             R+  EL              DS++  S   D   A+WD+        F GH+     +
Sbjct: 132 NVRVSRELPGHTGYLSCCRFLDDSQIVTS-SGDTTCALWDIETAQQTTTFTGHSGDVMSL 190

Query: 623 DISNDGTKLWTGGLDNTVRSWDLREGRQLQQH-DFTSQIFSLGYCPTGEWLAVGMESSNV 681
            +S D     +G  D + + WD+R+G   Q      S I ++ + P G   A G + +  
Sbjct: 191 SLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATC 250

Query: 682 EVLHVNKPDKYQLHLHESC---VLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKE 738
            +  +    +  L+ H++    + S+ F+  G+  ++   D   N W T  G        
Sbjct: 251 RLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAG 310

Query: 739 SSSVLSC-DISVDDKYIVTGSGD 760
             + +SC  ++ D   + TGS D
Sbjct: 311 HDNRVSCLGVTDDGMAVATGSWD 333



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 50/198 (25%), Positives = 84/198 (42%), Gaps = 7/198 (3%)

Query: 532 YIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFS 591
           Y+  C+ L D   +   G+ +T ++WD+   T +     T  +    +L++SPD +   S
Sbjct: 145 YLSCCRFLDDSQIVTSSGD-TTCALWDIE--TAQQTTTFTGHSGDVMSLSLSPDMRTFVS 201

Query: 592 CCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQ- 650
              D +  +WD+ +    + F GH    + +    +G    TG  D T R +DLR  ++ 
Sbjct: 202 GACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQEL 261

Query: 651 -LQQHD-FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKY-QLHLHESCVLSLKFA 707
            L  HD     I S+ +  +G  L  G +  N  V    K D+   L  H++ V  L   
Sbjct: 262 LLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVT 321

Query: 708 YCGKWFVSTGKDNLLNAW 725
             G    +   D+ L  W
Sbjct: 322 DDGMAVATGSWDSFLRIW 339



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 38/172 (22%), Positives = 71/172 (41%), Gaps = 7/172 (4%)

Query: 475 ARQINTLN-HGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCLNRDNY 532
           A+Q  T   H   V ++++S   R   +G      K+WDI     +  + +       + 
Sbjct: 174 AQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDI-----RDGMCRQSFTGHVSD 228

Query: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592
           I +    P+G     G + +T  ++DL A    +     +      ++A S   ++  + 
Sbjct: 229 INAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAG 288

Query: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 644
             D N  VWD           GH +  SC+ +++DG  + TG  D+ +R W+
Sbjct: 289 YDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIWN 340



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 34/149 (22%), Positives = 68/149 (45%), Gaps = 9/149 (6%)

Query: 626 NDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLH 685
           ND T +      ++V    +R  R L+ H   ++I+++ +      L    +   + +  
Sbjct: 26  NDATLVQITSNMDSVGRIQMRTRRTLRGH--LAKIYAMHWGYDSRLLVSASQDGKLIIWD 83

Query: 686 VNKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAW--RTPYGASIFQSKE---S 739
               +K + + L  S V++  +A  G +    G DN+ + +  +T  G ++  S+E    
Sbjct: 84  SYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREG-NVRVSRELPGH 142

Query: 740 SSVLSCDISVDDKYIVTGSGDKKATVYEV 768
           +  LSC   +DD  IVT SGD    ++++
Sbjct: 143 TGYLSCCRFLDDSQIVTSSGDTTCALWDI 171



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 21/86 (24%), Positives = 34/86 (39%), Gaps = 2/86 (2%)

Query: 565 RIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDI 624
           R +  L       YA+    DS++  S   DG + +WD +    +      +        
Sbjct: 46  RTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAY 105

Query: 625 SNDGTKLWTGGLDNTVRSWDL--REG 648
           +  G  +  GGLDN    ++L  REG
Sbjct: 106 APSGNYVACGGLDNICSIYNLKTREG 131


>gi|18677720 WD repeat and SOCS box-containing 1 isoform 1 [Homo
           sapiens]
          Length = 421

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 62/257 (24%), Positives = 98/257 (38%), Gaps = 35/257 (13%)

Query: 505 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEAS-TLSIWDLAAPT 563
           G +K+WD+ + G       L+ ++    +R     PDG  ++V      TL +WDL    
Sbjct: 150 GRIKIWDV-YTGKLL----LNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDG 204

Query: 564 PRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCID 623
             +K  L       Y+ A SPDS +  S  +   + +W++   T++R+ +GH       D
Sbjct: 205 NMMKV-LRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLEGHHHDVVACD 263

Query: 624 ISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEV 683
            S DG  L T   D  V  WD   G  L +       F   + P     A G        
Sbjct: 264 FSPDGALLATASYDTRVYIWDPHNGDILME-------FGHLFPPPTPIFAGG-------- 308

Query: 684 LHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVL 743
                        ++  V S+ F++ G    S   D ++  WR      + Q    S+ L
Sbjct: 309 ------------ANDRWVRSVSFSHDGLHVASLADDKMVRFWRIDEDYPV-QVAPLSNGL 355

Query: 744 SCDISVDDKYIVTGSGD 760
            C  S D   +  G+ D
Sbjct: 356 CCAFSTDGSVLAAGTHD 372



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 51/220 (23%), Positives = 87/220 (39%), Gaps = 24/220 (10%)

Query: 478 INTLNHGEVVCAVTISNPTRHVYTGGKG--CVKVWDISHPGNKSPVSQLDCLNRDNYIRS 535
           +N ++H EVV  +T +     +         ++VWD+   GN   V +       N++ S
Sbjct: 164 LNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMMKVLR----GHQNWVYS 219

Query: 536 CKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSD 595
           C   PD   L   G +  + +W++   T   K E         A   SPD  +  +   D
Sbjct: 220 CAFSPDSSMLCSVGASKAVFLWNMDKYTMIRKLE--GHHHDVVACDFSPDGALLATASYD 277

Query: 596 GNIAVWDLHNQTLVRQFQGH---------TDGAS-----CIDISNDGTKLWTGGLDNTVR 641
             + +WD HN  ++ +F GH           GA+      +  S+DG  + +   D  VR
Sbjct: 278 TRVYIWDPHNGDILMEF-GHLFPPPTPIFAGGANDRWVRSVSFSHDGLHVASLADDKMVR 336

Query: 642 SWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNV 681
            W + E   +Q    ++ +    +   G  LA G    +V
Sbjct: 337 FWRIDEDYPVQVAPLSNGL-CCAFSTDGSVLAAGTHDGSV 375



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 31/139 (22%), Positives = 60/139 (43%), Gaps = 10/139 (7%)

Query: 594 SDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTK-LWTGGLDNTVRSWDLREGRQLQ 652
           ++G I +WD++   L+     HT+    +  + DG+  L +   D T+R WDL++   + 
Sbjct: 148 NNGRIKIWDVYTGKLLLNLVDHTEVVRDLTFAPDGSLILVSASRDKTLRVWDLKDDGNMM 207

Query: 653 Q--HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKY----QLHLHESCVLSLKF 706
           +      + ++S  + P    L     S  V + ++   DKY    +L  H   V++  F
Sbjct: 208 KVLRGHQNWVYSCAFSPDSSMLCSVGASKAVFLWNM---DKYTMIRKLEGHHHDVVACDF 264

Query: 707 AYCGKWFVSTGKDNLLNAW 725
           +  G    +   D  +  W
Sbjct: 265 SPDGALLATASYDTRVYIW 283


>gi|8923881 WD SOCS-box protein 2 [Homo sapiens]
          Length = 404

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 59/257 (22%), Positives = 99/257 (38%), Gaps = 36/257 (14%)

Query: 505 GCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEAS-TLSIWDLAAPT 563
           G +K+W++     ++ +  L+     + +R     P G  ++V      TL IWDL    
Sbjct: 133 GQIKIWEV-----QTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHG 187

Query: 564 PRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCID 623
            +I+  L+      Y  +ISPD  +  S   + ++ +W + + TL+R+ +GH       D
Sbjct: 188 KQIQV-LSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCD 246

Query: 624 ISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEV 683
            S D   L T   D  V  WD   G +L+    T              +   M+ S+V  
Sbjct: 247 FSPDSALLVTASYDTNVIMWDPYTGERLRSLHHTQ-------------VDPAMDDSDV-- 291

Query: 684 LHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVL 743
                        H S + S+ F+  G +  +   D LL  W       I  +  ++  L
Sbjct: 292 -------------HISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG-L 337

Query: 744 SCDISVDDKYIVTGSGD 760
            C        I TG+ D
Sbjct: 338 CCTFFPHGGVIATGTRD 354



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 39/162 (24%), Positives = 67/162 (41%), Gaps = 8/162 (4%)

Query: 594 SDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTK-LWTGGLDNTVRSWDL-REGRQL 651
           +DG I +W++    L+    GH D    +  +  G+  L +   D T+R WDL + G+Q+
Sbjct: 131 NDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQI 190

Query: 652 QQHDFTSQ-IFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKY-QLHLHESCVLSLKFAYC 709
           Q      Q ++     P    L       +V +  +       +L  H+S V+S  F+  
Sbjct: 191 QVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPD 250

Query: 710 GKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDD 751
               V+   D  +  W  PY     +S   + V   D ++DD
Sbjct: 251 SALLVTASYDTNVIMW-DPYTGERLRSLHHTQV---DPAMDD 288


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 51/205 (24%), Positives = 87/205 (42%), Gaps = 11/205 (5%)

Query: 470 GIPRHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISHPGNKSPVSQLDCLN 528
           GIP+ A +     H   V  V IS+  +   +G   G +++WD++     +  +    + 
Sbjct: 53  GIPQRALR----GHSHFVSDVVISSDGQFALSGSWDGTLRLWDLT-----TGTTTRRFVG 103

Query: 529 RDNYIRSCKLLPDGCTLIVGGEASTLSIWD-LAAPTPRIKAELTSSAPACYALAISPDSK 587
               + S     D   ++ G    T+ +W+ L      ++ E  S   +C   + +  + 
Sbjct: 104 HTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNP 163

Query: 588 VCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLRE 647
           +  SC  D  + VW+L N  L     GHT   + + +S DG+   +GG D     WDL E
Sbjct: 164 IIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNE 223

Query: 648 GRQLQQHDFTSQIFSLGYCPTGEWL 672
           G+ L   D    I +L + P   WL
Sbjct: 224 GKHLYTLDGGDIINALCFSPNRYWL 248



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 45/180 (25%), Positives = 73/180 (40%), Gaps = 23/180 (12%)

Query: 482 NHGEVVCAVTISNPTRH---VYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKL 538
           +H E V  V  S  + +   V  G    VKVW++++   K+     + +    Y+ +  +
Sbjct: 146 SHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKT-----NHIGHTGYLNTVTV 200

Query: 539 LPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDG-N 597
            PDG     GG+     +WDL         +         AL  SP+    + C + G +
Sbjct: 201 SPDGSLCASGGKDGQAMLWDLNEGKHLYTLD---GGDIINALCFSPNRY--WLCAATGPS 255

Query: 598 IAVWDLHNQTLVRQFQGHTDGAS-------CIDI--SNDGTKLWTGGLDNTVRSWDLREG 648
           I +WDL  + +V + +      S       C  +  S DG  L+ G  DN VR W +  G
Sbjct: 256 IKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 47/194 (24%), Positives = 83/194 (42%), Gaps = 9/194 (4%)

Query: 497 RHVYTGGKGC-VKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLS 555
           R + TGG  C V +W I+ P        +      + + S +L      ++ G ++ ++ 
Sbjct: 34  RLLATGGDDCRVNLWSINKPN-----CIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIR 88

Query: 556 IWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGH 615
           +WDL A   +I   L        +L   P  +   S   D NI +WD+  +  V +++GH
Sbjct: 89  VWDLEAA--KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGH 146

Query: 616 TDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH-DFTSQIFSLGYCPTGEWLAV 674
           +    C+  S DG  L +   D+TV+ WDL  G+ + +    T  +  + + P    LA 
Sbjct: 147 SQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLAS 206

Query: 675 GMESSNVEVLHVNK 688
           G     +    + K
Sbjct: 207 GSSDRTIRFWDLEK 220



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 35/177 (19%), Positives = 77/177 (43%), Gaps = 3/177 (1%)

Query: 595 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ- 653
           D  + +W ++    +    GHT     + ++     +  G    ++R WDL   + L+  
Sbjct: 42  DCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTL 101

Query: 654 HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKW 712
               + I SL + P GE++A G + +N+++  + +    ++   H   V  L+F+  GKW
Sbjct: 102 MGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKW 161

Query: 713 FVSTGKDNLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYEV 768
             S   D+ +  W    G  + +    +  V   +   ++  + +GS D+    +++
Sbjct: 162 LASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 39/170 (22%), Positives = 67/170 (39%), Gaps = 17/170 (10%)

Query: 481 LNHGEVVCAVTISNPTRHVYTGGKGC-VKVWDISHPGNKSPVSQLDCLNR----DNYIRS 535
           + H   +C++        V +G +   +K+WDI   G         C+ R       +R 
Sbjct: 102 MGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG---------CVFRYRGHSQAVRC 152

Query: 536 CKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSD 595
            +  PDG  L    +  T+ +WDL A   ++ +E          +   P+  +  S  SD
Sbjct: 153 LRFSPDGKWLASAADDHTVKLWDLTAG--KMMSEFPGHTGPVNVVEFHPNEYLLASGSSD 210

Query: 596 GNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDN-TVRSWD 644
             I  WDL    +V   +G       +  + DG  L++G  D+  V  W+
Sbjct: 211 RTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 61/276 (22%), Positives = 102/276 (36%), Gaps = 37/276 (13%)

Query: 528 NRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAE------------------ 569
           N +  + + ++ PD   L  G + S + +W L   + ++K+E                  
Sbjct: 266 NTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLR--SKKLKSEPHQVDVSRIHLACDILEE 323

Query: 570 --------------LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGH 615
                         L       Y+     DS    SC  D +I  WDL + T    +QGH
Sbjct: 324 EDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGH 383

Query: 616 TDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQH-DFTSQIFSLGYCPTGEWLAV 674
                 +DIS       +G  D T R W       L+ +    + +  + + P   +LA 
Sbjct: 384 AYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLAT 443

Query: 675 GMESSNVEVLHVNKPDKYQLHL-HESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI 733
           G     V +    + +  +L   H   VLSL F+  GK+  S G+D  L  W    G   
Sbjct: 444 GSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLY 503

Query: 734 FQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 768
            + +  + ++ S   S D   I + S D    V+++
Sbjct: 504 KELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 60/241 (24%), Positives = 95/241 (39%), Gaps = 20/241 (8%)

Query: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592
           + S + L D   L+   E  ++  WDL + T  +  +    A   + L ISP S    S 
Sbjct: 345 VYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQ--GHAYPVWDLDISPYSLYFASG 402

Query: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
             D    +W       +R + GH     C+    +   L TG  D TVR W  ++G  ++
Sbjct: 403 SHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVR 462

Query: 653 QHDFTSQ---IFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKY-QLHLHESCVLSLKFAY 708
              FT     + SL + P G++LA   E   +++  +     Y +L  H   + SL F+ 
Sbjct: 463 L--FTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSP 520

Query: 709 CGKWFVSTGKDNLLNAW--RTPYGASIFQSKES----------SSVLSCDISVDDKYIVT 756
                 S   DN +  W  R  Y ++      S          S+VLS      +  +VT
Sbjct: 521 DSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVT 580

Query: 757 G 757
           G
Sbjct: 581 G 581


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 47/179 (26%), Positives = 81/179 (45%), Gaps = 5/179 (2%)

Query: 595 DGNIAVWDLHNQTLVRQF--QGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
           D  + VW   ++ L  Q+  +GH  G   +DIS+      +  LD  +R WDL  G+Q++
Sbjct: 41  DDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIK 100

Query: 653 QHDF-TSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK-YQLHLHESCVLSLKFAYCG 710
             D      ++L + P  ++LA G     V +  V    K Y L      +LS+ ++  G
Sbjct: 101 SIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDG 160

Query: 711 KWFVSTGKDNLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 768
           K+  S   D ++N +    G  +   +  +  + S   S D + +VT S D    +Y+V
Sbjct: 161 KYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV 219



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 48/200 (24%), Positives = 86/200 (43%), Gaps = 12/200 (6%)

Query: 474 HARQINTLNHGEV-VCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNY 532
           + +QI +++ G V    +  S  ++++ TG      V  ++  G +S   +     R  +
Sbjct: 95  NGKQIKSIDAGPVDAWTLAFSPDSQYLATG----THVGKVNIFGVESGKKEYSLDTRGKF 150

Query: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592
           I S    PDG  L  G     ++I+D+A  T ++   L   A    +L  SPDS++  + 
Sbjct: 151 ILSIAYSPDGKYLASGAIDGIINIFDIA--TGKLLHTLEGHAMPIRSLTFSPDSQLLVTA 208

Query: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
             DG I ++D+ +  L     GH      +    D T   +   D +V+ WD+  G +  
Sbjct: 209 SDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV--GTRTC 266

Query: 653 QH---DFTSQIFSLGYCPTG 669
            H   D   Q++ + Y   G
Sbjct: 267 VHTFFDHQDQVWGVKYNGNG 286



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 38/183 (20%), Positives = 75/183 (40%), Gaps = 22/183 (12%)

Query: 470 GIPRHARQINTLNHGEVVCAVTISNPTRHVYTGG-KGCVKVWDISH-------PGNKSPV 521
           G+    ++ +    G+ + ++  S   +++ +G   G + ++DI+         G+  P 
Sbjct: 134 GVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMP- 192

Query: 522 SQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALA 581
                      IRS    PD   L+   +   + I+D+      +   L+  A     +A
Sbjct: 193 -----------IRSLTFSPDSQLLVTASDDGYIKIYDVQHAN--LAGTLSGHASWVLNVA 239

Query: 582 ISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 641
             PD     S  SD ++ VWD+  +T V  F  H D    +  + +G+K+ + G D  + 
Sbjct: 240 FCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIH 299

Query: 642 SWD 644
            +D
Sbjct: 300 IYD 302


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 42/191 (21%), Positives = 82/191 (42%), Gaps = 8/191 (4%)

Query: 541 DGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAV 600
           D   L+   +  TL IWD+++   +    L   +   +    +P S +  S   D ++ +
Sbjct: 98  DSNLLVSASDDKTLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRI 155

Query: 601 WDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ--HDFTS 658
           WD+     ++    H+D  S +  + DG+ + +   D   R WD   G+ L+    D   
Sbjct: 156 WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNP 215

Query: 659 QIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD---KYQLHLHESCVLSLKFAYCG-KWFV 714
            +  + + P G+++      + +++   +K      Y  H +E   +   F+  G KW V
Sbjct: 216 PVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIV 275

Query: 715 STGKDNLLNAW 725
           S  +DNL+  W
Sbjct: 276 SGSEDNLVYIW 286



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 46/210 (21%), Positives = 84/210 (40%), Gaps = 4/210 (1%)

Query: 562 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASC 621
           P   +K  L     A  ++  SP+ +   S  +D  I +W  ++    +   GH  G S 
Sbjct: 33  PNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD 92

Query: 622 IDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSN 680
           +  S+D   L +   D T++ WD+  G+ L+     ++ +F   + P    +  G    +
Sbjct: 93  VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDES 152

Query: 681 VEVLHVNKPDKYQ-LHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI--FQSK 737
           V +  V      + L  H   V ++ F   G   VS+  D L   W T  G  +      
Sbjct: 153 VRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDD 212

Query: 738 ESSSVLSCDISVDDKYIVTGSGDKKATVYE 767
           ++  V     S + KYI+  + D    +++
Sbjct: 213 DNPPVSFVKFSPNGKYILAATLDNTLKLWD 242



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 47/203 (23%), Positives = 81/203 (39%), Gaps = 13/203 (6%)

Query: 507 VKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRI 566
           +K+WD+S     S           NY+  C   P    ++ G    ++ IWD+   T + 
Sbjct: 111 LKIWDVS-----SGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV--KTGKC 163

Query: 567 KAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWD-LHNQTLVRQFQGHTDGASCIDIS 625
              L + +    A+  + D  +  S   DG   +WD    Q L           S +  S
Sbjct: 164 LKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223

Query: 626 NDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQ----IFSLGYCPTGEWLAVGMESSNV 681
            +G  +    LDNT++ WD  +G+ L+ +         IF+      G+W+  G E + V
Sbjct: 224 PNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLV 283

Query: 682 EVLHVNKPDKYQ-LHLHESCVLS 703
            + ++   +  Q L  H   V+S
Sbjct: 284 YIWNLQTKEIVQKLQGHTDVVIS 306



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 49/243 (20%), Positives = 96/243 (39%), Gaps = 9/243 (3%)

Query: 533 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 592
           + S K  P+G  L        + IW   A   + +  ++        +A S DS +  S 
Sbjct: 48  VSSVKFSPNGEWLASSSADKLIKIW--GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSA 105

Query: 593 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 652
             D  + +WD+ +   ++  +GH++   C + +     + +G  D +VR WD++ G+ L+
Sbjct: 106 SDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLK 165

Query: 653 QHDFTSQ-IFSLGYCPTGEWLAVGMESSNVEVLHVNKPD--KYQLHLHESCVLSLKFAYC 709
                S  + ++ +   G  +          +         K  +      V  +KF+  
Sbjct: 166 TLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPN 225

Query: 710 GKWFVSTGKDNLLNAWRTPYGASI---FQSKESSSVLSCDISV-DDKYIVTGSGDKKATV 765
           GK+ ++   DN L  W    G  +      K     +  + SV   K+IV+GS D    +
Sbjct: 226 GKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYI 285

Query: 766 YEV 768
           + +
Sbjct: 286 WNL 288



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 45/193 (23%), Positives = 75/193 (38%), Gaps = 26/193 (13%)

Query: 494 NPTRHVYTGGK--GCVKVWDISH-------PGNKSPVSQLDCLNRDNYIRSCKLLPDGCT 544
           NP  ++   G     V++WD+         P +  PVS +   NRD           G  
Sbjct: 138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH-FNRD-----------GSL 185

Query: 545 LIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLH 604
           ++         IWD A+    +K  +    P    +  SP+ K   +   D  + +WD  
Sbjct: 186 IVSSSYDGLCRIWDTASGQC-LKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYS 244

Query: 605 NQTLVRQFQGHTDGASCI--DISNDGTK-LWTGGLDNTVRSWDLREGRQLQQ-HDFTSQI 660
               ++ + GH +   CI  + S  G K + +G  DN V  W+L+    +Q+    T  +
Sbjct: 245 KGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVV 304

Query: 661 FSLGYCPTGEWLA 673
            S    PT   +A
Sbjct: 305 ISTACHPTENIIA 317


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.131    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,672,376
Number of Sequences: 37866
Number of extensions: 1987116
Number of successful extensions: 12925
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 244
Number of HSP's successfully gapped in prelim test: 891
Number of HSP's that attempted gapping in prelim test: 8830
Number of HSP's gapped (non-prelim): 4052
length of query: 770
length of database: 18,247,518
effective HSP length: 110
effective length of query: 660
effective length of database: 14,082,258
effective search space: 9294290280
effective search space used: 9294290280
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.