Search of human proteins with 21264363

Search of human proteins with 21264363

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21264363 mannan-binding lectin serine protease 2 isoform 1
precursor [Homo sapiens]
         (686 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21264363 mannan-binding lectin serine protease 2 isoform 1 pr...  1452   0.0  
gi|21264359 mannan-binding lectin serine protease 1 isoform 2 pr...   612   e-175
gi|21264357 mannan-binding lectin serine protease 1 isoform 1 pr...   588   e-168
gi|66347875 complement component 1, r subcomponent [Homo sapiens]     529   e-150
gi|4502495 complement component 1, s subcomponent precursor [Hom...   465   e-131
gi|41393602 complement component 1, s subcomponent precursor [Ho...   465   e-131
gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [H...   390   e-108
gi|21264361 mannan-binding lectin serine protease 2 isoform 2 pr...   390   e-108
gi|7706083 complement component 1, r subcomponent-like precursor...   170   4e-42
gi|11415040 matriptase [Homo sapiens]                                 154   3e-37
gi|110578663 hypothetical protein LOC203074 [Homo sapiens]            151   2e-36
gi|4503649 coagulation factor IX preproprotein [Homo sapiens]         149   1e-35
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom...   148   2e-35
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           148   2e-35
gi|22547221 tolloid-like 1 [Homo sapiens]                             146   5e-35
gi|4826762 haptoglobin isoform 1 preproprotein [Homo sapiens]         144   3e-34
gi|6912724 tolloid-like 2 [Homo sapiens]                              142   1e-33
gi|186910296 haptoglobin isoform 2 preproprotein [Homo sapiens]       141   2e-33
gi|4503625 coagulation factor X preproprotein [Homo sapiens]          141   2e-33
gi|45580723 haptoglobin-related protein [Homo sapiens]                140   4e-33
gi|33695155 hepsin [Homo sapiens]                                     140   5e-33
gi|4504481 hepsin [Homo sapiens]                                      140   5e-33
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom...   139   7e-33
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   135   1e-31
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   135   1e-31
gi|4506115 protein C [Homo sapiens]                                   134   2e-31
gi|10518503 coagulation factor VII isoform b precursor [Homo sap...   134   4e-31
gi|4503645 coagulation factor VII isoform a precursor [Homo sapi...   134   4e-31
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom...   134   4e-31
gi|223942069 enterokinase precursor [Homo sapiens]                    132   8e-31

>gi|21264363 mannan-binding lectin serine protease 2 isoform 1
           precursor [Homo sapiens]
          Length = 686

 Score = 1452 bits (3758), Expect = 0.0
 Identities = 686/686 (100%), Positives = 686/686 (100%)

Query: 1   MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY 60
           MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY
Sbjct: 1   MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY 60

Query: 61  FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD 120
           FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD
Sbjct: 61  FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD 120

Query: 121 YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
           YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC
Sbjct: 121 YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180

Query: 181 SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL 240
           SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL
Sbjct: 181 SALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETL 240

Query: 241 CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC 300
           CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC
Sbjct: 241 CPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC 300

Query: 301 PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA 360
           PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA
Sbjct: 301 PYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPA 360

Query: 361 CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS 420
           CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS
Sbjct: 361 CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTS 420

Query: 421 SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT 480
           SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT
Sbjct: 421 SKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLT 480

Query: 481 AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN 540
           AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN
Sbjct: 481 AAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN 540

Query: 541 KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA 600
           KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA
Sbjct: 541 KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA 600

Query: 601 AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC 660
           AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC
Sbjct: 601 AYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNC 660

Query: 661 GEAGQYGVYTKVINYIPWIENIISDF 686
           GEAGQYGVYTKVINYIPWIENIISDF
Sbjct: 661 GEAGQYGVYTKVINYIPWIENIISDF 686


>gi|21264359 mannan-binding lectin serine protease 1 isoform 2
           precursor [Homo sapiens]
          Length = 728

 Score =  612 bits (1579), Expect = e-175
 Identities = 307/714 (42%), Positives = 431/714 (60%), Gaps = 38/714 (5%)

Query: 1   MRLLTLLGLLCGSVATPLGPKWP-EPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRL 59
           MR L L   LC S++           +FG++ SPG+P  Y +D E  W +T P G+R++L
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 60  YFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRS 119
           YF HF+LE S+LCEYD+VK+ +  +VLAT CG+E+TDTE+ PG++   S GS + ITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 120 DYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRT 179
           D+SNE+ FTGF+A Y A D+DEC+    E  +CDH+CHN++GG+YCSCR GY+LH + RT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 180 CSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPET 239
           C   CS  +FTQR+G ++SP++P PYPK S C Y+I LEEGF V L F + FD+E HPE 
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 240 LCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQP 299
            CPYD++KI+   +  GPFCG+  P  I T+S++V I F +D SG++ GW++ Y +    
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMP 359
           CP    P +G + P QAKY  KD   + C+TGY++L+ ++ + +F   C KDG+W   +P
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 360 ACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTM-KVNDGKYVCEADGFW 418
            C IVDC  P +L  G + + T   +TTYK+ I+YSC+E +Y M   N G Y C A G W
Sbjct: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420

Query: 419 TSSKGEKSLPVCEPVCGLSARTTGG---RIYGGQKAKPGDFPWQVLILGGTTA------- 468
            +    +SLP C P CG  +R+      RI GG+ A+PG FPWQ LI+   T+       
Sbjct: 421 MNKVLGRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKW 480

Query: 469 --AGALLYDNWVLTAAHAVYEQKHDASALDI-RMGTLKRLSPHYTQAWSEA-------VF 518
             +GALL  +W+LTAAH +  Q+ D + + + +      L  H  +  S A       V 
Sbjct: 481 FGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVV 540

Query: 519 IHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQR 578
           +H  + +   +++DIAL++L   V +  ++ P+CLPR E E       +G  +GWG++  
Sbjct: 541 LHPDF-NIQNYNHDIALVQLQEPVPLGPHVMPVCLPRLEPEG-PAPHMLGLVAGWGISNP 598

Query: 579 GF------------LARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGK 626
                         L+  L YV +P+V H +C  +YE       SVT NM CAG   GGK
Sbjct: 599 NVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESRS-GNYSVTENMFCAGYYEGGK 657

Query: 627 DSCRGDSGGALVFLDSETERWFVGGIVSWGS-MNCGEAGQYGVYTKVINYIPWI 679
           D+C GDSGGA V  D  ++RW V G+VSWG    CG    YGVYTKV NY+ W+
Sbjct: 658 DTCLGDSGGAFVIFDDLSQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWV 711


>gi|21264357 mannan-binding lectin serine protease 1 isoform 1
           precursor [Homo sapiens]
          Length = 699

 Score =  588 bits (1516), Expect = e-168
 Identities = 294/702 (41%), Positives = 423/702 (60%), Gaps = 28/702 (3%)

Query: 1   MRLLTLLGLLCGSVATPLGPKWP-EPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRL 59
           MR L L   LC S++           +FG++ SPG+P  Y +D E  W +T P G+R++L
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 60  YFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRS 119
           YF HF+LE S+LCEYD+VK+ +  +VLAT CG+E+TDTE+ PG++   S GS + ITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 120 DYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRT 179
           D+SNE+ FTGF+A Y A D+DEC+    E  +CDH+CHN++GG+YCSCR GY+LH + RT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 180 CSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPET 239
           C   CS  +FTQR+G ++SP++P PYPK S C Y+I LEEGF V L F + FD+E HPE 
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 240 LCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQP 299
            CPYD++KI+   +  GPFCG+  P  I T+S++V I F +D SG++ GW++ Y +    
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMP 359
           CP    P +G + P QAKY  KD   + C+TGY++L+ ++ + +F   C KDG+W   +P
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 360 ACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTM-KVNDGKYVCEADGFW 418
            C IVDC  P +L  G + + T   +TTYK+ I+YSC+E +Y M   N G Y C A G W
Sbjct: 361 TCKIVDCRAPGELEHGLITFSTRNNLTTYKSEIKYSCQEPYYKMLNNNTGIYTCSAQGVW 420

Query: 419 TSSKGEKSLPVCEPVCGLS--ARTTGGRIYGGQKAKPGDFPWQVLIL---GGTTAAGALL 473
            +    +SLP C PVCGL   +R    RI+ G+ A+ G  PW  ++    G     G+LL
Sbjct: 421 MNKVLGRSLPTCLPVCGLPKFSRKLMARIFNGRPAQKGTTPWIAMLSHLNGQPFCGGSLL 480

Query: 474 YDNWVLTAAHAVYE--QKHDASALD---IRMGTLKRLSPHYTQAWSEAVFIHEGYTHDA- 527
             +W++TAAH +++     D +  D   +     K +   + +  S+    H G  H   
Sbjct: 481 GSSWIVTAAHCLHQSLDPEDPTLRDSDLLSPSDFKIILGKHWRLRSDENEQHLGVKHTTL 540

Query: 528 -------GFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGF 580
                   F+ND+AL++L    V+N+ + PICLP    E   +   +   SGWG      
Sbjct: 541 HPQYDPNTFENDVALVELLESPVLNAFVMPICLP----EGPQQEGAMVIVSGWGKQFLQR 596

Query: 581 LARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFL 640
               LM ++IPIVDH  C  AY      +  VT +M+CAG + GGKD+C GDSGG +V L
Sbjct: 597 FPETLMEIEIPIVDHSTCQKAYAP---LKKKVTRDMICAGEKEGGKDACAGDSGGPMVTL 653

Query: 641 DSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENI 682
           + E  +W++ G VSWG  +CG+  +YGVY+ + +   WI+ +
Sbjct: 654 NRERGQWYLVGTVSWGD-DCGKKDRYGVYSYIHHNKDWIQRV 694


>gi|66347875 complement component 1, r subcomponent [Homo sapiens]
          Length = 705

 Score =  529 bits (1362), Expect = e-150
 Identities = 286/688 (41%), Positives = 394/688 (57%), Gaps = 41/688 (5%)

Query: 23  PEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG 82
           P+ +FG + SP FP  Y N+ E    +T P GYR++L F  FDLE S  C YD+VK+S+ 
Sbjct: 22  PQKLFGEVTSPLFPKPYPNNFETTTVITVPTGYRVKLVFQQFDLEPSEGCFYDYVKISAD 81

Query: 83  AKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFT-----GFEAFYAAE 137
            K L   CGQ  +     PGK  F S G+ + +TF +D+SNE+  T     GF A+Y A 
Sbjct: 82  KKSLGRFCGQLGSPLGNPPGKKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAV 141

Query: 138 DIDECQVAP--GEA---PTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQR 192
           D+DEC      GE    P C H CHN++GG++CSCR GY L  ++ +C A CS +++T+ 
Sbjct: 142 DLDECASRSKLGEEDPQPQCQHLCHNYVGGYFCSCRPGYELQEDRHSCQAECSSELYTEA 201

Query: 193 SGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDR 252
           SG +SS EYPR YP    C YSI +E G ++ L F+E FD++ H +  CPYD L+I  + 
Sbjct: 202 SGYISSLEYPRSYPPDLRCNYSIRVERGLTLHLKFLEPFDIDDHQQVHCPYDQLQIYANG 261

Query: 253 EEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPN-GHV 311
           +  G FCGK  P  ++T SN V + F TDESGD  GWK+ YT+    CP P        +
Sbjct: 262 KNIGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLRYTTEIIKCPQPKTLDEFTII 321

Query: 312 SPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDD 371
             +Q +Y  +D F   C+ GY+L++G+  L SFTAVCQ DG+W R MP C I DCG P +
Sbjct: 322 QNLQPQYQFRDYFIATCKQGYQLIEGNQVLHSFTAVCQDDGTWHRAMPRCKIKDCGQPRN 381

Query: 372 LPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKV-------NDGKYVCEADGFWTSSKGE 424
           LP+G   Y T  GV TYKA IQY C E +Y M+          G Y C A G W + +  
Sbjct: 382 LPNGDFRYTTTMGVNTYKARIQYYCHEPYYKMQTRAGSRESEQGVYTCTAQGIWKNEQKG 441

Query: 425 KSLPVCEPVCG--LSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAA 482
           + +P C PVCG  ++      RI GGQKAK G+FPWQV         GALL D W+LTAA
Sbjct: 442 EKIPRCLPVCGKPVNPVEQRQRIIGGQKAKMGNFPWQVFTNIHGRGGGALLGDRWILTAA 501

Query: 483 HAVYEQKHDA---SALDIRMG-----TLKRLSPHYTQAWSEAVFIHEGYTHDA--GFDND 532
           H +Y ++H+A   ++LD+ +G      L +L  H  +     V +H  Y  D    F+ D
Sbjct: 502 HTLYPKEHEAQSNASLDVFLGHTNVEELMKLGNHPIR----RVSVHPDYRQDESYNFEGD 557

Query: 533 IALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPI 592
           IAL++L N V +  N+ PICLP  + ++F     +G  SG+G+ +   +A +L +V +P+
Sbjct: 558 IALLELENSVTLGPNLLPICLP--DNDTFYDLGLMGYVSGFGVMEEK-IAHDLRFVRLPV 614

Query: 593 VDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGI 652
            + Q C   + +        + NM CAG  S  +D+C+GDSGG     D  T+RW   GI
Sbjct: 615 ANPQAC-ENWLRGKNRMDVFSQNMFCAGHPSLKQDACQGDSGGVFAVRDPNTDRWVATGI 673

Query: 653 VSWGSMNCGEAGQYGVYTKVINYIPWIE 680
           VSWG + C     YG YTKV+NY+ WI+
Sbjct: 674 VSWG-IGCSRG--YGFYTKVLNYVDWIK 698


>gi|4502495 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  465 bits (1196), Expect = e-131
 Identities = 264/681 (38%), Positives = 366/681 (53%), Gaps = 42/681 (6%)

Query: 22  WPEP-VFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLS 80
           + EP ++G + SP +P  Y ++ E+ W +  P GY + LYFTH D+ELS  C YD V++ 
Sbjct: 14  YAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQII 73

Query: 81  SGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDID 140
           SG      LCGQ S++   +P  + F    + L + F+SD+SNE+ FTGF A+Y A DI+
Sbjct: 74  SGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDIN 133

Query: 141 ECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPE 200
           EC     + P C H C+N +GG++CSC   Y LH + + C   CSG VFT   GE++SP 
Sbjct: 134 ECTDFV-DVP-CSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPN 191

Query: 201 YPRPYPKLSSCTYSISLEEGFSVILDF-VESFDVETHPETLCPYDFLKIQTDREEHGPFC 259
           YP+PYP+ S C Y I LE+GF V++    E FDVE         D L       + GP+C
Sbjct: 192 YPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYC 251

Query: 260 GKTLPH--RIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAK 317
           G   P    IETKSN + I F TD +G   GWK+ Y     PCP     PN    P +AK
Sbjct: 252 GHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCP-KEDTPNSVWEPAKAK 310

Query: 318 YILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRV 377
           Y+ +D   I C  G+E+++G +   SF + CQ +G W      C  VDCG P+ + +G+V
Sbjct: 311 YVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKV 370

Query: 378 EYITGPGVTTYKAVIQYSCEETFYTMK-VNDGKYVCEADGFWTSSKGEKSLPVCEPVCGL 436
           E    P  T + +VI+Y+CEE +Y M+    G+Y C  +G W +      LP C PVCG+
Sbjct: 371 E---DPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGV 427

Query: 437 SAR--TTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKH---- 490
                    RI GG  A   +FPWQV       A GAL+ + WVLTAAH V   +     
Sbjct: 428 PREPFEEKQRIIGGSDADIKNFPWQV-FFDNPWAGGALINEYWVLTAAHVVEGNREPTMY 486

Query: 491 --DASALDIRMGTLKRLSPHYTQAWSEAVFIHEGY------THDAGFDNDIALIKLNNKV 542
               S    R+   K L+P       E VFIH G+           FDNDIAL++L + V
Sbjct: 487 VGSTSVQTSRLAKSKMLTP-------EHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPV 539

Query: 543 VINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKC-TAA 601
            +   ++PICLP   ++  +   D+G  SGWG T++   A  L    +P+   +KC    
Sbjct: 540 KMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVK 599

Query: 602 YEKPPYPRGS--VTANMLCAGLESGGKDSCRGDSGGALVFLD-SETERWFVGGIVSWGSM 658
            EKP     +   T NM+CAG E  G DSC+GDSGGA    D ++  +++  G+VSWG  
Sbjct: 600 VEKPTADAEAYVFTPNMICAGGEK-GMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGP- 657

Query: 659 NCGEAGQYGVYTKVINYIPWI 679
              + G YG+YT+V NY+ WI
Sbjct: 658 ---QCGTYGLYTRVKNYVDWI 675


>gi|41393602 complement component 1, s subcomponent precursor [Homo
           sapiens]
          Length = 688

 Score =  465 bits (1196), Expect = e-131
 Identities = 264/681 (38%), Positives = 366/681 (53%), Gaps = 42/681 (6%)

Query: 22  WPEP-VFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLS 80
           + EP ++G + SP +P  Y ++ E+ W +  P GY + LYFTH D+ELS  C YD V++ 
Sbjct: 14  YAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIELSENCAYDSVQII 73

Query: 81  SGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDID 140
           SG      LCGQ S++   +P  + F    + L + F+SD+SNE+ FTGF A+Y A DI+
Sbjct: 74  SGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERFTGFAAYYVATDIN 133

Query: 141 ECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPE 200
           EC     + P C H C+N +GG++CSC   Y LH + + C   CSG VFT   GE++SP 
Sbjct: 134 ECTDFV-DVP-CSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVFTALIGEIASPN 191

Query: 201 YPRPYPKLSSCTYSISLEEGFSVILDF-VESFDVETHPETLCPYDFLKIQTDREEHGPFC 259
           YP+PYP+ S C Y I LE+GF V++    E FDVE         D L       + GP+C
Sbjct: 192 YPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVFVAGDRQFGPYC 251

Query: 260 GKTLPH--RIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAK 317
           G   P    IETKSN + I F TD +G   GWK+ Y     PCP     PN    P +AK
Sbjct: 252 GHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCP-KEDTPNSVWEPAKAK 310

Query: 318 YILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGRV 377
           Y+ +D   I C  G+E+++G +   SF + CQ +G W      C  VDCG P+ + +G+V
Sbjct: 311 YVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCGIPESIENGKV 370

Query: 378 EYITGPGVTTYKAVIQYSCEETFYTMK-VNDGKYVCEADGFWTSSKGEKSLPVCEPVCGL 436
           E    P  T + +VI+Y+CEE +Y M+    G+Y C  +G W +      LP C PVCG+
Sbjct: 371 E---DPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPKCVPVCGV 427

Query: 437 SAR--TTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQKH---- 490
                    RI GG  A   +FPWQV       A GAL+ + WVLTAAH V   +     
Sbjct: 428 PREPFEEKQRIIGGSDADIKNFPWQV-FFDNPWAGGALINEYWVLTAAHVVEGNREPTMY 486

Query: 491 --DASALDIRMGTLKRLSPHYTQAWSEAVFIHEGY------THDAGFDNDIALIKLNNKV 542
               S    R+   K L+P       E VFIH G+           FDNDIAL++L + V
Sbjct: 487 VGSTSVQTSRLAKSKMLTP-------EHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPV 539

Query: 543 VINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKC-TAA 601
            +   ++PICLP   ++  +   D+G  SGWG T++   A  L    +P+   +KC    
Sbjct: 540 KMGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVK 599

Query: 602 YEKPPYPRGS--VTANMLCAGLESGGKDSCRGDSGGALVFLD-SETERWFVGGIVSWGSM 658
            EKP     +   T NM+CAG E  G DSC+GDSGGA    D ++  +++  G+VSWG  
Sbjct: 600 VEKPTADAEAYVFTPNMICAGGEK-GMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGP- 657

Query: 659 NCGEAGQYGVYTKVINYIPWI 679
              + G YG+YT+V NY+ WI
Sbjct: 658 ---QCGTYGLYTRVKNYVDWI 675


>gi|73623026 mannan-binding lectin serine protease 1 isoform 3 [Homo
           sapiens]
          Length = 380

 Score =  390 bits (1003), Expect = e-108
 Identities = 176/378 (46%), Positives = 250/378 (66%), Gaps = 1/378 (0%)

Query: 1   MRLLTLLGLLCGSVATPLGPKWP-EPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRL 59
           MR L L   LC S++           +FG++ SPG+P  Y +D E  W +T P G+R++L
Sbjct: 1   MRWLLLYYALCFSLSKASAHTVELNNMFGQIQSPGYPDSYPSDSEVTWNITVPDGFRIKL 60

Query: 60  YFTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRS 119
           YF HF+LE S+LCEYD+VK+ +  +VLAT CG+E+TDTE+ PG++   S GS + ITFRS
Sbjct: 61  YFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSITFRS 120

Query: 120 DYSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRT 179
           D+SNE+ FTGF+A Y A D+DEC+    E  +CDH+CHN++GG+YCSCR GY+LH + RT
Sbjct: 121 DFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRT 180

Query: 180 CSALCSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPET 239
           C   CS  +FTQR+G ++SP++P PYPK S C Y+I LEEGF V L F + FD+E HPE 
Sbjct: 181 CRVECSDNLFTQRTGVITSPDFPNPYPKSSECLYTIELEEGFMVNLQFEDIFDIEDHPEV 240

Query: 240 LCPYDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQP 299
            CPYD++KI+   +  GPFCG+  P  I T+S++V I F +D SG++ GW++ Y +    
Sbjct: 241 PCPYDYIKIKVGPKVLGPFCGEKAPEPISTQSHSVLILFHSDNSGENRGWRLSYRAAGNE 300

Query: 300 CPYPMAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMP 359
           CP    P +G + P QAKY  KD   + C+TGY++L+ ++ + +F   C KDG+W   +P
Sbjct: 301 CPELQPPVHGKIEPSQAKYFFKDQVLVSCDTGYKVLKDNVEMDTFQIECLKDGTWSNKIP 360

Query: 360 ACSIVDCGPPDDLPSGRV 377
            C   +     +L S +V
Sbjct: 361 TCKKNEIDLESELKSEQV 378


>gi|21264361 mannan-binding lectin serine protease 2 isoform 2
           precursor [Homo sapiens]
          Length = 185

 Score =  390 bits (1002), Expect = e-108
 Identities = 181/181 (100%), Positives = 181/181 (100%)

Query: 1   MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY 60
           MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY
Sbjct: 1   MRLLTLLGLLCGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLY 60

Query: 61  FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD 120
           FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD
Sbjct: 61  FTHFDLELSHLCEYDFVKLSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSD 120

Query: 121 YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
           YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC
Sbjct: 121 YSNEKPFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180

Query: 181 S 181
           S
Sbjct: 181 S 181



 Score = 37.7 bits (86), Expect = 0.036
 Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 13/112 (11%)

Query: 194 GELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDRE 253
           G L+SP +P  Y       ++++   G+ + L F   FD+E     LC YDF+K+ +  +
Sbjct: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTH-FDLEL--SHLCEYDFVKLSSGAK 84

Query: 254 EHGPFCGK--TLPHRIETK------SNTVTITFVTDESGD--HTGWKIHYTS 295
                CG+  T   R   K       +++ ITF +D S +   TG++  Y +
Sbjct: 85  VLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAA 136


>gi|7706083 complement component 1, r subcomponent-like precursor
           [Homo sapiens]
          Length = 487

 Score =  170 bits (431), Expect = 4e-42
 Identities = 143/503 (28%), Positives = 211/503 (41%), Gaps = 82/503 (16%)

Query: 195 ELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREE 254
           +L+SP YP PY K    +  I   EGF+V L F + FD+E  P   C  D + I     +
Sbjct: 51  QLTSPGYPEPYGKGQESSTDIKAPEGFAVRLVF-QDFDLE--PSQDCAGDSVTISFVGSD 107

Query: 255 HGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPV 314
              FCG                     + G                  P+  P G    V
Sbjct: 108 PSQFCG---------------------QQGS-----------------PLGRPPGQREFV 129

Query: 315 QAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPS 374
            +   L+ +F    +   E    HL  K F A+ Q              V+   P    S
Sbjct: 130 SSGRSLRLTFRT--QPSSENKTAHLH-KGFLALYQTVA-----------VNYSQPISEAS 175

Query: 375 GRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLPVCEPVC 434
              E I  PG    K  +Q  C+E +Y      G   C   G W   +  + +  C PVC
Sbjct: 176 RGSEAINAPGDNPAK--VQNHCQEPYYQAAAA-GALTCATPGTWKDRQDGEEVLQCMPVC 232

Query: 435 G--LSARTTGGRIYGGQKAKPGDFPWQVLILGGTTAAGALLYDNWVLTAAHAVYEQK--- 489
           G  ++         G  +AK G+FPWQ          GALL D W+LTAAH VY +    
Sbjct: 233 GRPVTPIAQNQTTLGSSRAKLGNFPWQAFTSIHGRGGGALLGDRWILTAAHTVYPKDSVS 292

Query: 490 -HDASALDIRMG-----TLKRLSPHYTQAWSEAVFIHEGYTHDA--GFDNDIALIKLNNK 541
                ++++ +G      + +L  H        V +H  Y  +    F  DIAL++L + 
Sbjct: 293 LRKNQSVNVFLGHTAIDEMLKLGNHPV----HRVVVHPDYRQNESHNFSGDIALLELQHS 348

Query: 542 VVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAA 601
           + +  N+ P+CLP  + E+  R+  +G  SG+G+ + G+L   L Y  +P+   + C A 
Sbjct: 349 IPLGPNVLPVCLP--DNETLYRSGLLGYVSGFGM-EMGWLTTELKYSRLPVAPREACNAW 405

Query: 602 YEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCG 661
            +K   P    + NM C G E+     C+GDSG   V  D+    W   GIVSWG + CG
Sbjct: 406 LQKRQRPE-VFSDNMFCVGDETQRHSVCQGDSGSVYVVWDNHAHHWVATGIVSWG-IGCG 463

Query: 662 EAGQYGVYTKVINYIPWIENIIS 684
           E   Y  YTKV++Y+ WI+ +++
Sbjct: 464 EG--YDFYTKVLSYVDWIKGVMN 484



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 53/159 (33%), Positives = 72/159 (45%), Gaps = 20/159 (12%)

Query: 29  RLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLAT 88
           +L SPG+P  Y   QE    + AP G+ +RL F  FDLE S  C  D V +S      + 
Sbjct: 51  QLTSPGYPEPYGKGQESSTDIKAPEGFAVRLVFQDFDLEPSQDCAGDSVTISFVGSDPSQ 110

Query: 89  LCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKP----FTGFEAFYAAEDIDECQV 144
            CGQ+ +   R PG+  F S G SL +TFR+  S+E        GF A Y    ++  Q 
Sbjct: 111 FCGQQGSPLGRPPGQREFVSSGRSLRLTFRTQPSSENKTAHLHKGFLALYQTVAVNYSQP 170

Query: 145 ------------APGEAPT-CDHHCHNHLGGFYCSCRAG 170
                       APG+ P    +HC      +Y +  AG
Sbjct: 171 ISEASRGSEAINAPGDNPAKVQNHCQE---PYYQAAAAG 206


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  154 bits (388), Expect = 3e-37
 Identities = 141/533 (26%), Positives = 234/533 (43%), Gaps = 58/533 (10%)

Query: 184 CSGQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETH-PETLCP 242
           C G++  +  G  +SP YP  YP    CT++I +     V + F   + +E   P   CP
Sbjct: 340 CGGRL-RKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCP 398

Query: 243 YDFLKIQTDREEHGPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTS--TAQPC 300
            D+++I  ++     +CG+     + + SN +T+ F +D+S   TG+   Y S  ++ PC
Sbjct: 399 KDYVEINGEK-----YCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPC 453

Query: 301 PYPMAPPNGHVSPVQAKYI-------LKDSFSIFCETGYELLQGHLPLKSFTAVCQK--- 350
           P       G     + +           D  +  C+ G++    +   K    VC     
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVND 513

Query: 351 --DGSWDR--PMPA----CSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYT 402
             D S ++    PA    CS   C       +G+ +   G    +   V   +C +  Y 
Sbjct: 514 CGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYR 573

Query: 403 ----MKVNDGKYVCEADGFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPW 458
               + ++ G   C+     +    EK    C+  CGL + T   R+ GG  A  G++PW
Sbjct: 574 CLNGLCLSKGNPECDGKEDCSDGSDEKD---CD--CGLRSFTRQARVVGGTDADEGEWPW 628

Query: 459 QVLI--LG-GTTAAGALLYDNWVLTAAHAVYEQK----HDASALDIRMGT---LKRLSPH 508
           QV +  LG G     +L+  NW+++AAH   + +     D +     +G     +R +P 
Sbjct: 629 QVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPG 688

Query: 509 YTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIG 568
             +   + +  H  + +D  FD DIAL++L      +S + PICLP  +A          
Sbjct: 689 VQERRLKRIISHP-FFNDFTFDYDIALLELEKPAEYSSMVRPICLP--DASHVFPAGKAI 745

Query: 569 TASGWGLTQRGFL-ARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKD 627
             +GWG TQ G   A  L   +I +++   C     +       +T  M+C G  SGG D
Sbjct: 746 WVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQ------QITPRMMCVGFLSGGVD 799

Query: 628 SCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIE 680
           SC+GDSGG L  ++++  R F  G+VSWG   C +  + GVYT++  +  WI+
Sbjct: 800 SCQGDSGGPLSSVEAD-GRIFQAGVVSWGD-GCAQRNKPGVYTRLPLFRDWIK 850



 Score = 38.9 bits (89), Expect = 0.016
 Identities = 45/174 (25%), Positives = 64/174 (36%), Gaps = 36/174 (20%)

Query: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDL----ELSHLCEYDFVKLSSGA 83
           G   SP +PG Y  + +  W +  P    +++ F  F L      +  C  D+V++ +G 
Sbjct: 349 GTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEI-NGE 407

Query: 84  KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAED-IDEC 142
           K     CG+ S           F    +S  IT R         TGF A Y + D  D C
Sbjct: 408 K----YCGERS----------QFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPC 453

Query: 143 QVAPGEAP-----------TCD--HHCHNHLGGFYCSCRAGYVLHRNKRTCSAL 183
              PG+              CD    C +H     CSC AG+      + C  L
Sbjct: 454 ---PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPL 504


>gi|110578663 hypothetical protein LOC203074 [Homo sapiens]
          Length = 352

 Score =  151 bits (382), Expect = 2e-36
 Identities = 92/264 (34%), Positives = 140/264 (53%), Gaps = 23/264 (8%)

Query: 428 PVCEPVCG----LSARTTGGRIYGGQKAKPGDFPWQVLILGGTT--AAGALLYDNWVLTA 481
           PV E  CG       RT   RI GG +A+ G+FPWQV I   +     G++L   W+LTA
Sbjct: 49  PVSE--CGDRSIFEGRTRYSRITGGMEAEVGEFPWQVSIQARSEPFCGGSILNKWWILTA 106

Query: 482 AHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNK 541
           AH +Y ++     L + +GT    SP        ++ +H+ +   A  DNDIAL+ L + 
Sbjct: 107 AHCLYSEELFPEELSVVLGTNDLTSPSMEIKEVASIILHKDFKR-ANMDNDIALLLLASP 165

Query: 542 VVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQ---RGFLARNLMYVDIPIVDHQKC 598
           + ++    PICLP +   +  R   +   +GWG T    +  +  +LM   + I+D ++C
Sbjct: 166 IKLDDLKVPICLPTQPGPATWRECWV---AGWGQTNAADKNSVKTDLMKAPMVIMDWEEC 222

Query: 599 TAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSM 658
           +  + K       +T NMLCAG ++   D+C+GDSGG LV      E+W+  GI+SWG  
Sbjct: 223 SKMFPK-------LTKNMLCAGYKNESYDACKGDSGGPLVCTPEPGEKWYQVGIISWGK- 274

Query: 659 NCGEAGQYGVYTKVINYIPWIENI 682
           +CGE    G+YT ++NY  WIE +
Sbjct: 275 SCGEKNTPGIYTSLVNYNLWIEKV 298


>gi|4503649 coagulation factor IX preproprotein [Homo sapiens]
          Length = 461

 Score =  149 bits (375), Expect = 1e-35
 Identities = 86/243 (35%), Positives = 132/243 (54%), Gaps = 19/243 (7%)

Query: 444 RIYGGQKAKPGDFPWQVLILGGTTA--AGALLYDNWVLTAAHAVYEQKHDASALDIRMGT 501
           R+ GG+ AKPG FPWQV++ G   A   G+++ + W++TAAH V         + +  G 
Sbjct: 226 RVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCV----ETGVKITVVAGE 281

Query: 502 LKRLSPHYTQAWSEAVFIHEGYTHDAG---FDNDIALIKLNNKVVINSNITPICLPRKEA 558
                  +T+     + I   + ++A    +++DIAL++L+  +V+NS +TPIC+  KE 
Sbjct: 282 HNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEY 341

Query: 559 ESFMRTDDIGTASGWG-LTQRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANML 617
            +       G  SGWG +  +G  A  L Y+ +P+VD   C  +       + ++  NM 
Sbjct: 342 TNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRS------TKFTIYNNMF 395

Query: 618 CAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIP 677
           CAG   GG+DSC+GDSGG  V     T   F+ GI+SWG   C   G+YG+YTKV  Y+ 
Sbjct: 396 CAGFHEGGRDSCQGDSGGPHVTEVEGTS--FLTGIISWGE-ECAMKGKYGIYTKVSRYVN 452

Query: 678 WIE 680
           WI+
Sbjct: 453 WIK 455



 Score = 31.6 bits (70), Expect = 2.6
 Identities = 31/112 (27%), Positives = 44/112 (39%), Gaps = 24/112 (21%)

Query: 126 PFTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGG-FYCSCRAGYVLHRNKRTCSALC 184
           PF GFE      D+  C +  G    C+  C N       CSC  GY L  N+++C    
Sbjct: 120 PF-GFEGKNCELDVT-CNIKNGR---CEQFCKNSADNKVVCSCTEGYRLAENQKSC---- 170

Query: 185 SGQVFTQRSGELSSPEYPRPYPKLS-SCTYSISLEEGFSVILDFVESFDVET 235
                         P  P P  ++S S T  ++  E     +D+V S + ET
Sbjct: 171 -------------EPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAET 209


>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
           sapiens]
          Length = 986

 Score =  148 bits (373), Expect = 2e-35
 Identities = 94/293 (32%), Positives = 140/293 (47%), Gaps = 33/293 (11%)

Query: 11  CGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSH 70
           CG   T L         G + SPG+P EY  ++   W L AP  YR+ L F  F+ E + 
Sbjct: 591 CGGFLTKLN--------GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGND 642

Query: 71  LCEYDFVKLSSG----AKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKP 126
           +C+YDFV++ SG    +K+    CG E  +           S  +++ + F+SD +  K 
Sbjct: 643 VCKYDFVEVRSGLTADSKLHGKFCGSEKPEV--------ITSQYNNMRVEFKSDNTVSKK 694

Query: 127 FTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSG 186
             GF+A + + D DEC    G    C   C N  G + C CR+G+VLH NK  C      
Sbjct: 695 --GFKAHFFS-DKDECSKDNGG---CQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCD 748

Query: 187 QVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFL 246
              T  SG ++SP +P  YP    CT++IS   G  V L F+E  D+E+ PE  C YD L
Sbjct: 749 HKVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFME-MDIESQPE--CAYDHL 805

Query: 247 KIQTDREEHGP----FCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTS 295
           ++   R+   P    FCG   P  +    + + + F +D S    G++  + +
Sbjct: 806 EVFDGRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASHAT 858



 Score =  135 bits (341), Expect = 1e-31
 Identities = 86/282 (30%), Positives = 135/282 (47%), Gaps = 25/282 (8%)

Query: 27  FGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVL 86
           +G + SP +P +Y   +   W +    G+ + L F  F++E    C YD++++  G    
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 87  ATL----CGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDEC 142
           +TL    CG E  D  +        S  S L + F SD S  K   GF   +  E +DEC
Sbjct: 503 STLIGRYCGYEKPDDIK--------STSSRLWLKFVSDGSINK--AGFAVNFFKE-VDEC 551

Query: 143 QVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYP 202
              P     C+  C N LG + CSC  GY L  +KR C A C G   T+ +G ++SP +P
Sbjct: 552 S-RPNRG-GCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGG-FLTKLNGSITSPGWP 608

Query: 203 RPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQT----DREEHGPF 258
           + YP   +C + +     + + L F + F  ET    +C YDF+++++    D + HG F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFF--ETEGNDVCKYDFVEVRSGLTADSKLHGKF 665

Query: 259 CGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC 300
           CG   P  I ++ N + + F +D +    G+K H+ S    C
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDEC 707



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 99/398 (24%), Positives = 152/398 (38%), Gaps = 91/398 (22%)

Query: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----A 83
           G  +SP +P  Y+      W ++  PG ++ L FT  DL  S LC YD+V++  G    A
Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390

Query: 84  KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143
            +    CG +  +           S  S L + FRS  S+     GF A Y         
Sbjct: 391 PLRGRFCGSKLPEP--------IVSTDSRLWVEFRS--SSNWVGKGFFAVY--------- 431

Query: 144 VAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPR 203
                                                 A+C G V  +  G + SP YP 
Sbjct: 432 -------------------------------------EAICGGDV-KKDYGHIQSPNYPD 453

Query: 204 PYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEH----GPFC 259
            Y     C + I + EGF V L F +SF++E H    C YD+L+++    E     G +C
Sbjct: 454 DYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDS--CAYDYLEVRDGHSESSTLIGRYC 510

Query: 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYI 319
           G   P  I++ S+ + + FV+D S +  G+ +++      C  P           Q    
Sbjct: 511 GYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP-----NRGGCEQRCLN 565

Query: 320 LKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGR--V 377
              S+   C+ GYEL       +   A C   G +   +   SI   G P + P  +  +
Sbjct: 566 TLGSYKCSCDPGYELAPDK---RRCEAAC---GGFLTKLNG-SITSPGWPKEYPPNKNCI 618

Query: 378 EYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEAD 415
             +  P  T Y+  +Q+   ET       +G  VC+ D
Sbjct: 619 WQLVAP--TQYRISLQFDFFET-------EGNDVCKYD 647



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 69/277 (24%), Positives = 116/277 (41%), Gaps = 64/277 (23%)

Query: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----A 83
           G + SP +P +Y + +E  W +++ PG+R++L F   D+E    C YD +++  G    A
Sbjct: 756 GTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDAKA 815

Query: 84  KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143
            VL   CG +  +   A G   F        + F SD S ++   GF+A +A E   + +
Sbjct: 816 PVLGRFCGSKKPEPVLATGSRMF--------LRFYSDNSVQRK--GFQASHATECGGQVR 865

Query: 144 VAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPR 203
               +  T D + H   G                                          
Sbjct: 866 A---DVKTKDLYSHAQFGD----------------------------------------N 882

Query: 204 PYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGP----FC 259
            YP    C + I  EEG+ V L F ++F+VE   ET C YD++++    +   P    +C
Sbjct: 883 NYPGGVDCEWVIVAEEGYGVELVF-QTFEVEE--ETDCGYDYMELFDGYDSTAPRLGRYC 939

Query: 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTST 296
           G   P  + +  ++V + F +D++    G+ + YTST
Sbjct: 940 GSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTST 976



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 7/97 (7%)

Query: 186 GQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDF 245
           G+     +G  SSPEYP  Y     C + IS+  G  +IL+F     ++ +   LC YD+
Sbjct: 323 GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFT---SLDLYRSRLCWYDY 379

Query: 246 LKIQTDREEHGP----FCGKTLPHRIETKSNTVTITF 278
           ++++       P    FCG  LP  I +  + + + F
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEF 416


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  148 bits (373), Expect = 2e-35
 Identities = 150/515 (29%), Positives = 232/515 (45%), Gaps = 76/515 (14%)

Query: 194 GELSSPEYPRPYPKLSSCTYSI---SLEEGFSVILDFV----ESFDVETHPETLCPYDFL 246
           G LS+P +P  Y   + C++ +   SL+ G ++  D      + +D+       C     
Sbjct: 349 GVLSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLP------CTQGQW 402

Query: 247 KIQTDREEHGPFCGKTL----PHRIETKSNT-VTITFVTDESGDHTGWKIHYT--STAQP 299
            IQ  R      CG  +      RI   +   +TI F +  S    G ++HY   + + P
Sbjct: 403 TIQNRR-----LCGLRILQPYAERIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDP 457

Query: 300 CPYP-MAPPNGHVSPVQAKYILKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPM 358
           CP   +   NG   P  A   +KD     C  G   L     +   T  C++D +     
Sbjct: 458 CPGEFLCSVNGLCVP--ACDGVKD-----CPNG---LDERNCVCRATFQCKEDSTCISLP 507

Query: 359 PACSIVDCGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVN---DGKYVCEAD 415
             C     G PD L +G  E     GV        + CE+     K N   DG+  C  D
Sbjct: 508 KVCD----GQPDCL-NGSDEEQCQEGVPC--GTFTFQCEDRSCVKKPNPQCDGRPDCR-D 559

Query: 416 GFWTSSKGEKSLPVCEPVCGLSARTTGGRIYGGQKAKPGDFPWQ--VLILGGTTAAGALL 473
           G    S  E     C+  CGL   ++  RI GG  +  G++PWQ  + + G     GAL+
Sbjct: 560 G----SDEEH----CD--CGLQGPSS--RIVGGAVSSEGEWPWQASLQVRGRHICGGALI 607

Query: 474 YDNWVLTAAHAVYEQKHDASAL-DIRMGTLKRLS--PHYTQAWSEAVFIHEGYTHDAGFD 530
            D WV+TAAH   E    ++ L  + +G + + S  P         + +H  +  D+  D
Sbjct: 608 ADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDS-HD 666

Query: 531 NDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWG-LTQRGFLARNLMYVD 589
            D+AL++L++ VV ++ + P+CLP +    F         +GWG L + G ++  L  VD
Sbjct: 667 YDVALLQLDHPVVRSAAVRPVCLPARS--HFFEPGLHCWITGWGALREGGPISNALQKVD 724

Query: 590 IPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFV 649
           + ++    C+  Y      R  VT  MLCAG   G KD+C+GDSGG LV   + + RWF+
Sbjct: 725 VQLIPQDLCSEVY------RYQVTPRMLCAGYRKGKKDACQGDSGGPLV-CKALSGRWFL 777

Query: 650 GGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIIS 684
            G+VSWG + CG    +GVYT++   I WI+ +++
Sbjct: 778 AGLVSWG-LGCGRPNYFGVYTRITGVISWIQQVVT 811



 Score = 35.8 bits (81), Expect = 0.14
 Identities = 51/179 (28%), Positives = 67/179 (37%), Gaps = 33/179 (18%)

Query: 28  GRLASPGFPGEYANDQERRWTLTAPP-GYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVL 86
           G L++P FP  Y+      W LT P   Y L L+F  + L      +YD +  + G   +
Sbjct: 349 GVLSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQ---KYD-LPCTQGQWTI 404

Query: 87  AT--LCGQESTD--TERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDEC 142
               LCG        ER P   T     + + I F S  S   P  G    Y     ++ 
Sbjct: 405 QNRRLCGLRILQPYAERIPVVAT-----AGITINFTSQISLTGP--GVRVHYGL--YNQS 455

Query: 143 QVAPGE---------APTCD--HHCHNHLGGFYCSCRAGYVLHRNKRTCSAL---CSGQ 187
              PGE          P CD    C N L    C CRA +   +   TC +L   C GQ
Sbjct: 456 DPCPGEFLCSVNGLCVPACDGVKDCPNGLDERNCVCRATFQC-KEDSTCISLPKVCDGQ 513


>gi|22547221 tolloid-like 1 [Homo sapiens]
          Length = 1013

 Score =  146 bits (369), Expect = 5e-35
 Identities = 94/293 (32%), Positives = 142/293 (48%), Gaps = 33/293 (11%)

Query: 11  CGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSH 70
           CG + T L         G + +PG+P EY  ++   W + AP  YR+ + F  F+LE + 
Sbjct: 618 CGGLLTKLN--------GTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNE 669

Query: 71  LCEYDFVK----LSSGAKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKP 126
           +C+YD+V+    LSS +K+    CG E  +           S  +++ I F+SD +  K 
Sbjct: 670 VCKYDYVEIWSGLSSESKLHGKFCGAEVPEV--------ITSQFNNMRIEFKSDNTVSKK 721

Query: 127 FTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSG 186
             GF+A + + D DEC    G    C H C N +G + C CR G+VLH NK  C      
Sbjct: 722 --GFKAHFFS-DKDECSKDNGG---CQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECE 775

Query: 187 QVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFL 246
           Q     SG ++SP +P  YP    CT+ IS   G  + L F E F++E H E  C YD L
Sbjct: 776 QKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSE-FEIEQHQE--CAYDHL 832

Query: 247 KIQTDREEHGP----FCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTS 295
           ++     E  P     CG  +P  +    N + + FV+D S    G++  +++
Sbjct: 833 EVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATHST 885



 Score =  134 bits (336), Expect = 4e-31
 Identities = 80/281 (28%), Positives = 143/281 (50%), Gaps = 25/281 (8%)

Query: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----A 83
           G++ SP +P +Y   +E  W +T    Y + L F  F++E    C YD++++  G    +
Sbjct: 471 GQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVRDGTSENS 530

Query: 84  KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143
            ++   CG +  +  R        S  ++L + F SD +  K   GF A +  E+ DEC 
Sbjct: 531 PLIGRFCGYDKPEDIR--------STSNTLWMKFVSDGTVNK--AGFAANFFKEE-DEC- 578

Query: 144 VAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPR 203
            A  +   C+  C N LG + C+C  GY L  ++R+C A C G + T+ +G +++P +P+
Sbjct: 579 -AKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGG-LLTKLNGTITTPGWPK 636

Query: 204 PYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKI----QTDREEHGPFC 259
            YP   +C + +     + + + F E F++E +   +C YD+++I     ++ + HG FC
Sbjct: 637 EYPPNKNCVWQVVAPTQYRISVKF-EFFELEGN--EVCKYDYVEIWSGLSSESKLHGKFC 693

Query: 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC 300
           G  +P  I ++ N + I F +D +    G+K H+ S    C
Sbjct: 694 GAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734



 Score =  104 bits (260), Expect = 2e-22
 Identities = 85/315 (26%), Positives = 131/315 (41%), Gaps = 73/315 (23%)

Query: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----A 83
           G L+SPGFP  Y +     W ++  PG ++ L FT  DL  S LC YD++++  G    +
Sbjct: 358 GNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDYIEVRDGYWRKS 417

Query: 84  KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143
            +L   CG      ++ P  +   S  S + I FRS  S+     GF A Y         
Sbjct: 418 PLLGRFCG------DKLP--EVLTSTDSRMWIEFRS--SSNWVGKGFAAVY--------- 458

Query: 144 VAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPR 203
                                                 A+C G++  +  G++ SP YP 
Sbjct: 459 -------------------------------------EAICGGEI-RKNEGQIQSPNYPD 480

Query: 204 PYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGP----FC 259
            Y  +  C + I++ E + V L F +SF++E H    C YD+L+++    E+ P    FC
Sbjct: 481 DYRPMKECVWKITVSESYHVGLTF-QSFEIERHDN--CAYDYLEVRDGTSENSPLIGRFC 537

Query: 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYI 319
           G   P  I + SNT+ + FV+D + +  G+  ++      C     P  G     Q    
Sbjct: 538 GYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDEC---AKPDRGGCE--QRCLN 592

Query: 320 LKDSFSIFCETGYEL 334
              S+   CE GYEL
Sbjct: 593 TLGSYQCACEPGYEL 607



 Score = 76.6 bits (187), Expect = 7e-14
 Identities = 68/280 (24%), Positives = 115/280 (41%), Gaps = 64/280 (22%)

Query: 28   GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----A 83
            G + SP +P +Y + +E  W ++A PG+R++L F+ F++E    C YD +++  G    +
Sbjct: 783  GLITSPNWPDKYPSRKECTWEISATPGHRIKLAFSEFEIEQHQECAYDHLEVFDGETEKS 842

Query: 84   KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143
             +L  LCG +  D   A G   F        + F SD S ++   GF+A ++ E     +
Sbjct: 843  PILGRLCGNKIPDPLVATGNKMF--------VRFVSDASVQRK--GFQATHSTECGGRLK 892

Query: 144  VAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPR 203
                E+   D + H   G                                          
Sbjct: 893  A---ESKPRDLYSHAQFGD----------------------------------------N 909

Query: 204  PYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEH----GPFC 259
             YP    C + +  E G  + L F ++F+VE   +  C YD++++    +      G FC
Sbjct: 910  NYPGQVDCEWLLVSERGSRLELSF-QTFEVEEEAD--CGYDYVELFDGLDSTAVGLGRFC 966

Query: 260  GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQP 299
            G   P  I +  ++V I F TD++ +  G+ I Y S   P
Sbjct: 967  GSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKSIRYP 1006



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 26/97 (26%), Positives = 50/97 (51%), Gaps = 7/97 (7%)

Query: 186 GQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDF 245
           G+   + +G LSSP +P  YP  + C + +S+  G  ++L+F     ++ +  +LC YD+
Sbjct: 350 GETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFT---TMDLYKSSLCWYDY 406

Query: 246 LKIQTDREEHGP----FCGKTLPHRIETKSNTVTITF 278
           ++++       P    FCG  LP  + +  + + I F
Sbjct: 407 IEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEF 443


>gi|4826762 haptoglobin isoform 1 preproprotein [Homo sapiens]
          Length = 406

 Score =  144 bits (363), Expect = 3e-34
 Identities = 100/345 (28%), Positives = 147/345 (42%), Gaps = 39/345 (11%)

Query: 358 MPACSIVD-CGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADG 416
           +P C   D C  P ++  G VE+            ++Y C+  +      DG Y    + 
Sbjct: 83  LPECEADDGCPKPPEIAHGYVEHS-----------VRYQCKNYYKLRTEGDGVYTLNNEK 131

Query: 417 FWTSSKGEKSLPVCEPVCGLSARTTGG--RIYGGQKAKPGDFPWQVLILG--GTTAAGAL 472
            W +      LP CE VCG          RI GG     G FPWQ  ++     T    L
Sbjct: 132 QWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATL 191

Query: 473 LYDNWVLTAAHAVY-EQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDN 531
           + + W+LT A  ++     +A+A DI   TL            E V +H  Y+       
Sbjct: 192 INEQWLLTTAKNLFLNHSENATAKDIAP-TLTLYVGKKQLVEIEKVVLHPNYSQV----- 245

Query: 532 DIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIP 591
           DI LIKL  KV +N  + PICLP K+   +     +G  SGWG         +L YV +P
Sbjct: 246 DIGLIKLKQKVSVNERVMPICLPSKD---YAEVGRVGYVSGWGRNANFKFTDHLKYVMLP 302

Query: 592 IVDHQKCTAAYEKPPYPRGS-----------VTANMLCAGLESGGKDSCRGDSGGALVFL 640
           + D  +C   YE    P              +  +  CAG+    +D+C GD+G A    
Sbjct: 303 VADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVH 362

Query: 641 DSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISD 685
           D E + W+  GI+S+   +C  A +YGVY KV +   W++  I++
Sbjct: 363 DLEEDTWYATGILSF-DKSCAVA-EYGVYVKVTSIQDWVQKTIAE 405


>gi|6912724 tolloid-like 2 [Homo sapiens]
          Length = 1015

 Score =  142 bits (358), Expect = 1e-33
 Identities = 95/293 (32%), Positives = 137/293 (46%), Gaps = 34/293 (11%)

Query: 11  CGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSH 70
           CG   T L         G + SPG+P EY  ++   W + AP  YR+ L F  F+LE + 
Sbjct: 620 CGGFITKLN--------GTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGND 671

Query: 71  LCEYDFVKLSSG----AKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKP 126
           +C+YDFV++ SG    AK+    CG E+ +           S  +++ + F+SD +  K 
Sbjct: 672 VCKYDFVEVRSGLSPDAKLHGRFCGSETPEV--------ITSQSNNMRVEFKSDNTVSK- 722

Query: 127 FTGFEAFYAAEDIDECQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSG 186
             GF A + + D DEC    G    C H C N  G + C CR GY LH N   C      
Sbjct: 723 -RGFRAHFFS-DKDECAKDNGG---CQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCA 777

Query: 187 QVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFL 246
              +   G L+SP +P  YP    CT++IS   G  V L F E F++E H E  C YD L
Sbjct: 778 HKISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNE-FEIEQHQE--CAYDHL 834

Query: 247 KIQTDREEHGP----FCGKTLPHRIETKSNTVTITFVTDESGDHTGWK-IHYT 294
           ++    +   P    FCG   P       +++ + F +D S    G++ +H T
Sbjct: 835 EMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVHST 887



 Score =  139 bits (349), Expect = 1e-32
 Identities = 82/281 (29%), Positives = 142/281 (50%), Gaps = 25/281 (8%)

Query: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----A 83
           G++ SP +P +Y   +E  W +T   G+ + L F  F++E    C YD++++  G    +
Sbjct: 473 GQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEVRDGPTEES 532

Query: 84  KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143
            ++   CG E  +  +        S  + L + F SD S  K   GF A +  E +DEC 
Sbjct: 533 ALIGHFCGYEKPEDVK--------SSSNRLWMKFVSDGSINK--AGFAANFFKE-VDECS 581

Query: 144 VAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPR 203
               +   C+H C N LG + C+C  GY L  +K+ C   C G + T+ +G ++SP +P+
Sbjct: 582 WP--DHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFI-TKLNGTITSPGWPK 638

Query: 204 PYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQT----DREEHGPFC 259
            YP   +C + +     + + L F E F++E +   +C YDF+++++    D + HG FC
Sbjct: 639 EYPTNKNCVWQVVAPAQYRISLQF-EVFELEGN--DVCKYDFVEVRSGLSPDAKLHGRFC 695

Query: 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPC 300
           G   P  I ++SN + + F +D +    G++ H+ S    C
Sbjct: 696 GSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDEC 736



 Score = 99.8 bits (247), Expect = 8e-21
 Identities = 85/312 (27%), Positives = 127/312 (40%), Gaps = 67/312 (21%)

Query: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLA 87
           G  ++PGFP  Y +     W ++  PG ++ L FT  DL  S LC YD+V++  G    A
Sbjct: 360 GNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDYVEVRDGYWRKA 419

Query: 88  TLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQVAPG 147
            L G+   D    P      S  S L + FRS                            
Sbjct: 420 PLLGRFCGDKIPEP----LVSTDSRLWVEFRSS--------------------------- 448

Query: 148 EAPTCDHHCHNHLG-GFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPRPYP 206
                     N LG GF+    A Y          A C G +  + +G++ SP YP  Y 
Sbjct: 449 ---------SNILGKGFF----AAY---------EATCGGDM-NKDAGQIQSPNYPDDYR 485

Query: 207 KLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEH----GPFCGKT 262
               C + I++ EGF V L F ++F++E H    C YD+L+++    E     G FCG  
Sbjct: 486 PSKECVWRITVSEGFHVGLTF-QAFEIERHDS--CAYDYLEVRDGPTEESALIGHFCGYE 542

Query: 263 LPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYILKD 322
            P  +++ SN + + FV+D S +  G+  ++      C +P      H            
Sbjct: 543 KPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWP-----DHGGCEHRCVNTLG 597

Query: 323 SFSIFCETGYEL 334
           S+   C+ GYEL
Sbjct: 598 SYKCACDPGYEL 609



 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 70/279 (25%), Positives = 116/279 (41%), Gaps = 64/279 (22%)

Query: 26   VFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG--- 82
            V G LASP +P +Y + +E  W +++  G+R++L F  F++E    C YD +++  G   
Sbjct: 783  VEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHLEMYDGPDS 842

Query: 83   -AKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDE 141
             A +L   CG +  D   A G        SS+ + F SD S ++   GF+A ++ E    
Sbjct: 843  LAPILGRFCGSKKPDPTVASG--------SSMFLRFYSDASVQRK--GFQAVHSTECGGR 892

Query: 142  CQVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEY 201
             +    E  T + + H   G                                        
Sbjct: 893  LKA---EVQTKELYSHAQFGD--------------------------------------- 910

Query: 202  PRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEHGP---- 257
               YP  + C + I  E+G+ V L F  +F+VE   +  C YD+++     +   P    
Sbjct: 911  -NNYPSEARCDWVIVAEDGYGVELTF-RTFEVEEEAD--CGYDYMEAYDGYDSSAPRLGR 966

Query: 258  FCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTST 296
            FCG      I +  +++ I F TD++ +  G+   YTST
Sbjct: 967  FCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTST 1005



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 27/115 (23%), Positives = 53/115 (46%), Gaps = 7/115 (6%)

Query: 186 GQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDF 245
           G+     +G  S+P +P  YP  S C + IS+  G  ++L+F     ++     LC YD+
Sbjct: 352 GETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFT---SMDLFKSRLCWYDY 408

Query: 246 LKIQTDREEHGP----FCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTST 296
           ++++       P    FCG  +P  + +  + + + F +  +    G+   Y +T
Sbjct: 409 VEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEAT 463


>gi|186910296 haptoglobin isoform 2 preproprotein [Homo sapiens]
          Length = 347

 Score =  141 bits (356), Expect = 2e-33
 Identities = 97/336 (28%), Positives = 143/336 (42%), Gaps = 38/336 (11%)

Query: 366 CGPPDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEK 425
           C  P ++  G VE+            ++Y C+  +      DG Y    +  W +     
Sbjct: 33  CPKPPEIAHGYVEHS-----------VRYQCKNYYKLRTEGDGVYTLNNEKQWINKAVGD 81

Query: 426 SLPVCEPVCGLSARTTGG--RIYGGQKAKPGDFPWQVLILG--GTTAAGALLYDNWVLTA 481
            LP CE VCG          RI GG     G FPWQ  ++     T    L+ + W+LT 
Sbjct: 82  KLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTT 141

Query: 482 AHAVY-EQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNN 540
           A  ++     +A+A DI   TL            E V +H  Y+       DI LIKL  
Sbjct: 142 AKNLFLNHSENATAKDIAP-TLTLYVGKKQLVEIEKVVLHPNYSQV-----DIGLIKLKQ 195

Query: 541 KVVINSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTA 600
           KV +N  + PICLP K+   +     +G  SGWG         +L YV +P+ D  +C  
Sbjct: 196 KVSVNERVMPICLPSKD---YAEVGRVGYVSGWGRNANFKFTDHLKYVMLPVADQDQCIR 252

Query: 601 AYEKPPYPRGS-----------VTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFV 649
            YE    P              +  +  CAG+    +D+C GD+G A    D E + W+ 
Sbjct: 253 HYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFAVHDLEEDTWYA 312

Query: 650 GGIVSWGSMNCGEAGQYGVYTKVINYIPWIENIISD 685
            GI+S+   +C  A +YGVY KV +   W++  I++
Sbjct: 313 TGILSF-DKSCAVA-EYGVYVKVTSIQDWVQKTIAE 346


>gi|4503625 coagulation factor X preproprotein [Homo sapiens]
          Length = 488

 Score =  141 bits (356), Expect = 2e-33
 Identities = 85/244 (34%), Positives = 130/244 (53%), Gaps = 21/244 (8%)

Query: 444 RIYGGQKAKPGDFPWQVLILGGTT---AAGALLYDNWVLTAAHAVYEQKHDASALDIRMG 500
           RI GGQ+ K G+ PWQ L++         G +L + ++LTAAH +Y+ K       +R+G
Sbjct: 234 RIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKR----FKVRVG 289

Query: 501 TLKRLSPHYTQAWSEA--VFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKE- 557
                     +A  E   V  H  +T +  +D DIA+++L   +    N+ P CLP ++ 
Sbjct: 290 DRNTEQEEGGEAVHEVEVVIKHNRFTKET-YDFDIAVLRLKTPITFRMNVAPACLPERDW 348

Query: 558 AESFMRTDDIGTASGWGLT-QRGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANM 616
           AES + T   G  SG+G T ++G  +  L  +++P VD   C  +          +T NM
Sbjct: 349 AESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSF------IITQNM 402

Query: 617 LCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYI 676
            CAG ++  +D+C+GDSGG  V    +T  +FV GIVSWG   C   G+YG+YTKV  ++
Sbjct: 403 FCAGYDTKQEDACQGDSGGPHVTRFKDT--YFVTGIVSWGE-GCARKGKYGIYTKVTAFL 459

Query: 677 PWIE 680
            WI+
Sbjct: 460 KWID 463



 Score = 33.5 bits (75), Expect = 0.67
 Identities = 12/29 (41%), Positives = 13/29 (44%)

Query: 152 CDHHCHNHLGGFYCSCRAGYVLHRNKRTC 180
           CD  CH       CSC  GY L  N + C
Sbjct: 136 CDQFCHEEQNSVVCSCARGYTLADNGKAC 164


>gi|45580723 haptoglobin-related protein [Homo sapiens]
          Length = 348

 Score =  140 bits (353), Expect = 4e-33
 Identities = 97/333 (29%), Positives = 144/333 (43%), Gaps = 38/333 (11%)

Query: 369 PDDLPSGRVEYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEADGFWTSSKGEKSLP 428
           P ++ +G VE++            +Y C+  +      DG Y       W +      LP
Sbjct: 37  PPEIANGYVEHL-----------FRYQCKNYYRLRTEGDGVYTLNDKKQWINKAVGDKLP 85

Query: 429 VCEPVCGLSARTTGG--RIYGGQKAKPGDFPWQVLILG--GTTAAGALLYDNWVLTAAHA 484
            CE VCG          RI GG     G FPWQ  ++     T    L+ + W+LT A  
Sbjct: 86  ECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMVSHHNLTTGATLINEQWLLTTAKN 145

Query: 485 VY-EQKHDASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVV 543
           ++     +A+A DI   TL            E V +H  Y H      DI LIKL  KV+
Sbjct: 146 LFLNHSENATAKDIAP-TLTLYVGKKQLVEIEKVVLHPNY-HQV----DIGLIKLKQKVL 199

Query: 544 INSNITPICLPRKEAESFMRTDDIGTASGWGLTQRGFLARNLMYVDIPIVDHQKCTAAYE 603
           +N  + PICLP K   ++     +G  SGWG +    L  +L YV +P+ D   C   YE
Sbjct: 200 VNERVMPICLPSK---NYAEVGRVGYVSGWGQSDNFKLTDHLKYVMLPVADQYDCITHYE 256

Query: 604 KPPYPRGS-----------VTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGI 652
               P+             +  +  C G+    +D+C GD+G A    D E + W+  GI
Sbjct: 257 GSTCPKWKAPKSPVGVQPILNEHTFCVGMSKYQEDTCYGDAGSAFAVHDLEEDTWYAAGI 316

Query: 653 VSWGSMNCGEAGQYGVYTKVINYIPWIENIISD 685
           +S+   +C  A +YGVY KV +   W++  I++
Sbjct: 317 LSF-DKSCAVA-EYGVYVKVTSIQHWVQKTIAE 347


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  140 bits (352), Expect = 5e-33
 Identities = 93/246 (37%), Positives = 124/246 (50%), Gaps = 17/246 (6%)

Query: 444 RIYGGQKAKPGDFPWQVLIL--GGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGT 501
           RI GG+    G +PWQV +   G     G+LL  +WVLTAAH   E+    S   +  G 
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221

Query: 502 LKRLSPHYTQAWSEAVFIHEGY-----THDAGFDNDIALIKLNNKVVINSNITPICLPRK 556
           + + SPH  Q   +AV  H GY      +     NDIAL+ L++ + +   I P+CLP  
Sbjct: 222 VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP-- 279

Query: 557 EAESFMRTDDIGTASGWGLTQ-RGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTAN 615
            A   +    I T +GWG TQ  G  A  L    +PI+ +  C  A     +    +   
Sbjct: 280 AAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGA----DFYGNQIKPK 335

Query: 616 MLCAGLESGGKDSCRGDSGGALVFLD--SETERWFVGGIVSWGSMNCGEAGQYGVYTKVI 673
           M CAG   GG D+C+GDSGG  V  D  S T RW + GIVSWG+  C  A + GVYTKV 
Sbjct: 336 MFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGT-GCALAQKPGVYTKVS 394

Query: 674 NYIPWI 679
           ++  WI
Sbjct: 395 DFREWI 400


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  140 bits (352), Expect = 5e-33
 Identities = 93/246 (37%), Positives = 124/246 (50%), Gaps = 17/246 (6%)

Query: 444 RIYGGQKAKPGDFPWQVLIL--GGTTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGT 501
           RI GG+    G +PWQV +   G     G+LL  +WVLTAAH   E+    S   +  G 
Sbjct: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221

Query: 502 LKRLSPHYTQAWSEAVFIHEGY-----THDAGFDNDIALIKLNNKVVINSNITPICLPRK 556
           + + SPH  Q   +AV  H GY      +     NDIAL+ L++ + +   I P+CLP  
Sbjct: 222 VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP-- 279

Query: 557 EAESFMRTDDIGTASGWGLTQ-RGFLARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTAN 615
            A   +    I T +GWG TQ  G  A  L    +PI+ +  C  A     +    +   
Sbjct: 280 AAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGA----DFYGNQIKPK 335

Query: 616 MLCAGLESGGKDSCRGDSGGALVFLD--SETERWFVGGIVSWGSMNCGEAGQYGVYTKVI 673
           M CAG   GG D+C+GDSGG  V  D  S T RW + GIVSWG+  C  A + GVYTKV 
Sbjct: 336 MFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGT-GCALAQKPGVYTKVS 394

Query: 674 NYIPWI 679
           ++  WI
Sbjct: 395 DFREWI 400


>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
           sapiens]
          Length = 730

 Score =  139 bits (351), Expect = 7e-33
 Identities = 92/300 (30%), Positives = 144/300 (48%), Gaps = 30/300 (10%)

Query: 27  FGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVL 86
           +G + SP +P +Y   +   W +    G+ + L F  F++E    C YD++++  G    
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 87  ATL----CGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDEC 142
           +TL    CG E  D  +        S  S L + F SD S  K   GF   +  E +DEC
Sbjct: 503 STLIGRYCGYEKPDDIK--------STSSRLWLKFVSDGSINK--AGFAVNFFKE-VDEC 551

Query: 143 QVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYP 202
              P     C+  C N LG + CSC  GY L  +KR C A C G   T+ +G ++SP +P
Sbjct: 552 S-RPNRG-GCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGG-FLTKLNGSITSPGWP 608

Query: 203 RPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQT----DREEHGPF 258
           + YP   +C + +     + + L F + F  ET    +C YDF+++++    D + HG F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFF--ETEGNDVCKYDFVEVRSGLTADSKLHGKF 665

Query: 259 CGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKY 318
           CG   P  I ++ N + + F +D +    G+K H+ S  +P    + PP G   P Q K+
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSEKRPA---LQPPRGR--PHQLKF 720



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 99/398 (24%), Positives = 152/398 (38%), Gaps = 91/398 (22%)

Query: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----A 83
           G  +SP +P  Y+      W ++  PG ++ L FT  DL  S LC YD+V++  G    A
Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390

Query: 84  KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143
            +    CG +          +   S  S L + FRS  S+     GF A Y         
Sbjct: 391 PLRGRFCGSKL--------PEPIVSTDSRLWVEFRS--SSNWVGKGFFAVY--------- 431

Query: 144 VAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPR 203
                                                 A+C G V  +  G + SP YP 
Sbjct: 432 -------------------------------------EAICGGDV-KKDYGHIQSPNYPD 453

Query: 204 PYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEH----GPFC 259
            Y     C + I + EGF V L F +SF++E H    C YD+L+++    E     G +C
Sbjct: 454 DYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDS--CAYDYLEVRDGHSESSTLIGRYC 510

Query: 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYI 319
           G   P  I++ S+ + + FV+D S +  G+ +++      C  P           Q    
Sbjct: 511 GYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP-----NRGGCEQRCLN 565

Query: 320 LKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGR--V 377
              S+   C+ GYEL       +   A C   G +   +   SI   G P + P  +  +
Sbjct: 566 TLGSYKCSCDPGYELAPDK---RRCEAAC---GGFLTKLNG-SITSPGWPKEYPPNKNCI 618

Query: 378 EYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEAD 415
             +  P  T Y+  +Q+   ET       +G  VC+ D
Sbjct: 619 WQLVAP--TQYRISLQFDFFET-------EGNDVCKYD 647



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 41/131 (31%), Positives = 64/131 (48%), Gaps = 22/131 (16%)

Query: 11  CGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSH 70
           CG   T L         G + SPG+P EY  ++   W L AP  YR+ L F  F+ E + 
Sbjct: 591 CGGFLTKLN--------GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGND 642

Query: 71  LCEYDFVKLSSG----AKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKP 126
           +C+YDFV++ SG    +K+    CG E          +   S  +++ + F+SD +  K 
Sbjct: 643 VCKYDFVEVRSGLTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSDNTVSK- 693

Query: 127 FTGFEAFYAAE 137
             GF+A + +E
Sbjct: 694 -KGFKAHFFSE 703



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 7/97 (7%)

Query: 186 GQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDF 245
           G+     +G  SSPEYP  Y     C + IS+  G  +IL+F     ++ +   LC YD+
Sbjct: 323 GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFT---SLDLYRSRLCWYDY 379

Query: 246 LKIQTDREEHGP----FCGKTLPHRIETKSNTVTITF 278
           ++++       P    FCG  LP  I +  + + + F
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEF 416


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  135 bits (341), Expect = 1e-31
 Identities = 92/255 (36%), Positives = 136/255 (53%), Gaps = 24/255 (9%)

Query: 434 CGLSARTTGGRIYGGQKAKPGDFPWQVLILGGT--TAAGALLYDNWVLTAAHAVYEQKHD 491
           CG S +T   R+ GG++A    +PWQV I         G++L  +WVLTAAH  + +  D
Sbjct: 191 CGKSLKTP--RVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHC-FRKHTD 247

Query: 492 ASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPI 551
                +R G+ K L    + A ++ + I     +    DNDIAL+KL   +  +  + PI
Sbjct: 248 VFNWKVRAGSDK-LGSFPSLAVAKIIIIEFNPMYPK--DNDIALMKLQFPLTFSGTVRPI 304

Query: 552 CLPRKEAESFMRTDDIGTASGWGLTQR--GFLARNLMYVDIPIVDHQKCTA--AYEKPPY 607
           CLP  + E    T       GWG T++  G ++  L+   + ++D  +C A  AY+    
Sbjct: 305 CLPFFDEELTPATPL--WIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQ---- 358

Query: 608 PRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYG 667
             G VT  M+CAG+  GG D+C+GDSGG L++   ++++W V GIVSWG   CG     G
Sbjct: 359 --GEVTEKMMCAGIPEGGVDTCQGDSGGPLMY---QSDQWHVVGIVSWG-YGCGGPSTPG 412

Query: 668 VYTKVINYIPWIENI 682
           VYTKV  Y+ WI N+
Sbjct: 413 VYTKVSAYLNWIYNV 427


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  135 bits (341), Expect = 1e-31
 Identities = 92/255 (36%), Positives = 136/255 (53%), Gaps = 24/255 (9%)

Query: 434 CGLSARTTGGRIYGGQKAKPGDFPWQVLILGGT--TAAGALLYDNWVLTAAHAVYEQKHD 491
           CG S +T   R+ GG++A    +PWQV I         G++L  +WVLTAAH  + +  D
Sbjct: 196 CGKSLKTP--RVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHC-FRKHTD 252

Query: 492 ASALDIRMGTLKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPI 551
                +R G+ K L    + A ++ + I     +    DNDIAL+KL   +  +  + PI
Sbjct: 253 VFNWKVRAGSDK-LGSFPSLAVAKIIIIEFNPMYPK--DNDIALMKLQFPLTFSGTVRPI 309

Query: 552 CLPRKEAESFMRTDDIGTASGWGLTQR--GFLARNLMYVDIPIVDHQKCTA--AYEKPPY 607
           CLP  + E    T       GWG T++  G ++  L+   + ++D  +C A  AY+    
Sbjct: 310 CLPFFDEELTPATPL--WIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQ---- 363

Query: 608 PRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQYG 667
             G VT  M+CAG+  GG D+C+GDSGG L++   ++++W V GIVSWG   CG     G
Sbjct: 364 --GEVTEKMMCAGIPEGGVDTCQGDSGGPLMY---QSDQWHVVGIVSWG-YGCGGPSTPG 417

Query: 668 VYTKVINYIPWIENI 682
           VYTKV  Y+ WI N+
Sbjct: 418 VYTKVSAYLNWIYNV 432


>gi|4506115 protein C [Homo sapiens]
          Length = 461

 Score =  134 bits (338), Expect = 2e-31
 Identities = 94/259 (36%), Positives = 132/259 (50%), Gaps = 35/259 (13%)

Query: 444 RIYGGQKAKPGDFPWQVLILGGTT--AAGA-LLYDNWVLTAAHAVYEQKHDASALDIRMG 500
           R+  G+  + GD PWQV++L      A GA L++ +WVLTAAH + E K     L +R+G
Sbjct: 211 RLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKK----LLVRLG 266

Query: 501 T--LKRLSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEA 558
              L+R          + VF+H  Y+     DNDIAL+ L     ++  I PICLP    
Sbjct: 267 EYDLRRWEKWELDLDIKEVFVHPNYSKSTT-DNDIALLHLAQPATLSQTIVPICLP---- 321

Query: 559 ESFMRTDDIGTA------SGWGL--TQRGFLARN----LMYVDIPIVDHQKCTAAYEKPP 606
           +S +   ++  A      +GWG   ++     RN    L ++ IP+V H +C+       
Sbjct: 322 DSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSN-- 379

Query: 607 YPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQY 666
                V+ NMLCAG+    +D+C GDSGG +V     T  WF+ G+VSWG   CG    Y
Sbjct: 380 ----MVSENMLCAGILGDRQDACEGDSGGPMVASFHGT--WFLVGLVSWGE-GCGLLHNY 432

Query: 667 GVYTKVINYIPWIENIISD 685
           GVYTKV  Y+ WI   I D
Sbjct: 433 GVYTKVSRYLDWIHGHIRD 451



 Score = 30.8 bits (68), Expect = 4.4
 Identities = 16/39 (41%), Positives = 21/39 (53%), Gaps = 5/39 (12%)

Query: 138 DIDECQVAPGEAPT----CDHH-CHNHLGGFYCSCRAGY 171
           D D+C V P E P     C H  C + +G F C CR+G+
Sbjct: 88  DGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGW 126


>gi|10518503 coagulation factor VII isoform b precursor [Homo
           sapiens]
          Length = 444

 Score =  134 bits (336), Expect = 4e-31
 Identities = 96/282 (34%), Positives = 139/282 (49%), Gaps = 19/282 (6%)

Query: 415 DGFWTSSKGEKSLPVCEPVCGL-------SARTTGGRIYGGQKAKPGDFPWQVLIL--GG 465
           +G+   + G    P  E  CG        +A    GRI GG+    G+ PWQVL+L  G 
Sbjct: 154 EGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGA 213

Query: 466 TTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVF-IHEGYT 524
               G L+   WV++AAH   + K+  + + + +G    LS H     S  V  +    T
Sbjct: 214 QLCGGTLINTIWVVSAAHCFDKIKNWRNLIAV-LGE-HDLSEHDGDEQSRRVAQVIIPST 271

Query: 525 HDAGFDN-DIALIKLNNKVVINSNITPICLPRKE-AESFMRTDDIGTASGWG-LTQRGFL 581
           +  G  N DIAL++L+  VV+  ++ P+CLP +  +E  +        SGWG L  RG  
Sbjct: 272 YVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGAT 331

Query: 582 ARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLD 641
           A  LM +++P +  Q C     K      ++T  M CAG   G KDSC+GDSGG      
Sbjct: 332 ALELMVLNVPRLMTQDCLQQSRKVG-DSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY 390

Query: 642 SETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENII 683
             T  W++ GIVSWG   C   G +GVYT+V  YI W++ ++
Sbjct: 391 RGT--WYLTGIVSWG-QGCATVGHFGVYTRVSQYIEWLQKLM 429


>gi|4503645 coagulation factor VII isoform a precursor [Homo
           sapiens]
          Length = 466

 Score =  134 bits (336), Expect = 4e-31
 Identities = 96/282 (34%), Positives = 139/282 (49%), Gaps = 19/282 (6%)

Query: 415 DGFWTSSKGEKSLPVCEPVCGL-------SARTTGGRIYGGQKAKPGDFPWQVLIL--GG 465
           +G+   + G    P  E  CG        +A    GRI GG+    G+ PWQVL+L  G 
Sbjct: 176 EGYSLLADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGA 235

Query: 466 TTAAGALLYDNWVLTAAHAVYEQKHDASALDIRMGTLKRLSPHYTQAWSEAVF-IHEGYT 524
               G L+   WV++AAH   + K+  + + + +G    LS H     S  V  +    T
Sbjct: 236 QLCGGTLINTIWVVSAAHCFDKIKNWRNLIAV-LGE-HDLSEHDGDEQSRRVAQVIIPST 293

Query: 525 HDAGFDN-DIALIKLNNKVVINSNITPICLPRKE-AESFMRTDDIGTASGWG-LTQRGFL 581
           +  G  N DIAL++L+  VV+  ++ P+CLP +  +E  +        SGWG L  RG  
Sbjct: 294 YVPGTTNHDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGAT 353

Query: 582 ARNLMYVDIPIVDHQKCTAAYEKPPYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLD 641
           A  LM +++P +  Q C     K      ++T  M CAG   G KDSC+GDSGG      
Sbjct: 354 ALELMVLNVPRLMTQDCLQQSRKVG-DSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHY 412

Query: 642 SETERWFVGGIVSWGSMNCGEAGQYGVYTKVINYIPWIENII 683
             T  W++ GIVSWG   C   G +GVYT+V  YI W++ ++
Sbjct: 413 RGT--WYLTGIVSWG-QGCATVGHFGVYTRVSQYIEWLQKLM 451


>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
           sapiens]
          Length = 823

 Score =  134 bits (336), Expect = 4e-31
 Identities = 85/280 (30%), Positives = 135/280 (48%), Gaps = 25/280 (8%)

Query: 27  FGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVL 86
           +G + SP +P +Y   +   W +    G+ + L F  F++E    C YD++++  G    
Sbjct: 443 YGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDGHSES 502

Query: 87  ATL----CGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDEC 142
           +TL    CG E  D  +        S  S L + F SD S  K   GF   +  E +DEC
Sbjct: 503 STLIGRYCGYEKPDDIK--------STSSRLWLKFVSDGSINK--AGFAVNFFKE-VDEC 551

Query: 143 QVAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYP 202
              P     C+  C N LG + CSC  GY L  +KR C A C G   T+ +G ++SP +P
Sbjct: 552 S-RPNRG-GCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGG-FLTKLNGSITSPGWP 608

Query: 203 RPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQT----DREEHGPF 258
           + YP   +C + +     + + L F + F  ET    +C YDF+++++    D + HG F
Sbjct: 609 KEYPPNKNCIWQLVAPTQYRISLQF-DFF--ETEGNDVCKYDFVEVRSGLTADSKLHGKF 665

Query: 259 CGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQ 298
           CG   P  I ++ N + + F +D +    G+K H+ S  +
Sbjct: 666 CGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLE 705



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 99/398 (24%), Positives = 152/398 (38%), Gaps = 91/398 (22%)

Query: 28  GRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSG----A 83
           G  +SP +P  Y+      W ++  PG ++ L FT  DL  S LC YD+V++  G    A
Sbjct: 331 GNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDYVEVRDGFWRKA 390

Query: 84  KVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPFTGFEAFYAAEDIDECQ 143
            +    CG +  +           S  S L + FRS  S+     GF A Y         
Sbjct: 391 PLRGRFCGSKLPEP--------IVSTDSRLWVEFRS--SSNWVGKGFFAVY--------- 431

Query: 144 VAPGEAPTCDHHCHNHLGGFYCSCRAGYVLHRNKRTCSALCSGQVFTQRSGELSSPEYPR 203
                                                 A+C G V  +  G + SP YP 
Sbjct: 432 -------------------------------------EAICGGDV-KKDYGHIQSPNYPD 453

Query: 204 PYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEH----GPFC 259
            Y     C + I + EGF V L F +SF++E H    C YD+L+++    E     G +C
Sbjct: 454 DYRPSKVCIWRIQVSEGFHVGLTF-QSFEIERHDS--CAYDYLEVRDGHSESSTLIGRYC 510

Query: 260 GKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTSTAQPCPYPMAPPNGHVSPVQAKYI 319
           G   P  I++ S+ + + FV+D S +  G+ +++      C  P           Q    
Sbjct: 511 GYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDECSRP-----NRGGCEQRCLN 565

Query: 320 LKDSFSIFCETGYELLQGHLPLKSFTAVCQKDGSWDRPMPACSIVDCGPPDDLPSGR--V 377
              S+   C+ GYEL       +   A C   G +   +   SI   G P + P  +  +
Sbjct: 566 TLGSYKCSCDPGYELAPDK---RRCEAAC---GGFLTKLNG-SITSPGWPKEYPPNKNCI 618

Query: 378 EYITGPGVTTYKAVIQYSCEETFYTMKVNDGKYVCEAD 415
             +  P  T Y+  +Q+   ET       +G  VC+ D
Sbjct: 619 WQLVAP--TQYRISLQFDFFET-------EGNDVCKYD 647



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 40/128 (31%), Positives = 62/128 (48%), Gaps = 22/128 (17%)

Query: 11  CGSVATPLGPKWPEPVFGRLASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSH 70
           CG   T L         G + SPG+P EY  ++   W L AP  YR+ L F  F+ E + 
Sbjct: 591 CGGFLTKLN--------GSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGND 642

Query: 71  LCEYDFVKLSSG----AKVLATLCGQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKP 126
           +C+YDFV++ SG    +K+    CG E          +   S  +++ + F+SD +  K 
Sbjct: 643 VCKYDFVEVRSGLTADSKLHGKFCGSEK--------PEVITSQYNNMRVEFKSDNTVSK- 693

Query: 127 FTGFEAFY 134
             GF+A +
Sbjct: 694 -KGFKAHF 700



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 28/97 (28%), Positives = 46/97 (47%), Gaps = 7/97 (7%)

Query: 186 GQVFTQRSGELSSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDF 245
           G+     +G  SSPEYP  Y     C + IS+  G  +IL+F     ++ +   LC YD+
Sbjct: 323 GETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFT---SLDLYRSRLCWYDY 379

Query: 246 LKIQTDREEHGP----FCGKTLPHRIETKSNTVTITF 278
           ++++       P    FCG  LP  I +  + + + F
Sbjct: 380 VEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEF 416


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  132 bits (333), Expect = 8e-31
 Identities = 90/258 (34%), Positives = 134/258 (51%), Gaps = 19/258 (7%)

Query: 434  CG--LSARTTGGRIYGGQKAKPGDFPWQV-LILGGTTAAGA-LLYDNWVLTAAHAVYEQK 489
            CG  L+A+    +I GG  AK G +PW V L  GG    GA L+  +W+++AAH VY + 
Sbjct: 772  CGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYGRN 831

Query: 490  HDASALDIRMGTLKR---LSPHYTQAWSEAVFIHEGYTHDAGFDNDIALIKLNNKVVINS 546
             + S     +G   +    SP       + + I+  Y      DNDIA++ L  KV    
Sbjct: 832  LEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHYNRRRK-DNDIAMMHLEFKVNYTD 890

Query: 547  NITPICLPRKEAESFMRTDDIGTASGWG-LTQRGFLARNLMYVDIPIVDHQKCTAAYEKP 605
             I PICLP +E + F    +   A GWG +  +G  A  L   D+P++ +++C     + 
Sbjct: 891  YIQPICLP-EENQVFPPGRNCSIA-GWGTVVYQGTTANILQEADVPLLSNERC-----QQ 943

Query: 606  PYPRGSVTANMLCAGLESGGKDSCRGDSGGALVFLDSETERWFVGGIVSWGSMNCGEAGQ 665
              P  ++T NM+CAG E GG DSC+GDSGG L  +  E  RWF+ G+ S+G   C    +
Sbjct: 944  QMPEYNITENMICAGYEEGGIDSCQGDSGGPL--MCQENNRWFLAGVTSFG-YKCALPNR 1000

Query: 666  YGVYTKVINYIPWIENII 683
             GVY +V  +  WI++ +
Sbjct: 1001 PGVYARVSRFTEWIQSFL 1018



 Score = 33.9 bits (76), Expect = 0.51
 Identities = 24/103 (23%), Positives = 50/103 (48%), Gaps = 11/103 (10%)

Query: 197 SSPEYPRPYPKLSSCTYSISLEEGFSVILDFVESFDVETHPETLCPYDFLKIQTDREEH- 255
           SS  +P  YP L+ C + ++ ++G ++ L F E FD+E         D ++I+   E   
Sbjct: 538 SSTNFPNSYPNLAFCVWILNAQKGKNIQLHFQE-FDLEN------INDVVEIRDGEEADS 590

Query: 256 ---GPFCGKTLPHRIETKSNTVTITFVTDESGDHTGWKIHYTS 295
                + G      + + +N +T+  +T++     G+K ++T+
Sbjct: 591 LLLAVYTGPGPVKDVFSTTNRMTVLLITNDVLARGGFKANFTT 633



 Score = 33.1 bits (74), Expect = 0.88
 Identities = 38/147 (25%), Positives = 52/147 (35%), Gaps = 17/147 (11%)

Query: 31  ASPGFPGEYANDQERRWTLTAPPGYRLRLYFTHFDLELSHLCEYDFVKLSSGAKVLATLC 90
           +S  FP  Y N     W L A  G  ++L+F  FDLE  +    D V++  G +  + L 
Sbjct: 538 SSTNFPNSYPNLAFCVWILNAQKGKNIQLHFQEFDLENIN----DVVEIRDGEEADSLLL 593

Query: 91  GQESTDTERAPGKDTFYSLGSSLDITFRSDYSNEKPF-----TGFEAFYAAE-DIDECQV 144
              +  T   P KD F +      +   +D      F     TG+          D  Q 
Sbjct: 594 ---AVYTGPGPVKDVFSTTNRMTVLLITNDVLARGGFKANFTTGYHLGIPEPCKADHFQC 650

Query: 145 APGE----APTCDHHCHNHLGGFYCSC 167
             GE       CD H H   G     C
Sbjct: 651 KNGECVPLVNLCDGHLHCEDGSDEADC 677


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,025,486
Number of Sequences: 37866
Number of extensions: 1562870
Number of successful extensions: 6308
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 266
Number of HSP's successfully gapped in prelim test: 124
Number of HSP's that attempted gapping in prelim test: 3910
Number of HSP's gapped (non-prelim): 1534
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.