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Search of human proteins with 21237786
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21237786 G protein-coupled receptor kinase interacting
ArfGAP 2 isoform 3 [Homo sapiens]
(679 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21237786 G protein-coupled receptor kinase interacting ArfGAP... 1366 0.0
gi|206725420 G protein-coupled receptor kinase interacting ArfGA... 1359 0.0
gi|206725422 G protein-coupled receptor kinase interacting ArfGA... 1343 0.0
gi|17149830 G protein-coupled receptor kinase interacting ArfGAP... 1327 0.0
gi|17149832 G protein-coupled receptor kinase interacting ArfGAP... 1174 0.0
gi|41393573 G protein-coupled receptor kinase interactor 1 isofo... 851 0.0
gi|146231998 G protein-coupled receptor kinase interactor 1 isof... 848 0.0
gi|206725415 G protein-coupled receptor kinase interacting ArfGA... 838 0.0
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 135 2e-31
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 131 2e-30
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 131 2e-30
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 128 2e-29
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 128 2e-29
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 127 3e-29
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 125 2e-28
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 125 2e-28
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 121 2e-27
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 120 3e-27
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 117 5e-26
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 111 3e-24
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 111 3e-24
gi|7661880 centaurin beta1 [Homo sapiens] 88 3e-17
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 84 4e-16
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 84 4e-16
gi|239755300 PREDICTED: similar to centaurin, gamma-like family,... 80 6e-15
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 80 6e-15
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 80 8e-15
gi|187608516 centaurin, beta 2 [Homo sapiens] 77 5e-14
gi|46094081 development and differentiation enhancing factor 1 [... 72 1e-12
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 71 3e-12
>gi|21237786 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 3 [Homo sapiens]
Length = 679
Score = 1366 bits (3536), Expect = 0.0
Identities = 679/679 (100%), Positives = 679/679 (100%)
Query: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTLQS 420
SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTLQS
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTLQS 420
Query: 421 ENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGE 480
ENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGE
Sbjct: 421 ENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGE 480
Query: 481 ASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGD 540
ASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGD
Sbjct: 481 ASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGD 540
Query: 541 GLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAV 600
GLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAV
Sbjct: 541 GLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAV 600
Query: 601 TEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAY 660
TEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAY
Sbjct: 601 TEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAY 660
Query: 661 DIAKAAKQLVTITTKENNN 679
DIAKAAKQLVTITTKENNN
Sbjct: 661 DIAKAAKQLVTITTKENNN 679
>gi|206725420 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 6 [Homo sapiens]
Length = 681
Score = 1359 bits (3518), Expect = 0.0
Identities = 678/681 (99%), Positives = 678/681 (99%), Gaps = 2/681 (0%)
Query: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGQHFIIPQMADS--SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 298
HKNGQHFIIPQMAD SLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW
Sbjct: 241 HKNGQHFIIPQMADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVW 300
Query: 299 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 358
LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ
Sbjct: 301 LATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQ 360
Query: 359 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL 418
GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL
Sbjct: 361 GSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTL 420
Query: 419 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM 478
QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM
Sbjct: 421 QSENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPM 480
Query: 479 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP 538
GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP
Sbjct: 481 GEASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWP 540
Query: 539 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV 598
GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV
Sbjct: 541 GDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHV 600
Query: 599 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC 658
AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC
Sbjct: 601 AVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQC 660
Query: 659 AYDIAKAAKQLVTITTKENNN 679
AYDIAKAAKQLVTITTKENNN
Sbjct: 661 AYDIAKAAKQLVTITTKENNN 681
>gi|206725422 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 5 [Homo sapiens]
Length = 729
Score = 1343 bits (3475), Expect = 0.0
Identities = 679/729 (93%), Positives = 679/729 (93%), Gaps = 50/729 (6%)
Query: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQ------- 413
SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQ
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL 420
Query: 414 -------------------------------------------KLQTLQSENSNLRKQAT 430
KLQTLQSENSNLRKQAT
Sbjct: 421 SDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQAT 480
Query: 431 TNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMR 490
TNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMR
Sbjct: 481 TNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMR 540
Query: 491 LQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPH 550
LQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPH
Sbjct: 541 LQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPH 600
Query: 551 VAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKK 610
VAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKK
Sbjct: 601 VAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKK 660
Query: 611 PKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLV 670
PKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLV
Sbjct: 661 PKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLV 720
Query: 671 TITTKENNN 679
TITTKENNN
Sbjct: 721 TITTKENNN 729
>gi|17149830 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 1 [Homo sapiens]
Length = 759
Score = 1327 bits (3434), Expect = 0.0
Identities = 679/759 (89%), Positives = 679/759 (89%), Gaps = 80/759 (10%)
Query: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQ------- 413
SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQ
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKSLDSDL 420
Query: 414 -------------------------------------------KLQTLQSENSNLRKQAT 430
KLQTLQSENSNLRKQAT
Sbjct: 421 SDGPVTVQEFMEVKNALVASEAKIQQLMKVNNNLSDELRIMQKKLQTLQSENSNLRKQAT 480
Query: 431 TNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMR 490
TNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMR
Sbjct: 481 TNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEASRPEESRMR 540
Query: 491 LQPFPAH------------------------------ASRLEKQNSTPESDYDNTPNDME 520
LQPFPAH ASRLEKQNSTPESDYDNTPNDME
Sbjct: 541 LQPFPAHIGRSALVTSSSSLPSFPSTLSWSRDESARRASRLEKQNSTPESDYDNTPNDME 600
Query: 521 PDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRA 580
PDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRA
Sbjct: 601 PDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRA 660
Query: 581 AQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPG 640
AQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPG
Sbjct: 661 AQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPG 720
Query: 641 DPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN 679
DPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN
Sbjct: 721 DPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKENNN 759
>gi|17149832 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 2 [Homo sapiens]
Length = 631
Score = 1174 bits (3037), Expect = 0.0
Identities = 604/679 (88%), Positives = 609/679 (89%), Gaps = 48/679 (7%)
Query: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQKLQTLQS 420
SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK S
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK-----S 415
Query: 421 ENSNLRKQATTNVYQVQTGSEYTDTSNHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGE 480
+S+L T VQ E + S K + + SR
Sbjct: 416 LDSDLSDGPVT----VQEFMEVKNALVASEAKIQQLMKASR------------------- 452
Query: 481 ASRPEESRMRLQPFPAHASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGD 540
LEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGD
Sbjct: 453 --------------------LEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGD 492
Query: 541 GLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAV 600
GLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAV
Sbjct: 493 GLVPDTAEPHVAPSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAV 552
Query: 601 TEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAY 660
TEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAY
Sbjct: 553 TEMAALFPKKPKSDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAY 612
Query: 661 DIAKAAKQLVTITTKENNN 679
DIAKAAKQLVTITTKENNN
Sbjct: 613 DIAKAAKQLVTITTKENNN 631
>gi|41393573 G protein-coupled receptor kinase interactor 1 isoform
2 [Homo sapiens]
Length = 761
Score = 851 bits (2198), Expect = 0.0
Identities = 471/776 (60%), Positives = 543/776 (69%), Gaps = 118/776 (15%)
Query: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
Query: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRRE DAVWLA
Sbjct: 241 HKNG-HYIIPQMAD-SLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLA 298
Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
TQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+AKRRQQG
Sbjct: 299 TQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGK 358
Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTASKTNR---- 412
SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+++NR
Sbjct: 359 SLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSM 411
Query: 413 --------------------------QKLQTLQSENSNLR---KQATTNVYQVQT----- 438
K+Q L NS+L ++ ++++Q
Sbjct: 412 DSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQL 471
Query: 439 ----GSEYTDTSNHSSLKRRPSARGS-------RPMSMYETGSGQKPY-LPMGEASRPEE 486
G T + P A G + SMYE GS KP+ P G +E
Sbjct: 472 RQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPG-----DE 526
Query: 487 SRMRLQPF---------------PA-------------------------------HASR 500
RLQPF PA H S+
Sbjct: 527 LTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSK 586
Query: 501 LEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVAPSPTLPST 560
L + S +SDY+NT + G+ +G++ + + P+ P LPST
Sbjct: 587 LSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGDLDPGLPST 642
Query: 561 EDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPKSDMVRTSL 620
EDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P + VR+SL
Sbjct: 643 EDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSL 702
Query: 621 RLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTITTKE 676
RLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTITT+E
Sbjct: 703 RLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTRE 758
>gi|146231998 G protein-coupled receptor kinase interactor 1 isoform
1 [Homo sapiens]
Length = 770
Score = 848 bits (2191), Expect = 0.0
Identities = 471/784 (60%), Positives = 543/784 (69%), Gaps = 125/784 (15%)
Query: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
MS++ +EVCADCS PDP WAS++RG +CDECCSVHRSLGRHIS V+HL+H+ WPPTL
Sbjct: 1 MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTL 60
Query: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
LQMV TL +NGANSIWEHSLLDPA + SGRRKANPQDKVHP K+EFIRAKYQMLAFVH+L
Sbjct: 61 LQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKL 120
Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
PCRDDD VTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKG TPLHVA+KAGQ
Sbjct: 121 PCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQT 180
Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
LQAELL VYGADPG+ D +G+TP+DYARQ GHHELAERLVE QYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGQHFIIPQMAD--------SSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRR 292
HKNG H+IIPQMAD SLDLSELAKAAKKKLQ+LSN LFEELAMDVYDEVDRR
Sbjct: 241 HKNG-HYIIPQMADRSRQKCMSQSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRR 299
Query: 293 ETDAVWLATQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSD 352
E DAVWLATQNHS LVTE + VPFLPVNPEYS+TRNQGRQKLARFNA EFATL+IDILS+
Sbjct: 300 ENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSE 359
Query: 353 AKRRQQGSSLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLE----TTAS 408
AKRRQQG SLS DN+EL L++ +S +DQ DYDSVASDEDTD E T A+
Sbjct: 360 AKRRQQGKSLSSPTDNLELSLRS-------QSDLDDQHDYDSVASDEDTDQEPLRSTGAT 412
Query: 409 KTNR------------------------------QKLQTLQSENSNLR---KQATTNVYQ 435
++NR K+Q L NS+L ++ +++
Sbjct: 413 RSNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHK 472
Query: 436 VQT---------GSEYTDTSNHSSLKRRPSARGS-------RPMSMYETGSGQKPY-LPM 478
+Q G T + P A G + SMYE GS KP+ P
Sbjct: 473 LQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPP 532
Query: 479 GEASRPEESRMRLQPF---------------PA--------------------------- 496
G +E RLQPF PA
Sbjct: 533 G-----DELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQ 587
Query: 497 ----HASRLEKQNSTPESDYDNTPNDMEPDGMGSSRKGRQRSMVWPGDGLVPDTAEPHVA 552
H S+L + S +SDY+NT + G+ +G++ + + P+
Sbjct: 588 EGSRHTSKLSRHGSGADSDYENTQSGDPLLGL----EGKRFLELGKEEDFHPELESLDGD 643
Query: 553 PSPTLPSTEDVIRKTEQITKNIQELLRAAQENKHDSYIPCSERIHVAVTEMAALFPKKPK 612
P LPSTEDVI KTEQ+TKNIQELLRAAQE KHDS++PCSE+IH+AVTEMA+LFPK+P
Sbjct: 644 LDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPA 703
Query: 613 SDMVRTSLRLLTSSAYRLQSECKKTLPGDPGSPTDVQLVTQQVIQCAYDIAKAAKQLVTI 672
+ VR+SLRLL +SAYRLQSEC+KT+P +PG+P D QL+TQQVIQCAYDIAKAAKQLVTI
Sbjct: 704 LEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTI 763
Query: 673 TTKE 676
TT+E
Sbjct: 764 TTRE 767
>gi|206725415 G protein-coupled receptor kinase interacting ArfGAP 2
isoform 4 [Homo sapiens]
Length = 471
Score = 838 bits (2164), Expect = 0.0
Identities = 414/414 (100%), Positives = 414/414 (100%)
Query: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL
Sbjct: 1 MSKRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTL 60
Query: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL
Sbjct: 61 LQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRL 120
Query: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI
Sbjct: 121 PCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQI 180
Query: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD
Sbjct: 181 LQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPD 240
Query: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA
Sbjct: 241 HKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLA 300
Query: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS
Sbjct: 301 TQNHSALVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGS 360
Query: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK 414
SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK
Sbjct: 361 SLSGSKDNVELILKTINNQHSVESQDNDQPDYDSVASDEDTDLETTASKTNRQK 414
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 135 bits (339), Expect = 2e-31
Identities = 78/222 (35%), Positives = 116/222 (52%), Gaps = 17/222 (7%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ +R + C DC P+P WAS+N G +C EC +HR LG H+S+VR L WPP LL
Sbjct: 669 RTVRGNSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLA 728
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
++ + N ANS+WE +L G K P D K +IRAKY+ F+ LP
Sbjct: 729 VMTAMGNALANSVWEGAL-------GGYSKPGP-DACREEKERWIRAKYEQKLFLAPLPS 780
Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANF---FHPEKGNTPLHVASKAGQ 179
D L +QL +V +L + LL+ G++ + G T LH++S
Sbjct: 781 SD------VPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMAN 834
Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ +LL YG D ++D+ G TP+ YAR+ G E A+ L++
Sbjct: 835 VVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQ 876
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 131 bits (329), Expect = 2e-30
Identities = 75/222 (33%), Positives = 115/222 (51%), Gaps = 17/222 (7%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ +R + C DC +P+WAS+N G +C EC +HR+LG H+S+VR L WP L++
Sbjct: 563 RNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIK 622
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
++ ++ N ANS+WE S GR K + D K +IRAKY+ F+ LPC
Sbjct: 623 VMSSIGNELANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC 674
Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 675 ------TELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGN 728
Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ A+LL YG D +D+ G T + YARQ E + L++
Sbjct: 729 VVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 770
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 131 bits (329), Expect = 2e-30
Identities = 75/222 (33%), Positives = 115/222 (51%), Gaps = 17/222 (7%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ +R + C DC +P+WAS+N G +C EC +HR+LG H+S+VR L WP L++
Sbjct: 616 RNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVRSLDLDDWPVELIK 675
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
++ ++ N ANS+WE S GR K + D K +IRAKY+ F+ LPC
Sbjct: 676 VMSSIGNELANSVWEES-------SQGRTKPS-VDSTREEKERWIRAKYEQKLFLAPLPC 727
Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 728 ------TELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGN 781
Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ A+LL YG D +D+ G T + YARQ E + L++
Sbjct: 782 VVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 128 bits (322), Expect = 2e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 938 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 997
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 998 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 1047
Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 1048 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 1103
Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 1104 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 128 bits (322), Expect = 2e-29
Identities = 73/222 (32%), Positives = 120/222 (54%), Gaps = 17/222 (7%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ + + +C DC P+P+WAS+N G +C EC +HR+LG H+S+VR L WP L
Sbjct: 582 RNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTL 641
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
++ + N+ AN +WE S GR K + +D + +IRAKY+ L F+ L
Sbjct: 642 VLTAIGNDTANRVWE-------SDTRGRAKPS-RDSSREERESWIRAKYEQLLFLAPL-- 691
Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLS---LGAQANFFHPEKGNTPLHVASKAGQ 179
S + + L +QL ++V+ ++ T L LL+ G + +PLH+A++
Sbjct: 692 ----STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAH 747
Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ +LL YGAD +D+ G+T + YARQ G A+ L++
Sbjct: 748 VVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 127 bits (319), Expect = 3e-29
Identities = 77/223 (34%), Positives = 118/223 (52%), Gaps = 19/223 (8%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ +R + C DC +P WAS+N G +C EC +HRSLG H+S+VR L+ WP L +
Sbjct: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRK 530
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
++ ++ N+ ANSIWE S + + P +K K +IR+KY+ F+ LP
Sbjct: 531 VMSSIVNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 581
Query: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGA--QANFFHPE-KGNTPLHVASKAG 178
C T L +QL + +L+T + LL+ G+ + N E G T LH+A + G
Sbjct: 582 C------TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKG 635
Query: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 636 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 125 bits (313), Expect = 2e-28
Identities = 77/231 (33%), Positives = 118/231 (51%), Gaps = 21/231 (9%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ +R + C DC +P WAS+N G +C EC +HRSLG +S+VR L+ WP L +
Sbjct: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 507
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
++ ++ N+ ANSIWE S + + P +K K +IR+KY+ F+ LP
Sbjct: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
Query: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178
C T L +QL + +L+T + LL+ G++ G T LH+A + G
Sbjct: 559 C------TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
Query: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDR 229
++ A+LL YG D +D+ G T + YARQ E V +QY D+
Sbjct: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECIN--VLLQYGCPDK 661
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 125 bits (313), Expect = 2e-28
Identities = 75/222 (33%), Positives = 114/222 (51%), Gaps = 17/222 (7%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ +R + C DC +P WAS+N G +C EC +HRSLG +S+VR L+ WP L +
Sbjct: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 507
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
++ ++ N+ ANSIWE S GR K + K +IR+KY+ F+ LPC
Sbjct: 508 VMSSIGNDLANSIWEGS-------SQGRTKPT-EKSTREEKERWIRSKYEEKLFLAPLPC 559
Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
T L +QL + +L+T + LL+ G++ G T LH+A + G
Sbjct: 560 ------TELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 613
Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 614 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 121 bits (304), Expect = 2e-27
Identities = 73/223 (32%), Positives = 114/223 (51%), Gaps = 19/223 (8%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ +R + C DC +P WAS+N G +C EC +H SLG +S+VR L+ WP L +
Sbjct: 448 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRK 507
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKAEFIRAKYQMLAFVHRLP 121
++ ++ N+ ANSIWE S + + P +K K +IR+KY+ F+ LP
Sbjct: 508 VMSSIGNDLANSIWEG---------SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLP 558
Query: 122 CRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAG 178
C T L +QL + +L+T + LL+ G++ G T LH+A + G
Sbjct: 559 C------TELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKG 612
Query: 179 QILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 613 NVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 120 bits (302), Expect = 3e-27
Identities = 73/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ +R + C DC +P WAS+N G +C EC +HRSLG +S+VR L+ WP L +
Sbjct: 335 QNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 394
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
++ ++ N+ ANSIWE S G+ K + + K +IR+KY+ F+ LPC
Sbjct: 395 VMSSIGNDLANSIWEGS-------SQGQTKPS-IESTREEKERWIRSKYEHKLFLAPLPC 446
Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
T L + L + +L T + LL+ G++ G T LH+A + G
Sbjct: 447 ------TELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 500
Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 501 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 117 bits (292), Expect = 5e-26
Identities = 72/222 (32%), Positives = 113/222 (50%), Gaps = 17/222 (7%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ +R + C D +P WAS+N G +C EC +HRSLG +S+VR L+ WP L +
Sbjct: 471 QNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRK 530
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
++ ++ N+ ANSIWE S G+ K + + K +IR+KY+ F+ LPC
Sbjct: 531 VMSSIGNDLANSIWEGS-------SQGQTKPSVK-STREEKERWIRSKYEEKLFLAPLPC 582
Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
T L + L + +L+T + LL+ G++ G T LH+A + G
Sbjct: 583 ------TELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636
Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 637 VVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 111 bits (277), Expect = 3e-24
Identities = 71/222 (31%), Positives = 111/222 (50%), Gaps = 19/222 (8%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ +R + C DC +P WAS+N G +C EC +HRS G +S+VR L+ WP L +
Sbjct: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRK 530
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
++ ++ N ANSIWE S G+ K + + K +IR+KY+ F+ LPC
Sbjct: 531 VMSSIGNELANSIWEGS-------SQGQTKPSIK-STREEKEWWIRSKYEEKLFLAPLPC 582
Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
T L +QL + +L+T + LL+ G++ G T LH+A + G
Sbjct: 583 ------TELSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636
Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ +LL G D +D+ G T + YARQ E L++
Sbjct: 637 VVLEQLL--XGVDVMARDAHGNTALTYARQASSQECINVLLQ 676
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 111 bits (277), Expect = 3e-24
Identities = 71/222 (31%), Positives = 111/222 (50%), Gaps = 19/222 (8%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+ +R + C DC +P WAS+N G +C EC +HRS G +S+VR L+ WP L +
Sbjct: 471 QNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRK 530
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
++ ++ N ANSIWE S G+ K + + K +IR+KY+ F+ LPC
Sbjct: 531 VMSSIGNELANSIWEGS-------SQGQTKPSIK-STREEKEWWIRSKYEEKLFLAPLPC 582
Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFH---PEKGNTPLHVASKAGQ 179
T L +QL + +L+T + LL+ G++ G T LH+A + G
Sbjct: 583 ------TELSLGQQLLRATTDEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGN 636
Query: 180 ILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
++ +LL G D +D+ G T + YARQ E L++
Sbjct: 637 VVLEQLL--XGVDVMARDAHGNTALTYARQASSQECINVLLQ 676
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 87.8 bits (216), Expect = 3e-17
Identities = 83/324 (25%), Positives = 136/324 (41%), Gaps = 57/324 (17%)
Query: 11 CADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNN 70
C DC P P WAS+N G LC +C +HRSLG H S+VR L W P L++++ L N
Sbjct: 420 CCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNV 479
Query: 71 GANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLP--------- 121
N I+E + ++ ++ + Q+ K +I AKY F+ +LP
Sbjct: 480 IINQIYE-ARVEAMAVKKPGPSCSRQE-----KEAWIHAKYVEKKFLTKLPEIRGRRGGR 533
Query: 122 ---------------------CRDDDSVTAKDLSKQLH-------SSVRTGNLETCLRLL 153
R ++DL LH +S +L T L
Sbjct: 534 GRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLG-SLHPGALLFRASGHPPSLPTMADAL 592
Query: 154 SLGAQANFFHPEKGN-TPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGH 212
+ GA N+ + + N TPL A+ A +L E L GA+ DS+G+ P+ +A GH
Sbjct: 593 AHGADVNWVNGGQDNATPLIQATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGH 652
Query: 213 HELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAK-KKLQ 271
LA ++ +L R G+ + M ++ D+ L + AK ++ +
Sbjct: 653 TGLACLFLKRGADLGAR-----------DSEGRDPLTIAMETANADIVTLLRLAKMREAE 701
Query: 272 SLSNHLFEELAMDVYDEVDRRETD 295
+ +E +D++ + +D
Sbjct: 702 AAQGQAGDETYLDIFRDFSLMASD 725
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 84.0 bits (206), Expect = 4e-16
Identities = 61/184 (33%), Positives = 84/184 (45%), Gaps = 25/184 (13%)
Query: 11 CADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLK--HTPWPPTLLQMVETLY 68
CADC P P WAS+N +C C HR LG +S+VR LK W TL+++ L
Sbjct: 305 CADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLG 364
Query: 69 NNGANSIWEHSL-----LDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCR 123
N N W ++ L P+S S RR + AKY+ + P
Sbjct: 365 NGAGNRFWAANVPPSEALQPSSSPSTRRC-------------HLEAKYREGKYRRYHPLF 411
Query: 124 DDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPE-KGNTPLHVASKAGQILQ 182
+ ++L K L ++V T +L LL GA N F + + TPL +A +AGQ LQ
Sbjct: 412 GNQ----EELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQ 467
Query: 183 AELL 186
E L
Sbjct: 468 MEFL 471
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 84.0 bits (206), Expect = 4e-16
Identities = 61/184 (33%), Positives = 84/184 (45%), Gaps = 25/184 (13%)
Query: 11 CADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLK--HTPWPPTLLQMVETLY 68
CADC P P WAS+N +C C HR LG +S+VR LK W TL+++ L
Sbjct: 550 CADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIELFLQLG 609
Query: 69 NNGANSIWEHSL-----LDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCR 123
N N W ++ L P+S S RR + AKY+ + P
Sbjct: 610 NGAGNRFWAANVPPSEALQPSSSPSTRRC-------------HLEAKYREGKYRRYHPLF 656
Query: 124 DDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPE-KGNTPLHVASKAGQILQ 182
+ ++L K L ++V T +L LL GA N F + + TPL +A +AGQ LQ
Sbjct: 657 GNQ----EELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQ 712
Query: 183 AELL 186
E L
Sbjct: 713 MEFL 716
>gi|239755300 PREDICTED: similar to centaurin, gamma-like family,
member 1 [Homo sapiens]
Length = 284
Score = 80.1 bits (196), Expect = 6e-15
Identities = 56/180 (31%), Positives = 89/180 (49%), Gaps = 19/180 (10%)
Query: 46 SQVRHLKHTPWPPTLLQMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDK-VHPNKA 104
S+VR L+ WP L +++ ++ N+ ANSIWE S + + P +K K
Sbjct: 112 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS---------SQGQTKPSEKSTREEKE 162
Query: 105 EFIRAKYQMLAFVHRLPCRDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHP 164
+IR+KY+ F+ LPC D L +QL + +L+T + LL+ G++
Sbjct: 163 RWIRSKYEEKLFLAPLPCTD------LSLGQQLLRATADEDLQTAILLLAHGSREEVNET 216
Query: 165 ---EKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVE 221
G T LH+A + G ++ A+LL YG D +D+ G T + YARQ E L++
Sbjct: 217 CGEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 276
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 80.1 bits (196), Expect = 6e-15
Identities = 43/111 (38%), Positives = 57/111 (51%), Gaps = 6/111 (5%)
Query: 11 CADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNN 70
C DC PDP WAS+N G LC EC +HRSLG H S+VR L W P LL+++ L N+
Sbjct: 418 CGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNS 477
Query: 71 GANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLP 121
N I+E +G RK +K +I+ KY F+ + P
Sbjct: 478 AVNQIYEAQCEG-----AGSRKPTASSS-RQDKEAWIKDKYVEKKFLRKAP 522
Score = 41.2 bits (95), Expect = 0.003
Identities = 24/71 (33%), Positives = 36/71 (50%), Gaps = 1/71 (1%)
Query: 138 HSSVRTGNLETCLRLLSLGAQANFFHPE-KGNTPLHVASKAGQILQAELLAVYGADPGTQ 196
H + R +L L+ GA+ N+ E +G TPL A G ++ E L GAD +
Sbjct: 673 HRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCEFLLQNGADVNQR 732
Query: 197 DSSGKTPVDYA 207
DS G+ P+ +A
Sbjct: 733 DSRGRAPLHHA 743
Score = 34.3 bits (77), Expect = 0.39
Identities = 26/83 (31%), Positives = 36/83 (43%), Gaps = 1/83 (1%)
Query: 137 LHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQ 196
L +V G+L C LL GA N +G PLH A+ G+ Q L GAD
Sbjct: 707 LVQAVLGGSLIVCEFLLQNGADVNQ-RDSRGRAPLHHATLLGRTGQVCLFLKRGADQHAL 765
Query: 197 DSSGKTPVDYARQGGHHELAERL 219
D + P+ A Q + ++ L
Sbjct: 766 DQEQRDPLAIAVQAANADIVTLL 788
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
2 [Homo sapiens]
Length = 1704
Score = 79.7 bits (195), Expect = 8e-15
Identities = 60/183 (32%), Positives = 88/183 (48%), Gaps = 15/183 (8%)
Query: 7 SSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLK--HTPWPPTLLQMV 64
S+ CADC PDP WAS+N +C +C HRSLG S+VR LK + W L+++
Sbjct: 696 SNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELF 755
Query: 65 ETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRD 124
+ N AN W +L + +P +K + FI KY+ F L
Sbjct: 756 IVIGNKRANDFWAGNLQKDEEL----HMDSPVEK----RKNFITQKYKEGKFRKTLLA-- 805
Query: 125 DDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEK-GNTPLHVASKAGQILQA 183
S+T ++L+K L ++V ++ + LL GA + +TP +A KAGQ LQ
Sbjct: 806 --SLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQM 863
Query: 184 ELL 186
E L
Sbjct: 864 EFL 866
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 77.0 bits (188), Expect = 5e-14
Identities = 44/109 (40%), Positives = 58/109 (53%), Gaps = 7/109 (6%)
Query: 11 CADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLYNN 70
C DC DP WAS+N G LC EC +HRSLG H S+VR L W P LL+++ L N+
Sbjct: 414 CCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGND 473
Query: 71 GANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHR 119
N ++E ++ G +K PQ K +IRAKY FV +
Sbjct: 474 VINRVYEANV-----EKMGIKK--PQPGQRQEKEAYIRAKYVERKFVDK 515
Score = 38.1 bits (87), Expect = 0.027
Identities = 30/99 (30%), Positives = 43/99 (43%), Gaps = 3/99 (3%)
Query: 137 LHSSVRTGNLETCLRLLSLGAQANFFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQ 196
L +V G+L TC LL GA N +G PLH A+ G Q L GA+
Sbjct: 645 LIQAVLGGSLVTCEFLLQNGANVNQ-RDVQGRGPLHHATVLGHTGQVCLFLKRGANQHAT 703
Query: 197 DSSGKTPVDYARQGGHHELAE--RLVEIQYELTDRLAFY 233
D GK P+ A + + ++ RL + E+ + Y
Sbjct: 704 DEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEGLY 742
Score = 36.2 bits (82), Expect = 0.10
Identities = 24/78 (30%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 136 QLHSSVRTGNLETCLRLLSLGAQANFFHPEKGN-TPLHVASKAGQILQAELLAVYGADPG 194
QL+ + NL L+ GA N+ + E+ TPL A G ++ E L GA+
Sbjct: 609 QLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVN 668
Query: 195 TQDSSGKTPVDYARQGGH 212
+D G+ P+ +A GH
Sbjct: 669 QRDVQGRGPLHHATVLGH 686
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 72.4 bits (176), Expect = 1e-12
Identities = 56/211 (26%), Positives = 95/211 (45%), Gaps = 20/211 (9%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+RL +++C DC +P+W S N G C EC +HR +G HIS+++ L+ + L
Sbjct: 446 QRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELL 505
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
+ + + NN N I E +L P+ K P + K E+I AKY HR
Sbjct: 506 LAKNVGNNSFNDIMEANLPSPSP------KPTPSSDMTVRK-EYITAKY----VDHRFSR 554
Query: 123 RDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQ--ANFFHP--EKGNTPLHVASKAG 178
+ + +AK +L ++++ +L +++ + G + P E G T LH+A +
Sbjct: 555 KTCSTSSAK--LNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTA 612
Query: 179 QILQAELLAVYGADPGTQDSS---GKTPVDY 206
L+ + G D G T + Y
Sbjct: 613 DQTSLHLVDFLVQNCGNLDKQTALGNTVLHY 643
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 71.2 bits (173), Expect = 3e-12
Identities = 64/254 (25%), Positives = 99/254 (38%), Gaps = 41/254 (16%)
Query: 3 KRLRSSEVCADCSGPDPSWASVNRGTFLCDECCSVHRSLGRHISQVRHLKHTPWPPTLLQ 62
+R+ ++VC DC PDP+W S N G C EC +HR LG H S+++ L + L
Sbjct: 428 QRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELL 487
Query: 63 MVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLAFVHRLPC 122
+ + + N G N I E L S+ K NP ++ K ++I AKY + +
Sbjct: 488 LAKNIGNAGFNEIMECCLPAEDSV-----KPNPGSDMNARK-DYITAKYIERRYARKKHA 541
Query: 123 RDD-------DSVTAKDLSKQLHSSVRTGNL-------------ETCLRLLSLGAQANFF 162
+ ++V +D+ L + +L ET L L
Sbjct: 542 DNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSL 601
Query: 163 H---------------PEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYA 207
H KG+T LH +LL A + SG+TP+D A
Sbjct: 602 HIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIA 661
Query: 208 RQGGHHELAERLVE 221
++ H E L +
Sbjct: 662 KRLKHEHCEELLTQ 675
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.127 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,652,608
Number of Sequences: 37866
Number of extensions: 1257376
Number of successful extensions: 5353
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 284
Number of HSP's successfully gapped in prelim test: 152
Number of HSP's that attempted gapping in prelim test: 3655
Number of HSP's gapped (non-prelim): 1558
length of query: 679
length of database: 18,247,518
effective HSP length: 109
effective length of query: 570
effective length of database: 14,120,124
effective search space: 8048470680
effective search space used: 8048470680
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.