Search of human proteins with 209862855

Search of human proteins with 209862855

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]
         (390 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]       798   0.0  
gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]       798   0.0  
gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]       798   0.0  
gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]       798   0.0  
gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]        798   0.0  
gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]       568   e-162
gi|4507903 vaccinia related kinase 1 [Homo sapiens]                   239   3e-63
gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]        147   2e-35
gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]        147   2e-35
gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]           105   9e-23
gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]           105   9e-23
gi|23199991 casein kinase 1 epsilon [Homo sapiens]                    103   2e-22
gi|4503093 casein kinase 1 epsilon [Homo sapiens]                     103   2e-22
gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]         95   9e-20
gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]          95   9e-20
gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]          95   1e-19
gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]         91   2e-18
gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]          91   2e-18
gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]               90   3e-18
gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]                   89   9e-18
gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]                    88   1e-17
gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]          86   6e-17
gi|58761548 tau tubulin kinase 1 [Homo sapiens]                        83   5e-16
gi|116812624 tau tubulin kinase 2 [Homo sapiens]                       81   1e-15
gi|153945765 mitogen-activated protein kinase kinase kinase 1 [H...    62   9e-10
gi|4826878 oxidative-stress responsive 1 [Homo sapiens]                47   3e-05
gi|42794767 mitogen-activated protein kinase kinase kinase 3 iso...    47   3e-05
gi|42794765 mitogen-activated protein kinase kinase kinase 3 iso...    47   3e-05
gi|115298645 mitogen-activated protein kinase kinase kinase 14 [...    45   1e-04
gi|83776600 aurora kinase B [Homo sapiens]                             45   1e-04

>gi|209862855 vaccinia related kinase 2 isoform 6 [Homo sapiens]
          Length = 390

 Score =  798 bits (2060), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 1   MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 60
           MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN
Sbjct: 1   MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 60

Query: 61  PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 120
           PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY
Sbjct: 61  PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 120

Query: 121 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 180
           CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL
Sbjct: 121 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 180

Query: 181 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 240
           AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR
Sbjct: 181 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 240

Query: 241 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 300
           LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ
Sbjct: 241 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 300

Query: 301 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 360
           KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT
Sbjct: 301 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 360

Query: 361 LSEETNADVYYYRIIIPVLLMLVFLALFFL 390
           LSEETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 361 LSEETNADVYYYRIIIPVLLMLVFLALFFL 390


>gi|194440711 vaccinia related kinase 2 isoform 2 [Homo sapiens]
          Length = 485

 Score =  798 bits (2060), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 1   MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 60
           MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN
Sbjct: 96  MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 155

Query: 61  PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 120
           PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY
Sbjct: 156 PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 215

Query: 121 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 180
           CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL
Sbjct: 216 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 275

Query: 181 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 240
           AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR
Sbjct: 276 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 335

Query: 241 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 300
           LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ
Sbjct: 336 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 395

Query: 301 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 360
           KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT
Sbjct: 396 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 455

Query: 361 LSEETNADVYYYRIIIPVLLMLVFLALFFL 390
           LSEETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 456 LSEETNADVYYYRIIIPVLLMLVFLALFFL 485


>gi|194440709 vaccinia related kinase 2 isoform 1 [Homo sapiens]
          Length = 508

 Score =  798 bits (2060), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 1   MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 60
           MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN
Sbjct: 119 MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 178

Query: 61  PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 120
           PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY
Sbjct: 179 PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 238

Query: 121 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 180
           CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL
Sbjct: 239 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 298

Query: 181 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 240
           AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR
Sbjct: 299 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 358

Query: 241 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 300
           LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ
Sbjct: 359 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 418

Query: 301 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 360
           KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT
Sbjct: 419 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 478

Query: 361 LSEETNADVYYYRIIIPVLLMLVFLALFFL 390
           LSEETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 479 LSEETNADVYYYRIIIPVLLMLVFLALFFL 508


>gi|194440707 vaccinia related kinase 2 isoform 1 [Homo sapiens]
          Length = 508

 Score =  798 bits (2060), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 1   MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 60
           MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN
Sbjct: 119 MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 178

Query: 61  PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 120
           PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY
Sbjct: 179 PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 238

Query: 121 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 180
           CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL
Sbjct: 239 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 298

Query: 181 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 240
           AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR
Sbjct: 299 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 358

Query: 241 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 300
           LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ
Sbjct: 359 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 418

Query: 301 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 360
           KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT
Sbjct: 419 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 478

Query: 361 LSEETNADVYYYRIIIPVLLMLVFLALFFL 390
           LSEETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 479 LSEETNADVYYYRIIIPVLLMLVFLALFFL 508


>gi|71164884 vaccinia related kinase 2 isoform 1 [Homo sapiens]
          Length = 508

 Score =  798 bits (2060), Expect = 0.0
 Identities = 390/390 (100%), Positives = 390/390 (100%)

Query: 1   MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 60
           MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN
Sbjct: 119 MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 178

Query: 61  PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 120
           PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY
Sbjct: 179 PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 238

Query: 121 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 180
           CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL
Sbjct: 239 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 298

Query: 181 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 240
           AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR
Sbjct: 299 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 358

Query: 241 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 300
           LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ
Sbjct: 359 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQESQEPLNEVNSFPQ 418

Query: 301 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 360
           KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT
Sbjct: 419 KISYTQFPNSFYEPHQDFTSPDIFKKSRSPSWYKYTSTVSTGITDLESSTGLWPTISQFT 478

Query: 361 LSEETNADVYYYRIIIPVLLMLVFLALFFL 390
           LSEETNADVYYYRIIIPVLLMLVFLALFFL
Sbjct: 479 LSEETNADVYYYRIIIPVLLMLVFLALFFL 508


>gi|194440713 vaccinia related kinase 2 isoform 3 [Homo sapiens]
          Length = 396

 Score =  568 bits (1463), Expect = e-162
 Identities = 276/276 (100%), Positives = 276/276 (100%)

Query: 1   MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 60
           MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN
Sbjct: 119 MVMERLGIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKN 178

Query: 61  PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 120
           PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY
Sbjct: 179 PDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGY 238

Query: 121 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 180
           CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL
Sbjct: 239 CMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHSL 298

Query: 181 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 240
           AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR
Sbjct: 299 AYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHNR 358

Query: 241 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQ 276
           LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQ
Sbjct: 359 LIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQ 394


>gi|4507903 vaccinia related kinase 1 [Homo sapiens]
          Length = 396

 Score =  239 bits (610), Expect = 3e-63
 Identities = 133/288 (46%), Positives = 174/288 (60%), Gaps = 21/288 (7%)

Query: 1   MVMERLGIDLQKISGQNGT-FKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYK 59
           M+M+R G DLQKI   N   F + TVLQL +R+LD+LEYIHE+EYVHGDIKA+NLLL YK
Sbjct: 129 MIMDRFGSDLQKIYEANAKRFSRKTVLQLSLRILDILEYIHEHEYVHGDIKASNLLLNYK 188

Query: 60  NPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILG 119
           NPDQVYL DYGL+YRYCP G HK+Y+E+P++ H+GTIEFTS+DAH GVA SRR D+EILG
Sbjct: 189 NPDQVYLVDYGLAYRYCPEGVHKEYKEDPKRCHDGTIEFTSIDAHNGVAPSRRGDLEILG 248

Query: 120 YCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAHS 179
           YCM++WL G LPWE NLKDP  V+ +K    + +   + K  P  +   EIA+++     
Sbjct: 249 YCMIQWLTGHLPWEDNLKDPKYVRDSKIRYRENIASLMDKCFPEKNKPGEIAKYMETVKL 308

Query: 180 LAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAATKQVNKAHN 239
           L Y EKP Y+ L+ IL      +G  D      S+         V++     K + K   
Sbjct: 309 LDYTEKPLYENLRDILLQGLKAIGSKDDGKLDLSV---------VENGGLKAKTITKKRK 359

Query: 240 RLIEKKVHSERSAESCATWKVQKEEKLIGLMNNEAAQESTRRRQKYQE 287
           + IE+    E   E       Q E         EA Q  +R R++ Q+
Sbjct: 360 KEIEES--KEPGVEDTEWSNTQTE---------EAIQTRSRTRKRVQK 396


>gi|71164888 vaccinia related kinase 3 isoform 2 [Homo sapiens]
          Length = 424

 Score =  147 bits (371), Expect = 2e-35
 Identities = 81/218 (37%), Positives = 116/218 (53%), Gaps = 14/218 (6%)

Query: 1   MVMERLGIDLQKIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY 58
           +V+  LG  LQ            + +VLQ+  R+LD LE++HENEYVHG++ A N+ +  
Sbjct: 207 LVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDP 266

Query: 59  KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
           ++  QV LA YG ++RYCP+G H  Y E  R  H G +EF S+D HKG   SRRSD++ L
Sbjct: 267 EDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSL 326

Query: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAH 178
           GYCML+WL G LPW   L +   +   K   +D+    V            + ++L    
Sbjct: 327 GYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVM 386

Query: 179 SLAYDEKPNYQALKKIL------------NPHGIPLGP 204
           +L Y+EKP Y  L+  L            +P G+P+ P
Sbjct: 387 ALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP 424


>gi|71164886 vaccinia related kinase 3 isoform 1 [Homo sapiens]
          Length = 474

 Score =  147 bits (371), Expect = 2e-35
 Identities = 81/218 (37%), Positives = 116/218 (53%), Gaps = 14/218 (6%)

Query: 1   MVMERLGIDLQKIS--GQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY 58
           +V+  LG  LQ            + +VLQ+  R+LD LE++HENEYVHG++ A N+ +  
Sbjct: 257 LVLPSLGRSLQSALDVSPKHVLSERSVLQVACRLLDALEFLHENEYVHGNVTAENIFVDP 316

Query: 59  KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
           ++  QV LA YG ++RYCP+G H  Y E  R  H G +EF S+D HKG   SRRSD++ L
Sbjct: 317 EDQSQVTLAGYGFAFRYCPSGKHVAYVEGSRSPHEGDLEFISMDLHKGCGPSRRSDLQSL 376

Query: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAH 178
           GYCML+WL G LPW   L +   +   K   +D+    V            + ++L    
Sbjct: 377 GYCMLKWLYGFLPWTNCLPNTEDIMKQKQKFVDKPGPFVGPCGHWIRPSETLQKYLKVVM 436

Query: 179 SLAYDEKPNYQALKKIL------------NPHGIPLGP 204
           +L Y+EKP Y  L+  L            +P G+P+ P
Sbjct: 437 ALTYEEKPPYAMLRNNLEALLQDLRVSPYDPIGLPMVP 474


>gi|20544145 casein kinase 1, delta isoform 2 [Homo sapiens]
          Length = 409

 Score =  105 bits (261), Expect = 9e-23
 Identities = 69/201 (34%), Positives = 103/201 (51%), Gaps = 15/201 (7%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           MVME LG  L+ +    +  F   TVL L  +M+  +EYIH   ++H D+K  N L+G  
Sbjct: 80  MVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLG 139

Query: 59  KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
           K  + VY+ D+GL+ +Y     H+       K   GT  + S++ H G+  SRR D+E L
Sbjct: 140 KKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESL 199

Query: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQS-----VLKWAPSGSSCCEIAQF 173
           GY ++ +  G LPW Q LK   A +  K   + E   S     + K  PS     E A +
Sbjct: 200 GYVLMYFNLGSLPW-QGLK--AATKRQKYERISEKKMSTPIEVLCKGYPS-----EFATY 251

Query: 174 LVCAHSLAYDEKPNYQALKKI 194
           L    SL +D+KP+Y  L+++
Sbjct: 252 LNFCRSLRFDDKPDYSYLRQL 272


>gi|20149530 casein kinase 1, delta isoform 1 [Homo sapiens]
          Length = 415

 Score =  105 bits (261), Expect = 9e-23
 Identities = 69/201 (34%), Positives = 103/201 (51%), Gaps = 15/201 (7%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           MVME LG  L+ +    +  F   TVL L  +M+  +EYIH   ++H D+K  N L+G  
Sbjct: 80  MVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLG 139

Query: 59  KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
           K  + VY+ D+GL+ +Y     H+       K   GT  + S++ H G+  SRR D+E L
Sbjct: 140 KKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESL 199

Query: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQS-----VLKWAPSGSSCCEIAQF 173
           GY ++ +  G LPW Q LK   A +  K   + E   S     + K  PS     E A +
Sbjct: 200 GYVLMYFNLGSLPW-QGLK--AATKRQKYERISEKKMSTPIEVLCKGYPS-----EFATY 251

Query: 174 LVCAHSLAYDEKPNYQALKKI 194
           L    SL +D+KP+Y  L+++
Sbjct: 252 LNFCRSLRFDDKPDYSYLRQL 272


>gi|23199991 casein kinase 1 epsilon [Homo sapiens]
          Length = 416

 Score =  103 bits (258), Expect = 2e-22
 Identities = 68/201 (33%), Positives = 103/201 (51%), Gaps = 15/201 (7%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           MVME LG  L+ +    +  F   TVL L  +M+  +EYIH   ++H D+K  N L+G  
Sbjct: 80  MVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLG 139

Query: 59  KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
           K  + VY+ D+GL+ +Y     H+       K   GT  + S++ H G+  SRR D+E L
Sbjct: 140 KKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESL 199

Query: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQS-----VLKWAPSGSSCCEIAQF 173
           GY ++ +  G LPW Q LK   A +  K   + E   S     + K  PS     E + +
Sbjct: 200 GYVLMYFNLGSLPW-QGLK--AATKRQKYERISEKKMSTPIEVLCKGYPS-----EFSTY 251

Query: 174 LVCAHSLAYDEKPNYQALKKI 194
           L    SL +D+KP+Y  L+++
Sbjct: 252 LNFCRSLRFDDKPDYSYLRQL 272


>gi|4503093 casein kinase 1 epsilon [Homo sapiens]
          Length = 416

 Score =  103 bits (258), Expect = 2e-22
 Identities = 68/201 (33%), Positives = 103/201 (51%), Gaps = 15/201 (7%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           MVME LG  L+ +    +  F   TVL L  +M+  +EYIH   ++H D+K  N L+G  
Sbjct: 80  MVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLG 139

Query: 59  KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
           K  + VY+ D+GL+ +Y     H+       K   GT  + S++ H G+  SRR D+E L
Sbjct: 140 KKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESL 199

Query: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQS-----VLKWAPSGSSCCEIAQF 173
           GY ++ +  G LPW Q LK   A +  K   + E   S     + K  PS     E + +
Sbjct: 200 GYVLMYFNLGSLPW-QGLK--AATKRQKYERISEKKMSTPIEVLCKGYPS-----EFSTY 251

Query: 174 LVCAHSLAYDEKPNYQALKKI 194
           L    SL +D+KP+Y  L+++
Sbjct: 252 LNFCRSLRFDDKPDYSYLRQL 272


>gi|113462010 casein kinase 1, gamma 3 isoform 4 [Homo sapiens]
          Length = 455

 Score = 95.1 bits (235), Expect = 9e-20
 Identities = 75/272 (27%), Positives = 117/272 (43%), Gaps = 21/272 (7%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           MV+E LG  L+ +    + TF   TVL + I+++  +EY+H    ++ D+K  N L+G  
Sbjct: 114 MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRP 173

Query: 59  --KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVE 116
             K    +++ D+GL+  Y      K       K   GT  + S++ H G   SRR D+E
Sbjct: 174 GNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLE 233

Query: 117 ILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EI 170
            LG+  + +L G LPW          Q  K + L E  Q +   K A      C    E+
Sbjct: 234 ALGHMFMYFLRGSLPW----------QGLKADTLKERYQKIGDTKRATPIEVLCENFPEM 283

Query: 171 AQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAA 230
           A +L     L + EKP+Y  L+K+        G + F  +   I    P       Q  A
Sbjct: 284 ATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPA 342

Query: 231 TKQVNKAHNRLIEKKVHSERSAESCATWKVQK 262
                +AH    + +    +SA+  A W  Q+
Sbjct: 343 LSSNREAHQHRDKMQQSKNQSADHRAAWDSQQ 374


>gi|73532778 casein kinase 1, gamma 3 isoform 1 [Homo sapiens]
          Length = 447

 Score = 95.1 bits (235), Expect = 9e-20
 Identities = 75/272 (27%), Positives = 117/272 (43%), Gaps = 21/272 (7%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           MV+E LG  L+ +    + TF   TVL + I+++  +EY+H    ++ D+K  N L+G  
Sbjct: 114 MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRP 173

Query: 59  --KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVE 116
             K    +++ D+GL+  Y      K       K   GT  + S++ H G   SRR D+E
Sbjct: 174 GNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLE 233

Query: 117 ILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EI 170
            LG+  + +L G LPW          Q  K + L E  Q +   K A      C    E+
Sbjct: 234 ALGHMFMYFLRGSLPW----------QGLKADTLKERYQKIGDTKRATPIEVLCENFPEM 283

Query: 171 AQFLVCAHSLAYDEKPNYQALKKILNPHGIPLGPLDFSTKGQSINVHTPNSQKVDSQKAA 230
           A +L     L + EKP+Y  L+K+        G + F  +   I    P       Q  A
Sbjct: 284 ATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRKGYM-FDYEYDWIGKQLPTPVGAVQQDPA 342

Query: 231 TKQVNKAHNRLIEKKVHSERSAESCATWKVQK 262
                +AH    + +    +SA+  A W  Q+
Sbjct: 343 LSSNREAHQHRDKMQQSKNQSADHRAAWDSQQ 374


>gi|68303572 casein kinase 1, alpha 1 isoform 2 [Homo sapiens]
          Length = 337

 Score = 94.7 bits (234), Expect = 1e-19
 Identities = 60/196 (30%), Positives = 99/196 (50%), Gaps = 5/196 (2%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           +VM+ LG  L+ +    +  F   TVL L  +M+  +EY+H   ++H DIK  N L+G  
Sbjct: 88  LVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIG 147

Query: 59  KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
           ++ ++++L D+GL+ +Y  N   +       K   GT  + S++AH G+  SRR D+E L
Sbjct: 148 RHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESL 207

Query: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAH 178
           GY ++ +    LPW Q LK   A +  K   + E   S            E A +L    
Sbjct: 208 GYVLMYFNRTSLPW-QGLK--AATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCR 264

Query: 179 SLAYDEKPNYQALKKI 194
            L ++E P+Y  L+++
Sbjct: 265 GLRFEEAPDYMYLRQL 280


>gi|113462008 casein kinase 1, gamma 3 isoform 3 [Homo sapiens]
          Length = 415

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 62/204 (30%), Positives = 96/204 (47%), Gaps = 20/204 (9%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           MV+E LG  L+ +    + TF   TVL + I+++  +EY+H    ++ D+K  N L+G  
Sbjct: 114 MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRP 173

Query: 59  --KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVE 116
             K    +++ D+GL+  Y      K       K   GT  + S++ H G   SRR D+E
Sbjct: 174 GNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLE 233

Query: 117 ILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EI 170
            LG+  + +L G LPW          Q  K + L E  Q +   K A      C    E+
Sbjct: 234 ALGHMFMYFLRGSLPW----------QGLKADTLKERYQKIGDTKRATPIEVLCENFPEM 283

Query: 171 AQFLVCAHSLAYDEKPNYQALKKI 194
           A +L     L + EKP+Y  L+K+
Sbjct: 284 ATYLRYVRRLDFFEKPDYDYLRKL 307


>gi|73532780 casein kinase 1, gamma 3 isoform 2 [Homo sapiens]
          Length = 423

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 62/204 (30%), Positives = 96/204 (47%), Gaps = 20/204 (9%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           MV+E LG  L+ +    + TF   TVL + I+++  +EY+H    ++ D+K  N L+G  
Sbjct: 114 MVLELLGPSLEDLFDLCDRTFSLKTVLMIAIQLISRMEYVHSKNLIYRDVKPENFLIGRP 173

Query: 59  --KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVE 116
             K    +++ D+GL+  Y      K       K   GT  + S++ H G   SRR D+E
Sbjct: 174 GNKTQQVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLE 233

Query: 117 ILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSV--LKWAPSGSSCC----EI 170
            LG+  + +L G LPW          Q  K + L E  Q +   K A      C    E+
Sbjct: 234 ALGHMFMYFLRGSLPW----------QGLKADTLKERYQKIGDTKRATPIEVLCENFPEM 283

Query: 171 AQFLVCAHSLAYDEKPNYQALKKI 194
           A +L     L + EKP+Y  L+K+
Sbjct: 284 ATYLRYVRRLDFFEKPDYDYLRKL 307


>gi|21624639 casein kinase 1, alpha 1-like [Homo sapiens]
          Length = 337

 Score = 90.1 bits (222), Expect = 3e-18
 Identities = 59/196 (30%), Positives = 98/196 (50%), Gaps = 5/196 (2%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           +VM+ LG  L+ +    +  F   TVL L  +M+  +EY+H   ++H DIK  N L+G  
Sbjct: 88  LVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTG 147

Query: 59  KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEIL 118
           ++ ++++L D+GL+ +Y  N   +       K   GT+ + S++AH G+  SRR D+E L
Sbjct: 148 RHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYASINAHLGIEQSRRDDMESL 207

Query: 119 GYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVCAH 178
           GY  + +    LPW Q LK     +  K   + E   S            E A +L    
Sbjct: 208 GYVFMYFNRTSLPW-QGLK--AMTKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCR 264

Query: 179 SLAYDEKPNYQALKKI 194
            L ++E P+Y  L+++
Sbjct: 265 GLRFEEVPDYMYLRQL 280


>gi|153791733 casein kinase 1, gamma 2 [Homo sapiens]
          Length = 415

 Score = 88.6 bits (218), Expect = 9e-18
 Identities = 62/205 (30%), Positives = 96/205 (46%), Gaps = 21/205 (10%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           MV+E LG  L+ +    + TF   TVL + I+++  +EY+H    ++ D+K  N L+G  
Sbjct: 117 MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRP 176

Query: 59  --KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVE 116
             K    +++ D+GL+  Y      K       K   GT  + S++ H G   SRR D+E
Sbjct: 177 GTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLE 236

Query: 117 ILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSV--LKWAPSGSSCC-----E 169
            LG+  + +L G LPW          Q  K + L E  Q +   K A      C     E
Sbjct: 237 ALGHMFMYFLRGSLPW----------QGLKADTLKERYQKIGDTKRATPIEVLCENFPEE 286

Query: 170 IAQFLVCAHSLAYDEKPNYQALKKI 194
           +A +L     L + EKP+Y  L+K+
Sbjct: 287 MATYLRYVRRLDFFEKPDYDYLRKL 311


>gi|98986450 casein kinase 1, gamma 1 [Homo sapiens]
          Length = 422

 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 71/251 (28%), Positives = 113/251 (45%), Gaps = 23/251 (9%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY- 58
           MV+E LG  L+ +    + TF   TVL + I++L  +EY+H    ++ D+K  N L+G  
Sbjct: 116 MVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLLSRMEYVHSKNLIYRDVKPENFLIGRQ 175

Query: 59  --KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVE 116
             K    +++ D+GL+  Y      K       K   GT  + S++ H G   SRR D+E
Sbjct: 176 GNKKEHVIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLE 235

Query: 117 ILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSV---LKWAPSGSSC----CE 169
            LG+  + +L G LPW          Q  K + L E  Q +    +  P  + C     E
Sbjct: 236 ALGHMFMYFLRGSLPW----------QGLKADTLKERYQKIGDTKRNTPIEALCENFPEE 285

Query: 170 IAQFLVCAHSLAYDEKPNYQALKKILNPHGIPLG-PLDFSTKGQSINVHTP-NSQKVDSQ 227
           +A +L     L + EKP+Y+ L+ +        G   D++       + TP  S  VDS 
Sbjct: 286 MATYLRYVRRLDFFEKPDYEYLRTLFTDLFEKKGYTFDYAYDWVGRPIPTPVGSVHVDSG 345

Query: 228 KAATKQVNKAH 238
            +A  + +  H
Sbjct: 346 ASAITRESHTH 356


>gi|68303575 casein kinase 1, alpha 1 isoform 1 [Homo sapiens]
          Length = 365

 Score = 85.9 bits (211), Expect = 6e-17
 Identities = 61/224 (27%), Positives = 98/224 (43%), Gaps = 33/224 (14%)

Query: 1   MVMERLGIDLQKISGQ-NGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLG-- 57
           +VM+ LG  L+ +    +  F   TVL L  +M+  +EY+H   ++H DIK  N L+G  
Sbjct: 88  LVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIG 147

Query: 58  ---------------------------YKNPDQVYLADYGLSYRYCPNGNHKQYQENPRK 90
                                      +   +Q++L D+GL+ +Y  N   +       K
Sbjct: 148 RHCNKCLESPVGKRKRSMTVSTSQDPSFSGLNQLFLIDFGLAKKYRDNRTRQHIPYREDK 207

Query: 91  GHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLL 150
              GT  + S++AH G+  SRR D+E LGY ++ +    LPW Q LK   A +  K   +
Sbjct: 208 NLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPW-QGLK--AATKKQKYEKI 264

Query: 151 DELPQSVLKWAPSGSSCCEIAQFLVCAHSLAYDEKPNYQALKKI 194
            E   S            E A +L     L ++E P+Y  L+++
Sbjct: 265 SEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQL 308


>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
          Length = 1321

 Score = 82.8 bits (203), Expect = 5e-16
 Identities = 62/198 (31%), Positives = 98/198 (49%), Gaps = 14/198 (7%)

Query: 1   MVMERLGIDLQKI--SGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY 58
           +VM+  G +L  +  S   GTF  ST L+LG ++L+ +E IH   ++H DIK +N  +G 
Sbjct: 105 VVMQLQGRNLADLRRSQPRGTFTLSTTLRLGKQILESIEAIHSVGFLHRDIKPSNFAMGR 164

Query: 59  --KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVE 116
                 + Y+ D+GL+ +Y       +   N   G  GT+ + S++AHK   + R  D+ 
Sbjct: 165 LPSTYRKCYMLDFGLARQYTNTTGDVRPPRNV-AGFRGTVRYASVNAHKNREMGRHDDLW 223

Query: 117 ILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVC 176
            L Y ++ +  G+LPW + +KD   V   K      +   +LK  PS     E   FL  
Sbjct: 224 SLFYMLVEFAVGQLPW-RKIKDKEQVGMIKEKYEHRM---LLKHMPS-----EFHLFLDH 274

Query: 177 AHSLAYDEKPNYQALKKI 194
             SL Y  KP+YQ +  +
Sbjct: 275 IASLDYFTKPDYQLIMSV 292


>gi|116812624 tau tubulin kinase 2 [Homo sapiens]
          Length = 1244

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 62/200 (31%), Positives = 99/200 (49%), Gaps = 14/200 (7%)

Query: 1   MVMERLGIDLQKI--SGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGY 58
           +VM+  G +L  +  S   GTF  ST L+LG ++L+ +E IH   ++H DIK +N  +G 
Sbjct: 92  VVMQLQGRNLADLRRSQSRGTFTISTTLRLGRQILESIESIHSVGFLHRDIKPSNFAMGR 151

Query: 59  --KNPDQVYLADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVE 116
                 + Y+ D+GL+ R   N            G  GT+ + S++AH+   + R  D+ 
Sbjct: 152 FPSTCRKCYMLDFGLA-RQFTNSCGDVRPPRAVAGFRGTVRYASINAHRNREMGRHDDLW 210

Query: 117 ILGYCMLRWLCGKLPWEQNLKDPVAVQTAKTNLLDELPQSVLKWAPSGSSCCEIAQFLVC 176
            L Y ++ ++ G+LPW + +KD   V + K      L   +LK  P      E + FL  
Sbjct: 211 SLFYMLVEFVVGQLPW-RKIKDKEQVGSIKERYDHRL---MLKHLPP-----EFSIFLDH 261

Query: 177 AHSLAYDEKPNYQALKKILN 196
             SL Y  KP+YQ L  + +
Sbjct: 262 ISSLDYFTKPDYQLLTSVFD 281


>gi|153945765 mitogen-activated protein kinase kinase kinase 1 [Homo
            sapiens]
          Length = 1512

 Score = 62.0 bits (149), Expect = 9e-10
 Identities = 37/116 (31%), Positives = 59/116 (50%), Gaps = 6/116 (5%)

Query: 18   GTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYRYCP 77
            G FK+S V+    ++L  L Y+HEN+ +H D+K ANLL+      ++ +AD+G + R   
Sbjct: 1339 GAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLID-STGQRLRIADFGAAARLAS 1397

Query: 78   NGNHK-QYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPW 132
             G    ++Q        GTI F + +  +G    R  DV  +G  ++   C K PW
Sbjct: 1398 KGTGAGEFQGQLL----GTIAFMAPEVLRGQQYGRSCDVWSVGCAIIEMACAKPPW 1449


>gi|4826878 oxidative-stress responsive 1 [Homo sapiens]
          Length = 527

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 22/57 (38%), Positives = 37/57 (64%), Gaps = 2/57 (3%)

Query: 16  QNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLS 72
           ++G   +ST+  +   +L+ LEY+H+N  +H D+KA N+LLG      V +AD+G+S
Sbjct: 114 KSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNILLG--EDGSVQIADFGVS 168


>gi|42794767 mitogen-activated protein kinase kinase kinase 3
           isoform 1 [Homo sapiens]
          Length = 657

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 35/120 (29%), Positives = 54/120 (45%), Gaps = 12/120 (10%)

Query: 18  GTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYR--- 74
           G   +S   +   ++L+ + Y+H N  VH DIK AN+L    +   V L D+G S R   
Sbjct: 490 GALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANIL--RDSAGNVKLGDFGASKRLQT 547

Query: 75  YCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 134
            C +G          +   GT  + S +   G    R++DV  LG  ++  L  K PW +
Sbjct: 548 ICMSG-------TGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 600


>gi|42794765 mitogen-activated protein kinase kinase kinase 3
           isoform 2 [Homo sapiens]
          Length = 626

 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 35/120 (29%), Positives = 54/120 (45%), Gaps = 12/120 (10%)

Query: 18  GTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLADYGLSYR--- 74
           G   +S   +   ++L+ + Y+H N  VH DIK AN+L    +   V L D+G S R   
Sbjct: 459 GALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANIL--RDSAGNVKLGDFGASKRLQT 516

Query: 75  YCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCGKLPWEQ 134
            C +G          +   GT  + S +   G    R++DV  LG  ++  L  K PW +
Sbjct: 517 ICMSG-------TGMRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAE 569


>gi|115298645 mitogen-activated protein kinase kinase kinase 14
           [Homo sapiens]
          Length = 947

 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 40/143 (27%), Positives = 60/143 (41%), Gaps = 11/143 (7%)

Query: 7   GIDLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYL 66
           G  L ++  + G   +   L    + L+ LEY+H    +HGD+KA N+LL   +     L
Sbjct: 474 GGSLGQLVKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLS-SDGSHAAL 532

Query: 67  ADYGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSD--VEILGYC--M 122
            D+G +    P+G  K             I  T       V L R  D  V++   C  M
Sbjct: 533 CDFGHAVCLQPDGLGKSLLT------GDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMM 586

Query: 123 LRWLCGKLPWEQNLKDPVAVQTA 145
           L  L G  PW Q  + P+ ++ A
Sbjct: 587 LHMLNGCHPWTQFFRGPLCLKIA 609


>gi|83776600 aurora kinase B [Homo sapiens]
          Length = 344

 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 40/158 (25%), Positives = 69/158 (43%), Gaps = 24/158 (15%)

Query: 9   DLQKISGQNGTFKKSTVLQLGIRMLDVLEYIHENEYVHGDIKAANLLLGYKNPDQVYLAD 68
           +L K   ++ TF +     +   + D L Y H  + +H DIK  NLLLG K   ++ +AD
Sbjct: 161 ELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKG--ELKIAD 218

Query: 69  YGLSYRYCPNGNHKQYQENPRKGHNGTIEFTSLDAHKGVALSRRSDVEILGYCMLRWLCG 128
           +G S  + P+          RK   GT+++   +  +G   + + D+  +G      L G
Sbjct: 219 FGWSV-HAPSLR--------RKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVG 269

Query: 129 KLPWEQ-------------NLKDPVAVQTAKTNLLDEL 153
             P+E              +LK P +V     +L+ +L
Sbjct: 270 NPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKL 307


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.132    0.394 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,606,143
Number of Sequences: 37866
Number of extensions: 651108
Number of successful extensions: 2753
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 242
Number of HSP's successfully gapped in prelim test: 293
Number of HSP's that attempted gapping in prelim test: 2361
Number of HSP's gapped (non-prelim): 615
length of query: 390
length of database: 18,247,518
effective HSP length: 104
effective length of query: 286
effective length of database: 14,309,454
effective search space: 4092503844
effective search space used: 4092503844
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.