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Search of human proteins with 208973262
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|208973262 low density lipoprotein-related protein 12 isoform
b precursor [Homo sapiens]
(840 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208973262 low density lipoprotein-related protein 12 isoform ... 1783 0.0
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 1772 0.0
gi|167555125 low density lipoprotein receptor-related protein 3 ... 605 e-173
gi|32490559 low density lipoprotein receptor-related protein 10 ... 378 e-104
gi|11415040 matriptase [Homo sapiens] 137 3e-32
gi|93102379 low density lipoprotein-related protein 1B precursor... 134 3e-31
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 126 1e-28
gi|4507157 sortilin-related receptor containing LDLR class A rep... 124 4e-28
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 121 3e-27
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa... 117 3e-26
gi|6912724 tolloid-like 2 [Homo sapiens] 117 4e-26
gi|13899255 membrane frizzled-related protein [Homo sapiens] 116 1e-25
gi|22547221 tolloid-like 1 [Homo sapiens] 115 2e-25
gi|157384998 low density lipoprotein receptor-related protein 4 ... 112 2e-24
gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens] 111 2e-24
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom... 107 4e-23
gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens] 102 2e-21
gi|126091152 cubilin [Homo sapiens] 96 2e-19
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap... 94 7e-19
gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo sap... 94 7e-19
gi|61744471 low density lipoprotein receptor-related protein 8 i... 92 2e-18
gi|65301119 low density lipoprotein receptor-related protein 8 i... 92 2e-18
gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens] 92 2e-18
gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens] 92 2e-18
gi|148539844 deleted in malignant brain tumors 1 isoform c precu... 92 2e-18
gi|148539842 deleted in malignant brain tumors 1 isoform b precu... 92 2e-18
gi|148539840 deleted in malignant brain tumors 1 isoform a precu... 92 2e-18
gi|148727288 low density lipoprotein receptor-related protein 6 ... 91 3e-18
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 90 8e-18
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 90 8e-18
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 1783 bits (4619), Expect = 0.0
Identities = 840/840 (100%), Positives = 840/840 (100%)
Query: 1 MACRWSTKESPRWRSALLLLFLAGVYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWF 60
MACRWSTKESPRWRSALLLLFLAGVYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWF
Sbjct: 1 MACRWSTKESPRWRSALLLLFLAGVYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWF 60
Query: 61 IRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWI 120
IRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWI
Sbjct: 61 IRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWI 120
Query: 121 RFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI 180
RFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI
Sbjct: 121 RFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI 180
Query: 181 CAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 240
CAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC
Sbjct: 181 CAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 240
Query: 241 GQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYD 300
GQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYD
Sbjct: 241 GQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYD 300
Query: 301 GLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWE 360
GLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWE
Sbjct: 301 GLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWE 360
Query: 361 IPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHC 420
IPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHC
Sbjct: 361 IPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHC 420
Query: 421 PNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVI 480
PNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVI
Sbjct: 421 PNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVI 480
Query: 481 GSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIP 540
GSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIP
Sbjct: 481 GSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIP 540
Query: 541 PVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLA 600
PVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLA
Sbjct: 541 PVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLA 600
Query: 601 LVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKV 660
LVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKV
Sbjct: 601 LVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVAAPLPQKV 660
Query: 661 PPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALSRMTQGLRW 720
PPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALSRMTQGLRW
Sbjct: 661 PPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVSPARHQLTSALSRMTQGLRW 720
Query: 721 VRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSSDFDVNDCSRPLLDLA 780
VRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSSDFDVNDCSRPLLDLA
Sbjct: 721 VRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPISDGSSDFDVNDCSRPLLDLA 780
Query: 781 SDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTLKNETSDDEALLLC 840
SDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTLKNETSDDEALLLC
Sbjct: 781 SDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDTCLEVTLKNETSDDEALLLC 840
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 1772 bits (4589), Expect = 0.0
Identities = 840/859 (97%), Positives = 840/859 (97%), Gaps = 19/859 (2%)
Query: 1 MACRWSTKESPRWRSALLLLFLAGVY-------------------ACGETPEQIRAPSGI 41
MACRWSTKESPRWRSALLLLFLAGVY ACGETPEQIRAPSGI
Sbjct: 1 MACRWSTKESPRWRSALLLLFLAGVYGNGALAEHSENVHISGVSTACGETPEQIRAPSGI 60
Query: 42 ITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYR 101
ITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYR
Sbjct: 61 ITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYR 120
Query: 102 ACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIP 161
ACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIP
Sbjct: 121 ACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIP 180
Query: 162 EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCD 221
EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCD
Sbjct: 181 EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCD 240
Query: 222 GNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILR 281
GNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILR
Sbjct: 241 GNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILR 300
Query: 282 FTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVN 341
FTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVN
Sbjct: 301 FTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVN 360
Query: 342 AARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC 401
AARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC
Sbjct: 361 AARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPC 420
Query: 402 SRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGS 461
SRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGS
Sbjct: 421 SRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGS 480
Query: 462 DEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAEL 521
DEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAEL
Sbjct: 481 DEENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAEL 540
Query: 522 LRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSS 581
LRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSS
Sbjct: 541 LRREAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSS 600
Query: 582 NIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENE 641
NIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENE
Sbjct: 601 NIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDTDTENE 660
Query: 642 RRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVS 701
RRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVS
Sbjct: 661 RRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVEPPSVS 720
Query: 702 PARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPIS 761
PARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPIS
Sbjct: 721 PARHQLTSALSRMTQGLRWVRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVEMLIPIS 780
Query: 762 DGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDT 821
DGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDT
Sbjct: 781 DGSSDFDVNDCSRPLLDLASDQGQGLRQPYNATNPGVRPSNRDGPCERCGIVHTAQIPDT 840
Query: 822 CLEVTLKNETSDDEALLLC 840
CLEVTLKNETSDDEALLLC
Sbjct: 841 CLEVTLKNETSDDEALLLC 859
>gi|167555125 low density lipoprotein receptor-related protein 3
[Homo sapiens]
Length = 770
Score = 605 bits (1559), Expect = e-173
Identities = 302/600 (50%), Positives = 398/600 (66%), Gaps = 36/600 (6%)
Query: 27 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 86
AC EQ G+I SP WP YP NCSW+I+ + G++ITISF++FD++ S +C+L
Sbjct: 42 ACSGKLEQHTERRGVIYSPAWPLNYPPGTNCSWYIQGDRGDMITISFRNFDVEESHQCSL 101
Query: 87 DWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNIS--RKGFRLAYFSGKS 142
DWL + E++R CGS IPP +IS++DH+WI FHSD + S +GFRL+Y GK
Sbjct: 102 DWLLLGPAAPPRQEAFRLCGSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKL 161
Query: 143 EEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 202
+ +C D+FRC NGKC+P W+CN +DECGD SDE C+ A+ P + C F
Sbjct: 162 GQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSL---CPGGTFP 218
Query: 203 CL-SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFY- 260
C +R T+ CLP +CDG DC D DE C CG+ L FYG+F SP D +
Sbjct: 219 CSGARSTR---CLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASP---DLFG 272
Query: 261 ----PPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAF 316
P +CTWL+DT D R+V+L+ + +L GY DYV++Y+GL E +LL+ L+
Sbjct: 273 AARGPSDLHCTWLVDTQDSRRVLLQL-ELRL---GYDDYVQVYEGLGERGDRLLQTLSYR 328
Query: 317 DSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCG----------GN 366
+H P+++ ++ G++ V + A +A GFNATYQV G+CLPWE PCG G+
Sbjct: 329 SNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDGGSLGD 388
Query: 367 WGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSR-NGVCYPRSDRCNYQNHCPNGSD 425
GC++E QRCDG+WHC +GRDE C C +++PC +G+CY +DRCN Q CP+G+D
Sbjct: 389 QGCFSEPQRCDGWWHCASGRDEQGCPACPPDQYPCEGGSGLCYTPADRCNNQKSCPDGAD 448
Query: 426 EKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLIC 485
EKNCF CQPG FHC N C+FE+W CD Q+DC DGSDE C VP +VITAA+IGSL+C
Sbjct: 449 EKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLAAVPRKVITAALIGSLVC 508
Query: 486 GLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLRREAPPSYGQLIAQGLIPPVEDF 545
GLLLVIALGC KLYSLR E R+FETQ++R+EAE +RREAPPSYGQLIAQGLIPPVEDF
Sbjct: 509 GLLLVIALGCAFKLYSLRTQEYRAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDF 568
Query: 546 PVCSPNQASVLENLRLAVRSQL-GFTSVRLPMAGRSSNIWNRIFNFARSRHSGSLALVSA 604
PV S +QASVL+NLR A+R Q+ S R P R +WNR+F+ R+ G + L++A
Sbjct: 569 PVYSASQASVLQNLRTAMRRQMRRHASRRGPSRRRLGRLWNRLFHRPRAPR-GQIPLLTA 627
>gi|32490559 low density lipoprotein receptor-related protein 10
precursor [Homo sapiens]
Length = 713
Score = 378 bits (970), Expect = e-104
Identities = 266/787 (33%), Positives = 366/787 (46%), Gaps = 131/787 (16%)
Query: 15 SALLLLFLAGV-----------YACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRA 63
+ LLLL L G +AC + P + G + P + NC+W I
Sbjct: 4 ATLLLLLLGGALAHPDRIIFPNHACEDPPAVLLEVQGTLQRPLVRDSRTSPANCTWLILG 63
Query: 64 NPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFH 123
+ + +TI FQ + C + LT+ + ++ + P P ++ I +
Sbjct: 64 SKEQTVTIRFQKLHLA----CGSERLTLRS--PLQPLISLCEAPPSPLQLPGGNVTITYS 117
Query: 124 SDDNISR--KGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEIC 181
+ +GF L+Y + C ++F+C N +C+ +C+ +D CGD SDE C
Sbjct: 118 YAGARAPMGQGFLLSY---SQDWLMCLQEEFQCLNHRCVSAVQRCDGVDACGDGSDEAGC 174
Query: 182 AKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCG 241
+ + P P LP C
Sbjct: 175 SSDPFPGLTPRPVP-----------------SLP------------------------CN 193
Query: 242 QWLKYFYGTFNSPNYPDFYPPG--SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIY 299
L+ FYG F+SP Y +C WL+D D R++ +RFT L G+GD V +Y
Sbjct: 194 VTLEDFYGVFSSPGYTHLASVSHPQSCHWLLDPHDGRRLAVRFTALDL---GFGDAVHVY 250
Query: 300 DGL-EENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLP 358
DG +LLR LT F + +TV + SGQ V + + RGFNATY V G+CLP
Sbjct: 251 DGPGPPESSRLLRSLTHFSNGKAVTVETLSGQAVVSYHTVAWSNGRGFNATYHVRGYCLP 310
Query: 359 WEIPCGGNWG----------CYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNG--- 405
W+ PCG G CY+E QRCDG W C +G DE +C C FPC G
Sbjct: 311 WDRPCGLGSGLGAGEGLGERCYSEAQRCDGSWDCADGTDEEDCPGCPPGHFPCGAAGTSG 370
Query: 406 --VCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 463
CY +DRCNYQ C +G+DE+ C CQPGNF C++ +CV+E+WVCD Q DC DGSDE
Sbjct: 371 ATACYLPADRCNYQTFCADGADERRCRHCQPGNFRCRDEKCVYETWVCDGQPDCADGSDE 430
Query: 464 ENCPVIVPTRVITAAVIGSLICGLLLVIALGCTCKLYSLRMFERRSFETQLSRVEAELLR 523
+C ++P +VITAAVIGSL+CGLLLVIALGCTCKLY++R E F LSR+EAE+++
Sbjct: 431 WDCSYVLPRKVITAAVIGSLVCGLLLVIALGCTCKLYAIRTQEYSIF-APLSRMEAEIVQ 489
Query: 524 REAPPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVR------SQLGFTSVRLPMA 577
++APPSYGQLIAQG IPPVEDFP +PN SVL NLR ++ + G R
Sbjct: 490 QQAPPSYGQLIAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGPGARRRQR 549
Query: 578 GR-SSNIWNRIFNFARSRHSGSLALVSADGDEVVPSQSTSREPERNHTHRSLFSVESDDT 636
GR + R+ + + + A S +V PS + T
Sbjct: 550 GRLMRRLVRRLRRWGLLPRTNTPARASEARSQVTPSAAP-------------LEALDGGT 596
Query: 637 DTENERRDMAGASGGVAAPLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSVE 696
E + G G A PLP K P + AS+S T T E
Sbjct: 597 GPAREGGAVGGQDGEQAPPLPIKAPLPS---------ASTSPAPT-----------TVPE 636
Query: 697 PPSVSPARHQLTSALSRMTQGLRW-VRFTLGRSSSLSQNQSPLRQLDNGVSGREDDDDVE 755
P P+ S LS + Q LR + +LG P V ED+DDV
Sbjct: 637 APGPLPSLPLEPSLLSGVVQALRGRLLPSLGPPGPTRSPPGP----HTAVLALEDEDDV- 691
Query: 756 MLIPISD 762
+L+P+++
Sbjct: 692 LLVPLAE 698
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 137 bits (346), Expect = 3e-32
Identities = 84/236 (35%), Positives = 116/236 (49%), Gaps = 17/236 (7%)
Query: 239 TCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKI 298
+CG L+ GTFNSP YP YPP +CTW I+ +++ V +RF F L G
Sbjct: 339 SCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCP 398
Query: 299 YDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLP 358
D +E N K + F V S+S +I V F +D+ GF A Y
Sbjct: 399 KDYVEINGEKYCGERSQF------VVTSNSNKITVRFHSDQSYTDTGFLAEY----LSYD 448
Query: 359 WEIPCGGNWGCYT-----EQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDR 413
PC G + C T ++ RCDG+ C + DE NC+ +F C +N C P
Sbjct: 449 SSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTC-KNKFCKPLFWV 507
Query: 414 CNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 469
C+ N C + SDE+ C C F C N +C+ +S C+ +DDCGDGSDE +CP +
Sbjct: 508 CDSVNDCGDNSDEQGCS-CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKV 562
Score = 95.5 bits (236), Expect = 2e-19
Identities = 70/249 (28%), Positives = 104/249 (41%), Gaps = 66/249 (26%)
Query: 34 QIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQG----SRRCNLDWL 89
++R G SP +P YP I+C+W I + + + F+ F + + C D++
Sbjct: 343 RLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYV 402
Query: 90 TIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEP---- 145
I N E Y CG S+ + I +RFHSD + + GF Y S S +P
Sbjct: 403 EI----NGEKY--CGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQ 456
Query: 146 ----------------------------NCACD---QFRCGNGKCIPEAWKCNNMDECGD 174
NC+CD QF C N C P W C+++++CGD
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGD 516
Query: 175 SSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID 234
+SDE+ C+ C F+C + CL +S +C+G DC D DE
Sbjct: 517 NSDEQGCS-------------CPAQTFRCSNG-----KCLSKSQQCNGKDDCGDGSDEAS 558
Query: 235 C---DVPTC 240
C +V TC
Sbjct: 559 CPKVNVVTC 567
Score = 73.6 bits (179), Expect = 7e-13
Identities = 42/103 (40%), Positives = 56/103 (54%), Gaps = 18/103 (17%)
Query: 142 SEEPNCAC--DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN 199
S+E C+C FRC NGKC+ ++ +CN D+CGD SDE C K N T C +
Sbjct: 518 SDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPK-VNVVT------CTKH 570
Query: 200 QFQCLSRFTKVYTCLPE-SLKCDGNIDCLDLGDEIDCDVPTCG 241
++CL+ CL + + +CDG DC D DE DCD CG
Sbjct: 571 TYRCLNGL-----CLSKGNPECDGKEDCSDGSDEKDCD---CG 605
Score = 54.7 bits (130), Expect = 4e-07
Identities = 66/266 (24%), Positives = 92/266 (34%), Gaps = 57/266 (21%)
Query: 251 FNSPNYPDF-YPPGSNCTWLIDTGDHRKVI-LRFTDFKL---DGTGYGDYVKIYDGLEE- 304
F +P +PD YP + C W + GD V+ L F F L D G D V +Y+ L
Sbjct: 228 FTTPGFPDSPYPAHARCQWAL-RGDADSVLSLTFRSFDLASCDERG-SDLVTVYNTLSPM 285
Query: 305 NPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCG 364
PH L+++ + LT SS + + + GF AT+ F LP CG
Sbjct: 286 EPHALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATF----FQLPRMSSCG 341
Query: 365 GNW-------------GCYTEQQRCDGYWHCPNGR-------------DETNCTMCQKEE 398
G G Y C PN + C K+
Sbjct: 342 GRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDY 401
Query: 399 FPCSRNGVCYPR--------SDRCNYQNHCPNGSDEKNCFFCQ----------PGNFHCK 440
+ C R S++ + H + F + PG F C+
Sbjct: 402 VEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTG-FLAEYLSYDSSDPCPGQFTCR 460
Query: 441 NNRCVFESWVCDSQDDCGDGSDEENC 466
RC+ + CD DC D SDE NC
Sbjct: 461 TGRCIRKELRCDGWADCTDHSDELNC 486
Score = 53.1 bits (126), Expect = 1e-06
Identities = 59/260 (22%), Positives = 99/260 (38%), Gaps = 69/260 (26%)
Query: 43 TSPGWP-SEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI-ETYKNIESY 100
T+PG+P S YPA C W +R + +++++F+ FD+ D +T+ T +E +
Sbjct: 229 TTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPH 288
Query: 101 ---RACGSTIPPPY----ISSQDHIWIRFHSDDNISRKGFRLAYF--------SGKSEE- 144
+ CG T PP Y SSQ+ + I ++ GF +F G+ +
Sbjct: 289 ALVQLCG-TYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKA 347
Query: 145 --------------PNCACD-------------QFR--------CGNGKCIPEAWKCNNM 169
PN C +F+ G C + + N
Sbjct: 348 QGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGE 407
Query: 170 DECGDSSDEEICAKEANPPTAAAFQPCAY-------------NQFQCLSRFT-KVYTCLP 215
CG+ S + + +N T +Y + C +FT + C+
Sbjct: 408 KYCGERS-QFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIR 466
Query: 216 ESLKCDGNIDCLDLGDEIDC 235
+ L+CDG DC D DE++C
Sbjct: 467 KELRCDGWADCTDHSDELNC 486
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 134 bits (338), Expect = 3e-31
Identities = 98/330 (29%), Positives = 129/330 (39%), Gaps = 55/330 (16%)
Query: 146 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 205
NC QFRC KCIP WKC+ +D+CGD SDE P F+ C +FQC +
Sbjct: 3316 NCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDE--------PDDCPEFR-CQPGRFQCGT 3366
Query: 206 RFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSN 265
C + CDG DC D DE++CD C G F P
Sbjct: 3367 GL-----CALPAFICDGENDCGDNSDELNCDTHVC------LSGQFKCTKNQKCIPVNLR 3415
Query: 266 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 325
C D GD D + + DY + + H + ++ +
Sbjct: 3416 CNGQDDCGDEEDE----RDCP-ENSCSPDYFQC----KTTKHCISKLWVCDEDPD----- 3461
Query: 326 SSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNG 385
CAD + A T C P E C N C + RCD C +
Sbjct: 3462 ----------CADASDEANCDKKT------CGPHEFQCKNN-NCIPDHWRCDSQNDCSDN 3504
Query: 386 RDETNCT--MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC-FFCQPGNFHCKNN 442
DE NC C ++F C+ NG C C+ C +GSDE+NC C F C N
Sbjct: 3505 SDEENCKPQTCTLKDFLCA-NGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQFRCSNG 3563
Query: 443 RCVFESWVCDSQDDCGDGSDEENCPVIVPT 472
+C+ W CD +DC G DE++C PT
Sbjct: 3564 QCIPAKWKCDGHEDCKYGEDEKSCEPASPT 3593
Score = 126 bits (317), Expect = 7e-29
Identities = 102/327 (31%), Positives = 138/327 (42%), Gaps = 62/327 (18%)
Query: 147 CACDQFRCG-NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 205
C QF+C N KCIP +CN D+CGD DE C + + C+ + FQC
Sbjct: 3396 CLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENS----------CSPDYFQC-- 3443
Query: 206 RFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSN 265
+ TK C+ + CD + DC D DE +CD TCG +F +N
Sbjct: 3444 KTTK--HCISKLWVCDEDPDCADASDEANCDKKTCGPH--------------EFQCKNNN 3487
Query: 266 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 325
C DH + D + D + D EEN L F A V
Sbjct: 3488 CI-----PDHWRC-----DSQNDCSDNSD--------EENCKPQTCTLKDFLC-ANGDCV 3528
Query: 326 SSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNG 385
SS +C + A G + + C + C N C + +CDG+ C G
Sbjct: 3529 SSR-----FWCDGDFDCADGSDER-NCETSCSKDQFRCS-NGQCIPAKWKCDGHEDCKYG 3581
Query: 386 RDETNCT----MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF-CQPGNFHCK 440
DE +C C E+ C+ +G C S +CN + C +GSDE +C C+ F CK
Sbjct: 3582 EDEKSCEPASPTCSSREYICASDG-CISASLKCNGEYDCADGSDEMDCVTECKEDQFRCK 3640
Query: 441 NN-RCVFESWVCDSQDDCGDGSDEENC 466
N C+ W+CD DC DGSDEENC
Sbjct: 3641 NKAHCIPIRWLCDGIHDCVDGSDEENC 3667
Score = 126 bits (316), Expect = 1e-28
Identities = 104/374 (27%), Positives = 147/374 (39%), Gaps = 62/374 (16%)
Query: 127 NISRKGFRLAYFSGKSEEPNCACD---QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAK 183
N S +G R+ + N +C+ +F CGNG+CI C+ + C D SDE++
Sbjct: 2488 NCSCRGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYC 2547
Query: 184 EANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQW 243
E N F+PC YN+ C+P CDG DC D DE+DC V TC
Sbjct: 2548 E-NRSCRRGFKPC-YNR-----------RCIPHGKLCDGENDCGDNSDELDCKVSTCATV 2594
Query: 244 -LKYFYGTF----------------------NSPNYPDFYPPGSNCTWLIDTGDHRKVIL 280
+ GT N+ + FY G T I +L
Sbjct: 2595 EFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVL 2654
Query: 281 RFTDFKLDGTG-YGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADK 339
+ DG+ GDY +N HK + S + C +
Sbjct: 2655 --PTWICDGSNDCGDYSDELKCPVQNKHKC--------EENYFSCPSGRCILNTWICDGQ 2704
Query: 340 VNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETN----CTMCQ 395
+ G + + D C + C C ++ CDG C +G DE++ C
Sbjct: 2705 KDCEDGRDE-FHCDSSCSWNQFACSAQ-KCISKHWICDGEDDCGDGLDESDSICGAITCA 2762
Query: 396 KEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGN------FHCKNNRCVFESW 449
+ F C + C PR C+ + CP+GSDE + C P N F C N C+ + +
Sbjct: 2763 ADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTCDENAFMCHNKVCIPKQF 2822
Query: 450 VCDSQDDCGDGSDE 463
VCD DDCGDGSDE
Sbjct: 2823 VCDHDDDCGDGSDE 2836
Score = 116 bits (291), Expect = 8e-26
Identities = 95/327 (29%), Positives = 134/327 (40%), Gaps = 61/327 (18%)
Query: 144 EPNCACDQFRCGNGK-CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 202
E +C+ D F+C K CI + W C+ +C D+SDE C K+ C ++FQ
Sbjct: 3433 ENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKT----------CGPHEFQ 3482
Query: 203 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 262
C K C+P+ +CD DC D DE +C TC LK F F+
Sbjct: 3483 C-----KNNNCIPDHWRCDSQNDCSDNSDEENCKPQTC--TLKDFLCANGDCVSSRFWCD 3535
Query: 263 GS-NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAP 321
G +C D D R T D + I + + H+ + S P
Sbjct: 3536 GDFDCA---DGSDERNC---ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEP 3589
Query: 322 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWH 381
+ SS R + CA DG C+ + C G +
Sbjct: 3590 ASPTCSS---REYICAS--------------DG-CISASLKCNGE-------------YD 3618
Query: 382 CPNGRDETNC-TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC----FFCQPGN 436
C +G DE +C T C++++F C C P C+ + C +GSDE+NC C+
Sbjct: 3619 CADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADE 3678
Query: 437 FHCKNNRCVFESWVCDSQDDCGDGSDE 463
F C N+ C WVCD +DDCGD SDE
Sbjct: 3679 FLCNNSLCKLHFWVCDGEDDCGDNSDE 3705
Score = 110 bits (274), Expect = 7e-24
Identities = 107/423 (25%), Positives = 149/423 (35%), Gaps = 129/423 (30%)
Query: 141 KSEEPNCACDQFRCGNG-------KCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAF 193
KS+E C+ C G +CIP C+ ++CGD+SDE C
Sbjct: 2539 KSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVST-------- 2590
Query: 194 QPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNS 253
CA +F+C TC+P S +C+ NIDC D DE +C+ C
Sbjct: 2591 --CATVEFRCADG-----TCIPRSARCNQNIDCADASDEKNCNNTDCTH----------- 2632
Query: 254 PNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTG-YGDYVKIYDGLEENPHKLLR- 311
FY G T I +L + DG+ GDY +N HK
Sbjct: 2633 -----FYKLGVKTTGFIRCNSTSLCVL--PTWICDGSNDCGDYSDELKCPVQNKHKCEEN 2685
Query: 312 ---------VLTAF-----------------DSHAPLTVVSSSGQ--IRVHF-CADKVNA 342
+L + DS + S Q I H+ C + +
Sbjct: 2686 YFSCPSGRCILNTWICDGQKDCEDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDC 2745
Query: 343 ARGFNATYQVDGF--CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT------MC 394
G + + + G C C G+ C CDG CP+G DE + C
Sbjct: 2746 GDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTAGCAPNNTC 2805
Query: 395 QKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE------KNC----FFCQPGN-------- 436
+ F C N VC P+ C++ + C +GSDE + C F C G
Sbjct: 2806 DENAFMC-HNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQ 2864
Query: 437 -------------------------------FHCKNNRCVFESWVCDSQDDCGDGSDEEN 465
F CKN RC+ +CD++DDCGDGSDE N
Sbjct: 2865 CDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERN 2924
Query: 466 CPV 468
C +
Sbjct: 2925 CHI 2927
Score = 107 bits (267), Expect = 5e-23
Identities = 91/313 (29%), Positives = 131/313 (41%), Gaps = 68/313 (21%)
Query: 144 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQC 203
E +C+ DQFRC NG+CIP WKC+ ++C DE+ C E PT C+ ++ C
Sbjct: 3550 ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSC--EPASPT------CSSREYIC 3601
Query: 204 LSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 263
S C+ SLKC+G DC D DE+DC V C + F N P
Sbjct: 3602 ASD-----GCISASLKCNGEYDCADGSDEMDC-VTECKE------DQFRCKNKAHCIP-- 3647
Query: 264 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 323
WL D G H V DG+ EEN + + A +
Sbjct: 3648 --IRWLCD-GIHDCV---------DGSD-----------EENCERGGNICRADE------ 3678
Query: 324 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIP------CGGNWGCYTEQQRCD 377
+ ++ ++HF G N+ D C+ + P C N C +Q C+
Sbjct: 3679 FLCNNSLCKLHFWVCDGEDDCGDNSDEAPD-MCVKFLCPSTRPHRCRNNRICLQSEQMCN 3737
Query: 378 GYWHCPNGRDETNC--------TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 429
G C + DE +C C+K+EF CS N C P +C+ + C +GSDE+ C
Sbjct: 3738 GIDECGDNSDEDHCGGKLTYKARPCKKDEFACS-NKKCIPMDLQCDRLDDCGDGSDEQGC 3796
Query: 430 FFCQPGNFHCKNN 442
P + C++N
Sbjct: 3797 RIA-PTEYTCEDN 3808
Score = 107 bits (266), Expect = 6e-23
Identities = 93/345 (26%), Positives = 137/345 (39%), Gaps = 86/345 (24%)
Query: 143 EEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 202
++ C +F+C N CIP+ W+C++ ++C D+SDEE C Q C F
Sbjct: 3472 DKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKP----------QTCTLKDFL 3521
Query: 203 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 262
C + C+ CDG+ DC D DE +C+ +C K + N P
Sbjct: 3522 CANG-----DCVSSRFWCDGDFDCADGSDERNCET-SCS---KDQFRCSNGQCIP----- 3567
Query: 263 GSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL 322
W D + K YG+ K S P
Sbjct: 3568 ---AKWKCDGHEDCK--------------YGEDEK--------------------SCEPA 3590
Query: 323 TVVSSSGQIRVHFCADK--VNAARGFNATYQ-VDGF--------CLPWEIPCGGNWGCYT 371
+ SS R + CA ++A+ N Y DG C + C C
Sbjct: 3591 SPTCSS---REYICASDGCISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIP 3647
Query: 372 EQQRCDGYWHCPNGRDETNC----TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE- 426
+ CDG C +G DE NC +C+ +EF C+ N +C C+ ++ C + SDE
Sbjct: 3648 IRWLCDGIHDCVDGSDEENCERGGNICRADEFLCN-NSLCKLHFWVCDGEDDCGDNSDEA 3706
Query: 427 -KNC--FFCQPGNFH-CKNNR-CVFESWVCDSQDDCGDGSDEENC 466
C F C H C+NNR C+ +C+ D+CGD SDE++C
Sbjct: 3707 PDMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHC 3751
Score = 105 bits (262), Expect = 2e-22
Identities = 90/337 (26%), Positives = 134/337 (39%), Gaps = 71/337 (21%)
Query: 146 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 205
+C DQF+C N +CIP+ W C+ ++CG + DE +N A + C +QF C +
Sbjct: 885 SCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDE------SNQTCTA--RTCQVDQFSCGN 936
Query: 206 RFTKVYTCLPESLKCDGNIDCLDLGDEI-DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 264
C+P + CD DC D DE+ C+ PTC ++ +
Sbjct: 937 G-----RCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRC----------I 981
Query: 265 NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTV 324
+ W D+ D DG +E + V + FD+
Sbjct: 982 SSKWHCDSDDD----------------------CGDGSDE----VGCVHSCFDNQFRC-- 1013
Query: 325 VSSSGQIRVHFCADKVNAARGFNATYQVD---------GFCLPWEIPCGGNWGCYTEQQR 375
SS I H+ D N F+ Q++ C E C + C + R
Sbjct: 1014 -SSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWR 1072
Query: 376 CDGYWHCPNGRDETNCT----MC-QKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC- 429
CDG C +G DE C +C K +F C G C ++ C+ C + SDE +C
Sbjct: 1073 CDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCD 1132
Query: 430 -FFCQPGNFHCKNNR--CVFESWVCDSQDDCGDGSDE 463
F C P C N+ C+ +C+ + DC DGSDE
Sbjct: 1133 SFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
Score = 98.2 bits (243), Expect = 3e-20
Identities = 95/365 (26%), Positives = 129/365 (35%), Gaps = 85/365 (23%)
Query: 128 ISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI--CAKEA 185
+ G + G++ C +FRC N CI WKC+ D+C D SDE+ C +
Sbjct: 826 LDENGTTCTFNPGEALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHS 885
Query: 186 NPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLK 245
C +QF+C + C+P+ CDG DC G D TC
Sbjct: 886 ----------CPDDQFKCQNN-----RCIPKRWLCDGANDC---GSNEDESNQTC----- 922
Query: 246 YFYGTFNSPNYPDFYPPGSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGL 302
T + F C WL D D GD D +
Sbjct: 923 ----TARTCQVDQFSCGNGRCIPRAWLCDREDD----------------CGDQT---DEM 959
Query: 303 EENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ-----VDGFCL 357
LT F + + S C D + ++ + G C+
Sbjct: 960 ASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRCSSGRCI 1019
Query: 358 PWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET--NCTM--------CQKEEFPCSRNGVC 407
P G+W C DG C + DE NCT C EF C +G C
Sbjct: 1020 P------GHWAC-------DGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNC 1066
Query: 408 YPRSDRCNYQNHCPNGSDEKNC-----FFCQPGNFHC-KNNRCVFESWVCDSQDDCGDGS 461
P RC+ + C +GSDEK C F C RC+ ++WVCD DC D S
Sbjct: 1067 VPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQS 1126
Query: 462 DEENC 466
DE++C
Sbjct: 1127 DEDDC 1131
Score = 80.5 bits (197), Expect = 6e-15
Identities = 57/181 (31%), Positives = 78/181 (43%), Gaps = 19/181 (10%)
Query: 296 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKV-----NAARGFNATY 350
++IYD ++ + RV S L + RV CAD FN
Sbjct: 784 LQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGG----RVCACADNQLLDENGTTCTFNPGE 839
Query: 351 QVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDE--TNC--TMCQKEEFPCSRNGV 406
+ C E C N C + +CDG C +G DE NC C ++F C +N
Sbjct: 840 ALPHICKAGEFRCK-NRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKC-QNNR 897
Query: 407 CYPRSDRCNYQNHCPNGSDEKN----CFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSD 462
C P+ C+ N C + DE N CQ F C N RC+ +W+CD +DDCGD +D
Sbjct: 898 CIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTD 957
Query: 463 E 463
E
Sbjct: 958 E 958
Score = 75.5 bits (184), Expect = 2e-13
Identities = 71/286 (24%), Positives = 108/286 (37%), Gaps = 61/286 (21%)
Query: 197 AYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDE--IDCDVPTCGQWLKYFYGTFNSP 254
AY++F+C + C+ L CDG C D DE + C+ +C + K Y P
Sbjct: 2512 AYSEFECGNG-----ECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIP 2566
Query: 255 NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 314
+ G C D GD+ + D K+ ++ + DG
Sbjct: 2567 H-------GKLCDGENDCGDNSDEL----DCKVSTCATVEF-RCADG------------- 2601
Query: 315 AFDSHAPLTVVSSSGQIRVHF-CAD--------KVNAARGFNATYQVDGFCLPWEIPCGG 365
T + S + + CAD + + + GF I C
Sbjct: 2602 --------TCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGF-----IRCNS 2648
Query: 366 NWGCYTEQQRCDGYWHCPNGRDETNCTM-----CQKEEFPCSRNGVCYPRSDRCNYQNHC 420
C CDG C + DE C + C++ F C +G C + C+ Q C
Sbjct: 2649 TSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCP-SGRCILNTWICDGQKDC 2707
Query: 421 PNGSDEKNC-FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEEN 465
+G DE +C C F C +C+ + W+CD +DDCGDG DE +
Sbjct: 2708 EDGRDEFHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESD 2753
Score = 70.5 bits (171), Expect = 6e-12
Identities = 51/157 (32%), Positives = 64/157 (40%), Gaps = 27/157 (17%)
Query: 333 VHFC---ADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET 389
+H C +D+ N RG N C E C + C CDG C + DE
Sbjct: 3655 IHDCVDGSDEENCERGGN-------ICRADEFLCNNSL-CKLHFWVCDGEDDCGDNSDEA 3706
Query: 390 NCTMCQKEEFP------CSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF--------CQPG 435
MC K P C N +C CN + C + SDE +C C+
Sbjct: 3707 P-DMCVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKD 3765
Query: 436 NFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPT 472
F C N +C+ CD DDCGDGSDE+ C I PT
Sbjct: 3766 EFACSNKKCIPMDLQCDRLDDCGDGSDEQGCR-IAPT 3801
Score = 67.0 bits (162), Expect = 7e-11
Identities = 34/81 (41%), Positives = 46/81 (56%), Gaps = 7/81 (8%)
Query: 389 TNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN-C--FFCQPGNFHCKNNRCV 445
+NCT Q F C + C P +C+ + C +GSDE + C F CQPG F C C
Sbjct: 3315 SNCTASQ---FRC-KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCA 3370
Query: 446 FESWVCDSQDDCGDGSDEENC 466
+++CD ++DCGD SDE NC
Sbjct: 3371 LPAFICDGENDCGDNSDELNC 3391
Score = 65.9 bits (159), Expect = 2e-10
Identities = 37/105 (35%), Positives = 52/105 (49%), Gaps = 20/105 (19%)
Query: 142 SEEPN------CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 195
S+EP+ C +F+CG G C A+ C+ ++CGD+SDE C
Sbjct: 3346 SDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHV---------- 3395
Query: 196 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 240
C QF+C TK C+P +L+C+G DC D DE DC +C
Sbjct: 3396 CLSGQFKC----TKNQKCIPVNLRCNGQDDCGDEEDERDCPENSC 3436
Score = 57.8 bits (138), Expect = 4e-08
Identities = 34/104 (32%), Positives = 45/104 (43%), Gaps = 22/104 (21%)
Query: 369 CYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN 428
C T+ C+ Y EF C NG C C+ HC + SDEK
Sbjct: 2503 CVTKNSSCNAY-----------------SEFECG-NGECIDYQLTCDGIPHCKDKSDEKL 2544
Query: 429 CFF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPV 468
+ C+ G C N RC+ +CD ++DCGD SDE +C V
Sbjct: 2545 LYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKV 2588
Score = 56.6 bits (135), Expect = 9e-08
Identities = 43/126 (34%), Positives = 53/126 (42%), Gaps = 36/126 (28%)
Query: 141 KSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 200
KS E +C F C NG+CIP C+N D+CGD SDE C +
Sbjct: 2885 KSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDERNC-----------------HI 2927
Query: 201 FQCLSRFTKVYTC------LPESLKC---------DGNIDCLDLGDEIDCDVPTCGQWLK 245
+CLS+ KV C LP S KC D C+D+ DE P C Q
Sbjct: 2928 NECLSK--KVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDI-DECSSGFP-CSQQCI 2983
Query: 246 YFYGTF 251
YGT+
Sbjct: 2984 NTYGTY 2989
Score = 52.0 bits (123), Expect = 2e-06
Identities = 29/92 (31%), Positives = 38/92 (41%), Gaps = 11/92 (11%)
Query: 386 RDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF---------CQPGN 436
R + MC+ CS + P C ++ + C F C+ G
Sbjct: 790 RKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEALPHICKAGE 849
Query: 437 FHCKNNRCVFESWVCDSQDDCGDGSDEE--NC 466
F CKN C+ W CD DDC DGSDE+ NC
Sbjct: 850 FRCKNRHCIQARWKCDGDDDCLDGSDEDSVNC 881
Score = 50.4 bits (119), Expect = 7e-06
Identities = 30/87 (34%), Positives = 41/87 (47%), Gaps = 3/87 (3%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA-AFQPCAYNQFQCLS 205
C D+F C N KCIP +C+ +D+CGD SDE+ C T PC + + C
Sbjct: 3762 CKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAY-CNQ 3820
Query: 206 RFTKVY-TCLPESLKCDGNIDCLDLGD 231
T V+ C P + N C DL +
Sbjct: 3821 IKTSVFCRCKPGFQRNMKNRQCEDLNE 3847
Score = 49.3 bits (116), Expect = 1e-05
Identities = 32/111 (28%), Positives = 45/111 (40%), Gaps = 18/111 (16%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT-MCQKEEFPCS------RNGVCY 408
C E C Q +CDG + CP+ DE C+ E C+ +NG C
Sbjct: 2845 CGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCI 2904
Query: 409 PRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGD 459
P C+ ++ C +GSDE+NC N C+ + V DC D
Sbjct: 2905 PSGGLCDNKDDCGDGSDERNCHI----------NECLSKK-VSGCSQDCQD 2944
Score = 47.4 bits (111), Expect = 6e-05
Identities = 36/101 (35%), Positives = 45/101 (44%), Gaps = 24/101 (23%)
Query: 142 SEEPNC-----ACD---QFRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKE-ANPPTAA 191
S+E C CD +F C G+CI +AW C+ +C D SDE+ C PP
Sbjct: 1083 SDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK-- 1140
Query: 192 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDE 232
PCA + CL PE L C+G DC D DE
Sbjct: 1141 --HPCANDTSVCLQ---------PEKL-CNGKKDCPDGSDE 1169
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/109 (27%), Positives = 45/109 (41%), Gaps = 9/109 (8%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGV-------CY 408
C P E C + C ++ CDG CP+ DE+ T ++ E C N + C
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 409 PRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDC 457
S CN CP+G DE CQ +C+ C ++ + + C
Sbjct: 92 HLSQLCNGVLDCPDGYDEG--VHCQELLSNCQQLNCQYKCTMVRNSTRC 138
Score = 44.3 bits (103), Expect = 5e-04
Identities = 19/39 (48%), Positives = 24/39 (61%), Gaps = 3/39 (7%)
Query: 432 CQPGNFHCKNN-RCVFESWVCDSQDDCGDGSDE--ENCP 467
C PG F C ++ CV +SW+CD DC D SDE + CP
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCP 70
Score = 41.2 bits (95), Expect = 0.004
Identities = 26/79 (32%), Positives = 35/79 (44%), Gaps = 8/79 (10%)
Query: 393 MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEK--NC-----FFCQPGNFHC-KNNRC 444
+C EF C + C +S C+ CP+ SDE C C + C N+C
Sbjct: 31 LCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKC 90
Query: 445 VFESWVCDSQDDCGDGSDE 463
V S +C+ DC DG DE
Sbjct: 91 VHLSQLCNGVLDCPDGYDE 109
Score = 39.7 bits (91), Expect = 0.012
Identities = 26/89 (29%), Positives = 38/89 (42%), Gaps = 14/89 (15%)
Query: 147 CACDQFRCGNG-KCIPEAWKCNNMDECGDSSDEEI--CAKEANPPTAAAFQPCAYNQFQC 203
C +F C + C+ ++W C+ +C D SDE + C +E C N C
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVE-------IKCPLNHIAC 84
Query: 204 LSRFTKVYTCLPESLKCDGNIDCLDLGDE 232
L C+ S C+G +DC D DE
Sbjct: 85 LG----TNKCVHLSQLCNGVLDCPDGYDE 109
Score = 30.4 bits (67), Expect = 7.1
Identities = 32/145 (22%), Positives = 54/145 (37%), Gaps = 19/145 (13%)
Query: 144 EPNCACDQFRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 202
E C + C G KC+ + CN + +C D DE + +E C Q
Sbjct: 74 EIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQE-------LLSNC--QQLN 124
Query: 203 CLSRFTKVYTCLPESLKCDGNIDCLDLG----DEIDCDV-PTCGQWLKYFYGTFNSPNYP 257
C + T V C+ + + G D+ +C V TC Q + +G++
Sbjct: 125 CQYKCTMVRN--STRCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVE 182
Query: 258 DF--YPPGSNCTWLIDTGDHRKVIL 280
+ P +C I+ D ++L
Sbjct: 183 GYLMQPDNRSCKAKIEPTDRPPILL 207
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 126 bits (316), Expect = 1e-28
Identities = 89/342 (26%), Positives = 128/342 (37%), Gaps = 82/342 (23%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
C F C NG+C+P + C+ +D+C D+SDE++C N +++AF C + +
Sbjct: 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF-TCGHGE------ 1078
Query: 207 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 266
C+P +CD DC+D DE +C L Y N +
Sbjct: 1079 ------CIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCI--------SK 1124
Query: 267 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 326
W+ DT + DG +E + ++ T
Sbjct: 1125 NWVCDTDN----------------------DCGDGSDEK-----------NCNSTETCQP 1151
Query: 327 SSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRC---------- 376
S H C D G D C+ G C Q +C
Sbjct: 1152 SQFNCPNHRCIDLSFVCDG-------DKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVT 1204
Query: 377 ---DGYWHCPNGRDETNCT-----MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKN 428
DG + C + DE C MC +EF C +G+C P C+ C GSDE N
Sbjct: 1205 NRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHN 1264
Query: 429 CFF---CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 467
C FHC N C+ +W+CD +DCGD SDE++CP
Sbjct: 1265 ACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCP 1306
Score = 123 bits (308), Expect = 8e-28
Identities = 101/337 (29%), Positives = 136/337 (40%), Gaps = 68/337 (20%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
C QFRC NG+CIP+AWKC+ ++CGD SDE I ++A + +F C +
Sbjct: 3635 CRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPI-----EECMSSAHLCDNFTEFSCKTN 3689
Query: 207 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 266
Y C+P+ C+G DC D DE C+ TC + G F N+ P C
Sbjct: 3690 ----YRCIPKWAVCNGVDDCRDNSDEQGCEERTC-----HPVGDFRCKNH-HCIPLRWQC 3739
Query: 267 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 326
D GD+ EEN R T +
Sbjct: 3740 DGQNDCGDNSD-------------------------EENCAP--RECTESEFRCVNQQCI 3772
Query: 327 SSGQIRVHF--CADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPN 384
S I H+ C D + T C P C C + +CDG C +
Sbjct: 3773 PSRWICDHYNDCGDNSDERDCEMRT------CHPEYFQCTSGH-CVHSELKCDGSADCLD 3825
Query: 385 GRDETNC-------TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFC----- 432
DE +C CQ F C +N VC P +C+ + C +GSDE+ C
Sbjct: 3826 ASDEADCPTRFPDGAYCQATMFEC-KNHVCIPPYWKCDGDDDCGDGSDEE-LHLCLDVPC 3883
Query: 433 -QPGNFHCKNNRCVFESWVCDSQDDCGDGSD--EENC 466
P F C NNRC++ VC+ DDCGDG+D EE+C
Sbjct: 3884 NSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHC 3920
Score = 111 bits (278), Expect = 2e-24
Identities = 98/351 (27%), Positives = 139/351 (39%), Gaps = 86/351 (24%)
Query: 142 SEEPNC------ACDQFRCGNGKCIPEAWKCNNMDECGD--SSDEEICAKEANPPTAAAF 193
S+E C A +F C N +CIP + CN +D C D +SDE+ C
Sbjct: 2770 SDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRT-------- 2821
Query: 194 QPCAYNQFQCLSRFTKVYT---CLPESLKCDGNIDCLDLGDE--IDCDVPTC-------- 240
C S +TK + C+P CDG+ DC D DE C TC
Sbjct: 2822 ---------CQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCA 2872
Query: 241 -GQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIY 299
G+ + + + D ++C H + +FK DG I
Sbjct: 2873 SGRCIPQHWYCDQETDCFDASDEPASC-------GHSERTCLADEFKCDGGRCIPSEWIC 2925
Query: 300 DGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ--VDGFCL 357
DG + S + + H C ++ + F D C+
Sbjct: 2926 DGDND-------------------CGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCI 2966
Query: 358 PWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET-NCT--MCQKEEFPCSRNGVCYPRSDRC 414
P +W C DG C +G DE NCT C + EF C G+C P+ RC
Sbjct: 2967 P------QSWVC-------DGDVDCTDGYDENQNCTRRTCSENEFTCG-YGLCIPKIFRC 3012
Query: 415 NYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 463
+ N C + SDE+ C + CQ F C+N RC+ +++VCD +DCGDGSDE
Sbjct: 3013 DRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDE 3063
Score = 109 bits (272), Expect = 1e-23
Identities = 112/401 (27%), Positives = 142/401 (35%), Gaps = 92/401 (22%)
Query: 133 FRLAYFSGKSE-EPNCACDQFRCGNG-KCIPEAWKCNNMDECGDSSDE------------ 178
FR SG + P C+ QF C N KCIP WKC+ +C D SDE
Sbjct: 3497 FRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLG 3556
Query: 179 -------------EICAKEANPPTAA-------AFQPCAYNQFQCLSRFTKVYTCLPESL 218
+C N P + C N++QC ++ C+PES
Sbjct: 3557 QFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANK-----RCIPESW 3611
Query: 219 KCDGNIDCLDLGDEID--CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHR 276
+CD DC D DE C TC G F N P C D GDH
Sbjct: 3612 QCDTFNDCEDNSDEDSSHCASRTCRP------GQFRCAN-GRCIPQAWKCDVDNDCGDHS 3664
Query: 277 KVILR-----------FTDFKLDGT-----------GYGDYVKIYD--GLEENPHKLLRV 312
+ FT+F G D D G EE +
Sbjct: 3665 DEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGD 3724
Query: 313 LTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTE 372
+ H GQ +D+ N A C E C N C
Sbjct: 3725 FRCKNHHCIPLRWQCDGQNDCGDNSDEENCA---------PRECTESEFRCV-NQQCIPS 3774
Query: 373 QQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC- 429
+ CD Y C + DE +C M C E F C+ +G C +C+ C + SDE +C
Sbjct: 3775 RWICDHYNDCGDNSDERDCEMRTCHPEYFQCT-SGHCVHSELKCDGSADCLDASDEADCP 3833
Query: 430 ------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEE 464
+CQ F CKN+ C+ W CD DDCGDGSDEE
Sbjct: 3834 TRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEE 3874
Score = 103 bits (258), Expect = 5e-22
Identities = 96/327 (29%), Positives = 133/327 (40%), Gaps = 59/327 (18%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
C+ F CG+G+CIP W+C+ ++C D SDE C PT A C Q+ C +
Sbjct: 1067 CSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNC------PTHAPAS-CLDTQYTCDN- 1118
Query: 207 FTKVYTCLPESLKCDGNIDCLDLGDEIDCD-VPTCGQWLKYFYGTFNSPNYPDFYPPGSN 265
+ C+ ++ CD + DC D DE +C+ TC FN PN
Sbjct: 1119 ----HQCISKNWVCDTDNDCGDGSDEKNCNSTETCQP------SQFNCPN---------- 1158
Query: 266 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 325
HR + L F G D V DG +E L + F + +
Sbjct: 1159 ---------HRCIDLSFVC-----DGDKDCV---DGSDEVGCVLNCTASQFKCASGDKCI 1201
Query: 326 SSSGQIRVHF-CADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPN 384
+ + F C+D + A + G C E C + C CDG+ C
Sbjct: 1202 GVTNRCDGVFDCSDNSDEA---GCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLY 1258
Query: 385 GRDETNCTM---CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC----FFCQPGNF 437
G DE N + C F C NG C R+ C+ N C + SDEK+C F C +
Sbjct: 1259 GSDEHNACVPKTCPSSYFHCD-NGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQW 1317
Query: 438 HCK-NNRCVFESWVCDSQDDCGDGSDE 463
C +N CV S VCD DC +G+DE
Sbjct: 1318 QCLGHNICVNLSVVCDGIFDCPNGTDE 1344
Score = 102 bits (254), Expect = 1e-21
Identities = 45/104 (43%), Positives = 60/104 (57%), Gaps = 4/104 (3%)
Query: 366 NWGCYTEQQRCDGYWHCPNGRDETNCT-MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGS 424
N CY Q+CD C + DE NCT +C EF C NG C PR+ C++ N C +GS
Sbjct: 154 NGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCG-NGECIPRAYVCDHDNDCQDGS 212
Query: 425 DEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
DE C + C F C + RC++++WVCD +DDC D DE+ C
Sbjct: 213 DEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGC 256
Score = 81.3 bits (199), Expect = 4e-15
Identities = 45/130 (34%), Positives = 62/130 (47%), Gaps = 14/130 (10%)
Query: 349 TYQVDG--FCLPW----EIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT---MCQKEEF 399
T Q+ G +C+P + C N C +CDG C +G DE C+ +F
Sbjct: 3499 TLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQF 3558
Query: 400 PCSRNGVCYPRSDRCNYQNHCPNGSDEKNCF----FCQPGNFHCKNNRCVFESWVCDSQD 455
CS +G C CN +CP+GSDE C + C N RC+ ESW CD+ +
Sbjct: 3559 QCS-DGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFN 3617
Query: 456 DCGDGSDEEN 465
DC D SDE++
Sbjct: 3618 DCEDNSDEDS 3627
Score = 80.1 bits (196), Expect = 8e-15
Identities = 44/111 (39%), Positives = 58/111 (52%), Gaps = 10/111 (9%)
Query: 366 NWGCYTEQQRCDGYWHCPNGRDETN--CTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCP 421
N C +E+ +CD C +G DE C + C F C+ NG C S RC+Y N C
Sbjct: 2709 NGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCA-NGRCVQYSYRCDYYNDCG 2767
Query: 422 NGSDEKNCFF--CQ-PGNFHCKNNRCVFESWVCDSQDDCGDG--SDEENCP 467
+GSDE C F C F C N RC+ ++C+ D+C D SDE+NCP
Sbjct: 2768 DGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCP 2818
Score = 79.0 bits (193), Expect = 2e-14
Identities = 41/110 (37%), Positives = 52/110 (47%), Gaps = 5/110 (4%)
Query: 366 NWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 423
N C + +CDG C + DE NC C + EF C N C P C++ N C +
Sbjct: 3729 NHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCV-NQQCIPSRWICDHYNDCGDN 3787
Query: 424 SDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 471
SDE++C C P F C + CV CD DC D SDE +CP P
Sbjct: 3788 SDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFP 3837
Score = 75.1 bits (183), Expect = 3e-13
Identities = 48/159 (30%), Positives = 73/159 (45%), Gaps = 19/159 (11%)
Query: 85 NLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEE 144
N + T T + E A G IP + Q+ F + D + G E
Sbjct: 2855 NPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDC--FDASDEPASCGH---------SE 2903
Query: 145 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
C D+F+C G+CIP W C+ ++CGD SDE+ + N Q C+ ++F C+
Sbjct: 2904 RTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQN-------QNCSDSEFLCV 2956
Query: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDE-IDCDVPTCGQ 242
+ C+P+S CDG++DC D DE +C TC +
Sbjct: 2957 NDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSE 2995
Score = 73.9 bits (180), Expect = 6e-13
Identities = 83/323 (25%), Positives = 110/323 (34%), Gaps = 114/323 (35%)
Query: 142 SEEPNC---ACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 198
++E +C C+Q C NG C + KC+ +C DSSDE C + C +
Sbjct: 137 ADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCT-----------EICLH 185
Query: 199 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPD 258
N+F C + C+P + CD + DC D DE C+ PTCG +
Sbjct: 186 NEFSCGNG-----ECIPRAYVCDHDNDCQDGSDEHACNYPTCGGY--------------Q 226
Query: 259 FYPPGSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTA 315
F P C W+ D D D K +G DG E PH
Sbjct: 227 FTCPSGRCIYQNWVCDGED---------DCKDNGD--------EDGCESGPHD------- 262
Query: 316 FDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQR 375
VH C+ + W P G C + +
Sbjct: 263 -----------------VHKCSPR------------------EWSCPESGR--CISIYKV 285
Query: 376 CDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNH-CPNGSDEKNCFFCQP 434
CDG CP DE N + + CS +C + C YQ H P G FC P
Sbjct: 286 CDGILDCPGREDENNTSTGKY----CSMT-LC--SALNCQYQCHETPYG----GACFCPP 334
Query: 435 GNFHCKNNRCVFESWVCDSQDDC 457
G N +S C DDC
Sbjct: 335 GYIINHN-----DSRTCVEFDDC 352
Score = 73.6 bits (179), Expect = 7e-13
Identities = 51/166 (30%), Positives = 70/166 (42%), Gaps = 22/166 (13%)
Query: 322 LTVVSSSGQIRVHFCADKVNAARGFNATYQ-------VDGFCLP---WEIPCGGNWGCYT 371
+TV+ S +H + VN G NA Q FC P ++ CG +G
Sbjct: 947 MTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRL 1006
Query: 372 EQQR--CDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 429
C+G + +E C FPC +NG C P C+ + C + SDE+ C
Sbjct: 1007 ASNHLTCEG-----DPTNEPPTEQCGLFSFPC-KNGRCVPNYYLCDGVDDCHDNSDEQLC 1060
Query: 430 FF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 471
C F C + C+ W CD ++DC DGSDE NCP P
Sbjct: 1061 GTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAP 1106
Score = 72.8 bits (177), Expect = 1e-12
Identities = 40/117 (34%), Positives = 51/117 (43%), Gaps = 4/117 (3%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET-NCTM--CQKEEFPCSRNGVCYPRSD 412
C C C CD C +G DE +C+ C + CS NG C P
Sbjct: 67 CQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCS-NGQCIPSEY 125
Query: 413 RCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 469
RC++ CP+G+DE +C + C N C S CD + DC D SDE NC I
Sbjct: 126 RCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEI 182
Score = 72.4 bits (176), Expect = 2e-12
Identities = 39/97 (40%), Positives = 46/97 (47%), Gaps = 8/97 (8%)
Query: 377 DGYWHCPNGRDET---NCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF-- 431
+G W+ N R N C F CS NG C +C+ N C +GSDE
Sbjct: 2680 EGNWYLANNRKHCIVDNGERCGASSFTCS-NGRCISEEWKCDNDNDCGDGSDEMESVCAL 2738
Query: 432 --CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
C P F C N RCV S+ CD +DCGDGSDE C
Sbjct: 2739 HTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGC 2775
Score = 71.6 bits (174), Expect = 3e-12
Identities = 84/345 (24%), Positives = 117/345 (33%), Gaps = 74/345 (21%)
Query: 148 ACDQFRCGNGKCIPEAWKCNNMDE-CGDSSDEEICAK----EANPPTAAAFQPCAYNQFQ 202
AC+Q NG C + N CG + + E +P + C F
Sbjct: 973 ACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFP 1032
Query: 203 CLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 262
C K C+P CDG DC D DE C GT N+
Sbjct: 1033 C-----KNGRCVPNYYLCDGVDDCHDNSDEQLC-------------GTLNN--------- 1065
Query: 263 GSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL 322
C+ T H + I ++ D DG +E+ +HAP
Sbjct: 1066 --TCSSSAFTCGHGECIP--AHWRCDKRN-----DCVDGSDEHN---------CPTHAPA 1107
Query: 323 TVVSSSGQIRVHFCADKV------------NAARGFNATYQVDGFCLPWEIPCGGNWGCY 370
+ + + H C K + + N+T C P + C N C
Sbjct: 1108 SCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTET----CQPSQFNCP-NHRCI 1162
Query: 371 TEQQRCDGYWHCPNGRDETNCTM-CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 429
CDG C +G DE C + C +F C+ C ++RC+ C + SDE C
Sbjct: 1163 DLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC 1222
Query: 430 -----FFCQPGNFHCKNNR-CVFESWVCDSQDDCGDGSDEENCPV 468
C F C+ + C+ W CD DC GSDE N V
Sbjct: 1223 PTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACV 1267
Score = 69.7 bits (169), Expect = 1e-11
Identities = 69/303 (22%), Positives = 98/303 (32%), Gaps = 69/303 (22%)
Query: 139 SGKSEEPNCA---CDQ--FRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAA 192
S ++E CA C Q F+C G+CIP +W C+ +C D SDE ++
Sbjct: 54 SDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQST------ 107
Query: 193 FQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFN 252
C+ +Q C + C+P +CD DC D DE DC PTC Q +N
Sbjct: 108 ---CSSHQITCSNG-----QCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYN 159
Query: 253 SPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRV 312
+ C W +D D I
Sbjct: 160 T---------SQKCDWKVDCRDSSDEI--------------------------------N 178
Query: 313 LTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTE 372
T H + + R + C + G + C ++ C C +
Sbjct: 179 CTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSG-RCIYQ 237
Query: 373 QQRCDGYWHCPNGRDETNCT-------MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSD 425
CDG C + DE C C E+ C +G C C+ CP D
Sbjct: 238 NWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRED 297
Query: 426 EKN 428
E N
Sbjct: 298 ENN 300
Score = 68.6 bits (166), Expect = 2e-11
Identities = 41/121 (33%), Positives = 54/121 (44%), Gaps = 10/121 (8%)
Query: 353 DGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDE--TNCTM--CQKEEFPCSRNGVCY 408
D C C + C CDG C + DE T CT C EF C+ +G C
Sbjct: 2819 DRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCA-SGRCI 2877
Query: 409 PRSDRCNYQNHCPNGSDEK-NCFF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 463
P+ C+ + C + SDE +C C F C RC+ W+CD +DCGD SDE
Sbjct: 2878 PQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDE 2937
Query: 464 E 464
+
Sbjct: 2938 D 2938
Score = 63.5 bits (153), Expect = 8e-10
Identities = 30/90 (33%), Positives = 47/90 (52%), Gaps = 14/90 (15%)
Query: 146 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 205
+C Q+ C N +CI + W C+ ++CGD SDE+ C + + C +QF C +
Sbjct: 1108 SCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNC---------NSTETCQPSQFNCPN 1158
Query: 206 RFTKVYTCLPESLKCDGNIDCLDLGDEIDC 235
+ C+ S CDG+ DC+D DE+ C
Sbjct: 1159 -----HRCIDLSFVCDGDKDCVDGSDEVGC 1183
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/98 (33%), Positives = 49/98 (50%), Gaps = 19/98 (19%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
C+ ++F CG G CIP+ ++C+ ++CGD SDE C +Q C NQF C +
Sbjct: 2993 CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGC----------LYQTCQQNQFTCQNG 3042
Query: 207 FTKVYTCLPESLKCDGNIDCLDLGDEI----DCDVPTC 240
C+ ++ CD + DC D DE+ PTC
Sbjct: 3043 -----RCISKTFVCDEDNDCGDGSDELMHLCHTPEPTC 3075
Score = 61.6 bits (148), Expect = 3e-09
Identities = 30/73 (41%), Positives = 38/73 (52%), Gaps = 4/73 (5%)
Query: 394 CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKN-NRCVFESWV 450
C F C +G C P RC+ C + +DE C CQ G F C++ +C+ SWV
Sbjct: 28 CDSAHFRCG-SGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWV 86
Query: 451 CDSQDDCGDGSDE 463
CD DC DGSDE
Sbjct: 87 CDQDQDCDDGSDE 99
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/97 (37%), Positives = 50/97 (51%), Gaps = 13/97 (13%)
Query: 146 NCACDQFRCGNG-KCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
NC QF+C +G KCI +C+ + +C D+SDE C PP C ++FQC
Sbjct: 1186 NCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCP--TRPPGM-----CHSDEFQC- 1237
Query: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVP-TC 240
+ C+P +CDG+ DCL DE + VP TC
Sbjct: 1238 ---QEDGICIPNFWECDGHPDCLYGSDEHNACVPKTC 1271
Score = 58.5 bits (140), Expect = 2e-08
Identities = 37/100 (37%), Positives = 48/100 (48%), Gaps = 17/100 (17%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP--CAYNQFQCL 204
C F C NG CI AW C+ ++CGD SDE+ C PT QP C Q+QCL
Sbjct: 1271 CPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDC------PT----QPFRCPSWQWQCL 1320
Query: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEID-CDVPTCGQW 243
C+ S+ CDG DC + DE C+ +C +
Sbjct: 1321 GH----NICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDF 1356
Score = 57.8 bits (138), Expect = 4e-08
Identities = 32/89 (35%), Positives = 46/89 (51%), Gaps = 14/89 (15%)
Query: 150 DQFRCGNGKCIPEAWKCNNMDECGDSSDE--EICAKEANPPTAAAFQPCAYNQFQCLSRF 207
++FRC N +CI CN +D+CGD +DE E C K PT +PC +++C +
Sbjct: 3887 NRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRK----PTP---KPCTEYEYKCGNGH 3939
Query: 208 TKVYTCLPESLKCDGNIDCLDLGDEIDCD 236
C+P CD DC D DE+ C+
Sbjct: 3940 -----CIPHDNVCDDADDCGDWSDELGCN 3963
Score = 55.8 bits (133), Expect = 2e-07
Identities = 38/114 (33%), Positives = 49/114 (42%), Gaps = 16/114 (14%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPC-AYNQFQCLS 205
C F C N CIP WKC+ D+CGD SDEE+ PC + N+F+C +
Sbjct: 3842 CQATMFECKNHVCIPPYWKCDGDDDCGDGSDEEL--------HLCLDVPCNSPNRFRCDN 3893
Query: 206 RFTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTCGQWLKYFYGTFNSPNYP 257
C+ C+G DC D DE + C PT +Y Y N P
Sbjct: 3894 N-----RCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIP 3942
Score = 55.1 bits (131), Expect = 3e-07
Identities = 34/103 (33%), Positives = 46/103 (44%), Gaps = 9/103 (8%)
Query: 362 PCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQK-EEFPCSRNGVCYPRSDRCNYQNHC 420
P G N ++Q+C+ NG C E C G Y ++R HC
Sbjct: 2637 PRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNR----KHC 2692
Query: 421 PNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 463
+ E+ C +F C N RC+ E W CD+ +DCGDGSDE
Sbjct: 2693 IVDNGER----CGASSFTCSNGRCISEEWKCDNDNDCGDGSDE 2731
Score = 55.1 bits (131), Expect = 3e-07
Identities = 38/127 (29%), Positives = 57/127 (44%), Gaps = 11/127 (8%)
Query: 144 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICA-KEANPPTAAAFQPCAYNQFQ 202
EP C +F+C NG+CI CN++D+C D+SDE+ C E + P+ + C +N
Sbjct: 3072 EPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISG---CDHN--- 3125
Query: 203 CLSRFTKVY-TCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFY- 260
C T Y +C P C+D+ DE C Q + G++ P +
Sbjct: 3126 CTDTLTSFYCSCRPGYKLMSDKRTCVDI-DECTEMPFVCSQKCENVIGSYICKCAPGYLR 3184
Query: 261 -PPGSNC 266
P G C
Sbjct: 3185 EPDGKTC 3191
Score = 44.7 bits (104), Expect = 4e-04
Identities = 22/54 (40%), Positives = 28/54 (51%)
Query: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPTRVITAAVIGSLIC 485
C +F CKN RCV ++CD DDC D SDE+ C + T +A G C
Sbjct: 1026 CGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGEC 1079
Score = 44.3 bits (103), Expect = 5e-04
Identities = 18/37 (48%), Positives = 24/37 (64%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAK 183
C +++CGNG CIP C++ D+CGD SDE C K
Sbjct: 3928 CTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNK 3964
Score = 41.2 bits (95), Expect = 0.004
Identities = 14/38 (36%), Positives = 19/38 (50%)
Query: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 469
C +F C + C+ W CD DC D +DE C V+
Sbjct: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV 65
Score = 39.7 bits (91), Expect = 0.012
Identities = 26/81 (32%), Positives = 33/81 (40%), Gaps = 11/81 (13%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET---NCTMCQKEEFPCSRNGVCYPRSD 412
C W+ C G+ C CDG + CPNG DE+ N C C+ V P
Sbjct: 1312 CPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGA 1371
Query: 413 RCNYQNHCPNG----SDEKNC 429
+C CP G +D K C
Sbjct: 1372 KC----LCPLGFLLANDSKTC 1388
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 124 bits (311), Expect = 4e-28
Identities = 99/356 (27%), Positives = 138/356 (38%), Gaps = 82/356 (23%)
Query: 143 EEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 202
E C D++ C +G CI +W C+ ++C D SDE C A + C + FQ
Sbjct: 1154 EMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCT--------AIYHTCEASNFQ 1205
Query: 203 CLSRFTKVYTCLPESLKCDGNIDCLDLGDE--IDCDVPTCGQWLKYFYGTFNSPNYPDFY 260
C + C+P+ CDG+ DC D DE ++C+ G F PN
Sbjct: 1206 CRNGH-----CIPQRWACDGDTDCQDGSDEDPVNCEKKCNG---------FRCPN-GTCI 1250
Query: 261 PPGSNCTWLIDTGDH------RKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 314
P +C L D D + F DF R
Sbjct: 1251 PSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKN---------------------RQQC 1289
Query: 315 AFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQ 374
F S + G I+ +D+ A G + + C + C N C +
Sbjct: 1290 LFHS------MVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQ-NGVCISLIW 1342
Query: 375 RCDGYWHCPNGRDETNCTMCQKEEFP-CSR-------NGVCYPRSDRCNYQNHCPNGSDE 426
+CDG C + DE NC E P CSR NG C P +C+ +N C + SDE
Sbjct: 1343 KCDGMDDCGDYSDEANCE--NPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
Query: 427 KNC-------------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 469
K+C C P + C + CV ++WVCD DC DGSDEE CP++
Sbjct: 1401 KDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLL 1456
Score = 118 bits (295), Expect = 3e-26
Identities = 97/368 (26%), Positives = 145/368 (39%), Gaps = 58/368 (15%)
Query: 131 KGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTA 190
+G++L + EE C +Q+RC NG CI W C+ ++CGD SDE C P T
Sbjct: 1062 QGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC-----PTTI 1116
Query: 191 AAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC---------G 241
QF+C + TC+P S KCD DC D DE C++ C G
Sbjct: 1117 CDLD----TQFRC----QESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSG 1168
Query: 242 QWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDG 301
++ + + D + +NCT + T + R DG
Sbjct: 1169 MCIRSSWVCDGDNDCRD-WSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDG 1227
Query: 302 LEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPW-E 360
+E+P + F + SS + C+D + + C + +
Sbjct: 1228 SDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDG-------SDEQHCEPLCTHFMD 1280
Query: 361 IPCGGNWGCYTEQQRCDGYWHCPNGRDE----TNCT-------MCQKEEFPCSRNGVCYP 409
C C CDG C +G DE C+ +C + F C +NGVC
Sbjct: 1281 FVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQC-QNGVCIS 1339
Query: 410 RSDRCNYQNHCPNGSDEKNC-----------FFCQPGNFHCKNNRCVFESWVCDSQDDCG 458
+C+ + C + SDE NC +F F C+N C+ W CD ++DCG
Sbjct: 1340 LIWKCDGMDDCGDYSDEANCENPTEAPNCSRYF----QFRCENGHCIPNRWKCDRENDCG 1395
Query: 459 DGSDEENC 466
D SDE++C
Sbjct: 1396 DWSDEKDC 1403
Score = 111 bits (278), Expect = 2e-24
Identities = 91/307 (29%), Positives = 116/307 (37%), Gaps = 80/307 (26%)
Query: 136 AYFSGKSEEPNC--ACDQF--RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA 191
A F+G S++P CD+F +C NG CI WKC+ MD+CGD SDE C P +
Sbjct: 1310 AAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCS 1369
Query: 192 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTF 251
Y QF+C + C+P KCD DC D DE DC + F
Sbjct: 1370 -----RYFQFRCENGH-----CIPNRWKCDRENDCGDWSDEKDCG----DSHILPFSTPG 1415
Query: 252 NSPNYPDFYPPGSNC----TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPH 307
S P++Y S TW+ D GY D DG +E
Sbjct: 1416 PSTCLPNYYRCSSGTCVMDTWVCD-------------------GYRDCA---DGSDEEAC 1453
Query: 308 KLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNW 367
LL +TA + L G C +E C
Sbjct: 1454 PLLANVTAASTPTQL-------------------------------GRCDRFEFECHQPK 1482
Query: 368 GCYTEQQRCDGYWHCPNGRDETNC-----TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPN 422
C +RCDG+ C +GRDE NC C EF C C S+RC+ C +
Sbjct: 1483 TCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSD 1542
Query: 423 GSDEKNC 429
SDEK C
Sbjct: 1543 ESDEKAC 1549
Score = 87.4 bits (215), Expect = 5e-17
Identities = 45/131 (34%), Positives = 65/131 (49%), Gaps = 6/131 (4%)
Query: 347 NATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNC--TMCQKE-EFPCSR 403
N + + CL + C N C CD C + DE NC T+C + +F C
Sbjct: 1069 NTCVKEENTCLRNQYRCS-NGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQE 1127
Query: 404 NGVCYPRSDRCNYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGS 461
+G C P S +C+ ++ C + SDE +C C+ ++C + C+ SWVCD +DC D S
Sbjct: 1128 SGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWS 1187
Query: 462 DEENCPVIVPT 472
DE NC I T
Sbjct: 1188 DEANCTAIYHT 1198
Score = 70.9 bits (172), Expect = 5e-12
Identities = 42/132 (31%), Positives = 53/132 (40%), Gaps = 22/132 (16%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM---------------CQKEEFP 400
CLP C C + CDGY C +G DE C + C + EF
Sbjct: 1419 CLPNYYRCSSGT-CVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFE 1477
Query: 401 CSRNGVCYPRSDRCNYQNHCPNGSDEKNC-----FFCQPGNFHCKNNR-CVFESWVCDSQ 454
C + C P RC+ C +G DE NC C F C++ C+ S CD
Sbjct: 1478 CHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGF 1537
Query: 455 DDCGDGSDEENC 466
DC D SDE+ C
Sbjct: 1538 LDCSDESDEKAC 1549
Score = 42.0 bits (97), Expect = 0.002
Identities = 32/98 (32%), Positives = 39/98 (39%), Gaps = 33/98 (33%)
Query: 400 PCSRNGVCYP-----RSDRCNYQ---NHCPNGSDEKNCFFCQPGNFHCKNNRCVFES--- 448
PCS +C P RS RC + P+G +C P + KNN CV E
Sbjct: 1025 PCSL--LCLPKANNSRSCRCPEDVSSSVLPSGDLMCDC----PQGYQLKNNTCVKEENTC 1078
Query: 449 ----------------WVCDSQDDCGDGSDEENCPVIV 470
W CD +DCGD SDE NCP +
Sbjct: 1079 LRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTI 1116
Score = 34.3 bits (77), Expect = 0.49
Identities = 14/39 (35%), Positives = 24/39 (61%), Gaps = 1/39 (2%)
Query: 147 CACDQFRCGNGK-CIPEAWKCNNMDECGDSSDEEICAKE 184
C +F+C +G+ CI + +C+ +C D SDE+ C+ E
Sbjct: 1514 CMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDE 1552
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 121 bits (303), Expect = 3e-27
Identities = 97/345 (28%), Positives = 136/345 (39%), Gaps = 79/345 (22%)
Query: 145 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
P C +F C N +CI E WKC+ ++C D+SDE P C ++F+C
Sbjct: 852 PQCQPGEFACANSRCIQERWKCDGDNDCLDNSDEA--------PALCHQHTCPSDRFKCE 903
Query: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTCGQWLKYFYGTFNSPNYPDFYPP 262
+ C+P CDG+ DC + DE + C TC PN F
Sbjct: 904 NN-----RCIPNRWLCDGDNDCGNSEDESNATCSARTC------------PPN--QFSCA 944
Query: 263 GSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSH 319
C +W D D D +E+ A+ +
Sbjct: 945 SGRCIPISWTCDLDDD----------------------CGDRSDESAS------CAYPTC 976
Query: 320 APLTVVSSSGQ--IRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCD 377
PLT + + I +++ D N + C + C C E CD
Sbjct: 977 FPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCNSG-RCIPEHWTCD 1035
Query: 378 GYWHCPNGRDET--NCTM--------CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEK 427
G C + DET NCT C +EF C +G+C P RC+ C + SDEK
Sbjct: 1036 GDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEK 1095
Query: 428 NC----FFCQPG-NFHCKNN-RCVFESWVCDSQDDCGDGSDEENC 466
+C C P F CK++ RC+ ++WVCD +DC D SDEENC
Sbjct: 1096 SCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENC 1140
Score = 120 bits (300), Expect = 7e-27
Identities = 100/368 (27%), Positives = 139/368 (37%), Gaps = 75/368 (20%)
Query: 141 KSEEPNCACDQFRC-------GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAF 193
KS+E C+ RC NG+C+ CN D+CGD SDE C K A
Sbjct: 2553 KSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTA-------- 2604
Query: 194 QPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKY-FYGTFN 252
C +F+C TC+ S +C+ +DC D DE++C C + + G
Sbjct: 2605 --CGVGEFRCRDG-----TCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLF 2657
Query: 253 SP--NYPDFYPPGSNCTWLIDTGDH------------------------RKVILRFTDFK 286
P Y P C D GD+ R + + +T K
Sbjct: 2658 QPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDK 2717
Query: 287 LDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGF 346
D +G E+ H F S A + + C + G
Sbjct: 2718 EDDCEHG---------EDETH-----CNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGS 2763
Query: 347 NATYQVDG-FCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET---NC---TMCQKEEF 399
+ +G C P C G C E+ CDG C +G DE+ C + C EF
Sbjct: 2764 DEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREF 2823
Query: 400 PCSRNGVCYPRSDRCNYQNHCPNGSDEK-NCFF--CQPGNFHCKNNRCV-FESWVCDSQD 455
C +N C P+ C++ C +GSDE C + C P F C N RC+ W CD ++
Sbjct: 2824 MC-QNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGEN 2882
Query: 456 DCGDGSDE 463
DC D SDE
Sbjct: 2883 DCHDQSDE 2890
Score = 120 bits (300), Expect = 7e-27
Identities = 98/331 (29%), Positives = 134/331 (40%), Gaps = 52/331 (15%)
Query: 140 GKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN 199
G++ NC QF C N KCIP WKC+ D+CGD SDE PP F+ C
Sbjct: 3327 GRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDE--------PPDCPEFK-CRPG 3377
Query: 200 QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDF 259
QFQC + C + CDG+ DC D DE +CD+ C F T + P
Sbjct: 3378 QFQCSTGI-----CTNPAFICDGDNDCQDNSDEANCDIHVC--LPSQFKCTNTNRCIPGI 3430
Query: 260 YPPG--SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD 317
+ NC D D +V F+ T +++ +N
Sbjct: 3431 FRCNGQDNCGDGEDERDCPEVTCAPNQFQCSIT-KRCIPRVWVCDRDND-------CVDG 3482
Query: 318 SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCD 377
S P + + C D + R A ++ DG E CG G ++ CD
Sbjct: 3483 SDEPANCTQMTCGVDEFRCKD---SGRCIPARWKCDG-----EDDCGD--GSDEPKEECD 3532
Query: 378 GYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCF--FCQPG 435
E C + +F C +N C P +C+Y N C + SDE++C C
Sbjct: 3533 ----------ERTC---EPYQFRC-KNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCSES 3578
Query: 436 NFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
F C N RC+ W CD DC DGSDE++C
Sbjct: 3579 EFSCANGRCIAGRWKCDGDHDCADGSDEKDC 3609
Score = 85.5 bits (210), Expect = 2e-16
Identities = 47/133 (35%), Positives = 66/133 (49%), Gaps = 5/133 (3%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 413
C P++ C N C + +CD C + DE +CT C + EF C+ NG C +
Sbjct: 3536 CEPYQFRCKNN-RCVPGRWQCDYDNDCGDNSDEESCTPRPCSESEFSCA-NGRCIAGRWK 3593
Query: 414 CNYQNHCPNGSDEKNCF-FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVPT 472
C+ + C +GSDEK+C C F CK+ C+ W CD+ DC DGSDEE C V T
Sbjct: 3594 CDGDHDCADGSDEKDCTPRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRT 3653
Query: 473 RVITAAVIGSLIC 485
+ + +C
Sbjct: 3654 CPLDEFQCNNTLC 3666
Score = 84.7 bits (208), Expect = 3e-16
Identities = 46/118 (38%), Positives = 59/118 (50%), Gaps = 9/118 (7%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT-MCQKEEFPCSRNGVCYPRSDRC 414
C E C N C + +CDG C +G DE +CT C ++F C ++G C P RC
Sbjct: 3575 CSESEFSCA-NGRCIAGRWKCDGDHDCADGSDEKDCTPRCDMDQFQC-KSGHCIPLRWRC 3632
Query: 415 NYQNHCPNGSDEKNCFF----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE--ENC 466
+ C +GSDE+ C C F C N C +W CD +DDCGD SDE E C
Sbjct: 3633 DADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEEC 3690
Score = 82.0 bits (201), Expect = 2e-15
Identities = 46/125 (36%), Positives = 54/125 (43%), Gaps = 10/125 (8%)
Query: 347 NATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM----CQKEEFPCS 402
N +Y C P E C N C E+ +CDG C + DE C + F C
Sbjct: 845 NPSYVPPPQCQPGEFACA-NSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCE 903
Query: 403 RNGVCYPRSDRCNYQNHCPNGSDEKNCFF----CQPGNFHCKNNRCVFESWVCDSQDDCG 458
N C P C+ N C N DE N C P F C + RC+ SW CD DDCG
Sbjct: 904 NNR-CIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCG 962
Query: 459 DGSDE 463
D SDE
Sbjct: 963 DRSDE 967
Score = 77.8 bits (190), Expect = 4e-14
Identities = 40/106 (37%), Positives = 55/106 (51%), Gaps = 23/106 (21%)
Query: 142 SEEPNCACD-------QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ 194
S+EP CD QFRC N +C+P W+C+ ++CGD+SDEE C +
Sbjct: 3524 SDEPKEECDERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTP----------R 3573
Query: 195 PCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 240
PC+ ++F C + C+ KCDG+ DC D DE DC P C
Sbjct: 3574 PCSESEFSCANG-----RCIAGRWKCDGDHDCADGSDEKDC-TPRC 3613
Score = 75.1 bits (183), Expect = 3e-13
Identities = 43/116 (37%), Positives = 54/116 (46%), Gaps = 15/116 (12%)
Query: 366 NWGCYTEQQRCDGYWHCPNGRDETNC--TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 423
N C + C+G C +G DE C T C EF C R+G C S RCN C +
Sbjct: 2575 NGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRC-RDGTCIGNSSRCNQFVDCEDA 2633
Query: 424 SDEKNCFFCQPGNFH-----------C-KNNRCVFESWVCDSQDDCGDGSDEENCP 467
SDE NC ++ C + + C SWVCD +DCGD SDE +CP
Sbjct: 2634 SDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCP 2689
Score = 75.1 bits (183), Expect = 3e-13
Identities = 37/114 (32%), Positives = 51/114 (44%), Gaps = 16/114 (14%)
Query: 369 CYTEQQRCDGYWHCPNGRDETNCTMCQKEEF-----------PCSRNGVCYPRSDRCNYQ 417
C RC+ + C + DE NC+ + PC R +CY S C+
Sbjct: 2617 CIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGA 2676
Query: 418 NHCPNGSDEKNCFF-----CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
N C + SDE++C C F C + RC+ SW CD +DDC G DE +C
Sbjct: 2677 NDCGDYSDERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC 2730
Score = 73.6 bits (179), Expect = 7e-13
Identities = 43/126 (34%), Positives = 60/126 (47%), Gaps = 9/126 (7%)
Query: 347 NATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT----MCQKE-EFPC 401
N + G C E C + C + RCDG C + DE +C +C +F C
Sbjct: 1053 NQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGC 1112
Query: 402 SRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKNNR--CVFESWVCDSQDDC 457
+ C ++ C+ N C + SDE+NC C+P + C NN C+ +CD DDC
Sbjct: 1113 KDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDC 1172
Query: 458 GDGSDE 463
GDGSDE
Sbjct: 1173 GDGSDE 1178
Score = 73.6 bits (179), Expect = 7e-13
Identities = 49/142 (34%), Positives = 66/142 (46%), Gaps = 9/142 (6%)
Query: 334 HFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET-NCT 392
H CA N G + V C + C N C +CD C + DE +C
Sbjct: 3313 HKCACPTNFYLGSDGRTCVSN-CTASQFVCK-NDKCIPFWWKCDTEDDCGDHSDEPPDCP 3370
Query: 393 --MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKN-NRCVFE 447
C+ +F CS G+C + C+ N C + SDE NC C P F C N NRC+
Sbjct: 3371 EFKCRPGQFQCS-TGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPG 3429
Query: 448 SWVCDSQDDCGDGSDEENCPVI 469
+ C+ QD+CGDG DE +CP +
Sbjct: 3430 IFRCNGQDNCGDGEDERDCPEV 3451
Score = 68.9 bits (167), Expect = 2e-11
Identities = 34/88 (38%), Positives = 44/88 (50%), Gaps = 13/88 (14%)
Query: 145 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
P C DQF+C +G CIP W+C+ +C D SDEE C + C ++FQC
Sbjct: 3611 PRCDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEAC--------GTGVRTCPLDEFQCN 3662
Query: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDE 232
+ C P + KCDG DC D DE
Sbjct: 3663 NTL-----CKPLAWKCDGEDDCGDNSDE 3685
Score = 68.9 bits (167), Expect = 2e-11
Identities = 38/95 (40%), Positives = 49/95 (51%), Gaps = 15/95 (15%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDE--EICAKEANPPTAAAFQPCAYNQFQCL 204
C D+F+C N C P AWKC+ D+CGD+SDE E CA+ PP F+C
Sbjct: 3654 CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPN---------RPFRCK 3704
Query: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPT 239
+ CL +CDG +C D DE DC+ PT
Sbjct: 3705 ND----RVCLWIGRQCDGTDNCGDGTDEEDCEPPT 3735
Score = 68.2 bits (165), Expect = 3e-11
Identities = 45/144 (31%), Positives = 66/144 (45%), Gaps = 25/144 (17%)
Query: 360 EIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQK------EEFPCSRNGVCYPRSDR 413
E C N C +CDG C + DE N C + F C + VC +
Sbjct: 3658 EFQCN-NTLCKPLAWKCDGEDDCGDNSDE-NPEECARFVCPPNRPFRCKNDRVCLWIGRQ 3715
Query: 414 CNYQNHCPNGSDEKNCFFCQPGNFH-----------CKNNRCVFESWVCDSQDDCGDGSD 462
C+ ++C +G+DE++C +P H C+N RC+ S C+ DDCGDGSD
Sbjct: 3716 CDGTDNCGDGTDEEDC---EPPTAHTTHCKDKKEFLCRNQRCLSSSLRCNMFDDCGDGSD 3772
Query: 463 EENCPVIVPTRVITAAVIGSLICG 486
EE+C + +T+ + ICG
Sbjct: 3773 EEDCSI---DPKLTSCATNASICG 3793
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/96 (36%), Positives = 46/96 (47%), Gaps = 18/96 (18%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
C+ +F C NG+CI WKC+ +C D SDE+ C C +QFQC S
Sbjct: 3575 CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTPR-----------CDMDQFQCKSG 3623
Query: 207 FTKVYTCLPESLKCDGNIDCLDLGDEIDC--DVPTC 240
C+P +CD + DC+D DE C V TC
Sbjct: 3624 H-----CIPLRWRCDADADCMDGSDEEACGTGVRTC 3654
Score = 67.0 bits (162), Expect = 7e-11
Identities = 42/113 (37%), Positives = 50/113 (44%), Gaps = 8/113 (7%)
Query: 360 EIPCGGNWGCYTEQQRCDGYWHCPNGRDE----TNCTMCQKEEFPCSRNGVCYPRSDRCN 415
E C N C CDG HC + DE N C+K CS NG C CN
Sbjct: 2529 EFECA-NGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCS-NGRCVSNMLWCN 2586
Query: 416 YQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
+ C +GSDE C C G F C++ C+ S C+ DC D SDE NC
Sbjct: 2587 GADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNC 2639
Score = 66.2 bits (160), Expect = 1e-10
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 11/104 (10%)
Query: 139 SGKSEEPNCACDQFRCGNGKCI-PEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPC- 196
S + E P C +FRC NG+C+ W+C+ ++C D SDE NP + C
Sbjct: 2850 SPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE----APKNPHCTSQEHKCN 2905
Query: 197 AYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 240
A +QF C S C+ E+L C+G DC D DE C + C
Sbjct: 2906 ASSQFLCSSG-----RCVAEALLCNGQDDCGDSSDERGCHINEC 2944
Score = 65.9 bits (159), Expect = 2e-10
Identities = 42/121 (34%), Positives = 56/121 (46%), Gaps = 13/121 (10%)
Query: 362 PCG-GNWGCYTEQQRCDGYWH---CPN----GRDETNCTM-CQKEEFPCSRNGVCYPRSD 412
PC N GC G H CP G D C C +F C +N C P
Sbjct: 3293 PCKVNNGGCSNLCLLSPGGGHKCACPTNFYLGSDGRTCVSNCTASQFVC-KNDKCIPFWW 3351
Query: 413 RCNYQNHCPNGSDEK-NC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 469
+C+ ++ C + SDE +C F C+PG F C C +++CD +DC D SDE NC +
Sbjct: 3352 KCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIH 3411
Query: 470 V 470
V
Sbjct: 3412 V 3412
Score = 58.9 bits (141), Expect = 2e-08
Identities = 38/97 (39%), Positives = 48/97 (49%), Gaps = 13/97 (13%)
Query: 382 CPNGR---DETNC----TMCQ-KEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEK----NC 429
C GR D+ C + C+ ++EF C+ NG C S C+ HC + SDEK N
Sbjct: 2505 CRGGRILQDDLTCRAVNSSCRAQDEFECA-NGECINFSLTCDGVPHCKDKSDEKPSYCNS 2563
Query: 430 FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
C+ C N RCV C+ DDCGDGSDE C
Sbjct: 2564 RRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPC 2600
Score = 57.8 bits (138), Expect = 4e-08
Identities = 37/136 (27%), Positives = 54/136 (39%), Gaps = 45/136 (33%)
Query: 146 NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI--CAKEANPPTAAAFQPCAYNQFQC 203
+C+ QF+C +G+CIPE W C+ ++CGD SDE C +A P C ++FQC
Sbjct: 1014 SCSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCTNQATRPPGG----CHTDEFQC 1069
Query: 204 ---------------------------LSRFTKVYT------------CLPESLKCDGNI 224
T V C+ ++ CDG+
Sbjct: 1070 RLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDN 1129
Query: 225 DCLDLGDEIDCDVPTC 240
DC D DE +C+ C
Sbjct: 1130 DCEDNSDEENCESLAC 1145
Score = 57.8 bits (138), Expect = 4e-08
Identities = 40/106 (37%), Positives = 52/106 (49%), Gaps = 25/106 (23%)
Query: 142 SEEPNC-----ACD---QFRC-GNGKCIPEAWKCNNMDECGDSSDEEICAKEA-NPPTAA 191
S+E +C CD +F C + +CI +AW C+ ++C D+SDEE C A PP+
Sbjct: 1092 SDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPPS-- 1149
Query: 192 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID-CD 236
PCA N CLP CDGN DC D DE + CD
Sbjct: 1150 --HPCANN----------TSVCLPPDKLCDGNDDCGDGSDEGELCD 1183
Score = 54.7 bits (130), Expect = 4e-07
Identities = 42/150 (28%), Positives = 55/150 (36%), Gaps = 21/150 (14%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDE-------TNCTMCQKEEFPCSRNGVCY 408
C P + C C ++ RCDG CP+G DE + CQ E C +C
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 409 PRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFE--------SWVCDS----QDD 456
P S CN C +GSDE C+ +C C + C+S Q D
Sbjct: 87 PMSRLCNGVQDCMDGSDEGP--HCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQAD 144
Query: 457 CGDGSDEENCPVIVPTRVITAAVIGSLICG 486
D + C V + GS ICG
Sbjct: 145 GKTCKDFDECSVYGTCSQLCTNTDGSFICG 174
Score = 52.0 bits (123), Expect = 2e-06
Identities = 32/87 (36%), Positives = 43/87 (49%), Gaps = 10/87 (11%)
Query: 147 CACDQFRCGNG-KCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 205
C+ QF C + CI + W+C+ +C D SDE A E P + A Q C N+ CL
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDE---APEICPQSKA--QRCQPNEHNCLG 81
Query: 206 RFTKVYTCLPESLKCDGNIDCLDLGDE 232
C+P S C+G DC+D DE
Sbjct: 82 ----TELCVPMSRLCNGVQDCMDGSDE 104
Score = 52.0 bits (123), Expect = 2e-06
Identities = 69/261 (26%), Positives = 96/261 (36%), Gaps = 50/261 (19%)
Query: 142 SEEPNC-ACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN- 199
S+E C A QF C +G+C+ EA CN D+CGDSSDE C N + C+ +
Sbjct: 2899 SQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGC--HINECLSRKLSGCSQDC 2956
Query: 200 -----QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSP 254
F+C C P D C D+ DE P C Q +G++
Sbjct: 2957 EDLKIGFKC--------RCRPGFRLKDDGRTCADV-DECSTTFP-CSQRCINTHGSYKCL 3006
Query: 255 NYPDFYPPGS---NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLR 311
+ P G +C + D R+ KL+ G +Y + GL
Sbjct: 3007 CVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDG-SNYTLLKQGLNN------A 3059
Query: 312 VLTAFDSHAPL---TVVSSSGQI--RVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGN 366
V FD + T V++ G + R+H V + DG + W GGN
Sbjct: 3060 VALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLS-NPDGLAVDW---VGGN 3115
Query: 367 WGCYTEQQRCDGYWHCPNGRD 387
YW C GRD
Sbjct: 3116 L-----------YW-CDKGRD 3124
Score = 51.6 bits (122), Expect = 3e-06
Identities = 27/87 (31%), Positives = 36/87 (41%), Gaps = 9/87 (10%)
Query: 386 RDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF---------CQPGN 436
+ + C+ CS + P S +C +D C CQPG
Sbjct: 799 QQQVGTNKCRVNNGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPGE 858
Query: 437 FHCKNNRCVFESWVCDSQDDCGDGSDE 463
F C N+RC+ E W CD +DC D SDE
Sbjct: 859 FACANSRCIQERWKCDGDNDCLDNSDE 885
Score = 44.7 bits (104), Expect = 4e-04
Identities = 25/88 (28%), Positives = 40/88 (45%), Gaps = 9/88 (10%)
Query: 151 QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKV 210
+F C N +C+ + +CN D+CGD SDEE C+ + + A ++ +C+ R K
Sbjct: 3746 EFLCRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCV-RTEKA 3804
Query: 211 YTC--------LPESLKCDGNIDCLDLG 230
C +P C +CL G
Sbjct: 3805 AYCACRSGFHTVPGQPGCQDINECLRFG 3832
>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
sapiens]
Length = 3538
Score = 117 bits (294), Expect = 3e-26
Identities = 103/342 (30%), Positives = 159/342 (46%), Gaps = 45/342 (13%)
Query: 27 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 86
ACG T +R SGII+SP +P+EY +C+W I A PG+ I++ F DF ++
Sbjct: 240 ACGGT---MRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE----KY 292
Query: 87 DWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPN 146
D+L IE + + + G IPPP IS+++ + + F +D N +GF Y K+ +
Sbjct: 293 DYLEIEGSEPPTIWLS-GMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKKAID-- 349
Query: 147 CACDQFRCGNGKCIP---EAWKCNNMDECGDSSDEEICAKEANPPT----AAAFQPCAYN 199
F+ K P + K + ++E G + +C P + F +
Sbjct: 350 -----FKSRGFKLFPGKDNSNKFSILNEGGIKTASNLCPDPGEPENGKRIGSDFSLGSTV 404
Query: 200 QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID--------CDVPTCGQWLKYFYGTF 251
QF C + L+ +I C + + C V TCG L+ GTF
Sbjct: 405 QFSCDEDYV---------LQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTF 455
Query: 252 NSPNYPDFYPPGSNCTWLIDTGDHRKVI-LRFTDFKLDGTGYGDYVKIYDGLE-ENPHKL 309
SPN+P Y + C W+I + KVI + F +F L+ GY D + I DG E +P +
Sbjct: 456 TSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE-IGY-DTLTIGDGGEVGDPRTV 513
Query: 310 LRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 351
L+VLT S P +VS S Q+ +H D+ + GF Y+
Sbjct: 514 LQVLTG--SFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYK 553
Score = 93.6 bits (231), Expect = 7e-19
Identities = 86/340 (25%), Positives = 140/340 (41%), Gaps = 64/340 (18%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRA-NPGEIITISFQDFDIQGSRR 83
V CG ++ PSG TSP +P +Y + C W I A N ++I I+F++FD++
Sbjct: 441 VKTCGSN---LQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE---- 493
Query: 84 CNLDWLTIETYKNIESYRAC-----GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYF 138
D LTI + R GS +P +S +W+ +D+++ GF++ Y
Sbjct: 494 IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYK 553
Query: 139 SGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 198
+ E CGD +E + F
Sbjct: 554 EIEKES---------------------------CGDPGTPLYGIREGD-----GFSNRDV 581
Query: 199 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC-GQWLKYF---YGTFNSP 254
+F+C F + +S+ C N ++ ++P C L F GT SP
Sbjct: 582 LRFECQFGFELIGE---KSIVCQEN-------NQWSANIPICIFPCLSNFTAPMGTVLSP 631
Query: 255 NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 314
+YP+ Y NC W I + ++ L F DF L+ D++ + DG ++P + + T
Sbjct: 632 DYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE--SQFDFLAVKDG--DSPESPI-LGT 686
Query: 315 AFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 354
+ P + S+S +R+ F AD + RGFN TY G
Sbjct: 687 FTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFG 726
Score = 92.8 bits (229), Expect = 1e-18
Identities = 85/335 (25%), Positives = 142/335 (42%), Gaps = 59/335 (17%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 84
+Y CG T ++ +G I SPG+P YP NC+W I A I I FQ F ++
Sbjct: 62 IYTCGGT---LKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE---- 114
Query: 85 NLDWLTI-ETYKNIESYRA--CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 141
D+L++ + + + ++R G +PPP S++ +R SD +S GF++ Y +
Sbjct: 115 EYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQ 174
Query: 142 SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 201
S CGN P+ + GD ++
Sbjct: 175 SSS---------CGNPGVPPKGVLYGTRFDVGDKI-----------------------RY 202
Query: 202 QCLSRFT----KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYP 257
C++ + TC+ S+ N D I CG ++ G +SP++P
Sbjct: 203 SCVTGYILDGHPQLTCIANSV----NTASWDFPVPICRAEDACGGTMRGSSGIISSPSFP 258
Query: 258 DFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD 317
+ Y ++CTW I + L FTDF+++ DY++I +G E +
Sbjct: 259 NEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK--YDYLEI-EGSEP------PTIWLSG 309
Query: 318 SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQV 352
+ P ++S+ +R+HF D + RGF+A YQV
Sbjct: 310 MNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQV 344
Score = 80.9 bits (198), Expect = 5e-15
Identities = 81/322 (25%), Positives = 135/322 (41%), Gaps = 54/322 (16%)
Query: 37 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 96
AP G + SP +P Y +NC W I ++PG I +SF DFD++ D+L ++ +
Sbjct: 623 APMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKDGDS 678
Query: 97 IES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 153
ES G+ +P S+ + + F +D ++S +GF + Y +
Sbjct: 679 PESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT-------------- 724
Query: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 213
G+ +C P+ N GD+ FQ + C F K T
Sbjct: 725 FGHNEC-PDPGIPINARRFGDN-----------------FQLGSSISVICEEGFIK--TQ 764
Query: 214 LPESLKC---DGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLI 270
E++ C DG + L + C P CG G SP +P +Y NC W+I
Sbjct: 765 GTETITCILMDGKVMWSGLIPK--CGAP-CGGHFSAPSGVILSPGWPGYYKDSLNCEWVI 821
Query: 271 DTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD-SHAPLTVVSSSG 329
+ + + F F+ + Y D ++++DG P+ L +L +++ + P + SSS
Sbjct: 822 EAEPGHSIKITFERFQTE-LNY-DVLEVHDG----PNLLSPLLGSYNGTQVPQFLFSSSN 875
Query: 330 QIRVHFCADKVNAARGFNATYQ 351
I + F D + GF Y+
Sbjct: 876 FIYLLFTTDNSRSNNGFKIHYE 897
Score = 80.5 bits (197), Expect = 6e-15
Identities = 82/325 (25%), Positives = 128/325 (39%), Gaps = 65/325 (20%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 98
SG I SPG+P Y + C W I +PG I+++ F FD + S W ++
Sbjct: 1319 SGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW-DGPPENDML 1377
Query: 99 SYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKS---EEPNCACDQFRCG 155
GS IP S+ + + I+F +D IS+ GF + + S + +P + R G
Sbjct: 1378 LKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNG 1437
Query: 156 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 215
+G+ E GD T V+ C P
Sbjct: 1438 DGR------------EPGD---------------------------------TVVFQCDP 1452
Query: 216 -ESLKCDGNIDCLDLGDEI-------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCT 267
L+ + I C+ + + C P CG L G SPN+P YP +C
Sbjct: 1453 GYELQGEERITCIQVENRYFWQPSPPVCIAP-CGGNLTGSSGFILSPNFPHPYPHSRDCD 1511
Query: 268 WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVS 326
W I + L F F ++ D++ IYDG + N ++ +F DS P + S
Sbjct: 1512 WTITVNADYVISLAFISFSIEPN--YDFLYIYDGPDSNS----PLIGSFQDSKLPERIES 1565
Query: 327 SSGQIRVHFCADKVNAARGFNATYQ 351
SS + + F +D + GF+ Y+
Sbjct: 1566 SSNTMHLAFRSDGSVSYTGFHLEYK 1590
Score = 72.8 bits (177), Expect = 1e-12
Identities = 82/327 (25%), Positives = 121/327 (37%), Gaps = 62/327 (18%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 94
+R PSG I SPG+P YP +NC+W + G+ + +F F ++ D+L I
Sbjct: 967 VRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHH----DYLLITEN 1022
Query: 95 KNIES--YRACGSTIPPPY---ISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 149
+ R GS +PP + +RF SD +IS +GF + +
Sbjct: 1023 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE---------- 1072
Query: 150 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 209
N++ C D + ++ F F C S +
Sbjct: 1073 -----------------YNLEPCEDPGIPQYGSR-----IGFNFGIGDTLTFSCSSGY-- 1108
Query: 210 VYTCLPESLKCDGNIDCLDLGDEI------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 263
L+ I CL G + C V CG G SPNYP Y
Sbjct: 1109 -------RLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPNYPLNYENN 1160
Query: 264 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 323
C + I + + + F L GD +KIYDG ++ H LL T S LT
Sbjct: 1161 HECIYSIQVQAGKGINISARTFHL---AQGDVLKIYDGKDKTTH-LLGAFTG-ASMRGLT 1215
Query: 324 VVSSSGQIRVHFCADKVNAARGFNATY 350
+ S+S Q+ + F +D GF Y
Sbjct: 1216 LSSTSNQLWLEFNSDTEGTDEGFQLVY 1242
Score = 72.0 bits (175), Expect = 2e-12
Identities = 62/256 (24%), Positives = 99/256 (38%), Gaps = 69/256 (26%)
Query: 37 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 96
APSG+I SPGWP Y +NC W I A PG I I+F+ F + N D L + N
Sbjct: 797 APSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPN 852
Query: 97 -----IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNC---- 147
+ SY G+ +P SS + I++ F +D++ S GF++ Y S +C
Sbjct: 853 LLSPLLGSYN--GTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPG 910
Query: 148 ---------------ACDQFRCGNG---------KCIPEAWKCNNMDECGDSSDEEICAK 183
+ F C +G C W + + C + +C
Sbjct: 911 IPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-----DALCGG 965
Query: 184 EANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQW 243
+ P+ P Y +F P SL C +D T G+
Sbjct: 966 DVRGPSGTILSP-GYPEF------------YPNSLNCTWTVDV------------THGKG 1000
Query: 244 LKYFYGTFNSPNYPDF 259
+++ + TF+ ++ D+
Sbjct: 1001 VQFNFHTFHLEDHHDY 1016
Score = 71.2 bits (173), Expect = 4e-12
Identities = 68/304 (22%), Positives = 121/304 (39%), Gaps = 50/304 (16%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 98
SG+I SPG+P YP+ ++C+W I G + + F +F + D+L + + +
Sbjct: 2015 SGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH----DYLEVRSGSSET 2070
Query: 99 SY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 155
S R G IP S+ + FHSD + +++GF + Y + + + C
Sbjct: 2071 STVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS---------CP 2121
Query: 156 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 215
+ + + N G + F+C +T +
Sbjct: 2122 DPRPFRNGFVIGNDFTVGQTI-----------------------SFECFPGYTLIGN--- 2155
Query: 216 ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDH 275
+L C + + + CG + GT SP YPD YP +C WL+
Sbjct: 2156 SALTCLHGVS-RNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPG 2214
Query: 276 RKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL-TVVSSSGQIRVH 334
+ + FT L D++ ++DG ++N + + F + L +V S+S QI +
Sbjct: 2215 NGIYINFT--VLQTEPIYDFITVWDGPDQNSPQ----IGQFSGNTALESVYSTSNQILIK 2268
Query: 335 FCAD 338
F +D
Sbjct: 2269 FHSD 2272
Score = 70.1 bits (170), Expect = 8e-12
Identities = 85/318 (26%), Positives = 123/318 (38%), Gaps = 50/318 (15%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN-- 96
SG I SP +P YP +C W I N +I+++F F I+ N D+L I +
Sbjct: 1492 SGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEP----NYDFLYIYDGPDSN 1547
Query: 97 ---IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 153
I S++ S +P SS + + + F SD ++S GF L Y K++ D
Sbjct: 1548 SPLIGSFQ--DSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY---KAKLRESCFDPGN 1602
Query: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 213
NG + +K + T + Y + + TC
Sbjct: 1603 IMNGTRLGMDYKLGS--------------------TVTYYCDAGY-----VLQGYSTLTC 1637
Query: 214 LPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTG 273
+ G L C P CG GT SPNYP Y G NC + I
Sbjct: 1638 IMGDDGRPGWNRALP-----SCHAP-CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVP 1691
Query: 274 DHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRV 333
V +F F+ T D V++YDG + LL L+ S L +SS QI +
Sbjct: 1692 KEFVVFGQFVFFQ---TSLHDVVEVYDGPTQQ-SSLLSSLSGSHSGESLP-LSSGNQITI 1746
Query: 334 HFCADKVNAARGFNATYQ 351
F + A+GF+ YQ
Sbjct: 1747 RFTSVGPITAKGFHFVYQ 1764
Score = 67.8 bits (164), Expect = 4e-11
Identities = 74/323 (22%), Positives = 125/323 (38%), Gaps = 64/323 (19%)
Query: 40 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY----- 94
G I SPG+P Y +NC W I G I + F + +W +++ Y
Sbjct: 1844 GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH------NWDSLDFYDGGDN 1897
Query: 95 --KNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQF 152
+ SY G+TIP S+ +++++ F SD ++S GF L Y +
Sbjct: 1898 NAPRLGSY--SGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTA------------- 1942
Query: 153 RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT---- 208
G C PE ++ + GD + FQC ++
Sbjct: 1943 -IGLDSC-PEPQTPSSGIKIGD-----------------RYMVGDVVSFQCDQGYSLQGH 1983
Query: 209 KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTW 268
TC+P ++ I + CG + F G SP +P YP +CTW
Sbjct: 1984 SHITCMPGPVR--------RWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTW 2035
Query: 269 LIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSS 328
I+ V L+F +F + DY+++ G E + R+ P ++ S++
Sbjct: 2036 TINLPIGFGVHLQFVNFSTE--TIHDYLEVRSGSSETSTVIGRL---SGPQIPSSLFSTT 2090
Query: 329 GQIRVHFCADKVNAARGFNATYQ 351
+ ++F +D +GF+ YQ
Sbjct: 2091 HETSLYFHSDYSQNKQGFHIVYQ 2113
Score = 65.9 bits (159), Expect = 2e-10
Identities = 85/342 (24%), Positives = 132/342 (38%), Gaps = 61/342 (17%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 91
I A +G I SPG+P EYP +C W +R PG I I+F + D++T+
Sbjct: 2183 ITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----YDFITVWDG 2238
Query: 92 ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 151
+ + + G+T S+ + I I+FHSD S F L+Y + +
Sbjct: 2239 PDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQLRV------- 2290
Query: 152 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT--- 208
C +P A DE F+ ++QCL FT
Sbjct: 2291 --CQPPPPVPNAEILTEDDE---------------------FEIGDIIRYQCLPGFTLVG 2327
Query: 209 -KVYTC-LPESLKCDGN---IDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 263
+ TC L E L+ DG L +E+ D G SP YPD YP
Sbjct: 2328 NAILTCRLGERLQMDGAPPVCQVLCPANELRLDST----------GVILSPGYPDSYPNL 2377
Query: 264 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 323
C W I + + F +F + D +++YDG N + + + D +
Sbjct: 2378 QMCAWSISVEKGYNITM-FVEFFQTEKEF-DVLQVYDG--PNIQSPVLISLSGDYSSAFN 2433
Query: 324 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 365
+ S+ ++ + + AD N +GF Y + +C E P G
Sbjct: 2434 ITSNGHEVFLQWSADHGNNKKGFRIRY-IAFYCSTPESPPHG 2474
Score = 48.1 bits (113), Expect = 3e-05
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 10/119 (8%)
Query: 235 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 294
CD CG ++ GT SP YP+FYP NCTW +D + V F F L+ + D
Sbjct: 959 CDA-LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLE--DHHD 1015
Query: 295 YVKIYDGLEENPHKLLRVLTAFDSHAPLTV---VSSSGQIRVHFCADKVNAARGFNATY 350
Y+ I EN + S P T+ + + + ++ F +D + GFN T+
Sbjct: 1016 YLLI----TENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1070
Score = 46.2 bits (108), Expect = 1e-04
Identities = 74/320 (23%), Positives = 124/320 (38%), Gaps = 66/320 (20%)
Query: 40 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI-QGSRRCNLDWLTIETYKNIE 98
GI+ SP +P Y C + I+ G+ I IS + F + QG D L I K+
Sbjct: 1146 GILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG------DVLKIYDGKDKT 1199
Query: 99 SY---RACGSTIPPPYISS-QDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRC 154
++ G+++ +SS + +W+ F+SD + +GF+L Y S +
Sbjct: 1200 THLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFE------------- 1246
Query: 155 GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCL 214
+ C D + K ++ A T +Y C
Sbjct: 1247 --------------LSHCEDPGIPQFGYKISDQGHFAG--------------STIIYGCN 1278
Query: 215 P-ESLKCDGNIDCLDLGDE--IDCDVPTC-----GQWLKYFYGTFNSPNYPDFYPPGSNC 266
P +L + C+ G+ D +P+C G++ G SP YP Y C
Sbjct: 1279 PGYTLHGSSLLKCM-TGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRC 1337
Query: 267 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 326
W+I+ V L+F F D D ++++DG EN LL+ ++ S P + S
Sbjct: 1338 MWMIEVDPGNIVSLQFLAF--DTEASHDILRVWDGPPEN-DMLLKEISG--SLIPEGIHS 1392
Query: 327 SSGQIRVHFCADKVNAARGF 346
+ + + F D + GF
Sbjct: 1393 TLNIVTIQFDTDFYISKSGF 1412
Score = 43.5 bits (101), Expect = 8e-04
Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 8/133 (6%)
Query: 235 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 294
C VP CG L GT SP YP+ Y NC W I + + ++ F + D
Sbjct: 1831 CIVP-CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN--WD 1887
Query: 295 YVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 354
+ YDG + N R+ + + P + S+S + ++F +D +A GF+ Y G
Sbjct: 1888 SLDFYDGGDNNAP---RLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 1944
Query: 355 F--CLPWEIPCGG 365
C + P G
Sbjct: 1945 LDSCPEPQTPSSG 1957
>gi|6912724 tolloid-like 2 [Homo sapiens]
Length = 1015
Score = 117 bits (293), Expect = 4e-26
Identities = 118/440 (26%), Positives = 178/440 (40%), Gaps = 88/440 (20%)
Query: 27 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 86
ACGET ++ +G ++PG+P+ YP+ +C W I PGE I ++F D+ SR C
Sbjct: 350 ACGET---LQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWY 406
Query: 87 DWLTIET---YKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY------ 137
D++ + K R CG IP P +S+ +W+ F S NI KGF AY
Sbjct: 407 DYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYEATCGG 466
Query: 138 ----FSGKSEEPNCACDQFRCGNGKCI--------------PEAWKCNNMDECG------ 173
+G+ + PN D +R + +C+ +A++ D C
Sbjct: 467 DMNKDAGQIQSPNYP-DDYR-PSKECVWRITVSEGFHVGLTFQAFEIERHDSCAYDYLEV 524
Query: 174 -DSSDEE------ICAKEANPPTAAAFQPCAYNQFQ----------CLSRFTKVYTC-LP 215
D EE C E P + + +F + F +V C P
Sbjct: 525 RDGPTEESALIGHFCGYE-KPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDECSWP 583
Query: 216 ESLKCD-------GNIDC-LDLGDEIDCDVP----TCGQWLKYFYGTFNSPNYPDFYPPG 263
+ C+ G+ C D G E+ D CG ++ GT SP +P YP
Sbjct: 584 DHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEYPTN 643
Query: 264 SNCTWLIDTGDHRKVILRFTDFKLDGTGY--GDYVKIYDGLEENPHKLLRVLTAFDSHAP 321
NC W + ++ L+F F+L+G D+V++ GL + R S P
Sbjct: 644 KNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPDAKLHGRFC---GSETP 700
Query: 322 LTVVSSSGQIRVHFCADKVNAARGFNATYQVD--------GFCLPWEIPCGGNWGCYTEQ 373
+ S S +RV F +D + RGF A + D G C + C +G Y +
Sbjct: 701 EVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDECAKDNGGC---QHECVNTFGSYLCR 757
Query: 374 QRCDGYWHCPNGRD--ETNC 391
R +GYW NG D E C
Sbjct: 758 CR-NGYWLHENGHDCKEAGC 776
Score = 116 bits (291), Expect = 8e-26
Identities = 92/334 (27%), Positives = 142/334 (42%), Gaps = 77/334 (23%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 98
+G ITSPGWP EYP NC W + A I++ F+ F+++G+ C D++ + + + +
Sbjct: 628 NGTITSPGWPKEYPTNKNCVWQVVAPAQYRISLQFEVFELEGNDVCKYDFVEVRSGLSPD 687
Query: 99 SY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 155
+ R CGS P S +++ + F SD+ +S++GFR +FS K E CA D
Sbjct: 688 AKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDE---CAKD----- 739
Query: 156 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 215
NG C Q +C++ F Y C
Sbjct: 740 NGGC----------------------------------------QHECVNTFGS-YLC-- 756
Query: 216 ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDH 275
+C + G DC C + GT SPN+PD YP CTW I +
Sbjct: 757 ---RCRNGYWLHENGH--DCKEAGCAHKISSVEGTLASPNWPDKYPSRRECTWNISSTAG 811
Query: 276 RKVILRFTDFKLD---GTGYGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVSSSGQI 331
+V L F +F+++ Y D++++YDG P L +L F S P V+S +
Sbjct: 812 HRVKLTFNEFEIEQHQECAY-DHLEMYDG----PDSLAPILGRFCGSKKPDPTVASGSSM 866
Query: 332 RVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 365
+ F +D +GF A + + CGG
Sbjct: 867 FLRFYSDASVQRKGFQAVHSTE---------CGG 891
Score = 76.6 bits (187), Expect = 9e-14
Identities = 36/109 (33%), Positives = 62/109 (56%), Gaps = 7/109 (6%)
Query: 34 QIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIET 93
+I + G + SP WP +YP++ C+W I + G + ++F +F+I+ + C D L E
Sbjct: 779 KISSVEGTLASPNWPDKYPSRRECTWNISSTAGHRVKLTFNEFEIEQHQECAYDHL--EM 836
Query: 94 YKNIESY-----RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 137
Y +S R CGS P P ++S +++RF+SD ++ RKGF+ +
Sbjct: 837 YDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVH 885
Score = 60.1 bits (144), Expect = 8e-09
Identities = 32/101 (31%), Positives = 52/101 (51%), Gaps = 7/101 (6%)
Query: 49 SEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESY-----RAC 103
+ YP++ C W I A G + ++F+ F+++ C D++ E Y +S R C
Sbjct: 911 NNYPSEARCDWVIVAEDGYGVELTFRTFEVEEEADCGYDYM--EAYDGYDSSAPRLGRFC 968
Query: 104 GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEE 144
GS S+ D + IRF +DD I++KGF Y S K ++
Sbjct: 969 GSGPLEEIYSAGDSLMIRFRTDDTINKKGFHARYTSTKFQD 1009
Score = 58.2 bits (139), Expect = 3e-08
Identities = 39/131 (29%), Positives = 58/131 (44%), Gaps = 14/131 (10%)
Query: 238 PTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL--DGTGYGDY 295
P CG+ L+ G F++P +P+ YP S+C W I K++L FT L + DY
Sbjct: 349 PACGETLQDTTGNFSAPGFPNGYPSYSHCVWRISVTPGEKIVLNFTSMDLFKSRLCWYDY 408
Query: 296 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGF 355
V++ DG L R P +VS+ ++ V F + +GF A Y
Sbjct: 409 VEVRDGYWRKAPLLGRFC---GDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAY----- 460
Query: 356 CLPWEIPCGGN 366
E CGG+
Sbjct: 461 ----EATCGGD 467
>gi|13899255 membrane frizzled-related protein [Homo sapiens]
Length = 579
Score = 116 bits (290), Expect = 1e-25
Identities = 95/366 (25%), Positives = 141/366 (38%), Gaps = 66/366 (18%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 94
+ P G +SP +P YP +C W I+ I + + I+ C D L +
Sbjct: 148 LSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVASCLFDRLELSPE 207
Query: 95 KNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRC 154
R CG PP ++ H+ + F SD ++ GF Y
Sbjct: 208 PEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWY------------QAMAP 255
Query: 155 GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCL 214
G G C + ++C D+ IC L
Sbjct: 256 GRGSCAHDEFRC----------DQLICL-------------------------------L 274
Query: 215 PESLKCDGNIDCLDLGDEIDCDVPT--CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDT 272
P+S+ CDG +C D DE +C CG L GTF++P+Y YP CTW I
Sbjct: 275 PDSV-CDGFANCADGSDETNCSAKFSGCGGNLTGLQGTFSTPSYLQQYPHQLLCTWHISV 333
Query: 273 GDHRKVILRFTDFKLDGTG--YGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQ 330
+ L+F +F L+ DYV++Y+ LL + P +VSS +
Sbjct: 334 PAGHSIELQFHNFSLEAQDECKFDYVEVYETSSSGAFSLLGRFCG--AEPPPHLVSSHHE 391
Query: 331 IRVHFCADKVNAARGFNATY----QVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGR 386
+ V F D ++ GF+ATY + C P E+ C GC Q CD + C +G
Sbjct: 392 LAVLFRTDHGISSGGFSATYLAFNATENPCGPSELSCQAG-GCKGVQWMCDMWRDCTDGS 450
Query: 387 DETNCT 392
D+ NC+
Sbjct: 451 DD-NCS 455
Score = 87.0 bits (214), Expect = 6e-17
Identities = 46/162 (28%), Positives = 73/162 (45%), Gaps = 9/162 (5%)
Query: 40 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIES 99
G ++P + +YP ++ C+W I G I + F +F ++ C D+ +E Y+ S
Sbjct: 310 GTFSTPSYLQQYPHQLLCTWHISVPAGHSIELQFHNFSLEAQDECKFDY--VEVYETSSS 367
Query: 100 Y------RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 153
R CG+ PP +SS + + F +D IS GF Y + + E C +
Sbjct: 368 GAFSLLGRFCGAEPPPHLVSSHHELAVLFRTDHGISSGGFSATYLAFNATENPCGPSELS 427
Query: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 195
C G C W C+ +C D SD+ C+ PP A +P
Sbjct: 428 CQAGGCKGVQWMCDMWRDCTDGSDDN-CSGPLFPPPELACEP 468
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/158 (31%), Positives = 71/158 (44%), Gaps = 9/158 (5%)
Query: 239 TCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKI 298
TCG L G F+SPNYPD YPP ++C W I + L+ ++ +
Sbjct: 143 TCGGLLSGPRGFFSSPNYPDPYPPNTHCVWHIQVATDHAIQLKIEALSIESVA----SCL 198
Query: 299 YDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQV----DG 354
+D LE +P +L P T+ +++ + V F +D GF+A YQ G
Sbjct: 199 FDRLELSPEPEGPLLRVCGRVPPPTLNTNASHLLVVFVSDSSVEGFGFHAWYQAMAPGRG 258
Query: 355 FCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT 392
C E C C CDG+ +C +G DETNC+
Sbjct: 259 SCAHDEFRC-DQLICLLPDSVCDGFANCADGSDETNCS 295
Score = 38.1 bits (87), Expect = 0.034
Identities = 20/58 (34%), Positives = 26/58 (44%), Gaps = 3/58 (5%)
Query: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC--PVIVPTRVITAAVIGSLICGL 487
C P C+ C W+CD DC DGSD +NC P+ P + V + GL
Sbjct: 421 CGPSELSCQAGGCKGVQWMCDMWRDCTDGSD-DNCSGPLFPPPELACEPVQVEMCLGL 477
Score = 37.0 bits (84), Expect = 0.076
Identities = 15/35 (42%), Positives = 17/35 (48%)
Query: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
C F C C+ VCD +C DGSDE NC
Sbjct: 260 CAHDEFRCDQLICLLPDSVCDGFANCADGSDETNC 294
>gi|22547221 tolloid-like 1 [Homo sapiens]
Length = 1013
Score = 115 bits (287), Expect = 2e-25
Identities = 96/365 (26%), Positives = 156/365 (42%), Gaps = 80/365 (21%)
Query: 27 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 86
ACG ++ +G IT+PGWP EYP NC W + A I++ F+ F+++G+ C
Sbjct: 617 ACGGLLTKL---NGTITTPGWPKEYPPNKNCVWQVVAPTQYRISVKFEFFELEGNEVCKY 673
Query: 87 DWLTIETYKNIESY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSE 143
D++ I + + ES + CG+ +P S +++ I F SD+ +S+KGF+ +FS K E
Sbjct: 674 DYVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDE 733
Query: 144 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQC 203
C+ D NG C EC ++ +C QC
Sbjct: 734 ---CSKD-----NGGC---------QHECVNTMGSYMC--------------------QC 756
Query: 204 LSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 263
+ F ++ DC C Q + G SPN+PD YP
Sbjct: 757 RNGFVL-------------------HDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSR 797
Query: 264 SNCTWLIDTGDHRKVILRFTDFKLD---GTGYGDYVKIYDGLEENPHKLLRVLTAFDSHA 320
CTW I ++ L F++F+++ Y D+++++DG E L R+ +
Sbjct: 798 KECTWEISATPGHRIKLAFSEFEIEQHQECAY-DHLEVFDGETEKSPILGRLC---GNKI 853
Query: 321 PLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYW 380
P +V++ ++ V F +D +GF AT+ + CGG E + D Y
Sbjct: 854 PDPLVATGNKMFVRFVSDASVQRKGFQATHSTE---------CGGR--LKAESKPRDLYS 902
Query: 381 HCPNG 385
H G
Sbjct: 903 HAQFG 907
Score = 99.8 bits (247), Expect = 1e-20
Identities = 114/484 (23%), Positives = 183/484 (37%), Gaps = 95/484 (19%)
Query: 27 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 86
ACGET ++ +G ++SPG+P+ YP+ +C W + PGE I ++F D+ S C
Sbjct: 348 ACGET---LQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWY 404
Query: 87 DWLTIET---YKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS---- 139
D++ + K+ R CG +P S+ +WI F S N KGF Y +
Sbjct: 405 DYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAICGG 464
Query: 140 ------GKSEEPNCACDQFR----CGNGKCIPEAW---------KCNNMDECGDSSDEEI 180
G+ + PN D +R C + E++ + D C E
Sbjct: 465 EIRKNEGQIQSPNYP-DDYRPMKECVWKITVSESYHVGLTFQSFEIERHDNCAYDYLEVR 523
Query: 181 CAKEANPPTAAAFQPCAYNQFQ------------------------CLSRFTKVYTCL-P 215
N P F C Y++ + + F + C P
Sbjct: 524 DGTSENSPLIGRF--CGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANFFKEEDECAKP 581
Query: 216 ESLKCD-------GNIDC-LDLGDEIDCDVPTC----GQWLKYFYGTFNSPNYPDFYPPG 263
+ C+ G+ C + G E+ D +C G L GT +P +P YPP
Sbjct: 582 DRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPKEYPPN 641
Query: 264 SNCTWLIDTGDHRKVILRFTDFKLDGTGY--GDYVKIYDGLEENPHKLLRVLTAFDSHAP 321
NC W + ++ ++F F+L+G DYV+I+ GL + A P
Sbjct: 642 KNCVWQVVAPTQYRISVKFEFFELEGNEVCKYDYVEIWSGLSSESKLHGKFCGA---EVP 698
Query: 322 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCG-GNWGCYTEQQRCDGYW 380
+ S +R+ F +D + +GF A + D + C N GC E G +
Sbjct: 699 EVITSQFNNMRIEFKSDNTVSKKGFKAHFFSD------KDECSKDNGGCQHECVNTMGSY 752
Query: 381 --HCPNG----RDETNCTMCQKEEFPCSRNGVC--------YPRSDRCNYQNHCPNGSDE 426
C NG ++ +C + E+ S +G+ YP C ++ G
Sbjct: 753 MCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKYPSRKECTWEISATPGHRI 812
Query: 427 KNCF 430
K F
Sbjct: 813 KLAF 816
Score = 65.5 bits (158), Expect = 2e-10
Identities = 31/96 (32%), Positives = 52/96 (54%), Gaps = 7/96 (7%)
Query: 49 SEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESY-----RAC 103
+ YP +++C W + + G + +SFQ F+++ C D+ +E + ++S R C
Sbjct: 909 NNYPGQVDCEWLLVSERGSRLELSFQTFEVEEEADCGYDY--VELFDGLDSTAVGLGRFC 966
Query: 104 GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS 139
GS P S D + I FH+DD I++KGF + Y S
Sbjct: 967 GSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYKS 1002
Score = 55.1 bits (131), Expect = 3e-07
Identities = 45/161 (27%), Positives = 69/161 (42%), Gaps = 36/161 (22%)
Query: 238 PTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFT--DFKLDGTGYGDY 295
P CG+ L+ G +SP +P+ YP ++C W + K++L FT D + DY
Sbjct: 347 PACGETLQESNGNLSSPGFPNGYPSYTHCIWRVSVTPGEKIVLNFTTMDLYKSSLCWYDY 406
Query: 296 VKIYDGL-EENP-------HKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFN 347
+++ DG ++P KL VLT+ DS + SSS + +GF
Sbjct: 407 IEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWV-----------GKGFA 455
Query: 348 ATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDE 388
A Y E CGG E ++ +G PN D+
Sbjct: 456 AVY---------EAICGG------EIRKNEGQIQSPNYPDD 481
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 112 bits (279), Expect = 2e-24
Identities = 101/351 (28%), Positives = 138/351 (39%), Gaps = 99/351 (28%)
Query: 145 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
P C+ F C NGKCI +W C+ ++C D SDE+ C PP + C ++F C
Sbjct: 69 PTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDEQDC-----PP-----RECEEDEFPCQ 118
Query: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 264
+ + C+ CDG+ DC D DE CD+ C +F
Sbjct: 119 NGY-----CIRSLWHCDGDNDCGDNSDE-QCDMRKCSD--------------KEFRCSDG 158
Query: 265 NCT---WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAP 321
+C W D GD TD K DG +E + P
Sbjct: 159 SCIAEHWYCD-GD--------TDCK-------------DGSDE-------------ENCP 183
Query: 322 LTVVSSSGQIRVHFCADKVNAARGFNATYQVDG--FCLPW--EIPCGGNWGCYTEQ---- 373
V + + CA R Y DG C W E C + C + +
Sbjct: 184 SAVPAPPCNLEEFQCA----YGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSGEFMCD 239
Query: 374 --------QRCDGYWHCPNGRDETNCT--MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 423
RCDG C + DE NCT MC E+F C +G C S RC+ ++ C +
Sbjct: 240 SGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRC-HSGRCVRLSWRCDGEDDCADN 298
Query: 424 SDEKNCF-----FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE---ENC 466
SDE+NC C F C N RC+ + +C+ +DCGD SDE +NC
Sbjct: 299 SDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNC 349
Score = 92.4 bits (228), Expect = 2e-18
Identities = 47/119 (39%), Positives = 60/119 (50%), Gaps = 5/119 (4%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 413
C P + C N C CDG C + DE +C C+++EFPC +NG C
Sbjct: 71 CSPLDFHCD-NGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPC-QNGYCIRSLWH 128
Query: 414 CNYQNHCPNGSDEK-NCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVIVP 471
C+ N C + SDE+ + C F C + C+ E W CD DC DGSDEENCP VP
Sbjct: 129 CDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVP 187
Score = 80.9 bits (198), Expect = 5e-15
Identities = 52/150 (34%), Positives = 64/150 (42%), Gaps = 17/150 (11%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 413
C E PC + C CDG C + DE C M C +EF CS +G C
Sbjct: 110 CEEDEFPCQNGY-CIRSLWHCDGDNDCGDNSDE-QCDMRKCSDKEFRCS-DGSCIAEHWY 166
Query: 414 CNYQNHCPNGSDEKNCFFCQPG------NFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 467
C+ C +GSDE+NC P F C RC+ + + CD DDCGD SDE +C
Sbjct: 167 CDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCAYGRCILDIYHCDGDDDCGDWSDESDCS 226
Query: 468 VIVPTRVITAAVIGSLICGLLLVIALGCTC 497
P R G +C L I G C
Sbjct: 227 SHQPCR------SGEFMCDSGLCINAGWRC 250
Score = 77.8 bits (190), Expect = 4e-14
Identities = 34/92 (36%), Positives = 49/92 (53%), Gaps = 6/92 (6%)
Query: 382 CPNGRDETNCTMCQKEEFPCSRNGV----CYPRSDRCNYQNHCPNGSDEKNCFF--CQPG 435
C +G + C + F C+ + + C P +C+ N C + SDE C C P
Sbjct: 15 CAHGLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPL 74
Query: 436 NFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 467
+FHC N +C+ SWVCD +DC D SDE++CP
Sbjct: 75 DFHCDNGKCIRRSWVCDGDNDCEDDSDEQDCP 106
Score = 73.9 bits (180), Expect = 6e-13
Identities = 72/298 (24%), Positives = 108/298 (36%), Gaps = 86/298 (28%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
C+ +FRC +G CI E W C+ +C D SDEE C P+A PC +FQC
Sbjct: 148 CSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENC------PSAVPAPPCNLEEFQC--- 198
Query: 207 FTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 266
C+ + CDG+ DC D DE DC + P +
Sbjct: 199 --AYGRCILDIYHCDGDDDCGDWSDESDC----------------------SSHQPCRSG 234
Query: 267 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 326
++ D+G + ++ DG D D T +
Sbjct: 235 EFMCDSG-----LCINAGWRCDGDADCD-------------------DQSDERNCTTSMC 270
Query: 327 SSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGR 386
++ Q R H + R +++ DG E C N ++++ C+
Sbjct: 271 TAEQFRCH-------SGRCVRLSWRCDG-----EDDCADN----SDEENCE--------- 305
Query: 387 DETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQP--GNFHCKNN 442
T C ++F C NG C + CN N C + SDE C+P G +C N
Sbjct: 306 -NTGSPQCALDQFLC-WNGRCIGQRKLCNGVNDCGDNSDESPQQNCRPRTGEENCNVN 361
Score = 60.5 bits (145), Expect = 6e-09
Identities = 38/108 (35%), Positives = 49/108 (45%), Gaps = 22/108 (20%)
Query: 140 GKSEEPNCACDQ--FRC-----GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAA 192
G + P CAC + F C G CIP W+C+ ++CGD SDE+ C PT
Sbjct: 18 GLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCIL----PT--- 70
Query: 193 FQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 240
C+ F C + C+ S CDG+ DC D DE DC C
Sbjct: 71 ---CSPLDFHCDNG-----KCIRRSWVCDGDNDCEDDSDEQDCPPREC 110
Score = 59.7 bits (143), Expect = 1e-08
Identities = 32/95 (33%), Positives = 43/95 (45%), Gaps = 16/95 (16%)
Query: 142 SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 201
S +P C +F C +G CI W+C+ +C D SDE C C QF
Sbjct: 227 SHQP-CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSM----------CTAEQF 275
Query: 202 QCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCD 236
+C S C+ S +CDG DC D DE +C+
Sbjct: 276 RCHSG-----RCVRLSWRCDGEDDCADNSDEENCE 305
>gi|157502199 CUB and Sushi multiple domains 1 [Homo sapiens]
Length = 3565
Score = 111 bits (278), Expect = 2e-24
Identities = 101/336 (30%), Positives = 149/336 (44%), Gaps = 32/336 (9%)
Query: 27 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 86
ACG T +R S I+SP +PSEY +C+W I A PG+ I + F DF ++
Sbjct: 207 ACGGT---LRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLEE----GY 259
Query: 87 DWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPN 146
D+L I + S G +P P ISS++ + + F SD N RKGF + K+ E
Sbjct: 260 DFLEI-SGTEAPSIWLTGMNLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQVKKAIE-- 316
Query: 147 CACDQFRCGNGKCIPE---AWKCNNMDECGDSSDEEICAKEANPP----TAAAFQPCAYN 199
+ K +P + K + + + G + ++C P + F N
Sbjct: 317 -----LKSRGVKMLPSKDGSHKNSVLSQGGVALVSDMCPDPGIPENGRRAGSDFSRVGAN 371
Query: 200 -QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTCGQWLKYFYGTFNSPNY 256
QF C + + +S+ C + L + C TCG L+ G SPNY
Sbjct: 372 VQFSCEDNYVLQGS---KSITCQRVTETLAAWSDHRPICRARTCGSNLRGPSGVITSPNY 428
Query: 257 PDFYPPGSNCTWLIDTGDHRKVI-LRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTA 315
P Y ++C W+I T D KVI L F +F+L+ GY G + +L VLT
Sbjct: 429 PVQYEDNAHCVWVITTTDPDKVIKLAFEEFELE-RGYDTLTVGDAGKVGDTRSVLYVLTG 487
Query: 316 FDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 351
S P +VS S Q+ +H +D + GF A YQ
Sbjct: 488 --SSVPDLIVSMSNQMWLHLQSDDSIGSPGFKAVYQ 521
Score = 87.0 bits (214), Expect = 6e-17
Identities = 90/337 (26%), Positives = 143/337 (42%), Gaps = 63/337 (18%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 84
+ ACG + P+G+I SP +P YP C W ++ NP +I + F+ F+++ S
Sbjct: 1449 IAACGGN---LTGPAGVILSPNYPQPYPPGKECDWRVKVNPDFVIALIFKSFNMEPS--- 1502
Query: 85 NLDWLTIETYKN-----IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS 139
D+L I ++ I SY+ GS P SS + +++ F SD ++ GF + +
Sbjct: 1503 -YDFLHIYEGEDSNSPLIGSYQ--GSQAPERIESSGNSLFLAFRSDASVGLSGFAIEF-- 1557
Query: 140 GKSEEPNCAC-DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 198
E+P AC D NG + +K +
Sbjct: 1558 --KEKPREACFDPGNIMNGTRVGTDFKLGST----------------------------- 1586
Query: 199 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEI--DCDVPTCGQWLKYFYGTFNSPNY 256
+QC S + K+ P S+ C D D++ C+ P CG G SPNY
Sbjct: 1587 ITYQCDSGY-KILD--PSSITCVIGADGKPSWDQVLPSCNAP-CGGQYTGSEGVVLSPNY 1642
Query: 257 PDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAF 316
P Y G C + I V +F F+ T D +++DG H R+L++
Sbjct: 1643 PHNYTAGQICLYSITVPKEFVVFGQFAYFQ---TALNDLAELFDG----THAQARLLSSL 1695
Query: 317 D-SHAPLTV-VSSSGQIRVHFCADKVNAARGFNATYQ 351
SH+ T+ +++S QI + F A +ARGF+ YQ
Sbjct: 1696 SGSHSGETLPLATSNQILLRFSAKSGASARGFHFVYQ 1732
Score = 82.4 bits (202), Expect = 2e-15
Identities = 89/354 (25%), Positives = 142/354 (40%), Gaps = 61/354 (17%)
Query: 12 RWRSALLLLFLAGVYA----------CGETPEQIRAPSGIITSPGWPSEYPAKINCSWFI 61
R++S LLLL L + A CG ++ P+G I SPG+P YP NC+W I
Sbjct: 6 RFQSLLLLLGLLVLCARLLTAAKGQNCGGL---VQGPNGTIESPGFPHGYPNYANCTWII 62
Query: 62 RANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYKNIESYRACGSTIPPPYISSQDHI 118
I +SF F ++ + D L++ + + R G +P +S+ +
Sbjct: 63 ITGERNRIQLSFHTFALEE----DFDILSVYDGQPQQGNLKVRLSGFQLPSSIVSTGSIL 118
Query: 119 WIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDE 178
+ F +D +S +GF+ Y S CGN I + GD
Sbjct: 119 TLWFTTDFAVSAQGFKALYEVLPSHT---------CGNPGEILKGVLHGTRFNIGDKI-- 167
Query: 179 EICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVP 238
++ CL + + + GN D
Sbjct: 168 ---------------------RYSCLPGYILEGHAILTCIVSPGNGASWDFPAPFCRAEG 206
Query: 239 TCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKI 298
CG L+ + +SP++P Y ++CTW I + L FTDF+L+ GY D+++I
Sbjct: 207 ACGGTLRGTSSSISSPHFPSEYENNADCTWTILAEPGDTIALVFTDFQLE-EGY-DFLEI 264
Query: 299 YDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQV 352
G E L + + P V+SS +R+HF +D + +GFNA +QV
Sbjct: 265 -SGTEAPSIWLTGM------NLPSPVISSKNWLRLHFTSDSNHRRKGFNAQFQV 311
Score = 82.0 bits (201), Expect = 2e-15
Identities = 80/319 (25%), Positives = 126/319 (39%), Gaps = 59/319 (18%)
Query: 37 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 96
A SG I SPG+P+ Y ++C+W I A+PG+ I++ F FD + + W +
Sbjct: 1285 ATSGRILSPGYPAPYDNNLHCTWIIEADPGKTISLHFIVFDTEMAHDILKVW-DGPVDSD 1343
Query: 97 IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY---FSGKSEEPNCACDQFR 153
I GS +P S+ + + ++F SD IS+ GF + + + +P + R
Sbjct: 1344 ILLKEWSGSALPEDIHSTFNSLTLQFDSDFFISKSGFSIQFSTSIAATCNDPGMPQNGTR 1403
Query: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 213
G+ + E GD+ FQC +
Sbjct: 1404 YGDSR------------EAGDTV-----------------------TFQCDPGY------ 1422
Query: 214 LPESLKCDGNIDCLDLGDEI--DCDVPT----CGQWLKYFYGTFNSPNYPDFYPPGSNCT 267
L+ I C+ L + D PT CG L G SPNYP YPPG C
Sbjct: 1423 ---QLQGQAKITCVQLNNRFFWQPDPPTCIAACGGNLTGPAGVILSPNYPQPYPPGKECD 1479
Query: 268 WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSS 327
W + + L F F ++ + D++ IY+G + N + + S AP + SS
Sbjct: 1480 WRVKVNPDFVIALIFKSFNMEPS--YDFLHIYEGEDSNSP---LIGSYQGSQAPERIESS 1534
Query: 328 SGQIRVHFCADKVNAARGF 346
+ + F +D GF
Sbjct: 1535 GNSLFLAFRSDASVGLSGF 1553
Score = 80.9 bits (198), Expect = 5e-15
Identities = 83/329 (25%), Positives = 126/329 (38%), Gaps = 66/329 (20%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 91
+ A SG+I PGWP Y ++C W I A PG I I+F F + N D L +
Sbjct: 763 LTASSGVILPPGWPGYYKDSLHCEWIIEAKPGHSIKITFDRFQTE----VNYDTLEVRDG 818
Query: 92 --ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 149
+ I Y G+ P IS+ + +++ F +D++ S GF + Y S E
Sbjct: 819 PASSSPLIGEYH--GTQAPQFLISTGNFMYLLFTTDNSRSSIGFLIHYESVTLE------ 870
Query: 150 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 209
+ C+ N GD R T
Sbjct: 871 ------SDSCLDPGIPVNGHRHGGDFG----------------------------IRSTV 896
Query: 210 VYTCLP-------ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 262
++C P E L C+ N D CG +++ GT SP +PDFYP
Sbjct: 897 TFSCDPGYTLSDDEPLVCERNHQWNHALPSCDA---LCGGYIQGKSGTVLSPGFPDFYPN 953
Query: 263 GSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKI-YDGLEENPHKLLRVLTAFDSHAP 321
NCTW I+ + V + F F L+ + DY+ I DG P + R+ + H
Sbjct: 954 SLNCTWTIEVSHGKGVQMIFHTFHLESS--HDYLLITEDGSFSEP--VARLTGSVLPHTI 1009
Query: 322 LTVVSSSGQIRVHFCADKVNAARGFNATY 350
+ + ++ F +D + GFN T+
Sbjct: 1010 KAGLFGNFTAQLRFISDFSISYEGFNITF 1038
Score = 80.1 bits (196), Expect = 8e-15
Identities = 82/321 (25%), Positives = 128/321 (39%), Gaps = 53/321 (16%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 84
+ CG T + G+I SPG+P YP ++C+W I G I F +F S
Sbjct: 1972 IATCGGTLSTL---GGVILSPGFPGSYPNNLDCTWRISLPIGYGAHIQFLNF----STEA 2024
Query: 85 NLDWLTIET---YKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 141
N D+L I+ + + + G+ +P +S+ I F+SD + +R+GF+LAY
Sbjct: 2025 NHDFLEIQNGPYHTSPMIGQFSGTDLPAALLSTTHETLIHFYSDHSQNRQGFKLAY---- 2080
Query: 142 SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 201
A + C + + N+ G S F
Sbjct: 2081 -----QAYELQNCPDPPPFQNGYMINSDYSVGQSV-----------------------SF 2112
Query: 202 QCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYP 261
+C + + + L C I+ CD P CG + GT SP +PD YP
Sbjct: 2113 ECYPGYILIGHPV---LTCQHGINRNWNYPFPRCDAP-CGYNVTSQNGTIYSPGFPDEYP 2168
Query: 262 PGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAP 321
+C WLI V + FT L DY+ ++DG ++N + L F +
Sbjct: 2169 ILKDCIWLITVPPGHGVYINFT--LLQTEAVNDYIAVWDGPDQNSPQ----LGVFSGNTA 2222
Query: 322 L-TVVSSSGQIRVHFCADKVN 341
L T SS+ Q+ + F +D N
Sbjct: 2223 LETAYSSTNQVLLKFHSDFSN 2243
Score = 72.0 bits (175), Expect = 2e-12
Identities = 83/347 (23%), Positives = 133/347 (38%), Gaps = 70/347 (20%)
Query: 37 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 96
A SGII SP +P EY +NC W I + PG I + F DFD++ D+L ++
Sbjct: 591 ASSGIILSPNYPEEYGNNMNCVWLIISEPGSRIHLIFNDFDVEP----QFDFLAVKD-DG 645
Query: 97 IESYRA----CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS-GKSE--EPNCAC 149
I G+ +P SS + + F SD + + +GF + Y + G++E +P
Sbjct: 646 ISDITVLGTFSGNEVPSQLASSGHIVRLEFQSDHSTTGRGFNITYTTFGQNECHDPGIPI 705
Query: 150 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 209
+ R G+ F + F C F K
Sbjct: 706 NGRRFGD-----------------------------------RFLLGSSVSFHCDDGFVK 730
Query: 210 VYTCLPESLKC---DGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNC 266
T ES+ C DGN+ C+ P CG L G P +P +Y +C
Sbjct: 731 --TQGSESITCILQDGNVVWSSTVPR--CEAP-CGGHLTASSGVILPPGWPGYYKDSLHC 785
Query: 267 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE--ENPHKLLRVLTAF-DSHAPLT 323
W+I+ + + F F+ + YD LE + P ++ + + AP
Sbjct: 786 EWIIEAKPGHSIKITFDRFQTEVN--------YDTLEVRDGPASSSPLIGEYHGTQAPQF 837
Query: 324 VVSSSGQIRVHFCADKVNAARGFNATYQ----VDGFCLPWEIPCGGN 366
++S+ + + F D ++ GF Y+ CL IP G+
Sbjct: 838 LISTGNFMYLLFTTDNSRSSIGFLIHYESVTLESDSCLDPGIPVNGH 884
Score = 70.5 bits (171), Expect = 6e-12
Identities = 72/323 (22%), Positives = 124/323 (38%), Gaps = 64/323 (19%)
Query: 40 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIES 99
G I SPG+P Y +NC W I G I I F + N D L I ++ +
Sbjct: 1812 GTILSPGYPEPYGNNLNCIWKIIVTEGSGIQIQVISFATEQ----NWDSLEIHDGGDVTA 1867
Query: 100 YRA---CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS---GKSEEPNCACDQFR 153
R G+T+P S+ + +++ F SD +++ GF L Y + +EP + +
Sbjct: 1868 PRLGSFSGTTVPALLNSTSNQLYLHFQSDISVAAAGFHLEYKTVGLAACQEPALPSNSIK 1927
Query: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT----K 209
G+ + + FQC +T
Sbjct: 1928 IGDRYMVNDVLS-----------------------------------FQCEPGYTLQGRS 1952
Query: 210 VYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWL 269
+C+P +++ L C + TCG L G SP +P YP +CTW
Sbjct: 1953 HISCMPGTVRRWNYPSPL-------C-IATCGGTLSTLGGVILSPGFPGSYPNNLDCTWR 2004
Query: 270 IDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD-SHAPLTVVSSS 328
I ++F +F + D+++I +G P+ ++ F + P ++S++
Sbjct: 2005 ISLPIGYGAHIQFLNFSTEAN--HDFLEIQNG----PYHTSPMIGQFSGTDLPAALLSTT 2058
Query: 329 GQIRVHFCADKVNAARGFNATYQ 351
+ +HF +D +GF YQ
Sbjct: 2059 HETLIHFYSDHSQNRQGFKLAYQ 2081
Score = 69.3 bits (168), Expect = 1e-11
Identities = 85/330 (25%), Positives = 129/330 (39%), Gaps = 68/330 (20%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 94
I+ SG + SPG+P YP +NC+W I + G+ + + F F ++ S D+L I
Sbjct: 935 IQGKSGTVLSPGFPDFYPNSLNCTWTIEVSHGKGVQMIFHTFHLESSH----DYLLITED 990
Query: 95 KNIES--YRACGSTIPPPY---ISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 149
+ R GS +P + +RF SD +IS +GF + FS EP C
Sbjct: 991 GSFSEPVARLTGSVLPHTIKAGLFGNFTAQLRFISDFSISYEGFNIT-FSEYDLEP---C 1046
Query: 150 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 209
D P AF F T
Sbjct: 1047 DD------------------------------------PGVPAFSRRIGFHFGVGDSLT- 1069
Query: 210 VYTC-LPESLKCDGNIDCLDLGDEI------DCDVPTCGQWLKYFYGTFNSPNYPDFYPP 262
++C L L+ + CL G + C V CG +K GT SPN+P Y
Sbjct: 1070 -FSCFLGYRLEGATKLTCLGGGRRVWSAPLPRC-VAECGASVKGNEGTLLSPNFPSNYDN 1127
Query: 263 GSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL 322
C + I+T + + LR F+L GD +K+YDG + + R L F + L
Sbjct: 1128 NHECIYKIETEAGKGIHLRTRSFQL---FEGDTLKVYDGKDSSS----RPLGTFTKNELL 1180
Query: 323 TVV--SSSGQIRVHFCADKVNAARGFNATY 350
++ S+S + + F + + +GF TY
Sbjct: 1181 GLILNSTSNHLWLEFNTNGSDTDQGFQLTY 1210
Score = 55.8 bits (133), Expect = 2e-07
Identities = 74/340 (21%), Positives = 125/340 (36%), Gaps = 56/340 (16%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 94
+ + +G I SPG+P EYP +C W I PG + I+F + D++ +
Sbjct: 2151 VTSQNGTIYSPGFPDEYPILKDCIWLITVPPGHGVYINFTLLQTEAVN----DYIAVWDG 2206
Query: 95 KNIESYRA---CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 151
+ S + G+T SS + + ++FHSD S GF + F A
Sbjct: 2207 PDQNSPQLGVFSGNTALETAYSSTNQVLLKFHSD--FSNGGFFVLNFH--------AFQL 2256
Query: 152 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVY 211
+C +P+A D+ F+ + ++QC +T V
Sbjct: 2257 KKCQPPPAVPQAEMLTEDDD---------------------FEIGDFVKYQCHPGYTLVG 2295
Query: 212 TCLPESLKCDGNIDCLDLGDEIDCDVPTC------GQWLKYFYGTFNSPNYPDFYPPGSN 265
T + L C L + + +PTC + G SP YP Y
Sbjct: 2296 T---DILTCK-----LSSQLQFEGSLPTCEAQCPANEVRTGSSGVILSPGYPGNYFNSQT 2347
Query: 266 CTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVV 325
C+W I + + + F+ + D ++++DG LL VL+ +
Sbjct: 2348 CSWSIKVEPNYNITIFVDTFQSE--KQFDALEVFDG-SSGQSPLLVVLSGNHTEQS-NFT 2403
Query: 326 SSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 365
S S Q+ + + D + +GF Y L + GG
Sbjct: 2404 SRSNQLYLRWSTDHATSKKGFKIRYAAPYCSLTHPLKNGG 2443
Score = 50.8 bits (120), Expect = 5e-06
Identities = 77/340 (22%), Positives = 134/340 (39%), Gaps = 71/340 (20%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 84
V CG + ++ G + SP +PS Y C + I G+ I + + F +
Sbjct: 1102 VAECGAS---VKGNEGTLLSPNFPSNYDNNHECIYKIETEAGKGIHLRTRSFQL------ 1152
Query: 85 NLDWLTIETYKNIESY-RACGSTIPPPYI-----SSQDHIWIRFHSDDNISRKGFRLAYF 138
+ T++ Y +S R G+ + S+ +H+W+ F+++ + + +GF+L Y
Sbjct: 1153 -FEGDTLKVYDGKDSSSRPLGTFTKNELLGLILNSTSNHLWLEFNTNGSDTDQGFQLTYT 1211
Query: 139 S---GKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 195
S K E+P +R DE G +D + NP +
Sbjct: 1212 SFDLVKCEDPGIPNYGYRI--------------RDE-GHFTD-TVVLYSCNP----GYAM 1251
Query: 196 CAYNQFQCLSRFTKVY-----TCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGT 250
N CLS +V+ +C+ E C G I T G+ L
Sbjct: 1252 HGSNTLTCLSGDRRVWDKPLPSCIAE---CGGQI-----------HAATSGRIL------ 1291
Query: 251 FNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLL 310
SP YP Y +CTW+I+ + + L F F D D +K++DG ++ LL
Sbjct: 1292 --SPGYPAPYDNNLHCTWIIEADPGKTISLHFIVF--DTEMAHDILKVWDGPVDS-DILL 1346
Query: 311 RVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 350
+ + S P + S+ + + F +D + GF+ +
Sbjct: 1347 KEWSG--SALPEDIHSTFNSLTLQFDSDFFISKSGFSIQF 1384
Score = 47.0 bits (110), Expect = 7e-05
Identities = 72/325 (22%), Positives = 122/325 (37%), Gaps = 45/325 (13%)
Query: 34 QIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIET 93
Q G++ SP +P Y A C + I ++ F F + L T
Sbjct: 1629 QYTGSEGVVLSPNYPHNYTAGQICLYSITVPKEFVVFGQFAYFQTALNDLAELFDGTHAQ 1688
Query: 94 YKNIESYRAC--GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS-GKSEEPNCACD 150
+ + S G T+P +++ + I +RF + S +GF Y + ++ + C+
Sbjct: 1689 ARLLSSLSGSHSGETLP---LATSNQILLRFSAKSGASARGFHFVYQAVPRTSDTQCSS- 1744
Query: 151 QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKV 210
+PE + + S I E NP + C S
Sbjct: 1745 ---------VPEPRYGRRIGS--EFSAGSIVRFECNP----GYLLQGSTALHCQS----- 1784
Query: 211 YTCLPESLKCDGNIDCLDLGDEI-DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWL 269
+P +L D I C VP G + + GT SP YP+ Y NC W
Sbjct: 1785 ---VPNALA--------QWNDTIPSCVVPCSGNFTQR-RGTILSPGYPEPYGNNLNCIWK 1832
Query: 270 IDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSG 329
I + + ++ F + D ++I+DG + R+ + + P + S+S
Sbjct: 1833 IIVTEGSGIQIQVISFATEQN--WDSLEIHDGGDVTAP---RLGSFSGTTVPALLNSTSN 1887
Query: 330 QIRVHFCADKVNAARGFNATYQVDG 354
Q+ +HF +D AA GF+ Y+ G
Sbjct: 1888 QLYLHFQSDISVAAAGFHLEYKTVG 1912
>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
sapiens]
Length = 986
Score = 107 bits (268), Expect = 4e-23
Identities = 87/333 (26%), Positives = 137/333 (41%), Gaps = 75/333 (22%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 98
+G ITSPGWP EYP NC W + A I++ F F+ +G+ C D++ + + +
Sbjct: 599 NGSITSPGWPKEYPPNKNCIWQLVAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTAD 658
Query: 99 SY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 155
S + CGS P S +++ + F SD+ +S+KGF+ +FS K E C+ D
Sbjct: 659 SKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDE---CSKD----- 710
Query: 156 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 215
NG C + EC QC S F
Sbjct: 711 NGGCQQDCVNTFGSYEC-----------------------------QCRSGF-------- 733
Query: 216 ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDH 275
+ D DC + G C + GT SPN+PD YP CTW I +
Sbjct: 734 --VLHDNKHDCKEAG---------CDHKVTSTSGTITSPNWPDKYPSKKECTWAISSTPG 782
Query: 276 RKVILRFTDFKLDG---TGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIR 332
+V L F + ++ Y D+++++DG + L R S P V+++ ++
Sbjct: 783 HRVKLTFMEMDIESQPECAY-DHLEVFDGRDAKAPVLGRFC---GSKKPEPVLATGSRMF 838
Query: 333 VHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 365
+ F +D +GF A++ + CGG
Sbjct: 839 LRFYSDNSVQRKGFQASHATE---------CGG 862
Score = 90.5 bits (223), Expect = 6e-18
Identities = 82/355 (23%), Positives = 134/355 (37%), Gaps = 73/355 (20%)
Query: 35 IRAPSGIITSPGWPSEY-PAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIET 93
++ G I SP +P +Y P+K+ C W I+ + G + ++FQ F+I+ C D+L +
Sbjct: 439 VKKDYGHIQSPNYPDDYRPSKV-CIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRD 497
Query: 94 YKNIESY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACD 150
+ S R CG P S+ +W++F SD +I++ GF + +F
Sbjct: 498 GHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFF------------ 545
Query: 151 QFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKV 210
+DEC + P Q C
Sbjct: 546 ----------------KEVDEC------------SRPNRGGCEQRCLNTLGSYKCSCDPG 577
Query: 211 YTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLI 270
Y P+ +C+ CG +L G+ SP +P YPP NC W +
Sbjct: 578 YELAPDKRRCEA----------------ACGGFLTKLNGSITSPGWPKEYPPNKNCIWQL 621
Query: 271 DTGDHRKVILRFTDFKLDGTGY--GDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSS 328
++ L+F F+ +G D+V++ GL + KL S P + S
Sbjct: 622 VAPTQYRISLQFDFFETEGNDVCKYDFVEVRSGLTAD-SKLHGKFCG--SEKPEVITSQY 678
Query: 329 GQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCG-GNWGCYTEQQRCDGYWHC 382
+RV F +D + +GF A + D + C N GC + G + C
Sbjct: 679 NNMRVEFKSDNTVSKKGFKAHFFSD------KDECSKDNGGCQQDCVNTFGSYEC 727
Score = 85.1 bits (209), Expect = 2e-16
Identities = 36/107 (33%), Positives = 66/107 (61%), Gaps = 3/107 (2%)
Query: 34 QIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIET 93
++ + SG ITSP WP +YP+K C+W I + PG + ++F + DI+ C D L +
Sbjct: 750 KVTSTSGTITSPNWPDKYPSKKECTWAISSTPGHRVKLTFMEMDIESQPECAYDHLEVFD 809
Query: 94 YKNIES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 137
++ ++ R CGS P P +++ +++RF+SD+++ RKGF+ ++
Sbjct: 810 GRDAKAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASH 856
Score = 75.1 bits (183), Expect = 3e-13
Identities = 40/114 (35%), Positives = 59/114 (51%), Gaps = 6/114 (5%)
Query: 27 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 86
ACGET ++ +G +SP +P+ Y A ++C W I PGE I ++F D+ SR C
Sbjct: 321 ACGET---LQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWY 377
Query: 87 DWLTIET---YKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 137
D++ + K R CGS +P P +S+ +W+ F S N KGF Y
Sbjct: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY 431
Score = 67.4 bits (163), Expect = 5e-11
Identities = 34/101 (33%), Positives = 54/101 (53%), Gaps = 7/101 (6%)
Query: 49 SEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESY-----RAC 103
+ YP ++C W I A G + + FQ F+++ C D++ E + +S R C
Sbjct: 882 NNYPGGVDCEWVIVAEEGYGVELVFQTFEVEEETDCGYDYM--ELFDGYDSTAPRLGRYC 939
Query: 104 GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEE 144
GS P S+ D + ++FHSDD I++KGF L Y S K ++
Sbjct: 940 GSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRYTSTKFQD 980
Score = 56.2 bits (134), Expect = 1e-07
Identities = 40/131 (30%), Positives = 56/131 (42%), Gaps = 14/131 (10%)
Query: 238 PTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL--DGTGYGDY 295
P CG+ L+ G F+SP YP+ Y +C W I K+IL FT L + DY
Sbjct: 320 PACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSLDLYRSRLCWYDY 379
Query: 296 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGF 355
V++ DG R S P +VS+ ++ V F + +GF A Y
Sbjct: 380 VEVRDGFWRKAPLRGRFC---GSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVY----- 431
Query: 356 CLPWEIPCGGN 366
E CGG+
Sbjct: 432 ----EAICGGD 438
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/142 (30%), Positives = 61/142 (42%), Gaps = 18/142 (12%)
Query: 240 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL---DGTGYGDYV 296
CG +K YG SPNYPD Y P C W I + V L F F++ D Y DY+
Sbjct: 435 CGGDVKKDYGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAY-DYL 493
Query: 297 KIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY--QVDG 354
++ DG E+ + R P + S+S ++ + F +D GF + +VD
Sbjct: 494 EVRDGHSESSTLIGRYC---GYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNFFKEVDE 550
Query: 355 FCLPWEIPCGGNWGCYTEQQRC 376
P GC +QRC
Sbjct: 551 CSRP------NRGGC---EQRC 563
Score = 42.4 bits (98), Expect = 0.002
Identities = 35/126 (27%), Positives = 56/126 (44%), Gaps = 14/126 (11%)
Query: 228 DLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL 287
+ G ++ DV T Y + F NYP G +C W+I + V L F F++
Sbjct: 859 ECGGQVRADVKTKDL---YSHAQFGDNNYPG----GVDCEWVIVAEEGYGVELVFQTFEV 911
Query: 288 D---GTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAAR 344
+ GY DY++++DG + +L R S P V S+ + V F +D +
Sbjct: 912 EEETDCGY-DYMELFDGYDSTAPRLGRYC---GSGPPEEVYSAGDSVLVKFHSDDTITKK 967
Query: 345 GFNATY 350
GF+ Y
Sbjct: 968 GFHLRY 973
>gi|92110053 CUB and Sushi multiple domains 2 [Homo sapiens]
Length = 3487
Score = 102 bits (253), Expect = 2e-21
Identities = 101/358 (28%), Positives = 159/358 (44%), Gaps = 47/358 (13%)
Query: 27 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 86
ACG T +R SGII+SP +PSEY +C+W I A G+ I + F DF ++
Sbjct: 201 ACGGT---LRGQSGIISSPHFPSEYHNNADCTWTILAELGDTIALVFIDFQLED----GY 253
Query: 87 DWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPN 146
D+L + T S G+++P P ISS++ + + F SD N ++GF Y K E
Sbjct: 254 DFLEV-TGTEGSSLWFTGASLPAPVISSKNWLRLHFTSDGNHRQRGFSAQYQVKKQIE-- 310
Query: 147 CACDQFRCGNGKCIP---EAWKCNNMDECGDSSDEEICAKEANPP----TAAAFQPCAYN 199
+ K +P + K + + + G S +C P + F+ +
Sbjct: 311 -----LKSRGVKLMPSKDNSQKTSVLTQVGVSQGHNMCPDPGIPERGKRLGSDFRLGSSV 365
Query: 200 QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID--------CDVPTCGQWLKYFYGTF 251
QF C + L+ I C+ + D C C L+ G
Sbjct: 366 QFTCNEGY---------DLQGSKRITCMKVSDMFAAWSDHRPVCRARMCDAHLRGPSGII 416
Query: 252 NSPNYPDFYPPGSNCTWLIDTGDHRKVI-LRFTDFKLDGTGYGDYVKIYDGLEENPHK-L 309
SPN+P Y ++C W+I + KVI L F +F L+ GY D + + DG ++ K +
Sbjct: 417 TSPNFPIQYDNNAHCVWIITALNPSKVIKLAFEEFDLE-RGY-DTLTVGDGGQDGDQKTV 474
Query: 310 LRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ--VDGFCLPWEIPCGG 365
L +LT + P +VS++ Q+ + F D ++ GF A+Y+ G C IP G
Sbjct: 475 LYILTG--TSVPDLIVSTNHQMWLLFQTDGSGSSLGFKASYEEIEQGSCGDPGIPAYG 530
Score = 95.9 bits (237), Expect = 1e-19
Identities = 89/321 (27%), Positives = 135/321 (42%), Gaps = 50/321 (15%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 91
+ +PSG I SPGWP Y ++C+W I A PG I I+F F + N D L +
Sbjct: 756 LTSPSGTILSPGWPGFYKDALSCAWVIEAQPGYPIKITFDRFKTE----VNYDTLEVRDG 811
Query: 92 ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 151
TY G+ +P IS+ +++++ F +D + S GF+L Y +
Sbjct: 812 RTYSAPLIGVYHGTQVPQFLISTSNYLYLLFSTDKSHSDIGFQLRY------------ET 859
Query: 152 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVY 211
+ C+ N D F A F C S +T
Sbjct: 860 ITLQSDHCLDPGIPVNGQRHGND------------------FYVGALVTFSCDSGYT--- 898
Query: 212 TCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLID 271
E L+C+ N + CG +++ GT SP +PDFYP NCTW+I+
Sbjct: 899 LSDGEPLECEPN---FQWSRALPSCEALCGGFIQGSSGTILSPGFPDFYPNNLNCTWIIE 955
Query: 272 TGDHRKVILRFTDFKLDGTGYGDYVKIYD-GLEENPHKLLRVLTAFDSHAPLTV-VSSSG 329
T + V F F L+ +G+ DY+ I + G P LR LT AP++ + +
Sbjct: 956 TSHGKGVFFTFHTFHLE-SGH-DYLLITENGSFTQP---LRQLTGSRLPAPISAGLYGNF 1010
Query: 330 QIRVHFCADKVNAARGFNATY 350
+V F +D + GFN T+
Sbjct: 1011 TAQVRFISDFSMSYEGFNITF 1031
Score = 80.1 bits (196), Expect = 8e-15
Identities = 86/332 (25%), Positives = 135/332 (40%), Gaps = 68/332 (20%)
Query: 34 QIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI-- 91
Q+ P+G + SPG+P YP NC+W I A I + FQ F ++ + D L++
Sbjct: 29 QLHGPNGTVESPGFPYGYPNYANCTWTITAEEQHRIQLVFQSFALEE----DFDVLSVFD 84
Query: 92 --ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 149
+N+ + R G +P +S+ + +R SD +S +GF Y
Sbjct: 85 GPPQPENLRT-RLTGFQLPATIVSAATTLSLRLISDYAVSAQGFHATYE---------VL 134
Query: 150 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRF-- 207
CGN +P + + GD ++ C F
Sbjct: 135 PSHTCGNPGRLPNGIQQGSTFNLGDKV-----------------------RYSCNLGFFL 171
Query: 208 --TKVYTC---LPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPP 262
V TC S D + D CG L+ G +SP++P Y
Sbjct: 172 EGHAVLTCHAGSENSATWDFPLPSCRADD-------ACGGTLRGQSGIISSPHFPSEYHN 224
Query: 263 GSNCTW--LIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHA 320
++CTW L + GD + L F DF+L+ GY D++++ G E + L +
Sbjct: 225 NADCTWTILAELGD--TIALVFIDFQLE-DGY-DFLEV-TGTEGSS------LWFTGASL 273
Query: 321 PLTVVSSSGQIRVHFCADKVNAARGFNATYQV 352
P V+SS +R+HF +D + RGF+A YQV
Sbjct: 274 PAPVISSKNWLRLHFTSDGNHRQRGFSAQYQV 305
Score = 79.3 bits (194), Expect = 1e-14
Identities = 89/327 (27%), Positives = 137/327 (41%), Gaps = 35/327 (10%)
Query: 28 CGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLD 87
CG T E++ G+I SPG+P YP+ ++CSW I G I F +F S N D
Sbjct: 1968 CGGTVEEME---GVILSPGFPGNYPSNMDCSWKIALPVGFGAHIQFLNF----STEPNHD 2020
Query: 88 WLTIET--YKNIESY-RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY----FSG 140
++ I Y+ R GS +P +S+ + FHSD + +R GF+L Y +S
Sbjct: 2021 YIEIRNGPYETSRMMGRFSGSELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQDLTYSH 2080
Query: 141 KSEEPNCACDQFRCGNGKCIP--EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 198
+ D P A ++D ++ + + C + P + Y
Sbjct: 2081 QISSFLRGFDLSELERTNSTPPVAASYVWDLDPGCEAYELQEC-PDPEPFANGIVRGAGY 2139
Query: 199 NQFQCLSRFTKVYTCLP-------ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTF 251
N Q ++ + CLP L C + C+VP CG + GT
Sbjct: 2140 NVGQSVT-----FECLPGYQLTGHPVLTCQHGTNRNWDHPLPKCEVP-CGGNITSSNGTV 2193
Query: 252 NSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLR 311
SP +P Y +C WLI V L + + + + GD++ I+DG ++ + L
Sbjct: 2194 YSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPS--GDFITIWDGPQQTAPR-LG 2250
Query: 312 VLTAFDSHAPLTVVSSSGQIRVHFCAD 338
V T S A TV SSS Q+ + F D
Sbjct: 2251 VFTR--SMAKKTVQSSSNQVLLKFHRD 2275
Score = 75.5 bits (184), Expect = 2e-13
Identities = 81/321 (25%), Positives = 124/321 (38%), Gaps = 59/321 (18%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 98
SG + SPG+P+ Y +NC W I A G I + F FD + W +
Sbjct: 1280 SGQVLSPGYPAPYEHNLNCIWTIEAEAGCTIGLHFLVFDTEEVHDVLRIW-DGPVESGVL 1338
Query: 99 SYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGK 158
G +P S+ + + ++F +D S++GF + + + N D NG
Sbjct: 1339 LKELSGPALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSVSTATSCN---DPGIPQNGS 1395
Query: 159 CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPE-S 217
++W E GDS+ V+ C P +
Sbjct: 1396 RSGDSW------EAGDST---------------------------------VFQCDPGYA 1416
Query: 218 LKCDGNIDCLDLGDEI-------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLI 270
L+ I C+ + + C P CG L G SPNYP+ YPPG C W +
Sbjct: 1417 LQGSAEISCVKIENRFFWQPSPPTCIAP-CGGDLTGPSGVILSPNYPEPYPPGKECDWKV 1475
Query: 271 DTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVSSSG 329
+ L F F L+ GY D++ IYDG + L ++ +F S P + SSS
Sbjct: 1476 TVSPDYVIALVFNIFNLE-PGY-DFLHIYDGRD----SLSPLIGSFYGSQLPGRIESSSN 1529
Query: 330 QIRVHFCADKVNAARGFNATY 350
+ + F +D + GF Y
Sbjct: 1530 SLFLAFRSDASVSNAGFVIDY 1550
Score = 73.9 bits (180), Expect = 6e-13
Identities = 78/341 (22%), Positives = 131/341 (38%), Gaps = 60/341 (17%)
Query: 37 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 96
+PSG++ SP +P +Y ++C W I A P I ++F D D++ D+L I+
Sbjct: 584 SPSGVVLSPNYPEDYGNHLHCVWLILARPESRIHLAFNDIDVEP----QFDFLVIKDGAT 639
Query: 97 IES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 153
E+ G+ +P SS + F +D + ++GF + + + + E
Sbjct: 640 AEAPVLGTFSGNQLPSSITSSGHVARLEFQTDHSTGKRGFNITFTTFRHNE--------- 690
Query: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRF-----T 208
P+ N GDS Q + F C F +
Sbjct: 691 ------CPDPGVPVNGKRFGDS-----------------LQLGSSISFLCDEGFLGTQGS 727
Query: 209 KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTW 268
+ TC+ + N L C+ P CG L GT SP +P FY +C W
Sbjct: 728 ETITCVLKEGSVVWNSAVL------RCEAP-CGGHLTSPSGTILSPGWPGFYKDALSCAW 780
Query: 269 LIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSS 328
+I+ + + F FK + Y D +++ DG + + + P ++S+S
Sbjct: 781 VIEAQPGYPIKITFDRFKTE-VNY-DTLEVRDG---RTYSAPLIGVYHGTQVPQFLISTS 835
Query: 329 GQIRVHFCADKVNAARGFNATYQV----DGFCLPWEIPCGG 365
+ + F DK ++ GF Y+ CL IP G
Sbjct: 836 NYLYLLFSTDKSHSDIGFQLRYETITLQSDHCLDPGIPVNG 876
Score = 72.8 bits (177), Expect = 1e-12
Identities = 81/323 (25%), Positives = 127/323 (39%), Gaps = 62/323 (19%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 94
I+ SG I SPG+P YP +NC+W I + G+ + +F F ++ D+L I
Sbjct: 928 IQGSSGTILSPGFPDFYPNNLNCTWIIETSHGKGVFFTFHTFHLESGH----DYLLITEN 983
Query: 95 KNIES--YRACGSTIPPPY---ISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 149
+ + GS +P P + +RF SD ++S +GF + FS EP C
Sbjct: 984 GSFTQPLRQLTGSRLPAPISAGLYGNFTAQVRFISDFSMSYEGFNIT-FSEYDLEP---C 1039
Query: 150 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 209
++ P A+ QF T
Sbjct: 1040 EE------------------------------------PEVPAYSIRKGLQFGVGDTLT- 1062
Query: 210 VYTCLP-ESLKCDGNIDCLD-----LGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 263
++C P L+ I CL + V CG + GT SPN+P Y
Sbjct: 1063 -FSCFPGYRLEGTARITCLGGRRRLWSSPLPRCVAECGNSVTGTQGTLLSPNFPVNYNNN 1121
Query: 264 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 323
C + I T + + L+ F+L GD +K+YDG N +LL V + + +T
Sbjct: 1122 HECIYSIQTQPGKGIQLKARAFEL---SEGDVLKVYDG-NNNSARLLGVFSHSEMMG-VT 1176
Query: 324 VVSSSGQIRVHFCADKVNAARGF 346
+ S+S + + F D N ++GF
Sbjct: 1177 LNSTSSSLWLDFITDAENTSKGF 1199
Score = 68.9 bits (167), Expect = 2e-11
Identities = 76/334 (22%), Positives = 130/334 (38%), Gaps = 59/334 (17%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 84
V CG + R G I SPG+P Y +NC W I G I I F + +
Sbjct: 1793 VVPCGGNLTERR---GTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN--- 1846
Query: 85 NLDWLTIETYKNIESYRAC-----GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS 139
W ++E + ++ G+T+P S+ + +++ F+SD ++S GF L Y +
Sbjct: 1847 ---WDSLEVFDGADNTVTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKT 1903
Query: 140 -GKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 198
G S P A NG E + N ++ + + P A +
Sbjct: 1904 VGLSSCPEPAVP----SNGVKTGERYLVN-----------DVVSFQCEPGYALQ----GH 1944
Query: 199 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPD 258
C+ + + P + CG ++ G SP +P
Sbjct: 1945 AHISCMPGTVRRWNYPPPLC------------------IAQCGGTVEEMEGVILSPGFPG 1986
Query: 259 FYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD- 317
YP +C+W I ++F +F + DY++I +G P++ R++ F
Sbjct: 1987 NYPSNMDCSWKIALPVGFGAHIQFLNFSTEPN--HDYIEIRNG----PYETSRMMGRFSG 2040
Query: 318 SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 351
S P +++S+S + V+F +D GF YQ
Sbjct: 2041 SELPSSLLSTSHETTVYFHSDHSQNRPGFKLEYQ 2074
Score = 54.7 bits (130), Expect = 4e-07
Identities = 35/120 (29%), Positives = 57/120 (47%), Gaps = 15/120 (12%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 94
+ PSG+I SP +P YP C W + +P +I + F F+++ D+L I Y
Sbjct: 1449 LTGPSGVILSPNYPEPYPPGKECDWKVTVSPDYVIALVFNIFNLEP----GYDFLHI--Y 1502
Query: 95 KNIESYRAC-----GSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 149
+S GS +P SS + +++ F SD ++S GF + Y +E P +C
Sbjct: 1503 DGRDSLSPLIGSFYGSQLPGRIESSSNSLFLAFRSDASVSNAGFVIDY----TENPRESC 1558
Score = 51.2 bits (121), Expect = 4e-06
Identities = 77/331 (23%), Positives = 123/331 (37%), Gaps = 52/331 (15%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 91
I + +G + SPG+PS Y + +C W I G + ++ + S D++TI
Sbjct: 2186 ITSSNGTVYSPGFPSPYSSSQDCVWLITVPIGHGVRLNLSLLQTEPSG----DFITIWDG 2241
Query: 92 --ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 149
+T + + S SS + + ++FH D + G FS A
Sbjct: 2242 PQQTAPRLGVFTR--SMAKKTVQSSSNQVLLKFHRD--AATGGIFAIAFS--------AY 2289
Query: 150 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 209
+C +P A +E F +++CL FT
Sbjct: 2290 PLTKCPPPTILPNAEVVTENEE---------------------FNIGDIVRYRCLPGFTL 2328
Query: 210 VYTCLPESLKCDGNIDCLDLGDEIDCDV--PTCGQWLKYFYGTFNSPNYPDFYPPGSNCT 267
V E L C G C+V PT + L G S +YP YP C+
Sbjct: 2329 VGN---EILTCKLGTYLQFEGPPPICEVHCPT-NELLTDSTGVILSQSYPGSYPQFQTCS 2384
Query: 268 WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSS 327
WL+ + L ++ L Y ++ +I+DG LL+ L+ + APL V SS
Sbjct: 2385 WLVRVEPDYNISLT-VEYFLSEKQYDEF-EIFDG-PSGQSPLLKALSG-NYSAPLIVTSS 2440
Query: 328 SGQIRVHFCADKVNAARGFNATYQVDGFCLP 358
S + + + +D +GF Y LP
Sbjct: 2441 SNSVYLRWSSDHAYNRKGFKIRYSAPYCSLP 2471
Score = 47.4 bits (111), Expect = 6e-05
Identities = 37/134 (27%), Positives = 62/134 (46%), Gaps = 10/134 (7%)
Query: 235 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 294
C VP CG L GT SP +P+ Y NC W I + + ++ F + D
Sbjct: 1792 CVVP-CGGNLTERRGTILSPGFPEPYLNSLNCVWKIVVPEGAGIQIQVVSFVTEQN--WD 1848
Query: 295 YVKIYDGLEENPHKLLRVLTAFD-SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVD 353
++++DG + + +L +F + P + S+S Q+ +HF +D +A GF+ Y+
Sbjct: 1849 SLEVFDGADNT----VTMLGSFSGTTVPALLNSTSNQLYLHFYSDISVSAAGFHLEYKTV 1904
Query: 354 GF--CLPWEIPCGG 365
G C +P G
Sbjct: 1905 GLSSCPEPAVPSNG 1918
Score = 47.4 bits (111), Expect = 6e-05
Identities = 35/143 (24%), Positives = 57/143 (39%), Gaps = 24/143 (16%)
Query: 31 TPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLT 90
T E + +G+I S +P YP CSW +R P I+++ + F L+
Sbjct: 2357 TNELLTDSTGVILSQSYPGSYPQFQTCSWLVRVEPDYNISLTVEYF------------LS 2404
Query: 91 IETYKNIESY----------RACGSTIPPPYI--SSQDHIWIRFHSDDNISRKGFRLAYF 138
+ Y E + +A P I SS + +++R+ SD +RKGF++ Y
Sbjct: 2405 EKQYDEFEIFDGPSGQSPLLKALSGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYS 2464
Query: 139 SGKSEEPNCACDQFRCGNGKCIP 161
+ P F G P
Sbjct: 2465 APYCSLPRAPLHGFILGQTSTQP 2487
Score = 46.6 bits (109), Expect = 1e-04
Identities = 35/117 (29%), Positives = 55/117 (47%), Gaps = 6/117 (5%)
Query: 235 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 294
C P GQ++ G SPNYP Y G C + + K + F F T D
Sbjct: 1615 CTAPCGGQYVGSD-GVVLSPNYPQNYTSGQICLYFVTV---PKDYVVFGQFAFFHTALND 1670
Query: 295 YVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 351
V+++DG ++ +LL L+ + L +++S Q+ + F A + ARGF+ YQ
Sbjct: 1671 VVEVHDGHSQH-SRLLSSLSGSHTGESLP-LATSNQVLIKFSAKGLAPARGFHFVYQ 1725
Score = 39.7 bits (91), Expect = 0.012
Identities = 72/338 (21%), Positives = 119/338 (35%), Gaps = 63/338 (18%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 84
V CG + + G + SP +P Y C + I+ PG+ I + + F++
Sbjct: 1095 VAECGNS---VTGTQGTLLSPNFPVNYNNNHECIYSIQTQPGKGIQLKARAFELSEG--- 1148
Query: 85 NLDWLTIETYKNIESYRACG-----STIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS 139
D L + N S R G + S+ +W+ F +D + KGF L + S
Sbjct: 1149 --DVLKVYDGNN-NSARLLGVFSHSEMMGVTLNSTSSSLWLDFITDAENTSKGFELHFSS 1205
Query: 140 GKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN 199
+ +C + +K ++ SS C +
Sbjct: 1206 ---------FELIKCEDPGTPKFGYKVHDEGHFAGSSVSFSCDP--------GYSLRGSE 1248
Query: 200 QFQCLSRFTKVY-----TCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSP 254
+ CLS + + TC+ E C G + E+ G SP
Sbjct: 1249 ELLCLSGERRTWDRPLPTCVAE---CGGTVR-----GEVS--------------GQVLSP 1286
Query: 255 NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 314
YP Y NC W I+ + L F F D D ++I+DG E+ LL+ L+
Sbjct: 1287 GYPAPYEHNLNCIWTIEAEAGCTIGLHFLVF--DTEEVHDVLRIWDGPVES-GVLLKELS 1343
Query: 315 AFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQV 352
P + S+ + + F D + +GF + V
Sbjct: 1344 G--PALPKDLHSTFNSVVLQFSTDFFTSKQGFAIQFSV 1379
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 95.5 bits (236), Expect = 2e-19
Identities = 90/397 (22%), Positives = 156/397 (39%), Gaps = 75/397 (18%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 98
SG SP +P Y C W+++++ G + F+DF ++ C LD+L + +
Sbjct: 1173 SGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLAVYDGPSSN 1232
Query: 99 SY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFR--------------------- 134
S+ + CG PP SS D ++I+ +D+ +GF+
Sbjct: 1233 SHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYRQTCENVVIVNQTYGILE 1292
Query: 135 -LAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI------------C 181
+ Y + SE +C R G + + +++ + S + + C
Sbjct: 1293 SIGYPNPYSENQHCNWT-IRATTGNTVNYTFLAFDLEHHINCSTDYLELYDGPRQMGRYC 1351
Query: 182 AKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCG 241
+ PP + ++ Q L L DG + + G ++ V CG
Sbjct: 1352 GVDLPPPGSTTS-----SKLQVL-------------LLTDG-VGRREKGFQMQWFVYGCG 1392
Query: 242 QWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD--GTGYGDYVKIY 299
L G+F+SP +P+ YPP C W I T + L DF ++ D ++IY
Sbjct: 1393 GELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIY 1452
Query: 300 DGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPW 359
G + + ++ ++ T P+ V S+ ++ + F D RGFNA+ W
Sbjct: 1453 GGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNAS---------W 1503
Query: 360 EIPCGGNWGCYTEQQRCDGYWHCPN----GRDETNCT 392
+ GG G + Q G H PN R T+C+
Sbjct: 1504 QAVTGGCGGIF---QAPSGEIHSPNYPSPYRSNTDCS 1537
Score = 91.3 bits (225), Expect = 3e-18
Identities = 96/376 (25%), Positives = 160/376 (42%), Gaps = 59/376 (15%)
Query: 27 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 86
ACG+ G+I SP +P+ YP + C W I ++I ++F F+I S C
Sbjct: 816 ACGDE----LTGEGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCET 871
Query: 87 DWLTIETYKNI---ESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSE 143
D++ I + + E+ + CG+ IP S + +++ F + GF +A FS +
Sbjct: 872 DYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGF-MAKFSAE-- 928
Query: 144 EPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN-QFQ 202
+ AC + + I N G + I + N F+ +
Sbjct: 929 --DLACGEILTESTGTIQSPGHPNVYPH-GINCTWHILV-QPNHLIHLMFETFHLEFHYN 984
Query: 203 CLSRFTKVYTC-------------LPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYF-- 247
C + + +VY +P SL GN L L D D+ G + Y
Sbjct: 985 CTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGN--SLMLVFVTDSDLAYEGFLINYEAI 1042
Query: 248 -------------YGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD---GTG 291
GTF SPN+P+ YP C + I + + + FT+F L+ G
Sbjct: 1043 SAATACLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEEAIGNY 1102
Query: 292 YGDYVKIYD-GLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 350
Y D+++I D G E++P LL + + S+ P T++S S ++ + F +D+++ GF+A +
Sbjct: 1103 YTDFLEIRDGGYEKSP--LLGIF--YGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYW 1158
Query: 351 QVDGFCLPWEIPCGGN 366
DG CGGN
Sbjct: 1159 --DGS----STGCGGN 1168
Score = 89.0 bits (219), Expect = 2e-17
Identities = 85/348 (24%), Positives = 133/348 (38%), Gaps = 48/348 (13%)
Query: 36 RAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYK 95
+APSG I SP +PS Y + +CSW IR + + ++F DFD++ C I Y
Sbjct: 1515 QAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLEPQDSC------IMAYD 1568
Query: 96 NIES-----YRACG-STIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSG--------- 140
+ S R CG + P +SS + +++RF S + +GFR +
Sbjct: 1569 GLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFRQACGGHILTSS 1628
Query: 141 --KSEEPNCACDQFRCGNGKCIPEA-------------WKCNNMDECGDSSDEEICAKEA 185
P + N I +A ++ C E +
Sbjct: 1629 FDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFTHFELERSTTCARDFVEILDGGHE 1688
Query: 186 NPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLK 245
+ P + C + ++ F+ T D +I + V CG
Sbjct: 1689 DAPLRGRY--CGTDMPHPITSFSSALTL---RFVSDSSISAGGFHTTVTASVSACGGTFY 1743
Query: 246 YFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTG--YGDYVKIYDGLE 303
G FNSP YPD YPP C W I + ++ L F F+L+ + D+V+I +G
Sbjct: 1744 MAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQDCSRDFVEIREG-N 1802
Query: 304 ENPHKLLRVLTAFDSHAPLTVVSSSGQ-IRVHFCADKVNAARGFNATY 350
H + R + PL S G + V F +D + GF AT+
Sbjct: 1803 ATGHLVGRYC---GNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATF 1847
Score = 84.0 bits (206), Expect = 5e-16
Identities = 84/337 (24%), Positives = 132/337 (39%), Gaps = 33/337 (9%)
Query: 40 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIES 99
GI+ S G+P+ Y +C+W IRA G + +F FD++ C+ D+L E Y
Sbjct: 1289 GILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEHHINCSTDYL--ELYDGPRQ 1346
Query: 100 Y-RACGSTIPPPYISSQDHIWIRFHSDDNISR-KGFRLAYF--------SGKSEE----- 144
R CG +PPP ++ + + +D R KGF++ +F SG +
Sbjct: 1347 MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGELSGATGSFSSPG 1406
Query: 145 ------PNCACDQF-RCGNGKCIP---EAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ 194
PN C + R G I + C E + + P A Q
Sbjct: 1407 FPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRCNFDVLEIYGGPDFHSPRIA--Q 1464
Query: 195 PCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSP 254
C + + + L K D +I+ CG + G +SP
Sbjct: 1465 LCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVTGGCGGIFQAPSGEIHSP 1524
Query: 255 NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 314
NYP Y ++C+W+I + +V+L FTDF L+ + YDGL +L R T
Sbjct: 1525 NYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLE--PQDSCIMAYDGLSSTMSRLAR--T 1580
Query: 315 AFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 351
+VSS + + F + RGF A ++
Sbjct: 1581 CGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRAQFR 1617
Score = 84.0 bits (206), Expect = 5e-16
Identities = 91/384 (23%), Positives = 150/384 (39%), Gaps = 85/384 (22%)
Query: 27 ACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNL 86
ACG AP + SPGWP Y +++C+W I+A P + ++ DI+ R C
Sbjct: 1977 ACGGFLRTGDAPV-FLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIESHRTCAY 2034
Query: 87 DWLTIETYKNIESYRA---CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYF----- 138
D L I N + + CG IP P S+ ++++IRF SD +++R GF ++
Sbjct: 2035 DSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFHKSCGG 2094
Query: 139 ----------SGKSEEP-----NCAC---------------DQFRCGNGKCIPEAWKCNN 168
S K E NC+ F+ NG CN
Sbjct: 2095 YLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDS-----SCNQ 2149
Query: 169 MDECGDSSDEEICAKEANPP-------TAAAFQPCAYNQFQCLSRFTKVYT--------- 212
D + +IC+ PP + A + Q +F ++
Sbjct: 2150 GDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIK 2209
Query: 213 CLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDT 272
+SL C GN+ D G SPN+P YPP ++C W++
Sbjct: 2210 YEAKSLACGGNVYIHDADSA----------------GYVTSPNHPHNYPPHADCIWILAA 2253
Query: 273 GDHRKVILRFTD-FKLDGTG--YGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVSSS 328
++ L+F D F ++ T +Y+++ DG++ + +L+ F + P + SS
Sbjct: 2254 PPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDSD----APILSKFCGTSLPSSQWSSG 2309
Query: 329 GQIRVHFCADKVNAARGFNATYQV 352
+ + F +D GF A Y +
Sbjct: 2310 EVMYLRFRSDNSPTHVGFKAKYSI 2333
Score = 83.2 bits (204), Expect = 9e-16
Identities = 77/339 (22%), Positives = 147/339 (43%), Gaps = 32/339 (9%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQD-FDIQGSRRCNLDWLTIETYKNI 97
+G +TSP P YP +C W + A P I + F+D FDI+ + C ++L + +
Sbjct: 2229 AGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDRFDIEVTPNCTSNYLELRDGVDS 2288
Query: 98 ES---YRACGSTIPPPYISSQDHIWIRFHSDDN-----------ISRKGFRLAYFSGKSE 143
++ + CG+++P SS + +++RF SD++ I++ G R+ SG E
Sbjct: 2289 DAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSIAQCGGRVPGQSGVVE 2348
Query: 144 E---------PNCACDQFRCG-NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAF 193
N C+ G +G + +++ N+ + + + +
Sbjct: 2349 SIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGCEKDFVEIWDNHTSGNILG 2408
Query: 194 QPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNS 253
+ C + T T + + DG++ + + CG L+ GTF S
Sbjct: 2409 RYCGNTIPDSID--TSSNTAVVRFVT-DGSVTASGFRLRFESSMEECGGDLQGSIGTFTS 2465
Query: 254 PNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL--DGTGYGDYVKIYDGLEENPHKLLR 311
PNYP+ P G C W I + R++ L F + +L + ++V +++G+ N +L +
Sbjct: 2466 PNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHPSCNNEHVIVFNGIRSNSPQLEK 2525
Query: 312 VLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 350
+ ++ + + SS ++V F D GF A+Y
Sbjct: 2526 LCSSV--NVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY 2562
Score = 81.6 bits (200), Expect = 3e-15
Identities = 71/293 (24%), Positives = 116/293 (39%), Gaps = 39/293 (13%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIE-- 92
+ P G I SPG+P YP +C W + +P ++T +F ++ CN D+L I
Sbjct: 594 LTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDYLEIRDG 653
Query: 93 -TYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 151
Y++ + C + PP ++ I FHSD IS +GF + Y + S+
Sbjct: 654 PLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQGFHITYLTSPSD-------- 705
Query: 152 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ-PCAYNQFQCLSRFTKV 210
RCG PE + + G + C P Q + + QC S ++
Sbjct: 706 LRCGGNYTDPEG-ELFLPELSGPFTHTRQCVYMMKQPQGEQIQINFTHVELQCQSDSSQN 764
Query: 211 YTCLPESLKCDGNI-------------DCLDLGDEIDCDVP----------TCGQWLKYF 247
Y + + G + + + + +ID V CG L
Sbjct: 765 YIEVRDGETLLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQVACGDELT-G 823
Query: 248 YGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGY--GDYVKI 298
G SP +P+ YP C W I + ++L FT F++ + + DYV+I
Sbjct: 824 EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIGSSAHCETDYVEI 876
Score = 81.3 bits (199), Expect = 4e-15
Identities = 92/366 (25%), Positives = 142/366 (38%), Gaps = 62/366 (16%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 98
SG+ITSP +P+ Y + +CS + A G IT++F DFDI+ C D +T+ + E
Sbjct: 2697 SGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPE 2756
Query: 99 S---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 155
S + CG++ P S + + + F+SD ++ GF Y + ++ C F
Sbjct: 2757 SPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGF---YATWNTQTLGCG-GIFHSD 2812
Query: 156 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF-------QCLSRFT 208
NG W N + C+ A + + N F QC + F
Sbjct: 2813 NGTIRSPHWPQN-------FPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFV 2865
Query: 209 KVYTCLPESLKC-----DGNI------------DCLDLGDEIDCD------VPTCGQWLK 245
KV+ E K GN+ + E V CG
Sbjct: 2866 KVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQGFSASFVSRCGSNFT 2925
Query: 246 YFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD------GTGYGDYVKIY 299
G SPNYP Y NCT++I+ V+L F F L+ G+ D V I
Sbjct: 2926 GPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCVNDGVHII 2985
Query: 300 DGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPW 359
G V + APLT+ +G + ++F +++ GF +Y++
Sbjct: 2986 RGYSVMSTPFATV-CGDEMPAPLTI---AGPVLLNFYSNEQITDFGFKFSYRI------- 3034
Query: 360 EIPCGG 365
I CGG
Sbjct: 3035 -ISCGG 3039
Score = 74.7 bits (182), Expect = 3e-13
Identities = 42/131 (32%), Positives = 65/131 (49%), Gaps = 4/131 (3%)
Query: 8 KESPRWRSALLLLFLAGVYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGE 67
K S + F A ACGE + +G I SPG P+ YP INC+W I P
Sbjct: 912 KSSSTENHGFMAKFSAEDLACGEI---LTESTGTIQSPGHPNVYPHGINCTWHILVQPNH 968
Query: 68 IITISFQDFDIQGSRRCNLDWLTI-ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDD 126
+I + F+ F ++ C D+L + +T R CG +IPP SS + + + F +D
Sbjct: 969 LIHLMFETFHLEFHYNCTNDYLEVYDTDSETSLGRYCGKSIPPSLTSSGNSLMLVFVTDS 1028
Query: 127 NISRKGFRLAY 137
+++ +GF + Y
Sbjct: 1029 DLAYEGFLINY 1039
Score = 71.2 bits (173), Expect = 4e-12
Identities = 42/119 (35%), Positives = 62/119 (52%), Gaps = 8/119 (6%)
Query: 23 AGVYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSR 82
A V ACG T GI SPG+P YP + C W I ++PG + +SF F ++ S+
Sbjct: 1733 ASVSACGGT---FYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDSQ 1789
Query: 83 RCNLDWLTIETYKNIESY---RACGSTIPPPYISSQDH-IWIRFHSDDNISRKGFRLAY 137
C+ D++ I N + R CG++ P Y S H +W+RF SD + S GF+ +
Sbjct: 1790 DCSRDFVEIRE-GNATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATF 1847
Score = 70.5 bits (171), Expect = 6e-12
Identities = 41/119 (34%), Positives = 63/119 (52%), Gaps = 9/119 (7%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 84
VY CG ++ +G +SPG+P+ YP C W+IR +PG I ++ DFD++ RC
Sbjct: 1388 VYGCGG---ELSGATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEYHSRC 1444
Query: 85 NLDWLTIETYKNIESYR---ACGSTIP--PPYISSQ-DHIWIRFHSDDNISRKGFRLAY 137
N D L I + S R C P P +SS + + IRF +D +I+ +GF ++
Sbjct: 1445 NFDVLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASW 1503
Score = 68.9 bits (167), Expect = 2e-11
Identities = 40/122 (32%), Positives = 65/122 (53%), Gaps = 5/122 (4%)
Query: 26 YACGETPEQIRAPSGIITSPGWPS-EYPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 84
Y+ + ++ SG++ S G P+ Y + C W ++ G +TISF+DF++Q S C
Sbjct: 2331 YSIAQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQNSSGC 2390
Query: 85 NLDWLTI---ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 141
D++ I T NI R CG+TIP +S + +RF +D +++ GFRL + S
Sbjct: 2391 EKDFVEIWDNHTSGNILG-RYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFESSM 2449
Query: 142 SE 143
E
Sbjct: 2450 EE 2451
Score = 67.4 bits (163), Expect = 5e-11
Identities = 82/357 (22%), Positives = 141/357 (39%), Gaps = 52/357 (14%)
Query: 39 SGIITSPGWP-SEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNI 97
SGIITSP + ++YP ++C + I + ++I + F DFD+ S C+ D+L I N
Sbjct: 3045 SGIITSPAYSYADYPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLAIYDGANT 3104
Query: 98 ES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRC 154
+ CGS PP SS + + + F +D + KG+++++ ++ P C +
Sbjct: 3105 SDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSF--RQTLGPQQGCGGYLT 3162
Query: 155 GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ----PCAYNQFQCLSRFTKV 210
G+ +N + + I N F A + +CL + K+
Sbjct: 3163 GSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCLYDYVKL 3222
Query: 211 YTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFY---------------------- 248
Y E+ G G + + G +L +
Sbjct: 3223 YDGDSENANLAGTF----CGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTIMDMPC 3278
Query: 249 -GTFN---------SPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYG---DY 295
GT+N SPN D P S CTW+ID+ H++V + T + L T +Y
Sbjct: 3279 GGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSPPHQQV--KITVWALQLTSQDCTQNY 3336
Query: 296 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQV 352
+++ D + + + + S P+ SS V F + VN + TYQ+
Sbjct: 3337 LQLQDSPQGHGNSRFQFCGRNASAVPV-FYSSMSTAMVIFKSGVVNRNSRMSFTYQI 3392
Score = 67.0 bits (162), Expect = 7e-11
Identities = 80/346 (23%), Positives = 132/346 (38%), Gaps = 40/346 (11%)
Query: 38 PSGIITSPGWPS--EYPAKINCSWFIRANPGE---IITISFQDFDIQGSRRCNLDWLTIE 92
P G TSPG+ Y +NC W + +NP + I+I F+DF ++ + C D L
Sbjct: 2578 PEGNFTSPGYDGVRNYSRNLNCEWTL-SNPNQGNSSISIHFEDFYLESHQDCQFDVLEFR 2636
Query: 93 T--YKNIESYRACGSTIPP-PYISSQDHIWIRFHSDDNISRKGFRLAYF----------- 138
+R CG + P P + +WI F +++ + GF Y
Sbjct: 2637 VGDADGPLMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYSFTDCGGIQIGD 2696
Query: 139 SGKSEEPNC--ACDQF-RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEA-------NPP 188
SG PN A D C + P+ D CA ++ +P
Sbjct: 2697 SGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPE 2756
Query: 189 TAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFY 248
+ Q C + + + + L + D ++ + CG
Sbjct: 2757 SPIIGQYCGNSNPRTIQSGSNQ---LVVTFNSDHSLQGGGFYATWNTQTLGCGGIFHSDN 2813
Query: 249 GTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL----DGTGYGDYVKIYDGLEE 304
GT SP++P +P S C+W T + + + F + L DG +VK++ G EE
Sbjct: 2814 GTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTEE 2873
Query: 305 NPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 350
LL T + AP V++ S F + + A+GF+A++
Sbjct: 2874 VDKALL--ATGCGNVAPGPVITPSNTFTAVFQSQEA-PAQGFSASF 2916
Score = 64.7 bits (156), Expect = 3e-10
Identities = 44/132 (33%), Positives = 60/132 (45%), Gaps = 9/132 (6%)
Query: 238 PTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD--GTGYGDY 295
P CG L YG+ SP YP YPPG +C W++ T V F L+ DY
Sbjct: 588 PECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEHHDDCNKDY 647
Query: 296 VKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGF 355
++I DG L + T F S PL R+HF +D + +GF+ TY
Sbjct: 648 LEIRDGPLYQDPLLGKFCTTF-SVPPLQTTGPFA--RIHFHSDSQISDQGFHITYLTS-- 702
Query: 356 CLPWEIPCGGNW 367
P ++ CGGN+
Sbjct: 703 --PSDLRCGGNY 712
Score = 63.5 bits (153), Expect = 8e-10
Identities = 79/354 (22%), Positives = 131/354 (37%), Gaps = 59/354 (16%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI--QGSRRCNLD----WLTIE 92
+G I SP WP +P CSW + + + ISF + + G +C W E
Sbjct: 2813 NGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISFDNNFLIPSGDGQCQNSFVKVWAGTE 2872
Query: 93 TYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQF 152
CG+ P P I+ + F S + +GF ++ S
Sbjct: 2873 EVDKALLATGCGNVAPGPVITPSNTFTAVFQSQE-APAQGFSASFVS------------- 2918
Query: 153 RCGNGKCIPEAWKCN-NMDECGDSSDEEICAKEANP--------------PTAAAFQPCA 197
RCG+ P + + N + D++ EANP +A C
Sbjct: 2919 RCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAVTGSCV 2978
Query: 198 YNQFQCLSRFTKVYT-----C---LPESLKCDG--------NIDCLDLGDEIDCDVPTCG 241
+ + ++ + T C +P L G N D G + + +CG
Sbjct: 2979 NDGVHIIRGYSVMSTPFATVCGDEMPAPLTIAGPVLLNFYSNEQITDFGFKFSYRIISCG 3038
Query: 242 QWLKYFYGTFNSP--NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKL--DGTGYGDYVK 297
+ G SP +Y D YP +C + I D + + L+F+DF + + DY+
Sbjct: 3039 GVFNFSSGIITSPAYSYAD-YPNDMHCLYTITVSDDKVIELKFSDFDVVPSTSCSHDYLA 3097
Query: 298 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 351
IYDG + L + S P V SS+ + + F D A+G+ +++
Sbjct: 3098 IYDGANTSDPLLGKFC---GSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFR 3148
Score = 62.0 bits (149), Expect = 2e-09
Identities = 47/155 (30%), Positives = 63/155 (40%), Gaps = 20/155 (12%)
Query: 240 CGQWLKYFYGTFNSPNYPD--FYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYG---- 293
CG +L TF SP+ Y NC W+I ++ + L F F L+
Sbjct: 3157 CGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTRQRCL 3216
Query: 294 -DYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQV 352
DYVK+YDG EN + T S P +SS + V F +D GFNATY +
Sbjct: 3217 YDYVKLYDGDSENANL---AGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATYTI 3273
Query: 353 DGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRD 387
++PCGG + Q PN D
Sbjct: 3274 ------MDMPCGGTYNATWTPQNISS----PNSSD 3298
Score = 61.6 bits (148), Expect = 3e-09
Identities = 37/125 (29%), Positives = 60/125 (48%), Gaps = 7/125 (5%)
Query: 19 LLFLAGVYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI 78
+++ + CG T + G TSPG+P YP C W + A G ++TI+F I
Sbjct: 3502 IIWTSSPSGCGGT---LYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISI 3558
Query: 79 QGSRRCNLDWLTIETYKNIESYRA---C-GSTIPPPYISSQDHIWIRFHSDDNISRKGFR 134
C ++LT+ N S + C G T P+++S + ++I+FH+D FR
Sbjct: 3559 DDPGDCVQNYLTLYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAFR 3618
Query: 135 LAYFS 139
L + S
Sbjct: 3619 LTWDS 3623
Score = 61.2 bits (147), Expect = 4e-09
Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 13/141 (9%)
Query: 15 SALLLLFLAGV----------YACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRAN 64
S +++F +GV Y + G + SPGWP Y +C+ + A
Sbjct: 3369 STAMVIFKSGVVNRNSRMSFTYQIADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAP 3428
Query: 65 PGEIITISFQDFDIQGSRRCNLDWLTIETYKNIES---YRACGSTIPPPYISSQDHIWIR 121
I++ F I+ S C D+L + N S + CG+ +P P S + +++R
Sbjct: 3429 QNHTISLFFHSLGIENSVECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLR 3488
Query: 122 FHSDDNISRKGFRLAYFSGKS 142
F SD S +G+ + + S S
Sbjct: 3489 FKSDSVTSDRGYEIIWTSSPS 3509
Score = 55.1 bits (131), Expect = 3e-07
Identities = 39/114 (34%), Positives = 51/114 (44%), Gaps = 5/114 (4%)
Query: 240 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD--GTGYGDYVK 297
CG L GTF SPNYP Y S C W + + L F DF L+ DY+
Sbjct: 1165 CGGNLTTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHPNCTLDYLA 1224
Query: 298 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 351
+YDG N H L ++ D PL + SS + + D+ RGF A Y+
Sbjct: 1225 VYDGPSSNSHLLTQL--CGDEKPPL-IRSSGDSMFIKLRTDEGQQGRGFKAEYR 1275
Score = 53.9 bits (128), Expect = 6e-07
Identities = 33/120 (27%), Positives = 59/120 (49%), Gaps = 11/120 (9%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQG---- 80
V CG PSG I SP +P +Y +NC++ I ANP ++ ++F F ++
Sbjct: 2917 VSRCGSN---FTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLEARSAV 2973
Query: 81 SRRCNLDWLTIETYKNIES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAY 137
+ C D + I ++ S CG +P P ++ + + F+S++ I+ GF+ +Y
Sbjct: 2974 TGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAP-LTIAGPVLLNFYSNEQITDFGFKFSY 3032
Score = 53.5 bits (127), Expect = 8e-07
Identities = 43/161 (26%), Positives = 63/161 (39%), Gaps = 30/161 (18%)
Query: 239 TCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTD-FKL----DGTGYG 293
+CG +L G SP YP+ YP NC+W + + + F F++ G
Sbjct: 2091 SCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHFEQPFQIPNGDSSCNQG 2150
Query: 294 DYVKIYDGLE----------ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAA 343
DY+ + +G + N H SHA T+ +S Q+ V F +D N
Sbjct: 2151 DYLVLRNGPDICSPPLGPPGGNGH-------FCGSHASSTLFTSDNQMFVQFISDHSNEG 2203
Query: 344 RGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPN 384
+GF Y+ + CGGN Y GY PN
Sbjct: 2204 QGFKIKYEAK------SLACGGN--VYIHDADSAGYVTSPN 2236
Score = 53.1 bits (126), Expect = 1e-06
Identities = 32/110 (29%), Positives = 50/110 (45%), Gaps = 4/110 (3%)
Query: 33 EQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIE 92
+ I G + SP WP YP N W + N ++ + DI+ + C D L I
Sbjct: 1854 DNIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIY 1913
Query: 93 TYKNIESY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFS 139
+I + CG T + S+ + + F+SD +IS KGF L +F+
Sbjct: 1914 DGPSIHARLIGAYCG-TQTESFSSTGNSLTFHFYSDSSISGKGFLLEWFA 1962
Score = 49.3 bits (116), Expect = 1e-05
Identities = 45/178 (25%), Positives = 74/178 (41%), Gaps = 22/178 (12%)
Query: 196 CAYNQFQCLSRFTKVYTCLPESLKCDG----NIDCLDLGDEIDCDVP--TCGQWLKYFYG 249
C N +CLS CL DG + +C L C VP CG+ L G
Sbjct: 429 CTENINECLSN-----PCLNGGTCVDGVDSFSCECTRLWTGALCQVPQQVCGESLSGING 483
Query: 250 TFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGY--GDYVKIYDGLEENPH 307
+F+ + Y NC W+I T + + + FT F+L+ +++++YDG +
Sbjct: 484 SFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNCPHEFLQVYDGDSSSAF 543
Query: 308 KLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 365
+L R S P ++SS + H ++ + RGF ++ + CGG
Sbjct: 544 QLGRFC---GSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRWETQ------QPECGG 592
Score = 49.3 bits (116), Expect = 1e-05
Identities = 30/126 (23%), Positives = 65/126 (51%), Gaps = 11/126 (8%)
Query: 30 ETPEQI--RAPSGIITSPGWPSE---YPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 84
+ P+Q+ + SGI S + S Y +NC W I+ G+++ I+F F ++ C
Sbjct: 468 QVPQQVCGESLSGINGSFSYRSPDVGYVHDVNCFWVIKTEMGKVLRITFTFFRLESMDNC 527
Query: 85 NLDWLTI---ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 141
++L + ++ + R CGS++P +SS + ++ +S+ + +GF + + +
Sbjct: 528 PHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRW---E 584
Query: 142 SEEPNC 147
+++P C
Sbjct: 585 TQQPEC 590
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/113 (30%), Positives = 48/113 (42%), Gaps = 4/113 (3%)
Query: 240 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTG--YGDYVK 297
CG L G+F SP YP YP + C W++ R V + F +D G +Y+
Sbjct: 3511 CGGTLYGDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISIDDPGDCVQNYLT 3570
Query: 298 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 350
+YDG + S AP V+SS Q+ + F AD F T+
Sbjct: 3571 LYDGPNASSPSSGPYCGGDTSIAPF--VASSNQVFIKFHADYARRPSAFRLTW 3621
Score = 46.2 bits (108), Expect = 1e-04
Identities = 58/246 (23%), Positives = 97/246 (39%), Gaps = 60/246 (24%)
Query: 249 GTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD--GTGYGDYVKIYD-GLEEN 305
G SPNYP+ Y ++C+ L++ + L F+DF ++ T D V + + G E+
Sbjct: 2698 GVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIEPHTTCAWDSVTVRNGGSPES 2757
Query: 306 PHKLLRVLTAFDSHA-PLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCG 364
P ++ + ++ P T+ S S Q+ V F +D GF AT+
Sbjct: 2758 P-----IIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGFYATWN------------- 2799
Query: 365 GNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNY------QN 418
T+ C G +H NG + +P + +P + RC++
Sbjct: 2800 ------TQTLGCGGIFHSDNG-------TIRSPHWPQN-----FPENSRCSWTAITHKSK 2841
Query: 419 HCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDD-------CGDGSDEENCPVIVP 471
H D N F G+ C+N+ + W + D CG+ + PVI P
Sbjct: 2842 HLEISFD--NNFLIPSGDGQCQNS--FVKVWAGTEEVDKALLATGCGNVAPG---PVITP 2894
Query: 472 TRVITA 477
+ TA
Sbjct: 2895 SNTFTA 2900
Score = 38.9 bits (89), Expect = 0.020
Identities = 26/101 (25%), Positives = 45/101 (44%), Gaps = 6/101 (5%)
Query: 248 YGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLD--GTGYGDYVKIYDGLEEN 305
+G SP +P+ YP SN W ++ V R + ++ Y D ++IYDG
Sbjct: 1860 HGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQNCYYDKLRIYDG---- 1915
Query: 306 PHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGF 346
P R++ A+ + S+ + HF +D + +GF
Sbjct: 1916 PSIHARLIGAYCGTQTESFSSTGNSLTFHFYSDSSISGKGF 1956
Score = 37.7 bits (86), Expect = 0.045
Identities = 36/139 (25%), Positives = 58/139 (41%), Gaps = 13/139 (9%)
Query: 15 SALLLLFLAGVYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQ 74
S L F + + CG ++ G TSP +P+ P C W I A G IT+ F
Sbjct: 2439 SGFRLRFESSMEECGG---DLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFN 2495
Query: 75 DFDIQGSRRCNLDWLTIETYKNIES-----YRACGS-TIPPPYISSQDHIWIRFHSDDNI 128
+ + CN + + + + I S + C S + SS + + + F +D +
Sbjct: 2496 NLRLATHPSCNNEHVIV--FNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSR 2553
Query: 129 SRKGFRLAYFSGKSEEPNC 147
GF +Y S SE+ C
Sbjct: 2554 PYGGFTASYTS--SEDAVC 2570
Score = 35.0 bits (79), Expect = 0.29
Identities = 23/112 (20%), Positives = 47/112 (41%), Gaps = 5/112 (4%)
Query: 237 VPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGT--GYGD 294
+ C + +G SP +PD Y +CT + + + L F ++ + D
Sbjct: 3392 IADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSVECRND 3451
Query: 295 YVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGF 346
++++ +G N L + P V S + ++ + F +D V + RG+
Sbjct: 3452 FLEVRNGSNSNSPLLGKYCGTL---LPNPVFSQNNELYLRFKSDSVTSDRGY 3500
>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo
sapiens]
Length = 3667
Score = 93.6 bits (231), Expect = 7e-19
Identities = 86/340 (25%), Positives = 140/340 (41%), Gaps = 64/340 (18%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRA-NPGEIITISFQDFDIQGSRR 83
V CG ++ PSG TSP +P +Y + C W I A N ++I I+F++FD++
Sbjct: 505 VKTCGSN---LQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE---- 557
Query: 84 CNLDWLTIETYKNIESYRA-----CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYF 138
D LTI + R GS +P +S +W+ +D+++ GF++ Y
Sbjct: 558 IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY- 616
Query: 139 SGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 198
K + CGD +E + F
Sbjct: 617 --------------------------KEIEKESCGDPGTPLYGIREGD-----GFSNRDV 645
Query: 199 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC-GQWLKYF---YGTFNSP 254
+F+C F + +S+ C N ++ ++P C L F GT SP
Sbjct: 646 LRFECQFGFELIG---EKSIVCQEN-------NQWSANIPICIFPCLSNFTAPMGTVLSP 695
Query: 255 NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 314
+YP+ Y NC W I + ++ L F DF L+ D++ + DG ++P + + T
Sbjct: 696 DYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE--SQFDFLAVKDG--DSPESPI-LGT 750
Query: 315 AFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 354
+ P + S+S +R+ F AD + RGFN TY G
Sbjct: 751 FTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFG 790
Score = 91.3 bits (225), Expect = 3e-18
Identities = 84/334 (25%), Positives = 141/334 (42%), Gaps = 59/334 (17%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 84
+Y CG T ++ +G I SPG+P YP NC+W I A I I FQ F ++
Sbjct: 22 IYTCGGT---LKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE---- 74
Query: 85 NLDWLTI-ETYKNIESYRA--CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 141
D+L++ + + + ++R G +PPP S++ +R SD +S GF++ Y +
Sbjct: 75 EYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQ 134
Query: 142 SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 201
S CGN P+ + GD ++
Sbjct: 135 SSS---------CGNPGVPPKGVLYGTRFDVGDKI-----------------------RY 162
Query: 202 QCLSRFT----KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYP 257
C++ + TC+ S+ N D I CG ++ G +SP++P
Sbjct: 163 SCVTGYILDGHPQLTCIANSV----NTASWDFPVPICRAEDACGGTMRGSSGIISSPSFP 218
Query: 258 DFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD 317
+ Y ++CTW I + L FTDF+++ DY++I +G E +
Sbjct: 219 NEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK--YDYLEI-EGSEP------PTIWLSG 269
Query: 318 SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 351
+ P ++S+ +R+HF D + RGF+A YQ
Sbjct: 270 MNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303
Score = 80.9 bits (198), Expect = 5e-15
Identities = 81/322 (25%), Positives = 135/322 (41%), Gaps = 54/322 (16%)
Query: 37 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 96
AP G + SP +P Y +NC W I ++PG I +SF DFD++ D+L ++ +
Sbjct: 687 APMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKDGDS 742
Query: 97 IES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 153
ES G+ +P S+ + + F +D ++S +GF + Y +
Sbjct: 743 PESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT-------------- 788
Query: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 213
G+ +C P+ N GD+ FQ + C F K T
Sbjct: 789 FGHNEC-PDPGIPINARRFGDN-----------------FQLGSSISVICEEGFIK--TQ 828
Query: 214 LPESLKC---DGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLI 270
E++ C DG + L + C P CG G SP +P +Y NC W+I
Sbjct: 829 GTETITCILMDGKVMWSGLIPK--CGAP-CGGHFSAPSGVILSPGWPGYYKDSLNCEWVI 885
Query: 271 DTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD-SHAPLTVVSSSG 329
+ + + F F+ + Y D ++++DG P+ L +L +++ + P + SSS
Sbjct: 886 EAEPGHSIKITFERFQTE-LNY-DVLEVHDG----PNLLSPLLGSYNGTQVPQFLFSSSN 939
Query: 330 QIRVHFCADKVNAARGFNATYQ 351
I + F D + GF Y+
Sbjct: 940 FIYLLFTTDNSRSNNGFKIHYE 961
Score = 80.5 bits (197), Expect = 6e-15
Identities = 82/325 (25%), Positives = 128/325 (39%), Gaps = 65/325 (20%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 98
SG I SPG+P Y + C W I +PG I+++ F FD + S W ++
Sbjct: 1383 SGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW-DGPPENDML 1441
Query: 99 SYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKS---EEPNCACDQFRCG 155
GS IP S+ + + I+F +D IS+ GF + + S + +P + R G
Sbjct: 1442 LKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNG 1501
Query: 156 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 215
+G+ E GD T V+ C P
Sbjct: 1502 DGR------------EPGD---------------------------------TVVFQCDP 1516
Query: 216 -ESLKCDGNIDCLDLGDEI-------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCT 267
L+ + I C+ + + C P CG L G SPN+P YP +C
Sbjct: 1517 GYELQGEERITCIQVENRYFWQPSPPVCIAP-CGGNLTGSSGFILSPNFPHPYPHSRDCD 1575
Query: 268 WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVS 326
W I + L F F ++ D++ IYDG + N ++ +F DS P + S
Sbjct: 1576 WTITVNADYVISLAFISFSIEPN--YDFLYIYDGPDSNS----PLIGSFQDSKLPERIES 1629
Query: 327 SSGQIRVHFCADKVNAARGFNATYQ 351
SS + + F +D + GF+ Y+
Sbjct: 1630 SSNTMHLAFRSDGSVSYTGFHLEYK 1654
Score = 72.8 bits (177), Expect = 1e-12
Identities = 82/327 (25%), Positives = 121/327 (37%), Gaps = 62/327 (18%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 94
+R PSG I SPG+P YP +NC+W + G+ + +F F ++ D+L I
Sbjct: 1031 VRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHH----DYLLITEN 1086
Query: 95 KNIES--YRACGSTIPPPY---ISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 149
+ R GS +PP + +RF SD +IS +GF + +
Sbjct: 1087 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE---------- 1136
Query: 150 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 209
N++ C D + ++ F F C S +
Sbjct: 1137 -----------------YNLEPCEDPGIPQYGSR-----IGFNFGIGDTLTFSCSSGY-- 1172
Query: 210 VYTCLPESLKCDGNIDCLDLGDEI------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 263
L+ I CL G + C V CG G SPNYP Y
Sbjct: 1173 -------RLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPNYPLNYENN 1224
Query: 264 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 323
C + I + + + F L GD +KIYDG ++ H LL T S LT
Sbjct: 1225 HECIYSIQVQAGKGINISARTFHL---AQGDVLKIYDGKDKTTH-LLGAFTG-ASMRGLT 1279
Query: 324 VVSSSGQIRVHFCADKVNAARGFNATY 350
+ S+S Q+ + F +D GF Y
Sbjct: 1280 LSSTSNQLWLEFNSDTEGTDEGFQLVY 1306
Score = 72.0 bits (175), Expect = 2e-12
Identities = 62/256 (24%), Positives = 99/256 (38%), Gaps = 69/256 (26%)
Query: 37 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 96
APSG+I SPGWP Y +NC W I A PG I I+F+ F + N D L + N
Sbjct: 861 APSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPN 916
Query: 97 -----IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNC---- 147
+ SY G+ +P SS + I++ F +D++ S GF++ Y S +C
Sbjct: 917 LLSPLLGSYN--GTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPG 974
Query: 148 ---------------ACDQFRCGNG---------KCIPEAWKCNNMDECGDSSDEEICAK 183
+ F C +G C W + + C + +C
Sbjct: 975 IPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-----DALCGG 1029
Query: 184 EANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQW 243
+ P+ P Y +F P SL C +D T G+
Sbjct: 1030 DVRGPSGTILSP-GYPEF------------YPNSLNCTWTVDV------------THGKG 1064
Query: 244 LKYFYGTFNSPNYPDF 259
+++ + TF+ ++ D+
Sbjct: 1065 VQFNFHTFHLEDHHDY 1080
Score = 71.2 bits (173), Expect = 4e-12
Identities = 68/304 (22%), Positives = 121/304 (39%), Gaps = 50/304 (16%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 98
SG+I SPG+P YP+ ++C+W I G + + F +F + D+L + + +
Sbjct: 2079 SGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH----DYLEVRSGSSET 2134
Query: 99 SY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 155
S R G IP S+ + FHSD + +++GF + Y + + + C
Sbjct: 2135 STVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS---------CP 2185
Query: 156 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 215
+ + + N G + F+C +T +
Sbjct: 2186 DPRPFRNGFVIGNDFTVGQTI-----------------------SFECFPGYTLIGN--- 2219
Query: 216 ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDH 275
+L C + + + CG + GT SP YPD YP +C WL+
Sbjct: 2220 SALTCLHGVS-RNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPG 2278
Query: 276 RKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL-TVVSSSGQIRVH 334
+ + FT L D++ ++DG ++N + + F + L +V S+S QI +
Sbjct: 2279 NGIYINFT--VLQTEPIYDFITVWDGPDQNSPQ----IGQFSGNTALESVYSTSNQILIK 2332
Query: 335 FCAD 338
F +D
Sbjct: 2333 FHSD 2336
Score = 70.1 bits (170), Expect = 8e-12
Identities = 85/318 (26%), Positives = 123/318 (38%), Gaps = 50/318 (15%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN-- 96
SG I SP +P YP +C W I N +I+++F F I+ N D+L I +
Sbjct: 1556 SGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEP----NYDFLYIYDGPDSN 1611
Query: 97 ---IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 153
I S++ S +P SS + + + F SD ++S GF L Y K++ D
Sbjct: 1612 SPLIGSFQ--DSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY---KAKLRESCFDPGN 1666
Query: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 213
NG + +K + T + Y + + TC
Sbjct: 1667 IMNGTRLGMDYKLGS--------------------TVTYYCDAGY-----VLQGYSTLTC 1701
Query: 214 LPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTG 273
+ G L C P CG GT SPNYP Y G NC + I
Sbjct: 1702 IMGDDGRPGWNRALP-----SCHAP-CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVP 1755
Query: 274 DHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRV 333
V +F F+ T D V++YDG + LL L+ S L +SS QI +
Sbjct: 1756 KEFVVFGQFVFFQ---TSLHDVVEVYDGPTQQ-SSLLSSLSGSHSGESLP-LSSGNQITI 1810
Query: 334 HFCADKVNAARGFNATYQ 351
F + A+GF+ YQ
Sbjct: 1811 RFTSVGPITAKGFHFVYQ 1828
Score = 67.8 bits (164), Expect = 4e-11
Identities = 74/323 (22%), Positives = 125/323 (38%), Gaps = 64/323 (19%)
Query: 40 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY----- 94
G I SPG+P Y +NC W I G I + F + +W +++ Y
Sbjct: 1908 GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH------NWDSLDFYDGGDN 1961
Query: 95 --KNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQF 152
+ SY G+TIP S+ +++++ F SD ++S GF L Y +
Sbjct: 1962 NAPRLGSY--SGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTA------------- 2006
Query: 153 RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT---- 208
G C PE ++ + GD + FQC ++
Sbjct: 2007 -IGLDSC-PEPQTPSSGIKIGD-----------------RYMVGDVVSFQCDQGYSLQGH 2047
Query: 209 KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTW 268
TC+P ++ I + CG + F G SP +P YP +CTW
Sbjct: 2048 SHITCMPGPVR--------RWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTW 2099
Query: 269 LIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSS 328
I+ V L+F +F + DY+++ G E + R+ P ++ S++
Sbjct: 2100 TINLPIGFGVHLQFVNFSTE--TIHDYLEVRSGSSETSTVIGRL---SGPQIPSSLFSTT 2154
Query: 329 GQIRVHFCADKVNAARGFNATYQ 351
+ ++F +D +GF+ YQ
Sbjct: 2155 HETSLYFHSDYSQNKQGFHIVYQ 2177
Score = 66.6 bits (161), Expect = 9e-11
Identities = 46/119 (38%), Positives = 64/119 (53%), Gaps = 6/119 (5%)
Query: 235 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVI-LRFTDFKLDGTGYG 293
C V TCG L+ GTF SPN+P Y + C W+I + KVI + F +F L+ GY
Sbjct: 503 CKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE-IGY- 560
Query: 294 DYVKIYDGLE-ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 351
D + I DG E +P +L+VLT S P +VS S Q+ +H D+ + GF Y+
Sbjct: 561 DTLTIGDGGEVGDPRTVLQVLTG--SFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYK 617
Score = 65.9 bits (159), Expect = 2e-10
Identities = 85/342 (24%), Positives = 132/342 (38%), Gaps = 61/342 (17%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 91
I A +G I SPG+P EYP +C W +R PG I I+F + D++T+
Sbjct: 2247 ITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----YDFITVWDG 2302
Query: 92 ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 151
+ + + G+T S+ + I I+FHSD S F L+Y + +
Sbjct: 2303 PDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQLRV------- 2354
Query: 152 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT--- 208
C +P A DE F+ ++QCL FT
Sbjct: 2355 --CQPPPPVPNAEILTEDDE---------------------FEIGDIIRYQCLPGFTLVG 2391
Query: 209 -KVYTC-LPESLKCDGN---IDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 263
+ TC L E L+ DG L +E+ D G SP YPD YP
Sbjct: 2392 NAILTCRLGERLQMDGAPPVCQVLCPANELRLDST----------GVILSPGYPDSYPNL 2441
Query: 264 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 323
C W I + + F +F + D +++YDG N + + + D +
Sbjct: 2442 QMCAWSISVEKGYNITM-FVEFFQTEKEF-DVLQVYDG--PNIQSPVLISLSGDYSSAFN 2497
Query: 324 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 365
+ S+ ++ + + AD N +GF Y + +C E P G
Sbjct: 2498 ITSNGHEVFLQWSADHGNNKKGFRIRY-IAFYCSTPESPPHG 2538
Score = 48.1 bits (113), Expect = 3e-05
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 10/119 (8%)
Query: 235 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 294
CD CG ++ GT SP YP+FYP NCTW +D + V F F L+ + D
Sbjct: 1023 CDA-LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLE--DHHD 1079
Query: 295 YVKIYDGLEENPHKLLRVLTAFDSHAPLTV---VSSSGQIRVHFCADKVNAARGFNATY 350
Y+ I EN + S P T+ + + + ++ F +D + GFN T+
Sbjct: 1080 YLLI----TENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1134
Score = 46.2 bits (108), Expect = 1e-04
Identities = 74/320 (23%), Positives = 124/320 (38%), Gaps = 66/320 (20%)
Query: 40 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI-QGSRRCNLDWLTIETYKNIE 98
GI+ SP +P Y C + I+ G+ I IS + F + QG D L I K+
Sbjct: 1210 GILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG------DVLKIYDGKDKT 1263
Query: 99 SY---RACGSTIPPPYISS-QDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRC 154
++ G+++ +SS + +W+ F+SD + +GF+L Y S +
Sbjct: 1264 THLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFE------------- 1310
Query: 155 GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCL 214
+ C D + K ++ A T +Y C
Sbjct: 1311 --------------LSHCEDPGIPQFGYKISDQGHFAG--------------STIIYGCN 1342
Query: 215 P-ESLKCDGNIDCLDLGDE--IDCDVPTC-----GQWLKYFYGTFNSPNYPDFYPPGSNC 266
P +L + C+ G+ D +P+C G++ G SP YP Y C
Sbjct: 1343 PGYTLHGSSLLKCM-TGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRC 1401
Query: 267 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 326
W+I+ V L+F F D D ++++DG EN LL+ ++ S P + S
Sbjct: 1402 MWMIEVDPGNIVSLQFLAF--DTEASHDILRVWDGPPEN-DMLLKEISG--SLIPEGIHS 1456
Query: 327 SSGQIRVHFCADKVNAARGF 346
+ + + F D + GF
Sbjct: 1457 TLNIVTIQFDTDFYISKSGF 1476
Score = 43.5 bits (101), Expect = 8e-04
Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 8/133 (6%)
Query: 235 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 294
C VP CG L GT SP YP+ Y NC W I + + ++ F + D
Sbjct: 1895 CIVP-CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN--WD 1951
Query: 295 YVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 354
+ YDG + N R+ + + P + S+S + ++F +D +A GF+ Y G
Sbjct: 1952 SLDFYDGGDNNAP---RLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2008
Query: 355 F--CLPWEIPCGG 365
C + P G
Sbjct: 2009 LDSCPEPQTPSSG 2021
>gi|38045888 CUB and Sushi multiple domains 3 isoform 1 [Homo
sapiens]
Length = 3707
Score = 93.6 bits (231), Expect = 7e-19
Identities = 86/340 (25%), Positives = 140/340 (41%), Gaps = 64/340 (18%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRA-NPGEIITISFQDFDIQGSRR 83
V CG ++ PSG TSP +P +Y + C W I A N ++I I+F++FD++
Sbjct: 545 VKTCGSN---LQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE---- 597
Query: 84 CNLDWLTIETYKNIESYRA-----CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYF 138
D LTI + R GS +P +S +W+ +D+++ GF++ Y
Sbjct: 598 IGYDTLTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNY- 656
Query: 139 SGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 198
K + CGD +E + F
Sbjct: 657 --------------------------KEIEKESCGDPGTPLYGIREGD-----GFSNRDV 685
Query: 199 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC-GQWLKYF---YGTFNSP 254
+F+C F + +S+ C N ++ ++P C L F GT SP
Sbjct: 686 LRFECQFGFELIG---EKSIVCQEN-------NQWSANIPICIFPCLSNFTAPMGTVLSP 735
Query: 255 NYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 314
+YP+ Y NC W I + ++ L F DF L+ D++ + DG ++P + + T
Sbjct: 736 DYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE--SQFDFLAVKDG--DSPESPI-LGT 790
Query: 315 AFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 354
+ P + S+S +R+ F AD + RGFN TY G
Sbjct: 791 FTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFG 830
Score = 91.3 bits (225), Expect = 3e-18
Identities = 84/334 (25%), Positives = 141/334 (42%), Gaps = 59/334 (17%)
Query: 25 VYACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRC 84
+Y CG T ++ +G I SPG+P YP NC+W I A I I FQ F ++
Sbjct: 62 IYTCGGT---LKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEE---- 114
Query: 85 NLDWLTI-ETYKNIESYRA--CGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGK 141
D+L++ + + + ++R G +PPP S++ +R SD +S GF++ Y +
Sbjct: 115 EYDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQ 174
Query: 142 SEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQF 201
S CGN P+ + GD ++
Sbjct: 175 SSS---------CGNPGVPPKGVLYGTRFDVGDKI-----------------------RY 202
Query: 202 QCLSRFT----KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYP 257
C++ + TC+ S+ N D I CG ++ G +SP++P
Sbjct: 203 SCVTGYILDGHPQLTCIANSV----NTASWDFPVPICRAEDACGGTMRGSSGIISSPSFP 258
Query: 258 DFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD 317
+ Y ++CTW I + L FTDF+++ DY++I +G E +
Sbjct: 259 NEYHNNADCTWTIVAEPGDTISLIFTDFQMEEK--YDYLEI-EGSEP------PTIWLSG 309
Query: 318 SHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 351
+ P ++S+ +R+HF D + RGF+A YQ
Sbjct: 310 MNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 343
Score = 80.9 bits (198), Expect = 5e-15
Identities = 81/322 (25%), Positives = 135/322 (41%), Gaps = 54/322 (16%)
Query: 37 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 96
AP G + SP +P Y +NC W I ++PG I +SF DFD++ D+L ++ +
Sbjct: 727 APMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLES----QFDFLAVKDGDS 782
Query: 97 IES---YRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 153
ES G+ +P S+ + + F +D ++S +GF + Y +
Sbjct: 783 PESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNT-------------- 828
Query: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 213
G+ +C P+ N GD+ FQ + C F K T
Sbjct: 829 FGHNEC-PDPGIPINARRFGDN-----------------FQLGSSISVICEEGFIK--TQ 868
Query: 214 LPESLKC---DGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLI 270
E++ C DG + L + C P CG G SP +P +Y NC W+I
Sbjct: 869 GTETITCILMDGKVMWSGLIPK--CGAP-CGGHFSAPSGVILSPGWPGYYKDSLNCEWVI 925
Query: 271 DTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFD-SHAPLTVVSSSG 329
+ + + F F+ + Y D ++++DG P+ L +L +++ + P + SSS
Sbjct: 926 EAEPGHSIKITFERFQTE-LNY-DVLEVHDG----PNLLSPLLGSYNGTQVPQFLFSSSN 979
Query: 330 QIRVHFCADKVNAARGFNATYQ 351
I + F D + GF Y+
Sbjct: 980 FIYLLFTTDNSRSNNGFKIHYE 1001
Score = 80.5 bits (197), Expect = 6e-15
Identities = 82/325 (25%), Positives = 128/325 (39%), Gaps = 65/325 (20%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 98
SG I SPG+P Y + C W I +PG I+++ F FD + S W ++
Sbjct: 1423 SGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTEASHDILRVW-DGPPENDML 1481
Query: 99 SYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKS---EEPNCACDQFRCG 155
GS IP S+ + + I+F +D IS+ GF + + S + +P + R G
Sbjct: 1482 LKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATACRDPGVPMNGTRNG 1541
Query: 156 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 215
+G+ E GD T V+ C P
Sbjct: 1542 DGR------------EPGD---------------------------------TVVFQCDP 1556
Query: 216 -ESLKCDGNIDCLDLGDEI-------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCT 267
L+ + I C+ + + C P CG L G SPN+P YP +C
Sbjct: 1557 GYELQGEERITCIQVENRYFWQPSPPVCIAP-CGGNLTGSSGFILSPNFPHPYPHSRDCD 1615
Query: 268 WLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAF-DSHAPLTVVS 326
W I + L F F ++ D++ IYDG + N ++ +F DS P + S
Sbjct: 1616 WTITVNADYVISLAFISFSIEPN--YDFLYIYDGPDSNS----PLIGSFQDSKLPERIES 1669
Query: 327 SSGQIRVHFCADKVNAARGFNATYQ 351
SS + + F +D + GF+ Y+
Sbjct: 1670 SSNTMHLAFRSDGSVSYTGFHLEYK 1694
Score = 72.8 bits (177), Expect = 1e-12
Identities = 82/327 (25%), Positives = 121/327 (37%), Gaps = 62/327 (18%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY 94
+R PSG I SPG+P YP +NC+W + G+ + +F F ++ D+L I
Sbjct: 1071 VRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLEDHH----DYLLITEN 1126
Query: 95 KNIES--YRACGSTIPPPY---ISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCAC 149
+ R GS +PP + +RF SD +IS +GF + +
Sbjct: 1127 GSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE---------- 1176
Query: 150 DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTK 209
N++ C D + ++ F F C S +
Sbjct: 1177 -----------------YNLEPCEDPGIPQYGSR-----IGFNFGIGDTLTFSCSSGY-- 1212
Query: 210 VYTCLPESLKCDGNIDCLDLGDEI------DCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 263
L+ I CL G + C V CG G SPNYP Y
Sbjct: 1213 -------RLEGTSEIICLGGGRRVWSAPLPRC-VAECGASATNNEGILLSPNYPLNYENN 1264
Query: 264 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 323
C + I + + + F L GD +KIYDG ++ H LL T S LT
Sbjct: 1265 HECIYSIQVQAGKGINISARTFHL---AQGDVLKIYDGKDKTTH-LLGAFTG-ASMRGLT 1319
Query: 324 VVSSSGQIRVHFCADKVNAARGFNATY 350
+ S+S Q+ + F +D GF Y
Sbjct: 1320 LSSTSNQLWLEFNSDTEGTDEGFQLVY 1346
Score = 72.0 bits (175), Expect = 2e-12
Identities = 62/256 (24%), Positives = 99/256 (38%), Gaps = 69/256 (26%)
Query: 37 APSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN 96
APSG+I SPGWP Y +NC W I A PG I I+F+ F + N D L + N
Sbjct: 901 APSGVILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----LNYDVLEVHDGPN 956
Query: 97 -----IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNC---- 147
+ SY G+ +P SS + I++ F +D++ S GF++ Y S +C
Sbjct: 957 LLSPLLGSYN--GTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNTYSCLDPG 1014
Query: 148 ---------------ACDQFRCGNG---------KCIPEAWKCNNMDECGDSSDEEICAK 183
+ F C +G C W + + C + +C
Sbjct: 1015 IPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTC-----DALCGG 1069
Query: 184 EANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQW 243
+ P+ P Y +F P SL C +D T G+
Sbjct: 1070 DVRGPSGTILSP-GYPEF------------YPNSLNCTWTVDV------------THGKG 1104
Query: 244 LKYFYGTFNSPNYPDF 259
+++ + TF+ ++ D+
Sbjct: 1105 VQFNFHTFHLEDHHDY 1120
Score = 71.2 bits (173), Expect = 4e-12
Identities = 68/304 (22%), Positives = 121/304 (39%), Gaps = 50/304 (16%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIE 98
SG+I SPG+P YP+ ++C+W I G + + F +F + D+L + + +
Sbjct: 2119 SGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTETIH----DYLEVRSGSSET 2174
Query: 99 SY---RACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 155
S R G IP S+ + FHSD + +++GF + Y + + + C
Sbjct: 2175 STVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAYQLQS---------CP 2225
Query: 156 NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLP 215
+ + + N G + F+C +T +
Sbjct: 2226 DPRPFRNGFVIGNDFTVGQTI-----------------------SFECFPGYTLIGN--- 2259
Query: 216 ESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDH 275
+L C + + + CG + GT SP YPD YP +C WL+
Sbjct: 2260 SALTCLHGVS-RNWNHPLPRCEALCGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPG 2318
Query: 276 RKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPL-TVVSSSGQIRVH 334
+ + FT L D++ ++DG ++N + + F + L +V S+S QI +
Sbjct: 2319 NGIYINFT--VLQTEPIYDFITVWDGPDQNSPQ----IGQFSGNTALESVYSTSNQILIK 2372
Query: 335 FCAD 338
F +D
Sbjct: 2373 FHSD 2376
Score = 70.1 bits (170), Expect = 8e-12
Identities = 85/318 (26%), Positives = 123/318 (38%), Gaps = 50/318 (15%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKN-- 96
SG I SP +P YP +C W I N +I+++F F I+ N D+L I +
Sbjct: 1596 SGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEP----NYDFLYIYDGPDSN 1651
Query: 97 ---IESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFR 153
I S++ S +P SS + + + F SD ++S GF L Y K++ D
Sbjct: 1652 SPLIGSFQ--DSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY---KAKLRESCFDPGN 1706
Query: 154 CGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTC 213
NG + +K + T + Y + + TC
Sbjct: 1707 IMNGTRLGMDYKLGS--------------------TVTYYCDAGY-----VLQGYSTLTC 1741
Query: 214 LPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTG 273
+ G L C P CG GT SPNYP Y G NC + I
Sbjct: 1742 IMGDDGRPGWNRALP-----SCHAP-CGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVP 1795
Query: 274 DHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRV 333
V +F F+ T D V++YDG + LL L+ S L +SS QI +
Sbjct: 1796 KEFVVFGQFVFFQ---TSLHDVVEVYDGPTQQ-SSLLSSLSGSHSGESLP-LSSGNQITI 1850
Query: 334 HFCADKVNAARGFNATYQ 351
F + A+GF+ YQ
Sbjct: 1851 RFTSVGPITAKGFHFVYQ 1868
Score = 67.8 bits (164), Expect = 4e-11
Identities = 74/323 (22%), Positives = 125/323 (38%), Gaps = 64/323 (19%)
Query: 40 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETY----- 94
G I SPG+P Y +NC W I G I + F + +W +++ Y
Sbjct: 1948 GTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEH------NWDSLDFYDGGDN 2001
Query: 95 --KNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQF 152
+ SY G+TIP S+ +++++ F SD ++S GF L Y +
Sbjct: 2002 NAPRLGSY--SGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTA------------- 2046
Query: 153 RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT---- 208
G C PE ++ + GD + FQC ++
Sbjct: 2047 -IGLDSC-PEPQTPSSGIKIGD-----------------RYMVGDVVSFQCDQGYSLQGH 2087
Query: 209 KVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTW 268
TC+P ++ I + CG + F G SP +P YP +CTW
Sbjct: 2088 SHITCMPGPVR--------RWNYPIPICLAQCGGAMSDFSGVILSPGFPGNYPSSLDCTW 2139
Query: 269 LIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSS 328
I+ V L+F +F + DY+++ G E + R+ P ++ S++
Sbjct: 2140 TINLPIGFGVHLQFVNFSTE--TIHDYLEVRSGSSETSTVIGRL---SGPQIPSSLFSTT 2194
Query: 329 GQIRVHFCADKVNAARGFNATYQ 351
+ ++F +D +GF+ YQ
Sbjct: 2195 HETSLYFHSDYSQNKQGFHIVYQ 2217
Score = 66.6 bits (161), Expect = 9e-11
Identities = 46/119 (38%), Positives = 64/119 (53%), Gaps = 6/119 (5%)
Query: 235 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVI-LRFTDFKLDGTGYG 293
C V TCG L+ GTF SPN+P Y + C W+I + KVI + F +F L+ GY
Sbjct: 543 CKVKTCGSNLQGPSGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLE-IGY- 600
Query: 294 DYVKIYDGLE-ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQ 351
D + I DG E +P +L+VLT S P +VS S Q+ +H D+ + GF Y+
Sbjct: 601 DTLTIGDGGEVGDPRTVLQVLTG--SFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYK 657
Score = 65.9 bits (159), Expect = 2e-10
Identities = 85/342 (24%), Positives = 132/342 (38%), Gaps = 61/342 (17%)
Query: 35 IRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI--- 91
I A +G I SPG+P EYP +C W +R PG I I+F + D++T+
Sbjct: 2287 ITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTVLQTEPI----YDFITVWDG 2342
Query: 92 ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQ 151
+ + + G+T S+ + I I+FHSD S F L+Y + +
Sbjct: 2343 PDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS-GFFVLSYHAYQLRV------- 2394
Query: 152 FRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFT--- 208
C +P A DE F+ ++QCL FT
Sbjct: 2395 --CQPPPPVPNAEILTEDDE---------------------FEIGDIIRYQCLPGFTLVG 2431
Query: 209 -KVYTC-LPESLKCDGN---IDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPG 263
+ TC L E L+ DG L +E+ D G SP YPD YP
Sbjct: 2432 NAILTCRLGERLQMDGAPPVCQVLCPANELRLDST----------GVILSPGYPDSYPNL 2481
Query: 264 SNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLT 323
C W I + + F +F + D +++YDG N + + + D +
Sbjct: 2482 QMCAWSISVEKGYNITM-FVEFFQTEKEF-DVLQVYDG--PNIQSPVLISLSGDYSSAFN 2537
Query: 324 VVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGG 365
+ S+ ++ + + AD N +GF Y + +C E P G
Sbjct: 2538 ITSNGHEVFLQWSADHGNNKKGFRIRY-IAFYCSTPESPPHG 2578
Score = 48.1 bits (113), Expect = 3e-05
Identities = 36/119 (30%), Positives = 54/119 (45%), Gaps = 10/119 (8%)
Query: 235 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 294
CD CG ++ GT SP YP+FYP NCTW +D + V F F L+ + D
Sbjct: 1063 CDA-LCGGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLE--DHHD 1119
Query: 295 YVKIYDGLEENPHKLLRVLTAFDSHAPLTV---VSSSGQIRVHFCADKVNAARGFNATY 350
Y+ I EN + S P T+ + + + ++ F +D + GFN T+
Sbjct: 1120 YLLI----TENGSFTQPLARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITF 1174
Score = 46.2 bits (108), Expect = 1e-04
Identities = 74/320 (23%), Positives = 124/320 (38%), Gaps = 66/320 (20%)
Query: 40 GIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDI-QGSRRCNLDWLTIETYKNIE 98
GI+ SP +P Y C + I+ G+ I IS + F + QG D L I K+
Sbjct: 1250 GILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHLAQG------DVLKIYDGKDKT 1303
Query: 99 SY---RACGSTIPPPYISS-QDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRC 154
++ G+++ +SS + +W+ F+SD + +GF+L Y S +
Sbjct: 1304 THLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFE------------- 1350
Query: 155 GNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCL 214
+ C D + K ++ A T +Y C
Sbjct: 1351 --------------LSHCEDPGIPQFGYKISDQGHFAG--------------STIIYGCN 1382
Query: 215 P-ESLKCDGNIDCLDLGDE--IDCDVPTC-----GQWLKYFYGTFNSPNYPDFYPPGSNC 266
P +L + C+ G+ D +P+C G++ G SP YP Y C
Sbjct: 1383 PGYTLHGSSLLKCM-TGERRAWDYPLPSCIAECGGRFKGESSGRILSPGYPFPYDNNLRC 1441
Query: 267 TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVS 326
W+I+ V L+F F D D ++++DG EN LL+ ++ S P + S
Sbjct: 1442 MWMIEVDPGNIVSLQFLAF--DTEASHDILRVWDGPPEN-DMLLKEISG--SLIPEGIHS 1496
Query: 327 SSGQIRVHFCADKVNAARGF 346
+ + + F D + GF
Sbjct: 1497 TLNIVTIQFDTDFYISKSGF 1516
Score = 43.5 bits (101), Expect = 8e-04
Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 8/133 (6%)
Query: 235 CDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGD 294
C VP CG L GT SP YP+ Y NC W I + + ++ F + D
Sbjct: 1935 CIVP-CGGILTKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSFATEHN--WD 1991
Query: 295 YVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDG 354
+ YDG + N R+ + + P + S+S + ++F +D +A GF+ Y G
Sbjct: 1992 SLDFYDGGDNNAP---RLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIG 2048
Query: 355 F--CLPWEIPCGG 365
C + P G
Sbjct: 2049 LDSCPEPQTPSSG 2061
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 92.0 bits (227), Expect = 2e-18
Identities = 46/117 (39%), Positives = 58/117 (49%), Gaps = 7/117 (5%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT----MCQKEEFPCSRNG-VCYPR 410
C + C N C E+ +CDG CP+G DE+ T +C E+ C C P
Sbjct: 86 CADSDFTCD-NGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 411 SDRCNYQNHCPNGSDEKNCF-FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
S RC+ + C G+DE C C P F C N C+ +VCD DDCGDGSDE C
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 73.9 bits (180), Expect = 6e-13
Identities = 39/102 (38%), Positives = 51/102 (50%), Gaps = 10/102 (9%)
Query: 144 EPNCACDQFRCGN---GKCIPEAWKCNNMDECGDSSDE--EICAKEANPPTAAAFQPCAY 198
+P C +FRCG G CIPE W C+ +C D SDE E+C + T+A
Sbjct: 203 DPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATA 262
Query: 199 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 240
+QF C S C+ +CDG+ DC D DE DC + TC
Sbjct: 263 SQFACRSG-----ECVHLGWRCDGDRDCKDKSDEADCPLGTC 299
Score = 73.6 bits (179), Expect = 7e-13
Identities = 45/131 (34%), Positives = 54/131 (41%), Gaps = 19/131 (14%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT--MCQKEEFPCSRNG--VCYPRS 411
C P E CG N C CDG C +G DE C C EF C +G C P
Sbjct: 167 CAPHEFQCG-NRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPER 225
Query: 412 DRCNYQNHCPNGSDEKNCFFCQPG--------------NFHCKNNRCVFESWVCDSQDDC 457
C+ Q C + SDE +PG F C++ CV W CD DC
Sbjct: 226 WVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDC 285
Query: 458 GDGSDEENCPV 468
D SDE +CP+
Sbjct: 286 KDKSDEADCPL 296
Score = 68.2 bits (165), Expect = 3e-11
Identities = 36/103 (34%), Positives = 50/103 (48%), Gaps = 17/103 (16%)
Query: 140 GKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN 199
G+ +C DQF+C N +CIP W+C+ D+C D SDE+ C K+ CA +
Sbjct: 40 GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKT----------CADS 89
Query: 200 QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTC 240
F C + C+ E KCDG +C D DE + C C
Sbjct: 90 DFTCDNGH-----CIHERWKCDGEEECPDGSDESEATCTKQVC 127
Score = 68.2 bits (165), Expect = 3e-11
Identities = 30/72 (41%), Positives = 42/72 (58%), Gaps = 3/72 (4%)
Query: 394 CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVC 451
C+K++F C RN C P RC+ + C + SDE +C C +F C N C+ E W C
Sbjct: 47 CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
Query: 452 DSQDDCGDGSDE 463
D +++C DGSDE
Sbjct: 106 DGEEECPDGSDE 117
Score = 65.9 bits (159), Expect = 2e-10
Identities = 42/133 (31%), Positives = 57/133 (42%), Gaps = 21/133 (15%)
Query: 353 DGFCLPWEIPCGGNWG--CYTEQQRCDGYWHCPNGRDETNCTMCQK-------------- 396
D C P E CGG+ G C E+ CD + C + DE +C +
Sbjct: 203 DPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEA-AELCGRPGPGATSAPAACAT 261
Query: 397 -EEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDS 453
+F C R+G C RC+ C + SDE +C C+ F C + CV C+
Sbjct: 262 ASQFAC-RSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQ 320
Query: 454 QDDCGDGSDEENC 466
+ DC DGSDE C
Sbjct: 321 EQDCPDGSDEAGC 333
Score = 63.5 bits (153), Expect = 8e-10
Identities = 36/112 (32%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 366 NWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 423
N C RCD C + DE +C C +F C NG C +C+ + CP+G
Sbjct: 56 NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD-NGHCIHERWKCDGEEECPDG 114
Query: 424 SDEKNCF----FCQPGNFHC--KNNRCVFESWVCDSQDDCGDGSDEENCPVI 469
SDE C C +++CV SW CD + DC G+DE C +
Sbjct: 115 SDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL 166
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/97 (34%), Positives = 47/97 (48%), Gaps = 18/97 (18%)
Query: 147 CACDQFRCG--NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
C ++ CG + KC+P +W+C+ +C +DE CA CA ++FQC
Sbjct: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA-----------TLCAPHEFQCG 175
Query: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCG 241
+R +CL CDG+ DC D DE C P CG
Sbjct: 176 NR-----SCLAAVFVCDGDDDCGDGSDERGCADPACG 207
Score = 59.3 bits (142), Expect = 1e-08
Identities = 31/86 (36%), Positives = 40/86 (46%), Gaps = 12/86 (13%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
CA +F+CGN C+ + C+ D+CGD SDE CA A C +F+C
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPA----------CGPREFRCGG- 215
Query: 207 FTKVYTCLPESLKCDGNIDCLDLGDE 232
C+PE CD DC D DE
Sbjct: 216 -DGGGACIPERWVCDRQFDCEDRSDE 240
Score = 51.2 bits (121), Expect = 4e-06
Identities = 18/36 (50%), Positives = 23/36 (63%)
Query: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 467
C+ F C+N RC+ W CD DDC D SDE++CP
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP 82
Score = 47.4 bits (111), Expect = 6e-05
Identities = 36/128 (28%), Positives = 50/128 (39%), Gaps = 19/128 (14%)
Query: 141 KSEEPNCAC-----DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 195
KS+E +C D+F+CG+G C+ CN +C D SDE C + N
Sbjct: 288 KSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLN--------E 339
Query: 196 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLD---LGDEIDC-DVPTCGQWLKYFYGTF 251
C +N C T + + C LD GD +C D C Q + G F
Sbjct: 340 CLHNNGGCSHICTDLK--IGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 252 NSPNYPDF 259
YP +
Sbjct: 398 KCECYPGY 405
Score = 47.0 bits (110), Expect = 7e-05
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 16/90 (17%)
Query: 147 CA-CDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 205
CA QF C +G+C+ W+C+ +C D SDE C C ++FQC
Sbjct: 259 CATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC----------PLGTCRGDEFQCGD 308
Query: 206 RFTKVYTCLPESLKCDGNIDCLDLGDEIDC 235
TC+ C+ DC D DE C
Sbjct: 309 G-----TCVLAIKHCNQEQDCPDGSDEAGC 333
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 92.0 bits (227), Expect = 2e-18
Identities = 46/117 (39%), Positives = 58/117 (49%), Gaps = 7/117 (5%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT----MCQKEEFPCSRNG-VCYPR 410
C + C N C E+ +CDG CP+G DE+ T +C E+ C C P
Sbjct: 86 CADSDFTCD-NGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPA 144
Query: 411 SDRCNYQNHCPNGSDEKNCF-FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
S RC+ + C G+DE C C P F C N C+ +VCD DDCGDGSDE C
Sbjct: 145 SWRCDGEKDCEGGADEAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
Score = 73.9 bits (180), Expect = 6e-13
Identities = 39/102 (38%), Positives = 51/102 (50%), Gaps = 10/102 (9%)
Query: 144 EPNCACDQFRCGN---GKCIPEAWKCNNMDECGDSSDE--EICAKEANPPTAAAFQPCAY 198
+P C +FRCG G CIPE W C+ +C D SDE E+C + T+A
Sbjct: 203 DPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATA 262
Query: 199 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTC 240
+QF C S C+ +CDG+ DC D DE DC + TC
Sbjct: 263 SQFACRSG-----ECVHLGWRCDGDRDCKDKSDEADCPLGTC 299
Score = 73.6 bits (179), Expect = 7e-13
Identities = 45/131 (34%), Positives = 54/131 (41%), Gaps = 19/131 (14%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCT--MCQKEEFPCSRNG--VCYPRS 411
C P E CG N C CDG C +G DE C C EF C +G C P
Sbjct: 167 CAPHEFQCG-NRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPER 225
Query: 412 DRCNYQNHCPNGSDEKNCFFCQPG--------------NFHCKNNRCVFESWVCDSQDDC 457
C+ Q C + SDE +PG F C++ CV W CD DC
Sbjct: 226 WVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGECVHLGWRCDGDRDC 285
Query: 458 GDGSDEENCPV 468
D SDE +CP+
Sbjct: 286 KDKSDEADCPL 296
Score = 68.2 bits (165), Expect = 3e-11
Identities = 36/103 (34%), Positives = 50/103 (48%), Gaps = 17/103 (16%)
Query: 140 GKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYN 199
G+ +C DQF+C N +CIP W+C+ D+C D SDE+ C K+ CA +
Sbjct: 40 GQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKT----------CADS 89
Query: 200 QFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEID--CDVPTC 240
F C + C+ E KCDG +C D DE + C C
Sbjct: 90 DFTCDNGH-----CIHERWKCDGEEECPDGSDESEATCTKQVC 127
Score = 68.2 bits (165), Expect = 3e-11
Identities = 30/72 (41%), Positives = 42/72 (58%), Gaps = 3/72 (4%)
Query: 394 CQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVC 451
C+K++F C RN C P RC+ + C + SDE +C C +F C N C+ E W C
Sbjct: 47 CEKDQFQC-RNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKC 105
Query: 452 DSQDDCGDGSDE 463
D +++C DGSDE
Sbjct: 106 DGEEECPDGSDE 117
Score = 65.9 bits (159), Expect = 2e-10
Identities = 42/133 (31%), Positives = 57/133 (42%), Gaps = 21/133 (15%)
Query: 353 DGFCLPWEIPCGGNWG--CYTEQQRCDGYWHCPNGRDETNCTMCQK-------------- 396
D C P E CGG+ G C E+ CD + C + DE +C +
Sbjct: 203 DPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEA-AELCGRPGPGATSAPAACAT 261
Query: 397 -EEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDS 453
+F C R+G C RC+ C + SDE +C C+ F C + CV C+
Sbjct: 262 ASQFAC-RSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQ 320
Query: 454 QDDCGDGSDEENC 466
+ DC DGSDE C
Sbjct: 321 EQDCPDGSDEAGC 333
Score = 63.5 bits (153), Expect = 8e-10
Identities = 36/112 (32%), Positives = 49/112 (43%), Gaps = 9/112 (8%)
Query: 366 NWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDRCNYQNHCPNG 423
N C RCD C + DE +C C +F C NG C +C+ + CP+G
Sbjct: 56 NERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCD-NGHCIHERWKCDGEEECPDG 114
Query: 424 SDEKNCF----FCQPGNFHC--KNNRCVFESWVCDSQDDCGDGSDEENCPVI 469
SDE C C +++CV SW CD + DC G+DE C +
Sbjct: 115 SDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL 166
Score = 62.0 bits (149), Expect = 2e-09
Identities = 33/97 (34%), Positives = 47/97 (48%), Gaps = 18/97 (18%)
Query: 147 CACDQFRCG--NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
C ++ CG + KC+P +W+C+ +C +DE CA CA ++FQC
Sbjct: 127 CPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA-----------TLCAPHEFQCG 175
Query: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCG 241
+R +CL CDG+ DC D DE C P CG
Sbjct: 176 NR-----SCLAAVFVCDGDDDCGDGSDERGCADPACG 207
Score = 59.3 bits (142), Expect = 1e-08
Identities = 31/86 (36%), Positives = 40/86 (46%), Gaps = 12/86 (13%)
Query: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSR 206
CA +F+CGN C+ + C+ D+CGD SDE CA A C +F+C
Sbjct: 167 CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPA----------CGPREFRCGG- 215
Query: 207 FTKVYTCLPESLKCDGNIDCLDLGDE 232
C+PE CD DC D DE
Sbjct: 216 -DGGGACIPERWVCDRQFDCEDRSDE 240
Score = 51.2 bits (121), Expect = 4e-06
Identities = 18/36 (50%), Positives = 23/36 (63%)
Query: 432 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 467
C+ F C+N RC+ W CD DDC D SDE++CP
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCP 82
Score = 47.4 bits (111), Expect = 6e-05
Identities = 36/128 (28%), Positives = 50/128 (39%), Gaps = 19/128 (14%)
Query: 141 KSEEPNCAC-----DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQP 195
KS+E +C D+F+CG+G C+ CN +C D SDE C + N
Sbjct: 288 KSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLN--------E 339
Query: 196 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLD---LGDEIDC-DVPTCGQWLKYFYGTF 251
C +N C T + + C LD GD +C D C Q + G F
Sbjct: 340 CLHNNGGCSHICTDLK--IGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYF 397
Query: 252 NSPNYPDF 259
YP +
Sbjct: 398 KCECYPGY 405
Score = 47.0 bits (110), Expect = 7e-05
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 16/90 (17%)
Query: 147 CA-CDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLS 205
CA QF C +G+C+ W+C+ +C D SDE C C ++FQC
Sbjct: 259 CATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC----------PLGTCRGDEFQCGD 308
Query: 206 RFTKVYTCLPESLKCDGNIDCLDLGDEIDC 235
TC+ C+ DC D DE C
Sbjct: 309 G-----TCVLAIKHCNQEQDCPDGSDEAGC 333
>gi|239755390 PREDICTED: similar to DMBT1 isoform 1 [Homo sapiens]
Length = 1662
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/347 (22%), Positives = 135/347 (38%), Gaps = 41/347 (11%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYK 95
SG +SP +P+ YP C W I N G I + F + ++ C+ D++ I
Sbjct: 1023 SGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNS 1082
Query: 96 NIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 155
++ + C T + SS + + I F SD + GF LA+++ +
Sbjct: 1083 SLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGF-LAWYNSFPSDATLRLVNLNSS 1140
Query: 156 NGKCIPEA-------WKCNNMDECGDSSDEEICAKEA---------NPPTAAAFQPCAYN 199
G C W D E +C + N + P +
Sbjct: 1141 YGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLD 1200
Query: 200 QFQCLSRFTKVYTCLPE---SLKCDGNIDC--LDLGDEIDCDVP-----------TCGQW 243
+C + ++ C S C+ D + G+ + P +CG +
Sbjct: 1201 DVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGF 1260
Query: 244 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE 303
L G F+SP YP YP + C W I+ ++ +V + F D +L+G DY++++DG
Sbjct: 1261 LSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDG-- 1318
Query: 304 ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 350
P++ ++ A + SSS + + F +D RGF A Y
Sbjct: 1319 --PYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1363
Score = 64.7 bits (156), Expect = 3e-10
Identities = 38/121 (31%), Positives = 59/121 (48%), Gaps = 7/121 (5%)
Query: 26 YACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCN 85
Y+CG Q PSG +SP +P YP C W I +T+ F+D ++G CN
Sbjct: 1255 YSCGGFLSQ---PSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CN 1309
Query: 86 LDWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSE 143
D++ + Y++ + SS + + IRF SD +I+R+GFR Y+S S
Sbjct: 1310 YDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSN 1369
Query: 144 E 144
+
Sbjct: 1370 D 1370
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/159 (30%), Positives = 70/159 (44%), Gaps = 27/159 (16%)
Query: 240 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDG--TGYGDYVK 297
CG +L Y GTF+SP+YP +YP + C W I+ ++ L F++ KL+ DYV+
Sbjct: 1015 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1074
Query: 298 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY------- 350
I+DG + L ++ D+ T SS ++ +HF +D GF A Y
Sbjct: 1075 IFDGSLNSSLLLGKICN--DTRQIFT--SSYNRMTIHFRSDISFQNTGFLAWYNSFPSDA 1130
Query: 351 --------QVDGFCL-PWEIPCGGNWGCYTEQQRCDGYW 380
G C EI GG WG CD W
Sbjct: 1131 TLRLVNLNSSYGLCAGRVEIYHGGTWGTV-----CDDSW 1164
>gi|239755388 PREDICTED: similar to DMBT1 isoform 2 [Homo sapiens]
Length = 1788
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/347 (22%), Positives = 135/347 (38%), Gaps = 41/347 (11%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYK 95
SG +SP +P+ YP C W I N G I + F + ++ C+ D++ I
Sbjct: 1149 SGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNS 1208
Query: 96 NIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 155
++ + C T + SS + + I F SD + GF LA+++ +
Sbjct: 1209 SLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGF-LAWYNSFPSDATLRLVNLNSS 1266
Query: 156 NGKCIPEA-------WKCNNMDECGDSSDEEICAKEA---------NPPTAAAFQPCAYN 199
G C W D E +C + N + P +
Sbjct: 1267 YGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLD 1326
Query: 200 QFQCLSRFTKVYTCLPE---SLKCDGNIDC--LDLGDEIDCDVP-----------TCGQW 243
+C + ++ C S C+ D + G+ + P +CG +
Sbjct: 1327 DVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGF 1386
Query: 244 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE 303
L G F+SP YP YP + C W I+ ++ +V + F D +L+G DY++++DG
Sbjct: 1387 LSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDG-- 1444
Query: 304 ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 350
P++ ++ A + SSS + + F +D RGF A Y
Sbjct: 1445 --PYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1489
Score = 64.7 bits (156), Expect = 3e-10
Identities = 38/121 (31%), Positives = 59/121 (48%), Gaps = 7/121 (5%)
Query: 26 YACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCN 85
Y+CG Q PSG +SP +P YP C W I +T+ F+D ++G CN
Sbjct: 1381 YSCGGFLSQ---PSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CN 1435
Query: 86 LDWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSE 143
D++ + Y++ + SS + + IRF SD +I+R+GFR Y+S S
Sbjct: 1436 YDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSN 1495
Query: 144 E 144
+
Sbjct: 1496 D 1496
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/159 (30%), Positives = 70/159 (44%), Gaps = 27/159 (16%)
Query: 240 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDG--TGYGDYVK 297
CG +L Y GTF+SP+YP +YP + C W I+ ++ L F++ KL+ DYV+
Sbjct: 1141 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1200
Query: 298 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY------- 350
I+DG + L ++ D+ T SS ++ +HF +D GF A Y
Sbjct: 1201 IFDGSLNSSLLLGKICN--DTRQIFT--SSYNRMTIHFRSDISFQNTGFLAWYNSFPSDA 1256
Query: 351 --------QVDGFCL-PWEIPCGGNWGCYTEQQRCDGYW 380
G C EI GG WG CD W
Sbjct: 1257 TLRLVNLNSSYGLCAGRVEIYHGGTWGTV-----CDDSW 1290
>gi|148539844 deleted in malignant brain tumors 1 isoform c precursor
[Homo sapiens]
Length = 2403
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/347 (22%), Positives = 135/347 (38%), Gaps = 41/347 (11%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYK 95
SG +SP +P+ YP C W I N G I + F + ++ C+ D++ I
Sbjct: 1764 SGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNS 1823
Query: 96 NIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 155
++ + C T + SS + + I F SD + GF LA+++ +
Sbjct: 1824 SLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGF-LAWYNSFPSDATLRLVNLNSS 1881
Query: 156 NGKCIPEA-------WKCNNMDECGDSSDEEICAKEA---------NPPTAAAFQPCAYN 199
G C W D E +C + N + P +
Sbjct: 1882 YGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLD 1941
Query: 200 QFQCLSRFTKVYTCLPE---SLKCDGNIDC--LDLGDEIDCDVP-----------TCGQW 243
+C + ++ C S C+ D + G+ + P +CG +
Sbjct: 1942 DVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGF 2001
Query: 244 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE 303
L G F+SP YP YP + C W I+ ++ +V + F D +L+G DY++++DG
Sbjct: 2002 LSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDG-- 2059
Query: 304 ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 350
P++ ++ A + SSS + + F +D RGF A Y
Sbjct: 2060 --PYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 2104
Score = 64.7 bits (156), Expect = 3e-10
Identities = 38/121 (31%), Positives = 59/121 (48%), Gaps = 7/121 (5%)
Query: 26 YACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCN 85
Y+CG Q PSG +SP +P YP C W I +T+ F+D ++G CN
Sbjct: 1996 YSCGGFLSQ---PSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CN 2050
Query: 86 LDWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSE 143
D++ + Y++ + SS + + IRF SD +I+R+GFR Y+S S
Sbjct: 2051 YDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSN 2110
Query: 144 E 144
+
Sbjct: 2111 D 2111
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/159 (30%), Positives = 70/159 (44%), Gaps = 27/159 (16%)
Query: 240 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDG--TGYGDYVK 297
CG +L Y GTF+SP+YP +YP + C W I+ ++ L F++ KL+ DYV+
Sbjct: 1756 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1815
Query: 298 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY------- 350
I+DG + L ++ D+ T SS ++ +HF +D GF A Y
Sbjct: 1816 IFDGSLNSSLLLGKICN--DTRQIFT--SSYNRMTIHFRSDISFQNTGFLAWYNSFPSDA 1871
Query: 351 --------QVDGFCL-PWEIPCGGNWGCYTEQQRCDGYW 380
G C EI GG WG CD W
Sbjct: 1872 TLRLVNLNSSYGLCAGRVEIYHGGTWGTV-----CDDSW 1905
>gi|148539842 deleted in malignant brain tumors 1 isoform b precursor
[Homo sapiens]
Length = 2413
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/347 (22%), Positives = 135/347 (38%), Gaps = 41/347 (11%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYK 95
SG +SP +P+ YP C W I N G I + F + ++ C+ D++ I
Sbjct: 1774 SGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNS 1833
Query: 96 NIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 155
++ + C T + SS + + I F SD + GF LA+++ +
Sbjct: 1834 SLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGF-LAWYNSFPSDATLRLVNLNSS 1891
Query: 156 NGKCIPEA-------WKCNNMDECGDSSDEEICAKEA---------NPPTAAAFQPCAYN 199
G C W D E +C + N + P +
Sbjct: 1892 YGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLD 1951
Query: 200 QFQCLSRFTKVYTCLPE---SLKCDGNIDC--LDLGDEIDCDVP-----------TCGQW 243
+C + ++ C S C+ D + G+ + P +CG +
Sbjct: 1952 DVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGF 2011
Query: 244 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE 303
L G F+SP YP YP + C W I+ ++ +V + F D +L+G DY++++DG
Sbjct: 2012 LSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDG-- 2069
Query: 304 ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 350
P++ ++ A + SSS + + F +D RGF A Y
Sbjct: 2070 --PYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 2114
Score = 64.7 bits (156), Expect = 3e-10
Identities = 38/121 (31%), Positives = 59/121 (48%), Gaps = 7/121 (5%)
Query: 26 YACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCN 85
Y+CG Q PSG +SP +P YP C W I +T+ F+D ++G CN
Sbjct: 2006 YSCGGFLSQ---PSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CN 2060
Query: 86 LDWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSE 143
D++ + Y++ + SS + + IRF SD +I+R+GFR Y+S S
Sbjct: 2061 YDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSN 2120
Query: 144 E 144
+
Sbjct: 2121 D 2121
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/159 (30%), Positives = 70/159 (44%), Gaps = 27/159 (16%)
Query: 240 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDG--TGYGDYVK 297
CG +L Y GTF+SP+YP +YP + C W I+ ++ L F++ KL+ DYV+
Sbjct: 1766 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1825
Query: 298 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY------- 350
I+DG + L ++ D+ T SS ++ +HF +D GF A Y
Sbjct: 1826 IFDGSLNSSLLLGKICN--DTRQIFT--SSYNRMTIHFRSDISFQNTGFLAWYNSFPSDA 1881
Query: 351 --------QVDGFCL-PWEIPCGGNWGCYTEQQRCDGYW 380
G C EI GG WG CD W
Sbjct: 1882 TLRLVNLNSSYGLCAGRVEIYHGGTWGTV-----CDDSW 1915
>gi|148539840 deleted in malignant brain tumors 1 isoform a precursor
[Homo sapiens]
Length = 1785
Score = 92.0 bits (227), Expect = 2e-18
Identities = 79/347 (22%), Positives = 135/347 (38%), Gaps = 41/347 (11%)
Query: 39 SGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTI---ETYK 95
SG +SP +P+ YP C W I N G I + F + ++ C+ D++ I
Sbjct: 1146 SGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNS 1205
Query: 96 NIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCG 155
++ + C T + SS + + I F SD + GF LA+++ +
Sbjct: 1206 SLLLGKICNDT-RQIFTSSYNRMTIHFRSDISFQNTGF-LAWYNSFPSDATLRLVNLNSS 1263
Query: 156 NGKCIPEA-------WKCNNMDECGDSSDEEICAKEA---------NPPTAAAFQPCAYN 199
G C W D E +C + N + P +
Sbjct: 1264 YGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLD 1323
Query: 200 QFQCLSRFTKVYTCLPE---SLKCDGNIDC--LDLGDEIDCDVP-----------TCGQW 243
+C + ++ C S C+ D + G+ + P +CG +
Sbjct: 1324 DVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGF 1383
Query: 244 LKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLE 303
L G F+SP YP YP + C W I+ ++ +V + F D +L+G DY++++DG
Sbjct: 1384 LSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDG-- 1441
Query: 304 ENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 350
P++ ++ A + SSS + + F +D RGF A Y
Sbjct: 1442 --PYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEY 1486
Score = 64.7 bits (156), Expect = 3e-10
Identities = 38/121 (31%), Positives = 59/121 (48%), Gaps = 7/121 (5%)
Query: 26 YACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCN 85
Y+CG Q PSG +SP +P YP C W I +T+ F+D ++G CN
Sbjct: 1378 YSCGGFLSQ---PSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGG--CN 1432
Query: 86 LDWLTI--ETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSE 143
D++ + Y++ + SS + + IRF SD +I+R+GFR Y+S S
Sbjct: 1433 YDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSN 1492
Query: 144 E 144
+
Sbjct: 1493 D 1493
Score = 61.2 bits (147), Expect = 4e-09
Identities = 49/159 (30%), Positives = 70/159 (44%), Gaps = 27/159 (16%)
Query: 240 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDG--TGYGDYVK 297
CG +L Y GTF+SP+YP +YP + C W I+ ++ L F++ KL+ DYV+
Sbjct: 1138 CGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVE 1197
Query: 298 IYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY------- 350
I+DG + L ++ D+ T SS ++ +HF +D GF A Y
Sbjct: 1198 IFDGSLNSSLLLGKICN--DTRQIFT--SSYNRMTIHFRSDISFQNTGFLAWYNSFPSDA 1253
Query: 351 --------QVDGFCL-PWEIPCGGNWGCYTEQQRCDGYW 380
G C EI GG WG CD W
Sbjct: 1254 TLRLVNLNSSYGLCAGRVEIYHGGTWGTV-----CDDSW 1287
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 91.3 bits (225), Expect = 3e-18
Identities = 55/152 (36%), Positives = 75/152 (49%), Gaps = 6/152 (3%)
Query: 356 CLPWEIPC-GGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRC 414
C P + C G C RCDG+ C + DE NC +C + +F C+ +G C + RC
Sbjct: 1249 CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCA-SGQCIDGALRC 1307
Query: 415 NYQNHCPNGSDEKNC-FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC-PVIVPT 472
N +C + SDEKNC C F C N +C+ + CD DC D SDE +C P P
Sbjct: 1308 NGDANCQDKSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPA 1367
Query: 473 RVITAAVIGSLICGLLLVIALGCTCKLYSLRM 504
T V GS+I G+++ I + T RM
Sbjct: 1368 PQATNTV-GSVI-GVIVTIFVSGTVYFICQRM 1397
Score = 68.6 bits (166), Expect = 2e-11
Identities = 36/97 (37%), Positives = 50/97 (51%), Gaps = 19/97 (19%)
Query: 143 EEPNCACDQFRCGNGK--CIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQ 200
E P C+ QF C G+ CIP AW+C+ EC D SDE C C+ +Q
Sbjct: 1245 EPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC------------PVCSESQ 1292
Query: 201 FQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDV 237
FQC S C+ +L+C+G+ +C D DE +C+V
Sbjct: 1293 FQCASG-----QCIDGALRCNGDANCQDKSDEKNCEV 1324
Score = 65.9 bits (159), Expect = 2e-10
Identities = 33/91 (36%), Positives = 46/91 (50%), Gaps = 16/91 (17%)
Query: 145 PNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCL 204
P C+ QF+C +G+CI A +CN C D SDE+ C C +QF+C
Sbjct: 1286 PVCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCE-----------VLCLIDQFRCA 1334
Query: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDC 235
+ C+ + KCD N+DC D DE+DC
Sbjct: 1335 NG-----QCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 63.5 bits (153), Expect = 8e-10
Identities = 32/99 (32%), Positives = 48/99 (48%), Gaps = 4/99 (4%)
Query: 375 RCDGYWHCPNGRDETNC---TMCQKEEFPCSRNGV-CYPRSDRCNYQNHCPNGSDEKNCF 430
RC H +DE +C C ++F C + C P + RC+ C + SDE NC
Sbjct: 1227 RCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP 1286
Query: 431 FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 469
C F C + +C+ + C+ +C D SDE+NC V+
Sbjct: 1287 VCSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEVL 1325
Score = 48.1 bits (113), Expect = 3e-05
Identities = 24/55 (43%), Positives = 30/55 (54%), Gaps = 4/55 (7%)
Query: 141 KSEEPNCAC----DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA 191
KS+E NC DQFRC NG+CI + KC++ +C D SDE C P A
Sbjct: 1316 KSDEKNCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQA 1370
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 90.1 bits (222), Expect = 8e-18
Identities = 46/118 (38%), Positives = 63/118 (53%), Gaps = 8/118 (6%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET--NCTM--CQKEEFPCSRNGV-CYPR 410
C + C N C + +CDG C +G DE+ C M C+ E C + C P
Sbjct: 72 CAESDFVCN-NGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPV 130
Query: 411 SDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
S RC+ +N C +G DE+NC C P F C + RC+ ++VC+ QDDC DGSDE +C
Sbjct: 131 SWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 188
Score = 82.0 bits (201), Expect = 2e-15
Identities = 76/284 (26%), Positives = 106/284 (37%), Gaps = 54/284 (19%)
Query: 196 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPN 255
C +QFQC + C+ KCDG+ DC+D DE +C TC +
Sbjct: 33 CEPSQFQCTNG-----RCITLLWKCDGDEDCVDGSDEKNCVKKTCAE------------- 74
Query: 256 YPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTA 315
DF C + +K DG DG +E+P + +
Sbjct: 75 -SDFVCNNGQCV--------------PSRWKCDGD-----PDCEDGSDESPEQC--HMRT 112
Query: 316 FDSHAPLTVVSSSGQIRVHF-CADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQ 374
H S+ I V + C + + G + + C P E C C +
Sbjct: 113 CRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSG-RCISRNF 171
Query: 375 RCDGYWHCPNGRDETNCT--MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE--KNC- 429
C+G C +G DE +C C EF CS + C P S C+ C + SDE + C
Sbjct: 172 VCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCG 230
Query: 430 ------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 467
C C + C+ + W CD DC DGSDE NCP
Sbjct: 231 RQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP 274
Score = 81.6 bits (200), Expect = 3e-15
Identities = 45/114 (39%), Positives = 59/114 (51%), Gaps = 8/114 (7%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 413
C EI CG C ++ RCDG C +G DE NC C+ ++F C +G C S +
Sbjct: 239 CPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECE-DGSCIHGSRQ 296
Query: 414 CNYQNHCPNGSDEKNCFFCQ----PGNFHCKNNRCVFESWVCDSQDDCGDGSDE 463
CN C +GSDE NC PG F C++ C+ S VC+ + DC D SDE
Sbjct: 297 CNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Score = 78.2 bits (191), Expect = 3e-14
Identities = 80/342 (23%), Positives = 122/342 (35%), Gaps = 77/342 (22%)
Query: 140 GKSEEPN------CACDQFRCG--NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA 191
G E P C + CG + +CIP +W+C+ ++C DEE C
Sbjct: 100 GSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNIT------ 153
Query: 192 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTF 251
C+ ++F C S C+ + C+G DC D DE+DC PTCG
Sbjct: 154 ----CSPDEFTCSSG-----RCISRNFVCNGQDDCSDGSDELDCAPPTCGA--------- 195
Query: 252 NSPNYPDFYPPGSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHK 308
+F S+C +W+ D D D +E+ +
Sbjct: 196 -----HEFQCSTSSCIPISWVCD----------------------DDADCSDQSDESLEQ 228
Query: 309 LLRVLTAFDSHAPLTVVSSSGQI--RVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGN 366
R + SG+ + C + G + C P + C +
Sbjct: 229 CGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFEC-ED 287
Query: 367 WGCYTEQQRCDGYWHCPNGRDETNCTMCQK----EEFPCSRNGVCYPRSDRCNYQNHCPN 422
C ++C+G C +G DE NC + +F C R+G C S CN + C +
Sbjct: 288 GSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKC-RSGECIDISKVCNQEQDCRD 346
Query: 423 GSDE--KNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDG 460
SDE K C C N C + + + V + DC G
Sbjct: 347 WSDEPLKECHINECLVNNGGCSH---ICKDLVIGYECDCAAG 385
Score = 70.5 bits (171), Expect = 6e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 17/104 (16%)
Query: 139 SGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 198
+G + C QF+C NG+CI WKC+ ++C D SDE+ C K+ CA
Sbjct: 25 TGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKT----------CAE 74
Query: 199 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEI--DCDVPTC 240
+ F C + C+P KCDG+ DC D DE C + TC
Sbjct: 75 SDFVCNNG-----QCVPSRWKCDGDPDCEDGSDESPEQCHMRTC 113
Score = 69.7 bits (169), Expect = 1e-11
Identities = 40/108 (37%), Positives = 54/108 (50%), Gaps = 22/108 (20%)
Query: 139 SGKSEEP----NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ 194
SG+ EE C+ D+F C +G+CI + CN D+C D SDE CA PPT
Sbjct: 142 SGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCA----PPT----- 192
Query: 195 PCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQ 242
C ++FQC +C+P S CD + DC D DE + CG+
Sbjct: 193 -CGAHEFQC-----STSSCIPISWVCDDDADCSDQSDE---SLEQCGR 231
Score = 66.6 bits (161), Expect = 9e-11
Identities = 39/113 (34%), Positives = 51/113 (45%), Gaps = 7/113 (6%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCN 415
C+P C + C Q + C GR T C E C +G C + RC+
Sbjct: 205 CIPISWVCDDDADC--SDQSDESLEQC--GRQPVIHTKCPASEIQCG-SGECIHKKWRCD 259
Query: 416 YQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
C +GSDE NC C+P F C++ C+ S C+ DC DGSDE NC
Sbjct: 260 GDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Score = 32.7 bits (73), Expect = 1.4
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 39/114 (34%)
Query: 142 SEEPNCA----C---DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ 194
S+E NC C +F+C +G+CI + CN +C D SDE + +
Sbjct: 307 SDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPL-------------K 353
Query: 195 PCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDC-------DVPTCG 241
C N+ CL + C L +G E DC D TCG
Sbjct: 354 ECHINE------------CLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCG 395
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 90.1 bits (222), Expect = 8e-18
Identities = 46/118 (38%), Positives = 63/118 (53%), Gaps = 8/118 (6%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDET--NCTM--CQKEEFPCSRNGV-CYPR 410
C + C N C + +CDG C +G DE+ C M C+ E C + C P
Sbjct: 72 CAESDFVCN-NGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPV 130
Query: 411 SDRCNYQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
S RC+ +N C +G DE+NC C P F C + RC+ ++VC+ QDDC DGSDE +C
Sbjct: 131 SWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC 188
Score = 82.0 bits (201), Expect = 2e-15
Identities = 76/284 (26%), Positives = 106/284 (37%), Gaps = 54/284 (19%)
Query: 196 CAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPN 255
C +QFQC + C+ KCDG+ DC+D DE +C TC +
Sbjct: 33 CEPSQFQCTNG-----RCITLLWKCDGDEDCVDGSDEKNCVKKTCAE------------- 74
Query: 256 YPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTA 315
DF C + +K DG DG +E+P + +
Sbjct: 75 -SDFVCNNGQCV--------------PSRWKCDGD-----PDCEDGSDESPEQC--HMRT 112
Query: 316 FDSHAPLTVVSSSGQIRVHF-CADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQ 374
H S+ I V + C + + G + + C P E C C +
Sbjct: 113 CRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSG-RCISRNF 171
Query: 375 RCDGYWHCPNGRDETNCT--MCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDE--KNC- 429
C+G C +G DE +C C EF CS + C P S C+ C + SDE + C
Sbjct: 172 VCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCG 230
Query: 430 ------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCP 467
C C + C+ + W CD DC DGSDE NCP
Sbjct: 231 RQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP 274
Score = 81.6 bits (200), Expect = 3e-15
Identities = 45/114 (39%), Positives = 59/114 (51%), Gaps = 8/114 (7%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM--CQKEEFPCSRNGVCYPRSDR 413
C EI CG C ++ RCDG C +G DE NC C+ ++F C +G C S +
Sbjct: 239 CPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECE-DGSCIHGSRQ 296
Query: 414 CNYQNHCPNGSDEKNCFFCQ----PGNFHCKNNRCVFESWVCDSQDDCGDGSDE 463
CN C +GSDE NC PG F C++ C+ S VC+ + DC D SDE
Sbjct: 297 CNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Score = 78.2 bits (191), Expect = 3e-14
Identities = 80/342 (23%), Positives = 122/342 (35%), Gaps = 77/342 (22%)
Query: 140 GKSEEPN------CACDQFRCG--NGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA 191
G E P C + CG + +CIP +W+C+ ++C DEE C
Sbjct: 100 GSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNIT------ 153
Query: 192 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTF 251
C+ ++F C S C+ + C+G DC D DE+DC PTCG
Sbjct: 154 ----CSPDEFTCSSG-----RCISRNFVCNGQDDCSDGSDELDCAPPTCGA--------- 195
Query: 252 NSPNYPDFYPPGSNC---TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHK 308
+F S+C +W+ D D D +E+ +
Sbjct: 196 -----HEFQCSTSSCIPISWVCD----------------------DDADCSDQSDESLEQ 228
Query: 309 LLRVLTAFDSHAPLTVVSSSGQI--RVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGN 366
R + SG+ + C + G + C P + C +
Sbjct: 229 CGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFEC-ED 287
Query: 367 WGCYTEQQRCDGYWHCPNGRDETNCTMCQK----EEFPCSRNGVCYPRSDRCNYQNHCPN 422
C ++C+G C +G DE NC + +F C R+G C S CN + C +
Sbjct: 288 GSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKC-RSGECIDISKVCNQEQDCRD 346
Query: 423 GSDE--KNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDG 460
SDE K C C N C + + + V + DC G
Sbjct: 347 WSDEPLKECHINECLVNNGGCSH---ICKDLVIGYECDCAAG 385
Score = 70.5 bits (171), Expect = 6e-12
Identities = 37/104 (35%), Positives = 51/104 (49%), Gaps = 17/104 (16%)
Query: 139 SGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAY 198
+G + C QF+C NG+CI WKC+ ++C D SDE+ C K+ CA
Sbjct: 25 TGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKT----------CAE 74
Query: 199 NQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEI--DCDVPTC 240
+ F C + C+P KCDG+ DC D DE C + TC
Sbjct: 75 SDFVCNNG-----QCVPSRWKCDGDPDCEDGSDESPEQCHMRTC 113
Score = 69.7 bits (169), Expect = 1e-11
Identities = 40/108 (37%), Positives = 54/108 (50%), Gaps = 22/108 (20%)
Query: 139 SGKSEEP----NCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ 194
SG+ EE C+ D+F C +G+CI + CN D+C D SDE CA PPT
Sbjct: 142 SGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCA----PPT----- 192
Query: 195 PCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQ 242
C ++FQC +C+P S CD + DC D DE + CG+
Sbjct: 193 -CGAHEFQC-----STSSCIPISWVCDDDADCSDQSDE---SLEQCGR 231
Score = 66.6 bits (161), Expect = 9e-11
Identities = 39/113 (34%), Positives = 51/113 (45%), Gaps = 7/113 (6%)
Query: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCN 415
C+P C + C Q + C GR T C E C +G C + RC+
Sbjct: 205 CIPISWVCDDDADC--SDQSDESLEQC--GRQPVIHTKCPASEIQCG-SGECIHKKWRCD 259
Query: 416 YQNHCPNGSDEKNC--FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
C +GSDE NC C+P F C++ C+ S C+ DC DGSDE NC
Sbjct: 260 GDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
Score = 32.7 bits (73), Expect = 1.4
Identities = 31/114 (27%), Positives = 43/114 (37%), Gaps = 39/114 (34%)
Query: 142 SEEPNCA----C---DQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQ 194
S+E NC C +F+C +G+CI + CN +C D SDE + +
Sbjct: 307 SDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPL-------------K 353
Query: 195 PCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDC-------DVPTCG 241
C N+ CL + C L +G E DC D TCG
Sbjct: 354 ECHINE------------CLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCG 395
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.441
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,883,030
Number of Sequences: 37866
Number of extensions: 1925805
Number of successful extensions: 7236
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 128
Number of HSP's successfully gapped in prelim test: 99
Number of HSP's that attempted gapping in prelim test: 4996
Number of HSP's gapped (non-prelim): 1298
length of query: 840
length of database: 18,247,518
effective HSP length: 111
effective length of query: 729
effective length of database: 14,044,392
effective search space: 10238361768
effective search space used: 10238361768
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.