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Search of human proteins with 208022632
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
(1870 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 3595 0.0
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 3518 0.0
gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 1591 0.0
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 522 e-147
gi|71061468 centromere protein E [Homo sapiens] 211 5e-54
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 206 2e-52
gi|55770834 centromere protein F [Homo sapiens] 202 2e-51
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 197 1e-49
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 197 1e-49
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 197 1e-49
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 197 1e-49
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 194 7e-49
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 194 9e-49
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 191 4e-48
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 187 8e-47
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 186 2e-46
gi|21735548 centrosomal protein 2 [Homo sapiens] 184 9e-46
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 180 1e-44
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 180 1e-44
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 179 3e-44
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 179 3e-44
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 179 3e-44
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 179 3e-44
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 179 3e-44
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 179 3e-44
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 179 3e-44
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 179 3e-44
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 179 3e-44
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 178 4e-44
gi|148746195 trichohyalin [Homo sapiens] 177 9e-44
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 3595 bits (9322), Expect = 0.0
Identities = 1870/1870 (100%), Positives = 1870/1870 (100%)
Query: 1 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE 60
MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
Sbjct: 1 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE 60
Query: 61 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE 120
SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
Sbjct: 61 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE 120
Query: 121 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD 180
VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
Sbjct: 121 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD 180
Query: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240
MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
Sbjct: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240
Query: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK 420
TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK 420
Query: 421 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
Sbjct: 421 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
Query: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL 960
IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL 960
Query: 961 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1020
ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP
Sbjct: 961 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1020
Query: 1021 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1080
PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA
Sbjct: 1021 PISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQA 1080
Query: 1081 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES 1140
QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES
Sbjct: 1081 QILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES 1140
Query: 1141 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1200
VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR
Sbjct: 1141 VIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDR 1200
Query: 1201 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1260
YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET
Sbjct: 1201 YNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1260
Query: 1261 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE 1320
EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE
Sbjct: 1261 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLE 1320
Query: 1321 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY 1380
EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY
Sbjct: 1321 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY 1380
Query: 1381 KFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQD 1440
KFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQD
Sbjct: 1381 KFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQD 1440
Query: 1441 SSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVL 1500
SSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVL
Sbjct: 1441 SSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVL 1500
Query: 1501 AGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTS 1560
AGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTS
Sbjct: 1501 AGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTS 1560
Query: 1561 FEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSH 1620
FEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSH
Sbjct: 1561 FEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQSH 1620
Query: 1621 SSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVV 1680
SSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVV
Sbjct: 1621 SSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVV 1680
Query: 1681 TLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPG 1740
TLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPG
Sbjct: 1681 TLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPG 1740
Query: 1741 DFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYAT 1800
DFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYAT
Sbjct: 1741 DFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYAT 1800
Query: 1801 LPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRNS 1860
LPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRNS
Sbjct: 1801 LPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRNS 1860
Query: 1861 KSRSREQQSS 1870
KSRSREQQSS
Sbjct: 1861 KSRSREQQSS 1870
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 3518 bits (9121), Expect = 0.0
Identities = 1841/1871 (98%), Positives = 1842/1871 (98%), Gaps = 29/1871 (1%)
Query: 1 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE 60
MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE
Sbjct: 1 MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLE 60
Query: 61 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE 120
SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE
Sbjct: 61 SQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEE 120
Query: 121 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD 180
VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD
Sbjct: 121 VKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD 180
Query: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240
MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM
Sbjct: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240
Query: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS
Sbjct: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
Query: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK
Sbjct: 301 DARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETK 360
Query: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK 420
TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK
Sbjct: 361 TMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQK 420
Query: 421 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR
Sbjct: 421 QSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
Query: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK
Sbjct: 481 TTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK 540
Query: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS
Sbjct: 541 TIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETS 600
Query: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA
Sbjct: 601 SKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA 660
Query: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM
Sbjct: 661 LEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKM 720
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ
Sbjct: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ 780
Query: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR
Sbjct: 781 QLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR 840
Query: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID
Sbjct: 841 LRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATID 900
Query: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD-RYKLLESK 959
IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD RYKLLESK
Sbjct: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESK 960
Query: 960 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1019
LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS
Sbjct: 961 LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS 1020
Query: 1020 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1079
PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ
Sbjct: 1021 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
Query: 1080 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1139
AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE
Sbjct: 1081 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE 1140
Query: 1140 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1199
SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED
Sbjct: 1141 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1200
Query: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1259
RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE
Sbjct: 1201 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKE 1260
Query: 1260 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL 1319
TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL
Sbjct: 1261 TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNL 1320
Query: 1320 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ
Sbjct: 1321 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1380
Query: 1380 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ 1439
YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ
Sbjct: 1381 YKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQ 1440
Query: 1440 DSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMV 1499
DSSSVGSNSLEDGQTLGTKKSS +MNDLVQSMV
Sbjct: 1441 DSSSVGSNSLEDGQTLGTKKSS----------------------------TMNDLVQSMV 1472
Query: 1500 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT 1559
LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT
Sbjct: 1473 LAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTT 1532
Query: 1560 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS 1619
SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS
Sbjct: 1533 SFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNNQSRPQS 1592
Query: 1620 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV 1679
HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV
Sbjct: 1593 HSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEV 1652
Query: 1680 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP 1739
VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP
Sbjct: 1653 VTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTP 1712
Query: 1740 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA 1799
GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA
Sbjct: 1713 GDFYDRRTTKPEFLRPGPRKTEDTYFISSAGKPTPGTQGKIKLVKESSLSRQSKDSNPYA 1772
Query: 1800 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN 1859
TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN
Sbjct: 1773 TLPRASSVISTAEGTTRRTSIHDFLTKDSRLPISVDSPPAAADSNTTAASNVDKVQESRN 1832
Query: 1860 SKSRSREQQSS 1870
SKSRSREQQSS
Sbjct: 1833 SKSRSREQQSS 1843
>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
Length = 2028
Score = 1591 bits (4120), Expect = 0.0
Identities = 879/1795 (48%), Positives = 1235/1795 (68%), Gaps = 85/1795 (4%)
Query: 9 LLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKLESQRVNKKV 68
LLE F+ SPLVTWVKTFGP +G+ NL Y+ LVDG+FLNQ+MLQI+P+ +QR+NK V
Sbjct: 8 LLELFLQSPLVTWVKTFGPFGSGSQDNLTMYMDLVDGIFLNQIMLQIDPRPTNQRINKHV 67
Query: 69 NNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLL 128
NND +LR+ NL+ILVR IK YYQE LQQLI+M+LPNVL+IG++P S + EE+KK+LLL+
Sbjct: 68 NNDVNLRIQNLTILVRNIKTYYQEVLQQLIVMNLPNVLMIGRDPLSGKSMEEIKKVLLLV 127
Query: 129 LGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEP 188
LGCAVQC++KEEFIERI+ LD +T+A + AHIQEVTHNQENVFDLQW+E+ D++ E++E
Sbjct: 128 LGCAVQCERKEEFIERIKQLDIETQAGIVAHIQEVTHNQENVFDLQWLELPDVAPEELEA 187
Query: 189 LLKNMALHLKRLIDERDEHSETIIELSEERDGLHFL----PHASSSAQSPCGSPGMKRTE 244
L ++M LHL+RLID+RDE +E I++L++ERD L P SSSA S +E
Sbjct: 188 LSRSMVLHLRRLIDQRDECTELIVDLTQERDYLQAQHPPSPIKSSSADSTPSPTSSLSSE 247
Query: 245 SRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS 304
+QHL+VELAD KA++RR+RQELE+KTEQL+D + E++Q+ +EL++++QEN+ L +DARS
Sbjct: 248 DKQHLAVELADTKARLRRVRQELEDKTEQLVDTRHEVDQLVLELQKVKQENIQLAADARS 307
Query: 305 ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
AR YRDELD+LREKA RV++LE E++R KE+LHD++FYKAR+EEL+EDN +L+ETK MLE
Sbjct: 308 ARAYRDELDSLREKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAMLE 367
Query: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
+QL RAR DK+HELEKENLQLK+KLHD+E++RD D+K+IEEL+EENM LE+AQKQSM+
Sbjct: 368 EQLTAARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMN 427
Query: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
ES HLGWELEQ+S+ ++LS+A +KS E+NE SSR+LKLE ENQSL T++ LR
Sbjct: 428 ESAHLGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQGLRDASL 487
Query: 485 SVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
+E + K ++EKEN +LSKK+E L+ ++ +EKQS Q+ + LS++L++EK QL+ +ET
Sbjct: 488 VLEESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMET 547
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
L+ + RQIK LEQE +HLN+ + SLR+RSQ+S+EAR+KD+EKENK LH+++ E + KLS
Sbjct: 548 LKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLS 607
Query: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
++EFEKRQ+ ++LE KEKGERAE+LE EL L++EN L +K+T+L+ EK+EALE E
Sbjct: 608 QLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSLETATEKVEALEHE 667
Query: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
+ L+ ENR L+K+LD+ +N++ QLE LE++N QLD ENLELRR VE+++ S K+AQ++
Sbjct: 668 SQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLELRRLVETMRFTSTKLAQME 727
Query: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
EN++LE EKE+L+K ++LLKA KK+ERLE+SYQ + EN RLQ++LE+S+ K Q LES
Sbjct: 728 RENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLESSSHKTQTLES 787
Query: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
EL +LE E Q L+++LE L++++ +LE EK+ K+LEQE +QLEKDKK LEKE KRL QQ
Sbjct: 788 ELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQ 847
Query: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
E+KD L+++ K+ +EKE++ L KE+ +++ +LKELEK+N++L K+ T+ +TL
Sbjct: 848 VELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLKELEKDNRDLTKQVTVHARTL 907
Query: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLL-HDEQSTDDRYKLLESKLEST 963
TLREDLV EKLK+QQ++++L+KL+ ELEK+GLN+E LL D+ +D +YK+LE + ES
Sbjct: 908 TTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQEDDSGSDTKYKILEGRNESA 967
Query: 964 LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSS---- 1019
LK +L +KEEKI LEA++EE + N+QL EL+ +KK E L+Q Q E + +Q+S
Sbjct: 968 LKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKECETLRQNQGEGQHLQNSFKHP 1027
Query: 1020 --PPISGEDNK--WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1075
+ K W +E T ELL+VKDR IE+ERNNA LQAEKQ LK QL+ LETQN
Sbjct: 1028 AGKTAASHQGKEAWGPGHKEATMELLRVKDRAIELERNNAALQAEKQLLKEQLQHLETQN 1087
Query: 1076 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1135
+QIL LQ+Q+ LQE NTTLQTQ AKLQVENSTL+SQS +L Q L ++ E
Sbjct: 1088 VTFSSQILTLQKQSAFLQEHNTTLQTQTAKLQVENSTLSSQSAALTAQYTLLQNHHTAKE 1147
Query: 1136 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1195
ENES+ +++E L + Y++L++DHE L LHERQ++EYE+LI +H LK+ H+NLE+EH+
Sbjct: 1148 TENESLQRQQEQLTAAYEALLQDHEHLGTLHERQSAEYEALIRQHSCLKTLHRNLELEHK 1207
Query: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255
+L +R+ +LK+K +LE+ EK+L E+E + E + + E ++L GE DR+N + Q
Sbjct: 1208 ELGERHGDMLKRKAELEEREKVLTTEREALQQEQRTNALAMGENQRLRGELDRVNFLHHQ 1267
Query: 1256 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1315
L E E L K LK+ LNN++LE R +A F +LKEQ+Q +DI+ TKL+N CELLS+L
Sbjct: 1268 LKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISLTKLDNHCELLSRL 1327
Query: 1316 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
KGNLEEEN HLL QIQ L QN+ LLEQNME+K+ +H EQ+QYIDKLN LRR KEKLEEK
Sbjct: 1328 KGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQYIDKLNALRRHKEKLEEK 1387
Query: 1376 IMDQYKFYDPSPPRRRGNWITLK-MRKLIKSKKDINRERQKSLTLTP----TRSDSSEGF 1430
IMDQYKFYDP PP+++ +WI K + KLIK KK+ +RER KS +P SD +
Sbjct: 1388 IMDQYKFYDP-PPKKKNHWIGAKALVKLIKPKKEGSRERLKSTVDSPPWQLESSDPASPA 1446
Query: 1431 LQLP---HQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKD-KDKMKACYR 1486
P ++ D+ ++GSN E+ + P D K K + +R
Sbjct: 1447 ASQPLRSQAENPDTPALGSNCAEERDAHNGS------------VGKGPGDLKPKRGSPHR 1494
Query: 1487 RSMSMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAG 1546
GS + + D++ ELG+ ST+A + NS+
Sbjct: 1495 -------------------GSLDRTDASTDLAMRSWPSELGSRTCSTSATTTAPSNSTPI 1535
Query: 1547 FRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEV 1606
R K S +++ + + R + SRP+SL+S R N+++N+S +
Sbjct: 1536 ARHPG--RTKGYNSDDNLCEPSL-EFEVPNHRQYVSRPSSLESSR----NTSSNSSPLNL 1588
Query: 1607 KAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQ-----TRSSPVLQHKISE 1661
K + R +S SS + D S+P + + R+ P+ Q +
Sbjct: 1589 KGSSEQLHGRSESFSSEDLIPSRDLATLPREASTPGRNALGRHEYPLPRNGPLPQEGAQK 1648
Query: 1662 TLESRHH---KIKTGSPGSEVVTLQQFLEESNKLTSVQIKSSSQENLLDEVMKSLSVSSD 1718
+ + + + SP SE+VTL++FLEESN+ + S +++LL + + S
Sbjct: 1649 RGTAPPYVGVRPCSASPSSEMVTLEEFLEESNRSSPTHDTPSCRDDLLSDYFRKASDPPA 1708
Query: 1719 FLGKDKPVSCGLARSVSGKTPGDFY-----------DRRTTKP-EFLRPGPRKTE 1761
G+ P A+ K P +F + R KP ++++P R TE
Sbjct: 1709 IGGQPGPP----AKKEGAKMPTNFVAPTVKMAAPTSEGRPLKPGQYVKPNFRLTE 1759
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 522 bits (1345), Expect = e-147
Identities = 418/1439 (29%), Positives = 716/1439 (49%), Gaps = 154/1439 (10%)
Query: 8 PLLEQFMTSPLVTWVKTFGPLAA----GNGTNLDE-----------YVALVDGVFLNQVM 52
P L F++ L TW L G +E ++ L DG L +V+
Sbjct: 7 PRLRDFLSGSLATWALGLAGLVGEAEDSEGEEEEEEEEPPLWLEKRFLRLSDGALLLRVL 66
Query: 53 LQINPKLES-QRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKN 111
I P R+ + ++ A+ R+ NL+ L +++ +YQE LQ LI+ P++ +G +
Sbjct: 67 GIIAPSSRGGPRMLRGLDGPAAWRVWNLNHLWGRLRDFYQEELQLLILSPPPDLQTLGFD 126
Query: 112 PFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENV- 170
P SE+ E+++ +L LLLG +VQC+ +E FI IQGL + ++ +AA IQEVT V
Sbjct: 127 PLSEEAVEQLEGVLRLLLGASVQCEHRELFIRHIQGLSLEVQSELAAAIQEVTQPGAGVV 186
Query: 171 FDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSS 230
L + +++ ++E L +++ L +L ERD ++ + EL ER+ L P A S
Sbjct: 187 LALSGPDPGELAPAELEMLSRSLMGTLSKLARERDLGAQRLAELLLEREPLCLRPEAPSR 246
Query: 231 AQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKR 290
A P P HL+++LA+AKA++RRLRQELEEK E LLD + E++ +E E++R
Sbjct: 247 A--PAEGPS-------HHLALQLANAKAQLRRLRQELEEKAELLLDSQAEVQGLEAEIRR 297
Query: 291 LQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK 350
L+QE L A+ A +YR+E +ALRE+A R+ +L+ E+ R +ERL E YK+++EE +
Sbjct: 298 LRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYKSQLEEER 357
Query: 351 EDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME 410
+ VL +K +LE+QLE R R +LHE ++ENL L+ +L + E D R ++++L E
Sbjct: 358 VLSGVLEASKALLEEQLEAARERCARLHETQRENLLLRTRLGEAHAELDSLRHQVDQLAE 417
Query: 411 ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP----QKSLGHEVNELTSSRLLKLE 466
EN+ LE+ ++S++ EAP SL EV E + RL LE
Sbjct: 418 ENVELELELQRSLEPP------------PGSPGEAPLAGAAPSLQDEVREAEAGRLRTLE 465
Query: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526
EN+ L ++ L+ G +L+ +E+ L E + + + S Q
Sbjct: 466 RENRELRGLLQVLQ----GQPGGQHPLLEAPREDPVLPVLEEAPQTPVAFD-HSPQGLVQ 520
Query: 527 LSKDLMKEKAQL-EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS------AE 579
++D + L ++++ E S + + + + + + Q S +
Sbjct: 521 KARDGGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESG 580
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIK-KELEHYKEKGERAE--ELENELHH 636
+ V+ E K S ++ + ++ + +I+ +L + +G A EL E
Sbjct: 581 SPVETQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWG 640
Query: 637 LEKENELLQKKITNLKITCEKIEALEQENSEL-----ERENRKLKKTLDSFKNLTFQLES 691
L +E + K + + ++E E N L + E R+ + L+ +
Sbjct: 641 LRQEGP--EHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKP 698
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
+K L+ + E ESL + L+ E +L + E L LE A +K
Sbjct: 699 QQKSEGALEVQVWEGPIPGESLASGVAEQEALREEVAQLRRKAEALGDELE---AQARKL 755
Query: 752 ERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE 811
E + E RL K L + + + E + E L+ E ++ + + LE
Sbjct: 756 E-------AQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARLR---EAVEAAGQELE 805
Query: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSK 871
+E ++L + + ++++Q E+E RLR Q+E + ++ LE E +
Sbjct: 806 SASQEREALVEALAAAGRERRQWEREGSRLRAQSEAAEERMQV-------LESEGRQ--- 855
Query: 872 EIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHE 931
L+E E+E +E K A L+ +L ++ +++ LE L E
Sbjct: 856 ----------HLEEAERERRE--KEA---------LQAELEKAVVRGKELGARLEHLQRE 894
Query: 932 LEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQ 991
LE+ L ++ L +++S RY+ LE +LE+ L+ + KEE + L+ R Q
Sbjct: 895 LEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRA-------LQ 947
Query: 992 LRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVE 1051
L +EL +++ L ++ E + + + RLIEVE
Sbjct: 948 LEEELFQLRQGPAGLGPKKRAEPQLVETQNV-----------------------RLIEVE 984
Query: 1052 RNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENS 1111
R+NA L AEK AL+ QL+ LE Q +LQ + L Q+ QE ++ LQ + + L+++
Sbjct: 985 RSNAMLVAEKAALQGQLQHLEGQLGSLQGRAQELLLQSQRAQEHSSRLQAEKSVLEIQGQ 1044
Query: 1112 TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQAS 1171
L+ + LE E + + +E+ + +L++DH+ L L RQ +
Sbjct: 1045 ELHR--------------KLEVLEEEVRAARQSQEETRGQQQALLRDHKALAQLQRRQEA 1090
Query: 1172 EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKN 1231
E E L+ +H LK+ + LE+ HR+L+ R+ QL Q+ +E E L E+E+++ +
Sbjct: 1091 ELEGLLVRHRDLKANMRALELAHRELQGRHEQLQAQRASVEAQEVALLAERERLMQDGHR 1150
Query: 1232 HETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKL 1291
+ E ++L E+DR ++L +E LQ + L+ L +LE+ +LE + +L
Sbjct: 1151 QRGLEEELRRLQSEHDRAQMLLAELSRERGELQGERGELRGRLARLELERAQLEMQSQQL 1210
Query: 1292 KEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLF 1351
+E QQLD+++ +L QCELL+QL+ EEENR LL ++Q L +NR LLE+++ES+D
Sbjct: 1211 RESNQQLDLSACRLTTQCELLTQLRSAQEEENRQLLAEVQALSRENRELLERSLESRDHL 1270
Query: 1352 HVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSP-PR-RRGNWITLKMRKLIKSKKD 1408
H EQR+Y+D+LN LRR+K+KL EKIMDQY+ +P P PR ++G+W+ K+++L++ +++
Sbjct: 1271 HREQREYLDQLNALRREKQKLVEKIMDQYRVLEPVPLPRTKKGSWLADKVKRLMRPRRE 1329
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 211 bits (537), Expect = 5e-54
Identities = 272/1269 (21%), Positives = 563/1269 (44%), Gaps = 159/1269 (12%)
Query: 237 SPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRL----- 291
S ++ E + L+ + I+ + +LE K + +D ++EL+ E+ +L
Sbjct: 646 SENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLID 705
Query: 292 ----QQENMNLLSDARSARMYR------DELDALREKAVRVDKLESEVSRYKERLHDIEF 341
+ NL + + + + +E +ALRE+ + + +L+S S ++E
Sbjct: 706 GKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPS-------EVER 758
Query: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401
+ +++ E+ ++ K L ++ +R L E E + K L +
Sbjct: 759 LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE---EIGKTKDDLATTQSNYKST 815
Query: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR 461
++ + +M E K ++E+ + E+ +S+ ++ ++ SLG EL S +
Sbjct: 816 DQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDS---SLGALKTEL-SYK 871
Query: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521
+L+ + + + + + E+ + +E S + +E+E +++K++ E+ Q
Sbjct: 872 TQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEK 931
Query: 522 QNCQNLSKDLMKEKAQLEKTI-ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
+ + L + L E+ QL+ I +T+ N + Q E L + SL+Q +
Sbjct: 932 DDLKQLQESLQIERDQLKSDIHDTVNMNIDTQ--------EQLRNALESLKQHQETINTL 983
Query: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQI----KKELEHYKEKGERAEELENE--- 633
+ K E+ ++ LH E ++ +K EF+++ + K++LE + A+ +NE
Sbjct: 984 KSKISEEVSRNLH---MEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIE 1040
Query: 634 ----LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQL 689
+ L +E LQ+ + ++ E+++ +EN E+ EN++ + L L Q
Sbjct: 1041 QQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGD--ELKKQQ 1098
Query: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
E + +E + ++ EL R + L K+ + ++++L+ +++QL E + K
Sbjct: 1099 EIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKE---KSQQLQEKQQQLLNVQEEMSEMQK 1155
Query: 750 KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKR 809
K +E L+ L+N ++ +E+E +L Q L +N EE+K +K
Sbjct: 1156 KINEIE-----------NLKNELKNKELTLEHMETERLELA---QKLNENYEEVKSITKE 1201
Query: 810 LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
+ L++ KS E E L +++E + +++ +I L+E+ I L +
Sbjct: 1202 RKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEK 1261
Query: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDL--VSEKLKTQQMNNDLEK 927
+ +I + ++LEK + +L + +I L +E L V E +TQ+ N+LE
Sbjct: 1262 TAQI-------INTQDLEKSHTKLQE----EIPVLHEEQELLPNVKEVSETQETMNELEL 1310
Query: 928 LTHE--------LEKIGLNKERLLHDEQSTDDRYKLLESKLES--TLKKSLEIK----EE 973
LT + L +I + + RL Q + + K L + ++ T+K++LE+K +E
Sbjct: 1311 LTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKE 1370
Query: 974 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGED------N 1027
I A+++ES + + Q L +K+ E K + E+ + + +
Sbjct: 1371 HIRETLAKIQESQSKQE---QSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLS 1427
Query: 1028 KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQ-----LETQNN------ 1076
K +ES + + + K KD +++R LQ+E LK +K+ LET+
Sbjct: 1428 KRLQESHDEMKSVAKEKD---DLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC 1484
Query: 1077 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1136
L+ Q + V+L E+ T + T +L+ N L ++ + + Q I+Q S
Sbjct: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
Query: 1137 ENESVIKEREDLKSLYDSLIKDHEK--LELLHERQAS--EYESLISKHGTLKSAHKNLEV 1192
E + +K+ ++ + DS ++ E LEL + Q S E + +I + +K + L++
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI 1604
Query: 1193 EH--------------RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAE 1238
E ++ +++ Q LK E EKM ++E K + ET
Sbjct: 1605 ERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLK-----EQFETQKLN 1659
Query: 1239 YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAE----FSKLKEQ 1294
+ + EN RL + L+E + + +L+S+ K+E+ +L+ ++ E+
Sbjct: 1660 LENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEK 1719
Query: 1295 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV- 1353
++L I L E + +L+G + E+ + + + L N L Q+++ ++ +
Sbjct: 1720 QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIA 1779
Query: 1354 -----EQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKM--RKLIKSK 1406
EQ++ IDKL + +K +K+ + K + S + + LK +LI K
Sbjct: 1780 HMHLKEQQETIDKLRGIVSEK---TDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLK 1836
Query: 1407 KDINRERQK 1415
KD+N ++K
Sbjct: 1837 KDVNETQKK 1845
Score = 203 bits (517), Expect = 1e-51
Identities = 275/1304 (21%), Positives = 560/1304 (42%), Gaps = 175/1304 (13%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
TD ++ + L + K +++E + ++ I+ LS+E A + S
Sbjct: 815 TDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELS----- 869
Query: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQE-------LEQMEIELKRL 291
+T+ Q + E+ + ++ +L+++LE + L ++E L+Q E+K L
Sbjct: 870 --YKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTL 927
Query: 292 QQENMNLLSDARSARMYRDEL-----DALREKAVRVDKLESEVSRYKERLHDIEFYKARV 346
QE +L S ++ RD+L D + ++L + + K+ I K+++
Sbjct: 928 TQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKI 987
Query: 347 EELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-LKAKLHDMEMERDMDRKKI 405
E N + E +D+ + DK +LE +N Q L A + D E+ ++KI
Sbjct: 988 SEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIE--QQRKI 1045
Query: 406 EELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKL 465
L++E L+ + + E L +L++ +++
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKE--------------------------NIEM 1079
Query: 466 EMENQSLTKTV-EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
+ENQ + + +EL+ + V + +K E E R ++ +E ++ ++ Q LQ
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 525 QNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
Q ++ +E ++++K I + EN + ++K E EH+ L Q+ + E VK
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEI-ENLKNELKNKELTLEHMETERLELAQKLNENYE-EVKS 1197
Query: 585 IEKENKILHESIKETSSK-------LSKIEFEKRQIKKELE----HYKEKGERAEE---- 629
I KE K+L E K ++ + +IE Q K+EL+ H KE E +E
Sbjct: 1198 ITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRS 1257
Query: 630 --------------------LENELHHLEKENELLQ--KKITNLKITCEKIEALEQENS- 666
L+ E+ L +E ELL K+++ + T ++E L ++++
Sbjct: 1258 VSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTT 1317
Query: 667 ---------ELE--RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKC 715
E+E R N K +++ + K+LT + ++L+ L+ ++ +L+ ++
Sbjct: 1318 KDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLA 1377
Query: 716 ---ASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
S + L KE ++E ++ +E K R+E+ G L K L
Sbjct: 1378 KIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLG-------LSKRL 1430
Query: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL--EQLEKEN---------KSLE 821
+ S+ +++ + E DL+ + LQ ++LK + K + + LE E K E
Sbjct: 1431 QESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQE 1490
Query: 822 QETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV 881
+ ++L + + E E +++Q E + L+ +I EKE + K+I +E
Sbjct: 1491 ETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEI--YEKEEQFNIKQISEVQEKVN 1548
Query: 882 RLKELEKENKELVKRATIDIKT-LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKE 940
LK+ KE+++ A I++ ++ L L + + Q M + E++ E + + ++
Sbjct: 1549 ELKQF-KEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERD 1607
Query: 941 RLLHD--------EQSTDDRYKLLE-SKLESTLKKSLEIK--EEKIAALEARLEESTNYN 989
+L + ++S + Y+ L+ + + T +K EI+ +E+ + LE N
Sbjct: 1608 QLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLENIETEN 1667
Query: 990 QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLK------- 1042
+L Q L + ++ + +D+ R V+ + + + K E + TR+L K
Sbjct: 1668 IRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLK-ENLRETITRDLEKQEELKIV 1726
Query: 1043 ---VKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT----VSLQEQ 1095
+K+ +++ + + + K LE N+ L+AQ L +Q + + L+EQ
Sbjct: 1727 HMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQ 1786
Query: 1096 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1155
T+ + + L++ L N NA+L + L+ +I ++D+ +
Sbjct: 1787 QETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKV 1846
Query: 1156 IKDHEKLELLHERQASEYESLISKHGTLKSAHKNLE-----VEHRDLEDRYNQLLK-QKG 1209
+ + + + ++ + + I + H+NLE ++ RD R + LK ++
Sbjct: 1847 SEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERD 1906
Query: 1210 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1269
QL++ + K ++ E K ++ E+K+ D+L S+ + +Q D
Sbjct: 1907 QLKESLQETKARDLEIQQELKTARMLSKEHKETV---DKLREKISEKTIQISDIQKDLDK 1963
Query: 1270 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQ 1329
K L E + E + ++KE ++++ K+N + QLK E +N
Sbjct: 1964 SKDELQKKIQELQKKELQLLRVKE---DVNMSHKKINE----MEQLKKQFEAQNL----S 2012
Query: 1330 IQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE 1373
+Q++ + N L ++ ES + E R + +ELRR KE L+
Sbjct: 2013 MQSVRMDNFQLTKKLHESLE----EIRIVAKERDELRRIKESLK 2052
Score = 196 bits (497), Expect = 2e-49
Identities = 311/1445 (21%), Positives = 603/1445 (41%), Gaps = 250/1445 (17%)
Query: 159 HIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEER 218
+++EV+ QE + +L+ + T+ S L + + RL ++ E E I L++ER
Sbjct: 1294 NVKEVSETQETMNELELL--TEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKER 1351
Query: 219 DGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQEL--EEKTEQLLD 276
D L + A +K + ++H+ LA + + Q L +EK +
Sbjct: 1352 DNLKTIKEALE----------VKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTK 1401
Query: 277 CKQELEQ----------MEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLE 326
E+EQ +EIE+ L + + +S +D+L L+E L+
Sbjct: 1402 IVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEV------LQ 1455
Query: 327 SEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ 386
SE + KE + +I V + E + L L++Q E L E E E
Sbjct: 1456 SESDQLKENIKEI------VAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEIST 1509
Query: 387 LKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAP 446
++ +L E D + KI+E+ E+ + Q + E ++ EL+Q + ++
Sbjct: 1510 IQKQL---EAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVN---ELKQFKEHRKAKDSA 1563
Query: 447 QKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTV-------DSVEGNASKILKMEKE 499
+S+ ++ ELT+ RL + + E Q + K EE++ D ++ N +I+ KE
Sbjct: 1564 LQSIESKMLELTN-RLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKE 1622
Query: 500 NQRLSKKVEILENEIVQEKQS-LQNCQNLSKDLMKEKAQLEKTIET--------LRENSE 550
+Q K+ + L+ V E Q + ++L + +K LE IET L EN E
Sbjct: 1623 SQE--KEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLNLEN-IETENIRLTQILHENLE 1679
Query: 551 RQIKILEQENEHLNQTVSSLR-QRSQISAEAR---VKDIEKEN--KILHESIKE---TSS 601
+++ + +E + L +L+ +R Q+ R +D+EK+ KI+H +KE T
Sbjct: 1680 -EMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETID 1738
Query: 602 KLSKIEFEKRQ----IKKELEHYKEKGERAE-ELENELH----HLEKENELLQKKITNLK 652
KL I EK ++K+LEH + + + +++ EL HL+++ E + K
Sbjct: 1739 KLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKL---RG 1795
Query: 653 ITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVES 712
I EK + L +LE N KL++ + K QL +L+K+ ++ ++ E+ + +
Sbjct: 1796 IVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQ 1855
Query: 713 LKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL 772
+K S+ +++L++EN L ++L + LE +K+ K+ + L + L +E +L+++L
Sbjct: 1856 IKDQSLTLSKLEIENLNLA---QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESL 1912
Query: 773 ENSNKKIQQLESELQ--------------------------------DLEMENQTLQKNL 800
+ + + +++ EL+ DL+ LQK +
Sbjct: 1913 QETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKI 1972
Query: 801 EELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKEN--------------KRLRQQAE 846
+EL+ +L +++++ ++ +++E+ KKQ E +N K+L + E
Sbjct: 1973 QELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLE 2032
Query: 847 --------------IKDTTLEENNVKIGNL------EKENKTLSKEIGIY---------- 876
IK++ E + I L +++N + E +
Sbjct: 2033 EIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTES 2092
Query: 877 -KESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKI 935
+E C R+KEL K E+ + + L +++ +K + ++ +L + + I
Sbjct: 2093 LREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHI 2152
Query: 936 GLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA----------RLEES 985
E+L Q + + KL+ L +IKEE+ ++ + +E
Sbjct: 2153 ----EKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKEL 2208
Query: 986 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDN--KWERESQETTRELLKV 1043
Q L+Q+ + LK Q+ + ++ E + E Q+ ++
Sbjct: 2209 LIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEM 2268
Query: 1044 KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTT----- 1098
L E ++ K ++ + ++ NN +I+A+ ++ +E++ T
Sbjct: 2269 TQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEW 2328
Query: 1099 ------LQTQNAKLQVENSTLNSQ--------STSLMNQNAQLLIQQSSLENEN-----E 1139
L+ +N KL TL + T+ N+N + + + L E
Sbjct: 2329 EQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELEN 2388
Query: 1140 SVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLED 1199
S+ + +E +IK ++LE+ ++ A + + L+ + ++V L+D
Sbjct: 2389 SLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQV----LQD 2444
Query: 1200 RYNQLLKQ-KGQLEDLE-KMLKVEQEKMLLENKNHETVAA-----EYKKLCGENDRLNHT 1252
+ K K ++EDL+ K++K++ EKM + + ++A EY+K R N
Sbjct: 2445 KVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLR 2504
Query: 1253 YSQLLKETEVL------QTDHKNL-----KSLLNNSKL-----EQTRLEAEFSKLKEQYQ 1296
SQ ++T V+ Q +K L ++ N+K E RLE E SKLK+Q +
Sbjct: 2505 RSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNE 2564
Query: 1297 QLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQR 1356
QL + + ELLS N+HL ++++T + RTL E+ E
Sbjct: 2565 QL------IKQKNELLS--------NNQHLSNEVKT--WKERTL---KREAHKQVTCENS 2605
Query: 1357 QYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKS 1416
K+ +K+++ + DP P + K + S + S
Sbjct: 2606 PKSPKVTGTASKKKQITPSQCKERNLQDPVPKESPKSCFFDSRSKSLPSPHPVRYFDNSS 2665
Query: 1417 LTLTP 1421
L L P
Sbjct: 2666 LGLCP 2670
Score = 179 bits (453), Expect = 3e-44
Identities = 267/1317 (20%), Positives = 583/1317 (44%), Gaps = 165/1317 (12%)
Query: 137 KKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQ-----EDIEPLLK 191
KKE + R + + + Q++ Q+ + ++Q E+++M + E+++ LK
Sbjct: 1110 KKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ-EEMSEMQKKINEIENLKNELK 1168
Query: 192 NMALHLKRLIDER-------DEHSETIIELSEERDGLHFLPHASSSAQS-------PCGS 237
N L L+ + ER +E+ E + +++ER L L + + + +
Sbjct: 1169 NKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEA 1228
Query: 238 PGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE------QMEIELKRL 291
G++ E + + L + + I LR+ + EKT Q+++ Q+LE Q EI +
Sbjct: 1229 TGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINT-QDLEKSHTKLQEEIPVLHE 1287
Query: 292 QQENMNLLSDARSARMYRDELDALREKAVRVD-----KLESEVSRYKERLHD----IEFY 342
+QE + + + + +EL+ L E++ D ++E E R E+ + I+
Sbjct: 1288 EQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSL 1347
Query: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHD---MEMERD 399
+ LK + L L++ + T A+ + ++++L +K K ++ + E +
Sbjct: 1348 TKERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEME 1407
Query: 400 MDRKKIEELME---ENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456
+ K L+ E + L ++S DE + E + + R E+ ++ L + E
Sbjct: 1408 QFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKE 1467
Query: 457 LTSSRLL---KLEMENQSLTK---TVEELRTTVDSVEGNASKILK-MEKENQRLSKKVEI 509
+ + L +L++ + L + T+ ELR + E S I K +E N +L K++
Sbjct: 1468 IVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE 1527
Query: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSS 569
+ EK+ N + +S+ ++EK K + R+ + ++ +E + L +
Sbjct: 1528 -----IYEKEEQFNIKQISE--VQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQE 1580
Query: 570 LRQRSQISAEAR--VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG-ER 626
++ QI + + +K +++ +I + +KE + ++ + K +KE + K
Sbjct: 1581 SQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEI--VAKMKESQEKEYQFLKMTAVNE 1638
Query: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT 686
+E E+ HL+++ E + + N++ ++ + EN E E R + K D +++
Sbjct: 1639 TQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLE---EMRSVTKERDDLRSVE 1695
Query: 687 FQLESLEKENSQLDEENLE-LRRNVES---LKCASMKMAQLQL-----------ENKELE 731
E+L+ E QL E E + R++E LK M + + Q + E+
Sbjct: 1696 ---ETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEIS 1752
Query: 732 SEKEQLKKGLELLKAS-FKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE 790
+ ++ L+ + LKA K E L +++ L + + + K ++K +L + +DLE
Sbjct: 1753 NMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLE 1812
Query: 791 MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
N LQ+ ++ELK + +L L+K+ +++ S++E+ KKQ++ ++ L +
Sbjct: 1813 NSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTL--------S 1864
Query: 851 TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED 910
LE N+ + EN K + +++ R++E K ++ +K + + K R+
Sbjct: 1865 KLEIENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKA----RDL 1920
Query: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEI 970
+ ++LKT +M + K E + +E++ D K L+ + KK E+
Sbjct: 1921 EIQQELKTARMLSKEHK-----ETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQEL 1975
Query: 971 KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1030
+++++ L R++E N + + E++ +KK +EA + +QS + + K
Sbjct: 1976 QKKELQLL--RVKEDVNMSHKKINEMEQLKKQFEA------QNLSMQSVRMDNFQLTKKL 2027
Query: 1031 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQL---ETQNNNLQAQILAL-- 1085
ES E R + K +D E+ R +L+ E+ L+++ + QN+ ++ + L
Sbjct: 2028 HESLEEIRIVAKERD---ELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSD 2084
Query: 1086 --QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1143
Q T SL+E+ + ++ +L S ++ L N L + +E + E ++
Sbjct: 2085 GQQHLTESLREKCSRIK----ELLKRYSEMDDHYECL---NRLSLDLEKEIEFQKELSMR 2137
Query: 1144 EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203
+ +L SL K EKL ++R + E+ ++ K + S ++ E + +++
Sbjct: 2138 VKANL-SLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKF-- 2194
Query: 1204 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVL 1263
+++ + +VE++K LL H + S+ L++ ++
Sbjct: 2195 ---------EMDFIDEVEKQKELLIKIQHLQQDCDVP-------------SRELRDLKLN 2232
Query: 1264 QTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQL--------DITSTKLNNQCELLSQL 1315
Q +++ +L + E+EF +K ++QQ+ LN + + + +L
Sbjct: 2233 QNMDLHIEEILKDFS------ESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFD-IEKL 2285
Query: 1316 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL 1372
K +++EN + + ++ ++ E ++ +++ L L+ + EKL
Sbjct: 2286 KNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKL 2342
Score = 172 bits (436), Expect = 3e-42
Identities = 261/1276 (20%), Positives = 570/1276 (44%), Gaps = 204/1276 (15%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ----------------EN 295
E++ +A ++R R+E+ + +QL + E +E +L Q EN
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396
Query: 296 MNLLSDARSARMYRDELDALREKAV-----RVDKLESEVSRYKERLH-----DIEFYKAR 345
+ + S+ + EL A R++ V +++K+++ S Y ++ + + +K
Sbjct: 397 LTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKN--SNYADQFNIPTNITTKTHKLS 454
Query: 346 VEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELE---------KENLQLKAKLHDMEM 396
+ L+E ++ + + + L D L E+E +EN++ ++L+ +
Sbjct: 455 INLLREIDESVCSESDVFSNTL-------DTLSEIEWNPATKLLNQENIE--SELNSLRA 505
Query: 397 ERDMDRKKIEELM--EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEV 454
+ D E+L +E M L++ +K +DE E + R ++ + Q L HE+
Sbjct: 506 DYDNLVLDYEQLRTEKEEMELKLKEKNDLDE-------FEALERKTKKDQEMQ--LIHEI 556
Query: 455 NELTS----SRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQR--LSKKVE 508
+ L + + + ++EN+ L+ VE LR D ++ I + EN + LS +E
Sbjct: 557 SNLKNLVKHAEVYNQDLENE-LSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLE 615
Query: 509 ILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
+E+ Q KQ+L + + ++ D +E A L EN E + K+ E +
Sbjct: 616 SIEDP-KQMKQTLFDAETVALDAKRESAFLRS------ENLELKEKMKELATTYKQMEND 668
Query: 569 SLRQRSQISAEARVK-DIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA 627
+SQ+ A+ +++ D+EKE L + E + S I+ ++ K+L E +
Sbjct: 669 IQLYQSQLEAKKKMQVDLEKE---LQSAFNEITKLTSLID---GKVPKDLLCNLELEGKI 722
Query: 628 EELENELHHLEKENELLQKKI---TNLKITCEKIEALEQE----NSELERENRKLKKTLD 680
+L+ EL+ +ENE L++++ + LK ++E L +E + EL + K
Sbjct: 723 TDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFS 782
Query: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESL--KCASMKMAQLQLENKELESEKEQLK 738
+ +++ L +E + ++ + N +S + + K + E K +E +
Sbjct: 783 EVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENER 842
Query: 739 KGLELLKASFKKTERLEVSYQGLDIE----NQRLQKTLENSNKKIQQLESELQDLEMENQ 794
E++ S K+ ++ + S L E Q LQ+ +++ ++E + LE +
Sbjct: 843 MNQEIVNLS-KEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDS 901
Query: 795 TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT---- 850
TLQ E + +++L+Q +E K+L QE L++ ++ L+ E +L+ ++I DT
Sbjct: 902 TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLK--SDIHDTVNMN 959
Query: 851 --TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKE-----------LVKRA 897
T E+ + +L++ +T++ E R +E+ E + K+
Sbjct: 960 IDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQ 1019
Query: 898 TIDIKTLVTLREDLVSEKLKTQQ-----MNNDLEKLTHELEKIGLNKERLLHDEQ----- 947
++ K TL D+ ++ QQ + + +L LE + KE+L D +
Sbjct: 1020 DLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEM 1079
Query: 948 --STDDRYKLLESKLES-----------TLKKSLEIKE--EKIAALEARLEESTNYNQQL 992
+ +LL +L+ +KK E+ +++A +E +L+E + Q+
Sbjct: 1080 TIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEK 1139
Query: 993 RQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVER 1052
+Q+L V++ ++++ +E +++ ++ + E ET R L++ +L E
Sbjct: 1140 QQQLLNVQEEMSEMQKKINEIENLKNEL----KNKELTLEHMETER--LELAQKLNENYE 1193
Query: 1053 NNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENST 1112
++ E++ LK K ET+ ++L+ I ++ + +E+ L+ + L+ T
Sbjct: 1194 EVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEE---LKIAHIHLKEHQET 1250
Query: 1113 LNSQSTSLMNQNAQLL----IQQSSLENENE-SVIKEREDLKSLYDSLIKDHE---KLEL 1164
++ S+ + AQ++ +++S + + E V+ E ++L + + E +LEL
Sbjct: 1251 IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELEL 1310
Query: 1165 LHERQAS-------------------------EYESLISKHGTLKSAHKNLEVEHRDLED 1199
L E+ + E +SL + LK+ + LEV+H L++
Sbjct: 1311 LTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKE 1370
Query: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHET--VAAEYKKLCGENDRLNHTYSQLL 1257
+ L + +++ +++ + ++ K++ET + +E ++ ++ L ++L
Sbjct: 1371 HIRETLAK------IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEML 1424
Query: 1258 KETEVLQTDHKNLKSLL---NNSKLEQTRLEAEFSKLKEQY-----------QQLDITST 1303
++ LQ H +KS+ ++ + Q L++E +LKE ++L +
Sbjct: 1425 GLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHC 1484
Query: 1304 KLNNQCELLSQLKGNLEEENRH---LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYI- 1359
L Q E +++L+ NL E+ + Q++ + + + +++ E ++ F+++Q +
Sbjct: 1485 CLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQ 1544
Query: 1360 DKLNELRRQKEKLEEK 1375
+K+NEL++ KE + K
Sbjct: 1545 EKVNELKQFKEHRKAK 1560
Score = 146 bits (368), Expect = 2e-34
Identities = 220/1027 (21%), Positives = 436/1027 (42%), Gaps = 141/1027 (13%)
Query: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE 456
E D ++ +E M L+ ++ E+ E +Q+++ E + QK ++
Sbjct: 337 EVSTDEALLKRYRKEIMDLKKQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIEN 396
Query: 457 LTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQ 516
LT + + Q K + R T KI KM+ N + + I N +
Sbjct: 397 LTRMLVTSSSLTLQQELKAKRKRRVT-----WCLGKINKMKNSNY--ADQFNIPTNITTK 449
Query: 517 -EKQSLQNCQNLSKDLMKEKAQLEKTIETLRENS-ERQIKILEQENEHLNQTVSSLRQRS 574
K S+ + + + + E T++TL E K+L QEN + ++SLR
Sbjct: 450 THKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQEN--IESELNSLRA-- 505
Query: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENEL 634
+ V D E+ E + K EFE + K + + + L+N +
Sbjct: 506 --DYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLV 563
Query: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK------NLTFQ 688
H E N+ L+ ++++ K+E L ++ ++ +KL++ +DS K +L++
Sbjct: 564 KHAEVYNQDLENELSS------KVELLREKEDQI----KKLQEYIDSQKLENIKMDLSYS 613
Query: 689 LESLEK----ENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744
LES+E + + D E + L ES S + +L+ + KEL + +Q++ ++L
Sbjct: 614 LESIEDPKQMKQTLFDAETVALDAKRESAFLRSENL-ELKEKMKELATTYKQMENDIQLY 672
Query: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
++ + ++++V D+E + LQ K ++ ++ + N L+ + +L+
Sbjct: 673 QSQLEAKKKMQV-----DLEKE-LQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQ 726
Query: 805 ISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK 864
K L + +EN++L +E L + K L E +RLR++ + K EE ++ +
Sbjct: 727 ---KELNKEVEENEALREEVILLS-ELKSLPSEVERLRKEIQDKS---EELHI----ITS 775
Query: 865 ENKTLSKEIGIYKESCVR--LKELEKENKELV------KRATIDIKTLVTLREDLVSEKL 916
E L E+ ++KES V+ L+E+ K +L K + + TL D +K
Sbjct: 776 EKDKLFSEV-VHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDF-EQKY 833
Query: 917 K-----TQQMNNDLEKLTHELEK----IGLNKERLLHDEQSTDDRYKLLESKLEST--LK 965
K ++MN ++ L+ E +K +G K L + Q ++ + ++ +L LK
Sbjct: 834 KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLK 893
Query: 966 KSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGE 1025
+ LE ++ + +E T QQ +E+KT+ + + LKQ Q+ ++ +
Sbjct: 894 EQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH 953
Query: 1026 DN-KWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084
D ++QE R L+ ++++ T+ K + ++ + N
Sbjct: 954 DTVNMNIDTQEQLRNALE------SLKQHQETINTLKSKISEEVSRNLHMEENTGETKDE 1007
Query: 1085 LQRQTVSLQEQNT--TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1142
Q++ V + ++ TQ V+++ + Q + + L+ +++ L+ ESVI
Sbjct: 1008 FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFS----LIQEKNELQQMLESVI 1063
Query: 1143 KERE----DLKSLYDSLIKDHEKLELL-------HERQASEYESLISKHGTLKSAHKNLE 1191
E+E DLK + I++ E+L LL E A E I K G L L
Sbjct: 1064 AEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLA 1123
Query: 1192 VEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNH 1251
L+++ QL +++ QL L V++E ++ K
Sbjct: 1124 EVEEKLKEKSQQLQEKQQQL------LNVQEEMSEMQKK--------------------- 1156
Query: 1252 TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCEL 1311
+ E E L+ + KN + L + + E+ L KL E Y+++ + + ++
Sbjct: 1157 -----INEIENLKNELKNKELTLEHMETERLELA---QKLNENYEEVK----SITKERKV 1204
Query: 1312 LSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1371
L +L+ + E E HL I+ + Q E + H+ +++ + ++ELRR +
Sbjct: 1205 LKELQKSFETERDHLRGYIREIEATGL----QTKEELKIAHIHLKEHQETIDELRRSVSE 1260
Query: 1372 LEEKIMD 1378
+I++
Sbjct: 1261 KTAQIIN 1267
Score = 47.4 bits (111), Expect = 1e-04
Identities = 129/655 (19%), Positives = 253/655 (38%), Gaps = 92/655 (14%)
Query: 977 ALEARLEESTNYNQQLRQELKTVKK----------NYEALKQRQ---------DEERMVQ 1017
A RL+E N N+ L + +KK NY K + + R++
Sbjct: 247 AAGVRLKEGCNINRSLFILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIIC 306
Query: 1018 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN 1077
+ P+S ++ + T + +K + EV + A L+ ++ + KQLE +
Sbjct: 307 TITPVSFDETLTALQFASTAK-YMKNTPYVNEVSTDEALLKRYRKEIMDLKKQLEEVSLE 365
Query: 1078 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1137
+AQ + + L+E++ + QN K +EN T ++L+ SSL +
Sbjct: 366 TRAQAMEKDQLAQLLEEKDLLQKVQNEK--IENLT-------------RMLVTSSSLTLQ 410
Query: 1138 NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDL 1197
E K + + + K + + A ++ I + T K+ ++ +
Sbjct: 411 QELKAKRKRRVTWCLGKINK------MKNSNYADQFN--IPTNITTKTHKLSINLLREID 462
Query: 1198 EDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLL 1257
E ++ L+ L ++ K+L N E + +E L + D L Y QL
Sbjct: 463 ESVCSESDVFSNTLDTLSEIEWNPATKLL----NQENIESELNSLRADYDNLVLDYEQLR 518
Query: 1258 KETEVLQTDHKNLKSL-------LNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCE 1310
E E ++ K L K ++ +L E S LK + ++ + L N+
Sbjct: 519 TEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELS 578
Query: 1311 LLSQLKGNLEEENRHLLDQIQTLMLQNRTL--------LEQNMESKDLFHVEQRQYIDKL 1362
+L E++ + L + I + L+N + +E + K + +D
Sbjct: 579 SKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAK 638
Query: 1363 NE---LRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKK---DINRERQKS 1416
E LR + +L+EK+ + Y ++ N I L +L KK D+ +E Q +
Sbjct: 639 RESAFLRSENLELKEKMKELATTY-----KQMENDIQLYQSQLEAKKKMQVDLEKELQSA 693
Query: 1417 LTLTPTRSDSSEG--------FLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRL 1468
+ +G L+L + + D + +E+ + L + + LK L
Sbjct: 694 FNEITKLTSLIDGKVPKDLLCNLELEGKIT-DLQKELNKEVEENEALREEVILLSELKSL 752
Query: 1469 P--FLRNRPKDKDKMKACYRRSMSMNDLVQSMV-LAGQWTGSTENL-EVPDDISTGKRRK 1524
P R R + +DK + + + + L +V + G E + + DD++T +
Sbjct: 753 PSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY 812
Query: 1525 ELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFE--DISPQGVSDDSSTGS 1577
+ F NF T++ + K ++ + + E ++S + DSS G+
Sbjct: 813 KSTDQEFQ----NFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGA 863
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 206 bits (524), Expect = 2e-52
Identities = 248/1148 (21%), Positives = 494/1148 (43%), Gaps = 132/1148 (11%)
Query: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARS-ARMYRDELDALRE 317
++ R +EL+ K E+LL K++ ++E EL+ +++++ LL + A + E + E
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 318 KAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL 377
+L ++ +E LHD+E +RVEE +E NQ+L K ++ ++ + D
Sbjct: 906 AEEMRARLAAKKQELEEILHDLE---SRVEEEEERNQILQNEKKKMQAHIQDLEEQLD-- 960
Query: 378 HELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS 437
E+E + K +L + E KI+++ EE + LE + + E + + + S
Sbjct: 961 ---EEEGARQKLQLEKVTAEA-----KIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECS 1012
Query: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKME 497
S+L+E +K+ L K+ + + + +EE ++ K E
Sbjct: 1013 --SQLAEEEEKA----------KNLAKIRNKQEVMISDLEE-------------RLKKEE 1047
Query: 498 KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
K Q L K L+ E + + Q +L K QL K E L+ R +
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL---KLQLAKKEEELQGALARG----D 1100
Query: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL 617
E H N + +R+ AE L E + + +K E +KR + +EL
Sbjct: 1101 DETLHKNNALKVVRELQAQIAE------------LQEDFESEKASRNKAEKQKRDLSEEL 1148
Query: 618 EHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKK 677
E K ELE+ L + EL K+ + E +ALE+E E + + +++
Sbjct: 1149 EALKT------ELEDTLDTTAAQQELRTKREQEV---AELKKALEEETKNHEAQIQDMRQ 1199
Query: 678 T-LDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
+ + L+ QLE ++ + L++ L + + L C + Q++ E+ E ++++
Sbjct: 1200 RHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAES---EHKRKK 1256
Query: 737 LKKGLELLKASFKKTERLEVSY----QGLDIENQRLQKTLENSNKK-------IQQLESE 785
L ++ L A + +RL V L E + LE + KK LES+
Sbjct: 1257 LDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQ 1316
Query: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
LQD + + LQ+ + S R+ QLE+E SL+++ + E+ +K LEK+ L+ Q
Sbjct: 1317 LQDTQ---ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQL 1373
Query: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGI----YKESCVRLKELEKENKELVKRATIDI 901
++++ I +LE+ K L K+ +E + +LEK L +
Sbjct: 1374 ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQEL---- 1429
Query: 902 KTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLE 961
+DL + +Q+ ++LEK + ++LL +E+S RY + E
Sbjct: 1430 -------DDLTVDLDHQRQVASNLEKKQKKF-------DQLLAEEKSISARYAEERDRAE 1475
Query: 962 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-----ERMV 1016
+ ++ KE K +L LEE+ ++ ++ K ++ + E L +D+ +
Sbjct: 1476 AEARE----KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELE 1531
Query: 1017 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE-KQALKTQLKQLETQN 1075
+S + + + + +E EL +D + +E N ++A+ ++ L+T+ +Q E +
Sbjct: 1532 KSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKK 1591
Query: 1076 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1135
L Q+ L+ + ++Q K++++ L +Q + +++ Q L+
Sbjct: 1592 RLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651
Query: 1136 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1195
+ + +E E+ ++ D + ++ E + +E L + + + A ++ E E
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Query: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVE----QEKMLLENKNHETVAAEYKKLCGENDRLNH 1251
+L D K L D ++ L+ +E++ E N E + ++K + D LN
Sbjct: 1712 ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLN- 1770
Query: 1252 TYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE----AEFSKLKEQYQQLDITSTKLNN 1307
++L E Q + L +K + +L+ A SK K L+ +L
Sbjct: 1771 --AELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEE 1828
Query: 1308 QCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR 1367
Q E ++ + + R +++ + +Q +E D + + + ++ +L+R
Sbjct: 1829 QLEQEAKERAAANKLVRRTEKKLKEIFMQ----VEDERRHADQYKEQMEKANARMKQLKR 1884
Query: 1368 QKEKLEEK 1375
Q E+ EE+
Sbjct: 1885 QLEEAEEE 1892
Score = 171 bits (433), Expect = 6e-42
Identities = 223/1042 (21%), Positives = 443/1042 (42%), Gaps = 138/1042 (13%)
Query: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSL 521
LL++ + + L EEL + ++ +ME+++Q+L ++ IL ++ E +
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 522 QNCQNLSKDLMKEKAQLEKTIETLR---ENSERQIKILEQENEHLNQTVSSLR------- 571
+ + L +K +LE+ + L E E + +IL+ E + + + L
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEE 963
Query: 572 ------QRSQISAEARVKDIE--------------KENKILHESIKETSSKLSKIEFEKR 611
Q +++AEA++K +E KE K++ + I E SS+L++ E + +
Sbjct: 964 GARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAK 1023
Query: 612 QIKK----------ELEHYKEKGERA-EELENELHHLEKENELLQKKITNLKITCEKIE- 659
+ K +LE +K E+ +ELE L+ E LQ +I L+ ++++
Sbjct: 1024 NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083
Query: 660 -----------ALEQENSELERENRKLKKTLD---SFKNLTFQLESLEKENSQLDEENLE 705
AL + + E +N LK + L ES + ++ +++ +
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 706 LRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIEN 765
L +E+LK +EL +++EQ + EL KA ++T+ E Q +
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQ--EVAELKKALEEETKNHEAQIQDM---R 1198
Query: 766 QRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKEN----KSLE 821
QR LE +++++Q + +LE Q L+ + +EL K L+Q++ E+ K L+
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258
Query: 822 QETSQL-----EKDKKQLEKENKRLRQQAEIKD--TTLEENNVKIGNLEKENKTLSKEIG 874
+ +L E D+ ++E K + Q E+ + T LEE K K+ +L ++
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQ 1318
Query: 875 IYKE-----------SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNN 923
+E R+++LE+E L ++ + + L + +++ + +
Sbjct: 1319 DTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKK 1378
Query: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDRYK---LLESKLESTLKK------SLEIKEEK 974
++ +E + K++LL D ++ R + L KLE T + L + +
Sbjct: 1379 KVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDH 1438
Query: 975 IAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS---------GE 1025
+ + LE+ QL E K++ Y + R + E + + +S
Sbjct: 1439 QRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEA 1498
Query: 1026 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1085
++ER++++ ++ + +V +N L+ K+AL+ Q++++ TQ L+ ++ A
Sbjct: 1499 KEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558
Query: 1086 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQ-SSLENENESVIKE 1144
+ + L+ +Q A+ + + T + Q+ + +LLI+Q LE E E K+
Sbjct: 1559 EDAKLRLE---VNMQAMKAQFERDLQTRDEQN----EEKKRLLIKQVRELEAELEDERKQ 1611
Query: 1145 RE-----------DLKSL----------YDSLIKDHEKLELLHERQASEYESLISKHGTL 1183
R DLK L D +IK KL+ + E E + +
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEI 1671
Query: 1184 KSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC 1243
+ K E + + LE QL ++ E + + E++++ E N A+ L
Sbjct: 1672 FAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNS---ASGKSALL 1728
Query: 1244 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1303
E RL +QL +E E Q++ + L + L+ L AE + + Q+ D
Sbjct: 1729 DEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQ 1788
Query: 1304 KLNNQCE----LLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYI 1359
+L Q + L +L+G ++ + + + ++ + Q LEQ + + + R+
Sbjct: 1789 QLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTE 1848
Query: 1360 DKLNELRRQKEKLEEKIMDQYK 1381
KL E+ Q E E + DQYK
Sbjct: 1849 KKLKEIFMQVED-ERRHADQYK 1869
Score = 152 bits (383), Expect = 4e-36
Identities = 174/823 (21%), Positives = 368/823 (44%), Gaps = 117/823 (14%)
Query: 136 QKKEEFIERIQGLDF---DTKAAVAAHIQEVTHNQENVFDLQWM--EVTDMSQEDIEPLL 190
++K + E ++ L DT AA + T ++ V +L+ E T + I+ +
Sbjct: 1139 KQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR 1198
Query: 191 KNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTES----- 245
+ A L+ L ++ ++ L + + GL + + + C +++ ++
Sbjct: 1199 QRHATALEELSEQLEQAKRFKANLEKNKQGLE-----TDNKELACEVKVLQQVKAESEHK 1253
Query: 246 RQHLSVELADAKAKIR---RLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA 302
R+ L ++ + AK+ RLR EL EK +L + EL+ + L+ +++ + DA
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKL---QNELDNVSTLLEEAEKKGIKFAKDA 1310
Query: 303 RSAR-MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE--DNQVLL-- 357
S +D + L+E+ + L S + + +E + ++ + EE ++ + QVL
Sbjct: 1311 ASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQ 1370
Query: 358 ----ETKTMLEDQL--------------EGTRARSDKLHE-------LEKENLQLKAKLH 392
+TK ++D L + A S +L E LEK +L+ +L
Sbjct: 1371 SQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELD 1430
Query: 393 DMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH 452
D+ ++ D R+ L ++ + + S E ++ + E SL
Sbjct: 1431 DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLAR 1490
Query: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
+ E ++ + E +N+ L +E+L ++ D V N + ++EK + L ++VE +
Sbjct: 1491 ALEEALEAKE-EFERQNKQLRADMEDLMSSKDDVGKN---VHELEKSKRALEQQVEEMRT 1546
Query: 513 EIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVS 568
++ + + LQ ++ L ++ KAQ E+ ++T E +E + ++L ++ L +
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELE 1606
Query: 569 SLRQRSQISAEAR------VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHY-- 620
R++ ++ ++ +KD+E + + +++ E +L K++ + + ++ELE
Sbjct: 1607 DERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARA 1666
Query: 621 ---------KEKGERAEELENEL--------------HHLEKENELLQKKITNLKITCEK 657
KE ++ + LE E+ H E+E + L +ITN +
Sbjct: 1667 SRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN---SASG 1723
Query: 658 IEALEQENSELERENRKLKKTLDSFK-NLTFQLESLEKENSQLDEENLELRRNVESLKCA 716
AL E LE +L++ L+ + N+ + K Q+D N EL + + +
Sbjct: 1724 KSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKS 1783
Query: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKT-ERLEVSYQGLDIENQRLQKTLENS 775
QL+ +NKEL+++ ++L+ + K+ FK T LE L+ + ++ K +
Sbjct: 1784 DNARQQLERQNKELKAKLQELEGAV---KSKFKATISALEAKIGQLEEQLEQEAKERAAA 1840
Query: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835
NK +++ E +L+++ M+ + +++ ++ K EQ+EK N ++Q QLE+ +++
Sbjct: 1841 NKLVRRTEKKLKEIFMQVEDERRHADQYK------EQMEKANARMKQLKRQLEEAEEEAT 1894
Query: 836 KEN-KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYK 877
+ N R + Q E+ D T + N+ LS+E+ K
Sbjct: 1895 RANASRRKLQRELDDAT------------EANEGLSREVSTLK 1925
Score = 112 bits (279), Expect = 4e-24
Identities = 163/729 (22%), Positives = 322/729 (44%), Gaps = 84/729 (11%)
Query: 720 MAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI 779
+ Q+ + +EL+++ E+L K E + E +E +Q L E L + L+ +
Sbjct: 844 LLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELF 903
Query: 780 QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEK--- 836
+ E L + Q L++ L +L+ R+E+ E+ N+ L+ E +++ + LE+
Sbjct: 904 AEAEEMRARLAAKKQELEEILHDLE---SRVEEEEERNQILQNEKKKMQAHIQDLEEQLD 960
Query: 837 ENKRLRQQAEIKDTTLEENNVKIGN----LEKENKTLSKEIGIYKESCVRL-KELEKENK 891
E + RQ+ +++ T E K+ LE +N KE + ++ +L +E +
Sbjct: 961 EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020
Query: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
+ A I K V + + + E+LK + EK ELEK K +L + D
Sbjct: 1021 KAKNLAKIRNKQEVMISD--LEERLKKE------EKTRQELEKA---KRKLDGETTDLQD 1069
Query: 952 RYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQD 1011
+ L+++++ LK L KEE++ AR ++ T + LK V++ + + Q+
Sbjct: 1070 QIAELQAQIDE-LKLQLAKKEEELQGALARGDDETLHK---NNALKVVRELQAQIAELQE 1125
Query: 1012 EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ----AEKQALKTQ 1067
+ ++S NK E++ ++ + EL +K L + A Q +Q +
Sbjct: 1126 DFESEKAS------RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179
Query: 1068 LKQLETQNNNLQAQILAL-QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQ 1126
K LE + N +AQI + QR +L+E + Q + AK N N Q L N +
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSE--QLEQAKRFKANLEKNKQ--GLETDNKE 1235
Query: 1127 LLIQQSSLENENESVIKEREDLKSLYDSL---IKDHEKLELLHERQASEYESLISKHGT- 1182
L + L+ +R+ L + L + + ++L + +AS+ ++ + T
Sbjct: 1236 LACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTL 1295
Query: 1183 LKSAHK----------NLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH 1232
L+ A K +LE + +D ++ + +QK L ++ ++E+EK L+ +
Sbjct: 1296 LEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLS--SRIRQLEEEKNSLQEQQE 1353
Query: 1233 ETVAAE---YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAE-- 1287
E A K++ +L T ++ + +++ + K LL +++ RLE +
Sbjct: 1354 EEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKAL 1413
Query: 1288 -FSKLKEQ----YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
+ KL++ Q+LD + L++Q Q+ NLE++ + + L+ + +++
Sbjct: 1414 AYDKLEKTKNRLQQELDDLTVDLDHQ----RQVASNLEKKQK----KFDQLLAEEKSISA 1465
Query: 1343 QNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKL 1402
+ E +D E R+ K L R LEE + + +F R+ + M L
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLAR---ALEEALEAKEEF------ERQNKQLRADMEDL 1516
Query: 1403 IKSKKDINR 1411
+ SK D+ +
Sbjct: 1517 MSSKDDVGK 1525
Score = 95.1 bits (235), Expect = 6e-19
Identities = 137/601 (22%), Positives = 253/601 (42%), Gaps = 60/601 (9%)
Query: 808 KRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK 867
K L Q+ ++ + L+ + +L K K++ K L + LEE N+ L+ E +
Sbjct: 842 KPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETE 901
Query: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
++ +E RL ++E +E++ ++ + L +EK K Q DLE+
Sbjct: 902 LFAEA----EEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957
Query: 928 LTHELEKIGLNKERLLHDEQSTDDRYKLLESK-LESTLKKSLEIKEEKIAALEARLEEST 986
E E +++L ++ + + + K +E + L + S IKE+K+ +E R+ E +
Sbjct: 958 QLDEEEGA---RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKL--MEDRIAECS 1012
Query: 987 NYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDR 1046
+ QL +E + K K R +E M+ + K E+ QE + K+
Sbjct: 1013 S---QLAEEEEKAK---NLAKIRNKQEVMISD---LEERLKKEEKTRQELEKAKRKLDGE 1063
Query: 1047 LIEVERNNATLQAEKQALKTQLKQLETQ--------------NNNLQAQILALQRQTVSL 1092
+++ A LQA+ LK QL + E + NN + LQ Q L
Sbjct: 1064 TTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAEL 1123
Query: 1093 QEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLY 1152
QE + + K + + L+ + +L + L ++ + +E +LK
Sbjct: 1124 QEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKAL 1183
Query: 1153 DSLIKDHE-KLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL 1211
+ K+HE +++ + +R A+ E L + K NLE + LE +L + L
Sbjct: 1184 EEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVL 1243
Query: 1212 EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK 1271
+ +K E E + K + E E DRL +L ++ LQ + N+
Sbjct: 1244 Q----QVKAESEH---KRKKLDAQVQELHAKVSEGDRLR---VELAEKASKLQNELDNVS 1293
Query: 1272 SLLNNSKLEQTRLEAEFSKLKEQYQQL-----DITSTKLN--NQCELLSQLKGNL----- 1319
+LL ++ + + + + L+ Q Q + T KLN ++ L + K +L
Sbjct: 1294 TLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQE 1353
Query: 1320 -EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK--LNELRRQKEKLEEKI 1376
EEE R L++ Q L LQ++ + DL +E + K L + ++LEEK
Sbjct: 1354 EEEEARKNLEK-QVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKA 1412
Query: 1377 M 1377
+
Sbjct: 1413 L 1413
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 202 bits (515), Expect = 2e-51
Identities = 279/1308 (21%), Positives = 575/1308 (43%), Gaps = 188/1308 (14%)
Query: 144 RIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDE 203
++QGLD +++ + ++ + E D+S+E + H I +
Sbjct: 1644 QLQGLDLSSRSLLGIDTEDAIQGRN--------ESCDISKEHTSETTERTPKHDVHQICD 1695
Query: 204 RDEHSETIIELSEERDGLHFLPHASSSA-QSPCGS---PGMKRTESRQHLSVELADAKAK 259
+D + +++ + + P S QSP + PG +T+ EL+ +
Sbjct: 1696 KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPN 1755
Query: 260 IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKA 319
L ++++ +++ +K EN+ LL + ++
Sbjct: 1756 AL--------VPMDFLGNQEDIHNLQLRVKETSNENLRLLH-------------VIEDRD 1794
Query: 320 VRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE-DQLEGTRARSDKLH 378
+V+ L +E+ +LH ++ Q++ + + +E +++ G
Sbjct: 1795 RKVESLLNEMKELDSKLH------------LQEVQLMTKIEACIELEKIVG--------- 1833
Query: 379 ELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEM-AQKQSMDE------SLHLGW 431
EL+KEN L KL + +++E N LEM A K S ++ ++ W
Sbjct: 1834 ELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSW 1893
Query: 432 ELEQISRTSELSE--APQKSLGHEVN------ELTSSRLLKLEMENQSLTKTV----EEL 479
+ + +ELS + + S+ HE E+ + L LE +N++ K + EEL
Sbjct: 1894 KERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEEL 1953
Query: 480 RTTV---DSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
+ + G + K +LS+K++ E+ + +C +++ +KEK
Sbjct: 1954 SVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKT 2013
Query: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA------EARVKDIEKENK 590
+L +T+ + + L ++ HL + + SL + SQ + E ++ + KE +
Sbjct: 2014 ELLQTLSS-------DVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKE 2066
Query: 591 ILHESIKETSSKLSKIEFEKRQIKKELEH-YKEKGERAEELENELHHLEKENELLQKKIT 649
+L + + ++LS+ ++EK + K LE EKGE A L + ++E L++ I
Sbjct: 2067 LLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSST----QEEVHQLRRGIE 2122
Query: 650 NLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLEL--- 706
L++ +IEA E++ + + ++ ++ DS K+ ++E+LE+E Q+ EEN EL
Sbjct: 2123 KLRV---RIEADEKKQLHIAEKLKERERENDSLKD---KVENLERE-LQMSEENQELVIL 2175
Query: 707 -----RRNVESLKCASMKMAQ----LQLENKELESEKEQLKKGLELLKASFKKTERLEVS 757
+ VE+LK +MA+ +L+ L SEKE L K ++ + + ++L S
Sbjct: 2176 DAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSS 2235
Query: 758 YQGLDIENQRLQKTL-ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ-LEK 815
++ L E ++ + + E S ++ L+++L++L L + E +K + + L+ +E+
Sbjct: 2236 FKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEE 2295
Query: 816 ENK---SLEQETSQLEKDKKQ---LEKENKRLRQQAEIKDTTLE--ENNVKIGNLEKENK 867
E++ S+E+ ++LE D+K+ + ++ K A++ +E E ++I +E+
Sbjct: 2296 EHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHA 2355
Query: 868 TLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEK 927
L E K LK + + ++ +D+ T+ + +E+L +E K Q+ ++LE
Sbjct: 2356 ALEAENS--KGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEI 2413
Query: 928 LTHELEKIGLNKER-LLHDEQSTDDRYKLLESKLE------STLKKSLEIKEEKIAALEA 980
+ E I KE+ + ++ + ++L+++L+ + L E + K L +
Sbjct: 2414 INSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSS 2473
Query: 981 RLEESTNYNQQLRQELKTVKKNYEALK-----------------------------QRQD 1011
++E QL Q L K NY L+ Q QD
Sbjct: 2474 QVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD 2533
Query: 1012 EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQL 1071
+E++V + GE W+ ++ E ++++ ++ ++ NA+LQ + L++ K L
Sbjct: 2534 QEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL 2593
Query: 1072 ETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNA---QLL 1128
E + + ++ + + + T LQ + ++ + + L + + N+ A QLL
Sbjct: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653
Query: 1129 IQQ-SSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI----SKH-GT 1182
+++ S +++ + + E +LK D + KD + E + +EY+ + KH
Sbjct: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL 2713
Query: 1183 LKSAHKNLEVE----HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAE 1238
L +K EVE L + L QK +++ +LK +E++ K + E
Sbjct: 2714 LLDTNKQYEVEIQTYREKLTSKEECLSSQKLEID----LLKSSKEELNNSLKATTQILEE 2769
Query: 1239 YKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKL---KEQY 1295
KK + D L + +QL KE E Q K L + E+ L+ E S+L +E+
Sbjct: 2770 LKKT--KMDNLKYV-NQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQ 2826
Query: 1296 QQLDITSTKLNNQCELLSQLKGNLEEENR---HLLDQIQTLMLQNRTL 1340
+ + TK++ + +LK LEE+ + LD+ +L++ + L
Sbjct: 2827 KTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL 2874
Score = 186 bits (472), Expect = 2e-46
Identities = 251/1082 (23%), Positives = 479/1082 (44%), Gaps = 150/1082 (13%)
Query: 206 EHSETIIELSEERDGLH--FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRL 263
+H E +++ E +GL+ HA S++ G K +S + D + ++ R+
Sbjct: 1852 DHQE-LLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKE---RFLDVENELSRI 1907
Query: 264 RQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL----------LSDARSAR-MYRDEL 312
R E + L + +LE ++ E L+++N N LS S R R EL
Sbjct: 1908 RSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGEL 1967
Query: 313 DALREKAVRVDKLESEV--------SRYKERLHDIEFYKARVEELKEDNQVLLETKTMLE 364
D + +K +D+L ++ S E LH I+ +A E+KE ++L + +
Sbjct: 1968 DTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEA---EVKEKTELLQTLSSDVS 2024
Query: 365 DQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD 424
+ L+ +KL LEK++ L ++E + K+ E L++E+ +L+ +S
Sbjct: 2025 ELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQARLSESDY 2084
Query: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD 484
E L++ LE + L E + +L RL + E L + +E+LR ++
Sbjct: 2085 EKLNVSKALE-----AALVEKGEFAL----------RLSSTQEEVHQLRRGIEKLRVRIE 2129
Query: 485 SVEGN----ASKILKMEKENQRLSKKVEILENEIVQEKQSLQ----NCQNLSKDLMKEKA 536
+ E A K+ + E+EN L KVE LE E+ +++ + + +N ++ K
Sbjct: 2130 ADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKT 2189
Query: 537 QLEK-------------TIETLRENSERQIKILEQENEHLNQTVSSLRQ--RSQISAEAR 581
Q+E+ T+ + +EN +QI+ + + L++ +SS + + AE +
Sbjct: 2190 QIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQ 2249
Query: 582 VKD--------IEKENKILHESI----------KETSSKLSKIEFEKRQIKKELEHYKEK 623
+K+ ++ + K L+E++ K T L E+ Q++ +E + +
Sbjct: 2250 IKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRAR 2309
Query: 624 GERAEELE----NELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-KT 678
E E+ + +L E +LL+ ++ NL+ E I QE++ LE EN K + +T
Sbjct: 2310 LEADEKKQLCVLQQLKESEHHADLLKGRVENLERELE-IARTNQEHAALEAENSKGEVET 2368
Query: 679 LDS-FKNLTFQLESLEKE--NSQLDEENLELRRNVESLKCASMKMAQLQLEN--KELESE 733
L + + +T L LE + + ++ENL E + + +++ EN +E E E
Sbjct: 2369 LKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKEQE 2428
Query: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
K Q+K+ S E L+ + L+ L E K Q L S+++ LE+E
Sbjct: 2429 KVQMKE------KSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEK 2482
Query: 794 QTLQKNLEELKIS--------SKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
L + L+E K + + ++++E + LE++ ++ + K Q++ + + + + +
Sbjct: 2483 AQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLS 2542
Query: 846 EI-------KDTTLEENNV------KIGNLEKENKTLSKEIGIYKESCVRLKELEKENKE 892
++ K+ LE N+ KI L+ +N +L + + + S L E E E +
Sbjct: 2543 QVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL-ENELELTK 2601
Query: 893 LVKRATIDIKTLVTLRE-DLVSEKLKTQQMNNDL-EKLTHELEKIGLNKERLLHDEQSTD 950
+ K + ++ +T +E +L E + Q +L E+L+ E ++ + LL + +S+
Sbjct: 2602 MDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSK 2661
Query: 951 DRYKLLESKLESTLKKSLEIKE-----------EKIAALEARLEESTNYNQQLRQELKTV 999
D+ K L + S LKKSL+ E+IA + RL E+ +Q L L
Sbjct: 2662 DQLKELTLE-NSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL---LLDT 2717
Query: 1000 KKNYEALKQRQDEERMVQSSPPISGEDNKWE--RESQETTRELLKVKDRLIEVERNNATL 1057
K YE Q E++ +S + + + + S+E LK +++E L
Sbjct: 2718 NKQYEVEIQTY-REKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILE------EL 2770
Query: 1058 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1117
+ K + QL+ +N Q ++ L + L+E+ LQ + ++LQ +
Sbjct: 2771 KKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKT-G 2829
Query: 1118 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1177
T + + +L + L+ E KE ++ Y SL+ HEKLE E ++ L
Sbjct: 2830 TVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLC 2889
Query: 1178 SK 1179
S+
Sbjct: 2890 SQ 2891
Score = 158 bits (399), Expect = 5e-38
Identities = 264/1261 (20%), Positives = 540/1261 (42%), Gaps = 180/1261 (14%)
Query: 247 QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
Q L +L K + ++ + +L+ L KQ++E + E L++EN L+ S
Sbjct: 21 QELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEICESLE 80
Query: 307 MYRDELD---ALREKAV------------RVDKLESEVSRYKERLH---------DI--- 339
+ ++ ++E V +++KLE E+ R K L D+
Sbjct: 81 KTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLN 140
Query: 340 ----------------EFYK-ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEK 382
++Y ++ E+LKE +E + LE +++ +A+ +
Sbjct: 141 PCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAK-------KA 193
Query: 383 ENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMD------ESLHLGWELEQI 436
+A ++ ++ R + +E ++ + + E E
Sbjct: 194 SQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVT 253
Query: 437 SRTSELSEAPQKSLGHEVNELTSSRLL-KLEMENQSLTKTVEELRTTVD----SVEGNAS 491
S L + + + +S LL +L+ +NQ L + EL + ++G +
Sbjct: 254 PSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVN 313
Query: 492 KI----LKMEKENQRLSKKVEIL---ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIET 544
K L++EK L +K ++L +E+V+ L ++ +L + +
Sbjct: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSC 373
Query: 545 LRENSERQIKILEQ---ENEHLNQTVSSLRQRS-------QISAEARVKDIEKENKILHE 594
R+N+E LEQ E E Q S +QRS I +AR+ ++ K +H
Sbjct: 374 QRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHN 433
Query: 595 SIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE-----------ELENELHHLEKENEL 643
++ KL+ + K+Q++ LE +K+K RAE EL + ++KEN L
Sbjct: 434 VLQAELDKLTSV---KQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNL 490
Query: 644 LQ-------KKITNLKITCEKI-EALEQENS---ELERENRKLKKTL-DSFKNLTFQLES 691
L+ +++ +L+ + I + L Q + E++ +N + L D + + Q S
Sbjct: 491 LKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENS 550
Query: 692 LEKENSQLDEENLELRRNV--ESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK 749
L E +L +LE +R+ + LK + QL + + E E + L LEL K ++
Sbjct: 551 LTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYE 610
Query: 750 KTERLEVSYQGLDIENQRL----QKTLENSNKKIQQLESELQDLEMEN-------QTLQK 798
+ + + + EN++L + EN KI LE+ L+ ++++ +TL+
Sbjct: 611 ELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEM 670
Query: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNV- 857
+ E L + + L + ++KS+E ET +L + Q + E + Q EI++ L+ + +
Sbjct: 671 DRENLSVEIRNLHNV-LDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLT 729
Query: 858 -KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN-KELVKRATIDIKTLVTLREDLVSEK 915
++ +LE + + LS EI + K+ C + E E+ ++L+K + T + L++
Sbjct: 730 GQVEDLEHKLQLLSNEI-MDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFD 788
Query: 916 LKTQQMNN------DLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLE 969
+ ++ + + E + L ++ + +R LE LES + + +
Sbjct: 789 QQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSD 848
Query: 970 IKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS--SPPISGE 1025
+++ E++ ++ +EE+ +Q+ Q V + + + + Q++ Q+ + +S
Sbjct: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSF--VAETSQRISKLQEDTSAHQNVVAETLSAL 906
Query: 1026 DNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILAL 1085
+NK E+E Q ++ + + E++++N L+ + L+ + L + + + I
Sbjct: 907 ENK-EKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN 965
Query: 1086 QRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMN---QNAQLLIQQSSLENENESVI 1142
+R+ L ++N TL+ NA L E L +S S N + + + + S + + ++
Sbjct: 966 KREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLIL 1025
Query: 1143 KER--------EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSA----HKNL 1190
+R EDL Y + + + KLE L S E+ ++ LK A H+
Sbjct: 1026 LQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEF 1085
Query: 1191 EVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA-----EYKKLCGE 1245
+ E+R L+ +LE +++ L+ E + +N+N+ A E L E
Sbjct: 1086 LTKLAFAEERNQNLML---ELETVQQALRSE----MTDNQNNSKSEAGGLKQEIMTLKEE 1138
Query: 1246 NDRLNHTYSQLLKETE----VLQTDH--KNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD 1299
+++ + LL+E E V++T H +NL+S + +++ E K Q L+
Sbjct: 1139 QNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQCNFKPQ-MDLE 1197
Query: 1300 ITSTKLNNQCELLSQLKGNL----------EEENRHLLDQIQTLMLQNRTLLEQNMESKD 1349
+ L++ L QL+ L E+E L ++QT+ T Q+M+S++
Sbjct: 1198 VKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQE 1257
Query: 1350 L 1350
+
Sbjct: 1258 I 1258
Score = 155 bits (392), Expect = 3e-37
Identities = 267/1235 (21%), Positives = 517/1235 (41%), Gaps = 175/1235 (14%)
Query: 279 QELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHD 338
Q+++++E +L +L++E +++ ++D LE+ + + K++
Sbjct: 18 QKIQELEGQLDKLKKEK--------------------QQRQFQLDSLEAALQKQKQK--- 54
Query: 339 IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMER 398
+E K LK +NQ L+E + + LE T+ + HEL+ + Q+ + + +
Sbjct: 55 VENEKTEGTNLKRENQRLME----ICESLEKTKQKIS--HELQVKESQVNFQEGQLNSGK 108
Query: 399 DMDRKKIEELMEENMTLEMAQK--QSMDESLHLGWELEQISRT-----SELSEAPQKSLG 451
K +EL LE +Q+ QS D SL+ ++I T S + + L
Sbjct: 109 KQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLK 168
Query: 452 HEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
+ N+ R +LE E ++L ++ T+ N I + + + S + E
Sbjct: 169 EKYNKEVEER-KRLEAEVKAL--QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTP 225
Query: 512 NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLR-------------ENSERQIKILEQ 558
+ + Q ++ S + ++ + TL+ +S + L+
Sbjct: 226 SHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKA 285
Query: 559 ENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE 618
+N+ L ++ L E R++ EKE K +E +L K + E + +K L
Sbjct: 286 QNQELRNKINEL--------ELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLN 337
Query: 619 HYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA------LEQENSELERE- 671
+++ R ++ E KK+T ++C++ A LEQ+ E E+E
Sbjct: 338 KCRDELVRTTAQYDQASTKYTALEQKLKKLTE-DLSCQRQNAESARCSLEQKIKEKEKEF 396
Query: 672 NRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELE 731
+L + SF+ L + ++ +Q + + + NV + + + QLEN LE
Sbjct: 397 QEELSRQQRSFQTLDQECIQMKARLTQ-ELQQAKNMHNVLQAELDKLTSVKQQLEN-NLE 454
Query: 732 SEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
K++L + + +AS K L S + + EN L+ E +++ LE+EL++++
Sbjct: 455 EFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQ 514
Query: 792 ENQTLQKNLEELKISSKRLEQL--EKENKSLEQETS-QLEKDK---KQLEKENKRLRQQA 845
Q EE+K + E + + + K +QE S LEK K LEK+ +
Sbjct: 515 CLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLL 574
Query: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
+ ++ +E+ N K+ EKE+K L + + K+ L KE K L + + L+
Sbjct: 575 KKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEEL----KEEKTLFSCWKSENEKLL 630
Query: 906 TLREDLVSEKLKTQQMNNDLEKL--THELEKIGLNK--ERLLHDEQSTDDRYKLLESKLE 961
T E SEK Q N LE T +++ N+ L D ++ + L + L+
Sbjct: 631 TQME---SEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLD 687
Query: 962 STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1021
S KS+E++ +K+A +E L++ ++ Q K +++ E M +
Sbjct: 688 S---KSVEVETQKLAYME--LQQKAEFSDQ---------------KHQKEIENMCLKTSQ 727
Query: 1022 ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQ---NNNL 1078
++G+ E + Q + E++ KDR + L AE ++L+ LK + N +
Sbjct: 728 LTGQVEDLEHKLQLLSNEIMD-KDRCYQ------DLHAEYESLRDLLKSKDASLVTNEDH 780
Query: 1079 QAQILALQRQT------VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQS 1132
Q +LA +Q ++ + ++ ++ ++ ++E S L N+ L
Sbjct: 781 QRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLE 840
Query: 1133 SLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN--- 1189
S + N + K+ E+L + + ++ K E +H+ +E ISK SAH+N
Sbjct: 841 SQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVA 900
Query: 1190 -----LEVEHRDL----------EDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHET 1234
LE + ++L + +L K LED K L++ E + LE K +
Sbjct: 901 ETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSS 960
Query: 1235 VAA----EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1290
+ + E ++L EN L + L +E L ++ + ++ E S+
Sbjct: 961 IISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDER-------EKSISE 1013
Query: 1291 LKEQYQQLDI----TSTKLNNQCELLSQLKGNLEEENRH---LLDQIQTLMLQNRTLLEQ 1343
L +QY+Q + + N E LSQ +E+N LL++ +L + LEQ
Sbjct: 1014 LSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQ 1073
Query: 1344 NMESKDLFHVEQRQYIDKLN-----------ELRRQKEKLEEKIMDQYKFYDPSPPRRRG 1392
K+ F E ++++ KL EL ++ L ++ D +
Sbjct: 1074 ---LKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQ 1130
Query: 1393 NWITLK--MRKLIKSKKDINRERQKSLTLTPTRSD 1425
+TLK K+ K D+ +E ++ + + T+ +
Sbjct: 1131 EIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHE 1165
Score = 153 bits (386), Expect = 2e-36
Identities = 243/1190 (20%), Positives = 510/1190 (42%), Gaps = 152/1190 (12%)
Query: 251 VELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
VEL + + + + R EL T Q + +E +LK+L ++ +A SAR +
Sbjct: 327 VELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLE 386
Query: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEF----YKARV----EELKEDNQVL---LET 359
+ +EK + + E+SR + ++ KAR+ ++ K + VL L+
Sbjct: 387 QKIKEKEK-----EFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDK 441
Query: 360 KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
T ++ QLE + L E +++ + + +++ + R+ +EE+ +EN L+
Sbjct: 442 LTSVKQQLE------NNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHS 495
Query: 420 KQSMDESLHLGWELEQISRTSELSEA-PQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
+Q E HL EL+ I + S+ ++ ++ T R L+ ++ Q + T+E+
Sbjct: 496 EQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEK 555
Query: 479 LRTTVDSVEGNAS------------------KILKMEKENQRLSKKVEILENEI--VQEK 518
L+ V +E K+ K EKE++ L +E+ + E ++E+
Sbjct: 556 LKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEE 615
Query: 519 QSLQNCQNLSKDLMKEKAQLEK-TIETLRENSERQIKILEQENEHLNQTVSSLRQ-RSQI 576
++L +C + + + + EK +++ + E +K + ++ N+ V +L R +
Sbjct: 616 KTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENL 675
Query: 577 SAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGE---RAEELENE 633
S E R N + +S++ + KL+ +E +++ + +H KE + +L +
Sbjct: 676 SVEIR----NLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQ 731
Query: 634 LHHLEKENELLQKKITNLKITCEKIEA--------LEQENSELERENRKLKKTL------ 679
+ LE + +LL +I + + + A L+ +++ L + L
Sbjct: 732 VEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQP 791
Query: 680 ---DSFKNLTFQLESLEKENS-------QLDEENLELRRNVESLKCASMKMAQLQLENKE 729
SF N+ + S+ E S Q + + L+ V+SL+ + Q+ N +
Sbjct: 792 AMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQM---NSD 848
Query: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
L+ + E+L + ++ + K E++ S+ + +QR+ K E+++ + L L
Sbjct: 849 LQKQCEELVQIKGEIEENLMKAEQMHQSF--VAETSQRISKLQEDTSAHQNVVAETLSAL 906
Query: 790 EMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKD 849
E + + LQ ++++ +++L+K N LE +L+ + L E K + +
Sbjct: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966
Query: 850 TTLEENNVKIGNLEKENKTLSKE-IGIYKES---CVRLKELEKENKELVKRATIDIKTLV 905
+EE + G L++ N +L++E + + ++S + E EK EL + + L+
Sbjct: 967 REIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILL 1026
Query: 906 -------TLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLES 958
EDL + Q+ N+ LE L +E + N++ L ++ K +
Sbjct: 1027 QRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNEL-------EQLKEAFA 1079
Query: 959 KLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQS 1018
K L EE+ L LE Q LR E+ + N + + + Q
Sbjct: 1080 KEHQEFLTKLAFAEERNQNLMLELE---TVQQALRSEMTDNQNN-----SKSEAGGLKQE 1131
Query: 1019 SPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ-AEKQALKTQLKQLETQNNN 1077
+ E NK ++E +LL+ ++L++V + Q E + ++ +K+ E++ N
Sbjct: 1132 IMTLKEEQNKMQKE----VNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESERNQ 1187
Query: 1078 LQAQILALQRQTVSLQEQNTTLQTQNAKL-QVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1136
+ + L+ + +L + NA+L Q+E M +N +L +Q+S E
Sbjct: 1188 CNF------KPQMDLEVKEISLDSYNAQLVQLE----------AMLRNKELKLQES--EK 1229
Query: 1137 ENESVIKEREDLK-SLYDSLIKDHEKLEL--LHERQASEYESLISKHGTLKSAHKNLEVE 1193
E E + E + ++ L S ++D + E+ L + + E IS L ++ +
Sbjct: 1230 EKECLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHL 1289
Query: 1194 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLE-NKNHETVAAEYKKLCGENDRLNHT 1252
L+ N+L +LE + ++L+ E+ +++ E N + +K+ E
Sbjct: 1290 QCSLQTTMNKL----NELEKICEILQAEKYELVTELNDSRSECITATRKMAEE------- 1338
Query: 1253 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1312
+LL E ++L D S L + +L + EF + + + + +N E L
Sbjct: 1339 VGKLLNEVKILNDD-----SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHL 1393
Query: 1313 SQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1362
+ ++ L ++ +L +++ L +Q+ + E + Y+D L
Sbjct: 1394 TLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMS-ELQTYVDSL 1442
Score = 153 bits (386), Expect = 2e-36
Identities = 222/981 (22%), Positives = 445/981 (45%), Gaps = 151/981 (15%)
Query: 209 ETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELE 268
E + ++ ER+ L S + K E Q L ++ I+ E++
Sbjct: 1951 EELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVK 2010
Query: 269 EKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDAL-----REKAVRVD 323
EKTE L ++ ++ + LQ++ +L D+++ + + EL+ +EK + V
Sbjct: 2011 EKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVK 2070
Query: 324 KLESEVSRYKERLHD-IEFYKARVEELKEDNQVLLETKTMLED--QLE-GTRARSDKLHE 379
+ ES +R E ++ + KA L E + L + E+ QL G ++
Sbjct: 2071 ESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEA 2130
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRT 439
EK+ L + KL + E E D + K+E L E L+M+++ E +
Sbjct: 2131 DEKKQLHIAEKLKERERENDSLKDKVENLERE---LQMSEENQ-----------ELVILD 2176
Query: 440 SELSEAPQKSLGHEVNELTSSR------LLKLEMENQSLTKTVEELRTTVDSVEGNAS-- 491
+E S+A ++L ++ E+ S L+ L E ++LTK ++E + + ++ S
Sbjct: 2177 AENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSF 2236
Query: 492 KILKMEKENQRLSKK------VEILENEIVQ----------EKQSLQNCQNLSKDLMKEK 535
K L EKE + K VE+L+N++ + +++ ++ + ++E+
Sbjct: 2237 KSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEE 2296
Query: 536 AQLEKTIETLRENSE----RQIKILEQ--ENEH----LNQTVSSLRQRSQIS-------- 577
QL +IE LR E +Q+ +L+Q E+EH L V +L + +I+
Sbjct: 2297 HQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAA 2356
Query: 578 -----AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
++ V+ ++ + + + +S++ + I EK + EL+ +E+ E + +
Sbjct: 2357 LEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINS 2416
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK----NLTFQ 688
++ +E E Q+K+ + + +E L+ + EL L ++ K NL+ Q
Sbjct: 2417 SFENILQEKE--QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQ 2474
Query: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE-LESEKEQLKKGLELLKAS 747
+E LE E +QL + E + N L+ + + Q + K+ LE + E++ + LK
Sbjct: 2475 VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISR----LKNQ 2530
Query: 748 FKKTERLEVSYQGLDIENQRL-QKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS 806
+ E+L ++ E+Q ++ LE N ++ LE ++Q L+ +N +LQ LE L+ S
Sbjct: 2531 IQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVE-LEQKIQVLQSKNASLQDTLEVLQSS 2589
Query: 807 SKRLE-------------------------QLEKENKSLEQETSQLEKD----KKQLEKE 837
K LE +L++E + Q+T++L+++ K +L E
Sbjct: 2590 YKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGE 2649
Query: 838 NKRLRQQA-----EIKDTTLEENNVKIG-------NLEKENKTLSKEIGIYKESCVRLKE 885
+ L ++ ++K+ TLE + +K +EKE K + +EI Y+ +RL E
Sbjct: 2650 LQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGK-VREEIAEYQ---LRLHE 2705
Query: 886 LEKENKELV----KRATIDIKTLVTLREDLVSEK--LKTQQMNNDLEKLTHELEKIGLNK 939
EK+++ L+ K+ ++I+T RE L S++ L +Q++ DL K + K
Sbjct: 2706 AEKKHQALLLDTNKQYEVEIQTY---REKLTSKEECLSSQKLEIDLLKSS---------K 2753
Query: 940 ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV 999
E L + ++T + L+ LK ++K+E A + +++ +QL +E + +
Sbjct: 2754 EELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERA-QGKMKLLIKSCKQLEEEKEIL 2812
Query: 1000 KKNYEALKQRQDEER----MVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1055
+K L+ Q++++ M ++ E + + +E T+E + D+ + ++
Sbjct: 2813 QKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHE 2872
Query: 1056 TLQAEKQALKTQLKQLETQNN 1076
L+ K+ L+TQ+ L +Q +
Sbjct: 2873 KLEKAKEMLETQVAHLCSQQS 2893
Score = 142 bits (359), Expect = 2e-33
Identities = 267/1266 (21%), Positives = 538/1266 (42%), Gaps = 132/1266 (10%)
Query: 177 EVTDMSQEDIEPLLKNMALHLKRLIDE----RDEHSETIIELSEERDGLHFLPHASSSAQ 232
E+ D E I K MA + +L++E D+ EL E+ G F + Q
Sbjct: 1320 ELNDSRSECITATRK-MAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEF--GEQPNEQ 1376
Query: 233 SPCGSPGMKRTESRQHLSVE-------LADAKAKIRRLRQELEEKTEQLLDCKQELEQME 285
P + + S +HL++ A+ + K L+ E + +Q ++ +++
Sbjct: 1377 HPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQ 1436
Query: 286 IELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEV---SRYKERLHDIEFY 342
+ L+ EN+ L ++ R+ + + L + V L S S L D FY
Sbjct: 1437 TYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFY 1496
Query: 343 KARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLH--ELEKENLQLKA----------- 389
+A +E+ + + + LE + + D++ L++ENL K
Sbjct: 1497 RALLEQTGD-----MSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKGVEE 1551
Query: 390 -------------KLHD-MEMERDMDRKKIEELME----ENMTLEMAQKQSMDESLHLGW 431
KL + ME + M K+I+EL + E L+ +KQ + E+
Sbjct: 1552 LESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ 1611
Query: 432 ELEQISRTSELSEAPQKSLGHEVN---ELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
+L ++ E A +K +++ E+ +L L++ ++SL T D+++G
Sbjct: 1612 KLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSSRSLLGI-----DTEDAIQG 1666
Query: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
++ + KE+ S+ E V + Q+L+ D+ EK ++ E
Sbjct: 1667 R-NESCDISKEHT--SETTERTPKHDVHQICDKDAQQDLNLDI--EKITETGAVKPTGEC 1721
Query: 549 SERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEF 608
S Q E ++T S S++S + + E I ++ +
Sbjct: 1722 SGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSN 1781
Query: 609 EKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSEL 668
E ++ +E ++ + E L NE+ L+ + L + ++ C ++E + EL
Sbjct: 1782 ENLRLLHVIE---DRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIV---GEL 1835
Query: 669 ERENRKLKKTLDSF----KNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
++EN L + L+ F + L ++E+ E NS +LE+ + S + +A++
Sbjct: 1836 KKENSDLSEKLEYFSCDHQELLQRVETSEGLNS-----DLEMHADKSSREDIGDNVAKVN 1890
Query: 725 LENKELESEKEQLKKGLELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
KE + E + KAS + + LE + + E L+K EN K I LE
Sbjct: 1891 DSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLE 1950
Query: 784 SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
EL + E L+ L+ + SK+ L++ ++ ++++T +LE Q E +
Sbjct: 1951 EELSVVTSERNQLRGELDTM---SKKTTALDQLSEKMKEKTQELESH--QSECLHCIQVA 2005
Query: 844 QAEIKDTT--LEENNVKIGNLEKENKTLSKEIGIYKESCVRLK----ELEKENKELVKRA 897
+AE+K+ T L+ + + L K+ L +++ ++ L ELE + +L K
Sbjct: 2006 EAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEK 2065
Query: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKL--THELEKIGLNKERLLHDEQSTDDRYKL 955
+ +K SE L+ + +D EKL + LE + K ST +
Sbjct: 2066 ELLVKE---------SESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQ 2116
Query: 956 LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERM 1015
L +E L+ +E E+K + +L+E N L+ +++ +++ + ++ Q E +
Sbjct: 2117 LRRGIEK-LRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQ--ELV 2173
Query: 1016 VQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1075
+ + E++K E E+ +T E + ++ E++ TL++EK+ L Q+++ + Q
Sbjct: 2174 I-----LDAENSKAEVETLKTQIEEMARSLKVFELDL--VTLRSEKENLTKQIQEKQGQL 2226
Query: 1076 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVEN-----STLNSQSTSLMNQNAQLLIQ 1130
+ L ++L+ + + +EQ + +K VE LN +L +
Sbjct: 2227 SELD-KLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKAT 2285
Query: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEK-LELLHERQASEYESLISKHGTLKSAHKN 1189
+ SL+ E + R ++ L L D +K L +L + + SE+ + + K G +++ +
Sbjct: 2286 EQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLK-GRVENLERE 2344
Query: 1190 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRL 1249
LE+ + E + KG++E L+ ++ + + + T+ +E + L E +
Sbjct: 2345 LEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKE 2404
Query: 1250 NHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQC 1309
S+L E++ + +N+ L + E+ +++ + S E Q +LN +
Sbjct: 2405 QERISEL----EIINSSFENI---LQEKEQEKVQMKEKSSTAMEMLQT---QLKELNERV 2454
Query: 1310 ELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQK 1369
L + + + ++L Q++ L L+ LL+ E+K+ + V Q + E+ K
Sbjct: 2455 AALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGK 2514
Query: 1370 EKLEEK 1375
+KLE+K
Sbjct: 2515 QKLEKK 2520
Score = 138 bits (348), Expect = 4e-32
Identities = 281/1289 (21%), Positives = 519/1289 (40%), Gaps = 239/1289 (18%)
Query: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ----ENMNLL 299
+ + L+ EL AK L+ EL++ T + LE+ + +L R +Q +
Sbjct: 416 QMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKEN 475
Query: 300 SDARSARMYRDELDALR----EKAVRVDKLESEVSRYKERLHDIEFYKARVEELK----- 350
RS + E + L+ +KA V LE+E+ K+ L+ + + EE+K
Sbjct: 476 ELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNF---AEEMKAKNTS 532
Query: 351 --------------EDNQVLLETKTMLEDQLEGTR-ARSDKLHELEKENLQLKAKLHDME 395
++N + LE + LE R D L + E QL KL E
Sbjct: 533 QETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTE 592
Query: 396 MER-------DMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE---- 444
E ++ +K+ EEL EE TL K S +E L E E+ + S+++
Sbjct: 593 KESKALLSALELKKKEYEELKEEK-TLFSCWK-SENEKLLTQMESEKENLQSKINHLETC 650
Query: 445 -APQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD--SVEGNASKILKMEKEN- 500
Q+ HE NE R+ LEM+ ++L+ + L +D SVE K+ ME +
Sbjct: 651 LKTQQIKSHEYNE----RVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
Query: 501 --------------------------QRLSKKVEILENEIVQEKQSLQNCQ---NLSKDL 531
+ L K+++L NEI+ + + Q+ +DL
Sbjct: 707 AEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDL 766
Query: 532 MKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIE----- 586
+K K + ++ T E+ +R + +Q+ + + + ++ + +E +E
Sbjct: 767 LKSK---DASLVT-NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSP 822
Query: 587 KENKILH----------ESIKETSSKLSKIEFEKRQIKKELEHYKEKGER-----AEELE 631
K + IL ES K+ +S L K E QIK E+E K E+ E
Sbjct: 823 KNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETS 882
Query: 632 NELHHLEKEN-----------ELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD 680
+ L+++ L+ K L++ +K+E + E EL++ N L+ +L
Sbjct: 883 QRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLK 942
Query: 681 SFKNL--TFQLESLE---------KENSQLDEENLELRRNVESLKCASMKMAQ------- 722
+ L T LE E +E +L +EN L+ SL M + Q
Sbjct: 943 ELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFAN 1002
Query: 723 -LQLENKELESEKEQLKKGLELLKASFKKT----ERLEVSYQGLDIENQRLQKTL----- 772
+ K + +Q K+ +L ++T E L Y+ +N +L+ L
Sbjct: 1003 YIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTS 1062
Query: 773 --ENSNKKIQQLE-----------SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKS 819
EN +++QL+ ++L E NQ L LE ++ + R E + +N S
Sbjct: 1063 LCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQ-QALRSEMTDNQNNS 1121
Query: 820 -------------LEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKEN 866
L++E ++++K+ L +EN++L + + K + I N KE
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKER 1181
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
++ + + + +KE+ ++ LV L L +++LK Q+ + E
Sbjct: 1182 ESERNQCNFKPQMDLEVKEISLDSYN---------AQLVQLEAMLRNKELKLQESEKEKE 1232
Query: 927 KLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLK-----KSLEIKEEKIAALEAR 981
L HEL+ I + E + + + L + ++++ K L + A L+
Sbjct: 1233 CLQHELQTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCS 1292
Query: 982 LEESTNYNQQLRQELKTVK-KNYEALKQRQD-EERMVQSSPPISGEDNKWERESQETTRE 1039
L+ + N +L + + ++ + YE + + D + ++ ++ E K E + +
Sbjct: 1293 LQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDD 1352
Query: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN---------NLQAQILALQRQTV 1090
+ L+E + + L L+ N+ +Q LQ + +
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFL 1412
Query: 1091 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE---- 1146
SLQ ++ L Q+ ++ + S L + SL +N L+ ++L N ++KE +
Sbjct: 1413 SLQSEHKILHDQHCQMSSKMSELQTYVDSLKAEN---LVLSTNLRNFQGDLVKEMQLGLE 1469
Query: 1147 --DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQL 1204
+ SL S + D L L + +S Y +L+ + G + S NLE + +++
Sbjct: 1470 EGLVPSLSSSCVPDSSSLSSLGD--SSFYRALLEQTGDM-SLLSNLEGAVSANQCSVDEV 1526
Query: 1205 LKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE--- 1261
Q E+L + ET +A K + E + L Y Q L++ E
Sbjct: 1527 FCSSLQEENLTR---------------KETPSAPAKGV-EELESLCEVYRQSLEKLEEKM 1570
Query: 1262 -----VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLK 1316
+ + + L+ LL++ + E L ++ EQ+QQ +TS L + +L ++ K
Sbjct: 1571 ESQGIMKNKEIQELEQLLSSERQELDCLRKQYLSENEQWQQ-KLTSVTLEMESKLAAEKK 1629
Query: 1317 G----NLEEENRHLLDQIQTLMLQNRTLL 1341
+LE E L Q+Q L L +R+LL
Sbjct: 1630 QTEQLSLELEVARL--QLQGLDLSSRSLL 1656
Score = 137 bits (344), Expect = 1e-31
Identities = 203/953 (21%), Positives = 410/953 (43%), Gaps = 127/953 (13%)
Query: 502 RLSKKVEILENEIVQEKQSLQNCQ----NLSKDLMKEKAQLEKTIETLRENSERQIKILE 557
R +K++ LE ++ + K+ Q Q +L L K+K ++E N + + L+
Sbjct: 15 RALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVE--------NEKTEGTNLK 66
Query: 558 QENEHLNQTVSSLRQRSQ-ISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
+EN+ L + SL + Q IS E +VK E + + ++ K+E E ++ K E
Sbjct: 67 RENQRLMEICESLEKTKQKISHELQVK--ESQVNFQEGQLNSGKKQIEKLEQELKRCKSE 124
Query: 617 LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
LE ++ + A+ N + +KI +T + + S+ E K
Sbjct: 125 LERSQQAAQSADVSLNPCN--------TPQKIFTTPLTPSQYYS----GSKYEDLKEKYN 172
Query: 677 KTLDSFKNLTFQLESLE--KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK 734
K ++ K L ++++L+ K + L + + R +S+ Q + L S
Sbjct: 173 KEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNS 232
Query: 735 EQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQ 794
++ + + F + + S L I + + +++ L+ L+ +NQ
Sbjct: 233 QRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQ----LKAQNQ 288
Query: 795 TLQKNLEELKISSKRLEQLEKENKS----LEQETSQLEKDKKQL-EKENKRLRQQAEIKD 849
L+ + EL++ RL+ EKE K ++ QLEK K +L EKE + + E+
Sbjct: 289 ELRNKINELEL---RLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVR 345
Query: 850 TTLE--ENNVKIGNLEKENKTLSKEIGIYKESCV--------RLKELEKENKELVKRATI 899
TT + + + K LE++ K L++++ +++ ++KE EKE +E + R
Sbjct: 346 TTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQR 405
Query: 900 DIKTL----VTLREDLVSEKLKTQQMNN----DLEKLTHELEKIGLN----KERLLHDEQ 947
+TL + ++ L E + + M+N +L+KLT +++ N K++L EQ
Sbjct: 406 SFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQ 465
Query: 948 S--------TDDRYKLLESKLESTLKKS-LEIKEEKIAALEARLE---ESTNYNQQLRQE 995
+ + R + E K E+ L KS E K ++ LEA L+ + N +Q +E
Sbjct: 466 AFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE 525
Query: 996 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE----RESQETTRELLK--------V 1043
+K + E + R +E++ Q ++ E K + ++ +++LLK +
Sbjct: 526 MKAKNTSQETML-RDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQL 584
Query: 1044 KDRLIEVERNNATLQAEKQALKTQLKQLE----------TQNNNLQAQILALQRQTVSLQ 1093
D+L + E+ + L + + K + ++L+ ++N L Q ++ + +LQ
Sbjct: 585 NDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQ---MESEKENLQ 641
Query: 1094 EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1153
+ L+T Q+++ N + +L L ++ +L N +S E E K Y
Sbjct: 642 SKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYM 701
Query: 1154 SLIKDHEKLELLHERQASEYESLISKH----GTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1209
L +K E ++ E E++ K G ++ L++ ++ D+
Sbjct: 702 EL---QQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHA 758
Query: 1210 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1269
+ E L +LK ++ L+ N++H+ + + ++H+++ ++ E + ++
Sbjct: 759 EYESLRDLLK-SKDASLVTNEDHQRSLLAFD----QQPAMHHSFANIIGEQGSMPSERSE 813
Query: 1270 LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEE-----ENR 1324
+ + S L+ L+ + ++ L QCE L Q+KG +EE E
Sbjct: 814 CRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQM 873
Query: 1325 HLLDQIQTLM----LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE 1373
H +T LQ T QN+ ++ L +E ++ EL+ +K+E
Sbjct: 874 HQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKE-----KELQLLNDKVE 921
Score = 134 bits (337), Expect = 8e-31
Identities = 302/1532 (19%), Positives = 626/1532 (40%), Gaps = 244/1532 (15%)
Query: 140 EFIERIQGLDFDTKAA--VAAHIQEVTHNQENVFDL-------QWMEVTDMSQED--IEP 188
E +RI L DT A V A N+E L + E+ ++ + + +E
Sbjct: 880 ETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLED 939
Query: 189 LLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQH 248
LK + L + L E+ E S I E + L + M + +
Sbjct: 940 SLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSES 999
Query: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQEL----EQMEIELKRLQQENMNL---LSD 301
+ + + + I L + +++ LL +E E + + K Q++N L L++
Sbjct: 1000 FANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNE 1059
Query: 302 ARS-ARMYRDELDALREKAVR-----VDKLESEVSRYKERLHDIEFYKARVEELKEDNQ- 354
S ++EL+ L+E + + KL R + + ++E + + DNQ
Sbjct: 1060 CTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQN 1119
Query: 355 --------VLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE 406
+ E T+ E+Q + + +D L E E+ +K K +E + R ++
Sbjct: 1120 NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVK 1179
Query: 407 ELMEEN--------MTLEMAQKQSMDESLHLGWELEQISRTSEL----SEAPQKSLGHEV 454
E E M LE+ ++ S+D +LE + R EL SE ++ L HE+
Sbjct: 1180 ERESERNQCNFKPQMDLEV-KEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHEL 1238
Query: 455 N----ELTSSRLLKLEMENQSLTKTVE------------ELRTTV-DSVEGNASKILKME 497
+L +S L ++ + S K E EL T+ D+ S M
Sbjct: 1239 QTIRGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMN 1298
Query: 498 KENQRLSKKVEILENE----IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRE------ 547
K N+ L K EIL+ E + + S C ++ + +E +L ++ L +
Sbjct: 1299 KLNE-LEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLH 1357
Query: 548 ----------------NSERQIKI--LEQENEHLNQTVSSLRQRSQISA-EARVKDIEKE 588
N + + + L++ N + + T+S + + + + ++ E
Sbjct: 1358 GELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSE 1417
Query: 589 NKILHESIKETSSKLSKIEFEKRQIKKE-------LEHYKEKGERAEELENELHH----- 636
+KILH+ + SSK+S+++ +K E L +++ G+ +E++ L
Sbjct: 1418 HKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQ--GDLVKEMQLGLEEGLVPS 1475
Query: 637 ------------------------LEKENELLQKKITNLK--ITCEKIEALEQENSELER 670
LE+ ++ ++NL+ ++ + E S L+
Sbjct: 1476 LSSSCVPDSSSLSSLGDSSFYRALLEQTGDM--SLLSNLEGAVSANQCSVDEVFCSSLQE 1533
Query: 671 ENRKLKKTLDSFKNLTFQLESL--------EKENSQLDEENLELRRNVESLK-CASMKMA 721
EN K+T + +LESL EK +++ + + + ++ L+ S +
Sbjct: 1534 ENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQ 1593
Query: 722 QLQLENKELESEKEQLKKGL--------ELLKASFKKTERLEVSYQGLDIENQRLQ-KTL 772
+L K+ SE EQ ++ L L A K+TE+L L++E RLQ + L
Sbjct: 1594 ELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLS-----LELEVARLQLQGL 1648
Query: 773 ENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL-EKDK 831
+ S++ + +++E +Q E IS + E ++ + + Q+ +KD
Sbjct: 1649 DLSSRSLLGIDTE--------DAIQGRNESCDISKEHTS--ETTERTPKHDVHQICDKDA 1698
Query: 832 KQ-LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
+Q L + +++ + +K T E + + + E K G C+ N
Sbjct: 1699 QQDLNLDIEKITETGAVKPTG-ECSGEQSPDTNYEPPGEDKTQG--SSECISELSFSGPN 1755
Query: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
A + + L +ED+ + +L+ ++ +N+ +L H +E E LL++ + D
Sbjct: 1756 ------ALVPMDFLGN-QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELD 1808
Query: 951 DRYKLLESKLESTLKKSLEIKE------EKIAALEARLEESTNYNQQLRQELKTVKKNYE 1004
+ L E +L + ++ +E+++ ++ + L +LE + +Q+L Q ++T +
Sbjct: 1809 SKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNS 1868
Query: 1005 ALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQAL 1064
L+ D+ ++ ++ W+ + EL +++ +E L+A+ + +
Sbjct: 1869 DLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVV 1928
Query: 1065 KTQLKQLETQNNNLQAQILALQRQ-TVSLQEQN-------------TTLQTQNAKLQVEN 1110
+T+ LE N N Q I+ L+ + +V E+N T L + K++ +
Sbjct: 1929 QTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKT 1988
Query: 1111 STLNSQSTSLMN--QNAQLLIQQ-----SSLENENESVIKEREDLKSLYDSLIKDHEKLE 1163
L S + ++ Q A+ +++ +L ++ ++K++ L+ SL KD + L
Sbjct: 1989 QELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALS 2048
Query: 1164 LLH---ERQAS----EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL----- 1211
L E Q + E E L+ + +L++ + E ++ L +KG+
Sbjct: 2049 LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLS 2108
Query: 1212 ---EDLEKMLK-VEQEKMLLE--NKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1265
E++ ++ + +E+ ++ +E K +A + K+ END L L +E ++ +
Sbjct: 2109 STQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEE 2168
Query: 1266 DHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1325
+ + + NSK E L+ + ++ + ++ L ++ E L++ +E +
Sbjct: 2169 NQELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTK----QIQEKQG 2224
Query: 1326 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL-NELRRQKEKLEEKIMDQ--YKF 1382
L ++ L+ ++LLE+ +++ E + ++ L N+L+ E + DQ K
Sbjct: 2225 QLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKA 2284
Query: 1383 YDPS--PP-----RRRGNWITLKMRKLIKSKKDI-----NRERQKSLTLTPTRSDSSEGF 1430
+ S PP + R + L+ R KK + +E + L R ++ E
Sbjct: 2285 TEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERE 2344
Query: 1431 LQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSM 1462
L++ + + ++ NS + +TL K M
Sbjct: 2345 LEIARTNQEHAALEAENSKGEVETLKAKIEGM 2376
Score = 95.1 bits (235), Expect = 6e-19
Identities = 189/895 (21%), Positives = 348/895 (38%), Gaps = 145/895 (16%)
Query: 716 ASMKMAQLQLENKELESEKEQLKKGLELLKASFKK----TERLEVSYQGLDIENQRLQKT 771
A K+ +L+ + +L+ EK+Q + L+ L+A+ +K E + L ENQRL +
Sbjct: 16 ALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLMEI 75
Query: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKISS--KRLEQLEKENKSLEQETSQLEK 829
E+ K Q++ ELQ E Q N +E +++S K++E+LE+E K + E + ++
Sbjct: 76 CESLEKTKQKISHELQVKES-----QVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQ 130
Query: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE 889
+ + +I T L + G+ ++ K Y + K LE E
Sbjct: 131 AAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEK------YNKEVEERKRLEAE 184
Query: 890 NKEL-VKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELE--------KIGLNKE 940
K L K+A+ + D+ + + + EK L + +
Sbjct: 185 VKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSAS 244
Query: 941 RLLHDEQSTDDRYKLLESKLEST---------------LKKSLEIKEEKIAALEARLE-- 983
+++ T R L K ++ LK + KI LE RL+
Sbjct: 245 YFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGH 304
Query: 984 -----ESTNYNQQLRQELKTVK----KNYEALKQRQDE-----ERMVQSSPPISG----- 1024
N Q+L+ +L+ K + + L + +DE + Q+S +
Sbjct: 305 EKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKL 364
Query: 1025 ----EDNKWERESQETTRELLKVK---------DRLIEVERNNATLQAE----KQALKTQ 1067
ED +R++ E+ R L+ K + L +R+ TL E K L +
Sbjct: 365 KKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQE 424
Query: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
L+Q + +N LQA++ L +V Q +N + + + E + SQ
Sbjct: 425 LQQAKNMHNVLQAELDKL--TSVKQQLENNLEEFKQKLCRAEQAFQASQ----------- 471
Query: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKD--HEKLELLHERQASEYESLISKHGTLKS 1185
I+++ L E + KE LKS + ++ H + EL + +Q ++ +K+
Sbjct: 472 -IKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEE--MKA 528
Query: 1186 AHKNLEVEHRDLEDRYNQ------LLKQKGQLEDLEKMLKVEQEKMLLENKNH------- 1232
+ + E RDL+++ NQ L K K + DLEK Q+ LL+ + H
Sbjct: 529 KNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQD--LLKKREHHIEQLND 586
Query: 1233 --ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1290
E K L + Y +L +E + + LL + E+ L+++ +
Sbjct: 587 KLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINH 646
Query: 1291 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL------LEQN 1344
L+ + I S + N + L + NL E R+L + + + ++ T L+Q
Sbjct: 647 LETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQK 706
Query: 1345 MESKDLFH--------VEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWIT 1396
E D H ++ Q ++ +L + + L +IMD+ + Y
Sbjct: 707 AEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYE----- 761
Query: 1397 LKMRKLIKSKKD---INRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQ 1453
+R L+KSK N + Q+SL + F + + S LE Q
Sbjct: 762 -SLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQ 820
Query: 1454 TLGTKKSSMVALKRLPFLR-----NRPKDKDKMKACYRRSMSMNDLVQSMVLAGQ 1503
+ K+S + R+ L + + D K C ++ ++++ A Q
Sbjct: 821 ---SPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQ 872
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 197 bits (500), Expect = 1e-49
Identities = 263/1120 (23%), Positives = 501/1120 (44%), Gaps = 163/1120 (14%)
Query: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
++ R +E++ K ++L K+ ++ E ELK L+Q++ L + + +++L A E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQEQLQAETEL 902
Query: 319 AVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVL-LETKTM------LEDQLEGT 370
+++ ++ K+ L +I +AR+EE ++ Q L E K M LE+QLE
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 371 RARSDKLHELEKENLQLKAK--------LHDMEMERDMDRKKIEE--------LMEE--- 411
A KL +LEK + K K + D + +RK +EE L EE
Sbjct: 963 EAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 412 --NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG-----HEVNELTSSRLLK 464
N+T + +SM L + + E+ SR EL + +K G HE +++ +
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
L+M+ L K EEL+ + ++ ++ K+ + L + L+ ++ E+ +
Sbjct: 1081 LKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 525 QNLSKDLMKE----KAQLEKTIET------LRENSERQI----KILEQENEHLNQTVSSL 570
+ +DL +E K +LE T+++ LR E+++ K L++E V +
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 571 RQ-----------------RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
RQ R++ + + + +EKEN L ++ ++E +K+++
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 614 KKELEHYKEK---GERAE-ELENELHHLEKENELLQKKITNLKITCEKI-EALEQENSEL 668
+ +++ + K GERA EL +++H L+ E E + + + K+ + + +S+L
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 669 ERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEENLELRRNVE--------SLKCA 716
+ L++ N++ +L LE+E + QLDEE +E ++N+E L +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE-MEAKQNLERHISTLNIQLSDS 1376
Query: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
K+ + LE K++ +K +E L + E +Y L+ RLQ+ L++
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQY---EEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 777 KKIQQLESELQDLEMENQTLQKNL-EELKISSK--------RLEQLEKENK--SLEQETS 825
+ + +LE + + + L EE ISSK E EKE K SL +
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
+ + K++LE+ NK L+ + E ++ ++ + LEK + L ++ +E +L+E
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM---EEMKTQLEE 1550
Query: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945
LE E +AT D K LR ++ + LK Q DL+ + E+ +R LH+
Sbjct: 1551 LEDE-----LQATEDAK----LRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 946 -EQSTDDRYK------LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998
E +D K + KLE L K LE++ + +A++ R EE+ ++L+ ++K
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDL-KDLELQAD--SAIKGR-EEAIKQLRKLQAQMKD 1656
Query: 999 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1058
++ E + +DE I + E++++ +L+++++ L ER
Sbjct: 1657 FQRELEDARASRDE---------IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 1059 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ-------------TQNAK 1105
EK+ L +L + N LQ + L+ + L+E+ Q TQ A+
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 1106 LQVENSTLNSQSTSLMNQNAQLLIQQSSLE-----NENESVIKEREDLKSLYDSLIKDHE 1160
Q+ N +ST+ N++A+ +++ + E +E E +K + KS +L
Sbjct: 1768 -QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK--FKSTIAALEAKIA 1824
Query: 1161 KLELLHERQASEYE----SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1216
+LE E++A E + SL K LK +E E + E Q K +++ L++
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 1217 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1256
L+ +E+ N N + E + N+ + + L
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
Score = 183 bits (464), Expect = 2e-45
Identities = 234/1094 (21%), Positives = 470/1094 (42%), Gaps = 141/1094 (12%)
Query: 364 EDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
ED+L+ T+ R K L ELE+++ QL + + ++ + + + E E + L A+
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA-AK 916
Query: 420 KQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
KQ ++E LH + LE+ + +A +K + ++ +L +LE E + K E
Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE----QLEEEEAARQKLQLE 972
Query: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
T ++ +IL M+ +N +LSK+ ++LE I +L + +K+L K K +
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 539 EKTIETL----------RENSERQIKILEQENEHLNQTVSSLRQR--------------- 573
E I L R+ E+ + LE + ++ ++ L+ +
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092
Query: 574 ------------SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621
+ +A +++++E L E + + +K E +KR + +ELE K
Sbjct: 1093 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 622 EKGERAEELENELHHLEKENELLQKK---ITNLKITCEKIEALEQENSELERENRKLK-K 677
ELE+ L + EL K+ +T LK +AL++E E + ++++ K
Sbjct: 1153 ------TELEDTLDSTATQQELRAKREQEVTVLK------KALDEETRSHEAQVQEMRQK 1200
Query: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
+ + LT QLE ++ + LD+ L + L + ++ L +E+E +K++L
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKL 1257
Query: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN--------------KKIQQLE 783
+ ++ L++ ER L+ + +LQ +E+ K + L
Sbjct: 1258 EAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 784 SELQDLE--MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
S+LQD + ++ +T QK L +S+K L QLE+E SL+ + + + K+ LE+ L
Sbjct: 1315 SQLQDTQELLQEETRQK----LNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRA 897
Q L++ + LE+ K KEI Y+E +LEK L +
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLE 957
+DLV + +Q+ ++LEK + ++LL +E++ +Y
Sbjct: 1430 -----------DDLVVDLDNQRQLVSNLEKKQRKF-------DQLLAEEKNISSKYADER 1471
Query: 958 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1017
+ E+ ++ KE K +L LEE+ ++L + K +K E L +D+ + +
Sbjct: 1472 DRAEAEARE----KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD--VGK 1525
Query: 1018 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL--------K 1069
+ + E + +E +L +++D L E L+ QALK Q +
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585
Query: 1070 QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI 1129
Q E + LQ Q+ + + ++Q KL+ + L Q+ S + + +
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 1130 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1189
Q L+ + + +E ED ++ D + ++ E + ++ L + A K
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 1190 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE----QEKMLLENKNHETVAAEYKKLCGE 1245
++E +L + L + L+D ++ L+ +E++ E N E ++ +K +
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 1246 NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE----AEFSKLKEQYQQLDIT 1301
++L+ ++L E Q + + L +K +++L A SK K L+
Sbjct: 1766 AEQLS---NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 1302 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1361
+L Q E ++ K + + +++ ++LQ +E + + + + + +
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNAR 1878
Query: 1362 LNELRRQKEKLEEK 1375
+ +L+RQ E+ EE+
Sbjct: 1879 VKQLKRQLEEAEEE 1892
Score = 181 bits (459), Expect = 6e-45
Identities = 228/958 (23%), Positives = 429/958 (44%), Gaps = 102/958 (10%)
Query: 198 KRLIDER-DEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256
++L++ER + + + E E+ L L + S S K +SRQ L
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE------ 1054
Query: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
K K R+L + + EQ+ D + ++ +++++L + ++E A AR+ DE+
Sbjct: 1055 KLK-RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAALARL-DDEIAQKN 1107
Query: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-KTMLEDQLEGTRARSD 375
++ +LE +S +E L + + E+ K D LE KT LED L+ T + +
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 376 KLHELEKENLQLKAKL------HDMEME--RDMDRKKIEELMEENMTLEMAQ------KQ 421
+ E+E LK L H+ +++ R + +EEL E+ + A+ KQ
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 422 SMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
+++ E+ L EL + + + E +K L +V EL S+ E L V +L+
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-QSKCSDGERARAELNDKVHKLQ 1286
Query: 481 TTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
V+SV G + K +K+ K+ LS +++ + + +E + N + L +E+
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 537 QLEKTIET---LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
L+ ++ ++N ER I L + + + + E + K +KE + L
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK-KRFQKEIENLT 1405
Query: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE--LLQKKITNL 651
+ +E ++ K+E K ++++EL+ + +L + L +++ + L ++K +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
K E+ A E E E E + L + L+ E LE+ N L E +L V
Sbjct: 1466 KYADERDRA-EAEAREKETKALSLARALEEALEAK---EELERTNKMLKAEMEDL---VS 1518
Query: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE----RLEVSYQGLDIENQR 767
S + +L+ + LE++ E++K LE L+ + TE RLEV+ Q L + +R
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 768 -LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE--------QLEKENK 818
LQ E + +K +QL+ +L + E E + +K + K+LE Q + K
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKD---TTLEENNVKIGNLEKENKTLSKEIGI 875
E+ QL K + Q++ + L +D T +EN K +LE + L +++
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 876 YKESCVRLKELEKEN--KELV-----KRATIDIKT-----LVTLREDLVSEKLKTQQMNN 923
E + +LEKE +EL + A D K + L E+L E+ + M++
Sbjct: 1699 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 924 DLEKLTHELEKIG--LNKERLLH----------DEQSTDDRYKL--LESKLESTLKKSLE 969
+ K T + E++ L ER + Q+ + R KL +E ++S K ++
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 970 IKEEKIAALEARLEESTNYNQQLRQELKTV-KKNYEALKQRQDEERMVQSSPPISGEDNK 1028
E KIA LE ++E+ Q + LK KK E L Q +DE +M + +
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE----------Q 1867
Query: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1086
++ ++++ + ++K +L E E + + A ++ L+ +L + N + ++ AL+
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1925
Score = 149 bits (376), Expect = 2e-35
Identities = 203/846 (23%), Positives = 361/846 (42%), Gaps = 98/846 (11%)
Query: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
EE++ + L+K E QK LK LEQ++S+L E L++ L + L
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELK-------ELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 688 QLES----LEKENSQLDEENLELRRNVES-------LKCASMKMAQLQLENKELESEKEQ 736
+ E L + +L+E E+ +E L+ KMAQ L+ +E E+E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 737 LKKGLELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE--MEN 793
++ L+L K + + K ++LE +D +N +L K + ++I L + L + E +N
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 794 QTLQKNLEELKISSK--RLEQLEKENKSLEQETSQLEKD------------------KKQ 833
T KN E IS RL++ EK + LE+ +LE D K Q
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 834 LEKENKRLRQQ-AEIKDTTLEENNV--KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
L K+ + L+ A + D ++NN KI LE L +++ E R K EK+
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--SERAARNKA-EKQK 1141
Query: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
++L + +++ L T ED + Q++ E+ L+K L++E H+ Q +
Sbjct: 1142 RDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQE 1196
Query: 951 DRYKLLESKLEST--------LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKN 1002
R K ++ E T K +L+ ++ + A L Q +QE++ KK
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 1003 YEALKQR-----QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1057
EA Q D ER + ++ + +K + E + T L + + + I++ ++ A+L
Sbjct: 1257 LEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 1058 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1117
++ Q + L++ Q N+ ++ L+ + SLQ+Q L+ STLN Q
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 1118 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1177
+ + +LE + KE E+L Y+ ++KLE R E + L+
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 1178 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1237
+ NLE + R +++QLL ++ +++ E+++ E + ET A
Sbjct: 1434 VDLDNQRQLVSNLEKKQR----KFDQLLAEE---KNISSKYADERDRAEAEAREKETKAL 1486
Query: 1238 EYKKLCGE----NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1293
+ E + L T L E E L + ++ ++ + + LE + ++K
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 1294 QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV 1353
Q ++L+ ++ + K LE + L Q + LQ R EQN E +
Sbjct: 1547 QLEELE-------DELQATEDAKLRLEVNMQALKGQFER-DLQARD--EQNEEKRRQLQR 1596
Query: 1354 EQRQYIDKLNELRRQ-------KEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSK 1406
+ +Y +L + R+Q K+KLE + D D + R ++RKL
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQM 1654
Query: 1407 KDINRE 1412
KD RE
Sbjct: 1655 KDFQRE 1660
Score = 142 bits (357), Expect = 4e-33
Identities = 186/934 (19%), Positives = 405/934 (43%), Gaps = 82/934 (8%)
Query: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENE 561
R ++++ E+E+ + K+ Q +N K+L ++ +QL + L+E + + ++ + E
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 562 HLNQTVSSLRQRSQI--SAEARVKDIEKENKILHESIKETSSKLSKIE---FEKRQIKKE 616
+ + ++ +I EAR+++ E + L K+ + ++ +E E+ +++
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 617 LEHYKEKGE-RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
L+ K E + ++LE+E+ ++ +N L K+ K+ E+I L +E E + + L
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNL 1025
Query: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE-------------SLKCASMKMAQ 722
K + +++ +LE K+ + +E +L+R +E + A +KM Q
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM-Q 1084
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL--DIENQRLQKTLENSNKKIQ 780
L + +EL++ +L + + KK LE L D++++R + + K+ +
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR--NKAEKQKR 1142
Query: 781 QLESELQDLEME-NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
L EL+ L+ E TL + ++ +KR +++ K+L++ET E Q+++ +
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQ 1199
Query: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE----------IGIYKESCV-RLKELEK 888
+ Q E LE+ NL+K +TL KE +G K+ + K+LE
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948
+ +EL + + + L + K ++ N++E +T L + +L D S
Sbjct: 1260 QVQELQSKCSDGERARAELND-------KVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 949 ----TDDRYKLLESKLESTLKKSLEIK--EEKIAALEARLEESTNYNQQLRQELKTVK-K 1001
D +LL+ + L S +++ EE+ +L+ +L+E Q L + + T+ +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 1002 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
++ K+ QD V++ + ++++E + T++ + ++E+ LQ E
Sbjct: 1373 LSDSKKKLQDFASTVEA---LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
L L +NL+ + + + ++ + + + E +++ SL
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489
Query: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYD-------SLIKDHEKLELLHERQASEYE 1174
+ L + LE N+ + E EDL S D L K LE E ++ E
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549
Query: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED-----LEKMLKVEQEKMLLEN 1229
L + + A LEV + L+ ++ + L+ + + + L++ L + ++ E
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 1230 KNHETVAAEYKKLCG-------ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1282
K AA KKL G + D + +K+ LQ K+ + L +++ +
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 1283 RLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
+ A + +++ + L+ +L + + + E L +++ + L R L+
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-SLSGRNALQ 1728
Query: 1343 QNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
+ K Q ++L E + E + +++
Sbjct: 1729 ---DEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Score = 134 bits (338), Expect = 6e-31
Identities = 154/767 (20%), Positives = 336/767 (43%), Gaps = 79/767 (10%)
Query: 136 QKKEEFIERI-QGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMA 194
QK + +E + + L+ +A + T +EN + V +++++E K +
Sbjct: 1199 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1258
Query: 195 LHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
++ L + + EL+ D +H L + S K + L+ ++A
Sbjct: 1259 AQVQELQSKCSDGERARAELN---DKVHKLQNEVESVTGMLNEAEGKAIK----LAKDVA 1311
Query: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
++++ ++ L+E+T Q L+ +L Q+E E LQ + +E++A
Sbjct: 1312 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-------------LDEEMEA 1358
Query: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
+ + L ++S K++L D + + VE L+E + + L Q E A
Sbjct: 1359 KQNLERHISTLNIQLSDSKKKLQD---FASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE 434
DKL EK +L+ +L D+ ++ D R+ + L ++ + + + S E +
Sbjct: 1416 DKL---EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 435 QISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494
+ + E SL + E ++ +LE N+ L +E+L ++ D V N +
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKN---VH 1528
Query: 495 KMEKENQRLSKKVEILENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETLRE-NS 549
++EK + L ++E ++ ++ + + LQ ++ L ++ K Q E+ ++ E N
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1588
Query: 550 ERQIKILEQENEHLNQTVSSLRQRSQISA-----EARVKDIEKENKILHESIKETSSKLS 604
E++ ++ Q +E+ + +QR+ +A E +KD+E + + +E +L
Sbjct: 1589 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1648
Query: 605 KIEFEKRQIKKELEHY-----------KEKGERAEELENELHHLEKENELLQKKITNLKI 653
K++ + + ++ELE KE ++A+ LE +L L+++ ++ +
Sbjct: 1649 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1708
Query: 654 TCEKI-----------EALEQENSELERENRKLKKTLDSFK-NLTFQLESLEKENSQLDE 701
E++ AL+ E LE +L++ L+ + N+ + + K Q ++
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT--------ER 753
+ EL + + QL+ +NKEL S+ +++ + K+ FK T +
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV---KSKFKSTIAALEAKIAQ 1825
Query: 754 LEVSYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMENQTLQKNLEELKISSKR 809
LE + E Q K+L+ +KK++ Q+E E + E + +K +K ++
Sbjct: 1826 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1885
Query: 810 LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENN 856
LE+ E+E++ + +L+++ + + N+ + ++ + L N
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1932
Score = 131 bits (329), Expect = 7e-30
Identities = 180/799 (22%), Positives = 351/799 (43%), Gaps = 118/799 (14%)
Query: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK----EQLKKGLELL 744
L + ++ ++ + EL++ E + A ++ +L+ ++ +L EK EQL+ EL
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
+ + RL Q L+ ++ LE + QQL++E + + + L++ LEE +
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 805 ISSKRLEQLEK-----ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
+ ++L QLEK + K LE E ++ +L KE K L ++ T L E K
Sbjct: 964 AARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK-------------------RATI- 899
NL K +K + E VRLK+ EK +EL K +A I
Sbjct: 1023 KNL---TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 900 DIKTLVTLREDLVSEKL-----KTQQMNNDLEKLTHELE------KIGLNKERLLH---D 945
++K + +E+ + L + Q NN L+K+ ELE + L+ ER +
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSERAARNKAE 1138
Query: 946 EQSTD--DRYKLLESKLESTL-----KKSLEIK-EEKIAALEARLEESTNYNQQLRQELK 997
+Q D + + L+++LE TL ++ L K E+++ L+ L+E T ++ QE++
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 998 TVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
+K+ +A+++ ++ E+ ++ + E+E+ + EL + EVE
Sbjct: 1199 --QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
L+A+ Q L+++ E L ++ LQ + S+ + + KL + ++L+SQ
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 1117 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1176
Q+ Q L+Q+ + + N S KL L E + S + L
Sbjct: 1317 L-----QDTQELLQEETRQKLNVST-------------------KLRQLEEERNSLQDQL 1352
Query: 1177 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1236
+ A +NLE R + QL K +L+D ++ +E K E +
Sbjct: 1353 DEE----MEAKQNLE---RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 1237 AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE---AEFSKLKE 1293
+Y++ D+L T ++L +E + L D N + L++N + +Q + + AE +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 1294 QY-----------QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
+Y ++ + + L E + K LE N+ L +++ L+ +
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-- 1523
Query: 1343 QNMESKDLFHVE--QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK-- 1398
K++ +E +R ++ E++ Q E+LE D+ + + + R N LK
Sbjct: 1524 ----GKNVHELEKSKRALETQMEEMKTQLEELE----DELQATEDAKLRLEVNMQALKGQ 1575
Query: 1399 MRKLIKSKKDINRERQKSL 1417
+ ++++ + N E+++ L
Sbjct: 1576 FERDLQARDEQNEEKRRQL 1594
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 197 bits (500), Expect = 1e-49
Identities = 263/1120 (23%), Positives = 501/1120 (44%), Gaps = 163/1120 (14%)
Query: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
++ R +E++ K ++L K+ ++ E ELK L+Q++ L + + +++L A E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQEQLQAETEL 909
Query: 319 AVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVL-LETKTM------LEDQLEGT 370
+++ ++ K+ L +I +AR+EE ++ Q L E K M LE+QLE
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 371 RARSDKLHELEKENLQLKAK--------LHDMEMERDMDRKKIEE--------LMEE--- 411
A KL +LEK + K K + D + +RK +EE L EE
Sbjct: 970 EAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 412 --NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG-----HEVNELTSSRLLK 464
N+T + +SM L + + E+ SR EL + +K G HE +++ +
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
L+M+ L K EEL+ + ++ ++ K+ + L + L+ ++ E+ +
Sbjct: 1088 LKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 525 QNLSKDLMKE----KAQLEKTIET------LRENSERQI----KILEQENEHLNQTVSSL 570
+ +DL +E K +LE T+++ LR E+++ K L++E V +
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 571 RQ-----------------RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
RQ R++ + + + +EKEN L ++ ++E +K+++
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 614 KKELEHYKEK---GERAE-ELENELHHLEKENELLQKKITNLKITCEKI-EALEQENSEL 668
+ +++ + K GERA EL +++H L+ E E + + + K+ + + +S+L
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 669 ERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEENLELRRNVE--------SLKCA 716
+ L++ N++ +L LE+E + QLDEE +E ++N+E L +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE-MEAKQNLERHISTLNIQLSDS 1383
Query: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
K+ + LE K++ +K +E L + E +Y L+ RLQ+ L++
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQY---EEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 777 KKIQQLESELQDLEMENQTLQKNL-EELKISSK--------RLEQLEKENK--SLEQETS 825
+ + +LE + + + L EE ISSK E EKE K SL +
Sbjct: 1441 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
+ + K++LE+ NK L+ + E ++ ++ + LEK + L ++ +E +L+E
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM---EEMKTQLEE 1557
Query: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945
LE E +AT D K LR ++ + LK Q DL+ + E+ +R LH+
Sbjct: 1558 LEDE-----LQATEDAK----LRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 946 -EQSTDDRYK------LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998
E +D K + KLE L K LE++ + +A++ R EE+ ++L+ ++K
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDL-KDLELQAD--SAIKGR-EEAIKQLRKLQAQMKD 1663
Query: 999 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1058
++ E + +DE I + E++++ +L+++++ L ER
Sbjct: 1664 FQRELEDARASRDE---------IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 1059 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ-------------TQNAK 1105
EK+ L +L + N LQ + L+ + L+E+ Q TQ A+
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 1106 LQVENSTLNSQSTSLMNQNAQLLIQQSSLE-----NENESVIKEREDLKSLYDSLIKDHE 1160
Q+ N +ST+ N++A+ +++ + E +E E +K + KS +L
Sbjct: 1775 -QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK--FKSTIAALEAKIA 1831
Query: 1161 KLELLHERQASEYE----SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1216
+LE E++A E + SL K LK +E E + E Q K +++ L++
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 1217 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1256
L+ +E+ N N + E + N+ + + L
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
Score = 183 bits (464), Expect = 2e-45
Identities = 234/1094 (21%), Positives = 470/1094 (42%), Gaps = 141/1094 (12%)
Query: 364 EDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
ED+L+ T+ R K L ELE+++ QL + + ++ + + + E E + L A+
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA-AK 923
Query: 420 KQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
KQ ++E LH + LE+ + +A +K + ++ +L +LE E + K E
Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE----QLEEEEAARQKLQLE 979
Query: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
T ++ +IL M+ +N +LSK+ ++LE I +L + +K+L K K +
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 539 EKTIETL----------RENSERQIKILEQENEHLNQTVSSLRQR--------------- 573
E I L R+ E+ + LE + ++ ++ L+ +
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099
Query: 574 ------------SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621
+ +A +++++E L E + + +K E +KR + +ELE K
Sbjct: 1100 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 622 EKGERAEELENELHHLEKENELLQKK---ITNLKITCEKIEALEQENSELERENRKLK-K 677
ELE+ L + EL K+ +T LK +AL++E E + ++++ K
Sbjct: 1160 ------TELEDTLDSTATQQELRAKREQEVTVLK------KALDEETRSHEAQVQEMRQK 1207
Query: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
+ + LT QLE ++ + LD+ L + L + ++ L +E+E +K++L
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKL 1264
Query: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN--------------KKIQQLE 783
+ ++ L++ ER L+ + +LQ +E+ K + L
Sbjct: 1265 EAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 784 SELQDLE--MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
S+LQD + ++ +T QK L +S+K L QLE+E SL+ + + + K+ LE+ L
Sbjct: 1322 SQLQDTQELLQEETRQK----LNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRA 897
Q L++ + LE+ K KEI Y+E +LEK L +
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLE 957
+DLV + +Q+ ++LEK + ++LL +E++ +Y
Sbjct: 1437 -----------DDLVVDLDNQRQLVSNLEKKQRKF-------DQLLAEEKNISSKYADER 1478
Query: 958 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1017
+ E+ ++ KE K +L LEE+ ++L + K +K E L +D+ + +
Sbjct: 1479 DRAEAEARE----KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD--VGK 1532
Query: 1018 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL--------K 1069
+ + E + +E +L +++D L E L+ QALK Q +
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 1070 QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI 1129
Q E + LQ Q+ + + ++Q KL+ + L Q+ S + + +
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 1130 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1189
Q L+ + + +E ED ++ D + ++ E + ++ L + A K
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 1190 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE----QEKMLLENKNHETVAAEYKKLCGE 1245
++E +L + L + L+D ++ L+ +E++ E N E ++ +K +
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 1246 NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE----AEFSKLKEQYQQLDIT 1301
++L+ ++L E Q + + L +K +++L A SK K L+
Sbjct: 1773 AEQLS---NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 1302 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1361
+L Q E ++ K + + +++ ++LQ +E + + + + + +
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNAR 1885
Query: 1362 LNELRRQKEKLEEK 1375
+ +L+RQ E+ EE+
Sbjct: 1886 VKQLKRQLEEAEEE 1899
Score = 181 bits (459), Expect = 6e-45
Identities = 228/958 (23%), Positives = 429/958 (44%), Gaps = 102/958 (10%)
Query: 198 KRLIDER-DEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256
++L++ER + + + E E+ L L + S S K +SRQ L
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE------ 1061
Query: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
K K R+L + + EQ+ D + ++ +++++L + ++E A AR+ DE+
Sbjct: 1062 KLK-RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAALARL-DDEIAQKN 1114
Query: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-KTMLEDQLEGTRARSD 375
++ +LE +S +E L + + E+ K D LE KT LED L+ T + +
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 376 KLHELEKENLQLKAKL------HDMEME--RDMDRKKIEELMEENMTLEMAQ------KQ 421
+ E+E LK L H+ +++ R + +EEL E+ + A+ KQ
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 422 SMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
+++ E+ L EL + + + E +K L +V EL S+ E L V +L+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-QSKCSDGERARAELNDKVHKLQ 1293
Query: 481 TTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
V+SV G + K +K+ K+ LS +++ + + +E + N + L +E+
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 537 QLEKTIET---LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
L+ ++ ++N ER I L + + + + E + K +KE + L
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK-KRFQKEIENLT 1412
Query: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE--LLQKKITNL 651
+ +E ++ K+E K ++++EL+ + +L + L +++ + L ++K +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
K E+ A E E E E + L + L+ E LE+ N L E +L V
Sbjct: 1473 KYADERDRA-EAEAREKETKALSLARALEEALEAK---EELERTNKMLKAEMEDL---VS 1525
Query: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE----RLEVSYQGLDIENQR 767
S + +L+ + LE++ E++K LE L+ + TE RLEV+ Q L + +R
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 768 -LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE--------QLEKENK 818
LQ E + +K +QL+ +L + E E + +K + K+LE Q + K
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKD---TTLEENNVKIGNLEKENKTLSKEIGI 875
E+ QL K + Q++ + L +D T +EN K +LE + L +++
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 876 YKESCVRLKELEKEN--KELV-----KRATIDIKT-----LVTLREDLVSEKLKTQQMNN 923
E + +LEKE +EL + A D K + L E+L E+ + M++
Sbjct: 1706 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 924 DLEKLTHELEKIG--LNKERLLH----------DEQSTDDRYKL--LESKLESTLKKSLE 969
+ K T + E++ L ER + Q+ + R KL +E ++S K ++
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 970 IKEEKIAALEARLEESTNYNQQLRQELKTV-KKNYEALKQRQDEERMVQSSPPISGEDNK 1028
E KIA LE ++E+ Q + LK KK E L Q +DE +M + +
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE----------Q 1874
Query: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1086
++ ++++ + ++K +L E E + + A ++ L+ +L + N + ++ AL+
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALK 1932
Score = 149 bits (376), Expect = 2e-35
Identities = 203/846 (23%), Positives = 361/846 (42%), Gaps = 98/846 (11%)
Query: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
EE++ + L+K E QK LK LEQ++S+L E L++ L + L
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELK-------ELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 688 QLES----LEKENSQLDEENLELRRNVES-------LKCASMKMAQLQLENKELESEKEQ 736
+ E L + +L+E E+ +E L+ KMAQ L+ +E E+E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 737 LKKGLELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE--MEN 793
++ L+L K + + K ++LE +D +N +L K + ++I L + L + E +N
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 794 QTLQKNLEELKISSK--RLEQLEKENKSLEQETSQLEKD------------------KKQ 833
T KN E IS RL++ EK + LE+ +LE D K Q
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 834 LEKENKRLRQQ-AEIKDTTLEENNV--KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
L K+ + L+ A + D ++NN KI LE L +++ E R K EK+
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--SERAARNKA-EKQK 1148
Query: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
++L + +++ L T ED + Q++ E+ L+K L++E H+ Q +
Sbjct: 1149 RDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQE 1203
Query: 951 DRYKLLESKLEST--------LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKN 1002
R K ++ E T K +L+ ++ + A L Q +QE++ KK
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 1003 YEALKQR-----QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1057
EA Q D ER + ++ + +K + E + T L + + + I++ ++ A+L
Sbjct: 1264 LEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 1058 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1117
++ Q + L++ Q N+ ++ L+ + SLQ+Q L+ STLN Q
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380
Query: 1118 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1177
+ + +LE + KE E+L Y+ ++KLE R E + L+
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 1178 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1237
+ NLE + R +++QLL ++ +++ E+++ E + ET A
Sbjct: 1441 VDLDNQRQLVSNLEKKQR----KFDQLLAEE---KNISSKYADERDRAEAEAREKETKAL 1493
Query: 1238 EYKKLCGE----NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1293
+ E + L T L E E L + ++ ++ + + LE + ++K
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 1294 QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV 1353
Q ++L+ ++ + K LE + L Q + LQ R EQN E +
Sbjct: 1554 QLEELE-------DELQATEDAKLRLEVNMQALKGQFER-DLQARD--EQNEEKRRQLQR 1603
Query: 1354 EQRQYIDKLNELRRQ-------KEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSK 1406
+ +Y +L + R+Q K+KLE + D D + R ++RKL
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQM 1661
Query: 1407 KDINRE 1412
KD RE
Sbjct: 1662 KDFQRE 1667
Score = 142 bits (357), Expect = 4e-33
Identities = 186/934 (19%), Positives = 405/934 (43%), Gaps = 82/934 (8%)
Query: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENE 561
R ++++ E+E+ + K+ Q +N K+L ++ +QL + L+E + + ++ + E
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 562 HLNQTVSSLRQRSQI--SAEARVKDIEKENKILHESIKETSSKLSKIE---FEKRQIKKE 616
+ + ++ +I EAR+++ E + L K+ + ++ +E E+ +++
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 617 LEHYKEKGE-RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
L+ K E + ++LE+E+ ++ +N L K+ K+ E+I L +E E + + L
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNL 1032
Query: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE-------------SLKCASMKMAQ 722
K + +++ +LE K+ + +E +L+R +E + A +KM Q
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM-Q 1091
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL--DIENQRLQKTLENSNKKIQ 780
L + +EL++ +L + + KK LE L D++++R + + K+ +
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR--NKAEKQKR 1149
Query: 781 QLESELQDLEME-NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
L EL+ L+ E TL + ++ +KR +++ K+L++ET E Q+++ +
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQ 1206
Query: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE----------IGIYKESCV-RLKELEK 888
+ Q E LE+ NL+K +TL KE +G K+ + K+LE
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948
+ +EL + + + L + K ++ N++E +T L + +L D S
Sbjct: 1267 QVQELQSKCSDGERARAELND-------KVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 949 ----TDDRYKLLESKLESTLKKSLEIK--EEKIAALEARLEESTNYNQQLRQELKTVK-K 1001
D +LL+ + L S +++ EE+ +L+ +L+E Q L + + T+ +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 1002 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
++ K+ QD V++ + ++++E + T++ + ++E+ LQ E
Sbjct: 1380 LSDSKKKLQDFASTVEA---LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
L L +NL+ + + + ++ + + + E +++ SL
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496
Query: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYD-------SLIKDHEKLELLHERQASEYE 1174
+ L + LE N+ + E EDL S D L K LE E ++ E
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556
Query: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED-----LEKMLKVEQEKMLLEN 1229
L + + A LEV + L+ ++ + L+ + + + L++ L + ++ E
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 1230 KNHETVAAEYKKLCG-------ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1282
K AA KKL G + D + +K+ LQ K+ + L +++ +
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 1283 RLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
+ A + +++ + L+ +L + + + E L +++ + L R L+
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-SLSGRNALQ 1735
Query: 1343 QNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
+ K Q ++L E + E + +++
Sbjct: 1736 ---DEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Score = 134 bits (338), Expect = 6e-31
Identities = 154/767 (20%), Positives = 336/767 (43%), Gaps = 79/767 (10%)
Query: 136 QKKEEFIERI-QGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMA 194
QK + +E + + L+ +A + T +EN + V +++++E K +
Sbjct: 1206 QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLE 1265
Query: 195 LHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
++ L + + EL+ D +H L + S K + L+ ++A
Sbjct: 1266 AQVQELQSKCSDGERARAELN---DKVHKLQNEVESVTGMLNEAEGKAIK----LAKDVA 1318
Query: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
++++ ++ L+E+T Q L+ +L Q+E E LQ + +E++A
Sbjct: 1319 SLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ-------------LDEEMEA 1365
Query: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
+ + L ++S K++L D + + VE L+E + + L Q E A
Sbjct: 1366 KQNLERHISTLNIQLSDSKKKLQD---FASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE 434
DKL EK +L+ +L D+ ++ D R+ + L ++ + + + S E +
Sbjct: 1423 DKL---EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 435 QISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKIL 494
+ + E SL + E ++ +LE N+ L +E+L ++ D V N +
Sbjct: 1480 RAEAEAREKETKALSLARALEEALEAKE-ELERTNKMLKAEMEDLVSSKDDVGKN---VH 1535
Query: 495 KMEKENQRLSKKVEILENEIVQEKQSLQNCQN----LSKDLMKEKAQLEKTIETLRE-NS 549
++EK + L ++E ++ ++ + + LQ ++ L ++ K Q E+ ++ E N
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNE 1595
Query: 550 ERQIKILEQENEHLNQTVSSLRQRSQISA-----EARVKDIEKENKILHESIKETSSKLS 604
E++ ++ Q +E+ + +QR+ +A E +KD+E + + +E +L
Sbjct: 1596 EKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLR 1655
Query: 605 KIEFEKRQIKKELEHY-----------KEKGERAEELENELHHLEKENELLQKKITNLKI 653
K++ + + ++ELE KE ++A+ LE +L L+++ ++ +
Sbjct: 1656 KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADL 1715
Query: 654 TCEKI-----------EALEQENSELERENRKLKKTLDSFK-NLTFQLESLEKENSQLDE 701
E++ AL+ E LE +L++ L+ + N+ + + K Q ++
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT--------ER 753
+ EL + + QL+ +NKEL S+ +++ + K+ FK T +
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV---KSKFKSTIAALEAKIAQ 1832
Query: 754 LEVSYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMENQTLQKNLEELKISSKR 809
LE + E Q K+L+ +KK++ Q+E E + E + +K +K ++
Sbjct: 1833 LEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQ 1892
Query: 810 LEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENN 856
LE+ E+E++ + +L+++ + + N+ + ++ + L N
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGN 1939
Score = 131 bits (329), Expect = 7e-30
Identities = 180/799 (22%), Positives = 351/799 (43%), Gaps = 118/799 (14%)
Query: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK----EQLKKGLELL 744
L + ++ ++ + EL++ E + A ++ +L+ ++ +L EK EQL+ EL
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
+ + RL Q L+ ++ LE + QQL++E + + + L++ LEE +
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 805 ISSKRLEQLEK-----ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
+ ++L QLEK + K LE E ++ +L KE K L ++ T L E K
Sbjct: 971 AARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK-------------------RATI- 899
NL K +K + E VRLK+ EK +EL K +A I
Sbjct: 1030 KNL---TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 900 DIKTLVTLREDLVSEKL-----KTQQMNNDLEKLTHELE------KIGLNKERLLH---D 945
++K + +E+ + L + Q NN L+K+ ELE + L+ ER +
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSERAARNKAE 1145
Query: 946 EQSTD--DRYKLLESKLESTL-----KKSLEIK-EEKIAALEARLEESTNYNQQLRQELK 997
+Q D + + L+++LE TL ++ L K E+++ L+ L+E T ++ QE++
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 998 TVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
+K+ +A+++ ++ E+ ++ + E+E+ + EL + EVE
Sbjct: 1206 --QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
L+A+ Q L+++ E L ++ LQ + S+ + + KL + ++L+SQ
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 1117 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1176
Q+ Q L+Q+ + + N S KL L E + S + L
Sbjct: 1324 L-----QDTQELLQEETRQKLNVST-------------------KLRQLEEERNSLQDQL 1359
Query: 1177 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1236
+ A +NLE R + QL K +L+D ++ +E K E +
Sbjct: 1360 DEE----MEAKQNLE---RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 1237 AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE---AEFSKLKE 1293
+Y++ D+L T ++L +E + L D N + L++N + +Q + + AE +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 1294 QY-----------QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
+Y ++ + + L E + K LE N+ L +++ L+ +
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-- 1530
Query: 1343 QNMESKDLFHVE--QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK-- 1398
K++ +E +R ++ E++ Q E+LE D+ + + + R N LK
Sbjct: 1531 ----GKNVHELEKSKRALETQMEEMKTQLEELE----DELQATEDAKLRLEVNMQALKGQ 1582
Query: 1399 MRKLIKSKKDINRERQKSL 1417
+ ++++ + N E+++ L
Sbjct: 1583 FERDLQARDEQNEEKRRQL 1601
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 197 bits (500), Expect = 1e-49
Identities = 263/1120 (23%), Positives = 501/1120 (44%), Gaps = 163/1120 (14%)
Query: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
++ R +E++ K ++L K+ ++ E ELK L+Q++ L + + +++L A E
Sbjct: 853 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQEQLQAETEL 909
Query: 319 AVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVL-LETKTM------LEDQLEGT 370
+++ ++ K+ L +I +AR+EE ++ Q L E K M LE+QLE
Sbjct: 910 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 969
Query: 371 RARSDKLHELEKENLQLKAK--------LHDMEMERDMDRKKIEE--------LMEE--- 411
A KL +LEK + K K + D + +RK +EE L EE
Sbjct: 970 EAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 412 --NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG-----HEVNELTSSRLLK 464
N+T + +SM L + + E+ SR EL + +K G HE +++ +
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAE 1087
Query: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
L+M+ L K EEL+ + ++ ++ K+ + L + L+ ++ E+ +
Sbjct: 1088 LKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 525 QNLSKDLMKE----KAQLEKTIET------LRENSERQI----KILEQENEHLNQTVSSL 570
+ +DL +E K +LE T+++ LR E+++ K L++E V +
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 571 RQ-----------------RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
RQ R++ + + + +EKEN L ++ ++E +K+++
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 614 KKELEHYKEK---GERAE-ELENELHHLEKENELLQKKITNLKITCEKI-EALEQENSEL 668
+ +++ + K GERA EL +++H L+ E E + + + K+ + + +S+L
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1324
Query: 669 ERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEENLELRRNVE--------SLKCA 716
+ L++ N++ +L LE+E + QLDEE +E ++N+E L +
Sbjct: 1325 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE-MEAKQNLERHISTLNIQLSDS 1383
Query: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
K+ + LE K++ +K +E L + E +Y L+ RLQ+ L++
Sbjct: 1384 KKKLQDFASTVEALEEGKKRFQKEIENLTQQY---EEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 777 KKIQQLESELQDLEMENQTLQKNL-EELKISSK--------RLEQLEKENK--SLEQETS 825
+ + +LE + + + L EE ISSK E EKE K SL +
Sbjct: 1441 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
+ + K++LE+ NK L+ + E ++ ++ + LEK + L ++ +E +L+E
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM---EEMKTQLEE 1557
Query: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945
LE E +AT D K LR ++ + LK Q DL+ + E+ +R LH+
Sbjct: 1558 LEDE-----LQATEDAK----LRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHE 1607
Query: 946 -EQSTDDRYK------LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998
E +D K + KLE L K LE++ + +A++ R EE+ ++L+ ++K
Sbjct: 1608 YETELEDERKQRALAAAAKKKLEGDL-KDLELQAD--SAIKGR-EEAIKQLRKLQAQMKD 1663
Query: 999 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1058
++ E + +DE I + E++++ +L+++++ L ER
Sbjct: 1664 FQRELEDARASRDE---------IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 1059 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ-------------TQNAK 1105
EK+ L +L + N LQ + L+ + L+E+ Q TQ A+
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1774
Query: 1106 LQVENSTLNSQSTSLMNQNAQLLIQQSSLE-----NENESVIKEREDLKSLYDSLIKDHE 1160
Q+ N +ST+ N++A+ +++ + E +E E +K + KS +L
Sbjct: 1775 -QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK--FKSTIAALEAKIA 1831
Query: 1161 KLELLHERQASEYE----SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1216
+LE E++A E + SL K LK +E E + E Q K +++ L++
Sbjct: 1832 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1891
Query: 1217 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1256
L+ +E+ N N + E + N+ + + L
Sbjct: 1892 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1931
Score = 183 bits (464), Expect = 2e-45
Identities = 234/1094 (21%), Positives = 470/1094 (42%), Gaps = 141/1094 (12%)
Query: 364 EDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
ED+L+ T+ R K L ELE+++ QL + + ++ + + + E E + L A+
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA-AK 923
Query: 420 KQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
KQ ++E LH + LE+ + +A +K + ++ +L +LE E + K E
Sbjct: 924 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE----QLEEEEAARQKLQLE 979
Query: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
T ++ +IL M+ +N +LSK+ ++LE I +L + +K+L K K +
Sbjct: 980 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 539 EKTIETL----------RENSERQIKILEQENEHLNQTVSSLRQR--------------- 573
E I L R+ E+ + LE + ++ ++ L+ +
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1099
Query: 574 ------------SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621
+ +A +++++E L E + + +K E +KR + +ELE K
Sbjct: 1100 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1159
Query: 622 EKGERAEELENELHHLEKENELLQKK---ITNLKITCEKIEALEQENSELERENRKLK-K 677
ELE+ L + EL K+ +T LK +AL++E E + ++++ K
Sbjct: 1160 ------TELEDTLDSTATQQELRAKREQEVTVLK------KALDEETRSHEAQVQEMRQK 1207
Query: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
+ + LT QLE ++ + LD+ L + L + ++ L +E+E +K++L
Sbjct: 1208 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKL 1264
Query: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN--------------KKIQQLE 783
+ ++ L++ ER L+ + +LQ +E+ K + L
Sbjct: 1265 EAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1321
Query: 784 SELQDLE--MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
S+LQD + ++ +T QK L +S+K L QLE+E SL+ + + + K+ LE+ L
Sbjct: 1322 SQLQDTQELLQEETRQK----LNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376
Query: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRA 897
Q L++ + LE+ K KEI Y+E +LEK L +
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLE 957
+DLV + +Q+ ++LEK + ++LL +E++ +Y
Sbjct: 1437 -----------DDLVVDLDNQRQLVSNLEKKQRKF-------DQLLAEEKNISSKYADER 1478
Query: 958 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1017
+ E+ ++ KE K +L LEE+ ++L + K +K E L +D+ + +
Sbjct: 1479 DRAEAEARE----KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD--VGK 1532
Query: 1018 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL--------K 1069
+ + E + +E +L +++D L E L+ QALK Q +
Sbjct: 1533 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1592
Query: 1070 QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI 1129
Q E + LQ Q+ + + ++Q KL+ + L Q+ S + + +
Sbjct: 1593 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1652
Query: 1130 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1189
Q L+ + + +E ED ++ D + ++ E + ++ L + A K
Sbjct: 1653 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1712
Query: 1190 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE----QEKMLLENKNHETVAAEYKKLCGE 1245
++E +L + L + L+D ++ L+ +E++ E N E ++ +K +
Sbjct: 1713 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1772
Query: 1246 NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE----AEFSKLKEQYQQLDIT 1301
++L+ ++L E Q + + L +K +++L A SK K L+
Sbjct: 1773 AEQLS---NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1829
Query: 1302 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1361
+L Q E ++ K + + +++ ++LQ +E + + + + + +
Sbjct: 1830 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNAR 1885
Query: 1362 LNELRRQKEKLEEK 1375
+ +L+RQ E+ EE+
Sbjct: 1886 VKQLKRQLEEAEEE 1899
Score = 182 bits (461), Expect = 3e-45
Identities = 230/970 (23%), Positives = 433/970 (44%), Gaps = 102/970 (10%)
Query: 198 KRLIDER-DEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256
++L++ER + + + E E+ L L + S S K +SRQ L
Sbjct: 1008 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE------ 1061
Query: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
K K R+L + + EQ+ D + ++ +++++L + ++E A AR+ DE+
Sbjct: 1062 KLK-RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAALARL-DDEIAQKN 1114
Query: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-KTMLEDQLEGTRARSD 375
++ +LE +S +E L + + E+ K D LE KT LED L+ T + +
Sbjct: 1115 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1174
Query: 376 KLHELEKENLQLKAKL------HDMEME--RDMDRKKIEELMEENMTLEMAQ------KQ 421
+ E+E LK L H+ +++ R + +EEL E+ + A+ KQ
Sbjct: 1175 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1234
Query: 422 SMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
+++ E+ L EL + + + E +K L +V EL S+ E L V +L+
Sbjct: 1235 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-QSKCSDGERARAELNDKVHKLQ 1293
Query: 481 TTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
V+SV G + K +K+ K+ LS +++ + + +E + N + L +E+
Sbjct: 1294 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1353
Query: 537 QLEKTIET---LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
L+ ++ ++N ER I L + + + + E + K +KE + L
Sbjct: 1354 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK-KRFQKEIENLT 1412
Query: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE--LLQKKITNL 651
+ +E ++ K+E K ++++EL+ + +L + L +++ + L ++K +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
K E+ A E E E E + L + L+ E LE+ N L E +L V
Sbjct: 1473 KYADERDRA-EAEAREKETKALSLARALEEALEAK---EELERTNKMLKAEMEDL---VS 1525
Query: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE----RLEVSYQGLDIENQR 767
S + +L+ + LE++ E++K LE L+ + TE RLEV+ Q L + +R
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 768 -LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE--------QLEKENK 818
LQ E + +K +QL+ +L + E E + +K + K+LE Q + K
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1645
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKD---TTLEENNVKIGNLEKENKTLSKEIGI 875
E+ QL K + Q++ + L +D T +EN K +LE + L +++
Sbjct: 1646 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1705
Query: 876 YKESCVRLKELEKEN--KELV-----KRATIDIKT-----LVTLREDLVSEKLKTQQMNN 923
E + +LEKE +EL + A D K + L E+L E+ + M++
Sbjct: 1706 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1764
Query: 924 DLEKLTHELEKIG--LNKERLLH----------DEQSTDDRYKL--LESKLESTLKKSLE 969
+ K T + E++ L ER + Q+ + R KL +E ++S K ++
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824
Query: 970 IKEEKIAALEARLEESTNYNQQLRQELKTV-KKNYEALKQRQDEERMVQSSPPISGEDNK 1028
E KIA LE ++E+ Q + LK KK E L Q +DE +M + +
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE----------Q 1874
Query: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1088
++ ++++ + ++K +L E E + + A ++ L+ +L + N + ++ AL+ +
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Query: 1089 TVSLQEQNTT 1098
Q T+
Sbjct: 1935 LRGPPPQETS 1944
Score = 149 bits (376), Expect = 2e-35
Identities = 203/846 (23%), Positives = 361/846 (42%), Gaps = 98/846 (11%)
Query: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
EE++ + L+K E QK LK LEQ++S+L E L++ L + L
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELK-------ELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 688 QLES----LEKENSQLDEENLELRRNVES-------LKCASMKMAQLQLENKELESEKEQ 736
+ E L + +L+E E+ +E L+ KMAQ L+ +E E+E
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 971
Query: 737 LKKGLELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE--MEN 793
++ L+L K + + K ++LE +D +N +L K + ++I L + L + E +N
Sbjct: 972 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1031
Query: 794 QTLQKNLEELKISSK--RLEQLEKENKSLEQETSQLEKD------------------KKQ 833
T KN E IS RL++ EK + LE+ +LE D K Q
Sbjct: 1032 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091
Query: 834 LEKENKRLRQQ-AEIKDTTLEENNV--KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
L K+ + L+ A + D ++NN KI LE L +++ E R K EK+
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--SERAARNKA-EKQK 1148
Query: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
++L + +++ L T ED + Q++ E+ L+K L++E H+ Q +
Sbjct: 1149 RDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQE 1203
Query: 951 DRYKLLESKLEST--------LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKN 1002
R K ++ E T K +L+ ++ + A L Q +QE++ KK
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 1003 YEALKQR-----QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1057
EA Q D ER + ++ + +K + E + T L + + + I++ ++ A+L
Sbjct: 1264 LEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320
Query: 1058 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1117
++ Q + L++ Q N+ ++ L+ + SLQ+Q L+ STLN Q
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380
Query: 1118 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1177
+ + +LE + KE E+L Y+ ++KLE R E + L+
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1440
Query: 1178 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1237
+ NLE + R +++QLL ++ +++ E+++ E + ET A
Sbjct: 1441 VDLDNQRQLVSNLEKKQR----KFDQLLAEE---KNISSKYADERDRAEAEAREKETKAL 1493
Query: 1238 EYKKLCGE----NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1293
+ E + L T L E E L + ++ ++ + + LE + ++K
Sbjct: 1494 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1553
Query: 1294 QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV 1353
Q ++L+ ++ + K LE + L Q + LQ R EQN E +
Sbjct: 1554 QLEELE-------DELQATEDAKLRLEVNMQALKGQFER-DLQARD--EQNEEKRRQLQR 1603
Query: 1354 EQRQYIDKLNELRRQ-------KEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSK 1406
+ +Y +L + R+Q K+KLE + D D + R ++RKL
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQM 1661
Query: 1407 KDINRE 1412
KD RE
Sbjct: 1662 KDFQRE 1667
Score = 142 bits (357), Expect = 4e-33
Identities = 186/934 (19%), Positives = 405/934 (43%), Gaps = 82/934 (8%)
Query: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENE 561
R ++++ E+E+ + K+ Q +N K+L ++ +QL + L+E + + ++ + E
Sbjct: 856 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 915
Query: 562 HLNQTVSSLRQRSQI--SAEARVKDIEKENKILHESIKETSSKLSKIE---FEKRQIKKE 616
+ + ++ +I EAR+++ E + L K+ + ++ +E E+ +++
Sbjct: 916 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 975
Query: 617 LEHYKEKGE-RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
L+ K E + ++LE+E+ ++ +N L K+ K+ E+I L +E E + + L
Sbjct: 976 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNL 1032
Query: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE-------------SLKCASMKMAQ 722
K + +++ +LE K+ + +E +L+R +E + A +KM Q
Sbjct: 1033 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM-Q 1091
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL--DIENQRLQKTLENSNKKIQ 780
L + +EL++ +L + + KK LE L D++++R + + K+ +
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR--NKAEKQKR 1149
Query: 781 QLESELQDLEME-NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
L EL+ L+ E TL + ++ +KR +++ K+L++ET E Q+++ +
Sbjct: 1150 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQ 1206
Query: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE----------IGIYKESCV-RLKELEK 888
+ Q E LE+ NL+K +TL KE +G K+ + K+LE
Sbjct: 1207 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1266
Query: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948
+ +EL + + + L + K ++ N++E +T L + +L D S
Sbjct: 1267 QVQELQSKCSDGERARAELND-------KVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1319
Query: 949 ----TDDRYKLLESKLESTLKKSLEIK--EEKIAALEARLEESTNYNQQLRQELKTVK-K 1001
D +LL+ + L S +++ EE+ +L+ +L+E Q L + + T+ +
Sbjct: 1320 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1379
Query: 1002 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
++ K+ QD V++ + ++++E + T++ + ++E+ LQ E
Sbjct: 1380 LSDSKKKLQDFASTVEA---LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436
Query: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
L L +NL+ + + + ++ + + + E +++ SL
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496
Query: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYD-------SLIKDHEKLELLHERQASEYE 1174
+ L + LE N+ + E EDL S D L K LE E ++ E
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1556
Query: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED-----LEKMLKVEQEKMLLEN 1229
L + + A LEV + L+ ++ + L+ + + + L++ L + ++ E
Sbjct: 1557 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1616
Query: 1230 KNHETVAAEYKKLCG-------ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1282
K AA KKL G + D + +K+ LQ K+ + L +++ +
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676
Query: 1283 RLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
+ A + +++ + L+ +L + + + E L +++ + L R L+
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-SLSGRNALQ 1735
Query: 1343 QNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
+ K Q ++L E + E + +++
Sbjct: 1736 ---DEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1766
Score = 131 bits (329), Expect = 7e-30
Identities = 180/799 (22%), Positives = 351/799 (43%), Gaps = 118/799 (14%)
Query: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK----EQLKKGLELL 744
L + ++ ++ + EL++ E + A ++ +L+ ++ +L EK EQL+ EL
Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910
Query: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
+ + RL Q L+ ++ LE + QQL++E + + + L++ LEE +
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 805 ISSKRLEQLEK-----ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
+ ++L QLEK + K LE E ++ +L KE K L ++ T L E K
Sbjct: 971 AARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1029
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK-------------------RATI- 899
NL K +K + E VRLK+ EK +EL K +A I
Sbjct: 1030 KNL---TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 900 DIKTLVTLREDLVSEKL-----KTQQMNNDLEKLTHELE------KIGLNKERLLH---D 945
++K + +E+ + L + Q NN L+K+ ELE + L+ ER +
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSERAARNKAE 1145
Query: 946 EQSTD--DRYKLLESKLESTL-----KKSLEIK-EEKIAALEARLEESTNYNQQLRQELK 997
+Q D + + L+++LE TL ++ L K E+++ L+ L+E T ++ QE++
Sbjct: 1146 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1205
Query: 998 TVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
+K+ +A+++ ++ E+ ++ + E+E+ + EL + EVE
Sbjct: 1206 --QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1263
Query: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
L+A+ Q L+++ E L ++ LQ + S+ + + KL + ++L+SQ
Sbjct: 1264 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1323
Query: 1117 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1176
Q+ Q L+Q+ + + N S KL L E + S + L
Sbjct: 1324 L-----QDTQELLQEETRQKLNVST-------------------KLRQLEEERNSLQDQL 1359
Query: 1177 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1236
+ A +NLE R + QL K +L+D ++ +E K E +
Sbjct: 1360 DEE----MEAKQNLE---RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1412
Query: 1237 AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE---AEFSKLKE 1293
+Y++ D+L T ++L +E + L D N + L++N + +Q + + AE +
Sbjct: 1413 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1472
Query: 1294 QY-----------QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
+Y ++ + + L E + K LE N+ L +++ L+ +
Sbjct: 1473 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-- 1530
Query: 1343 QNMESKDLFHVE--QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK-- 1398
K++ +E +R ++ E++ Q E+LE D+ + + + R N LK
Sbjct: 1531 ----GKNVHELEKSKRALETQMEEMKTQLEELE----DELQATEDAKLRLEVNMQALKGQ 1582
Query: 1399 MRKLIKSKKDINRERQKSL 1417
+ ++++ + N E+++ L
Sbjct: 1583 FERDLQARDEQNEEKRRQL 1601
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 197 bits (500), Expect = 1e-49
Identities = 263/1120 (23%), Positives = 501/1120 (44%), Gaps = 163/1120 (14%)
Query: 259 KIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREK 318
++ R +E++ K ++L K+ ++ E ELK L+Q++ L + + +++L A E
Sbjct: 846 QVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE---KNLLQEQLQAETEL 902
Query: 319 AVRVDKLESEVSRYKERLHDI-EFYKARVEELKEDNQVL-LETKTM------LEDQLEGT 370
+++ ++ K+ L +I +AR+EE ++ Q L E K M LE+QLE
Sbjct: 903 YAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEE 962
Query: 371 RARSDKLHELEKENLQLKAK--------LHDMEMERDMDRKKIEE--------LMEE--- 411
A KL +LEK + K K + D + +RK +EE L EE
Sbjct: 963 EAARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 412 --NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG-----HEVNELTSSRLLK 464
N+T + +SM L + + E+ SR EL + +K G HE +++ +
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSR-QELEKLKRKLEGDASDFHEQIADLQAQIAE 1080
Query: 465 LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNC 524
L+M+ L K EEL+ + ++ ++ K+ + L + L+ ++ E+ +
Sbjct: 1081 LKMQ---LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 525 QNLSKDLMKE----KAQLEKTIET------LRENSERQI----KILEQENEHLNQTVSSL 570
+ +DL +E K +LE T+++ LR E+++ K L++E V +
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 571 RQ-----------------RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
RQ R++ + + + +EKEN L ++ ++E +K+++
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 614 KKELEHYKEK---GERAE-ELENELHHLEKENELLQKKITNLKITCEKI-EALEQENSEL 668
+ +++ + K GERA EL +++H L+ E E + + + K+ + + +S+L
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQL 1317
Query: 669 ERENRKLKKTLDSFKNLTFQLESLEKENS----QLDEENLELRRNVE--------SLKCA 716
+ L++ N++ +L LE+E + QLDEE +E ++N+E L +
Sbjct: 1318 QDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEE-MEAKQNLERHISTLNIQLSDS 1376
Query: 717 SMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
K+ + LE K++ +K +E L + E +Y L+ RLQ+ L++
Sbjct: 1377 KKKLQDFASTVEALEEGKKRFQKEIENLTQQY---EEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 777 KKIQQLESELQDLEMENQTLQKNL-EELKISSK--------RLEQLEKENK--SLEQETS 825
+ + +LE + + + L EE ISSK E EKE K SL +
Sbjct: 1434 VDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE 885
+ + K++LE+ NK L+ + E ++ ++ + LEK + L ++ +E +L+E
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQM---EEMKTQLEE 1550
Query: 886 LEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD 945
LE E +AT D K LR ++ + LK Q DL+ + E+ +R LH+
Sbjct: 1551 LEDE-----LQATEDAK----LRLEVNMQALK-GQFERDLQARDEQNEEKRRQLQRQLHE 1600
Query: 946 -EQSTDDRYK------LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998
E +D K + KLE L K LE++ + +A++ R EE+ ++L+ ++K
Sbjct: 1601 YETELEDERKQRALAAAAKKKLEGDL-KDLELQAD--SAIKGR-EEAIKQLRKLQAQMKD 1656
Query: 999 VKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQ 1058
++ E + +DE I + E++++ +L+++++ L ER
Sbjct: 1657 FQRELEDARASRDE---------IFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 1059 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQ-------------TQNAK 1105
EK+ L +L + N LQ + L+ + L+E+ Q TQ A+
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAE 1767
Query: 1106 LQVENSTLNSQSTSLMNQNAQLLIQQSSLE-----NENESVIKEREDLKSLYDSLIKDHE 1160
Q+ N +ST+ N++A+ +++ + E +E E +K + KS +L
Sbjct: 1768 -QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSK--FKSTIAALEAKIA 1824
Query: 1161 KLELLHERQASEYE----SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEK 1216
+LE E++A E + SL K LK +E E + E Q K +++ L++
Sbjct: 1825 QLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKR 1884
Query: 1217 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1256
L+ +E+ N N + E + N+ + + L
Sbjct: 1885 QLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNAL 1924
Score = 183 bits (464), Expect = 2e-45
Identities = 234/1094 (21%), Positives = 470/1094 (42%), Gaps = 141/1094 (12%)
Query: 364 EDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQ 419
ED+L+ T+ R K L ELE+++ QL + + ++ + + + E E + L A+
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLA-AK 916
Query: 420 KQSMDESLH-LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEE 478
KQ ++E LH + LE+ + +A +K + ++ +L +LE E + K E
Sbjct: 917 KQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE----QLEEEEAARQKLQLE 972
Query: 479 LRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQL 538
T ++ +IL M+ +N +LSK+ ++LE I +L + +K+L K K +
Sbjct: 973 KVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 539 EKTIETL----------RENSERQIKILEQENEHLNQTVSSLRQR--------------- 573
E I L R+ E+ + LE + ++ ++ L+ +
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEEL 1092
Query: 574 ------------SQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK 621
+ +A +++++E L E + + +K E +KR + +ELE K
Sbjct: 1093 QAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALK 1152
Query: 622 EKGERAEELENELHHLEKENELLQKK---ITNLKITCEKIEALEQENSELERENRKLK-K 677
ELE+ L + EL K+ +T LK +AL++E E + ++++ K
Sbjct: 1153 ------TELEDTLDSTATQQELRAKREQEVTVLK------KALDEETRSHEAQVQEMRQK 1200
Query: 678 TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQL 737
+ + LT QLE ++ + LD+ L + L + ++ L +E+E +K++L
Sbjct: 1201 HAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL---AGELRVLGQAKQEVEHKKKKL 1257
Query: 738 KKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN--------------KKIQQLE 783
+ ++ L++ ER L+ + +LQ +E+ K + L
Sbjct: 1258 EAQVQELQSKCSDGERARAE---LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLS 1314
Query: 784 SELQDLE--MENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL 841
S+LQD + ++ +T QK L +S+K L QLE+E SL+ + + + K+ LE+ L
Sbjct: 1315 SQLQDTQELLQEETRQK----LNVSTK-LRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369
Query: 842 RQQAEIKDTTLEENNVKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRA 897
Q L++ + LE+ K KEI Y+E +LEK L +
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLE 957
+DLV + +Q+ ++LEK + ++LL +E++ +Y
Sbjct: 1430 -----------DDLVVDLDNQRQLVSNLEKKQRKF-------DQLLAEEKNISSKYADER 1471
Query: 958 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1017
+ E+ ++ KE K +L LEE+ ++L + K +K E L +D+ + +
Sbjct: 1472 DRAEAEARE----KETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDD--VGK 1525
Query: 1018 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL--------K 1069
+ + E + +E +L +++D L E L+ QALK Q +
Sbjct: 1526 NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDE 1585
Query: 1070 QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI 1129
Q E + LQ Q+ + + ++Q KL+ + L Q+ S + + +
Sbjct: 1586 QNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIK 1645
Query: 1130 QQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1189
Q L+ + + +E ED ++ D + ++ E + ++ L + A K
Sbjct: 1646 QLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQ 1705
Query: 1190 LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE----QEKMLLENKNHETVAAEYKKLCGE 1245
++E +L + L + L+D ++ L+ +E++ E N E ++ +K +
Sbjct: 1706 ADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQ 1765
Query: 1246 NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE----AEFSKLKEQYQQLDIT 1301
++L+ ++L E Q + + L +K +++L A SK K L+
Sbjct: 1766 AEQLS---NELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAK 1822
Query: 1302 STKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDK 1361
+L Q E ++ K + + +++ ++LQ +E + + + + + +
Sbjct: 1823 IAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQ----VEDERKMAEQYKEQAEKGNAR 1878
Query: 1362 LNELRRQKEKLEEK 1375
+ +L+RQ E+ EE+
Sbjct: 1879 VKQLKRQLEEAEEE 1892
Score = 182 bits (461), Expect = 3e-45
Identities = 230/970 (23%), Positives = 433/970 (44%), Gaps = 102/970 (10%)
Query: 198 KRLIDER-DEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADA 256
++L++ER + + + E E+ L L + S S K +SRQ L
Sbjct: 1001 RKLLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELE------ 1054
Query: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
K K R+L + + EQ+ D + ++ +++++L + ++E A AR+ DE+
Sbjct: 1055 KLK-RKLEGDASDFHEQIADLQAQIAELKMQLAKKEEE-----LQAALARL-DDEIAQKN 1107
Query: 317 EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-KTMLEDQLEGTRARSD 375
++ +LE +S +E L + + E+ K D LE KT LED L+ T + +
Sbjct: 1108 NALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQE 1167
Query: 376 KLHELEKENLQLKAKL------HDMEME--RDMDRKKIEELMEENMTLEMAQ------KQ 421
+ E+E LK L H+ +++ R + +EEL E+ + A+ KQ
Sbjct: 1168 LRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQ 1227
Query: 422 SMD-ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELR 480
+++ E+ L EL + + + E +K L +V EL S+ E L V +L+
Sbjct: 1228 TLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL-QSKCSDGERARAELNDKVHKLQ 1286
Query: 481 TTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
V+SV G + K +K+ K+ LS +++ + + +E + N + L +E+
Sbjct: 1287 NEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERN 1346
Query: 537 QLEKTIET---LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILH 593
L+ ++ ++N ER I L + + + + E + K +KE + L
Sbjct: 1347 SLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGK-KRFQKEIENLT 1405
Query: 594 ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENE--LLQKKITNL 651
+ +E ++ K+E K ++++EL+ + +L + L +++ + L ++K +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE 711
K E+ A E E E E + L + L+ E LE+ N L E +L V
Sbjct: 1466 KYADERDRA-EAEAREKETKALSLARALEEALEAK---EELERTNKMLKAEMEDL---VS 1518
Query: 712 SLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE----RLEVSYQGLDIENQR 767
S + +L+ + LE++ E++K LE L+ + TE RLEV+ Q L + +R
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 768 -LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLE--------QLEKENK 818
LQ E + +K +QL+ +L + E E + +K + K+LE Q + K
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK 1638
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKD---TTLEENNVKIGNLEKENKTLSKEIGI 875
E+ QL K + Q++ + L +D T +EN K +LE + L +++
Sbjct: 1639 GREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAA 1698
Query: 876 YKESCVRLKELEKEN--KELV-----KRATIDIKT-----LVTLREDLVSEKLKTQQMNN 923
E + +LEKE +EL + A D K + L E+L E+ + M++
Sbjct: 1699 -AERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSD 1757
Query: 924 DLEKLTHELEKIG--LNKERLLH----------DEQSTDDRYKL--LESKLESTLKKSLE 969
+ K T + E++ L ER + Q+ + R KL +E ++S K ++
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817
Query: 970 IKEEKIAALEARLEESTNYNQQLRQELKTV-KKNYEALKQRQDEERMVQSSPPISGEDNK 1028
E KIA LE ++E+ Q + LK KK E L Q +DE +M + +
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAE----------Q 1867
Query: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1088
++ ++++ + ++K +L E E + + A ++ L+ +L + N + ++ AL+ +
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1927
Query: 1089 TVSLQEQNTT 1098
Q T+
Sbjct: 1928 LRGPPPQETS 1937
Score = 149 bits (376), Expect = 2e-35
Identities = 203/846 (23%), Positives = 361/846 (42%), Gaps = 98/846 (11%)
Query: 628 EELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTF 687
EE++ + L+K E QK LK LEQ++S+L E L++ L + L
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELK-------ELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 688 QLES----LEKENSQLDEENLELRRNVES-------LKCASMKMAQLQLENKELESEKEQ 736
+ E L + +L+E E+ +E L+ KMAQ L+ +E E+E
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEA 964
Query: 737 LKKGLELLKASFK-KTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLE--MEN 793
++ L+L K + + K ++LE +D +N +L K + ++I L + L + E +N
Sbjct: 965 ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKN 1024
Query: 794 QTLQKNLEELKISSK--RLEQLEKENKSLEQETSQLEKD------------------KKQ 833
T KN E IS RL++ EK + LE+ +LE D K Q
Sbjct: 1025 LTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084
Query: 834 LEKENKRLRQQ-AEIKDTTLEENNV--KIGNLEKENKTLSKEIGIYKESCVRLKELEKEN 890
L K+ + L+ A + D ++NN KI LE L +++ E R K EK+
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLD--SERAARNKA-EKQK 1141
Query: 891 KELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTD 950
++L + +++ L T ED + Q++ E+ L+K L++E H+ Q +
Sbjct: 1142 RDLGE----ELEALKTELEDTLDSTATQQELRAKREQEVTVLKK-ALDEETRSHEAQVQE 1196
Query: 951 DRYKLLESKLEST--------LKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKN 1002
R K ++ E T K +L+ ++ + A L Q +QE++ KK
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 1003 YEALKQR-----QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATL 1057
EA Q D ER + ++ + +K + E + T L + + + I++ ++ A+L
Sbjct: 1257 LEAQVQELQSKCSDGER---ARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313
Query: 1058 QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQS 1117
++ Q + L++ Q N+ ++ L+ + SLQ+Q L+ STLN Q
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373
Query: 1118 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1177
+ + +LE + KE E+L Y+ ++KLE R E + L+
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLV 1433
Query: 1178 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA 1237
+ NLE + R +++QLL ++ +++ E+++ E + ET A
Sbjct: 1434 VDLDNQRQLVSNLEKKQR----KFDQLLAEE---KNISSKYADERDRAEAEAREKETKAL 1486
Query: 1238 EYKKLCGE----NDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKE 1293
+ E + L T L E E L + ++ ++ + + LE + ++K
Sbjct: 1487 SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKT 1546
Query: 1294 QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHV 1353
Q ++L+ ++ + K LE + L Q + LQ R EQN E +
Sbjct: 1547 QLEELE-------DELQATEDAKLRLEVNMQALKGQFER-DLQARD--EQNEEKRRQLQR 1596
Query: 1354 EQRQYIDKLNELRRQ-------KEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSK 1406
+ +Y +L + R+Q K+KLE + D D + R ++RKL
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREE--AIKQLRKLQAQM 1654
Query: 1407 KDINRE 1412
KD RE
Sbjct: 1655 KDFQRE 1660
Score = 142 bits (357), Expect = 4e-33
Identities = 186/934 (19%), Positives = 405/934 (43%), Gaps = 82/934 (8%)
Query: 502 RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENE 561
R ++++ E+E+ + K+ Q +N K+L ++ +QL + L+E + + ++ + E
Sbjct: 849 RQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEE 908
Query: 562 HLNQTVSSLRQRSQI--SAEARVKDIEKENKILHESIKETSSKLSKIE---FEKRQIKKE 616
+ + ++ +I EAR+++ E + L K+ + ++ +E E+ +++
Sbjct: 909 MRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQK 968
Query: 617 LEHYKEKGE-RAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
L+ K E + ++LE+E+ ++ +N L K+ K+ E+I L +E E + + L
Sbjct: 969 LQLEKVTAEAKIKKLEDEILVMDDQNNKLSKE---RKLLEERISDLTTNLAEEEEKAKNL 1025
Query: 676 KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVE-------------SLKCASMKMAQ 722
K + +++ +LE K+ + +E +L+R +E + A +KM Q
Sbjct: 1026 TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM-Q 1084
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL--DIENQRLQKTLENSNKKIQ 780
L + +EL++ +L + + KK LE L D++++R + + K+ +
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR--NKAEKQKR 1142
Query: 781 QLESELQDLEME-NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENK 839
L EL+ L+ E TL + ++ +KR +++ K+L++ET E Q+++ +
Sbjct: 1143 DLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHE---AQVQEMRQ 1199
Query: 840 RLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE----------IGIYKESCV-RLKELEK 888
+ Q E LE+ NL+K +TL KE +G K+ + K+LE
Sbjct: 1200 KHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEA 1259
Query: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948
+ +EL + + + L + K ++ N++E +T L + +L D S
Sbjct: 1260 QVQELQSKCSDGERARAELND-------KVHKLQNEVESVTGMLNEAEGKAIKLAKDVAS 1312
Query: 949 ----TDDRYKLLESKLESTLKKSLEIK--EEKIAALEARLEESTNYNQQLRQELKTVK-K 1001
D +LL+ + L S +++ EE+ +L+ +L+E Q L + + T+ +
Sbjct: 1313 LSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQ 1372
Query: 1002 NYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
++ K+ QD V++ + ++++E + T++ + ++E+ LQ E
Sbjct: 1373 LSDSKKKLQDFASTVEA---LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429
Query: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
L L +NL+ + + + ++ + + + E +++ SL
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489
Query: 1122 NQNAQLLIQQSSLENENESVIKEREDLKSLYD-------SLIKDHEKLELLHERQASEYE 1174
+ L + LE N+ + E EDL S D L K LE E ++ E
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLE 1549
Query: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED-----LEKMLKVEQEKMLLEN 1229
L + + A LEV + L+ ++ + L+ + + + L++ L + ++ E
Sbjct: 1550 ELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDER 1609
Query: 1230 KNHETVAAEYKKLCG-------ENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQT 1282
K AA KKL G + D + +K+ LQ K+ + L +++ +
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669
Query: 1283 RLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
+ A + +++ + L+ +L + + + E L +++ + L R L+
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELAS-SLSGRNALQ 1728
Query: 1343 QNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
+ K Q ++L E + E + +++
Sbjct: 1729 ---DEKRRLEARIAQLEEELEEEQGNMEAMSDRV 1759
Score = 131 bits (329), Expect = 7e-30
Identities = 180/799 (22%), Positives = 351/799 (43%), Gaps = 118/799 (14%)
Query: 689 LESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEK----EQLKKGLELL 744
L + ++ ++ + EL++ E + A ++ +L+ ++ +L EK EQL+ EL
Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903
Query: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK 804
+ + RL Q L+ ++ LE + QQL++E + + + L++ LEE +
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 805 ISSKRLEQLEK-----ENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKI 859
+ ++L QLEK + K LE E ++ +L KE K L ++ T L E K
Sbjct: 964 AARQKL-QLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKA 1022
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVK-------------------RATI- 899
NL K +K + E VRLK+ EK +EL K +A I
Sbjct: 1023 KNL---TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 900 DIKTLVTLREDLVSEKL-----KTQQMNNDLEKLTHELE------KIGLNKERLLH---D 945
++K + +E+ + L + Q NN L+K+ ELE + L+ ER +
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKI-RELEGHISDLQEDLDSERAARNKAE 1138
Query: 946 EQSTD--DRYKLLESKLESTL-----KKSLEIK-EEKIAALEARLEESTNYNQQLRQELK 997
+Q D + + L+++LE TL ++ L K E+++ L+ L+E T ++ QE++
Sbjct: 1139 KQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMR 1198
Query: 998 TVKKNYEALKQRQDE-ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
+K+ +A+++ ++ E+ ++ + E+E+ + EL + EVE
Sbjct: 1199 --QKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKK 1256
Query: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
L+A+ Q L+++ E L ++ LQ + S+ + + KL + ++L+SQ
Sbjct: 1257 LEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQ 1316
Query: 1117 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1176
Q+ Q L+Q+ + + N S KL L E + S + L
Sbjct: 1317 L-----QDTQELLQEETRQKLNVST-------------------KLRQLEEERNSLQDQL 1352
Query: 1177 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVA 1236
+ A +NLE R + QL K +L+D ++ +E K E +
Sbjct: 1353 DEE----MEAKQNLE---RHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLT 1405
Query: 1237 AEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLE---AEFSKLKE 1293
+Y++ D+L T ++L +E + L D N + L++N + +Q + + AE +
Sbjct: 1406 QQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISS 1465
Query: 1294 QY-----------QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLE 1342
+Y ++ + + L E + K LE N+ L +++ L+ +
Sbjct: 1466 KYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDV-- 1523
Query: 1343 QNMESKDLFHVE--QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK-- 1398
K++ +E +R ++ E++ Q E+LE D+ + + + R N LK
Sbjct: 1524 ----GKNVHELEKSKRALETQMEEMKTQLEELE----DELQATEDAKLRLEVNMQALKGQ 1575
Query: 1399 MRKLIKSKKDINRERQKSL 1417
+ ++++ + N E+++ L
Sbjct: 1576 FERDLQARDEQNEEKRRQL 1594
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 194 bits (493), Expect = 7e-49
Identities = 298/1343 (22%), Positives = 578/1343 (43%), Gaps = 191/1343 (14%)
Query: 58 KLESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQG 117
KL+S+ ++ HN V+ +K +Q+ + +L F
Sbjct: 403 KLKSELAGLNKQFCYTVEQHNRE--VQSLKEQHQKEISEL------------NETFLSDS 448
Query: 118 TEEVKKLLLLLLGCAVQC----QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDL 173
+E L+ + G QC Q+K+E I L++++ + +Q
Sbjct: 449 EKEKLTLMFEIQGLKEQCENLQQEKQEAI-----LNYESLREIMEILQTELGESAGKISQ 503
Query: 174 QWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGL----HFLPHASS 229
++ + D+ L + L+ E+D ET+ L E + L +P +
Sbjct: 504 EFESMKQQQASDVHELQQK----LRTAFTEKDALLETVNRLQGENEKLLSQQELVPELEN 559
Query: 230 SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELK 289
+ ++ G+ Q ++ L + + KI L +E ++ +L + +E++ + +
Sbjct: 560 TIKNLQEKNGVYLLSLSQRDTM-LKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCE 618
Query: 290 RLQQENMNLLSDARSARMYRDELD------------ALREKAVRVDKLESEVSRYKERLH 337
R ++ + L Y EL+ L+EK KLE + + K
Sbjct: 619 REERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSE 678
Query: 338 DIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEME 397
D E A V+ L E+N L K L LE + +KE++ LK + +E
Sbjct: 679 DKEVLSAEVKSLYEENNKLSSEKKQLSRDLE--------VFLSQKEDVILKEHITQLE-- 728
Query: 398 RDMDRKKIEELMEE----NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHE 453
KK++ ++EE N LE Q Q + L L+++ SE+SE ++
Sbjct: 729 -----KKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMG--SEVSEDSEEKDVVN 781
Query: 454 VNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENE 513
V + L K+ E +L +E K+L++EKE ++ L+ E
Sbjct: 782 VLQAVGESLAKINEEKCNLAFQRDE-------------KVLELEKE-------IKCLQEE 821
Query: 514 IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER-QIKILEQENEHLNQTVSSLRQ 572
V + + L++ L +D +EK L K +E ++ E Q +LE +N + +
Sbjct: 822 SVVQCEELKS---LLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNAN---------E 869
Query: 573 RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN 632
++++ + + +E+ ++ +S E ++ K ++ + K L KE +R EL
Sbjct: 870 KTRLENQNLLIQVEEVSQTCSKS--EIHNEKEKCFIKEHENLKPLLEQKELRDRRAELIL 927
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK-------KTLDSFKNL 685
L K + ++++K EKIE LE+E E E + K+K K LDS +
Sbjct: 928 LKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKE 987
Query: 686 TF----QLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
T +LESL E QL +L + ES K + + + ++++L+ EKE+
Sbjct: 988 TQTVKEELESLRSEKDQLSASMRDLIQGAESYKNL---LLEYEKQSEQLDVEKERANNFE 1044
Query: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
++ ++ + + ++ +N+ L +E + LE ++ +++ + K LE
Sbjct: 1045 HRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELE 1104
Query: 802 ELKISSK-RLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ-QAEIKDTTLEENNVKI 859
K+ + ++++ LE+ QL+K+KKQL+K + L + + + TTL N++I
Sbjct: 1105 AEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLM--NMEI 1162
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQ 919
+ E+ K L++++ ++++LE+E K I + TL+E++ S + Q
Sbjct: 1163 ADYERLMKELNQKLTNKNN---KIEDLEQEIK-------IQKQKQETLQEEITSLQSSVQ 1212
Query: 920 QMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALE 979
Q K+ L K K+ L +Q+ D L +++LK LE ++++ +
Sbjct: 1213 QYEEKNTKIKQLLVK---TKKELADSKQAETDHLIL-----QASLKGELEASQQQVEVYK 1264
Query: 980 ARLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTR 1038
+L E T+ ++ + LKT + ++ L Q +Q + K E+ + +
Sbjct: 1265 IQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAA----KAEQATVTSEF 1320
Query: 1039 ELLKVK-DRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNT 1097
E KV+ +++ ++N + QAE + K + + LE + + + + LQ+
Sbjct: 1321 ESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLE----------MLIDQLKIKLQDSQN 1370
Query: 1098 TLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIK 1157
LQ ++LQ TL S+ +L+ ++ ++L E+V KE E L+ S+
Sbjct: 1371 NLQINVSELQ----TLQSEHDTLLERHNKML---------QETVSKEAE-LREKLCSIQS 1416
Query: 1158 DHEKLELLHERQASEYESLISKHGTLKSAHKN----LEVEHRD-LEDRYNQLLKQKGQLE 1212
++ ++ H + S+ L S++ L+++ ++ L+ EHR +E QL K + QL
Sbjct: 1417 ENMMMKSEHTQTVSQ---LTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLF 1473
Query: 1213 DLEK-------MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQT 1265
L+ + + K L E +N + + + E T + T
Sbjct: 1474 QLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDT--ESVSSAST 1531
Query: 1266 DHKNLKSLLNN--SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEEN 1323
++L+ LLN+ +KLE AEF+K +E Q+L T+ ++ L+ L E N
Sbjct: 1532 YTQSLEQLLNSPETKLEPPLWHAEFTK-EELVQKLSSTTKSADH----LNGLLRETEATN 1586
Query: 1324 RHLLDQIQTLMLQNRTLLEQNME 1346
L++QI+ L + R LE+N E
Sbjct: 1587 AILMEQIKLLKSEIRR-LERNQE 1608
Score = 178 bits (452), Expect = 4e-44
Identities = 270/1222 (22%), Positives = 541/1222 (44%), Gaps = 196/1222 (16%)
Query: 196 HLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGS-PGMKRTESRQHLSVELA 254
H + + +++H + I EL+E FL + + G+K E ++L E
Sbjct: 422 HNREVQSLKEQHQKEISELNET-----FLSDSEKEKLTLMFEIQGLK--EQCENLQQEKQ 474
Query: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
+A LR+ +E +L + ++ Q +K+ Q +++ L + R E DA
Sbjct: 475 EAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQ--QKLRTAFTEKDA 532
Query: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL----ETKTMLEDQLEGT 370
L E R+ ++ +E + ++E ++ L+E N V L + TML++ LEG
Sbjct: 533 LLETVNRLQGENEKLLSQQELVPELE---NTIKNLQEKNGVYLLSLSQRDTMLKE-LEG- 587
Query: 371 RARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLG 430
K++ L +E KL + E D KK E EE + LE+ +K +++++
Sbjct: 588 -----KINSLTEEKDDFINKLKNSHEEMDNFHKKCER--EERLILELGKK--VEQTIQYN 638
Query: 431 WELEQISRTSELSEAPQKSLGHEVNELTSS---RLLKLEMENQSLTKTVEELRTTVDSVE 487
ELEQ +VNELT L + + +Q L K + +++ + E
Sbjct: 639 SELEQ-----------------KVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKE 681
Query: 488 GNASKILKMEKENQRLSKKVEILENEI---VQEKQSLQNCQNLSKDLMKEK-AQLEKTIE 543
++++ + +EN +LS + + L ++ + +K+ + ++KE QLEK ++
Sbjct: 682 VLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDV---------ILKEHITQLEKKLQ 732
Query: 544 TLRENSERQIKILEQENEHL----NQTVSSLRQR-SQISAEARVKDIEKENKILHESIKE 598
+ E + K+LE E Q L++ S++S ++ KD+ + + ES+ +
Sbjct: 733 LMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAK 792
Query: 599 TSSKLSKIEFEKRQIKKELEH-----YKEKGERAEELENELHHLEKENELLQKKITNLKI 653
+ + + F++ + ELE +E + EEL++ L E+E LL+K++ +I
Sbjct: 793 INEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELE--EI 850
Query: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
EK EAL+ + E++ N K + L++ +NL Q+E + + S+ + N E
Sbjct: 851 QSEK-EALQSDLLEMKNANEKTR--LEN-QNLLIQVEEVSQTCSKSEIHN-------EKE 899
Query: 714 KCASMKMAQLQ--LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKT 771
KC + L+ LE KEL + +L LLK S K+ ++N L
Sbjct: 900 KCFIKEHENLKPLLEQKELRDRRAELI----LLKDSLAKSP---------SVKNDPLSS- 945
Query: 772 LENSNKKIQQLESELQDLEMENQTLQKNLEELKI----SSKRLEQLEKENKSLEQETSQL 827
+++LE ++++LE E + ++ + ++K+ + K L+ KE +++++E L
Sbjct: 946 -------VKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESL 998
Query: 828 EKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELE 887
+K QL + L Q AE NL E + S+++ + KE +
Sbjct: 999 RSEKDQLSASMRDLIQGAE-----------SYKNLLLEYEKQSEQLDVEKERANNFEHRI 1047
Query: 888 KENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQ 947
++ ++ +T+ +T+ + EDL++ +++T Q N L E++ + + + + + D++
Sbjct: 1048 EDLTRQLRNSTLQCETINSDNEDLLA-RIETLQSNAKLL----EVQILEVQRAKAMVDKE 1102
Query: 948 STDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALK 1007
++ + E K++ E++E L+ +L++ Q+ QEL+ VKK+
Sbjct: 1103 LEAEKLQK-EQKIKEHATTVNELEE-----LQVQLQKEKKQLQKTMQELELVKKD----- 1151
Query: 1008 QRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQ 1067
Q + ++ E +ER +E ++L +++ ++E Q +K Q
Sbjct: 1152 --------AQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLE----------QEIKIQ 1193
Query: 1068 LKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQL 1127
++ ET LQ +I +LQ +E+NT ++ K + E + T + A L
Sbjct: 1194 KQKQET----LQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASL 1249
Query: 1128 LIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL---HERQASEYESLIS------ 1178
+ LE + V + L + K HE L+ H+R S Y+ ++
Sbjct: 1250 ---KGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEEC 1306
Query: 1179 -----KHGTLKSAHKNLEVE-HRDLEDRYNQLLKQ------KGQLEDLEKMLKVEQEKML 1226
+ T+ S ++ +V H L+ + N+ + Q K + E LE ++ + K+
Sbjct: 1307 RAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQ 1366
Query: 1227 LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEA 1286
N + +E + L E+D L ++++L+ET + + L+ L + + E +++
Sbjct: 1367 DSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAE---LREKLCSIQSENMMMKS 1423
Query: 1287 EFSKLKEQY-QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQI-QTLMLQNRTLLEQN 1344
E ++ Q Q ++ +Q +L+EE+R ++ + Q L L +
Sbjct: 1424 EHTQTVSQLTSQNEVLRNSFRDQVR-------HLQEEHRKTVETLQQQLSKMEAQLFQLK 1476
Query: 1345 MESKDLFHVEQRQYIDKLNELR 1366
E V +Q + L E R
Sbjct: 1477 NEPTTRSPVSSQQSLKNLRERR 1498
Score = 169 bits (429), Expect = 2e-41
Identities = 259/1213 (21%), Positives = 526/1213 (43%), Gaps = 185/1213 (15%)
Query: 137 KKEEFIERIQGLDFDTKAAVAAH--IQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMA 194
+K+ +E + L + + ++ + E+ + +N+ + + + +SQ D +LK +
Sbjct: 529 EKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDT--MLKELE 586
Query: 195 LHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
+ L +E+D+ + EE D H K+ E + L +EL
Sbjct: 587 GKINSLTEEKDDFINKLKNSHEEMDNFH------------------KKCEREERLILELG 628
Query: 255 DAKAKIRRLRQELEEKTEQLL----DCKQELEQMEIELKRLQQENMNLLSDARSARMYRD 310
+ + ELE+K +L + +E +Q + +L++L + M +LS+ + +
Sbjct: 629 KKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQ-MKVLSEDKE--VLSA 685
Query: 311 ELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGT 370
E+ +L E+ ++ + ++SR D+E + ++ E++ +L E T LE +L+
Sbjct: 686 EVKSLYEENNKLSSEKKQLSR------DLEVFLSQKEDV-----ILKEHITQLEKKLQLM 734
Query: 371 RARSDKLHEL-EKENLQ---LKAKLHDM------EMERDMDRKKI--------------- 405
D L++L E E +Q +K +L+ E+ D + K +
Sbjct: 735 VEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKIN 794
Query: 406 -----------EELMEENMTLEMAQKQSMDE-----SLHLGWELEQISRTSELSE--APQ 447
E+++E ++ Q++S+ + SL +E E++ EL E + +
Sbjct: 795 EEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEK 854
Query: 448 KSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKV 507
++L ++ E+ ++ K +ENQ+L VEE+ T E + K KE++ L +
Sbjct: 855 EALQSDLLEMKNANE-KTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
Query: 508 EILE-----NEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEH 562
E E E++ K SL ++ D + +LE+ IE L K +++ E
Sbjct: 914 EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE-------KECKEKEEK 966
Query: 563 LNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK- 621
+N+ + + A+ + KE + + E ++ S+ ++ R + + E YK
Sbjct: 967 INKI-----KLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKN 1021
Query: 622 ---EKGERAEELENE---LHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKL 675
E +++E+L+ E ++ E E L +++ N + CE I NS+ E ++
Sbjct: 1022 LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETI------NSDNEDLLARI 1075
Query: 676 KKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLENKELESEK 734
+ + K L Q+ +++ + +D+E E + + +K + + +L+ +L+ EK
Sbjct: 1076 ETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEK 1135
Query: 735 EQLKKG---LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEM 791
+QL+K LEL+K ++T + + + + L + L N N KI+ LE E++ +
Sbjct: 1136 KQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQ 1195
Query: 792 ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTT 851
+ +TLQ+ + L+ S ++ E+ + K L +T + D KQ E ++ L QA +K
Sbjct: 1196 KQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDH--LILQASLK--- 1250
Query: 852 LEENNVKIGNLEKENKTLSKEIGIYKESCVRL-KELEKENKELVKRATIDIKTLVTLRED 910
G LE +++ +YK + E K ++ L A +TL ++
Sbjct: 1251 --------GELEAS----QQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQR 1298
Query: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEI 970
+ + + + + + +T E E + +L +++ K + K+ E
Sbjct: 1299 VTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKN-----KSMSQAETEGAKQEREH 1353
Query: 971 KEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWE 1030
E I L+ +L++S N Q EL+T++ ++ L +R +
Sbjct: 1354 LEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHN------------------- 1394
Query: 1031 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQL-KQLETQNNNLQAQILALQ--- 1086
+ QET + +++++L ++ N +++E +QL Q E N+ + Q+ LQ
Sbjct: 1395 KMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEH 1454
Query: 1087 RQTV-SLQEQNTTLQTQNAKLQVENSTLN--SQSTSLMN----QNAQL-LIQQSSLENE- 1137
R+TV +LQ+Q + ++ Q +L+ E +T + S SL N +N L L+ ++ E
Sbjct: 1455 RKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREE 1514
Query: 1138 --------NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKN 1189
ESV +SL L KLE E L+ K + + +
Sbjct: 1515 GEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADH 1574
Query: 1190 LEVEHRDLEDRYNQLLKQ----KGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGE 1245
L R+ E L++Q K ++ LE+ + E+ LE + + + K E
Sbjct: 1575 LNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSE 1634
Query: 1246 NDRLNHTYSQLLK 1258
+RL + +L+
Sbjct: 1635 RERLLPVINTMLQ 1647
Score = 167 bits (423), Expect = 9e-41
Identities = 274/1183 (23%), Positives = 510/1183 (43%), Gaps = 167/1183 (14%)
Query: 278 KQELEQMEIE-LKRLQQENMNLLSDARS-ARMYRDELDALREKAVRVDKLESEVSRYKER 335
K +LE + E L + ++ M L+ A+S E++ LR K V + + ER
Sbjct: 19 KSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPV-TEGTGDIIKALTER 77
Query: 336 LHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKL 391
L + KA E+ LK++N ++ K +ED + D ELE+ ++ ++
Sbjct: 78 LDALLLEKAETEQQCLSLKKEN---IKMKQEVEDSVT---KMGDAHKELEQSHINYVKEI 131
Query: 392 HDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLG 451
+++ E R K E + L+ +++M+ L L +L + SE K L
Sbjct: 132 ENLKNELMAVRSKYSE---DKANLQKQLEEAMNTQLELSEQL----KFQNNSEDNVKKLQ 184
Query: 452 HEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
E+ ++ ++ + L T +E + TV ++ +E +Q K + L+
Sbjct: 185 EEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNI------IEANSQHYQKNINSLQ 238
Query: 512 NEIVQEKQSLQN------CQNLSKDLMKEKAQLEKTIETLREN-------SERQI-KILE 557
E++Q K Q CQ + + +A++ K E L+EN SE+ I K E
Sbjct: 239 EELLQLKAIHQEEVKELMCQ-IEASAKEHEAEINKLNE-LKENLVKQCEASEKNIQKKYE 296
Query: 558 QENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE- 616
E E+L + S+ Q +QI + ++ E ++++E +K L ++E + +K E
Sbjct: 297 CELENLRKATSNANQDNQICSILLQENTFVE-QVVNEKVKHLEDTLKELESQHSILKDEV 355
Query: 617 --LEHYKEKGER-AEELENELHHLEKENELLQKKITNLKITCEKIEA-LEQENSELEREN 672
+ + K K E A+ +++E H E E L+ KI L + E+ +E+ SEL N
Sbjct: 356 TYMNNLKLKLEMDAQHIKDEFFH---EREDLEFKINELLLAKEEQGCVIEKLKSELAGLN 412
Query: 673 RKLKKTLDSFKNLTFQL-ESLEKENSQLDE--------ENLELRRNVESLKCASMKMAQL 723
++ T++ L E +KE S+L+E E L L ++ LK + L
Sbjct: 413 KQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLK---EQCENL 469
Query: 724 QLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLE 783
Q E +E E L++ +E+L+ + K + QQ
Sbjct: 470 QQEKQEAILNYESLREIMEILQTEL----------------GESAGKISQEFESMKQQQA 513
Query: 784 SELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQ 843
S++ +L+ + +T + L + RL+ ++ S ++ +LE K L+++N
Sbjct: 514 SDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLL 573
Query: 844 QAEIKDTTLEENNVKIGNLEKEN-------KTLSKEIGIYKESCVRLKELEKENKELVKR 896
+DT L+E KI +L +E K +E+ + + C R + L E + V++
Sbjct: 574 SLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
Query: 897 A---TIDIKTLVTLREDLVSEKLKTQQMNND-LEKLTHELEKIGLNKERLLHDEQSTDDR 952
+++ V + E LK + N+ LEKL +++ + +KE L + +S +
Sbjct: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEE 693
Query: 953 YKLLESKLESTLKKSLE---------IKEEKIAALEARL----EESTNYNQQLR----QE 995
L S+ + L + LE I +E I LE +L EE N N+ L Q+
Sbjct: 694 NNKLSSE-KKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQK 752
Query: 996 LKTVKKNYEALKQ------RQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE 1049
L + Y LK+ EE+ V + GE + ++E + ++++E
Sbjct: 753 LFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGE--SLAKINEEKCNLAFQRDEKVLE 810
Query: 1050 VERNNATLQAEK----QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1105
+E+ LQ E + LK+ L+ E + L+ ++ +Q + +LQ ++ N K
Sbjct: 811 LEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEK 870
Query: 1106 LQVENSTLNSQSTSLMNQNAQLLIQQSSLENENES-VIKEREDLKSLYDSLIKDHEKLEL 1164
++EN Q+ + + +S + NE E IKE E+LK L + + EL
Sbjct: 871 TRLEN-----QNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAEL 925
Query: 1165 L-----HERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
+ + S +S L+ +NLE E ++ E++ N++ K++
Sbjct: 926 ILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKI-----------KLVA 974
Query: 1220 VEQEKML-LENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSK 1278
V+ +K L K +TV E + L E D+L+ + L++ E + K+LL +
Sbjct: 975 VKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAE-------SYKNLLLEYE 1027
Query: 1279 LEQTRLEAEFSKLKEQYQQLDITSTKLNN---QCELLSQLKGNLEEENRHLLDQIQTLML 1335
+ +L+ E + +++ + +L N QCE + +N LL +I+TL
Sbjct: 1028 KQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCE-------TINSDNEDLLARIETLQS 1080
Query: 1336 QNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMD 1378
+ L Q +E + + +DK EL +K + E+KI +
Sbjct: 1081 NAKLLEVQILEVQ-----RAKAMVDK--ELEAEKLQKEQKIKE 1116
Score = 164 bits (416), Expect = 6e-40
Identities = 267/1251 (21%), Positives = 528/1251 (42%), Gaps = 206/1251 (16%)
Query: 262 RLRQELEEKTEQLLDCKQELEQMEI----ELKRLQQENMNL--------------LSDAR 303
+++QE+E+ ++ D +ELEQ I E++ L+ E M + L +A
Sbjct: 101 KMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAM 160
Query: 304 SARM-YRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTM 362
+ ++ ++L V KL+ E+ + + + Y + + D + ET T
Sbjct: 161 NTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEK--KETVTQ 218
Query: 363 LEDQLEGTRARSDK-LHELEKENLQLKAKLHDMEM------------ERDMDRKKIEELM 409
L++ +E K ++ L++E LQLKA +H E+ E + + K+ EL
Sbjct: 219 LQNIIEANSQHYQKNINSLQEELLQLKA-IHQEEVKELMCQIEASAKEHEAEINKLNEL- 276
Query: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
+EN+ + Q ++ ++++ +E E + S A Q N++ S L +
Sbjct: 277 KENL---VKQCEASEKNIQKKYECELENLRKATSNANQD------NQICSILLQENTFVE 327
Query: 470 QSLTKTVEELRTTVDSVEGNAS----KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Q + + V+ L T+ +E S ++ M +L + +++E E++ L+
Sbjct: 328 QVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKI 387
Query: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA----EAR 581
N +L+ K + IE L+ K E N+ V SL+++ Q E
Sbjct: 388 N---ELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETF 444
Query: 582 VKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK--------EKGERAEELENE 633
+ D EKE L I+ + ++ EK++ E + E GE A ++ E
Sbjct: 445 LSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQE 504
Query: 634 LHHLEKE-----NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQ 688
++++ +EL QK L+ + +AL + + L+ EN KL + L
Sbjct: 505 FESMKQQQASDVHELQQK----LRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENT 560
Query: 689 LESLEKEN-------SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGL 741
+++L+++N SQ D EL + SL +E + +LK
Sbjct: 561 IKNLQEKNGVYLLSLSQRDTMLKELEGKINSL-------------TEEKDDFINKLKNSH 607
Query: 742 ELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQ-------LESELQDLEMENQ 794
E + KK ER E L +++++T++ +++ Q+ LE L++ + +Q
Sbjct: 608 EEMDNFHKKCEREERLILEL---GKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQ 664
Query: 795 TLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEE 854
L+K + ++K+ S+ E L E KSL +E ++L +KKQL ++ + Q E D L+E
Sbjct: 665 KLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKE--DVILKE 722
Query: 855 NNVKI-----------GNLEK--ENKTLS------------KEIG--------------- 874
+ ++ NL K EN+ + KE+G
Sbjct: 723 HITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNV 782
Query: 875 ----------IYKESC-------VRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLK 917
I +E C ++ ELEKE K L + + + + L +L D EK+
Sbjct: 783 LQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKV- 841
Query: 918 TQQMNNDLEKLTHELEKI--GLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKI 975
+ +LE++ E E + L + + +++ +++ L++ + S EI EK
Sbjct: 842 --LLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKE 899
Query: 976 AALEARLEESTNYNQQLRQ-ELKTVKKNYEALKQRQDEERMVQSSPPISGED-----NKW 1029
++E N L Q EL+ + LK + V++ P S ++
Sbjct: 900 KCF---IKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENL 956
Query: 1030 ERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQT 1089
E+E +E ++ K+K ++ ++ + + E Q +K +L+ L ++ + L A + L +
Sbjct: 957 EKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGA 1016
Query: 1090 VSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1149
S + + Q+ +L VE N+ + + QL + S+L + E++ + EDL
Sbjct: 1017 ESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQL--RNSTL--QCETINSDNEDLL 1072
Query: 1150 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKG 1209
+ ++L + + LE+ ++ K LE E E + +
Sbjct: 1073 ARIETLQSNAKLLEV----------QILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVN 1122
Query: 1210 QLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKN 1269
+LE+L+ L+ E++++ + E V + ++ N + Y +L+KE T+ N
Sbjct: 1123 ELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEI-ADYERLMKELNQKLTNKNN 1181
Query: 1270 ----LKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRH 1325
L+ + K +Q L+ E + L+ QQ + +TK+ +LL + K L + +
Sbjct: 1182 KIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIK---QLLVKTKKELADSKQA 1238
Query: 1326 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
D + L + LE + + +++ ++ L E+ +K K+ E +
Sbjct: 1239 ETDHL-ILQASLKGELEASQQQVEVYKIQ-------LAEITSEKHKIHEHL 1281
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 194 bits (492), Expect = 9e-49
Identities = 262/1226 (21%), Positives = 545/1226 (44%), Gaps = 160/1226 (13%)
Query: 256 AKAKIRRLRQELEEKTEQLLDCKQELEQ---------MEIELKRLQ--QENMNLLSDARS 304
A+ K+ RL +EL ++ + D K EL Q ++ EL ++Q +NM L + S
Sbjct: 189 AEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERES 248
Query: 305 ARMYRDELDALREK----AVRVDKLESEVSRYKERL----HDIEFYKARVEELKEDNQVL 356
++ +DE L+ + + +L SE+++ + + +++ K+ V EL + NQ L
Sbjct: 249 EKL-KDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTL 307
Query: 357 LETKTMLEDQLEGTRARSDKLHE-LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTL 415
T+ +L+ + + T+ E + K+N+Q D++ ++ R E + +
Sbjct: 308 --TENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHV 365
Query: 416 EMAQK----QSMDESL--------HLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLL 463
E+++K Q + E L HL E +Q+ + E E L E+N+L S+LL
Sbjct: 366 ELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQL-HSKLL 424
Query: 464 KLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQN 523
+ E + ++E R ++ K++ E++ L K+ LE ++ K+ + N
Sbjct: 425 ETERQLGEAHGRLKEQRQL------SSEKLMDKEQQVADLQLKLSRLEEQL---KEKVTN 475
Query: 524 CQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVK 583
L L K K Q QE + L Q+ ++ + +Q E ++
Sbjct: 476 STELQHQLDKTKQQ-------------------HQEQQALQQSTTAKLREAQNDLEQVLR 516
Query: 584 DI-EKENKI--LHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
I +K+ KI L ++++ +S +E E+ + +++ +GE A L+ L+++
Sbjct: 517 QIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQ--AGEGETAV-----LNQLQEK 569
Query: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
N LQ+++T L KLK +S K ++ E + Q+
Sbjct: 570 NHTLQEQVTQL--------------------TEKLKNQSESHK------QAQENLHDQVQ 603
Query: 701 EENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFK-KTERLEVSYQ 759
E+ LR A ++ L+ EL S+ + K+ + L K KTE L +
Sbjct: 604 EQKAHLR-------AAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEA 656
Query: 760 GLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENK- 818
+ LQ L+ + +Q + EL + + + L++ + +LE KE K
Sbjct: 657 AKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKE 716
Query: 819 ---SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGI 875
SLEQ+T +LE K+LE ++ ++ E L++ +LE LSK++ +
Sbjct: 717 KYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEM 776
Query: 876 YKE--SCVRLKELEKENKEL---VKRATIDIKTLVTLREDLVS----EKLKTQQMNNDLE 926
KE S RL +L+K+++ L ++ T + L++D + K++ +++NN ++
Sbjct: 777 EKEIVSSTRL-DLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQ 835
Query: 927 KLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES- 985
EL+K+ + KE L+ + + D+ + L+++ K E + +K A LE++
Sbjct: 836 TTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNS-KSEFEKENQKGKAAILDLEKTC 894
Query: 986 TNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE-------SQETTR 1038
QL+ +++ K + LK+ ++E+ ++S + E N + + ++ +
Sbjct: 895 KELKHQLQVQMENTLKEQKELKKSLEKEK--EASHQLKLELNSMQEQLIQAQNTLKQNEK 952
Query: 1039 ELLKVKDRLIEVERNNATLQAEKQALKTQLK----QLETQNNNLQAQILALQRQTVSLQE 1094
E +++ + E+++++ + + +AL+ +LK Q N LQ Q+ ++ + +E
Sbjct: 953 EEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKE 1012
Query: 1095 QNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDS 1154
+ + LQ K Q T + + ++LL + L++ E + +EDL S +
Sbjct: 1013 KISVLQNNYEKSQ---ETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQ 1069
Query: 1155 LIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL 1214
+ ++ ++ L +A+ + K L+ K L+ ++ + +L+ +K +L ++
Sbjct: 1070 IGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEI 1129
Query: 1215 EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLL 1274
E+ +K QEK + K +E + + + E L L+++ LQ +LK+ +
Sbjct: 1130 EE-IKCRQEKEI--TKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAV 1186
Query: 1275 NNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLM 1334
K Q L+ + K +E ++ + + +L S++K +H ++ + +
Sbjct: 1187 EQEKRNQQILKDQVKKEEE-----ELKKEFIEKEAKLHSEIKEKEVGMKKH--EENEAKL 1239
Query: 1335 LQNRTLLEQNMES-KDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGN 1393
T L +N+ + K + QR +++EL +Q + L +I + RR
Sbjct: 1240 TMQITALNENLGTVKKEWQSSQR----RVSELEKQTDDLRGEIAVLEATVQNNQDERRA- 1294
Query: 1394 WITLKMRKLIKSKKDINRERQKSLTL 1419
+ + +K + +I + + K L L
Sbjct: 1295 ----LLERCLKGEGEIEKLQTKVLEL 1316
Score = 185 bits (469), Expect = 4e-46
Identities = 291/1301 (22%), Positives = 566/1301 (43%), Gaps = 184/1301 (14%)
Query: 118 TEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWM- 176
+EE+KK L G Q K + GL D+ A + + Q++ Q F+++ M
Sbjct: 106 SEELKKELEKYQGLQQQEAKPD-------GLVTDSSAELQSLEQQLEEAQTENFNIKQMK 158
Query: 177 ------------EVTDM-SQEDIEPLLKNMALH-LKRLIDERDEHSETIIELSEE---RD 219
E+ D+ S+ D E L+ A + RL +E ++ + I +L E R
Sbjct: 159 DLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRP 218
Query: 220 GLH---FLPHASSSAQSPCGSPGMKRTESRQHLSVEL-------ADAKAKIRRLRQELEE 269
G+ L Q+ + ++R + L E A ++A I +LR EL +
Sbjct: 219 GIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAK 278
Query: 270 KTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELD---------------A 314
+++ QEL++++ + L Q+N L + +L+
Sbjct: 279 GPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQAT 338
Query: 315 LREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
L +K + +L+S +S + LH I + E E Q L E + +E + + +A
Sbjct: 339 LHQKDLDCQQLQSRLSASETSLHRIH---VELSEKGEATQKLKEELSEVETKYQHLKAEF 395
Query: 375 DKL----HELEKENLQLKA---KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
+L E E+ LQL++ +LH +E + + ++E +++ ++ MD+
Sbjct: 396 KQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQR--QLSSEKLMDKEQ 453
Query: 428 HLGWELEQISRTSE-LSEAPQKS--LGHEVNELTSSRLLKLEMENQSLTKTVE---ELRT 481
+ ++SR E L E S L H++++ + ++ + K E +L
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQ 513
Query: 482 TVDSVEGNASKILKMEKENQRLSKKVEILENE---IVQEKQSLQNCQNLSKDLMKEKAQL 538
+ + KI +E Q+ + + +LE E + + Q+ + + L ++ L
Sbjct: 514 VLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTL 573
Query: 539 EKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKE 598
++ + L E + Q + +Q E+L+ V + + +A+ RV +E L+ + E
Sbjct: 574 QEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLR-AAQDRVLSLETSVNELNSQLNE 632
Query: 599 TSSKLSKIEFE-KRQIKKELEHYKEKGERAEELENEL----HHLEKENELLQKKITNLKI 653
+ K+S+++ + K + + L K + +L+N L + L+ + + L K T L
Sbjct: 633 SKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQ 692
Query: 654 TCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESL 713
K++ ++ S+LE LK+ + + +L + E LE + +L+ ++LE++ + E
Sbjct: 693 VTAKLQDKQEHCSQLESH---LKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQA 749
Query: 714 KCASMKMAQLQLE--------NKELESEKE----------QLKKGLELLKASF-KKTERL 754
+ QL + +K+LE EKE + + LE +K K+ E
Sbjct: 750 LQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEK 809
Query: 755 EVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLE 814
++ Q + +Q + E N +IQ +ELQ ++ME + L L +K ++L
Sbjct: 810 QILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK------DKLS 863
Query: 815 KENKSLEQETSQLEKDKKQ-------LEKENKRLRQQAEIK-DTTLEENNVKIGNLEKEN 866
K + SL+ S+ EK+ ++ LEK K L+ Q +++ + TL+E +LEKE
Sbjct: 864 KVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEK 923
Query: 867 KT---LSKEIGIYKESCVR----LKELEKENK-------ELVKRATIDIKTLVTLREDLV 912
+ L E+ +E ++ LK+ EKE + EL + + K + L+ +L
Sbjct: 924 EASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELK 983
Query: 913 SEKLKTQQMNNDL-EKLTHELEKIGLNKER---LLHDEQSTDDRYKLLESKL---ESTL- 964
L+ ++ N L ++LT +++ KE+ L ++ + + + +K L+S ES L
Sbjct: 984 IAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043
Query: 965 --KKSLEIKEEKIAALEARLEESTNY---NQQLRQELKTVKKNYE---ALKQRQDEERMV 1016
++ L+ EEK++ + L + N +L QELKT K E A K++Q +ER
Sbjct: 1044 ATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCK 1103
Query: 1017 QSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNN 1076
+ +D + E+ +E +EL+ K +L E+E Q K++ N
Sbjct: 1104 ------ALQDIQKEKSLKE--KELVNEKSKLAEIEEIKC----------RQEKEITKLNE 1145
Query: 1077 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1136
L++ L ++ +L++ L Q +LQ + +L + + +N Q+L Q ++
Sbjct: 1146 ELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKA-AVEQEKRNQQILKDQ--VKK 1202
Query: 1137 ENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD 1196
E E + KE + ++ S IK+ E HE ++ I+ + ++NL ++
Sbjct: 1203 EEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQIT------ALNENLGTVKKE 1256
Query: 1197 LEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1256
+ ++ + + Q +DL + V + ++N E A + L GE
Sbjct: 1257 WQSSQRRVSELEKQTDDLRGEIAVLE--ATVQNNQDERRALLERCLKGEG---------- 1304
Query: 1257 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQ 1297
E E LQT L+ L+N+ L E L+ ++ Q
Sbjct: 1305 --EIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQ 1343
Score = 150 bits (379), Expect = 1e-35
Identities = 223/971 (22%), Positives = 421/971 (43%), Gaps = 154/971 (15%)
Query: 591 ILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELEN-------ELHHLEKENEL 643
+L + +++ + L + ++ ++KKELE Y+ ++ + + EL LE++ E
Sbjct: 87 LLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEE 146
Query: 644 LQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL--------TFQLESLEKE 695
Q + N+K + + EQ+ ++L E +K D ++L T E L KE
Sbjct: 147 AQTENFNIK---QMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKE 203
Query: 696 NSQLDEENLEL--RRNVESLKCASMKMAQLQ--LENKELESEKE---------------- 735
+ + + EL R +E + ++ Q+Q ++N LE E+E
Sbjct: 204 ATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYA 263
Query: 736 -----------QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTL---ENSNKKIQQ 781
+L KG + + ++ ++L+ S L +NQ L + L E K+++
Sbjct: 264 SSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEE 323
Query: 782 -----------LESELQDLEMENQTLQKNLEELKISSKR----LEQLEKENKSLEQETSQ 826
+++ L +++ Q LQ L + S R L + + + L++E S+
Sbjct: 324 KHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSE 383
Query: 827 LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKEL 886
+E + L+ E K+L+QQ E K+ + +I L + +++G E+ RLKE
Sbjct: 384 VETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLG---EAHGRLKEQ 440
Query: 887 EKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDE 946
+ + E + + L L+ + E+LK + N+ +L H+L+K + +
Sbjct: 441 RQLSSEKLMDKEQQVADL-QLKLSRLEEQLKEKVTNS--TELQHQLDKTKQQHQEQQALQ 497
Query: 947 QSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA- 1005
QST + + ++ LE L++ + K++KI LEA L++S L +E + + +A
Sbjct: 498 QSTTAKLREAQNDLEQVLRQ-IGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAG 556
Query: 1006 ------LKQRQDEERMVQSSPPISGEDNKWERES------------QETTRELLKVKDRL 1047
L Q Q++ +Q E K + ES QE L +DR+
Sbjct: 557 EGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRV 616
Query: 1048 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ-RQTVSLQEQNTTLQTQNAKL 1106
+ +E + L ++ K ++ QL+ Q +L+ + +T + L T L
Sbjct: 617 LSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNAL 676
Query: 1107 QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLE-LL 1165
Q + LN +T L A+L +Q ++ ES +KE K Y SL + E+LE +
Sbjct: 677 QDKQQELNKITTQLDQVTAKLQDKQEHC-SQLESHLKE---YKEKYLSLEQKTEELEGQI 732
Query: 1166 HERQASEYESLISKHGTLKSAH-----------------KNLEVEHRDLEDRYNQLLKQK 1208
+ +A E SK L+ K LE+E + L K+
Sbjct: 733 KKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKS 792
Query: 1209 GQLEDL-EKMLKVEQEKMLLENKNHETVAAEYKKLCGE-NDRLNHTYSQLLK---ETEVL 1263
LE + +K+ K E+EK +L+ ++ ET++ E K E N+R+ T ++L K E E L
Sbjct: 793 EALESIKQKLTKQEEEKQILK-QDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEAL 851
Query: 1264 QTDHKNLKSLLN--NSKLEQTRLEAEFSKLKEQYQQLDITST----------KLNNQCEL 1311
T+ +K L+ + L+ ++ E E K + LD+ T ++ N +
Sbjct: 852 MTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKE 911
Query: 1312 LSQLKGNLEEEN------RHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNEL 1365
+LK +LE+E + L+ +Q ++Q + L+QN + E++Q +NEL
Sbjct: 912 QKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEK-------EEQQLQGNINEL 964
Query: 1366 RR---QKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPT 1422
++ QK+K E + + K ++ ++L ++ +++ E++K L
Sbjct: 965 KQSSEQKKKQIEALQGELKI----AVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNN 1020
Query: 1423 RSDSSEGFLQL 1433
S E F QL
Sbjct: 1021 YEKSQETFKQL 1031
Score = 63.2 bits (152), Expect = 2e-09
Identities = 114/504 (22%), Positives = 212/504 (42%), Gaps = 61/504 (12%)
Query: 59 LESQRVNKKVNNDASLRMHNLSILVRQIKFYYQETLQ-----QLIMMSLPNVLIIGKNPF 113
L+ ++ K++ + ++M N +++K ++ + +L + S+ LI +N
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 114 SEQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDL 173
+ EE ++L + ++K++ IE +QG + K AV + Q+ +
Sbjct: 948 KQNEKEE-QQLQGNINELKQSSEQKKKQIEALQG---ELKIAVLQKTELENKLQQQL--T 1001
Query: 174 QWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQS 233
Q + +E I L N + + + EL R L + S AQ
Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQE 1061
Query: 234 PCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQ 293
S + ++ L EL AKA L Q+ +K +QL + + L+ ++ E ++
Sbjct: 1062 DLIS-NRNQIGNQNKLIQELKTAKAT---LEQDSAKKEQQLQERCKALQDIQKEKSLKEK 1117
Query: 294 ENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN 353
E +N +S +E+ +EK + KL E+ + H +E K + LK+
Sbjct: 1118 ELVN----EKSKLAEIEEIKCRQEK--EITKLNEEL-----KSHKLESIK-EITNLKDAK 1165
Query: 354 QVLLETKTMLEDQLEGTRA------RSDKL---------HELEKENLQLKAKLHDMEMER 398
Q+L++ K L+ + + +A R+ ++ EL+KE ++ +AKLH E+
Sbjct: 1166 QLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEK 1225
Query: 399 DMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELT 458
++ KK EE E +T+++ ++ W+ Q R SEL E L E+ L
Sbjct: 1226 EVGMKKHEE-NEAKLTMQITALNENLGTVKKEWQSSQ-RRVSEL-EKQTDDLRGEIAVLE 1282
Query: 459 SS-------------RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSK 505
++ R LK E E + L V EL+ +D+ + + ++ +ENQ L
Sbjct: 1283 ATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNT---TAAVQELGRENQSLQI 1339
Query: 506 KVEILENEIVQEKQSLQNCQNLSK 529
K N E +QNC K
Sbjct: 1340 KHTQALNRKWAEDNEVQNCMACGK 1363
Score = 47.8 bits (112), Expect = 1e-04
Identities = 56/254 (22%), Positives = 120/254 (47%), Gaps = 23/254 (9%)
Query: 1204 LLKQKGQLEDLEKMLKVEQ---EKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET 1260
LL+Q +++DL+ LK E+ E++ E + ++ + + K G + L ++
Sbjct: 87 LLRQ--EVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQL 144
Query: 1261 EVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCEL-LSQLKGNL 1319
E QT++ N+K + + + + +L E + +K +Y + L E +++L L
Sbjct: 145 EEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDE----ERSLREAAEQKVTRLTEEL 200
Query: 1320 EEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLN-ELRRQKEKLEE---K 1375
+E + D ++T +LQ + + + K+L V+ +D + E R+ EKL++ K
Sbjct: 201 NKEATVIQD-LKTELLQRPGIEDVAVLKKELVQVQT--LMDNMTLERERESEKLKDECKK 257
Query: 1376 IMDQYKFYDPSPPRRRGNW------ITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEG 1429
+ QY + + + R + + +++L K K +N QK+ TLT +
Sbjct: 258 LQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQD 317
Query: 1430 FLQLPHQDSQDSSS 1443
+ +L + +++S S
Sbjct: 318 YTKLEEKHNEESVS 331
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 191 bits (486), Expect = 4e-48
Identities = 258/1188 (21%), Positives = 523/1188 (44%), Gaps = 123/1188 (10%)
Query: 253 LADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE--NMNLLSDARSARMYR- 309
L + K K + Q LE + LL ++ + ELK LQ+E MNLL+ + R
Sbjct: 1852 LEEEKQKNKEFSQTLENEKNTLLS---QISTKDGELKMLQEEVTKMNLLNQQIQEELSRV 1908
Query: 310 --------DELDALREKAV-RVDKLESEVSRYKERLHDIEF-----------YKARVEEL 349
+E D L E+ + ++ +L + Y + + D + K V EL
Sbjct: 1909 TKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKNLKKCVSEL 1968
Query: 350 KEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELM 409
+E+ Q L++ KT +E ++ R + L +++ + K H E++ + K+ E
Sbjct: 1969 EEEKQQLVKEKTKVESEI-----RKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVKQ 2023
Query: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVN-------ELTSSRL 462
+ + +K S E E Q +L E +++L V EL S ++
Sbjct: 2024 LQKDCIRYQEKISALERTVKALEFVQTESQKDL-EITKENLAQAVEHRKKAQAELASFKV 2082
Query: 463 LKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQ 522
L + ++++ + L+ + S +M+++++ L +++E E + ++EK+++Q
Sbjct: 2083 LLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQ 2142
Query: 523 NCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISA---E 579
+ L +EK LE+TI ++ ++ K ++Q E+L+ TV+ L ++ + +
Sbjct: 2143 EKLDA---LRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQD 2199
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEK 639
R + I++ K + SK +I ++ + ++ EEL+ + LE
Sbjct: 2200 DRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH 2259
Query: 640 ENELLQKKI-TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQ 698
+ ++ + K T +++ + + L+ EN EL + + + S +N +L LE E
Sbjct: 2260 DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQN---ELAKLESELKS 2316
Query: 699 LDEENLELRRNVESLKCASMK------MAQLQLENKELESEKEQLKKGLELLKASFKKTE 752
L ++ +L ++E KC K + Q + + + + EQL+ L+ AS + T
Sbjct: 2317 LKDQLTDLSNSLE--KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQ---ASRELTS 2371
Query: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQ 812
RL ++ ++++ Q++ L + IQ +EL+ Q K ++EL+ + E+
Sbjct: 2372 RL---HEEINMKEQKIISLLSGKEEAIQVAIAELR------QQHDKEIKELENLLSQEEE 2422
Query: 813 ----LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE--IKDTTLEENNVK--IGNLEK 864
LE+ENK +T+QL + K ++KEN + + Q + +K + +N+ +G+ ++
Sbjct: 2423 ENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQ 2482
Query: 865 ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQ-QMNN 923
+ + + I E ++E EN +L + +I+ L + +DL SE K ++
Sbjct: 2483 LEE---RHLSIILEKDQLIQEAAAENNKLKE----EIRGLRSHMDDLNSENAKLDAELIQ 2535
Query: 924 DLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLE 983
E L + +++LL + + + +KLE LK+S E E+ + A E
Sbjct: 2536 YREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQE 2595
Query: 984 ESTNYNQQLRQELKTVKKNYEALKQR----QDEERMVQSSPPISGEDNKWERES---QET 1036
E Q L +E++++K + L ++ Q+E + + ++ + R S +
Sbjct: 2596 EK----QDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSS 2651
Query: 1037 TRELLKVKDRLIEVERNNATLQAE-KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQ 1095
+ + ++++ L+ V++ A E + LK +LK L ++ + + + L
Sbjct: 2652 QKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711
Query: 1096 NTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSL 1155
++ + + EN L +Q S SSL+N + +E ++LK YD+
Sbjct: 2712 LVEMEQKLLMVTKENKGLTAQIQSFGRS-------MSSLQNSRDHANEELDELKRKYDAS 2764
Query: 1156 IKDHEKLE----LLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL 1211
+K+ +L+ L ER A E+ S + T +++ +LE ++ L + QLL QL
Sbjct: 2765 LKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQL 2824
Query: 1212 EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK 1271
ED ++ + M + + E +K + + +Q +Q+ K +
Sbjct: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMS 2884
Query: 1272 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQ 1331
SL N ++ RL E L++QY Q +N + L LK L+E D+ +
Sbjct: 2885 SLQN----DRDRLLKELKNLQQQYLQ-------INQEITELHPLKAQLQEYQ----DKTK 2929
Query: 1332 TLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
+ L ++N+ + H + + RR KE+ I D+
Sbjct: 2930 AFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDK 2977
Score = 185 bits (470), Expect = 3e-46
Identities = 319/1592 (20%), Positives = 663/1592 (41%), Gaps = 212/1592 (13%)
Query: 249 LSVELADAKAKIRRLRQELEEKTEQLLD--------------CKQELEQMEIELKRLQQE 294
+ ++ ++ IR L+ +L+ K ++L+ Q L Q E+E+ ++ Q
Sbjct: 822 VQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQL 881
Query: 295 NMNLLSDARSARMYRDELD--------ALREKAVRVDK----LESEVSRYKERLHDIE-F 341
+ D + + +E D ++ EK V++++ L E+ KE+L+ +
Sbjct: 882 LLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRA 941
Query: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKL-HE---LEKENLQLKAKLHDMEME 397
+A+ E+++EDN+V K ++ + ++L HE L+KEN Q K KL +
Sbjct: 942 EEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALIN 1001
Query: 398 RDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457
R +++ L EE L+ K+ + S E+E+ E SE S E+
Sbjct: 1002 RKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIY 1061
Query: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK--MEKENQRLSKKVEILENEIV 515
+ + E+E Q + K +EE + + ++ + +K NQ + EI EN+ +
Sbjct: 1062 LKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAI 1121
Query: 516 QEKQSLQNCQNLSKD---LMKEKAQLEK----TIETLRENSERQIKILEQENEHLNQTVS 568
+K N D L+KE + + E + E +I LE+E E L + +
Sbjct: 1122 IQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKL- 1180
Query: 569 SLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE 628
Q + S +A +K +++ + L E +K+ ++++ E + E+ + E
Sbjct: 1181 ---QEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQ----------EQFDEQSKENE 1227
Query: 629 ELENELHHLE-KENELLQKKI--TNLKITCEKIEALEQENSELERENRKLKKTLDSFKNL 685
+ ++L L+ + E + K+ T+ + +C LE+ + E + L+S NL
Sbjct: 1228 NIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFK-ATEQHHTQPVLES--NL 1284
Query: 686 TFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLK 745
S ++ S L +AQ++ + KE+E+EK +L+ +
Sbjct: 1285 CPDWPSHSEDASALQ---------------GGTSVAQIKAQLKEIEAEKVELELKVSSTT 1329
Query: 746 ASF-KKTERL-----EVSYQGLDIEN------------QRLQKTLENSNKKIQQLESELQ 787
+ KK+E + +++ QGL+IE+ + LQ+ LE+S +I LE L+
Sbjct: 1330 SELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLE-HLR 1388
Query: 788 DLEMENQTLQKNLEELKISSKRLE-QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
+L+ + LQK + + + L QL ++ +L + +++ + + ++ + +L QA+
Sbjct: 1389 ELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAK 1448
Query: 847 IKDTTLEENNVKIGNLEKENKTLSKEIGIYKE-------SCVRLKELEKENKELVKRATI 899
D +++ V++ ++++ + + +E ++ + + KE KENK L + ++
Sbjct: 1449 EHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSL 1508
Query: 900 DIKTLVTLREDLVSEKLKTQQMNND-------LEKLTHELEKIGLNKERLLHDEQSTDDR 952
T+ L + L + + N + L L E +K+ +R L + QS
Sbjct: 1509 ARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSS 1568
Query: 953 YKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY---NQQLRQELKTVKKNYEALKQR 1009
+ L+ LE + ++ +E + +++ EST + +++L++E + + ++YE +
Sbjct: 1569 CESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNE 1628
Query: 1010 QDE-----ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQAL 1064
+ E + Q + G+ E +ET ++L + + + E++ KQ
Sbjct: 1629 AERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQ-- 1686
Query: 1065 KTQLKQLETQNNNLQAQIL----ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL 1120
++ +LE +N+ L+A++ + +L N +++ + ++++E TL+ + SL
Sbjct: 1687 -QKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSL 1745
Query: 1121 MNQNAQLLIQQSSLENENESVIKEREDLKSL--YDSLIKDHEKLELLHERQASEYESL-I 1177
M++ L + L+++ E + ++ +L++ +D+ E+ + E +SL +
Sbjct: 1746 MSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSM 1805
Query: 1178 SKHGT-------LKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENK 1230
S T KSA+ + + D N L+Q QL+ E++ +E+EK K
Sbjct: 1806 STRPTCSESVPSAKSANPAVSKDFSS-HDEINNYLQQIDQLK--ERIAGLEEEK----QK 1858
Query: 1231 NHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFS- 1289
N E + L + + LL + + K L+ + L +++ E S
Sbjct: 1859 NKEF-----------SQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSR 1907
Query: 1290 --KLKE-QYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD-QIQTLMLQNRTLLEQNM 1345
KLKE ++ D +L NQ L++L G++ + + D QI+ +L++ E
Sbjct: 1908 VTKLKETAEEEKDDLEERLMNQ---LAELNGSIGNYCQDVTDAQIKNELLES----EMKN 1960
Query: 1346 ESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLK-MRKLIK 1404
K + +E+ + +L ++K K+E +I +Y + GN K +++L+K
Sbjct: 1961 LKKCVSELEEEK-----QQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLK 2015
Query: 1405 SKKDINRERQKSLTLTPTRSDSSE---GFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSS 1461
K+ ++ QK + + E L+ +SQ + +L Q + +K +
Sbjct: 2016 EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENL--AQAVEHRKKA 2073
Query: 1462 MVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGQWTGSTENLEVPDDISTGK 1521
L L + + + + + Q E+LE + + K
Sbjct: 2074 QAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEK 2133
Query: 1522 RRKELGAMAFSTTAINFSTVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHA 1581
KE M A+ V+ Q+ NK + + Q D + T
Sbjct: 2134 HLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQL--QENLDSTVTQLAAFT 2191
Query: 1582 SRPASLDSGR---------------TSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFS 1626
+SL R + + L E + +Q R S E
Sbjct: 2192 KSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELK 2251
Query: 1627 -----LLHDHEAWSSSGSSPIQYLKRQTRSSPVLQHKISETLESRHHKIKTGSPGSEVVT 1681
L HD + W S + +Q LQ K+ +TL+ + ++ + T
Sbjct: 2252 INISRLEHDKQIWESKAQTEVQ-----------LQQKVCDTLQGENKELLS----QLEET 2296
Query: 1682 LQQFLEESNKLTSVQIKSSSQENLLDEVMKSL 1713
+ N+L ++ + S ++ L ++ SL
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQLTDLSNSL 2328
Score = 182 bits (461), Expect = 3e-45
Identities = 282/1373 (20%), Positives = 579/1373 (42%), Gaps = 185/1373 (13%)
Query: 136 QKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMAL 195
Q+ ++ ERI GL+ + + + N++N L + D + ++ + M L
Sbjct: 1840 QQIDQLKERIAGLEEEKQKN--KEFSQTLENEKNTL-LSQISTKDGELKMLQEEVTKMNL 1896
Query: 196 HLKRLIDERDEHSETIIELSEERDGLHF-LPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
+++ +E ++ EE+D L L + + G+ T+++ + EL
Sbjct: 1897 LNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ--IKNELL 1954
Query: 255 DAKAK-IRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDEL- 312
+++ K +++ ELEE+ +QL+ +E ++E E+++ E + + + EL
Sbjct: 1955 ESEMKNLKKCVSELEEEKQQLV---KEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQ 2011
Query: 313 DALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLE-TKTMLEDQLEGTR 371
+ L+EK V +L+ + RY+E++ +E +E ++ ++Q LE TK L +E +
Sbjct: 2012 ELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRK 2071
Query: 372 ARSDKLHELEKENLQLKAKLHDMEMERDM---DRKKIEELMEENMTLEMAQKQSMDESLH 428
+ + E K L D + E D K+++ ++ N +Q + DE L
Sbjct: 2072 -------KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLE 2124
Query: 429 LGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
L +A +K L + N +L L E L +T+ E++ T++
Sbjct: 2125 -----------RRLEQAEEKHLKEKKN--MQEKLDALRREKVHLEETIGEIQVTLN---- 2167
Query: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
K +KE Q+L + ++ ++ +S+ + Q+ ++ E + E+ ++
Sbjct: 2168 ------KKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQS 2221
Query: 549 SERQIKILEQE--------------NEHLNQTVSSLRQRSQI---SAEARVK-------D 584
E +I++ E E L +S L QI A+ V+
Sbjct: 2222 KEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDT 2281
Query: 585 IEKENKILHESIKET-------SSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHL 637
++ ENK L ++ET ++L+K+E E + +K +L E+ +E + L +
Sbjct: 2282 LQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGI 2341
Query: 638 EKENELLQKKITNLKITCEKIEALEQENSEL-----ERENRKLKKTLD--SFKNLTFQ-- 688
++ E I N K + E++E Q + EL E N K +K + S K Q
Sbjct: 2342 IRQQEA---DIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398
Query: 689 -----------LESLEKENSQLDEENLELRR-NVESLKCASMKMAQLQLENKELESEKEQ 736
++ LE SQ +EEN+ L N +++ + M L+ KE +K Q
Sbjct: 2399 IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ 2458
Query: 737 LKKGLELLKASFKKTERLEVSYQGLDI--------ENQRLQKTLENSNK---KIQQLESE 785
L ++ + + +R+ YQ L+ ++Q +Q+ +NK +I+ L S
Sbjct: 2459 LDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSH 2518
Query: 786 LQDLEMENQTLQKNLEE----------LKISSKR--LEQLEKENKSLEQETSQLEKDKKQ 833
+ DL EN L L + +K S ++ LE ++NK LE + ++LE+ K+
Sbjct: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKE 2578
Query: 834 LEKENKRLRQ-----QAEIKDTT--LEENNVKIGNLEKENKTLSKE--IGIYKESCVRLK 884
E+ N+ LR+ Q E +D + +E V I L ++ L +E +G+Y +LK
Sbjct: 2579 SEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYH---AQLK 2635
Query: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE-KLTHELEKIGLNKERLL 943
E+E L + K + L E+LV + + + ++E KL EL+ + + +
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMR 2695
Query: 944 HDEQSTDDRYKLLESKLESTLKKSLEIKEE------KIAALEARLEESTNYNQQLRQELK 997
++ ++ ++R L L +K L + +E +I + + N +EL
Sbjct: 2696 NETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELD 2755
Query: 998 TVKKNYEA------------LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD 1045
+K+ Y+A L R+ + + +++ ++ + ++ ++LL +
Sbjct: 2756 ELKRKYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSLSHLEKLNQQLLSKDE 2815
Query: 1046 RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1105
+L+ + + Q+ + L+ + ++L ++ ++ Q T A+
Sbjct: 2816 QLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAE 2875
Query: 1106 LQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK---L 1162
+Q +L +SL N +LL + +L+ + + +E +L L L + +K
Sbjct: 2876 VQ----SLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAF 2931
Query: 1163 ELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQ-LEDLEKMLKVE 1221
+++ E E S + L+ + E+ R ++++Y + K Q L L+ +++
Sbjct: 2932 QIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIR-- 2989
Query: 1222 QEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ-LLKETEVLQTDHKNLKSLLNNSKLE 1280
++ + + + +Y++ + SQ L+ ETE+L+T + ++ +L
Sbjct: 2990 --ELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELR 3047
Query: 1281 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLM------ 1334
+L + FS+L E+ L I + Q G+L L Q+Q L
Sbjct: 3048 IQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPLNI 3107
Query: 1335 ------------LQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
+ ++ E+ E + F Q+Q + E+ ++ LEE+
Sbjct: 3108 DVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEE 3160
Score = 178 bits (451), Expect = 5e-44
Identities = 343/1701 (20%), Positives = 713/1701 (41%), Gaps = 239/1701 (14%)
Query: 142 IERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLI 201
++ I+ + + V++ E+T E VF LQ E + +IE L K +
Sbjct: 1311 LKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ--EQINKQGLEIESL--------KTVS 1360
Query: 202 DERDEHSETIIELSEERD----GLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAK 257
E + H+E++ + E GL L K+ E +LS +L++ +
Sbjct: 1361 HEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDE-LQKLISKKEEDVSYLSGQLSEKE 1419
Query: 258 AKIRRLRQELEEKTE-----------QLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
A + +++ E+ E+ + Q + + ++Q+++EL ++Q+ + ++R+ +
Sbjct: 1420 AALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQ 1479
Query: 307 MYRDELDAL---REKAVRVDK-LESEVS-------RYKERLHDIEFYKARVEELKEDNQV 355
+ +L A R++A++ +K L+ E+S R + L D+E ++V ++
Sbjct: 1480 QIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVE---SQVSAQNKEKDT 1536
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQ-----LKAKLHDMEMERDMDRKKIEELME 410
+L +L+++ + D+ LE ++L LK L + +++ K+IE L
Sbjct: 1537 VLGRLALLQEERDKLITEMDR-SLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKS 1595
Query: 411 ENMTLEMAQKQSMDESLHLGWEL-----EQISRTSELSEAPQKSLGHEVNEL------TS 459
+ E + Q + L +E+ E +S +E + +++ E EL T
Sbjct: 1596 SKIA-ESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTE 1654
Query: 460 SRLLKLEMENQSLTKTVEELRTTVDS-VEGNASKILKMEKENQRLSKKVEILENEIVQEK 518
+ + E + Q + +EE++ + + KIL++E+EN RL +V + K
Sbjct: 1655 ANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTA---K 1711
Query: 519 QSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQ--I 576
+ ++ + + + +E +++ ETL ++ + L E + L++ V L+ + + +
Sbjct: 1712 ECMETLLSSNASMKEELERVKMEYETL----SKKFQSLMSEKDSLSEEVQDLKHQIEGNV 1767
Query: 577 SAEARVKDIEKENKILH------ESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEEL 630
S +A ++ EK + + +SI + + + R E + A
Sbjct: 1768 SKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSK 1827
Query: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN-LTFQL 689
+ H ++ N LQ+ I LK E+I LE+E +++N++ +TL++ KN L Q+
Sbjct: 1828 DFSSH--DEINNYLQQ-IDQLK---ERIAGLEEE----KQKNKEFSQTLENEKNTLLSQI 1877
Query: 690 ESLEKENSQLDEENLELRRNVESLKCASMKMAQL-QLENKELESEKEQLKKGLELLKASF 748
+ + E L EE ++ + ++ ++ +L + +E + +E+L L L S
Sbjct: 1878 STKDGELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSI 1937
Query: 749 KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSK 808
+ Q I+N+ L+ ++N K + +LE E Q L E ++ + + +
Sbjct: 1938 GNYCQDVTDAQ---IKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKI 1994
Query: 809 RLEQLEKENKSLEQETSQLEKDK----KQLEKENKRLRQQAEIKDTTLEENNVKIGNLEK 864
+ Q E NKS +E +L K+K KQL+K+ R +++ + T++ LE
Sbjct: 1995 QGAQKEPGNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKA-------LEF 2047
Query: 865 ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSE---------K 915
K++ I KE+ + E K+A ++ + L +D SE K
Sbjct: 2048 VQTESQKDLEITKENLAQAVEHR-------KKAQAELASFKVLLDDTQSEAARVLADNLK 2100
Query: 916 LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKI 975
LK + +N + +K + RL E+ K ++ KL++ ++ + + EE I
Sbjct: 2101 LKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHL-EETI 2159
Query: 976 AALEARLEESTNYNQQLRQELKTVKKNYEALKQ-----RQDEERMVQSSPPISGEDNKWE 1030
++ L + QQL++ L + A + + D +R++ E KWE
Sbjct: 2160 GEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVID-------EAKKWE 2212
Query: 1031 RESQETTRELLKVKDRLIEVERNNATLQAEK--------QALKTQLKQLETQ----NNNL 1078
R+ + ++ K+ I ++ +N ++ ++ + LK + +LE +
Sbjct: 2213 RKFSDA----IQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKA 2268
Query: 1079 QAQILALQRQTVSLQEQNTTL--------------QTQNAKLQVENSTLNSQSTSLMNQN 1124
Q ++ Q+ +LQ +N L Q + AKL+ E +L Q T L N
Sbjct: 2269 QTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSL 2328
Query: 1125 AQLLIQQSSLENENESVIKEREDLKSLYDSLIKD----HEKLELLHERQASEYESLISKH 1180
+ Q+ +LE + ++ K Y+ L D E LHE + + +IS
Sbjct: 2329 EKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIIS-- 2386
Query: 1181 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYK 1240
L + ++V +L ++++ +K +LE+L + + E+E ++LE +N + V
Sbjct: 2387 -LLSGKEEAIQVAIAELRQQHDKEIK---ELENL--LSQEEEENIVLEEENKKAV----- 2435
Query: 1241 KLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDI 1300
D+ N QL++ + ++ ++ K+ L++ + L+ + ++ YQQL+
Sbjct: 2436 ------DKTN----QLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEE 2485
Query: 1301 TSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYID 1360
+ + + L Q EN L ++I+ L L +N + E QY +
Sbjct: 2486 RHLSIILEKDQLIQ---EAAAENNKLKEEIRGLRSHMDDLNSENAK----LDAELIQYRE 2538
Query: 1361 KLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSL-TL 1419
LN++ K+ ++++++ + + K+ + +K ++ N + ++S L
Sbjct: 2539 DLNQVITIKDSQQKQLLEVQLQQNKELENKYA-----KLEEKLKESEEANEDLRRSFNAL 2593
Query: 1420 TPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKD 1479
+ D S+ L SQ + V +L++ TLG + L+ + ++
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQV--TALQEEGTLGLYHAQ---------LKVKEEEVH 2642
Query: 1480 KMKACYRRSMSMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFS 1539
++ A + S ++ ++ Q + + E+ D K +KEL + +
Sbjct: 2643 RLSALFSSSQKRIAELEEELVCVQKEAAKKVGEIED-----KLKKELKHLHHDAGIMRNE 2697
Query: 1540 TVNSS----------AGFRSKQLVNNKDTTSF-EDISPQGVSDDSSTGSRVHASRPASLD 1588
T + K L+ K+ I G S S SR HA+ LD
Sbjct: 2698 TETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANE--ELD 2755
Query: 1589 SGRTSTSNSNNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQ 1648
+ S L ++K + N+ R S FS+ E + S ++ L +Q
Sbjct: 2756 ELKRKYDASLK--ELAQLKEQGLLNRERDALLSETAFSMNSTEE----NSLSHLEKLNQQ 2809
Query: 1649 TRSSPVLQHKISETLESRHHKIKTGSPG-----SEVVTLQQFLEESNKLTSVQIKSSSQE 1703
S +S LE ++++++ S +E L LE+ K + +S++Q
Sbjct: 2810 LLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQP 2869
Query: 1704 NLLDEVMKSLSVSSDFLGKDK 1724
+ ++SL + L D+
Sbjct: 2870 STSPAEVQSLKKAMSSLQNDR 2890
Score = 169 bits (427), Expect = 3e-41
Identities = 276/1342 (20%), Positives = 555/1342 (41%), Gaps = 237/1342 (17%)
Query: 257 KAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALR 316
+A ++++ Q L++KT Q+ + E+ + + +++L N +DA D + ++
Sbjct: 1091 QALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSN----TDASDG----DSVALVK 1142
Query: 317 EKAVRVDKLESEVSRYKERLHD--IEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARS 374
E V +K L + + K + + K+ + L K +L+ E R
Sbjct: 1143 ETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKER--- 1199
Query: 375 DKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE 434
L +E Q K + ++ + D K+ E + ++ L++ ++S+D L + E
Sbjct: 1200 ----HLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255
Query: 435 QISRTSELSEAPQKSLG-HEVNELTSSRLLK---LEMENQSLTK---TVEELRTTVDSVE 487
S T L E K+ H + S L E+ S + +V +++ + +E
Sbjct: 1256 SCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIE 1315
Query: 488 GNASKI-LKMEKENQRLSKKVEI---LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIE 543
++ LK+ L+KK E L+ +I ++ +++ + +S + L++ +E
Sbjct: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
Query: 544 T-------------LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN- 589
+ L+ + K++ ++ E ++ L ++ + + + IE+E+
Sbjct: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435
Query: 590 -KILHESI----KETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELH-------HL 637
K LH + KE ++ +++ E ++K++ E E+ ++++ +L
Sbjct: 1436 IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEA 1495
Query: 638 EKENELLQKKITNLKITCEKI-EALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696
KEN+ LQ++++ + T E++ ++L S++ +N++ L L + + L E
Sbjct: 1496 LKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEM 1555
Query: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASF-------- 748
+ EN L + ESLK A LE L +KE+L K +E LK+S
Sbjct: 1556 DRSLLENQSLSSSCESLKLA--------LEG--LTEDKEKLVKEIESLKSSKIAESTEWQ 1605
Query: 749 -------KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
K+ E L SY+ + E +R+Q +E ++ Q+L +L+ E + +K L+
Sbjct: 1606 EKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQ 1665
Query: 802 ELKISSKRL-EQLEKENKSLEQETSQLEKDKKQLEKE------------------NKRLR 842
E + + + E++ K KS +Q+ +LE++ +L E N ++
Sbjct: 1666 EAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMK 1725
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESC-------VRLKELEKENK---- 891
++ E E + K +L E +LS+E+ K L+ EK +
Sbjct: 1726 EELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNV 1785
Query: 892 ----------ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDL---EKLTHELEKIGLN 938
E ++ ++ + T T E + S K ++ D +++ + L++I
Sbjct: 1786 TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQL 1845
Query: 939 KERL--LHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 996
KER+ L +E+ + + ++TL + K+ ++ L+ + + NQQ+++EL
Sbjct: 1846 KERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL 1905
Query: 997 KTVKKNYEALKQRQD--EERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNN 1054
V K E ++ +D EER++ ++G + ++ + ++K+ L+E E N
Sbjct: 1906 SRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDA-----QIKNELLESEMKN 1960
Query: 1055 -----ATLQAEKQAL----------------------------KTQLKQLETQNNNLQAQ 1081
+ L+ EKQ L K+ K+L+ Q +
Sbjct: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
Query: 1082 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1141
+ LQ+ + QE+ + L+ L+ + AQ + + + E S
Sbjct: 2021 VKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASF 2080
Query: 1142 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRY 1201
+D +S ++ D+ KL+ + S ES+ S+ +K ++LE R LE
Sbjct: 2081 KVLLDDTQSEAARVLADNLKLK---KELQSNKESVKSQ---MKQKDEDLE---RRLEQAE 2131
Query: 1202 NQLLKQKGQLEDLEKMLKVEQEKMLLENKNHE---TVAAEYKKLCGENDRLNHTYSQLLK 1258
+ LK+K ++ EK+ + +EK+ LE E T+ + K++ + L+ T +QL
Sbjct: 2132 EKHLKEKKNMQ--EKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAA 2189
Query: 1259 ETEVLQTDHKNLKSLLNN-------------SKLEQTRL-EAEFSKLKEQYQQLDITSTK 1304
T+ + + + +++ SK E+ RL E S LK+Q +Q+ I +
Sbjct: 2190 FTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEE 2249
Query: 1305 LNNQCELLSQLKGNLEEENRHLLDQIQ-----TLMLQNRTLLEQNMESKDLFHVEQRQYI 1359
L L K + E Q+Q TL +N+ LL Q E++ L+H Q
Sbjct: 2250 LKINISRLEHDK-QIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQ---- 2304
Query: 1360 DKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTL 1419
NEL + + +L KS KD + SL
Sbjct: 2305 ---NELAKLESEL-------------------------------KSLKDQLTDLSNSLEK 2330
Query: 1420 TPTRSDSSEGFLQLPHQDSQDS 1441
+ + EG ++ D Q+S
Sbjct: 2331 CKEQKGNLEGIIRQQEADIQNS 2352
Score = 156 bits (395), Expect = 2e-37
Identities = 314/1570 (20%), Positives = 663/1570 (42%), Gaps = 284/1570 (18%)
Query: 83 VRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFI 142
+ +IK QE ++ ++ +L L + Q + E+++ +++ Q Q+KEEFI
Sbjct: 146 IEKIKHKLQE--KEELISTLQAQLTQAQAEQPAQSSTEMEEFVMM----KQQLQEKEEFI 199
Query: 143 ERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTD-----MSQEDIEPLLKNMALHL 197
+Q T+A AA Q+V ++ F+ Q D ++Q D+E ++ L
Sbjct: 200 STLQAQLSQTQAEQAA--QQVVREKDARFETQVRLHEDELLQLVTQADVETEMQQKLRVL 257
Query: 198 KRLIDERDEH---SETIIEL-------SEERDGL--HFLPHASSSAQSPCGSPGMKRTES 245
+R ++E +E +++L +E+R+ + L + + + +R ES
Sbjct: 258 QRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREES 317
Query: 246 R---QHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN------- 295
+ + + +E+A+ K L++E+ EQ Q ++E L+Q++
Sbjct: 318 KILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEK 377
Query: 296 -MNLLSDARSARMYRDELDALREK---------------AVRVDKLE-------SEVSRY 332
++LS ++ + + DAL+++ A + +LE E+S++
Sbjct: 378 TSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQF 437
Query: 333 KERL----HDI-------EFYKARVEELKEDNQVLLETKTM-LEDQLEGTRARSDKLHEL 380
RL H+ + Y + + E+N L+ + + LE++ S +L EL
Sbjct: 438 LNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEEL 497
Query: 381 EKENLQLKAKLHDMEMER---DMDRKKIEELMEENMTLEMAQKQ--SMDESLHLGWELEQ 435
+ EN +L +++ +E + + DR+ + E +++A K+ S +ES E
Sbjct: 498 KAENEKLSSQITLLEAQNRTGEADRE-----VSEISIVDIANKRSSSAEESGQDVLENTF 552
Query: 436 ISRTSELSE--APQKSLGHEVNELTSSRLLKLEMENQSLTKTVEEL--RTTVDSVEGNAS 491
+ ELS K E+ LKL+++ + + E+ + + +EG
Sbjct: 553 SQKHKELSVLLLEMKEAQEEI------AFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGI 606
Query: 492 KILKMEKENQRLSKKVEILENE------IVQEKQSLQNCQNLSKDLMKEKAQLEKTIETL 545
+KM+ + + ++ NE + +E+ S ++ S+++ A +E +++
Sbjct: 607 APIKMKVFLEDTGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVE--LKST 664
Query: 546 RENSERQIKIL-------EQENEHLNQTVSSL-------RQRSQISAEARVKDIEKENKI 591
+++ ++ + + + E E L + L ++ + + + + K+I N++
Sbjct: 665 KQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQL 724
Query: 592 LHESIK---ETSSKLSKIEFEKRQI---KKELEHYKEKGERAEELENELHHLEKE----- 640
+ E K SS + + E+ Q+ KEL E + ++LE L E++
Sbjct: 725 IEEFKKNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 784
Query: 641 ------NELLQKKITNLKITCE----KIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690
+ LL ++I +L I + KIE L+ E +++ + + + TL ++L QL+
Sbjct: 785 ESQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQLQFSE-QSTL--IRSLQSQLQ 841
Query: 691 SLEKENSQLDEENLELRRNVESLKCA-------SMKMAQLQLENK-ELESEKEQL-KKGL 741
+ E E + E + VE L A KM QL LE K ++E+ ++ + +K
Sbjct: 842 NKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQ 901
Query: 742 ELLKASFKKTER---LEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQK 798
++ + SF TE+ L L +E + L++ L ++ + + ++++ + L++
Sbjct: 902 QVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQ 961
Query: 799 NLEEL----KISSKRLEQ----LEKENKSLEQETSQLEKDKKQLEKENKRLRQQ-AEIKD 849
N +E+ +IS + L+ L+KEN+ +++ ++K+L + RL ++ A +KD
Sbjct: 962 NYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKD 1021
Query: 850 TTLEENNVKIGNLEKENKTLSKEIGIYKESCV--RLKELEKENKELVKRATIDIKTL-VT 906
+ +E + + E+ KE Y E CV + +E+E K+ + ++++ +
Sbjct: 1022 ESKKE--IPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKD 1079
Query: 907 LREDLVSE---KLKTQQMNNDLEKLTHEL---------------------------EKIG 936
L E L +E + +QMN L+ T+++ + +
Sbjct: 1080 LEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVA 1139
Query: 937 LNKERLL----------HDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEEST 986
L KE ++ H + +++ LE + E KK +E + + +A L+++
Sbjct: 1140 LVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQKK----LQEALTSRKAILKKAQ 1195
Query: 987 NYNQQLRQELKTVKKNYEALKQRQDEER-------------MVQSSPPISGE-DNKWERE 1032
+ LR+ELK K +Y L+++ DE+ +Q I G+ + ++E
Sbjct: 1196 EKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQE 1255
Query: 1033 SQETTRELLKVKDRLIEVERNNATLQA--------------------EKQALKTQLKQLE 1072
S +T L + + E L++ +K QLK++E
Sbjct: 1256 SCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIE 1315
Query: 1073 TQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK--LQVENSTLNSQSTSLMNQNAQLLIQ 1130
+ L+ ++ + + E+ LQ Q K L++E+ S + ++ Q ++
Sbjct: 1316 AEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLE 1375
Query: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGT-------- 1182
S L+ ++E + LI E+ Q SE E+ ++K T
Sbjct: 1376 SSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435
Query: 1183 LKSAHKNLEVEHRDLEDRYNQL------LKQKGQLEDLEKMLKVE-QEKMLLENKNHETV 1235
+K+ H LE++ ++ ++R QL +KQK + E K + Q K+ + +
Sbjct: 1436 IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEA 1495
Query: 1236 AAEYKKLCGENDRLNHTYSQLLK-----ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSK 1290
E K L E T +L K E++V +K ++L L L+ E K
Sbjct: 1496 LKENKSLQEELSLARGTIERLTKSLADVESQV-SAQNKEKDTVLGRLAL----LQEERDK 1550
Query: 1291 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTL----MLQNRTLLEQNME 1346
L + + + + L++ CE L L E+ L+ +I++L + ++ E++ E
Sbjct: 1551 LITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKE 1610
Query: 1347 SKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSK 1406
+ + + + Y + NE R + +E ++ + Y K+R +K
Sbjct: 1611 LQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYG-------------KLRSTEANK 1657
Query: 1407 KDINRERQKS 1416
K+ ++ Q++
Sbjct: 1658 KETEKQLQEA 1667
Score = 136 bits (342), Expect = 2e-31
Identities = 214/1031 (20%), Positives = 419/1031 (40%), Gaps = 198/1031 (19%)
Query: 159 HIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSE-E 217
H++E + + + EV + QE+++ + +A K + +D+ I E + E
Sbjct: 2154 HLEETIGEIQVTLNKKDKEVQQL-QENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWE 2212
Query: 218 RDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDC 277
R + + + + + + RQ +S+ + + K I RL E +Q+ +
Sbjct: 2213 RKFSDAIQSKEEEIRLKEDNCSVLKDQLRQ-MSIHMEELKINISRL-----EHDKQIWES 2266
Query: 278 KQELEQMEIELKR-----LQQENMNLLSDARSAR-MYRDELDALREKAVRVDKLESEVSR 331
K Q E++L++ LQ EN LLS R +Y + L KLESE+
Sbjct: 2267 KA---QTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELA-------KLESELKS 2316
Query: 332 YKERLHDIEFYKARVEELKEDNQVLLETKT-----------MLEDQLEGTRARSDKLHE- 379
K++L D+ + +E K + + ++ + LE L+ +R + +LHE
Sbjct: 2317 LKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEE 2376
Query: 380 -----------LEKENLQLKAKLHDMEMERDMDRKKIEELM----EENMTLEMAQKQSMD 424
L + ++ + ++ + D + K++E L+ EEN+ LE K+++D
Sbjct: 2377 INMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVD 2436
Query: 425 ESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSR----------------------- 461
++ L L+ I + + +A S ++ L + R
Sbjct: 2437 KTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Query: 462 -LLKLEMENQSLTKTVEELRTTVDSVEGNASKI-------------------------LK 495
+ + EN L + + LR+ +D + +K+ L+
Sbjct: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
Query: 496 ME-KENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSE---R 551
++ ++N+ L K LE ++ + +++ ++ + L +EK L K IE+L+ + R
Sbjct: 2557 VQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTR 2616
Query: 552 QIKILEQE------NEHLNQTVSSLRQRSQI--SAEARVKDIEKENKILHESIKETSSKL 603
Q+ L++E + L + + S + S++ R+ ++E+E + KE + K+
Sbjct: 2617 QVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQ---KEAAKKV 2673
Query: 604 SKIEFEKRQIKKELEHY-------KEKGERAEE-----------LENELHHLEKENELLQ 645
+IE ++KKEL+H + + E AEE +E +L + KEN+ L
Sbjct: 2674 GEIE---DKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKGLT 2730
Query: 646 KKITNLKITCEKIE-ALEQENSELERENRKLKKTLDSFKNLTFQ---------------- 688
+I + + ++ + + N EL+ RK +L L Q
Sbjct: 2731 AQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAF 2790
Query: 689 ---------LESLEKENSQL---DEENLELRRNVES----LKCASMKMAQLQLENKELES 732
L LEK N QL DE+ L L +E ++ S MA LQ E L +
Sbjct: 2791 SMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWN 2850
Query: 733 EKEQLKKGLELLKASFKK-------TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
E E+ +K E + S + + L+ + L + RL K L+N ++ Q+ E
Sbjct: 2851 ELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQE 2910
Query: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
+ +L LQ+ ++ K E+L +EN S + E QL +K E +R+++Q
Sbjct: 2911 ITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQY 2970
Query: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKE-----NKELVKRATID 900
+ + ++ + NL +E ++ S + K R E ++ LV +
Sbjct: 2971 LMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELL 3030
Query: 901 IKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGL----NKERLLHDEQSTDD---RY 953
L +++ ++L+ QQ+N++ +L E + + + L ++Q D
Sbjct: 3031 RTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHC 3090
Query: 954 KLLESKLESTLKKSLEIKEEKIAALE----------ARLEESTNYNQQLRQELKTVKKNY 1003
+LE +++ L I A E L E + +Q+L ++
Sbjct: 3091 AVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEV 3150
Query: 1004 EALKQRQDEER 1014
L++ +EER
Sbjct: 3151 NELRKLLEEER 3161
Score = 103 bits (257), Expect = 2e-21
Identities = 218/1101 (19%), Positives = 434/1101 (39%), Gaps = 152/1101 (13%)
Query: 510 LENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQ---T 566
L+ E+ QE N +D+ + A E+ + L++ ++ L+Q++E L +
Sbjct: 30 LDPELHQESDMEFN-NTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQEERKA 88
Query: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGER 626
+ ++ ++ A+A++ + NK + E + + L + Q+ K H K E
Sbjct: 89 ADNKIKKLKLHAKAKLTSL---NKYIEEMKAQGGTVLPTEPQSEEQLSK---HDKSSTEE 142
Query: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELER---ENRKLKKTLDSFK 683
E+E H L+++ EL+ ++T + E Q ++E+E ++L++ +
Sbjct: 143 EMEIEKIKHKLQEKEELI--STLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFIS 200
Query: 684 NLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLEL 743
L QL + E + + R ++ ++ QL + ++E+E +Q + L+
Sbjct: 201 TLQAQLSQTQAEQAAQQVVREKDARFETQVRLHEDELLQL-VTQADVETEMQQKLRVLQ- 258
Query: 744 LKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLE-- 801
+K E E S G LQ+ L + ++ Q L +LQ +E E+ TL+ +E
Sbjct: 259 -----RKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETE 313
Query: 802 -----------ELKISSKRL--EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIK 848
EL+++ ++L L++E L ++ Q + + +LE L Q+ + +
Sbjct: 314 REESKILLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAE 373
Query: 849 DTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLR 908
+EE I +L+K + L K+ +L L+ +N++ V+ A +T+ L
Sbjct: 374 ---MEEKTSHILSLQKTGQELQSACDALKDQNSKL--LQDKNEQAVQSA----QTIQQLE 424
Query: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL 968
+ L + + Q N L HE + + + + E + S K+ +
Sbjct: 425 DQLQQKSKEISQFLNRLPLQQHE------TASQTSFPDVYNEGTQAVTEENIASLQKRVV 478
Query: 969 EIKEEKIAAL--EARLEESTNYNQQLRQELKTVK-KNYEALKQRQDEERMV-------QS 1018
E++ EK A L LEE N++L ++ ++ +N R+ E + S
Sbjct: 479 ELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSS 538
Query: 1019 SPPISGED---NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQN 1075
S SG+D N + ++ +E + LL++K+ E+ LQ ++ + +
Sbjct: 539 SAEESGQDVLENTFSQKHKELSVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEM 598
Query: 1076 NNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLE 1135
++ + +A + V L++ N +S+ + Q + S
Sbjct: 599 KQMEGEGIAPIKMKVFLEDTGQDFPLMP----------NEESSLPAVEKEQASTEHQSRT 648
Query: 1136 NENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLK-SAHKNLEVEH 1194
+E S+ +LKS K + + + E E L S+ L+ + HK E+
Sbjct: 649 SEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYE 708
Query: 1195 RDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYS 1254
++L+++ ++ +E+ + KN + ++ + L E D+L
Sbjct: 709 KNLDEKAKEISNLNQLIEEFK--------------KNADNNSSAFTALSEERDQLLSQVK 754
Query: 1255 QLLKETEV---LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCEL 1311
+L TE+ ++ NL +L+ A + L EQ L I + + + E+
Sbjct: 755 ELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKSKDVKIEV 814
Query: 1312 LSQLKGNLEEENRHLLDQIQTLMLQNRTLLE------QNMESKDLFHVEQRQYI----DK 1361
L ++ LD +Q + TL+ QN ES+ L E+ ++I ++
Sbjct: 815 L-----------QNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEE 863
Query: 1362 LNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTP 1421
L++ QKE LE MDQ L++ K+D+ TL
Sbjct: 864 LSQALSQKE-LEITKMDQL---------------------LLEKKRDVE-------TLQQ 894
Query: 1422 TRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKM 1481
T + + ++ ++ + G + T K + L R + ++D
Sbjct: 895 TIEEKDQQVTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQVEEDN- 953
Query: 1482 KACYRRSMSMNDLVQSMVLAGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTV 1541
S + M AGQ S E L+ D+ K+ E IN +
Sbjct: 954 ----EVSSGLKQNYDEMSPAGQI--SKEELQHEFDLL--KKENEQRKRKLQAALINRKEL 1005
Query: 1542 NSSAGFRSKQLVNNKDTTSFE 1562
++L N KD + E
Sbjct: 1006 LQRVSRLEEELANLKDESKKE 1026
Score = 70.5 bits (171), Expect = 1e-11
Identities = 98/467 (20%), Positives = 199/467 (42%), Gaps = 72/467 (15%)
Query: 919 QQMNNDLEKLTHELEKIGLN-------KERLLHDEQSTDDRYKLLESKLESTLKKSLEIK 971
Q M L+ H+ + N +ERL + EQ + ++ K +K ++
Sbjct: 24 QNMRAPLDPELHQESDMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEALQ 83
Query: 972 EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWER 1031
EE+ AA ++ +L + K N + + ++ + P + +K ++
Sbjct: 84 EERKAA------DNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDK 137
Query: 1032 ESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS 1091
S E E+ K+K +L E E +TLQA Q + Q +Q Q++ + + +++Q
Sbjct: 138 SSTEEEMEIEKIKHKLQEKEELISTLQA--QLTQAQAEQ-PAQSSTEMEEFVMMKQQLQE 194
Query: 1092 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1151
+E +TLQ Q + Q+ E + V++E++ +
Sbjct: 195 KEEFISTLQAQ--------------------------LSQTQAEQAAQQVVREKD---AR 225
Query: 1152 YDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL 1211
+++ ++ HE E L+++ + L V R LE+ + + L + Q+
Sbjct: 226 FETQVRLHE----------DELLQLVTQADVETEMQQKLRVLQRKLEE-HEESLVGRAQV 274
Query: 1212 EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLK 1271
DL ++QE E +N + ++ + +++ E++ L +T +E+++L + ++
Sbjct: 275 VDL-----LQQELTAAEQRN-QILSQQLQQMEAEHNTLRNTVETEREESKILL---EKME 325
Query: 1272 SLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL-KGNLEEENRHLLDQI 1330
+ KL L+ E L EQ++Q +L ++ L Q K +EE+ H+L
Sbjct: 326 LEVAERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQ 385
Query: 1331 QT---LMLQNRTLLEQN---MESKDLFHVEQRQYIDKLNELRRQKEK 1371
+T L L +QN ++ K+ V+ Q I +L + +QK K
Sbjct: 386 KTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSK 432
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 187 bits (475), Expect = 8e-47
Identities = 250/1122 (22%), Positives = 487/1122 (43%), Gaps = 127/1122 (11%)
Query: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE-QMEIELKRL-------- 291
K S + L +A K R+ELEEK LL K +L+ Q++ E L
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCD 906
Query: 292 QQENMNLLSDARSARM---YRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE 348
Q + +A+ M DE + E + KLE E S K + D+E A+VE+
Sbjct: 907 QLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEK 966
Query: 349 LKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAK----LHDMEMERDMDRKK 404
K T+ +++ E + + +L KE L+ L D++ E D K
Sbjct: 967 EKH------ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED----K 1016
Query: 405 IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLK 464
+ L + + LE Q +D+ L LEQ + E ++ L ++ +LT ++
Sbjct: 1017 VNTLTKAKVKLE----QQVDD---LEGSLEQEKKVRMDLERAKRKLEGDL-KLTQESIMD 1068
Query: 465 LEMENQSLTKTVE----ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520
LE + Q L + ++ EL +E + +++K+ + L ++E LE E+ E+ +
Sbjct: 1069 LENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTA 1128
Query: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
+ L DL +E ++ + +E + QI++ ++ + L + + + EA
Sbjct: 1129 RAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEAT-LQHEA 1187
Query: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
+ K++ +S+ E ++ ++ ++K++LE KEK E EL++ ++E+
Sbjct: 1188 TAAALRKKHA---DSVAELGEQIDNLQ----RVKQKLE--KEKSEFKLELDDVTSNMEQ- 1237
Query: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLD 700
+ K NL+ C +E ++ K ++T S +LT Q L+ EN +L
Sbjct: 1238 ---IIKAKANLEKMCRTLE------DQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELS 1288
Query: 701 EENLELRRNVESLKCASMKMAQLQLEN--KELESEKEQLKKGLELLKASFKKTERLEVSY 758
+ E + L + Q QLE+ ++LE E + L+++ + L Y
Sbjct: 1289 RQLDEKEALISQLTRGKLTYTQ-QLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQY 1347
Query: 759 QGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKEN 817
+ LQ+ L +N ++ Q ++ + ++ + LEE K ++RL++ E+
Sbjct: 1348 EEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRT---EELEEAKKKLAQRLQEAEEAV 1404
Query: 818 KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL---------------------EENN 856
+++ + S LEK K +L+ E + L E + EE+
Sbjct: 1405 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQ 1464
Query: 857 VKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLV 912
++ + +KE ++LS E+ Y+ES L+ ++ENK L + + DL
Sbjct: 1465 SELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEIS-----------DLT 1513
Query: 913 SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQST--DDRYKLLESKLESTLKKSLEI 970
+ + + ++LEK+ +LE + + L + +++ + K+L ++LE K+ EI
Sbjct: 1514 EQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKA-EI 1572
Query: 971 KEEKIAALEARLEESTNYNQQLRQELKT-----VKKNYEALKQRQDEERMVQSSPPISGE 1025
E K+A + +E++ + ++ L+T + EAL+ ++ E +
Sbjct: 1573 -ERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSH 1631
Query: 1026 DNKWERESQETTRELLKV-KDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILA 1084
N+ E+Q+ + L + KD I+++ ++A LK + +E +NN LQA++
Sbjct: 1632 ANRMAAEAQKQVKSLQSLLKDTQIQLDD---AVRANDD-LKENIAIVERRNNLLQAELEE 1687
Query: 1085 LQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKE 1144
L+ + + + + L+SQ+TSL+NQ ++ S L+ E E ++E
Sbjct: 1688 LRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQE 1747
Query: 1145 REDLKSLYDSLIKDHEKL--ELLHERQASEYESLISKH--GTLKSAHKNL-EVEHRDLED 1199
+ + I D + EL E+ S + + K+ T+K L E E L+
Sbjct: 1748 CRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQHRLDEAEQIALKG 1807
Query: 1200 RYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLC--GENDRLNHTYSQLL 1257
QL K + ++ +LE L+ EQ++ K K+L E DR N LL
Sbjct: 1808 GKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKN-----LL 1862
Query: 1258 KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLD 1299
+ +++ +K+ ++ + + SK ++ +LD
Sbjct: 1863 RLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELD 1904
Score = 151 bits (382), Expect = 5e-36
Identities = 216/979 (22%), Positives = 431/979 (44%), Gaps = 144/979 (14%)
Query: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
KI + K +R K++ ++ E + K++L+ + K+L EK + L+E ++
Sbjct: 835 KIKPLLKSAER-EKEMASMKEEFTRLKEALEKSEARRKELE------EKMVSLLQEKNDL 887
Query: 552 QIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFE 609
Q+++ + E ++L Q +++I EA+VK++ + + E E ++K K+E E
Sbjct: 888 QLQV-QAEQDNLADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDE 946
Query: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNL------------KITCEK 657
++K++++ +LE L +EKE + K+ NL K+T EK
Sbjct: 947 CSELKRDID----------DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEK 996
Query: 658 I---EALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK 714
EA +Q +L+ E K+ + L Q++ LE Q + ++L R L+
Sbjct: 997 KALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLE 1056
Query: 715 CASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLEN 774
+K+ Q + +LE++K+QL E LK + L + +LQK L+
Sbjct: 1057 -GDLKLTQESI--MDLENDKQQLD---ERLKKKDFELNALNARIEDEQALGSQLQKKLKE 1110
Query: 775 SNKKIQQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSLEQETS-QLEKDKK 832
+I++LE EL+ +T + +E+L+ S+ LE++ + + TS Q+E +KK
Sbjct: 1111 LQARIEELEEELE----AERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKK 1166
Query: 833 QLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE-LEKENK 891
+ E E +++R+ ++++ TL+ + L K++ E+G ++ R+K+ LEKE
Sbjct: 1167 R-EAEFQKMRR--DLEEATLQ-HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKS 1222
Query: 892 ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDD 951
E +++ + + E ++ K ++M LE +E +R ++D T
Sbjct: 1223 EF----KLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSKAEETQRSVND--LTSQ 1276
Query: 952 RYKLLESKLESTLKKSLEIKE--------------EKIAALEARLEESTNYNQQLRQELK 997
R KL E L + L+ KE +++ L+ +LEE L L+
Sbjct: 1277 RAKLQTENGE--LSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQ 1334
Query: 998 TVKKNYEALKQRQDEER---------MVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048
+ + + + L+++ +EE + +++ ++ K+E ++ + T EL + K +L
Sbjct: 1335 SARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLA 1394
Query: 1049 E--------VERNNA---TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL----- 1092
+ VE NA +L+ K L+ +++ L A AL ++ +
Sbjct: 1395 QRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILA 1454
Query: 1093 --QEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKS 1150
+++ Q++ Q E +L+++ L N + L + + EN+++ +E DL
Sbjct: 1455 EWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDLTE 1514
Query: 1151 LYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDL---EDRYNQLLKQ 1207
S K +LE + ++ +E L S L+ A +LE E + + +NQ+ +
Sbjct: 1515 QLGSSGKTIHELEKVRKQLEAEKMELQS---ALEEAEASLEHEEGKILRAQLEFNQIKAE 1571
Query: 1208 KGQLEDLEKMLKVEQEKMLLENKNHETVAAEY------------------KKLCGENDRL 1249
+E+ L + E+M +NH V KK+ G+ + +
Sbjct: 1572 ------IERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEGDLNEM 1625
Query: 1250 NHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQC 1309
S + Q K+L+SLL +++++ LKE ++ + L +
Sbjct: 1626 EIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAE- 1684
Query: 1310 ELLSQLKGNLE--EENRHLLDQ--------IQTLMLQNRTLLEQNMESKDLFHVEQRQYI 1359
L +L+ +E E +R L +Q +Q L QN +L+ Q + Q +
Sbjct: 1685 --LEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVE 1742
Query: 1360 DKLNELRRQKEKLEEKIMD 1378
+ + E R +EK ++ I D
Sbjct: 1743 EAVQECRNAEEKAKKAITD 1761
Score = 124 bits (312), Expect = 7e-28
Identities = 169/787 (21%), Positives = 323/787 (41%), Gaps = 72/787 (9%)
Query: 605 KIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQE 664
K+ F+ + + K E KE EE LEK +E +K++ EK+ +L QE
Sbjct: 831 KLYFKIKPLLKSAEREKEMASMKEEFTRLKEALEK-SEARRKELE------EKMVSLLQE 883
Query: 665 NSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQ 724
++L+ + ++ D+ + + + L K QL+ + E+ E L+ A+L
Sbjct: 884 KNDLQLQ---VQAEQDNLADAEERCDQLIKNKIQLEAKVKEMN---ERLEDEEEMNAELT 937
Query: 725 LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLES 784
+ ++LE E +LK+ ++ L+ + K E+ E + ++N +++ L+
Sbjct: 938 AKKRKLEDECSELKRDIDDLELTLAKVEK----------EKHATENKVKNLTEEMAGLDE 987
Query: 785 ELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQ 844
+ L E + LQ + + L+ L+ E E + + L K K +LE QQ
Sbjct: 988 IIAKLTKEKKALQ------EAHQQALDDLQAE----EDKVNTLTKAKVKLE-------QQ 1030
Query: 845 AEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
+ + +LE+ +LE+ + L ++ + +ES + L+ +++ E +K+ ++ L
Sbjct: 1031 VDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNAL 1090
Query: 905 VTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTL 964
ED E+ Q+ L++L +E++ E L E++ + + L S L L
Sbjct: 1091 NARIED---EQALGSQLQKKLKELQARIEEL----EEELEAERTARAKVEKLRSDLSREL 1143
Query: 965 KKSLEIKEEKIAALEARLEESTNYN---QQLRQELKTVKKNYEALKQRQDEERMVQSSPP 1021
++ E EE A ++E + Q++R++L+ +EA ++ S
Sbjct: 1144 EEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAAL-RKKHADSVAE 1202
Query: 1022 ISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQ 1081
+ + + +R Q+ +E + K L +V N + K L+ + LE Q N +++
Sbjct: 1203 LGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQMNEHRSK 1262
Query: 1082 ILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1141
QR L Q LQT+N +L + + + L Q L+ + E
Sbjct: 1263 AEETQRSVNDLTSQRAKLQTENGELSRQLDEKEALISQLTRGKLTYTQQLEDLKRQLEEE 1322
Query: 1142 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRY 1201
+K + L S D +LL E+ E E+ L A+ + E
Sbjct: 1323 VKAKNALAHALQSARHD---CDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDA 1379
Query: 1202 NQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETE 1261
Q + E+LE+ K +++ + E V A+ L RL + L+ + E
Sbjct: 1380 IQ------RTEELEEAKKKLAQRLQEAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1433
Query: 1262 -------VLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1314
L +N +L K + ++E +++ + L KL N E +
Sbjct: 1434 RSNAAAAALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLE 1493
Query: 1315 LKGNLEEENRHLLDQIQTLMLQ----NRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKE 1370
+ EN++L ++I L Q +T+ E K L E+ + L E E
Sbjct: 1494 HLETFKRENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL-EAEKMELQSALEEAEASLE 1552
Query: 1371 KLEEKIM 1377
E KI+
Sbjct: 1553 HEEGKIL 1559
Score = 121 bits (303), Expect = 7e-27
Identities = 151/679 (22%), Positives = 300/679 (44%), Gaps = 67/679 (9%)
Query: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
KE+ S KE+ + E L+ S + + LE L E LQ ++Q + L
Sbjct: 847 KEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQL-------QVQAEQDNLA 899
Query: 788 DLEMENQTLQKNLEELKISSKRL-EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
D E L KN +L+ K + E+LE E E+ ++L K++LE E L++ +
Sbjct: 900 DAEERCDQLIKNKIQLEAKVKEMNERLEDE----EEMNAELTAKKRKLEDECSELKRDID 955
Query: 847 IKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVT 906
+ TL + + E + K L++E+ E +L + +K +E ++A D++
Sbjct: 956 DLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEED 1015
Query: 907 LREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKER----LLHDEQSTDDRYKLLESKLES 962
L K+K +Q +DLE + +K+ ++ ER L D + T + LE+ +
Sbjct: 1016 KVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLEND-KQ 1074
Query: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1022
L + L+ K+ ++ AL AR+E+ QL+++LK ++ E L++ + ER ++
Sbjct: 1075 QLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARA---- 1130
Query: 1023 SGEDNKWERESQETTRELLKVKDRL--------IEVERNNATLQAEKQALKTQLKQLETQ 1074
K E+ + +REL ++ +RL +++E N +AE Q ++ L++ Q
Sbjct: 1131 -----KVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKR-EAEFQKMRRDLEEATLQ 1184
Query: 1075 NNNLQAQILALQRQTVS-LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSS 1133
+ A + +V+ L EQ LQ KL+ E S + + + Q++ +++
Sbjct: 1185 HEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKAN 1244
Query: 1134 LENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE 1193
LE + ++L D + + K E E Q S L S+ L++ + L +
Sbjct: 1245 LE----------KMCRTLEDQMNEHRSKAE---ETQRS-VNDLTSQRAKLQTENGELSRQ 1290
Query: 1194 HRDLEDRYNQLLKQK----GQLEDLEKMLKVEQEKM-----LLENKNH--ETVAAEYKKL 1242
+ E +QL + K QLEDL++ L+ E + L++ H + + +Y++
Sbjct: 1291 LDEKEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEE 1350
Query: 1243 CGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1302
L S+ E +T ++ ++ +LE+ + KL ++ Q+ +
Sbjct: 1351 TEAKAELQRVLSKANSEVAQWRTKYET-DAIQRTEELEEAK-----KKLAQRLQEAEEAV 1404
Query: 1303 TKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1362
+N +C L + K L+ E L+ ++ L ++ + +++Y +
Sbjct: 1405 EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYEESQ 1464
Query: 1363 NELRRQKEKLEEKIMDQYK 1381
+EL +++ + +K
Sbjct: 1465 SELESSQKEARSLSTELFK 1483
Score = 70.9 bits (172), Expect = 1e-11
Identities = 103/525 (19%), Positives = 211/525 (40%), Gaps = 73/525 (13%)
Query: 940 ERLLHDEQSTDDRYKLLESKL---ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 996
E+LL ++YK +K+ L E+++E+++ + R++ Q R L
Sbjct: 743 EKLLSSLDIDHNQYKFGHTKVFFKAGLLGLLEEMRDERLSRIITRIQA------QSRGVL 796
Query: 997 KTVKKNYEALKQRQDEERMVQ-SSPPISGEDN-KWER---------ESQETTRELLKVKD 1045
+ Y+ L +R+D ++Q + G N W + +S E +E+ +K+
Sbjct: 797 --ARMEYKKLLERRDSLLVIQWNIRAFMGVKNWPWMKLYFKIKPLLKSAEREKEMASMKE 854
Query: 1046 RLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK 1105
++ +A ++ L+ ++ L + N+LQ Q+ A Q +E+ L +
Sbjct: 855 EFTRLKEALEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLADAEERCDQLIKNKIQ 914
Query: 1106 LQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK---------------- 1149
L+ + +N + NA+L ++ LE+E + ++ +DL+
Sbjct: 915 LEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDLELTLAKVEKEKHATENK 974
Query: 1150 ------------SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDL 1197
+ L K+ + L+ H++ + ++ K TL A LE + DL
Sbjct: 975 VKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQQVDDL 1034
Query: 1198 EDRYNQLLKQKGQLE----DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTY 1253
E Q K + LE LE LK+ QE ++ + + + KK E + LN
Sbjct: 1035 EGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNALNARI 1094
Query: 1254 -------SQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLN 1306
SQL K+ + LQ + L+ L + + ++E S L + +++ +
Sbjct: 1095 EDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAG 1154
Query: 1307 NQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELR 1366
+ ++ E E + + ++ LQ+ + E + ID L ++
Sbjct: 1155 GATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVK 1214
Query: 1367 RQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINR 1411
++ EK EK + + D +T M ++IK+K ++ +
Sbjct: 1215 QKLEK--EKSEFKLELDD----------VTSNMEQIIKAKANLEK 1247
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 186 bits (472), Expect = 2e-46
Identities = 275/1367 (20%), Positives = 578/1367 (42%), Gaps = 227/1367 (16%)
Query: 196 HLKRLIDERDEHSETIIELSEERDGL-HFLPHASSSAQSPCGSPGMKRTESRQHLSVELA 254
H ++L + H E + + E + L + L S S + ++ Q L +E
Sbjct: 243 HQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKV 302
Query: 255 DAKAKIRRLRQELEEKTEQLLDC-------KQELEQMEIELKRLQQENMNL---LSDARS 304
++ K+ +L ++++ ++L ++E EQ+ +E +++ +E NL S +
Sbjct: 303 ESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQP 362
Query: 305 ARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDN----------- 353
+ + + + +E+ + EV R ++ L D E R+ L +DN
Sbjct: 363 SAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKM 422
Query: 354 --QVLLETKTMLEDQLEGTRARSDKL---HELEKE----NLQLKAKLHDMEMERDMDRKK 404
+VL + K++L + E + KL +E+ K ++ L ++LHD+ + + ++
Sbjct: 423 RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQE 482
Query: 405 IEELMEENMTL----EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
+ + + E TL E +Q+ + + H+ +Q+S+ ++ L ++N+
Sbjct: 483 LNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLND-EKK 541
Query: 461 RLLKLEMENQSLTKTVEELRTTV------------------DSVEGNASKILKMEKENQR 502
R+ +LE + +TK ++ + + D VE ++ K ++ N
Sbjct: 542 RVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVS 601
Query: 503 LSKKVEILENEIVQEKQSLQNCQN-LSKDLMKEK-AQLEKTIETLRENSERQIKILEQEN 560
+ K+ L+ I Q ++ L +N L + L ++ + + T+ RE R +K E
Sbjct: 602 IQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
Query: 561 EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIK-------ETSSKLSKIEFEKRQI 613
E LN+ + + ++ E V E L E + E ++ + ++ EK +I
Sbjct: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
Query: 614 KKEL--------EHYKEKGERAEELEN-----------ELHHLEKENELLQKKITNLKIT 654
+ EL E + + EEL N E HL K N+ +I LK
Sbjct: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781
Query: 655 CEKIEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQLDEE----NLELRRN 709
E+++ +E ++ + + +K L N +E L++ +S+L EE + LR+N
Sbjct: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKN 841
Query: 710 V---ESLKCASMKMAQLQLENKELESEKEQLK------------KGLELLKASFKKTERL 754
++++ + ++ EN L+ E E+L+ K L+ + + +L
Sbjct: 842 EILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQL 901
Query: 755 EVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL---- 810
+ L+ E + QK +E+ N+ QL LQ+ + E + E++ + +L
Sbjct: 902 NTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEK 961
Query: 811 -EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTL 869
E+++ K++EQ +QL ++++ ++ +N + Q+ +++ +E + K + E + L
Sbjct: 962 DEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERL 1021
Query: 870 SKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLT 929
K I KE + +K L ++N L K+ ID Q +++ KLT
Sbjct: 1022 VKGI---KERELEIKLLNEKNISLTKQ--ID------------------QLSKDEVGKLT 1058
Query: 930 HELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN 989
+++ L + L ST ++ L+ L+ +E+ A L + E+++
Sbjct: 1059 QIIQQKDLEIQALHARISSTSHTQDVVY--LQQQLQAYAMEREKVFAVLNEKTRENSHLK 1116
Query: 990 QQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKD---- 1045
+ + + V AL + QDE + + + SG+D RE+ + +++ KD
Sbjct: 1117 TEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQD--MFRETIQNLSRIIREKDIEID 1174
Query: 1046 -------RLIEVERNNAT--------------LQAEKQALKTQLKQLETQNNNLQAQILA 1084
L+ V + ++T L E+ LK Q+K++E + +
Sbjct: 1175 ALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQN 1234
Query: 1085 LQRQTVSLQEQNTTLQTQ-------NAKLQVENSTL----NSQSTSLMNQNAQLLIQQSS 1133
+Q ++ LQE+ LQ Q N+KLQV+ + L T L N +L Q S
Sbjct: 1235 MQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHS 1294
Query: 1134 ---------------------LENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1172
L + + + E L++ ++ E ELL +
Sbjct: 1295 IGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLS--ESSELLQQELEEL 1352
Query: 1173 YESLISKHGTLKSAHKN-----------LEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVE 1221
+SL K T+++ +N E+E ++ E +++ + K + + L+K+LK
Sbjct: 1353 RKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLK-- 1410
Query: 1222 QEKMLLENKNHETVAA--EYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKL 1279
++ +L++ K+ + +++ + EN+ L + L + +L+ D LK N K+
Sbjct: 1411 EKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKG--ENEKI 1468
Query: 1280 EQT--RLEAEFSKLKEQYQQLDITSTKLNNQC-----------ELLSQLKGNLEEENRHL 1326
+T E E+ L+E + + + +C +LL + + E L
Sbjct: 1469 VETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQL 1528
Query: 1327 LDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL--NELRRQKEK 1371
L+ +++ +Q +T++ Q + + ++Q+Q + NE++R ++K
Sbjct: 1529 LNAVKS--MQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK 1573
Score = 159 bits (403), Expect = 2e-38
Identities = 289/1382 (20%), Positives = 570/1382 (41%), Gaps = 229/1382 (16%)
Query: 155 AVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL 214
A +A ++EV Q+ + D + E+ +S + + L L LK I+ ++ L
Sbjct: 379 AQSASVEEVFRLQQALSDAE-NEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL---L 434
Query: 215 SEERDGLHFLPHASSSAQSPCGSPGMKRTESRQ-HLSVELADAKAKIRRLRQELEEKTEQ 273
S+E++ L ++ +K T +R L EL D LR LE K ++
Sbjct: 435 SQEKEELQMSLLKLNNEYEV-----IKSTATRDISLDSELHD-------LRLNLEAKEQE 482
Query: 274 LLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-DKLESEVSRY 332
L E E + E++ L ++N + + +D+L + + + KL+ +++
Sbjct: 483 LNQSISEKETLIAEIEELDRQNQEA---TKHMILIKDQLSKQQNEGDSIISKLKQDLNDE 539
Query: 333 KERLHDIEFYKARV-EELKEDNQVLLE----------TKTMLEDQLEGTRARSDKLHE-- 379
K+R+H +E K + +EL + L++ TK LED++E + +K E
Sbjct: 540 KKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESN 599
Query: 380 --LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS 437
++KENL+LK + E E R ELM+ +L + ++L E E +
Sbjct: 600 VSIQKENLELKEHIRQNEEELSRIRN---ELMQ---SLNQDSNSNFKDTLLKEREAEVRN 653
Query: 438 RTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVD---------SVEG 488
LSE Q +NE ++MEN+ L E++R ++ S+E
Sbjct: 654 LKQNLSELEQ------LNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEK 707
Query: 489 NAS-KILKMEK---ENQRLSKKVEILENEIVQEK--QSLQNCQNLSKDLMK--------- 533
N + LKMEK E + K +LE EK + L N +NL+ ++
Sbjct: 708 NTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKL 767
Query: 534 ------EKAQLEKTIETLRENSERQIKILE---QENEHLNQTVSS-------LRQRSQIS 577
E A+L+K IE + + + +L +E + L Q ++ L++RS
Sbjct: 768 NQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKL 827
Query: 578 AEARVKDIE--KENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAE------- 628
E K + ++N+IL ++I+E L ++ E +++ELE +E+ R
Sbjct: 828 QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKT 887
Query: 629 -----ELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFK 683
EL +E+ L E L+++I + + + IE Q +L + ++ KK +D F+
Sbjct: 888 LDSVTELASEVSQLNTIKEHLEEEIKHHQ---KIIEDQNQSKMQLLQSLQEQKKEMDEFR 944
Query: 684 NLTFQLESLEKENSQL----DEENLELRRNVESLKCASMKMAQ-LQLENKELESEKE--- 735
+Q E + ++QL DEE L++ +E +K + Q +Q +N ++ E +
Sbjct: 945 ---YQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQS 1001
Query: 736 -QLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE--------L 786
++ G E S +TERL + ++E + L + + K+I QL + +
Sbjct: 1002 LNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQII 1061
Query: 787 QDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE 846
Q ++E Q L + ++ + L+++ ++ E ++ + +EN L+ +
Sbjct: 1062 QQKDLEIQALHARISSTS-HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH 1120
Query: 847 IKDTTLEENNVKIGNLEKENKTLSKEI-----GIYKESCVRLKELEKENKELVKRATIDI 901
+ + L+ ENK LS +++E+ L + +E + +
Sbjct: 1121 KMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 1180
Query: 902 KTLVTLR-----------------EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944
+TL+ + E+L+ E+ K +Q ++K+ +++ + + H
Sbjct: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQ---VKKMEEWKQQVMTTVQNMQH 1237
Query: 945 DEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEEST---NYNQQLRQ------- 994
+ + L++++ + +++ + +++ + T N+ Q+L Q
Sbjct: 1238 ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
Query: 995 ------------ELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLK 1042
++ + + + +L Q E + S + E ++ ++ E R+ L+
Sbjct: 1298 LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ 1357
Query: 1043 VKDRLIE-VERNNATL-----------QAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1090
KD I ++ NN L + E + +++KQL+ + + LQ ++L + +
Sbjct: 1358 EKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQ-KLLKEKDLLI 1416
Query: 1091 SLQEQNTTLQTQNAKLQV-ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLK 1149
+ +N +V EN L T+L + L + L+ ENE +++ +
Sbjct: 1417 KAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKE 1476
Query: 1150 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK- 1208
+ Y +L + + K ++ + E S+ ++ + QLLK+K
Sbjct: 1477 TEYQALQETNMKFSMMLREKEFECHSM------------------KEKALAFEQLLKEKE 1518
Query: 1209 ----GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ 1264
G+L L +K QEK ++ + + V K+ EN L + EV +
Sbjct: 1519 QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTAL---------QNEVQR 1569
Query: 1265 TDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ----LKGNLE 1320
K +S +L LE+E S +E D KL + +L + +E
Sbjct: 1570 LRDKEFRSNQELERLRNHLLESEDSYTREALAAED-REAKLRKKVTVLEEKLVSSSNAME 1628
Query: 1321 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQ---RQYIDKLNELRRQKE--KLEEK 1375
+ Q+++L Q + +Q E+ V Q +QY L L+ E + EEK
Sbjct: 1629 NASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEK 1688
Query: 1376 IM 1377
M
Sbjct: 1689 AM 1690
Score = 154 bits (390), Expect = 6e-37
Identities = 262/1233 (21%), Positives = 516/1233 (41%), Gaps = 199/1233 (16%)
Query: 355 VLLETKTMLEDQLEGTRARS-DKLHE-LEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
+L+E +E +L +R + + +H L EN +LK D+E + + +I++ ++
Sbjct: 37 MLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQ---QS 93
Query: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
+ +Q E HL + QI+ +L + L + S + + S
Sbjct: 94 TSYRNQLQQKEVEISHL--KARQIALQDQLLK-----LQSAAQSVPSGAGVPATTASSSF 146
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQ--NCQNLSKD 530
+ + + + I+ ++E RLS +V LE+E+ + Q Q
Sbjct: 147 AYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNS 206
Query: 531 LMKEKAQLEKTIETLRENSERQIKILEQE-----NEHLNQ-TVSSLRQRSQIS-AEARVK 583
E +L+ I+ L++N ++I + E N H + T S R R ++S E R++
Sbjct: 207 DQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIE 266
Query: 584 DIEK----------ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEK----GERAEE 629
++E E + I E + ++ EK + K++E ++K ++
Sbjct: 267 ELENLLQQGGSGVIETDL--SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSS 324
Query: 630 LENELHHLEKENELL-------QKKITNLKITCEKIE--ALEQENSELEREN-------- 672
EN+ L +E E L ++ NLK+ C K++ A++Q ++ E+E
Sbjct: 325 AENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASV 384
Query: 673 ---RKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
+L++ L +N +L SL ++NS L E+NL+L+ +E L+ ++Q E +E
Sbjct: 385 EEVFRLQQALSDAENEIMRLSSLNQDNS-LAEDNLKLKMRIEVLEKEKSLLSQ---EKEE 440
Query: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
L+ +L E++K++ + L+ L + + ++ L S + + L +E+++L
Sbjct: 441 LQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEEL 500
Query: 790 EMENQTLQKNLEELKISSKR--------LEQLEKENKSLEQETSQLEKDKKQLEKE---- 837
+ +NQ K++ +K + + +L+++ ++ QLE DK + KE
Sbjct: 501 DRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQ 560
Query: 838 -NKRLRQQAEIKDTTLEENNV--KIGNL-EKENKTLSKEIGIYKESCVRLKELEKENKEL 893
K ++ + + D L + + K+ NL ++ NK+ + I KE+ + LKE ++N+E
Sbjct: 561 KEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKEN-LELKEHIRQNEEE 619
Query: 894 VKRATIDI-------------KTLVTLRE----DLVSEKLKTQQMNNDLEKLT------- 929
+ R ++ TL+ RE +L + +Q+N +L+K+
Sbjct: 620 LSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMEN 679
Query: 930 -----------HELEKIGLNKERLLHDEQSTDDRYK----------------LLE--SKL 960
H+LE+ +L ++ + + K LLE +K
Sbjct: 680 EKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKY 739
Query: 961 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1020
E T+++ + +AL+ E NQ+ E+ +KKN E + E + V SS
Sbjct: 740 EKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSS- 798
Query: 1021 PISGEDNKWERESQETTRELLKVKDRLIE-VERNNATLQAEKQALKTQLKQLETQNNNLQ 1079
E Q+ +L+ K+ IE ++ ++ LQ E L+ +N L+
Sbjct: 799 ---------SLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALR----KNEILR 845
Query: 1080 AQILALQRQTVSLQEQNTTLQTQNAKLQVENS---------TLNSQSTSLMNQNAQLLIQ 1130
I R S++E+N LQ + +L+ E S TL+S T L ++ +QL
Sbjct: 846 QTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDS-VTELASEVSQLNTI 904
Query: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH--ERQASEYESLISKHGTLKSAHK 1188
+ LE E + K ED ++ K++LL + Q E + +H + + H
Sbjct: 905 KEHLEEEIKHHQKIIED---------QNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHT 955
Query: 1189 NLEVEHRDLEDRYNQLLKQ-KGQLEDLEKMLKVEQEKMLLENK----NHETVAAEYKKLC 1243
L +E + + ++Q K QL + + ++ + + E K N E + ++
Sbjct: 956 QLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSK 1015
Query: 1244 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1303
E +RL + +E E+ + KN+ +L + E KL + QQ D+
Sbjct: 1016 AETERLVKGIKE--RELEIKLLNEKNISLTKQIDQLSKD----EVGKLTQIIQQKDLEIQ 1069
Query: 1304 KLNNQCELLSQLKGNLEEENRHLLDQIQT-LMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1362
L+ + S ++ +L Q+Q M + + N ++++ H++ + K+
Sbjct: 1070 ALHARISSTSH-----TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH--KM 1122
Query: 1363 NELRRQKEKLEEKIMDQYKFYD---PSPPRRRGNWITLKMRKLIKSKK-DINRERQKSLT 1418
++ KE K+ D+ K S + + ++I+ K +I+ QK T
Sbjct: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQT 1182
Query: 1419 LTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLED 1451
L SS G ++ V SN E+
Sbjct: 1183 LLAVLQTSSTG---------NEAGGVNSNQFEE 1206
Score = 127 bits (320), Expect = 8e-29
Identities = 252/1255 (20%), Positives = 509/1255 (40%), Gaps = 196/1255 (15%)
Query: 66 KKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEV---- 121
KKV D + L + ++ +E L +SL I+ + E+G E
Sbjct: 669 KKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIV-ETLKMEKGEIEAELCW 727
Query: 122 -KKLLLLLLGCAVQCQKKEEFIERIQGL-DFDTKAAVAAHIQEVTHNQENVFDLQWMEVT 179
KK LL + K E+ IE + + +T A H + NQ+ ME+
Sbjct: 728 AKKRLL------EEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD-----MEIA 776
Query: 180 DMSQEDIEPLLKNMALHLKRLIDERD-EHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
+ LK+ I++ D +H ET LS + L + +
Sbjct: 777 E----------------LKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKL 820
Query: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
+ ++ ++ L + + A K LRQ +EEK L K+E ++ EL+RL++E
Sbjct: 821 KERSSKLQEELD-KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRT 879
Query: 299 --LSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVL 356
++D ++ LD++ E A V S+++ KE L EE+K +++
Sbjct: 880 APVADPKT-------LDSVTELASEV----SQLNTIKEHLE---------EEIKHHQKII 919
Query: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE--------EL 408
+ L+ + + ++ E ++ Q+ A + +E+D + K ++ +L
Sbjct: 920 EDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 979
Query: 409 MEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE ++ E+ +E S +LS+A + L + E + L +
Sbjct: 980 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKE-RELEIKLLNEK 1038
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS 528
N SLTK +++L + ++ K+ + Q+ +++ L I + Q+ L
Sbjct: 1039 NISLTKQIDQL---------SKDEVGKLTQIIQQKDLEIQALHARISSTSHT-QDVVYLQ 1088
Query: 529 KDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKE 588
+ L + EK L E + +EN HL + A +K ++ E
Sbjct: 1089 QQLQAYAMEREKVFAVLNEKT--------RENSHLKTEYHKMMDIVAAKEAALIK-LQDE 1139
Query: 589 NKIL--------HESIKETSSKLSKIEFEK-----------RQIKKELEHYKEKGERAEE 629
NK L + +ET LS+I EK + + L+ E
Sbjct: 1140 NKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGV 1199
Query: 630 LENELHHLEKENELLQKKITNLKITCEKI----EALEQENSELERENRKLKKTL--DSFK 683
N+ L +E + L++++ ++ +++ + ++ E+++L+ E +L+ + DS
Sbjct: 1200 NSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDN 1259
Query: 684 NLTFQ------LESLEKENSQLDEENLELRRNVESL----KCASMKMAQLQLENKELESE 733
N Q ++S E+ ++L EL + S+ + + +L + + +L S
Sbjct: 1260 NSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSA 1319
Query: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
+ E L+AS K+E L S ++ LQ+ LE K +Q+ ++ ++
Sbjct: 1320 SLLTPQSAECLRAS--KSEVLSES-------SELLQQELEELRKSLQEKDATIR------ 1364
Query: 794 QTLQKNLEELKISSKRLEQLE-KENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
TLQ+N L S +LE KE++ + E QL++ + L+K K + K L
Sbjct: 1365 -TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL 1423
Query: 853 EENNVKIGNLEKENKTLSKEIGIYKESCVRLK----ELEKENKELVKRATIDIKTLVTLR 908
+N N EN+ L + + KE + L+ +L+ EN+++V+ + T
Sbjct: 1424 LSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVET----YRGKETEY 1479
Query: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD-EQSTDDRYKLLESKLESTLKKS 967
+ L +K M + E H +++ L E+LL + EQ L + ++S +K+
Sbjct: 1480 QALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKT 1539
Query: 968 LEIKEEK----IAALEARLEESTNYNQQLRQELKTVKKNYEALKQR-------------- 1009
+ ++E+ +A + ++E + N+ R K + N E + R
Sbjct: 1540 VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREA 1599
Query: 1010 ---QDEERMVQSSPPISGE-----DNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
+D E ++ + E N E S + + ++ ++++L V + +
Sbjct: 1600 LAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQL 1659
Query: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
+ Q+KQ NLQ + Q++ ++ +A+L+ + + +
Sbjct: 1660 SVSQEQVKQYALSLANLQMVLEHFQQEEKAM---------YSAELEKQKQLIAEWKKNAE 1710
Query: 1122 NQNAQLLIQQSSLENENESV-----IKEREDLKSLYDSLIKDHEKL--ELLHERQASEYE 1174
N +++ Q L+ N ++ + E+ D+K +K +L E+L + Q
Sbjct: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMS 1770
Query: 1175 SLISKHGTL-KSAHKNLEVEH-RDLEDRYNQLLKQKGQL-----EDLEKMLKVEQ 1222
S G + K +NL + H +++ +++L+ G + E++E++ +Q
Sbjct: 1771 LANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHDDQ 1825
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 184 bits (466), Expect = 9e-46
Identities = 285/1310 (21%), Positives = 579/1310 (44%), Gaps = 227/1310 (17%)
Query: 255 DAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA 314
DA + +R L + + + D +Q+L + + LQQ++ + ++ R +L
Sbjct: 383 DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTG 442
Query: 315 LREK-AVRVDKLESEV-SRYKERLHDIEFYKARVEELKEDNQVLLET-----KTMLEDQL 367
R+ A + L+ EV S KER E + EEL++ +VL + + +E QL
Sbjct: 443 ERDTLAGQTVDLQGEVDSLSKER----ELLQKAREELRQQLEVLEQEAWRLRRVNVELQL 498
Query: 368 EGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESL 427
+G A+ K + E+ +L ++ + EM ++ K+ E L E +TL A ES
Sbjct: 499 QGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESL-SELITLREAL-----ESS 552
Query: 428 HLGWEL---EQISRTSELSEAPQK---------SLGHEVNELTSS--------------- 460
HL EL EQ T+ L+ A Q +L EV +L ++
Sbjct: 553 HLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEALALDK 612
Query: 461 -----RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIV 515
+LL+LE ENQS+ +E ++++ + + + EK + L +K LE ++
Sbjct: 613 VGLNQQLLQLEEENQSVCSRMEAAEQARNALQVD---LAEAEKRREALWEKNTHLEAQLQ 669
Query: 516 QEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER---QIKILEQENEHLNQTVSSLRQ 572
+ +++ Q +D+ +EK +++K + R E Q++ L QE + + ++ Q
Sbjct: 670 KAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQ 729
Query: 573 ------RSQISAEARVKDIEKENKILHESIKETSSKLSKIE---FEKRQIKKELEHYKEK 623
R + + E R++ +E++ + L E ++ SS +E FE +Q +E K
Sbjct: 730 EKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKG- 788
Query: 624 GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELEREN----RKLKKTL 679
+LE ++ + + E++Q ++ LK+ L+ E S+ E+E R+L +
Sbjct: 789 -----QLEVQIQTVTQAKEVIQGEVRCLKLE------LDTERSQAEQERDAAARQLAQAE 837
Query: 680 DSFKN-LTFQLESLEKENSQLDEE--------NLELRRNVESLKCASMKMAQLQLENKEL 730
K L Q + EKE +QL E+ EL + +ESL+ M++ +++L+ ++
Sbjct: 838 QEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMEL-EMRLKEQQT 896
Query: 731 ESEKEQLKKGLELLKASFKKTE-RLEVSYQGLDIENQRLQ--KTLENSNKKIQQLESELQ 787
E E Q ++ E +A + +LE + + + LQ K L ++++++++L +++
Sbjct: 897 EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMK 956
Query: 788 DLEMENQT----LQKNLEELKISSKRLEQLEKEN-KSLEQETSQLEKDKKQLEKENKRLR 842
+++ Q LQ L+E + K + +++ +L++E+S L +DK L+K+ + L+
Sbjct: 957 VQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLK 1016
Query: 843 QQAEIKDTTL----EENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT 898
Q +D + +E K+ ++ N+ + KE+ K S + L +EKE + LV +
Sbjct: 1017 SQLVAQDDSQRLVEQEVQEKLRETQEYNR-IQKELEREKAS-LTLSLMEKEQRLLVLQEA 1074
Query: 899 IDIKT--LVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLL 956
I+ L LR+D+ + + ++++ +E L E+++ + L + Q ++ L
Sbjct: 1075 DSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKE--KEADFLAQEAQLLEE----L 1128
Query: 957 ESK--LESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT---------VKKNYEA 1005
E+ E L+ SL +E K A L+ RL + + + L E + + Y A
Sbjct: 1129 EASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSA 1188
Query: 1006 LKQRQDEERMVQSSPPISGEDNK----WERE--------------------SQETTRELL 1041
L+Q + +S P +SG + W E ++ L
Sbjct: 1189 LQQALGS--VCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALH 1246
Query: 1042 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1101
K+ L + ++ L+ + Q L+ +L E + + + ++ LQRQ QE+ + +
Sbjct: 1247 KLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEG 1306
Query: 1102 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENE------------------SVIK 1143
+ L+ E L+ SL ++ + +Q+ + E E +V++
Sbjct: 1307 KQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVE 1366
Query: 1144 ER----------EDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVE 1193
R EDL++ +L +E++E ER + E K K+ +NL +
Sbjct: 1367 ARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALL 1426
Query: 1194 HRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLL-------ENKNHETVAAEYKKLCGEN 1246
+ L +R ++ +GQ+++LEK ++++ + L N+ + + ++L
Sbjct: 1427 TQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCR 1486
Query: 1247 DRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQ---------- 1296
L H + + + L + ++ L + + ++ LE + +L+++ Q
Sbjct: 1487 SVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQ 1546
Query: 1297 --------------QLDITSTKLNNQCELLSQLKG--------------NLEEENRHLLD 1328
+L+ K+ Q +L+ +L+G +LEE ++ L
Sbjct: 1547 DLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQA 1606
Query: 1329 QIQTL--MLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
Q + + + T+L + ++ +D QR+ I+ EL+RQKE L + +
Sbjct: 1607 QSSQIHDLESHSTVLARELQERDQEVKSQREQIE---ELQRQKEHLTQDL 1653
Score = 155 bits (391), Expect = 5e-37
Identities = 287/1384 (20%), Positives = 572/1384 (41%), Gaps = 229/1384 (16%)
Query: 132 AVQCQKKEEFIERIQGL---DFDTKAAVAAHIQEVTHNQENVFDL--------QWMEVTD 180
A+Q Q++EE + L +T+ + ++ + Q+ + D Q M+V
Sbjct: 900 AIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQK 959
Query: 181 MSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGM 240
+ +++ +L+ +R + E + RD L L SSS
Sbjct: 960 LKEQETTGILQTQLQEAQRELKEAAR---------QHRDDLAALQEESSSL--------- 1001
Query: 241 KRTESRQHLSVELADAKAKI-------RRLRQELEEK---TEQLLDCKQELEQMEIELK- 289
+ + L ++ D K+++ R + QE++EK T++ ++ELE+ + L
Sbjct: 1002 --LQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTL 1059
Query: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
L ++ LL + + + EL ALR+ + E+S E L +E+
Sbjct: 1060 SLMEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLR---------QEV 1110
Query: 350 KEDNQVLLETKTMLEDQLEGTRARSDKLHEL----EKENLQLKAKLHDMEMERDMDRKKI 405
KE L + L ++LE + +L E + QL+ +L E + +
Sbjct: 1111 KEKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQ-------L 1163
Query: 406 EELMEENMTLEMAQKQSMDESLH------LGWELEQISRTSELSEAPQKSLGHEVNELTS 459
E L E AQ Q+ SL+ LG E S ++ G E ++ +
Sbjct: 1164 EALAAEQQPGNQAQAQAQLASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGA 1223
Query: 460 SRLLK----------------LEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRL 503
L K L +Q L KT + D V+ ++ E E ++
Sbjct: 1224 RSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQV 1283
Query: 504 SKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER----------QI 553
+++ L+ ++ Q ++ + L E +L +T+ +L+ R +
Sbjct: 1284 HTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGER 1343
Query: 554 KILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQI 613
++L+ E+L V L Q + + A A+ IL E ++ S L
Sbjct: 1344 ELLQAAKENLTAQVEHL-QAAVVEARAQASAAG----ILEEDLRTARSAL---------- 1388
Query: 614 KKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITC----EKIEALEQENSELE 669
K + E + + ERA+ L+ + + + LQ+ + L T E++E L + ELE
Sbjct: 1389 KLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE 1448
Query: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCAS----MKMAQLQL 725
++ K L+ L+K N ++D + +++ E KC S + MA +
Sbjct: 1449 KQREMQKAALELLSL------DLKKRNQEVDLQQEQIQ---ELEKCRSVLEHLPMAVQER 1499
Query: 726 ENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE 785
E K L ++EQ++ EL K ++T+R + +Q L++E + + +E+ ++Q L+ +
Sbjct: 1500 EQK-LTVQREQIR---ELEKD--RETQRNVLEHQLLELEKK--DQMIESQRGQVQDLKKQ 1551
Query: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
L LE L++N +++ K +++LE + ++ + L D LE+ ++ L+ Q+
Sbjct: 1552 LVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLD---LEERSQELQAQS 1608
Query: 846 EIKDTTLEENNVKIGNLEKENKTLSKEI----GIYKESCVRLKELEKENKELVKRATIDI 901
+I +LE + L++E+ K +++EL+++ + L +
Sbjct: 1609 S-----------QIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRD 1657
Query: 902 KTLVTLREDL-VSEKLKTQQ---MNNDLEKLTHELEKIG--LNKERLLHDEQSTDDR--Y 953
+ L+ +E + V E +T+Q + DLE++ L + G L +R L E++ + +
Sbjct: 1658 QELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPS 1717
Query: 954 KLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL----KTVKKNYEALKQR 1009
K LE +K L KE+++ + + E QL Q+L + V + L QR
Sbjct: 1718 KAQRGSLEH-MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776
Query: 1010 QDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLK 1069
+ E ++Q + E + + +S ++ +L E +R A E +AL+ + +
Sbjct: 1777 EQEIVVLQQQLQEAREQGELKEQS---------LQSQLDEAQRALAQRDQELEALQQEQQ 1827
Query: 1070 QLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI 1129
Q + Q ++ + ALQ +L++ + TL+ ++ +LQ + A+ L
Sbjct: 1828 QAQGQEERVKEKADALQG---ALEQAHMTLKERHGELQDH------------KEQARRLE 1872
Query: 1130 QQSSLENENESVIKE-REDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHK 1188
++ ++E ++E DL+ + ++ EK L ++Q +E +
Sbjct: 1873 EELAVEGRRVQALEEVLGDLR----AESREQEKALLALQQQCAEQA-------------Q 1915
Query: 1189 NLEVEHRDLEDRYNQ---LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGE 1245
EVE R L+D + Q +LK++ Q +LE + Q E A + L
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQ--ELEALRAESQSSRHQEEAARARAEALQEALGKA 1973
Query: 1246 NDRLNHTYSQLLKETEV---LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITS 1302
+ L LL++ E+ L+ L++ L+ + +LE + + Q D+
Sbjct: 1974 HAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL-- 2031
Query: 1303 TKLNNQCELLSQLKGNLEEENRH-----------LLDQIQTLMLQNRTLLEQNMESKDLF 1351
+ + L Q +EE RH L ++Q M+Q + L Q E +++
Sbjct: 2032 -RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIR 2090
Query: 1352 HVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINR 1411
+ Q +L ++++E LE + Q + P + + + + KL + + R
Sbjct: 2091 GLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPRLQR 2150
Query: 1412 ERQK 1415
E ++
Sbjct: 2151 ELER 2154
Score = 147 bits (371), Expect = 9e-35
Identities = 232/1056 (21%), Positives = 467/1056 (44%), Gaps = 130/1056 (12%)
Query: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKR------LQ 292
G E+ L+ LA+ + ++ LR +++E +Q K LE + ++LK+ LQ
Sbjct: 1416 GKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475
Query: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352
QE + L RS L + V + E +++ +E++ ++E + + E
Sbjct: 1476 QEQIQELEKCRSV---------LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEH 1526
Query: 353 NQVLLETKT-MLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEE 411
+ LE K M+E Q + +L LE L+L+ H ME ++ K I+EL +
Sbjct: 1527 QLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQ----KLIKELEGQ 1582
Query: 412 NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNE---LTSSRLLKLEME 468
T +A HL +LE+ R+ EL Q S H++ + + L + + E
Sbjct: 1583 RETQRVALT-------HLTLDLEE--RSQELQA--QSSQIHDLESHSTVLARELQERDQE 1631
Query: 469 NQSLTKTVEELRT-----TVDSVEGNASKILKMEK----ENQRLSKKVEILENEIVQEKQ 519
+S + +EEL+ T D + +L+ E+ E+QR +++ +ILE ++ Q K
Sbjct: 1632 VKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLEDQR-TRQTKILEEDLEQIKL 1690
Query: 520 SLQNCQN---LSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQI 576
SL+ + LM+E+A+ K + S +K++ ++ E + Q+ I
Sbjct: 1691 SLRERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVEC-----QQEHI 1745
Query: 577 SAEARVKD-IEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEE-LENEL 634
+KD +E++ + LH + ETS LS+ E E ++++L+ +E+GE E+ L+++L
Sbjct: 1746 HELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQL 1805
Query: 635 HHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE-SLE 693
E + L Q+ +++EAL+QE + + + ++K+ D+ + Q +L+
Sbjct: 1806 D--EAQRALAQRD--------QELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLK 1855
Query: 694 KENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESE-KEQLKKGLELLKASFKKTE 752
+ + +L + + RR E L ++ L+ +L +E +EQ K L L + ++ +
Sbjct: 1856 ERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQ 1915
Query: 753 RLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK-------- 804
EV + L + Q L+ +++++ L +E Q + + + E L+
Sbjct: 1916 EHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHA 1975
Query: 805 -ISSKRLEQLEKE--NKSLEQETSQLEKDKKQLEKENKRLR-----QQAEIKDTTLE--- 853
+ K LE+ ++SLE T+ L+ + +++L Q+ EI+D L
Sbjct: 1976 ALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQE 2035
Query: 854 ----------ENNVKIGNLEKENKTLSKEIGI-YKESCVRLKE---LEKENKEL--VKRA 897
+ + ++ + ++ + L K + +E+ ++ K+ E+E +E+ + ++
Sbjct: 2036 DVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQS 2095
Query: 898 TIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD--EQSTDDRYKL 955
+++ + +E + E +TQQ NN LE L H + + ++ L D E +
Sbjct: 2096 VRELQLTLAQKEQEILELRETQQRNN-LEALPHSHKTSPMEEQSLKLDSLEPRLQRELER 2154
Query: 956 LESKLESTLKKSLEIKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQR-QDE 1012
L++ L T + +E +E + +A A+ + S + Q++ L+ ++ +QR QDE
Sbjct: 2155 LQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDE 2214
Query: 1013 ERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE------VERNNATLQAEKQALKT 1066
+ + + E + +T EL ++ ++ VE + EKQ+ +
Sbjct: 2215 LELTRRAL----EKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQ 2270
Query: 1067 QLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVE-NSTLNSQSTSLMNQNA 1125
+L+ L+ L+ LQR V L+ ++ + KL+ E + S + A
Sbjct: 2271 RLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEISKATA 2330
Query: 1126 QLLIQQSSLENEN---ESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGT 1182
QQ +N + V + ++++ L L + ++ + R A L H +
Sbjct: 2331 SSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHS 2390
Query: 1183 LKSA---------HKNLEVEHRDLEDRYNQLLKQKG 1209
L + LE E R L++ Q L G
Sbjct: 2391 LSHSLLAVAQAPEATVLEAETRRLDESLTQSLTSPG 2426
Score = 144 bits (363), Expect = 8e-34
Identities = 230/1251 (18%), Positives = 521/1251 (41%), Gaps = 151/1251 (12%)
Query: 241 KRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLS 300
+ + ++ L E A + +++ + ++ ++ EQL E +E L QQ+N +
Sbjct: 726 RAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEV 785
Query: 301 DARSARMYRDELDALRE---KAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLL 357
+ + +E VR KLE + R + + + +E L
Sbjct: 786 TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE 845
Query: 358 ETKTMLEDQLEGTRARSDK------------LHELEKENLQLKAKLHDMEMERDMDRKKI 405
+ K E ++ R + +K L LE+E ++L+ +L + + E + + +
Sbjct: 846 QQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQR 905
Query: 406 EE--------LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNEL 457
EE L + + E + ++ L EL S+ E K + E
Sbjct: 906 EEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQET 965
Query: 458 TSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK----MEKENQRLSKKV------ 507
T +L+ + L + + R + +++ +S +L+ ++K+ + L ++
Sbjct: 966 TGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDS 1025
Query: 508 -EILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQT 566
++E E+ ++ + Q + K+L +EKA L ++ E+++ +L++ + Q
Sbjct: 1026 QRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSL----MEKEQRLLVLQEADSIRQQE 1081
Query: 567 VSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE--HYKEKG 624
+S+LRQ Q A+ K++ + ++L + +KE K + ++ Q+ +ELE H E
Sbjct: 1082 LSALRQDMQ-EAQGEQKELSAQMELLRQEVKE---KEADFLAQEAQLLEELEASHITE-- 1135
Query: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENR------KLKKT 678
++L L E + LQ ++ + + E + A +Q ++ + + + L++
Sbjct: 1136 ---QQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192
Query: 679 LDSFKNLTFQLE--------------------------------SLEKENSQLDEENLEL 706
L S +L S E S L + + +L
Sbjct: 1193 LGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDL 1252
Query: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQG----LD 762
+ ++ ++ +L+ + E+EK Q+ L+ L+ + + + ++G L+
Sbjct: 1253 WKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLE 1312
Query: 763 IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQ 822
E L +T+ + ++++ E + + + E + LQ E L + L+ E ++
Sbjct: 1313 SELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQAS 1372
Query: 823 ETSQLEKD----KKQLEKENKRLRQQAEIKDTTLEENNVKI--GNLEKENKTLSKEIGIY 876
LE+D + L+ +N+ + + E E+ +K+ G +EN L +
Sbjct: 1373 AAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAE 1432
Query: 877 KESCV-----RLKELEKE---NKELVKRATIDIKTL---VTLREDLVSEKLKTQQMNNDL 925
+E V +++ELEK+ K ++ ++D+K V L+++ + E K + + L
Sbjct: 1433 REEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHL 1492
Query: 926 EKLTHELE-KIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEK---------I 975
E E K+ + +E++ E+ + + +LE +L KK I+ ++ +
Sbjct: 1493 PMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQL 1552
Query: 976 AALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQE 1035
LE E + ++ + K +K+ L+ +++ +R+ + + E+ E ++Q
Sbjct: 1553 VTLECLALELEENHHKMECQQKLIKE----LEGQRETQRVALTHLTLDLEERSQELQAQS 1608
Query: 1036 TTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLE---------TQNNNLQAQILALQ 1086
+ L+ ++ E LQ Q +K+Q +Q+E TQ+ + Q L LQ
Sbjct: 1609 SQIHDLESHSTVLARE-----LQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQ 1663
Query: 1087 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1146
++ + + E T QT+ + +E L+ + + L+Q+ + E + S +R
Sbjct: 1664 KERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSK-AQRG 1722
Query: 1147 DLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLK 1206
L+ + +++D EK + E + L + + L+ HR + + L +
Sbjct: 1723 SLEHM-KLILRDKEKEVECQQEHIHELQELKDQ------LEQQLQGLHRKVGETSLLLSQ 1775
Query: 1207 QKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDR----LNHTYSQLLKETEV 1262
++ ++ L++ L+ +E+ L+ ++ ++ E ++ + D+ L Q + E
Sbjct: 1776 REQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEER 1835
Query: 1263 LQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEE 1322
++ L+ L + + E KEQ ++L+ + + L ++ G+L E
Sbjct: 1836 VKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAE 1895
Query: 1323 NRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLE 1373
+R +Q + L+ + EQ E + Q ++ L+ + ++LE
Sbjct: 1896 SR---EQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELE 1943
Score = 106 bits (264), Expect = 2e-22
Identities = 214/1019 (21%), Positives = 422/1019 (41%), Gaps = 133/1019 (13%)
Query: 467 MENQSLTKTVEE--LRTTVDSVEGNAS---KILKMEKENQRLSKKVEILENEIVQEKQSL 521
M+ QSL +EE L E A+ K+ ++ QR + V L+ +++Q +
Sbjct: 11 MKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSW- 69
Query: 522 QNCQNLSKDLMKEKAQLEKTIETLRE-NSERQIKILEQEN---EHLNQTVSSLR---QRS 574
CQ L K L + + E + E N + + LE+E E L + + LR +++
Sbjct: 70 --CQELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKA 127
Query: 575 QISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL--EHYKEKGERAEELEN 632
+ +A +D+EK + E K S+ + E+ K L EH + E +
Sbjct: 128 DVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTF 187
Query: 633 ELHHLEKEN----ELLQKKITNLKIT------CEKIEALEQE---NSELERENRK----- 674
H LE ++ +L++ K +++++ C ++ Q N + R+
Sbjct: 188 RRHFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLL 247
Query: 675 --LKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELES 732
L KT + K + + L + SQ D E EL+ V L S + Q Q +N++ E
Sbjct: 248 LLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTEL---SALLTQSQKQNEDYEK 304
Query: 733 EKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEME 792
+ L++ +E+L+ + + E S L Q + +L+ K I Q+ E D +
Sbjct: 305 MIKALRETVEILETNHTELMEHEAS---LSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQ 361
Query: 793 NQTLQKNLEELKISSKRLEQLEKEN--KSLEQETSQLEKDKKQLEKENKRLRQQAEIKDT 850
+ +LE + S Q + ++ K+L S L + ++ ++ ++L E +
Sbjct: 362 GSGHENSLE---LDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNL 418
Query: 851 TLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLRED 910
++++ E+E K L + RL++L E L + T+D++ V +
Sbjct: 419 LQQQHD----QWEEEGKALRQ----------RLQKLTGERDTLAGQ-TVDLQGEV---DS 460
Query: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEI 970
L E+ Q+ +L + LE+ R+ + Q D + + + + L ++
Sbjct: 461 LSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE 520
Query: 971 KE---EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDE-----ERMVQSSPPI 1022
+E E + LEA+ ES + LR+ L++ E L+Q Q E R QS +
Sbjct: 521 RERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAEL 580
Query: 1023 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1082
S +N + E + ++ +++ N L +K L QL QLE +N ++ +++
Sbjct: 581 SSSENTLKTEVAD-------LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRM 633
Query: 1083 LALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVI 1142
A ++ +LQ + + L +N+ L +Q A+L ++ E E +
Sbjct: 634 EAAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQ 693
Query: 1143 K-------EREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR 1195
K ++E + + L ++ ++ E + R E E+L+ + L+ + +E + +
Sbjct: 694 KKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQ 753
Query: 1196 DLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQ 1255
DL ++ L K LE + + +Q+ ++E +L
Sbjct: 754 DLAEQLQGLSSAKELLE--SSLFEAQQQNSVIE---------------VTKGQLEVQIQT 796
Query: 1256 LLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQL 1315
+ + EV+Q + + LK +L+ R +AE Q+ D + +L
Sbjct: 797 VTQAKEVIQGEVRCLK-----LELDTERSQAE--------QERDAAARQL---------- 833
Query: 1316 KGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
E+E + L+Q + + L + E + +H Q++ L L R+K +LE +
Sbjct: 834 -AQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWH--QQELAKALESLEREKMELEMR 890
Query: 1376 IMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSL-TLTPTRSDSSEGFLQL 1433
+ +Q + +R T L + + + +ER L TL T+ + ++ QL
Sbjct: 891 LKEQQTEMEAIQAQREEE-RTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQL 948
Score = 84.3 bits (207), Expect = 1e-15
Identities = 158/702 (22%), Positives = 305/702 (43%), Gaps = 102/702 (14%)
Query: 190 LKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHL 249
L++M L L+ E + E I EL E +D L G + ++ Q +
Sbjct: 1724 LEHMKLILRDKEKEVECQQEHIHELQELKDQLE---QQLQGLHRKVGETSLLLSQREQEI 1780
Query: 250 SV---ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSAR 306
V +L +A+ + Q L+ QL + ++ L Q + EL+ LQQE + + R
Sbjct: 1781 VVLQQQLQEAREQGELKEQSLQS---QLDEAQRALAQRDQELEALQQEQQQ--AQGQEER 1835
Query: 307 MYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQ 366
+ +++ DAL+ LE KER +++ +K + L+E+ V LE+
Sbjct: 1836 V-KEKADALQ------GALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEV 1888
Query: 367 LEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEE--------LMEENMTLEMA 418
L RA S E EK L L+ + + E +++ + +++ L E + LE
Sbjct: 1889 LGDLRAES---REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEAL 1945
Query: 419 QKQSMDESLHLGWELEQISRTSELSEAPQKSLG--HEVNELTSSRLLKLEMENQSLTKTV 476
+ +S E+ +R +EA Q++LG H + LL+ ++SL +
Sbjct: 1946 RAESQSSR-----HQEEAARAR--AEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998
Query: 477 EELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
L+ ++D+ + ++ ++L + + I E EI + Q +D+ + +
Sbjct: 1999 ATLQASLDACQAHS----------RQLEEALRIQEGEIQDQDLRYQ------EDVQQLQQ 2042
Query: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
L + E LR ER+ ++LE+ Q + ++++ + E E+E + LH+S+
Sbjct: 2043 ALAQRDEELRHQQERE-QLLEKSLAQRVQE-NMIQEKQNLGQERE----EEEIRGLHQSV 2096
Query: 597 KETSSKLSK-----IEFEKRQIKKELEH--YKEKGERAEELENELHHLEKENELLQKKIT 649
+E L++ +E + Q + LE + K EE +L LE LQ+++
Sbjct: 2097 RELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSLEPR---LQRELE 2153
Query: 650 NLKITCEKIEALE----QENSELERENRKLKKTLDSFKNLTFQLES--LEKENSQLD-EE 702
L+ + EA E ++ +L + K ++ S + + L++ LE+++ Q ++
Sbjct: 2154 RLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQD 2213
Query: 703 NLEL-RRNVESLKCAS---MKMAQLQLENKELES-------EKEQLKKGLELLKASFK-K 750
LEL RR +E + S A+L ++ E E G+E K S++ +
Sbjct: 2214 ELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGME--KQSWRQR 2271
Query: 751 TERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKN-LEELKISSKR 809
E L+ + L+I+ RLQ + QL S L+ +E E + L++ + + S
Sbjct: 2272 LEHLQQAVARLEIDRSRLQ-------RHNVQLRSTLEQVERERRKLKREAMRAAQAGSLE 2324
Query: 810 LEQLEKENKSLEQETSQLEKDKK---QLEKENKRLRQQAEIK 848
+ + + + + Q D K +L+KE L+ Q ++
Sbjct: 2325 ISKATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLE 2366
Score = 58.9 bits (141), Expect = 4e-08
Identities = 108/543 (19%), Positives = 226/543 (41%), Gaps = 60/543 (11%)
Query: 116 QGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQW 175
+ E+ K LL L CA Q Q+ E +T+A + +Q +E +L+
Sbjct: 1895 ESREQEKALLALQQQCAEQAQEHE----------VETRALQDSWLQAQAVLKERDQELEA 1944
Query: 176 MEVTDMSQEDIEPLLKNMALHLKRLIDE-------RDEHSETIIELSEERDGLHFLPHAS 228
+ S E + A L+ + + +++H ELS + AS
Sbjct: 1945 LRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQAS 2004
Query: 229 SSAQSPCGSPGMKRTESRQHLSVELADAKAK----IRRLRQELEEKTEQLLDCKQELEQM 284
A C + + E+ + E+ D + +++L+Q L ++ E+L ++ + +
Sbjct: 2005 LDA---CQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLL 2061
Query: 285 EIELKRLQQENM----NLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKE--RLHD 338
E L + QENM L R R ++RE + + + E E+ +E + ++
Sbjct: 2062 EKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNN 2121
Query: 339 IEF--YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396
+E + + ++E + L + L+ +LE +A L + E ++ + K D+ +
Sbjct: 2122 LEALPHSHKTSPMEEQSLKLDSLEPRLQRELERLQA---ALRQTEAREIEWREKAQDLAL 2178
Query: 397 ERDMDRKKIEELMEENMTLEM------AQKQSMDESLHL---GWELEQISRTSELSEAPQ 447
+ + L E M L+ +++Q + + L L E E++ S A
Sbjct: 2179 SLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAEL 2238
Query: 448 KSLGHEVNELTSSRLLKLE-----MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQR 502
S G + +L ++ E ME QS + +E L+ V +E + S ++++ N +
Sbjct: 2239 GSRGEQGVQLGEVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRS---RLQRHNVQ 2295
Query: 503 LSKKVEILENEIVQ-EKQSLQNCQNLSKDLMKEKAQLEKTIETL-RENSERQIKILEQEN 560
L +E +E E + ++++++ Q S ++ K A + ++NS+ + Q+
Sbjct: 2296 LRSTLEQVERERRKLKREAMRAAQAGSLEISKATASSPTQQDGRGQKNSDAKCVAELQKE 2355
Query: 561 EHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKET------SSKLSKIEFEKRQIK 614
L Q +L ++ + R +E LH S+ + + + + +E E R++
Sbjct: 2356 VVLLQAQLTLERKQKQDYITRSAQTSRELAGLHHSLSHSLLAVAQAPEATVLEAETRRLD 2415
Query: 615 KEL 617
+ L
Sbjct: 2416 ESL 2418
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 180 bits (457), Expect = 1e-44
Identities = 249/1145 (21%), Positives = 495/1145 (43%), Gaps = 165/1145 (14%)
Query: 265 QELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK 324
+EL + E+ L + L +ME +L E + L +++L A E ++
Sbjct: 852 EELVKVREKQLAAENRLTEMETLQSQLMAEKLQL----------QEQLQAETELCAEAEE 901
Query: 325 LESEVSRYKERL----HDIEFYKARVEELKEDNQVL-LETKTM------LEDQLEGTRAR 373
L + ++ K+ L HD+E ARVEE +E Q L E K M LE+QLE +
Sbjct: 902 LRARLTAKKQELEEICHDLE---ARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESA 958
Query: 374 SDKLHELEKENLQLKAK--------LHDMEMERDMDRKKIEELM---------EENMTLE 416
KL +LEK + K K L D + ++K +E+ + EE +
Sbjct: 959 RQKL-QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKS 1017
Query: 417 MAQKQSMDESLHLGWE---------LEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
+A+ ++ E++ E +++ +T E L ++ EL +++ +L+M
Sbjct: 1018 LAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAEL-QAQIAELKM 1076
Query: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
+ L K EEL+ + VE A++ K+ + L ++ L+ ++ E+ S +
Sbjct: 1077 Q---LAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQ 1133
Query: 528 SKDLMKE----KAQLEKTIET------LRENSERQI----KILEQENEHLNQTVSSLRQR 573
+DL +E K +LE T+++ LR E+++ K LE+E + + +RQ+
Sbjct: 1134 KRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQK 1193
Query: 574 SQISAEARVKDIEKENKI---LHESIKETSSKLSKIEFEKR---QIKKELEHYKEKGE-R 626
+ E + +E+ ++ L ++ + ++ ++ E + Q K + EH ++K E +
Sbjct: 1194 HSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQ 1253
Query: 627 AEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT 686
+EL+ + + E+ L K+T L++ + + L L + + K K F L
Sbjct: 1254 LQELQVKFNEGERVRTELADKVTKLQVELDNVTGL------LSQSDSKSSKLTKDFSALE 1307
Query: 687 FQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKA 746
QL+ ++ L EEN + LK + + + +E E K L+K + L A
Sbjct: 1308 SQLQDTQE---LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHA 1364
Query: 747 SF----KKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEE 802
KK E + + ++LQK LE +++ ++ + LE LQ+ L++
Sbjct: 1365 QVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDD 1424
Query: 803 LKISSKRLEQ----LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVK 858
L + Q LEK+ K +Q ++ + + +E R +A
Sbjct: 1425 LLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR------------ 1472
Query: 859 IGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKT 918
EKE K LS + +E+ + ELE+ NK+ T EDL+S K
Sbjct: 1473 ----EKETKALSLARAL-EEAMEQKAELERLNKQ-----------FRTEMEDLMSSK--- 1513
Query: 919 QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLEST--LKKSLEIKEEKIA 976
+D+ K HELEK +K L + + + LE +L++T K LE+ + +
Sbjct: 1514 ----DDVGKSVHELEK---SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566
Query: 977 A-----LEARLEESTNYNQQLRQELKTVKKNYEALKQRQD-----EERMVQSSPPISGED 1026
A L+ R E+S +QL ++++ ++ E ++++ +++ +
Sbjct: 1567 AQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHI 1626
Query: 1027 NKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQ 1086
+ + E ++L K++ ++ + R +A ++ + Q K+ E + +++A+++ LQ
Sbjct: 1627 DSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ 1686
Query: 1087 RQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERE 1146
+ + + Q + +L E + + + + + +L + + LE E E +E+
Sbjct: 1687 EELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELE---EEQG 1743
Query: 1147 DLKSLYDSLIKDHEKLELLH---ERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQ 1203
+ + + D L K + +++ ++ + S + + L+ +K L+V+ +++E
Sbjct: 1744 NTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKS 1803
Query: 1204 LLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAA---------EYKKLCGENDRLNHTYS 1254
K K + LE K+ Q + L+N+ E AA + K + + D
Sbjct: 1804 --KYKASITALE--AKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAE 1859
Query: 1255 QLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1314
Q + + T K LK L ++ E R A KL+ + + T+ +N + +S
Sbjct: 1860 QYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNRE---VSS 1916
Query: 1315 LKGNL 1319
LK L
Sbjct: 1917 LKNKL 1921
Score = 172 bits (437), Expect = 2e-42
Identities = 223/1049 (21%), Positives = 476/1049 (45%), Gaps = 134/1049 (12%)
Query: 137 KKEEFIERIQGLD--FDTKAAVAAHIQ-EVTHNQENVFDLQ-WMEVTDMSQEDIEPLLKN 192
KK+E E L+ + + H+Q E Q+N+ +L+ +E + +++ ++
Sbjct: 909 KKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVT 968
Query: 193 MALHLKRLIDERDEHSETIIELSEERDGLH--FLPHASSSAQSPCGSPGMKRTESRQHLS 250
LK+L +E+ + +L++E+ L ++ + S + + +++
Sbjct: 969 TEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM 1028
Query: 251 VELADAKAKIRR---LRQELEEKTEQL----LDCKQELEQMEIELKRLQQENMNLLSDAR 303
+ D + ++RR RQELE+ +L D ++ +++ ++ L+ + + +
Sbjct: 1029 I--TDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQ 1086
Query: 304 SARMYRDELDALREKAVR-VDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-KT 361
+A +E A + A++ + +LES++S +E L + + E+ K D LE KT
Sbjct: 1087 AALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKT 1146
Query: 362 MLEDQLEGTRARSDKLHELEKE------NLQLKAKLHDMEME--RDMDRKKIEELMEE-- 411
LED L+ T A+ + + E+E L+ +AK H+ +++ R + +EEL E+
Sbjct: 1147 ELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLE 1206
Query: 412 -----NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLE 466
LE A++ +E L E++ + + SE +K + ++ EL + + E
Sbjct: 1207 QTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQEL-QVKFNEGE 1265
Query: 467 MENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQN 526
L V +L+ +D+V G S+ + ++ +L+K LE+++ ++ LQ
Sbjct: 1266 RVRTELADKVTKLQVELDNVTGLLSQ---SDSKSSKLTKDFSALESQLQDTQELLQEENR 1322
Query: 527 LSKDLMKEKAQLEKTIETLRENSERQIKI---LEQENEHLNQTVSSLRQRSQIS------ 577
L + Q+E + RE E + + LE++ L+ V+ ++++ + S
Sbjct: 1323 QKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLET 1382
Query: 578 AEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELE-------HYKEKGERAEEL 630
AE + ++K+ + L + +E + K+E K ++++EL+ H ++ E+
Sbjct: 1383 AEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKK 1442
Query: 631 ENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLE 690
+ + L E + + K A E++ +E E ++ K +L LE
Sbjct: 1443 QKKFDQLLAEEKTISAKY-----------AEERDRAEAEAREKETKAL-----SLARALE 1486
Query: 691 SLEKENSQLDEENLELRRNVESLKCAS----MKMAQLQLENKELESEKEQLKKGLELLKA 746
++ ++L+ N + R +E L + + +L+ + LE + E++K LE L+
Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED 1546
Query: 747 SFKKTE----RLEVSYQGLDIENQR-LQKTLENSNKKIQQLESELQDLEMENQTLQKNLE 801
+ TE RLEV+ Q + + +R LQ E S +K +QL +++++E E + +K
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRS 1606
Query: 802 ELKISSKRLEQ--------LEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL- 852
+ K+LE ++ NK+ ++ QL K + Q++ + L ++ L
Sbjct: 1607 MAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILA 1666
Query: 853 --EENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV---------------K 895
+EN K+ ++E E L +E+ + + ++ ++E EL +
Sbjct: 1667 QAKENEKKLKSMEAEMIQLQEELAAAERA---KRQAQQERDELADEIANSSGKGALALEE 1723
Query: 896 RATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIG--LNKERLLHDEQSTDDRY 953
+ ++ + + L E+L E+ T+ +N+ L+K ++++I LN ER H +++ + R
Sbjct: 1724 KRRLEAR-IAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERS-HAQKNENARQ 1781
Query: 954 KL-------------LESKLESTLKKSLEIKEEKIAALEARLEESTNYNQ-QLRQELKTV 999
+L +E ++S K S+ E KIA LE +L+ T Q +Q +T
Sbjct: 1782 QLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTE 1841
Query: 1000 KKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQA 1059
KK + L Q DE R + +++ ++ + + L ++K +L E E A
Sbjct: 1842 KKLKDVLLQVDDERRNAE----------QYKDQADKASTRLKQLKRQLEEAEEEAQRANA 1891
Query: 1060 EKQALKTQLKQLETQNNNLQAQILALQRQ 1088
++ L+ +L+ + + ++ +L+ +
Sbjct: 1892 SRRKLQRELEDATETADAMNREVSSLKNK 1920
Score = 164 bits (416), Expect = 6e-40
Identities = 214/1014 (21%), Positives = 460/1014 (45%), Gaps = 138/1014 (13%)
Query: 462 LLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEK-ENQRLSKKVEILENEIVQEKQS 520
LL++ + + + EEL + +++ +ME ++Q +++K++ L+ ++ E +
Sbjct: 837 LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQ-LQEQLQAETEL 895
Query: 521 LQNCQNLSKDLMKEKAQLEK---TIETLRENSERQIKILEQENEHLNQTVSSLR------ 571
+ L L +K +LE+ +E E E + + L+ E + + Q + L
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEE 955
Query: 572 -------QRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKG 624
Q +++ EA++K +E+E IL ++ + KL+K EK+ ++ + +
Sbjct: 956 ESARQKLQLEKVTTEAKLKKLEEEQIIL----EDQNCKLAK---EKKLLEDRIAEFTTNL 1008
Query: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK----KTLD 680
EE L L+ ++E + IT+L+ E++ E++ ELE+ RKL+ D
Sbjct: 1009 TEEEEKSKSLAKLKNKHEAM---ITDLE---ERLRREEKQRQELEKTRRKLEGDSTDLSD 1062
Query: 681 SFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKG 740
L Q+ L+ + ++ +EE VE + A MA ++ +ELES+ +L++
Sbjct: 1063 QIAELQAQIAELKMQLAKKEEELQAALARVEE-EAAQKNMALKKI--RELESQISELQED 1119
Query: 741 LELLKASFKKTERLEVSY-QGLDIENQRLQKTLENS-------NKKIQQLESELQDLEME 792
LE +AS K E+ + + L+ L+ TL+++ +K+ Q++ + LE E
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179
Query: 793 NQTLQKNLEELKIS--------SKRLEQ-------LEKENKSLEQETSQLEKDKKQL--- 834
+T + ++E++ +++LEQ LEK ++LE E +L + K L
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQG 1239
Query: 835 --EKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEI------GIYKESCVRLKEL 886
+ E+KR + +A++++ ++ N + E +K ++ G+ +S + +L
Sbjct: 1240 KGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKL 1299
Query: 887 EK----------ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK-I 935
K + +EL++ +L T + + EK ++ + E+ H LEK I
Sbjct: 1300 TKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQI 1359
Query: 936 GLNKERLLHDEQSTDDRYKLLES------KLESTLKKSLEIKEEKIAALEARLEESTNYN 989
++ ++ +D LE+ KL+ L+ + EEK+AA + + T
Sbjct: 1360 ATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQ 1419
Query: 990 QQL----------RQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
Q+L RQ ++K + Q EE+ + S + E ++ E E++E +
Sbjct: 1420 QELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI--SAKYAEERDRAEAEAREKETK 1477
Query: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
L + L E A L+ + +T+++ L + +++ + L++ +L++Q +
Sbjct: 1478 ALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEM 1537
Query: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
+TQ +L+ E L + + + L ++ E + + ++ E+ K L++
Sbjct: 1538 KTQLEELEDE---LQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK---QLVRQV 1591
Query: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVE----HRDLEDRYNQLLKQKGQLEDLE 1215
++E E + + ++ L+ K+LE +++ ++ QL K + Q++D
Sbjct: 1592 REMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCM 1651
Query: 1216 KML---KVEQEKMLLENKNHE----TVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHK 1268
+ L + +E++L + K +E ++ AE +L E Q +E + L +
Sbjct: 1652 RELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIA 1711
Query: 1269 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1328
N + E+ RLEA ++L+E+ ++ + +N++ + K NL+ +D
Sbjct: 1712 NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK-----KANLQ------ID 1760
Query: 1329 QIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLN-ELRRQKEKLEEKIMDQYK 1381
QI T + R+ ++N + RQ +++ N EL+ + +++E + +YK
Sbjct: 1761 QINTDLNLERSHAQKNENA--------RQQLERQNKELKVKLQEMEGTVKSKYK 1806
Score = 157 bits (397), Expect = 9e-38
Identities = 202/981 (20%), Positives = 435/981 (44%), Gaps = 120/981 (12%)
Query: 432 ELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNAS 491
E E +++ EL + +K L E N LT L+ ++ + L + E+L+ +
Sbjct: 844 EEEMMAKEEELVKVREKQLAAE-NRLTEMETLQSQLMAEKL-QLQEQLQAETELCAEAEE 901
Query: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
++ + Q L + LE + +E++ Q+ Q EK ++++ I+ L E E
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEEEERCQHLQ-------AEKKKMQQNIQELEEQLE- 953
Query: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
E E Q + Q +++ EA++K +E+E IL + + KL+K EK+
Sbjct: 954 -------EEESARQKL----QLEKVTTEAKLKKLEEEQIILEDQ----NCKLAK---EKK 995
Query: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
++ + + EE L L+ ++E + IT+L+ E++ E++ ELE+
Sbjct: 996 LLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAM---ITDLE---ERLRREEKQRQELEKT 1049
Query: 672 NRKLK----KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
RKL+ D L Q+ L+ + ++ +EE VE + A MA ++
Sbjct: 1050 RRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEE-EAAQKNMALKKI-- 1106
Query: 728 KELESEKEQLKKGLELLKASFKKTERLEVSY-QGLDIENQRLQKTLENS-------NKKI 779
+ELES+ +L++ LE +AS K E+ + + L+ L+ TL+++ +K+
Sbjct: 1107 RELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE 1166
Query: 780 QQLESELQDLEMENQTLQKNLEELKIS-SKRLEQLEKENKSLEQETSQLEKDKKQLEKEN 838
Q++ + LE E +T + ++E++ S+ +E+L ++ + ++ + LEK K+ LE E
Sbjct: 1167 QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENER 1226
Query: 839 KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRAT 898
L + ++ + G + E+K E + +E V+ E E+ EL + T
Sbjct: 1227 GELANEVKV---------LLQGKGDSEHKRKKVEAQL-QELQVKFNEGERVRTELADKVT 1276
Query: 899 -----IDIKTLVTLREDLVSEKLKTQ------QMNNDLEKLTHE-LEKIGLN-KERLLHD 945
+D T + + D S KL Q+ + E L E +K+ L+ K + + D
Sbjct: 1277 KLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVED 1336
Query: 946 EQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEA 1005
E+++ E + + L+K + ++A ++ ++E+S + + + ++K+ E
Sbjct: 1337 EKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEG 1396
Query: 1006 LKQRQDE-----ERMVQSSPPISGE------DNKWERESQETTRELLKVKDRLIEVERNN 1054
L QR +E +++ ++ + E D +R+S + K D+L+ E+
Sbjct: 1397 LSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTI 1456
Query: 1055 ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLN 1114
+ AE++ + E + + + L+L R EQ L+ N + + E L
Sbjct: 1457 SAKYAEER------DRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM 1510
Query: 1115 SQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYE 1174
S + +L + +LE + E + + E+L+ + +LE+ + +++E
Sbjct: 1511 SSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFE 1570
Query: 1175 SLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHET 1234
++L+ E++ QL++Q + ++E L+ E+++ + +
Sbjct: 1571 -------------RDLQGRDEQSEEKKKQLVRQ---VREMEAELEDERKQRSMAVAARKK 1614
Query: 1235 VAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1294
+ + K L D N + +K+ LQ K+ L++++ + + A+ + +++
Sbjct: 1615 LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKK 1674
Query: 1295 YQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVE 1354
+ ++ +L + + K ++E L D+I N K +E
Sbjct: 1675 LKSMEAEMIQLQEELAAAERAKRQAQQERDELADEI------------ANSSGKGALALE 1722
Query: 1355 QRQYIDKLNELRRQKEKLEEK 1375
+++ ++ + + +E+LEE+
Sbjct: 1723 EKRRLEA--RIAQLEEELEEE 1741
Score = 124 bits (310), Expect = 1e-27
Identities = 147/710 (20%), Positives = 315/710 (44%), Gaps = 73/710 (10%)
Query: 247 QHLSVELADAKAKIR-------RLRQELEEKTEQLLDCKQELE-QMEIELKRLQQENMNL 298
+ + ELAD K++ L + + K+ +L LE Q++ + LQ+EN
Sbjct: 1265 ERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQK 1324
Query: 299 LSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELK---EDNQV 355
LS + + DE ++ RE+ ++ + + + LH A+V ++K ED+
Sbjct: 1325 LSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH------AQVADMKKKMEDSVG 1378
Query: 356 LLET----KTMLEDQLEGTRARSDK----LHELEKENLQLKAKLHDMEMERDMDRKKIEE 407
LET K L+ LEG R ++ +LEK +L+ +L D+ ++ D R+
Sbjct: 1379 CLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACN 1438
Query: 408 LMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
L ++ + + S E ++ + E SL + E + +LE
Sbjct: 1439 LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKA-ELER 1497
Query: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
N+ +E+L ++ D V + ++EK + L ++VE ++ ++ + + LQ ++
Sbjct: 1498 LNKQFRTEMEDLMSSKDDV---GKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDA 1554
Query: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
K +LE ++ ++ ER ++ ++++E ++ Q+ + R + E
Sbjct: 1555 -------KLRLEVNLQAMKAQFERDLQGRDEQSEE---------KKKQLVRQVREMEAEL 1598
Query: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 647
E++ S+ + K K+E + + ++ H + +E +L L+ + + ++
Sbjct: 1599 EDERKQRSMAVAARK--KLEMDLKDLEA---HIDSANKNRDEAIKQLRKLQAQMKDCMRE 1653
Query: 648 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELR 707
+ + + + E+I A +EN +KLK L +L + E+ Q +E EL
Sbjct: 1654 LDDTRASREEILAQAKENE------KKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQR 767
+ + +S K A E + LE+ QL++ LE + + TE + + +++ +
Sbjct: 1708 DEIAN---SSGKGALALEEKRRLEARIAQLEEELEEEQGN---TELINDRLKKANLQIDQ 1761
Query: 768 LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK--ISSKRLEQLEKENKSLEQETS 825
+ L Q+ E+ Q LE +N+ L+ L+E++ + SK + + Q
Sbjct: 1762 INTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEE 1821
Query: 826 QLEKDKKQLEKENKRLRQ-QAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884
QL+ + K+ + K++R+ + ++KD L+ ++ E+ N K+ ++ RLK
Sbjct: 1822 QLDNETKERQAACKQVRRTEKKLKDVLLQVDD------ERRNAEQYKDQA--DKASTRLK 1873
Query: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
+L+++ +E + A + L+ +L MN ++ L ++L +
Sbjct: 1874 QLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRR 1923
Score = 60.1 bits (144), Expect = 2e-08
Identities = 97/424 (22%), Positives = 180/424 (42%), Gaps = 77/424 (18%)
Query: 1038 RELLKVKDRLIEVERNNATLQA-EKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQN 1096
R KVK L++V R + A E++ +K + KQL +N + +
Sbjct: 829 RLFTKVKP-LLQVSRQEEEMMAKEEELVKVREKQLAAENRLTEME--------------- 872
Query: 1097 TTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLI 1156
TLQ+Q LM + QL Q L+ E E + E E+L++ +
Sbjct: 873 -TLQSQ-----------------LMAEKLQL---QEQLQAETE-LCAEAEELRARLTA-- 908
Query: 1157 KDHEKLELLHERQAS-EYESLISKHGTLKSAHKNLEVEHRDLEDRY--NQLLKQKGQLED 1213
K E E+ H+ +A E E +H L++ K ++ ++LE++ + +QK QLE
Sbjct: 909 KKQELEEICHDLEARVEEEEERCQH--LQAEKKKMQQNIQELEEQLEEEESARQKLQLEK 966
Query: 1214 L---EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNL 1270
+ K+ K+E+E+++LE++N + A+ KKL DR+ + L +E E K+L
Sbjct: 967 VTTEAKLKKLEEEQIILEDQNCK--LAKEKKLL--EDRIAEFTTNLTEEEE----KSKSL 1018
Query: 1271 KSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQI 1330
L N + T LE + ++Q Q+L+ T KL LS L+ + + ++
Sbjct: 1019 AKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQ----IAEL 1074
Query: 1331 QTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRR 1390
+ + + L+ + + ++ + K+ EL Q +L+E + +
Sbjct: 1075 KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESE----------- 1123
Query: 1391 RGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLE 1450
K K K+D+ E + T DS+ +L + Q+ + + E
Sbjct: 1124 -----RASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEE 1178
Query: 1451 DGQT 1454
+ +T
Sbjct: 1179 EAKT 1182
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 180 bits (457), Expect = 1e-44
Identities = 262/1267 (20%), Positives = 527/1267 (41%), Gaps = 150/1267 (11%)
Query: 249 LSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL---LSDARSA 305
LSV+L A +I+RL+++ ++ +Q +++ +MEI++K L Q+ L L +AR
Sbjct: 454 LSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGN 513
Query: 306 RMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLED 365
+ RDE + +++S E + +EEL++ NQ LL L +
Sbjct: 514 HVIRDE-----------EVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGE 562
Query: 366 --QLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSM 423
+ E S K+ EL+ + +L + R + ++ ++ + + Q+
Sbjct: 563 TREREEQETTSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTT 622
Query: 424 DESLHL-GWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTT 482
++ L L+ +S L+ P++ + S T +
Sbjct: 623 GVAIPLHASSLDDVS----LASTPKR-------------------PSTSQTVSTPAPVPV 659
Query: 483 VDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI 542
++S E +K + + + K E ENE +Q +Q L+ Q DL + + I
Sbjct: 660 IESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQ-LEKLQEQVTDLRSQNTK----I 714
Query: 543 ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSK 602
T + + ++ ++L+ E + ++SL +R+Q A + E+ + + ++ + K
Sbjct: 715 STQLDFASKRYEMLQDNVEGYRREITSLHERNQ-KLTATTQKQEQIINTMTQDLRGANEK 773
Query: 603 LSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEA-- 660
L+ E +KKE E K R + L ++ LL + ++ E+ E
Sbjct: 774 LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETET 833
Query: 661 ---LEQENSELERENRKLKKTLDS--------FKNLTFQLESLEKENSQLD-EENLELRR 708
L + +LE E LKK L++ +NL QL ++ QLD E NL L
Sbjct: 834 KQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKR---QLDTETNLHLNT 890
Query: 709 NVESLKCASMKMAQLQ--LENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
E LK A ++A L+ L N E++ + ++ + ++ + + L + + +
Sbjct: 891 K-ELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVN 949
Query: 767 RLQKTLENSNKKIQQ-------LESELQDLEMENQTLQKNLE-ELKISSKRLEQLEKENK 818
L++ L+ S ++Q LE L + + ++KN+E LK S++ QLEK+
Sbjct: 950 DLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLM 1009
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKE----IG 874
+E+E +L+ DK++ + + +Q +E+K T N L++ + LS E
Sbjct: 1010 EVEKEKQELQDDKRRAIESME--QQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRD 1067
Query: 875 IYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
+++ + ++ K +EL+ A D++ L +E + Q + +K +L +
Sbjct: 1068 CQEQAKIAVEAQNKYERELMLHAA-DVEALQAAKEQVSKMASVRQHLEETTQKAESQLLE 1126
Query: 935 IGLN---KERLLHDE--------QSTDDRYKLLESKLESTLKKSL-EIKEEKIAALEARL 982
+ +ER+L DE + + + +LL ++E K + +KE L L
Sbjct: 1127 CKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSL 1186
Query: 983 EESTNYNQQLRQELKTVKK------------NYEALKQRQDEERMVQSSPPISGEDNKWE 1030
E +Q+ + L+ +++ E+L+ RQ E + + + N
Sbjct: 1187 SEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERELQELQDSLNAER 1246
Query: 1031 RESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTV 1090
+ Q T + + + ++ + + E N ++ K L+ + ++LE +QA++ L+ +
Sbjct: 1247 EKVQVTAKTMAQHEELMKKTETMNVVMETNKM-LREEKERLEQDLQQMQAKVRKLELDIL 1305
Query: 1091 SLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENEN-ESVIKEREDLK 1149
LQE N L ++ LQ E L +N L+ QQ + E ++ E+E
Sbjct: 1306 PLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHT 1365
Query: 1150 SLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNL-------EVEHRDLEDRYN 1202
L E++ L A SL + ++S ++L E +DL+ +
Sbjct: 1366 KRIQQLT---EEIGRLKAEIARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKII 1422
Query: 1203 QLLKQKGQLEDLEKM----------LKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHT 1252
+ ++ + ++K+ LK +Q+K++ + E E L T
Sbjct: 1423 DIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKET 1482
Query: 1253 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1312
+Q +++ L++ +NL+ L+ + E L+ + +L+ + +L Q E L
Sbjct: 1483 LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQDLQDRTTQEEQL 1542
Query: 1313 SQLKGNLEEENR-----------HLLDQIQTLMLQNRTLLEQN---MESKDLFHVE---- 1354
Q EE+ R HL L +N L ++N + KD V
Sbjct: 1543 RQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQQKDELDVRITAL 1602
Query: 1355 QRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQ 1414
+ QY +++ L R+ + +E+ ++Q P+ N + + R++ + ER
Sbjct: 1603 KSQYEGRISRLERELREHQERHLEQ-----RDEPQEPSNKVPEQQRQITLKTTPASGERG 1657
Query: 1415 KSLTLTP 1421
+ T P
Sbjct: 1658 IASTSDP 1664
Score = 152 bits (383), Expect = 4e-36
Identities = 346/1679 (20%), Positives = 684/1679 (40%), Gaps = 291/1679 (17%)
Query: 223 FLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE 282
FL S G + ES Q + + + ++ ++ L +T + + ELE
Sbjct: 28 FLADQQSEIDGLKGRHEKFKVESEQ----QYFEIEKRLSHSQERLVNETRECQSLRLELE 83
Query: 283 QMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRV-DKLESE---VSRYKERL-H 337
++ +LK L ++N L + +D A++ + R ++LE+E + R ERL
Sbjct: 84 KLNNQLKALTEKNKEL-------EIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLSQ 136
Query: 338 DIEFYKARVEELKEDNQVLLETKTML-EDQLEGTRARSDKLHELEKENLQLKAKLHDMEM 396
++E+ E++K N+ L E+ T E QL KL EL+ ++ +K + +E
Sbjct: 137 ELEYL---TEDVKRLNEKLKESNTTKGELQL--------KLDELQASDVSVKYREKRLEQ 185
Query: 397 ERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE--APQKSLGHEV 454
E+++ L +N L K DE L LG E + +E+ E ++ EV
Sbjct: 186 EKEL-------LHSQNTWLNTELKTKTDELLALGRE-----KGNEILELKCNLENKKEEV 233
Query: 455 NELTSSRLLKLEMENQSLTKTVEELRTTV-DSVEGNASKILKMEKE---NQRLSKKVEIL 510
+ L ++ L+ N+ L K VE+L T + ++ E AS K E + +LS +
Sbjct: 234 SRL-EEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELNAHIKLSNLYKSA 292
Query: 511 ENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTI-------ETLRENSERQ----IKILEQE 559
++ + L L+KE + K I E ++ E++ I LE+E
Sbjct: 293 ADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKE 352
Query: 560 NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH 619
E+ N +S+ +++ I +E + ++ T++ ++KI
Sbjct: 353 LENANDLLSATKRKGAILSEEEL-----------AAMSPTAAAVAKI------------- 388
Query: 620 YKEKGERAEELENELHHLEKENELLQKKITNLKIT---CEKIEALEQENSELERENRKLK 676
+ G + EL N ++E +++LL +K+ N +I E ++ +E + L+R+ + +
Sbjct: 389 -VKPGMKLTELYNA--YVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYE 445
Query: 677 KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
+ + +L+ +LE KE +L E+ + A+ + + L+ +N+ +E + +
Sbjct: 446 RAQKAVASLSVKLEQAMKEIQRLQEDTDK----------ANKQSSVLERDNRRMEIQVKD 495
Query: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKI--QQLES--ELQDLEME 792
L + + +L ++ V I ++ + +S+ ++ Q L S +++L+ +
Sbjct: 496 LSQQIRVLLMELEEARGNHV------IRDEEVSSADISSSSEVISQHLVSYRNIEELQQQ 549
Query: 793 NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
NQ L L EL + +R EQ +K E + +LE +LE+ K + Q ++ D+ +
Sbjct: 550 NQRLLVALRELGETREREEQETTSSKITELQL-KLESALTELEQLRKSRQHQMQLVDSIV 608
Query: 853 EENNVKIGNLEKENKTLSKEIGIYKESC--VRLKELEK-----------------ENKEL 893
+ ++ L ++T I ++ S V L K E+ E
Sbjct: 609 RQRDMYRILL---SQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEA 665
Query: 894 VKRATIDIKTLVTLREDLVSEKLKTQQMNND-LEKLTHELEKIGLNKERLLHDEQSTDDR 952
++ A +K L + E+ EK + +++ N+ LEKL ++ + ++ R
Sbjct: 666 IE-AKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKISTQLDFASKR 724
Query: 953 YKLLESKLESTLKK--SLEIKEEKIAALEARLEESTN-YNQQLR---QELKTVKKNYEAL 1006
Y++L+ +E ++ SL + +K+ A + E+ N Q LR ++L + E L
Sbjct: 725 YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
Query: 1007 KQRQD-----EERMVQSSPPISGEDNKWE--RESQETTRELL-----KVKDRL-IEVERN 1053
K+ ++ E R+ Q + E + +T + +L + K RL ++E+
Sbjct: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKL 844
Query: 1054 NATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQN--AKLQVENS 1111
+ K+ L+ +++Q T NL Q+L +RQ + E N L T+ Q E +
Sbjct: 845 EHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDT--ETNLHLNTKELLKNAQKEIA 902
Query: 1112 TLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHER--- 1168
TL L N Q+ Q S + + +ED+ L L + E++ L ER
Sbjct: 903 TLKQH---LSNMEVQVASQSSQRTGKGQP--SNKEDVDDLVSQLRQTEEQVNDLKERLKT 957
Query: 1169 ---QASEYESLI-SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEK 1224
+Y++++ S +L + E +++E R + + + QLE +K+++VE+EK
Sbjct: 958 STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLE--KKLMEVEKEK 1015
Query: 1225 MLLENKNHETVAAEYKKLCGENDRL----NHTYSQLLKETEVLQTDHKNLKSLLNNSKL- 1279
L++ + + ++L L N L + + L + + + +K+
Sbjct: 1016 QELQDDKRRAIESMEQQLSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIA 1075
Query: 1280 --EQTRLEAEF-----------------SKLKEQYQQLDITSTKLNNQCELLSQLKGNLE 1320
Q + E E SK+ Q L+ T+ K +Q L + K + E
Sbjct: 1076 VEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEETTQKAESQ---LLECKASWE 1132
Query: 1321 EENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQY 1380
E R L D++ + + L +QN L Q EKL +K++
Sbjct: 1133 ERERMLKDEVSKCVCRCEDLEKQN------------------RLLHDQIEKLSDKVVASV 1174
Query: 1381 KFYDPSP------PRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLP 1434
K P + L++ + I+ +K+I R + + R L+
Sbjct: 1175 KEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELLERE 1234
Query: 1435 HQDSQDSSS-------VGSNSLEDGQTLGTKKSSM-VALKRLPFLRNR----PKDKDKMK 1482
Q+ QDS + V + ++ + L K +M V ++ LR +D +M+
Sbjct: 1235 LQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQ 1294
Query: 1483 ACYRR-SMSMNDLVQSMVLAGQWTG--STENLEVPDDISTGKRRKELGAMAFSTTAINFS 1539
A R+ + + L ++ + +G E + +D+ K R +
Sbjct: 1295 AKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQ-------------- 1340
Query: 1540 TVNSSAGFRSKQLVNNKDTTSFEDISPQGVSDDSSTGSRVHASRPASL--DSGRTSTSNS 1597
S+Q + DT + + + VH R L + GR +
Sbjct: 1341 ------HLVSQQ--KDPDTEEYRKLLSE---------KEVHTKRIQQLTEEIGRLKAEIA 1383
Query: 1598 NNNASLHEVKAGAVNNQSRPQSHSSGEFSLLHDHEAWSSSGSSPIQYLKRQTRSSPVLQH 1657
+NASL NNQ+ QS + + E + I ++ + ++ ++
Sbjct: 1384 RSNASL-------TNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVK- 1435
Query: 1658 KISETLESRHHKIK-------------TGSPGSEVVTLQQFLEESNKLTSVQIKSSSQEN 1704
KI ++++ ++K +G + V++Q+ E L + KS S E+
Sbjct: 1436 KIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLES 1495
Query: 1705 LLDEVMKSLSVSSDFLGKDKPVSCGLARSVSGKTPGDFYDRRTTKPEFLRPGPRKTEDT 1763
++ + K+LS + + L +S + D DR T + + + K E T
Sbjct: 1496 QVENLQKTLSEKETEARNLQEQTVQLQSELS-RLRQDLQDRTTQEEQLRQQITEKEEKT 1553
Score = 145 bits (365), Expect = 5e-34
Identities = 236/1129 (20%), Positives = 473/1129 (41%), Gaps = 158/1129 (13%)
Query: 404 KIEELMEENMTLEMAQKQSMDESL---HLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
K+ + ++ + +A +QS + L H +++E + E+ + S VNE
Sbjct: 16 KLPKSVQNKLEKFLADQQSEIDGLKGRHEKFKVESEQQYFEIEKRLSHSQERLVNETREC 75
Query: 461 RLLKLEMEN-----QSLTKTVEELRTTVDSVEGNASKILKMEKE-----------NQRLS 504
+ L+LE+E ++LT+ +EL D S+ + ++E N+RLS
Sbjct: 76 QSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKEELEAEKRDLIRTNERLS 135
Query: 505 KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564
+++E L ++ + + L+ +L + +L+ + +++ +R LEQE E L+
Sbjct: 136 QELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVKYREKR----LEQEKELLH 191
Query: 565 QTVSSLRQRSQISA-EARVKDIEKENKILHE--SIKETSSKLSKIEFEKRQIKKELEHY- 620
+ L + E EK N+IL +++ ++S++E + +K EH
Sbjct: 192 SQNTWLNTELKTKTDELLALGREKGNEILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQ 251
Query: 621 ----------KEKGERAEELENELHHLEKENEL-LQKKITNL-KITCEKIEALEQENSEL 668
KE E+ +E + H NEL K++NL K + EA E +
Sbjct: 252 KHVEDLLTKLKEAKEQQASMEEKFH-----NELNAHIKLSNLYKSAADDSEAKSNELTRA 306
Query: 669 ERENRKL-KKTLDSFKNLTFQLESLEKENSQLDEENLE----LRRNVESLK--CASMKMA 721
E KL K+ ++ K + L +E+ Q+++E LE L + +E+ ++ K
Sbjct: 307 VEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRK 366
Query: 722 QLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLD------IENQRLQKTLENS 775
L +EL + +++K K TE + D +EN+R+ K L+
Sbjct: 367 GAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEI 426
Query: 776 NKKIQQLESELQDLEMENQTLQKNLEELKI----SSKRLEQLEKENKSLEQETSQLEKDK 831
K+++ L+ E + QK + L + + K +++L+++ +++S LE+D
Sbjct: 427 VKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDN 486
Query: 832 KQLEKENKRLRQQAEIKDTTLEE---------NNVKIGNLEKENKTLSKEIGIYKESCVR 882
+++E + K L QQ + LEE V ++ ++ +S+ + Y+
Sbjct: 487 RRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQHLVSYR----N 542
Query: 883 LKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERL 942
++EL+++N+ L+ +T ++ S K+ Q+ LE ELE++ +++
Sbjct: 543 IEELQQQNQRLLVALRELGETREREEQETTSSKITELQLK--LESALTELEQLRKSRQ-- 598
Query: 943 LHDEQSTD------DRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQEL 996
H Q D D Y++L S+ + ++ ST+ +
Sbjct: 599 -HQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPV 657
Query: 997 KTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT 1056
++ EA++ + +++ + E+ K E+ E + ++L +++
Sbjct: 658 PVIEST-EAIEAKAALKQLQEIF-----ENYKKEKAENEKIQ-----NEQLEKLQEQVTD 706
Query: 1057 LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
L+++ + TQL + LQ + +R+ SL E+N Q A Q + +N+
Sbjct: 707 LRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERN---QKLTATTQKQEQIINTM 763
Query: 1117 STSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESL 1176
+ L N +L + + EN L K+ E L+L R + + ESL
Sbjct: 764 TQDLRGANEKLAVAEVRAEN------------------LKKEKEMLKLSEVRLSQQRESL 805
Query: 1177 ISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK--GQLEDLEKMLKVEQEKMLLENKNHET 1234
+++ NL+ LE R KQ+ Q+E LE + ++K+ E + T
Sbjct: 806 LAEQRGQNLLLTNLQTIQGILE-RSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHT 864
Query: 1235 VAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQ 1294
+ + +L T QL ET + H N K LL N++ E L+ S ++ Q
Sbjct: 865 LTRNL------DVQLLDTKRQLDTETNL----HLNTKELLKNAQKEIATLKQHLSNMEVQ 914
Query: 1295 Y----------------QQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNR 1338
+ +D ++L E ++ LK L+ + ++Q Q ++
Sbjct: 915 VASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSN-VEQYQAMV---- 969
Query: 1339 TLLEQNMESKDLFHVEQRQYID-KLNELRRQKEKLEEKIMDQYKFYD--PSPPRRRGNWI 1395
T LE+++ + E R+ I+ +L E + +LE+K+M+ K RR +
Sbjct: 970 TSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESM 1029
Query: 1396 TLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSV 1444
++ +L K+ + E Q++L T + Q +D Q+ + +
Sbjct: 1030 EQQLSELKKTLSSVQNEVQEALQRASTALSNE----QQARRDCQEQAKI 1074
Score = 127 bits (318), Expect = 1e-28
Identities = 190/929 (20%), Positives = 404/929 (43%), Gaps = 136/929 (14%)
Query: 164 THNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHF 223
T QE + + ++ +++ L + + L E++ + + LS++R+ L
Sbjct: 753 TQKQEQIINTMTQDLRGANEK-----LAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLA 807
Query: 224 LPHASS----SAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQ------ 273
+ + Q+ G TE++Q LS ++ + +I L+++LE + EQ
Sbjct: 808 EQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTR 867
Query: 274 -----LLDCKQELE----------------QMEIELKRLQQENMNLL----SDARSARMY 308
LLD K++L+ Q EI + NM + S R+ +
Sbjct: 868 NLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQ 927
Query: 309 RDELDALREKAVRVDKLESEVSRYKERLH----DIEFYKARV----EELKEDNQVLLETK 360
+ + + ++ + E +V+ KERL ++E Y+A V E L ++ QV E +
Sbjct: 928 PSNKEDVDDLVSQLRQTEEQVNDLKERLKTSTSNVEQYQAMVTSLEESLNKEKQVTEEVR 987
Query: 361 TMLEDQL----EGTRARSDKLHELEKENLQL----KAKLHDMEMERDMDRKKIEELMEE- 411
+E +L E KL E+EKE +L + + ME + +K + + E
Sbjct: 988 KNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELKKTLSSVQNEV 1047
Query: 412 ---------NMTLEMAQKQSMDESLHLGWELE-QISRTSELSEAPQKSLG---HEVNELT 458
++ E ++ E + E + + R L A ++L +V+++
Sbjct: 1048 QEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMA 1107
Query: 459 SSRLLKLEMENQSLTKTVE-------ELRTTVDSVEGNASKILKMEKENQRLSKKVEILE 511
S R E ++ ++ +E R D V + +EK+N+ L ++E L
Sbjct: 1108 SVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLEKQNRLLHDQIEKLS 1167
Query: 512 NEIVQE-KQSLQNCQNLS---------------KDLMKEKAQLEKTIETLRENSER---Q 552
+++V K+ +Q N+S + + +EK E E + S R +
Sbjct: 1168 DKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQR 1227
Query: 553 IKILEQENEHLNQTVSSLRQRSQISAE--ARVKDIEKENKILHESIKETSSKLSKIEFEK 610
+++LE+E + L ++++ R++ Q++A+ A+ +++ K+ + ++ + ET+ L + EK
Sbjct: 1228 VELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNV-VMETNKMLRE---EK 1283
Query: 611 RQIKKELEHYKEKGERAE-----------ELENELHHLEKENELLQKKITNLKITCEKIE 659
+++++L+ + K + E EL + L+ E +LL++ + K + +
Sbjct: 1284 ERLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLV 1343
Query: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK 719
+ +Q++ + E + L + K + E + + +++ N L N ++
Sbjct: 1344 S-QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKED 1402
Query: 720 MAQLQLEN----KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENS 775
+ +++ E K+L+++ +++ ++ + K R + Y+ L + ++ +T S
Sbjct: 1403 LNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQS 1462
Query: 776 NKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE 835
+ Q+ +Q+++ +TL + + K ++E L+K E E L++ QL+
Sbjct: 1463 SGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQ 1522
Query: 836 KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL----KELEKENK 891
E RLRQ +++D T +E ++ EKE KT K I K L +L KEN+
Sbjct: 1523 SELSRLRQ--DLQDRTTQEEQLRQQITEKEEKT-RKAIVAAKSKIAHLAGVKDQLTKENE 1579
Query: 892 ELVKRATIDIKTLVTLREDLVSEKLKT--QQMNNDLEKLTHELEKIGLNKERLLHD-EQS 948
EL +R + ++D + ++ Q + +L EL + ++ER L ++
Sbjct: 1580 ELKQR-----NGALDQQKDELDVRITALKSQYEGRISRLERELRE---HQERHLEQRDEP 1631
Query: 949 TDDRYKLLESKLESTLKKSLEIKEEKIAA 977
+ K+ E + + TLK + E IA+
Sbjct: 1632 QEPSNKVPEQQRQITLKTTPASGERGIAS 1660
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 179 bits (453), Expect = 3e-44
Identities = 271/1296 (20%), Positives = 536/1296 (41%), Gaps = 116/1296 (8%)
Query: 115 EQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ 174
+Q EE ++L + Q Q E + + + K +EV +E D Q
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1412
Query: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
+ + QE+++ L ++ ++ + + + + + EE + A+ +
Sbjct: 1413 QQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG- 1469
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
G+ G Q L +A+A+ R+ ++E E Q+ D Q Q E+EL
Sbjct: 1470 -GAEG-----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---- 1519
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
+ ++A +AR + L AL E ++ ++ E RL E +AR Q
Sbjct: 1520 --RVKAEAEAAREKQRALQALEELRLQAEEAE-------RRLRQAEVERAR------QVQ 1564
Query: 355 VLLET-KTMLEDQLEGTRAR-SDKLHELEK---ENLQLKAKLHDMEMERDMDRKKIEELM 409
V LET + E +L+ RA ++K +LE+ E A+L + R + + E
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 410 EE-NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE LE Q ++ +E+L L + E++++ L++A + E R E
Sbjct: 1625 EEAERELERWQLKA-NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE-------ILENEIVQEKQ-- 519
+ +EL EG A + L E+E RL + E +LE E+ + ++
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 520 --SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ Q Q L +L K +A++E + + E E+ + L R+ ++ +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 578 AEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELEN 632
A R ++ +++ ++ E ++ ++ EK E K + E A +E EN
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS-FKNLTFQLES 691
E E+E Q++ E Q +++E +L+K DS + +E
Sbjct: 1864 ERLRRLAEDEAFQRRRLE--------EQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
++ Q++EE L L+ + E A+ A+L+LE + S E + E + +
Sbjct: 1916 TLRQRRQVEEEILALKASFEK---AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 752 ERLEVSYQGLDIE-NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
+L + E +R+QK+L + +Q ++ L+++E L+ +EE + +R
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARRLRERA 2028
Query: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKR----LRQQAEIKDTTLEENNVKIGNLEKEN 866
EQ L QE +Q K+L+ E K ++Q+ + TL++ + L E
Sbjct: 2029 EQESARQLQLAQEAAQ-----KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
+ + +E+ V+ + +++ V+ A L++ + Q E
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSAEEQAQARAQAQAAAE 2136
Query: 927 KLTHELEKIGLNK----ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
KL E E+ + + L +Q+ D + + E TL++ ++++E + L +L
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQL 2195
Query: 983 EESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041
EE+ + L +EL+ +K EA +QR E + S E +K + + R L+
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 1042 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1101
L + + LQ E + +K + E ++ AQ A RQ L E++ Q
Sbjct: 2256 -----LRDKDNTQRFLQEEAEKMKQVAE--EAARLSVAAQEAARLRQ---LAEEDLAQQR 2305
Query: 1102 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1161
A+ ++ Q + + A+LL QQ L E ++E D + + L ++ +
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQG 2363
Query: 1162 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-EDLEKMLKV 1220
+ E + + ++ LK + E+ + KQ ++ E L +
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 1221 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1280
QEK+ L +T+ + ++ + +RL ++L +E E LQ + K L+ L + +++
Sbjct: 2424 TQEKVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQ 2477
Query: 1281 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL 1340
+ E + Q+ ++ + L Q + +E+E L Q + + + L
Sbjct: 2478 TVQQE-------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530
Query: 1341 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
E+ + E+++ + + E RR++ + EE +
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Score = 149 bits (376), Expect = 2e-35
Identities = 263/1251 (21%), Positives = 502/1251 (40%), Gaps = 183/1251 (14%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA-----RSAR 306
EL KA +++LR + E + + EL + +RLQQ + + R A+
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183
Query: 307 MYRDELDALREKAVRVDKLES---EVSRYKERLHDIEFY----KARVEELK----EDNQV 355
+ L + VR +LE ++ Y+E + + + R E+++ D+Q
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME--ENM 413
+ E + LE +K+ E ++ Q + D E++ + ++E + +
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 414 TLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
++ + + E + L +++ TS+ + ++L E + + E E + L
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1362
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
+ L E +A + E+E + L ++ ++ E+V+ +++ + Q + +
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR---MQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAE------- 579
+E QL ++ E + RQ + E+ + + + +R +R + AE
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638
AR ++ E + + E + ++ KRQ + EL K + E A E + L LE
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD----SFKNLTFQLE-SLE 693
+ LQ + ++ ++E Q LE R + L SF T QLE SL+
Sbjct: 1540 ELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 694 KEN---SQLDEE-----------------------------NLELRRNVESLKCASMK-M 720
+E+ +QL EE N LR +++ + A K +
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ-------------- 766
AQ + E ++ E+E+E ++G KA + + E++ Q L+ + Q
Sbjct: 1658 AQAEAEKQKEEAEREARRRG----KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 767 ---RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL-----KISSKRLEQLEKENK 818
RL+ E ++ Q LE EL L+ E + +EL K+ ++ L + +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE------------IKDTTLEENNVKIGNLEKEN 866
+ E+ S EK K++LE E R R+ AE + L E + E E
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1833
Query: 867 KTLSKEIGIYK------ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
K I + E+ + LKE E EN+ L + A + L E K
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---- 1889
Query: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980
D+E ERL +++D + + +E TL++ ++ EE+I AL+A
Sbjct: 1890 ---DIE-------------ERLAQLRKASDSELERQKGLVEDTLRQRRQV-EEEILALKA 1932
Query: 981 RLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
E++ +L EL ++ N E L+ ++ E ++ E+ + RE++E ++
Sbjct: 1933 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
L ++ E R E + LK +++ +A+ L + + S ++
Sbjct: 1993 SLAAEE---EAARQRKAALEEVERLKAKVE---------EARRLRERAEQESARQLQLAQ 2040
Query: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
+ +LQ E ++ + Q Q +QQ +SV+ + ++
Sbjct: 2041 EAAQKRLQAEEKA-HAFAVQQKEQELQQTLQQ------EQSVLDQLRGEAEAARRAAEEA 2093
Query: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
E+ + ER+A++ + + LK + + + +L K+ Q E +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ----EAARR 2149
Query: 1220 VEQEKMLLENKNHETVAAE-YKKLCGENDRLNHTYSQLLK--ETEVLQTDHKNLKSLLNN 1276
+ E+ L K E +KK + R Q L ++ +TDH+ K+LL+
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ--KNLLDE 2207
Query: 1277 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL----DQIQT 1332
E RL+AE ++ Q Q++ + Q E LS+LK +E ENR L+ D Q
Sbjct: 2208 ---ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 1333 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR----QKEKLEEKIMDQ 1379
+ + ++Q E V Q +L +L Q+ L EK++ +
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Score = 139 bits (351), Expect = 2e-32
Identities = 197/954 (20%), Positives = 413/954 (43%), Gaps = 127/954 (13%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
T+ ++ + L + +A + + E EL++ R + L + + A+ S
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 239 GMK---RTESRQHLSVELADAKAKIRRLRQE----------------------LEEKTEQ 273
K R E+ ELA+ A++R L +E L EK
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 274 LLDCKQELEQMEIELKRLQQENMNL--LSDARSARMYRDELDALREKAVRVDKL------ 325
+ + + + EI LK + EN L L++ + + R E A + KA ++L
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 326 -ESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARS-DKLHE 379
+SE+ R K + D + +VEE LK + K LE +L R+ + D L
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE----MAQKQSMDESLHLGWELEQ 435
E+ L+ A+ + E + R++ EE +++++ E +K +++E L ++E+
Sbjct: 1962 KEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 436 ISRTSELSEAPQKSLGHEVNELTSSRL--------LKLEMENQSLTKTVEELRTTVDSVE 487
R E +E E RL ++ + Q L +T+++ ++ +D +
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIET 544
G A + +E + + E E Q ++ ++ + L + ++ +AQ + E
Sbjct: 2081 GEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
LR+ +E++ Q + ++LRQ+ AE +EK K +++++ +
Sbjct: 2138 LRKEAEQEAARRAQAEQ------AALRQKQAADAE-----MEKHKKFAEQTLRQKAQVEQ 2186
Query: 605 KIEFEKRQIKKELEHYKEK-GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
++ + Q++ E +H K E + L+ E ++ +++++ ++++ E++ L+
Sbjct: 2187 ELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK- 2244
Query: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK-MAQ 722
+ +E ENR L D F E EK +E R +V + + A ++ +A+
Sbjct: 2245 --ARIEAENRALILR-DKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAE 2298
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
L + +EK LK+ ++ ++ + + E+ Q ++ ++ ++ E+ + QQL
Sbjct: 2299 EDLAQQRALAEK-MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
E Q + +TL+ + S E+L+ + + ++ E+D ++ K+ + +
Sbjct: 2358 AEETQGFQ---RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
++ + +E + LE + + + +E+ + ELE+E ++L + A +
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA---IAELEREKEKLQQEAKL--- 2468
Query: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
L SE+++T Q +E+LL + Q+ + S+ +S
Sbjct: 2469 ------LQLKSEEMQTVQ------------------QEQLLQETQALQQSFL---SEKDS 2501
Query: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1022
L++ I++EK A LE ++ QQLR+E + ++ E Q+ +R+V S
Sbjct: 2502 LLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQRQQQQME-----QERQRLVASME-- 2553
Query: 1023 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK-QALKTQLKQLETQN 1075
E + + E++E R + +L + R L AE+ Q L+ QL+ LE Q+
Sbjct: 2554 --EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Score = 47.8 bits (112), Expect = 1e-04
Identities = 46/209 (22%), Positives = 93/209 (44%), Gaps = 23/209 (11%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH----FLPHASSSAQSP 234
T+++ ++ L++ + + ++ + + E I EL E++ L L S Q+
Sbjct: 2420 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2479
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD-----CKQELEQMEIELK 289
++ T++ Q + D+ + R ++ + K EQL +Q E+ + + +
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539
Query: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
+++QE L++ AR + E E V R +E L +E + + EEL
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEA-------------EEGVRRKQEELQQLEQQRRQQEEL 2586
Query: 350 -KEDNQVLLETKTMLEDQLEGTRARSDKL 377
E+NQ L E +LE+Q A S+++
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEV 2615
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 179 bits (453), Expect = 3e-44
Identities = 271/1296 (20%), Positives = 536/1296 (41%), Gaps = 116/1296 (8%)
Query: 115 EQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ 174
+Q EE ++L + Q Q E + + + K +EV +E D Q
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1416
Query: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
+ + QE+++ L ++ ++ + + + + + EE + A+ +
Sbjct: 1417 QQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG- 1473
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
G+ G Q L +A+A+ R+ ++E E Q+ D Q Q E+EL
Sbjct: 1474 -GAEG-----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---- 1523
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
+ ++A +AR + L AL E ++ ++ E RL E +AR Q
Sbjct: 1524 --RVKAEAEAAREKQRALQALEELRLQAEEAE-------RRLRQAEVERAR------QVQ 1568
Query: 355 VLLET-KTMLEDQLEGTRAR-SDKLHELEK---ENLQLKAKLHDMEMERDMDRKKIEELM 409
V LET + E +L+ RA ++K +LE+ E A+L + R + + E
Sbjct: 1569 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1628
Query: 410 EE-NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE LE Q ++ +E+L L + E++++ L++A + E R E
Sbjct: 1629 EEAERELERWQLKA-NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1687
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE-------ILENEIVQEKQ-- 519
+ +EL EG A + L E+E RL + E +LE E+ + ++
Sbjct: 1688 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1747
Query: 520 --SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ Q Q L +L K +A++E + + E E+ + L R+ ++ +
Sbjct: 1748 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1807
Query: 578 AEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELEN 632
A R ++ +++ ++ E ++ ++ EK E K + E A +E EN
Sbjct: 1808 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1867
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS-FKNLTFQLES 691
E E+E Q++ E Q +++E +L+K DS + +E
Sbjct: 1868 ERLRRLAEDEAFQRRRLE--------EQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
++ Q++EE L L+ + E A+ A+L+LE + S E + E + +
Sbjct: 1920 TLRQRRQVEEEILALKASFEK---AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1976
Query: 752 ERLEVSYQGLDIE-NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
+L + E +R+QK+L + +Q ++ L+++E L+ +EE + +R
Sbjct: 1977 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARRLRERA 2032
Query: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKR----LRQQAEIKDTTLEENNVKIGNLEKEN 866
EQ L QE +Q K+L+ E K ++Q+ + TL++ + L E
Sbjct: 2033 EQESARQLQLAQEAAQ-----KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2087
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
+ + +E+ V+ + +++ V+ A L++ + Q E
Sbjct: 2088 EAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSAEEQAQARAQAQAAAE 2140
Query: 927 KLTHELEKIGLNK----ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
KL E E+ + + L +Q+ D + + E TL++ ++++E + L +L
Sbjct: 2141 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQL 2199
Query: 983 EESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041
EE+ + L +EL+ +K EA +QR E + S E +K + + R L+
Sbjct: 2200 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2259
Query: 1042 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1101
L + + LQ E + +K + E ++ AQ A RQ L E++ Q
Sbjct: 2260 -----LRDKDNTQRFLQEEAEKMKQVAE--EAARLSVAAQEAARLRQ---LAEEDLAQQR 2309
Query: 1102 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1161
A+ ++ Q + + A+LL QQ L E ++E D + + L ++ +
Sbjct: 2310 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQG 2367
Query: 1162 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-EDLEKMLKV 1220
+ E + + ++ LK + E+ + KQ ++ E L +
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2427
Query: 1221 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1280
QEK+ L +T+ + ++ + +RL ++L +E E LQ + K L+ L + +++
Sbjct: 2428 TQEKVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQ 2481
Query: 1281 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL 1340
+ E + Q+ ++ + L Q + +E+E L Q + + + L
Sbjct: 2482 TVQQE-------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2534
Query: 1341 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
E+ + E+++ + + E RR++ + EE +
Sbjct: 2535 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2570
Score = 149 bits (376), Expect = 2e-35
Identities = 263/1251 (21%), Positives = 502/1251 (40%), Gaps = 183/1251 (14%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA-----RSAR 306
EL KA +++LR + E + + EL + +RLQQ + + R A+
Sbjct: 1128 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1187
Query: 307 MYRDELDALREKAVRVDKLES---EVSRYKERLHDIEFY----KARVEELK----EDNQV 355
+ L + VR +LE ++ Y+E + + + R E+++ D+Q
Sbjct: 1188 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1247
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME--ENM 413
+ E + LE +K+ E ++ Q + D E++ + ++E + +
Sbjct: 1248 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1307
Query: 414 TLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
++ + + E + L +++ TS+ + ++L E + + E E + L
Sbjct: 1308 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1366
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
+ L E +A + E+E + L ++ ++ E+V+ +++ + Q + +
Sbjct: 1367 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR---MQEEVVRREEAAVDAQQQKRSIQ 1423
Query: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAE------- 579
+E QL ++ E + RQ + E+ + + + +R +R + AE
Sbjct: 1424 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1483
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638
AR ++ E + + E + ++ KRQ + EL K + E A E + L LE
Sbjct: 1484 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1543
Query: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD----SFKNLTFQLE-SLE 693
+ LQ + ++ ++E Q LE R + L SF T QLE SL+
Sbjct: 1544 ELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1601
Query: 694 KEN---SQLDEE-----------------------------NLELRRNVESLKCASMK-M 720
+E+ +QL EE N LR +++ + A K +
Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1661
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ-------------- 766
AQ + E ++ E+E+E ++G KA + + E++ Q L+ + Q
Sbjct: 1662 AQAEAEKQKEEAEREARRRG----KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1717
Query: 767 ---RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL-----KISSKRLEQLEKENK 818
RL+ E ++ Q LE EL L+ E + +EL K+ ++ L + +
Sbjct: 1718 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1777
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE------------IKDTTLEENNVKIGNLEKEN 866
+ E+ S EK K++LE E R R+ AE + L E + E E
Sbjct: 1778 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1837
Query: 867 KTLSKEIGIYK------ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
K I + E+ + LKE E EN+ L + A + L E K
Sbjct: 1838 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---- 1893
Query: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980
D+E ERL +++D + + +E TL++ ++ EE+I AL+A
Sbjct: 1894 ---DIE-------------ERLAQLRKASDSELERQKGLVEDTLRQRRQV-EEEILALKA 1936
Query: 981 RLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
E++ +L EL ++ N E L+ ++ E ++ E+ + RE++E ++
Sbjct: 1937 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1996
Query: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
L ++ E R E + LK +++ +A+ L + + S ++
Sbjct: 1997 SLAAEE---EAARQRKAALEEVERLKAKVE---------EARRLRERAEQESARQLQLAQ 2044
Query: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
+ +LQ E ++ + Q Q +QQ +SV+ + ++
Sbjct: 2045 EAAQKRLQAEEKA-HAFAVQQKEQELQQTLQQ------EQSVLDQLRGEAEAARRAAEEA 2097
Query: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
E+ + ER+A++ + + LK + + + +L K+ Q E +
Sbjct: 2098 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ----EAARR 2153
Query: 1220 VEQEKMLLENKNHETVAAE-YKKLCGENDRLNHTYSQLLK--ETEVLQTDHKNLKSLLNN 1276
+ E+ L K E +KK + R Q L ++ +TDH+ K+LL+
Sbjct: 2154 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ--KNLLDE 2211
Query: 1277 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL----DQIQT 1332
E RL+AE ++ Q Q++ + Q E LS+LK +E ENR L+ D Q
Sbjct: 2212 ---ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2268
Query: 1333 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR----QKEKLEEKIMDQ 1379
+ + ++Q E V Q +L +L Q+ L EK++ +
Sbjct: 2269 FLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQQRALAEKMLKE 2318
Score = 139 bits (351), Expect = 2e-32
Identities = 197/954 (20%), Positives = 413/954 (43%), Gaps = 127/954 (13%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
T+ ++ + L + +A + + E EL++ R + L + + A+ S
Sbjct: 1726 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1785
Query: 239 GMK---RTESRQHLSVELADAKAKIRRLRQE----------------------LEEKTEQ 273
K R E+ ELA+ A++R L +E L EK
Sbjct: 1786 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1845
Query: 274 LLDCKQELEQMEIELKRLQQENMNL--LSDARSARMYRDELDALREKAVRVDKL------ 325
+ + + + EI LK + EN L L++ + + R E A + KA ++L
Sbjct: 1846 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1905
Query: 326 -ESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARS-DKLHE 379
+SE+ R K + D + +VEE LK + K LE +L R+ + D L
Sbjct: 1906 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1965
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE----MAQKQSMDESLHLGWELEQ 435
E+ L+ A+ + E + R++ EE +++++ E +K +++E L ++E+
Sbjct: 1966 KEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2024
Query: 436 ISRTSELSEAPQKSLGHEVNELTSSRL--------LKLEMENQSLTKTVEELRTTVDSVE 487
R E +E E RL ++ + Q L +T+++ ++ +D +
Sbjct: 2025 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2084
Query: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIET 544
G A + +E + + E E Q ++ ++ + L + ++ +AQ + E
Sbjct: 2085 GEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
LR+ +E++ Q + ++LRQ+ AE +EK K +++++ +
Sbjct: 2142 LRKEAEQEAARRAQAEQ------AALRQKQAADAE-----MEKHKKFAEQTLRQKAQVEQ 2190
Query: 605 KIEFEKRQIKKELEHYKEK-GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
++ + Q++ E +H K E + L+ E ++ +++++ ++++ E++ L+
Sbjct: 2191 ELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK- 2248
Query: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK-MAQ 722
+ +E ENR L D F E EK +E R +V + + A ++ +A+
Sbjct: 2249 --ARIEAENRALILR-DKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAE 2302
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
L + +EK LK+ ++ ++ + + E+ Q ++ ++ ++ E+ + QQL
Sbjct: 2303 EDLAQQRALAEK-MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2361
Query: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
E Q + +TL+ + S E+L+ + + ++ E+D ++ K+ + +
Sbjct: 2362 AEETQGFQ---RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2418
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
++ + +E + LE + + + +E+ + ELE+E ++L + A +
Sbjct: 2419 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA---IAELEREKEKLQQEAKL--- 2472
Query: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
L SE+++T Q +E+LL + Q+ + S+ +S
Sbjct: 2473 ------LQLKSEEMQTVQ------------------QEQLLQETQALQQSFL---SEKDS 2505
Query: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1022
L++ I++EK A LE ++ QQLR+E + ++ E Q+ +R+V S
Sbjct: 2506 LLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQRQQQQME-----QERQRLVASME-- 2557
Query: 1023 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK-QALKTQLKQLETQN 1075
E + + E++E R + +L + R L AE+ Q L+ QL+ LE Q+
Sbjct: 2558 --EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2609
Score = 47.8 bits (112), Expect = 1e-04
Identities = 46/209 (22%), Positives = 93/209 (44%), Gaps = 23/209 (11%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH----FLPHASSSAQSP 234
T+++ ++ L++ + + ++ + + E I EL E++ L L S Q+
Sbjct: 2424 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2483
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD-----CKQELEQMEIELK 289
++ T++ Q + D+ + R ++ + K EQL +Q E+ + + +
Sbjct: 2484 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2543
Query: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
+++QE L++ AR + E E V R +E L +E + + EEL
Sbjct: 2544 QMEQERQRLVASMEEARRRQHEA-------------EEGVRRKQEELQQLEQQRRQQEEL 2590
Query: 350 -KEDNQVLLETKTMLEDQLEGTRARSDKL 377
E+NQ L E +LE+Q A S+++
Sbjct: 2591 LAEENQRLREQLQLLEEQHRAALAHSEEV 2619
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 179 bits (453), Expect = 3e-44
Identities = 271/1296 (20%), Positives = 536/1296 (41%), Gaps = 116/1296 (8%)
Query: 115 EQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ 174
+Q EE ++L + Q Q E + + + K +EV +E D Q
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1412
Query: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
+ + QE+++ L ++ ++ + + + + + EE + A+ +
Sbjct: 1413 QQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG- 1469
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
G+ G Q L +A+A+ R+ ++E E Q+ D Q Q E+EL
Sbjct: 1470 -GAEG-----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---- 1519
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
+ ++A +AR + L AL E ++ ++ E RL E +AR Q
Sbjct: 1520 --RVKAEAEAAREKQRALQALEELRLQAEEAE-------RRLRQAEVERAR------QVQ 1564
Query: 355 VLLET-KTMLEDQLEGTRAR-SDKLHELEK---ENLQLKAKLHDMEMERDMDRKKIEELM 409
V LET + E +L+ RA ++K +LE+ E A+L + R + + E
Sbjct: 1565 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1624
Query: 410 EE-NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE LE Q ++ +E+L L + E++++ L++A + E R E
Sbjct: 1625 EEAERELERWQLKA-NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1683
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE-------ILENEIVQEKQ-- 519
+ +EL EG A + L E+E RL + E +LE E+ + ++
Sbjct: 1684 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1743
Query: 520 --SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ Q Q L +L K +A++E + + E E+ + L R+ ++ +
Sbjct: 1744 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1803
Query: 578 AEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELEN 632
A R ++ +++ ++ E ++ ++ EK E K + E A +E EN
Sbjct: 1804 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1863
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS-FKNLTFQLES 691
E E+E Q++ E Q +++E +L+K DS + +E
Sbjct: 1864 ERLRRLAEDEAFQRRRLE--------EQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
++ Q++EE L L+ + E A+ A+L+LE + S E + E + +
Sbjct: 1916 TLRQRRQVEEEILALKASFEK---AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1972
Query: 752 ERLEVSYQGLDIE-NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
+L + E +R+QK+L + +Q ++ L+++E L+ +EE + +R
Sbjct: 1973 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARRLRERA 2028
Query: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKR----LRQQAEIKDTTLEENNVKIGNLEKEN 866
EQ L QE +Q K+L+ E K ++Q+ + TL++ + L E
Sbjct: 2029 EQESARQLQLAQEAAQ-----KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2083
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
+ + +E+ V+ + +++ V+ A L++ + Q E
Sbjct: 2084 EAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSAEEQAQARAQAQAAAE 2136
Query: 927 KLTHELEKIGLNK----ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
KL E E+ + + L +Q+ D + + E TL++ ++++E + L +L
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQL 2195
Query: 983 EESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041
EE+ + L +EL+ +K EA +QR E + S E +K + + R L+
Sbjct: 2196 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2255
Query: 1042 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1101
L + + LQ E + +K + E ++ AQ A RQ L E++ Q
Sbjct: 2256 -----LRDKDNTQRFLQEEAEKMKQVAE--EAARLSVAAQEAARLRQ---LAEEDLAQQR 2305
Query: 1102 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1161
A+ ++ Q + + A+LL QQ L E ++E D + + L ++ +
Sbjct: 2306 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQG 2363
Query: 1162 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-EDLEKMLKV 1220
+ E + + ++ LK + E+ + KQ ++ E L +
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2423
Query: 1221 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1280
QEK+ L +T+ + ++ + +RL ++L +E E LQ + K L+ L + +++
Sbjct: 2424 TQEKVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQ 2477
Query: 1281 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL 1340
+ E + Q+ ++ + L Q + +E+E L Q + + + L
Sbjct: 2478 TVQQE-------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530
Query: 1341 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
E+ + E+++ + + E RR++ + EE +
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2566
Score = 149 bits (376), Expect = 2e-35
Identities = 263/1251 (21%), Positives = 502/1251 (40%), Gaps = 183/1251 (14%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA-----RSAR 306
EL KA +++LR + E + + EL + +RLQQ + + R A+
Sbjct: 1124 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1183
Query: 307 MYRDELDALREKAVRVDKLES---EVSRYKERLHDIEFY----KARVEELK----EDNQV 355
+ L + VR +LE ++ Y+E + + + R E+++ D+Q
Sbjct: 1184 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1243
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME--ENM 413
+ E + LE +K+ E ++ Q + D E++ + ++E + +
Sbjct: 1244 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1303
Query: 414 TLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
++ + + E + L +++ TS+ + ++L E + + E E + L
Sbjct: 1304 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1362
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
+ L E +A + E+E + L ++ ++ E+V+ +++ + Q + +
Sbjct: 1363 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR---MQEEVVRREEAAVDAQQQKRSIQ 1419
Query: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAE------- 579
+E QL ++ E + RQ + E+ + + + +R +R + AE
Sbjct: 1420 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1479
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638
AR ++ E + + E + ++ KRQ + EL K + E A E + L LE
Sbjct: 1480 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1539
Query: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD----SFKNLTFQLE-SLE 693
+ LQ + ++ ++E Q LE R + L SF T QLE SL+
Sbjct: 1540 ELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597
Query: 694 KEN---SQLDEE-----------------------------NLELRRNVESLKCASMK-M 720
+E+ +QL EE N LR +++ + A K +
Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ-------------- 766
AQ + E ++ E+E+E ++G KA + + E++ Q L+ + Q
Sbjct: 1658 AQAEAEKQKEEAEREARRRG----KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1713
Query: 767 ---RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL-----KISSKRLEQLEKENK 818
RL+ E ++ Q LE EL L+ E + +EL K+ ++ L + +
Sbjct: 1714 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1773
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE------------IKDTTLEENNVKIGNLEKEN 866
+ E+ S EK K++LE E R R+ AE + L E + E E
Sbjct: 1774 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1833
Query: 867 KTLSKEIGIYK------ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
K I + E+ + LKE E EN+ L + A + L E K
Sbjct: 1834 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---- 1889
Query: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980
D+E ERL +++D + + +E TL++ ++ EE+I AL+A
Sbjct: 1890 ---DIE-------------ERLAQLRKASDSELERQKGLVEDTLRQRRQV-EEEILALKA 1932
Query: 981 RLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
E++ +L EL ++ N E L+ ++ E ++ E+ + RE++E ++
Sbjct: 1933 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1992
Query: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
L ++ E R E + LK +++ +A+ L + + S ++
Sbjct: 1993 SLAAEE---EAARQRKAALEEVERLKAKVE---------EARRLRERAEQESARQLQLAQ 2040
Query: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
+ +LQ E ++ + Q Q +QQ +SV+ + ++
Sbjct: 2041 EAAQKRLQAEEKA-HAFAVQQKEQELQQTLQQ------EQSVLDQLRGEAEAARRAAEEA 2093
Query: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
E+ + ER+A++ + + LK + + + +L K+ Q E +
Sbjct: 2094 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ----EAARR 2149
Query: 1220 VEQEKMLLENKNHETVAAE-YKKLCGENDRLNHTYSQLLK--ETEVLQTDHKNLKSLLNN 1276
+ E+ L K E +KK + R Q L ++ +TDH+ K+LL+
Sbjct: 2150 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ--KNLLDE 2207
Query: 1277 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL----DQIQT 1332
E RL+AE ++ Q Q++ + Q E LS+LK +E ENR L+ D Q
Sbjct: 2208 ---ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2264
Query: 1333 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR----QKEKLEEKIMDQ 1379
+ + ++Q E V Q +L +L Q+ L EK++ +
Sbjct: 2265 FLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQQRALAEKMLKE 2314
Score = 139 bits (351), Expect = 2e-32
Identities = 197/954 (20%), Positives = 413/954 (43%), Gaps = 127/954 (13%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
T+ ++ + L + +A + + E EL++ R + L + + A+ S
Sbjct: 1722 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1781
Query: 239 GMK---RTESRQHLSVELADAKAKIRRLRQE----------------------LEEKTEQ 273
K R E+ ELA+ A++R L +E L EK
Sbjct: 1782 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1841
Query: 274 LLDCKQELEQMEIELKRLQQENMNL--LSDARSARMYRDELDALREKAVRVDKL------ 325
+ + + + EI LK + EN L L++ + + R E A + KA ++L
Sbjct: 1842 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1901
Query: 326 -ESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARS-DKLHE 379
+SE+ R K + D + +VEE LK + K LE +L R+ + D L
Sbjct: 1902 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1961
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE----MAQKQSMDESLHLGWELEQ 435
E+ L+ A+ + E + R++ EE +++++ E +K +++E L ++E+
Sbjct: 1962 KEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2020
Query: 436 ISRTSELSEAPQKSLGHEVNELTSSRL--------LKLEMENQSLTKTVEELRTTVDSVE 487
R E +E E RL ++ + Q L +T+++ ++ +D +
Sbjct: 2021 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2080
Query: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIET 544
G A + +E + + E E Q ++ ++ + L + ++ +AQ + E
Sbjct: 2081 GEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
LR+ +E++ Q + ++LRQ+ AE +EK K +++++ +
Sbjct: 2138 LRKEAEQEAARRAQAEQ------AALRQKQAADAE-----MEKHKKFAEQTLRQKAQVEQ 2186
Query: 605 KIEFEKRQIKKELEHYKEK-GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
++ + Q++ E +H K E + L+ E ++ +++++ ++++ E++ L+
Sbjct: 2187 ELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK- 2244
Query: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK-MAQ 722
+ +E ENR L D F E EK +E R +V + + A ++ +A+
Sbjct: 2245 --ARIEAENRALILR-DKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAE 2298
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
L + +EK LK+ ++ ++ + + E+ Q ++ ++ ++ E+ + QQL
Sbjct: 2299 EDLAQQRALAEK-MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2357
Query: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
E Q + +TL+ + S E+L+ + + ++ E+D ++ K+ + +
Sbjct: 2358 AEETQGFQ---RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2414
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
++ + +E + LE + + + +E+ + ELE+E ++L + A +
Sbjct: 2415 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA---IAELEREKEKLQQEAKL--- 2468
Query: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
L SE+++T Q +E+LL + Q+ + S+ +S
Sbjct: 2469 ------LQLKSEEMQTVQ------------------QEQLLQETQALQQSFL---SEKDS 2501
Query: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1022
L++ I++EK A LE ++ QQLR+E + ++ E Q+ +R+V S
Sbjct: 2502 LLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQRQQQQME-----QERQRLVASME-- 2553
Query: 1023 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK-QALKTQLKQLETQN 1075
E + + E++E R + +L + R L AE+ Q L+ QL+ LE Q+
Sbjct: 2554 --EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2605
Score = 47.8 bits (112), Expect = 1e-04
Identities = 46/209 (22%), Positives = 93/209 (44%), Gaps = 23/209 (11%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH----FLPHASSSAQSP 234
T+++ ++ L++ + + ++ + + E I EL E++ L L S Q+
Sbjct: 2420 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2479
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD-----CKQELEQMEIELK 289
++ T++ Q + D+ + R ++ + K EQL +Q E+ + + +
Sbjct: 2480 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2539
Query: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
+++QE L++ AR + E E V R +E L +E + + EEL
Sbjct: 2540 QMEQERQRLVASMEEARRRQHEA-------------EEGVRRKQEELQQLEQQRRQQEEL 2586
Query: 350 -KEDNQVLLETKTMLEDQLEGTRARSDKL 377
E+NQ L E +LE+Q A S+++
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEV 2615
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 179 bits (453), Expect = 3e-44
Identities = 271/1296 (20%), Positives = 536/1296 (41%), Gaps = 116/1296 (8%)
Query: 115 EQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ 174
+Q EE ++L + Q Q E + + + K +EV +E D Q
Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1380
Query: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
+ + QE+++ L ++ ++ + + + + + EE + A+ +
Sbjct: 1381 QQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG- 1437
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
G+ G Q L +A+A+ R+ ++E E Q+ D Q Q E+EL
Sbjct: 1438 -GAEG-----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---- 1487
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
+ ++A +AR + L AL E ++ ++ E RL E +AR Q
Sbjct: 1488 --RVKAEAEAAREKQRALQALEELRLQAEEAE-------RRLRQAEVERAR------QVQ 1532
Query: 355 VLLET-KTMLEDQLEGTRAR-SDKLHELEK---ENLQLKAKLHDMEMERDMDRKKIEELM 409
V LET + E +L+ RA ++K +LE+ E A+L + R + + E
Sbjct: 1533 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1592
Query: 410 EE-NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE LE Q ++ +E+L L + E++++ L++A + E R E
Sbjct: 1593 EEAERELERWQLKA-NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1651
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE-------ILENEIVQEKQ-- 519
+ +EL EG A + L E+E RL + E +LE E+ + ++
Sbjct: 1652 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1711
Query: 520 --SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ Q Q L +L K +A++E + + E E+ + L R+ ++ +
Sbjct: 1712 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1771
Query: 578 AEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELEN 632
A R ++ +++ ++ E ++ ++ EK E K + E A +E EN
Sbjct: 1772 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1831
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS-FKNLTFQLES 691
E E+E Q++ E Q +++E +L+K DS + +E
Sbjct: 1832 ERLRRLAEDEAFQRRRLE--------EQAAQHKADIEERLAQLRKASDSELERQKGLVED 1883
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
++ Q++EE L L+ + E A+ A+L+LE + S E + E + +
Sbjct: 1884 TLRQRRQVEEEILALKASFEK---AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1940
Query: 752 ERLEVSYQGLDIE-NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
+L + E +R+QK+L + +Q ++ L+++E L+ +EE + +R
Sbjct: 1941 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARRLRERA 1996
Query: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKR----LRQQAEIKDTTLEENNVKIGNLEKEN 866
EQ L QE +Q K+L+ E K ++Q+ + TL++ + L E
Sbjct: 1997 EQESARQLQLAQEAAQ-----KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2051
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
+ + +E+ V+ + +++ V+ A L++ + Q E
Sbjct: 2052 EAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSAEEQAQARAQAQAAAE 2104
Query: 927 KLTHELEKIGLNK----ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
KL E E+ + + L +Q+ D + + E TL++ ++++E + L +L
Sbjct: 2105 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQL 2163
Query: 983 EESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041
EE+ + L +EL+ +K EA +QR E + S E +K + + R L+
Sbjct: 2164 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2223
Query: 1042 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1101
L + + LQ E + +K + E ++ AQ A RQ L E++ Q
Sbjct: 2224 -----LRDKDNTQRFLQEEAEKMKQVAE--EAARLSVAAQEAARLRQ---LAEEDLAQQR 2273
Query: 1102 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1161
A+ ++ Q + + A+LL QQ L E ++E D + + L ++ +
Sbjct: 2274 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQG 2331
Query: 1162 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-EDLEKMLKV 1220
+ E + + ++ LK + E+ + KQ ++ E L +
Sbjct: 2332 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2391
Query: 1221 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1280
QEK+ L +T+ + ++ + +RL ++L +E E LQ + K L+ L + +++
Sbjct: 2392 TQEKVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQ 2445
Query: 1281 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL 1340
+ E + Q+ ++ + L Q + +E+E L Q + + + L
Sbjct: 2446 TVQQE-------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2498
Query: 1341 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
E+ + E+++ + + E RR++ + EE +
Sbjct: 2499 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2534
Score = 149 bits (376), Expect = 2e-35
Identities = 263/1251 (21%), Positives = 502/1251 (40%), Gaps = 183/1251 (14%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA-----RSAR 306
EL KA +++LR + E + + EL + +RLQQ + + R A+
Sbjct: 1092 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1151
Query: 307 MYRDELDALREKAVRVDKLES---EVSRYKERLHDIEFY----KARVEELK----EDNQV 355
+ L + VR +LE ++ Y+E + + + R E+++ D+Q
Sbjct: 1152 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1211
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME--ENM 413
+ E + LE +K+ E ++ Q + D E++ + ++E + +
Sbjct: 1212 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1271
Query: 414 TLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
++ + + E + L +++ TS+ + ++L E + + E E + L
Sbjct: 1272 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1330
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
+ L E +A + E+E + L ++ ++ E+V+ +++ + Q + +
Sbjct: 1331 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR---MQEEVVRREEAAVDAQQQKRSIQ 1387
Query: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAE------- 579
+E QL ++ E + RQ + E+ + + + +R +R + AE
Sbjct: 1388 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1447
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638
AR ++ E + + E + ++ KRQ + EL K + E A E + L LE
Sbjct: 1448 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1507
Query: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD----SFKNLTFQLE-SLE 693
+ LQ + ++ ++E Q LE R + L SF T QLE SL+
Sbjct: 1508 ELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1565
Query: 694 KEN---SQLDEE-----------------------------NLELRRNVESLKCASMK-M 720
+E+ +QL EE N LR +++ + A K +
Sbjct: 1566 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1625
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ-------------- 766
AQ + E ++ E+E+E ++G KA + + E++ Q L+ + Q
Sbjct: 1626 AQAEAEKQKEEAEREARRRG----KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1681
Query: 767 ---RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL-----KISSKRLEQLEKENK 818
RL+ E ++ Q LE EL L+ E + +EL K+ ++ L + +
Sbjct: 1682 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1741
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE------------IKDTTLEENNVKIGNLEKEN 866
+ E+ S EK K++LE E R R+ AE + L E + E E
Sbjct: 1742 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1801
Query: 867 KTLSKEIGIYK------ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
K I + E+ + LKE E EN+ L + A + L E K
Sbjct: 1802 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---- 1857
Query: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980
D+E ERL +++D + + +E TL++ ++ EE+I AL+A
Sbjct: 1858 ---DIE-------------ERLAQLRKASDSELERQKGLVEDTLRQRRQV-EEEILALKA 1900
Query: 981 RLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
E++ +L EL ++ N E L+ ++ E ++ E+ + RE++E ++
Sbjct: 1901 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1960
Query: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
L ++ E R E + LK +++ +A+ L + + S ++
Sbjct: 1961 SLAAEE---EAARQRKAALEEVERLKAKVE---------EARRLRERAEQESARQLQLAQ 2008
Query: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
+ +LQ E ++ + Q Q +QQ +SV+ + ++
Sbjct: 2009 EAAQKRLQAEEKA-HAFAVQQKEQELQQTLQQ------EQSVLDQLRGEAEAARRAAEEA 2061
Query: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
E+ + ER+A++ + + LK + + + +L K+ Q E +
Sbjct: 2062 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ----EAARR 2117
Query: 1220 VEQEKMLLENKNHETVAAE-YKKLCGENDRLNHTYSQLLK--ETEVLQTDHKNLKSLLNN 1276
+ E+ L K E +KK + R Q L ++ +TDH+ K+LL+
Sbjct: 2118 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ--KNLLDE 2175
Query: 1277 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL----DQIQT 1332
E RL+AE ++ Q Q++ + Q E LS+LK +E ENR L+ D Q
Sbjct: 2176 ---ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2232
Query: 1333 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR----QKEKLEEKIMDQ 1379
+ + ++Q E V Q +L +L Q+ L EK++ +
Sbjct: 2233 FLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQQRALAEKMLKE 2282
Score = 139 bits (351), Expect = 2e-32
Identities = 197/954 (20%), Positives = 413/954 (43%), Gaps = 127/954 (13%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
T+ ++ + L + +A + + E EL++ R + L + + A+ S
Sbjct: 1690 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1749
Query: 239 GMK---RTESRQHLSVELADAKAKIRRLRQE----------------------LEEKTEQ 273
K R E+ ELA+ A++R L +E L EK
Sbjct: 1750 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1809
Query: 274 LLDCKQELEQMEIELKRLQQENMNL--LSDARSARMYRDELDALREKAVRVDKL------ 325
+ + + + EI LK + EN L L++ + + R E A + KA ++L
Sbjct: 1810 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1869
Query: 326 -ESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARS-DKLHE 379
+SE+ R K + D + +VEE LK + K LE +L R+ + D L
Sbjct: 1870 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1929
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE----MAQKQSMDESLHLGWELEQ 435
E+ L+ A+ + E + R++ EE +++++ E +K +++E L ++E+
Sbjct: 1930 KEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1988
Query: 436 ISRTSELSEAPQKSLGHEVNELTSSRL--------LKLEMENQSLTKTVEELRTTVDSVE 487
R E +E E RL ++ + Q L +T+++ ++ +D +
Sbjct: 1989 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2048
Query: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIET 544
G A + +E + + E E Q ++ ++ + L + ++ +AQ + E
Sbjct: 2049 GEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2105
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
LR+ +E++ Q + ++LRQ+ AE +EK K +++++ +
Sbjct: 2106 LRKEAEQEAARRAQAEQ------AALRQKQAADAE-----MEKHKKFAEQTLRQKAQVEQ 2154
Query: 605 KIEFEKRQIKKELEHYKEK-GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
++ + Q++ E +H K E + L+ E ++ +++++ ++++ E++ L+
Sbjct: 2155 ELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK- 2212
Query: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK-MAQ 722
+ +E ENR L D F E EK +E R +V + + A ++ +A+
Sbjct: 2213 --ARIEAENRALILR-DKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAE 2266
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
L + +EK LK+ ++ ++ + + E+ Q ++ ++ ++ E+ + QQL
Sbjct: 2267 EDLAQQRALAEK-MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2325
Query: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
E Q + +TL+ + S E+L+ + + ++ E+D ++ K+ + +
Sbjct: 2326 AEETQGFQ---RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2382
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
++ + +E + LE + + + +E+ + ELE+E ++L + A +
Sbjct: 2383 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA---IAELEREKEKLQQEAKL--- 2436
Query: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
L SE+++T Q +E+LL + Q+ + S+ +S
Sbjct: 2437 ------LQLKSEEMQTVQ------------------QEQLLQETQALQQSFL---SEKDS 2469
Query: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1022
L++ I++EK A LE ++ QQLR+E + ++ E Q+ +R+V S
Sbjct: 2470 LLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQRQQQQME-----QERQRLVASME-- 2521
Query: 1023 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK-QALKTQLKQLETQN 1075
E + + E++E R + +L + R L AE+ Q L+ QL+ LE Q+
Sbjct: 2522 --EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2573
Score = 47.8 bits (112), Expect = 1e-04
Identities = 46/209 (22%), Positives = 93/209 (44%), Gaps = 23/209 (11%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH----FLPHASSSAQSP 234
T+++ ++ L++ + + ++ + + E I EL E++ L L S Q+
Sbjct: 2388 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2447
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD-----CKQELEQMEIELK 289
++ T++ Q + D+ + R ++ + K EQL +Q E+ + + +
Sbjct: 2448 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2507
Query: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
+++QE L++ AR + E E V R +E L +E + + EEL
Sbjct: 2508 QMEQERQRLVASMEEARRRQHEA-------------EEGVRRKQEELQQLEQQRRQQEEL 2554
Query: 350 -KEDNQVLLETKTMLEDQLEGTRARSDKL 377
E+NQ L E +LE+Q A S+++
Sbjct: 2555 LAEENQRLREQLQLLEEQHRAALAHSEEV 2583
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 179 bits (453), Expect = 3e-44
Identities = 271/1296 (20%), Positives = 536/1296 (41%), Gaps = 116/1296 (8%)
Query: 115 EQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ 174
+Q EE ++L + Q Q E + + + K +EV +E D Q
Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1549
Query: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
+ + QE+++ L ++ ++ + + + + + EE + A+ +
Sbjct: 1550 QQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG- 1606
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
G+ G Q L +A+A+ R+ ++E E Q+ D Q Q E+EL
Sbjct: 1607 -GAEG-----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---- 1656
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
+ ++A +AR + L AL E ++ ++ E RL E +AR Q
Sbjct: 1657 --RVKAEAEAAREKQRALQALEELRLQAEEAE-------RRLRQAEVERAR------QVQ 1701
Query: 355 VLLET-KTMLEDQLEGTRAR-SDKLHELEK---ENLQLKAKLHDMEMERDMDRKKIEELM 409
V LET + E +L+ RA ++K +LE+ E A+L + R + + E
Sbjct: 1702 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1761
Query: 410 EE-NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE LE Q ++ +E+L L + E++++ L++A + E R E
Sbjct: 1762 EEAERELERWQLKA-NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1820
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE-------ILENEIVQEKQ-- 519
+ +EL EG A + L E+E RL + E +LE E+ + ++
Sbjct: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1880
Query: 520 --SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ Q Q L +L K +A++E + + E E+ + L R+ ++ +
Sbjct: 1881 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1940
Query: 578 AEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELEN 632
A R ++ +++ ++ E ++ ++ EK E K + E A +E EN
Sbjct: 1941 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS-FKNLTFQLES 691
E E+E Q++ E Q +++E +L+K DS + +E
Sbjct: 2001 ERLRRLAEDEAFQRRRLE--------EQAAQHKADIEERLAQLRKASDSELERQKGLVED 2052
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
++ Q++EE L L+ + E A+ A+L+LE + S E + E + +
Sbjct: 2053 TLRQRRQVEEEILALKASFEK---AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 2109
Query: 752 ERLEVSYQGLDIE-NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
+L + E +R+QK+L + +Q ++ L+++E L+ +EE + +R
Sbjct: 2110 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARRLRERA 2165
Query: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKR----LRQQAEIKDTTLEENNVKIGNLEKEN 866
EQ L QE +Q K+L+ E K ++Q+ + TL++ + L E
Sbjct: 2166 EQESARQLQLAQEAAQ-----KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
+ + +E+ V+ + +++ V+ A L++ + Q E
Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSAEEQAQARAQAQAAAE 2273
Query: 927 KLTHELEKIGLNK----ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
KL E E+ + + L +Q+ D + + E TL++ ++++E + L +L
Sbjct: 2274 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQL 2332
Query: 983 EESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041
EE+ + L +EL+ +K EA +QR E + S E +K + + R L+
Sbjct: 2333 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2392
Query: 1042 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1101
L + + LQ E + +K + E ++ AQ A RQ L E++ Q
Sbjct: 2393 -----LRDKDNTQRFLQEEAEKMKQVAE--EAARLSVAAQEAARLRQ---LAEEDLAQQR 2442
Query: 1102 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1161
A+ ++ Q + + A+LL QQ L E ++E D + + L ++ +
Sbjct: 2443 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQG 2500
Query: 1162 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-EDLEKMLKV 1220
+ E + + ++ LK + E+ + KQ ++ E L +
Sbjct: 2501 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2560
Query: 1221 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1280
QEK+ L +T+ + ++ + +RL ++L +E E LQ + K L+ L + +++
Sbjct: 2561 TQEKVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQ 2614
Query: 1281 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL 1340
+ E + Q+ ++ + L Q + +E+E L Q + + + L
Sbjct: 2615 TVQQE-------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2667
Query: 1341 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
E+ + E+++ + + E RR++ + EE +
Sbjct: 2668 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703
Score = 149 bits (376), Expect = 2e-35
Identities = 263/1251 (21%), Positives = 502/1251 (40%), Gaps = 183/1251 (14%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA-----RSAR 306
EL KA +++LR + E + + EL + +RLQQ + + R A+
Sbjct: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320
Query: 307 MYRDELDALREKAVRVDKLES---EVSRYKERLHDIEFY----KARVEELK----EDNQV 355
+ L + VR +LE ++ Y+E + + + R E+++ D+Q
Sbjct: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME--ENM 413
+ E + LE +K+ E ++ Q + D E++ + ++E + +
Sbjct: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440
Query: 414 TLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
++ + + E + L +++ TS+ + ++L E + + E E + L
Sbjct: 1441 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1499
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
+ L E +A + E+E + L ++ ++ E+V+ +++ + Q + +
Sbjct: 1500 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR---MQEEVVRREEAAVDAQQQKRSIQ 1556
Query: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAE------- 579
+E QL ++ E + RQ + E+ + + + +R +R + AE
Sbjct: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638
AR ++ E + + E + ++ KRQ + EL K + E A E + L LE
Sbjct: 1617 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1676
Query: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD----SFKNLTFQLE-SLE 693
+ LQ + ++ ++E Q LE R + L SF T QLE SL+
Sbjct: 1677 ELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734
Query: 694 KEN---SQLDEE-----------------------------NLELRRNVESLKCASMK-M 720
+E+ +QL EE N LR +++ + A K +
Sbjct: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1794
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ-------------- 766
AQ + E ++ E+E+E ++G KA + + E++ Q L+ + Q
Sbjct: 1795 AQAEAEKQKEEAEREARRRG----KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1850
Query: 767 ---RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL-----KISSKRLEQLEKENK 818
RL+ E ++ Q LE EL L+ E + +EL K+ ++ L + +
Sbjct: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1910
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE------------IKDTTLEENNVKIGNLEKEN 866
+ E+ S EK K++LE E R R+ AE + L E + E E
Sbjct: 1911 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1970
Query: 867 KTLSKEIGIYK------ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
K I + E+ + LKE E EN+ L + A + L E K
Sbjct: 1971 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---- 2026
Query: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980
D+E ERL +++D + + +E TL++ ++ EE+I AL+A
Sbjct: 2027 ---DIE-------------ERLAQLRKASDSELERQKGLVEDTLRQRRQV-EEEILALKA 2069
Query: 981 RLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
E++ +L EL ++ N E L+ ++ E ++ E+ + RE++E ++
Sbjct: 2070 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2129
Query: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
L ++ E R E + LK +++ +A+ L + + S ++
Sbjct: 2130 SLAAEE---EAARQRKAALEEVERLKAKVE---------EARRLRERAEQESARQLQLAQ 2177
Query: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
+ +LQ E ++ + Q Q +QQ +SV+ + ++
Sbjct: 2178 EAAQKRLQAEEKA-HAFAVQQKEQELQQTLQQ------EQSVLDQLRGEAEAARRAAEEA 2230
Query: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
E+ + ER+A++ + + LK + + + +L K+ Q E +
Sbjct: 2231 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ----EAARR 2286
Query: 1220 VEQEKMLLENKNHETVAAE-YKKLCGENDRLNHTYSQLLK--ETEVLQTDHKNLKSLLNN 1276
+ E+ L K E +KK + R Q L ++ +TDH+ K+LL+
Sbjct: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ--KNLLDE 2344
Query: 1277 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL----DQIQT 1332
E RL+AE ++ Q Q++ + Q E LS+LK +E ENR L+ D Q
Sbjct: 2345 ---ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401
Query: 1333 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR----QKEKLEEKIMDQ 1379
+ + ++Q E V Q +L +L Q+ L EK++ +
Sbjct: 2402 FLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQQRALAEKMLKE 2451
Score = 139 bits (351), Expect = 2e-32
Identities = 197/954 (20%), Positives = 413/954 (43%), Gaps = 127/954 (13%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
T+ ++ + L + +A + + E EL++ R + L + + A+ S
Sbjct: 1859 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1918
Query: 239 GMK---RTESRQHLSVELADAKAKIRRLRQE----------------------LEEKTEQ 273
K R E+ ELA+ A++R L +E L EK
Sbjct: 1919 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1978
Query: 274 LLDCKQELEQMEIELKRLQQENMNL--LSDARSARMYRDELDALREKAVRVDKL------ 325
+ + + + EI LK + EN L L++ + + R E A + KA ++L
Sbjct: 1979 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038
Query: 326 -ESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARS-DKLHE 379
+SE+ R K + D + +VEE LK + K LE +L R+ + D L
Sbjct: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE----MAQKQSMDESLHLGWELEQ 435
E+ L+ A+ + E + R++ EE +++++ E +K +++E L ++E+
Sbjct: 2099 KEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2157
Query: 436 ISRTSELSEAPQKSLGHEVNELTSSRL--------LKLEMENQSLTKTVEELRTTVDSVE 487
R E +E E RL ++ + Q L +T+++ ++ +D +
Sbjct: 2158 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217
Query: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIET 544
G A + +E + + E E Q ++ ++ + L + ++ +AQ + E
Sbjct: 2218 GEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
LR+ +E++ Q + ++LRQ+ AE +EK K +++++ +
Sbjct: 2275 LRKEAEQEAARRAQAEQ------AALRQKQAADAE-----MEKHKKFAEQTLRQKAQVEQ 2323
Query: 605 KIEFEKRQIKKELEHYKEK-GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
++ + Q++ E +H K E + L+ E ++ +++++ ++++ E++ L+
Sbjct: 2324 ELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK- 2381
Query: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK-MAQ 722
+ +E ENR L D F E EK +E R +V + + A ++ +A+
Sbjct: 2382 --ARIEAENRALILR-DKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAE 2435
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
L + +EK LK+ ++ ++ + + E+ Q ++ ++ ++ E+ + QQL
Sbjct: 2436 EDLAQQRALAEK-MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2494
Query: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
E Q + +TL+ + S E+L+ + + ++ E+D ++ K+ + +
Sbjct: 2495 AEETQGFQ---RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2551
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
++ + +E + LE + + + +E+ + ELE+E ++L + A +
Sbjct: 2552 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA---IAELEREKEKLQQEAKL--- 2605
Query: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
L SE+++T Q +E+LL + Q+ + S+ +S
Sbjct: 2606 ------LQLKSEEMQTVQ------------------QEQLLQETQALQQSFL---SEKDS 2638
Query: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1022
L++ I++EK A LE ++ QQLR+E + ++ E Q+ +R+V S
Sbjct: 2639 LLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQRQQQQME-----QERQRLVASME-- 2690
Query: 1023 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK-QALKTQLKQLETQN 1075
E + + E++E R + +L + R L AE+ Q L+ QL+ LE Q+
Sbjct: 2691 --EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742
Score = 47.8 bits (112), Expect = 1e-04
Identities = 46/209 (22%), Positives = 93/209 (44%), Gaps = 23/209 (11%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH----FLPHASSSAQSP 234
T+++ ++ L++ + + ++ + + E I EL E++ L L S Q+
Sbjct: 2557 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2616
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD-----CKQELEQMEIELK 289
++ T++ Q + D+ + R ++ + K EQL +Q E+ + + +
Sbjct: 2617 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2676
Query: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
+++QE L++ AR + E E V R +E L +E + + EEL
Sbjct: 2677 QMEQERQRLVASMEEARRRQHEA-------------EEGVRRKQEELQQLEQQRRQQEEL 2723
Query: 350 -KEDNQVLLETKTMLEDQLEGTRARSDKL 377
E+NQ L E +LE+Q A S+++
Sbjct: 2724 LAEENQRLREQLQLLEEQHRAALAHSEEV 2752
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 179 bits (453), Expect = 3e-44
Identities = 271/1296 (20%), Positives = 536/1296 (41%), Gaps = 116/1296 (8%)
Query: 115 EQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ 174
+Q EE ++L + Q Q E + + + K +EV +E D Q
Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1390
Query: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
+ + QE+++ L ++ ++ + + + + + EE + A+ +
Sbjct: 1391 QQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG- 1447
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
G+ G Q L +A+A+ R+ ++E E Q+ D Q Q E+EL
Sbjct: 1448 -GAEG-----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---- 1497
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
+ ++A +AR + L AL E ++ ++ E RL E +AR Q
Sbjct: 1498 --RVKAEAEAAREKQRALQALEELRLQAEEAE-------RRLRQAEVERAR------QVQ 1542
Query: 355 VLLET-KTMLEDQLEGTRAR-SDKLHELEK---ENLQLKAKLHDMEMERDMDRKKIEELM 409
V LET + E +L+ RA ++K +LE+ E A+L + R + + E
Sbjct: 1543 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1602
Query: 410 EE-NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE LE Q ++ +E+L L + E++++ L++A + E R E
Sbjct: 1603 EEAERELERWQLKA-NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1661
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE-------ILENEIVQEKQ-- 519
+ +EL EG A + L E+E RL + E +LE E+ + ++
Sbjct: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1721
Query: 520 --SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ Q Q L +L K +A++E + + E E+ + L R+ ++ +
Sbjct: 1722 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1781
Query: 578 AEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELEN 632
A R ++ +++ ++ E ++ ++ EK E K + E A +E EN
Sbjct: 1782 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS-FKNLTFQLES 691
E E+E Q++ E Q +++E +L+K DS + +E
Sbjct: 1842 ERLRRLAEDEAFQRRRLE--------EQAAQHKADIEERLAQLRKASDSELERQKGLVED 1893
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
++ Q++EE L L+ + E A+ A+L+LE + S E + E + +
Sbjct: 1894 TLRQRRQVEEEILALKASFEK---AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1950
Query: 752 ERLEVSYQGLDIE-NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
+L + E +R+QK+L + +Q ++ L+++E L+ +EE + +R
Sbjct: 1951 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARRLRERA 2006
Query: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKR----LRQQAEIKDTTLEENNVKIGNLEKEN 866
EQ L QE +Q K+L+ E K ++Q+ + TL++ + L E
Sbjct: 2007 EQESARQLQLAQEAAQ-----KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2061
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
+ + +E+ V+ + +++ V+ A L++ + Q E
Sbjct: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSAEEQAQARAQAQAAAE 2114
Query: 927 KLTHELEKIGLNK----ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
KL E E+ + + L +Q+ D + + E TL++ ++++E + L +L
Sbjct: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQL 2173
Query: 983 EESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041
EE+ + L +EL+ +K EA +QR E + S E +K + + R L+
Sbjct: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2233
Query: 1042 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1101
L + + LQ E + +K + E ++ AQ A RQ L E++ Q
Sbjct: 2234 -----LRDKDNTQRFLQEEAEKMKQVAE--EAARLSVAAQEAARLRQ---LAEEDLAQQR 2283
Query: 1102 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1161
A+ ++ Q + + A+LL QQ L E ++E D + + L ++ +
Sbjct: 2284 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQG 2341
Query: 1162 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-EDLEKMLKV 1220
+ E + + ++ LK + E+ + KQ ++ E L +
Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2401
Query: 1221 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1280
QEK+ L +T+ + ++ + +RL ++L +E E LQ + K L+ L + +++
Sbjct: 2402 TQEKVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQ 2455
Query: 1281 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL 1340
+ E + Q+ ++ + L Q + +E+E L Q + + + L
Sbjct: 2456 TVQQE-------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2508
Query: 1341 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
E+ + E+++ + + E RR++ + EE +
Sbjct: 2509 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
Score = 149 bits (376), Expect = 2e-35
Identities = 263/1251 (21%), Positives = 502/1251 (40%), Gaps = 183/1251 (14%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA-----RSAR 306
EL KA +++LR + E + + EL + +RLQQ + + R A+
Sbjct: 1102 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1161
Query: 307 MYRDELDALREKAVRVDKLES---EVSRYKERLHDIEFY----KARVEELK----EDNQV 355
+ L + VR +LE ++ Y+E + + + R E+++ D+Q
Sbjct: 1162 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1221
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME--ENM 413
+ E + LE +K+ E ++ Q + D E++ + ++E + +
Sbjct: 1222 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1281
Query: 414 TLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
++ + + E + L +++ TS+ + ++L E + + E E + L
Sbjct: 1282 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1340
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
+ L E +A + E+E + L ++ ++ E+V+ +++ + Q + +
Sbjct: 1341 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR---MQEEVVRREEAAVDAQQQKRSIQ 1397
Query: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAE------- 579
+E QL ++ E + RQ + E+ + + + +R +R + AE
Sbjct: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1457
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638
AR ++ E + + E + ++ KRQ + EL K + E A E + L LE
Sbjct: 1458 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1517
Query: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD----SFKNLTFQLE-SLE 693
+ LQ + ++ ++E Q LE R + L SF T QLE SL+
Sbjct: 1518 ELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575
Query: 694 KEN---SQLDEE-----------------------------NLELRRNVESLKCASMK-M 720
+E+ +QL EE N LR +++ + A K +
Sbjct: 1576 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1635
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ-------------- 766
AQ + E ++ E+E+E ++G KA + + E++ Q L+ + Q
Sbjct: 1636 AQAEAEKQKEEAEREARRRG----KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1691
Query: 767 ---RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL-----KISSKRLEQLEKENK 818
RL+ E ++ Q LE EL L+ E + +EL K+ ++ L + +
Sbjct: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1751
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE------------IKDTTLEENNVKIGNLEKEN 866
+ E+ S EK K++LE E R R+ AE + L E + E E
Sbjct: 1752 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1811
Query: 867 KTLSKEIGIYK------ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
K I + E+ + LKE E EN+ L + A + L E K
Sbjct: 1812 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---- 1867
Query: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980
D+E ERL +++D + + +E TL++ ++ EE+I AL+A
Sbjct: 1868 ---DIE-------------ERLAQLRKASDSELERQKGLVEDTLRQRRQV-EEEILALKA 1910
Query: 981 RLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
E++ +L EL ++ N E L+ ++ E ++ E+ + RE++E ++
Sbjct: 1911 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1970
Query: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
L ++ E R E + LK +++ +A+ L + + S ++
Sbjct: 1971 SLAAEE---EAARQRKAALEEVERLKAKVE---------EARRLRERAEQESARQLQLAQ 2018
Query: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
+ +LQ E ++ + Q Q +QQ +SV+ + ++
Sbjct: 2019 EAAQKRLQAEEKA-HAFAVQQKEQELQQTLQQ------EQSVLDQLRGEAEAARRAAEEA 2071
Query: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
E+ + ER+A++ + + LK + + + +L K+ Q E +
Sbjct: 2072 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ----EAARR 2127
Query: 1220 VEQEKMLLENKNHETVAAE-YKKLCGENDRLNHTYSQLLK--ETEVLQTDHKNLKSLLNN 1276
+ E+ L K E +KK + R Q L ++ +TDH+ K+LL+
Sbjct: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ--KNLLDE 2185
Query: 1277 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL----DQIQT 1332
E RL+AE ++ Q Q++ + Q E LS+LK +E ENR L+ D Q
Sbjct: 2186 ---ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
Query: 1333 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR----QKEKLEEKIMDQ 1379
+ + ++Q E V Q +L +L Q+ L EK++ +
Sbjct: 2243 FLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQQRALAEKMLKE 2292
Score = 139 bits (351), Expect = 2e-32
Identities = 197/954 (20%), Positives = 413/954 (43%), Gaps = 127/954 (13%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
T+ ++ + L + +A + + E EL++ R + L + + A+ S
Sbjct: 1700 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1759
Query: 239 GMK---RTESRQHLSVELADAKAKIRRLRQE----------------------LEEKTEQ 273
K R E+ ELA+ A++R L +E L EK
Sbjct: 1760 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1819
Query: 274 LLDCKQELEQMEIELKRLQQENMNL--LSDARSARMYRDELDALREKAVRVDKL------ 325
+ + + + EI LK + EN L L++ + + R E A + KA ++L
Sbjct: 1820 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1879
Query: 326 -ESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARS-DKLHE 379
+SE+ R K + D + +VEE LK + K LE +L R+ + D L
Sbjct: 1880 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE----MAQKQSMDESLHLGWELEQ 435
E+ L+ A+ + E + R++ EE +++++ E +K +++E L ++E+
Sbjct: 1940 KEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 1998
Query: 436 ISRTSELSEAPQKSLGHEVNELTSSRL--------LKLEMENQSLTKTVEELRTTVDSVE 487
R E +E E RL ++ + Q L +T+++ ++ +D +
Sbjct: 1999 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058
Query: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIET 544
G A + +E + + E E Q ++ ++ + L + ++ +AQ + E
Sbjct: 2059 GEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2115
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
LR+ +E++ Q + ++LRQ+ AE +EK K +++++ +
Sbjct: 2116 LRKEAEQEAARRAQAEQ------AALRQKQAADAE-----MEKHKKFAEQTLRQKAQVEQ 2164
Query: 605 KIEFEKRQIKKELEHYKEK-GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
++ + Q++ E +H K E + L+ E ++ +++++ ++++ E++ L+
Sbjct: 2165 ELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK- 2222
Query: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK-MAQ 722
+ +E ENR L D F E EK +E R +V + + A ++ +A+
Sbjct: 2223 --ARIEAENRALILR-DKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAE 2276
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
L + +EK LK+ ++ ++ + + E+ Q ++ ++ ++ E+ + QQL
Sbjct: 2277 EDLAQQRALAEK-MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2335
Query: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
E Q + +TL+ + S E+L+ + + ++ E+D ++ K+ + +
Sbjct: 2336 AEETQGFQ---RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2392
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
++ + +E + LE + + + +E+ + ELE+E ++L + A +
Sbjct: 2393 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA---IAELEREKEKLQQEAKL--- 2446
Query: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
L SE+++T Q +E+LL + Q+ + S+ +S
Sbjct: 2447 ------LQLKSEEMQTVQ------------------QEQLLQETQALQQSFL---SEKDS 2479
Query: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1022
L++ I++EK A LE ++ QQLR+E + ++ E Q+ +R+V S
Sbjct: 2480 LLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQRQQQQME-----QERQRLVASME-- 2531
Query: 1023 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK-QALKTQLKQLETQN 1075
E + + E++E R + +L + R L AE+ Q L+ QL+ LE Q+
Sbjct: 2532 --EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2583
Score = 47.8 bits (112), Expect = 1e-04
Identities = 46/209 (22%), Positives = 93/209 (44%), Gaps = 23/209 (11%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH----FLPHASSSAQSP 234
T+++ ++ L++ + + ++ + + E I EL E++ L L S Q+
Sbjct: 2398 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2457
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD-----CKQELEQMEIELK 289
++ T++ Q + D+ + R ++ + K EQL +Q E+ + + +
Sbjct: 2458 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2517
Query: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
+++QE L++ AR + E E V R +E L +E + + EEL
Sbjct: 2518 QMEQERQRLVASMEEARRRQHEA-------------EEGVRRKQEELQQLEQQRRQQEEL 2564
Query: 350 -KEDNQVLLETKTMLEDQLEGTRARSDKL 377
E+NQ L E +LE+Q A S+++
Sbjct: 2565 LAEENQRLREQLQLLEEQHRAALAHSEEV 2593
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 179 bits (453), Expect = 3e-44
Identities = 271/1296 (20%), Positives = 536/1296 (41%), Gaps = 116/1296 (8%)
Query: 115 EQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ 174
+Q EE ++L + Q Q E + + + K +EV +E D Q
Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1398
Query: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
+ + QE+++ L ++ ++ + + + + + EE + A+ +
Sbjct: 1399 QQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG- 1455
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
G+ G Q L +A+A+ R+ ++E E Q+ D Q Q E+EL
Sbjct: 1456 -GAEG-----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---- 1505
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
+ ++A +AR + L AL E ++ ++ E RL E +AR Q
Sbjct: 1506 --RVKAEAEAAREKQRALQALEELRLQAEEAE-------RRLRQAEVERAR------QVQ 1550
Query: 355 VLLET-KTMLEDQLEGTRAR-SDKLHELEK---ENLQLKAKLHDMEMERDMDRKKIEELM 409
V LET + E +L+ RA ++K +LE+ E A+L + R + + E
Sbjct: 1551 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1610
Query: 410 EE-NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE LE Q ++ +E+L L + E++++ L++A + E R E
Sbjct: 1611 EEAERELERWQLKA-NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1669
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE-------ILENEIVQEKQ-- 519
+ +EL EG A + L E+E RL + E +LE E+ + ++
Sbjct: 1670 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1729
Query: 520 --SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ Q Q L +L K +A++E + + E E+ + L R+ ++ +
Sbjct: 1730 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1789
Query: 578 AEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELEN 632
A R ++ +++ ++ E ++ ++ EK E K + E A +E EN
Sbjct: 1790 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1849
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS-FKNLTFQLES 691
E E+E Q++ E Q +++E +L+K DS + +E
Sbjct: 1850 ERLRRLAEDEAFQRRRLE--------EQAAQHKADIEERLAQLRKASDSELERQKGLVED 1901
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
++ Q++EE L L+ + E A+ A+L+LE + S E + E + +
Sbjct: 1902 TLRQRRQVEEEILALKASFEK---AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1958
Query: 752 ERLEVSYQGLDIE-NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
+L + E +R+QK+L + +Q ++ L+++E L+ +EE + +R
Sbjct: 1959 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARRLRERA 2014
Query: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKR----LRQQAEIKDTTLEENNVKIGNLEKEN 866
EQ L QE +Q K+L+ E K ++Q+ + TL++ + L E
Sbjct: 2015 EQESARQLQLAQEAAQ-----KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2069
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
+ + +E+ V+ + +++ V+ A L++ + Q E
Sbjct: 2070 EAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSAEEQAQARAQAQAAAE 2122
Query: 927 KLTHELEKIGLNK----ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
KL E E+ + + L +Q+ D + + E TL++ ++++E + L +L
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQL 2181
Query: 983 EESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041
EE+ + L +EL+ +K EA +QR E + S E +K + + R L+
Sbjct: 2182 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2241
Query: 1042 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1101
L + + LQ E + +K + E ++ AQ A RQ L E++ Q
Sbjct: 2242 -----LRDKDNTQRFLQEEAEKMKQVAE--EAARLSVAAQEAARLRQ---LAEEDLAQQR 2291
Query: 1102 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1161
A+ ++ Q + + A+LL QQ L E ++E D + + L ++ +
Sbjct: 2292 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQG 2349
Query: 1162 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-EDLEKMLKV 1220
+ E + + ++ LK + E+ + KQ ++ E L +
Sbjct: 2350 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2409
Query: 1221 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1280
QEK+ L +T+ + ++ + +RL ++L +E E LQ + K L+ L + +++
Sbjct: 2410 TQEKVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQ 2463
Query: 1281 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL 1340
+ E + Q+ ++ + L Q + +E+E L Q + + + L
Sbjct: 2464 TVQQE-------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2516
Query: 1341 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
E+ + E+++ + + E RR++ + EE +
Sbjct: 2517 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2552
Score = 149 bits (376), Expect = 2e-35
Identities = 263/1251 (21%), Positives = 502/1251 (40%), Gaps = 183/1251 (14%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA-----RSAR 306
EL KA +++LR + E + + EL + +RLQQ + + R A+
Sbjct: 1110 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1169
Query: 307 MYRDELDALREKAVRVDKLES---EVSRYKERLHDIEFY----KARVEELK----EDNQV 355
+ L + VR +LE ++ Y+E + + + R E+++ D+Q
Sbjct: 1170 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1229
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME--ENM 413
+ E + LE +K+ E ++ Q + D E++ + ++E + +
Sbjct: 1230 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1289
Query: 414 TLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
++ + + E + L +++ TS+ + ++L E + + E E + L
Sbjct: 1290 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1348
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
+ L E +A + E+E + L ++ ++ E+V+ +++ + Q + +
Sbjct: 1349 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR---MQEEVVRREEAAVDAQQQKRSIQ 1405
Query: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAE------- 579
+E QL ++ E + RQ + E+ + + + +R +R + AE
Sbjct: 1406 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1465
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638
AR ++ E + + E + ++ KRQ + EL K + E A E + L LE
Sbjct: 1466 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1525
Query: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD----SFKNLTFQLE-SLE 693
+ LQ + ++ ++E Q LE R + L SF T QLE SL+
Sbjct: 1526 ELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1583
Query: 694 KEN---SQLDEE-----------------------------NLELRRNVESLKCASMK-M 720
+E+ +QL EE N LR +++ + A K +
Sbjct: 1584 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1643
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ-------------- 766
AQ + E ++ E+E+E ++G KA + + E++ Q L+ + Q
Sbjct: 1644 AQAEAEKQKEEAEREARRRG----KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1699
Query: 767 ---RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL-----KISSKRLEQLEKENK 818
RL+ E ++ Q LE EL L+ E + +EL K+ ++ L + +
Sbjct: 1700 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1759
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE------------IKDTTLEENNVKIGNLEKEN 866
+ E+ S EK K++LE E R R+ AE + L E + E E
Sbjct: 1760 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1819
Query: 867 KTLSKEIGIYK------ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
K I + E+ + LKE E EN+ L + A + L E K
Sbjct: 1820 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---- 1875
Query: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980
D+E ERL +++D + + +E TL++ ++ EE+I AL+A
Sbjct: 1876 ---DIE-------------ERLAQLRKASDSELERQKGLVEDTLRQRRQV-EEEILALKA 1918
Query: 981 RLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
E++ +L EL ++ N E L+ ++ E ++ E+ + RE++E ++
Sbjct: 1919 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 1978
Query: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
L ++ E R E + LK +++ +A+ L + + S ++
Sbjct: 1979 SLAAEE---EAARQRKAALEEVERLKAKVE---------EARRLRERAEQESARQLQLAQ 2026
Query: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
+ +LQ E ++ + Q Q +QQ +SV+ + ++
Sbjct: 2027 EAAQKRLQAEEKA-HAFAVQQKEQELQQTLQQ------EQSVLDQLRGEAEAARRAAEEA 2079
Query: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
E+ + ER+A++ + + LK + + + +L K+ Q E +
Sbjct: 2080 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ----EAARR 2135
Query: 1220 VEQEKMLLENKNHETVAAE-YKKLCGENDRLNHTYSQLLK--ETEVLQTDHKNLKSLLNN 1276
+ E+ L K E +KK + R Q L ++ +TDH+ K+LL+
Sbjct: 2136 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ--KNLLDE 2193
Query: 1277 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL----DQIQT 1332
E RL+AE ++ Q Q++ + Q E LS+LK +E ENR L+ D Q
Sbjct: 2194 ---ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2250
Query: 1333 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR----QKEKLEEKIMDQ 1379
+ + ++Q E V Q +L +L Q+ L EK++ +
Sbjct: 2251 FLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQQRALAEKMLKE 2300
Score = 139 bits (351), Expect = 2e-32
Identities = 197/954 (20%), Positives = 413/954 (43%), Gaps = 127/954 (13%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
T+ ++ + L + +A + + E EL++ R + L + + A+ S
Sbjct: 1708 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1767
Query: 239 GMK---RTESRQHLSVELADAKAKIRRLRQE----------------------LEEKTEQ 273
K R E+ ELA+ A++R L +E L EK
Sbjct: 1768 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1827
Query: 274 LLDCKQELEQMEIELKRLQQENMNL--LSDARSARMYRDELDALREKAVRVDKL------ 325
+ + + + EI LK + EN L L++ + + R E A + KA ++L
Sbjct: 1828 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1887
Query: 326 -ESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARS-DKLHE 379
+SE+ R K + D + +VEE LK + K LE +L R+ + D L
Sbjct: 1888 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1947
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE----MAQKQSMDESLHLGWELEQ 435
E+ L+ A+ + E + R++ EE +++++ E +K +++E L ++E+
Sbjct: 1948 KEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2006
Query: 436 ISRTSELSEAPQKSLGHEVNELTSSRL--------LKLEMENQSLTKTVEELRTTVDSVE 487
R E +E E RL ++ + Q L +T+++ ++ +D +
Sbjct: 2007 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2066
Query: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIET 544
G A + +E + + E E Q ++ ++ + L + ++ +AQ + E
Sbjct: 2067 GEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2123
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
LR+ +E++ Q + ++LRQ+ AE +EK K +++++ +
Sbjct: 2124 LRKEAEQEAARRAQAEQ------AALRQKQAADAE-----MEKHKKFAEQTLRQKAQVEQ 2172
Query: 605 KIEFEKRQIKKELEHYKEK-GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
++ + Q++ E +H K E + L+ E ++ +++++ ++++ E++ L+
Sbjct: 2173 ELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK- 2230
Query: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK-MAQ 722
+ +E ENR L D F E EK +E R +V + + A ++ +A+
Sbjct: 2231 --ARIEAENRALILR-DKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAE 2284
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
L + +EK LK+ ++ ++ + + E+ Q ++ ++ ++ E+ + QQL
Sbjct: 2285 EDLAQQRALAEK-MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2343
Query: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
E Q + +TL+ + S E+L+ + + ++ E+D ++ K+ + +
Sbjct: 2344 AEETQGFQ---RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2400
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
++ + +E + LE + + + +E+ + ELE+E ++L + A +
Sbjct: 2401 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA---IAELEREKEKLQQEAKL--- 2454
Query: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
L SE+++T Q +E+LL + Q+ + S+ +S
Sbjct: 2455 ------LQLKSEEMQTVQ------------------QEQLLQETQALQQSFL---SEKDS 2487
Query: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1022
L++ I++EK A LE ++ QQLR+E + ++ E Q+ +R+V S
Sbjct: 2488 LLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQRQQQQME-----QERQRLVASME-- 2539
Query: 1023 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK-QALKTQLKQLETQN 1075
E + + E++E R + +L + R L AE+ Q L+ QL+ LE Q+
Sbjct: 2540 --EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2591
Score = 47.8 bits (112), Expect = 1e-04
Identities = 46/209 (22%), Positives = 93/209 (44%), Gaps = 23/209 (11%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH----FLPHASSSAQSP 234
T+++ ++ L++ + + ++ + + E I EL E++ L L S Q+
Sbjct: 2406 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2465
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD-----CKQELEQMEIELK 289
++ T++ Q + D+ + R ++ + K EQL +Q E+ + + +
Sbjct: 2466 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2525
Query: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
+++QE L++ AR + E E V R +E L +E + + EEL
Sbjct: 2526 QMEQERQRLVASMEEARRRQHEA-------------EEGVRRKQEELQQLEQQRRQQEEL 2572
Query: 350 -KEDNQVLLETKTMLEDQLEGTRARSDKL 377
E+NQ L E +LE+Q A S+++
Sbjct: 2573 LAEENQRLREQLQLLEEQHRAALAHSEEV 2601
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 179 bits (453), Expect = 3e-44
Identities = 271/1296 (20%), Positives = 536/1296 (41%), Gaps = 116/1296 (8%)
Query: 115 EQGTEEVKKLLLLLLGCAVQCQKKEEFIERIQGLDFDTKAAVAAHIQEVTHNQENVFDLQ 174
+Q EE ++L + Q Q E + + + K +EV +E D Q
Sbjct: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQ 1439
Query: 175 WMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSP 234
+ + QE+++ L ++ ++ + + + + + EE + A+ +
Sbjct: 1440 QQKRS--IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRG- 1496
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQE 294
G+ G Q L +A+A+ R+ ++E E Q+ D Q Q E+EL
Sbjct: 1497 -GAEG-----ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELAS---- 1546
Query: 295 NMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQ 354
+ ++A +AR + L AL E ++ ++ E RL E +AR Q
Sbjct: 1547 --RVKAEAEAAREKQRALQALEELRLQAEEAE-------RRLRQAEVERAR------QVQ 1591
Query: 355 VLLET-KTMLEDQLEGTRAR-SDKLHELEK---ENLQLKAKLHDMEMERDMDRKKIEELM 409
V LET + E +L+ RA ++K +LE+ E A+L + R + + E
Sbjct: 1592 VALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAR 1651
Query: 410 EE-NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
EE LE Q ++ +E+L L + E++++ L++A + E R E
Sbjct: 1652 EEAERELERWQLKA-NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQA 1710
Query: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVE-------ILENEIVQEKQ-- 519
+ +EL EG A + L E+E RL + E +LE E+ + ++
Sbjct: 1711 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREA 1770
Query: 520 --SLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQIS 577
+ Q Q L +L K +A++E + + E E+ + L R+ ++ +
Sbjct: 1771 AAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1830
Query: 578 AEARV--KDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERA---EELEN 632
A R ++ +++ ++ E ++ ++ EK E K + E A +E EN
Sbjct: 1831 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1890
Query: 633 ELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDS-FKNLTFQLES 691
E E+E Q++ E Q +++E +L+K DS + +E
Sbjct: 1891 ERLRRLAEDEAFQRRRLE--------EQAAQHKADIEERLAQLRKASDSELERQKGLVED 1942
Query: 692 LEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKT 751
++ Q++EE L L+ + E A+ A+L+LE + S E + E + +
Sbjct: 1943 TLRQRRQVEEEILALKASFEK---AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQ 1999
Query: 752 ERLEVSYQGLDIE-NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRL 810
+L + E +R+QK+L + +Q ++ L+++E L+ +EE + +R
Sbjct: 2000 RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER----LKAKVEEARRLRERA 2055
Query: 811 EQLEKENKSLEQETSQLEKDKKQLEKENKR----LRQQAEIKDTTLEENNVKIGNLEKEN 866
EQ L QE +Q K+L+ E K ++Q+ + TL++ + L E
Sbjct: 2056 EQESARQLQLAQEAAQ-----KRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110
Query: 867 KTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE 926
+ + +E+ V+ + +++ V+ A L++ + Q E
Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAE-------RLKQSAEEQAQARAQAQAAAE 2163
Query: 927 KLTHELEKIGLNK----ERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARL 982
KL E E+ + + L +Q+ D + + E TL++ ++++E + L +L
Sbjct: 2164 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE-LTTLRLQL 2222
Query: 983 EESTNYNQQLRQELKTVKKNY-EALKQRQDEERMVQSSPPISGEDNKWERESQETTRELL 1041
EE+ + L +EL+ +K EA +QR E + S E +K + + R L+
Sbjct: 2223 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2282
Query: 1042 KVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1101
L + + LQ E + +K + E ++ AQ A RQ L E++ Q
Sbjct: 2283 -----LRDKDNTQRFLQEEAEKMKQVAE--EAARLSVAAQEAARLRQ---LAEEDLAQQR 2332
Query: 1102 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK 1161
A+ ++ Q + + A+LL QQ L E ++E D + + L ++ +
Sbjct: 2333 ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLAEETQG 2390
Query: 1162 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-EDLEKMLKV 1220
+ E + + ++ LK + E+ + KQ ++ E L +
Sbjct: 2391 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELA 2450
Query: 1221 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1280
QEK+ L +T+ + ++ + +RL ++L +E E LQ + K L+ L + +++
Sbjct: 2451 TQEKVTLV----QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ--LKSEEMQ 2504
Query: 1281 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTL 1340
+ E + Q+ ++ + L Q + +E+E L Q + + + L
Sbjct: 2505 TVQQE-------QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2557
Query: 1341 LEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKI 1376
E+ + E+++ + + E RR++ + EE +
Sbjct: 2558 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2593
Score = 149 bits (376), Expect = 2e-35
Identities = 263/1251 (21%), Positives = 502/1251 (40%), Gaps = 183/1251 (14%)
Query: 252 ELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDA-----RSAR 306
EL KA +++LR + E + + EL + +RLQQ + + R A+
Sbjct: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210
Query: 307 MYRDELDALREKAVRVDKLES---EVSRYKERLHDIEFY----KARVEELK----EDNQV 355
+ L + VR +LE ++ Y+E + + + R E+++ D+Q
Sbjct: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270
Query: 356 LLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELME--ENM 413
+ E + LE +K+ E ++ Q + D E++ + ++E + +
Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330
Query: 414 TLEMAQKQSMDESLHLGWELEQISR-TSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
++ + + E + L +++ TS+ + ++L E + + E E + L
Sbjct: 1331 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE-ERERL 1389
Query: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLM 532
+ L E +A + E+E + L ++ ++ E+V+ +++ + Q + +
Sbjct: 1390 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQR---MQEEVVRREEAAVDAQQQKRSIQ 1446
Query: 533 KEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR------QRSQISAE------- 579
+E QL ++ E + RQ + E+ + + + +R +R + AE
Sbjct: 1447 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1506
Query: 580 ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKEL-EHYKEKGERAEELENELHHLE 638
AR ++ E + + E + ++ KRQ + EL K + E A E + L LE
Sbjct: 1507 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE 1566
Query: 639 KENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLD----SFKNLTFQLE-SLE 693
+ LQ + ++ ++E Q LE R + L SF T QLE SL+
Sbjct: 1567 ELR--LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1624
Query: 694 KEN---SQLDEE-----------------------------NLELRRNVESLKCASMK-M 720
+E+ +QL EE N LR +++ + A K +
Sbjct: 1625 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1684
Query: 721 AQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ-------------- 766
AQ + E ++ E+E+E ++G KA + + E++ Q L+ + Q
Sbjct: 1685 AQAEAEKQKEEAEREARRRG----KAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQ 1740
Query: 767 ---RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEEL-----KISSKRLEQLEKENK 818
RL+ E ++ Q LE EL L+ E + +EL K+ ++ L + +
Sbjct: 1741 ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKAR 1800
Query: 819 SLEQETSQLEKDKKQLEKENKRLRQQAE------------IKDTTLEENNVKIGNLEKEN 866
+ E+ S EK K++LE E R R+ AE + L E + E E
Sbjct: 1801 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1860
Query: 867 KTLSKEIGIYK------ESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQ 920
K I + E+ + LKE E EN+ L + A + L E K
Sbjct: 1861 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA---- 1916
Query: 921 MNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEA 980
D+E ERL +++D + + +E TL++ ++ EE+I AL+A
Sbjct: 1917 ---DIE-------------ERLAQLRKASDSELERQKGLVEDTLRQRRQV-EEEILALKA 1959
Query: 981 RLEESTNYNQQLRQELKTVKKNYE-ALKQRQDEERMVQSSPPISGEDNKWERESQETTRE 1039
E++ +L EL ++ N E L+ ++ E ++ E+ + RE++E ++
Sbjct: 1960 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQK 2019
Query: 1040 LLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTL 1099
L ++ E R E + LK +++ +A+ L + + S ++
Sbjct: 2020 SLAAEE---EAARQRKAALEEVERLKAKVE---------EARRLRERAEQESARQLQLAQ 2067
Query: 1100 QTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDH 1159
+ +LQ E ++ + Q Q +QQ +SV+ + ++
Sbjct: 2068 EAAQKRLQAEEKA-HAFAVQQKEQELQQTLQQ------EQSVLDQLRGEAEAARRAAEEA 2120
Query: 1160 EKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLK 1219
E+ + ER+A++ + + LK + + + +L K+ Q E +
Sbjct: 2121 EEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ----EAARR 2176
Query: 1220 VEQEKMLLENKNHETVAAE-YKKLCGENDRLNHTYSQLLK--ETEVLQTDHKNLKSLLNN 1276
+ E+ L K E +KK + R Q L ++ +TDH+ K+LL+
Sbjct: 2177 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQ--KNLLDE 2234
Query: 1277 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLL----DQIQT 1332
E RL+AE ++ Q Q++ + Q E LS+LK +E ENR L+ D Q
Sbjct: 2235 ---ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2291
Query: 1333 LMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR----QKEKLEEKIMDQ 1379
+ + ++Q E V Q +L +L Q+ L EK++ +
Sbjct: 2292 FLQEEAEKMKQVAEEAARLSV-AAQEAARLRQLAEEDLAQQRALAEKMLKE 2341
Score = 139 bits (351), Expect = 2e-32
Identities = 197/954 (20%), Positives = 413/954 (43%), Gaps = 127/954 (13%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
T+ ++ + L + +A + + E EL++ R + L + + A+ S
Sbjct: 1749 TEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1808
Query: 239 GMK---RTESRQHLSVELADAKAKIRRLRQE----------------------LEEKTEQ 273
K R E+ ELA+ A++R L +E L EK
Sbjct: 1809 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1868
Query: 274 LLDCKQELEQMEIELKRLQQENMNL--LSDARSARMYRDELDALREKAVRVDKL------ 325
+ + + + EI LK + EN L L++ + + R E A + KA ++L
Sbjct: 1869 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 1928
Query: 326 -ESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQLEGTRARS-DKLHE 379
+SE+ R K + D + +VEE LK + K LE +L R+ + D L
Sbjct: 1929 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1988
Query: 380 LEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLE----MAQKQSMDESLHLGWELEQ 435
E+ L+ A+ + E + R++ EE +++++ E +K +++E L ++E+
Sbjct: 1989 KEQAELEA-ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEE 2047
Query: 436 ISRTSELSEAPQKSLGHEVNELTSSRL--------LKLEMENQSLTKTVEELRTTVDSVE 487
R E +E E RL ++ + Q L +T+++ ++ +D +
Sbjct: 2048 ARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2107
Query: 488 GNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE---KAQLEKTIET 544
G A + +E + + E E Q ++ ++ + L + ++ +AQ + E
Sbjct: 2108 GEAEAARRAAEEAEEARVQAE---REAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2164
Query: 545 LRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLS 604
LR+ +E++ Q + ++LRQ+ AE +EK K +++++ +
Sbjct: 2165 LRKEAEQEAARRAQAEQ------AALRQKQAADAE-----MEKHKKFAEQTLRQKAQVEQ 2213
Query: 605 KIEFEKRQIKKELEHYKEK-GERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQ 663
++ + Q++ E +H K E + L+ E ++ +++++ ++++ E++ L+
Sbjct: 2214 ELTTLRLQLE-ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK- 2271
Query: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMK-MAQ 722
+ +E ENR L D F E EK +E R +V + + A ++ +A+
Sbjct: 2272 --ARIEAENRALILR-DKDNTQRFLQEEAEKMKQVAEEA---ARLSVAAQEAARLRQLAE 2325
Query: 723 LQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQL 782
L + +EK LK+ ++ ++ + + E+ Q ++ ++ ++ E+ + QQL
Sbjct: 2326 EDLAQQRALAEK-MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQL 2384
Query: 783 ESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLR 842
E Q + +TL+ + S E+L+ + + ++ E+D ++ K+ + +
Sbjct: 2385 AEETQGFQ---RTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIG 2441
Query: 843 QQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIK 902
++ + +E + LE + + + +E+ + ELE+E ++L + A +
Sbjct: 2442 EKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA---IAELEREKEKLQQEAKL--- 2495
Query: 903 TLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLES 962
L SE+++T Q +E+LL + Q+ + S+ +S
Sbjct: 2496 ------LQLKSEEMQTVQ------------------QEQLLQETQALQQSFL---SEKDS 2528
Query: 963 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1022
L++ I++EK A LE ++ QQLR+E + ++ E Q+ +R+V S
Sbjct: 2529 LLQRERFIEQEK-AKLEQLFQDEVAKAQQLREEQQRQQQQME-----QERQRLVASME-- 2580
Query: 1023 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK-QALKTQLKQLETQN 1075
E + + E++E R + +L + R L AE+ Q L+ QL+ LE Q+
Sbjct: 2581 --EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2632
Score = 47.8 bits (112), Expect = 1e-04
Identities = 46/209 (22%), Positives = 93/209 (44%), Gaps = 23/209 (11%)
Query: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDGLH----FLPHASSSAQSP 234
T+++ ++ L++ + + ++ + + E I EL E++ L L S Q+
Sbjct: 2447 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTV 2506
Query: 235 CGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLD-----CKQELEQMEIELK 289
++ T++ Q + D+ + R ++ + K EQL +Q E+ + + +
Sbjct: 2507 QQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQ 2566
Query: 290 RLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEEL 349
+++QE L++ AR + E E V R +E L +E + + EEL
Sbjct: 2567 QMEQERQRLVASMEEARRRQHEA-------------EEGVRRKQEELQQLEQQRRQQEEL 2613
Query: 350 -KEDNQVLLETKTMLEDQLEGTRARSDKL 377
E+NQ L E +LE+Q A S+++
Sbjct: 2614 LAEENQRLREQLQLLEEQHRAALAHSEEV 2642
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 179 bits (453), Expect = 3e-44
Identities = 258/1122 (22%), Positives = 487/1122 (43%), Gaps = 116/1122 (10%)
Query: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE-----------QMEIELKRLQ 292
E Q ELA ++AK R+ELEEK LL K +L+ E ++L
Sbjct: 857 EEFQKTKDELAKSEAK----RKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLI 912
Query: 293 QENMNLLSDARSARMYRDELDALR-EKAVRVDKLESEVSRYKERLHDIEFYKARVEELKE 351
+ + L + + +E + + E + KLE E S K+ + D+E A+VE+ K
Sbjct: 913 KNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKH 972
Query: 352 DNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ--LKAKLHDMEMERDMDRKKIEELM 409
+ ++ T L+ T A+ K EK+ LQ + L D++ E D K+ L
Sbjct: 973 ATENKVKNLTEEMAGLDETIAKLSK----EKKALQETHQQTLDDLQAEED----KVNILT 1024
Query: 410 EENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMEN 469
+ LE Q +D+ L LEQ + E ++ L ++ +L + +E +
Sbjct: 1025 KAKTKLE----QQVDD---LEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESTMDMENDK 1076
Query: 470 QSLTKTVE----ELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQ 525
Q L + +E E+ + +E + ++++K+ + L ++E L EI E+ S +
Sbjct: 1077 QQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAE 1136
Query: 526 NLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDI 585
DL +E ++ + +E + Q++ L ++ E Q + + + + EA V +
Sbjct: 1137 KQRSDLSRELEEISERLEEAGGATSAQVE-LNKKREAEFQKLRRDLEEATLQHEAMVAAL 1195
Query: 586 EKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQ 645
K++ +S+ E ++ ++ K++++KE EL+ E L E +
Sbjct: 1196 RKKHA---DSMAELGEQIDNLQRVKQKLEKE----------KSELKMETDDLSSNAEAIS 1242
Query: 646 KKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE----NSQLDE 701
K NL+ C +E E E E ++L +LT Q L+ E + QLDE
Sbjct: 1243 KAKGNLEKMCRSLEDQVSELKTKEEEQQRL------INDLTAQRARLQTEAGEYSRQLDE 1296
Query: 702 ENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGL 761
++ + + S + ++ ++ +L+ +LE E + L++S + L Y+
Sbjct: 1297 KDALVSQLSRSKQASTQQIEELK---HQLEEETKAKNALAHALQSSRHDCDLLREQYEEE 1353
Query: 762 DIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLE 821
LQ+ L +N ++ Q + + E +Q+ EEL+ + K+L Q +E E
Sbjct: 1354 QEGKAELQRALSKANSEVAQWRT-----KYETDAIQRT-EELEEAKKKLAQRLQE---AE 1404
Query: 822 QETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKE----NKTLSKEIGIYK 877
+ + LEK +RL+ + E +E +N L+K+ +K LS+ Y+
Sbjct: 1405 EHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYE 1464
Query: 878 ESCVRLKELEKENK----ELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLE------- 926
E+ L+ +KE++ EL K + ++L L E L E QQ +DL
Sbjct: 1465 ETQAELEASQKESRSLSTELFKVKNVYEESLDQL-ETLRRENKNLQQEISDLTEQIAEGG 1523
Query: 927 KLTHELEKIGLNKERLLHDEQST-DDRYKLLESKLESTLKKSLEIKEEKIAALEARLEES 985
K HELEKI E+ + Q+ ++ LE + L+ LE+ + K + ++ ++ E
Sbjct: 1524 KQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVK-SEVDRKIAEK 1582
Query: 986 TNYNQQLRQE----LKTVKKNYEA-LKQRQDEERMVQSSPPISGEDNKWE-------RES 1033
QL++ ++T++ +A ++ R D R+ + + G+ N+ E R +
Sbjct: 1583 DEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKK---MEGDLNEMEIQLNHANRLA 1639
Query: 1034 QETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQ 1093
E+ R + L E + + ++ LK QL +E + N LQA+I L +
Sbjct: 1640 AESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTE 1699
Query: 1094 EQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYD 1153
+ + L++Q+TSL+N +L S L++E E VI+E + +
Sbjct: 1700 RSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAK 1759
Query: 1154 SLIKDHEKL--ELLHERQASEYESLISKH--GTLKS-AHKNLEVEHRDLEDRYNQLLKQK 1208
I D + EL E+ S + + K+ T+K H+ E E L+ Q+ K +
Sbjct: 1760 KAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLE 1819
Query: 1209 GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHK 1268
++ +LE ++ EQ++ K K+L + + +L + LQ K
Sbjct: 1820 ARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQDLVDKLQAKVK 1879
Query: 1269 NLKSLLNNSKLEQTRLEAEFSK----LKEQYQQLDITSTKLN 1306
+ K ++ + ++F K L+E ++ DI +++N
Sbjct: 1880 SYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVN 1921
Score = 158 bits (399), Expect = 5e-38
Identities = 216/1057 (20%), Positives = 458/1057 (43%), Gaps = 168/1057 (15%)
Query: 149 DFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQE--DIEPLLKNMALHLKRLIDERDE 206
D D A +++ H EN +V ++++E ++ + ++ K L ++
Sbjct: 956 DIDDLELTLAKVEKEKHATEN-------KVKNLTEEMAGLDETIAKLSKEKKAL---QET 1005
Query: 207 HSETIIELSEERDGLHFLPHASSSAQSPCGS-PGMKRTESRQHLSVELADAKAKIRRLRQ 265
H +T+ +L E D ++ L A + + G E + + +E A R+L
Sbjct: 1006 HQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAK-----RKLEG 1060
Query: 266 ELEEKTEQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDA-LREKAVRVDK 324
+L+ E +D + + +Q++ +L++ + E NL+S + +L ++E R+++
Sbjct: 1061 DLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEE 1120
Query: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384
L E+ + +A+ E+ + D LE + ++LE + EL K
Sbjct: 1121 LGEEIEAERAS-------RAKAEKQRSDLSRELEE---ISERLEEAGGATSAQVELNK-- 1168
Query: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSE 444
K + ++ RD++ E ++ + +K+ D LG +++ + R + E
Sbjct: 1169 ---KREAEFQKLRRDLE----EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLE 1221
Query: 445 APQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLS 504
+ L E ++L+S+ ++++K L S+E S++ E+E QRL
Sbjct: 1222 KEKSELKMETDDLSSNA--------EAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLI 1273
Query: 505 KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564
N++ ++ LQ + EK L + ++ S +QI+ L+ + E
Sbjct: 1274 -------NDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEET 1326
Query: 565 QTVSSLR---QRSQISAEARVKDIEKEN-------KILHESIKETSSKLSKIEFEKRQIK 614
+ ++L Q S+ + + E+E + L ++ E + +K E + Q
Sbjct: 1327 KAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRT 1386
Query: 615 KELEHYKEK-GERAEELENELH-------HLEKENELLQKKITNLKITCEKIEAL----- 661
+ELE K+K +R +E E + LEK + LQ ++ +L + E+ A
Sbjct: 1387 EELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALD 1446
Query: 662 -----------------EQENSELE---RENRKLKKTLDSFKNL----TFQLESLEKENS 697
E+ +ELE +E+R L L KN+ QLE+L +EN
Sbjct: 1447 KKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENK 1506
Query: 698 QLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE----- 752
L +E +L E + ++ +L+ K++E EK +++ LE +AS + E
Sbjct: 1507 NLQQEISDL---TEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILR 1563
Query: 753 -RLEVSYQGLDIENQRLQKTLE------NSNKKIQQLESELQ-DLEMENQTL------QK 798
+LE++ +++ + +K E N + ++ ++S L ++ N L +
Sbjct: 1564 IQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEG 1623
Query: 799 NLEELKISSKRLEQLEKENKSLEQETSQLEKD-----------KKQLEKENKRLRQQAEI 847
+L E++I +L E+ + T + K+ ++ L+++ + ++A +
Sbjct: 1624 DLNEMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANL 1683
Query: 848 KDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELV---KRATIDIKTL 904
+EE + E+ K +E+ ++ R++ L +N L+ K+ D+ L
Sbjct: 1684 LQAEIEELWATLEQTERSRKIAEQEL---LDASERVQLLHTQNTSLINTKKKLENDVSQL 1740
Query: 905 VTLREDLVSEKL----KTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKL 960
+ E+++ E K ++ D + EL+K L +++ + K L+ +L
Sbjct: 1741 QSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRL 1800
Query: 961 ESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTV-KKNYEALKQRQDEERMVQSS 1019
+ + +L+ +++I LEAR+ E L E++ K+N EA+K + ER V+
Sbjct: 1801 DEAEQLALKGGKKQIQKLEARVRE-------LEGEVENEQKRNAEAVKGLRKHERRVKEL 1853
Query: 1020 PPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQ 1079
+ ED K +L+++D + + LQA+ ++ K Q ++ E Q+N
Sbjct: 1854 TYQTEEDRK----------NVLRLQDLVDK-------LQAKVKSYKRQAEEAEEQSNANL 1896
Query: 1080 AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQ 1116
++ LQ + +E+ ++Q KL+V++ ++++
Sbjct: 1897 SKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTK 1933
Score = 122 bits (305), Expect = 4e-27
Identities = 169/782 (21%), Positives = 344/782 (43%), Gaps = 80/782 (10%)
Query: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
+++E E+E +K+ K+ +L E + +L+E+ + L + L QL
Sbjct: 844 KSAETEKEMATMKEEFQKTKD---ELAKSEAKRKELEEKMVTLLKEKNDL--------QL 892
Query: 724 QLENK-----ELESEKEQLKKGLELLKASFKK-TERLEVSYQ---GLDIENQRLQKTLEN 774
Q++++ + E EQL K L+A K+ TER E + L + ++L+
Sbjct: 893 QVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSE 952
Query: 775 SNKKIQQLESELQDLEMENQTLQ---KNL-EELKISSKRLEQLEKENKSLEQ------ET 824
K I LE L +E E + KNL EE+ + + +L KE K+L++ +
Sbjct: 953 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012
Query: 825 SQLEKDKKQ-LEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRL 883
Q E+DK L K +L QQ + + +LE+ +LE+ + L ++ + +ES + +
Sbjct: 1013 LQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDM 1072
Query: 884 KELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLL 943
+ +++ E +++ +I L++ ED E+ Q+ +++L +E++G E
Sbjct: 1073 ENDKQQLDEKLEKKEFEISNLISKIED---EQAVEIQLQKKIKELQARIEELGEEIEA-- 1127
Query: 944 HDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN---QQLRQELKTVK 1000
E+++ + + S L L++ E EE A A++E + Q+LR++L+
Sbjct: 1128 --ERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEAT 1185
Query: 1001 KNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAE 1060
+EA+ ++ S + + + +R Q+ +E ++K ++ N +
Sbjct: 1186 LQHEAMVAAL-RKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKA 1244
Query: 1061 KQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSL 1120
K L+ + LE Q + L+ + QR L Q LQT+ + + ++ S
Sbjct: 1245 KGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDA-LVSQ 1303
Query: 1121 MNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKH 1180
++++ Q QQ +E + +E + +L +L +LL E+ E E
Sbjct: 1304 LSRSKQASTQQ--IEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQ 1361
Query: 1181 GTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH-ETVAAEY 1239
L A+ + E +++ +LE+ +K L + L E + H E V A+
Sbjct: 1362 RALSKANSEVAQWRTKYE---TDAIQRTEELEEAKKKL----AQRLQEAEEHVEAVNAKC 1414
Query: 1240 KKLCGENDRLNHTYSQLLKETE-------VLQTDHKNLKSLLN--NSKLEQTRLEAEFSK 1290
L RL + L+ + E L +N +L+ K E+T+ E E S+
Sbjct: 1415 ASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQ 1474
Query: 1291 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1350
+ + ++ K N+ EE+ LDQ++TL +N+ L ++ + +
Sbjct: 1475 KESRSLSTELFKVK-------------NVYEES---LDQLETLRRENKNLQQEISDLTEQ 1518
Query: 1351 FHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDIN 1410
E + I +L ++++Q E+ + +I + + S G + +++ +L + K +++
Sbjct: 1519 I-AEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQL-ELNQVKSEVD 1576
Query: 1411 RE 1412
R+
Sbjct: 1577 RK 1578
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 178 bits (452), Expect = 4e-44
Identities = 258/1172 (22%), Positives = 502/1172 (42%), Gaps = 161/1172 (13%)
Query: 244 ESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELE-QMEIELKRLQQENMNLLSDA 302
E + ELA ++A+ R+ELEEK LL K +L+ Q++ E + L
Sbjct: 858 EDFERTKEELARSEAR----RKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLI 913
Query: 303 RSARMYRDELDALREKAVRVDKLESEV-----------SRYKERLHDIEFYKARVEELKE 351
+S + ++ L E+ +++ SE+ S K + D+E +VE+ K
Sbjct: 914 KSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKH 973
Query: 352 --DNQV--LLETKTMLEDQ------------------LEGTRARSDKLHELEKENLQLKA 389
+N+V L E T LE+ L+ + DK++ L K N +L+
Sbjct: 974 ATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQ 1033
Query: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQIS-----RTSELSE 444
+ D+E + ++K +L LE K S + + L + +QI + ELS+
Sbjct: 1034 QTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQ 1093
Query: 445 APQKSLGHEVNELTSSRLLK-LEMENQSLTKTVEELRTTVDSVEGNASKILK-MEKENQR 502
K +V+ L + +K L+ + L + +E T +E S + + +E+ ++R
Sbjct: 1094 LQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISER 1153
Query: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEH 562
L + +I K+ Q + +DL + Q E T TLR+ + L ++ ++
Sbjct: 1154 LEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDN 1213
Query: 563 LNQTVSSL-RQRSQISAE-----ARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKE 616
L + L +++S++ E + ++ + K + + + + S+I+ + Q +
Sbjct: 1214 LQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQL 1273
Query: 617 LEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLK 676
+ + R + EL H +E E L ++T K + LE+ ++E E +
Sbjct: 1274 IHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALT--QQLEELKRQMEEETKAKN 1331
Query: 677 KTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQ 736
+ ++ + L ++ + E EL+R +L A+ ++AQ + + E +
Sbjct: 1332 AMAHALQSSRHDCDLLREQYEEEQEAKAELQR---ALSKANSEVAQWRTKY-----ETDA 1383
Query: 737 LKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQ-QLESELQDLEMENQT 795
+++ EL +A K +RL+ + + + N + +LE + +++Q ++E ++DLE + T
Sbjct: 1384 IQRTEELEEAKKKLAQRLQEAEENTETANSKCA-SLEKTKQRLQGEVEDLMRDLE-RSHT 1441
Query: 796 LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
L+ K+ +K +Q+ + + + + +KE++ L + EE
Sbjct: 1442 ACATLD------KKQRNFDKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEV 1495
Query: 856 NVKIGNLEKENKTLSKEIGIYKESCV----RLKELEKENKELVKRATIDIK-TLVTLRED 910
++ L +ENK L +EI E L+E EK K+LV++ D++ L +
Sbjct: 1496 VDQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEK-TKKLVEQEKSDLQVALEEVEGS 1554
Query: 911 LVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDR-YKLLESKLESTLKK--- 966
L E+ K ++ +L ++ EL++ + K+ + + R + L+S L++ ++
Sbjct: 1555 LEHEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRND 1614
Query: 967 SLEIK---EEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPIS 1023
+L +K E + +E +L S + ++ L+TV+ + + D+ S
Sbjct: 1615 ALRLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALR-------S 1667
Query: 1024 GEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQIL 1083
ED +K++L VER N L E + +K L+Q E
Sbjct: 1668 NED----------------LKEQLAIVERRNGLLLEELEEMKVALEQTE----------- 1700
Query: 1084 ALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIK 1143
+T L EQ + +L L+SQ+TSL+N +L + + E E+ I+
Sbjct: 1701 ----RTRRLSEQELLDASDRVQL------LHSQNTSLINTKKKLEADIAQCQAEVENSIQ 1750
Query: 1144 EREDLKSLYDSLIKDHEKL--ELLHERQASEYESLISKH--GTLKS-AHKNLEVEHRDLE 1198
E + + I D + EL E+ S + + K+ T+K H+ E E L+
Sbjct: 1751 ESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALK 1810
Query: 1199 DRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1258
Q+ K + ++ +LE L VEQ++ AE K H Y + +K
Sbjct: 1811 GGKKQIQKLENRVRELENELDVEQKR-----------GAEALKGA-------HKYERKVK 1852
Query: 1259 E-TEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1317
E T + DHKN+ L Q ++ +K+K +Q + + N Q +++
Sbjct: 1853 EMTYQAEEDHKNILRL-------QDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQH 1905
Query: 1318 NLEE--ENRHLLD-QIQTLMLQNRTLLEQNME 1346
LEE E + + Q+ L ++R + Q ME
Sbjct: 1906 ELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
Score = 157 bits (397), Expect = 9e-38
Identities = 211/971 (21%), Positives = 436/971 (44%), Gaps = 134/971 (13%)
Query: 492 KILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSER 551
K + EKE + + E + E+ + + + + L++EK L+ +++ EN
Sbjct: 845 KSAEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETEN--- 901
Query: 552 QIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKR 611
+ E+ E L +S+I EA+VK+ L E ++E S++ +KR
Sbjct: 902 -LMDAEERCEGL--------IKSKILLEAKVKE-------LTERLEEEEEMNSELVAKKR 945
Query: 612 QIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERE 671
++ + K ++LE L +EKE + K+ NL E++ ALE+ S+L +E
Sbjct: 946 NLEDKCSSLKRD---IDDLELTLTKVEKEKHATENKVKNLS---EEMTALEENISKLTKE 999
Query: 672 NRKL----KKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLK--CASMKMAQLQL 725
+ L ++TLD + ++ L K N++L+++ +L ++E K A ++ A+ +L
Sbjct: 1000 KKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKL 1059
Query: 726 EN---------KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN 776
E +LE++K+Q++ E LK + +L+ + + + QK ++
Sbjct: 1060 EGDLKMSQESIMDLENDKQQIE---EKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQ 1116
Query: 777 KKIQQLESELQ-------DLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEK 829
+I++LE E++ +E + L + LEE+ S+RLE+ ++Q+E
Sbjct: 1117 ARIEELEEEIEAEHTLRAKIEKQRSDLARELEEI---SERLEEASGAT------SAQIEM 1167
Query: 830 DKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKE-LEK 888
+KK+ E E +++R+ ++++ TL ++ L K+ E+G ++ R+K+ LEK
Sbjct: 1168 NKKR-EAEFQKMRR--DLEEATL-QHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEK 1223
Query: 889 ENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQS 948
E EL ++I + + E L K ++ +E E++ + +L+HD
Sbjct: 1224 EKSEL----KMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNM 1279
Query: 949 TDDRYKLLESKLE----------STLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKT 998
R + +L S L KS + +++ L+ ++EE T + L++
Sbjct: 1280 QKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQS 1339
Query: 999 VKKNYEALKQRQDEER---------MVQSSPPISGEDNKWERESQETTREL----LKVKD 1045
+ + + L+++ +EE+ + +++ ++ K+E ++ + T EL K+
Sbjct: 1340 SRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1399
Query: 1046 RLIEVERNN-------ATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVS----LQE 1094
RL E E N A+L+ KQ L+ +++ L L ++ + L E
Sbjct: 1400 RLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAE 1459
Query: 1095 QNTTLQTQNAKL---QVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1151
L A+L Q E+ +L+++ + N +++ Q +L EN+++ +E DL
Sbjct: 1460 WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQ 1519
Query: 1152 YDSL---IKDHEKLELLHERQASEYE-SLISKHGTLKSAHKNLEVEHRDLE------DRY 1201
+++ EK + L E++ S+ + +L G+L+ H+ ++ LE +
Sbjct: 1520 IAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE--HEESKILRVQLELSQVKSELD 1577
Query: 1202 NQLLKQKGQLEDL----EKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLL 1257
+++++ ++E L ++ + Q + E ++ KK+ G+ LN QL
Sbjct: 1578 RKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGD---LNEMEIQLG 1634
Query: 1258 KETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKG 1317
+ K+L+++ K Q L+ ++ +QL I + E L ++K
Sbjct: 1635 HSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKV 1694
Query: 1318 NLEEENR-------HLL---DQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRR 1367
LE+ R LL D++Q L QN +L+ + + Q + + + E R
Sbjct: 1695 ALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVENSIQESRN 1754
Query: 1368 QKEKLEEKIMD 1378
+EK ++ I D
Sbjct: 1755 AEEKAKKAITD 1765
Score = 134 bits (338), Expect = 6e-31
Identities = 204/936 (21%), Positives = 394/936 (42%), Gaps = 113/936 (12%)
Query: 664 ENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQL 723
+++E E+E +K+ + K +L E +L+E+ + L + L+ Q+
Sbjct: 845 KSAEAEKEMATMKEDFERTKE---ELARSEARRKELEEKMVSLLQEKNDLQL------QV 895
Query: 724 QLENKEL---ESEKEQLKKGLELLKASFKK-TERLEVSYQGLDIENQRLQKTLENSNKKI 779
Q E + L E E L K LL+A K+ TERLE + N L N K
Sbjct: 896 QSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEE----MNSELVAKKRNLEDKC 951
Query: 780 QQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLE---- 835
L+ ++ DLE+ TL K +E + +++ L +E +LE+ S+L K+KK L+
Sbjct: 952 SSLKRDIDDLEL---TLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEAHQ 1008
Query: 836 -----------------KENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKE 878
K N +L QQ + + +LE+ +LE+ + L ++ + +E
Sbjct: 1009 QTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQE 1068
Query: 879 SCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLN 938
S + L+ +++ +E +K+ ++ L +D E++ + Q +++L +E++
Sbjct: 1069 SIMDLENDKQQIEEKLKKKEFELSQLQAKIDD---EQVHSLQFQKKIKELQARIEEL--- 1122
Query: 939 KERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYN---QQLRQE 995
E + E + + + S L L++ E EE A A++E + Q++R++
Sbjct: 1123 -EEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMRRD 1181
Query: 996 LKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNA 1055
L+ +EA ++ S + + + +R Q+ +E ++K + ++ N
Sbjct: 1182 LEEATLQHEATAATL-RKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIE 1240
Query: 1056 TLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ---VENST 1112
L K ++ + +E Q + ++A+ + L Q LQTQN +L E +
Sbjct: 1241 ALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEKES 1300
Query: 1113 LNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASE 1172
L SQ T ++ Q L QQ LE + +E + ++ +L +LL E+ E
Sbjct: 1301 LISQLT----KSKQALTQQ--LEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEE 1354
Query: 1173 YESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNH 1232
E+ L A+ + E Q + E+LE+ K +++ +N
Sbjct: 1355 QEAKAELQRALSKANSEVAQWRTKYETDAIQ------RTEELEEAKKKLAQRLQEAEENT 1408
Query: 1233 ETVAAEYKKLCGENDRLNHTYSQLLKETE-------VLQTDHKNLKSLLNNSKLEQTRLE 1285
ET ++ L RL L+++ E L +N +L K + +
Sbjct: 1409 ETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQ 1468
Query: 1286 AEFSKLKEQYQQLDITSTKLNN-------QCELLSQLKGNLEEENRHLLDQI-------- 1330
AE +++ + L K+ N Q E L + NL+EE L +QI
Sbjct: 1469 AELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIAETGKNLQ 1528
Query: 1331 -----QTLMLQNRTLLEQNMESKD--LFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFY 1383
+ L+ Q ++ L+ +E + L H E + +L EL + K +L+ K++++ +
Sbjct: 1529 EAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL-ELSQVKSELDRKVIEKDEEI 1587
Query: 1384 D--PSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDS 1441
+ +R + + I+S+ D R ++K D +E +QL H + Q +
Sbjct: 1588 EQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKK------MEGDLNEMEIQLGHSNRQMA 1641
Query: 1442 SSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLA 1501
+ GQ K S + L LR+ K+++ RR+ + + ++ M +A
Sbjct: 1642 ETQKHLRTVQGQL----KDSQLHLD--DALRSNEDLKEQLAIVERRNGLLLEELEEMKVA 1695
Query: 1502 GQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAIN 1537
+ T T L + + R + L + +T+ IN
Sbjct: 1696 LEQTERTRRLSEQELLDASDRVQLLHSQ--NTSLIN 1729
Score = 99.8 bits (247), Expect = 2e-20
Identities = 137/642 (21%), Positives = 279/642 (43%), Gaps = 75/642 (11%)
Query: 213 ELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTE 272
+ EE++ L A S A S K + EL +AK K+ + QE EE TE
Sbjct: 1350 QYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEENTE 1409
Query: 273 QLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRY 332
+ +E +RLQ E +L+ D + LD +K DK+ +E +
Sbjct: 1410 ---TANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLD---KKQRNFDKVLAE---W 1460
Query: 333 KERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLH 392
K++L + + A +E +++++ L T L D+L L +EN L+ ++
Sbjct: 1461 KQKLDESQ---AELEAAQKESRSL---STELFKMRNAYEEVVDQLETLRRENKNLQEEIS 1514
Query: 393 DMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGH 452
D+ + K ++E E +K E L LE++ + E E+ +
Sbjct: 1515 DLTEQIAETGKNLQE-------AEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQL 1567
Query: 453 EVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILEN 512
E++++ S K+ +++ + + + ++++ ++ + RL KK+E N
Sbjct: 1568 ELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDLN 1627
Query: 513 EI-VQEKQSLQNCQNLSKDLMKEKAQLEKT----IETLRENSE--RQIKILEQEN----E 561
E+ +Q S + K L + QL+ + + LR N + Q+ I+E+ N E
Sbjct: 1628 EMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLE 1687
Query: 562 HLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEH 619
L + +L Q R++ +E + D ++LH + K+E + Q + E+E+
Sbjct: 1688 ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQAEVEN 1747
Query: 620 YKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTL 679
++ AE E +K IT+ + E+++ + ++ LER + L++T+
Sbjct: 1748 SIQESRNAE-------------EKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1794
Query: 680 DSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKE-QLK 738
K+L +L+ E+ +LK ++ +L+ +ELE+E + + K
Sbjct: 1795 ---KDLQHRLDEAEQ----------------LALKGGKKQIQKLENRVRELENELDVEQK 1835
Query: 739 KGLELLKASFKKTERL-EVSYQGLDIENQ--RLQKTLENSNKKIQQLESELQDLEMENQT 795
+G E LK + K ++ E++YQ + RLQ ++ K++ + + ++ E + T
Sbjct: 1836 RGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANT 1895
Query: 796 ----LQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQ 833
++ EL+ +++R + E + L ++ + K +
Sbjct: 1896 QLSRCRRVQHELEEAAERADIAESQVNKLRAKSRDVGSQKME 1937
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 177 bits (449), Expect = 9e-44
Identities = 279/1317 (21%), Positives = 555/1317 (42%), Gaps = 170/1317 (12%)
Query: 161 QEVTHNQENVF----DLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERD-----EHSETI 211
Q+ Q+ VF + +W + + +++ E L + + L +E + E E
Sbjct: 228 QQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287
Query: 212 IELSEERDGLHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKT 271
E EE L + ++ E R+ + + ++LR+E EE+
Sbjct: 288 RERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERR 347
Query: 272 EQLLDCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSR 331
EQ L +QE E+ E +L+R Q+E R + R E RE+ +R + R
Sbjct: 348 EQQLRREQEEERREQQLRREQEEE-------RREQQLRREQQLRREQQLR----REQQLR 396
Query: 332 YKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQL--EGTRARSDKLHELEKENLQLKA 389
+++L R ++L+ + Q+ E + E QL E R ++ HE E+ +LK
Sbjct: 397 REQQLR-------REQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK- 448
Query: 390 KLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKS 449
+ E RD +++ E E + K+ +E W + E E ++
Sbjct: 449 --REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQ 506
Query: 450 LGHEVNELTSSRLLKLEME---------NQSLTKTVEELRTTVDSVEGNASKILKMEKEN 500
L E E RL + E E Q L + EE R + ++ K L+ E+
Sbjct: 507 LRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL--LKREEEKRLEQERRE 564
Query: 501 QRLSKKVEILENEIV--QEKQSLQNCQNLSKDLMKEKAQLEKTIETL--RENSERQIKIL 556
QRL ++ E ++++ +E++ Q + ++ ++++ + E+ +E L E E+++K
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE-VERLEQEERREQRLKRE 623
Query: 557 EQENEHLNQTVSSLRQRSQISAEARVKDIE-KENKILHESIKETSSKLSKIEFEKRQIKK 615
E E E Q + S Q + + R + E +E ++ E +E + K E E+ + ++
Sbjct: 624 EPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ 683
Query: 616 ELEHYKEKGERAEELENEL----HHLEKENELLQKKI-------TNLKITCEKIEALEQE 664
EL +E+ + E +++ + LE E + Q K+ + E+ E +
Sbjct: 684 ELAE-EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRR 742
Query: 665 NSEL--ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQ 722
SEL + E R ++ + + F + +E S+ + L R + + ++ +
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802
Query: 723 LQLENKEL---ESEKEQLK-------KGLELLKAS-----FKKTERLEVSYQGLDIENQR 767
Q + E EKEQ + K L+ L+ ++ ++L+ GL + +R
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQER 862
Query: 768 LQKTLENSNKKIQ-QLESE--------------LQDLEMENQTLQKNLEELKISSK-RLE 811
+ + ++K + QLE E + L E Q LQ+ EEL+ + +
Sbjct: 863 RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRR 922
Query: 812 QLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAE---IKDTTLEENNVKIGNLEKENKT 868
+ E+E + E+E Q E+++ E+ KR RQ+ E KD L++ ++ E E +
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 869 LSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKL 928
+ Y+E +EL++E ++L LRE+ EK + Q+ E+
Sbjct: 983 RQEREKKYREE----EELQQEEEQL-------------LREE--REKRRRQEW----ERQ 1019
Query: 929 THELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNY 988
+ +++ +E+LL +E+ ++ +L E + + ++ L+ +EE++ E
Sbjct: 1020 YRKKDELQQEEEQLLREER---EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 989 NQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLI 1048
+Q R+E + +++ E L + + E+R Q E+ + ++E ++ RE + K R
Sbjct: 1077 ERQYRKE-EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE-EREKRRRQ 1134
Query: 1049 EVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV 1108
E+ER + E Q + QL + E + Q + + QE+ L+ + K +
Sbjct: 1135 ELERQYRE-EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193
Query: 1109 ENSTLNSQSTSLMNQNAQLLI----QQSSL----ENENESVI---------KEREDLKSL 1151
E + L Q + Q+S L E E E+ + +E E + L
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253
Query: 1152 YDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL 1211
DS ++D + + + + L+ + + + RD + L+++ Q
Sbjct: 1254 EDSQLRDRQSQQ--------DLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQK 1305
Query: 1212 EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEV-----LQTD 1266
E + K ++EK LL + E K+ E DR QLL+E E + D
Sbjct: 1306 EAKRRDRKSQEEKQLLREEREE------KRRRQETDRKFREEEQLLQEREEQPLRRQERD 1359
Query: 1267 HKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQC-ELLSQLKGNLEEENRH 1325
K + L + + + LE E +L+ Q ++ + +C E QL+ ++ +R
Sbjct: 1360 RKFREEELRHQEQGRKFLEEE-QRLRRQERERKFLKEEQQLRCQEREQQLR---QDRDRK 1415
Query: 1326 LLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKL---EEKIMDQ 1379
++ Q L Q R + E + +R+++++ +LR+++ + EE+++ +
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472
Score = 169 bits (427), Expect = 3e-41
Identities = 248/1251 (19%), Positives = 521/1251 (41%), Gaps = 151/1251 (12%)
Query: 238 PGMKRTESRQHLSVELADAKAK------------------IRRLRQELEEKTE------Q 273
PG +R + RQ ELA+ + + + R RQE +E+ E Q
Sbjct: 133 PGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQ 192
Query: 274 LLDCK----------QELEQMEI-ELKRLQQENMNLLSDARSARMYRDELD---ALREKA 319
L CK ++L + E+ EL+R +E R R++++E + RE
Sbjct: 193 LQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETV 252
Query: 320 VR--VDKLESEVSRYKERLHDIE--FYKARVEELKEDNQVLLETKTMLEDQLEGTRARSD 375
+R +KL+ E + + L + E K +EL+ + Q + + L + + R + +
Sbjct: 253 LRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEE 312
Query: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELE- 434
+ E ++E + + + E R+ ++ +E E +++ ++ L E E
Sbjct: 313 ERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEER 372
Query: 435 ---QISRTSELSEAPQKSLGHEV---NELTSSRLLKLEMENQSLTKTVEELRTTVDSVEG 488
Q+ R +L Q ++ +L + L+ E + + + E + + E
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Query: 489 NASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLREN 548
+ + E+ QRL ++ E + + +E+++ ++ Q + K QL++ E E
Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE------RRKQQLKRDQE--EER 484
Query: 549 SERQIKILEQE-NEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIE 607
ER +K+ E+E E + LR+ + E R+K E+E ++ E + + E
Sbjct: 485 RERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEE 544
Query: 608 FEKRQIKKELEHYKEKGERAEELENELHH-----LEKENELLQKKI-------TNLKITC 655
++ +K+E E E+ R + L+ E L++E E Q+++ ++
Sbjct: 545 RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604
Query: 656 EKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKE---NSQLDEENLE-----LR 707
E++E LEQE ER ++LK+ + L+S E+E QL E E L+
Sbjct: 605 EEVERLEQE----ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 708 RNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTE-RLEVSYQGLDIE-- 764
R E + + + E +E E +E+ ++ E +K+ K + +LE +
Sbjct: 661 REEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY 720
Query: 765 ----NQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELK-----------ISSKR 809
Q Q+ + +K ++ ESELQ E E Q+ EE + S +
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERG 780
Query: 810 LEQLEKENKSLEQETSQLEKDKKQL----------EKENKRLRQQAEIKDTTLEENNVKI 859
++L EQ QL +++Q EKE +R +++ K+ E ++
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840
Query: 860 GNLEKENKTLSKEIGIYKESCVRLKELEKEN-------KELVKRATIDIKTLVTLREDLV 912
E+ + +E G+ ++ R + ++ + +E KR + L+E L
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 913 SEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKE 972
E+ Q+ +L++ E + + + +EQ + +LL + E ++ E +
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Query: 973 EKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERE 1032
K L+ + E+ + R+ + KK E + +Q+EE++++ +WER+
Sbjct: 961 RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE-KRRRQEWERQ 1019
Query: 1033 SQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSL 1092
++ EL + +++L+ ER LQ E++ + ++L+ + + Q+L +R+T
Sbjct: 1020 YRKKD-ELQQEEEQLLREEREKRRLQ-ERERQYREEEELQQE----EEQLLGEERETRRR 1073
Query: 1093 QEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLI-QQSSLENENESVIKEREDLKSL 1151
QE + + Q E L + Q + ++ L+ E E +++E + +
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR- 1132
Query: 1152 YDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHR---DLEDRYNQLLKQK 1208
+ + + E + + E + + K + LE ++R +L+ QLL+++
Sbjct: 1133 -----RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREE 1187
Query: 1209 GQLEDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHK 1268
+ E+ + +E+ L K K+ + D+ + Q E E D+K
Sbjct: 1188 QEKRRQERERQYREEEELQRQKR--------KQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239
Query: 1269 NLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLD 1328
N + Q E S+L+++ Q D+ Q Q + ++ +RH +
Sbjct: 1240 VYCKGRENEQFRQ----LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE 1295
Query: 1329 QIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQ 1379
+ Q + + ++ +S+ E++Q + + E +R++++ + K ++
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQ-----EEKQLLREEREEKRRRQETDRKFREE 1341
Score = 161 bits (408), Expect = 5e-39
Identities = 280/1361 (20%), Positives = 555/1361 (40%), Gaps = 199/1361 (14%)
Query: 161 QEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIELSEERDG 220
Q++ +QE +W++ + +E+ + L+R E++E E ++ EE +
Sbjct: 474 QQLKRDQEEERRERWLK---LEEEERREQQERREQQLRR---EQEERREQRLKRQEEEER 527
Query: 221 LHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQE 280
L S Q +R + + + + + + +RL++E EE+ +QLL K+E
Sbjct: 528 LQ---QRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL--KRE 582
Query: 281 LEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKL---ESEVSRYKERLH 337
E+ + LKR Q+E + R+ R+E++ L ++ R +L E E R ++ L
Sbjct: 583 EERRQQRLKREQEERLE-------QRLKREEVERLEQEERREQRLKREEPEEERRQQLLK 635
Query: 338 DIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEME 397
E + R ++L+ + Q E + E++ E R + HE E+ +L + + E
Sbjct: 636 SEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARE 695
Query: 398 R----------------------------------------DMDRKKIEELM--EENMTL 415
R + R++ EL EE
Sbjct: 696 RIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAH 755
Query: 416 EMAQKQSMDESLHLGWELEQ--------ISRTSELSEAPQKSLGHEVNELTSSRLLKLEM 467
Q++ W+ E+ +S L E ++ L E + R L E
Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEE 815
Query: 468 ENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNL 527
E + + E + +E ++ + E+ Q ++ + E++ + Q + Q
Sbjct: 816 EKEQRRRQRREREKELQFLE-EEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKW 874
Query: 528 SKDLMKEKAQLEKTI---ETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKD 584
L +E+ + T+ L+E ++ ++L++E E L + R+R + + R ++
Sbjct: 875 RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE 934
Query: 585 I--EKENKILHES------------------IKETSSKLSKIEFEKRQIKKELEHYKEKG 624
++E ++L E +++ +L E EKR+ ++ + Y+E+
Sbjct: 935 QLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE 994
Query: 625 ERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKN 684
E +E E +L E+E Q+ + K + L+QE +L RE R+ K+ L +
Sbjct: 995 ELQQE-EEQLLREEREKRRRQEWERQYR----KKDELQQEEEQLLREERE-KRRLQERER 1048
Query: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744
+ E L++E QL E E RR E L+ K +LQ E ++L E+ + ++ E
Sbjct: 1049 QYREEEELQQEEEQLLGEERETRRRQE-LERQYRKEEELQQEEEQLLREEPEKRRRQERE 1107
Query: 745 KASFKKTERLEVSYQGLDIENQ-RLQKTLENS---NKKIQQLESEL----------QDLE 790
+ ++ E + Q L E + R ++ LE +++QQ E +L Q+LE
Sbjct: 1108 RQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 791 M---ENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKR--LRQQA 845
E + LQ+ E+L + + E+E + E+E Q +K K++ E++R L+ Q
Sbjct: 1168 RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQW 1227
Query: 846 E-IKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTL 904
E K+ + +N V E E + ++S +R ++ +++ + L+
Sbjct: 1228 EPEKENAVRDNKVYCKGRENE------QFRQLEDSQLRDRQSQQDLQHLLGEQQ------ 1275
Query: 905 VTLREDLVSEKLKTQQMNN---DLEKLTHELEKIGLNKER-------LLHDE-------Q 947
D E+ + QQ + + E+L E +K ++R LL +E Q
Sbjct: 1276 ---ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQ 1332
Query: 948 STDDRYK----LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY 1003
TD +++ LL+ + E L++ + ++ K E R +E + Q L+ ++
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRR--QERDRKFREEELRHQEQGRKFLEEEQRLRRQERER 1390
Query: 1004 EALKQRQDEERMVQSSPPISGEDNKWERES-----QETTRELLKVKDRLIEVERNNATLQ 1058
+ LK+ Q + D K+ E QE R+ + + ++ ER L+
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE 1450
Query: 1059 AEKQALKTQLKQLETQNNNLQ---AQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNS 1115
E+Q + + ++ + LQ Q L Q + E+ L+ Q + L S
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510
Query: 1116 Q--STSLMNQNAQLLIQQSS---LENENESVIKER-EDLKSLYDSLIKDHEKLELLHERQ 1169
Q + + QL QQ L+ E + +ER + + D ++ E+L E Q
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQ 1570
Query: 1170 ASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLE-DLEKMLKVEQEKMLLE 1228
+ K + + E E + +ED QL +Q+GQ + E+ K +++ LL+
Sbjct: 1571 QLSRQERDRKFRLEEQKVRRQEQERKFMEDE-QQLRRQEGQQQLRQERDRKFREDEQLLQ 1629
Query: 1229 NKNHETVAAEYK------------------KLCGENDRLNHTYSQLLKETEVLQTDHKNL 1270
+ + + + + +L + DR QLL+E E Q +
Sbjct: 1630 EREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQER 1689
Query: 1271 KSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQI 1330
+ + R E E L+E+ Q + +L + QL+ E+E ++
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQEEQQ---LRRQELERKFREEEQLRQETEQEQLRRQERY 1746
Query: 1331 QTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEK 1371
+ ++ + + L E + L E+ + + +LR+++E+
Sbjct: 1747 RKILEEEQ--LRPEREEQQLRRQERDRKFREEEQLRQEREE 1785
Score = 144 bits (364), Expect = 6e-34
Identities = 242/1167 (20%), Positives = 491/1167 (42%), Gaps = 138/1167 (11%)
Query: 202 DERDEHSETIIELSEERDGLHFLPHASSSAQSPCGSPGMKRTES----RQHLSVELADAK 257
+E+ + E +L EE DGL S + + E R+H +
Sbjct: 837 EEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ 896
Query: 258 AKIRRLRQELEEKTEQLLD------CKQELEQMEIELKRLQQENMNLLSDARSARMYRDE 311
++R+ +Q L+E+ E+L +QE E+ E ++LQQE LL + R R ++
Sbjct: 897 EQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQE- 955
Query: 312 LDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEE----LKEDNQVLLETKTMLEDQL 367
RE+ R DK ++ + +E+L E K R +E +E+ ++ E + +L ++
Sbjct: 956 ----RERQYRKDK---KLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 368 EGTRARS-----DKLHELEKENLQLKAKLHDME--MERDMDRKKIEELMEENMTL----- 415
E R + K EL++E QL + + ER+ ++ EEL +E L
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEER 1068
Query: 416 EMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKT 475
E ++Q ++ EL+Q L E P+K E E +L+ E + L +
Sbjct: 1069 ETRRRQELERQYRKEEELQQ-EEEQLLREEPEKRRRQE-RERQCREEEELQQEEEQLLRE 1126
Query: 476 VEELRTTVDSVEGNASKILKMEKENQ-RLSKKVEILENEIVQEKQSLQNCQNLSKDLMKE 534
E R + E E Q R ++V+ E ++++E+ + Q L + +E
Sbjct: 1127 EREKRR-------------RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 535 KAQLEKTIETLRENSERQIKILEQ---ENEHLNQTVSSLRQRSQISAEARVK---DIEKE 588
+ ++ + LRE E++ + E+ E E L + R R + + +K + EKE
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE-DQRSDLKWQWEPEKE 1232
Query: 589 NKILHESI------KETSSKLSKIEFEKRQIKKELEHYK-EKGERAEELENEL-----HH 636
N + + E +L + RQ +++L+H E+ ER E E H
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292
Query: 637 LEKENELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKEN 696
+E +L +++ K K + +Q E E R+ ++T F+ L+ E++
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQP 1352
Query: 697 SQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEV 756
+ E + + R + K + + + E E++ LK+ +L + ER +
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQL-----RCQEREQQ 1407
Query: 757 SYQGLD--IENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLE 814
Q D + Q + + ++K ++ E +++ E E + L+ EE ++ +R +
Sbjct: 1408 LRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE---EEQQLRQERHRKFR 1464
Query: 815 KENKSL----EQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLS 870
+E + L EQ+ + E+D+K LE+E + RQ+ +D E ++ + E E K L
Sbjct: 1465 EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE---RDRKFREQELR--SQEPERKFLE 1519
Query: 871 KEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTH 930
+E ++++ R ++ +E ++L ++ + R+ E+L+ ++ L +
Sbjct: 1520 EEQQLHRQQ--RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQER 1577
Query: 931 ELEKIGLNKERLLHDEQST---DDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 987
+ K L ++++ EQ +D +L + + L++ + K + L EE
Sbjct: 1578 D-RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Query: 988 YNQ-----------QLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQET 1036
+ Q QLR++ + + ++ ++ ++EE+++Q GE+ + R QE
Sbjct: 1637 HRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQ-----EGEEQQLRR--QER 1689
Query: 1037 TRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNL-----QAQILALQRQTVS 1091
R+ + + +L ER LQ E+Q + +L++ + L Q Q+ +R
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKI 1749
Query: 1092 LQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSL 1151
L+E+ + + +L+ + + + Q + +Q E++ +E E L+
Sbjct: 1750 LEEEQLRPEREEQQLRRQERDRKFREEEQLRQERE---EQQLRSQESDRKFREEEQLR-- 1804
Query: 1152 YDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL 1211
++ E+ +L +++ +Y + LE + + L ++ + + Q
Sbjct: 1805 -----QEREEQQLRPQQRDGKYR--------WEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851
Query: 1212 EDLEKMLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKET-EVLQTDHKNL 1270
EK + EQE L + + + +KL E+ R Q ++ E+ + K
Sbjct: 1852 ATQEKSRREEQE--LWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGH 1909
Query: 1271 KSLLNNSKLEQTRLEAEFSKLKEQYQQ 1297
LL + + S L E Q+
Sbjct: 1910 GRLLEPGTHQFASVPVRSSPLYEYIQE 1936
Score = 77.0 bits (188), Expect = 2e-13
Identities = 137/639 (21%), Positives = 262/639 (41%), Gaps = 82/639 (12%)
Query: 773 ENSNKKIQQLESELQDLEMEN-----QTLQKNLEELKISSKRLEQLEKENKSLEQETSQ- 826
E + ES LQD E + + LEE +R ++ E+E + E E
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 827 -----LEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV 881
++D+++ ++E R RQ+ + ++ E E + E + + +
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELL 216
Query: 882 RLKELEKENKELVKRATID-----------IKTLVTLR---EDLVSEKLKTQQMNNDLEK 927
L+ +E K+ +R D K LR E L E+ + Q+ + E+
Sbjct: 217 ELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEE 276
Query: 928 LTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTN 987
+LE+ L +ER +E+ R + + ++ E +EE+ E R ++
Sbjct: 277 QLRKLERQELRRER--QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334
Query: 988 YNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRL 1047
QQLR+E + ++ + L++ Q+EER Q + E + RE Q + L+ + +L
Sbjct: 335 REQQLRREQE--ERREQQLRREQEEERREQQ---LRREQEEERREQQLRREQQLRREQQL 389
Query: 1048 IEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQ 1107
R L+ E+Q + Q + E Q Q L+R+ +EQ Q + +
Sbjct: 390 ----RREQQLRREQQLRREQQLRREQQLRREQ----QLRREQQLRREQEEERHEQKHEQE 441
Query: 1108 VENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEK------ 1161
L + ++ L+ E E+ ER + + L +D E+
Sbjct: 442 RREQRLKREQEE----------RRDWLKREEET---ERHEQERRKQQLKRDQEEERRERW 488
Query: 1162 LELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQL-----EDLEK 1216
L+L E + + E + + + ++ ++ E+R Q L+ + QL E E+
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 1217 MLKVEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNN 1276
+LK E+EK L + + + + E ++ QLLK E + + LK
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEE----------RRDQLLKREE--ERRQQRLKR-EQE 595
Query: 1277 SKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQ 1336
+LEQ RL+ E + EQ ++ + + + E QL + E+E R + Q L +
Sbjct: 596 ERLEQ-RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER----RQQQLRRE 650
Query: 1337 NRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEK 1375
+ EQ ++ ++ +++ + E RR++E EE+
Sbjct: 651 QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE 689
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.124 0.322
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,404,743
Number of Sequences: 37866
Number of extensions: 2932771
Number of successful extensions: 61016
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 814
Number of HSP's successfully gapped in prelim test: 1711
Number of HSP's that attempted gapping in prelim test: 15230
Number of HSP's gapped (non-prelim): 16152
length of query: 1870
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1753
effective length of database: 13,817,196
effective search space: 24221544588
effective search space used: 24221544588
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.