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Search of human proteins with 206597556
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|206597556 kelch domain containing 7B [Homo sapiens]
(594 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|206597556 kelch domain containing 7B [Homo sapiens] 1217 0.0
gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo... 313 4e-85
gi|116089333 kelch domain containing 7A [Homo sapiens] 299 4e-81
gi|55749726 kelch domain containing 5 [Homo sapiens] 125 1e-28
gi|38194229 kelch-like 17 [Homo sapiens] 96 1e-19
gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo... 95 2e-19
gi|157384932 hypothetical protein LOC390594 [Homo sapiens] 94 5e-19
gi|23397572 kelch-like 34 [Homo sapiens] 87 6e-17
gi|128485503 kelch-like 30 [Homo sapiens] 87 6e-17
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 84 3e-16
gi|24475847 influenza virus NS1A binding protein [Homo sapiens] 82 1e-15
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 79 2e-14
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 79 2e-14
gi|55925604 kelch-like 18 [Homo sapiens] 78 2e-14
gi|31542246 kelch-like 36 [Homo sapiens] 78 2e-14
gi|88196794 kelch-like 35 [Homo sapiens] 78 3e-14
gi|55925608 kelch-like 21 [Homo sapiens] 78 3e-14
gi|158508542 kelch-like 33 [Homo sapiens] 77 6e-14
gi|40807500 kelch-like 20 [Homo sapiens] 76 1e-13
gi|14780904 kelch-like 1 protein [Homo sapiens] 75 2e-13
gi|45643138 kelch-like 13 [Homo sapiens] 75 2e-13
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 74 3e-13
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 74 3e-13
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 74 3e-13
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 73 6e-13
gi|24308181 kelch-like 9 [Homo sapiens] 73 8e-13
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 71 2e-12
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 71 2e-12
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 71 2e-12
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 71 2e-12
>gi|206597556 kelch domain containing 7B [Homo sapiens]
Length = 594
Score = 1217 bits (3148), Expect = 0.0
Identities = 594/594 (100%), Positives = 594/594 (100%)
Query: 1 MVLRSHPFPRQDRPQGSVPRAVPGSPVGPSTSTHSEDRHGPSSSVGTVIGTGTGGLVEAG 60
MVLRSHPFPRQDRPQGSVPRAVPGSPVGPSTSTHSEDRHGPSSSVGTVIGTGTGGLVEAG
Sbjct: 1 MVLRSHPFPRQDRPQGSVPRAVPGSPVGPSTSTHSEDRHGPSSSVGTVIGTGTGGLVEAG 60
Query: 61 GQPQPRSSETNGSPSPDPPPGLRGEGTREKSLDPLPQAAMPRGPAQPPAQRPPGPAASSS 120
GQPQPRSSETNGSPSPDPPPGLRGEGTREKSLDPLPQAAMPRGPAQPPAQRPPGPAASSS
Sbjct: 61 GQPQPRSSETNGSPSPDPPPGLRGEGTREKSLDPLPQAAMPRGPAQPPAQRPPGPAASSS 120
Query: 121 ARRSQPVPQLRKRSRCEIAPSSEQEVRPAASGDPQGEAPGEGGSPAGRSGALTEKQEEAR 180
ARRSQPVPQLRKRSRCEIAPSSEQEVRPAASGDPQGEAPGEGGSPAGRSGALTEKQEEAR
Sbjct: 121 ARRSQPVPQLRKRSRCEIAPSSEQEVRPAASGDPQGEAPGEGGSPAGRSGALTEKQEEAR 180
Query: 181 KLMVFLQRPGGWGVVEGPRKPSSRALEPATAAALRRRLDLGSCLDVLAFAQQHGEPGLAQ 240
KLMVFLQRPGGWGVVEGPRKPSSRALEPATAAALRRRLDLGSCLDVLAFAQQHGEPGLAQ
Sbjct: 181 KLMVFLQRPGGWGVVEGPRKPSSRALEPATAAALRRRLDLGSCLDVLAFAQQHGEPGLAQ 240
Query: 241 ETYALMSDNLLRVLGDPCLYRRLSAADRERILSLRTGRGRAVLGVLVLPSLYQGGRSGLP 300
ETYALMSDNLLRVLGDPCLYRRLSAADRERILSLRTGRGRAVLGVLVLPSLYQGGRSGLP
Sbjct: 241 ETYALMSDNLLRVLGDPCLYRRLSAADRERILSLRTGRGRAVLGVLVLPSLYQGGRSGLP 300
Query: 301 RGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAG 360
RGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAG
Sbjct: 301 RGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAG 360
Query: 361 GIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGECLYSMEC 420
GIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGECLYSMEC
Sbjct: 361 GIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGECLYSMEC 420
Query: 421 YDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRLLRYSPVKDAWDECPYSA 480
YDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRLLRYSPVKDAWDECPYSA
Sbjct: 421 YDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRLLRYSPVKDAWDECPYSA 480
Query: 481 SHRRSSDIVALGGFLYRFDLLRGVGAAVMRYNTVTGSWSRAASLPLPAPAPLHCTTLGNT 540
SHRRSSDIVALGGFLYRFDLLRGVGAAVMRYNTVTGSWSRAASLPLPAPAPLHCTTLGNT
Sbjct: 481 SHRRSSDIVALGGFLYRFDLLRGVGAAVMRYNTVTGSWSRAASLPLPAPAPLHCTTLGNT 540
Query: 541 IYCLNPQVTATFTVSGGTAQFQAKELQPFPLGSTGVLSPFILTLPPEDRLQTSL 594
IYCLNPQVTATFTVSGGTAQFQAKELQPFPLGSTGVLSPFILTLPPEDRLQTSL
Sbjct: 541 IYCLNPQVTATFTVSGGTAQFQAKELQPFPLGSTGVLSPFILTLPPEDRLQTSL 594
>gi|7662260 kelch repeat and BTB (POZ) domain containing 11 [Homo
sapiens]
Length = 623
Score = 313 bits (801), Expect = 4e-85
Identities = 227/620 (36%), Positives = 298/620 (48%), Gaps = 73/620 (11%)
Query: 11 QDRPQGSVPRAVPGSPVGPSTSTHSEDRHGPSSSVGTVIGTGTGGLVEAGGQPQPRSSET 70
+ +G+ A +G S S + P S G T G + R E
Sbjct: 21 ESESEGAASPAQTPCSLGASLCFSSGEESPPQSLASAAEGAATSPPSSGGPRVVERQWEA 80
Query: 71 N--GSPSPDPPPGLRGEGTREKSLDPLPQAAM----PRGPAQP--PAQRPPG-PAASSSA 121
G+ SP+ E+ P P+ + P P +P PA PPG A
Sbjct: 81 GSAGAASPEELASPEERACPEEPAAPSPEPRVWLEDPASPEEPGEPAPVPPGFGAVYGEP 140
Query: 122 RRSQPVPQLRKRSRCEIAPSSEQEVRPAASGDP---QGE---------APGEGGSPAG-R 168
V R R+ + + R AS D QG A G AG R
Sbjct: 141 DLVLEVSGRRLRAHKAVLAARSDYFRARASRDVLRVQGVSLTALRLLLADAYSGRMAGVR 200
Query: 169 SGALTEKQEEARKLMVFLQRPGGWGVVEGPRKPSSRALEPATAAALRRRLDLGSCLDVLA 228
+ E AR+L Q PG + RA + A+ +L L +C +VL+
Sbjct: 201 PDNVAEVVAGARRL----QLPGA----------AQRATD-----AVGPQLSLANCYEVLS 241
Query: 229 FAQQHGEPGLAQETYALMSDNLLRVLGDPCLYRRLSAADRERILSLRTGRGRAVLGVLVL 288
A++ L Y MSD+ L VL +P ++ RLS A+R+ +L R GRA L L
Sbjct: 242 AAKRQRLNELRDAAYCFMSDHYLEVLREPAVFGRLSGAERDLLLRRRLRAGRAHLLAAAL 301
Query: 289 PSLYQGGRSGLPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCG 348
G +G G R + P A A ++ F+ WR LT++PE AP RGCG
Sbjct: 302 ------GPAGERAGSRPQSPSGDADARGD--AAVYCFHAAAGEWRELTRLPEGAPARGCG 353
Query: 349 LCTMHNYLFLAGGIRGSG--AKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGL 406
LC ++NYLF+AGG+ +G +A S++VFCYNP T+ WS VRP++QAR+QL+L+ALDG
Sbjct: 354 LCVLYNYLFVAGGVAPAGPDGRARPSDQVFCYNPATDSWSAVRPLRQARSQLRLLALDGH 413
Query: 407 LYAIGGECLYSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRLLRY 466
LYA+GGECL S+E YDPR D W P APLP G F VAHEA C G+IYV+GG LFYRLL+Y
Sbjct: 414 LYAVGGECLLSVERYDPRADRWAPVAPLPRGAFAVAHEATTCHGEIYVSGGSLFYRLLKY 473
Query: 467 SPVKDAWDECPYSASHRRSSDIVALGGFLYRFDL--LRG-------VGAAVMRYNTVTGS 517
P +D W ECP S+S RS+D+VAL GF+YRFDL RG G +V RY+ +
Sbjct: 474 DPRRDEWQECPCSSSRERSADMVALDGFIYRFDLSGSRGEAQAAGPSGVSVSRYHCLAKQ 533
Query: 518 WSRAASLPLPAPA------PLHCTTLGNTIYCLNPQVTATF------TVSGGTAQFQAKE 565
WS + PL P P C L IYC++ T F G Q E
Sbjct: 534 WSPCVA-PLRLPGGPTGLQPFRCAALDGAIYCVSRAGTWRFQPAREGEAGGDAGQGGGFE 592
Query: 566 LQPFPLGSTGVLSPFILTLP 585
PL GVL PF L+LP
Sbjct: 593 ALGAPLDVRGVLIPFALSLP 612
>gi|116089333 kelch domain containing 7A [Homo sapiens]
Length = 777
Score = 299 bits (766), Expect = 4e-81
Identities = 200/534 (37%), Positives = 262/534 (49%), Gaps = 64/534 (11%)
Query: 61 GQPQPRSSETNGSPSPDPPPGLRGEGTREKSLDPLPQAAMPRGPAQPPAQRPPGPAASSS 120
G+ PR++ PSP PPPG G G QA +G A+ A GP S+
Sbjct: 304 GRLAPRTAALTEVPSPRPPPGSLGTGAASGG-----QAGDTKGAAERAASPQTGPWPSTR 358
Query: 121 ARRSQPVPQLRKRSRCEIAPSSEQEVRPAASGDPQGEAPGEGGSPA-GRSGALTEKQEEA 179
RK S +IA + E +++P P P G P GRS Q A
Sbjct: 359 GFS-------RKESLLQIAENPELQLQPDGFRLPAPPCPDPGALPGLGRSSREPHVQPVA 411
Query: 180 RKLMVFLQRPGGWGVVEGPRKPSSRALEPATAAALRRRLDLGSCLDVLAFAQQHGEPGLA 239
G P P+S A + RLDLG+C +VL A++ L
Sbjct: 412 -----------GTNFFHIPLTPAS---------APQVRLDLGNCYEVLTLAKRQNLEALK 451
Query: 240 QETYALMSDNLLRVLGDPCLYRRLSAADRERILSLRTGRGRAVLGVL-VLPSLYQGGRSG 298
+ Y +MS+N L+VL P +Y LS A+RE IL R RGR L V V P GG
Sbjct: 452 EAAYKVMSENYLQVLRSPDIYGCLSGAERELILQRRL-RGRQYLVVADVCPKEDSGG--- 507
Query: 299 LPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFL 358
L ++ ++ WRPL ++P EA RGC +C++ NYLF+
Sbjct: 508 -----------------------LCCYDDEQDVWRPLARMPPEAVSRGCAICSLFNYLFV 544
Query: 359 AGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGECLYSM 418
G +G G + S+ VFCYNPLT IWS+V P+ QAR +LVALDG LYAIGGECL S+
Sbjct: 545 VSGCQGPGHQP--SSRVFCYNPLTGIWSEVCPLNQARPHCRLVALDGHLYAIGGECLNSV 602
Query: 419 ECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRLLRYSPVKDAWDECPY 478
E YDPR D W PLP+ TF +AH A +I+VTGG L + L R+S + W P
Sbjct: 603 ERYDPRLDRWDFAPPLPSDTFALAHTATVRAKEIFVTGGSLRFLLFRFSAQEQRWWAGPT 662
Query: 479 SASHRRSSDIVALGGFLYRFDLLRGVGAAVMRYNTVTGSWSRAASLPLPAPAPLHCTTLG 538
S R++++VA+ GFLYRFDL R +G AV R + T W A+ P P C +
Sbjct: 663 GGSKDRTAEMVAVNGFLYRFDLNRSLGIAVYRCSASTRLWYECATYRTPYPDAFQCAVVD 722
Query: 539 NTIYCLNPQVTATFTVSGGTAQFQAKELQPFPLGSTGVLSPFILTLPPEDRLQT 592
N IYC+ + T F + +F KEL+ FP G L P +LTLP D QT
Sbjct: 723 NLIYCVGRRSTLCFLADSVSPRFVPKELRSFP-APQGTLLPTVLTLPTPDLPQT 775
>gi|55749726 kelch domain containing 5 [Homo sapiens]
Length = 505
Score = 125 bits (313), Expect = 1e-28
Identities = 107/356 (30%), Positives = 152/356 (42%), Gaps = 37/356 (10%)
Query: 214 LRRRLDLGSCLDVLAFAQQHGEPGLAQETYALMSDNLLRVLGDPCLYRRLSAADRERILS 273
L ++ L +CL++ AQ +G P L + M + VL P + S +S
Sbjct: 121 LLSQVRLNNCLEMYRLAQVYGLPDLQEACLRFMVVHFHEVLCKPQFHLLGSPPQAPGDVS 180
Query: 274 LRTG-RGRAVLGVLVLPSLYQGGRSGLPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENTW 332
L+ R + G VL +L L P EPP+ + W
Sbjct: 181 LKQRLREARMTGTPVLVALGDFLGGPLAPHPYQGEPPSMLR-----------YEEMTERW 229
Query: 333 RPLTQ--VPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRP 390
PL P+ +RG G + NYLF+ GG R + + ++ YNP TN W QV
Sbjct: 230 FPLANNLPPDLVNVRGYGSAILDNYLFIVGGYRITSQEISAAHS---YNPSTNEWLQVAS 286
Query: 391 MQQARAQLKLVALDGLLYAIGGECLYSMECYDPRTDAWTPRAPLPAGTFPVAH-EAVACR 449
M Q R+ KLVA++ LYAIGG+ + ++ECY+P DAW APLP P+A A C+
Sbjct: 287 MNQKRSNFKLVAVNSKLYAIGGQAVSNVECYNPEQDAWNFVAPLPN---PLAEFSACECK 343
Query: 450 GDIYVTGGHLF----YRLLRYSPVKDAWDECPYSASHRRSSDIVA-------LGGFLYRF 498
G IYV GG+ +L+Y P D W H R +V+ +GG L+
Sbjct: 344 GKIYVIGGYTTRDRNMNILQYCPSSDMWTLFETCDVHIRKQQMVSVEETIYIVGGCLHEL 403
Query: 499 DLLRGVGAA-----VMRYNTVTGSWSRAASLPLPAPAPLHCTTLGNTIYCLNPQVT 549
R + V YNTVT W + L C + IY ++ VT
Sbjct: 404 GPNRRSSQSEDMLTVQSYNTVTRQWLYLKENTSKSGLNLTCALHNDGIYIMSRDVT 459
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 95.5 bits (236), Expect = 1e-19
Identities = 65/216 (30%), Positives = 101/216 (46%), Gaps = 20/216 (9%)
Query: 320 AHLHVFNPRENTWRPLTQVPEEAPLRGC-GLCTMHNYLFLAGGIRGSGAKAVCSNEVFCY 378
A + ++P NTW+P + R C G+ +H L+ AGG G A C N Y
Sbjct: 404 ATVESYDPVTNTWQPEVSMGTR---RSCLGVAALHGLLYSAGGYDG----ASCLNSAERY 456
Query: 379 NPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPL 434
+PLT W+ V M R +++ LDG LYA+GG L ++E Y+P+ + W+P A +
Sbjct: 457 DPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEKYEPQVNVWSPVASM 516
Query: 435 PAGTFPVAHEAVACRGDIYVTGGH----LFYRLLRYSPVKDAWDECPYSASHRRSSDIVA 490
+ G +YV GG+ + RYSP AW+ R + D+VA
Sbjct: 517 LSRRSSAG--VAVLEGALYVAGGNDGTSCLNSVERYSPKAGAWESVAPMNIRRSTHDLVA 574
Query: 491 LGGFLYRFDLLRGVGA--AVMRYNTVTGSWSRAASL 524
+ G+LY G + ++ +YN T W A+ +
Sbjct: 575 MDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAASCM 610
Score = 61.2 bits (147), Expect = 3e-09
Identities = 49/172 (28%), Positives = 72/172 (41%), Gaps = 14/172 (8%)
Query: 364 GSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSME 419
G G+ + Y+ T+ W V M RA++ + A+ LYA+GG L ++E
Sbjct: 348 GGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRARVGVAAVGNRLYAVGGYDGTSDLATVE 407
Query: 420 CYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRLL----RYSPVKDAWDE 475
YDP T+ W P + GT A G +Y GG+ L RY P+ W
Sbjct: 408 SYDPVTNTWQPEVSM--GTRRSCLGVAALHGLLYSAGGYDGASCLNSAERYDPLTGTWTS 465
Query: 476 CPYSASHRRSSDIVALGGFLYR---FDLLRGVGAAVMRYNTVTGSWSRAASL 524
++ RR + L G LY +D + A V +Y WS AS+
Sbjct: 466 VAAMSTRRRYVRVATLDGNLYAVGGYDSSSHL-ATVEKYEPQVNVWSPVASM 516
>gi|51479184 kelch repeat and BTB (POZ) domain containing 1 [Homo
sapiens]
Length = 634
Score = 94.7 bits (234), Expect = 2e-19
Identities = 70/224 (31%), Positives = 100/224 (44%), Gaps = 32/224 (14%)
Query: 324 VFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEV--FC-YNP 380
++ EN W LT++P ++ C + M +L++AGG + A+ + V FC Y+P
Sbjct: 337 LYRDPENGWSKLTEMPAKS-FNQC-VAVMDGFLYVAGGEDQNDARNQAKHAVSNFCRYDP 394
Query: 381 LTNIWSQVRPMQQARAQLKLVALDGLLYAIGGE----CLYSMECYDPRTDAWTPRAPLPA 436
N W + M Q R L +GL+YA GG L S+ECY P T+ W P+ PL
Sbjct: 395 RFNTWIHLASMNQKRTHFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQWQPKTPLEV 454
Query: 437 GTFPVAHEAVACRGDIYVTGGHLFYRLLR----YSPVKDAWDECPYSASHRRSSDIVALG 492
H + G + VTGG++ R Y P D+W E P ++ R V L
Sbjct: 455 AR--CCHASAVADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGWHCAVTLS 512
Query: 493 GFLY------------RFDLLRGVGAAVMRYNTVTGSWSRAASL 524
+Y R D+L V Y+ TG WS AA L
Sbjct: 513 DRVYVMGGSQLGPRGERVDVL-----TVECYSPATGQWSYAAPL 551
Score = 50.1 bits (118), Expect = 6e-06
Identities = 35/126 (27%), Positives = 54/126 (42%), Gaps = 11/126 (8%)
Query: 325 FNPRENTWRPLTQVPEEAPLRG--CGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLT 382
++P ++W+ L P + RG C + + G G + V V CY+P T
Sbjct: 486 YDPASDSWQEL---PNLSTPRGWHCAVTLSDRVYVMGGSQLGPRGERVDVLTVECYSPAT 542
Query: 383 NIWSQVRPMQQARAQLKLVALDGLLYAIG----GECLYS--MECYDPRTDAWTPRAPLPA 436
WS P+Q + + AL G Y +G GE Y ++C+ P + WT LP
Sbjct: 543 GQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKKCIQCFSPELNEWTEDDELPE 602
Query: 437 GTFPVA 442
T V+
Sbjct: 603 ATVGVS 608
>gi|157384932 hypothetical protein LOC390594 [Homo sapiens]
Length = 458
Score = 93.6 bits (231), Expect = 5e-19
Identities = 93/309 (30%), Positives = 123/309 (39%), Gaps = 53/309 (17%)
Query: 310 AAAPVSLPLPAHLH-------VFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGI 362
AA P P L + E+ WR L +P EA G+ T+ N L++ GG+
Sbjct: 158 AAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGV 217
Query: 363 RGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGEC----LYSM 418
RG+ + V FCY+P W + Q R L DG LYAIGGE + S+
Sbjct: 218 RGASKEVV--ELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSV 275
Query: 419 ECYDPRTDAWTPRA--PLPAGTFPVAHEAVACRGDIYVTGGHLFYRLLR---------YS 467
E YDP W+ A P PA P A AC G LF L R Y+
Sbjct: 276 ERYDPAAGCWSFVADLPQPAAGVPCAQ---AC--------GRLFVCLWRPADTTAVVEYA 324
Query: 468 PVKDAWDEC-----PYSASH----RRSSDIVALGGFLYRFDLLRGVGAAVMRYNTVTGSW 518
DAW P S H R S V G F + A+ N TG W
Sbjct: 325 VRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGPSDDF-----LHCAIDCLNLATGQW 379
Query: 519 SRAASLPLPAPAPLHCTTL-GNTIYCLNPQVTATFTVSGGTAQFQAKELQPFPLGSTGVL 577
+ + + L + G+T+Y +N T + + GGT + +E FP G L
Sbjct: 380 TALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRL-LREKAGFP--RPGSL 436
Query: 578 SPFILTLPP 586
F+L LPP
Sbjct: 437 QTFLLRLPP 445
>gi|23397572 kelch-like 34 [Homo sapiens]
Length = 644
Score = 86.7 bits (213), Expect = 6e-17
Identities = 69/232 (29%), Positives = 104/232 (44%), Gaps = 29/232 (12%)
Query: 318 LPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKA-------- 369
L ++ F+ + WR LTQ+P PL G +CT N+LF+ GG SG+ +
Sbjct: 332 LTQNVVAFDVYNHRWRSLTQLP--TPLLGHSVCTAGNFLFVLGGESPSGSASSPLADDSR 389
Query: 370 VCSNEVFCYNPLTNIWSQVRPMQQARAQL-------KLVALDGLLYAIGGECLYSMECYD 422
V + +V Y+P + W++V M++ARA +L+A+ GL GGE L S+E YD
Sbjct: 390 VVTAQVHRYDPRFHAWTEVPAMREARAHFWCGAVGERLLAVGGL--GAGGEVLASVEMYD 447
Query: 423 PRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHL---------FYRLLRYSPVKDAW 473
R D WT LP A AV RG +Y++GG L P + W
Sbjct: 448 LRRDRWTAAGALPRALHGHA-GAVGDRGVVYISGGKAGRGEGGASSLRDLYVLGPEEQVW 506
Query: 474 DECPYSASHRRSSDIVALGGFLYRFDLLRGVGAAVMRYNTVTGSWSRAASLP 525
+ + R + L G ++ F + + RY+ W+R LP
Sbjct: 507 SKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSEIERYDPGADQWTRLRPLP 558
Score = 49.3 bits (116), Expect = 1e-05
Identities = 46/183 (25%), Positives = 71/183 (38%), Gaps = 19/183 (10%)
Query: 303 PRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGI 362
P G A S + A +H ++PR + W T+VP R C LA G
Sbjct: 376 PSGSASSPLADDSRVVTAQVHRYDPRFHAW---TEVPAMREARAHFWCGAVGERLLAVGG 432
Query: 363 RGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQA-RAQLKLVALDGLLYAIGGEC------- 414
G+G + + S E+ Y+ + W+ + +A V G++Y GG+
Sbjct: 433 LGAGGEVLASVEM--YDLRRDRWTAAGALPRALHGHAGAVGDRGVVYISGGKAGRGEGGA 490
Query: 415 --LYSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHL--FYRLLRYSPVK 470
L + P W+ +AP+ GT H RG ++ G F + RY P
Sbjct: 491 SSLRDLYVLGPEEQVWSKKAPM--GTARFGHHMAVLRGAVFAFLGRYEPFSEIERYDPGA 548
Query: 471 DAW 473
D W
Sbjct: 549 DQW 551
Score = 49.3 bits (116), Expect = 1e-05
Identities = 35/124 (28%), Positives = 54/124 (43%), Gaps = 6/124 (4%)
Query: 320 AHLHVFNPRENTWRPLTQVPEEAPLRG-CGLCTMHNYLFLAGGIRGSGAKAVCS-NEVFC 377
A + +++ R + W +P L G G ++++GG G G S +++
Sbjct: 441 ASVEMYDLRRDRWTAAGALPRA--LHGHAGAVGDRGVVYISGGKAGRGEGGASSLRDLYV 498
Query: 378 YNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG--ECLYSMECYDPRTDAWTPRAPLP 435
P +WS+ PM AR + L G ++A G E +E YDP D WT PLP
Sbjct: 499 LGPEEQVWSKKAPMGTARFGHHMAVLRGAVFAFLGRYEPFSEIERYDPGADQWTRLRPLP 558
Query: 436 AGTF 439
F
Sbjct: 559 YDRF 562
>gi|128485503 kelch-like 30 [Homo sapiens]
Length = 560
Score = 86.7 bits (213), Expect = 6e-17
Identities = 63/210 (30%), Positives = 90/210 (42%), Gaps = 18/210 (8%)
Query: 295 GRSGLPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHN 354
G L GEEP P + +N + W L P+ G L ++N
Sbjct: 257 GGQALEEEEAGEEPT-------PGLGNFAFYNSKAKRWMALPDFPDYHKW-GFSLAALNN 308
Query: 355 YLFLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGEC 414
+++ GG RG+ + + +C+ W V PM + R AL+G +Y IGG
Sbjct: 309 NIYVTGGSRGTKTDTWSTTQAWCFPLKEASWKPVAPMLKPRTNHASAALNGEIYVIGGTT 368
Query: 415 L--YSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGG----HLFYRLLRYSP 468
L +E YDP TD+WTP + PA + A CRG +Y+ G + L Y+P
Sbjct: 369 LDVVEVESYDPYTDSWTPVS--PALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCYNP 426
Query: 469 VKDAWD--ECPYSASHRRSSDIVALGGFLY 496
V DAW P+ + S AL G LY
Sbjct: 427 VTDAWSVIASPFLPKYLSSPRCAALHGELY 456
Score = 52.4 bits (124), Expect = 1e-06
Identities = 98/405 (24%), Positives = 145/405 (35%), Gaps = 59/405 (14%)
Query: 214 LRRRLDLGSCLDVLAFAQQHGEPGLAQETYALMSDNLLRVLGDPCLYRRLSAADRERILS 273
L+++LD +CL + F +Q G G+A + +A + +N V + RER+++
Sbjct: 108 LQQQLDAANCLGICEFGEQQGLLGVAAKAWAFLRENFEAVARED----EFLQLPRERLVT 163
Query: 274 LRTGRGRAVLGVLVLPSLYQGGRSGLPRGPRGEEPPAAA--PVSLPLPAHLHVFNPRENT 331
+ G L+ Q L R R + AA P L L HL PR
Sbjct: 164 -------CLAGDLLQVQPEQSRLEALMRWVRHDPQARAAHLPELLSL-VHLDAV-PRPCV 214
Query: 332 WRPLTQVP--EEAPLRGCGLCTMHN------------YLFLAGG------IRGSGAKAVC 371
+ L P +E+ L H+ L + GG G
Sbjct: 215 QQLLASEPLIQESEACRAALSQGHDGAPLALQQKLEEVLVVVGGQALEEEEAGEEPTPGL 274
Query: 372 SNEVFCYNPLTNIWSQVRPM-QQARAQLKLVALDGLLYAIGGE--------CLYSMECYD 422
N F YN W + + L AL+ +Y GG C+
Sbjct: 275 GNFAF-YNSKAKRWMALPDFPDYHKWGFSLAALNNNIYVTGGSRGTKTDTWSTTQAWCFP 333
Query: 423 PRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLF--YRLLRYSPVKDAWDECPYSA 480
+ +W P AP+ H + A G+IYV GG + Y P D+W P S
Sbjct: 334 LKEASWKPVAPMLKPR--TNHASAALNGEIYVIGGTTLDVVEVESYDPYTDSW--TPVSP 389
Query: 481 SHRRSSDIVALG--GFLYRF--DLLRGVGAAVMRYNTVTGSWSRAAS--LPLPAPAPLHC 534
+ + S+ A G G LY + A+ YN VT +WS AS LP +P C
Sbjct: 390 ALKYVSNFSAAGCRGRLYLVGSSACKYNALALQCYNPVTDAWSVIASPFLPKYLSSP-RC 448
Query: 535 TTLGNTIYCLNPQVTATFTVSGGTAQFQAKELQPFPLGSTGVLSP 579
L +Y + + G +Q + Q L G L P
Sbjct: 449 AALHGELYLIGDNTKKVYVYDPGANLWQKVQSQ-HSLHENGALVP 492
Score = 43.5 bits (101), Expect = 5e-04
Identities = 31/121 (25%), Positives = 44/121 (36%), Gaps = 16/121 (13%)
Query: 322 LHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPL 381
L +NP + W + L +H L+L G + +V+ Y+P
Sbjct: 421 LQCYNPVTDAWSVIASPFLPKYLSSPRCAALHGELYLIGDN---------TKKVYVYDPG 471
Query: 382 TNIWSQVRPMQQARAQLKLVALDGLLYAIG-------GECLYSMECYDPRTDAWTPRAPL 434
N+W +V+ LV L LY G G+ ME YD D WT L
Sbjct: 472 ANLWQKVQSQHSLHENGALVPLGDALYVTGGRWQGMEGDYHVEMEAYDTVRDTWTRHGAL 531
Query: 435 P 435
P
Sbjct: 532 P 532
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 84.3 bits (207), Expect = 3e-16
Identities = 61/211 (28%), Positives = 97/211 (45%), Gaps = 17/211 (8%)
Query: 322 LHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVC----SNEVFC 377
+ ++ P+ ++W L P P G+C + +++ GGI + V N V C
Sbjct: 301 VEMYFPQNDSWIGLA--PLNIPRYEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVEC 358
Query: 378 YNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAP 433
+NP TN W+ + M ++R+ L +V L G LYA+GG L S+E Y P+ W P AP
Sbjct: 359 WNPDTNTWTSLERMNESRSTLGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAP 418
Query: 434 LPAGTFPVAHEAVACRGDIYVTGGH---LFYRLLRYSPVKDAWDECPYSASHRRSSDIVA 490
+ T A G IY GG+ + RY P KD+W+ A R +
Sbjct: 419 MT--TTRSCFAAAVLDGMIYAIGGYGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGV 476
Query: 491 LGGFLYRFDLLRGVG--AAVMRYNTVTGSWS 519
+ GF++ GV +++ RY+ W+
Sbjct: 477 MLGFIFVVGGHNGVSHLSSIERYDPHQNQWT 507
Score = 53.1 bits (126), Expect = 7e-07
Identities = 32/121 (26%), Positives = 59/121 (48%), Gaps = 13/121 (10%)
Query: 319 PAHLHV---FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEV 375
PAH++ ++P +++W + + ++ G G+ M ++F+ GG G +
Sbjct: 443 PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGV--MLGFIFVVGGHNGVSHLSSIER-- 498
Query: 376 FCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGEC----LYSMECYDPRTDAWTPR 431
Y+P N W+ RPM++ R + +D LY +GG L +++ YDP +D W
Sbjct: 499 --YDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWLDS 556
Query: 432 A 432
A
Sbjct: 557 A 557
Score = 49.7 bits (117), Expect = 8e-06
Identities = 43/183 (23%), Positives = 67/183 (36%), Gaps = 25/183 (13%)
Query: 362 IRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGECL------ 415
+ G C + V Y P + W + P+ R + + LD +Y IGG
Sbjct: 288 VGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPRYEFGICVLDQKVYVIGGIATNVRPGV 347
Query: 416 ------YSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGH----LFYRLLR 465
S+EC++P T+ WT + + V G++Y GG+ + +
Sbjct: 348 TIRKHENSVECWNPDTNTWTSLERMNESRSTLG--VVVLAGELYALGGYDGQSYLQSVEK 405
Query: 466 YSPVKDAWDECPYSASHRRSSDIVALGGFLYRFDLLRGVGAA----VMRYNTVTGSWSRA 521
Y P W + R L G +Y + G G A V RY+ SW
Sbjct: 406 YIPKIRKWQPVAPMTTTRSCFAAAVLDGMIY---AIGGYGPAHMNSVERYDPSKDSWEMV 462
Query: 522 ASL 524
AS+
Sbjct: 463 ASM 465
Score = 49.7 bits (117), Expect = 8e-06
Identities = 39/155 (25%), Positives = 60/155 (38%), Gaps = 17/155 (10%)
Query: 327 PRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIWS 386
P+ W+P+ + R C + + + A G G N V Y+P + W
Sbjct: 408 PKIRKWQPVAPM---TTTRSCFAAAVLDGMIYAIG----GYGPAHMNSVERYDPSKDSWE 460
Query: 387 QVRPMQQARAQLKLVALDGLLYAIGGEC----LYSMECYDPRTDAWTPRAPLPAGTFPVA 442
V M R + + G ++ +GG L S+E YDP + WT P+ V
Sbjct: 461 MVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSSIERYDPHQNQWTVCRPMKEPRTGVG 520
Query: 443 HEAVACRGDIYVTGGH----LFYRLLRYSPVKDAW 473
A +YV GGH + +Y P+ D W
Sbjct: 521 --AAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTW 553
Score = 39.7 bits (91), Expect = 0.008
Identities = 24/79 (30%), Positives = 35/79 (44%), Gaps = 6/79 (7%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
++P +N W P + P G G + NYL++ GG GS N V Y+P+++
Sbjct: 499 YDPHQNQWTVCR--PMKEPRTGVGAAVIDNYLYVVGGHSGSSYL----NTVQKYDPISDT 552
Query: 385 WSQVRPMQQARAQLKLVAL 403
W M R L AL
Sbjct: 553 WLDSAGMIYCRCNFGLTAL 571
>gi|24475847 influenza virus NS1A binding protein [Homo sapiens]
Length = 642
Score = 82.0 bits (201), Expect = 1e-15
Identities = 66/236 (27%), Positives = 96/236 (40%), Gaps = 25/236 (10%)
Query: 305 GEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRG 364
G P ++P S P + F +++ P + G G M+ L AGG
Sbjct: 319 GRNSPQSSPTSTPKLSKSLSFEMQQDELIEKPMSPMQYARSGLGTAEMNGKLIAAGGYN- 377
Query: 365 SGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG-----ECLYSME 419
+ C V CYNP T+ WS + PM+ RA+ ++ L G LY +GG + L E
Sbjct: 378 ---REECLRTVECYNPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGE 434
Query: 420 CYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFY--RLLR----YSPVKDAW 473
YD D W P L A G +Y+ GG Y + L+ + PV W
Sbjct: 435 MYDSNIDDWIPVPELRTNRCNAG--VCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKLW 492
Query: 474 DECPYSASHRRSSDIVALGGFLYRFDLLRGVGA-----AVMRYNTVTGSWSRAASL 524
C R S + LGG+LY ++ G + V RYN +W+ A +
Sbjct: 493 TSCAPLNIRRHQSAVCELGGYLY---IIGGAESWNCLNTVERYNPENNTWTLIAPM 545
Score = 73.2 bits (178), Expect = 6e-13
Identities = 56/207 (27%), Positives = 89/207 (42%), Gaps = 18/207 (8%)
Query: 324 VFNPRENTWRPLTQVPEEAPLR-GCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLT 382
+++ + W P VPE R G+C ++ L++ GG G K + + +VF +P+T
Sbjct: 435 MYDSNIDDWIP---VPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVF--DPVT 489
Query: 383 NIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAGT 438
+W+ P+ R Q + L G LY IGG CL ++E Y+P + WT AP+
Sbjct: 490 KLWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVAR 549
Query: 439 FPVAHEAVACRGDIYVTGG----HLFYRLLRYSPVKDAWDECPYSASHRRSSDIVALGGF 494
G ++V GG H + Y P ++ W S R ++ I +G
Sbjct: 550 RGAG--VAVLNGKLFVCGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGIATVGNT 607
Query: 495 LYRFDLLRG--VGAAVMRYNTVTGSWS 519
+Y G V YN + WS
Sbjct: 608 IYAVGGFDGNEFLNTVEVYNLESNEWS 634
Score = 58.2 bits (139), Expect = 2e-08
Identities = 33/110 (30%), Positives = 53/110 (48%), Gaps = 10/110 (9%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
+NP NTW + P RG G+ ++ LF+ GG GS A + V Y+P N
Sbjct: 532 YNPENNTWTLIA--PMNVARRGAGVAVLNGKLFVCGGFDGSHAISC----VEMYDPTRNE 585
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTP 430
W + M R+ + + +YA+GG E L ++E Y+ ++ W+P
Sbjct: 586 WKMMGNMTSPRSNAGIATVGNTIYAVGGFDGNEFLNTVEVYNLESNEWSP 635
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 78.6 bits (192), Expect = 2e-14
Identities = 58/215 (26%), Positives = 92/215 (42%), Gaps = 14/215 (6%)
Query: 320 AHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYN 379
++L +NP + TW L + + P G C + L+ GG S S+ + CYN
Sbjct: 340 SYLEAYNPSDGTWLRLADL--QVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
Query: 380 PLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGE--CLY--SMECYDPRTDAWTPRAPLP 435
P+TN WS PM R ++ + +DG +YA+GG C++ S+E Y+P D W AP+
Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
Query: 436 AGTFPVAHEAVACRGDIYVTGGHLFYRLLR----YSPVKDAWDECPYSASHRRSSDIVAL 491
V +Y GG L Y P ++ W + R + + L
Sbjct: 458 TRRIGVG--VAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVL 515
Query: 492 GGFLYRFDLLRGVGA--AVMRYNTVTGSWSRAASL 524
+Y G +V RY+ T +W+ A +
Sbjct: 516 HNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPM 550
Score = 69.3 bits (168), Expect = 9e-12
Identities = 39/117 (33%), Positives = 57/117 (48%), Gaps = 10/117 (8%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
+ P N WR +T + G G+C +HN ++ AGG G N V Y+ T
Sbjct: 490 YYPERNEWRMITAM--NTIRSGAGVCVLHNCIYAAGGYDGQDQL----NSVERYDVETET 543
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAG 437
W+ V PM+ R+ L + G +Y +GG L S+ECYDP TD W+ + +G
Sbjct: 544 WTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 78.6 bits (192), Expect = 2e-14
Identities = 58/215 (26%), Positives = 92/215 (42%), Gaps = 14/215 (6%)
Query: 320 AHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYN 379
++L +NP + TW L + + P G C + L+ GG S S+ + CYN
Sbjct: 340 SYLEAYNPSDGTWLRLADL--QVPRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYN 397
Query: 380 PLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGE--CLY--SMECYDPRTDAWTPRAPLP 435
P+TN WS PM R ++ + +DG +YA+GG C++ S+E Y+P D W AP+
Sbjct: 398 PMTNQWSPCAPMSVPRNRIGVGVIDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPML 457
Query: 436 AGTFPVAHEAVACRGDIYVTGGHLFYRLLR----YSPVKDAWDECPYSASHRRSSDIVAL 491
V +Y GG L Y P ++ W + R + + L
Sbjct: 458 TRRIGVG--VAVLNRLLYAVGGFDGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVL 515
Query: 492 GGFLYRFDLLRGVGA--AVMRYNTVTGSWSRAASL 524
+Y G +V RY+ T +W+ A +
Sbjct: 516 HNCIYAAGGYDGQDQLNSVERYDVETETWTFVAPM 550
Score = 69.3 bits (168), Expect = 9e-12
Identities = 39/117 (33%), Positives = 57/117 (48%), Gaps = 10/117 (8%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
+ P N WR +T + G G+C +HN ++ AGG G N V Y+ T
Sbjct: 490 YYPERNEWRMITAM--NTIRSGAGVCVLHNCIYAAGGYDGQDQL----NSVERYDVETET 543
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAG 437
W+ V PM+ R+ L + G +Y +GG L S+ECYDP TD W+ + +G
Sbjct: 544 WTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG 600
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 78.2 bits (191), Expect = 2e-14
Identities = 55/180 (30%), Positives = 88/180 (48%), Gaps = 17/180 (9%)
Query: 356 LFLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGE-- 413
++ GG+ +G N V ++P+ N W + RPM AR+++ + ++GLLYAIGG
Sbjct: 290 IYAVGGLNSAGDSL---NVVEVFDPIANCWERCRPMTTARSRVGVAVVNGLLYAIGGYDG 346
Query: 414 --CLYSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGH----LFYRLLRYS 467
L ++E Y+P TD WT + + A V G IYV GG+ + YS
Sbjct: 347 QLRLSTVEAYNPETDTWTRVGSM--NSKRSAMGTVVLDGQIYVCGGYDGNSSLSSVETYS 404
Query: 468 PVKDAWDECPYSASHRRSSDIVALGGFLY---RFDLLRGVGAAVMRYNTVTGSWSRAASL 524
P D W +S+R ++ + G +Y D L+ + ++V YN T +W AA +
Sbjct: 405 PETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGLQ-IFSSVEHYNHHTATWHPAAGM 463
Score = 62.0 bits (149), Expect = 1e-09
Identities = 37/114 (32%), Positives = 57/114 (50%), Gaps = 10/114 (8%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
+N TW P + + G ++ + +F+ GG GSG ++ Y+ + +
Sbjct: 450 YNHHTATWHPAAGMLNKRCRHGAA--SLGSKMFVCGGYDGSGFLSIAE----MYSSVADQ 503
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPL 434
W + PM R+++ LVA G LYA+GG L S+E YDP TD WT AP+
Sbjct: 504 WCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCWTFMAPM 557
>gi|31542246 kelch-like 36 [Homo sapiens]
Length = 616
Score = 78.2 bits (191), Expect = 2e-14
Identities = 61/201 (30%), Positives = 93/201 (46%), Gaps = 33/201 (16%)
Query: 349 LCTMHNYLFLAGGI--RGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGL 406
+ + ++F+AGG R +G A SN ++ Y+P W +V M Q R L +++ +
Sbjct: 340 VAVLGGFIFIAGGSFSRDNGGDAA-SNLLYRYDPRCKQWIKVASMNQRRVDFYLASIEDM 398
Query: 407 LYAIGGE----CLYSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLF-- 460
L AIGG L S+E Y P+TD+W+ A LP T+ H + +Y++GGH +
Sbjct: 399 LVAIGGRNENGALSSVETYSPKTDSWSYVAGLPRFTY--GHAGTIYKDFVYISGGHDYQI 456
Query: 461 --YR--LLRYSPVKDAWDECPYSASHRRSSDIVALGGFLY-------------RFDLLRG 503
YR LL Y D W+E + R + +LG +Y RFD+L
Sbjct: 457 GPYRKNLLCYDHRTDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVL-- 514
Query: 504 VGAAVMRYNTVTGSWSRAASL 524
V Y+ W+R A L
Sbjct: 515 ---GVEAYSPQCNQWTRVAPL 532
Score = 47.8 bits (112), Expect = 3e-05
Identities = 35/148 (23%), Positives = 65/148 (43%), Gaps = 18/148 (12%)
Query: 322 LHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPL 381
+ ++P+ ++W + +P G ++++++GG + CY+
Sbjct: 414 VETYSPKTDSWSYVAGLPRFT--YGHAGTIYKDFVYISGG--HDYQIGPYRKNLLCYDHR 469
Query: 382 TNIWSQVRPMQQARAQLKLVALDGLLYAIGGE----------CLYSMECYDPRTDAWTPR 431
T++W + RPM AR + +L +Y+IGG + +E Y P+ + WT
Sbjct: 470 TDVWEERRPMTTARGWHSMCSLGDSIYSIGGSDDNIESMERFDVLGVEAYSPQCNQWTRV 529
Query: 432 APLPAGTFPVAHEAVAC-RGDIYVTGGH 458
APL + VA G IY+ GG+
Sbjct: 530 APLLHAN---SESGVAVWEGRIYILGGY 554
Score = 38.5 bits (88), Expect = 0.018
Identities = 47/162 (29%), Positives = 66/162 (40%), Gaps = 35/162 (21%)
Query: 389 RPMQQARAQLKLVALDGLLYAIGGE----CLYSME--CY-DPRTDAWTPRAPLPAGTFPV 441
+P+ Q + + LL+ +GGE CL + CY D +++ W PLPA
Sbjct: 280 QPVMQTKRTALRTNQERLLF-VGGEVSERCLELSDDTCYLDAKSEQWVKETPLPARR--- 335
Query: 442 AHEAVACRGDIYVTGGHLFYR----------LLRYSPVKDAWDECPYSASHRR------- 484
+H VA G G F R L RY P W + S + RR
Sbjct: 336 SHHCVAVLGGFIFIAGGSFSRDNGGDAASNLLYRYDPRCKQWIKVA-SMNQRRVDFYLAS 394
Query: 485 -SSDIVALGGFLYRFDLLRGVGAAVMRYNTVTGSWSRAASLP 525
+VA+GG R + G ++V Y+ T SWS A LP
Sbjct: 395 IEDMLVAIGG---RNE--NGALSSVETYSPKTDSWSYVAGLP 431
>gi|88196794 kelch-like 35 [Homo sapiens]
Length = 363
Score = 77.8 bits (190), Expect = 3e-14
Identities = 53/212 (25%), Positives = 98/212 (46%), Gaps = 22/212 (10%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
++P W PL +P C + N ++++GG + S++V+ ++ +
Sbjct: 102 YHPESQRWTPLPSLPGYTRSEFAA-CALRNDVYVSGG-------HINSHDVWMFSSHLHT 153
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAGTFP 440
W +V + + R + K+ + G L+A+GG L+S+E YDP ++ W APLP
Sbjct: 154 WIKVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVERYDPFSNTWAAAAPLPEAVSS 213
Query: 441 VAHEAVACRGDIYVTGGHL-----FYRLLRYSPVKDAWDECPYSASHRRSSDIVALGGFL 495
A +C G ++V GG ++ + P +D W + +R + V+L +
Sbjct: 214 AA--VASCAGKLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTI 271
Query: 496 YRFDLLRGVGAAVMRYNTVTGSWSRAASLPLP 527
Y ++ G+ + + Y+ T W AA LP P
Sbjct: 272 Y---VMGGLMSKIFTYDPGTDVWGEAAVLPSP 300
Score = 65.1 bits (157), Expect = 2e-10
Identities = 54/189 (28%), Positives = 81/189 (42%), Gaps = 27/189 (14%)
Query: 270 RILSLRTGRGRAVLGVLVLPSLYQGGRSGLPRGPRGEEPPAAAPVSLPLPAHLHVFNPRE 329
++ SL GR R + V+ GG GL R E ++P
Sbjct: 156 KVASLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHSVER-----------------YDPFS 198
Query: 330 NTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVR 389
NTW +PE C LF+ GG R G V +++V C++P + WS
Sbjct: 199 NTWAAAAPLPEAVSSAAVASCA--GKLFVIGGARQGG---VNTDKVQCFDPKEDRWSLRS 253
Query: 390 PMQQARAQLKLVALDGLLYAIGGECLYSMECYDPRTDAWTPRAPLPAGTFPVAHEAV-AC 448
P ++ L+ V+L+ +Y +GG + + YDP TD W A LP+ PV V C
Sbjct: 254 PAPFSQRCLEAVSLEDTIYVMGG-LMSKIFTYDPGTDVWGEAAVLPS---PVESCGVTVC 309
Query: 449 RGDIYVTGG 457
G +++ GG
Sbjct: 310 DGKVHILGG 318
Score = 63.2 bits (152), Expect = 7e-10
Identities = 42/150 (28%), Positives = 65/150 (43%), Gaps = 12/150 (8%)
Query: 349 LCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLY 408
+ + LF GG G + V Y+P +N W+ P+ +A + + + G L+
Sbjct: 169 MAVVQGQLFAVGGFDGLRRL----HSVERYDPFSNTWAAAAPLPEAVSSAAVASCAGKLF 224
Query: 409 AIGGEC-----LYSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRL 463
IGG ++C+DP+ D W+ R+P P + EAV+ IYV GG L ++
Sbjct: 225 VIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCL--EAVSLEDTIYVMGG-LMSKI 281
Query: 464 LRYSPVKDAWDECPYSASHRRSSDIVALGG 493
Y P D W E S S + G
Sbjct: 282 FTYDPGTDVWGEAAVLPSPVESCGVTVCDG 311
Score = 48.1 bits (113), Expect = 2e-05
Identities = 52/209 (24%), Positives = 79/209 (37%), Gaps = 53/209 (25%)
Query: 419 ECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHL-FYRLLRYSPVKDAWDECP 477
+ Y P + WTP LP T A A R D+YV+GGH+ + + +S W +
Sbjct: 100 DAYHPESQRWTPLPSLPGYTRS-EFAACALRNDVYVSGGHINSHDVWMFSSHLHTWIKVA 158
Query: 478 YSASHRRSSDIVALGGFLYR---FDLLRGVGAAVMRYNTVTGSWSRAASLP--------- 525
R + + G L+ FD LR + + V RY+ + +W+ AA LP
Sbjct: 159 SLHKGRWRHKMAVVQGQLFAVGGFDGLRRLHS-VERYDPFSNTWAAAAPLPEAVSSAAVA 217
Query: 526 ---------------------------------LPAPAP-----LHCTTLGNTIYCLNPQ 547
L +PAP L +L +TIY +
Sbjct: 218 SCAGKLFVIGGARQGGVNTDKVQCFDPKEDRWSLRSPAPFSQRCLEAVSLEDTIYVMGGL 277
Query: 548 VTATFTVSGGTAQFQAKELQPFPLGSTGV 576
++ FT GT + + P P+ S GV
Sbjct: 278 MSKIFTYDPGTDVWGEAAVLPSPVESCGV 306
>gi|55925608 kelch-like 21 [Homo sapiens]
Length = 597
Score = 77.8 bits (190), Expect = 3e-14
Identities = 60/206 (29%), Positives = 88/206 (42%), Gaps = 20/206 (9%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
+NP+ WR L + P+ G + + N +++ GG GS V+ YN N
Sbjct: 307 YNPQTGQWRYLAEFPDHLG-GGYSIVALGNDIYVTGGSDGSRLYDC----VWRYNSSVNE 361
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGGECLYSMECYDPRTDAWTPRAPLPAGTFPVAH- 443
W++V PM +AR LDGLLY + + S E YD TD+W P+ T+P+ +
Sbjct: 362 WAEVAPMLKAREYHSSSVLDGLLYVVAAD---STERYDHTTDSWEALQPM---TYPMDNC 415
Query: 444 EAVACRGDIYVTG---GHLFYRLLRYSPVKDAWD--ECPYSASHRRSSDIVALGGFLYRF 498
ACRG +Y G G + Y P D W +C + L G +Y
Sbjct: 416 STTACRGRLYAIGSLAGKETMVMQCYDPDTDLWSLVDCGQLPPWSFAPKTATLNGLMY-- 473
Query: 499 DLLRGVGAAVMRYNTVTGSWSRAASL 524
+R A V YN W + S+
Sbjct: 474 -FVRDDSAEVDVYNPTRNEWDKIPSM 498
Score = 48.5 bits (114), Expect = 2e-05
Identities = 29/73 (39%), Positives = 33/73 (45%), Gaps = 5/73 (6%)
Query: 372 SNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG-----ECLYSMECYDPRTD 426
S EV YNP N W ++ M Q L L G LY GG E +E YDP T
Sbjct: 479 SAEVDVYNPTRNEWDKIPSMNQVHVGGSLAVLGGKLYVSGGYDNTFELSDVVEAYDPETR 538
Query: 427 AWTPRAPLPAGTF 439
AW+ LP TF
Sbjct: 539 AWSVVGRLPEPTF 551
Score = 46.2 bits (108), Expect = 8e-05
Identities = 86/332 (25%), Positives = 123/332 (37%), Gaps = 49/332 (14%)
Query: 205 ALEPATAAALRRRLDLGSCLDVLAFAQQHGEPGLAQETYALMSDNLLRVLGDPCLYRRLS 264
A++ A A L+++LDL +CLD+ FA+ GLA +LR +G+ L
Sbjct: 120 AVKEACGAFLQQQLDLANCLDMQDFAEAFSCSGLASAAQRF----ILRHVGE------LG 169
Query: 265 AADRERILSLRTGRGRAVLGVLVLPSLYQGGRSGLPRGPRGEEPPAAAPVSLPLPAHLHV 324
A ER+ R R G+ V P + L R R + P AA L A V
Sbjct: 170 AEQLERLPLARLLRYLRDDGLCV-PKEEAAYQLAL-RWVRADPPRRAAHWPQLLEA---V 224
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
P + L V E + C C L L R A ++
Sbjct: 225 RLPFVRRFYLLAHVEAEPLVARCPPC-----LRLLREARDFQAARYDRHD-------RGP 272
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG---EC--LYSMECYDPRTDAWTPRAPLPAGTF 439
++RP L +L +GG +C L +++CY+P+T W A P
Sbjct: 273 CPRMRPRPST-------GLAEILVLVGGCDQDCDELVTVDCYNPQTGQWRYLAEFP-DHL 324
Query: 440 PVAHEAVACRGDIYVTGG----HLFYRLLRYSPVKDAWDECPYSASHRRSSDIVALGGFL 495
+ VA DIYVTGG L+ + RY+ + W E R L G L
Sbjct: 325 GGGYSIVALGNDIYVTGGSDGSRLYDCVWRYNSSVNEWAEVAPMLKAREYHSSSVLDGLL 384
Query: 496 YRFDLLRGVGAAVMRYNTVTGSWSRAASLPLP 527
Y + RY+ T SW + P
Sbjct: 385 YVV-----AADSTERYDHTTDSWEALQPMTYP 411
>gi|158508542 kelch-like 33 [Homo sapiens]
Length = 453
Score = 76.6 bits (187), Expect = 6e-14
Identities = 58/166 (34%), Positives = 75/166 (45%), Gaps = 22/166 (13%)
Query: 378 YNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGE----CLYSMECYDPRTDAWTPRAP 433
+ P W ++ P+ QAR+ LVALDG LYA+GG L S+E Y+P + W P
Sbjct: 215 WEPSQEDWEEMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPA 274
Query: 434 LPAGTFPVAHEAVACRGDIYVTG-----GHLFYRLLRYSP--VKDAWDECPYSASHRRSS 486
LPA F AH A G +YV+G G L+ Y P K P R
Sbjct: 275 LPAPCF--AHAAAILEGQLYVSGGCGGTGQYLASLMHYDPKLEKPGTFLSPMGVP-RAGH 331
Query: 487 DIVALGGFLYRFDLLRGVG-----AAVMRYNTVTGSWSRAASLPLP 527
+ ALGG LY + G+G + Y T SW+ A LP P
Sbjct: 332 VMAALGGRLY---VAGGLGETEDLLSFEAYELRTDSWTHLAPLPSP 374
Score = 66.2 bits (160), Expect = 8e-11
Identities = 47/142 (33%), Positives = 68/142 (47%), Gaps = 12/142 (8%)
Query: 322 LHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNP- 380
+ +NP N WRP +P AP + L+++GG G+G + Y+P
Sbjct: 259 VETYNPELNVWRPAPALP--APCFAHAAAILEGQLYVSGGCGGTGQYLA---SLMHYDPK 313
Query: 381 LTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPA 436
L + + PM RA + AL G LY GG E L S E Y+ RTD+WT APLP+
Sbjct: 314 LEKPGTFLSPMGVPRAGHVMAALGGRLYVAGGLGETEDLLSFEAYELRTDSWTHLAPLPS 373
Query: 437 GTFPVAHEAVACRGDIYVTGGH 458
V + +G++ V GG+
Sbjct: 374 P--HVGAASAVLQGELLVLGGY 393
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/115 (33%), Positives = 49/115 (42%), Gaps = 13/115 (11%)
Query: 424 RTDAWTPRAPLPA-GTFPVAHEAVACRG-DIYVTGGHLFYR-------LLRYSPVKDAWD 474
RT W LPA G F H A + G ++YV GG FY LR+ P ++ W+
Sbjct: 166 RTVEWGQLPALPAPGRF--RHGAASLAGSELYVCGGQDFYSHSNTLASTLRWEPSQEDWE 223
Query: 475 ECPYSASHRRSSDIVALGGFLYRFDLLRGVGA--AVMRYNTVTGSWSRAASLPLP 527
E + R +VAL G LY A +V YN W A +LP P
Sbjct: 224 EMAPLSQARSLFSLVALDGKLYALGGRHNDVALDSVETYNPELNVWRPAPALPAP 278
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 75.9 bits (185), Expect = 1e-13
Identities = 96/355 (27%), Positives = 133/355 (37%), Gaps = 50/355 (14%)
Query: 206 LEPATAAALRRRLDLGSCLDVLAFAQQHGEPGLAQETYALMSDNLLRVLGDPCLYRRLSA 265
++ A L+R+LD +CL + AFA H L + N V+ + L A
Sbjct: 153 IQEACCEFLKRQLDPSNCLGIRAFADTHSCRELLRIADKFTQHNFQEVMESE-EFMLLPA 211
Query: 266 ADRERILS---LRTGRGRAVLGVLVLPSLY--QGGRSGLPRGPRGEEPPAAAPVSL---- 316
I+S L V ++ Y Q R LP+ + P +P L
Sbjct: 212 NQLIDIISSDELNVRSEEQVFNAVMAWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTV 271
Query: 317 ---PL------------PAHLHVFNPRENTWRPLTQVPEEAPLRG--CGLCTMHNYLFLA 359
PL A ++ P+E RPL Q P P + CG LF
Sbjct: 272 GSDPLIKSDEECRDLVDEAKNYLLLPQE---RPLMQGPRTRPRKPIRCG-----EVLFAV 323
Query: 360 GGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECL 415
GG A + V Y+P TN W V M + R + + LD LLYA+GG L
Sbjct: 324 GGWCSGDA----ISSVERYDPQTNEWRMVASMSKRRCGVGVSVLDDLLYAVGGHDGSSYL 379
Query: 416 YSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRLL----RYSPVKD 471
S+E YDP+T+ W+ P T + G +Y GG L RY P ++
Sbjct: 380 NSVERYDPKTNQWSSDV-APTSTCRTSVGVAVLGGFLYAVGGQDGVSCLNIVERYDPKEN 438
Query: 472 AWDECPYSASHRRSSDIVALGGFLYRFDLLRGVGA--AVMRYNTVTGSWSRAASL 524
W ++ R + LGGFLY G V RYN W A +
Sbjct: 439 KWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPM 493
Score = 59.3 bits (142), Expect = 1e-08
Identities = 52/189 (27%), Positives = 79/189 (41%), Gaps = 30/189 (15%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGC----GLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNP 380
++P+ N W + AP C G+ + +L+ GG G C N V Y+P
Sbjct: 385 YDPKTNQWSS-----DVAPTSTCRTSVGVAVLGGFLYAVGGQDGVS----CLNIVERYDP 435
Query: 381 LTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPA 436
N W++V M R + + L G LYA+GG L ++E Y+P+ + W AP+
Sbjct: 436 KENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVERYNPQENRWHTIAPM-- 493
Query: 437 GTFPVAHEAVACRGDIYVTGGHLFYRLL----RYSPVKDAWDECPYSASHRR-------S 485
GT + IY GG L RY+P + W S R +
Sbjct: 494 GTRRKHLGCAVYQDMIYAVGGRDDTTELSSAERYNPRTNQWSPVVAMTSRRSGVGLAVVN 553
Query: 486 SDIVALGGF 494
++A+GGF
Sbjct: 554 GQLMAVGGF 562
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 75.1 bits (183), Expect = 2e-13
Identities = 62/216 (28%), Positives = 92/216 (42%), Gaps = 29/216 (13%)
Query: 348 GLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLL 407
G+ + + LF+ GG G K + N V CYNP T W+ + PM R L + L+G +
Sbjct: 500 GVAVIDDKLFVIGG--RDGLKTL--NTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPI 555
Query: 408 YAIGG----ECLYSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGH----L 459
YA+GG L ++E +DP++ WT A + V A G +Y GG
Sbjct: 556 YAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVG--VAALNGKLYSVGGRDGSSC 613
Query: 460 FYRLLRYSPVKDAWDECPYSASHRRSSDIVALGGFLYRFDLLRGVGAA-----------V 508
+ Y P + W+ C R + GFLY + G A V
Sbjct: 614 LSSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLY---AVGGHDAPASNHCSRLLDYV 670
Query: 509 MRYNTVTGSWSRAASLPLPAPAPLHCTTLGNTIYCL 544
RY+ T +W+ A L +P A C LG+ +Y +
Sbjct: 671 ERYDPKTDTWTMVAPLSMPRDAVGVC-LLGDRLYAV 705
Score = 61.2 bits (147), Expect = 3e-09
Identities = 44/157 (28%), Positives = 66/157 (42%), Gaps = 12/157 (7%)
Query: 378 YNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAP 433
Y+ TN+W Q M R Q + +D L+ IGG + L ++ECY+P+T WT P
Sbjct: 479 YDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPP 538
Query: 434 LPAGTFPVAHEAVACRGDIYVTGGHLFYRLL----RYSPVKDAWDECPYSASHRRSSDIV 489
+ T G IY GGH + L R+ P W + R + +
Sbjct: 539 M--STHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIARSTVGVA 596
Query: 490 ALGGFLYRFDLLRGVG--AAVMRYNTVTGSWSRAASL 524
AL G LY G +++ Y+ T W+ A +
Sbjct: 597 ALNGKLYSVGGRDGSSCLSSMEYYDPHTNKWNMCAPM 633
Score = 57.8 bits (138), Expect = 3e-08
Identities = 38/123 (30%), Positives = 58/123 (47%), Gaps = 10/123 (8%)
Query: 322 LHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCS---NEVFCY 378
+ ++P N W + + G G+ T +L+ GG + A CS + V Y
Sbjct: 617 MEYYDPHTNKWNMCAPMCKRRG--GVGVATCDGFLYAVGG-HDAPASNHCSRLLDYVERY 673
Query: 379 NPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPL 434
+P T+ W+ V P+ R + + L LYA+GG L +ME YDP+T+ WT A L
Sbjct: 674 DPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASL 733
Query: 435 PAG 437
G
Sbjct: 734 NIG 736
Score = 38.1 bits (87), Expect = 0.023
Identities = 26/99 (26%), Positives = 46/99 (46%), Gaps = 7/99 (7%)
Query: 305 GEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRG 364
G + PA+ S L ++ ++P+ +TW + P P G+C + + L+ GG G
Sbjct: 654 GHDAPASNHCSRLLD-YVERYDPKTDTWTMVA--PLSMPRDAVGVCLLGDRLYAVGGYDG 710
Query: 365 SGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVAL 403
N + Y+P TN W+Q+ + RA +V +
Sbjct: 711 Q----TYLNTMESYDPQTNEWTQMASLNIGRAGACVVVI 745
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 74.7 bits (182), Expect = 2e-13
Identities = 50/167 (29%), Positives = 83/167 (49%), Gaps = 13/167 (7%)
Query: 316 LPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCS-NE 374
L + L +++ + + W+ L P +AP G+ + N+L++ GG K + +
Sbjct: 353 LVVSKELRMYDEKAHEWKSLA--PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDT 410
Query: 375 VFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGEC----LYSMECYDPRTDAWTP 430
VF ++P N W QV + + R L AL G LYA+GG L ++ECY+PRT+ WT
Sbjct: 411 VFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTY 470
Query: 431 RAPLPAGTFPVAHEAVACRGDIYVTGG--HLFYR--LLRYSPVKDAW 473
A + + H G +Y++GG H ++ L+ + P D W
Sbjct: 471 VAKMSEPHY--GHAGTVYGGVMYISGGITHDTFQKELMCFDPDTDKW 515
Score = 60.8 bits (146), Expect = 3e-09
Identities = 46/164 (28%), Positives = 67/164 (40%), Gaps = 23/164 (14%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
+NPR N W + ++ E P G ++++GGI E+ C++P T+
Sbjct: 461 YNPRTNEWTYVAKMSE--PHYGHAGTVYGGVMYISGGITHD----TFQKELMCFDPDTDK 514
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG---------ECLYSMECYDPRTDAWTPRAPLP 435
W Q PM R + + LY IGG + + S E Y P D WTP A +
Sbjct: 515 WIQKAPMTTVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAML 574
Query: 436 AGTFPVAHEAVACRGDIYVTGGHLFYR------LLRYSPVKDAW 473
G V IYV GG+ + + +Y P KD W
Sbjct: 575 RGQSDVG--VAVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 74.3 bits (181), Expect = 3e-13
Identities = 64/238 (26%), Positives = 99/238 (41%), Gaps = 29/238 (12%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
++ R N W P+ + G+ + + L++ GG G K + N V CYNP T
Sbjct: 441 YDLRTNMWTPVANM--NGRRLQFGVAVLDDKLYVVGG--RDGLKTL--NTVECYNPKTKT 494
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPL--PAGT 438
WS + PM R L + L+G +YA+GG L ++E +DP+ W A + P T
Sbjct: 495 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 554
Query: 439 FPVAHEAVACRGDIYVTGGHLFYRLLR----YSPVKDAWDECPYSASHRRSSDIVALGGF 494
VA G +Y GG L+ + P + W C + R + G
Sbjct: 555 VGVA----VLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 610
Query: 495 LYRF--------DLLRGVGAAVMRYNTVTGSWSRAASLPLPAPAPLHCTTLGNTIYCL 544
LY +L + V RY+ T W+ AS+ + A C LG+ +Y +
Sbjct: 611 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVC-LLGDKLYAV 667
Score = 58.5 bits (140), Expect = 2e-08
Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 8/119 (6%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGG--IRGSGAKAVCSNEVFCYNPLT 382
F+P N W Q+ + G G+ T + L+ GG S + S+ V Y+P T
Sbjct: 582 FDPHTNKWTLCAQMSKRRG--GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKT 639
Query: 383 NIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAG 437
++W+ V M +R + + L LYA+GG L ++E YDP+T+ WT APL G
Sbjct: 640 DMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 698
Score = 45.1 bits (105), Expect = 2e-04
Identities = 42/150 (28%), Positives = 62/150 (41%), Gaps = 14/150 (9%)
Query: 389 RPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAGTFPVAHE 444
RPM Q+ + G L+A+GG + S+E YD RT+ WTP A +
Sbjct: 405 RPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF--- 461
Query: 445 AVACRGD-IYVTGGHLFYRLLR----YSPVKDAWDECPYSASHRRSSDIVALGGFLYRFD 499
VA D +YV GG + L Y+P W P ++HR + L G +Y
Sbjct: 462 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVG 521
Query: 500 LLRGVG--AAVMRYNTVTGSWSRAASLPLP 527
G V R++ W+ A++ P
Sbjct: 522 GHDGWSYLNTVERWDPQARQWNFVATMSTP 551
Score = 35.4 bits (80), Expect = 0.15
Identities = 27/100 (27%), Positives = 44/100 (44%), Gaps = 7/100 (7%)
Query: 297 SGLPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYL 356
+GL G + PA+ S L + ++P+ + W + + G+C + + L
Sbjct: 608 NGLLYAIGGHDAPASNLTSR-LSDCVERYDPKTDMWTAVASMSISRD--AVGVCLLGDKL 664
Query: 357 FLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARA 396
+ GG G N V Y+P TN W+QV P+ RA
Sbjct: 665 YAVGGYDGQAYL----NTVEAYDPQTNEWTQVAPLCLGRA 700
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 74.3 bits (181), Expect = 3e-13
Identities = 64/238 (26%), Positives = 99/238 (41%), Gaps = 29/238 (12%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
++ R N W P+ + G+ + + L++ GG G K + N V CYNP T
Sbjct: 426 YDLRTNMWTPVANM--NGRRLQFGVAVLDDKLYVVGG--RDGLKTL--NTVECYNPKTKT 479
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPL--PAGT 438
WS + PM R L + L+G +YA+GG L ++E +DP+ W A + P T
Sbjct: 480 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 539
Query: 439 FPVAHEAVACRGDIYVTGGHLFYRLLR----YSPVKDAWDECPYSASHRRSSDIVALGGF 494
VA G +Y GG L+ + P + W C + R + G
Sbjct: 540 VGVA----VLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 595
Query: 495 LYRF--------DLLRGVGAAVMRYNTVTGSWSRAASLPLPAPAPLHCTTLGNTIYCL 544
LY +L + V RY+ T W+ AS+ + A C LG+ +Y +
Sbjct: 596 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVC-LLGDKLYAV 652
Score = 58.5 bits (140), Expect = 2e-08
Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 8/119 (6%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGG--IRGSGAKAVCSNEVFCYNPLT 382
F+P N W Q+ + G G+ T + L+ GG S + S+ V Y+P T
Sbjct: 567 FDPHTNKWTLCAQMSKRRG--GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKT 624
Query: 383 NIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAG 437
++W+ V M +R + + L LYA+GG L ++E YDP+T+ WT APL G
Sbjct: 625 DMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 683
Score = 45.1 bits (105), Expect = 2e-04
Identities = 42/150 (28%), Positives = 62/150 (41%), Gaps = 14/150 (9%)
Query: 389 RPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAGTFPVAHE 444
RPM Q+ + G L+A+GG + S+E YD RT+ WTP A +
Sbjct: 390 RPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF--- 446
Query: 445 AVACRGD-IYVTGGHLFYRLLR----YSPVKDAWDECPYSASHRRSSDIVALGGFLYRFD 499
VA D +YV GG + L Y+P W P ++HR + L G +Y
Sbjct: 447 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVG 506
Query: 500 LLRGVG--AAVMRYNTVTGSWSRAASLPLP 527
G V R++ W+ A++ P
Sbjct: 507 GHDGWSYLNTVERWDPQARQWNFVATMSTP 536
Score = 35.4 bits (80), Expect = 0.15
Identities = 27/100 (27%), Positives = 44/100 (44%), Gaps = 7/100 (7%)
Query: 297 SGLPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYL 356
+GL G + PA+ S L + ++P+ + W + + G+C + + L
Sbjct: 593 NGLLYAIGGHDAPASNLTSR-LSDCVERYDPKTDMWTAVASMSISRD--AVGVCLLGDKL 649
Query: 357 FLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARA 396
+ GG G N V Y+P TN W+QV P+ RA
Sbjct: 650 YAVGGYDGQAYL----NTVEAYDPQTNEWTQVAPLCLGRA 685
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 74.3 bits (181), Expect = 3e-13
Identities = 64/238 (26%), Positives = 99/238 (41%), Gaps = 29/238 (12%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
++ R N W P+ + G+ + + L++ GG G K + N V CYNP T
Sbjct: 487 YDLRTNMWTPVANM--NGRRLQFGVAVLDDKLYVVGG--RDGLKTL--NTVECYNPKTKT 540
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPL--PAGT 438
WS + PM R L + L+G +YA+GG L ++E +DP+ W A + P T
Sbjct: 541 WSVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRST 600
Query: 439 FPVAHEAVACRGDIYVTGGHLFYRLLR----YSPVKDAWDECPYSASHRRSSDIVALGGF 494
VA G +Y GG L+ + P + W C + R + G
Sbjct: 601 VGVA----VLSGKLYAVGGRDGSSCLKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGL 656
Query: 495 LYRF--------DLLRGVGAAVMRYNTVTGSWSRAASLPLPAPAPLHCTTLGNTIYCL 544
LY +L + V RY+ T W+ AS+ + A C LG+ +Y +
Sbjct: 657 LYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVC-LLGDKLYAV 713
Score = 58.5 bits (140), Expect = 2e-08
Identities = 39/119 (32%), Positives = 59/119 (49%), Gaps = 8/119 (6%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGG--IRGSGAKAVCSNEVFCYNPLT 382
F+P N W Q+ + G G+ T + L+ GG S + S+ V Y+P T
Sbjct: 628 FDPHTNKWTLCAQMSKRRG--GVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKT 685
Query: 383 NIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAG 437
++W+ V M +R + + L LYA+GG L ++E YDP+T+ WT APL G
Sbjct: 686 DMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPLCLG 744
Score = 45.1 bits (105), Expect = 2e-04
Identities = 42/150 (28%), Positives = 62/150 (41%), Gaps = 14/150 (9%)
Query: 389 RPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAGTFPVAHE 444
RPM Q+ + G L+A+GG + S+E YD RT+ WTP A +
Sbjct: 451 RPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF--- 507
Query: 445 AVACRGD-IYVTGGHLFYRLLR----YSPVKDAWDECPYSASHRRSSDIVALGGFLYRFD 499
VA D +YV GG + L Y+P W P ++HR + L G +Y
Sbjct: 508 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTWSVMPPMSTHRHGLGVAVLEGPMYAVG 567
Query: 500 LLRGVG--AAVMRYNTVTGSWSRAASLPLP 527
G V R++ W+ A++ P
Sbjct: 568 GHDGWSYLNTVERWDPQARQWNFVATMSTP 597
Score = 35.4 bits (80), Expect = 0.15
Identities = 27/100 (27%), Positives = 44/100 (44%), Gaps = 7/100 (7%)
Query: 297 SGLPRGPRGEEPPAAAPVSLPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYL 356
+GL G + PA+ S L + ++P+ + W + + G+C + + L
Sbjct: 654 NGLLYAIGGHDAPASNLTSR-LSDCVERYDPKTDMWTAVASMSISRD--AVGVCLLGDKL 710
Query: 357 FLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARA 396
+ GG G N V Y+P TN W+QV P+ RA
Sbjct: 711 YAVGGYDGQAYL----NTVEAYDPQTNEWTQVAPLCLGRA 746
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 73.2 bits (178), Expect = 6e-13
Identities = 69/247 (27%), Positives = 102/247 (41%), Gaps = 26/247 (10%)
Query: 348 GLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLL 407
G+ + N L++ GG G K + N V C+NP+ IW+ + PM R L + L+G +
Sbjct: 470 GVAVIDNKLYVVGG--RDGLKTL--NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPM 525
Query: 408 YAIGG----ECLYSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRL 463
YA+GG L ++E +DP W A + V VA +Y GG
Sbjct: 526 YAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVG--VVALNNKLYAIGGRDGSSC 583
Query: 464 LR----YSPVKDAWDECPYSASHRRSSDIVALGGFLY--------RFDLLRGVGAAVMRY 511
L+ + P + W C + R + GFLY + + V RY
Sbjct: 584 LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERY 643
Query: 512 NTVTGSWSRAASLPLPAPAPLHCTTLGNTIYCLNPQVTATF--TVSGGTAQ-FQAKELQP 568
+ SWS A L +P A C LG+ +Y + T+ TV AQ + KE P
Sbjct: 644 DPKGDSWSTVAPLSVPRDAVAVC-PLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVP 702
Query: 569 FPLGSTG 575
+G G
Sbjct: 703 VNIGRAG 709
Score = 55.1 bits (131), Expect = 2e-07
Identities = 49/208 (23%), Positives = 80/208 (38%), Gaps = 32/208 (15%)
Query: 378 YNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAP 433
Y+ TN W + M R Q + +D LY +GG + L ++EC++P WT P
Sbjct: 449 YDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPP 508
Query: 434 LPAGTFPVAHEAVACRGDIYVTGGHLFYRLL----RYSPVKDAWDECPYSASHRRSSDIV 489
+ T G +Y GGH + L R+ P W+ ++ R + +V
Sbjct: 509 M--STHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVV 566
Query: 490 ALGGFLYRFDLLRGVGA--AVMRYNTVTGSWSRAASLPL--------------------P 527
AL LY G ++ ++ T WS A +
Sbjct: 567 ALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHD 626
Query: 528 APAPLHCTTLGNTIYCLNPQVTATFTVS 555
APA HC+ L + + +P+ + TV+
Sbjct: 627 APASNHCSRLSDCVERYDPKGDSWSTVA 654
>gi|24308181 kelch-like 9 [Homo sapiens]
Length = 617
Score = 72.8 bits (177), Expect = 8e-13
Identities = 50/167 (29%), Positives = 81/167 (48%), Gaps = 13/167 (7%)
Query: 316 LPLPAHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCS-NE 374
L + L +++ R WR L P +AP G+ + N+L++ GG K + +
Sbjct: 311 LVVSKELRMYDERAQEWRSLA--PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDT 368
Query: 375 VFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGGEC----LYSMECYDPRTDAWTP 430
VF ++P N W QV + + R L AL G LYA+GG L ++ECY+PR + W+
Sbjct: 369 VFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSY 428
Query: 431 RAPLPAGTFPVAHEAVACRGDIYVTGG--HLFYR--LLRYSPVKDAW 473
A + + H G +Y++GG H ++ L+ + P D W
Sbjct: 429 VAKMSEPHY--GHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKW 473
Score = 65.5 bits (158), Expect = 1e-10
Identities = 48/169 (28%), Positives = 70/169 (41%), Gaps = 23/169 (13%)
Query: 320 AHLHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYN 379
A + +NPR N W + ++ E P G ++++GGI NE+ C++
Sbjct: 414 ATVECYNPRMNEWSYVAKMSE--PHYGHAGTVYGGLMYISGGITHD----TFQNELMCFD 467
Query: 380 PLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG---------ECLYSMECYDPRTDAWTP 430
P T+ W Q PM R + + LY IGG + + S E Y P D WTP
Sbjct: 468 PDTDKWMQKAPMTTVRGLHCMCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTLDQWTP 527
Query: 431 RAPLPAGTFPVAHEAVACRGDIYVTGGHLFYR------LLRYSPVKDAW 473
A + G V IYV GG+ + + +Y P KD W
Sbjct: 528 IAAMLRGQSDVG--VAVFENKIYVVGGYSWNNRCMVEIVQKYDPEKDEW 574
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 71.2 bits (173), Expect = 2e-12
Identities = 57/211 (27%), Positives = 93/211 (44%), Gaps = 20/211 (9%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
++P ++ W + + + G + ++ L+ GG GS + V YN +N
Sbjct: 285 YDPVKDQWTSVANMRDRRSTLGAAV--LNGLLYAVGGFDGSTGLS----SVEAYNIKSNE 338
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG------ECLYSMECYDPRTDAWTPRAPLPAGT 438
W V PM R+ + + + GLLYA+GG +CL ++ECY+ T+ WT A + T
Sbjct: 339 WFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM--ST 396
Query: 439 FPVAHEAVACRGDIYVTGGH---LFYRLLR-YSPVKDAWDECPYSASHRRSSDIVALGGF 494
+Y GGH L + + Y P +AW + RR++ + A+ G
Sbjct: 397 RRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGL 456
Query: 495 LYRFDLLRGVG--AAVMRYNTVTGSWSRAAS 523
LY G A+V YN T W+ +S
Sbjct: 457 LYVVGGDDGSCNLASVEYYNPTTDKWTVVSS 487
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/211 (25%), Positives = 89/211 (42%), Gaps = 24/211 (11%)
Query: 328 RENTWRPLTQVPEEAPLRGC--GLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIW 385
+E W + ++P R C G+ M +F GG GS + V Y+P+ + W
Sbjct: 241 KEERWHQVAELPS----RRCRAGMVYMAGLVFAVGGFNGS----LRVRTVDSYDPVKDQW 292
Query: 386 SQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAGTFPV 441
+ V M+ R+ L L+GLLYA+GG L S+E Y+ +++ W AP+ V
Sbjct: 293 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 352
Query: 442 AHEAVACRGDIYVTGGH------LFYRLLRYSPVKDAWDECPYSASHRRSSDIVALGGFL 495
V G +Y GG+ + Y+ + W ++ R + + L L
Sbjct: 353 GVGVVG--GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLL 410
Query: 496 YRFDLLRG--VGAAVMRYNTVTGSWSRAASL 524
Y G V +V Y+ T +W + A +
Sbjct: 411 YAVGGHDGPLVRKSVEVYDPTTNAWRQVADM 441
Score = 60.8 bits (146), Expect = 3e-09
Identities = 46/160 (28%), Positives = 66/160 (41%), Gaps = 14/160 (8%)
Query: 322 LHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPL 381
+ +N + N W + P G+ + L+ GG GA C + V CYN
Sbjct: 329 VEAYNIKSNEWFHVA--PMNTRRSSVGVGVVGGLLYAVGGY--DGASRQCLSTVECYNAT 384
Query: 382 TNIWSQVRPMQQARAQLKLVALDGLLYAIGGE----CLYSMECYDPRTDAWTPRAPLPAG 437
TN W+ + M R+ + L+ LLYA+GG S+E YDP T+AW A +
Sbjct: 385 TNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMC 444
Query: 438 TFPVAHEAVACRGDIYVTGGH----LFYRLLRYSPVKDAW 473
A G +YV GG + Y+P D W
Sbjct: 445 RRNAG--VCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 482
Score = 48.9 bits (115), Expect = 1e-05
Identities = 44/175 (25%), Positives = 70/175 (40%), Gaps = 16/175 (9%)
Query: 362 IRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYS 417
+ G KA+ S E CY+ W QV + R + +V + GL++A+GG + +
Sbjct: 224 VGGQAPKAIRSVE--CYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRT 281
Query: 418 MECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGH----LFYRLLRYSPVKDAW 473
++ YDP D WT A + + A G +Y GG + Y+ + W
Sbjct: 282 VDSYDPVKDQWTSVANMRDRRSTLG--AAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEW 339
Query: 474 DECPYSASHRRSSDIVALGGFLYRFDLLRGVG----AAVMRYNTVTGSWSRAASL 524
+ R S + +GG LY G + V YN T W+ A +
Sbjct: 340 FHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 394
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 71.2 bits (173), Expect = 2e-12
Identities = 57/211 (27%), Positives = 93/211 (44%), Gaps = 20/211 (9%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
++P ++ W + + + G + ++ L+ GG GS + V YN +N
Sbjct: 377 YDPVKDQWTSVANMRDRRSTLGAAV--LNGLLYAVGGFDGSTGLS----SVEAYNIKSNE 430
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG------ECLYSMECYDPRTDAWTPRAPLPAGT 438
W V PM R+ + + + GLLYA+GG +CL ++ECY+ T+ WT A + T
Sbjct: 431 WFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM--ST 488
Query: 439 FPVAHEAVACRGDIYVTGGH---LFYRLLR-YSPVKDAWDECPYSASHRRSSDIVALGGF 494
+Y GGH L + + Y P +AW + RR++ + A+ G
Sbjct: 489 RRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGL 548
Query: 495 LYRFDLLRGVG--AAVMRYNTVTGSWSRAAS 523
LY G A+V YN T W+ +S
Sbjct: 549 LYVVGGDDGSCNLASVEYYNPTTDKWTVVSS 579
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/211 (25%), Positives = 89/211 (42%), Gaps = 24/211 (11%)
Query: 328 RENTWRPLTQVPEEAPLRGC--GLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIW 385
+E W + ++P R C G+ M +F GG GS + V Y+P+ + W
Sbjct: 333 KEERWHQVAELPS----RRCRAGMVYMAGLVFAVGGFNGS----LRVRTVDSYDPVKDQW 384
Query: 386 SQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAGTFPV 441
+ V M+ R+ L L+GLLYA+GG L S+E Y+ +++ W AP+ V
Sbjct: 385 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 444
Query: 442 AHEAVACRGDIYVTGGH------LFYRLLRYSPVKDAWDECPYSASHRRSSDIVALGGFL 495
V G +Y GG+ + Y+ + W ++ R + + L L
Sbjct: 445 GVGVVG--GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLL 502
Query: 496 YRFDLLRG--VGAAVMRYNTVTGSWSRAASL 524
Y G V +V Y+ T +W + A +
Sbjct: 503 YAVGGHDGPLVRKSVEVYDPTTNAWRQVADM 533
Score = 60.8 bits (146), Expect = 3e-09
Identities = 46/160 (28%), Positives = 66/160 (41%), Gaps = 14/160 (8%)
Query: 322 LHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPL 381
+ +N + N W + P G+ + L+ GG GA C + V CYN
Sbjct: 421 VEAYNIKSNEWFHVA--PMNTRRSSVGVGVVGGLLYAVGGY--DGASRQCLSTVECYNAT 476
Query: 382 TNIWSQVRPMQQARAQLKLVALDGLLYAIGGE----CLYSMECYDPRTDAWTPRAPLPAG 437
TN W+ + M R+ + L+ LLYA+GG S+E YDP T+AW A +
Sbjct: 477 TNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMC 536
Query: 438 TFPVAHEAVACRGDIYVTGGH----LFYRLLRYSPVKDAW 473
A G +YV GG + Y+P D W
Sbjct: 537 RRNAG--VCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 574
Score = 48.9 bits (115), Expect = 1e-05
Identities = 44/175 (25%), Positives = 70/175 (40%), Gaps = 16/175 (9%)
Query: 362 IRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYS 417
+ G KA+ S E CY+ W QV + R + +V + GL++A+GG + +
Sbjct: 316 VGGQAPKAIRSVE--CYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRT 373
Query: 418 MECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGH----LFYRLLRYSPVKDAW 473
++ YDP D WT A + + A G +Y GG + Y+ + W
Sbjct: 374 VDSYDPVKDQWTSVANMRDRRSTLG--AAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEW 431
Query: 474 DECPYSASHRRSSDIVALGGFLYRFDLLRGVG----AAVMRYNTVTGSWSRAASL 524
+ R S + +GG LY G + V YN T W+ A +
Sbjct: 432 FHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 486
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 71.2 bits (173), Expect = 2e-12
Identities = 57/211 (27%), Positives = 93/211 (44%), Gaps = 20/211 (9%)
Query: 325 FNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNI 384
++P ++ W + + + G + ++ L+ GG GS + V YN +N
Sbjct: 373 YDPVKDQWTSVANMRDRRSTLGAAV--LNGLLYAVGGFDGSTGLS----SVEAYNIKSNE 426
Query: 385 WSQVRPMQQARAQLKLVALDGLLYAIGG------ECLYSMECYDPRTDAWTPRAPLPAGT 438
W V PM R+ + + + GLLYA+GG +CL ++ECY+ T+ WT A + T
Sbjct: 427 WFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM--ST 484
Query: 439 FPVAHEAVACRGDIYVTGGH---LFYRLLR-YSPVKDAWDECPYSASHRRSSDIVALGGF 494
+Y GGH L + + Y P +AW + RR++ + A+ G
Sbjct: 485 RRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGL 544
Query: 495 LYRFDLLRGVG--AAVMRYNTVTGSWSRAAS 523
LY G A+V YN T W+ +S
Sbjct: 545 LYVVGGDDGSCNLASVEYYNPTTDKWTVVSS 575
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/211 (25%), Positives = 89/211 (42%), Gaps = 24/211 (11%)
Query: 328 RENTWRPLTQVPEEAPLRGC--GLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIW 385
+E W + ++P R C G+ M +F GG GS + V Y+P+ + W
Sbjct: 329 KEERWHQVAELPS----RRCRAGMVYMAGLVFAVGGFNGS----LRVRTVDSYDPVKDQW 380
Query: 386 SQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAPLPAGTFPV 441
+ V M+ R+ L L+GLLYA+GG L S+E Y+ +++ W AP+ V
Sbjct: 381 TSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSV 440
Query: 442 AHEAVACRGDIYVTGGH------LFYRLLRYSPVKDAWDECPYSASHRRSSDIVALGGFL 495
V G +Y GG+ + Y+ + W ++ R + + L L
Sbjct: 441 GVGVVG--GLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLL 498
Query: 496 YRFDLLRG--VGAAVMRYNTVTGSWSRAASL 524
Y G V +V Y+ T +W + A +
Sbjct: 499 YAVGGHDGPLVRKSVEVYDPTTNAWRQVADM 529
Score = 60.8 bits (146), Expect = 3e-09
Identities = 46/160 (28%), Positives = 66/160 (41%), Gaps = 14/160 (8%)
Query: 322 LHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPL 381
+ +N + N W + P G+ + L+ GG GA C + V CYN
Sbjct: 417 VEAYNIKSNEWFHVA--PMNTRRSSVGVGVVGGLLYAVGGY--DGASRQCLSTVECYNAT 472
Query: 382 TNIWSQVRPMQQARAQLKLVALDGLLYAIGGE----CLYSMECYDPRTDAWTPRAPLPAG 437
TN W+ + M R+ + L+ LLYA+GG S+E YDP T+AW A +
Sbjct: 473 TNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMC 532
Query: 438 TFPVAHEAVACRGDIYVTGGH----LFYRLLRYSPVKDAW 473
A G +YV GG + Y+P D W
Sbjct: 533 RRNAG--VCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKW 570
Score = 48.9 bits (115), Expect = 1e-05
Identities = 44/175 (25%), Positives = 70/175 (40%), Gaps = 16/175 (9%)
Query: 362 IRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYS 417
+ G KA+ S E CY+ W QV + R + +V + GL++A+GG + +
Sbjct: 312 VGGQAPKAIRSVE--CYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRT 369
Query: 418 MECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGH----LFYRLLRYSPVKDAW 473
++ YDP D WT A + + A G +Y GG + Y+ + W
Sbjct: 370 VDSYDPVKDQWTSVANMRDRRSTLG--AAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEW 427
Query: 474 DECPYSASHRRSSDIVALGGFLYRFDLLRGVG----AAVMRYNTVTGSWSRAASL 524
+ R S + +GG LY G + V YN T W+ A +
Sbjct: 428 FHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEM 482
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 71.2 bits (173), Expect = 2e-12
Identities = 59/211 (27%), Positives = 88/211 (41%), Gaps = 23/211 (10%)
Query: 348 GLCTMHNYLFLAGGIRGSGAKAVCSNEVFCYNPLTNIWSQVRPMQQARAQLKLVALDGLL 407
G+ + N L++ GG G K + N V C+NP+ IW+ + PM R L + L+G +
Sbjct: 470 GVAVIDNKLYVVGG--RDGLKTL--NTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPM 525
Query: 408 YAIGG----ECLYSMECYDPRTDAWTPRAPLPAGTFPVAHEAVACRGDIYVTGGHLFYRL 463
YA+GG L ++E +DP W A + V VA +Y GG
Sbjct: 526 YAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVG--VVALNNKLYAIGGRDGSSC 583
Query: 464 LR----YSPVKDAWDECPYSASHRRSSDIVALGGFLY--------RFDLLRGVGAAVMRY 511
L+ + P + W C + R + GFLY + + V RY
Sbjct: 584 LKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERY 643
Query: 512 NTVTGSWSRAASLPLPAPAPLHCTTLGNTIY 542
+ SWS A L +P A C LG+ +Y
Sbjct: 644 DPKGDSWSTVAPLSVPRDAVAVC-PLGDKLY 673
Score = 55.1 bits (131), Expect = 2e-07
Identities = 49/208 (23%), Positives = 80/208 (38%), Gaps = 32/208 (15%)
Query: 378 YNPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAWTPRAP 433
Y+ TN W + M R Q + +D LY +GG + L ++EC++P WT P
Sbjct: 449 YDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPP 508
Query: 434 LPAGTFPVAHEAVACRGDIYVTGGHLFYRLL----RYSPVKDAWDECPYSASHRRSSDIV 489
+ T G +Y GGH + L R+ P W+ ++ R + +V
Sbjct: 509 M--STHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVV 566
Query: 490 ALGGFLYRFDLLRGVGA--AVMRYNTVTGSWSRAASLPL--------------------P 527
AL LY G ++ ++ T WS A +
Sbjct: 567 ALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHD 626
Query: 528 APAPLHCTTLGNTIYCLNPQVTATFTVS 555
APA HC+ L + + +P+ + TV+
Sbjct: 627 APASNHCSRLSDCVERYDPKGDSWSTVA 654
Score = 46.2 bits (108), Expect = 8e-05
Identities = 32/114 (28%), Positives = 50/114 (43%), Gaps = 10/114 (8%)
Query: 322 LHVFNPRENTWRPLTQVPEEAPLRGCGLCTMHNYLFLAGGIRGSGAKAVCSNEVFC---Y 378
+ F+P N W P G G+ T + +L++ GG + A CS C Y
Sbjct: 587 MEYFDPHTNKWSLCA--PMSKRRGGVGVATYNGFLYVVGG-HDAPASNHCSRLSDCVERY 643
Query: 379 NPLTNIWSQVRPMQQARAQLKLVALDGLLYAIGG----ECLYSMECYDPRTDAW 428
+P + WS V P+ R + + L LY +GG L ++E YD + + W
Sbjct: 644 DPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,296,815
Number of Sequences: 37866
Number of extensions: 1976603
Number of successful extensions: 19990
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 242
Number of HSP's successfully gapped in prelim test: 1472
Number of HSP's that attempted gapping in prelim test: 12282
Number of HSP's gapped (non-prelim): 6442
length of query: 594
length of database: 18,247,518
effective HSP length: 108
effective length of query: 486
effective length of database: 14,157,990
effective search space: 6880783140
effective search space used: 6880783140
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.