Search of human proteins with 20127551

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|20127551 transient receptor potential cation channel,
subfamily V, member 2 [Homo sapiens]
         (764 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|20127551 transient receptor potential cation channel, subfami...  1546   0.0  
gi|74315354 transient receptor potential cation channel, subfami...   631   0.0  
gi|74315352 transient receptor potential cation channel, subfami...   631   0.0  
gi|74315350 transient receptor potential cation channel, subfami...   631   0.0  
gi|74315348 transient receptor potential cation channel, subfami...   631   0.0  
gi|22547184 transient receptor potential cation channel, subfami...   554   e-157
gi|22547180 transient receptor potential cation channel, subfami...   443   e-124
gi|21735483 transient receptor potential cation channel, subfami...   433   e-121
gi|21314682 transient receptor potential cation channel, subfami...   225   1e-58
gi|17505200 transient receptor potential cation channel, subfami...   204   3e-52
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                         54   5e-07
gi|6912736 transient receptor potential cation channel, subfamil...    51   4e-06
gi|209863032 transient receptor potential cation channel, subfam...    50   1e-05
gi|209863030 transient receptor potential cation channel, subfam...    50   1e-05
gi|209863026 transient receptor potential cation channel, subfam...    50   1e-05
gi|209863024 transient receptor potential cation channel, subfam...    50   1e-05
gi|7706747 transient receptor potential cation channel, subfamil...    50   1e-05
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                        49   1e-05
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                         49   1e-05
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                         49   1e-05
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]     49   2e-05
gi|209863028 transient receptor potential cation channel, subfam...    47   7e-05
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                        47   9e-05
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                         47   9e-05
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                         47   9e-05
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                         47   9e-05
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                         47   9e-05
gi|20270347 ankyrin repeat domain 54 [Homo sapiens]                    44   4e-04
gi|116534990 ankyrin-like protein 1 [Homo sapiens]                     42   0.002
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                    42   0.002

>gi|20127551 transient receptor potential cation channel, subfamily
           V, member 2 [Homo sapiens]
          Length = 764

 Score = 1546 bits (4004), Expect = 0.0
 Identities = 764/764 (100%), Positives = 764/764 (100%)

Query: 1   MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNY 60
           MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNY
Sbjct: 1   MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNY 60

Query: 61  RKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCL 120
           RKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCL
Sbjct: 61  RKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCL 120

Query: 121 MKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVK 180
           MKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVK
Sbjct: 121 MKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVK 180

Query: 181 LLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQA 240
           LLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQA
Sbjct: 181 LLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQA 240

Query: 241 TDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKL 300
           TDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKL
Sbjct: 241 TDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKL 300

Query: 301 AAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAF 360
           AAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAF
Sbjct: 301 AAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAF 360

Query: 361 HCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAA 420
           HCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAA
Sbjct: 361 HCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAA 420

Query: 421 PHLKAEVGNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALL 480
           PHLKAEVGNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALL
Sbjct: 421 PHLKAEVGNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALL 480

Query: 481 TVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLL 540
           TVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLL
Sbjct: 481 TVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLL 540

Query: 541 IYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLEL 600
           IYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLEL
Sbjct: 541 IYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLEL 600

Query: 601 FKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIW 660
           FKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIW
Sbjct: 601 FKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIW 660

Query: 661 KLQKAISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPT 720
           KLQKAISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPT
Sbjct: 661 KLQKAISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPT 720

Query: 721 LCEDPSGAGVPRTLENPVLASPPKEDEDGASEENYVPVQLLQSN 764
           LCEDPSGAGVPRTLENPVLASPPKEDEDGASEENYVPVQLLQSN
Sbjct: 721 LCEDPSGAGVPRTLENPVLASPPKEDEDGASEENYVPVQLLQSN 764


>gi|74315354 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score =  631 bits (1627), Expect = 0.0
 Identities = 343/697 (49%), Positives = 464/697 (66%), Gaps = 19/697 (2%)

Query: 74  FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 133
           +DR  +F AV++   +DL  L  +L K+ K+LTD+E+ +  TGKTCL+KA+LNL DG N 
Sbjct: 113 YDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNT 172

Query: 134 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 193
            I  LL+I R + + + LVNA  TD YY+G +ALHIAIE+R++  V LLVENGA+V A A
Sbjct: 173 TIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 232

Query: 194 CGRFFQKGQGTC-FYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 252
            G FF+K +G   FYFGELPLSLAACT Q  +V +LL+N  Q A + A DS GNTVLHAL
Sbjct: 233 HGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHAL 292

Query: 253 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 312
           V ++DN+A+N   VTSMY+ +L  GA+L PT++LE++ N + +TPL LAA  GKI +  +
Sbjct: 293 VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAY 352

Query: 313 ILQREFSG--LSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHC-KSPHRHR 369
           ILQRE       HLSRKFTEW YGPV  SLYDL+ +D+CE+NSVLE+IA+   ++P+RH 
Sbjct: 353 ILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHD 412

Query: 370 MVVLEPLNKLLQAKWDLLIPK-FFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAE-V 427
           M+++EPLN+LLQ KWD  + + F+ NFL   +YM IFT  AY++P       P  K E  
Sbjct: 413 MLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV---DGLPPFKMEKT 469

Query: 428 GNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVL 487
           G+   +TG IL +LGG+Y     + YF +R   +   F+DSY E+LF  Q+L  + + VL
Sbjct: 470 GDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529

Query: 488 CFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLF 547
            F  ++ Y+  +V +L LGW N+LYYTRGFQ  GIY+VMI+K+ILRDL RF+ +Y+VFLF
Sbjct: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589

Query: 548 GFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGM 607
           GF+ A+V+L ++      P+   +     P     D    + Y  +    LELFKFTIGM
Sbjct: 590 GFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPD----SSYNSLYSTCLELFKFTIGM 645

Query: 608 GELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAIS 667
           G+L F E   F+ + ++LLLAYV+LTYILLLNMLIALM ETVN +A +S +IWKLQ+AI+
Sbjct: 646 GDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAIT 705

Query: 668 VLEMENGYWWC-RKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPS 726
           +L+ E  +  C RK  R+G +L VG  PDG  D RWCFRV+EVNW +W   +  + EDP 
Sbjct: 706 ILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPG 765

Query: 727 GA-GVPRTLENPVLASPPKEDEDGASEENYVPVQLLQ 762
              GV RTL   + +S       G   +N+  V LL+
Sbjct: 766 NCEGVKRTLSFSLRSS----RVSGRHWKNFALVPLLR 798


>gi|74315352 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score =  631 bits (1627), Expect = 0.0
 Identities = 343/697 (49%), Positives = 464/697 (66%), Gaps = 19/697 (2%)

Query: 74  FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 133
           +DR  +F AV++   +DL  L  +L K+ K+LTD+E+ +  TGKTCL+KA+LNL DG N 
Sbjct: 113 YDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNT 172

Query: 134 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 193
            I  LL+I R + + + LVNA  TD YY+G +ALHIAIE+R++  V LLVENGA+V A A
Sbjct: 173 TIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 232

Query: 194 CGRFFQKGQGTC-FYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 252
            G FF+K +G   FYFGELPLSLAACT Q  +V +LL+N  Q A + A DS GNTVLHAL
Sbjct: 233 HGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHAL 292

Query: 253 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 312
           V ++DN+A+N   VTSMY+ +L  GA+L PT++LE++ N + +TPL LAA  GKI +  +
Sbjct: 293 VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAY 352

Query: 313 ILQREFSG--LSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHC-KSPHRHR 369
           ILQRE       HLSRKFTEW YGPV  SLYDL+ +D+CE+NSVLE+IA+   ++P+RH 
Sbjct: 353 ILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHD 412

Query: 370 MVVLEPLNKLLQAKWDLLIPK-FFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAE-V 427
           M+++EPLN+LLQ KWD  + + F+ NFL   +YM IFT  AY++P       P  K E  
Sbjct: 413 MLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV---DGLPPFKMEKT 469

Query: 428 GNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVL 487
           G+   +TG IL +LGG+Y     + YF +R   +   F+DSY E+LF  Q+L  + + VL
Sbjct: 470 GDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529

Query: 488 CFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLF 547
            F  ++ Y+  +V +L LGW N+LYYTRGFQ  GIY+VMI+K+ILRDL RF+ +Y+VFLF
Sbjct: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589

Query: 548 GFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGM 607
           GF+ A+V+L ++      P+   +     P     D    + Y  +    LELFKFTIGM
Sbjct: 590 GFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPD----SSYNSLYSTCLELFKFTIGM 645

Query: 608 GELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAIS 667
           G+L F E   F+ + ++LLLAYV+LTYILLLNMLIALM ETVN +A +S +IWKLQ+AI+
Sbjct: 646 GDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAIT 705

Query: 668 VLEMENGYWWC-RKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPS 726
           +L+ E  +  C RK  R+G +L VG  PDG  D RWCFRV+EVNW +W   +  + EDP 
Sbjct: 706 ILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPG 765

Query: 727 GA-GVPRTLENPVLASPPKEDEDGASEENYVPVQLLQ 762
              GV RTL   + +S       G   +N+  V LL+
Sbjct: 766 NCEGVKRTLSFSLRSS----RVSGRHWKNFALVPLLR 798


>gi|74315350 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score =  631 bits (1627), Expect = 0.0
 Identities = 343/697 (49%), Positives = 464/697 (66%), Gaps = 19/697 (2%)

Query: 74  FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 133
           +DR  +F AV++   +DL  L  +L K+ K+LTD+E+ +  TGKTCL+KA+LNL DG N 
Sbjct: 113 YDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNT 172

Query: 134 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 193
            I  LL+I R + + + LVNA  TD YY+G +ALHIAIE+R++  V LLVENGA+V A A
Sbjct: 173 TIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 232

Query: 194 CGRFFQKGQGTC-FYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 252
            G FF+K +G   FYFGELPLSLAACT Q  +V +LL+N  Q A + A DS GNTVLHAL
Sbjct: 233 HGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHAL 292

Query: 253 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 312
           V ++DN+A+N   VTSMY+ +L  GA+L PT++LE++ N + +TPL LAA  GKI +  +
Sbjct: 293 VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAY 352

Query: 313 ILQREFSG--LSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHC-KSPHRHR 369
           ILQRE       HLSRKFTEW YGPV  SLYDL+ +D+CE+NSVLE+IA+   ++P+RH 
Sbjct: 353 ILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHD 412

Query: 370 MVVLEPLNKLLQAKWDLLIPK-FFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAE-V 427
           M+++EPLN+LLQ KWD  + + F+ NFL   +YM IFT  AY++P       P  K E  
Sbjct: 413 MLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV---DGLPPFKMEKT 469

Query: 428 GNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVL 487
           G+   +TG IL +LGG+Y     + YF +R   +   F+DSY E+LF  Q+L  + + VL
Sbjct: 470 GDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529

Query: 488 CFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLF 547
            F  ++ Y+  +V +L LGW N+LYYTRGFQ  GIY+VMI+K+ILRDL RF+ +Y+VFLF
Sbjct: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589

Query: 548 GFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGM 607
           GF+ A+V+L ++      P+   +     P     D    + Y  +    LELFKFTIGM
Sbjct: 590 GFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPD----SSYNSLYSTCLELFKFTIGM 645

Query: 608 GELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAIS 667
           G+L F E   F+ + ++LLLAYV+LTYILLLNMLIALM ETVN +A +S +IWKLQ+AI+
Sbjct: 646 GDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAIT 705

Query: 668 VLEMENGYWWC-RKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPS 726
           +L+ E  +  C RK  R+G +L VG  PDG  D RWCFRV+EVNW +W   +  + EDP 
Sbjct: 706 ILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPG 765

Query: 727 GA-GVPRTLENPVLASPPKEDEDGASEENYVPVQLLQ 762
              GV RTL   + +S       G   +N+  V LL+
Sbjct: 766 NCEGVKRTLSFSLRSS----RVSGRHWKNFALVPLLR 798


>gi|74315348 transient receptor potential cation channel, subfamily
           V, member 1 [Homo sapiens]
          Length = 839

 Score =  631 bits (1627), Expect = 0.0
 Identities = 343/697 (49%), Positives = 464/697 (66%), Gaps = 19/697 (2%)

Query: 74  FDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNA 133
           +DR  +F AV++   +DL  L  +L K+ K+LTD+E+ +  TGKTCL+KA+LNL DG N 
Sbjct: 113 YDRRSIFEAVAQNNCQDLESLLLFLQKSKKHLTDNEFKDPETGKTCLLKAMLNLHDGQNT 172

Query: 134 CILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARA 193
            I  LL+I R + + + LVNA  TD YY+G +ALHIAIE+R++  V LLVENGA+V A A
Sbjct: 173 TIPLLLEIARQTDSLKELVNASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAA 232

Query: 194 CGRFFQKGQGTC-FYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHAL 252
            G FF+K +G   FYFGELPLSLAACT Q  +V +LL+N  Q A + A DS GNTVLHAL
Sbjct: 233 HGDFFKKTKGRPGFYFGELPLSLAACTNQLGIVKFLLQNSWQTADISARDSVGNTVLHAL 292

Query: 253 VMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRH 312
           V ++DN+A+N   VTSMY+ +L  GA+L PT++LE++ N + +TPL LAA  GKI +  +
Sbjct: 293 VEVADNTADNTKFVTSMYNEILMLGAKLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAY 352

Query: 313 ILQREFSG--LSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHC-KSPHRHR 369
           ILQRE       HLSRKFTEW YGPV  SLYDL+ +D+CE+NSVLE+IA+   ++P+RH 
Sbjct: 353 ILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHD 412

Query: 370 MVVLEPLNKLLQAKWDLLIPK-FFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAE-V 427
           M+++EPLN+LLQ KWD  + + F+ NFL   +YM IFT  AY++P       P  K E  
Sbjct: 413 MLLVEPLNRLLQDKWDRFVKRIFYFNFLVYCLYMIIFTMAAYYRPV---DGLPPFKMEKT 469

Query: 428 GNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVL 487
           G+   +TG IL +LGG+Y     + YF +R   +   F+DSY E+LF  Q+L  + + VL
Sbjct: 470 GDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVL 529

Query: 488 CFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLF 547
            F  ++ Y+  +V +L LGW N+LYYTRGFQ  GIY+VMI+K+ILRDL RF+ +Y+VFLF
Sbjct: 530 YFSHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYIVFLF 589

Query: 548 GFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGM 607
           GF+ A+V+L ++      P+   +     P     D    + Y  +    LELFKFTIGM
Sbjct: 590 GFSTAVVTLIEDGKNDSLPSESTSHRWRGPACRPPD----SSYNSLYSTCLELFKFTIGM 645

Query: 608 GELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAIS 667
           G+L F E   F+ + ++LLLAYV+LTYILLLNMLIALM ETVN +A +S +IWKLQ+AI+
Sbjct: 646 GDLEFTENYDFKAVFIILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAIT 705

Query: 668 VLEMENGYWWC-RKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPS 726
           +L+ E  +  C RK  R+G +L VG  PDG  D RWCFRV+EVNW +W   +  + EDP 
Sbjct: 706 ILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPG 765

Query: 727 GA-GVPRTLENPVLASPPKEDEDGASEENYVPVQLLQ 762
              GV RTL   + +S       G   +N+  V LL+
Sbjct: 766 NCEGVKRTLSFSLRSS----RVSGRHWKNFALVPLLR 798


>gi|22547184 transient receptor potential cation channel, subfamily
           V, member 4 isoform a [Homo sapiens]
          Length = 871

 Score =  554 bits (1428), Expect = e-157
 Identities = 314/669 (46%), Positives = 421/669 (62%), Gaps = 17/669 (2%)

Query: 66  ASQPDP--NRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKA 123
           A QP P    F+R  LF+ VSRG   DL GL  +L    K LTD E+ E STGKTCL KA
Sbjct: 139 APQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKA 198

Query: 124 VLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLV 183
           +LNL +G N  I  LL I   +GN +  +N+   D YYRG +ALHIAIE+R    V+LLV
Sbjct: 199 LLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLV 258

Query: 184 ENGANVHARACGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATD 242
             GA+VHA+A GRFFQ K +G  FYFGELPLSLAACT Q  +V+YL ENPH+ A ++  D
Sbjct: 259 AQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQD 318

Query: 243 SQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAA 302
           S+GNTVLHALV I+DN+ EN   VT MYD LL   ARL P   LE + N   L+PL +AA
Sbjct: 319 SRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDSNLEAVLNNDGLSPLMMAA 378

Query: 303 KEGKIEIFRHILQREFS--GLSHLSRKFTEWCYGPVRVSLYDLASVDSC-EENSVLEIIA 359
           K GKI IF+HI++RE +     HLSRKF +W YGPV  SLYDL+S+D+C EE SVLEI+ 
Sbjct: 379 KTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYDLSSLDTCGEEASVLEILV 438

Query: 360 FHCKSPHRHRMVVLEPLNKLLQAKWDLL-IPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQ 418
           ++ K  +RH M+ +EP+N+LL+ KW       F++N +  L  M IFT  AY+QP   + 
Sbjct: 439 YNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPL--EG 496

Query: 419 AAPHLKAEVGNSMLLTGHILILLGGIYLLVGQLW-YFWRRHVFIWISFIDSYFEILFLFQ 477
             P+      + + L G ++ L  G+      +   F ++   +   FID  F++L+   
Sbjct: 497 TPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIY 556

Query: 478 ALLTVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLR 537
           ++L +VS  L    IE YL ++V ALVLGW+N LY+TRG + TG YS+MIQK++ +DL R
Sbjct: 557 SVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFR 616

Query: 538 FLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEAS 597
           FLL+YL+F+ G+A ALVSL       +         +V       D    + +       
Sbjct: 617 FLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTF------L 670

Query: 598 LELFKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSW 657
           L+LFK TIGMG+L       +  + ++LL+ Y++LT++LLLNMLIALM ETV  V+ +S 
Sbjct: 671 LDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESK 730

Query: 658 SIWKLQKAISVLEMENGY-WWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQ 716
            IWKLQ A ++L++E  +  + RK  R+G M+TVG   DG+PD RWCFRV+EVNW+ W Q
Sbjct: 731 HIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQ 790

Query: 717 TLPTLCEDP 725
            L  + EDP
Sbjct: 791 NLGIINEDP 799


>gi|22547180 transient receptor potential cation channel, subfamily
           V, member 4 isoform b [Homo sapiens]
          Length = 811

 Score =  443 bits (1139), Expect = e-124
 Identities = 275/666 (41%), Positives = 374/666 (56%), Gaps = 71/666 (10%)

Query: 66  ASQPDP--NRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKA 123
           A QP P    F+R  LF+ VSRG   DL GL  +L    K LTD E+ E STGKTCL KA
Sbjct: 139 APQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRLTDEEFREPSTGKTCLPKA 198

Query: 124 VLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLV 183
           +LNL +G N  I  LL I   +GN +  +N+   D YYRG +ALHIAIE+R    V+LLV
Sbjct: 199 LLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQTALHIAIERRCKHYVELLV 258

Query: 184 ENGANVHARACGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATD 242
             GA+VHA+A GRFFQ K +G  FYFGELPLSLAACT Q  +V+YL ENPH+ A ++  D
Sbjct: 259 AQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHIVNYLTENPHKKADMRRQD 318

Query: 243 SQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAA 302
           S+GNTVLHALV I+DN+ EN   VT MY                       DL  LK A 
Sbjct: 319 SRGNTVLHALVAIADNTRENTKFVTKMY-----------------------DLLLLKCA- 354

Query: 303 KEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHC 362
                                  R F +           +L +V + +  S L + A   
Sbjct: 355 -----------------------RLFPD----------SNLEAVLNNDGLSPLMMAAKTG 381

Query: 363 KSPHRHRMVVLEPLNKLLQAKWDLL-IPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAAP 421
           K  +RH M+ +EP+N+LL+ KW       F++N +  L  M IFT  AY+QP   +   P
Sbjct: 382 KIGNRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLCAMVIFTLTAYYQPL--EGTPP 439

Query: 422 HLKAEVGNSMLLTGHILILLGGIYLLVGQLW-YFWRRHVFIWISFIDSYFEILFLFQALL 480
           +      + + L G ++ L  G+      +   F ++   +   FID  F++L+   ++L
Sbjct: 440 YPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGVNSLFIDGSFQLLYFIYSVL 499

Query: 481 TVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLL 540
            +VS  L    IE YL ++V ALVLGW+N LY+TRG + TG YS+MIQK++ +DL RFLL
Sbjct: 500 VIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTGTYSIMIQKILFKDLFRFLL 559

Query: 541 IYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLEL 600
           +YL+F+ G+A ALVSL       +         +V       D    + +       L+L
Sbjct: 560 VYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSCRDSETFSTF------LLDL 613

Query: 601 FKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIW 660
           FK TIGMG+L       +  + ++LL+ Y++LT++LLLNMLIALM ETV  V+ +S  IW
Sbjct: 614 FKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGETVGQVSKESKHIW 673

Query: 661 KLQKAISVLEMENGY-WWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLP 719
           KLQ A ++L++E  +  + RK  R+G M+TVG   DG+PD RWCFRV+EVNW+ W Q L 
Sbjct: 674 KLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRVDEVNWSHWNQNLG 733

Query: 720 TLCEDP 725
            + EDP
Sbjct: 734 IINEDP 739


>gi|21735483 transient receptor potential cation channel, subfamily
           V, member 3 [Homo sapiens]
          Length = 790

 Score =  433 bits (1113), Expect = e-121
 Identities = 270/667 (40%), Positives = 376/667 (56%), Gaps = 50/667 (7%)

Query: 76  RDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEY--------TEGSTGKTCLMKAVLNL 127
           + R+F AVS G  E+L  L   L +  +   D +         T   TGKTCLMKA+LN+
Sbjct: 120 KKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNI 179

Query: 128 KDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGA 187
                  +  LL    ++      +NA+ T++ Y G +AL+IAIE+R      LL+  GA
Sbjct: 180 NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGA 239

Query: 188 NVHARACGRFFQ-KGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGN 246
           +V+A A G FF  K Q   FYFGE PL+LAACT Q ++V  L+E  H+   + + DS+GN
Sbjct: 240 DVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLME--HEQTDITSRDSRGN 297

Query: 247 TVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGK 306
            +LHALV ++++       V  MYD +L          +LE  RN   LTPL+LAAK GK
Sbjct: 298 NILHALVTVAEDFKTQNDFVKRMYDMILLRSGNW----ELETTRNNDGLTPLQLAAKMGK 353

Query: 307 IEIFRHILQREFSG--LSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHCKS 364
            EI ++IL RE     L  LSRKFT+W YGPV  SLYDL +VD+  +NSVLEI  ++   
Sbjct: 354 AEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNI 413

Query: 365 PHRHRMVVLEPLNKLLQAKWDLLIPK-FFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPH- 422
            +RH M+ LEPL+ LL  KW       FFL+F     Y    T V+Y++P  +++A PH 
Sbjct: 414 DNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPR-EEEAIPHP 472

Query: 423 --LKAEVGNSMLLTGHILILLGGIYLLVGQ-LWYFWRRHVFIWISFIDSYFEILFLFQAL 479
             L  ++G   LL G + +L+  + + V + +  F  R   +     D++F  +F  QA+
Sbjct: 473 LALTHKMGWLQLL-GRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAV 531

Query: 480 LTVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFL 539
           L ++S  L   A + YL  LV A+ LGW N+LYYTRGFQ  G+YSVMIQKVIL D+L+FL
Sbjct: 532 LVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFL 591

Query: 540 LIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLE 599
            +Y+VFL GF VAL SL ++                      +D  + + Y    +A LE
Sbjct: 592 FVYIVFLLGFGVALASLIEKC--------------------PKDNKDCSSYGSFSDAVLE 631

Query: 600 LFKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSI 659
           LFK TIG+G+L  Q+   +  + L LL+ YV+LT++LLLNMLIALM ETV +V+ +S  I
Sbjct: 632 LFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERI 691

Query: 660 WKLQKAISVLEMENGY-WWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTL 718
           W+LQ+A ++LE E     W R + R G +  V        D R C R+ EV W  W+  +
Sbjct: 692 WRLQRARTILEFEKMLPEWLRSRFRMGELCKV-----AEDDFRLCLRINEVKWTEWKTHV 746

Query: 719 PTLCEDP 725
             L EDP
Sbjct: 747 SFLNEDP 753


>gi|21314682 transient receptor potential cation channel, subfamily
           V, member 6 [Homo sapiens]
          Length = 725

 Score =  225 bits (574), Expect = 1e-58
 Identities = 184/630 (29%), Positives = 300/630 (47%), Gaps = 74/630 (11%)

Query: 98  LSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCT 157
           L+K  KY     +  G+ G+T L  A L   D + A ++ +         P+ LV    T
Sbjct: 61  LNKLLKYEDCKVHQRGAMGETALHIAALY--DNLEAAMVLM------EAAPE-LVFEPMT 111

Query: 158 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 217
            + Y G +ALHIA+  +++  V+ L+   A+V ARA G  F++      YFGE PLS AA
Sbjct: 112 SELYEGQTALHIAVVNQNMNLVRALLARRASVSARATGTAFRRSPCNLIYFGEHPLSFAA 171

Query: 218 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAG 277
           C    ++V  L+E+    A ++A DS GNTVLH L++       N      MY+ LL   
Sbjct: 172 CVNSEEIVRLLIEHG---ADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYD 223

Query: 278 ARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVR 337
                   L+ + N Q LTP KLA  EG   +F+H++Q+         RK T+W YGP+ 
Sbjct: 224 RHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQK---------RKHTQWTYGPLT 274

Query: 338 VSLYDLASVDSC-EENSVLEIIAFHCKSPHRHRMVVLEPLNKLLQAKWDLL-IPKFFLNF 395
            +LYDL  +DS  +E S+LE+I    K     +++   P+ +L+  KW     P F +  
Sbjct: 275 STLYDLTEIDSSGDEQSLLELI-ITTKKREARQILDQTPVKELVSLKWKRYGRPYFCMLG 333

Query: 396 LCNLIYMFIFTAVAYHQPTLKK---QAAPHLKAEVGNSML------------LTGHILIL 440
              L+Y+  FT    ++P   +   + +P     +   +L            L G ++ +
Sbjct: 334 AIYLLYIICFTMCCIYRPLKPRTNNRTSPRDNTLLQQKLLQEAYMTPKDDIRLVGELVTV 393

Query: 441 LGGIYLLVGQLWYFWRRHV--FIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPL 498
           +G I +L+ ++   +R  V  F   + +   F +L +  A + +V+ V+  ++    +  
Sbjct: 394 IGAIIILLVEVPDIFRMGVTRFFGQTILGGPFHVLIITYAFMVLVTMVMRLISASGEVVP 453

Query: 499 LVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQ 558
           +  ALVLGW N++Y+ RGFQ  G +++MIQK+I  DL+RF  +  V + GFA A   + Q
Sbjct: 454 MSFALVLGWCNVMYFARGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQ 513

Query: 559 EAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHF 618
                               E  E+ G+   Y   L ++ ELF  TI  G   +   L F
Sbjct: 514 -------------------TEDPEELGHFYDYPMALFSTFELF-LTIIDGPANYNVDLPF 553

Query: 619 RGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWC 678
             M  +   A+ ++  +L+LN+LIA+M +T   VA +   +W+ Q   + + +E     C
Sbjct: 554 --MYSITYAAFAIIATLLMLNLLIAMMGDTHWRVAHERDELWRAQIVATTVMLERKLPRC 611

Query: 679 RKKQRAGVMLTVGTKPDGSPDERWCFRVEE 708
               R+G+        +    +RW  RVE+
Sbjct: 612 -LWPRSGI-----CGREYGLGDRWFLRVED 635


>gi|17505200 transient receptor potential cation channel, subfamily
           V, member 5 [Homo sapiens]
          Length = 729

 Score =  204 bits (518), Expect = 3e-52
 Identities = 178/621 (28%), Positives = 287/621 (46%), Gaps = 82/621 (13%)

Query: 113 GSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIE 172
           G+ G+T L  A L   D + A ++ +         P+ LV    T + + G +ALHIA+ 
Sbjct: 76  GALGETALHIAALY--DNLEAALVLM------EAAPE-LVFEPTTCEAFAGQTALHIAVV 126

Query: 173 KRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENP 232
            +++  V+ L+   A+V ARA G  F++      YFGE PLS AAC    ++V  L+E+ 
Sbjct: 127 NQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHG 186

Query: 233 HQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNL 292
              A ++A DS GNTVLH L++       N      MY+ LL           L+ + N 
Sbjct: 187 ---ADIRAQDSLGNTVLHILIL-----QPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNH 238

Query: 293 QDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSC-EE 351
           Q LTP KLA  EG   +F+H++Q+         R+  +W YGP+   LYDL  +DS  EE
Sbjct: 239 QGLTPFKLAGVEGNTVMFQHLMQK---------RRHIQWTYGPLTSILYDLTEIDSWGEE 289

Query: 352 NSVLEIIAFHCKSPHRHRMVVLE--PLNKLLQAKWDLL-IPKFFLNFLCNLIYMFIFTAV 408
            S LE++     S  R    +LE  P+ +L+  KW+    P F +     L+YM  FT  
Sbjct: 290 LSFLELVV---SSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTC 346

Query: 409 AYHQP--------------TLKKQAAPHLKAEVGNSML-LTGHILILLGGIYLLVGQLWY 453
             ++P              T+ +Q       E    ++ L G ++ ++G + +L+ ++  
Sbjct: 347 CVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPD 406

Query: 454 FWRRHV--FIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGWLNLL 511
            +R     +   + +   F ++ +  A L +V+ V+        +  +  ALVLGW +++
Sbjct: 407 IFRVGASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVM 466

Query: 512 YYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNA 571
           Y+TRGFQ  G +++MIQK+I  DL+RF  +  V + GFA A   + Q     E PT    
Sbjct: 467 YFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQ----TEDPT---- 518

Query: 572 TESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLLLLAYVL 631
                        G    Y   L  + ELF  T+      +   L F  M  ++  A+ +
Sbjct: 519 -----------SLGQFYDYPMALFTTFELF-LTVIDAPANYDVDLPF--MFSIVNFAFAI 564

Query: 632 LTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWC--RKKQRAGVMLT 689
           +  +L+LN+ IA+M +T   VA +   +W+ Q   + + +E     C   +    G    
Sbjct: 565 IATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFG 624

Query: 690 VGTKPDGSPDERWCFRVEEVN 710
           +G        +RW  RVE  N
Sbjct: 625 LG--------DRWFLRVENHN 637


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 49/158 (31%), Positives = 74/158 (46%), Gaps = 32/158 (20%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           RG +ALH+A      + V+ LV++GA V A+A                + PL ++A   +
Sbjct: 465 RGETALHMAARSGQAEVVRYLVQDGAQVEAKAKD-------------DQTPLHISARLGK 511

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLC 281
            D+V  LL+   Q AS  A  + G T LH   + +    E++A        LL  GA L 
Sbjct: 512 ADIVQQLLQ---QGASPNAATTSGYTPLH---LSAREGHEDVAAF------LLDHGASLS 559

Query: 282 PTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFS 319
            T +       +  TPL +AAK GK+E+   +LQ+  S
Sbjct: 560 ITTK-------KGFTPLHVAAKYGKLEVANLLLQKSAS 590



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 46/165 (27%), Positives = 73/165 (44%), Gaps = 23/165 (13%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G++ALHIA      + VK+LV NGANV+A++   F              PL +AA    
Sbjct: 106 KGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGF-------------TPLYMAAQENH 152

Query: 222 WDVVSYLLENPHQPA--------SLQATDSQGNTVLHALVMISDNSAE--NIALVTSMYD 271
            +VV +LL+N    +         L     QG+  + +L++ +D   +    AL  +   
Sbjct: 153 LEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARK 212

Query: 272 GLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
              +A A L       D+ +    TPL +AA  G I +   +L R
Sbjct: 213 DDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNR 257



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 42/154 (27%), Positives = 74/154 (48%), Gaps = 32/154 (20%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LHIA +K  ++ ++LL+++GA++ A                 G  P+ +AA     
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQA-------------VTESGLTPIHVAAFMGHV 446

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
           ++VS L+   H  AS   T+ +G T LH  +      AE +         L+Q GA++  
Sbjct: 447 NIVSQLM---HHGASPNTTNVRGETALH--MAARSGQAEVVRY-------LVQDGAQV-- 492

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
                + +   D TPL ++A+ GK +I + +LQ+
Sbjct: 493 -----EAKAKDDQTPLHISARLGKADIVQQLLQQ 521



 Score = 38.1 bits (87), Expect = 0.031
 Identities = 39/147 (26%), Positives = 62/147 (42%), Gaps = 32/147 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A    + +   LL++ GA+ HA A               G  PL +AA   Q 
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN-------------GYTPLHIAAKKNQM 644

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
           D+ + LLE     A   A   QG   +H  +   +   + ++L       LL   A +  
Sbjct: 645 DIATTLLE---YGADANAVTRQGIASVH--LAAQEGHVDMVSL-------LLGRNANV-- 690

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEI 309
                ++ N   LTPL LAA+E ++ +
Sbjct: 691 -----NLSNKSGLTPLHLAAQEDRVNV 712



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 40/173 (23%), Positives = 69/173 (39%), Gaps = 39/173 (22%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVH------------ARACGRF--------FQKGQ 202
           G S LH+A +   L CV+LL+++   V             A  CG +         +   
Sbjct: 334 GLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANP 393

Query: 203 GTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAEN 262
                 G  PL +A    +  V+  LL++    AS+QA    G T +H    +       
Sbjct: 394 NAKALNGFTPLHIACKKNRIKVMELLLKH---GASIQAVTESGLTPIHVAAFMGH----- 445

Query: 263 IALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
                ++   L+  GA         +  N++  T L +AA+ G+ E+ R+++Q
Sbjct: 446 ----VNIVSQLMHHGAS-------PNTTNVRGETALHMAARSGQAEVVRYLVQ 487



 Score = 33.9 bits (76), Expect = 0.58
 Identities = 40/153 (26%), Positives = 63/153 (41%), Gaps = 32/153 (20%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G++ LHIA +K  +     L+E GA+ +A                 G   + LAA     
Sbjct: 631 GYTPLHIAAKKNQMDIATTLLEYGADANA-------------VTRQGIASVHLAAQEGHV 677

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
           D+VS LL    + A++  ++  G T LH   + +     N+A V      L+  GA +  
Sbjct: 678 DMVSLLL---GRNANVNLSNKSGLTPLH---LAAQEDRVNVAEV------LVNQGAHV-- 723

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
                D +     TPL +    G I+I   +LQ
Sbjct: 724 -----DAQTKMGYTPLHVGCHYGNIKIVNFLLQ 751



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 41/158 (25%), Positives = 65/158 (41%), Gaps = 32/158 (20%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G +++H+A ++  +  V LL+   ANV+                  G  PL LAA   +
Sbjct: 663 QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKS-------------GLTPLHLAAQEDR 709

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLC 281
            +V   L+   +Q A + A    G T LH           NI +V    + LLQ  A++ 
Sbjct: 710 VNVAEVLV---NQGAHVDAQTKMGYTPLHVGCHYG-----NIKIV----NFLLQHSAKV- 756

Query: 282 PTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFS 319
                 + +     TPL  AA++G   I   +LQ   S
Sbjct: 757 ------NAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788


>gi|6912736 transient receptor potential cation channel, subfamily
           C, member 5 [Homo sapiens]
          Length = 973

 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 73/303 (24%), Positives = 128/303 (42%), Gaps = 41/303 (13%)

Query: 386 LLIPKFFLNFLCN----LIYMFIFTAVAYH--QPTLKKQAAPHLKAEVGNSMLLTGHILI 439
           L I K F+ F+C+    L ++F+    + H  +  L  Q  P    E    M+L      
Sbjct: 358 LFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEW---MILPW---- 410

Query: 440 LLGGIYLLVGQLWYF-WRRHVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIE----- 493
           +LG I+  + ++W   +  ++  W + +D     L+L    L +V+ V    +       
Sbjct: 411 VLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWE 470

Query: 494 -WYLPLLVSAL-----VLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLF 547
            W+  L+  AL     +L  L L+       H G   + + +++L D+L+FL IY + L 
Sbjct: 471 MWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVLL 529

Query: 548 GFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGM 607
            FA  L  L    +   A   PN  + ++     E + N   +  + E    LF    G+
Sbjct: 530 AFANGLNQL-YFYYETRAIDEPNNCKGIRC----EKQNNA--FSTLFETLQSLFWSVFGL 582

Query: 608 GEL------AFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWK 661
             L      A  E   F G  +     Y +++ ++LLNMLIA+M+ +   +A  +   WK
Sbjct: 583 LNLYVTNVKARHEFTEFVGATMFG--TYNVISLVVLLNMLIAMMNNSYQLIADHADIEWK 640

Query: 662 LQK 664
             +
Sbjct: 641 FAR 643


>gi|209863032 transient receptor potential cation channel, subfamily
           C, member 4 isoform zeta [Homo sapiens]
          Length = 804

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 73/304 (24%), Positives = 127/304 (41%), Gaps = 46/304 (15%)

Query: 386 LLIPKFFLNFLCN----LIYMFIFTAVAYH--QPTLKKQAAPHLKAEVGNSMLLTGHILI 439
           L I K F+ F+C+    L ++F+    + H  +  L +Q  P    E    M+L      
Sbjct: 184 LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEW---MILPW---- 236

Query: 440 LLGGIYLLVGQLWYFWRR-HVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIE----- 493
           +LG I+  + Q+W    + ++  W + +D     L+L    L +V+ V  + A+      
Sbjct: 237 VLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVK-YSALNPRESW 295

Query: 494 --WYLPLLVSAL-----VLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFL 546
             W+  L+  AL     +   L L+       H G   + + +++L D+L+FL IY + L
Sbjct: 296 DMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVL 354

Query: 547 FGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIG 606
             FA  L   +Q  +  E   G          +G   E     +  + E    LF    G
Sbjct: 355 LAFANGL---NQLYFYYEETKGLTC-------KGIRCEKQNNAFSTLFETLQSLFWSIFG 404

Query: 607 MGEL------AFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIW 660
           +  L      A  E   F G  +     Y +++ ++LLNMLIA+M+ +   +A  +   W
Sbjct: 405 LINLYVTNVKAQHEFTEFVGATMFG--TYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 462

Query: 661 KLQK 664
           K  +
Sbjct: 463 KFAR 466


>gi|209863030 transient receptor potential cation channel, subfamily
           C, member 4 isoform delta [Homo sapiens]
          Length = 836

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 73/304 (24%), Positives = 127/304 (41%), Gaps = 46/304 (15%)

Query: 386 LLIPKFFLNFLCN----LIYMFIFTAVAYH--QPTLKKQAAPHLKAEVGNSMLLTGHILI 439
           L I K F+ F+C+    L ++F+    + H  +  L +Q  P    E    M+L      
Sbjct: 357 LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEW---MILPW---- 409

Query: 440 LLGGIYLLVGQLWYFWRR-HVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIE----- 493
           +LG I+  + Q+W    + ++  W + +D     L+L    L +V+ V  + A+      
Sbjct: 410 VLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVK-YSALNPRESW 468

Query: 494 --WYLPLLVSAL-----VLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFL 546
             W+  L+  AL     +   L L+       H G   + + +++L D+L+FL IY + L
Sbjct: 469 DMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVL 527

Query: 547 FGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIG 606
             FA  L   +Q  +  E   G          +G   E     +  + E    LF    G
Sbjct: 528 LAFANGL---NQLYFYYEETKGLTC-------KGIRCEKQNNAFSTLFETLQSLFWSIFG 577

Query: 607 MGEL------AFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIW 660
           +  L      A  E   F G  +     Y +++ ++LLNMLIA+M+ +   +A  +   W
Sbjct: 578 LINLYVTNVKAQHEFTEFVGATMFG--TYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635

Query: 661 KLQK 664
           K  +
Sbjct: 636 KFAR 639


>gi|209863026 transient receptor potential cation channel, subfamily
           C, member 4 isoform beta [Homo sapiens]
          Length = 893

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 73/304 (24%), Positives = 127/304 (41%), Gaps = 46/304 (15%)

Query: 386 LLIPKFFLNFLCN----LIYMFIFTAVAYH--QPTLKKQAAPHLKAEVGNSMLLTGHILI 439
           L I K F+ F+C+    L ++F+    + H  +  L +Q  P    E    M+L      
Sbjct: 357 LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEW---MILPW---- 409

Query: 440 LLGGIYLLVGQLWYFWRR-HVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIE----- 493
           +LG I+  + Q+W    + ++  W + +D     L+L    L +V+ V  + A+      
Sbjct: 410 VLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVK-YSALNPRESW 468

Query: 494 --WYLPLLVSAL-----VLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFL 546
             W+  L+  AL     +   L L+       H G   + + +++L D+L+FL IY + L
Sbjct: 469 DMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVL 527

Query: 547 FGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIG 606
             FA  L   +Q  +  E   G          +G   E     +  + E    LF    G
Sbjct: 528 LAFANGL---NQLYFYYEETKGLTC-------KGIRCEKQNNAFSTLFETLQSLFWSIFG 577

Query: 607 MGEL------AFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIW 660
           +  L      A  E   F G  +     Y +++ ++LLNMLIA+M+ +   +A  +   W
Sbjct: 578 LINLYVTNVKAQHEFTEFVGATMFG--TYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635

Query: 661 KLQK 664
           K  +
Sbjct: 636 KFAR 639


>gi|209863024 transient receptor potential cation channel, subfamily
           C, member 4 isoform epsilon [Homo sapiens]
          Length = 982

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 73/304 (24%), Positives = 127/304 (41%), Gaps = 46/304 (15%)

Query: 386 LLIPKFFLNFLCN----LIYMFIFTAVAYH--QPTLKKQAAPHLKAEVGNSMLLTGHILI 439
           L I K F+ F+C+    L ++F+    + H  +  L +Q  P    E    M+L      
Sbjct: 357 LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEW---MILPW---- 409

Query: 440 LLGGIYLLVGQLWYFWRR-HVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIE----- 493
           +LG I+  + Q+W    + ++  W + +D     L+L    L +V+ V  + A+      
Sbjct: 410 VLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVK-YSALNPRESW 468

Query: 494 --WYLPLLVSAL-----VLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFL 546
             W+  L+  AL     +   L L+       H G   + + +++L D+L+FL IY + L
Sbjct: 469 DMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVL 527

Query: 547 FGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIG 606
             FA  L   +Q  +  E   G          +G   E     +  + E    LF    G
Sbjct: 528 LAFANGL---NQLYFYYEETKGLTC-------KGIRCEKQNNAFSTLFETLQSLFWSIFG 577

Query: 607 MGEL------AFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIW 660
           +  L      A  E   F G  +     Y +++ ++LLNMLIA+M+ +   +A  +   W
Sbjct: 578 LINLYVTNVKAQHEFTEFVGATMFG--TYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635

Query: 661 KLQK 664
           K  +
Sbjct: 636 KFAR 639


>gi|7706747 transient receptor potential cation channel, subfamily
           C, member 4 isoform alpha [Homo sapiens]
          Length = 977

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 73/304 (24%), Positives = 127/304 (41%), Gaps = 46/304 (15%)

Query: 386 LLIPKFFLNFLCN----LIYMFIFTAVAYH--QPTLKKQAAPHLKAEVGNSMLLTGHILI 439
           L I K F+ F+C+    L ++F+    + H  +  L +Q  P    E    M+L      
Sbjct: 357 LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEW---MILPW---- 409

Query: 440 LLGGIYLLVGQLWYFWRR-HVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIE----- 493
           +LG I+  + Q+W    + ++  W + +D     L+L    L +V+ V  + A+      
Sbjct: 410 VLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVK-YSALNPRESW 468

Query: 494 --WYLPLLVSAL-----VLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFL 546
             W+  L+  AL     +   L L+       H G   + + +++L D+L+FL IY + L
Sbjct: 469 DMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVL 527

Query: 547 FGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIG 606
             FA  L   +Q  +  E   G          +G   E     +  + E    LF    G
Sbjct: 528 LAFANGL---NQLYFYYEETKGLTC-------KGIRCEKQNNAFSTLFETLQSLFWSIFG 577

Query: 607 MGEL------AFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIW 660
           +  L      A  E   F G  +     Y +++ ++LLNMLIA+M+ +   +A  +   W
Sbjct: 578 LINLYVTNVKAQHEFTEFVGATMFG--TYNVISLVVLLNMLIAMMNNSYQLIADHADIEW 635

Query: 661 KLQK 664
           K  +
Sbjct: 636 KFAR 639


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 45/155 (29%), Positives = 72/155 (46%), Gaps = 32/155 (20%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           RG +ALH+A     ++ V+ L+ NGA V ARA                + PL +A+   +
Sbjct: 442 RGETALHMAARAGQVEVVRCLLRNGALVDARAREE-------------QTPLHIASRLGK 488

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLC 281
            ++V  LL++   P    A  + G T LH       ++ E    V S+   LL+AGA   
Sbjct: 489 TEIVQLLLQHMAHP---DAATTNGYTPLHI------SAREGQVDVASV---LLEAGA--- 533

Query: 282 PTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
                  +   +  TPL +AAK G +++ + +LQR
Sbjct: 534 ----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 564



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 55/188 (29%), Positives = 86/188 (45%), Gaps = 41/188 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LHIA +K  ++ ++LLV+ GA++ A                 G  P+ +AA     
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQA-------------ITESGLTPIHVAAFMGHL 423

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
           ++V  LL+N    AS   T+ +G T LH         A  + +V      LL+ GA    
Sbjct: 424 NIVLLLLQN---GASPDVTNIRGETALHMAA-----RAGQVEVVRC----LLRNGA---- 467

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSL-- 340
              L D R  ++ TPL +A++ GK EI + +LQ     ++H     T   Y P+ +S   
Sbjct: 468 ---LVDARAREEQTPLHIASRLGKTEIVQLLLQH----MAHPDAATTNG-YTPLHISARE 519

Query: 341 --YDLASV 346
              D+ASV
Sbjct: 520 GQVDVASV 527



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 43/151 (28%), Positives = 68/151 (45%), Gaps = 32/151 (21%)

Query: 165 SALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDV 224
           +ALH+A      +  KLL++  AN +ARA   F              PL +A    +  V
Sbjct: 346 TALHVAAHCGHYRVTKLLLDKRANPNARALNGF-------------TPLHIACKKNRIKV 392

Query: 225 VSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTV 284
           +  L++     AS+QA    G T +H    +      NI L+      LLQ GA      
Sbjct: 393 MELLVK---YGASIQAITESGLTPIHVAAFMGH---LNIVLL------LLQNGAS----- 435

Query: 285 QLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
              D+ N++  T L +AA+ G++E+ R +L+
Sbjct: 436 --PDVTNIRGETALHMAARAGQVEVVRCLLR 464



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 35/104 (33%), Positives = 48/104 (46%), Gaps = 16/104 (15%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G++ALHIA      + VK+LV+ GAN++A++   F              PL +AA    
Sbjct: 75  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF-------------TPLYMAAQENH 121

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIAL 265
            DVV YLLEN    A+       G T L   +    N A  I L
Sbjct: 122 IDVVKYLLEN---GANQSTATEDGFTPLAVALQQGHNQAVAILL 162



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 47/190 (24%), Positives = 74/190 (38%), Gaps = 36/190 (18%)

Query: 128 KDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGA 187
           KD   +  L LLQ D ++     ++  + T+    G + LHIA    ++    LL+  GA
Sbjct: 181 KDDTKSAAL-LLQNDHNADVQSKMMVNRTTES---GFTPLHIAAHYGNVNVATLLLNRGA 236

Query: 188 NVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNT 247
            V   A               G  PL +A+     ++V  LL+   Q   + A    G T
Sbjct: 237 AVDFTARN-------------GITPLHVASKRGNTNMVKLLLDRGGQ---IDAKTRDGLT 280

Query: 248 VLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKI 307
            LH       +    +         LL+ GA L         R    L+PL +AA+   +
Sbjct: 281 PLHCAARSGHDQVVEL---------LLERGAPLLA-------RTKNGLSPLHMAAQGDHV 324

Query: 308 EIFRHILQRE 317
           E  +H+LQ +
Sbjct: 325 ECVKHLLQHK 334



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 43/147 (29%), Positives = 57/147 (38%), Gaps = 32/147 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A    + +   LL+E GA+ HA A               G  PL +AA   Q 
Sbjct: 575 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKN-------------GYTPLHIAAKKNQM 621

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
            + S LL   +  A       QG T LH        S E     T M   LL  GA +  
Sbjct: 622 QIASTLL---NYGAETNIVTKQGVTPLHLA------SQEG---HTDMVTLLLDKGANI-- 667

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEI 309
                 +     LT L LAA+E K+ +
Sbjct: 668 -----HMSTKSGLTSLHLAAQEDKVNV 689



 Score = 33.9 bits (76), Expect = 0.58
 Identities = 45/155 (29%), Positives = 66/155 (42%), Gaps = 32/155 (20%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G + LH+A +  SL   KLL++  A   A + G+            G  PL +AA    
Sbjct: 541 KGFTPLHVAAKYGSLDVAKLLLQRRA--AADSAGK-----------NGLTPLHVAAHYDN 587

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLC 281
             V   LLE   + AS  AT   G T LH        + +N   + S    LL  GA   
Sbjct: 588 QKVALLLLE---KGASPHATAKNGYTPLHIA------AKKNQMQIAST---LLNYGAE-- 633

Query: 282 PTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
                 +I   Q +TPL LA++EG  ++   +L +
Sbjct: 634 -----TNIVTKQGVTPLHLASQEGHTDMVTLLLDK 663



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 39/167 (23%), Positives = 66/167 (39%), Gaps = 27/167 (16%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A ++ +   VKLL++ G  + A+                G  PL  AA +   
Sbjct: 245 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD-------------GLTPLHCAARSGHD 291

Query: 223 DVVSYLLE----------NPHQPASLQATDSQGNTVLHAL---VMISDNSAENI-ALVTS 268
            VV  LLE          N   P  + A       V H L     + D + + + AL  +
Sbjct: 292 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 351

Query: 269 MYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
            + G  +    L       + R L   TPL +A K+ +I++   +++
Sbjct: 352 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 398



 Score = 30.0 bits (66), Expect = 8.4
 Identities = 37/154 (24%), Positives = 61/154 (39%), Gaps = 32/154 (20%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G + LH+A ++     V LL++ GAN+H                  G   L LAA   +
Sbjct: 640 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS-------------GLTSLHLAAQEDK 686

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLC 281
            +V   L ++          D   +T L    +I      N+ +V    + LL+ GA + 
Sbjct: 687 VNVADILTKH--------GADQDAHTKLGYTPLIVACHYGNVKMV----NFLLKQGANV- 733

Query: 282 PTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
                 + +     TPL  AA++G   I   +LQ
Sbjct: 734 ------NAKTKNGYTPLHQAAQQGHTHIINVLLQ 761


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 45/155 (29%), Positives = 72/155 (46%), Gaps = 32/155 (20%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           RG +ALH+A     ++ V+ L+ NGA V ARA                + PL +A+   +
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREE-------------QTPLHIASRLGK 509

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLC 281
            ++V  LL++   P    A  + G T LH       ++ E    V S+   LL+AGA   
Sbjct: 510 TEIVQLLLQHMAHP---DAATTNGYTPLHI------SAREGQVDVASV---LLEAGA--- 554

Query: 282 PTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
                  +   +  TPL +AAK G +++ + +LQR
Sbjct: 555 ----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 55/188 (29%), Positives = 86/188 (45%), Gaps = 41/188 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LHIA +K  ++ ++LLV+ GA++ A                 G  P+ +AA     
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQA-------------ITESGLTPIHVAAFMGHL 444

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
           ++V  LL+N    AS   T+ +G T LH         A  + +V      LL+ GA    
Sbjct: 445 NIVLLLLQN---GASPDVTNIRGETALHMAA-----RAGQVEVVRC----LLRNGA---- 488

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSL-- 340
              L D R  ++ TPL +A++ GK EI + +LQ     ++H     T   Y P+ +S   
Sbjct: 489 ---LVDARAREEQTPLHIASRLGKTEIVQLLLQH----MAHPDAATTNG-YTPLHISARE 540

Query: 341 --YDLASV 346
              D+ASV
Sbjct: 541 GQVDVASV 548



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 43/151 (28%), Positives = 68/151 (45%), Gaps = 32/151 (21%)

Query: 165 SALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDV 224
           +ALH+A      +  KLL++  AN +ARA   F              PL +A    +  V
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGF-------------TPLHIACKKNRIKV 413

Query: 225 VSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTV 284
           +  L++     AS+QA    G T +H    +      NI L+      LLQ GA      
Sbjct: 414 MELLVK---YGASIQAITESGLTPIHVAAFMGH---LNIVLL------LLQNGAS----- 456

Query: 285 QLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
              D+ N++  T L +AA+ G++E+ R +L+
Sbjct: 457 --PDVTNIRGETALHMAARAGQVEVVRCLLR 485



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 35/104 (33%), Positives = 48/104 (46%), Gaps = 16/104 (15%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G++ALHIA      + VK+LV+ GAN++A++   F              PL +AA    
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF-------------TPLYMAAQENH 142

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIAL 265
            DVV YLLEN    A+       G T L   +    N A  I L
Sbjct: 143 IDVVKYLLEN---GANQSTATEDGFTPLAVALQQGHNQAVAILL 183



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 47/190 (24%), Positives = 74/190 (38%), Gaps = 36/190 (18%)

Query: 128 KDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGA 187
           KD   +  L LLQ D ++     ++  + T+    G + LHIA    ++    LL+  GA
Sbjct: 202 KDDTKSAAL-LLQNDHNADVQSKMMVNRTTES---GFTPLHIAAHYGNVNVATLLLNRGA 257

Query: 188 NVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNT 247
            V   A               G  PL +A+     ++V  LL+   Q   + A    G T
Sbjct: 258 AVDFTARN-------------GITPLHVASKRGNTNMVKLLLDRGGQ---IDAKTRDGLT 301

Query: 248 VLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKI 307
            LH       +    +         LL+ GA L         R    L+PL +AA+   +
Sbjct: 302 PLHCAARSGHDQVVEL---------LLERGAPLLA-------RTKNGLSPLHMAAQGDHV 345

Query: 308 EIFRHILQRE 317
           E  +H+LQ +
Sbjct: 346 ECVKHLLQHK 355



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 43/147 (29%), Positives = 57/147 (38%), Gaps = 32/147 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A    + +   LL+E GA+ HA A               G  PL +AA   Q 
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKN-------------GYTPLHIAAKKNQM 642

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
            + S LL   +  A       QG T LH        S E     T M   LL  GA +  
Sbjct: 643 QIASTLL---NYGAETNIVTKQGVTPLHLA------SQEG---HTDMVTLLLDKGANI-- 688

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEI 309
                 +     LT L LAA+E K+ +
Sbjct: 689 -----HMSTKSGLTSLHLAAQEDKVNV 710



 Score = 33.9 bits (76), Expect = 0.58
 Identities = 45/155 (29%), Positives = 66/155 (42%), Gaps = 32/155 (20%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G + LH+A +  SL   KLL++  A   A + G+            G  PL +AA    
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRA--AADSAGK-----------NGLTPLHVAAHYDN 608

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLC 281
             V   LLE   + AS  AT   G T LH        + +N   + S    LL  GA   
Sbjct: 609 QKVALLLLE---KGASPHATAKNGYTPLHIA------AKKNQMQIAST---LLNYGAE-- 654

Query: 282 PTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
                 +I   Q +TPL LA++EG  ++   +L +
Sbjct: 655 -----TNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 39/167 (23%), Positives = 66/167 (39%), Gaps = 27/167 (16%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A ++ +   VKLL++ G  + A+                G  PL  AA +   
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD-------------GLTPLHCAARSGHD 312

Query: 223 DVVSYLLE----------NPHQPASLQATDSQGNTVLHAL---VMISDNSAENI-ALVTS 268
            VV  LLE          N   P  + A       V H L     + D + + + AL  +
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372

Query: 269 MYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
            + G  +    L       + R L   TPL +A K+ +I++   +++
Sbjct: 373 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 419



 Score = 30.0 bits (66), Expect = 8.4
 Identities = 37/154 (24%), Positives = 61/154 (39%), Gaps = 32/154 (20%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G + LH+A ++     V LL++ GAN+H                  G   L LAA   +
Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS-------------GLTSLHLAAQEDK 707

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLC 281
            +V   L ++          D   +T L    +I      N+ +V    + LL+ GA + 
Sbjct: 708 VNVADILTKH--------GADQDAHTKLGYTPLIVACHYGNVKMV----NFLLKQGANV- 754

Query: 282 PTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
                 + +     TPL  AA++G   I   +LQ
Sbjct: 755 ------NAKTKNGYTPLHQAAQQGHTHIINVLLQ 782


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 45/155 (29%), Positives = 72/155 (46%), Gaps = 32/155 (20%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           RG +ALH+A     ++ V+ L+ NGA V ARA                + PL +A+   +
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREE-------------QTPLHIASRLGK 509

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLC 281
            ++V  LL++   P    A  + G T LH       ++ E    V S+   LL+AGA   
Sbjct: 510 TEIVQLLLQHMAHP---DAATTNGYTPLHI------SAREGQVDVASV---LLEAGA--- 554

Query: 282 PTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
                  +   +  TPL +AAK G +++ + +LQR
Sbjct: 555 ----AHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 55/188 (29%), Positives = 86/188 (45%), Gaps = 41/188 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LHIA +K  ++ ++LLV+ GA++ A                 G  P+ +AA     
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQA-------------ITESGLTPIHVAAFMGHL 444

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
           ++V  LL+N    AS   T+ +G T LH         A  + +V      LL+ GA    
Sbjct: 445 NIVLLLLQN---GASPDVTNIRGETALHMAA-----RAGQVEVVRC----LLRNGA---- 488

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSL-- 340
              L D R  ++ TPL +A++ GK EI + +LQ     ++H     T   Y P+ +S   
Sbjct: 489 ---LVDARAREEQTPLHIASRLGKTEIVQLLLQH----MAHPDAATTNG-YTPLHISARE 540

Query: 341 --YDLASV 346
              D+ASV
Sbjct: 541 GQVDVASV 548



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 43/151 (28%), Positives = 68/151 (45%), Gaps = 32/151 (21%)

Query: 165 SALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDV 224
           +ALH+A      +  KLL++  AN +ARA   F              PL +A    +  V
Sbjct: 367 TALHVAAHCGHYRVTKLLLDKRANPNARALNGF-------------TPLHIACKKNRIKV 413

Query: 225 VSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTV 284
           +  L++     AS+QA    G T +H    +      NI L+      LLQ GA      
Sbjct: 414 MELLVK---YGASIQAITESGLTPIHVAAFMGH---LNIVLL------LLQNGAS----- 456

Query: 285 QLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
              D+ N++  T L +AA+ G++E+ R +L+
Sbjct: 457 --PDVTNIRGETALHMAARAGQVEVVRCLLR 485



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 35/104 (33%), Positives = 48/104 (46%), Gaps = 16/104 (15%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G++ALHIA      + VK+LV+ GAN++A++   F              PL +AA    
Sbjct: 96  KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGF-------------TPLYMAAQENH 142

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIAL 265
            DVV YLLEN    A+       G T L   +    N A  I L
Sbjct: 143 IDVVKYLLEN---GANQSTATEDGFTPLAVALQQGHNQAVAILL 183



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 47/190 (24%), Positives = 74/190 (38%), Gaps = 36/190 (18%)

Query: 128 KDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGA 187
           KD   +  L LLQ D ++     ++  + T+    G + LHIA    ++    LL+  GA
Sbjct: 202 KDDTKSAAL-LLQNDHNADVQSKMMVNRTTES---GFTPLHIAAHYGNVNVATLLLNRGA 257

Query: 188 NVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNT 247
            V   A               G  PL +A+     ++V  LL+   Q   + A    G T
Sbjct: 258 AVDFTARN-------------GITPLHVASKRGNTNMVKLLLDRGGQ---IDAKTRDGLT 301

Query: 248 VLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKI 307
            LH       +    +         LL+ GA L         R    L+PL +AA+   +
Sbjct: 302 PLHCAARSGHDQVVEL---------LLERGAPLLA-------RTKNGLSPLHMAAQGDHV 345

Query: 308 EIFRHILQRE 317
           E  +H+LQ +
Sbjct: 346 ECVKHLLQHK 355



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 43/147 (29%), Positives = 57/147 (38%), Gaps = 32/147 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A    + +   LL+E GA+ HA A               G  PL +AA   Q 
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKN-------------GYTPLHIAAKKNQM 642

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
            + S LL   +  A       QG T LH        S E     T M   LL  GA +  
Sbjct: 643 QIASTLL---NYGAETNIVTKQGVTPLHLA------SQEG---HTDMVTLLLDKGANI-- 688

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEI 309
                 +     LT L LAA+E K+ +
Sbjct: 689 -----HMSTKSGLTSLHLAAQEDKVNV 710



 Score = 33.9 bits (76), Expect = 0.58
 Identities = 45/155 (29%), Positives = 66/155 (42%), Gaps = 32/155 (20%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G + LH+A +  SL   KLL++  A   A + G+            G  PL +AA    
Sbjct: 562 KGFTPLHVAAKYGSLDVAKLLLQRRA--AADSAGK-----------NGLTPLHVAAHYDN 608

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLC 281
             V   LLE   + AS  AT   G T LH        + +N   + S    LL  GA   
Sbjct: 609 QKVALLLLE---KGASPHATAKNGYTPLHIA------AKKNQMQIAST---LLNYGAE-- 654

Query: 282 PTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
                 +I   Q +TPL LA++EG  ++   +L +
Sbjct: 655 -----TNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 39/167 (23%), Positives = 66/167 (39%), Gaps = 27/167 (16%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A ++ +   VKLL++ G  + A+                G  PL  AA +   
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRD-------------GLTPLHCAARSGHD 312

Query: 223 DVVSYLLE----------NPHQPASLQATDSQGNTVLHAL---VMISDNSAENI-ALVTS 268
            VV  LLE          N   P  + A       V H L     + D + + + AL  +
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372

Query: 269 MYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
            + G  +    L       + R L   TPL +A K+ +I++   +++
Sbjct: 373 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 419



 Score = 30.0 bits (66), Expect = 8.4
 Identities = 37/154 (24%), Positives = 61/154 (39%), Gaps = 32/154 (20%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G + LH+A ++     V LL++ GAN+H                  G   L LAA   +
Sbjct: 661 QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKS-------------GLTSLHLAAQEDK 707

Query: 222 WDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLC 281
            +V   L ++          D   +T L    +I      N+ +V    + LL+ GA + 
Sbjct: 708 VNVADILTKH--------GADQDAHTKLGYTPLIVACHYGNVKMV----NFLLKQGANV- 754

Query: 282 PTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
                 + +     TPL  AA++G   I   +LQ
Sbjct: 755 ------NAKTKNGYTPLHQAAQQGHTHIINVLLQ 782


>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
          Length = 1050

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 75/265 (28%), Positives = 106/265 (40%), Gaps = 51/265 (19%)

Query: 61  RKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCL 120
           R+G+ +++P  +    DRLF          L      LS+ +   TD  +   ++G    
Sbjct: 363 RQGSLSAKPPESEGFGDRLF----------LKQRMSLLSQMTSSPTDCLFKHIASGNQKE 412

Query: 121 MKAVLNL----KDGVNACILPLLQIDRD----SG--NPQPLVNAQCTDDYYRGHSALHIA 170
           ++ +L+     KD V     PL   D      SG  N   +V     DD  RGH+ LH+A
Sbjct: 413 VERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDD--RGHTPLHVA 470

Query: 171 IEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLE 230
                   + LLV  GA V+A               Y G  PL L AC K +  V+ LL 
Sbjct: 471 AVCGQASLIDLLVSKGAMVNATD-------------YHGATPLHL-ACQKGYQSVTLLL- 515

Query: 231 NPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIR 290
             H  AS +  D+ GNT LH   +      E+       YD       RL       DI 
Sbjct: 516 -LHYKASAEVQDNNGNTPLH---LACTYGHEDCVKALVYYD---VESCRL-------DIG 561

Query: 291 NLQDLTPLKLAAKEGKIEIFRHILQ 315
           N +  TPL +AA+ G   +   +LQ
Sbjct: 562 NEKGDTPLHIAARWGYQGVIETLLQ 586



 Score = 33.9 bits (76), Expect = 0.58
 Identities = 24/88 (27%), Positives = 43/88 (48%), Gaps = 16/88 (18%)

Query: 167 LHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVS 226
           LH+A ++   Q VK L+++ A  + +                G  PL  A      ++V+
Sbjct: 781 LHLACQQGHFQVVKCLLDSNAKPNKKDLS-------------GNTPLIYACSGGHHELVA 827

Query: 227 YLLENPHQPASLQATDSQGNTVLHALVM 254
            LL++    AS+ A++++GNT LH  V+
Sbjct: 828 LLLQHG---ASINASNNKGNTALHEAVI 852


>gi|209863028 transient receptor potential cation channel, subfamily
           C, member 4 isoform gamma [Homo sapiens]
          Length = 828

 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 71/293 (24%), Positives = 123/293 (41%), Gaps = 46/293 (15%)

Query: 386 LLIPKFFLNFLCN----LIYMFIFTAVAYH--QPTLKKQAAPHLKAEVGNSMLLTGHILI 439
           L I K F+ F+C+    L ++F+    + H  +  L +Q  P    E    M+L      
Sbjct: 357 LFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEW---MILPW---- 409

Query: 440 LLGGIYLLVGQLWYFWRR-HVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIE----- 493
           +LG I+  + Q+W    + ++  W + +D     L+L    L +V+ V  + A+      
Sbjct: 410 VLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATISLKIVAFVK-YSALNPRESW 468

Query: 494 --WYLPLLVSAL-----VLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFL 546
             W+  L+  AL     +   L L+       H G   + + +++L D+L+FL IY + L
Sbjct: 469 DMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLL-DILKFLFIYCLVL 527

Query: 547 FGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIG 606
             FA  L   +Q  +  E   G          +G   E     +  + E    LF    G
Sbjct: 528 LAFANGL---NQLYFYYEETKGLTC-------KGIRCEKQNNAFSTLFETLQSLFWSIFG 577

Query: 607 MGEL------AFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVA 653
           +  L      A  E   F G  +     Y +++ ++LLNMLIA+M+ +   +A
Sbjct: 578 LINLYVTNVKAQHEFTEFVGATMFG--TYNVISLVVLLNMLIAMMNNSYQLIA 628


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 45/147 (30%), Positives = 63/147 (42%), Gaps = 32/147 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A+   +L  VKLL+  G + H+ A             + G  PL +AA   Q 
Sbjct: 602 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-------------WNGYTPLHIAAKQNQV 648

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
           +V   LL+      S  A   QG T LH  +   +  AE +AL+ S      QA   L  
Sbjct: 649 EVARSLLQ---YGGSANAESVQGVTPLH--LAAQEGHAEMVALLLSK-----QANGNL-- 696

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEI 309
                   N   LTPL L A+EG + +
Sbjct: 697 -------GNKSGLTPLHLVAQEGHVPV 716



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 52/201 (25%), Positives = 79/201 (39%), Gaps = 43/201 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANV------------------HARACGRFFQKGQG- 203
           G + LHIA +K  ++ ++LL++ GA++                  H        Q+G   
Sbjct: 404 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 463

Query: 204 -TCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAEN 262
                  E PL +AA     +V  YLL+N    A + A      T LH    I       
Sbjct: 464 NVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGH----- 515

Query: 263 IALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLS 322
               T+M   LL+  A         ++      TPL +AA+EG +E    +L++E S   
Sbjct: 516 ----TNMVKLLLENNAN-------PNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 564

Query: 323 HLSRKFTEW----CYGPVRVS 339
              + FT       YG VRV+
Sbjct: 565 MTKKGFTPLHVAAKYGKVRVA 585



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 45/162 (27%), Positives = 68/162 (41%), Gaps = 38/162 (23%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G + LH+A +   ++  +LL+E  A  H  A G+            G  PL +A     
Sbjct: 568 KGFTPLHVAAKYGKVRVAELLLERDA--HPNAAGKN-----------GLTPLHVAVHHNN 614

Query: 222 WDVVSYLLE---NPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGA 278
            D+V  LL    +PH PA        G T LH  +    N  E +A     Y G   A  
Sbjct: 615 LDIVKLLLPRGGSPHSPAW------NGYTPLH--IAAKQNQVE-VARSLLQYGGSANA-- 663

Query: 279 RLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSG 320
                       ++Q +TPL LAA+EG  E+   +L ++ +G
Sbjct: 664 -----------ESVQGVTPLHLAAQEGHAEMVALLLSKQANG 694



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 43/165 (26%), Positives = 68/165 (41%), Gaps = 23/165 (13%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G++ALHIA      + V+ LV  GANV+A++     QK        G  PL +AA    
Sbjct: 110 KGNTALHIAALAGQDEVVRELVNYGANVNAQS-----QK--------GFTPLYMAAQENH 156

Query: 222 WDVVSYLLEN----------PHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYD 271
            +VV +LLEN             P ++       N V H +   +       AL  +  +
Sbjct: 157 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 216

Query: 272 GLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
              +  A L       D+ +    TPL +AA    + + + +L R
Sbjct: 217 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 261



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 44/175 (25%), Positives = 72/175 (41%), Gaps = 39/175 (22%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANV------------------HARACGRFFQKG--Q 202
           G S +H+A +   L CV+LL++  A +                  H R       KG   
Sbjct: 338 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 397

Query: 203 GTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAEN 262
            +    G  PL +A       V+  LL+     AS+ A    G T LH    +      +
Sbjct: 398 NSRALNGFTPLHIACKKNHVRVMELLLKT---GASIDAVTESGLTPLHVASFMG-----H 449

Query: 263 IALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQRE 317
           + +V +    LLQ GA         ++ N++  TPL +AA+ G  E+ +++LQ +
Sbjct: 450 LPIVKN----LLQRGAS-------PNVSNVKVETPLHMAARAGHTEVAKYLLQNK 493



 Score = 37.0 bits (84), Expect = 0.069
 Identities = 50/193 (25%), Positives = 77/193 (39%), Gaps = 39/193 (20%)

Query: 140 QIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRF-- 197
           ++ R+  N    VNAQ      +G + L++A ++  L+ VK L+ENGAN +      F  
Sbjct: 125 EVVRELVNYGANVNAQSQ----KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 180

Query: 198 ----FQKGQ----------GTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDS 243
                Q+G           GT        L +AA        + LL+N   P  L  T  
Sbjct: 181 LAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-- 238

Query: 244 QGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAK 303
            G T LH      + +   +         LL  GA +  T Q         +TPL +A++
Sbjct: 239 -GFTPLHIAAHYENLNVAQL---------LLNRGASVNFTPQ-------NGITPLHIASR 281

Query: 304 EGKIEIFRHILQR 316
            G + + R +L R
Sbjct: 282 RGNVIMVRLLLDR 294



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 26/87 (29%), Positives = 41/87 (47%), Gaps = 16/87 (18%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G++ LH+A    +++ VK L+++ A+V+A+                G  PL  AA     
Sbjct: 734 GYTPLHVASHYGNIKLVKFLLQHQADVNAKT-------------KLGYSPLHQAAQQGHT 780

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVL 249
           D+V+ LL+N    AS     S G T L
Sbjct: 781 DIVTLLLKN---GASPNEVSSDGTTPL 804



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 21/91 (23%), Positives = 42/91 (46%), Gaps = 16/91 (17%)

Query: 225 VSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTV 284
           V  ++E  H+   L+ T  +GNT LH   +   +          +   L+  GA +    
Sbjct: 91  VKMVVELLHKEIILETTTKKGNTALHIAALAGQD---------EVVRELVNYGANV---- 137

Query: 285 QLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
              + ++ +  TPL +AA+E  +E+ + +L+
Sbjct: 138 ---NAQSQKGFTPLYMAAQENHLEVVKFLLE 165


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 45/147 (30%), Positives = 63/147 (42%), Gaps = 32/147 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A+   +L  VKLL+  G + H+ A             + G  PL +AA   Q 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-------------WNGYTPLHIAAKQNQV 615

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
           +V   LL+      S  A   QG T LH  +   +  AE +AL+ S      QA   L  
Sbjct: 616 EVARSLLQ---YGGSANAESVQGVTPLH--LAAQEGHAEMVALLLSK-----QANGNL-- 663

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEI 309
                   N   LTPL L A+EG + +
Sbjct: 664 -------GNKSGLTPLHLVAQEGHVPV 683



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 52/201 (25%), Positives = 79/201 (39%), Gaps = 43/201 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANV------------------HARACGRFFQKGQG- 203
           G + LHIA +K  ++ ++LL++ GA++                  H        Q+G   
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 204 -TCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAEN 262
                  E PL +AA     +V  YLL+N    A + A      T LH    I       
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGH----- 482

Query: 263 IALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLS 322
               T+M   LL+  A         ++      TPL +AA+EG +E    +L++E S   
Sbjct: 483 ----TNMVKLLLENNAN-------PNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531

Query: 323 HLSRKFTEW----CYGPVRVS 339
              + FT       YG VRV+
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVA 552



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 45/162 (27%), Positives = 68/162 (41%), Gaps = 38/162 (23%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G + LH+A +   ++  +LL+E  A  H  A G+            G  PL +A     
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDA--HPNAAGKN-----------GLTPLHVAVHHNN 581

Query: 222 WDVVSYLLE---NPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGA 278
            D+V  LL    +PH PA        G T LH  +    N  E +A     Y G   A  
Sbjct: 582 LDIVKLLLPRGGSPHSPAW------NGYTPLH--IAAKQNQVE-VARSLLQYGGSANA-- 630

Query: 279 RLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSG 320
                       ++Q +TPL LAA+EG  E+   +L ++ +G
Sbjct: 631 -----------ESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 43/165 (26%), Positives = 68/165 (41%), Gaps = 23/165 (13%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G++ALHIA      + V+ LV  GANV+A++     QK        G  PL +AA    
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQS-----QK--------GFTPLYMAAQENH 123

Query: 222 WDVVSYLLEN----------PHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYD 271
            +VV +LLEN             P ++       N V H +   +       AL  +  +
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 272 GLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
              +  A L       D+ +    TPL +AA    + + + +L R
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 44/175 (25%), Positives = 72/175 (41%), Gaps = 39/175 (22%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANV------------------HARACGRFFQKG--Q 202
           G S +H+A +   L CV+LL++  A +                  H R       KG   
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 203 GTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAEN 262
            +    G  PL +A       V+  LL+     AS+ A    G T LH    +      +
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKT---GASIDAVTESGLTPLHVASFMG-----H 416

Query: 263 IALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQRE 317
           + +V +    LLQ GA         ++ N++  TPL +AA+ G  E+ +++LQ +
Sbjct: 417 LPIVKN----LLQRGAS-------PNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460



 Score = 37.0 bits (84), Expect = 0.069
 Identities = 50/193 (25%), Positives = 77/193 (39%), Gaps = 39/193 (20%)

Query: 140 QIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRF-- 197
           ++ R+  N    VNAQ      +G + L++A ++  L+ VK L+ENGAN +      F  
Sbjct: 92  EVVRELVNYGANVNAQSQ----KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 198 ----FQKGQ----------GTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDS 243
                Q+G           GT        L +AA        + LL+N   P  L  T  
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-- 205

Query: 244 QGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAK 303
            G T LH      + +   +         LL  GA +  T Q         +TPL +A++
Sbjct: 206 -GFTPLHIAAHYENLNVAQL---------LLNRGASVNFTPQ-------NGITPLHIASR 248

Query: 304 EGKIEIFRHILQR 316
            G + + R +L R
Sbjct: 249 RGNVIMVRLLLDR 261



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 26/87 (29%), Positives = 41/87 (47%), Gaps = 16/87 (18%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G++ LH+A    +++ VK L+++ A+V+A+                G  PL  AA     
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKT-------------KLGYSPLHQAAQQGHT 747

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVL 249
           D+V+ LL+N    AS     S G T L
Sbjct: 748 DIVTLLLKN---GASPNEVSSDGTTPL 771



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 21/91 (23%), Positives = 42/91 (46%), Gaps = 16/91 (17%)

Query: 225 VSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTV 284
           V  ++E  H+   L+ T  +GNT LH   +   +          +   L+  GA +    
Sbjct: 58  VKMVVELLHKEIILETTTKKGNTALHIAALAGQD---------EVVRELVNYGANV---- 104

Query: 285 QLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
              + ++ +  TPL +AA+E  +E+ + +L+
Sbjct: 105 ---NAQSQKGFTPLYMAAQENHLEVVKFLLE 132


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 45/147 (30%), Positives = 63/147 (42%), Gaps = 32/147 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A+   +L  VKLL+  G + H+ A             + G  PL +AA   Q 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-------------WNGYTPLHIAAKQNQV 615

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
           +V   LL+      S  A   QG T LH  +   +  AE +AL+ S      QA   L  
Sbjct: 616 EVARSLLQ---YGGSANAESVQGVTPLH--LAAQEGHAEMVALLLSK-----QANGNL-- 663

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEI 309
                   N   LTPL L A+EG + +
Sbjct: 664 -------GNKSGLTPLHLVAQEGHVPV 683



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 52/201 (25%), Positives = 79/201 (39%), Gaps = 43/201 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANV------------------HARACGRFFQKGQG- 203
           G + LHIA +K  ++ ++LL++ GA++                  H        Q+G   
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 204 -TCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAEN 262
                  E PL +AA     +V  YLL+N    A + A      T LH    I       
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGH----- 482

Query: 263 IALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLS 322
               T+M   LL+  A         ++      TPL +AA+EG +E    +L++E S   
Sbjct: 483 ----TNMVKLLLENNAN-------PNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531

Query: 323 HLSRKFTEW----CYGPVRVS 339
              + FT       YG VRV+
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVA 552



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 45/162 (27%), Positives = 68/162 (41%), Gaps = 38/162 (23%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G + LH+A +   ++  +LL+E  A  H  A G+            G  PL +A     
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDA--HPNAAGKN-----------GLTPLHVAVHHNN 581

Query: 222 WDVVSYLLE---NPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGA 278
            D+V  LL    +PH PA        G T LH  +    N  E +A     Y G   A  
Sbjct: 582 LDIVKLLLPRGGSPHSPAW------NGYTPLH--IAAKQNQVE-VARSLLQYGGSANA-- 630

Query: 279 RLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSG 320
                       ++Q +TPL LAA+EG  E+   +L ++ +G
Sbjct: 631 -----------ESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 43/165 (26%), Positives = 68/165 (41%), Gaps = 23/165 (13%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G++ALHIA      + V+ LV  GANV+A++     QK        G  PL +AA    
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQS-----QK--------GFTPLYMAAQENH 123

Query: 222 WDVVSYLLEN----------PHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYD 271
            +VV +LLEN             P ++       N V H +   +       AL  +  +
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 272 GLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
              +  A L       D+ +    TPL +AA    + + + +L R
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 44/175 (25%), Positives = 72/175 (41%), Gaps = 39/175 (22%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANV------------------HARACGRFFQKG--Q 202
           G S +H+A +   L CV+LL++  A +                  H R       KG   
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 203 GTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAEN 262
            +    G  PL +A       V+  LL+     AS+ A    G T LH    +      +
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKT---GASIDAVTESGLTPLHVASFMG-----H 416

Query: 263 IALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQRE 317
           + +V +    LLQ GA         ++ N++  TPL +AA+ G  E+ +++LQ +
Sbjct: 417 LPIVKN----LLQRGAS-------PNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460



 Score = 37.0 bits (84), Expect = 0.069
 Identities = 50/193 (25%), Positives = 77/193 (39%), Gaps = 39/193 (20%)

Query: 140 QIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRF-- 197
           ++ R+  N    VNAQ      +G + L++A ++  L+ VK L+ENGAN +      F  
Sbjct: 92  EVVRELVNYGANVNAQSQ----KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 198 ----FQKGQ----------GTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDS 243
                Q+G           GT        L +AA        + LL+N   P  L  T  
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-- 205

Query: 244 QGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAK 303
            G T LH      + +   +         LL  GA +  T Q         +TPL +A++
Sbjct: 206 -GFTPLHIAAHYENLNVAQL---------LLNRGASVNFTPQ-------NGITPLHIASR 248

Query: 304 EGKIEIFRHILQR 316
            G + + R +L R
Sbjct: 249 RGNVIMVRLLLDR 261



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 26/87 (29%), Positives = 41/87 (47%), Gaps = 16/87 (18%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G++ LH+A    +++ VK L+++ A+V+A+                G  PL  AA     
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKT-------------KLGYSPLHQAAQQGHT 747

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVL 249
           D+V+ LL+N    AS     S G T L
Sbjct: 748 DIVTLLLKN---GASPNEVSSDGTTPL 771



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 21/91 (23%), Positives = 42/91 (46%), Gaps = 16/91 (17%)

Query: 225 VSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTV 284
           V  ++E  H+   L+ T  +GNT LH   +   +          +   L+  GA +    
Sbjct: 58  VKMVVELLHKEIILETTTKKGNTALHIAALAGQD---------EVVRELVNYGANV---- 104

Query: 285 QLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
              + ++ +  TPL +AA+E  +E+ + +L+
Sbjct: 105 ---NAQSQKGFTPLYMAAQENHLEVVKFLLE 132


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 45/147 (30%), Positives = 63/147 (42%), Gaps = 32/147 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A+   +L  VKLL+  G + H+ A             + G  PL +AA   Q 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-------------WNGYTPLHIAAKQNQV 615

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
           +V   LL+      S  A   QG T LH  +   +  AE +AL+ S      QA   L  
Sbjct: 616 EVARSLLQ---YGGSANAESVQGVTPLH--LAAQEGHAEMVALLLSK-----QANGNL-- 663

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEI 309
                   N   LTPL L A+EG + +
Sbjct: 664 -------GNKSGLTPLHLVAQEGHVPV 683



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 52/201 (25%), Positives = 79/201 (39%), Gaps = 43/201 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANV------------------HARACGRFFQKGQG- 203
           G + LHIA +K  ++ ++LL++ GA++                  H        Q+G   
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 204 -TCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAEN 262
                  E PL +AA     +V  YLL+N    A + A      T LH    I       
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGH----- 482

Query: 263 IALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLS 322
               T+M   LL+  A         ++      TPL +AA+EG +E    +L++E S   
Sbjct: 483 ----TNMVKLLLENNAN-------PNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531

Query: 323 HLSRKFTEW----CYGPVRVS 339
              + FT       YG VRV+
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVA 552



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 45/162 (27%), Positives = 68/162 (41%), Gaps = 38/162 (23%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G + LH+A +   ++  +LL+E  A  H  A G+            G  PL +A     
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDA--HPNAAGKN-----------GLTPLHVAVHHNN 581

Query: 222 WDVVSYLLE---NPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGA 278
            D+V  LL    +PH PA        G T LH  +    N  E +A     Y G   A  
Sbjct: 582 LDIVKLLLPRGGSPHSPAW------NGYTPLH--IAAKQNQVE-VARSLLQYGGSANA-- 630

Query: 279 RLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSG 320
                       ++Q +TPL LAA+EG  E+   +L ++ +G
Sbjct: 631 -----------ESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 43/165 (26%), Positives = 68/165 (41%), Gaps = 23/165 (13%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G++ALHIA      + V+ LV  GANV+A++     QK        G  PL +AA    
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQS-----QK--------GFTPLYMAAQENH 123

Query: 222 WDVVSYLLEN----------PHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYD 271
            +VV +LLEN             P ++       N V H +   +       AL  +  +
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 272 GLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
              +  A L       D+ +    TPL +AA    + + + +L R
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 44/175 (25%), Positives = 72/175 (41%), Gaps = 39/175 (22%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANV------------------HARACGRFFQKG--Q 202
           G S +H+A +   L CV+LL++  A +                  H R       KG   
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 203 GTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAEN 262
            +    G  PL +A       V+  LL+     AS+ A    G T LH    +      +
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKT---GASIDAVTESGLTPLHVASFMG-----H 416

Query: 263 IALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQRE 317
           + +V +    LLQ GA         ++ N++  TPL +AA+ G  E+ +++LQ +
Sbjct: 417 LPIVKN----LLQRGAS-------PNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460



 Score = 37.0 bits (84), Expect = 0.069
 Identities = 50/193 (25%), Positives = 77/193 (39%), Gaps = 39/193 (20%)

Query: 140 QIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRF-- 197
           ++ R+  N    VNAQ      +G + L++A ++  L+ VK L+ENGAN +      F  
Sbjct: 92  EVVRELVNYGANVNAQSQ----KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 198 ----FQKGQ----------GTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDS 243
                Q+G           GT        L +AA        + LL+N   P  L  T  
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-- 205

Query: 244 QGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAK 303
            G T LH      + +   +         LL  GA +  T Q         +TPL +A++
Sbjct: 206 -GFTPLHIAAHYENLNVAQL---------LLNRGASVNFTPQ-------NGITPLHIASR 248

Query: 304 EGKIEIFRHILQR 316
            G + + R +L R
Sbjct: 249 RGNVIMVRLLLDR 261



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 26/87 (29%), Positives = 41/87 (47%), Gaps = 16/87 (18%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G++ LH+A    +++ VK L+++ A+V+A+                G  PL  AA     
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKT-------------KLGYSPLHQAAQQGHT 747

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVL 249
           D+V+ LL+N    AS     S G T L
Sbjct: 748 DIVTLLLKN---GASPNEVSSDGTTPL 771



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 21/91 (23%), Positives = 42/91 (46%), Gaps = 16/91 (17%)

Query: 225 VSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTV 284
           V  ++E  H+   L+ T  +GNT LH   +   +          +   L+  GA +    
Sbjct: 58  VKMVVELLHKEIILETTTKKGNTALHIAALAGQD---------EVVRELVNYGANV---- 104

Query: 285 QLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
              + ++ +  TPL +AA+E  +E+ + +L+
Sbjct: 105 ---NAQSQKGFTPLYMAAQENHLEVVKFLLE 132


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 45/147 (30%), Positives = 63/147 (42%), Gaps = 32/147 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G + LH+A+   +L  VKLL+  G + H+ A             + G  PL +AA   Q 
Sbjct: 569 GLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA-------------WNGYTPLHIAAKQNQV 615

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCP 282
           +V   LL+      S  A   QG T LH  +   +  AE +AL+ S      QA   L  
Sbjct: 616 EVARSLLQ---YGGSANAESVQGVTPLH--LAAQEGHAEMVALLLSK-----QANGNL-- 663

Query: 283 TVQLEDIRNLQDLTPLKLAAKEGKIEI 309
                   N   LTPL L A+EG + +
Sbjct: 664 -------GNKSGLTPLHLVAQEGHVPV 683



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 52/201 (25%), Positives = 79/201 (39%), Gaps = 43/201 (21%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANV------------------HARACGRFFQKGQG- 203
           G + LHIA +K  ++ ++LL++ GA++                  H        Q+G   
Sbjct: 371 GFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASP 430

Query: 204 -TCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAEN 262
                  E PL +AA     +V  YLL+N    A + A      T LH    I       
Sbjct: 431 NVSNVKVETPLHMAARAGHTEVAKYLLQNK---AKVNAKAKDDQTPLHCAARIGH----- 482

Query: 263 IALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLS 322
               T+M   LL+  A         ++      TPL +AA+EG +E    +L++E S   
Sbjct: 483 ----TNMVKLLLENNAN-------PNLATTAGHTPLHIAAREGHVETVLALLEKEASQAC 531

Query: 323 HLSRKFTEW----CYGPVRVS 339
              + FT       YG VRV+
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVA 552



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 45/162 (27%), Positives = 68/162 (41%), Gaps = 38/162 (23%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G + LH+A +   ++  +LL+E  A  H  A G+            G  PL +A     
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDA--HPNAAGKN-----------GLTPLHVAVHHNN 581

Query: 222 WDVVSYLLE---NPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGA 278
            D+V  LL    +PH PA        G T LH  +    N  E +A     Y G   A  
Sbjct: 582 LDIVKLLLPRGGSPHSPAW------NGYTPLH--IAAKQNQVE-VARSLLQYGGSANA-- 630

Query: 279 RLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSG 320
                       ++Q +TPL LAA+EG  E+   +L ++ +G
Sbjct: 631 -----------ESVQGVTPLHLAAQEGHAEMVALLLSKQANG 661



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 43/165 (26%), Positives = 68/165 (41%), Gaps = 23/165 (13%)

Query: 162 RGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQ 221
           +G++ALHIA      + V+ LV  GANV+A++     QK        G  PL +AA    
Sbjct: 77  KGNTALHIAALAGQDEVVRELVNYGANVNAQS-----QK--------GFTPLYMAAQENH 123

Query: 222 WDVVSYLLEN----------PHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYD 271
            +VV +LLEN             P ++       N V H +   +       AL  +  +
Sbjct: 124 LEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARN 183

Query: 272 GLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQR 316
              +  A L       D+ +    TPL +AA    + + + +L R
Sbjct: 184 DDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNR 228



 Score = 38.5 bits (88), Expect = 0.024
 Identities = 44/175 (25%), Positives = 72/175 (41%), Gaps = 39/175 (22%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANV------------------HARACGRFFQKG--Q 202
           G S +H+A +   L CV+LL++  A +                  H R       KG   
Sbjct: 305 GLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKP 364

Query: 203 GTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAEN 262
            +    G  PL +A       V+  LL+     AS+ A    G T LH    +      +
Sbjct: 365 NSRALNGFTPLHIACKKNHVRVMELLLKT---GASIDAVTESGLTPLHVASFMG-----H 416

Query: 263 IALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQRE 317
           + +V +    LLQ GA         ++ N++  TPL +AA+ G  E+ +++LQ +
Sbjct: 417 LPIVKN----LLQRGAS-------PNVSNVKVETPLHMAARAGHTEVAKYLLQNK 460



 Score = 37.0 bits (84), Expect = 0.069
 Identities = 50/193 (25%), Positives = 77/193 (39%), Gaps = 39/193 (20%)

Query: 140 QIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRF-- 197
           ++ R+  N    VNAQ      +G + L++A ++  L+ VK L+ENGAN +      F  
Sbjct: 92  EVVRELVNYGANVNAQSQ----KGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTP 147

Query: 198 ----FQKGQ----------GTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDS 243
                Q+G           GT        L +AA        + LL+N   P  L  T  
Sbjct: 148 LAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKT-- 205

Query: 244 QGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAK 303
            G T LH      + +   +         LL  GA +  T Q         +TPL +A++
Sbjct: 206 -GFTPLHIAAHYENLNVAQL---------LLNRGASVNFTPQ-------NGITPLHIASR 248

Query: 304 EGKIEIFRHILQR 316
            G + + R +L R
Sbjct: 249 RGNVIMVRLLLDR 261



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 26/87 (29%), Positives = 41/87 (47%), Gaps = 16/87 (18%)

Query: 163 GHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQW 222
           G++ LH+A    +++ VK L+++ A+V+A+                G  PL  AA     
Sbjct: 701 GYTPLHVASHYGNIKLVKFLLQHQADVNAKT-------------KLGYSPLHQAAQQGHT 747

Query: 223 DVVSYLLENPHQPASLQATDSQGNTVL 249
           D+V+ LL+N    AS     S G T L
Sbjct: 748 DIVTLLLKN---GASPNEVSSDGTTPL 771



 Score = 30.8 bits (68), Expect = 4.9
 Identities = 21/91 (23%), Positives = 42/91 (46%), Gaps = 16/91 (17%)

Query: 225 VSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTV 284
           V  ++E  H+   L+ T  +GNT LH   +   +          +   L+  GA +    
Sbjct: 58  VKMVVELLHKEIILETTTKKGNTALHIAALAGQD---------EVVRELVNYGANV---- 104

Query: 285 QLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
              + ++ +  TPL +AA+E  +E+ + +L+
Sbjct: 105 ---NAQSQKGFTPLYMAAQENHLEVVKFLLE 132


>gi|20270347 ankyrin repeat domain 54 [Homo sapiens]
          Length = 300

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 44/139 (31%), Positives = 63/139 (45%), Gaps = 27/139 (19%)

Query: 113 GSTGKTCLMKAVLNLKDGVNAC-ILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAI 171
           G TGK   + A+  L+D  NA  +  + Q+  D  +P       C  D  +G +ALH A 
Sbjct: 102 GPTGKE--VHALKRLRDSANANDVETVQQLLEDGADP-------CAADD-KGRTALHFAS 151

Query: 172 EKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLEN 231
              + Q V+LL+++GA+ + R                G  PL LAACT    V++ LL  
Sbjct: 152 CNGNDQIVQLLLDHGADPNQRD-------------GLGNTPLHLAACTNHVPVITTLLRG 198

Query: 232 PHQPASLQATDSQGNTVLH 250
               A + A D  G T LH
Sbjct: 199 ---GARVDALDRAGRTPLH 214


>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
          Length = 1119

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 42/158 (26%), Positives = 67/158 (42%), Gaps = 33/158 (20%)

Query: 158 DDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAA 217
           DDY  G++ LH A+EK  ++ VK L+  GAN + R                   PL +A 
Sbjct: 95  DDY--GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMM-------------APLHIAV 139

Query: 218 CTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAG 277
                +V+  LLE  H+   +      GNT +  ++  + N++E + +       LL+ G
Sbjct: 140 QGMNNEVMKVLLE--HRTIDVNLEGENGNTAV--IIACTTNNSEALQI-------LLKKG 188

Query: 278 ARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
           A+ C +       N     P+  AA  G  E    IL+
Sbjct: 189 AKPCKS-------NKWGCFPIHQAAFSGSKECMEIILR 219



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 40/169 (23%), Positives = 78/169 (46%), Gaps = 23/169 (13%)

Query: 399 LIYMFIFTAVAYHQPTLKKQAAPHLKA-EVGNSMLL-TGHILILLGGIYLL---VGQLWY 453
           ++ + I   +A++   +  + + H +  +  NS L+ T  IL+ L  I+      GQ++ 
Sbjct: 735 ILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQ 794

Query: 454 FWRRH------VFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGW 507
             R +      V  WI +      +L LF  +   +      +A+ +Y           W
Sbjct: 795 QKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFY-----------W 843

Query: 508 LNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSL 556
           +N L Y + F++ GI+ VM++ VIL+ LLR  ++++  L  F ++   L
Sbjct: 844 MNFLLYLQRFENCGIFIVMLE-VILKTLLRSTVVFIFLLLAFGLSFYIL 891


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score = 42.4 bits (98), Expect = 0.002
 Identities = 44/172 (25%), Positives = 77/172 (44%), Gaps = 33/172 (19%)

Query: 161  YRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTK 220
            Y G +AL +A  +     V+LL  +GA+V+ +                G   L + A   
Sbjct: 911  YDGRNALRVAALEGHRDIVELLFSHGADVNCKDAD-------------GRPTLYILALEN 957

Query: 221  QWDVVSYLLENPHQPASLQATDSQGNTVLHA--------LVMI------SDNSAEN---I 263
            Q  +  Y LEN    A+++A+D++G T LH         +V +        N+A+N    
Sbjct: 958  QLTMAEYFLEN---GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRS 1014

Query: 264  ALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQ 315
            AL ++ + G ++    L     + D    Q  T L +AA+EG I++ + +L+
Sbjct: 1015 ALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLE 1066


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,801,492
Number of Sequences: 37866
Number of extensions: 1379057
Number of successful extensions: 4552
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 3870
Number of HSP's gapped (non-prelim): 555
length of query: 764
length of database: 18,247,518
effective HSP length: 110
effective length of query: 654
effective length of database: 14,082,258
effective search space: 9209796732
effective search space used: 9209796732
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.