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Search of human proteins with 19923424
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19923424 myotubularin related protein 9 [Homo sapiens]
(549 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19923424 myotubularin related protein 9 [Homo sapiens] 1125 0.0
gi|225543474 myotubularin related protein 7 [Homo sapiens] 342 5e-94
gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens] 333 2e-91
gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens] 333 2e-91
gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens] 333 2e-91
gi|134142348 myotubularin related protein 6 [Homo sapiens] 324 1e-88
gi|28872761 myotubularin-related protein 1 [Homo sapiens] 324 1e-88
gi|21361759 myotubularin related protein 8 [Homo sapiens] 320 3e-87
gi|4557896 myotubularin [Homo sapiens] 297 1e-80
gi|217272865 myotubularin related protein 4 [Homo sapiens] 251 2e-66
gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens] 240 2e-63
gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens] 240 2e-63
gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens] 240 2e-63
gi|124028527 myotubularin related protein 10 [Homo sapiens] 159 5e-39
gi|224994251 myotubularin related protein 11 isoform a [Homo sap... 150 4e-36
gi|89111941 myotubularin related protein 11 isoform b [Homo sapi... 150 4e-36
gi|94721263 myotubularin related protein 12 [Homo sapiens] 127 3e-29
gi|29788755 SET binding factor 2 [Homo sapiens] 121 2e-27
gi|239735519 SET binding factor 1 [Homo sapiens] 118 2e-26
gi|54112397 calcium channel, voltage-dependent, alpha 2/delta 3 ... 30 5.7
gi|122937311 solute carrier family 35, member F4 [Homo sapiens] 30 5.7
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 30 7.5
>gi|19923424 myotubularin related protein 9 [Homo sapiens]
Length = 549
Score = 1125 bits (2909), Expect = 0.0
Identities = 549/549 (100%), Positives = 549/549 (100%)
Query: 1 MEFAELIKTPRVDNVVLHRPFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDK 60
MEFAELIKTPRVDNVVLHRPFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDK
Sbjct: 1 MEFAELIKTPRVDNVVLHRPFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDK 60
Query: 61 RFVGSLGTIIIKCKDFRIIQLDIPGMEECLNIASSIEALSTLDSITLMYPFFYRPMFEVI 120
RFVGSLGTIIIKCKDFRIIQLDIPGMEECLNIASSIEALSTLDSITLMYPFFYRPMFEVI
Sbjct: 61 RFVGSLGTIIIKCKDFRIIQLDIPGMEECLNIASSIEALSTLDSITLMYPFFYRPMFEVI 120
Query: 121 EDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFR 180
EDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFR
Sbjct: 121 EDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFR 180
Query: 181 HGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRGYIIDTRSLN 240
HGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRGYIIDTRSLN
Sbjct: 181 HGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRGYIIDTRSLN 240
Query: 241 VAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLE 300
VAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLE
Sbjct: 241 VAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLE 300
Query: 301 ASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRG 360
ASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRG
Sbjct: 301 ASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRG 360
Query: 361 FEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNEN 420
FEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNEN
Sbjct: 361 FEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNEN 420
Query: 421 FLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEANNL 480
FLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEANNL
Sbjct: 421 FLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEANNL 480
Query: 481 VIWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQAKVNILRRQLAELE 540
VIWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQAKVNILRRQLAELE
Sbjct: 481 VIWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQAKVNILRRQLAELE 540
Query: 541 TEDGMQESP 549
TEDGMQESP
Sbjct: 541 TEDGMQESP 549
>gi|225543474 myotubularin related protein 7 [Homo sapiens]
Length = 660
Score = 342 bits (877), Expect = 5e-94
Identities = 200/553 (36%), Positives = 311/553 (56%), Gaps = 25/553 (4%)
Query: 5 ELIKTPRVDNVVLHRPFYP--AVEGTLCLTGHHLI-LSSRQDNTEELWLLHSNIDAIDKR 61
E I+TP+V+NV L P A GTL LT H+I + + D +E W+LHS I I+K+
Sbjct: 2 EHIRTPKVENVRLVDRVSPKKAALGTLYLTATHVIFVENSPDPRKETWILHSQISTIEKQ 61
Query: 62 FVGSLGT-IIIKCKDFRIIQLDIPGMEECLNIASSIEALSTLDSITLMYPFFYRPMF--E 118
+ G ++I+CK+F+IIQL IP +C ++ S+ L+ +Y F + PM E
Sbjct: 62 ATTATGCPLLIRCKNFQIIQLIIPQERDCHDVYISLIRLARPVKYEELYCFSFNPMLDKE 121
Query: 119 VIEDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVAT 178
E GW +E+ W+LS VN+++ VC SYP + VPKS + +
Sbjct: 122 EREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSK 181
Query: 179 FRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRG---YIID 235
FR RFPVLSYY+K N I RS QPL+G + R C EDE+++ A +A Y++D
Sbjct: 182 FRSRRRFPVLSYYYKDNHASICRSSQPLSGFSAR-CLEDEQMLQAIRKANPGSDFVYVVD 240
Query: 236 TRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRW 295
TR A RA G G+E E +Y + IE H+++ SL K++E C ++ +M +
Sbjct: 241 TRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDF 300
Query: 296 LSKLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRS 355
L LE S WL HIK I+ A+ + EGAS+L+H ++G D T QV S+A ++L+P
Sbjct: 301 LWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHY 360
Query: 356 RTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSF 415
RT++GF LIE++W+ GH F R + K +PV F++CVWQ++ QFPC+F
Sbjct: 361 RTLKGFMVLIEKDWISFGHKFNHRYGN---LDGDPKEISPVIDQFIECVWQLMEQFPCAF 417
Query: 416 EFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWS--WVNQPSELSKFTNP 473
EFNE FLI + H Y+ QFG FL N++ ER +LK+Q++T SLW+ W N+ + + NP
Sbjct: 418 EFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNR----ADYLNP 473
Query: 474 LFEANNLVIWPSVAPQSLP------LWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQA 527
LF A++ ++ + P W G++ R+ + + + ++ + E ++L+
Sbjct: 474 LFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAVKEETQQLEE 533
Query: 528 KVNILRRQLAELE 540
++ L +L +++
Sbjct: 534 ELEALEERLEKIQ 546
>gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens]
Length = 643
Score = 333 bits (855), Expect = 2e-91
Identities = 199/547 (36%), Positives = 305/547 (55%), Gaps = 30/547 (5%)
Query: 20 PFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDK---------RFVGSLGTII 70
PF AV GTL +T + L S + + ++L +++ I++ R S G
Sbjct: 96 PFTGAVRGTLTVTNYRLYFKSMERDPP--FVLDASLGVINRVEKIGGASSRGENSYGLET 153
Query: 71 IKCKDFRIIQL-DIPGMEECLNIASSIEALSTLDSITL-MYPFFYRPMFEVIEDGWHSFL 128
+ CKD R ++ P +I ++ + S L ++ F Y+ +F E+GW +
Sbjct: 154 V-CKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFP--ENGWKLYD 210
Query: 129 PEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVL 188
P E+ WR++ +N+ + +C +YP ++ VP +I DE L++VA+FR GR PVL
Sbjct: 211 PLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVL 270
Query: 189 SYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRG---YIIDTRSLNVAQQT 245
S+ H ++ I R QP+ G +G+R KEDEK + A + + + +I D R A
Sbjct: 271 SWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVAN 330
Query: 246 RAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACN---DQTHNMDRWLSKLEAS 302
+AKGGG+E E Y + I H+++ESL KL E ++TH WLS LE++
Sbjct: 331 KAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETH----WLSNLEST 386
Query: 303 NWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFE 362
+WL HIK IL A A ++ S+++H ++G D T Q+TSLA ++L+ RTIRGFE
Sbjct: 387 HWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFE 446
Query: 363 ALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFL 422
L+E+EWL GH FQ R N +PVFL F+DCVWQ+ RQFP +FEFNE FL
Sbjct: 447 VLVEKEWLSFGHRFQLRVGHGDK-NHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFL 505
Query: 423 IMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEA-NNLV 481
I + +H Y+ FGTFL N+E +R K L ++T+SLWS++N S+L FTNPL+ + +N V
Sbjct: 506 ITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYIN--SQLEDFTNPLYGSYSNHV 563
Query: 482 IWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQAKVNILRRQLAELET 541
++P + + L LW G ++RWN K + + ++ ELQ KV L+R+++ T
Sbjct: 564 LYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAELQKKVEELQREISNRST 623
Query: 542 EDGMQES 548
+ S
Sbjct: 624 SSSERAS 630
>gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens]
Length = 571
Score = 333 bits (855), Expect = 2e-91
Identities = 199/547 (36%), Positives = 305/547 (55%), Gaps = 30/547 (5%)
Query: 20 PFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDK---------RFVGSLGTII 70
PF AV GTL +T + L S + + ++L +++ I++ R S G
Sbjct: 24 PFTGAVRGTLTVTNYRLYFKSMERDPP--FVLDASLGVINRVEKIGGASSRGENSYGLET 81
Query: 71 IKCKDFRIIQL-DIPGMEECLNIASSIEALSTLDSITL-MYPFFYRPMFEVIEDGWHSFL 128
+ CKD R ++ P +I ++ + S L ++ F Y+ +F E+GW +
Sbjct: 82 V-CKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFP--ENGWKLYD 138
Query: 129 PEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVL 188
P E+ WR++ +N+ + +C +YP ++ VP +I DE L++VA+FR GR PVL
Sbjct: 139 PLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVL 198
Query: 189 SYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRG---YIIDTRSLNVAQQT 245
S+ H ++ I R QP+ G +G+R KEDEK + A + + + +I D R A
Sbjct: 199 SWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVAN 258
Query: 246 RAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACN---DQTHNMDRWLSKLEAS 302
+AKGGG+E E Y + I H+++ESL KL E ++TH WLS LE++
Sbjct: 259 KAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETH----WLSNLEST 314
Query: 303 NWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFE 362
+WL HIK IL A A ++ S+++H ++G D T Q+TSLA ++L+ RTIRGFE
Sbjct: 315 HWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFE 374
Query: 363 ALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFL 422
L+E+EWL GH FQ R N +PVFL F+DCVWQ+ RQFP +FEFNE FL
Sbjct: 375 VLVEKEWLSFGHRFQLRVGHGDK-NHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFL 433
Query: 423 IMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEA-NNLV 481
I + +H Y+ FGTFL N+E +R K L ++T+SLWS++N S+L FTNPL+ + +N V
Sbjct: 434 ITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYIN--SQLEDFTNPLYGSYSNHV 491
Query: 482 IWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQAKVNILRRQLAELET 541
++P + + L LW G ++RWN K + + ++ ELQ KV L+R+++ T
Sbjct: 492 LYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAELQKKVEELQREISNRST 551
Query: 542 EDGMQES 548
+ S
Sbjct: 552 SSSERAS 558
>gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens]
Length = 571
Score = 333 bits (855), Expect = 2e-91
Identities = 199/547 (36%), Positives = 305/547 (55%), Gaps = 30/547 (5%)
Query: 20 PFYPAVEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDK---------RFVGSLGTII 70
PF AV GTL +T + L S + + ++L +++ I++ R S G
Sbjct: 24 PFTGAVRGTLTVTNYRLYFKSMERDPP--FVLDASLGVINRVEKIGGASSRGENSYGLET 81
Query: 71 IKCKDFRIIQL-DIPGMEECLNIASSIEALSTLDSITL-MYPFFYRPMFEVIEDGWHSFL 128
+ CKD R ++ P +I ++ + S L ++ F Y+ +F E+GW +
Sbjct: 82 V-CKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFP--ENGWKLYD 138
Query: 129 PEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVL 188
P E+ WR++ +N+ + +C +YP ++ VP +I DE L++VA+FR GR PVL
Sbjct: 139 PLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVL 198
Query: 189 SYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRG---YIIDTRSLNVAQQT 245
S+ H ++ I R QP+ G +G+R KEDEK + A + + + +I D R A
Sbjct: 199 SWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVAN 258
Query: 246 RAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACN---DQTHNMDRWLSKLEAS 302
+AKGGG+E E Y + I H+++ESL KL E ++TH WLS LE++
Sbjct: 259 KAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETH----WLSNLEST 314
Query: 303 NWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFE 362
+WL HIK IL A A ++ S+++H ++G D T Q+TSLA ++L+ RTIRGFE
Sbjct: 315 HWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFE 374
Query: 363 ALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFL 422
L+E+EWL GH FQ R N +PVFL F+DCVWQ+ RQFP +FEFNE FL
Sbjct: 375 VLVEKEWLSFGHRFQLRVGHGDK-NHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFL 433
Query: 423 IMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEA-NNLV 481
I + +H Y+ FGTFL N+E +R K L ++T+SLWS++N S+L FTNPL+ + +N V
Sbjct: 434 ITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYIN--SQLEDFTNPLYGSYSNHV 491
Query: 482 IWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQAKVNILRRQLAELET 541
++P + + L LW G ++RWN K + + ++ ELQ KV L+R+++ T
Sbjct: 492 LYPVASMRHLELWVGYYIRWNPRMKPQEPIHNRYKELLAKRAELQKKVEELQREISNRST 551
Query: 542 EDGMQES 548
+ S
Sbjct: 552 SSSERAS 558
>gi|134142348 myotubularin related protein 6 [Homo sapiens]
Length = 621
Score = 324 bits (831), Expect = 1e-88
Identities = 188/546 (34%), Positives = 303/546 (55%), Gaps = 20/546 (3%)
Query: 5 ELIKTPRVDNVVLHRPFYPA---VEGTLCLTGHHLILSSRQDNTEELWLLHSNIDAIDKR 61
E I+T +V+ V L F + + GTL LT HL+ + +E W+LH +I +++K
Sbjct: 2 EHIRTTKVEQVKLLDRFSTSNKSLTGTLYLTATHLLFID--SHQKETWILHHHIASVEKL 59
Query: 62 FVGSLGT-IIIKCKDFRIIQLDIPGMEECLNIASSIEALSTLDSITLMYPFFYRPMFEVI 120
+ + G ++I+CK+FR + +P +C +I +S+ LS +Y F Y P
Sbjct: 60 ALTTSGCPLVIQCKNFRTVHFIVPRERDCHDIYNSLLQLSKQAKYEDLYAFSYNPKQNDS 119
Query: 121 E--DGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVAT 178
E GW +E++ S W+LS N+++ +C +YP + VP+ + +
Sbjct: 120 ERLQGWQLIDLAEEYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSK 179
Query: 179 FRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAG---KRGYIID 235
FR GRFPVLSYYH+ I R QPL+G + R C EDE L+ A +A + Y++D
Sbjct: 180 FRSKGRFPVLSYYHQDKEAAICRCSQPLSGFSAR-CLEDEHLLQAISKANPVNRYMYVMD 238
Query: 236 TRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRW 295
TR A RA G G+E E +Y R IE H+++ SL KL+E + +++ +
Sbjct: 239 TRPKLNAMANRAAGKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDF 298
Query: 296 LSKLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRS 355
S LE+S WL HIK ++ A A+ I E AS+L+H ++G D T QV SL ++L+
Sbjct: 299 YSGLESSGWLRHIKAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYY 358
Query: 356 RTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSF 415
RTI+GF LIE++W+ GH F +RC Q + K +PVF FL+CVW + QFP +F
Sbjct: 359 RTIKGFMVLIEKDWISFGHKFSERCGQ---LDGDPKEVSPVFTQFLECVWHLTEQFPQAF 415
Query: 416 EFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLF 475
EF+E FL+ + EH ++ QFG FLGN + ER +LKL++KT SLW ++ + + K+ NPL+
Sbjct: 416 EFSEAFLLQIHEHIHSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLE--DQKKYLNPLY 473
Query: 476 EANN---LVIWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQAKVNIL 532
+ + V+ P+ + W ++ +++R+ + ++N+ E NK+L+ + L
Sbjct: 474 SSESHRFTVLEPNTVSFNFKFWRNMYHQFDRTLHPRQSVFNIIMNMNEQNKQLEKDIKDL 533
Query: 533 RRQLAE 538
++ +
Sbjct: 534 ESKIKQ 539
>gi|28872761 myotubularin-related protein 1 [Homo sapiens]
Length = 665
Score = 324 bits (831), Expect = 1e-88
Identities = 193/537 (35%), Positives = 292/537 (54%), Gaps = 17/537 (3%)
Query: 12 VDNVVLHRPFYPAVEGTLCLTGHHLILSS-RQDNTEELWLLHSNIDAIDKRFVGSLGT-- 68
V +V+ PF AV GTL +T L + +D L + I ++K S G
Sbjct: 110 VKDVMYICPFMGAVSGTLTVTDFKLYFKNVERDPHFILDVPLGVISRVEKIGAQSHGDNS 169
Query: 69 --IIIKCKDFRIIQLDIPGMEEC-LNIASSIEALS-TLDSITLMYPFFYRPMFEVIEDGW 124
I I CKD R ++L E+ L I ++ + L + ++ F Y+ F + +GW
Sbjct: 170 CGIEIVCKDMRNLRLAYKQEEQSKLGIFENLNKHAFPLSNGQALFAFSYKEKFPI--NGW 227
Query: 125 HSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGR 184
+ P E++ W++S +N + C +YP I+ VP S+ D+ L KVA FR GR
Sbjct: 228 KVYDPVSEYKRQGLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGR 287
Query: 185 FPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRGY---IIDTRSLNV 241
PVLS+ H ++ I R QPL G N +RCKEDEK + + A + + I D R +V
Sbjct: 288 VPVLSWIHPESQATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIFDARQNSV 347
Query: 242 AQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEA 301
A + KGGG+E E+ YP + I H+++ESL KL E RWLS ++
Sbjct: 348 ADTNKTKGGGYESESAYPNAELVFLEIHNIHVMRESLRKLKEIVYPSIDEA-RWLSNVDG 406
Query: 302 SNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGF 361
++WL +I+ +L A A I+ S+++H ++G D T Q+TSLA ++L+ RTI+GF
Sbjct: 407 THWLEYIRMLLAGAVRIADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGF 466
Query: 362 EALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENF 421
E L+E+EW+ GH F R N +P+FL F+DCVWQ+ RQFP +FEFNE F
Sbjct: 467 ETLVEKEWISFGHRFALRVGH-GNDNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELF 525
Query: 422 LIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLF-EANNL 480
LI + +H Y+ FGTFL N E +R K + KT+SLWS++N S+L +F+NP F N
Sbjct: 526 LITILDHLYSCLFGTFLCNCEQQRFKEDVYTKTISLWSYIN--SQLDEFSNPFFVNYENH 583
Query: 481 VIWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQAKVNILRRQLA 537
V++P + L LW ++RWN + ++ + ++ ELQ +V L+R++A
Sbjct: 584 VLYPVASLSHLELWVNYYVRWNPRMRPQMPIHQNLKELLAVRAELQKRVEGLQREVA 640
>gi|21361759 myotubularin related protein 8 [Homo sapiens]
Length = 704
Score = 320 bits (819), Expect = 3e-87
Identities = 187/541 (34%), Positives = 289/541 (53%), Gaps = 17/541 (3%)
Query: 7 IKTPRVDNVVLHRPFYPA--VEGTLCLTGHHLI-LSSRQDNTEELWLLHSNIDAIDKRFV 63
I P+V+NV L + G L LT HLI + + +E W+ +I ++K +
Sbjct: 4 ITVPKVENVKLVDRYVSKKPANGILYLTATHLIYVEASGAARKETWIALHHIATVEKLPI 63
Query: 64 GSLGT-IIIKCKDFRIIQLDIPGMEECLNIASSIEALSTLDSITLMYPFFYRPMF--EVI 120
SLG + ++CK+FR+ + C + S+ LS +Y F Y P E+
Sbjct: 64 TSLGCPLTLRCKNFRVAHFVLDSDLVCHEVYISLLKLSQPALPEDLYAFSYNPKSSKEMR 123
Query: 121 EDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFR 180
E GW P +F W ++ N+ + +C +YPP + VPKS+ + + FR
Sbjct: 124 ESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFR 183
Query: 181 HGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRG---YIIDTR 237
R PVLSY +K+N I R QPL+G RC +DE L+ A + Y++DTR
Sbjct: 184 SKERVPVLSYLYKENNAAICRCSQPLSGFY-TRCVDDELLLEAISQTNPGSQFMYVVDTR 242
Query: 238 SLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLS 297
A RA G G+E E +Y R IE H+++ SL KL+E C +T M +LS
Sbjct: 243 PKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLS 302
Query: 298 KLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRT 357
LE+S WL HIK I+ + + E AS+L+H ++G D T QV S+A I+L+P RT
Sbjct: 303 GLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRT 362
Query: 358 IRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEF 417
+G LIE+EW+ GH F QRC + + K +P+F FLDC+WQ++ QFPC+FEF
Sbjct: 363 FKGLMILIEKEWISMGHKFSQRC---GHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEF 419
Query: 418 NENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEA 477
NENFL+ + +H ++ QFG FLGN + +R L++ +KT S+W ++ Q F NPL++
Sbjct: 420 NENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQ--RKPDFRNPLYKG 477
Query: 478 NNL--VIWPSVAPQSLPLWEGIFLRWNRSSKYLDEAYEEMVNIIEYNKELQAKVNILRRQ 535
+ V+ PS P ++ W G++ R+++ + E ++ I + L+ V+ L ++
Sbjct: 478 FTMYGVLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKK 537
Query: 536 L 536
L
Sbjct: 538 L 538
>gi|4557896 myotubularin [Homo sapiens]
Length = 603
Score = 297 bits (761), Expect = 1e-80
Identities = 184/528 (34%), Positives = 285/528 (53%), Gaps = 30/528 (5%)
Query: 20 PFYPAVEGTLCLTGHHLILSSRQ-DNTEELWLLHSNIDAIDK------RFVGSLGTIIIK 72
PF ++G + +T + L L S + D++ L + I I+K R S G + I
Sbjct: 54 PFNGPIKGRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYG-LDIT 112
Query: 73 CKDFRIIQLDIPGMEECLNIASSIEALST----LDSITLMYPFFYRPMFEVIEDGWHSFL 128
CKD R ++ + +E + E L+ L ++ F F V DGW +
Sbjct: 113 CKDMRNLRFALK--QEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNV--DGWTVYN 168
Query: 129 PEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVL 188
P +E+ WR++++NK + +C +YP ++ VP D+ LR+VATFR R PVL
Sbjct: 169 PVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVL 228
Query: 189 SYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGK---RGYIIDTRSLNVAQQT 245
S+ H +N VI+R QPL G +G+R K+DEK ++ K + I D R A
Sbjct: 229 SWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVAN 288
Query: 246 RAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASNWL 305
+A GGG+E + Y I H+++ESL K+ + WLS LE+++WL
Sbjct: 289 KATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEE-SHWLSSLESTHWL 347
Query: 306 THIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALI 365
HIK +LT A A + +S+L+H ++G D T Q+TSLA ++L+ R+I GFE L+
Sbjct: 348 EHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILV 407
Query: 366 EREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIML 425
++EW+ GH F R +T +P+FL F+DCVWQ+ +QFP +FEFNE FLI++
Sbjct: 408 QKEWISFGHKFASRIGHGDKNHTDAD-RSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIII 466
Query: 426 FEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEAN-NLVIWP 484
+H Y+ +FGTFL N ES R + K+ ++T+SLWS +N E KF NP + N V++P
Sbjct: 467 LDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKE--KFKNPFYTKEINRVLYP 524
Query: 485 SVAPQSLPLWEGIFLRWNRSSKY-----LDEAYEEMVNI-IEYNKELQ 526
+ + L LW ++RWN K +++ Y E++ + EY K L+
Sbjct: 525 VASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLE 572
>gi|217272865 myotubularin related protein 4 [Homo sapiens]
Length = 1195
Score = 251 bits (640), Expect = 2e-66
Identities = 165/509 (32%), Positives = 248/509 (48%), Gaps = 77/509 (15%)
Query: 55 IDAIDKRFVGSLGTIIIKCKDFRIIQLDIPGMEECLNIASSIEALSTLDSITL------- 107
ID+++ R + L I CKD ++++ ++C E LS L T
Sbjct: 76 IDSVESRDMFQLH---ISCKDSKVVRCHFSTFKQCQ------EWLSRLSRATARPAKPED 126
Query: 108 MYPFFYRPM-FEVIEDGWHSFLPE--------QEFELYSSA---TSEWRLSYVNKEFAVC 155
++ F Y + E+ H+ L + QE EL + WR+S++N + +C
Sbjct: 127 LFAFAYHAWCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLC 186
Query: 156 PSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCK 215
PSYP + VP I D+ L VA+FR R PV+ Y H +NG I R QP G R
Sbjct: 187 PSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNA 246
Query: 216 EDEKLINATLRA-----GKRG--------------------------------------- 231
+DE L+ + +A G R
Sbjct: 247 DDEYLVTSIAKACALDPGTRATGGSLSTGNNDTSEACDADFDSSLTACSGVESTAAPQKL 306
Query: 232 YIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHN 291
I+D RS A RAKGGG E E +YP + + H ++ S L C+ Q +
Sbjct: 307 LILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCS-QMPD 365
Query: 292 MDRWLSKLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIIL 351
WLS LE++ WL H+ +L A L A +DREG +L+H ++G D T Q+ +LA+I+L
Sbjct: 366 PSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILL 425
Query: 352 EPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQF 411
+P RT+ GF+ L+E +WL GH F RC Q + PVFL +LD V Q+L+QF
Sbjct: 426 DPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVE-DQNEQCPVFLQWLDSVHQLLKQF 484
Query: 412 PCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFT 471
PC FEFNE FL+ L +H Y+ +GTFL NN ER K + ++T S+W+ + ++ F
Sbjct: 485 PCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNK--NFH 542
Query: 472 NPLF-EANNLVIWPSVAPQSLPLWEGIFL 499
N L+ ++++V+ P ++L LW ++L
Sbjct: 543 NFLYTPSSDMVLHPVCHVRALHLWTAVYL 571
>gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]
Length = 1161
Score = 240 bits (613), Expect = 2e-63
Identities = 151/493 (30%), Positives = 233/493 (47%), Gaps = 68/493 (13%)
Query: 71 IKCKDFRIIQLDIPGMEECLNIASSIE-ALSTLDSITLMYPFFYRPMF------------ 117
+ CKD ++I+ E+C + A+ I ++ F Y
Sbjct: 89 LTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHG 148
Query: 118 EVIEDGWH--SFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRK 175
++ G H S + + + WR+S +N+++ +C SYP + VP I D+ L
Sbjct: 149 DLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELES 208
Query: 176 VATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRA-------- 227
V++FR R P + Y H+ NG VI R GQP G R +DE L+ + +A
Sbjct: 209 VSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSS 268
Query: 228 ----------------------------------------GKRGYIIDTRSLNVAQQTRA 247
++ I+D RS A RA
Sbjct: 269 GSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRA 328
Query: 248 KGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASNWLTH 307
KGGG E +YP + + H ++ S L C Q + WLS LE++ WL H
Sbjct: 329 KGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCT-QMPDPGNWLSALESTKWLHH 387
Query: 308 IKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIER 367
+ +L +A L +D++ +L+H ++G D T Q+ +LA+++L+P RTI GF+ L+E
Sbjct: 388 LSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEM 447
Query: 368 EWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFE 427
EWL GH F RC + + PVFL +LDCV Q+ RQFPCSFEFNE FL+ L +
Sbjct: 448 EWLDFGHKFADRCGHGENSDDLNE-RCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQ 506
Query: 428 HAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEA-NNLVIWPSV 486
H Y+ FGTFL NN ER + Q++T S+WS + ++ F N L+ + + V++P
Sbjct: 507 HTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNK--AFKNLLYSSQSEAVLYPVC 564
Query: 487 APQSLPLWEGIFL 499
++L LW ++L
Sbjct: 565 HVRNLMLWSAVYL 577
>gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens]
Length = 1170
Score = 240 bits (613), Expect = 2e-63
Identities = 151/493 (30%), Positives = 233/493 (47%), Gaps = 68/493 (13%)
Query: 71 IKCKDFRIIQLDIPGMEECLNIASSIE-ALSTLDSITLMYPFFYRPMF------------ 117
+ CKD ++I+ E+C + A+ I ++ F Y
Sbjct: 89 LTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHG 148
Query: 118 EVIEDGWH--SFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRK 175
++ G H S + + + WR+S +N+++ +C SYP + VP I D+ L
Sbjct: 149 DLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELES 208
Query: 176 VATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRA-------- 227
V++FR R P + Y H+ NG VI R GQP G R +DE L+ + +A
Sbjct: 209 VSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSS 268
Query: 228 ----------------------------------------GKRGYIIDTRSLNVAQQTRA 247
++ I+D RS A RA
Sbjct: 269 GSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRA 328
Query: 248 KGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASNWLTH 307
KGGG E +YP + + H ++ S L C Q + WLS LE++ WL H
Sbjct: 329 KGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCT-QMPDPGNWLSALESTKWLHH 387
Query: 308 IKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIER 367
+ +L +A L +D++ +L+H ++G D T Q+ +LA+++L+P RTI GF+ L+E
Sbjct: 388 LSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEM 447
Query: 368 EWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFE 427
EWL GH F RC + + PVFL +LDCV Q+ RQFPCSFEFNE FL+ L +
Sbjct: 448 EWLDFGHKFADRCGHGENSDDLNE-RCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQ 506
Query: 428 HAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEA-NNLVIWPSV 486
H Y+ FGTFL NN ER + Q++T S+WS + ++ F N L+ + + V++P
Sbjct: 507 HTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNK--AFKNLLYSSQSEAVLYPVC 564
Query: 487 APQSLPLWEGIFL 499
++L LW ++L
Sbjct: 565 HVRNLMLWSAVYL 577
>gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]
Length = 1198
Score = 240 bits (613), Expect = 2e-63
Identities = 151/493 (30%), Positives = 233/493 (47%), Gaps = 68/493 (13%)
Query: 71 IKCKDFRIIQLDIPGMEECLNIASSIE-ALSTLDSITLMYPFFYRPMF------------ 117
+ CKD ++I+ E+C + A+ I ++ F Y
Sbjct: 89 LTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHG 148
Query: 118 EVIEDGWH--SFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRK 175
++ G H S + + + WR+S +N+++ +C SYP + VP I D+ L
Sbjct: 149 DLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELES 208
Query: 176 VATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRA-------- 227
V++FR R P + Y H+ NG VI R GQP G R +DE L+ + +A
Sbjct: 209 VSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSS 268
Query: 228 ----------------------------------------GKRGYIIDTRSLNVAQQTRA 247
++ I+D RS A RA
Sbjct: 269 GSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRA 328
Query: 248 KGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASNWLTH 307
KGGG E +YP + + H ++ S L C Q + WLS LE++ WL H
Sbjct: 329 KGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCT-QMPDPGNWLSALESTKWLHH 387
Query: 308 IKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIER 367
+ +L +A L +D++ +L+H ++G D T Q+ +LA+++L+P RTI GF+ L+E
Sbjct: 388 LSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEM 447
Query: 368 EWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFE 427
EWL GH F RC + + PVFL +LDCV Q+ RQFPCSFEFNE FL+ L +
Sbjct: 448 EWLDFGHKFADRCGHGENSDDLNE-RCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQ 506
Query: 428 HAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEA-NNLVIWPSV 486
H Y+ FGTFL NN ER + Q++T S+WS + ++ F N L+ + + V++P
Sbjct: 507 HTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNK--AFKNLLYSSQSEAVLYPVC 564
Query: 487 APQSLPLWEGIFL 499
++L LW ++L
Sbjct: 565 HVRNLMLWSAVYL 577
>gi|124028527 myotubularin related protein 10 [Homo sapiens]
Length = 777
Score = 159 bits (403), Expect = 5e-39
Identities = 123/469 (26%), Positives = 204/469 (43%), Gaps = 107/469 (22%)
Query: 69 IIIKCKDFRIIQL--DIPGMEECLNIASSIEALSTLDSITLMYPFFY------------- 113
+II CKDFRI++ D G E + +I S + L++ F Y
Sbjct: 134 LIIYCKDFRIVRFRFDESGPESAKKVCLAIAHYSQPTDLQLLFAFEYVGKKYHNSANKIN 193
Query: 114 ------------------------RPMFEVIEDGWHSFLPEQEFELYSSATSEWRLSYVN 149
P+FE D W + E+ + S WR+ +N
Sbjct: 194 GIPSGDGGGGGGGGNGAGGGSSQKTPLFETYSD-W-------DREIKRTGASGWRVCSIN 245
Query: 150 KEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGT 209
+ + + P + VP S+ D+ L+ + G R P+ + H NG ++R
Sbjct: 246 EGYMISTCLPEYIVVPSSLADQDLKIFSHSFVGRRMPLWCWSHS-NGSALVRMA------ 298
Query: 210 NGRRCKEDEKLINATLRAGKRGYIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKS-- 267
LI L+ K ID R N ++ +PQ ++KS
Sbjct: 299 ----------LIKDVLQQRK----IDQRICNAITKS------------HPQRSDVYKSDL 332
Query: 268 ---IERYHILQESLIKLVEACNDQT--HNMDRWLSKLEASNWLTHIKEILTTACLAAQCI 322
+ +Q + +KL + C ++ ++WLS LE + WL +++ L + +
Sbjct: 333 DKTLPNIQEVQAAFVKLKQLCVNEPFEETEEKWLSSLENTRWLEYVRAFLKHSAELVYML 392
Query: 323 DREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQ 382
+ + S+++ EG D + V SL Q++L+P RTI GF++LI++EW+ AG+ F RC
Sbjct: 393 ESKHLSVVLQEEEGRDLSCCVASLVQVMLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNH 452
Query: 383 SAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNE 442
+ + E+P+FLLFLD WQ+L Q+P +FEF+E +L +L++ S FGTFL N+
Sbjct: 453 L----KRSEKESPLFLLFLDATWQLLEQYPAAFEFSETYLAVLYDSTRISLFGTFLFNSP 508
Query: 443 SERCKLKLQ--------------QKTMSLWSWVNQ--PSELSKFTNPLF 475
+R K + K S+W W Q + + F NP +
Sbjct: 509 HQRVKQSTEFAISKNIQLGDEKGLKFPSVWDWSLQFTAKDRTLFHNPFY 557
>gi|224994251 myotubularin related protein 11 isoform a [Homo
sapiens]
Length = 709
Score = 150 bits (378), Expect = 4e-36
Identities = 108/335 (32%), Positives = 156/335 (46%), Gaps = 46/335 (13%)
Query: 115 PMFEVIEDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALR 174
P+ E ED W E E A WR+S VN+ F V S P VP I D +R
Sbjct: 194 PLMETAED-W-------ETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVR 245
Query: 175 KVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRGYI- 233
+ H GR P LS++H G ++R G T ++ KED + + L+AG +
Sbjct: 246 RAFGHFHQGRGPRLSWHHP-GGSDLLRCGGFYTASDPN--KEDIRAVELMLQAGHSDVVL 302
Query: 234 IDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEAC-NDQTHNM 292
+DT + +Q + ++L C D +
Sbjct: 303 VDTMD----------------------------ELPSLADVQLAHLRLRALCLPDSSVAE 334
Query: 293 DRWLSKLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILE 352
D+WLS LE + WL +++ L A + + S+++ D ++SL Q++
Sbjct: 335 DKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSA 394
Query: 353 PRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFP 412
P +RT+ GF++L++REW+ AGHPF R T EAPVFLLFLDCVWQ+L+QFP
Sbjct: 395 PEARTLFGFQSLVQREWVAAGHPFLTRLG-----GTGASEEAPVFLLFLDCVWQLLQQFP 449
Query: 413 CSFEFNENFLIMLFEHAYASQFGTFLGNNESERCK 447
FEF+E FL+ L + TFL N ER K
Sbjct: 450 ADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGK 484
>gi|89111941 myotubularin related protein 11 isoform b [Homo
sapiens]
Length = 640
Score = 150 bits (378), Expect = 4e-36
Identities = 108/335 (32%), Positives = 156/335 (46%), Gaps = 46/335 (13%)
Query: 115 PMFEVIEDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALR 174
P+ E ED W E E A WR+S VN+ F V S P VP I D +R
Sbjct: 122 PLMETAED-W-------ETERKKQAARGWRVSTVNERFDVATSLPRYFWVPNRILDSEVR 173
Query: 175 KVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKRGYI- 233
+ H GR P LS++H G ++R G T ++ KED + + L+AG +
Sbjct: 174 RAFGHFHQGRGPRLSWHHP-GGSDLLRCGGFYTASDPN--KEDIRAVELMLQAGHSDVVL 230
Query: 234 IDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEAC-NDQTHNM 292
+DT + +Q + ++L C D +
Sbjct: 231 VDTMD----------------------------ELPSLADVQLAHLRLRALCLPDSSVAE 262
Query: 293 DRWLSKLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILE 352
D+WLS LE + WL +++ L A + + S+++ D ++SL Q++
Sbjct: 263 DKWLSALEGTRWLDYVRACLRKASDISVLVTSRVRSVILQERGDRDLNGLLSSLVQLLSA 322
Query: 353 PRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFP 412
P +RT+ GF++L++REW+ AGHPF R T EAPVFLLFLDCVWQ+L+QFP
Sbjct: 323 PEARTLFGFQSLVQREWVAAGHPFLTRLG-----GTGASEEAPVFLLFLDCVWQLLQQFP 377
Query: 413 CSFEFNENFLIMLFEHAYASQFGTFLGNNESERCK 447
FEF+E FL+ L + TFL N ER K
Sbjct: 378 ADFEFSEFFLLALHDSVRVPDTLTFLRNTPWERGK 412
>gi|94721263 myotubularin related protein 12 [Homo sapiens]
Length = 747
Score = 127 bits (319), Expect = 3e-29
Identities = 114/446 (25%), Positives = 183/446 (41%), Gaps = 82/446 (18%)
Query: 69 IIIKCKDFRIIQ--LDIPGMEECLNIASSI----------------EALSTLDSITLMYP 110
+II CKD R+ Q L EE I S I + + T+ P
Sbjct: 139 LIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDP 198
Query: 111 FFYRPMFEVIEDGWHSFLPEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDD 170
+ MF+ ++D W L + + A S VN+ + VC P VP + +
Sbjct: 199 KNHTVMFDTLKD-WCWELERTKGNMKYKAVS------VNEGYKVCERLPAYFVVPTPLPE 251
Query: 171 EALRKVATFRHGGRFPVLSYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGKR 230
E +++ G P+ + ++ S P +G
Sbjct: 252 ENVQRF----QGHGIPIWCWSCHNGSALLKMSALPKEQDDG------------------- 288
Query: 231 GYIIDTRSLNVAQQTRAKGGGFEQEAHYPQWRRIHKS--IERYHILQE-----SLIKLVE 283
+ Q ++ G + H P + + + LQE S K +
Sbjct: 289 ----------ILQIQKSFLDGIYKTIHRPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQLF 338
Query: 284 ACNDQTHNMD---RWLSKLEASNWLTHIKEILTTACLAAQCIDREGASILIHGTEGTDST 340
++ T D +W S LE+S+WL I+ L A +C++ + ++L+ +D
Sbjct: 339 LIDNSTEFWDTDIKWFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLC 398
Query: 341 LQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLF 400
++SL Q++++P RT GF++LI++EW+ GH F RC + K E PVFLLF
Sbjct: 399 CLISSLVQLMMDPHCRTRIGFQSLIQKEWVMGGHCFLDRC---NHLRQNDKEEVPVFLLF 455
Query: 401 LDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESE------RCKLKLQQKT 454
LDCVWQ++ Q P +FEF E +L +L + Y F TF N+ + R Q K
Sbjct: 456 LDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKP 515
Query: 455 MSL---WSWVNQ--PSELSKFTNPLF 475
++L W W Q P + NPL+
Sbjct: 516 LNLLTVWDWSVQFEPKAQTLLKNPLY 541
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 121 bits (303), Expect = 2e-27
Identities = 81/236 (34%), Positives = 127/236 (53%), Gaps = 17/236 (7%)
Query: 274 LQESLIKLVEACNDQTHNMDRWLSKLEA---SNWLTHIKEILTTACLAAQCIDREGASIL 330
++ S KL+ AC T D ++ L+A S W + I+ A + ++ ++ G+S+L
Sbjct: 1349 VKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAVVVSEVLEN-GSSVL 1407
Query: 331 IHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHPFQQRCAQSAYCNTKQ 390
+ EG D T QVTSL Q++ +P RT+ GF+ L+E+EWL GH F QR S N +
Sbjct: 1408 VCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKFSQR--SSLTLNCQG 1465
Query: 391 KWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFGTFLGNNESERCK--- 447
APVFL FLDCV Q+ Q+P FEFN +L L H +++F TFL +++ ER +
Sbjct: 1466 SGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTFLLDSDYERLEHGT 1525
Query: 448 ------LKLQQKTMSLWSWVNQPSELSK-FTNPLFEANNL-VIWPSVAPQSLPLWE 495
K +K + +W +++ + S F N L+ + + P+V SL W+
Sbjct: 1526 LFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNVNVSSLKKWD 1581
Score = 48.9 bits (115), Expect = 1e-05
Identities = 19/61 (31%), Positives = 41/61 (67%)
Query: 143 WRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKNGMVIMRS 202
+R++ N+ +++C SYP ++ VP+++ D +L +VA R PV+ + + ++G +++RS
Sbjct: 1138 FRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRS 1197
Query: 203 G 203
G
Sbjct: 1198 G 1198
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 118 bits (295), Expect = 2e-26
Identities = 81/259 (31%), Positives = 126/259 (48%), Gaps = 30/259 (11%)
Query: 260 QWRRIHKSIERYHILQESLIKLVEACNDQTHNMD----RWLSKLEASNWLTHIKEILTTA 315
QW + + ++ S KL++AC + +L LE S WL I ++L +
Sbjct: 1371 QWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSPASFLRSLEDSEWLIQIHKLLQVS 1430
Query: 316 CLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAGHP 375
L + +D G+S+L+ +G D T QV SL Q++ +P RT+ GF L+E+EWL GH
Sbjct: 1431 VLVVELLD-SGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHR 1489
Query: 376 FQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIMLFEHAYASQFG 435
F R A + + PVFL FLDCV Q+ QFP FEF++ +L L H + +F
Sbjct: 1490 FSHRGAHT--LAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFR 1547
Query: 436 TFLGNNESERCKLKL----------QQKTMSLWSWVNQPS-------------ELSKFTN 472
TFL +++ ER +L L Q S+W +V++ S E ++
Sbjct: 1548 TFLLDSDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLR 1607
Query: 473 PLFEANNLVIWPSVAPQSL 491
P +NL +W ++L
Sbjct: 1608 PYSNVSNLKVWDFYTEETL 1626
Score = 55.8 bits (133), Expect = 1e-07
Identities = 28/68 (41%), Positives = 46/68 (67%), Gaps = 1/68 (1%)
Query: 137 SSATSE-WRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVLSYYHKKN 195
S A SE +R+S VN+ +A+C SYP ++ VP+S+ D AL++V+ RFPV+ + ++
Sbjct: 1143 SRAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRS 1202
Query: 196 GMVIMRSG 203
V++RSG
Sbjct: 1203 KAVLLRSG 1210
>gi|54112397 calcium channel, voltage-dependent, alpha 2/delta 3
subunit [Homo sapiens]
Length = 1091
Score = 30.0 bits (66), Expect = 5.7
Identities = 31/120 (25%), Positives = 51/120 (42%), Gaps = 16/120 (13%)
Query: 269 ERYHILQESLIKLVEA---CNDQTHNMDRWLSKLEASNWLTH------------IKEILT 313
E H L+ + L + CN H R LS+LEA I+E+L
Sbjct: 637 EGLHDLEHPDVSLADEWSYCNTDLHPEHRHLSQLEAIKLYLKGKEPLLQCDKELIQEVLF 696
Query: 314 TACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALIEREWLQAG 373
A ++A I+ S+ ++ +E +D ++V L R G E L +++L+AG
Sbjct: 697 DAVVSAP-IEAYWTSLALNKSENSDKGVEVAFLGTRTGLSRINLFVGAEQLTNQDFLKAG 755
>gi|122937311 solute carrier family 35, member F4 [Homo sapiens]
Length = 521
Score = 30.0 bits (66), Expect = 5.7
Identities = 11/44 (25%), Positives = 27/44 (61%), Gaps = 2/44 (4%)
Query: 33 GHHLILSSRQDNTEELWLLHSNIDAIDK--RFVGSLGTIIIKCK 74
GH++++ R+++ +WL+HS + + F+G+ + + +CK
Sbjct: 38 GHNILVKMRKEDKSLVWLIHSTLARYTQVTNFLGTSRSSVTRCK 81
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 29.6 bits (65), Expect = 7.5
Identities = 21/54 (38%), Positives = 28/54 (51%), Gaps = 4/54 (7%)
Query: 323 DREGASILIHGTEG---TDSTLQVTS-LAQIILEPRSRTIRGFEALIEREWLQA 372
DRE SIL G G T++T +V LA + P+ R G +ER+ LQA
Sbjct: 188 DREDQSILCTGESGAGKTENTKKVIQYLAHVASSPKGRKEPGVPGELERQLLQA 241
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,800,220
Number of Sequences: 37866
Number of extensions: 892803
Number of successful extensions: 2293
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 2202
Number of HSP's gapped (non-prelim): 38
length of query: 549
length of database: 18,247,518
effective HSP length: 107
effective length of query: 442
effective length of database: 14,195,856
effective search space: 6274568352
effective search space used: 6274568352
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.