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Search of human proteins with 19743806
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19743806 roundabout 1 isoform b [Homo sapiens]
(1612 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19743806 roundabout 1 isoform b [Homo sapiens] 3284 0.0
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 3274 0.0
gi|224994171 roundabout 1 isoform c [Homo sapiens] 3252 0.0
gi|4506569 roundabout 1 isoform a [Homo sapiens] 3246 0.0
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 3118 0.0
gi|224994173 roundabout 1 isoform d [Homo sapiens] 3092 0.0
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 1397 0.0
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 1397 0.0
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 959 0.0
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 237 6e-62
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 229 1e-59
gi|157311649 neogenin homolog 1 [Homo sapiens] 223 1e-57
gi|118572606 hemicentin 1 [Homo sapiens] 221 4e-57
gi|28373129 contactin 5 isoform short [Homo sapiens] 219 1e-56
gi|7657359 contactin 5 isoform long [Homo sapiens] 219 2e-56
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 208 3e-53
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 208 4e-53
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 208 4e-53
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 207 5e-53
gi|109150416 peroxidasin [Homo sapiens] 206 2e-52
gi|222352127 sidekick 2 [Homo sapiens] 204 7e-52
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 203 1e-51
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 203 1e-51
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 203 1e-51
gi|75709184 contactin 3 [Homo sapiens] 203 1e-51
gi|119220552 sidekick 1 [Homo sapiens] 203 1e-51
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 200 1e-50
gi|7657361 contactin 6 [Homo sapiens] 194 8e-49
gi|126517478 peroxidasin homolog-like [Homo sapiens] 193 1e-48
gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens] 192 2e-48
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 3284 bits (8515), Expect = 0.0
Identities = 1612/1612 (100%), Positives = 1612/1612 (100%)
Query: 1 MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI
Sbjct: 1 MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
Query: 61 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH
Sbjct: 61 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
Query: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT
Sbjct: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
Query: 181 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA
Sbjct: 181 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA
Sbjct: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
Query: 301 EASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 360
EASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP
Sbjct: 301 EASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 360
Query: 361 QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ 420
QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ
Sbjct: 361 QSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ 420
Query: 421 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD 480
GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD
Sbjct: 421 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGD 480
Query: 481 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 540
TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL
Sbjct: 481 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 540
Query: 541 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA 600
SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA
Sbjct: 541 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA 600
Query: 601 YGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ 660
YGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ
Sbjct: 601 YGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ 660
Query: 661 QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQ 720
QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQ
Sbjct: 661 QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQ 720
Query: 721 GADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLG 780
GADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLG
Sbjct: 721 GADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLG 780
Query: 781 NETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVS 840
NETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVS
Sbjct: 781 NETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVS 840
Query: 841 PEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVP 900
PEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVP
Sbjct: 841 PEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVP 900
Query: 901 SFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGN 960
SFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGN
Sbjct: 901 SFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGN 960
Query: 961 GNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLK 1020
GNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLK
Sbjct: 961 GNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLK 1020
Query: 1021 DGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQ 1080
DGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQ
Sbjct: 1021 DGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQ 1080
Query: 1081 NKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGG 1140
NKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGG
Sbjct: 1081 NKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGG 1140
Query: 1141 MNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGP 1200
MNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGP
Sbjct: 1141 MNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGP 1200
Query: 1201 TPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPP 1260
TPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPP
Sbjct: 1201 TPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPP 1260
Query: 1261 PPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSV 1320
PPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSV
Sbjct: 1261 PPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSV 1320
Query: 1321 GDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVA 1380
GDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVA
Sbjct: 1321 GDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVA 1380
Query: 1381 RRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDD 1440
RRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDD
Sbjct: 1381 RRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDD 1440
Query: 1441 LPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQ 1500
LPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQ
Sbjct: 1441 LPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQ 1500
Query: 1501 VVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPR 1560
VVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPR
Sbjct: 1501 VVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPR 1560
Query: 1561 DPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1612
DPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1561 DPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1612
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 3274 bits (8488), Expect = 0.0
Identities = 1610/1615 (99%), Positives = 1610/1615 (99%), Gaps = 3/1615 (0%)
Query: 1 MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI
Sbjct: 1 MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
Query: 61 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH
Sbjct: 61 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
Query: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT
Sbjct: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
Query: 181 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA
Sbjct: 181 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA
Sbjct: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
Query: 301 EASATLTVQ---EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357
EASATLTVQ EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY
Sbjct: 301 EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360
Query: 358 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 417
QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420
Query: 418 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477
IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
Query: 478 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 537
LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
Query: 538 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 597
VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
Query: 598 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 657
ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 658 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 717
VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN
Sbjct: 661 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
Query: 718 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 777
EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW
Sbjct: 721 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
Query: 778 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 837
CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN
Sbjct: 781 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840
Query: 838 PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 897
PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR
Sbjct: 841 PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900
Query: 898 KVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 957
KVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT
Sbjct: 901 KVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 960
Query: 958 AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP 1017
AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP
Sbjct: 961 AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP 1020
Query: 1018 NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1077
NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI
Sbjct: 1021 NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1080
Query: 1078 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1137
VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK
Sbjct: 1081 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1140
Query: 1138 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE 1197
QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPAR YLQQDELEEEEDE
Sbjct: 1141 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARTYLQQDELEEEEDE 1200
Query: 1198 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1257
RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV
Sbjct: 1201 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1260
Query: 1258 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1317
SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA
Sbjct: 1261 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1320
Query: 1318 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1377
SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL
Sbjct: 1321 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1380
Query: 1378 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1437
KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY
Sbjct: 1381 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1440
Query: 1438 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD 1497
TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVL
Sbjct: 1441 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLG 1500
Query: 1498 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1557
GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN
Sbjct: 1501 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1560
Query: 1558 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1612
NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1561 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1615
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 3252 bits (8432), Expect = 0.0
Identities = 1603/1615 (99%), Positives = 1603/1615 (99%), Gaps = 12/1615 (0%)
Query: 1 MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI
Sbjct: 1 MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
Query: 61 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH
Sbjct: 61 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
Query: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT
Sbjct: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
Query: 181 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA
Sbjct: 181 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA
Sbjct: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
Query: 301 EASATLTVQ---EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357
EASATLTVQ EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY
Sbjct: 301 EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360
Query: 358 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 417
QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420
Query: 418 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477
IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
Query: 478 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 537
LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
Query: 538 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 597
VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
Query: 598 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 657
ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 658 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 717
VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN
Sbjct: 661 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
Query: 718 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 777
EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW
Sbjct: 721 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
Query: 778 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 837
CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN
Sbjct: 781 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840
Query: 838 PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 897
PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR
Sbjct: 841 PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900
Query: 898 KVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 957
KV TYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT
Sbjct: 901 KV---------TYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 951
Query: 958 AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP 1017
AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP
Sbjct: 952 AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP 1011
Query: 1018 NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1077
NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI
Sbjct: 1012 NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1071
Query: 1078 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1137
VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK
Sbjct: 1072 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1131
Query: 1138 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE 1197
QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE
Sbjct: 1132 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE 1191
Query: 1198 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1257
RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV
Sbjct: 1192 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1251
Query: 1258 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1317
SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA
Sbjct: 1252 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1311
Query: 1318 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1377
SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL
Sbjct: 1312 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1371
Query: 1378 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1437
KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY
Sbjct: 1372 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1431
Query: 1438 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD 1497
TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD
Sbjct: 1432 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD 1491
Query: 1498 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1557
GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN
Sbjct: 1492 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1551
Query: 1558 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1612
NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1552 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1606
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 3246 bits (8416), Expect = 0.0
Identities = 1594/1595 (99%), Positives = 1595/1595 (100%)
Query: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
+GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR
Sbjct: 57 TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116
Query: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP
Sbjct: 117 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176
Query: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG
Sbjct: 177 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 236
Query: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR
Sbjct: 237 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
Query: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 317
KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK
Sbjct: 297 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 356
Query: 318 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 377
PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT
Sbjct: 357 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 416
Query: 378 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 437
NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC
Sbjct: 417 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 476
Query: 438 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 497
VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW
Sbjct: 477 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 536
Query: 498 SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII 557
SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII
Sbjct: 537 SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII 596
Query: 558 EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQD 617
EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQD
Sbjct: 597 EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQD 656
Query: 618 VLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGA 677
VLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGA
Sbjct: 657 VLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGA 716
Query: 678 NHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPS 737
NHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPS
Sbjct: 717 NHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPS 776
Query: 738 APPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 797
APPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS
Sbjct: 777 APPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 836
Query: 798 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ 857
VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ
Sbjct: 837 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ 896
Query: 858 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAV 917
PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAV
Sbjct: 897 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAV 956
Query: 918 SSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCI 977
SSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCI
Sbjct: 957 SSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCI 1016
Query: 978 ANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATT 1037
ANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATT
Sbjct: 1017 ANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATT 1076
Query: 1038 QLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTI 1097
QLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTI
Sbjct: 1077 QLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTI 1136
Query: 1098 PYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPH 1157
PYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPH
Sbjct: 1137 PYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPH 1196
Query: 1158 SNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYS 1217
SNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYS
Sbjct: 1197 SNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYS 1256
Query: 1218 HQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISG 1277
HQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISG
Sbjct: 1257 HQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISG 1316
Query: 1278 PLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGS 1337
PLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGS
Sbjct: 1317 PLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGS 1376
Query: 1338 ASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQ 1397
ASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQ
Sbjct: 1377 ASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQ 1436
Query: 1398 CPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQ 1457
CPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQ
Sbjct: 1437 CPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQ 1496
Query: 1458 SKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQ 1517
SKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQ
Sbjct: 1497 SKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQ 1556
Query: 1518 QNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQ 1577
QNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQ
Sbjct: 1557 QNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQ 1616
Query: 1578 REQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1612
REQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1617 REQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1651
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 3118 bits (8083), Expect = 0.0
Identities = 1549/1615 (95%), Positives = 1550/1615 (95%), Gaps = 56/1615 (3%)
Query: 1 MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI
Sbjct: 1 MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
Query: 61 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH
Sbjct: 61 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
Query: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT
Sbjct: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
Query: 181 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA
Sbjct: 181 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA
Sbjct: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
Query: 301 EASATLTVQ---EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357
EASATLTVQ EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY
Sbjct: 301 EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360
Query: 358 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 417
QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420
Query: 418 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477
IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
Query: 478 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 537
LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
Query: 538 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 597
VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
Query: 598 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 657
ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 658 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 717
VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN
Sbjct: 661 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
Query: 718 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 777
EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW
Sbjct: 721 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
Query: 778 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 837
CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN
Sbjct: 781 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840
Query: 838 PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 897
PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR
Sbjct: 841 PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900
Query: 898 KVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 957
KVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT
Sbjct: 901 KVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 960
Query: 958 AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP 1017
AGNGNSDSNLTTYSRPAD + T Y L
Sbjct: 961 AGNGNSDSNLTTYSRPADW------------------QPTPYATTQL------------- 989
Query: 1018 NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1077
IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI
Sbjct: 990 ----------------------IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1027
Query: 1078 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1137
VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK
Sbjct: 1028 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1087
Query: 1138 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE 1197
QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPAR YLQQDELEEEEDE
Sbjct: 1088 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARTYLQQDELEEEEDE 1147
Query: 1198 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1257
RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV
Sbjct: 1148 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1207
Query: 1258 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1317
SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA
Sbjct: 1208 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1267
Query: 1318 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1377
SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL
Sbjct: 1268 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1327
Query: 1378 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1437
KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY
Sbjct: 1328 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1387
Query: 1438 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD 1497
TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVL
Sbjct: 1388 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLG 1447
Query: 1498 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1557
GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN
Sbjct: 1448 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1507
Query: 1558 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1612
NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1508 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1562
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 3092 bits (8017), Expect = 0.0
Identities = 1540/1615 (95%), Positives = 1541/1615 (95%), Gaps = 67/1615 (4%)
Query: 1 MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI
Sbjct: 1 MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTI 60
Query: 61 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH
Sbjct: 61 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 120
Query: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT
Sbjct: 121 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 180
Query: 181 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA
Sbjct: 181 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 240
Query: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA
Sbjct: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKA 300
Query: 301 EASATLTVQ---EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357
EASATLTVQ EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY
Sbjct: 301 EASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 360
Query: 358 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 417
QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV
Sbjct: 361 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 420
Query: 418 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477
IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK
Sbjct: 421 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 480
Query: 478 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 537
LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT
Sbjct: 481 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 540
Query: 538 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 597
VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA
Sbjct: 541 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRA 600
Query: 598 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 657
ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT
Sbjct: 601 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT 660
Query: 658 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 717
VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN
Sbjct: 661 VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 720
Query: 718 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 777
EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW
Sbjct: 721 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 780
Query: 778 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 837
CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN
Sbjct: 781 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGN 840
Query: 838 PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 897
PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR
Sbjct: 841 PVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIR 900
Query: 898 KVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 957
K VTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT
Sbjct: 901 K---------VTYQRGGEAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCT 951
Query: 958 AGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSP 1017
AGNGNSDSNLTTYSRP + T Y L
Sbjct: 952 AGNGNSDSNLTTYSRPG--------------------QPTPYATTQL------------- 978
Query: 1018 NLKDGRFVNPSGQPTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1077
IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI
Sbjct: 979 ----------------------IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNI 1016
Query: 1078 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1137
VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK
Sbjct: 1017 VEQNKLNKDYRANDTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPK 1076
Query: 1138 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE 1197
QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE
Sbjct: 1077 QGGMNWADLLPPPPAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDE 1136
Query: 1198 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1257
RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV
Sbjct: 1137 RGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPV 1196
Query: 1258 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1317
SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA
Sbjct: 1197 SPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPA 1256
Query: 1318 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1377
SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL
Sbjct: 1257 SSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGL 1316
Query: 1378 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1437
KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY
Sbjct: 1317 KVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETY 1376
Query: 1438 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD 1497
TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD
Sbjct: 1377 TDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLD 1436
Query: 1498 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1557
GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN
Sbjct: 1437 GRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSN 1496
Query: 1558 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1612
NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1497 NPRDPSSSSSMSSRGSGSRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1551
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 1397 bits (3615), Expect = 0.0
Identities = 762/1462 (52%), Positives = 949/1462 (64%), Gaps = 170/1462 (11%)
Query: 19 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 78
GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 37 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 96
Query: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 97 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 156
Query: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
DV+VA GEPA++ECQPPRGHPEPTI WKKD +DDK+ERI+IRGGKLMI+ TRKSDAG
Sbjct: 157 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 216
Query: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Y CVGTNMVGER+S+ AELTV ERP+F++RP N V +++ EF+C+ +GDP PTVRW+K
Sbjct: 217 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 276
Query: 259 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP 318
DD +LP+ RY+I+DD+TL+I+K + D G+Y C+AEN VGK EASATLTV+ PP FVV+P
Sbjct: 277 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 336
Query: 319 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 378
RDQ+VA GRTVTF CE GNPQPA+FW++EGSQNLLF QP Q +SR SVS TGDLTITN
Sbjct: 337 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 396
Query: 379 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 438
+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L C
Sbjct: 397 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 456
Query: 439 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 498
ATG P+P I W K+G +D R E G LQI+ ++ DTG YTC+A++ SGE +WS
Sbjct: 457 ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWS 516
Query: 499 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 558
A ++V E G + + D + +P PSKP+VTDV++N+VTLSWQP ++YIIE
Sbjct: 517 AVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIE 574
Query: 559 AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDV 618
AFS + +SWQTVA +VKT ++GL+PN IYLF+VRA N G+SDPS +SDPV+TQD+
Sbjct: 575 AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDI 634
Query: 619 LPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGAN 678
P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 635 SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGL 694
Query: 679 HGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA 738
S W + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K +T EEAPSA
Sbjct: 695 QATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSA 754
Query: 739 PPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 797
PPQ VTV + N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD + S
Sbjct: 755 PPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRS 814
Query: 798 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ 857
V+I L PGI+Y VEVAAST AG GVKSEPQ I + V E+ S+ +QI+DVVKQ
Sbjct: 815 VIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQ 874
Query: 858 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRG-GEA 916
PAFIAGIG ACW+ILM FSIWLY RKKR GL S YA VT+QRG G
Sbjct: 875 PAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA-------------VTFQRGDGGL 920
Query: 917 VSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADC 976
+S+G RPGLLN +P + PWLAD+WP T N NS N D
Sbjct: 921 MSNGSRPGLLNAGDP-SYPWLADSWPATS----------LPVNNSNSGPNEIGNFGRGDV 969
Query: 977 IANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYAT 1036
+ Q D +T ML + +Y +D + K ++NS + Q TPYAT
Sbjct: 970 LPPVPGQGD--KTATMLSDGAIYSSIDFTTK----TSYNSS--------SQITQATPYAT 1015
Query: 1037 TQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPT 1096
TQ++ SN+++ + D + WK QQK ++ Y++ +QNK
Sbjct: 1016 TQILH---SNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNK-------------- 1058
Query: 1097 IPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL-LPPPPAHPP 1155
N GG KK + K K G WA++ LPPPP P
Sbjct: 1059 --------GNNGGKGGKK------------KKNKNSSKPQKNNGSTWANVPLPPPPVQPL 1098
Query: 1156 PHSNSEEYNISVDES-YDQEMPCPVPPARMYLQQ---DELEEEEDERGPTPPVRGAASSP 1211
P + E Y + E+ YD + CP P + YL Q DEL EE+D+R PTPPVRG ASSP
Sbjct: 1099 PGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVASSP 1157
Query: 1212 AAVSYSHQSTATLTPSPQEELQPMLQ------------DCPEETGHMQHQPDRRRQPVSP 1259
A+S+ QSTATLTPSP+EE+QPMLQ D ++T H+Q QP P
Sbjct: 1158 -AISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQ----SNNQPPQP 1212
Query: 1260 PPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASS 1319
P PP GY+SG L+SD++TD +D+AD E ++ R LR L+QTP SS
Sbjct: 1213 PVPP--------LGYVSGALISDLETDV---ADDDADDEEEALEIPR-PLRALDQTPGSS 1260
Query: 1320 VGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKV 1379
+ +L+SSVTG SS R +S F TD++ + A++
Sbjct: 1261 MDNLDSSVTGKAFT-----------SSQRPRPTS---PFSTDSNTSAALS---------- 1296
Query: 1380 ARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRETYT 1438
SQ PRPT K ++ QP RRE T
Sbjct: 1297 ---------------QSQRPRPT---------------KKHKGGRMDQQPALPHRREGMT 1326
Query: 1439 DDLPPPPVPPPAIKSPTAQSKT 1460
D+ P P+ SP S +
Sbjct: 1327 DEEALVPYSKPSFPSPGGHSSS 1348
Score = 90.1 bits (222), Expect = 2e-17
Identities = 62/201 (30%), Positives = 87/201 (43%), Gaps = 10/201 (4%)
Query: 298 GKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357
G+ + S PP V P D +V+ G T C+A G P P I W ++G +
Sbjct: 33 GQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKD 92
Query: 358 QPPQSSSRFSVSQTGDLTITNVQRS--DVGYYICQTLNVAGSIITK-AYLEVTDVIADRP 414
P L I + +RS D G Y+C N G +++ A LEV + D
Sbjct: 93 DPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-- 150
Query: 415 PPVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 473
RQ P + VA +L C G P PTI W+KD V + ++ RI + G L I
Sbjct: 151 ---FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERI-SIRGGKLMI 206
Query: 474 RYAKLGDTGRYTCIASTPSGE 494
+ D G YTC+ + GE
Sbjct: 207 SNTRKSDAGMYTCVGTNMVGE 227
Score = 47.8 bits (112), Expect = 9e-05
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 1442 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1491
P PPVPP +++ A E + +P+ L ++D S D SS
Sbjct: 1210 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1269
Query: 1492 GREVLDG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1543
G+ R T+ + Q + +K + D PA H +E
Sbjct: 1270 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1329
Query: 1544 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1595
++PY +P+FP +P SSS + SS+GS G R+ E G +RN +++ +G
Sbjct: 1330 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1380
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 1397 bits (3615), Expect = 0.0
Identities = 762/1462 (52%), Positives = 949/1462 (64%), Gaps = 170/1462 (11%)
Query: 19 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 78
GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 21 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 80
Query: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140
Query: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
DV+VA GEPA++ECQPPRGHPEPTI WKKD +DDK+ERI+IRGGKLMI+ TRKSDAG
Sbjct: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
Query: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 258
Y CVGTNMVGER+S+ AELTV ERP+F++RP N V +++ EF+C+ +GDP PTVRW+K
Sbjct: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260
Query: 259 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP 318
DD +LP+ RY+I+DD+TL+I+K + D G+Y C+AEN VGK EASATLTV+ PP FVV+P
Sbjct: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 320
Query: 319 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 378
RDQ+VA GRTVTF CE GNPQPA+FW++EGSQNLLF QP Q +SR SVS TGDLTITN
Sbjct: 321 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 380
Query: 379 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 438
+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L C
Sbjct: 381 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 440
Query: 439 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 498
ATG P+P I W K+G +D R E G LQI+ ++ DTG YTC+A++ SGE +WS
Sbjct: 441 ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWS 500
Query: 499 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 558
A ++V E G + + D + +P PSKP+VTDV++N+VTLSWQP ++YIIE
Sbjct: 501 AVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIE 558
Query: 559 AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDV 618
AFS + +SWQTVA +VKT ++GL+PN IYLF+VRA N G+SDPS +SDPV+TQD+
Sbjct: 559 AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDI 618
Query: 619 LPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGAN 678
P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 619 SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGL 678
Query: 679 HGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA 738
S W + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K +T EEAPSA
Sbjct: 679 QATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSA 738
Query: 739 PPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 797
PPQ VTV + N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD + S
Sbjct: 739 PPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRS 798
Query: 798 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ 857
V+I L PGI+Y VEVAAST AG GVKSEPQ I + V E+ S+ +QI+DVVKQ
Sbjct: 799 VIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQ 858
Query: 858 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRG-GEA 916
PAFIAGIG ACW+ILM FSIWLY RKKR GL S YA VT+QRG G
Sbjct: 859 PAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA-------------VTFQRGDGGL 904
Query: 917 VSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADC 976
+S+G RPGLLN +P + PWLAD+WP T N NS N D
Sbjct: 905 MSNGSRPGLLNAGDP-SYPWLADSWPATS----------LPVNNSNSGPNEIGNFGRGDV 953
Query: 977 IANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYAT 1036
+ Q D +T ML + +Y +D + K ++NS + Q TPYAT
Sbjct: 954 LPPVPGQGD--KTATMLSDGAIYSSIDFTTK----TSYNSS--------SQITQATPYAT 999
Query: 1037 TQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPT 1096
TQ++ SN+++ + D + WK QQK ++ Y++ +QNK
Sbjct: 1000 TQILH---SNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNK-------------- 1042
Query: 1097 IPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL-LPPPPAHPP 1155
N GG KK + K K G WA++ LPPPP P
Sbjct: 1043 --------GNNGGKGGKK------------KKNKNSSKPQKNNGSTWANVPLPPPPVQPL 1082
Query: 1156 PHSNSEEYNISVDES-YDQEMPCPVPPARMYLQQ---DELEEEEDERGPTPPVRGAASSP 1211
P + E Y + E+ YD + CP P + YL Q DEL EE+D+R PTPPVRG ASSP
Sbjct: 1083 PGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVASSP 1141
Query: 1212 AAVSYSHQSTATLTPSPQEELQPMLQ------------DCPEETGHMQHQPDRRRQPVSP 1259
A+S+ QSTATLTPSP+EE+QPMLQ D ++T H+Q QP P
Sbjct: 1142 -AISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQ----SNNQPPQP 1196
Query: 1260 PPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASS 1319
P PP GY+SG L+SD++TD +D+AD E ++ R LR L+QTP SS
Sbjct: 1197 PVPP--------LGYVSGALISDLETDV---ADDDADDEEEALEIPR-PLRALDQTPGSS 1244
Query: 1320 VGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKV 1379
+ +L+SSVTG SS R +S F TD++ + A++
Sbjct: 1245 MDNLDSSVTGKAFT-----------SSQRPRPTS---PFSTDSNTSAALS---------- 1280
Query: 1380 ARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRETYT 1438
SQ PRPT K ++ QP RRE T
Sbjct: 1281 ---------------QSQRPRPT---------------KKHKGGRMDQQPALPHRREGMT 1310
Query: 1439 DDLPPPPVPPPAIKSPTAQSKT 1460
D+ P P+ SP S +
Sbjct: 1311 DEEALVPYSKPSFPSPGGHSSS 1332
Score = 47.8 bits (112), Expect = 9e-05
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 1442 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1491
P PPVPP +++ A E + +P+ L ++D S D SS
Sbjct: 1194 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1253
Query: 1492 GREVLDG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1543
G+ R T+ + Q + +K + D PA H +E
Sbjct: 1254 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1313
Query: 1544 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1595
++PY +P+FP +P SSS + SS+GS G R+ E G +RN +++ +G
Sbjct: 1314 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1364
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 959 bits (2478), Expect = 0.0
Identities = 550/1252 (43%), Positives = 742/1252 (59%), Gaps = 124/1252 (9%)
Query: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
+GSR+ ED PRIVE P DL+VS+GEPATL C+AEGRP P IEWYK G RV T ++DPR
Sbjct: 53 NGSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPR 112
Query: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
+HR+LLPSG+LFF RIVHGR++RPDEGVY CVARNYLG A S NASLEVA+LRDDFRQ+P
Sbjct: 113 AHRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSP 172
Query: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
+V+VAVGEPAV+EC PPRGHPEP++SW+KDG+ L +++ RITIRGGKLM+++T KSDAG
Sbjct: 173 GNVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAG 232
Query: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
YVCV +NM GERES AE+ VLERPSF++RP N V D F CE +GDP P +RWR
Sbjct: 233 MYVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWR 292
Query: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 317
K+DGELP RYEIR DH+L I V+A D G+YTCVAEN VG+AEAS +L+V PP V +
Sbjct: 293 KEDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQ 352
Query: 318 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 377
P+DQ+ A G +V FQCE GNP PAIFW++EGSQ LLF Q Q + RFSVS G L IT
Sbjct: 353 PQDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNIT 412
Query: 378 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 437
VQR D GYY+CQ ++VAGSI+ KA LE+ D PPVI QGP NQT+ + + L C
Sbjct: 413 AVQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPC 472
Query: 438 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 497
TG+P P++ W+KDG + D + K + NG L I + D G Y+C+A + +GEATW
Sbjct: 473 RVTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATW 532
Query: 498 SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII 557
S +++++E V P PT+P+ P APS+P VT++++N++TL+W+PN +GA TSY+I
Sbjct: 533 SGWLKMRE-DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVI 591
Query: 558 EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQD 617
EAFS A+G++W+TVA+ V+ ET + GL+PN IYLFLVRA A+G+S+PS +S+PV+TQD
Sbjct: 592 EAFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQD 651
Query: 618 VLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGA 677
P+ D + Q+ L + L P VL +++V WTVD Q +QG+++ +R +G
Sbjct: 652 SSPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGP 711
Query: 678 NHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPS 737
G W + ++++P++ S V+ L G +IK + E GA+S EEAPS
Sbjct: 712 EGG--SWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPS 769
Query: 738 APPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 797
PPQGV V+ ++I VSW+PP QNG++ EY++WCLGNE+R+H+N++ G S
Sbjct: 770 GPPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARS 829
Query: 798 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSP--EDQVSLAQQISDVV 855
++ LVPG+ Y VAA+T AG GV S P +QL + + + P E LA +++ V+
Sbjct: 830 AMLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPD-LEPGLEVGAGLAVRLARVL 888
Query: 856 KQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGE 915
++PAF+AG GAAC +L+ LY RK+R L+ A SF +TP V++
Sbjct: 889 REPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTA------SFAYTPAVSFPHSEG 942
Query: 916 AVSSGGRP--GLLNISEPAAQPWLADTWPNTGNNHN--DCSISCCTAGNGNSDSNLTTYS 971
+ RP GL PA WLAD+WP+ + + + SCC + N D + Y+
Sbjct: 943 LSGASSRPPMGL----GPAPYSWLADSWPHPSRSPSAQEPRGSCCPS---NPDPDDRYYN 995
Query: 972 RPADCIANYNNQLDNKQTNLMLP-ESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQ 1030
A + L P E VY +D + + E++TF+ G +PSG
Sbjct: 996 E-----AGISLYLAQTARGTAAPGEGPVYSTIDPAGE--ELQTFHG-----GFPQHPSGD 1043
Query: 1031 PTPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRAN 1090
P+ +Q S GDSG K G+ K PVQ LN
Sbjct: 1044 LGPW--SQYAPPEWS------QGDSGAKG----GKVKLLGKPVQ-----MPSLNWP---- 1082
Query: 1091 DTVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPP 1150
+ +PP P S S G + +G+ P+ W +P
Sbjct: 1083 EALPPPPP---------------SCELSCLEGPEEELEGSSEPE-------EWCPPMPER 1120
Query: 1151 PAHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASS 1210
P S+ C V P+R + PTP
Sbjct: 1121 SHLTEPSSSG---------------GCLVTPSR-----------RETPSPTP-------- 1146
Query: 1211 PAAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPP 1262
SY QSTATLTPSP + QP P + H+ P RR P+ P P
Sbjct: 1147 ----SYGQQSTATLTPSPPDPPQP-----PTDMPHLHQMP--RRVPLGPSSP 1187
Score = 42.0 bits (97), Expect = 0.005
Identities = 61/223 (27%), Positives = 86/223 (38%), Gaps = 65/223 (29%)
Query: 1376 GLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAK----KLKHQPGH 1431
G++ AR A H S P P++ S + T P + + + +P
Sbjct: 1196 GIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKA 1255
Query: 1432 L--RRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSS 1489
L RRE DLPPPP+PPP ++ A LE+R + S++ +RS +RK
Sbjct: 1256 LPYRRENSPGDLPPPPLPPPEEEASWA-----LELR--AAGSMSSLER--ERSGERKAV- 1305
Query: 1490 YKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYC 1549
Q V + AA+R L P +E LPY
Sbjct: 1306 ----------QAVPL-----------------------AAQRVLHPD-----EEAWLPYS 1327
Query: 1550 RPTF----------PTSNNPRDPSSSSSMSSRGSG-SRQREQA 1581
RP+F T+ + SSSS SRG G SR R Q+
Sbjct: 1328 RPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQS 1370
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 237 bits (605), Expect = 6e-62
Identities = 218/858 (25%), Positives = 357/858 (41%), Gaps = 85/858 (9%)
Query: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
ED PRIV S+ +V+ GE +L C A+G P PT+ W E + D R+++ +
Sbjct: 464 EDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH-RTNQYTMS 522
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-----D 139
G+ V G + R D GVY C ARN +G A + A + V R PS +
Sbjct: 523 DGTTISHMNVTGPQIR-DGGVYRCTARNLVGSA-EYQARINV-------RGPPSIRAMRN 573
Query: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS-DAGK 198
+ G ++ C+ G+P +I W KD L D ++ G L +T +K D G+
Sbjct: 574 ITAVAGRDTLINCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGE 632
Query: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT-VRWR 257
Y+C S+ + V + P ++ ++ C +P + WR
Sbjct: 633 YLCSVLIQPQLSISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWR 691
Query: 258 KDDGELPKSRYEIRDDH-----TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
KD G++ S + + +L+I V+ G+YTC+A N L V+ PP
Sbjct: 692 KD-GQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPP 750
Query: 313 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372
FVV+P +Q G+ C G P P + W+ Y P + R +
Sbjct: 751 RFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNS 810
Query: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG- 431
L I +V D+GYY+CQ N G+ I+K+ + P +I P N T+A+ G
Sbjct: 811 SLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKI-----PAMITSHP-NTTIAIKGH 864
Query: 432 TFVLSCVATGSPVPTILWRKDGVLVS---TQDSRIKQLENG-----VLQIRYAKLGDTGR 483
L+C A G I W K ++ I +NG L+++ A GD+
Sbjct: 865 AKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVF 924
Query: 484 YTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 543
++C A GE + VQE P P + E+ +V ++ L W
Sbjct: 925 FSCHAINSYGEDRGLIQLTVQE----------------PPDPPELEIREVKARSMNLRWT 968
Query: 544 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVK--TETSAIKGLKPNAIYLFLVRAANAY 601
+ + T + IE + + ++ N+ + I L P ++Y + + N
Sbjct: 969 QRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKI 1028
Query: 602 GISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV--- 658
G S+PS+ + T++ P +D ++S SI+V W
Sbjct: 1029 GRSEPSK-ELTISTEEAAPDGPPMD---------------VTLQPVTSQSIQVTWKAPKK 1072
Query: 659 DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARPFFN 717
+ Q+ I+GY+I YR + + + E++ + V + +L+K Y + + F
Sbjct: 1073 ELQNGVIRGYQIGYRENSPG-SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1131
Query: 718 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV- 776
G S A TLE+ PS PP+ V + ++SW PP T NG+++ Y+V
Sbjct: 1132 AGTGPSSSEINATTLEDVPSQPPENVRALSITSD--VAVISWSEPPRSTLNGVLKGYRVI 1189
Query: 777 -WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL--D 833
W L + + + + + V + + YSV+V A T AG GV+S +IQ D
Sbjct: 1190 FWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKED 1249
Query: 834 AHGNPVSPEDQVSLAQQI 851
G P + S A +
Sbjct: 1250 VPGPPAGIKAVPSSASSV 1267
Score = 144 bits (362), Expect = 9e-34
Identities = 145/488 (29%), Positives = 205/488 (42%), Gaps = 68/488 (13%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
P I++ V G L C A G P P I W K G LP+ S
Sbjct: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--------------LPADSR 331
Query: 89 FFLRIVHGRKS---RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
+ RI S D G Y+C N G A + + + L P + +G
Sbjct: 332 WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGIG 389
Query: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG---GKLMITYTRKSDAGKYVCV 202
++ C G PE TI W ++ + L DE I+IRG L+IT +KS +G Y C
Sbjct: 390 STVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF 447
Query: 203 GTNMVGERESEVAE---LTVLE--RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
T R+++ A+ + LE P V S V + C A+G P PTV W
Sbjct: 448 AT-----RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
Query: 258 KD------DGELPKSRYEIRDDHTLKIRKVTA---GDMGSYTCVAENMVGKAEASATLTV 308
D DG ++Y + D T+ VT D G Y C A N+VG AE A + V
Sbjct: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
Query: 309 QEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 368
+ PP + R+ GR C G P +I W ++ LL + R V
Sbjct: 563 RGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLL-----PDNHRQVV 613
Query: 369 SQTGDLTITNVQRS-DVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQ 425
+ G L +T+VQ+ D G Y+C S++ + L ++ +A + PP+I+ P
Sbjct: 614 FENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKVPPLIQ--PFEF 664
Query: 426 TVAVDGTFV-LSCVATGSPVP-TILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDT 481
A G + + CV + +P I WRKDG V++S I+ E LQI L
Sbjct: 665 PPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHN 724
Query: 482 GRYTCIAS 489
G YTCIAS
Sbjct: 725 GNYTCIAS 732
Score = 133 bits (334), Expect = 2e-30
Identities = 226/993 (22%), Positives = 366/993 (36%), Gaps = 131/993 (13%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
P + P L G L+C G P TI WY+ E V D+ + + S
Sbjct: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDE------AISIRGLS 427
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD---FRQNPSDVMVAV 144
L I +KS G Y C A A + L D + S+ +V
Sbjct: 428 NETLLITSAQKSH--SGAYQCFATRKAQTA----QDFAIIALEDGTPRIVSSFSEKVVNP 481
Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGG----KLMITYTRKSDA 196
GE + C +G P PT++W D P+ + + T+ G + +T + D
Sbjct: 482 GEQFSLMC-AAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDG 540
Query: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
G Y C N+VG E + A + V PS ++ N+ C G P +++W
Sbjct: 541 GVYRCTARNLVGSAEYQ-ARINVRGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKW 598
Query: 257 RKDDGELPKS-RYEIRDDHTLKIRKVTAG-DMGSYTC-VAENMVGKAEASATLTVQEPPH 313
KD LP + R + ++ TLK+ V G D G Y C V S + V+ PP
Sbjct: 599 YKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPP- 657
Query: 314 FVVKPRD-QVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
+++P + ++G+ + C + P I WR++G + S +S S
Sbjct: 658 -LIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS---- 712
Query: 372 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 431
L I++V G Y C N A ++ + L V R PP P NQ
Sbjct: 713 -SLQISSVSLKHNGNYTCIASNAAATVSRERQLIV------RVPPRFVVQPNNQDGIYGK 765
Query: 432 TFVLSCVATGSPVPTILWRKDGVLVSTQD-------SRIKQLENGVLQIRYAKLGDTGRY 484
VL+C G P P ++W+ + Q RI+ L N L IR+ D G Y
Sbjct: 766 AGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYY 825
Query: 485 TCIASTPSG-EATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 542
C AS G + + S ++ V+ +P P I + T + + W
Sbjct: 826 LCQASNGVGTDISKSMFLTVK---IPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRW 882
Query: 543 QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYG 602
+ ++ P + ++ A+ + V +K +K F A N+YG
Sbjct: 883 EKG-DTVIDPDR--VMRYAIATKDNGDEVVSTLK-----LKPADRGDSVFFSCHAINSYG 934
Query: 603 ISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD-QQ 661
+G+ VQ L + + + S+ + WT
Sbjct: 935 ------------------EDRGLIQLTVQEPPDPPELEIRE---VKARSMNLRWTQRFDG 973
Query: 662 SQYIQGYKILYRPSGANHGESDWLVFEVRT----PAKNSVVIPDLRKGVNYEIKARPFFN 717
+ I G+ I Y+ +SD F+ T P N I DL Y I+ F
Sbjct: 974 NSIITGFDIEYK------NKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNK 1027
Query: 718 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 777
+ S+ T E AP PP VT+ +I V+W+ P ++ QNG+++ Y++
Sbjct: 1028 IGRSEPSKELTISTEEAAPDGPPMDVTL--QPVTSQSIQVTWKAPKKELQNGVIRGYQIG 1085
Query: 778 ----CLGNETRYHI-NKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 832
G+ +Y I G + + L +Y V V A AG+G S +
Sbjct: 1086 YRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTG-PSSSEINAT 1144
Query: 833 DAHGNPVSPEDQVSLAQQISDVV----KQPAFIAGIGAACWIILMVFSIWLYRHRKKRNG 888
P P + V SDV +P G ++ +S+++ +
Sbjct: 1145 TLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQN 1204
Query: 889 LTST-----YAGIRKVPSFTFTPTVTYQRGGEAVSS------------GGRPGLLNISEP 931
+T+T G+ K +++ + Y + G+ V S G G+ +
Sbjct: 1205 ITTTRERVELRGMEKFTNYS-VQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAVPSS 1263
Query: 932 AAQ---PWLADTWPNTGNNHNDCSISCCTAGNG 961
A+ WL T PN +I C + G+G
Sbjct: 1264 ASSVVVSWLPPTKPN--GVIRKYTIFCSSPGSG 1294
Score = 132 bits (331), Expect = 4e-30
Identities = 186/833 (22%), Positives = 322/833 (38%), Gaps = 112/833 (13%)
Query: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL-PSGSLFFLRIVHGRKSRP 101
G +NC+ G P +I+WYK + P +HR ++ +G+L + G
Sbjct: 579 GRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGTLKLTDVQKGM---- 628
Query: 102 DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 159
DEG Y+C + + L + S + +++V L F P+ ++G+ + C G
Sbjct: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA----SIGQLLYIPCVVSSGDM 684
Query: 160 EPTISWKKDGSPLDDKDERITIRGGKLM----ITYTRKSDAGKYVCVGTNMVGERESEVA 215
I+W+KDG + +TI + M I+ G Y C+ +N E
Sbjct: 685 PIRITWRKDGQVIIS-GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-R 742
Query: 216 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY------- 268
+L V P FV +P+N + C G P P V W+ G +Y
Sbjct: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
Query: 269 --EIRDDHTLKIRKVTAGDMGSYTCVAENMVGK-AEASATLTVQEPPHFVVKPRDQVVAL 325
+I + +L IR V D+G Y C A N VG S LTV+ P P +
Sbjct: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK 862
Query: 326 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS--QTGDLTITNVQ--- 380
G C A G I W + + P R++++ GD ++ ++
Sbjct: 863 GHAKELNCTARGERPIIIRWEKGDT------VIDPDRVMRYAIATKDNGDEVVSTLKLKP 916
Query: 381 --RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV------IRQGPVNQTVAVDGT 432
R D ++ C +N G + +++T PP + R + T DG
Sbjct: 917 ADRGDSVFFSCHAINSYGE--DRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGN 974
Query: 433 FVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCI 487
+++ + W + + + I L V IR GR
Sbjct: 975 SIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR---- 1030
Query: 488 ASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP--- 544
S PS E T S E P PP D L P V+ ++ ++W+
Sbjct: 1031 -SEPSKELTIST-----EEAAPDGPPM--DVTLQP----------VTSQSIQVTWKAPKK 1072
Query: 545 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK----TETSAIKGLKPNAIYLFLVRAANA 600
L +G Y I ++ GS+ Q +K +E + LK A Y +V+A N
Sbjct: 1073 ELQNGVI-RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1131
Query: 601 YGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ 660
G S + +DV P+ + + + AV+ P + + +
Sbjct: 1132 AGTGPSSSEINATTLEDV-PSQPPENVRALSITSDVAVISWSEPPRSTLNGV-------- 1182
Query: 661 QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQ 720
++GY++++ + + + +W + T + V + + K NY ++ +
Sbjct: 1183 ----LKGYRVIF---WSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGD 1235
Query: 721 GADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLG 780
G S + + +T E+ P PP G+ + + ++++VSW PP + NG++++Y ++C
Sbjct: 1236 GVRSSVLYIQTKEDVPG-PPAGIKAVPS--SASSVVVSWLPPTKP--NGVIRKYTIFCSS 1290
Query: 781 NETRYHINKTVDGSTFSVV--IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 831
+ + S + I L G +Y + VAA T AG G SE I+
Sbjct: 1291 PGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE 1343
Score = 131 bits (330), Expect = 5e-30
Identities = 133/477 (27%), Positives = 193/477 (40%), Gaps = 42/477 (8%)
Query: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHR----MLLPSGSLFFLRIVHGRKSRPDEG 104
C A G P+ + WY G+ + H L P F +H +
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH-------DN 159
Query: 105 VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE--PT 162
Y C A N G+ S N ++ A+ R+ + D G AV +C P E
Sbjct: 160 DYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Query: 163 ISWKKDG-SPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNMV-GE-RESEVAELT 218
+SW+KD S + + IT GG L I+ +K DA Y C+ + GE R+S A L+
Sbjct: 219 VSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
Query: 219 VLER----PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH 274
V + P+ + + V + E C A G P+P +RW KD LP +
Sbjct: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
Query: 275 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 334
L I + D G+Y C N G AEA+ L V +P H + P+ +G TV C
Sbjct: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCA 397
Query: 335 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 394
TG+P+ I W R L P ++ S +S L IT+ Q+S G Y C
Sbjct: 398 LTGSPEFTIRWYRNTELVL-----PDEAISIRGLSNE-TLLITSAQKSHSGAYQCFATRK 451
Query: 395 AGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR-KDG 453
A + A + + D P I + V F L C A G+P PT+ W D
Sbjct: 452 AQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDE 506
Query: 454 VLVSTQDSRIKQ--LENGV----LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
+V R Q + +G + + ++ D G Y C A G A + A I V+
Sbjct: 507 PIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
Score = 102 bits (253), Expect = 4e-21
Identities = 93/324 (28%), Positives = 140/324 (43%), Gaps = 29/324 (8%)
Query: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKC---EARGDPVPTVR 255
Y C N G+ S + + R + R + + A FKC + + V V
Sbjct: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Query: 256 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGD-MGSYTCVAENMVG---KAEASATLTVQE 310
W KD + P+ R+ I L I V D + +Y C+ ++ + A L+V +
Sbjct: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
Query: 311 PPHFVVKPRD----QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 366
P + D Q V G TV C A+G P PAI W ++G +P + SR+
Sbjct: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG--------RPLPADSRW 332
Query: 367 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 426
+ TG LTI++++ D G YIC+ N GS L V D P + P
Sbjct: 333 TKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID------PLHVTLTPKKLK 385
Query: 427 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYT 485
+ T +LSC TGSP TI W ++ LV ++ I+ L N L I A+ +G Y
Sbjct: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
Query: 486 CIASTPSGEATWSAYIEVQEFGVP 509
C A+ + A A I +++ G P
Sbjct: 446 CFATRKAQTAQDFAIIALED-GTP 468
Score = 69.3 bits (168), Expect = 3e-11
Identities = 76/310 (24%), Positives = 121/310 (39%), Gaps = 44/310 (14%)
Query: 435 LSCVATGSPVPTILWRKDG----VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 490
L C + G P P + W KD + VS R+ NG L +R K D+G YTC A+
Sbjct: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCTATN 1427
Query: 491 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 550
G T + VQ VP PR T V+ S +++TL+W P N G+
Sbjct: 1428 TGGFDTIIVNLLVQ---VPPDQPRLT-------------VSKTSASSITLTWIPGDNGGS 1471
Query: 551 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 610
+ ++++ +S + W+ V + + + LK Y + A N+ G S+I
Sbjct: 1472 SIRGFVLQ-YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEII 1530
Query: 611 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 670
+ KT P+ H +A L+L W + I +
Sbjct: 1531 E-AKTHGREPSFSKDQHLFTHINSTHARLNLQG------------W--NNGGCPITAIVL 1575
Query: 671 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 730
YRP G W +R + V + +LR+ YE++ R N + +FA
Sbjct: 1576 EYRPKGT------WAWQGLRANSSGEVFLTELREATWYELRMRA-CNSAGCGNETAQFAT 1628
Query: 731 TLEEAPSAPP 740
+ + PP
Sbjct: 1629 LDYDGSTIPP 1638
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/74 (43%), Positives = 36/74 (48%), Gaps = 5/74 (6%)
Query: 244 CEARGDPVPTVRWRKD--DGELPKSRYEIRDDHT---LKIRKVTAGDMGSYTCVAENMVG 298
C + GDP P V+W KD D +P S R HT L +R V A D G YTC A N G
Sbjct: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
Query: 299 KAEASATLTVQEPP 312
L VQ PP
Sbjct: 1431 FDTIIVNLLVQVPP 1444
Score = 45.8 bits (107), Expect = 3e-04
Identities = 72/359 (20%), Positives = 127/359 (35%), Gaps = 51/359 (14%)
Query: 261 GELPKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
G+ S YE + +I + G A G+ +S +T++ K
Sbjct: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAG----KAP 1349
Query: 320 DQVVALGRTVT--------FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
++++ G TVT C + G+P PA+ W ++ + + P +
Sbjct: 1350 AKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI----PVSMDGHRLIHTN 1405
Query: 372 GDLTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 429
G L + V+ D GYY C N G +II ++V D+P + + +
Sbjct: 1406 GTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSITLT 1462
Query: 430 ------DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGR 483
G+ + V S + W+ V +S+ + K + K G +
Sbjct: 1463 WIPGDNGGSSIRGFVLQYSVDNSEEWK--DVFISSSERSFK--------LDSLKCGTWYK 1512
Query: 484 YTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 543
A G S IE + G +P D +L T ++ L+ Q
Sbjct: 1513 VKLAAKNSVGSGRISEIIEAKTHG--REPSFSKDQHLF---------THINSTHARLNLQ 1561
Query: 544 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYG 602
N+G P + I+ + +WQ + N E + L+ Y +RA N+ G
Sbjct: 1562 -GWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEV-FLTELREATWYELRMRACNSAG 1618
Score = 37.0 bits (84), Expect = 0.15
Identities = 34/157 (21%), Positives = 58/157 (36%), Gaps = 14/157 (8%)
Query: 157 GHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
G P P + W KD P+ R+ G L++ + D+G Y C TN G ++
Sbjct: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN-TGGFDT 1433
Query: 213 EVAELTVLERPSFVK------RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
+ L V P + S++ +T RG +++ D+ E K
Sbjct: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGF---VLQYSVDNSEEWKD 1490
Query: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 303
+ + + K+ + G A+N VG S
Sbjct: 1491 VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS 1527
Score = 34.7 bits (78), Expect = 0.77
Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLP 84
P +I+ + + L C + G P P ++W K E D P S HR++
Sbjct: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE----DSAIPVSMDGHRLIHT 1404
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARN 112
+G+L LR V D G Y C A N
Sbjct: 1405 NGTL-LLRAVKAE----DSGYYTCTATN 1427
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 229 bits (585), Expect = 1e-59
Identities = 261/981 (26%), Positives = 401/981 (40%), Gaps = 143/981 (14%)
Query: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDP----RSHR 80
ED P+I+ S+ +VS EP +L C +G P PTI W T DDP SHR
Sbjct: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW--------TLDDDPILKGGSHR 454
Query: 81 ---MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
M+ G++ + + R D GVY C A N G V + A + V R P
Sbjct: 455 ISQMITSEGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRP 509
Query: 138 SDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKS- 194
+ A+ G + C+ G+P +I W K+ + L ++ G L ++ +K
Sbjct: 510 MKNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV 568
Query: 195 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-T 253
D G+Y C S+ +TV + P F++ ++ C +P T
Sbjct: 569 DEGEYTCNVLVQPQLSTSQSVHVTV-KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
Query: 254 VRWRKDDGELPKSRYEIRDD----HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
+ W+KD +P S D+ +L+I ++ G+YTC+A N E + L V+
Sbjct: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
Query: 310 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 369
PP FVV+PRDQ G+ V C A G P P I W+ + +QP + R V
Sbjct: 688 VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP-QFQPIALNGRIQVL 746
Query: 370 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKA-YLEVTDVIADRPPPVIRQGPVNQTVA 428
G L I +V D GYY+C+ N G+ ++K+ YL V + P +I P N T+A
Sbjct: 747 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV------KIPAMITSYP-NTTLA 799
Query: 429 VDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENG-----VLQIRYAKLGD 480
G +SC A G + W K+ +++ + +R + E G LQI D
Sbjct: 800 TQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED 859
Query: 481 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 540
+G ++C A GE + VQE P P + E+ DV T+TL
Sbjct: 860 SGFFSCHAINSYGEDRGIIQLTVQE----------------PPDPPEIEIKDVKARTITL 903
Query: 541 SWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLVRAA 598
W + + T Y IE + + S+ +T + + ++ I + P++ Y + A
Sbjct: 904 RWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAK 963
Query: 599 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 658
N G S+PS + + P + +HL +SS SI V W
Sbjct: 964 NRIGKSEPSN-ELTITADEAAPDGPPQE------------VHLE---PISSQSIRVTWKA 1007
Query: 659 DQ---QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARP 714
+ Q+ I+GY+I YR G + + V T + V + +L K Y + +
Sbjct: 1008 PKKHLQNGIIRGYQIGYREYSTG-GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQA 1066
Query: 715 FFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 774
G S+ TLE+ PS PP+ V + +I +SW ++ NG++Q +
Sbjct: 1067 CNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT--SPESISISWSTLSKEALNGILQGF 1124
Query: 775 KV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 832
+V W + K + + S+ + L YS++V A T AG GV+SE F +
Sbjct: 1125 RVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRT 1184
Query: 833 --DAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLT 890
D G P AG+ AA MVF WL K NG+
Sbjct: 1185 KEDVPGPP-----------------------AGVKAAAASASMVFVSWL--PPLKLNGI- 1218
Query: 891 STYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQP-WLADTWPNTGNN-- 947
IRK F P T ISE A P + PN N
Sbjct: 1219 -----IRKYTVFCSHPYPTV-----------------ISEFEASPDSFSYRIPNLSRNRQ 1256
Query: 948 HNDCSISCCTAGNGNSDSNLT 968
++ ++ +AG GNS +T
Sbjct: 1257 YSVWVVAVTSAGRGNSSEIIT 1277
Score = 127 bits (319), Expect = 9e-29
Identities = 193/853 (22%), Positives = 335/853 (39%), Gaps = 105/853 (12%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
P + P + S G +L+C G + WY+ GE + K+ +
Sbjct: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVMVAV 144
+ ++ + D G Y C R + +S ++V +L D S+ +V+
Sbjct: 365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQV-VLEDGTPKIISAFSEKVVSP 420
Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL-----DDKDERITIRG---GKLMITYTRKSDA 196
EP + C +G P PTI+W D P+ + IT G L I+ ++ D
Sbjct: 421 AEPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
Query: 197 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 256
G Y C N G + A + V P+ ++ N+ C G P +++W
Sbjct: 480 GVYRCTANNSAGVVLYQ-ARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKW 537
Query: 257 RKDDGELPKSRYEI--RDDHTLKIRKVTAG-DMGSYTC-VAENMVGKAEASATLTVQEPP 312
K+ LP + ++ ++ TLK+ V D G YTC V S +TV+ PP
Sbjct: 538 YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPP 597
Query: 313 HFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVSQ- 370
F+ ++G+ V C P I W+++G +P S ++
Sbjct: 598 -FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG--------RPIPGSLGVTIDNI 648
Query: 371 --TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 428
T L I+N+ G Y C N A ++ ++ L V R PP P +Q
Sbjct: 649 DFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQDGI 702
Query: 429 VDGTFVLSCVATGSPVPTILWR--KDGVLVSTQ----DSRIKQLENGVLQIRYAKLGDTG 482
+L+C A G PVPTI+W+ K + Q + RI+ L NG L I++ D+G
Sbjct: 703 YGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSG 762
Query: 483 RYTCIASTPSG-EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNTVT 539
Y C S G + + S Y+ V+ + P T + + K E+ T +
Sbjct: 763 YYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTT----LATQGQKKEMSCTAHGEKPII 818
Query: 540 LSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAAN 599
+ W+ II S + V E V + + ++ ++ + F A N
Sbjct: 819 VRWEKE--------DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-FSCHAIN 869
Query: 600 AYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD 659
+YG +G+ VQ + + + + + +I + WT+
Sbjct: 870 SYG------------------EDRGIIQLTVQEPPDPPEIEIKD---VKARTITLRWTMG 908
Query: 660 -QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNE 718
+ I GY I + + ++ +S +V +P NS I D+ Y I+ N
Sbjct: 909 FDGNSPITGYDIECK-NKSDSWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYA-KNR 965
Query: 719 FQGADSEIKFAKTLEE-APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV- 776
++ + T +E AP PPQ V + + +I V+W+ P + QNG+++ Y++
Sbjct: 966 IGKSEPSNELTITADEAAPDGPPQEVHLEPI--SSQSIRVTWKAPKKHLQNGIIRGYQIG 1023
Query: 777 ---WCLGNETRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 832
+ G +++ I+ G + + L +Y + V A AG+G S+ + I
Sbjct: 1024 YREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ-EIITT 1082
Query: 833 DAHGNPVSPEDQV 845
P P + V
Sbjct: 1083 TLEDVPSYPPENV 1095
Score = 122 bits (307), Expect = 2e-27
Identities = 129/487 (26%), Positives = 194/487 (39%), Gaps = 62/487 (12%)
Query: 50 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLPSGSL--------FFLRIVHGRKSR 100
C A G P T+ WY GE + D R + P+G+L F ++H
Sbjct: 46 CPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPPSSFSTLIH----- 96
Query: 101 PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE 160
+ Y C A N G+ S + ++ A+LR+ + D G AV +C P
Sbjct: 97 --DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEA 153
Query: 161 --PTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNM-VGE-RESEVA 215
+SW+KD L + G L I + D Y C+ + GE R+S A
Sbjct: 154 YITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSA 213
Query: 216 ELTVLERPSFVKRPSNLAVTVDDS-----------AEFKCEARGDPVPTVRWRKDDGELP 264
L FV P+N A ++ D E C+A G P P RW KD+ L
Sbjct: 214 RL-------FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
Query: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA 324
S + L I + D GSY C N G A+ L V++P + PR +
Sbjct: 267 LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSS 326
Query: 325 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV 384
+G V+ C TG + W R G P + R + +L + ++ +SD
Sbjct: 327 VGSQVSLSCSVTGTEDQELSWYRNG------EILNPGKNVRITGINHENLIMDHMVKSDG 380
Query: 385 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPV 444
G Y C + + Y++V V+ D P +I + V+ L C G+P+
Sbjct: 381 GAYQCFVRK--DKLSAQDYVQV--VLEDGTPKII-SAFSEKVVSPAEPVSLMCNVKGTPL 435
Query: 445 PTILWR-KDGVLVSTQDSRIKQL---ENGV---LQIRYAKLGDTGRYTCIASTPSGEATW 497
PTI W D ++ RI Q+ E V L I +++ D G Y C A+ +G +
Sbjct: 436 PTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLY 495
Query: 498 SAYIEVQ 504
A I V+
Sbjct: 496 QARINVR 502
Score = 107 bits (268), Expect = 7e-23
Identities = 127/490 (25%), Positives = 188/490 (38%), Gaps = 43/490 (8%)
Query: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
G+ L CKA G P P W K +E ++ LL I + R S D
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLL---------IENIRPS--D 287
Query: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
G YVC N G A L+ +P V +VG + C G +
Sbjct: 288 SGSYVCEVSNRYGTAKVIGRLYVKQPLKATI--SPRKVKSSVGSQVSLSCS-VTGTEDQE 344
Query: 163 ISWKKDGSPLD-DKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
+SW ++G L+ K+ RIT I L++ + KSD G Y C + V +
Sbjct: 345 LSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLED 404
Query: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDDHT---- 275
P + S V+ + C +G P+PT+ W DD + K + I T
Sbjct: 405 GTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGN 464
Query: 276 ----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL-GRTVT 330
L I D G Y C A N G A + V+ P ++P + A+ GR
Sbjct: 465 VVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS--IRPMKNITAIAGRDTY 522
Query: 331 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGYYIC 389
C G P +I W + + NLL P + + + G L +++VQ+ D G Y C
Sbjct: 523 IHCRVIGYPYYSIKWYK--NSNLL-----PFNHRQVAFENNGTLKLSDVQKEVDEGEYTC 575
Query: 390 QTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 449
L V + T + VT + PP I+ + F+ V +G TI W
Sbjct: 576 NVL-VQPQLSTSQSVHVTVKV----PPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITW 630
Query: 450 RKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFG 507
+KDG + + I ++ L+I L G YTCIA + + + V+
Sbjct: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690
Query: 508 VPVQPPRPTD 517
V PR D
Sbjct: 691 KFVVQPRDQD 700
Score = 82.4 bits (202), Expect = 3e-15
Identities = 79/319 (24%), Positives = 134/319 (42%), Gaps = 41/319 (12%)
Query: 434 VLSCVATGSPVPTILWRKDG---VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 490
VL C A G P P + W KD + T D R NG IR K D+G Y+CIA+
Sbjct: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
Query: 491 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 550
G ++VQ VP PR T V+ + +++TLSW P N G+
Sbjct: 1364 NWGSDEIILNLQVQ---VPPDQPRLT-------------VSKTTSSSITLSWLPGDNGGS 1407
Query: 551 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 610
+ YI++ +S + W + + + ++ LK Y F + A N G P +IS
Sbjct: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
Query: 611 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 670
+ ++ + + Q +++ + + L+ + W + I + +
Sbjct: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGW--NDGGCPITSFTL 1511
Query: 671 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 730
YRP G + W + RT S ++ DL++ YE++ R N A+ + FA
Sbjct: 1512 EYRP----FGTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR-VCNSAGCAEKQANFAT 1565
Query: 731 TLEEAPSAPPQGVTVSKND 749
+ + PP +V +N+
Sbjct: 1566 LNYDGSTIPPLIKSVVQNE 1584
Score = 53.5 bits (127), Expect = 2e-06
Identities = 30/74 (40%), Positives = 36/74 (48%), Gaps = 5/74 (6%)
Query: 244 CEARGDPVPTVRWRKDDGELPK-----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
C+A GDP P V+W KD P R I + + IR V A D G Y+C+A N G
Sbjct: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
Query: 299 KAEASATLTVQEPP 312
E L VQ PP
Sbjct: 1367 SDEIILNLQVQVPP 1380
Score = 47.4 bits (111), Expect = 1e-04
Identities = 81/387 (20%), Positives = 144/387 (37%), Gaps = 68/387 (17%)
Query: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVT- 330
D + +I ++ S VA G+ +S +TV+ + K +++ TVT
Sbjct: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEP----LAKAPARILTFSGTVTT 1297
Query: 331 -------FQCEATGNPQPAIFWRRE--GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 381
C+A G+P PA+ W ++ G+ +L+ R S+ G I V+
Sbjct: 1298 PWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKA 1351
Query: 382 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD-------GTFV 434
D GYY C N GS L+V V D+P + + + ++ + G+ +
Sbjct: 1352 EDSGYYSCIANNNWGSDEIILNLQV-QVPPDQPRLTVSK-TTSSSITLSWLPGDNGGSSI 1409
Query: 435 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 494
+ S + W + S + R++ L K G ++T A G
Sbjct: 1410 RGYILQYSEDNSEQWGSFPISPSERSYRLENL----------KCGTWYKFTLTAQNGVGP 1459
Query: 495 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-T 553
S IE + G +P + L S T V N + W N G P T
Sbjct: 1460 GRISEIIEAKTLG--KEPQFSKEQELFASI----NTTRVRLNLI--GW----NDGGCPIT 1507
Query: 554 SYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD-------- 605
S+ +E + + W T +++ + L+ Y +R N+ G ++
Sbjct: 1508 SFTLE-YRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATL 1566
Query: 606 -------PSQISDPVKTQDVLPTSQGV 625
P I V+ ++ L T++G+
Sbjct: 1567 NYDGSTIPPLIKSVVQNEEGLTTNEGL 1593
Score = 35.0 bits (79), Expect = 0.59
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--GGERVETDKDDPRSHRMLLPS 85
P RI+ + + L CKA G P+P ++W K G D RS + +
Sbjct: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS---IFSN 1341
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
GS F +R V D G Y C+A N G
Sbjct: 1342 GS-FIIRTVKAE----DSGYYSCIANNNWG 1366
Score = 33.5 bits (75), Expect = 1.7
Identities = 38/171 (22%), Positives = 67/171 (39%), Gaps = 17/171 (9%)
Query: 157 GHPEPTISWKKD--GSP--LDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
G P P + W KD G+P + R G +I + D+G Y C+ N G E
Sbjct: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
Query: 213 EVAELTVLERPS----FVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRKDDGELPKS 266
+ L V P V + ++ ++T+ RG +++ +D+ E S
Sbjct: 1371 -ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRG---YILQYSEDNSEQWGS 1426
Query: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL---TVQEPPHF 314
+ + ++ + G +T A+N VG S + T+ + P F
Sbjct: 1427 FPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQF 1477
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 223 bits (568), Expect = 1e-57
Identities = 224/825 (27%), Positives = 342/825 (41%), Gaps = 100/825 (12%)
Query: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
P D + +G LNC A P+P IEW K G + DD R LLP GSLF +V
Sbjct: 59 PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNVV 115
Query: 95 HGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153
H + ++PDEG Y CVA LG +S A L VA L F P V G A++ C+
Sbjct: 116 HSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNCE 174
Query: 154 PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 213
P + W+++ PL D I + G L+I+ + D G Y CV + + S+
Sbjct: 175 V-NADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSD 233
Query: 214 VAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP--- 264
EL VL P F+K+PS L + C A G P PT++W K++ L
Sbjct: 234 EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES 293
Query: 265 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA 324
R + +L+I VT D G+Y C+A+N EA A LTVQ P F+ +P +
Sbjct: 294 SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAH 353
Query: 325 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV 384
+ F+CE TG P P + W + G + Y F + + +L + + +SD
Sbjct: 354 ESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDY--------FKIVKEHNLQVLGLVKSDE 405
Query: 385 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSP 443
G+Y C N G+ A L + + P + P + ++ T F+ T +
Sbjct: 406 GFYQCIAENDVGNAQAGAQLIILEHAPATTGP-LPSAPRDVVASLVSTRFIKLTWRTPAS 464
Query: 444 VP-------TILWRKDGVLVSTQDSRIKQLEN-GVLQIRYAKLGDTGRY--TCIASTPSG 493
P ++ + K+G+ R++ + G +Q+ L Y +A G
Sbjct: 465 DPHGDNLTYSVFYTKEGI----ARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 520
Query: 494 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPT 553
SA + V E VQ P P PNL A S ++T++W+ ++
Sbjct: 521 SGESSAPLRV-ETQPEVQLPGPA-PNLRAYA--------ASPTSITVTWETPVSGNGEIQ 570
Query: 554 SYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY--GISDPSQISD 611
+Y + + +V + + I GLK Y F V A N + G+S P
Sbjct: 571 NYKLYYMEKGTDKEQDV---DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDV--- 624
Query: 612 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW---TVDQQSQYIQGY 668
V+T +P++ N L + N S SI +HW Q+ I GY
Sbjct: 625 AVRTLSDVPSAAP----------QNLSLEVRN-----SKSIMIHWQPPAPATQNGQITGY 669
Query: 669 KILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKF 728
KI YR + ++ LV + + S +I L +G Y + G ++
Sbjct: 670 KIRYRKASRKSDVTETLV----SGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLS 725
Query: 729 AKTLE---------EAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV-WC 778
A+T E E PS+ V T+I+VSW PP + QN +V+ Y + +
Sbjct: 726 AETFESDLDETRVPEVPSSLHVRPLV-------TSIVVSWTPP--ENQNIVVRGYAIGYG 776
Query: 779 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 823
+G+ I VD I L P Y + + A G G+
Sbjct: 777 IGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819
Score = 147 bits (371), Expect = 8e-35
Identities = 220/889 (24%), Positives = 344/889 (38%), Gaps = 141/889 (15%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
PR P V G A LNC+ P + W + + + D + LPSG L
Sbjct: 152 PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-----DRVIKLPSGML 206
Query: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVM 141
G D G+Y CV + G ++ +E+ +L D F + PS ++
Sbjct: 207 VISNATEG-----DGGLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLV 259
Query: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKY 199
+G+ V+ C G P PTI W K+ LD + ER + + GG L I+ + DAG Y
Sbjct: 260 RVIGQDVVLPC-VASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTY 318
Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
C+ N E++ AELTV +P F+K+P+N+ F+CE G P PTV+W K+
Sbjct: 319 FCIADNGNETIEAQ-AELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN 377
Query: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV-- 316
D +P ++I +H L++ + D G Y C+AEN VG A+A A L + E
Sbjct: 378 GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
Query: 317 ---KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS----QNLLFS-YQPPQSSSRFSV 368
PRD V +L T + + WR S NL +S + + +R V
Sbjct: 438 LPSAPRDVVASLVSTRFIK----------LTWRTPASDPHGDNLTYSVFYTKEGIARERV 487
Query: 369 SQTG-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 423
T +TI N+ + V + N GS + A L V + P V GP
Sbjct: 488 ENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV-----ETQPEVQLPGPA 542
Query: 424 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG-DTG 482
L A T+ W T S +++N ++ Y + G D
Sbjct: 543 PN---------LRAYAASPTSITVTW-------ETPVSGNGEIQN--YKLYYMEKGTDKE 584
Query: 483 RYTCIAS---TPSGEATWSAY----IEVQEFGVPVQPPRPTDPNL--IPS-APSKPEVTD 532
+ ++S T +G ++ Y + + G V P L +PS AP +
Sbjct: 585 QDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEV 644
Query: 533 VSRNTVTLSWQP--NLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET---SAIKGLKP 587
+ ++ + WQP T Y I + S V E + + T I+GL
Sbjct: 645 RNSKSIMIHWQPPAPATQNGQITGYKIR---YRKASRKSDVTETLVSGTQLSQLIEGLDR 701
Query: 588 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 647
Y F V A I+ +D + + +D +V + LH+ P V
Sbjct: 702 GTEYNFRVAALT---INGTGPATDWLSAETF---ESDLDETRVPEVPSS--LHV-RPLV- 751
Query: 648 SSSSIEVHWT-VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGV 706
+SI V WT + Q+ ++GY I Y G+ H ++ + ++ R I +L
Sbjct: 752 --TSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQR-----YYTIENLDPSS 803
Query: 707 NYEIKARPFFNEFQGA-------------DSEI-------KFAKTLEEAPSAPPQGVTVS 746
+Y I + F N +G SE+ + + P PP GV S
Sbjct: 804 HYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQAS 863
Query: 747 KNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPG 806
+ I + P+ + + Y V N K + +T S ++ L P
Sbjct: 864 ILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPN 923
Query: 807 IRYSVEVAASTGAGSGVKSEPQFIQLDAHGN-----PVSPEDQVSLAQQ 850
Y V + G S S + AHG P SP V++ +
Sbjct: 924 TLYEFSVMVTKGRRSSTWS------MTAHGTTFELVPTSPPKDVTVVSK 966
Score = 122 bits (305), Expect = 4e-27
Identities = 189/864 (21%), Positives = 329/864 (38%), Gaps = 98/864 (11%)
Query: 32 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 91
++ PS L+ G+ L C A G PTPTI+W K E ++T+ + +LL GSL
Sbjct: 252 LKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSE---RLVLLAGGSLEIS 308
Query: 92 RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 151
+ + D G Y C+A N E + A L V + +F + P+++ V E
Sbjct: 309 DV-----TEDDAGTYFCIADNG-NETIEAQAELTVQA-QPEFLKQPTNIYAHESMDIVFE 361
Query: 152 CQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
C+ G P PT+ W K+G + D ++ L + KSD G Y C+ N VG +
Sbjct: 362 CEVT-GKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420
Query: 212 SEVAELTVLERPSFV-----KRPSNLAVTVDDSAEFKCEAR-------GDPVPTVRWRKD 259
+ A+L +LE P ++ ++ + K R GD + +
Sbjct: 421 AG-AQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTK 479
Query: 260 DGELPKSRYEIRD---DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV 316
+G + + R E + + I+ + + + +A+N G E+SA L V+ P +
Sbjct: 480 EG-IARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQL 538
Query: 317 K-PRDQVVALGR-----TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 370
P + A TVT++ +GN + QN Y + V
Sbjct: 539 PGPAPNLRAYAASPTSITVTWETPVSGNGE---------IQNYKLYYMEKGTDKEQDVDV 589
Query: 371 TG-DLTITNVQRSDVGYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVIRQGPVNQT 426
+ TI +++ + N G ++ A ++DV + P + + +++
Sbjct: 590 SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKS 649
Query: 427 VAVDGTFVLSCVATGSPVP-TILWRK-----DGVLVSTQDSRIKQLENGVLQIRYAKLGD 480
+ + G I +RK D +++ QL G+ + G
Sbjct: 650 IMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDR------GT 703
Query: 481 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 540
+ A T +G + ++ + F + R +P PS V + ++ +
Sbjct: 704 EYNFRVAALTINGTGPATDWLSAETFESDLDETR------VPEVPSSLHVRPLV-TSIVV 756
Query: 541 SWQPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTETSAIKGLKPNAIYLFLVRAAN 599
SW P N Y A + GS QT+ + K I+ L P++ Y+ ++A N
Sbjct: 757 SWTPPENQNIVVRGY---AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFN 813
Query: 600 AYGISDP---SQISDP-VKTQDV------LPTSQGVDHKQVQRELGNAVLHLHNPTVL-- 647
G P S ++ P T +V P + D + +G L + T+
Sbjct: 814 NVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRIT 873
Query: 648 -SSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGV 706
+ +S+ H + Y +K P+ + ++ S ++ L+
Sbjct: 874 WADNSLPKHQKITDSRYYTVRWKTNI-PANTKYKNANATTL--------SYLVTGLKPNT 924
Query: 707 NYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDT 766
YE S T E P++PP+ VTV +G I+V+WQPP E
Sbjct: 925 LYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE-- 982
Query: 767 QNGMVQEYKVWC---LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 823
NG + Y ++ + E + + V G+ + I L Y ++ A G G
Sbjct: 983 ANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGP 1042
Query: 824 KSEP-QFIQLDAHGNPVSPEDQVS 846
SE QF A + P DQ S
Sbjct: 1043 MSEAVQFRTPKADSSDKMPNDQAS 1066
Score = 97.4 bits (241), Expect = 1e-19
Identities = 147/630 (23%), Positives = 217/630 (34%), Gaps = 92/630 (14%)
Query: 225 FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIRKV 281
F+ P + S C A +P P + W+KD L R ++ D +L I V
Sbjct: 55 FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
Query: 282 TAG-----DMGSYTCVA--ENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 334
D G Y CVA E++ +A L V P F +P V G CE
Sbjct: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCE 174
Query: 335 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 394
+ P + W + + QP R +G L I+N D G Y C +
Sbjct: 175 VNADLVPFVRWEQ--------NRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG 226
Query: 395 A----GSIITKAYLEVTDVIAD-----RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 445
+ L +VI+D +P P++R + VL CVA+G P P
Sbjct: 227 GPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVR--------VIGQDVVLPCVASGLPTP 278
Query: 446 TILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
TI W K+ + T+ S R+ L G L+I D G Y CIA +G T A E+
Sbjct: 279 TIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD--NGNETIEAQAELT 336
Query: 505 EFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSH-- 562
P +PT+ S E + T T+ W N P+ Y H
Sbjct: 337 VQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN-GDMVIPSDYFKIVKEHNL 395
Query: 563 -------ASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 615
+ +Q +AEN A L ++ A A PS D V
Sbjct: 396 QVLGLVKSDEGFYQCIAENDVGNAQA-------GAQLIILEHAPATTGPLPSAPRDVV-- 446
Query: 616 QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPS 675
+++S+ I++ W + G + Y
Sbjct: 447 ----------------------------ASLVSTRFIKLTWRTPASDPH--GDNLTYSVF 476
Query: 676 GANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEA 735
G + V P + V I +L Y + G S +T E
Sbjct: 477 YTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEV 536
Query: 736 PSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGST 795
P + + T+I V+W+ P + NG +Q YK++ + T + VD S+
Sbjct: 537 -QLPGPAPNLRAYAASPTSITVTWETPV--SGNGEIQNYKLYYMEKGT--DKEQDVDVSS 591
Query: 796 FSVVIPFLVPGIRYSVEVAASTGAGSGVKS 825
S I L YS V A G GV +
Sbjct: 592 HSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 221 bits (563), Expect = 4e-57
Identities = 170/559 (30%), Positives = 244/559 (43%), Gaps = 33/559 (5%)
Query: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Q PP I P+++ V TL C+A G P P+I W K G + D++ S+R LL
Sbjct: 3799 QVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQ-NSYR-LL 3856
Query: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 143
SGSL + S D Y C N G+ L V + P+D +V
Sbjct: 3857 SSGSLVIIS-----PSVDDTATYECTVTNGAGDD-KRTVDLTVQV-PPSIADEPTDFLVT 3909
Query: 144 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDAGKYVCV 202
PAV+ C G P P+I W K+G L + + I G + I T+ + AG+Y CV
Sbjct: 3910 KHAPAVITCTAS-GVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCV 3968
Query: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
N G V L V E P +PS L V +++ CEA G P P + W+K+
Sbjct: 3969 ARNAAGSAHRHVT-LHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGIN 4027
Query: 263 LPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRD 320
+ S + + L+I + D G+Y CVA+N G A L VQ PP ++
Sbjct: 4028 VNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKE 4087
Query: 321 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
V+A+ + +T CEA G P P I W ++G + S R V +G L I VQ
Sbjct: 4088 YVIAVDKPITLSCEADGLPPPDITWHKDGRAIV--------ESIRQRVLSSGSLQIAFVQ 4139
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 440
D G+Y C NVAGS T L V PP IR + TV + +L CVA
Sbjct: 4140 PGDAGHYTCMAANVAGSSSTSTKLTV------HVPPRIRSTEGHYTVNENSQAILPCVAD 4193
Query: 441 GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 500
G P P I W+KD VL++ + G L + L D+G YTC+A+ +GE T +
Sbjct: 4194 GIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVS 4253
Query: 501 IEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNL-----NSGATPTSY 555
+ V + P N + T + +T ++ N+ +S +
Sbjct: 4254 LTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSEL 4313
Query: 556 IIEAFSHASGSSWQTVAEN 574
+IE S ++ AEN
Sbjct: 4314 VIERVSKEDSGTYVCTAEN 4332
Score = 213 bits (541), Expect = 2e-54
Identities = 146/484 (30%), Positives = 220/484 (45%), Gaps = 33/484 (6%)
Query: 28 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP I + P D+ V + TL CK++ P P I W + GER++ + R+ + S
Sbjct: 3619 PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQA------TPRVRILS 3672
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
G + L+I D Y CVA N G+ + + + + P +++ +
Sbjct: 3673 GGRY-LQI--NNADLGDTANYTCVASNIAGKTTRE--FILTVNVPPNIKGGPQSLVILLN 3727
Query: 146 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDAGKYVCVGT 204
+ V+EC G P P I+W+KDG+ L R +I G L I +D G+Y+C+ T
Sbjct: 3728 KSTVLECIA-EGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMAT 3786
Query: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
N G + +L V PS P+N+ V V+ CEA G P P++ WRK+ L
Sbjct: 3787 NAAGTDRRRI-DLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLN 3845
Query: 265 ----KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRD 320
++ Y + +L I + D +Y C N G + + LTVQ PP +P D
Sbjct: 3846 VDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTD 3905
Query: 321 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
+V C A+G P P+I W + G + L P+ + + +G + I Q
Sbjct: 3906 FLVTKHAPAVITCTASGVPFPSIHWTKNGIRLL------PRGDG-YRILSSGAIEILATQ 3958
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 440
+ G Y C N AGS L V + PPVI+ P V ++ +L C AT
Sbjct: 3959 LNHAGRYTCVARNAAGSAHRHVTLHVHE------PPVIQPQPSELHVILNNPILLPCEAT 4012
Query: 441 GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 500
G+P P I W+K+G+ V+T L +G LQI A D G Y C+A P+G A
Sbjct: 4013 GTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIK 4072
Query: 501 IEVQ 504
+ VQ
Sbjct: 4073 LNVQ 4076
Score = 212 bits (539), Expect = 3e-54
Identities = 158/519 (30%), Positives = 231/519 (44%), Gaps = 38/519 (7%)
Query: 48 LNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYV 107
+ C+A G P P I W K G + SH LL +G + +RIV + S D VY
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLS-----SHIRLLAAGQV--IRIVRAQVS--DVAVYT 3412
Query: 108 CVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKK 167
CVA N G H A D ++ V G M C G P P+++W +
Sbjct: 3413 CVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITD-GTPAPSMAWLR 3471
Query: 168 DGSPLD-DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSF- 225
DG PL D ++ G L + D+GKY C+ +N GE L VLE P
Sbjct: 3472 DGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFI-LKVLEPPHIN 3530
Query: 226 -VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY--EIRDDHTLKIRKVT 282
+ ++V V++ E C A G P P + W KD LP++ + L+I
Sbjct: 3531 GSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQ 3590
Query: 283 AGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV--KPRDQVVALGRTVTFQCEATGNPQ 340
D G YTC+A + G + + V PP+ +PRD V R VT +C++ P
Sbjct: 3591 VEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPP 3650
Query: 341 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSII 399
P I W R G + Q++ R + G L I N D Y C N+AG
Sbjct: 3651 PVITWLRNGERL--------QATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKT- 3701
Query: 400 TKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQ 459
T+ ++ +V PP I+ GP + + ++ + VL C+A G P P I WRKDG +++
Sbjct: 3702 TREFILTVNV-----PPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGN 3756
Query: 460 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 519
+R LENG L I+ A + DTGRY C+A+ +G T I++Q P P PT+
Sbjct: 3757 HARYSILENGFLHIQSAHVTDTGRYLCMATNAAG--TDRRRIDLQVHVPPSIAPGPTNMT 3814
Query: 520 LIPSAPSKPEVTDVSRNTVTLSWQPN---LNSGATPTSY 555
+I + + +++W+ N LN SY
Sbjct: 3815 VIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSY 3853
Score = 206 bits (525), Expect = 1e-52
Identities = 145/482 (30%), Positives = 212/482 (43%), Gaps = 31/482 (6%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP I H + +++ +P TL+C+A+G P P I W+K G + + +L SGS
Sbjct: 4078 PPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVES-----IRQRVLSSGS 4132
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
L + G D G Y C+A N G + S + L V + R V
Sbjct: 4133 LQIAFVQPG-----DAGHYTCMAANVAGSS-STSTKLTVHV-PPRIRSTEGHYTVNENSQ 4185
Query: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNM 206
A++ C G P P I+WKKD L + + T G+L++ D+G Y CV N
Sbjct: 4186 AILPCVAD-GIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNA 4244
Query: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
GE ++ LTV P+F + P ++++ + C+A G P+P + W ++ +P
Sbjct: 4245 AGE-DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAH 4303
Query: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK-PRDQVVAL 325
+ L I +V+ D G+Y C AEN VG +A + V+EPP F P + + L
Sbjct: 4304 FDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPL 4363
Query: 326 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 385
G CE G+P P I W R+G + S R G L I D G
Sbjct: 4364 GGNAILNCEVKGDPTPTIQWNRKGVDI--------EISHRIRQLGNGSLAIYGTVNEDAG 4415
Query: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 445
Y C N AG + L + + PP+I PV + G +L+C ATG P P
Sbjct: 4416 DYTCVATNEAGVVERSMSLTL------QSPPIITLEPVETVINAGGKIILNCQATGEPQP 4469
Query: 446 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 505
TI W + G +S D R+ L N L I A+ DT + C+A G + VQ
Sbjct: 4470 TITWSRQGHSIS-WDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQV 4528
Query: 506 FG 507
G
Sbjct: 4529 HG 4530
Score = 196 bits (498), Expect = 2e-49
Identities = 151/485 (31%), Positives = 230/485 (47%), Gaps = 47/485 (9%)
Query: 37 DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHG 96
D+I++ P +L C+ P PT+ WYK G + T D ++LP G + +
Sbjct: 2788 DVIINN--PISLYCETNAAPPPTLTWYKDGHPL-TSSDKV----LILPGGRVLQIP---- 2836
Query: 97 RKSRPDEGVYVCVARNYLGE-AVSHNASLEVA-ILRDDFRQNPSDVMVAVGEPAVMECQP 154
R D G Y CVA N GE ++ ++ + V I++ P +V V V + A++EC
Sbjct: 2837 RAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLS 2896
Query: 155 PRGHPEPTISWKKDGSPLDDKDERITIRGGKLM-ITYTRKSDAGKYVCVGTNMVGERESE 213
G P P SW+KDG PL + D + G+++ I T+ +D G+YVCV N G + +
Sbjct: 2897 S-GSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAK-K 2954
Query: 214 VAELTVLERPSFV-KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG--ELPKSRYEI 270
L V PS + + NL V V++ CE G P P + W K++ +L + +
Sbjct: 2955 YFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIV 3014
Query: 271 RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV------VA 324
TL+I + D G YTC+A N G+++ +LTV PP +K D V
Sbjct: 3015 PGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS--IKDHDSESLSVVNVR 3072
Query: 325 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSD 383
G +V+ +CE+ P P I W + G S+ + G L I + SD
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMIT--------ESTHVEILADGQMLHIKKAEVSD 3124
Query: 384 VGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCVATG 441
G Y+C+ +NVAG +L V PP I +GP + + + L+C ATG
Sbjct: 3125 TGQYVCRAINVAGRDDKNFHLNVY------VPPSI-EGPEREVIVETISNPVTLTCDATG 3177
Query: 442 SPVPTILWRKDGVLVSTQDS-RIKQLENGV-LQIRYAKLGDTGRYTCIASTPSGEATWSA 499
P PTI W K+ + DS ++ L G LQI ++ D+G YTCIAS G+A
Sbjct: 3178 IPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYY 3237
Query: 500 YIEVQ 504
++ +Q
Sbjct: 3238 FLSIQ 3242
Score = 191 bits (485), Expect = 5e-48
Identities = 145/494 (29%), Positives = 227/494 (45%), Gaps = 46/494 (9%)
Query: 33 EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLR 92
E +++ V + L C+ EG P+P I WYK +V S + +G + L
Sbjct: 1365 EQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTES-----STIQTVNNGKILKLF 1419
Query: 93 IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN-PSDVMVAVGEPAVME 151
R + D G Y C A N G + + +++V + N P++V V + +E
Sbjct: 1420 ----RATPEDAGRYSCKAINIAGTSQKY-FNIDVLVPPTIIGTNFPNEVSVVLNRDVALE 1474
Query: 152 CQPPRGHPEPTISWKKDGSPL--DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGE 209
CQ +G P P I W KDG PL D + + RG L + R++D G+Y C +N G+
Sbjct: 1475 CQV-KGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGK 1533
Query: 210 RESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR 267
+ ++ +LT+ PS ++++V ++ + +CE RG P+P + W KD + S
Sbjct: 1534 QAKDI-KLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSS 1592
Query: 268 YEIRDD--HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHF---VVKPRDQV 322
+ D L I + D +YTC N+ G AE S + V PP + P ++
Sbjct: 1593 QALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQ 1652
Query: 323 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQR 381
V + ++T +C+A GNP P + W ++G P +++ + G L I + Q
Sbjct: 1653 VVIAHSLTLECKAAGNPSPILTWLKDGV--------PVKANDNIRIEAGGKKLEIMSAQE 1704
Query: 382 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ--TVAVDGTFVLSCVA 439
D G YIC +VAG K ++V PP I G V V+ L C
Sbjct: 1705 IDRGQYICVATSVAGEKEIKYEVDVL------VPPAIEGGDETSYFIVMVNNLLELDCHV 1758
Query: 440 TGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 499
TGSP PTI+W KDG L+ +D L L I A++ +TG Y C+A+ +G+
Sbjct: 1759 TGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGD----- 1813
Query: 500 YIEVQEFGVPVQPP 513
+EF V V P
Sbjct: 1814 --HKKEFEVTVHVP 1825
Score = 191 bits (484), Expect = 6e-48
Identities = 148/500 (29%), Positives = 223/500 (44%), Gaps = 52/500 (10%)
Query: 34 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
HP+++IV++G+ +L C+ +G P PT+ W K G + K +L G + L+
Sbjct: 2298 HPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE-----ILDEGHILQLKN 2352
Query: 94 VHGRKSRPDEGVYVCVARNYLGEA-VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152
+H D G YVCVA N G ++ S+ ++P ++ V + C
Sbjct: 2353 IHVS----DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTC 2408
Query: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM-ITYTRKSDAGKYVCVGTNMVGERE 211
+ G P P+I+W KDG P+ + + GG+++ + T DAG+Y CV N GE E
Sbjct: 2409 EAS-GIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGE-E 2466
Query: 212 SEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK--SR 267
++ L+VL P V + ++ V S CE G+PVP + W KD L + +
Sbjct: 2467 RKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAH 2526
Query: 268 YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV-----KPRDQV 322
+ I L+I V G YTC+A + G S +L V P P D
Sbjct: 2527 HIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVT 2586
Query: 323 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQR 381
V L + CEA P I W ++G+ P +S+ + G L I N Q
Sbjct: 2587 VILNSPTSLVCEAYSYPPATITWFKDGT--------PLESNRNIRILPGGRTLQILNAQE 2638
Query: 382 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG--------PVNQTVAVDGTF 433
+ G Y C N AG +I + EV I PP+I +G P + V+ T
Sbjct: 2639 DNAGRYSCVATNEAGEMIK--HYEVKVYI----PPIINKGDLWGPGLSPKEVKIKVNNTL 2692
Query: 434 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 493
L C A P ++ W KDG + + D LQI+ A++ DTGRYTC+AS +G
Sbjct: 2693 TLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG 2752
Query: 494 EATWSAYIEVQEFGVPVQPP 513
E + +F V +Q P
Sbjct: 2753 E-------DELDFDVNIQVP 2765
Score = 189 bits (480), Expect = 2e-47
Identities = 170/605 (28%), Positives = 269/605 (44%), Gaps = 91/605 (15%)
Query: 28 PPRIVEHPS--DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP IV + D+ V + + TL C+ G P P I W+K G+ ++ D+ +H ++ S
Sbjct: 2477 PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDE----AHHII--S 2530
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGE---AVSHNASLEVAILRDDFRQNPSDVMV 142
G F L+I + + P G Y C+A + G + S N + I NP DV V
Sbjct: 2531 GGRF-LQITNVQV--PHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTV 2587
Query: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYVC 201
+ P + C+ +P TI+W KDG+PL+ +++ RI G L I ++ +AG+Y C
Sbjct: 2588 ILNSPTSLVCEA-YSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSC 2646
Query: 202 VGTNMVGERESEVAELTVLERPSFVK--------RPSNLAVTVDDSAEFKCEARGDPVPT 253
V TN GE E+ V P K P + + V+++ +CEA P +
Sbjct: 2647 VATNEAGEMIKHY-EVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSAS 2705
Query: 254 VRWRKDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 310
+ W KD G+ KS + + HTL+I++ D G YTCVA N+ G+ E + +Q
Sbjct: 2706 LSWYKD-GQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQV 2764
Query: 311 PPHFVV------------KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQ 358
PP F + V + ++ CE P P + W ++G
Sbjct: 2765 PPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDG--------H 2816
Query: 359 PPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 417
P SS + + G L I + D G Y C +N AG + + V PP+
Sbjct: 2817 PLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL------VPPI 2870
Query: 418 IRQG----PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQ 472
I+ P TV V+ + ++ C+++GSP P W+KDG + +D K L NG +LQ
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPL-LEDDHHKFLSNGRILQ 2929
Query: 473 IRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTD 532
I ++ D GRY C+A +G A + F + V P P++I P +T
Sbjct: 2930 ILNTQITDIGRYVCVAENTAGSAK-------KYFNLNVHVP----PSVI--GPKSENLTV 2976
Query: 533 VSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYL 592
V N ++L+ + SG P SW + +K T+ + + P L
Sbjct: 2977 VVNNFISLTCEV---SGFPPPDL-----------SWLKNEQPIKLNTNTL--IVPGGRTL 3020
Query: 593 FLVRA 597
++RA
Sbjct: 3021 QIIRA 3025
Score = 181 bits (459), Expect = 5e-45
Identities = 155/536 (28%), Positives = 236/536 (44%), Gaps = 50/536 (9%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP I+ ++ V + L C+++ P PT+ W K G + L S +
Sbjct: 2103 PPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPG-------LSISEN 2155
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAIL---RDDFRQNPSDVMVA 143
L+I + D G Y C A N G+ ++N ++ V D+ Q + V
Sbjct: 2156 RSVLKIEDAQVQ--DTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQ----LTVI 2209
Query: 144 VGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGG--KLMITYTRKSDAGKYV 200
G + C+ G P P + WKK GSP L D R+ I G +L I+ KSDA Y
Sbjct: 2210 EGNLISLLCESS-GIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYS 2268
Query: 201 CVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
CV +N+ G + E L V RP+ P+ + VT S +CE +G P PTV W
Sbjct: 2269 CVASNVAGTAKKEY-NLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWM 2327
Query: 258 KDDGELPKSR-YEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
KD L K++ EI D+ H L+++ + D G Y CVA N+ G + L+V PP +
Sbjct: 2328 KDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSII 2387
Query: 316 ---VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372
P + V +V+ CEA+G P P+I W ++G + S+S +S
Sbjct: 2388 GNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDG-------WPVSLSNSVRILSGGR 2440
Query: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT-VAVDG 431
L + D G Y C N AG ++ + PP ++ + + V
Sbjct: 2441 MLRLMQTTMEDAGQYTCVVRNAAGE-----ERKIFGLSVLVPPHIVGENTLEDVKVKEKQ 2495
Query: 432 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 491
+ L+C TG+PVP I W KDG + ++ LQI ++ TGRYTC+AS+P
Sbjct: 2496 SVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSP 2555
Query: 492 SGEATWSAYIEVQEFGVPV-----QPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 542
+G + S + V F P P D +I ++P+ S T++W
Sbjct: 2556 AGHKSRSFSLNV--FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITW 2609
Score = 179 bits (455), Expect = 1e-44
Identities = 157/548 (28%), Positives = 236/548 (43%), Gaps = 47/548 (8%)
Query: 28 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP I+ P+++ V L C+ +G P P I W+K G+ + DP LL
Sbjct: 1451 PPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG--DPNVE--LLDR 1506
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN-PSDVMVAV 144
G + L+ R D+G Y C N G+ + L + I N +D+ V +
Sbjct: 1507 GQVLHLK----NARRNDKGRYQCTVSNAAGKQAK-DIKLTIYIPPSIKGGNVTTDISVLI 1561
Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDAGKYVCVG 203
+EC+ RG P P I+W KDG P+ + + I +G L I + SD+ Y C
Sbjct: 1562 NSLIKLECET-RGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHV 1620
Query: 204 TNMVGERESEVAELTVLERPSF---VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260
N+ G E + V P + P N V + S +C+A G+P P + W KD
Sbjct: 1621 ANVAGTAEKSF-HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKD- 1678
Query: 261 GELPKSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 317
G K+ IR + L+I D G Y CVA ++ G+ E + V PP ++
Sbjct: 1679 GVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPP--AIE 1736
Query: 318 PRDQ----VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG- 372
D+ +V + + C TG+P P I W ++G Q F + G
Sbjct: 1737 GGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDG--------QLIDERDGFKILLNGR 1788
Query: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 432
L I Q S+ G Y C N AG K EVT + PP I+ +++ V V
Sbjct: 1789 KLVIAQAQVSNTGLYRCMAANTAGD--HKKEFEVTVHV----PPTIKSSGLSERVVVKYK 1842
Query: 433 FV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIAST 490
V L C+A G P P+I W KD V+T +K +G VLQI L D GRYTC+A+
Sbjct: 1843 PVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATN 1902
Query: 491 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN--LNS 548
+GE + V E + + ++ S P + E ++W + L S
Sbjct: 1903 AAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS 1962
Query: 549 GATPTSYI 556
G+T +++
Sbjct: 1963 GSTSMTFL 1970
Score = 178 bits (452), Expect = 3e-44
Identities = 159/563 (28%), Positives = 236/563 (41%), Gaps = 59/563 (10%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP +++ P+++ V+ GE A L C + W + + R R+ P+
Sbjct: 519 PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQR----------NDRDVRLAEPARI 568
Query: 88 LFFLRIVHGRKSRP--DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA-- 143
+ KS D G Y C+ + E S AS+ + + Q P V V
Sbjct: 569 RTLANLSLELKSVKFNDAGEYHCMVSS---EGGSSAASVFLTV------QEPPKVTVMPK 619
Query: 144 ----VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKY 199
G V G+P+P I+W + + G L I DAG Y
Sbjct: 620 NQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIY 679
Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
C+ +N G + + + L +E P + S L V + D +C+ G P P V+W K
Sbjct: 680 GCLASNSAGT-DKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKG 738
Query: 260 DGELPKSRYEIRDD--HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 317
D EL S + I D LKI++ D G YTCVA N G+A TL V PP F+ +
Sbjct: 739 DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQE 798
Query: 318 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 377
P D + +G VT C G P+P I WRR + + + P S S S +TG L I
Sbjct: 799 PADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPI---FSRPFSVSSISQLRTGALFIL 855
Query: 378 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 437
N+ SD G YIC+ N G I ++ + VT ++A P+I P V L C
Sbjct: 856 NLWASDKGTYICEAENQFGKIQSETTVTVTGLVA----PLIGISPSVANVIEGQQLTLPC 911
Query: 438 -VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG--E 494
+ G+P+P W K+ ++ Q+ I +G L I +L D G YTC+AS +G
Sbjct: 912 TLLAGNPIPERRWIKNSAML-LQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNN 970
Query: 495 ATWSAYIEV-------QEF-----GVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 542
T S + V Q+ G+PV P N KP V + + +
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGN------PKPSVIWSKKGELISTS 1024
Query: 543 QPNLNSGATPTSYIIEAFSHASG 565
++GA + Y++ SG
Sbjct: 1025 SAKFSAGADGSLYVVSPGGEESG 1047
Score = 177 bits (449), Expect = 7e-44
Identities = 140/468 (29%), Positives = 201/468 (42%), Gaps = 34/468 (7%)
Query: 36 SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
+D+ V L C+ G P P I WYK G+ + + S + + G +L I
Sbjct: 1555 TDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSS-----SQALYIDKGQ--YLHIPR 1607
Query: 96 GRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQP 154
+ S D Y C N G A S + + V + + P + V + +EC+
Sbjct: 1608 AQVS--DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKA 1665
Query: 155 PRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 213
G+P P ++W KDG P+ D RI G KL I ++ D G+Y+CV T++ GE+E +
Sbjct: 1666 A-GNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK 1724
Query: 214 VAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 271
E+ VL P+ S V V++ E C G P PT+ W KD G+L R +
Sbjct: 1725 Y-EVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD-GQLIDERDGFK 1782
Query: 272 ---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP-RDQVVALGR 327
+ L I + + G Y C+A N G + +TV PP ++VV +
Sbjct: 1783 ILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK 1842
Query: 328 TVTFQCEATGNPQPAIFWRREGSQ-NLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 386
V QC A G P P+I W ++ N QSS R L I D G
Sbjct: 1843 PVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRV-------LQIAKTLLEDAGR 1895
Query: 387 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV-NQTVAVDGTFVLSCVATGSPVP 445
Y C N AG L V + PP + G + N+TV V L C A G+PVP
Sbjct: 1896 YTCVATNAAGETQQHIQLHVHE-----PPSLEDAGKMLNETVLVSNPVQLECKAAGNPVP 1950
Query: 446 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 493
I W KD L+S S ++ I A++ D G Y C+A +G
Sbjct: 1951 VITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAG 1998
Score = 177 bits (448), Expect = 1e-43
Identities = 136/473 (28%), Positives = 212/473 (44%), Gaps = 41/473 (8%)
Query: 36 SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
S+ +V K +P L C A G P P+I W K + V T + + + + SG + +
Sbjct: 1834 SERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK----IQSSGRVLQI---- 1885
Query: 96 GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVM---VAVGEPAVMEC 152
+ D G Y CVA N GE H +++ + ++ ++ V V P +EC
Sbjct: 1886 AKTLLEDAGRYTCVATNAAGETQQH---IQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC 1942
Query: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM-ITYTRKSDAGKYVCVGTNMVGERE 211
+ G+P P I+W KD L + G+++ I + SDAG Y CV N G E
Sbjct: 1943 KAA-GNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATE 2001
Query: 212 SEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE-- 269
+ L V PS + +AV V++ +CEARG P P++ W KD P S +
Sbjct: 2002 LFYS-LQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGS--PVSSFSNG 2058
Query: 270 ---IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALG 326
+ L + D G YTCVA N G+ + L V PP+ + + ++ V +
Sbjct: 2059 LQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLIS 2118
Query: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVG 385
+ V C++ P P + W ++G P S+S+ L I + Q D G
Sbjct: 2119 QAVELLCQSDAIPPPTLTWLKDG--------HPLLKKPGLSISENRSVLKIEDAQVQDTG 2170
Query: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV-LSCVATGSPV 444
Y C+ NVAG T+ V + PP + + Q ++G + L C ++G P
Sbjct: 2171 RYTCEATNVAGK--TEKNYNVNIWV---PPNIGGSDELTQLTVIEGNLISLLCESSGIPP 2225
Query: 445 PTILWRKDGVLVSTQD-SRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGEA 495
P ++W+K G V T R++ L G LQI A+ D Y+C+AS +G A
Sbjct: 2226 PNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTA 2278
Score = 175 bits (443), Expect = 4e-43
Identities = 138/491 (28%), Positives = 211/491 (42%), Gaps = 40/491 (8%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP+I P L V G+ + C A+G P P I W KGG + D + H + P G+
Sbjct: 1170 PPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGE----HHVSNPDGT 1225
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLG----EAVSHNASLEVAILRDDFRQNPSDVMVA 143
L + + D G+Y CVA N G E H E + D +
Sbjct: 1226 LSI-----DQATPSDAGIYTCVATNIAGTDETEITLH--VQEPPTVEDLEPPYNTTFQER 1278
Query: 144 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI--RGGKLMITYTRKSDAGKYVC 201
V + P +G P+PTI W +G L ++ I+I G L+I D G+Y+C
Sbjct: 1279 VANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYIC 1338
Query: 202 VGTNMVGERESEVAELTVLERPSF--VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
V N G E + L V P ++ +N++V ++ CE G P P + W KD
Sbjct: 1339 VAVNEAGTTERKY-NLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKD 1397
Query: 260 DGELPKSR--YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 317
+ ++ +S + + LK+ + T D G Y+C A N+ G ++ + V PP +
Sbjct: 1398 NVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGT 1457
Query: 318 --PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-L 374
P + V L R V +C+ G P P I W ++G LF P + G L
Sbjct: 1458 NFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP--LFLGDP-----NVELLDRGQVL 1510
Query: 375 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ--TVAVDGT 432
+ N +R+D G Y C N AG L + PP I+ G V +V ++
Sbjct: 1511 HLKNARRNDKGRYQCTVSNAAGKQAKDIKLTI------YIPPSIKGGNVTTDISVLINSL 1564
Query: 433 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 492
L C G P+P I W KDG + + + + L I A++ D+ YTC + +
Sbjct: 1565 IKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVA 1624
Query: 493 GEATWSAYIEV 503
G A S +++V
Sbjct: 1625 GTAEKSFHVDV 1635
Score = 171 bits (432), Expect = 7e-42
Identities = 150/533 (28%), Positives = 237/533 (44%), Gaps = 67/533 (12%)
Query: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
P ++ + TL C+A P+ ++ WYK G+ +++D H + +G L+I
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSD-----DHVNIAANGHT--LQIK 2733
Query: 95 HGRKSRPDEGVYVCVARNYLGE-----------AVSHNASLEVAILRDDFRQNPSDVMVA 143
+ S D G Y CVA N GE S E+ + D R + ++
Sbjct: 2734 EAQIS--DTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVI- 2790
Query: 144 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCV 202
+ P + C+ P PT++W KDG PL D+ + + GG+ L I + DAG+Y CV
Sbjct: 2791 INNPISLYCET-NAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCV 2849
Query: 203 GTNMVGERESEVAELTVLERPSFVKR-----PSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
N GE +S ++ VL P +K P + V V+ SA +C + G P P W+
Sbjct: 2850 AVNEAGE-DSLQYDVRVLV-PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQ 2907
Query: 258 KDDGELPKSRYE--IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
KD L + + + + L+I D+G Y CVAEN G A+ L V PP +
Sbjct: 2908 KDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVI 2967
Query: 316 -VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-D 373
K + V + ++ CE +G P P + W L + QP + ++ + G
Sbjct: 2968 GPKSENLTVVVNNFISLTCEVSGFPPPDLSW--------LKNEQPIKLNTNTLIVPGGRT 3019
Query: 374 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV---D 430
L I + SD G Y C +N AG K L V PP I+ V +
Sbjct: 3020 LQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVY------VPPSIKDHDSESLSVVNVRE 3073
Query: 431 GTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIA 488
GT V L C + P P I W K+G ++ T+ + ++ L +G +L I+ A++ DTG+Y C A
Sbjct: 3074 GTSVSLECESNAVPPPVITWYKNGRMI-TESTHVEILADGQMLHIKKAEVSDTGQYVCRA 3132
Query: 489 STPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 541
+G + ++ V VP P++ P + + + N VTL+
Sbjct: 3133 INVAGRDDKNFHLNVY---VP--------PSI--EGPEREVIVETISNPVTLT 3172
Score = 170 bits (431), Expect = 9e-42
Identities = 143/500 (28%), Positives = 219/500 (43%), Gaps = 59/500 (11%)
Query: 28 PPRIVEH---PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
PP I+ + P ++ V + +L C+A G P P+I W+K G V S+ + +
Sbjct: 2383 PPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSL------SNSVRIL 2436
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP-SDVMVA 143
SG LR++ + + D G Y CV RN GE L V + +N DV V
Sbjct: 2437 SGGRM-LRLM--QTTMEDAGQYTCVVRNAAGEE-RKIFGLSVLVPPHIVGENTLEDVKVK 2492
Query: 144 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCV 202
+ + C+ G+P P I+W KDG PL + + I GG+ L IT + G+Y C+
Sbjct: 2493 EKQSVTLTCEVT-GNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCL 2551
Query: 203 GTNMVGERESEVAELTVLERPSFVK-----RPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
++ G + S L V P+ P ++ V ++ CEA P T+ W
Sbjct: 2552 ASSPAGHK-SRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWF 2610
Query: 258 KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHF 314
KD L +R IR TL+I + G Y+CVA N G+ + V PP
Sbjct: 2611 KDGTPLESNR-NIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPII 2669
Query: 315 V--------VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 366
+ P++ + + T+T +CEA P ++ W ++G QP +S
Sbjct: 2670 NKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDG--------QPLKSDDHV 2721
Query: 367 SVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN- 424
+++ G L I Q SD G Y C N+AG + L+ DV PP + +
Sbjct: 2722 NIAANGHTLQIKEAQISDTGRYTCVASNIAG----EDELDF-DVNIQVPPSFQKLWEIGN 2776
Query: 425 ----------QTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 474
+ V ++ L C +P PT+ W KDG +++ D + VLQI
Sbjct: 2777 MLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIP 2836
Query: 475 YAKLGDTGRYTCIASTPSGE 494
AK+ D GRYTC+A +GE
Sbjct: 2837 RAKVEDAGRYTCVAVNEAGE 2856
Score = 169 bits (428), Expect = 2e-41
Identities = 149/484 (30%), Positives = 216/484 (44%), Gaps = 44/484 (9%)
Query: 28 PPRIVEHPSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
PP ++ S+ L V +L C+ G P P + W K + ++ + ++ +++P G
Sbjct: 2963 PPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLN-----TNTLIVPGG 3017
Query: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVMVA 143
L+I+ + S D G Y C+A N GE+ SL V + ++D ++ S V V
Sbjct: 3018 RT--LQIIRAKVS--DGGEYTCIAINQAGES-KKKFSLTVYVPPSIKDHDSESLSVVNVR 3072
Query: 144 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCV 202
G +EC+ P P I+W K+G + + I G L I SD G+YVC
Sbjct: 3073 EGTSVSLECES-NAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCR 3131
Query: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAV-TVDDSAEFKCEARGDPVPTVRWRKDDG 261
N+ G R+ + L V PS + V T+ + C+A G P PT+ W K+
Sbjct: 3132 AINVAG-RDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK 3190
Query: 262 ELPKS-RYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 317
+ S E+R L+I + D G+YTC+A NM GKA+ L++Q PP
Sbjct: 3191 RIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGA 3250
Query: 318 --PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS--SSRFSVSQTGD 373
P D V LG V C A G P P I W ++G +P S + R VS G
Sbjct: 3251 EIPSDVSVLLGENVELVCNANGIPTPLIQWLKDG--------KPIASGETERIRVSANGS 3302
Query: 374 -LTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 430
L I SD G Y C N AG I + VT I + VD
Sbjct: 3303 TLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGN-----KDEAEKLMTLVD 3357
Query: 431 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIAS 489
+ + C ATG+P P I W K+G L S I+ L G V++I A++ D YTC+AS
Sbjct: 3358 TSINIECRATGTPPPQINWLKNG-LPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVAS 3416
Query: 490 TPSG 493
+G
Sbjct: 3417 NRAG 3420
Score = 163 bits (413), Expect = 1e-39
Identities = 140/498 (28%), Positives = 212/498 (42%), Gaps = 45/498 (9%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
P I + + V P L C+A G P P++ W K G V + + +L G +
Sbjct: 2012 PSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNG----LQVLSGGRI 2067
Query: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
L D G Y CVA N GE + L V + + +V V + +
Sbjct: 2068 LALT----SAQISDTGRYTCVAVNAAGEK-QRDIDLRVYV-PPNIMGEEQNVSVLISQAV 2121
Query: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
+ CQ P PT++W KDG PL K I+ L I + D G+Y C TN+
Sbjct: 2122 ELLCQSD-AIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180
Query: 208 GERESEV-AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE-LPK 265
G+ E + V + L V + CE+ G P P + W+K L
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTD 2240
Query: 266 SRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV---VKPR 319
S +R L+I D Y+CVA N+ G A+ L V P P
Sbjct: 2241 SMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPT 2300
Query: 320 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITN 378
+ +V G++++ +CE G P P + W ++G P + + G L + N
Sbjct: 2301 EIIVTRGKSISLECEVQGIPPPTVTWMKDG--------HPLIKAKGVEILDEGHILQLKN 2352
Query: 379 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI--RQGPVNQTVAVDGTFVLS 436
+ SD G Y+C +NVAG + K Y D+ PP +I + P N +V + L+
Sbjct: 2353 IHVSDTGRYVCVAVNVAG-MTDKKY----DLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407
Query: 437 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGEA 495
C A+G P+P+I W KDG VS +S ++ L G +L++ + D G+YTC+ +GE
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNS-VRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGE- 2465
Query: 496 TWSAYIEVQEFGVPVQPP 513
E + FG+ V P
Sbjct: 2466 ------ERKIFGLSVLVP 2477
Score = 160 bits (405), Expect = 9e-39
Identities = 138/525 (26%), Positives = 214/525 (40%), Gaps = 62/525 (11%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKA-EGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
P I PS V +G+ TL C G P P W K + + + + GS
Sbjct: 890 PLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNP-----YITVRSDGS 944
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAV-GE 146
L R+ D G Y CVA N G ++N + V + Q+ ++ + G
Sbjct: 945 LHIERV-----QLQDGGEYTCVASNVAG---TNNKTTSVVVHVLPTIQHGQQILSTIEGI 996
Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTN 205
P + C+ G+P+P++ W K G + + + G L + ++G+YVC TN
Sbjct: 997 PVTLPCKAS-GNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATN 1055
Query: 206 MVGERESEVAELTVLERPSFV--------KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
G + +V +LTV RP +P ++V + CE + P P + W
Sbjct: 1056 TAGYAKRKV-QLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWA 1114
Query: 258 KDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
K+ + R+ ++KI + D G Y CVA N+ G + L V PP
Sbjct: 1115 KETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQ 1174
Query: 316 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375
P+ V +G+ V C A G P P I W + GS L+ + G L+
Sbjct: 1175 RGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLV-------DGEHHVSNPDGTLS 1227
Query: 376 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD--VIADRPPP---VIRQGPVNQTVAVD 430
I SD G Y C N+AG+ T+ L V + + D PP ++ NQ +
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIE-- 1285
Query: 431 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIAS 489
C A G+P PTI W +G ++ ++ I LE+G +L I D G Y C+A
Sbjct: 1286 ----FPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAV 1341
Query: 490 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS 534
+G +++ + V P P K +VT+VS
Sbjct: 1342 NEAGTTE-------RKYNLKVHVP--------PVIKDKEQVTNVS 1371
Score = 160 bits (405), Expect = 9e-39
Identities = 140/481 (29%), Positives = 201/481 (41%), Gaps = 34/481 (7%)
Query: 28 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP + E PSD+ V GE L C A G PTP I+W K G+ + + + + + S
Sbjct: 3244 PPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETE-----RIRVS 3298
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVS-HNASLEVAILRDDFRQNPSDVMVAV 144
+ L I S D G Y CVA N GE N ++ V + +M V
Sbjct: 3299 ANGSTLNIYGALTS--DTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLV 3356
Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYVCVG 203
+EC+ G P P I+W K+G PL R+ G + I + SD Y CV
Sbjct: 3357 DTSINIECR-ATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVA 3415
Query: 204 TNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWRKDDG 261
+N G +++ L V P+ +TV S C G P P++ W +D
Sbjct: 3416 SNRAGV-DNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQ 3474
Query: 262 ELPKSRYEIRDDH--TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
L + H L++ K D G YTC+A N G+ L V EPPH
Sbjct: 3475 PLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEE 3534
Query: 320 DQVVA--LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 377
+ ++ + + C A+G P P + W ++G PQ+ ++ L I+
Sbjct: 3535 HEEISVIVNNPLELTCIASGIPAPKMTWMKDGR-------PLPQTDQVQTLGGGEVLRIS 3587
Query: 378 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI-RQGPVNQTVAVDGTFVLS 436
Q D G Y C + AG K YL V PP + P + TV + L
Sbjct: 3588 TAQVEDTGRYTCLASSPAGD-DDKEYLVRVHV----PPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 437 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGEA 495
C + P P I W ++G + R++ L G LQI A LGDT YTC+AS +G+
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQA-TPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKT 3701
Query: 496 T 496
T
Sbjct: 3702 T 3702
Score = 82.8 bits (203), Expect = 2e-15
Identities = 59/218 (27%), Positives = 84/218 (38%), Gaps = 13/218 (5%)
Query: 276 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA 335
L I KVT D G Y C+A + G A V EPP + P + V G C
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 336 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVA 395
+ W+R L +R L + +V+ +D G Y C +
Sbjct: 544 ISAVDYNLTWQRNDRDVRL------AEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEG 597
Query: 396 GSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVL 455
GS +L V + PP + P NQ+ + C ATG P P I W + +
Sbjct: 598 GSSAASVFLTVQE------PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMF 651
Query: 456 VSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 493
+ R + +G L I+ A D G Y C+AS +G
Sbjct: 652 I-VGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAG 688
Score = 68.2 bits (165), Expect = 6e-11
Identities = 47/149 (31%), Positives = 75/149 (50%), Gaps = 13/149 (8%)
Query: 369 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 428
S + +L I V SD G+Y C ++ AG+ + + +V++ PPPVI Q P N TV
Sbjct: 479 SASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE-----PPPVI-QVPNNVTVT 532
Query: 429 VDGTFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 487
VL+C+ + + W R D + + +RI+ L N L+++ K D G Y C+
Sbjct: 533 PGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCM 592
Query: 488 ASTPSGEATWSAYIEVQEFGVPVQPPRPT 516
S+ G + S ++ VQE PP+ T
Sbjct: 593 VSSEGGSSAASVFLTVQE------PPKVT 615
Score = 34.7 bits (78), Expect = 0.77
Identities = 28/103 (27%), Positives = 44/103 (42%), Gaps = 9/103 (8%)
Query: 446 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 505
T+ + ++GV + D +K+ + L I L D G Y CIA + +G + +V E
Sbjct: 460 TLSFVRNGVTLGV-DQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE 518
Query: 506 FGVPVQPPRPTDPNLIPSAPSKPEVTD---VSRNTVTLSWQPN 545
PP PN + P + V +S L+WQ N
Sbjct: 519 -----PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRN 556
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 219 bits (559), Expect = 1e-56
Identities = 228/871 (26%), Positives = 345/871 (39%), Gaps = 85/871 (9%)
Query: 10 LFGLICLCSGSRLRQEDFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGG 66
LF + +C + D+ P V+ P D+I S + LNC+ G P P+ W + G
Sbjct: 9 LFLSVTMCLSESV---DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNG 65
Query: 67 ERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV 126
++ + D +R L G+ I+ D G Y C+A N +G +S A+L+
Sbjct: 66 TEIDLESD----YRYSLIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQF 117
Query: 127 AILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRG 183
A L + + S V V G+ V+ C PP PE SW + P +D I+
Sbjct: 118 AYLGNFSGRTRSAVSVREGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQET 177
Query: 184 GKLMITYTRKSDAGKYVCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLA 233
G L I+ + SD G Y+C+ N V S LT+ E V P +
Sbjct: 178 GNLYISKVQTSDVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVT 237
Query: 234 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA 293
+ + +C A G+PVPT+ W K +G +P + L+I V D G Y C A
Sbjct: 238 AAKGTTVKMECFALGNPVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRA 297
Query: 294 ENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNL 353
EN GK L V PH+V K D + G + ++C+ATG P+P W + G
Sbjct: 298 ENSRGKNSFRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG---- 353
Query: 354 LFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADR 413
P SR + G L I NV +SD G Y C N G+I A L+ ++A
Sbjct: 354 ----VPLSPQSRVEM-VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASA 405
Query: 414 PPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 473
P + Q V D V+ C GSP PTI W+K G ++ RI L +G L+I
Sbjct: 406 PTFALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRI 464
Query: 474 RYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDV 533
A D G+Y C G A A + V+E P I P + E+T
Sbjct: 465 LNASKSDEGKYVCRGENVFGSAEIIASLSVKE------------PTRIELTPKRTELT-- 510
Query: 534 SRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLF 593
++ L+ + ++ T Y E+++ + S+ + N
Sbjct: 511 VGESIVLNCKAIHDASLDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----I 566
Query: 594 LVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIE 653
L+ A YG + Q + V+ G + + S++++
Sbjct: 567 LLMHAGRYG----------CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLS 616
Query: 654 VHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKAR 713
D S I Y + R + ++ V E+ T S + DL V YE +
Sbjct: 617 WSPAADNHSP-ISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV- 674
Query: 714 PFFNEFQGAD--SEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMV 771
N D + + +T E P P VS G ++++W+P E+ QNG
Sbjct: 675 VATNPIGTGDPSTPSRMIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEG 732
Query: 772 QEYKVWCLGNETRYHINKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKS 825
Y V N TR K V S S I P L P + V+V G G S
Sbjct: 733 FGYIVAFRPNGTRGWKEKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFS 789
Query: 826 EPQFIQLDAHGNP-VSPEDQVSLAQQISDVV 855
+ I A G P +P D + + +S+++
Sbjct: 790 QIVVI-CSAEGEPSAAPTDVKATSVSVSEIL 819
Score = 175 bits (443), Expect = 4e-43
Identities = 205/765 (26%), Positives = 303/765 (39%), Gaps = 106/765 (13%)
Query: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152
D G Y+C+ +N + A + + + D P V A G MEC
Sbjct: 189 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 248
Query: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
G+P PTI+W K + K R+ L I + DAG Y C N G + S
Sbjct: 249 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 305
Query: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271
+L V P +V++ ++ + ++C+A G P PT RW K+ L P+SR E+
Sbjct: 306 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 365
Query: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV-QEPPHFVVKPRDQ--VVALGRT 328
+ L I V D G Y C+AEN G ASA L + P F + + +V +
Sbjct: 366 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQE 424
Query: 329 VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI 388
V +C+ G+P+P I W++ + + + R ++ G L I N +SD G Y+
Sbjct: 425 VVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGKYV 476
Query: 389 CQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPVPT 446
C+ NV GS A L V + P I P + V + VL+C A S T
Sbjct: 477 CRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLDVT 530
Query: 447 ILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 500
W G + ++ S Q + L IR L GRY C T + + A
Sbjct: 531 FYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE 590
Query: 501 IEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 560
+ V+ PP P P V +++ +T TLSW P ++ + +SY ++A
Sbjct: 591 LLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR 635
Query: 561 SHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQISD 611
S S WQT VKT I G L P Y F V A N G DPS S
Sbjct: 636 SPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSR 690
Query: 612 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ-- 666
++T + +P + PT +S S H V + S+ Q
Sbjct: 691 MIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQNG 730
Query: 667 ---GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEFQG 721
GY + +RP+G W V + + + D + +E+K + N+ G
Sbjct: 731 EGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG 786
Query: 722 ADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-CLG 780
S+I + E PSA P V + + ILV+W+ E E W +
Sbjct: 787 PFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDME 844
Query: 781 NETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 825
E KT +F V++ L Y V A GAG G S
Sbjct: 845 QEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 888
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 219 bits (558), Expect = 2e-56
Identities = 225/855 (26%), Positives = 339/855 (39%), Gaps = 82/855 (9%)
Query: 26 DFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
D+ P V+ P D+I S + LNC+ G P P+ W + G ++ + D +R
Sbjct: 96 DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESD----YRYS 151
Query: 83 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
L G+ I+ D G Y C+A N +G +S A+L+ A L + + S V V
Sbjct: 152 LIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSV 207
Query: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTRKSDAGKY 199
G+ V+ C PP PE SW + P +D I+ G L I+ + SD G Y
Sbjct: 208 REGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSY 267
Query: 200 VCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLAVTVDDSAEFKCEARGD 249
+C+ N V S LT+ E V P + + + +C A G+
Sbjct: 268 ICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN 327
Query: 250 PVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
PVPT+ W K +G +P + L+I V D G Y C AEN GK L V
Sbjct: 328 PVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387
Query: 310 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 369
PH+V K D + G + ++C+ATG P+P W + G P SR +
Sbjct: 388 TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--------VPLSPQSRVEM- 438
Query: 370 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 429
G L I NV +SD G Y C N G+I A L+ ++A P + Q V
Sbjct: 439 VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASAPTFALNQLKKTIIVTK 495
Query: 430 DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 489
D V+ C GSP PTI W+K G ++ RI L +G L+I A D G+Y C
Sbjct: 496 DQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGE 554
Query: 490 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 549
G A A + V+E P I P + E+T ++ L+ + ++
Sbjct: 555 NVFGSAEIIASLSVKE------------PTRIELTPKRTELT--VGESIVLNCKAIHDAS 600
Query: 550 ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 609
T Y E+++ + S+ + N L+ A YG
Sbjct: 601 LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----ILLMHAGRYG------- 649
Query: 610 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYK 669
+ Q + V+ G + + S++++ D S I Y
Sbjct: 650 ---CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSP-ISSYN 705
Query: 670 ILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGAD--SEIK 727
+ R + ++ V E+ T S + DL V YE + N D + +
Sbjct: 706 LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV-VATNPIGTGDPSTPSR 764
Query: 728 FAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHI 787
+T E P P VS G ++++W+P E+ QNG Y V N TR
Sbjct: 765 MIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWK 822
Query: 788 NKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNP-VS 840
K V S S I P L P + V+V G G S+ I A G P +
Sbjct: 823 EKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFSQIVVI-CSAEGEPSAA 878
Query: 841 PEDQVSLAQQISDVV 855
P D + + +S+++
Sbjct: 879 PTDVKATSVSVSEIL 893
Score = 175 bits (443), Expect = 4e-43
Identities = 205/765 (26%), Positives = 303/765 (39%), Gaps = 106/765 (13%)
Query: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 152
D G Y+C+ +N + A + + + D P V A G MEC
Sbjct: 263 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 322
Query: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
G+P PTI+W K + K R+ L I + DAG Y C N G + S
Sbjct: 323 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 379
Query: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 271
+L V P +V++ ++ + ++C+A G P PT RW K+ L P+SR E+
Sbjct: 380 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 439
Query: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV-QEPPHFVVKPRDQ--VVALGRT 328
+ L I V D G Y C+AEN G ASA L + P F + + +V +
Sbjct: 440 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQE 498
Query: 329 VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI 388
V +C+ G+P+P I W++ + + + R ++ G L I N +SD G Y+
Sbjct: 499 VVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGKYV 550
Query: 389 CQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPVPT 446
C+ NV GS A L V + P I P + V + VL+C A S T
Sbjct: 551 CRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLDVT 604
Query: 447 ILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 500
W G + ++ S Q + L IR L GRY C T + + A
Sbjct: 605 FYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE 664
Query: 501 IEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 560
+ V+ PP P P V +++ +T TLSW P ++ + +SY ++A
Sbjct: 665 LLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR 709
Query: 561 SHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQISD 611
S S WQT VKT I G L P Y F V A N G DPS S
Sbjct: 710 SPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSR 764
Query: 612 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ-- 666
++T + +P + PT +S S H V + S+ Q
Sbjct: 765 MIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQNG 804
Query: 667 ---GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEFQG 721
GY + +RP+G W V + + + D + +E+K + N+ G
Sbjct: 805 EGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG 860
Query: 722 ADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-CLG 780
S+I + E PSA P V + + ILV+W+ E E W +
Sbjct: 861 PFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDME 918
Query: 781 NETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 825
E KT +F V++ L Y V A GAG G S
Sbjct: 919 QEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 962
Score = 129 bits (323), Expect = 3e-29
Identities = 190/794 (23%), Positives = 312/794 (39%), Gaps = 113/794 (14%)
Query: 80 RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--- 136
R+ S S F R S P G + ++LG A ++ + + + D F+Q+
Sbjct: 36 RIKKSSSSSLFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESV 95
Query: 137 ---------PSDVMVAVG---EPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRG 183
P D++ + + C+ RG+P P+ W ++G+ +D + D R ++
Sbjct: 96 DYGPVFVQEPDDIIFPTDSDEKKVALNCE-VRGNPVPSYRWLRNGTEIDLESDYRYSLID 154
Query: 184 GKLMITY-TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242
G +I+ + D+G Y C+ TN VG S A L +F R + AV+V +
Sbjct: 155 GTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGR-TRSAVSVREGQGV 213
Query: 243 KCEARGDP-VPTVRWRKDDGELP------KSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN 295
P P + + E P R+ ++ L I KV D+GSY C+ +N
Sbjct: 214 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273
Query: 296 MVGKAEA---SATLTVQ--------EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF 344
V A LT++ EP V P A G TV +C A GNP P I
Sbjct: 274 TVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTIT 333
Query: 345 WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYL 404
W + + Y P S +R SQ L I NVQ D G Y C+ N G + L
Sbjct: 334 WMK------VNGYIP--SKARLRKSQ-AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQL 384
Query: 405 EVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSPVPTILWRKDGVLVSTQDSRI 463
+V P + + +N T G+ C ATG P PT W K+GV +S Q SR+
Sbjct: 385 QVYTY-----PHWVEK--LNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ-SRV 436
Query: 464 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS 523
++ NGVL I D G Y C+A G SA +++ + S
Sbjct: 437 -EMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI-----------------LAS 478
Query: 524 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE----- 578
AP+ + + T+ ++ + P S G + V EN +
Sbjct: 479 APT--FALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGD--RAVRENKRIAILPDG 534
Query: 579 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 638
+ I + ++ R N +G ++I + ++ PT + K+ + +G ++
Sbjct: 535 SLRILNASKSDEGKYVCRGENVFG---SAEIIASLSVKE--PTRIELTPKRTELTVGESI 589
Query: 639 LHLHNPTVLSSSSIEV--HWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 696
+ N + +S++V +WT ++G I + G + +N
Sbjct: 590 --VLNCKAIHDASLDVTFYWT-------LKGQPIDFEEEGGHFESIRAQASSADLMIRNI 640
Query: 697 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 756
+++ R G + ADS A+ L P PP G+ + + TA L
Sbjct: 641 LLMHAGRYGCRVQTT----------ADSVSDEAELLVRGPPGPP-GIVIVEEITESTATL 689
Query: 757 VSWQPPPED---TQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEV 813
SW P ++ + +Q + LG +T + + + G S + L P + Y V
Sbjct: 690 -SWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV 748
Query: 814 AASTGAGSGVKSEP 827
A+ G+G S P
Sbjct: 749 VATNPIGTGDPSTP 762
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 208 bits (530), Expect = 3e-53
Identities = 149/478 (31%), Positives = 215/478 (44%), Gaps = 31/478 (6%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
P + PS + E L C+A G P PTI W K G V T +LP G L
Sbjct: 2666 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 2720
Query: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
RI H S D G Y+C+A+N G A+ V + D+ G A
Sbjct: 2721 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 2773
Query: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMV 207
+ C+ RG PEP I+W KDG P+ + + TI+ G+L++ DAG Y C N V
Sbjct: 2774 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2832
Query: 208 GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR 267
G V LT+L P F P + ++ + D +C ARG P P + W +D + +
Sbjct: 2833 GRARRRV-HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2891
Query: 268 YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA-LG 326
E TL+ V+ D G+Y C AEN VG+ +A + + V+E P + +V +G
Sbjct: 2892 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVG 2951
Query: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 386
++ C G+P P I W ++G P + S Q G LTI +R D G
Sbjct: 2952 GSIQLDCVVRGDPVPDIHWIKDGL--------PLRGSHLRHQLQNGSLTIRRTERDDAGR 3003
Query: 387 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 446
Y C N G + K + ++ + PV + P + TV L C ATG P PT
Sbjct: 3004 YQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT 3057
Query: 447 ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
I W + G + R++ L +G L + + GD G Y C+A G AT A++ V+
Sbjct: 3058 IEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3114
Score = 194 bits (493), Expect = 6e-49
Identities = 154/500 (30%), Positives = 220/500 (44%), Gaps = 40/500 (8%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
P I P + VS + A L C+A+G P P + W K +RV D PR +LP GSL
Sbjct: 2391 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK--DRVPLDPRSPRFE--ILPEGSL 2446
Query: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-FRQNPSDVMVAVGEP 147
++ D G Y+C+A N G S ++ +L +PS++ + P
Sbjct: 2447 RIQPVL-----AQDAGHYLCLASNSAG---SDRQGRDLRVLEPPAIAPSPSNLTLTAHTP 2498
Query: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIR---GGKLMITYTRKSDAGKYVCVGT 204
A++ C+ G P+P + W KDG LD + ++ R L++T D+ ++ CV +
Sbjct: 2499 ALLPCEAS-GSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVS 2557
Query: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
N VGE + ++TV P+ ++ VT+ C + G P PTV W K +L
Sbjct: 2558 NEVGEAH-RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG 2616
Query: 265 K--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV 322
S Y + L+I + G YTC A N G A LTVQ P VVKP V
Sbjct: 2617 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP--VVKPLPSV 2674
Query: 323 V--ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
V V CEA+G P+P I W++EG + V G L I +
Sbjct: 2675 VRAVAEEEVLLPCEASGIPRPTITWQKEGLN--------VATGVSTQVLPGGQLRIAHAS 2726
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 440
D G Y+C N AGS + K L V + PPVI G + + L C A
Sbjct: 2727 PEDAGNYLCIAKNSAGSAMGKTRLVV------QVPPVIENGLPDLSTTEGSHAFLPCKAR 2780
Query: 441 GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 500
GSP P I W KDG VS + + +G L ++ + D G YTC A G A +
Sbjct: 2781 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2840
Query: 501 IEVQEFGVPVQPPRPTDPNL 520
+ + +PV P D +L
Sbjct: 2841 LTI--LVLPVFTTLPGDRSL 2858
Score = 192 bits (489), Expect = 2e-48
Identities = 158/510 (30%), Positives = 222/510 (43%), Gaps = 49/510 (9%)
Query: 28 PPRI---VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
PP I + L+ GE T+ C G P + W K G + P S R LL
Sbjct: 2028 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 2080
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVM 141
GS LRI + D G++ CVA + G A N +L+V + L QN DV+
Sbjct: 2081 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 2135
Query: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201
V G + C+ RG P P +SW KDG PL + +G L + D+G Y C
Sbjct: 2136 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 2191
Query: 202 VGTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
V + GE +LTV+E P +P+ L++T E C+A+G P P + W KD
Sbjct: 2192 VAVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 2250
Query: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
L + R L++R D G YTC+AE+ G E S + VQ PP+ +V PR
Sbjct: 2251 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPN-IVGPR 2304
Query: 320 DQVVALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 376
+G + +C P P I W R+G ++ RF L +
Sbjct: 2305 GPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF-------LQL 2357
Query: 377 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 436
+ +D G Y C N AGS +E+ V P IR GP V+V+ T +L
Sbjct: 2358 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALLP 2411
Query: 437 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 496
C A G P P + WRKD V + + R + L G L+I+ D G Y C+AS +G
Sbjct: 2412 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 2471
Query: 497 WSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 526
+ V E P P P++ L P+
Sbjct: 2472 QGRDLRVLE--PPAIAPSPSNLTLTAHTPA 2499
Score = 186 bits (472), Expect = 2e-46
Identities = 156/542 (28%), Positives = 231/542 (42%), Gaps = 56/542 (10%)
Query: 28 PPRIVE--HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP I + P++L ++ G P L C A+G P P I W+K G+ + +++ R+ R+L
Sbjct: 2211 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 2270
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
D G+Y C+A + G S V + P VG
Sbjct: 2271 ----------------DAGLYTCLAESPAGAI---EKSFRVRVQAPPNIVGPRGPRFVVG 2311
Query: 146 ---EPAVMECQPPRGHPEPTISWKKDGSPL-DDKDERITIRGGKLMITYTRKSDAGKYVC 201
V+EC P P I+W +DG L +D + RG L + +D+G Y C
Sbjct: 2312 LAPGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSC 2370
Query: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
N G S + + P+ P + V+V+ +A C+A G P P V WRKD
Sbjct: 2371 TARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRV 2429
Query: 262 EL-PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
L P+S R+EI + +L+I+ V A D G Y C+A N G L V EPP P
Sbjct: 2430 PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 2489
Query: 320 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 379
+ + CEA+G+P+P + W ++G Q L F Q + + + L +T
Sbjct: 2490 NLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLLTAP 2544
Query: 380 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 439
D + C N G + Y V PP I + TV + VL+C +
Sbjct: 2545 GPQDSAQFECVVSNEVGE-AHRLYQVTVHV-----PPTIADDQTDFTVTMMAPVVLTCHS 2598
Query: 440 TGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 499
TG P PT+ W K G + + S + +G L+I A GRYTC A +G A
Sbjct: 2599 TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHV 2658
Query: 500 YIEVQEFGVPVQPPRPT-------DPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 552
++ VQ PV P P+ + L+P E + + R T+T WQ + AT
Sbjct: 2659 FLTVQ--ASPVVKPLPSVVRAVAEEEVLLPC-----EASGIPRPTIT--WQKEGLNVATG 2709
Query: 553 TS 554
S
Sbjct: 2710 VS 2711
Score = 184 bits (466), Expect = 8e-46
Identities = 168/527 (31%), Positives = 234/527 (44%), Gaps = 71/527 (13%)
Query: 47 TLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVY 106
TL C++ P PTI WYK G+ V P S +L G L L+I + S D G Y
Sbjct: 1376 TLECESWAVPPPTIRWYKDGQPVT-----PSSRLQVLGEGRL--LQIQPTQVS--DSGRY 1426
Query: 107 VCVARNYLGE-----------------AVSHNASLEVAILRDDFRQNPSDVMVAV-GEPA 148
+CVA N GE +A+ E+ ++ R ++ V PA
Sbjct: 1427 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1486
Query: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMV 207
+ C P P ++W ++ PL DE ++GG+ L I R +AG+Y C +N V
Sbjct: 1487 YLYCDT-NAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEV 1545
Query: 208 GERESEVAELTVLERPSFVKRPSNLA--VTVDDSA--EFKCEARGDPVPTVRWRKDDGEL 263
GE EL VL P + L VTV+ S+ +C A G+PVPT+ W ++
Sbjct: 1546 GEDWLHY-ELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPF 1604
Query: 264 -PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 321
P R ++ +D L++ D SY CVAEN G AE TL VQ PP +Q
Sbjct: 1605 SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQ 1664
Query: 322 VVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
V A L +V+ C+ +P P + W ++ SQ L + F + T L + +
Sbjct: 1665 VTAILNSSVSLPCDVHAHPNPEVTWYKD-SQALSLGEEV------FLLPGTHTLQLGRAR 1717
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ----TVAVDGTFVLS 436
SD G Y C+ LN AG L V PP RQ P V V VLS
Sbjct: 1718 LSDSGMYTCEALNAAGRDQKLVQLSVL------VPPAFRQAPRGPQDAVLVRVGDKAVLS 1771
Query: 437 CVATGSPVPTILWRKDG-VLVSTQDSRIKQLENGV-LQIRYAKLGDTGRYTCIASTPSGE 494
C P PT+ W KDG LV Q R + L G L+I+ A++ D G Y+C S +GE
Sbjct: 1772 CETDALPEPTVTWYKDGQPLVLAQ--RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1829
Query: 495 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 541
A V+ F + VQ P PT N P V+ V+ + + L+
Sbjct: 1830 A-------VRTFTLTVQVP-PTFEN-----PKTETVSQVAGSPLVLT 1863
Score = 181 bits (460), Expect = 4e-45
Identities = 145/478 (30%), Positives = 202/478 (42%), Gaps = 34/478 (7%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP I P + V + TL C A G P P + W+KG + V S + S
Sbjct: 603 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 655
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
LRI + S D G Y CVA N G + L V + V V P
Sbjct: 656 GRVLRIEQAQLS--DAGSYRCVASNVAG-STELRYGLRVNVPPRITLPPSLPGPVLVNTP 712
Query: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDE---RITIRGGKLMITYTRKSDAGKYVCVGT 204
+ C G P PT+ W KDG+P+ ++ G L + R SD+G+Y CV
Sbjct: 713 VRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 771
Query: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL- 263
+ VGE +V L V PS + N++V ++S +C++ P P + W KD L
Sbjct: 772 SAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 830
Query: 264 PKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV 322
P+ + D L ++ + D G YTC A N G +E L V P F ++ +
Sbjct: 831 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL 890
Query: 323 -VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQ 380
V G CE G P P I WR++G P + + VS G L + Q
Sbjct: 891 TVREGHPTRLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQAQ 944
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI---RQGPVNQTVAVDGTFVLSC 437
+ G Y C+ NV G+ LEV PP I R+ P +V DG L C
Sbjct: 945 LAQEGTYTCECSNVVGNSSQDLQLEV------HVPPQIAGPREPPTQVSVVQDGVATLEC 998
Query: 438 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 495
ATG P PT+ W +DG V + Q + L + A+ TGRY+C+A +G A
Sbjct: 999 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1056
Score = 178 bits (451), Expect = 4e-44
Identities = 142/515 (27%), Positives = 215/515 (41%), Gaps = 41/515 (7%)
Query: 1 MIAEPAHFYLFGLICLCS---GSRLRQEDF----PPRIVEHPSDLIVSKGEPATLNCKAE 53
++A+ A YL CL S GS + D PP I PS+L ++ PA L C+A
Sbjct: 2451 VLAQDAGHYL----CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 2506
Query: 54 GRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNY 113
G P P + W+K G++++ + LLPS +L D + CV N
Sbjct: 2507 GSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNALLLTA-----PGPQDSAQFECVVSNE 2559
Query: 114 LGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD 173
+GEA H + + +D V + P V+ C G P PT+SW K G+ L
Sbjct: 2560 VGEA--HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHST-GIPAPTVSWSKAGAQLG 2616
Query: 174 DKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNL 232
+ + G L I AG+Y C N G V LTV P PS +
Sbjct: 2617 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF-LTVQASPVVKPLPSVV 2675
Query: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTC 291
++ CEA G P PT+ W+K+ + ++ L+I + D G+Y C
Sbjct: 2676 RAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC 2735
Query: 292 VAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 351
+A+N G A L VQ PP D G C+A G+P+P I W ++G
Sbjct: 2736 IAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDG-- 2793
Query: 352 NLLFSYQPPQSSS-RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 410
QP + +F++ +G+L + N++ D G Y C N G + +L + +
Sbjct: 2794 ------QPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL- 2846
Query: 411 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 470
PV P ++++ + L C A GSP P I W + V+ S +Q
Sbjct: 2847 -----PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS--EQDGGST 2899
Query: 471 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 505
LQ D+G Y C A G +++ V+E
Sbjct: 2900 LQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE 2934
Score = 177 bits (449), Expect = 7e-44
Identities = 158/512 (30%), Positives = 225/512 (43%), Gaps = 58/512 (11%)
Query: 35 PSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
P D ++V G+ A L+C+ + P PT+ WYK G+ + L G L I
Sbjct: 1756 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL-----AQRTQALRGGQR--LEI 1808
Query: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153
+ S D+G+Y C N GEAV +L V + V G P V+ C
Sbjct: 1809 QEAQVS--DKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 1865
Query: 154 PPRGHPEPTISWKKDGSPLDDKD-ERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
G P PT++W KD P++ + RGG+L ++ + + AG Y CV N E
Sbjct: 1866 -VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 1924
Query: 213 EVAELTVLERPSFVKRPSNLA----VTVDDSAEFKCEARGDPVPTVRWRKDDGEL----- 263
+ + VL P R S +A V CEA G P P V W KD L
Sbjct: 1925 DFV-VAVLVAPRI--RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 1981
Query: 264 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV 323
P R+ + D +L ++ + A D G+YTCVA N G+ T+ V PP + + D
Sbjct: 1982 PHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPP-TIKQGADGSG 2039
Query: 324 AL----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITN 378
L G VT C G+P + W ++G P S R + +G L I+
Sbjct: 2040 TLVSRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISK 2091
Query: 379 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV---NQTVAVDGTFV- 434
VQ +D G + C + AG L+V + PPV+ PV N V V G+ V
Sbjct: 2092 VQLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLE--PVEFQNDVVVVRGSLVE 2143
Query: 435 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSG 493
L C A G P+P + W KDG + +Q LE G LQ+ GD+G Y+C+A + +G
Sbjct: 2144 LPCEARGVPLPLVSWMKDGEPLLSQ-----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAG 2198
Query: 494 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 525
EA + V E +PT+ +L P AP
Sbjct: 2199 EARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 2230
Score = 177 bits (448), Expect = 1e-43
Identities = 146/489 (29%), Positives = 212/489 (43%), Gaps = 44/489 (8%)
Query: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Q PP I+ ++ V E L C++ P P + W+K G +E PR L
Sbjct: 784 QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 838
Query: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 143
+L + R D G Y C A N G + H +L V + + + V
Sbjct: 839 ADKALLQV----DRADVWDAGHYTCEALNQAGHSEKH-YNLNVWVAPVFPLRESHTLTVR 893
Query: 144 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD---ERITIRGGKLMITYTRKSDAGKYV 200
G P + C+ RG P P ISW+KDG PL + + ++ G L + + + G Y
Sbjct: 894 EGHPTRLSCE-CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 952
Query: 201 CVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
C +N+VG S+ +L V P + P+ ++V D A +C A G P PTV W
Sbjct: 953 CECSNVVG-NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE 1011
Query: 258 KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHF 314
+ DG+ + ++ +L + + A G Y+CVAEN+ G+AE L+V PP
Sbjct: 1012 R-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1070
Query: 315 V--VKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
+ + P + AL +T CEA G P PAI W F + P S +
Sbjct: 1071 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW---------FRGEEPVSPGEDTYLLA 1121
Query: 372 GD--LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 429
G L +T Q D G Y C N AG +EV PP I + + + V
Sbjct: 1122 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEVIKV 1175
Query: 430 -DG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 487
DG T L C TG P P + W KDG ++ D+ + +LQ+ A L G Y+CI
Sbjct: 1176 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1235
Query: 488 ASTPSGEAT 496
A+ GE T
Sbjct: 1236 AANAVGEKT 1244
Score = 173 bits (439), Expect = 1e-42
Identities = 127/385 (32%), Positives = 176/385 (45%), Gaps = 32/385 (8%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP I DL ++G A L CKA G P P I W K G+ V + PSG
Sbjct: 2755 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS----GAEGKFTIQPSGE 2810
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
L ++ + G+ D G Y C A N +G A L + +L F P D + +G+
Sbjct: 2811 LL-VKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 2863
Query: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
+ C RG P P I W + P+ + G L + D+G YVC N V
Sbjct: 2864 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQD-GGSTLQRAAVSREDSGTYVCWAENRV 2921
Query: 208 GERES----EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 263
G ++ V E VL+ +F S L V S + C RGDPVP + W KD L
Sbjct: 2922 GRTQAVSFVHVKEAPVLQGEAF----SYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 2977
Query: 264 PKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 321
S R+++++ +L IR+ D G Y C+AEN +G A+ L +Q P F V+P+D
Sbjct: 2978 RGSHLRHQLQNG-SLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM 3036
Query: 322 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 381
V G V +C+ATG P P I W + G QP ++S R G L + NV+
Sbjct: 3037 TVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLENVET 3088
Query: 382 SDVGYYICQTLNVAGSIITKAYLEV 406
D G Y C N+ GS +A+L V
Sbjct: 3089 GDAGTYDCVAHNLLGSATARAFLVV 3113
Score = 172 bits (436), Expect = 2e-42
Identities = 152/556 (27%), Positives = 231/556 (41%), Gaps = 71/556 (12%)
Query: 28 PPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
PP+I E P+ + V + ATL C A G+P PT+ W + G+ V + L
Sbjct: 973 PPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG-----LQLQN 1027
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD----V 140
G + R G Y CVA N G A E+++L D +
Sbjct: 1028 QGQSLHVE----RAQAAHTGRYSCVAENLAGRA---ERKFELSVLVPPELIGDLDPLTNI 1080
Query: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGG-KLMITYTRKSDAGKY 199
A+ P + C+ G P P I W + P+ ++ + GG L +T T++ D+G Y
Sbjct: 1081 TAALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLY 1139
Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD--SAEFKCEARGDPVPTVRWR 257
C+ +N GE + + VL PS + V D +A C G P P + W
Sbjct: 1140 SCLASNEAGEARRNFS-VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWF 1198
Query: 258 KDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
KD L + + + D L++ + G Y+C+A N VG+ L+V P +
Sbjct: 1199 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTIL 1258
Query: 316 VKPRDQV-----VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 370
D V + ++ CEA P P I W ++G+ P ++S +
Sbjct: 1259 GGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--------PFEASRNIQLLP 1310
Query: 371 -TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT--- 426
T L I N Q+ D G Y C N G + ++EV PP + + P+ +
Sbjct: 1311 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI-----PPSISKDDPLAEVGVK 1365
Query: 427 ---VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTG 482
V+ T L C + P PTI W KDG V T SR++ L G +LQI+ ++ D+G
Sbjct: 1366 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLGEGRLLQIQPTQVSDSG 1424
Query: 483 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 542
RY C+A+ +GE + Q+F V +Q P P +V D S LS
Sbjct: 1425 RYLCVATNVAGE-------DDQDFNVLIQVP-----------PMFQKVGDFSAAFEILSR 1466
Query: 543 QPNLNSGATPTSYIIE 558
+ G T I+E
Sbjct: 1467 EEEARGGVTEYREIVE 1482
Score = 162 bits (410), Expect = 2e-39
Identities = 150/519 (28%), Positives = 216/519 (41%), Gaps = 69/519 (13%)
Query: 28 PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP I + ++ G+ A L C G P P + W+K G + +H + P
Sbjct: 1161 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 1215
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH---NASLEVAILRDDFRQNPSDVMV 142
G L L+++ S G Y C+A N +GE H + L IL +V V
Sbjct: 1216 GVL--LQVLQANLS--SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 1271
Query: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVC 201
V P + C+ P P I+W KDG+P + + G L I +K DAG+Y C
Sbjct: 1272 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 1330
Query: 202 VGTNMVGERESEVAELTVLERPSFVKRP-------SNLAVTVDDSAEFKCEARGDPVPTV 254
V TN +GE + VL PS K + V+ + +CE+ P PT+
Sbjct: 1331 VVTNELGEAVKNY-HVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTI 1389
Query: 255 RWRKDDGEL-PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
RW KD + P SR ++ + L+I+ D G Y CVA N+ G+ + + +Q PP
Sbjct: 1390 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1449
Query: 313 HFV----------VKPRDQVVALGRT----------VTFQCEATGNPQPAIFWRREGSQN 352
F + R++ G T C+ P P + W RE
Sbjct: 1450 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED--- 1506
Query: 353 LLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 411
QP + SV Q G L I V+ + G Y C+ N G L V
Sbjct: 1507 -----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 1558
Query: 412 DRPPPVIRQGPVNQ-----TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 466
PPVI G + TV T L C A G+PVPTI W ++G L + R++ L
Sbjct: 1559 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-LPFSPSPRLQVL 1613
Query: 467 ENG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
E+G VLQ+ A++ D Y C+A +G A + VQ
Sbjct: 1614 EDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 1652
Score = 162 bits (409), Expect = 3e-39
Identities = 129/472 (27%), Positives = 192/472 (40%), Gaps = 45/472 (9%)
Query: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLPSGSLFFLRIVHG 96
+ + PA L C P P + WY+ +D P S +L G + + +V
Sbjct: 1480 IVENNPAYLYCDTNAIPPPDLTWYR--------EDQPLSAGDEVSVLQGGRVLQIPLVRA 1531
Query: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVA--ILRDDFRQNPSDVMVAVGEPAVMECQP 154
+ G Y C A N +GE H L + ++ D + +V V ++C P
Sbjct: 1532 ENA----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-P 1586
Query: 155 PRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESE 213
G+P PTISW ++G P + G+ L ++ +DA Y+CV N G E +
Sbjct: 1587 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE-K 1645
Query: 214 VAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR--YEI 270
+ L V P + ++ S C+ P P V W KD L + +
Sbjct: 1646 LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL 1705
Query: 271 RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ----VVALG 326
HTL++ + D G YTC A N G+ + L+V PP F PR +V +G
Sbjct: 1706 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 1765
Query: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVG 385
CE P+P + W ++G QP + R + G L I Q SD G
Sbjct: 1766 DKAVLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVSDKG 1817
Query: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCVATGSP 443
Y C+ NVAG + L V + PP + P +TV+ VL+C +G P
Sbjct: 1818 LYSCKVSNVAGEAVRTFTLTV------QVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVP 1870
Query: 444 VPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 495
PT+ W KD + V + G LQ+ + G YTC+A EA
Sbjct: 1871 APTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 1922
Score = 160 bits (405), Expect = 9e-39
Identities = 144/505 (28%), Positives = 204/505 (40%), Gaps = 48/505 (9%)
Query: 28 PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERV-----------ETDKD 74
PP I E VS G+ TL C A G P P I W K + V +
Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75
Query: 75 DPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFR 134
HR+L SL F RI G D G+Y C A N G A L +
Sbjct: 76 QVGGHRLLDEGQSLHFPRIQEG-----DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 130
Query: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIR--GGKLMITYTR 192
+V+ G ++C G P P + W KD P+ + ++ G L IT +
Sbjct: 131 GAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSH 189
Query: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSF--VKRPSNLAVTVDDSAEFKCEARGDP 250
D G+Y CV + G++ + +L V P+ +AV D + CEARG P
Sbjct: 190 VGDEGRYQCVAFSPAGQQARDF-QLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP 248
Query: 251 VPTVRWRKDDGELPKSRYEI--RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
P + W KD LP S + R L++ + + D G YTC A N VG AE + L V
Sbjct: 249 TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 308
Query: 309 QEPPHFVV---KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 365
PP +P GR V +C A G+P P + W EG P S+
Sbjct: 309 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGL--------PVAESNE 360
Query: 366 FSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP--VIRQGP 422
+ G L + + + G Y C + AG + + +EV + PP ++ +G
Sbjct: 361 SRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV------QVPPQLLVAEGL 414
Query: 423 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTG 482
T V L C A+GSPVPTI W ++G + L I + +L +G
Sbjct: 415 GQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSG 474
Query: 483 RYTCIASTPSGEATWSAYIEVQEFG 507
+ C A+ +G A A +EV G
Sbjct: 475 LFACQATNEAGTA--GAEVEVSVHG 497
Score = 155 bits (393), Expect = 2e-37
Identities = 148/534 (27%), Positives = 216/534 (40%), Gaps = 43/534 (8%)
Query: 28 PPRI--VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP I ++ V + L C+A G PTP I W+K G + P S +++
Sbjct: 218 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL------PTSTKVVYTR 271
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVMVAV 144
G ++ GR D GVY C A N +G A + + V + P V
Sbjct: 272 GGR---QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 328
Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVG 203
G P +EC RGHP PT+SW +G P+ + +E R+ G L + ++ +G Y CV
Sbjct: 329 GRPVALECVA-RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 387
Query: 204 TNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD-- 260
++ GE + + E+ V + + + V E C+A G PVPT++W ++
Sbjct: 388 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 447
Query: 261 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QEPPHFVVKP 318
E TL I V G + C A N G A A ++V + P + P
Sbjct: 448 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVP 507
Query: 319 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS------SSRFSVSQTG 372
Q G A +P W L+ + P S + S
Sbjct: 508 IGQY-HWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPP 566
Query: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 432
L I V D G Y C N+AG + L+V PP I GPVN+ V + +
Sbjct: 567 PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL------VPPNIEPGPVNKAVLENAS 620
Query: 433 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 492
L C+A+G P P + W K VS+ ++ VL+I A+L D G Y C+AS +
Sbjct: 621 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 680
Query: 493 GEATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 545
G +G+ V PPR T P PS P V R T + P+
Sbjct: 681 GSTE-------LRYGLRVNVPPRITLP---PSLPGPVLVNTPVRLTCNATGAPS 724
Score = 153 bits (387), Expect = 1e-36
Identities = 148/519 (28%), Positives = 212/519 (40%), Gaps = 71/519 (13%)
Query: 32 VEHPSDLIVSKG---------EPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
V+ P L+V++G +P L C+A G P PTI+W + G E + +
Sbjct: 402 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE-----LAGVQV 456
Query: 83 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
G+ + V S G++ C A N G A A +EV++ + P + V
Sbjct: 457 ASQGTTLHIDHVELDHS----GLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLEV 506
Query: 143 AVGE-----------PAVMECQPP--RG---HPEPTI--SWKKDGSPLDDKDERITIRGG 184
+G+ PA C PP RG HP+P + W GS L + I +
Sbjct: 507 PIGQYHWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 563
Query: 185 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
L I D G Y C TN+ GE + EVA L VL P+ P N AV + S
Sbjct: 564 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVT 622
Query: 242 FKCEARGDPVPTVRWRKDDGELPKSRY----EIRDDHTLKIRKVTAGDMGSYTCVAENMV 297
+C A G P P V W K G P S + D L+I + D GSY CVA N+
Sbjct: 623 LECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 680
Query: 298 GKAEASATLTVQEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 356
G E L V PP + P V + V C ATG P P + W ++G+
Sbjct: 681 GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP----- 735
Query: 357 YQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 415
P + V G LT+ + + SD G Y C ++ G L+V P
Sbjct: 736 -VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------HMP 788
Query: 416 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 475
P I +N +V + + L C + P P + W KDG + + + +LQ+
Sbjct: 789 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDR 848
Query: 476 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 514
A + D G YTC A +G + + + + PV P R
Sbjct: 849 ADVWDAGHYTCEALNQAGHS--EKHYNLNVWVAPVFPLR 885
Score = 142 bits (358), Expect = 3e-33
Identities = 121/456 (26%), Positives = 190/456 (41%), Gaps = 35/456 (7%)
Query: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
DEG+Y C A N GE+ +L+V ++ + P + V +EC G P P
Sbjct: 577 DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECLAS-GVPPP 633
Query: 162 TISWKKDGSPLDD-KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
+SW K P+ +++ G L I + SDAG Y CV +N+ G E L V
Sbjct: 634 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-LRVN 692
Query: 221 ERPSFVKRPSNLA-VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHT 275
P PS V V+ C A G P PT+ W KD + +
Sbjct: 693 VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV 752
Query: 276 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA 335
L + A D G Y+CVA + VG+ L V PP + + + V +V +C++
Sbjct: 753 LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQS 812
Query: 336 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV---GYYICQTL 392
P P + W ++G R V + D + V R+DV G+Y C+ L
Sbjct: 813 HAMPPPVLSWWKDGRP----------LEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 862
Query: 393 NVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD 452
N AG ++ + + +A P +R+ TV LSC G P P I WRKD
Sbjct: 863 NQAGH--SEKHYNLNVWVAPVFP--LRESHT-LTVREGHPTRLSCECRGVPFPKISWRKD 917
Query: 453 GVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ---EFG 507
G + + + ++ + +L + A+L G YTC S G ++ +EV +
Sbjct: 918 GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 977
Query: 508 VPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 543
P +P PT +++ + E + T++W+
Sbjct: 978 GPREP--PTQVSVVQDGVATLECNATGKPPPTVTWE 1011
Score = 132 bits (331), Expect = 4e-30
Identities = 94/281 (33%), Positives = 129/281 (45%), Gaps = 19/281 (6%)
Query: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
P D + G+ L C A G PTP I W T D P + + G R
Sbjct: 2853 PGDRSLRLGDRLWLRCAARGSPTPRIGW--------TVNDRPVTEGVSEQDGGSTLQRAA 2904
Query: 95 HGRKSRPDEGVYVCVARNYLG--EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152
SR D G YVC A N +G +AVS E +L+ + S ++ VG ++C
Sbjct: 2905 ---VSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF---SYLVEPVGGSIQLDC 2958
Query: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
RG P P I W KDG PL R ++ G L I T + DAG+Y C+ N +G +
Sbjct: 2959 VV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAK- 3016
Query: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR-YEIR 271
+V L + P F P ++ V D +C+A G+P PT+ W + L SR
Sbjct: 3017 KVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTL 3076
Query: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
D +L + V GD G+Y CVA N++G A A A L V+ P
Sbjct: 3077 PDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117
Score = 125 bits (313), Expect = 4e-28
Identities = 120/414 (28%), Positives = 172/414 (41%), Gaps = 41/414 (9%)
Query: 116 EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKD----GSP 171
E + + S+ +R+D R+ ++V G+ +EC G P P I W KD G P
Sbjct: 6 EPLLNTGSVVPPSIREDGRK--ANVSGMAGQSLTLECDA-NGFPVPEIVWLKDAQLVGVP 62
Query: 172 L------------DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
L R+ G L ++ D+G Y C N G + + L V
Sbjct: 63 LGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDF-HLLV 121
Query: 220 LERPSFVKRPSNLAVT--VDDSAEFKCEARGDPVPTVRWRKD-DGELPKSRY-EIRDD-H 274
L PS + + V E +C G P P V W KD LP + ++++D
Sbjct: 122 LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ 181
Query: 275 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL--GRTVTFQ 332
L+I GD G Y CVA + G+ L V PP VA+ V
Sbjct: 182 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLL 241
Query: 333 CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTL 392
CEA G P P I W ++G+ LL P S+ L + Q SD G Y C+
Sbjct: 242 CEARGVPTPNITWFKDGA--LL-----PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKAS 294
Query: 393 NVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV-AVDGTFV-LSCVATGSPVPTILWR 450
N G+ L+V PP + G V AV G V L CVA G P PT+ W
Sbjct: 295 NAVGAAEKATRLDVYV-----PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWH 349
Query: 451 KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
+G+ V+ + + + VL++ +G Y+C+AS+P+GEA +EVQ
Sbjct: 350 HEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ 403
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 208 bits (529), Expect = 4e-53
Identities = 149/478 (31%), Positives = 215/478 (44%), Gaps = 31/478 (6%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
P + PS + E L C+A G P PTI W K G V T +LP G L
Sbjct: 2757 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 2811
Query: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
RI H S D G Y+C+A+N G A+ V + D+ G A
Sbjct: 2812 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 2864
Query: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMV 207
+ C+ RG PEP I+W KDG P+ + + TI+ G+L++ DAG Y C N V
Sbjct: 2865 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2923
Query: 208 GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR 267
G V LT+L P F P + ++ + D +C ARG P P + W +D + +
Sbjct: 2924 GRARRRV-HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2982
Query: 268 YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA-LG 326
E TL+ V+ D G+Y C AEN VG+ +A + + V+E P + +V +G
Sbjct: 2983 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVG 3042
Query: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 386
++ C G+P P I W ++G P + S Q G LTI +R D G
Sbjct: 3043 GSIQLDCVVRGDPVPDIHWIKDGL--------PLRGSHLRHQLQNGSLTIHRTERDDAGR 3094
Query: 387 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 446
Y C N G + K + ++ + PV + P + TV L C ATG P PT
Sbjct: 3095 YQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT 3148
Query: 447 ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
I W + G + R++ L +G L + + GD G Y C+A G AT A++ V+
Sbjct: 3149 IEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3205
Score = 194 bits (493), Expect = 6e-49
Identities = 154/500 (30%), Positives = 220/500 (44%), Gaps = 40/500 (8%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
P I P + VS + A L C+A+G P P + W K +RV D PR +LP GSL
Sbjct: 2482 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK--DRVPLDPRSPRFE--ILPEGSL 2537
Query: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-FRQNPSDVMVAVGEP 147
++ D G Y+C+A N G S ++ +L +PS++ + P
Sbjct: 2538 RIQPVL-----AQDAGHYLCLASNSAG---SDRQGRDLRVLEPPAIAPSPSNLTLTAHTP 2589
Query: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIR---GGKLMITYTRKSDAGKYVCVGT 204
A++ C+ G P+P + W KDG LD + ++ R L++T D+ ++ CV +
Sbjct: 2590 ALLPCEAS-GSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVS 2648
Query: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
N VGE + ++TV P+ ++ VT+ C + G P PTV W K +L
Sbjct: 2649 NEVGEAH-RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG 2707
Query: 265 K--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV 322
S Y + L+I + G YTC A N G A LTVQ P VVKP V
Sbjct: 2708 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP--VVKPLPSV 2765
Query: 323 V--ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
V V CEA+G P+P I W++EG + V G L I +
Sbjct: 2766 VRAVAEEEVLLPCEASGIPRPTITWQKEGLN--------VATGVSTQVLPGGQLRIAHAS 2817
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 440
D G Y+C N AGS + K L V + PPVI G + + L C A
Sbjct: 2818 PEDAGNYLCIAKNSAGSAMGKTRLVV------QVPPVIENGLPDLSTTEGSHAFLPCKAR 2871
Query: 441 GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 500
GSP P I W KDG VS + + +G L ++ + D G YTC A G A +
Sbjct: 2872 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 2931
Query: 501 IEVQEFGVPVQPPRPTDPNL 520
+ + +PV P D +L
Sbjct: 2932 LTI--LVLPVFTTLPGDRSL 2949
Score = 192 bits (489), Expect = 2e-48
Identities = 158/510 (30%), Positives = 222/510 (43%), Gaps = 49/510 (9%)
Query: 28 PPRI---VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
PP I + L+ GE T+ C G P + W K G + P S R LL
Sbjct: 2119 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 2171
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVM 141
GS LRI + D G++ CVA + G A N +L+V + L QN DV+
Sbjct: 2172 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 2226
Query: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201
V G + C+ RG P P +SW KDG PL + +G L + D+G Y C
Sbjct: 2227 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 2282
Query: 202 VGTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
V + GE +LTV+E P +P+ L++T E C+A+G P P + W KD
Sbjct: 2283 VAVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 2341
Query: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
L + R L++R D G YTC+AE+ G E S + VQ PP+ +V PR
Sbjct: 2342 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPN-IVGPR 2395
Query: 320 DQVVALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 376
+G + +C P P I W R+G ++ RF L +
Sbjct: 2396 GPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF-------LQL 2448
Query: 377 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 436
+ +D G Y C N AGS +E+ V P IR GP V+V+ T +L
Sbjct: 2449 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALLP 2502
Query: 437 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 496
C A G P P + WRKD V + + R + L G L+I+ D G Y C+AS +G
Sbjct: 2503 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 2562
Query: 497 WSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 526
+ V E P P P++ L P+
Sbjct: 2563 QGRDLRVLE--PPAIAPSPSNLTLTAHTPA 2590
Score = 186 bits (472), Expect = 2e-46
Identities = 156/542 (28%), Positives = 231/542 (42%), Gaps = 56/542 (10%)
Query: 28 PPRIVE--HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP I + P++L ++ G P L C A+G P P I W+K G+ + +++ R+ R+L
Sbjct: 2302 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 2361
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
D G+Y C+A + G S V + P VG
Sbjct: 2362 ----------------DAGLYTCLAESPAGAI---EKSFRVRVQAPPNIVGPRGPRFVVG 2402
Query: 146 ---EPAVMECQPPRGHPEPTISWKKDGSPL-DDKDERITIRGGKLMITYTRKSDAGKYVC 201
V+EC P P I+W +DG L +D + RG L + +D+G Y C
Sbjct: 2403 LAPGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSC 2461
Query: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
N G S + + P+ P + V+V+ +A C+A G P P V WRKD
Sbjct: 2462 TARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRV 2520
Query: 262 EL-PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
L P+S R+EI + +L+I+ V A D G Y C+A N G L V EPP P
Sbjct: 2521 PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 2580
Query: 320 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 379
+ + CEA+G+P+P + W ++G Q L F Q + + + L +T
Sbjct: 2581 NLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLLTAP 2635
Query: 380 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 439
D + C N G + Y V PP I + TV + VL+C +
Sbjct: 2636 GPQDSAQFECVVSNEVGE-AHRLYQVTVHV-----PPTIADDQTDFTVTMMAPVVLTCHS 2689
Query: 440 TGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 499
TG P PT+ W K G + + S + +G L+I A GRYTC A +G A
Sbjct: 2690 TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHV 2749
Query: 500 YIEVQEFGVPVQPPRPT-------DPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 552
++ VQ PV P P+ + L+P E + + R T+T WQ + AT
Sbjct: 2750 FLTVQ--ASPVVKPLPSVVRAVAEEEVLLPC-----EASGIPRPTIT--WQKEGLNVATG 2800
Query: 553 TS 554
S
Sbjct: 2801 VS 2802
Score = 184 bits (466), Expect = 8e-46
Identities = 168/527 (31%), Positives = 234/527 (44%), Gaps = 71/527 (13%)
Query: 47 TLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVY 106
TL C++ P PTI WYK G+ V P S +L G L L+I + S D G Y
Sbjct: 1467 TLECESWAVPPPTIRWYKDGQPVT-----PSSRLQVLGEGRL--LQIQPTQVS--DSGRY 1517
Query: 107 VCVARNYLGE-----------------AVSHNASLEVAILRDDFRQNPSDVMVAV-GEPA 148
+CVA N GE +A+ E+ ++ R ++ V PA
Sbjct: 1518 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1577
Query: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMV 207
+ C P P ++W ++ PL DE ++GG+ L I R +AG+Y C +N V
Sbjct: 1578 YLYCDT-NAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEV 1636
Query: 208 GERESEVAELTVLERPSFVKRPSNLA--VTVDDSA--EFKCEARGDPVPTVRWRKDDGEL 263
GE EL VL P + L VTV+ S+ +C A G+PVPT+ W ++
Sbjct: 1637 GEDWLHY-ELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPF 1695
Query: 264 -PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 321
P R ++ +D L++ D SY CVAEN G AE TL VQ PP +Q
Sbjct: 1696 SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQ 1755
Query: 322 VVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
V A L +V+ C+ +P P + W ++ SQ L + F + T L + +
Sbjct: 1756 VTAILNSSVSLPCDVHAHPNPEVTWYKD-SQALSLGEEV------FLLPGTHTLQLGRAR 1808
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ----TVAVDGTFVLS 436
SD G Y C+ LN AG L V PP RQ P V V VLS
Sbjct: 1809 LSDSGMYTCEALNAAGRDQKLVQLSVL------VPPAFRQAPRGPQDAVLVRVGDKAVLS 1862
Query: 437 CVATGSPVPTILWRKDG-VLVSTQDSRIKQLENGV-LQIRYAKLGDTGRYTCIASTPSGE 494
C P PT+ W KDG LV Q R + L G L+I+ A++ D G Y+C S +GE
Sbjct: 1863 CETDALPEPTVTWYKDGQPLVLAQ--RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1920
Query: 495 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 541
A V+ F + VQ P PT N P V+ V+ + + L+
Sbjct: 1921 A-------VRTFTLTVQVP-PTFEN-----PKTETVSQVAGSPLVLT 1954
Score = 183 bits (465), Expect = 1e-45
Identities = 145/478 (30%), Positives = 204/478 (42%), Gaps = 34/478 (7%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP I P + V + TL C A G P P + W+KG + V S + S
Sbjct: 694 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 746
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
LRI + S D G Y CVA N G + L V + V V P
Sbjct: 747 GRVLRIEQAQLS--DAGSYRCVASNVAG-STELRYGLRVNVPPRITLPPSLPGPVLVNTP 803
Query: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDE---RITIRGGKLMITYTRKSDAGKYVCVGT 204
+ C G P PT+ W KDG+P+ ++ G L + R SD+G+Y CV
Sbjct: 804 VRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 862
Query: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL- 263
+ VGE +V L V PS + N++V ++S +C++ P P + W KD L
Sbjct: 863 SAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 921
Query: 264 PKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV 322
P+ + D L ++ + D G YTC A N G++E L V P F ++ +
Sbjct: 922 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTL 981
Query: 323 -VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQ 380
V G + CE G P P I WR++G P + + VS G L + Q
Sbjct: 982 TVREGHPTSLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQAQ 1035
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI---RQGPVNQTVAVDGTFVLSC 437
+ G Y C+ NV G+ LEV PP I R+ P +V DG L C
Sbjct: 1036 LAQEGTYTCECSNVVGNSSQDLQLEV------HVPPQIAGPREPPTQVSVVQDGVATLEC 1089
Query: 438 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 495
ATG P PT+ W +DG V + Q + L + A+ TGRY+C+A +G A
Sbjct: 1090 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1147
Score = 178 bits (451), Expect = 4e-44
Identities = 142/515 (27%), Positives = 215/515 (41%), Gaps = 41/515 (7%)
Query: 1 MIAEPAHFYLFGLICLCS---GSRLRQEDF----PPRIVEHPSDLIVSKGEPATLNCKAE 53
++A+ A YL CL S GS + D PP I PS+L ++ PA L C+A
Sbjct: 2542 VLAQDAGHYL----CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 2597
Query: 54 GRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNY 113
G P P + W+K G++++ + LLPS +L D + CV N
Sbjct: 2598 GSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNALLLTA-----PGPQDSAQFECVVSNE 2650
Query: 114 LGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD 173
+GEA H + + +D V + P V+ C G P PT+SW K G+ L
Sbjct: 2651 VGEA--HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHST-GIPAPTVSWSKAGAQLG 2707
Query: 174 DKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNL 232
+ + G L I AG+Y C N G V LTV P PS +
Sbjct: 2708 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF-LTVQASPVVKPLPSVV 2766
Query: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTC 291
++ CEA G P PT+ W+K+ + ++ L+I + D G+Y C
Sbjct: 2767 RAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC 2826
Query: 292 VAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 351
+A+N G A L VQ PP D G C+A G+P+P I W ++G
Sbjct: 2827 IAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDG-- 2884
Query: 352 NLLFSYQPPQSSS-RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 410
QP + +F++ +G+L + N++ D G Y C N G + +L + +
Sbjct: 2885 ------QPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL- 2937
Query: 411 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 470
PV P ++++ + L C A GSP P I W + V+ S +Q
Sbjct: 2938 -----PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS--EQDGGST 2990
Query: 471 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 505
LQ D+G Y C A G +++ V+E
Sbjct: 2991 LQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE 3025
Score = 177 bits (449), Expect = 7e-44
Identities = 146/489 (29%), Positives = 212/489 (43%), Gaps = 44/489 (8%)
Query: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Q PP I+ ++ V E L C++ P P + W+K G +E PR L
Sbjct: 875 QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 929
Query: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 143
+L + R D G Y C A N G + H +L V + + + V
Sbjct: 930 ADKALLQV----DRADVWDAGHYTCEALNQAGRSEKH-YNLNVWVAPVFPLRESHTLTVR 984
Query: 144 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD---ERITIRGGKLMITYTRKSDAGKYV 200
G P + C+ RG P P ISW+KDG PL + + ++ G L + + + G Y
Sbjct: 985 EGHPTSLSCE-CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 1043
Query: 201 CVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
C +N+VG S+ +L V P + P+ ++V D A +C A G P PTV W
Sbjct: 1044 CECSNVVG-NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE 1102
Query: 258 KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHF 314
+ DG+ + ++ +L + + A G Y+CVAEN+ G+AE L+V PP
Sbjct: 1103 R-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1161
Query: 315 V--VKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
+ + P + AL +T CEA G P PAI W F + P S +
Sbjct: 1162 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW---------FRGEEPVSPGEDTYLLA 1212
Query: 372 GD--LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 429
G L +T Q D G Y C N AG +EV PP I + + + V
Sbjct: 1213 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEVIKV 1266
Query: 430 -DG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 487
DG T L C TG P P + W KDG ++ D+ + +LQ+ A L G Y+CI
Sbjct: 1267 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1326
Query: 488 ASTPSGEAT 496
A+ GE T
Sbjct: 1327 AANAVGEKT 1335
Score = 177 bits (449), Expect = 7e-44
Identities = 158/512 (30%), Positives = 225/512 (43%), Gaps = 58/512 (11%)
Query: 35 PSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
P D ++V G+ A L+C+ + P PT+ WYK G+ + L G L I
Sbjct: 1847 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL-----AQRTQALRGGQR--LEI 1899
Query: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153
+ S D+G+Y C N GEAV +L V + V G P V+ C
Sbjct: 1900 QEAQVS--DKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 1956
Query: 154 PPRGHPEPTISWKKDGSPLDDKD-ERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
G P PT++W KD P++ + RGG+L ++ + + AG Y CV N E
Sbjct: 1957 -VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 2015
Query: 213 EVAELTVLERPSFVKRPSNLA----VTVDDSAEFKCEARGDPVPTVRWRKDDGEL----- 263
+ + VL P R S +A V CEA G P P V W KD L
Sbjct: 2016 DFV-VAVLVAPRI--RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 2072
Query: 264 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV 323
P R+ + D +L ++ + A D G+YTCVA N G+ T+ V PP + + D
Sbjct: 2073 PHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPP-TIKQGADGSG 2130
Query: 324 AL----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITN 378
L G VT C G+P + W ++G P S R + +G L I+
Sbjct: 2131 TLVSRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISK 2182
Query: 379 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV---NQTVAVDGTFV- 434
VQ +D G + C + AG L+V + PPV+ PV N V V G+ V
Sbjct: 2183 VQLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLE--PVEFQNDVVVVRGSLVE 2234
Query: 435 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSG 493
L C A G P+P + W KDG + +Q LE G LQ+ GD+G Y+C+A + +G
Sbjct: 2235 LPCEARGVPLPLVSWMKDGEPLLSQ-----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAG 2289
Query: 494 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 525
EA + V E +PT+ +L P AP
Sbjct: 2290 EARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 2321
Score = 173 bits (438), Expect = 1e-42
Identities = 152/556 (27%), Positives = 231/556 (41%), Gaps = 71/556 (12%)
Query: 28 PPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
PP+I E P+ + V + ATL C A G+P PT+ W + G+ V + L
Sbjct: 1064 PPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG-----LQLQN 1118
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD----V 140
G + R G Y CVA N G A E+++L D +
Sbjct: 1119 QGQSLHVE----RAQAAHTGRYSCVAENLAGRA---ERKFELSVLVPPELIGDLDPLTNI 1171
Query: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGG-KLMITYTRKSDAGKY 199
A+ P + C+ G P P I W + P+ ++ + GG L +T T++ D+G Y
Sbjct: 1172 TAALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLY 1230
Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD--SAEFKCEARGDPVPTVRWR 257
C+ +N GE + + VL PS + V D +A C G P P + W
Sbjct: 1231 SCLASNEAGEARRNFS-VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWF 1289
Query: 258 KDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
KD L + + + D L++ + G Y+C+A N VG+ L+V P +
Sbjct: 1290 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTIL 1349
Query: 316 VKPRDQV-----VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 370
D V + ++ CEA P P I W ++G+ P ++S +
Sbjct: 1350 GGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--------PFEASRNIQLLP 1401
Query: 371 -TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT--- 426
T L I N Q+ D G Y C N G + ++EV PP + + P+ +
Sbjct: 1402 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI-----PPSISKDDPLGEVGVK 1456
Query: 427 ---VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTG 482
V+ T L C + P PTI W KDG V T SR++ L G +LQI+ ++ D+G
Sbjct: 1457 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLGEGRLLQIQPTQVSDSG 1515
Query: 483 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 542
RY C+A+ +GE + Q+F V +Q P P +V D S LS
Sbjct: 1516 RYLCVATNVAGE-------DDQDFNVLIQVP-----------PMFQKVGDFSAAFEILSR 1557
Query: 543 QPNLNSGATPTSYIIE 558
+ G T I+E
Sbjct: 1558 EEEARGGVTEYREIVE 1573
Score = 171 bits (434), Expect = 4e-42
Identities = 126/385 (32%), Positives = 175/385 (45%), Gaps = 32/385 (8%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP I DL ++G A L CKA G P P I W K G+ V + PSG
Sbjct: 2846 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS----GAEGKFTIQPSGE 2901
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
L ++ + G+ D G Y C A N +G A L + +L F P D + +G+
Sbjct: 2902 LL-VKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 2954
Query: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
+ C RG P P I W + P+ + G L + D+G YVC N V
Sbjct: 2955 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQD-GGSTLQRAAVSREDSGTYVCWAENRV 3012
Query: 208 GERES----EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 263
G ++ V E VL+ +F S L V S + C RGDPVP + W KD L
Sbjct: 3013 GRTQAVSFVHVKEAPVLQGEAF----SYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 3068
Query: 264 PKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 321
S R+++++ +L I + D G Y C+AEN +G A+ L +Q P F V+P+D
Sbjct: 3069 RGSHLRHQLQNG-SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM 3127
Query: 322 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 381
V G V +C+ATG P P I W + G QP ++S R G L + NV+
Sbjct: 3128 TVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLENVET 3179
Query: 382 SDVGYYICQTLNVAGSIITKAYLEV 406
D G Y C N+ GS +A+L V
Sbjct: 3180 GDAGTYDCVAHNLLGSATARAFLVV 3204
Score = 162 bits (410), Expect = 2e-39
Identities = 150/519 (28%), Positives = 216/519 (41%), Gaps = 69/519 (13%)
Query: 28 PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP I + ++ G+ A L C G P P + W+K G + +H + P
Sbjct: 1252 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 1306
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH---NASLEVAILRDDFRQNPSDVMV 142
G L L+++ S G Y C+A N +GE H + L IL +V V
Sbjct: 1307 GVL--LQVLQANLS--SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 1362
Query: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVC 201
V P + C+ P P I+W KDG+P + + G L I +K DAG+Y C
Sbjct: 1363 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 1421
Query: 202 VGTNMVGERESEVAELTVLERPSFVKRP-------SNLAVTVDDSAEFKCEARGDPVPTV 254
V TN +GE + VL PS K + V+ + +CE+ P PT+
Sbjct: 1422 VVTNELGEAVKNY-HVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTI 1480
Query: 255 RWRKDDGEL-PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
RW KD + P SR ++ + L+I+ D G Y CVA N+ G+ + + +Q PP
Sbjct: 1481 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1540
Query: 313 HFV----------VKPRDQVVALGRT----------VTFQCEATGNPQPAIFWRREGSQN 352
F + R++ G T C+ P P + W RE
Sbjct: 1541 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED--- 1597
Query: 353 LLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 411
QP + SV Q G L I V+ + G Y C+ N G L V
Sbjct: 1598 -----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 1649
Query: 412 DRPPPVIRQGPVNQ-----TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 466
PPVI G + TV T L C A G+PVPTI W ++G L + R++ L
Sbjct: 1650 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-LPFSPSPRLQVL 1704
Query: 467 ENG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
E+G VLQ+ A++ D Y C+A +G A + VQ
Sbjct: 1705 EDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 1743
Score = 162 bits (409), Expect = 3e-39
Identities = 129/472 (27%), Positives = 192/472 (40%), Gaps = 45/472 (9%)
Query: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLPSGSLFFLRIVHG 96
+ + PA L C P P + WY+ +D P S +L G + + +V
Sbjct: 1571 IVENNPAYLYCDTNAIPPPDLTWYR--------EDQPLSAGDEVSVLQGGRVLQIPLVRA 1622
Query: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVA--ILRDDFRQNPSDVMVAVGEPAVMECQP 154
+ G Y C A N +GE H L + ++ D + +V V ++C P
Sbjct: 1623 ENA----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-P 1677
Query: 155 PRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESE 213
G+P PTISW ++G P + G+ L ++ +DA Y+CV N G E +
Sbjct: 1678 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE-K 1736
Query: 214 VAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR--YEI 270
+ L V P + ++ S C+ P P V W KD L + +
Sbjct: 1737 LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL 1796
Query: 271 RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ----VVALG 326
HTL++ + D G YTC A N G+ + L+V PP F PR +V +G
Sbjct: 1797 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 1856
Query: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVG 385
CE P+P + W ++G QP + R + G L I Q SD G
Sbjct: 1857 DKAVLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVSDKG 1908
Query: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCVATGSP 443
Y C+ NVAG + L V + PP + P +TV+ VL+C +G P
Sbjct: 1909 LYSCKVSNVAGEAVRTFTLTV------QVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVP 1961
Query: 444 VPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 495
PT+ W KD + V + G LQ+ + G YTC+A EA
Sbjct: 1962 APTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 2013
Score = 155 bits (393), Expect = 2e-37
Identities = 148/534 (27%), Positives = 216/534 (40%), Gaps = 43/534 (8%)
Query: 28 PPRI--VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP I ++ V + L C+A G PTP I W+K G + P S +++
Sbjct: 309 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL------PTSTKVVYTR 362
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVMVAV 144
G ++ GR D GVY C A N +G A + + V + P V
Sbjct: 363 GGR---QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 419
Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVG 203
G P +EC RGHP PT+SW +G P+ + +E R+ G L + ++ +G Y CV
Sbjct: 420 GRPVALECVA-RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 478
Query: 204 TNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD-- 260
++ GE + + E+ V + + + V E C+A G PVPT++W ++
Sbjct: 479 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 538
Query: 261 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QEPPHFVVKP 318
E TL I V G + C A N G A A ++V + P + P
Sbjct: 539 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVP 598
Query: 319 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS------SSRFSVSQTG 372
Q G A +P W L+ + P S + S
Sbjct: 599 IGQY-HWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPP 657
Query: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 432
L I V D G Y C N+AG + L+V PP I GPVN+ V + +
Sbjct: 658 PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL------VPPNIEPGPVNKAVLENAS 711
Query: 433 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 492
L C+A+G P P + W K VS+ ++ VL+I A+L D G Y C+AS +
Sbjct: 712 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 771
Query: 493 GEATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 545
G +G+ V PPR T P PS P V R T + P+
Sbjct: 772 GSTE-------LRYGLRVNVPPRITLP---PSLPGPVLVNTPVRLTCNATGAPS 815
Score = 153 bits (387), Expect = 1e-36
Identities = 149/519 (28%), Positives = 212/519 (40%), Gaps = 71/519 (13%)
Query: 32 VEHPSDLIVSKG---------EPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
V+ P L+V++G +P L C+A G P PTI+W + G E + +
Sbjct: 493 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAE-----ELAGVQV 547
Query: 83 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
G+ L I H G++ C A N G A A +EV++ + P + V
Sbjct: 548 ASQGTT--LHIDHVELDH--SGLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLEV 597
Query: 143 AVGE-----------PAVMECQPP--RG---HPEPTI--SWKKDGSPLDDKDERITIRGG 184
+G+ PA C PP RG HP+P + W GS L + I +
Sbjct: 598 PIGQYHWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 654
Query: 185 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
L I D G Y C TN+ GE + EVA L VL P+ P N AV + S
Sbjct: 655 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVT 713
Query: 242 FKCEARGDPVPTVRWRKDDGELPKSRY----EIRDDHTLKIRKVTAGDMGSYTCVAENMV 297
+C A G P P V W K G P S + D L+I + D GSY CVA N+
Sbjct: 714 LECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 771
Query: 298 GKAEASATLTVQEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 356
G E L V PP + P V + V C ATG P P + W ++G+
Sbjct: 772 GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP----- 826
Query: 357 YQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 415
P + V G LT+ + + SD G Y C ++ G L+V P
Sbjct: 827 -VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------HMP 879
Query: 416 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 475
P I +N +V + + L C + P P + W KDG + + + +LQ+
Sbjct: 880 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDR 939
Query: 476 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 514
A + D G YTC A +G + + + + PV P R
Sbjct: 940 ADVWDAGHYTCEALNQAGRS--EKHYNLNVWVAPVFPLR 976
Score = 146 bits (369), Expect = 1e-34
Identities = 142/524 (27%), Positives = 203/524 (38%), Gaps = 73/524 (13%)
Query: 28 PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERV-----------ETDKD 74
PP I E VS G+ TL C A G P P I W K + V +
Sbjct: 94 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 153
Query: 75 DPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFR 134
HR+L SL F RI GR R G + A + F
Sbjct: 154 QVGGHRLLDEGQSLHFPRIQPGRSGRRGAQA---------GGSAQTKAPWXAGLA--GFE 202
Query: 135 QNPS-------------------DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK 175
Q P+ +V+ G ++C G P P + W KD P+
Sbjct: 203 QFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPG 261
Query: 176 DERITIR--GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSF--VKRPSN 231
+ ++ G L IT + D G+Y CV + G++ + +L V P+
Sbjct: 262 GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDF-QLRVHAPPTIWGSNETGE 320
Query: 232 LAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEI--RDDHTLKIRKVTAGDMGSY 289
+AV D + CEARG P P + W KD LP S + R L++ + + D G Y
Sbjct: 321 VAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVY 380
Query: 290 TCVAENMVGKAEASATLTVQEPPHFVV---KPRDQVVALGRTVTFQCEATGNPQPAIFWR 346
TC A N VG AE + L V PP +P GR V +C A G+P P + W
Sbjct: 381 TCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWH 440
Query: 347 REGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLE 405
EG P S+ + G L + + + G Y C + AG + + +E
Sbjct: 441 HEGL--------PVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVE 492
Query: 406 VTDVIADRPPP--VIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRI 463
V + PP ++ +G T V L C A+GSPVPTI W ++G
Sbjct: 493 V------QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQ 546
Query: 464 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFG 507
+ L I + +L +G + C A+ +G A A +EV G
Sbjct: 547 VASQGTTLHIDHVELDHSGLFACQATNEAGTA--GAEVEVSVHG 588
Score = 142 bits (359), Expect = 2e-33
Identities = 121/456 (26%), Positives = 190/456 (41%), Gaps = 35/456 (7%)
Query: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
DEG+Y C A N GE+ +L+V ++ + P + V +EC G P P
Sbjct: 668 DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECLAS-GVPPP 724
Query: 162 TISWKKDGSPLDD-KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
+SW K P+ +++ G L I + SDAG Y CV +N+ G E L V
Sbjct: 725 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-LRVN 783
Query: 221 ERPSFVKRPSNLA-VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHT 275
P PS V V+ C A G P PT+ W KD + +
Sbjct: 784 VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV 843
Query: 276 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA 335
L + A D G Y+CVA + VG+ L V PP + + + V +V +C++
Sbjct: 844 LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQS 903
Query: 336 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV---GYYICQTL 392
P P + W ++G R V + D + V R+DV G+Y C+ L
Sbjct: 904 HAMPPPVLSWWKDGRP----------LEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 953
Query: 393 NVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD 452
N AG ++ + + +A P +R+ TV LSC G P P I WRKD
Sbjct: 954 NQAGR--SEKHYNLNVWVAPVFP--LRESHT-LTVREGHPTSLSCECRGVPFPKISWRKD 1008
Query: 453 GVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ---EFG 507
G + + + ++ + +L + A+L G YTC S G ++ +EV +
Sbjct: 1009 GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 1068
Query: 508 VPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 543
P +P PT +++ + E + T++W+
Sbjct: 1069 GPREP--PTQVSVVQDGVATLECNATGKPPPTVTWE 1102
Score = 132 bits (331), Expect = 4e-30
Identities = 153/585 (26%), Positives = 231/585 (39%), Gaps = 72/585 (12%)
Query: 43 GEPATLNCKAEGRPTPTIEWYK-------GGERVETDKDDPRSHRMLLPSGSLFFLRIVH 95
G L C G PTP +EW K GG ++ +D LRI
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ-------------VLRITG 278
Query: 96 GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 155
DEG Y CVA + G+ + + L V + N + + + + V
Sbjct: 279 SHVG--DEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 335
Query: 156 RGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESEV 214
RG P P I+W KDG+ L + + RGG+ L + + SDAG Y C +N VG E +
Sbjct: 336 RGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAE-KA 394
Query: 215 AELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD---GELPKSRY 268
L V P+ RP + +C ARG P PT+ W + E +SR
Sbjct: 395 TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRL 454
Query: 269 EIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV-KPRDQVVAL-G 326
E D L++ G Y+CVA + G+A ++ VQ PP +V + QV + G
Sbjct: 455 E-TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVG 513
Query: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVG 385
+ + C+A+G+P P I W + G +P + + V+ G L I +V+ G
Sbjct: 514 QPLELPCQASGSPVPTIQWLQNG--------RPAEELAGVQVASQGTTLHIDHVELDHSG 565
Query: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ---TVAVDGTFVLSC---VA 439
+ CQ N AG+ A EV + P + + P+ Q +F +C V
Sbjct: 566 LFACQATNEAGT----AGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVH 621
Query: 440 TG---SPVPTIL--WRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 493
G P P ++ W G L + LQI L D G YTC A+ +G
Sbjct: 622 RGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 681
Query: 494 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP----------SKPEVTDVSRNTVTLSWQ 543
E+ ++V P P P + ++ +A P+V+ + SW
Sbjct: 682 ESKREVALKV--LVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWM 739
Query: 544 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPN 588
+ IE + S++ VA NV T GL+ N
Sbjct: 740 -GVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVN 783
Score = 131 bits (330), Expect = 5e-30
Identities = 94/281 (33%), Positives = 129/281 (45%), Gaps = 19/281 (6%)
Query: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
P D + G+ L C A G PTP I W T D P + + G R
Sbjct: 2944 PGDRSLRLGDRLWLRCAARGSPTPRIGW--------TVNDRPVTEGVSEQDGGSTLQRAA 2995
Query: 95 HGRKSRPDEGVYVCVARNYLG--EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152
SR D G YVC A N +G +AVS E +L+ + S ++ VG ++C
Sbjct: 2996 ---VSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF---SYLVEPVGGSIQLDC 3049
Query: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
RG P P I W KDG PL R ++ G L I T + DAG+Y C+ N +G +
Sbjct: 3050 VV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK- 3107
Query: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR-YEIR 271
+V L + P F P ++ V D +C+A G+P PT+ W + L SR
Sbjct: 3108 KVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTL 3167
Query: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
D +L + V GD G+Y CVA N++G A A A L V+ P
Sbjct: 3168 PDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208
Score = 125 bits (315), Expect = 3e-28
Identities = 138/495 (27%), Positives = 197/495 (39%), Gaps = 64/495 (12%)
Query: 50 CKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCV 109
C G P P + W KG ++ + +L GSLF + S D G Y C
Sbjct: 24 CGTHGTPKPQVTWRKG---PSSEPLHGQPGVAVLEEGSLFLASV-----SPADSGDYECQ 75
Query: 110 ARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWK 166
A N +G + S A L V + +R+D R+ ++V G+ +EC G P P I W
Sbjct: 76 ATNEVG-STSRRAKLVVYVPPSIREDGRK--ANVSGMAGQSLTLECD-ANGFPVPEIVWL 131
Query: 167 KD----GSPL------------DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGER 210
KD G PL R+ G L + +G+ +
Sbjct: 132 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTK 191
Query: 211 ESEVAELTVLER---PSFVKRPSNLAVTVDDSA-----------EFKCEARGDPVPTVRW 256
A L E+ P P+ +V +A E +C G P P V W
Sbjct: 192 APWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 251
Query: 257 RKD-DGELPKSRY-EIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPH 313
KD LP + ++++D L+I GD G Y CVA + G+ L V PP
Sbjct: 252 TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 311
Query: 314 FVVKPRDQVVAL--GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
VA+ V CEA G P P I W ++G+ LL P S+
Sbjct: 312 IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA--LL-----PTSTKVVYTRGG 364
Query: 372 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV-AVD 430
L + Q SD G Y C+ N G+ L+V PP + G V AV
Sbjct: 365 RQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY-----VPPTIEGAGGRPYVVKAVA 419
Query: 431 GTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 489
G V L CVA G P PT+ W +G+ V+ + + + VL++ +G Y+C+AS
Sbjct: 420 GRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS 479
Query: 490 TPSGEATWSAYIEVQ 504
+P+GEA +EVQ
Sbjct: 480 SPAGEAVLQYSVEVQ 494
Score = 99.8 bits (247), Expect = 2e-20
Identities = 115/428 (26%), Positives = 163/428 (38%), Gaps = 58/428 (13%)
Query: 157 GHPEPTISWKKDGS--PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 214
G P+P ++W+K S PL + + G L + +D+G Y C TN VG S
Sbjct: 28 GTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS-TSRR 86
Query: 215 AELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD------------ 260
A+L V PS + R +N++ S +C+A G PVP + W KD
Sbjct: 87 AKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGY 146
Query: 261 ------GELPKSRY--EIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP- 311
G++ R E + H +I+ +G G+ + A Q P
Sbjct: 147 GWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPT 206
Query: 312 PHFVVKP----------RDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 360
PH P +V+ L G V QC +G P P + W ++ L
Sbjct: 207 PHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVL------- 259
Query: 361 QSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 419
V + G L IT D G Y C + AG L V PP I
Sbjct: 260 PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV------HAPPTIW 313
Query: 420 QGPVNQTVAV--DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477
VAV D L C A G P P I W KDG L+ T + LQ+ A+
Sbjct: 314 GSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQ 373
Query: 478 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTD-VSRN 536
D G YTC AS G A + ++V + P P ++ + +P + V+R
Sbjct: 374 SSDAGVYTCKASNAVGAAEKATRLDV--YVPPTIEGAGGRPYVVKAVAGRPVALECVARG 431
Query: 537 --TVTLSW 542
+ TLSW
Sbjct: 432 HPSPTLSW 439
Score = 87.8 bits (216), Expect = 8e-17
Identities = 80/295 (27%), Positives = 120/295 (40%), Gaps = 30/295 (10%)
Query: 226 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP---KSRYEIRDDHTLKIRKVT 282
+K ++A+TV A C G P P V WRK P + + ++ +L + V+
Sbjct: 7 IKGLGDVALTVGLEAG-GCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVS 65
Query: 283 AGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA--LGRTVTFQCEATGNPQ 340
D G Y C A N VG A L V PP R V+ G+++T +C+A G P
Sbjct: 66 PADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPV 125
Query: 341 PAIFWRRE--------GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTL 392
P I W ++ G + Q + + L +Q G Q
Sbjct: 126 PEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQ-- 183
Query: 393 NVAGSIITKA-----------YLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV-LSCVAT 440
GS TKA + PP V+ G + + + G V L C +
Sbjct: 184 -AGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTS 242
Query: 441 GSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGE 494
G P P + W KD V ++ E+G VL+I + +GD GRY C+A +P+G+
Sbjct: 243 GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 297
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 208 bits (529), Expect = 4e-53
Identities = 149/478 (31%), Positives = 215/478 (44%), Gaps = 31/478 (6%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
P + PS + E L C+A G P PTI W K G V T +LP G L
Sbjct: 3948 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 4002
Query: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 148
RI H S D G Y+C+A+N G A+ V + D+ G A
Sbjct: 4003 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 4055
Query: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMV 207
+ C+ RG PEP I+W KDG P+ + + TI+ G+L++ DAG Y C N V
Sbjct: 4056 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 4114
Query: 208 GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR 267
G V LT+L P F P + ++ + D +C ARG P P + W +D + +
Sbjct: 4115 GRARRRV-HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 4173
Query: 268 YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA-LG 326
E TL+ V+ D G+Y C AEN VG+ +A + + V+E P + +V +G
Sbjct: 4174 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVG 4233
Query: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 386
++ C G+P P I W ++G P + S Q G LTI +R D G
Sbjct: 4234 GSIQLDCVVRGDPVPDIHWIKDGL--------PLRGSHLRHQLQNGSLTIHRTERDDAGR 4285
Query: 387 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 446
Y C N G + K + ++ + PV + P + TV L C ATG P PT
Sbjct: 4286 YQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT 4339
Query: 447 ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
I W + G + R++ L +G L + + GD G Y C+A G AT A++ V+
Sbjct: 4340 IEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 4396
Score = 194 bits (493), Expect = 6e-49
Identities = 154/500 (30%), Positives = 220/500 (44%), Gaps = 40/500 (8%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
P I P + VS + A L C+A+G P P + W K +RV D PR +LP GSL
Sbjct: 3673 PTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRK--DRVPLDPRSPRFE--ILPEGSL 3728
Query: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-FRQNPSDVMVAVGEP 147
++ D G Y+C+A N G S ++ +L +PS++ + P
Sbjct: 3729 RIQPVL-----AQDAGHYLCLASNSAG---SDRQGRDLRVLEPPAIAPSPSNLTLTAHTP 3780
Query: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIR---GGKLMITYTRKSDAGKYVCVGT 204
A++ C+ G P+P + W KDG LD + ++ R L++T D+ ++ CV +
Sbjct: 3781 ALLPCEAS-GSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVS 3839
Query: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
N VGE + ++TV P+ ++ VT+ C + G P PTV W K +L
Sbjct: 3840 NEVGEAH-RLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLG 3898
Query: 265 K--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV 322
S Y + L+I + G YTC A N G A LTVQ P VVKP V
Sbjct: 3899 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASP--VVKPLPSV 3956
Query: 323 V--ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
V V CEA+G P+P I W++EG + V G L I +
Sbjct: 3957 VRAVAEEEVLLPCEASGIPRPTITWQKEGLN--------VATGVSTQVLPGGQLRIAHAS 4008
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 440
D G Y+C N AGS + K L V + PPVI G + + L C A
Sbjct: 4009 PEDAGNYLCIAKNSAGSAMGKTRLVV------QVPPVIENGLPDLSTTEGSHAFLPCKAR 4062
Query: 441 GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 500
GSP P I W KDG VS + + +G L ++ + D G YTC A G A +
Sbjct: 4063 GSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVH 4122
Query: 501 IEVQEFGVPVQPPRPTDPNL 520
+ + +PV P D +L
Sbjct: 4123 LTI--LVLPVFTTLPGDRSL 4140
Score = 192 bits (489), Expect = 2e-48
Identities = 158/510 (30%), Positives = 222/510 (43%), Gaps = 49/510 (9%)
Query: 28 PPRI---VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
PP I + L+ GE T+ C G P + W K G + P S R LL
Sbjct: 3310 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 3362
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVM 141
GS LRI + D G++ CVA + G A N +L+V + L QN DV+
Sbjct: 3363 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 3417
Query: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 201
V G + C+ RG P P +SW KDG PL + +G L + D+G Y C
Sbjct: 3418 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 3473
Query: 202 VGTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
V + GE +LTV+E P +P+ L++T E C+A+G P P + W KD
Sbjct: 3474 VAVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 3532
Query: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
L + R L++R D G YTC+AE+ G E S + VQ PP+ +V PR
Sbjct: 3533 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPN-IVGPR 3586
Query: 320 DQVVALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 376
+G + +C P P I W R+G ++ RF L +
Sbjct: 3587 GPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF-------LQL 3639
Query: 377 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 436
+ +D G Y C N AGS +E+ V P IR GP V+V+ T +L
Sbjct: 3640 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALLP 3693
Query: 437 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 496
C A G P P + WRKD V + + R + L G L+I+ D G Y C+AS +G
Sbjct: 3694 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 3753
Query: 497 WSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 526
+ V E P P P++ L P+
Sbjct: 3754 QGRDLRVLE--PPAIAPSPSNLTLTAHTPA 3781
Score = 186 bits (472), Expect = 2e-46
Identities = 156/542 (28%), Positives = 231/542 (42%), Gaps = 56/542 (10%)
Query: 28 PPRIVE--HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP I + P++L ++ G P L C A+G P P I W+K G+ + +++ R+ R+L
Sbjct: 3493 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 3552
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 145
D G+Y C+A + G S V + P VG
Sbjct: 3553 ----------------DAGLYTCLAESPAGAI---EKSFRVRVQAPPNIVGPRGPRFVVG 3593
Query: 146 ---EPAVMECQPPRGHPEPTISWKKDGSPL-DDKDERITIRGGKLMITYTRKSDAGKYVC 201
V+EC P P I+W +DG L +D + RG L + +D+G Y C
Sbjct: 3594 LAPGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSC 3652
Query: 202 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
N G S + + P+ P + V+V+ +A C+A G P P V WRKD
Sbjct: 3653 TARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRV 3711
Query: 262 EL-PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
L P+S R+EI + +L+I+ V A D G Y C+A N G L V EPP P
Sbjct: 3712 PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 3771
Query: 320 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 379
+ + CEA+G+P+P + W ++G Q L F Q + + + L +T
Sbjct: 3772 NLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLLTAP 3826
Query: 380 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 439
D + C N G + Y V PP I + TV + VL+C +
Sbjct: 3827 GPQDSAQFECVVSNEVGE-AHRLYQVTVHV-----PPTIADDQTDFTVTMMAPVVLTCHS 3880
Query: 440 TGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 499
TG P PT+ W K G + + S + +G L+I A GRYTC A +G A
Sbjct: 3881 TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHV 3940
Query: 500 YIEVQEFGVPVQPPRPT-------DPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 552
++ VQ PV P P+ + L+P E + + R T+T WQ + AT
Sbjct: 3941 FLTVQ--ASPVVKPLPSVVRAVAEEEVLLPC-----EASGIPRPTIT--WQKEGLNVATG 3991
Query: 553 TS 554
S
Sbjct: 3992 VS 3993
Score = 184 bits (466), Expect = 8e-46
Identities = 168/527 (31%), Positives = 234/527 (44%), Gaps = 71/527 (13%)
Query: 47 TLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVY 106
TL C++ P PTI WYK G+ V P S +L G L L+I + S D G Y
Sbjct: 2658 TLECESWAVPPPTIRWYKDGQPVT-----PSSRLQVLGEGRL--LQIQPTQVS--DSGRY 2708
Query: 107 VCVARNYLGE-----------------AVSHNASLEVAILRDDFRQNPSDVMVAV-GEPA 148
+CVA N GE +A+ E+ ++ R ++ V PA
Sbjct: 2709 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 2768
Query: 149 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMV 207
+ C P P ++W ++ PL DE ++GG+ L I R +AG+Y C +N V
Sbjct: 2769 YLYCDT-NAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEV 2827
Query: 208 GERESEVAELTVLERPSFVKRPSNLA--VTVDDSA--EFKCEARGDPVPTVRWRKDDGEL 263
GE EL VL P + L VTV+ S+ +C A G+PVPT+ W ++
Sbjct: 2828 GEDWLHY-ELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPF 2886
Query: 264 -PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 321
P R ++ +D L++ D SY CVAEN G AE TL VQ PP +Q
Sbjct: 2887 SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQ 2946
Query: 322 VVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
V A L +V+ C+ +P P + W ++ SQ L + F + T L + +
Sbjct: 2947 VTAILNSSVSLPCDVHAHPNPEVTWYKD-SQALSLGEEV------FLLPGTHTLQLGRAR 2999
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ----TVAVDGTFVLS 436
SD G Y C+ LN AG L V PP RQ P V V VLS
Sbjct: 3000 LSDSGMYTCEALNAAGRDQKLVQLSVL------VPPAFRQAPRGPQDAVLVRVGDKAVLS 3053
Query: 437 CVATGSPVPTILWRKDG-VLVSTQDSRIKQLENGV-LQIRYAKLGDTGRYTCIASTPSGE 494
C P PT+ W KDG LV Q R + L G L+I+ A++ D G Y+C S +GE
Sbjct: 3054 CETDALPEPTVTWYKDGQPLVLAQ--RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 3111
Query: 495 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 541
A V+ F + VQ P PT N P V+ V+ + + L+
Sbjct: 3112 A-------VRTFTLTVQVP-PTFEN-----PKTETVSQVAGSPLVLT 3145
Score = 182 bits (462), Expect = 2e-45
Identities = 145/478 (30%), Positives = 203/478 (42%), Gaps = 34/478 (7%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP I P + V + TL C A G P P + W+KG + V S + S
Sbjct: 1885 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 1937
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
LRI + S D G Y CVA N G + L V + V V P
Sbjct: 1938 GRVLRIEQAQLS--DAGSYRCVASNVAG-STELRYGLRVNVPPRITLPPSLPGPVLVNTP 1994
Query: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDE---RITIRGGKLMITYTRKSDAGKYVCVGT 204
+ C G P PT+ W KDG+P+ ++ G L + R SD+G+Y CV
Sbjct: 1995 VRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 2053
Query: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL- 263
+ VGE +V L V PS + N++V ++S +C++ P P + W KD L
Sbjct: 2054 SAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 2112
Query: 264 PKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV 322
P+ + D L ++ + D G YTC A N G +E L V P F ++ +
Sbjct: 2113 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL 2172
Query: 323 -VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQ 380
V G + CE G P P I WR++G P + + VS G L + Q
Sbjct: 2173 TVREGHPTSLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQAQ 2226
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI---RQGPVNQTVAVDGTFVLSC 437
+ G Y C+ NV G+ LEV PP I R+ P +V DG L C
Sbjct: 2227 LAQEGTYTCECSNVVGNSSQDLQLEV------HVPPQIAGPREPPTQVSVVQDGVATLEC 2280
Query: 438 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 495
ATG P PT+ W +DG V + Q + L + A+ TGRY+C+A +G A
Sbjct: 2281 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 2338
Score = 178 bits (451), Expect = 4e-44
Identities = 142/515 (27%), Positives = 215/515 (41%), Gaps = 41/515 (7%)
Query: 1 MIAEPAHFYLFGLICLCS---GSRLRQEDF----PPRIVEHPSDLIVSKGEPATLNCKAE 53
++A+ A YL CL S GS + D PP I PS+L ++ PA L C+A
Sbjct: 3733 VLAQDAGHYL----CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS 3788
Query: 54 GRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNY 113
G P P + W+K G++++ + LLPS +L D + CV N
Sbjct: 3789 GSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNALLLTA-----PGPQDSAQFECVVSNE 3841
Query: 114 LGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD 173
+GEA H + + +D V + P V+ C G P PT+SW K G+ L
Sbjct: 3842 VGEA--HRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHST-GIPAPTVSWSKAGAQLG 3898
Query: 174 DKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNL 232
+ + G L I AG+Y C N G V LTV P PS +
Sbjct: 3899 ARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVF-LTVQASPVVKPLPSVV 3957
Query: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTC 291
++ CEA G P PT+ W+K+ + ++ L+I + D G+Y C
Sbjct: 3958 RAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC 4017
Query: 292 VAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 351
+A+N G A L VQ PP D G C+A G+P+P I W ++G
Sbjct: 4018 IAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDG-- 4075
Query: 352 NLLFSYQPPQSSS-RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVI 410
QP + +F++ +G+L + N++ D G Y C N G + +L + +
Sbjct: 4076 ------QPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVL- 4128
Query: 411 ADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGV 470
PV P ++++ + L C A GSP P I W + V+ S +Q
Sbjct: 4129 -----PVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS--EQDGGST 4181
Query: 471 LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 505
LQ D+G Y C A G +++ V+E
Sbjct: 4182 LQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE 4216
Score = 177 bits (449), Expect = 7e-44
Identities = 146/489 (29%), Positives = 212/489 (43%), Gaps = 44/489 (8%)
Query: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Q PP I+ ++ V E L C++ P P + W+K G +E PR L
Sbjct: 2066 QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 2120
Query: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 143
+L + R D G Y C A N G + H +L V + + + V
Sbjct: 2121 ADKALLQV----DRADVWDAGHYTCEALNQAGHSEKH-YNLNVWVAPVFPLRESHTLTVR 2175
Query: 144 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD---ERITIRGGKLMITYTRKSDAGKYV 200
G P + C+ RG P P ISW+KDG PL + + ++ G L + + + G Y
Sbjct: 2176 EGHPTSLSCE-CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 2234
Query: 201 CVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
C +N+VG S+ +L V P + P+ ++V D A +C A G P PTV W
Sbjct: 2235 CECSNVVG-NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE 2293
Query: 258 KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHF 314
+ DG+ + ++ +L + + A G Y+CVAEN+ G+AE L+V PP
Sbjct: 2294 R-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 2352
Query: 315 V--VKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
+ + P + AL +T CEA G P PAI W F + P S +
Sbjct: 2353 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW---------FRGEEPVSPGEDTYLLA 2403
Query: 372 GD--LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 429
G L +T Q D G Y C N AG +EV PP I + + + V
Sbjct: 2404 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEVIKV 2457
Query: 430 -DG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 487
DG T L C TG P P + W KDG ++ D+ + +LQ+ A L G Y+CI
Sbjct: 2458 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 2517
Query: 488 ASTPSGEAT 496
A+ GE T
Sbjct: 2518 AANAVGEKT 2526
Score = 177 bits (449), Expect = 7e-44
Identities = 158/512 (30%), Positives = 225/512 (43%), Gaps = 58/512 (11%)
Query: 35 PSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 93
P D ++V G+ A L+C+ + P PT+ WYK G+ + L G L I
Sbjct: 3038 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL-----AQRTQALRGGQR--LEI 3090
Query: 94 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 153
+ S D+G+Y C N GEAV +L V + V G P V+ C
Sbjct: 3091 QEAQVS--DKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 3147
Query: 154 PPRGHPEPTISWKKDGSPLDDKD-ERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
G P PT++W KD P++ + RGG+L ++ + + AG Y CV N E
Sbjct: 3148 -VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 3206
Query: 213 EVAELTVLERPSFVKRPSNLA----VTVDDSAEFKCEARGDPVPTVRWRKDDGEL----- 263
+ + VL P R S +A V CEA G P P V W KD L
Sbjct: 3207 DFV-VAVLVAPRI--RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 3263
Query: 264 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV 323
P R+ + D +L ++ + A D G+YTCVA N G+ T+ V PP + + D
Sbjct: 3264 PHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPP-TIKQGADGSG 3321
Query: 324 AL----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITN 378
L G VT C G+P + W ++G P S R + +G L I+
Sbjct: 3322 TLVSRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISK 3373
Query: 379 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV---NQTVAVDGTFV- 434
VQ +D G + C + AG L+V + PPV+ PV N V V G+ V
Sbjct: 3374 VQLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLE--PVEFQNDVVVVRGSLVE 3425
Query: 435 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSG 493
L C A G P+P + W KDG + +Q LE G LQ+ GD+G Y+C+A + +G
Sbjct: 3426 LPCEARGVPLPLVSWMKDGEPLLSQ-----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAG 3480
Query: 494 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 525
EA + V E +PT+ +L P AP
Sbjct: 3481 EARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 3512
Score = 173 bits (438), Expect = 1e-42
Identities = 152/556 (27%), Positives = 231/556 (41%), Gaps = 71/556 (12%)
Query: 28 PPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
PP+I E P+ + V + ATL C A G+P PT+ W + G+ V + L
Sbjct: 2255 PPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELG-----LQLQN 2309
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD----V 140
G + R G Y CVA N G A E+++L D +
Sbjct: 2310 QGQSLHVE----RAQAAHTGRYSCVAENLAGRA---ERKFELSVLVPPELIGDLDPLTNI 2362
Query: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGG-KLMITYTRKSDAGKY 199
A+ P + C+ G P P I W + P+ ++ + GG L +T T++ D+G Y
Sbjct: 2363 TAALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLY 2421
Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD--SAEFKCEARGDPVPTVRWR 257
C+ +N GE + + VL PS + V D +A C G P P + W
Sbjct: 2422 SCLASNEAGEARRNFS-VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWF 2480
Query: 258 KDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
KD L + + + D L++ + G Y+C+A N VG+ L+V P +
Sbjct: 2481 KDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTIL 2540
Query: 316 VKPRDQV-----VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 370
D V + ++ CEA P P I W ++G+ P ++S +
Sbjct: 2541 GGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA--------PFEASRNIQLLP 2592
Query: 371 -TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT--- 426
T L I N Q+ D G Y C N G + ++EV PP + + P+ +
Sbjct: 2593 GTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI-----PPSISKDDPLGEVGVK 2647
Query: 427 ---VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTG 482
V+ T L C + P PTI W KDG V T SR++ L G +LQI+ ++ D+G
Sbjct: 2648 EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLGEGRLLQIQPTQVSDSG 2706
Query: 483 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 542
RY C+A+ +GE + Q+F V +Q P P +V D S LS
Sbjct: 2707 RYLCVATNVAGE-------DDQDFNVLIQVP-----------PMFQKVGDFSAAFEILSR 2748
Query: 543 QPNLNSGATPTSYIIE 558
+ G T I+E
Sbjct: 2749 EEEARGGVTEYREIVE 2764
Score = 171 bits (434), Expect = 4e-42
Identities = 126/385 (32%), Positives = 175/385 (45%), Gaps = 32/385 (8%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP I DL ++G A L CKA G P P I W K G+ V + PSG
Sbjct: 4037 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS----GAEGKFTIQPSGE 4092
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 147
L ++ + G+ D G Y C A N +G A L + +L F P D + +G+
Sbjct: 4093 LL-VKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 4145
Query: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
+ C RG P P I W + P+ + G L + D+G YVC N V
Sbjct: 4146 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQD-GGSTLQRAAVSREDSGTYVCWAENRV 4203
Query: 208 GERES----EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 263
G ++ V E VL+ +F S L V S + C RGDPVP + W KD L
Sbjct: 4204 GRTQAVSFVHVKEAPVLQGEAF----SYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 4259
Query: 264 PKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 321
S R+++++ +L I + D G Y C+AEN +G A+ L +Q P F V+P+D
Sbjct: 4260 RGSHLRHQLQNG-SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM 4318
Query: 322 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 381
V G V +C+ATG P P I W + G QP ++S R G L + NV+
Sbjct: 4319 TVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLENVET 4370
Query: 382 SDVGYYICQTLNVAGSIITKAYLEV 406
D G Y C N+ GS +A+L V
Sbjct: 4371 GDAGTYDCVAHNLLGSATARAFLVV 4395
Score = 164 bits (414), Expect = 8e-40
Identities = 142/497 (28%), Positives = 204/497 (41%), Gaps = 53/497 (10%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
P++ H S S+G ++C A G PTP I W + + ++ +D R H + G+L
Sbjct: 608 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ---EDSRIH--VDAQGTL 662
Query: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD------VMV 142
I+ G + D G Y C A N +G E L + PS V+V
Sbjct: 663 ----IIQG-VAPEDAGNYSCQATNEVG------TDQETVTLY--YTDPPSVSAVNAVVLV 709
Query: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
AVGE AV+ C+ G P P + W + G + E + GKL I ++ DAG Y C
Sbjct: 710 AVGEEAVLVCEAS-GVPPPRVIWYRGGLEMILAPEGSS--SGKLRIPAAQERDAGTYTCR 766
Query: 203 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 262
N +G+ +E+ +L V P + P ++ V + SA C A G P PTV WR+ DG+
Sbjct: 767 AVNELGDASAEI-QLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 825
Query: 263 L--------PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QEPP 312
SR D L V D Y C A N+ GK +A A L V PP
Sbjct: 826 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 885
Query: 313 HFVVKPRDQVVALGRTVTFQCEA-TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
V G+ V+ C G P P W ++G +P SR S+
Sbjct: 886 QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG--------RPLPPGSRHSIRAD 937
Query: 372 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 431
G L + + G Y C N AGS +E+ + R P N+ V
Sbjct: 938 GSLHLDRALQEHAGRYSCVATNTAGS--QHRDVELVVQVPPRIHPTATHHITNEGVPAS- 994
Query: 432 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 491
L CVA+G P PTI W K+ ++++ + G L I D G Y C A+
Sbjct: 995 ---LPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNT 1051
Query: 492 SGEATWSAYIEVQEFGV 508
G ++ + V +
Sbjct: 1052 VGFSSQEMRLSVNRLAL 1068
Score = 162 bits (410), Expect = 2e-39
Identities = 150/519 (28%), Positives = 216/519 (41%), Gaps = 69/519 (13%)
Query: 28 PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP I + ++ G+ A L C G P P + W+K G + +H + P
Sbjct: 2443 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 2497
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH---NASLEVAILRDDFRQNPSDVMV 142
G L L+++ S G Y C+A N +GE H + L IL +V V
Sbjct: 2498 GVL--LQVLQANLS--SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 2553
Query: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVC 201
V P + C+ P P I+W KDG+P + + G L I +K DAG+Y C
Sbjct: 2554 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 2612
Query: 202 VGTNMVGERESEVAELTVLERPSFVKRP-------SNLAVTVDDSAEFKCEARGDPVPTV 254
V TN +GE + VL PS K + V+ + +CE+ P PT+
Sbjct: 2613 VVTNELGEAVKNY-HVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTI 2671
Query: 255 RWRKDDGEL-PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
RW KD + P SR ++ + L+I+ D G Y CVA N+ G+ + + +Q PP
Sbjct: 2672 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 2731
Query: 313 HFV----------VKPRDQVVALGRT----------VTFQCEATGNPQPAIFWRREGSQN 352
F + R++ G T C+ P P + W RE
Sbjct: 2732 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED--- 2788
Query: 353 LLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 411
QP + SV Q G L I V+ + G Y C+ N G L V
Sbjct: 2789 -----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 2840
Query: 412 DRPPPVIRQGPVNQ-----TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 466
PPVI G + TV T L C A G+PVPTI W ++G L + R++ L
Sbjct: 2841 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-LPFSPSPRLQVL 2895
Query: 467 ENG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 504
E+G VLQ+ A++ D Y C+A +G A + VQ
Sbjct: 2896 EDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 2934
Score = 162 bits (409), Expect = 3e-39
Identities = 129/472 (27%), Positives = 192/472 (40%), Gaps = 45/472 (9%)
Query: 40 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLPSGSLFFLRIVHG 96
+ + PA L C P P + WY+ +D P S +L G + + +V
Sbjct: 2762 IVENNPAYLYCDTNAIPPPDLTWYR--------EDQPLSAGDEVSVLQGGRVLQIPLVRA 2813
Query: 97 RKSRPDEGVYVCVARNYLGEAVSHNASLEVA--ILRDDFRQNPSDVMVAVGEPAVMECQP 154
+ G Y C A N +GE H L + ++ D + +V V ++C P
Sbjct: 2814 ENA----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-P 2868
Query: 155 PRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESE 213
G+P PTISW ++G P + G+ L ++ +DA Y+CV N G E +
Sbjct: 2869 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE-K 2927
Query: 214 VAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR--YEI 270
+ L V P + ++ S C+ P P V W KD L + +
Sbjct: 2928 LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL 2987
Query: 271 RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ----VVALG 326
HTL++ + D G YTC A N G+ + L+V PP F PR +V +G
Sbjct: 2988 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 3047
Query: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVG 385
CE P+P + W ++G QP + R + G L I Q SD G
Sbjct: 3048 DKAVLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVSDKG 3099
Query: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCVATGSP 443
Y C+ NVAG + L V + PP + P +TV+ VL+C +G P
Sbjct: 3100 LYSCKVSNVAGEAVRTFTLTV------QVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVP 3152
Query: 444 VPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 495
PT+ W KD + V + G LQ+ + G YTC+A EA
Sbjct: 3153 APTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 3204
Score = 161 bits (407), Expect = 5e-39
Identities = 159/548 (29%), Positives = 219/548 (39%), Gaps = 69/548 (12%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP++ P L V GE LNC AEG P P + W K G ++ P GS
Sbjct: 1119 PPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG----------PQGS 1168
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDF--RQNPSDVMVAV- 144
+ F I D G Y C A N G +E+ +L S ++ V
Sbjct: 1169 VHFAAI-----RTSDAGRYRCEASNSAGVDA---WEVELRVLEPPHWGADETSGLLERVA 1220
Query: 145 GEPAVMECQPPRGHPEPTISWKKDGS--PLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
GE A + C P RG P+P ++W+K S PL + + G L + +D+G Y C
Sbjct: 1221 GENASLPC-PARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQ 1279
Query: 203 GTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260
TN VG S A+L V PS + R +N++ S +C+A G PVP + W KD
Sbjct: 1280 ATNEVGS-TSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA 1338
Query: 261 ------------------GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA 302
G++ R + + +L ++ GD G Y+C AEN G A+
Sbjct: 1339 QLVGVPLGWAGYGWDLGWGQVGGHRL-LDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQR 1397
Query: 303 SATLTVQEPPHFVVKPRDQVV--ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 360
L V PP + Q V G V QC +G P P + W ++ L
Sbjct: 1398 DFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVL------- 1450
Query: 361 QSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 419
V + G L IT D G Y C + AG L V PP I
Sbjct: 1451 PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV------HAPPTIW 1504
Query: 420 QGPVNQTVAV--DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477
VAV D L C A G P P I W KDG L+ T + LQ+ A+
Sbjct: 1505 GSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQ 1564
Query: 478 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTD-VSRN 536
D G YTC AS G A + ++V + P P ++ + +P + V+R
Sbjct: 1565 SSDAGVYTCKASNAVGAAEKATRLDV--YVPPTIEGAGGRPYVVKAVAGRPVALECVARG 1622
Query: 537 --TVTLSW 542
+ TLSW
Sbjct: 1623 HPSPTLSW 1630
Score = 160 bits (405), Expect = 9e-39
Identities = 144/505 (28%), Positives = 204/505 (40%), Gaps = 48/505 (9%)
Query: 28 PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERV-----------ETDKD 74
PP I E VS G+ TL C A G P P I W K + V +
Sbjct: 1298 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 1357
Query: 75 DPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFR 134
HR+L SL F RI G D G+Y C A N G A L +
Sbjct: 1358 QVGGHRLLDEGQSLHFPRIQEG-----DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 1412
Query: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIR--GGKLMITYTR 192
+V+ G ++C G P P + W KD P+ + ++ G L IT +
Sbjct: 1413 GAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSH 1471
Query: 193 KSDAGKYVCVGTNMVGERESEVAELTVLERPSF--VKRPSNLAVTVDDSAEFKCEARGDP 250
D G+Y CV + G++ + +L V P+ +AV D + CEARG P
Sbjct: 1472 VGDEGRYQCVAFSPAGQQARDF-QLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP 1530
Query: 251 VPTVRWRKDDGELPKSRYEI--RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
P + W KD LP S + R L++ + + D G YTC A N VG AE + L V
Sbjct: 1531 TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 1590
Query: 309 QEPPHFVV---KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 365
PP +P GR V +C A G+P P + W EG P S+
Sbjct: 1591 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGL--------PVAESNE 1642
Query: 366 FSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP--VIRQGP 422
+ G L + + + G Y C + AG + + +EV + PP ++ +G
Sbjct: 1643 SRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV------QVPPQLLVAEGL 1696
Query: 423 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTG 482
T V L C A+GSPVPTI W ++G + L I + +L +G
Sbjct: 1697 GQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSG 1756
Query: 483 RYTCIASTPSGEATWSAYIEVQEFG 507
+ C A+ +G A A +EV G
Sbjct: 1757 LFACQATNEAGTA--GAEVEVSVHG 1779
Score = 158 bits (400), Expect = 4e-38
Identities = 159/570 (27%), Positives = 220/570 (38%), Gaps = 52/570 (9%)
Query: 26 DFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
D PP++V P+ + VS GE A L+C+ G + W R R+L S
Sbjct: 515 DPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------------RDWRVLPAS 560
Query: 86 ----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILR-DDFRQNPSDV 140
L L + D G Y CVA N G AS+ + + + S
Sbjct: 561 TGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLLVREAPQVSIHTSSQ 617
Query: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKY 199
+ G + C G+P P ISW ++ L + D RI + G L+I DAG Y
Sbjct: 618 HFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGTLIIQGVAPEDAGNY 675
Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
C TN VG + E L + PS + + V V + A CEA G P P V W +
Sbjct: 676 SCQATNEVGT-DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRG 734
Query: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 319
E+ + E L+I D G+YTC A N +G A A L V P PR
Sbjct: 735 GLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPR 793
Query: 320 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 379
D V LGR+ C ATG P P + WRR Q L + SR +G L +V
Sbjct: 794 DVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSRSRQPDSGVLFFESV 852
Query: 380 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 439
D Y+C+ NV G + +A L VT PP + P + + + V
Sbjct: 853 APEDQAPYVCEARNVFGKVQAEARLIVT---GHAPPQIASSAPTVRVLEGQPVSLPCIVL 909
Query: 440 TGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 499
G P+P W KDG + SR +G L + A GRY+C+A+ +G
Sbjct: 910 AGRPLPERHWLKDGRPL-PPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDV 968
Query: 500 YIEVQEFGVPVQPPR--------------PTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 545
+ VQ PPR P + S P +T S P+
Sbjct: 969 ELVVQ------VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPH 1022
Query: 546 LNSGATPTSYIIEAFSHASGSSWQTVAENV 575
N T I + + +G+ T V
Sbjct: 1023 YNVSKEGTLLIAQPSAQDAGAYVCTATNTV 1052
Score = 155 bits (393), Expect = 2e-37
Identities = 142/534 (26%), Positives = 196/534 (36%), Gaps = 83/534 (15%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLP-SG 86
P++ E P D+ V G A L C+A GRP PT+ W +G G+ + R R P SG
Sbjct: 786 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 845
Query: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
LFF + + D+ YVC ARN G+ + + + V V G+
Sbjct: 846 VLFFESV-----APEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQ 900
Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
P + C G P P W KDG PL G L + + AG+Y CV TN
Sbjct: 901 PVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNT 960
Query: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-------------- 252
G + +V EL V P ++ A C A G P P
Sbjct: 961 AGSQHRDV-ELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 1019
Query: 253 -------------------------------TVRWRKDDGELPKSR----------YEIR 271
TV + + L +R Y +
Sbjct: 1020 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLL 1079
Query: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTF 331
+L++ +V GD G Y C A N G A L VQ PP PR V +G +
Sbjct: 1080 PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDL 1139
Query: 332 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 391
C A GNP+P + W ++G ++ + PQ S F+ +T SD G Y C+
Sbjct: 1140 NCVAEGNPEPQLSWSKDG---VVLQGRGPQGSVHFAAIRT----------SDAGRYRCEA 1186
Query: 392 LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILWR 450
N AG + L V + PP V G L C A G+P P + WR
Sbjct: 1187 SNSAGVDAWEVELRVLE-----PPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWR 1241
Query: 451 KDGVLVSTQ-DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 503
K + LE G L + D+G Y C A+ G + A + V
Sbjct: 1242 KGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295
Score = 155 bits (393), Expect = 2e-37
Identities = 148/534 (27%), Positives = 216/534 (40%), Gaps = 43/534 (8%)
Query: 28 PPRI--VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 85
PP I ++ V + L C+A G PTP I W+K G + P S +++
Sbjct: 1500 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL------PTSTKVVYTR 1553
Query: 86 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVMVAV 144
G ++ GR D GVY C A N +G A + + V + P V
Sbjct: 1554 GGR---QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 1610
Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVG 203
G P +EC RGHP PT+SW +G P+ + +E R+ G L + ++ +G Y CV
Sbjct: 1611 GRPVALECVA-RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 1669
Query: 204 TNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD-- 260
++ GE + + E+ V + + + V E C+A G PVPT++W ++
Sbjct: 1670 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 1729
Query: 261 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QEPPHFVVKP 318
E TL I V G + C A N G A A ++V + P + P
Sbjct: 1730 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVP 1789
Query: 319 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS------SSRFSVSQTG 372
Q G A +P W L+ + P S + S
Sbjct: 1790 IGQY-HWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPP 1848
Query: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 432
L I V D G Y C N+AG + L+V PP I GPVN+ V + +
Sbjct: 1849 PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL------VPPNIEPGPVNKAVLENAS 1902
Query: 433 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 492
L C+A+G P P + W K VS+ ++ VL+I A+L D G Y C+AS +
Sbjct: 1903 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 1962
Query: 493 GEATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 545
G +G+ V PPR T P PS P V R T + P+
Sbjct: 1963 GSTE-------LRYGLRVNVPPRITLP---PSLPGPVLVNTPVRLTCNATGAPS 2006
Score = 153 bits (387), Expect = 1e-36
Identities = 148/519 (28%), Positives = 212/519 (40%), Gaps = 71/519 (13%)
Query: 32 VEHPSDLIVSKG---------EPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
V+ P L+V++G +P L C+A G P PTI+W + G E + +
Sbjct: 1684 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE-----LAGVQV 1738
Query: 83 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
G+ + V S G++ C A N G A A +EV++ + P + V
Sbjct: 1739 ASQGTTLHIDHVELDHS----GLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLEV 1788
Query: 143 AVGE-----------PAVMECQPP--RG---HPEPTI--SWKKDGSPLDDKDERITIRGG 184
+G+ PA C PP RG HP+P + W GS L + I +
Sbjct: 1789 PIGQYHWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 1845
Query: 185 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 241
L I D G Y C TN+ GE + EVA L VL P+ P N AV + S
Sbjct: 1846 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVT 1904
Query: 242 FKCEARGDPVPTVRWRKDDGELPKSRY----EIRDDHTLKIRKVTAGDMGSYTCVAENMV 297
+C A G P P V W K G P S + D L+I + D GSY CVA N+
Sbjct: 1905 LECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 1962
Query: 298 GKAEASATLTVQEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 356
G E L V PP + P V + V C ATG P P + W ++G+
Sbjct: 1963 GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP----- 2017
Query: 357 YQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 415
P + V G LT+ + + SD G Y C ++ G L+V P
Sbjct: 2018 -VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------HMP 2070
Query: 416 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 475
P I +N +V + + L C + P P + W KDG + + + +LQ+
Sbjct: 2071 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDR 2130
Query: 476 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 514
A + D G YTC A +G + + + + PV P R
Sbjct: 2131 ADVWDAGHYTCEALNQAGHS--EKHYNLNVWVAPVFPLR 2167
Score = 153 bits (386), Expect = 1e-36
Identities = 147/490 (30%), Positives = 206/490 (42%), Gaps = 53/490 (10%)
Query: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
GE A+L C A G P P + W KG ++ + +L GSLF + S D
Sbjct: 1221 GENASLPCPARGTPKPQVTWRKGPS---SEPLHGQPGVAVLEEGSLFLASV-----SPAD 1272
Query: 103 EGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 159
G Y C A N +G + S A L V + +R+D R+ ++V G+ +EC G P
Sbjct: 1273 SGDYECQATNEVG-STSRRAKLVVYVPPSIREDGRK--ANVSGMAGQSLTLECDA-NGFP 1328
Query: 160 EPTISWKKD----GSPL------------DDKDERITIRGGKLMITYTRKSDAGKYVCVG 203
P I W KD G PL R+ G L ++ D+G Y C
Sbjct: 1329 VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA 1388
Query: 204 TNMVGERESEVAELTVLERPSFVKRPSNLAVT--VDDSAEFKCEARGDPVPTVRWRKD-D 260
N G + + L VL PS + + V E +C G P P V W KD
Sbjct: 1389 ENQAGTAQRDF-HLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQ 1447
Query: 261 GELPKSRY-EIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP 318
LP + ++++D L+I GD G Y CVA + G+ L V PP
Sbjct: 1448 PVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSN 1507
Query: 319 RDQVVAL--GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 376
VA+ V CEA G P P I W ++G+ LL P S+ L +
Sbjct: 1508 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA--LL-----PTSTKVVYTRGGRQLQL 1560
Query: 377 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV-AVDGTFV- 434
Q SD G Y C+ N G+ L+V PP + G V AV G V
Sbjct: 1561 GRAQSSDAGVYTCKASNAVGAAEKATRLDVYV-----PPTIEGAGGRPYVVKAVAGRPVA 1615
Query: 435 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 494
L CVA G P PT+ W +G+ V+ + + + VL++ +G Y+C+AS+P+GE
Sbjct: 1616 LECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGE 1675
Query: 495 ATWSAYIEVQ 504
A +EVQ
Sbjct: 1676 AVLQYSVEVQ 1685
Score = 142 bits (359), Expect = 2e-33
Identities = 121/456 (26%), Positives = 190/456 (41%), Gaps = 35/456 (7%)
Query: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 161
DEG+Y C A N GE+ +L+V ++ + P + V +EC G P P
Sbjct: 1859 DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECLAS-GVPPP 1915
Query: 162 TISWKKDGSPLDD-KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 220
+SW K P+ +++ G L I + SDAG Y CV +N+ G E L V
Sbjct: 1916 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-LRVN 1974
Query: 221 ERPSFVKRPSNLA-VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHT 275
P PS V V+ C A G P PT+ W KD + +
Sbjct: 1975 VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV 2034
Query: 276 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA 335
L + A D G Y+CVA + VG+ L V PP + + + V +V +C++
Sbjct: 2035 LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQS 2094
Query: 336 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV---GYYICQTL 392
P P + W ++G R V + D + V R+DV G+Y C+ L
Sbjct: 2095 HAMPPPVLSWWKDGRP----------LEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 2144
Query: 393 NVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD 452
N AG ++ + + +A P +R+ TV LSC G P P I WRKD
Sbjct: 2145 NQAGH--SEKHYNLNVWVAPVFP--LRESHT-LTVREGHPTSLSCECRGVPFPKISWRKD 2199
Query: 453 GVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ---EFG 507
G + + + ++ + +L + A+L G YTC S G ++ +EV +
Sbjct: 2200 GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 2259
Query: 508 VPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 543
P +P PT +++ + E + T++W+
Sbjct: 2260 GPREP--PTQVSVVQDGVATLECNATGKPPPTVTWE 2293
Score = 138 bits (347), Expect = 5e-32
Identities = 133/488 (27%), Positives = 187/488 (38%), Gaps = 87/488 (17%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS-HRMLLPSG 86
PPRI + I ++G PA+L C A G P PTI W K ET+ R H + G
Sbjct: 975 PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTK-----ETNALTSRGPHYNVSKEG 1029
Query: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
+L + S D G YVC A N +G + ++ ++V
Sbjct: 1030 TLLI-----AQPSAQDAGAYVCTATNTVGFS-------------------SQEMRLSVNR 1065
Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
A+ + W++ G + G L + + D+G Y C +N
Sbjct: 1066 LALSK-----------YVWEEYG----------LLPSGSLRLAQVQVGDSGHYECTASNP 1104
Query: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 266
G L V P P L V V ++ + C A G+P P + W K DG + +
Sbjct: 1105 AGSASHRYV-LGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSK-DGVVLQG 1162
Query: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV--A 324
R H IR D G Y C A N G L V EPPH+ ++
Sbjct: 1163 RGPQGSVHFAAIR---TSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERV 1219
Query: 325 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV 384
G + C A G P+P + WR+ S +P +V + G L + +V +D
Sbjct: 1220 AGENASLPCPARGTPKPQVTWRKGPSS------EPLHGQPGVAVLEEGSLFLASVSPADS 1273
Query: 385 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG--PVNQTVAVDGTFVLSCVATGS 442
G Y CQ N GS +A L V PP IR+ N + + L C A G
Sbjct: 1274 GDYECQATNEVGSTSRRAKLVV------YVPPSIREDGRKANVSGMAGQSLTLECDANGF 1327
Query: 443 PVPTILWRKDGVLVST--------------QDSRIKQLENG-VLQIRYAKLGDTGRYTCI 487
PVP I+W KD LV Q + L+ G L + GD+G Y+C
Sbjct: 1328 PVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCR 1387
Query: 488 ASTPSGEA 495
A +G A
Sbjct: 1388 AENQAGTA 1395
Score = 131 bits (330), Expect = 5e-30
Identities = 94/281 (33%), Positives = 129/281 (45%), Gaps = 19/281 (6%)
Query: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
P D + G+ L C A G PTP I W T D P + + G R
Sbjct: 4135 PGDRSLRLGDRLWLRCAARGSPTPRIGW--------TVNDRPVTEGVSEQDGGSTLQRAA 4186
Query: 95 HGRKSRPDEGVYVCVARNYLG--EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 152
SR D G YVC A N +G +AVS E +L+ + S ++ VG ++C
Sbjct: 4187 ---VSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAF---SYLVEPVGGSIQLDC 4240
Query: 153 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 212
RG P P I W KDG PL R ++ G L I T + DAG+Y C+ N +G +
Sbjct: 4241 VV-RGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK- 4298
Query: 213 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR-YEIR 271
+V L + P F P ++ V D +C+A G+P PT+ W + L SR
Sbjct: 4299 KVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTL 4358
Query: 272 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 312
D +L + V GD G+Y CVA N++G A A A L V+ P
Sbjct: 4359 PDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399
Score = 71.6 bits (174), Expect = 6e-12
Identities = 62/240 (25%), Positives = 101/240 (42%), Gaps = 19/240 (7%)
Query: 257 RKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
R+ + L + R ++ + + +I + + + G+Y C A + G A A + V +PP +
Sbjct: 461 RRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQL 520
Query: 316 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375
V + V+ G T C G + W R+ P S+ R V+Q DL+
Sbjct: 521 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWR-------VLPASTGR--VAQLADLS 571
Query: 376 --ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 433
I+ + +D G Y C N G +L V R P + +Q +
Sbjct: 572 LEISGIIPTDGGRYQCVASNANGVTRASVWLLV------REAPQVSIHTSSQHFSQGVEV 625
Query: 434 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 493
+SC A+G P P I W ++ + +DSRI G L I+ D G Y+C A+ G
Sbjct: 626 KVSCSASGYPTPHISWSRESQALQ-EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVG 684
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 207 bits (528), Expect = 5e-53
Identities = 220/863 (25%), Positives = 344/863 (39%), Gaps = 106/863 (12%)
Query: 13 LICLCSGSRLRQEDFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERV 69
++CL S L P ++ PS ++ S+ + LNC+ +G P P I W G V
Sbjct: 14 ILCLADDSTLHG----PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDV 69
Query: 70 ETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL 129
+T D R + GSL +++ D G Y C A N G VS A L+ A L
Sbjct: 70 DTGMD----FRYSVVEGSL----LINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYL 121
Query: 130 RDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGGKLMI 188
+ + S V V G+ V+ C PP E + +W + P D ++ G L I
Sbjct: 122 DNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYI 181
Query: 189 TYTRKSDAGKYVCVGTNMVGERESEVAELTVLER---------PSF-VKRPSNLAVTVDD 238
KSD G Y CV TN V + ++ R P V+ P +
Sbjct: 182 AKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGA 241
Query: 239 SAEFKCEARGDPVPTVRWRKDDGE-LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMV 297
+ + +C A G+PVPT+ WR+ DG+ + + + + L+I D G Y CVAEN
Sbjct: 242 TVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSR 301
Query: 298 GKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357
GK A LT P+++ K D VA+ V ++C+A G P+P W + G
Sbjct: 302 GKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNG-------- 353
Query: 358 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 417
+P + R + Q G L IT V SD G Y C N G I + A L V V D +
Sbjct: 354 EPLLTRDRIQIEQ-GTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTL 412
Query: 418 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477
+++ + V V G V+ C SP P W+K G + ++ RI E+G L+I
Sbjct: 413 LKRVTL---VKVGGEVVIECKPKASPKPVYTWKK-GRDILKENERITISEDGNLRIINVT 468
Query: 478 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 537
D G YTCIA+ G A+ + + V++ + PP D + S +VT
Sbjct: 469 KSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLD 528
Query: 538 VTLSWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLV 595
+ +W + N + F G S+ + N++ LK Y+ +V
Sbjct: 529 IVFTW--SFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQ--------LKHAGKYVCMV 578
Query: 596 R-------AANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLS 648
+ AA + P + V ++ T+ + + +++ + +
Sbjct: 579 QTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYV----IQA 634
Query: 649 SSSIEVHW-TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVN 707
+ V W V + I G G N W+ +E RT A N + I +
Sbjct: 635 RTPFSVGWQAVSTVPELIDGKTFTATVVGLN----PWVEYEFRTVAANVIGIGE------ 684
Query: 708 YEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQ 767
+RP SE + +T E P P VS G+ + ++++W+ PE+ Q
Sbjct: 685 ---PSRP---------SEKR--RTEEALPEVTP--ANVSGGGGSKSELVITWETVPEELQ 728
Query: 768 NGMVQEY---------KVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTG 818
NG Y +W L + + D S + + P + V+V
Sbjct: 729 NGRGFGYVVAFRPYGKMIWML------TVLASADASRYVFRNESVHPFSPFEVKVGVFNN 782
Query: 819 AGSGVKSEPQFIQLDAHGNPVSP 841
G G S P + A P P
Sbjct: 783 KGEGPFS-PTTVVYSAEEEPTKP 804
Score = 204 bits (520), Expect = 4e-52
Identities = 216/780 (27%), Positives = 352/780 (45%), Gaps = 105/780 (13%)
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASL---EVAILRDDFR------- 134
+G+L+ ++ + D G Y CV N V+++ L ILR+D
Sbjct: 176 TGNLYIAKV-----EKSDVGNYTCVVTN----TVTNHKVLGPPTPLILRNDGVMGEYEPK 226
Query: 135 ---QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITY 190
Q P V A G +EC G+P PTI W++ DG P+ K R G L I
Sbjct: 227 IEVQFPETVPTAKGATVKLECFA-LGNPVPTIIWRRADGKPIARKARRHK-SNGILEIPN 284
Query: 191 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 250
++ DAG Y CV N G+ + +LT +P+++++ +++ V ++++ ++C+A G P
Sbjct: 285 FQQEDAGLYECVAENSRGKNVAR-GQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRP 343
Query: 251 VPTVRWRKDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
PT +W K+ GE L + R +I + TL I V D G Y C+AEN G ++A L+V
Sbjct: 344 KPTYKWLKN-GEPLLTRDRIQI-EQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSV 401
Query: 309 -QEPPHF--VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 365
P F + R +V +G V +C+ +P+P W++ +++L + + R
Sbjct: 402 IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKK--GRDIL------KENER 453
Query: 366 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 425
++S+ G+L I NV +SD G Y C N G+ + L V D P + P +
Sbjct: 454 ITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD------PTRVMVPPSSM 507
Query: 426 TVAVDGTFVLSCVATGSPVPTIL--WRKDGVLVSTQDS-----RIKQLEN-GVLQIRYAK 477
V V + VL C T I+ W +G L+ R+ ++ G L IR +
Sbjct: 508 DVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQ 567
Query: 478 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 537
L G+Y C+ T + +A + V+ PP P P A + E+TD T
Sbjct: 568 LKHAGKYVCMVQTSVDRLSAAADLIVRG------PPGP------PEAVTIDEITDT---T 612
Query: 538 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE-----NVKTETSAIKGLKPNAIYL 592
LSW+P ++ + T Y+I+A + S WQ V+ + KT T+ + GL P Y
Sbjct: 613 AQLSWRPGPDNHSPITMYVIQARTPFS-VGWQAVSTVPELIDGKTFTATVVGLNPWVEYE 671
Query: 593 FLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSI 652
F AAN GI +PS+ S+ +T++ LP V V G S S +
Sbjct: 672 FRTVAANVIGIGEPSRPSEKRRTEEALPE---VTPANVSGGGG------------SKSEL 716
Query: 653 EVHW-TVDQQSQYIQ--GYKILYRPSGANHGESDWLVFEVRTPAKNSVVI--PDLRKGVN 707
+ W TV ++ Q + GY + +RP +G+ W++ + + + V +
Sbjct: 717 VITWETVPEELQNGRGFGYVVAFRP----YGKMIWMLTVLASADASRYVFRNESVHPFSP 772
Query: 708 YEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQ 767
+E+K F N+ +G S + EE P+ PP ++ + T I V W P E +
Sbjct: 773 FEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPP--ASIFARSLSATDIEVFWASPLEKNR 830
Query: 768 NGMVQEYKVWCLGNETRYHINKTVD--GSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 825
G +Q Y+V +E + + + G+ S I L + Y + V A AG+G S
Sbjct: 831 -GRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSS 889
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 206 bits (523), Expect = 2e-52
Identities = 140/400 (35%), Positives = 186/400 (46%), Gaps = 21/400 (5%)
Query: 111 RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS 170
R G +V+ E+ R P D V G C+ G+P+P I W ++ +
Sbjct: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284
Query: 171 PLDDK-DERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL---ERPSF 225
L K D R+ + G LMI T+++D G Y C+ N+ GE +++ L RP+F
Sbjct: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
Query: 226 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDGELPKS-RYEIRDDHTLKIRKVTA 283
V +P N V V +S +C A G P P + W R D LP R I L I+ V
Sbjct: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
Query: 284 GDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAI 343
GD G Y C A N + A+A + VQ P F V P+D+VV G+TV FQCEA GNP P I
Sbjct: 405 GDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVI 464
Query: 344 FWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAY 403
W + GSQ + R V +G L I+ V D G Y CQ +N+ GS A+
Sbjct: 465 AWTKGGSQLSV--------DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAH 516
Query: 404 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRI 463
L + R PV P + TV V L C + G P P I W KDGV V T+ +
Sbjct: 517 L----TVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQV-TESGKF 571
Query: 464 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 503
G L I D GRY C+A G A+ S + V
Sbjct: 572 HISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
Score = 190 bits (483), Expect = 8e-48
Identities = 131/400 (32%), Positives = 180/400 (45%), Gaps = 32/400 (8%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
PRI P D V+ G C+AEG P P I W + + D S LL G+L
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
Query: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV--AILRDDFRQNPSDVMVAVGE 146
D+G+Y C+A+N GE + +L + R F P + V VGE
Sbjct: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
Query: 147 PAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGT 204
+EC GHP P ISW + D +PL D R+ I G L I + D+G+Y C T
Sbjct: 358 SVTLECS-ATGHPPPRISWTRGDRTPL-PVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
Query: 205 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 264
N + + A + V P F P + V + +F+CEA+G+P P + W K +L
Sbjct: 416 NNI-DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS 474
Query: 265 -KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE--PPHFVVKPRDQ 321
R+ + TL+I V D G Y C A N++G + A LTVQ P F P D
Sbjct: 475 VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT 534
Query: 322 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 381
V +G V C + G P+PAI W ++G Q S +F +S G LTI +V
Sbjct: 535 TVEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVGP 586
Query: 382 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 421
+D G Y C N GS V+ V++ P V R G
Sbjct: 587 ADAGRYECVARNTIGS------ASVSMVLSVNVPDVSRNG 620
Score = 143 bits (360), Expect = 2e-33
Identities = 114/413 (27%), Positives = 173/413 (41%), Gaps = 27/413 (6%)
Query: 221 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK---SRYEIRDDHTLK 277
ERP P + VT ++ F C A G+P P + W +++ EL SR + DD TL
Sbjct: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
Query: 278 IRKVTAGDMGSYTCVAENMVGKAEAS-ATLTV---QEPPHFVVKPRDQVVALGRTVTFQC 333
I+ D G Y C+A+N+ G+ + TL P FV++P++ V +G +VT +C
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
Query: 334 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 393
ATG+P P I W R G + P R +++ +G L I NV + D G Y C N
Sbjct: 364 SATGHPPPRISWTR-GDRT------PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
Query: 394 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG 453
S+ A++ V + P P ++ V T C A G+P P I W K G
Sbjct: 417 NIDSVHATAFIIVQAL------PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGG 470
Query: 454 VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 513
+S D R L +G L+I L D G+Y C A G A++ VQ PV
Sbjct: 471 SQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 529
Query: 514 RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE 573
P+D + A + + ++W G T H S + T+ +
Sbjct: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWN---KDGVQVTE---SGKFHISPEGFLTIND 583
Query: 574 NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 626
+ + + N I V + + D S+ DP ++ VD
Sbjct: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVD 636
Score = 100 bits (249), Expect = 1e-20
Identities = 69/205 (33%), Positives = 94/205 (45%), Gaps = 12/205 (5%)
Query: 304 ATLTVQE----PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 359
AT+T +E P +P+D V G TV F C A GNP+P I W R ++ +
Sbjct: 234 ATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM----- 288
Query: 360 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 419
++ SR ++ G L I N Q +D G Y C NVAG + T+ RP VI+
Sbjct: 289 -KTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ 347
Query: 420 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 479
P N V V + L C ATG P P I W + D R+ +G L I+ G
Sbjct: 348 --PQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQG 405
Query: 480 DTGRYTCIASTPSGEATWSAYIEVQ 504
D+G Y C A+ +A+I VQ
Sbjct: 406 DSGEYACSATNNIDSVHATAFIIVQ 430
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 204 bits (518), Expect = 7e-52
Identities = 227/856 (26%), Positives = 347/856 (40%), Gaps = 106/856 (12%)
Query: 40 VSKGEPATLNC-KAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
VS GE A + + P P + W++ G ++ P S + +L L V
Sbjct: 124 VSHGEAAVIRAPRIASFPQPQVTWFRDGRKIP-----PSSRIAITLENTLVILSTV---- 174
Query: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVM-------------VAVG 145
PD G Y A N + N + + L + P+D + VA
Sbjct: 175 -APDAGRYYVQAVN---DKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGT 230
Query: 146 EPAVMECQP-PRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT 204
+EC R + I WKKDG L I+ +L I SDAG Y C
Sbjct: 231 SEVTLECVANARPLIKLHIIWKKDGVLLSGG---ISDHNRRLTIPNPTGSDAGYYECEAV 287
Query: 205 NMVGERESEV--AELTVLERPSFVKRPS-NLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
S V A L+VLE P FVK P ++ ++ + C+A+G P P++ W KD
Sbjct: 288 LRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA 347
Query: 262 --ELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE-PPHFVVK 317
E+ K +R+ R+D L+I + D G + C A N G+ + S L V P+
Sbjct: 348 VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG 407
Query: 318 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 377
P D V G +V CE +G P+PAI W++ S Q P RF+ ++G L I+
Sbjct: 408 PLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLP----RFTPLESGSLLIS 463
Query: 378 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 437
SD G Y C N G + +A ++ R I + P +Q+V + C
Sbjct: 464 PTHISDAGTYTCLATNSRG--VDEASADLVVWARTR----ITKPPQDQSVIKGTQASMVC 517
Query: 438 VATGSPVPTI--LWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 494
T P TI +W KDG + T+ RI+ NG L I GD G YTC + G
Sbjct: 518 GVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGN 577
Query: 495 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVT--DVSRNTVTLSWQPNLNSGATP 552
+ SA++ V++ +P AP P T V R + L+W + +
Sbjct: 578 DSRSAHLRVRQ---------------LPHAPEHPVATLSTVERRAINLTWTKPFDGNSPL 622
Query: 553 TSYIIEAFSHASGSSWQTVAENV--KTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 610
YI+E + + W + +V K + +KGL P Y F + A N G S+ +
Sbjct: 623 IRYILE--MSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT 680
Query: 611 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW---TVDQQSQYIQG 667
+ V + PT+ Q + + ++ SI + W Q+ ++G
Sbjct: 681 ERVSLPEEPPTA------PPQNVIASG---------RTNQSIMIQWQPPPESHQNGILKG 725
Query: 668 YKILYRPSGANHGESDWLVFEVRTPAK-NSVVIPDLRKGVNYEIKARPFFNEFQGADSEI 726
Y I Y +G G F+ T A N++++ DL NYEI+ + + G S
Sbjct: 726 YIIRYCLAGLPVGYQ----FKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSK 781
Query: 727 KFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYH 786
TL+ P+ PP V N T I +W P NG+ Q YK+ E
Sbjct: 782 VTEWTLQGVPTVPPGNVHAEAT--NSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEE 839
Query: 787 INKTVDGSTF--SVVIPFLVPGIR----YSVEVAASTGAGSGVKSEPQFIQLDAHGNPVS 840
+ F S+ + F V G++ Y V T G G +S PQ ++ H +
Sbjct: 840 VTMVTARPNFQDSIHVGF-VSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVR--THEDVPG 896
Query: 841 PEDQVSLAQQISDVVK 856
P +S ++ + +K
Sbjct: 897 PVGHLSFSEILDTSLK 912
Score = 195 bits (496), Expect = 3e-49
Identities = 220/871 (25%), Positives = 338/871 (38%), Gaps = 98/871 (11%)
Query: 24 QEDFPPRIVEHPSDLIVS-KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
Q+D P P V +G L C AEG +W + + +R +
Sbjct: 21 QDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLE---YRYM 77
Query: 83 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
+ S R G Y C+ RN +G + ++VA + F + V
Sbjct: 78 ITS------------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYM-GSFEEGEKHQSV 124
Query: 143 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 202
+ GE AV+ P+P ++W +DG + L+I T DAG+Y
Sbjct: 125 SHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQ 184
Query: 203 GTNMVG--ERESEVAELTVLE--------RPSFVKRPSNLAVTVDDS-AEFKCEARGDPV 251
N + S+ LTV P+ + P N +V S +C A P+
Sbjct: 185 AVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPL 244
Query: 252 PTVR--WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA---ENMVGKAEASATL 306
+ W+KD L + + L I T D G Y C A + V A L
Sbjct: 245 IKLHIIWKKDGVLLSGGISD--HNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 302
Query: 307 TVQEPPHFVVKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 365
+V EPP FV +P + A + + V C+A G P P+I W ++ + + +R
Sbjct: 303 SVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDA------AVVEVEKLTR 356
Query: 366 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 425
F G L I+ + D G + C N AG + T YL VT + P I +GP++
Sbjct: 357 FRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI-----APNITRGPLDS 411
Query: 426 TVAVDGTFVLSCVATGSPVPTILWRKDGVLV---STQDSRIKQLENGVLQIRYAKLGDTG 482
TV + VL+C +G+P P I W+K ++ S Q R LE+G L I + D G
Sbjct: 412 TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG 471
Query: 483 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 542
YTC+A+ G SA + V +PP+ A VT R T+ W
Sbjct: 472 TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIW 531
Query: 543 QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYG 602
+ + + T + I + S QT + ++ T T + N R+A+
Sbjct: 532 EKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGND-----SRSAHLRV 586
Query: 603 ISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQS 662
P PV T + + ++ + GN+ L + +L S WTV
Sbjct: 587 RQLPHAPEHPVATLSTV-ERRAINLTWTKPFDGNSPLIRY---ILEMSENNAPWTV---- 638
Query: 663 QYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGA 722
L+ V P SV + L +Y+ + + +G
Sbjct: 639 ----------------------LLASV-DPKATSVTVKGLVPARSYQFRLCAVNDVGKGQ 675
Query: 723 DSEIKFAKTL-EEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV-WCL- 779
S+ +L EE P+APPQ V S +I++ WQPPPE QNG+++ Y + +CL
Sbjct: 676 FSKDTERVSLPEEPPTAPPQNVIASGR--TNQSIMIQWQPPPESHQNGILKGYIIRYCLA 733
Query: 780 GNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPV 839
G Y D ++++ L+ Y +EVAA AG GV S + + G P
Sbjct: 734 GLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSS-KVTEWTLQGVPT 792
Query: 840 SPEDQVSLAQQISDVVK------QPAFIAGI 864
P V S ++ P FI GI
Sbjct: 793 VPPGNVHAEATNSTTIRFTWNAPSPQFINGI 823
Score = 137 bits (345), Expect = 8e-32
Identities = 197/835 (23%), Positives = 310/835 (37%), Gaps = 113/835 (13%)
Query: 29 PRIVEHPSDLIVSKG-EPATLNCKAEGRPTPTIE--WYKGGERVETDKDDPRSHRMLLPS 85
P I+ P + V G TL C A RP + W K G + D + R+ +P+
Sbjct: 215 PTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISD-HNRRLTIPN 273
Query: 86 GSLFFLRIVHGRKSRPDEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 143
+ D G Y C V R+ +V A L V + F + P + A
Sbjct: 274 ------------PTGSDAGYYECEAVLRSSSVPSVVRGAYLSV-LEPPQFVKEPERHITA 320
Query: 144 VGEPAV-MECQPPRGHPEPTISWKKDGSPLD-DKDERITIRG-GKLMITYTRKSDAGKYV 200
E V + CQ +G P P+I+W KD + ++ +K R R G L I+ D G +
Sbjct: 321 EMEKVVDIPCQA-KGVPPPSITWYKDAAVVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQ 379
Query: 201 CVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 260
C N GE ++ P+ + P + V S CE G P P + W+K +
Sbjct: 380 CFARNAAGEVQTSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQKGE 439
Query: 261 -----GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
G + R+ + +L I D G+YTC+A N G EASA L V
Sbjct: 440 RILASGSVQLPRFTPLESGSLLISPTHISDAGTYTCLATNSRGVDEASADLVVWARTRIT 499
Query: 316 VKPRDQVVALGRTVTFQCEATGNPQPAI--FWRREGSQNLLFSYQPPQSSSRFSVSQTGD 373
P+DQ V G + C T +P+ I W ++G+ +S R + + G
Sbjct: 500 KPPQDQSVIKGTQASMVCGVTHDPRVTIRYIWEKDGAT------LGTESHPRIRLDRNGS 553
Query: 374 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ-------T 426
L I+ D+G Y C+ ++ G+ A+L V + PV V + T
Sbjct: 554 LHISQTWSGDIGTYTCRVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRAINLTWT 613
Query: 427 VAVDGT-----FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 481
DG ++L +P +L D S + + Q R + D
Sbjct: 614 KPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARS--YQFRLCAVNDV 671
Query: 482 GRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 541
G+ T + +P +PP N+I S + ++ +
Sbjct: 672 GKGQFSKDT-------------ERVSLPEEPPTAPPQNVIASGRTN--------QSIMIQ 710
Query: 542 WQPNLNS--GATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAI----YLFLV 595
WQP S YII +Q +N+ T+ L + I Y V
Sbjct: 711 WQPPPESHQNGILKGYIIRYCLAGLPVGYQF--KNI-TDADVNNLLLEDLIIWTNYEIEV 767
Query: 596 RAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVH 655
A N+ G+ S Q V G H + +S++I
Sbjct: 768 AAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEAT----------------NSTTIRFT 811
Query: 656 WTVDQQSQYI----QGYKILYRPSGANHGESDWLVFEVRTPAKNSV---VIPDLRKGVNY 708
W Q+I QGYK++ + E + + R ++S+ + L+K Y
Sbjct: 812 WNAPSP-QFINGINQGYKLI---AWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEY 867
Query: 709 EIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQN 768
F G S + +T E+ P P G +S ++ T++ VSWQ P E +N
Sbjct: 868 FTSVLCFTTPGDGPRSTPQLVRTHEDVPG--PVG-HLSFSEILDTSLKVSWQEPGE--KN 922
Query: 769 GMVQEYKV-WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 822
G++ Y++ W N T + + T + L Y++EVAA T G G
Sbjct: 923 GILTGYRISWEEYNRTNTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQG 977
Score = 91.3 bits (225), Expect = 7e-18
Identities = 90/338 (26%), Positives = 141/338 (41%), Gaps = 55/338 (16%)
Query: 522 PSAPSKPEVT--DVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET 579
P PS+P V DV +V LSW+P + G +P Y W + +V
Sbjct: 1400 PQPPSRPMVQQEDVRARSVLLSWEPG-SDGLSPVRYYTIQTRELPSGRWALHSASVSHNA 1458
Query: 580 SA--IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNA 637
S+ + LKP Y F V+A N G S+ S+ S+ + T P
Sbjct: 1459 SSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEA-------------- 1504
Query: 638 VLHLHNPTVLS-----SSSIEVHW---TVDQQSQYIQGYKILYRP-----------SGAN 678
PT+LS ++S+ + W D+ + + G++I YR G N
Sbjct: 1505 ------PTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGIN 1558
Query: 679 HGESDWL----VFEVRTPAKNSVV---IPDLRKGVNYEIKARPFFNEFQGADSEIKFAKT 731
+ + W ++ +R ++ S+ + +L K YEI+ + +G S +
Sbjct: 1559 NPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFV 1618
Query: 732 LEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCLGNETRYHINK 789
E P+A P+ V V + T + V+W+PPP D+QNG +Q YK+ W K
Sbjct: 1619 GEAVPTAAPRNVVV--HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVK 1676
Query: 790 TVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 827
T+ + SV + L Y V VAA AG G +S P
Sbjct: 1677 TLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTP 1714
Score = 82.4 bits (202), Expect = 3e-15
Identities = 90/388 (23%), Positives = 150/388 (38%), Gaps = 41/388 (10%)
Query: 466 LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 525
L N L+ R L YT + + + GVP + P P P
Sbjct: 946 LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGP---------P 996
Query: 526 SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHA--SGSSWQTV---AENVKTETS 580
+ ++++ +VTL ++P + + + +++EA G W + + +
Sbjct: 997 TNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSM 1056
Query: 581 AIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLH 640
+ L P Y F +R N G S PSQ S ++T P ++ A +
Sbjct: 1057 EVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPP------------DMAPANVS 1104
Query: 641 LHNPTVLSSSSIEVHWTVDQQSQY-----IQGYKILYRPSGANHGESDWLVFEVRTPAKN 695
L S +S+ + W + +Y GYKI Y S HG++ L V+ +
Sbjct: 1105 LR---TASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSD-GHGKT--LSHVVQDRVER 1158
Query: 696 SVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAI 755
I DL + Y ++ + F G S+ +T E PS+ P V+ +++
Sbjct: 1159 DYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALAT--TSSSM 1216
Query: 756 LVSWQPPPEDTQNGMVQEYKVWC--LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEV 813
LV W PE +NG+V YKV ++T+ S+ S + L + Y V+V
Sbjct: 1217 LVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQV 1276
Query: 814 AASTGAGSGVKSEPQFIQLDAHGNPVSP 841
A T G G S P ++ P P
Sbjct: 1277 LAFTRIGDGSPSHPPILERTLDDVPGPP 1304
Score = 51.2 bits (121), Expect = 8e-06
Identities = 63/278 (22%), Positives = 117/278 (42%), Gaps = 31/278 (11%)
Query: 507 GVPVQPP---RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHA 563
G P PP R D +P P +V +V L WQP +Y I +
Sbjct: 1285 GSPSHPPILERTLDD--VPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNT 1342
Query: 564 SGSSWQTV---AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLP 620
+ ++ TV A + + T+ GLKP ++YLF + A G + ++ V T +
Sbjct: 1343 TTANTATVEVLAPSARQYTAT--GLKPESVYLFRITAQTRKGWGEAAEAL--VVTTEKRD 1398
Query: 621 TSQGVDHKQVQRE--LGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGAN 678
Q VQ+E +VL P S + ++T+ Q++ + + + +
Sbjct: 1399 RPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVR-YYTI--QTRELPSGRWALHSASVS 1455
Query: 679 HGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA 738
H S ++V ++ + +KA + + ++ E + TL+ AP
Sbjct: 1456 HNASSFIVDRLKP-----------FTSYKFRVKATNDIGDSEFSE-ESESLTTLQAAPDE 1503
Query: 739 PPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 776
P ++V+ + T++L+ WQPP ED NG++ +++
Sbjct: 1504 APTILSVTPH--TTTSVLIRWQPPAEDKINGILLGFRI 1539
Score = 50.1 bits (118), Expect = 2e-05
Identities = 73/317 (23%), Positives = 118/317 (37%), Gaps = 39/317 (12%)
Query: 523 SAPSKPEVTDVSRNTVTLSWQPNL--NSGATPTSYIIEAFSHASGSSWQTVAENVKTETS 580
+AP V + + ++W+P + Y I + G+ + V E S
Sbjct: 1625 AAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENS 1684
Query: 581 A-IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTS-QGVDHKQVQRELGNAV 638
+K L Y+ V A NA G P +TQ P++ V +
Sbjct: 1685 VKLKNLTGYTAYMVSVAAFNAAG-DGPRSTPTQGQTQQAAPSAPSSVKFSE--------- 1734
Query: 639 LHLHNPTVLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV 697
L+++S+ V W Q + ++GY+++Y P G S + +V+ + +
Sbjct: 1735 --------LTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWL 1786
Query: 698 VIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAP-PQGVTVSKNDGNGTAIL 756
+ DL +GV Y + R + EI+ T AP P GV + +AI
Sbjct: 1787 KVKDLAEGVTYRFRIRAKTFTY---GPEIEANVTTGPGEGAPGPPGVPIIVR--YSSAIA 1841
Query: 757 VSWQPPPEDTQNGMVQEYKVWCLGNETRY------HINKTVDGSTFSVVIPFLVPGIRYS 810
+ W D G + Y + ++ I K V TFS+ I L PG+ Y
Sbjct: 1842 IHWS--SGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDI--LKPGVSYD 1897
Query: 811 VEVAASTGAGSGVKSEP 827
V A G G S P
Sbjct: 1898 FRVIAVNDYGFGTPSSP 1914
Score = 40.0 bits (92), Expect = 0.018
Identities = 34/121 (28%), Positives = 48/121 (39%), Gaps = 9/121 (7%)
Query: 506 FGVPVQPPRPTDPNLIPSAPSKPEVTDVSR--NTVTLSWQPNLNSGATPTSYIIEAFSHA 563
+G ++ T P AP P V + R + + + W T Y+IEA
Sbjct: 1808 YGPEIEANVTTGPG--EGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSD 1865
Query: 564 SGSSWQTVAENVKTETSA----IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVL 619
G W + +++ E S+ + LKP Y F V A N YG PS S V Q
Sbjct: 1866 EGL-WDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKAN 1924
Query: 620 P 620
P
Sbjct: 1925 P 1925
Score = 32.3 bits (72), Expect = 3.8
Identities = 56/230 (24%), Positives = 93/230 (40%), Gaps = 38/230 (16%)
Query: 497 WSAY-IEVQEFGVPVQPPRPTDPN-----LIPSAPSKPEVTDVSRNTVTLSWQ-PNLNSG 549
++AY + V F PR T PSAPS + ++++ +V +SW+ P +G
Sbjct: 1693 YTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752
Query: 550 ATPTSYII-EAFSHASGSSWQTVAENVKTETS---AIKGLKPNAIYLFLVRAAN-AYGIS 604
++ E S G S + V +VK + +K L Y F +RA YG
Sbjct: 1753 ILEGYRLVYEPCSPVDGVS-KIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPE 1811
Query: 605 DPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLS-SSSIEVHWTV-DQQS 662
+ ++ + P GV P ++ SS+I +HW+ D
Sbjct: 1812 IEANVT--TGPGEGAPGPPGV------------------PIIVRYSSAIAIHWSSGDPGK 1851
Query: 663 QYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD-LRKGVNYEIK 711
I Y I RPS + G D L+ ++ + D L+ GV+Y+ +
Sbjct: 1852 GPITRYVIEARPS--DEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFR 1899
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 203 bits (517), Expect = 1e-51
Identities = 220/854 (25%), Positives = 352/854 (41%), Gaps = 92/854 (10%)
Query: 21 RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR 80
RL E P E + V +GE L C P ++ + + +D+ +
Sbjct: 124 RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT-- 181
Query: 81 MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------- 132
+ +G+L+F ++ + + Y+C A + +++ + +
Sbjct: 182 -MGQNGNLYFANVL----TSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPR 236
Query: 133 --FRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK--LM 187
F N S +VA+ G+P V+EC G P PTI W + P+ +R+T + L
Sbjct: 237 LLFPTNSSSHLVALQGQPLVLECIA-EGFPTPTIKWLRPSGPMPA--DRVTYQNHNKTLQ 293
Query: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
+ + D G+Y C+ N +G +TV P ++ +P + ++A C+ +
Sbjct: 294 LLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQ 352
Query: 248 GDPVPTVRWRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304
G P P V WR + EL K + L + V D C A N G A+A
Sbjct: 353 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANA 412
Query: 305 TLTVQEPPHFVVKPRDQ--VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS 362
+ V + P ++ +Q + G T C+A G P P++ W E +L
Sbjct: 413 YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-------Q 465
Query: 363 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 422
RF G L I ++Q +D G Y C N ++ A L+V D I QGP
Sbjct: 466 DERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ------ITQGP 519
Query: 423 VNQTVAVDGTFVLSCVATGSPV--PTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLG 479
+ +C A+ P P+I WR DG L DS +E+G L I
Sbjct: 520 RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYS 579
Query: 480 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVT 539
D G Y+C+AST A + V V P P P L+ S ++ ++++ V
Sbjct: 580 DQGNYSCVASTELDVVESRAQLLV------VGSPGPV-PRLVLS-----DLHLLTQSQVR 627
Query: 540 LSWQPNLNSGATPTSYIIE-AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAA 598
+SW P + A Y IE + W ++ + +TS L P Y F V A
Sbjct: 628 VSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAI 687
Query: 599 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 658
N YG +PS +S+ V T + P VD K E N V+ + + W +
Sbjct: 688 NKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVI----------TWKPLRW-M 736
Query: 659 DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNE 718
D + +Q Y++ +RP G W V P +V+ + V YEIK + ++
Sbjct: 737 DWNAPQVQ-YRVQWRPQGT---RGPWQEQIVSDP---FLVVSNTSTFVPYEIKVQAVNSQ 789
Query: 719 FQGADSEIKFAKTLEEAPSAPP--QGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 776
+G + ++ + E+ P A P +G+ + N +A+LV W+P G ++ Y V
Sbjct: 790 GKGPEPQVTIGYSGEDYPQAIPELEGIEIL----NSSAVLVKWRPVDLAQVKGHLRGYNV 845
Query: 777 --WCLGNETRY---HINK---TVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQ 828
W G++ ++ HI+K V +T SV++ L P Y +EV A G GSG SE
Sbjct: 846 TYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE-- 903
Query: 829 FIQLDAHGNPVSPE 842
F G P PE
Sbjct: 904 FTFSTPEGVPGHPE 917
Score = 191 bits (486), Expect = 4e-48
Identities = 148/509 (29%), Positives = 227/509 (44%), Gaps = 35/509 (6%)
Query: 28 PPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
PP I E P L+V + +L C+A G+P W + G + ++ + SG
Sbjct: 29 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88
Query: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
S F + + ++ +G+Y C A N LG A+SH L ++ V V GE
Sbjct: 89 S-FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 147
Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDA-GKYVC--- 201
V+ C PP I W +DER+T+ + G L SD Y+C
Sbjct: 148 SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 207
Query: 202 -VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF----------KCEARGDP 250
GT + ++E +L V S + R L + S+ +C A G P
Sbjct: 208 FPGTRTIIQKEP--IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 265
Query: 251 VPTVRWRKDDGELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
PT++W + G +P R ++ + TL++ KV D G Y C+AEN +G A + +TV+
Sbjct: 266 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 325
Query: 310 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 369
P+++ KP+ + G T C+ G PQP + WR G + ++ +
Sbjct: 326 AAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPVEELAKDQKYRI- 379
Query: 370 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT-VA 428
Q G L ++NVQ SD C+ N G ++ AY+ V + P ++ NQT +A
Sbjct: 380 QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL----PAKILTAD--NQTYMA 433
Query: 429 VDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 487
V G T L C A G+PVP++ W + QD R NG L IR + DTGRY C+
Sbjct: 434 VQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCL 493
Query: 488 ASTPSGEATWSAYIEVQEFGVPVQPPRPT 516
A+ T A ++V++ Q PR T
Sbjct: 494 AANDQNNVTIMANLKVKDATQITQGPRST 522
Score = 174 bits (441), Expect = 6e-43
Identities = 201/825 (24%), Positives = 338/825 (40%), Gaps = 87/825 (10%)
Query: 26 DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
D PR++ S L+ +G+P L C AEG PTPTI+W + + D+ ++H
Sbjct: 232 DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKT 291
Query: 83 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVM 141
L L++ D+G Y C+A N LG A ++ ++E A + P +
Sbjct: 292 LQ-----LLKV-----GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY---WLHKPQSHL 338
Query: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD--KDERITIRGGKLMITYTRKSDAGKY 199
GE A ++CQ +G P+P ++W+ +G P+++ KD++ I+ G L+++ + SD
Sbjct: 339 YGPGETARLDCQV-QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVT 397
Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWR 257
C N G + A + V++ P+ + N +A C+A G PVP+V+W
Sbjct: 398 QCEARNRHGLLLAN-AYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 456
Query: 258 KDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
+DG L R+ + TL IR + A D G Y C+A N A L V++
Sbjct: 457 DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 516
Query: 316 VKPRDQVVALGRTVTFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 373
PR + G VTF C+A+ +P QP+I WR +G Q S ++ + + G
Sbjct: 517 QGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFI-EDGR 570
Query: 374 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 433
L I ++ SD G Y C + ++A L V V GPV + V D
Sbjct: 571 LVIHSLDYSDQGNYSCVASTELDVVESRAQLLV----------VGSPGPVPRLVLSDLHL 620
Query: 434 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ-IRYAKLGDTGRYTCIASTPS 492
+ S P + D + E + K+ T + +P
Sbjct: 621 LTQSQVRVSWSPA---EDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPY 677
Query: 493 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS-----RNTVTLSWQPN-- 545
T+ + ++G P +P ++ + P A + DV + ++W+P
Sbjct: 678 VHYTFRV-TAINKYG-PGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 735
Query: 546 LNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD 605
++ A Y ++ + WQ + V + Y V+A N+ G
Sbjct: 736 MDWNAPQVQYRVQWRPQGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGP 793
Query: 606 PSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT---VDQQS 662
Q++ G D+ Q A+ L +L+SS++ V W + Q
Sbjct: 794 EPQVTIGYS---------GEDYPQ-------AIPELEGIEILNSSAVLVKWRPVDLAQVK 837
Query: 663 QYIQGYKILYRPSGANHGESDWLVFE--VRTPAKN-SVVIPDLRKGVNYEIKARPFFNEF 719
+++GY + Y G+ S + + V PA SV++ LR +Y ++ + F
Sbjct: 838 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 897
Query: 720 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDTQNGMVQEYKVW 777
G SE F+ T E P P + + T++L+ WQPP G V Y
Sbjct: 898 SGPASEFTFS-TPEGVPGHPE---ALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPL 953
Query: 778 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 822
G + + N D + + L P +RY ++ A+T G G
Sbjct: 954 DEGGKGQLSFNLR-DPELRTHNLTDLSPHLRYRFQLQATTKEGPG 997
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 203 bits (517), Expect = 1e-51
Identities = 220/854 (25%), Positives = 352/854 (41%), Gaps = 92/854 (10%)
Query: 21 RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR 80
RL E P E + V +GE L C P ++ + + +D+ +
Sbjct: 129 RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT-- 186
Query: 81 MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------- 132
+ +G+L+F ++ + + Y+C A + +++ + +
Sbjct: 187 -MGQNGNLYFANVL----TSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPR 241
Query: 133 --FRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK--LM 187
F N S +VA+ G+P V+EC G P PTI W + P+ +R+T + L
Sbjct: 242 LLFPTNSSSHLVALQGQPLVLECIA-EGFPTPTIKWLRPSGPMPA--DRVTYQNHNKTLQ 298
Query: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
+ + D G+Y C+ N +G +TV P ++ +P + ++A C+ +
Sbjct: 299 LLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQ 357
Query: 248 GDPVPTVRWRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304
G P P V WR + EL K + L + V D C A N G A+A
Sbjct: 358 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANA 417
Query: 305 TLTVQEPPHFVVKPRDQ--VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS 362
+ V + P ++ +Q + G T C+A G P P++ W E +L
Sbjct: 418 YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-------Q 470
Query: 363 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 422
RF G L I ++Q +D G Y C N ++ A L+V D I QGP
Sbjct: 471 DERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ------ITQGP 524
Query: 423 VNQTVAVDGTFVLSCVATGSPV--PTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLG 479
+ +C A+ P P+I WR DG L DS +E+G L I
Sbjct: 525 RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYS 584
Query: 480 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVT 539
D G Y+C+AST A + V V P P P L+ S ++ ++++ V
Sbjct: 585 DQGNYSCVASTELDVVESRAQLLV------VGSPGPV-PRLVLS-----DLHLLTQSQVR 632
Query: 540 LSWQPNLNSGATPTSYIIE-AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAA 598
+SW P + A Y IE + W ++ + +TS L P Y F V A
Sbjct: 633 VSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAI 692
Query: 599 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 658
N YG +PS +S+ V T + P VD K E N V+ + + W +
Sbjct: 693 NKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVI----------TWKPLRW-M 741
Query: 659 DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNE 718
D + +Q Y++ +RP G W V P +V+ + V YEIK + ++
Sbjct: 742 DWNAPQVQ-YRVQWRPQGT---RGPWQEQIVSDP---FLVVSNTSTFVPYEIKVQAVNSQ 794
Query: 719 FQGADSEIKFAKTLEEAPSAPP--QGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 776
+G + ++ + E+ P A P +G+ + N +A+LV W+P G ++ Y V
Sbjct: 795 GKGPEPQVTIGYSGEDYPQAIPELEGIEIL----NSSAVLVKWRPVDLAQVKGHLRGYNV 850
Query: 777 --WCLGNETRY---HINK---TVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQ 828
W G++ ++ HI+K V +T SV++ L P Y +EV A G GSG SE
Sbjct: 851 TYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE-- 908
Query: 829 FIQLDAHGNPVSPE 842
F G P PE
Sbjct: 909 FTFSTPEGVPGHPE 922
Score = 191 bits (486), Expect = 4e-48
Identities = 148/509 (29%), Positives = 227/509 (44%), Gaps = 35/509 (6%)
Query: 28 PPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
PP I E P L+V + +L C+A G+P W + G + ++ + SG
Sbjct: 34 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93
Query: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
S F + + ++ +G+Y C A N LG A+SH L ++ V V GE
Sbjct: 94 S-FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 152
Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDA-GKYVC--- 201
V+ C PP I W +DER+T+ + G L SD Y+C
Sbjct: 153 SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 212
Query: 202 -VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF----------KCEARGDP 250
GT + ++E +L V S + R L + S+ +C A G P
Sbjct: 213 FPGTRTIIQKEP--IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 270
Query: 251 VPTVRWRKDDGELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
PT++W + G +P R ++ + TL++ KV D G Y C+AEN +G A + +TV+
Sbjct: 271 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 330
Query: 310 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 369
P+++ KP+ + G T C+ G PQP + WR G + ++ +
Sbjct: 331 AAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPVEELAKDQKYRI- 384
Query: 370 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT-VA 428
Q G L ++NVQ SD C+ N G ++ AY+ V + P ++ NQT +A
Sbjct: 385 QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL----PAKILTAD--NQTYMA 438
Query: 429 VDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 487
V G T L C A G+PVP++ W + QD R NG L IR + DTGRY C+
Sbjct: 439 VQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCL 498
Query: 488 ASTPSGEATWSAYIEVQEFGVPVQPPRPT 516
A+ T A ++V++ Q PR T
Sbjct: 499 AANDQNNVTIMANLKVKDATQITQGPRST 527
Score = 174 bits (441), Expect = 6e-43
Identities = 201/825 (24%), Positives = 338/825 (40%), Gaps = 87/825 (10%)
Query: 26 DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
D PR++ S L+ +G+P L C AEG PTPTI+W + + D+ ++H
Sbjct: 237 DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKT 296
Query: 83 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVM 141
L L++ D+G Y C+A N LG A ++ ++E A + P +
Sbjct: 297 LQ-----LLKV-----GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY---WLHKPQSHL 343
Query: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD--KDERITIRGGKLMITYTRKSDAGKY 199
GE A ++CQ +G P+P ++W+ +G P+++ KD++ I+ G L+++ + SD
Sbjct: 344 YGPGETARLDCQV-QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVT 402
Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWR 257
C N G + A + V++ P+ + N +A C+A G PVP+V+W
Sbjct: 403 QCEARNRHGLLLAN-AYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 461
Query: 258 KDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
+DG L R+ + TL IR + A D G Y C+A N A L V++
Sbjct: 462 DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 521
Query: 316 VKPRDQVVALGRTVTFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 373
PR + G VTF C+A+ +P QP+I WR +G Q S ++ + + G
Sbjct: 522 QGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFI-EDGR 575
Query: 374 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 433
L I ++ SD G Y C + ++A L V V GPV + V D
Sbjct: 576 LVIHSLDYSDQGNYSCVASTELDVVESRAQLLV----------VGSPGPVPRLVLSDLHL 625
Query: 434 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ-IRYAKLGDTGRYTCIASTPS 492
+ S P + D + E + K+ T + +P
Sbjct: 626 LTQSQVRVSWSPA---EDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPY 682
Query: 493 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS-----RNTVTLSWQPN-- 545
T+ + ++G P +P ++ + P A + DV + ++W+P
Sbjct: 683 VHYTFRV-TAINKYG-PGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 740
Query: 546 LNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD 605
++ A Y ++ + WQ + V + Y V+A N+ G
Sbjct: 741 MDWNAPQVQYRVQWRPQGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGP 798
Query: 606 PSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT---VDQQS 662
Q++ G D+ Q A+ L +L+SS++ V W + Q
Sbjct: 799 EPQVTIGYS---------GEDYPQ-------AIPELEGIEILNSSAVLVKWRPVDLAQVK 842
Query: 663 QYIQGYKILYRPSGANHGESDWLVFE--VRTPAKN-SVVIPDLRKGVNYEIKARPFFNEF 719
+++GY + Y G+ S + + V PA SV++ LR +Y ++ + F
Sbjct: 843 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902
Query: 720 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDTQNGMVQEYKVW 777
G SE F+ T E P P + + T++L+ WQPP G V Y
Sbjct: 903 SGPASEFTFS-TPEGVPGHPE---ALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPL 958
Query: 778 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 822
G + + N D + + L P +RY ++ A+T G G
Sbjct: 959 DEGGKGQLSFNLR-DPELRTHNLTDLSPHLRYRFQLQATTKEGPG 1002
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 203 bits (517), Expect = 1e-51
Identities = 220/854 (25%), Positives = 352/854 (41%), Gaps = 92/854 (10%)
Query: 21 RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR 80
RL E P E + V +GE L C P ++ + + +D+ +
Sbjct: 129 RLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVT-- 186
Query: 81 MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------- 132
+ +G+L+F ++ + + Y+C A + +++ + +
Sbjct: 187 -MGQNGNLYFANVL----TSDNHSDYICHAHFPGTRTIIQKEPIDLRVKATNSMIDRKPR 241
Query: 133 --FRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK--LM 187
F N S +VA+ G+P V+EC G P PTI W + P+ +R+T + L
Sbjct: 242 LLFPTNSSSHLVALQGQPLVLECIA-EGFPTPTIKWLRPSGPMPA--DRVTYQNHNKTLQ 298
Query: 188 ITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
+ + D G+Y C+ N +G +TV P ++ +P + ++A C+ +
Sbjct: 299 LLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGPGETARLDCQVQ 357
Query: 248 GDPVPTVRWRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASA 304
G P P V WR + EL K + L + V D C A N G A+A
Sbjct: 358 GRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEARNRHGLLLANA 417
Query: 305 TLTVQEPPHFVVKPRDQ--VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS 362
+ V + P ++ +Q + G T C+A G P P++ W E +L
Sbjct: 418 YIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGTTVL-------Q 470
Query: 363 SSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 422
RF G L I ++Q +D G Y C N ++ A L+V D I QGP
Sbjct: 471 DERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ------ITQGP 524
Query: 423 VNQTVAVDGTFVLSCVATGSPV--PTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLG 479
+ +C A+ P P+I WR DG L DS +E+G L I
Sbjct: 525 RSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIEDGRLVIHSLDYS 584
Query: 480 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVT 539
D G Y+C+AST A + V V P P P L+ S ++ ++++ V
Sbjct: 585 DQGNYSCVASTELDVVESRAQLLV------VGSPGPV-PRLVLS-----DLHLLTQSQVR 632
Query: 540 LSWQPNLNSGATPTSYIIE-AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAA 598
+SW P + A Y IE + W ++ + +TS L P Y F V A
Sbjct: 633 VSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPYVHYTFRVTAI 692
Query: 599 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 658
N YG +PS +S+ V T + P VD K E N V+ + + W +
Sbjct: 693 NKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVI----------TWKPLRW-M 741
Query: 659 DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNE 718
D + +Q Y++ +RP G W V P +V+ + V YEIK + ++
Sbjct: 742 DWNAPQVQ-YRVQWRPQGT---RGPWQEQIVSDP---FLVVSNTSTFVPYEIKVQAVNSQ 794
Query: 719 FQGADSEIKFAKTLEEAPSAPP--QGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 776
+G + ++ + E+ P A P +G+ + N +A+LV W+P G ++ Y V
Sbjct: 795 GKGPEPQVTIGYSGEDYPQAIPELEGIEIL----NSSAVLVKWRPVDLAQVKGHLRGYNV 850
Query: 777 --WCLGNETRY---HINK---TVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQ 828
W G++ ++ HI+K V +T SV++ L P Y +EV A G GSG SE
Sbjct: 851 TYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRGSGPASE-- 908
Query: 829 FIQLDAHGNPVSPE 842
F G P PE
Sbjct: 909 FTFSTPEGVPGHPE 922
Score = 191 bits (486), Expect = 4e-48
Identities = 148/509 (29%), Positives = 227/509 (44%), Gaps = 35/509 (6%)
Query: 28 PPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 86
PP I E P L+V + +L C+A G+P W + G + ++ + SG
Sbjct: 34 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93
Query: 87 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
S F + + ++ +G+Y C A N LG A+SH L ++ V V GE
Sbjct: 94 S-FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 152
Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDA-GKYVC--- 201
V+ C PP I W +DER+T+ + G L SD Y+C
Sbjct: 153 SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 212
Query: 202 -VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF----------KCEARGDP 250
GT + ++E +L V S + R L + S+ +C A G P
Sbjct: 213 FPGTRTIIQKEP--IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 270
Query: 251 VPTVRWRKDDGELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 309
PT++W + G +P R ++ + TL++ KV D G Y C+AEN +G A + +TV+
Sbjct: 271 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 330
Query: 310 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 369
P+++ KP+ + G T C+ G PQP + WR G + ++ +
Sbjct: 331 AAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPVEELAKDQKYRI- 384
Query: 370 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT-VA 428
Q G L ++NVQ SD C+ N G ++ AY+ V + P ++ NQT +A
Sbjct: 385 QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL----PAKILTAD--NQTYMA 438
Query: 429 VDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 487
V G T L C A G+PVP++ W + QD R NG L IR + DTGRY C+
Sbjct: 439 VQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCL 498
Query: 488 ASTPSGEATWSAYIEVQEFGVPVQPPRPT 516
A+ T A ++V++ Q PR T
Sbjct: 499 AANDQNNVTIMANLKVKDATQITQGPRST 527
Score = 174 bits (441), Expect = 6e-43
Identities = 201/825 (24%), Positives = 338/825 (40%), Gaps = 87/825 (10%)
Query: 26 DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 82
D PR++ S L+ +G+P L C AEG PTPTI+W + + D+ ++H
Sbjct: 237 DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKT 296
Query: 83 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVM 141
L L++ D+G Y C+A N LG A ++ ++E A + P +
Sbjct: 297 LQ-----LLKV-----GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY---WLHKPQSHL 343
Query: 142 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD--KDERITIRGGKLMITYTRKSDAGKY 199
GE A ++CQ +G P+P ++W+ +G P+++ KD++ I+ G L+++ + SD
Sbjct: 344 YGPGETARLDCQV-QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVT 402
Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWR 257
C N G + A + V++ P+ + N +A C+A G PVP+V+W
Sbjct: 403 QCEARNRHGLLLAN-AYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 461
Query: 258 KDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
+DG L R+ + TL IR + A D G Y C+A N A L V++
Sbjct: 462 DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 521
Query: 316 VKPRDQVVALGRTVTFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 373
PR + G VTF C+A+ +P QP+I WR +G Q S ++ + + G
Sbjct: 522 QGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFI-EDGR 575
Query: 374 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 433
L I ++ SD G Y C + ++A L V V GPV + V D
Sbjct: 576 LVIHSLDYSDQGNYSCVASTELDVVESRAQLLV----------VGSPGPVPRLVLSDLHL 625
Query: 434 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ-IRYAKLGDTGRYTCIASTPS 492
+ S P + D + E + K+ T + +P
Sbjct: 626 LTQSQVRVSWSPA---EDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPY 682
Query: 493 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS-----RNTVTLSWQPN-- 545
T+ + ++G P +P ++ + P A + DV + ++W+P
Sbjct: 683 VHYTFRV-TAINKYG-PGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 740
Query: 546 LNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD 605
++ A Y ++ + WQ + V + Y V+A N+ G
Sbjct: 741 MDWNAPQVQYRVQWRPQGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGP 798
Query: 606 PSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT---VDQQS 662
Q++ G D+ Q A+ L +L+SS++ V W + Q
Sbjct: 799 EPQVTIGYS---------GEDYPQ-------AIPELEGIEILNSSAVLVKWRPVDLAQVK 842
Query: 663 QYIQGYKILYRPSGANHGESDWLVFE--VRTPAKN-SVVIPDLRKGVNYEIKARPFFNEF 719
+++GY + Y G+ S + + V PA SV++ LR +Y ++ + F
Sbjct: 843 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902
Query: 720 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDTQNGMVQEYKVW 777
G SE F+ T E P P + + T++L+ WQPP G V Y
Sbjct: 903 SGPASEFTFS-TPEGVPGHPE---ALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPL 958
Query: 778 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 822
G + + N D + + L P +RY ++ A+T G G
Sbjct: 959 DEGGKGQLSFNLR-DPELRTHNLTDLSPHLRYRFQLQATTKEGPG 1002
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 203 bits (516), Expect = 1e-51
Identities = 220/857 (25%), Positives = 349/857 (40%), Gaps = 89/857 (10%)
Query: 17 CSGSRLRQEDFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDK 73
C G L + P ++ PS+ I S+ + TL+C+A G P+P W G +D
Sbjct: 16 CLGGELLLQG--PVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNG----SDI 69
Query: 74 DDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDF 133
D HR L G+L +V D G Y C A N LG VS A L+ A L +
Sbjct: 70 DMSMEHRYKLNGGNL----VVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFK 125
Query: 134 RQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL---DDKDERITIRGGKLMITY 190
+ S V V G+ V+ C PP E + +W + P +D ++ G L I+
Sbjct: 126 TKMRSTVSVREGQGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISK 185
Query: 191 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSA 240
SD G Y CV T+MV + ++ R V+ P L +
Sbjct: 186 VEPSDVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTV 245
Query: 241 EFKCEARGDPVPTVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGK 299
+ +C A G+P+P + WR+ DG S+ ++R L+I D GSY C+AEN GK
Sbjct: 246 KLECFALGNPIPQINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGK 305
Query: 300 AEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 359
A LT PH+V +D +A+ ++ ++C A+G P+P+ W + G+ +L
Sbjct: 306 NVARGRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVL----- 360
Query: 360 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 419
R + + G LTI+N+ +D G + C N G + + A L+V P
Sbjct: 361 ---EERTQI-ENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVV-----ASAPDFS 411
Query: 420 QGPVNQTVAVD-GTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477
+ P+ + V V G+ V L C SP W+K V V + RI L +G L+I
Sbjct: 412 KNPMKKLVQVQVGSLVSLDCKPRASPRALSSWKKGDVSVQ-EHERISLLNDGGLKIANVT 470
Query: 478 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 537
D G YTC+A G+A + ++ V T+P I APS +V+
Sbjct: 471 KADAGTYTCMAENQFGKANGTTHLVV------------TEPTRITLAPSNMDVSVGESVI 518
Query: 538 VTLSWQPNLNSGATPTSYIIEAFS--HASGSSWQTVAENVKTETSAIK-GLKPNAIYLFL 594
+ Q + T Y A + GS ++ V + + LK + Y+ +
Sbjct: 519 LPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCM 578
Query: 595 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 654
V+ G+ S +D ++ S G E+ + L + S +
Sbjct: 579 VQT----GVDSVSSAADL-----IVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVI 629
Query: 655 HWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARP 714
+++ ++ + G++ + V EV ++ + +L V YE +
Sbjct: 630 SYSIQARTPFSVGWQTV------------TTVPEVIDGKTHTATVVELNPWVEYEFRV-V 676
Query: 715 FFNEFQGADSEIKFAK--TLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQ 772
N+ G + + K T E P PP V+ G+ + ++++W P PE+ QNG
Sbjct: 677 ASNKIGGGEPSLPSEKVRTEEAVPEVPPS--EVNGGGGSRSELVITWDPVPEELQNGEGF 734
Query: 773 EYKVWC--LGNETRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQF 829
Y V LG T + + D + +VP Y V+V G G S P
Sbjct: 735 GYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFS-PVT 793
Query: 830 IQLDAHGNPVSPEDQVS 846
A P QVS
Sbjct: 794 TVFSAEEEPTVAPSQVS 810
Score = 201 bits (511), Expect = 5e-51
Identities = 199/761 (26%), Positives = 317/761 (41%), Gaps = 102/761 (13%)
Query: 102 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFR---------QNPSDVMVAVGEPAVMEC 152
D G Y CV + + A + + + D Q P + A G +EC
Sbjct: 190 DVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLEC 249
Query: 153 QPPRGHPEPTISWKK-DGSPLDDKDERITIR--GGKLMITYTRKSDAGKYVCVGTNMVGE 209
G+P P I+W++ DG P K I +R G L I ++ DAG Y C+ N G+
Sbjct: 250 FA-LGNPIPQINWRRSDGLPFSSK---IKLRKFSGVLEIPNFQQEDAGSYECIAENSRGK 305
Query: 210 RESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE 269
+ LT +P +V+ ++ + V+DS ++C A G P P+ RW K+ L
Sbjct: 306 NVAR-GRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERT 364
Query: 270 IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL-TVQEPPHFVVKPRDQVVAL--G 326
++ L I ++ D G + C+AEN G +SA L V P F P ++V + G
Sbjct: 365 QIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVG 424
Query: 327 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 386
V+ C+ +P+ W++ G ++ Q R S+ G L I NV ++D G
Sbjct: 425 SLVSLDCKPRASPRALSSWKK-GDVSV-------QEHERISLLNDGGLKIANVTKADAGT 476
Query: 387 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 446
Y C N G +L VT+ P I P N V+V + +L C P+
Sbjct: 477 YTCMAENQFGKANGTTHLVVTE------PTRITLAPSNMDVSVGESVILPCQVQHDPLLD 530
Query: 447 IL--WRKDGVLVSTQDS-----RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 499
I+ W +G L + ++ +G L IR +L +G+Y C+ T + +A
Sbjct: 531 IIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAA 590
Query: 500 YIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEA 559
+ V+ P P +V +++ T LSW+ ++ + SY I+A
Sbjct: 591 DLIVRGS---------------PGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQA 635
Query: 560 FSHASGSSWQTVAE-----NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 614
+ S WQTV + KT T+ + L P Y F V A+N G +PS S+ V+
Sbjct: 636 RTPFS-VGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVR 694
Query: 615 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQ-----GYK 669
T++ +P V +V G S S + + W D + +Q GY
Sbjct: 695 TEEAVPE---VPPSEVNGGGG------------SRSELVITW--DPVPEELQNGEGFGYV 737
Query: 670 ILYRPSGANHGESDWLVFEVRTP------AKNSVVIPDLRKGVNYEIKARPFFNEFQGAD 723
+ +RP G + W+ V +P +N ++P YE+K + N+ +G
Sbjct: 738 VAFRPLGV----TTWIQTVVTSPDTPRYVFRNESIVP----YSPYEVKVGVYNNKGEGPF 789
Query: 724 SEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCLGN 781
S + + EE P+ P VS N + + I VSW P NG + Y+V W G
Sbjct: 790 SPVTTVFSAEEEPTVAPS--QVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGG 847
Query: 782 ETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 822
+ V G+ S + L + Y V A AG+G
Sbjct: 848 KEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAG 888
Score = 169 bits (427), Expect = 3e-41
Identities = 212/850 (24%), Positives = 326/850 (38%), Gaps = 109/850 (12%)
Query: 26 DFPPRI-VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
++ P+I V+ P L +KG L C A G P P I W + LP
Sbjct: 224 EYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQINWRRSDG---------------LP 268
Query: 85 SGSLFFLRIVHGRKSRP-----DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD 139
S LR G P D G Y C+A N G+ V+ A + + Q D
Sbjct: 269 FSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYA--KPHWVQLIKD 326
Query: 140 VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKY 199
V +AV + EC+ G P+P+ W K+G+ L +ER I G L I+ +D+G +
Sbjct: 327 VEIAVEDSLYWECRAS-GKPKPSYRWLKNGAALV-LEERTQIENGALTISNLSVTDSGMF 384
Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSN--LAVTVDDSAEFKCEARGDPVPTVRWR 257
C+ N G S V P F K P + V V C+ R P W+
Sbjct: 385 QCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVGSLVSLDCKPRASPRALSSWK 444
Query: 258 KDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV 316
K D + + R + +D LKI VT D G+YTC+AEN GKA + L V EP +
Sbjct: 445 KGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCMAENQFGKANGTTHLVVTEPTRITL 504
Query: 317 KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 376
P + V++G +V C+ +P I + + L + + S +GDL I
Sbjct: 505 APSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMI 564
Query: 377 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV------- 429
N+Q G Y+C S+ + A L V + PP ++ + T A
Sbjct: 565 RNIQLKHSGKYVCMVQTGVDSVSSAADLIVRG--SPGPPENVKVDEITDTTAQLSWKEGK 622
Query: 430 -DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 488
+ + V+S ++ W+ + D G T T +
Sbjct: 623 DNHSPVISYSIQARTPFSVGWQTVTTVPEVID------------------GKTHTATVVE 664
Query: 489 STPSGEATW----SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 544
P E + S I E +P + R T+ + PS+ SR+ + ++W P
Sbjct: 665 LNPWVEYEFRVVASNKIGGGEPSLPSEKVR-TEEAVPEVPPSEVNGGGGSRSELVITWDP 723
Query: 545 ---NLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTETSAIKG--LKPNAIYLFLVRAA 598
L +G Y++ AF ++W QTV + T + + P + Y V
Sbjct: 724 VPEELQNGEG-FGYVV-AFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVY 781
Query: 599 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 658
N G S ++ ++ PT V QV + LSSS IEV W
Sbjct: 782 NNKGEGPFSPVTTVFSAEEE-PT---VAPSQV------------SANSLSSSEIEVSWNT 825
Query: 659 ---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPF 715
+ ++ GY++ Y G S + + S + L+ + Y R +
Sbjct: 826 IPWKLSNGHLLGYEVRYWNGGGKEESSSKMKVAGN---ETSARLRGLKSNLAYYTAVRAY 882
Query: 716 FNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYK 775
+ G S T + PS PP V + D T +L++W+ V YK
Sbjct: 883 NSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATD---TKVLLNWEQVKAMENESEVTGYK 939
Query: 776 VW----CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE----P 827
V+ N + NKT + +V+P Y +EV A+T G G SE P
Sbjct: 940 VFYRTSSQNNVQVLNTNKT----SAELVLPIKED---YIIEVKATTDGGDGTSSEQIRIP 992
Query: 828 QFIQLDAHGN 837
+ +DA G+
Sbjct: 993 RITSMDARGS 1002
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 203 bits (516), Expect = 1e-51
Identities = 213/822 (25%), Positives = 326/822 (39%), Gaps = 89/822 (10%)
Query: 40 VSKGEPATLNC-KAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 98
VS+G A LN P P + W++ G ++ P + + L L
Sbjct: 202 VSQGRAAILNLLPITSYPRPQVTWFREGHKII-----PSNRIAITLENQLVILAT----- 251
Query: 99 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVM-------VAVGEPA 148
+ D G Y A N + + ++I RD P+ V+ VA
Sbjct: 252 TTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSET 311
Query: 149 VMEC-QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT--N 205
+EC R + +++WK++G + G +L I+ +D G YVC
Sbjct: 312 TLECIASARPVEDLSVTWKRNGVRITSGLHSF---GRRLTISNPTSADTGPYVCEAALPG 368
Query: 206 MVGERESEVAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDD---G 261
E A L ++E P F P S ++ V+++ + C+A G P+PT++W KD
Sbjct: 369 SAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISIS 428
Query: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE-PPHFVVKPRD 320
L RY++ L+I+K+ D G + C A N G+ + L V P F +P D
Sbjct: 429 RLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVD 488
Query: 321 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
V G T +CE +G P+PAI W+RE S + P RF + ++G L I V
Sbjct: 489 TTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIP----RFMLLESGGLQIAPVF 544
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 440
D G Y C N GS+ A L V + + PP + V T L C AT
Sbjct: 545 IQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPE------DHVVIKGTTATLHCGAT 598
Query: 441 GSPVPTI--LWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 497
P ++ +W+KD V L + SRI ++G L I GD G Y+C + G +
Sbjct: 599 HDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSR 658
Query: 498 SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII 557
A +EV E P P + +P+ + V LSW + + YI+
Sbjct: 659 MARLEVIEL--------PHSPQNLLVSPNSSH-----SHAVVLSWVRPFDGNSPILYYIV 705
Query: 558 EAFSHASGSSWQTVAENVKTETSAI--KGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 615
E + S W+ NV E + + GL P Y F V A N G S + +
Sbjct: 706 ELSEN--NSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLML 763
Query: 616 QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQY---IQGYKILY 672
+ P++ + R ++ SI V W ++++ ++GY + Y
Sbjct: 764 PEEPPSAPPKNIVASGR---------------TNQSIMVQWQPPPETEHNGVLRGYILRY 808
Query: 673 RPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTL 732
R +G ++ + +P N ++ DL YEI+ + G S TL
Sbjct: 809 RLAGL---PGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTL 865
Query: 733 EEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVD 792
+ P+APPQ V N T I W PPP+ NG+ Q YK+ + +
Sbjct: 866 QGVPTAPPQNVQTEAV--NSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTI 923
Query: 793 GSTFSVV----IPFLVPGIRYSVEVAASTGAGSGVKSEPQFI 830
F V I L Y V T G G S PQ +
Sbjct: 924 APDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLV 965
Score = 196 bits (499), Expect = 1e-49
Identities = 209/850 (24%), Positives = 330/850 (38%), Gaps = 96/850 (11%)
Query: 22 LRQEDFPPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR 80
L Q+D P P I +G L C AEG +W + + T + ++
Sbjct: 97 LAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSE---YK 153
Query: 81 MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 140
++PS + D G Y CV RN +G + + ++VA + F
Sbjct: 154 YIIPS------------LQKLDAGFYRCVVRNRMGALLQRKSEVQVAYM-GSFMDTDQRK 200
Query: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYV 200
V+ G A++ P +P P ++W ++G + + +L+I T SDAG Y
Sbjct: 201 TVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYY 260
Query: 201 CVGTNMVG--ERESEVAELTVLE--------RPSFVKRPSNLAVTVDDS-AEFKCEARGD 249
N + S L++ P+ V P N +V S +C A
Sbjct: 261 VQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASAR 320
Query: 250 PVP--TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAE---NMVGKAEASA 304
PV +V W+++ + + L I T+ D G Y C A + A A+A
Sbjct: 321 PVEDLSVTWKRNGVRITSGLHSF--GRRLTISNPTSADTGPYVCEAALPGSAFEPARATA 378
Query: 305 TLTVQEPPHFVVKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 363
L + EPP+F +P ++ A + TV C+A G P P + W ++ + Q P
Sbjct: 379 FLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAIS--ISRLQNP--- 433
Query: 364 SRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 423
R+ V +G L I ++ D G + C N G I T YL+VT++ PV Q PV
Sbjct: 434 -RYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIA-----PVFTQRPV 487
Query: 424 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQ---LENGVLQIRYAKLGD 480
+ TV T +L C +G+P P I W+++ ++++ RI + LE+G LQI + D
Sbjct: 488 DTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD 547
Query: 481 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 540
G YTC A+ G SA + V V PP + V
Sbjct: 548 AGNYTCYAANTEGSLNASATLTVWNRTSIVHPPED--------------------HVVIK 587
Query: 541 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA 600
L+ GAT + + W+ +NV L P++ +V +
Sbjct: 588 GTTATLHCGATHDPRVSLRY------VWK--KDNV--------ALTPSSTSRIVVEKDGS 631
Query: 601 YGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ 660
IS S + S+G + ++ R + H ++S +S H V
Sbjct: 632 LLIS--QTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLS 689
Query: 661 QSQYIQGYK-ILYRPSGANHGESDWLVFEVRT-PAKNSVVIPDLRKGVNYEIKARPFFNE 718
+ G ILY + S W V P V + L Y+ +
Sbjct: 690 WVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEV 749
Query: 719 FQGA-DSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY--K 775
+G +E EE PSAPP+ + S +I+V WQPPPE NG+++ Y +
Sbjct: 750 GRGQYSAETSRLMLPEEPPSAPPKNIVASGR--TNQSIMVQWQPPPETEHNGVLRGYILR 807
Query: 776 VWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAH 835
G Y ++ L+ +Y ++VAA GAG GV S +
Sbjct: 808 YRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSR-AVTEYTLQ 866
Query: 836 GNPVSPEDQV 845
G P +P V
Sbjct: 867 GVPTAPPQNV 876
Score = 93.6 bits (231), Expect = 1e-18
Identities = 95/343 (27%), Positives = 145/343 (42%), Gaps = 47/343 (13%)
Query: 518 PNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSS--WQTVAENV 575
P +P APS ++++S + TL ++P + + + +I+E A G W T+ E
Sbjct: 1066 PPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEE 1125
Query: 576 K---TETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT----QDVLPTSQGVDHK 628
+ I L P Y F ++ N G S S S ++T DV PTS V
Sbjct: 1126 NEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTV--- 1182
Query: 629 QVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQY-----IQGYKILYRPSGANHGESD 683
S +S+ + W SQY GY+I Y S +S
Sbjct: 1183 ----------------RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDL---QSS 1223
Query: 684 WLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGV 743
+ V + I +L + + YE++ + F G SE+ +T E PSA P+ V
Sbjct: 1224 AVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENV 1283
Query: 744 TVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC----LGNETRYHINKTVDGSTFSVV 799
S + T IL++W PE QNG++ YK+ L E R HI + T S +
Sbjct: 1284 --SAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVR--GNHTQSAL 1339
Query: 800 IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL---DAHGNPV 839
+ L + Y ++V A T G+GV S P ++ DA G PV
Sbjct: 1340 LAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPV 1382
Score = 92.4 bits (228), Expect = 3e-18
Identities = 195/874 (22%), Positives = 298/874 (34%), Gaps = 164/874 (18%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDD-PRSHRMLLPSGS 87
P + P D V+ G A L C+ G P P I W + + + PR MLL SG
Sbjct: 480 PVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRF--MLLESGG 537
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL-RDDFRQNPSDVMVAVGE 146
L + D G Y C A N G S NAS + + R P D +V G
Sbjct: 538 LQIAPVFI-----QDAGNYTCYAANTEG---SLNASATLTVWNRTSIVHPPEDHVVIKGT 589
Query: 147 PAVMECQPPRGHPEPTIS----WKKDGSPLDDKD-ERITI-RGGKLMITYTRKSDAGKYV 200
A + C +P +S WKKD L RI + + G L+I+ T D G Y
Sbjct: 590 TATLHCGATH---DPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYS 646
Query: 201 CVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKD 259
C + G +S +A L V+E P P NL V+ + S + W R
Sbjct: 647 CEIVSE-GGNDSRMARLEVIELPH---SPQNLLVSPNSSHSHAV--------VLSWVRPF 694
Query: 260 DGELPKSRYEIRDDHTLKIRKVTAGDMG-----------------SYTCVAENMVGK--- 299
DG P Y + KV ++G + A N VG+
Sbjct: 695 DGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQY 754
Query: 300 -AEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQ 358
AE S + +EPP P +VA GRT +Q+++ +Q
Sbjct: 755 SAETSRLMLPEEPPS---APPKNIVASGRT---------------------NQSIMVQWQ 790
Query: 359 PPQSSSRFSVSQ-----------TGDLTITNVQRSDVGYYICQTL-------------NV 394
PP + V + G+ N+ +V Y + L N
Sbjct: 791 PPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNG 850
Query: 395 AG-SIITKAYLEVT-DVIADRPPPVIRQGPVNQTVAV-----DGTFVLSCVATGSPVPTI 447
AG + ++A E T + PP ++ VN T ++ + G + +
Sbjct: 851 AGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFINGINQGYKL--L 908
Query: 448 LWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFG 507
W D T + + + + + + ++T + V F
Sbjct: 909 AWPADAPEAVT----VVTIAPDFHGVHHGHITNLKKFTAY------------FTSVLCFT 952
Query: 508 VPVQPPRPTDPNLIPSAPSKP------EVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFS 561
P P P+ P L+ + KP T++ ++ +SWQ L T Y I
Sbjct: 953 TPGDGP-PSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGIITGYQISWEV 1011
Query: 562 HASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPT 621
+ S T N T I+GL Y V A A G ++ + V P
Sbjct: 1012 YGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVG---TGLVTSSTISSGVPPD 1068
Query: 622 SQGVDHKQVQRELG--NAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANH 679
G V + +A L P +SI W V+ Q GA
Sbjct: 1069 LPGAPSNLVISNISPRSATLQF-RPGYDGKTSIS-RWIVEGQ-------------VGAIG 1113
Query: 680 GESDWLVF--EVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADS-EIKFAKTLEEAP 736
E +W+ E P + IP+L +Y + + S + +TL+ P
Sbjct: 1114 DEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPP 1173
Query: 737 SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQ----EYKVWCLGNETRYHINKTVD 792
P VTV + T++ + W P P+ NG + K W ++ D
Sbjct: 1174 DVAPTSVTV--RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSD 1231
Query: 793 GSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 826
I L + Y +++ A G+G SE
Sbjct: 1232 RLEREFTIEELEEWMEYELQMQAFNAVGAGPWSE 1265
Score = 75.9 bits (185), Expect = 3e-13
Identities = 86/342 (25%), Positives = 139/342 (40%), Gaps = 51/342 (14%)
Query: 513 PRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVA 572
P P L+P A +V+ ++ L W P + GA+P Y WQT +
Sbjct: 1477 PAPPRELLVPQA-------EVTARSLRLQWVPG-SDGASPIRYFTMQVRELPRGEWQTYS 1528
Query: 573 ENVKTETSA--IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 630
++ E +A + L+P Y ++A N G SD S ++ V T +P
Sbjct: 1529 SSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPG--------- 1579
Query: 631 QRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQY---IQGYKILYRP------SG----- 676
E +V + T ++SS+ + W + +QGY+I YR SG
Sbjct: 1580 --EPPGSV----SATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKT 1633
Query: 677 -----ANHGE-SDWLVFEVRTPAKNSVV--IPDLRKGVNYEIKARPFFNEFQGADSEIKF 728
A H E + F+ + S + + L+K YE+ + + S
Sbjct: 1634 LKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVE 1693
Query: 729 AKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCLGNETRYH 786
E AP+ PQ V V+ + + V+W PPP ++QNG +Q YK+ W ++
Sbjct: 1694 VFVGEAAPAMAPQNVQVTPL--TASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETE 1751
Query: 787 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQ 828
K + V + L +Y V ++A AG G KS+PQ
Sbjct: 1752 KMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQ 1793
Score = 57.4 bits (137), Expect = 1e-07
Identities = 84/332 (25%), Positives = 138/332 (41%), Gaps = 37/332 (11%)
Query: 524 APSKPEVTDVSRNTVTLSWQP----NLNSGATPTSYIIEAFSHASGSSW--QTVAENVKT 577
AP+ V S ++ L W P N Y I+ + SS Q V++ ++
Sbjct: 1176 APTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLER 1235
Query: 578 ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNA 637
E + I+ L+ Y ++A NA G S++ +T++ +P++ + V E
Sbjct: 1236 EFT-IEELEEWMEYELQMQAFNAVGAGPWSEVVRG-RTRESVPSAAP---ENVSAE---- 1286
Query: 638 VLHLHNPTVLSSSSIEVHWT-VDQQSQ--YIQGYKILYRPSGANHGESDWLVFEVRTPAK 694
+SS+ I + WT V +Q Q I GYKIL+R + +V R
Sbjct: 1287 --------AVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIV---RGNHT 1335
Query: 695 NSVVIPDLRKGVNYEIKARPFFNEFQGADSE-IKFAKTLEEAPSAPPQGVTVSKNDGNGT 753
S ++ LRK V YE++ F G S + +T ++AP P V + + T
Sbjct: 1336 QSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPP---VRLVFPEVRLT 1392
Query: 754 AILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVD-GSTF-SVVIPFLVPGIRYSV 811
++ + WQPP E NG++ Y++ + H TV+ G+T L P Y
Sbjct: 1393 SVRIVWQPPEE--PNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIF 1450
Query: 812 EVAASTGAGSGVKSEPQFIQLDAHGNPVSPED 843
++A T G G E I + P P +
Sbjct: 1451 RLSAKTRQGWGEPLEATVITTEKRERPAPPRE 1482
Score = 47.8 bits (112), Expect = 9e-05
Identities = 88/403 (21%), Positives = 152/403 (37%), Gaps = 54/403 (13%)
Query: 524 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENV---KTETS 580
AP +VT ++ + + ++W P + + + S +T V
Sbjct: 1704 APQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVV 1763
Query: 581 AIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLH 640
+K L + YL + A NA G S DP QG H+
Sbjct: 1764 RLKNLTSHTKYLVSISAFNAAGDGPKS---DP---------QQGRTHQAAPGAPSFLAF- 1810
Query: 641 LHNPTVLSSSSIEVHWTVDQQSQYI-QGYKILYRPSGANHGESDWLVFEVRTPAKNSVVI 699
+ ++S+++ V W + I QGY+++Y P G S + EVR + + +
Sbjct: 1811 ----SEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKV 1866
Query: 700 PDLRKGVNY--EIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILV 757
DL KGV Y ++AR G + + E P+ V V+K + + + +
Sbjct: 1867 RDLTKGVTYFFRVQARTI---TYGPELQANITAGPAEGSPGSPRDVLVTK---SASELTL 1920
Query: 758 SWQP--PPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAA 815
W + G V E + G + + +++++ + L G+ Y V A
Sbjct: 1921 QWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVA 1980
Query: 816 STGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAF--IAGIGAACWIILM 873
AG +G P +P VS AQ + ++ F + + + I+L+
Sbjct: 1981 VNEAG--------------YGEPSNPSTAVS-AQVEAPFYEEWWFLLVMALSSLIVILLV 2025
Query: 874 VFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEA 916
VF++ L+ KK ST GI T +VT GG A
Sbjct: 2026 VFALVLHGQNKKYKN-CSTGKGIS-----TMEESVTLDNGGFA 2062
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 200 bits (508), Expect = 1e-50
Identities = 185/721 (25%), Positives = 299/721 (41%), Gaps = 82/721 (11%)
Query: 133 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGGKLMI 188
F PSD + G +++C P I WKKDG L D++ ++++ G L+I
Sbjct: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS--NGSLLI 99
Query: 189 -----TYTRKSDAGKYVCVGT-NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 242
+ K D G Y C + G S A++ V F+ + ++ + D+
Sbjct: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
Query: 243 KCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
KCE G+P+PT+ W+K+ +L SR + L+I ++ GD+G Y C A N
Sbjct: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
Query: 299 KAEAS-ATLTVQEPP------HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 351
+ A + + P +F+ +P + V G+ +C +G P P+ W R G +
Sbjct: 220 SRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GEE 278
Query: 352 NLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 411
+ S ++S+ +L I+NV D G Y C +I A L V
Sbjct: 279 VIQL------RSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL---- 328
Query: 412 DRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVL 471
PP P N C +G PVPT+ W K+G +V D + + L
Sbjct: 329 --VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSD-YFQIVGGSNL 385
Query: 472 QIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVT 531
+I D G Y C+A +G A SA + V + +P +++PSAP
Sbjct: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP-------SSSVLPSAPRDVVPV 438
Query: 532 DVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET--SAIKGLKPNA 589
VS V LSW+P + ++ + F G + + + + + LKP A
Sbjct: 439 LVSSRFVRLSWRPPAEAKGNIQTFTV--FFSREGDNRERALNTTQPGSLQLTVGNLKPEA 496
Query: 590 IYLFLVRAANAYGISDPSQISDPVK--TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 647
+Y F V A N +G P + S P+K TQ L V++ Q ++L P
Sbjct: 497 MYTFRVVAYNEWG---PGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAY 553
Query: 648 SSSSIEVHWTVDQQSQYIQGYKIL---YRPSGANHGESDWLVFEVRTPAKNSVVIPDLRK 704
++ +QGY++ + E D L ++ + L+K
Sbjct: 554 ANGP-------------VQGYRLFCTEVSTGKEQNIEVDGLSYK----------LEGLKK 590
Query: 705 GVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPE 764
Y ++ + G ++ TL + PSAPPQ V++ N +I VSW PPP
Sbjct: 591 FTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEV--VNSRSIKVSWLPPPS 648
Query: 765 DTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVK 824
TQNG + YK+ TR +T++ + + L G +YS +V+A T G+G
Sbjct: 649 GTQNGFITGYKI-RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPP 707
Query: 825 S 825
S
Sbjct: 708 S 708
Score = 195 bits (495), Expect = 3e-49
Identities = 214/834 (25%), Positives = 319/834 (38%), Gaps = 108/834 (12%)
Query: 30 RIVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
R + PSD + +G L+C AE R P I+W K G + D+ + L +GSL
Sbjct: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97
Query: 89 FFLRIVHGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVA-ILRDDFRQNPSDVMVAVGE 146
I+H R +PDEG+Y C A G +S A + VA LR F V +G+
Sbjct: 98 LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155
Query: 147 PAVMECQPPRGHPEPTISWKK---DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 203
+++C+ G P PTI W+K D +P+ + + G L I+ + D G Y C
Sbjct: 156 TVLLKCE-VIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214
Query: 204 TNMVGERESEVAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
N R AE+ +L P F++RPSN+ A +C G P P+ W
Sbjct: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
Query: 258 KDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 315
+ + +L +Y + L I VT D G YTCV ASA LTV PP F+
Sbjct: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL 334
Query: 316 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 375
P + + F+C +G P P + W + G + Y F + +L
Sbjct: 335 NHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDY--------FQIVGGSNLR 386
Query: 376 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 435
I V +SD G+Y C N AG+ T A L V P P I V + D VL
Sbjct: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIV-------PKPAIPSSSVLPSAPRDVVPVL 439
Query: 436 ------------SCVATGS-PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTG 482
A G+ T+ + ++G ++ + + G LQ+ L
Sbjct: 440 VSSRFVRLSWRPPAEAKGNIQTFTVFFSREG---DNRERALNTTQPGSLQLTVGNLKPEA 496
Query: 483 RYT--CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-IPSAPSKPEVTDVSRNTVT 539
YT +A G S I+V T P L +P + S ++
Sbjct: 497 MYTFRVVAYNEWGPGESSQPIKV-----------ATQPELQVPGPVENLQAVSTSPTSIL 545
Query: 540 LSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSAIKGLKPNAIYLFLVRA 597
++W+P + Y + ++G +N++ + + ++GLK Y A
Sbjct: 546 ITWEPPAYANGPVQGYRLFCTEVSTGKE-----QNIEVDGLSYKLEGLKKFTEYSLRFLA 600
Query: 598 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW- 656
N YG P +D + T L + V E V++S SI+V W
Sbjct: 601 YNRYG---PGVSTDDI-TVVTLSDVPSAPPQNVSLE------------VVNSRSIKVSWL 644
Query: 657 --TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARP 714
Q+ +I GYKI +R + GE E P + L KG Y +
Sbjct: 645 PPPSGTQNGFITGYKIRHRKT-TRRGE-----METLEPNNLWYLFTGLEKGSQYSFQVSA 698
Query: 715 FFNEFQGADSEIKFAKTLE---EAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDTQNG 769
G S A+T E + P Q ++ I++SW PP P G
Sbjct: 699 MTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIVVRG 757
Query: 770 MVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 823
+ Y G + Y VD I L Y + + A AG GV
Sbjct: 758 YIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGV 806
Score = 157 bits (397), Expect = 8e-38
Identities = 227/858 (26%), Positives = 329/858 (38%), Gaps = 124/858 (14%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
P R + + G+ L C+ G P PTI W K + + D R ++LPSG+
Sbjct: 139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRV--VVLPSGA 196
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDV 140
L R+ G D G+Y C ARN + A EV IL D F Q PS+V
Sbjct: 197 LQISRLQPG-----DIGIYRCSARNPASSRTGNEA--EVRILSDPGLHRQLYFLQRPSNV 249
Query: 141 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKY 199
+ G+ AV+EC G+P P+ +W + + + ++ ++ GG L+I+ D+G Y
Sbjct: 250 VAIEGKDAVLECCVS-GYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMY 308
Query: 200 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 259
CV T E S AELTVL P F+ PSNL EF+C G PVPTV W K+
Sbjct: 309 TCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKN 367
Query: 260 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP--PHFVV 316
D +P ++I L+I V D G Y CVAEN G A+ SA L V +P P V
Sbjct: 368 GDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSV 427
Query: 317 ---KPRDQVVAL--GRTVTFQ----CEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRF 366
PRD V L R V EA GN Q +F+ REG
Sbjct: 428 LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNR----------ERAL 477
Query: 367 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ------ 420
+ +Q G L +T Y + + AY E + +P V Q
Sbjct: 478 NTTQPGSLQLTVGNLKPEAMYTFRVV---------AYNEWGPGESSQPIKVATQPELQVP 528
Query: 421 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLG 479
GPV AV T S + T P G L T+ S K+ V + Y KL
Sbjct: 529 GPVENLQAV-STSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSY-KLE 586
Query: 480 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL--IPSA-PSKPEVTDVSRN 536
++T + ++ +G V T L +PSA P + V+
Sbjct: 587 GLKKFTEYS---------LRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSR 637
Query: 537 TVTLSW--QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFL 594
++ +SW P+ T Y I +T+ N GL+ + Y F
Sbjct: 638 SIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPN--NLWYLFTGLEKGSQYSFQ 695
Query: 595 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 654
V A G PS ++ L SQ D + LH+ T + I +
Sbjct: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQP--------SSLHVRPQT----NCIIM 743
Query: 655 HWTVD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV-IPDLRKGVNYEIKA 712
WT + ++GY I Y G+ + E+ VR +K I L +Y I
Sbjct: 744 SWTPPLNPNIVVRGYIIGY-GVGSPYAET------VRVDSKQRYYSIERLESSSHYVISL 796
Query: 713 RPFFNEFQGA--------------DSEIKFAKTLEEAPSA---------PPQGVTVSKND 749
+ F N +G + + L++ P++ PP GV
Sbjct: 797 KAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALT 856
Query: 750 GNGTAILVSW--QPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGI 807
+ A+ VSW P++ + V+ Y V + + K+ D ++ S L P
Sbjct: 857 HD--AVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNT 914
Query: 808 RYSVEVAASTGAGSGVKS 825
Y V + S S
Sbjct: 915 MYEFSVMVTKNRRSSTWS 932
Score = 74.3 bits (181), Expect = 9e-13
Identities = 77/334 (23%), Positives = 136/334 (40%), Gaps = 31/334 (9%)
Query: 512 PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSW-QT 570
P D + +P PS V + N + +SW P LN YII + GS + +T
Sbjct: 716 PENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII---GYGVGSPYAET 771
Query: 571 VAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 630
V + K +I+ L+ ++ Y+ ++A N G P + + T+ + + VD+ +
Sbjct: 772 VRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVP--LYESATTRSITDPTDPVDYYPL 829
Query: 631 QRELGNAVLHLHNPTV---------LSSSSIEVHWT-----VDQQSQYIQGYKILYRPSG 676
+ +V L P + L+ ++ V W +Q++ ++ Y + +R S
Sbjct: 830 LDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSF 889
Query: 677 ANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAP 736
+ + ++ S L+ YE N S A T E AP
Sbjct: 890 SASAK-----YKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAP 944
Query: 737 SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNET---RYHINKTVDG 793
++ P+ +TV +G A++VSWQPP E NG + Y ++ ++ I +T+ G
Sbjct: 945 TSAPKDLTVITREGKPRAVIVSWQPPLE--ANGKITAYILFYTLDKNIPIDDWIMETISG 1002
Query: 794 STFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 827
+ I L Y + A G G S+P
Sbjct: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 194 bits (492), Expect = 8e-49
Identities = 206/819 (25%), Positives = 321/819 (39%), Gaps = 82/819 (10%)
Query: 29 PRIVEHPSDLI----VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
P + P D+I +SK E LNC A G P+P W + G TD D S+ L
Sbjct: 26 PIFTQEPHDVIFPLDLSKSE-VILNCAANGYPSPHYRWKQNG----TDIDFTMSYHYRLD 80
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAV 144
GSL ++ + D G+Y C+A N LG +S A L+ A + D + S V V
Sbjct: 81 GGSL----AINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVRE 136
Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPL---DDKDERITIRGGKLMITYTRKSDAGKYVC 201
G+ V+ C PP + + +W + +PL +D ++ G L I SD G Y C
Sbjct: 137 GQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTC 196
Query: 202 VGTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSAEFKCEARGDPV 251
TN +R + +++R V+ P + D S + +C A G+PV
Sbjct: 197 FITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPV 256
Query: 252 PTVRWRKDDGE-LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 310
P + WR+ DG LP + L+I D G Y C+A N+ G+ A L
Sbjct: 257 PDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYA 316
Query: 311 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 370
PP + K ++ +++ + ++C+A+G P P W + G + R + +
Sbjct: 317 PPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGER--------LNPEERIQI-E 367
Query: 371 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT--VA 428
G L IT + SD G Y C N I A L V P + PV + V
Sbjct: 368 NGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVL-----ASAPDFSKSPVKKKSFVQ 422
Query: 429 VDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 488
V G V+ C P I W++ G Q RI LE+G L+I D G YTCIA
Sbjct: 423 VGGDIVIGCKPNAFPRAAISWKR-GTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIA 481
Query: 489 STPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNS 548
+ G A + + V+E V PP D + S +V+ V W N
Sbjct: 482 TNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVW--FFNG 539
Query: 549 GATPTSYIIEAFSHASGSS-WQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPS 607
+ F G S + N++ S K L L + A + P
Sbjct: 540 DVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSG-KYLCTVQTTLESLSAVADIIVRGPP 598
Query: 608 QISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQG 667
+ V+ +D+ T+ + + N+ + + T+ + + V W I
Sbjct: 599 GPPEDVQVEDISSTTSQLSWRAGPD--NNSPIQIF--TIQTRTPFSVGWQAVATVPEILN 654
Query: 668 YKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSE-I 726
K + G S W+ +E R A NS+ I G SE
Sbjct: 655 GKTY---NATVVGLSPWVEYEFRVVAGNSIGI---------------------GEPSEPS 690
Query: 727 KFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC--LGNET- 783
+ +T P P V + G+ + ++++W+ PE+ QNG Y + +G+ T
Sbjct: 691 ELLRTKASVPVVAP--VNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTW 748
Query: 784 RYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 822
+V+ S F ++P + V+V G G
Sbjct: 749 SKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEG 787
Score = 176 bits (445), Expect = 2e-43
Identities = 191/715 (26%), Positives = 305/715 (42%), Gaps = 79/715 (11%)
Query: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITYTRKSD 195
P + A +EC G+P P ISW++ DGSPL K + + L I ++ D
Sbjct: 234 PETIQAAKDSSVKLECFA-LGNPVPDISWRRLDGSPLPGK-VKYSKSQAILEIPNFQQED 291
Query: 196 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 255
G Y C+ +N+ G R +L P + ++ N +++ D+ ++C+A G P P
Sbjct: 292 EGFYECIASNLRG-RNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYT 350
Query: 256 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV-QEPPH 313
W K+ L P+ R +I ++ TL I + D G Y C AEN A+A L V P
Sbjct: 351 WLKNGERLNPEERIQI-ENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPD 409
Query: 314 FVVKP--RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
F P + V +G + C+ P+ AI W+R G++ L + S R + +
Sbjct: 410 FSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKR-GTETL-------RQSKRIFLLED 461
Query: 372 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 431
G L I N+ RSD G Y C N G+ L ++ +R VI P V V
Sbjct: 462 GSLKIYNITRSDAGSYTCIATNQFGTAKNTGSL----IVKERT--VITVPPSKMDVTVGE 515
Query: 432 TFVLSCVATGSPVPTIL--WRKDGVLVSTQDS-----RIKQLENGVLQIRYAKLGDTGRY 484
+ VL C + P ++ W +G ++ + RI G L IR +L +G+Y
Sbjct: 516 SIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKY 575
Query: 485 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 544
C T + A I V+ PP P P +V D+S T LSW+
Sbjct: 576 LCTVQTTLESLSAVADIIVRG------PPGP---------PEDVQVEDISSTTSQLSWRA 620
Query: 545 NLNSGATPTSYIIEAFSHASGSSWQTVAE-----NVKTETSAIKGLKPNAIYLFLVRAAN 599
++ + + I+ + S WQ VA N KT + + GL P Y F V A N
Sbjct: 621 GPDNNSPIQIFTIQTRTPFS-VGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGN 679
Query: 600 AYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TV 658
+ GI +PS+ S+ ++T+ +P A +++H S S + + W ++
Sbjct: 680 SIGIGEPSEPSELLRTKASVPVV--------------APVNIHGGGG-SRSELVITWESI 724
Query: 659 DQQSQYIQ--GYKILYRPSGANHGESDWL--VFEVRTPAKNSVVIPDLRKGVNYEIKARP 714
++ Q + GY I++RP G+ + + V R +N +IP +E+K
Sbjct: 725 PEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIP----LSPFEVKVGV 780
Query: 715 FFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 774
+ NE +G+ S + + E+ P P+G S + + + VSW + G V Y
Sbjct: 781 YNNEGEGSLSTVTIVYSGEDEPQLAPRG--TSLQSFSASEMEVSWNAIAWNRNTGRVLGY 838
Query: 775 KV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 827
+V W ++ V G+ + I L Y V A AG+G S P
Sbjct: 839 EVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPP 893
Score = 140 bits (353), Expect = 1e-32
Identities = 193/844 (22%), Positives = 326/844 (38%), Gaps = 99/844 (11%)
Query: 26 DFPPRI-VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
++ P+I V P + +K L C A G P P I W + D +
Sbjct: 224 EYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDISWRR--------LDGSPLPGKVKY 275
Query: 85 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAV 144
S S L I + ++ DEG Y C+A N G ++ + A ++ Q + +++
Sbjct: 276 SKSQAILEIPNFQQE--DEGFYECIASNLRGRNLAKGQLIFYA--PPEWEQKIQNTHLSI 331
Query: 145 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT 204
+ + EC+ G P P +W K+G L+ +ERI I G L+IT SD+G Y C
Sbjct: 332 YDNLLWECKAS-GKPNPWYTWLKNGERLNP-EERIQIENGTLIITMLNVSDSGVYQCAAE 389
Query: 205 NMVGERESEVAELTVL-ERPSFVKRP--SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
N + AEL VL P F K P V V C+ P + W++
Sbjct: 390 NKYQIIYAN-AELRVLASAPDFSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKRGTE 448
Query: 262 ELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRD 320
L +S R + +D +LKI +T D GSYTC+A N G A+ + +L V+E V P
Sbjct: 449 TLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQFGTAKNTGSLIVKERTVITVPPSK 508
Query: 321 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 380
V +G ++ C+ + +P + + + +++ + R GDL I N+Q
Sbjct: 509 MDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQ 568
Query: 381 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 440
G Y+C S+ V D+I PP GP D
Sbjct: 569 LHHSGKYLCTVQTTLESLSA-----VADIIVRGPP-----GPPEDVQVED---------I 609
Query: 441 GSPVPTILWR-----KDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIASTPSG 493
S + WR + + T +R V + G T T + +P
Sbjct: 610 SSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQAVATVPEILNGKTYNATVVGLSP-- 667
Query: 494 EATWSAYIEVQEFGVPVQPPRPTDPN-LIPSAPSKPEVTDV-------SRNTVTLSWQ-- 543
W Y G + P++P+ L+ + S P V V SR+ + ++W+
Sbjct: 668 ---WVEYEFRVVAGNSIGIGEPSEPSELLRTKASVPVVAPVNIHGGGGSRSELVITWESI 724
Query: 544 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGI 603
P YII F ++W K + S+++ + F+ R + +
Sbjct: 725 PEELQNGEGFGYII-MFRPVGSTTWS------KEKVSSVESSR------FVYRNESIIPL 771
Query: 604 SDPSQISDPV---KTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV-- 658
S P ++ V + + L T V + + +L L + S+S +EV W
Sbjct: 772 S-PFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAPRGTSLQS---FSASEMEVSWNAIA 827
Query: 659 -DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFN 717
++ + + GY++LY + + KN I L+ Y R +
Sbjct: 828 WNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTTKN---ITGLKANTIYFASVRAYNT 884
Query: 718 EFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW 777
G S T + PS PP + + + + ++W+ V YK+
Sbjct: 885 AGTGPSSPPVNVTTKKSPPSQPPANIAWKLTN---SKLCLNWEHVKTMENESEVLGYKIL 941
Query: 778 CLGN-ETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE----PQFIQL 832
N +++ HI +T + ++ +++PF Y +E+ + G G SE P+ L
Sbjct: 942 YRQNRQSKTHILET-NNTSAELLVPFEED---YLIEIRTVSDGGDGSSSEEIRIPKMSSL 997
Query: 833 DAHG 836
+ G
Sbjct: 998 SSRG 1001
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 193 bits (490), Expect = 1e-48
Identities = 126/373 (33%), Positives = 185/373 (49%), Gaps = 21/373 (5%)
Query: 137 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKS 194
P DV V G C+ G+P+P I W + LD + D R+ + G LMI TR+S
Sbjct: 240 PQDVEVPSGNTVYFTCRA-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
Query: 195 DAGKYVCVGTNMVGERESEVAEL---TVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
D G Y C+ N GE +++ A L ++ +PSFV +P + V + S +C A G P
Sbjct: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
Query: 252 PTVRWRKDDG-ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 310
P + W +D+G EL SR+ + L ++ +T D G +TC A N G +A+A + VQ
Sbjct: 359 PLITWTRDNGLELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
Query: 311 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 370
PP F V P+DQVV V + CEA GNP P I W + G Q + + +V
Sbjct: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EGQHTVLS 469
Query: 371 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 430
+G L I + D G Y CQ ++ G + K +++T + + V Q P + +V V
Sbjct: 470 SGTLRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLT--VKPKALAVFTQLPQDTSVEVG 525
Query: 431 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 490
+SC A G P P I W K+GV + T+ + + G L I A D GRY C+A
Sbjct: 526 KNINISCHAQGEPQPIITWNKEGVQI-TESGKFHVDDEGTLTIYDAGFPDQGRYECVARN 584
Query: 491 PSGEATWSAYIEV 503
G A + ++ V
Sbjct: 585 SFGLAVTNMFLTV 597
Score = 185 bits (469), Expect = 4e-46
Identities = 123/386 (31%), Positives = 179/386 (46%), Gaps = 24/386 (6%)
Query: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
PRI P D+ V G C+AEG P P I W ++ + DD R + + G+L
Sbjct: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLN--VFDDGTL 290
Query: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL--RDDFRQNPSDVMVAVGE 146
I + R+S D+GVY C+ARN GEA + +A L + L + F P D V +G
Sbjct: 291 M---IRNTRES--DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
+EC GHP P I+W +D D + G + T++ D G++ C N
Sbjct: 346 STTLECM-ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR-DHGRFTCHANNS 403
Query: 207 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-K 265
G ++ A + V P F P + V + + E+ CEA G+P P + W K G+LP +
Sbjct: 404 HGTVQA-AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
Query: 266 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP--PHFVVKPRDQVV 323
++ + TL+I + D G Y C A + +G + S LTV+ F P+D V
Sbjct: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSV 522
Query: 324 ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 383
+G+ + C A G PQP I W +EG Q S +F V G LTI + D
Sbjct: 523 EVGKNINISCHAQGEPQPIITWNKEGVQ--------ITESGKFHVDDEGTLTIYDAGFPD 574
Query: 384 VGYYICQTLNVAGSIITKAYLEVTDV 409
G Y C N G +T +L VT +
Sbjct: 575 QGRYECVARNSFGLAVTNMFLTVTAI 600
Score = 128 bits (321), Expect = 5e-29
Identities = 91/318 (28%), Positives = 142/318 (44%), Gaps = 27/318 (8%)
Query: 214 VAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKS 266
VA +TV E P P ++ V ++ F C A G+P P + W ++ L +
Sbjct: 221 VASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDT 280
Query: 267 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL----TVQEPPHFVVKPRDQV 322
R + DD TL IR D G Y C+A N G+A+ + + ++ P FV++P+D
Sbjct: 281 RLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE 340
Query: 323 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 382
V +G + T +C ATG+P P I W R+ L SR + +G L + N+ +
Sbjct: 341 VLIGTSTTLECMATGHPHPLITWTRDNGLEL--------DGSRHVATSSG-LYLQNITQR 391
Query: 383 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 442
D G + C N G++ A + V + PP P +Q V + C A G+
Sbjct: 392 DHGRFTCHANNSHGTVQAAANIIV------QAPPQFTVTPKDQVVLEEHAVEWLCEADGN 445
Query: 443 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 502
P P I+W K G + + L +G L+I A D G+Y C A + G S +
Sbjct: 446 PPPVIVWTKTGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLT 504
Query: 503 VQEFGVPVQPPRPTDPNL 520
V+ + V P D ++
Sbjct: 505 VKPKALAVFTQLPQDTSV 522
Score = 90.9 bits (224), Expect = 9e-18
Identities = 68/207 (32%), Positives = 95/207 (45%), Gaps = 14/207 (6%)
Query: 302 ASATLTVQE----PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 357
A A++TV+E P +P+D V G TV F C A GNP+P I W L
Sbjct: 220 AVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL--- 276
Query: 358 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 417
+ +R +V G L I N + SD G Y C N AG T++ + + +P V
Sbjct: 277 ---EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFV 333
Query: 418 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 477
I+ P + V + + L C+ATG P P I W +D L SR +G L ++
Sbjct: 334 IQ--PQDTEVLIGTSTTLECMATGHPHPLITWTRDNGL-ELDGSRHVATSSG-LYLQNIT 389
Query: 478 LGDTGRYTCIASTPSGEATWSAYIEVQ 504
D GR+TC A+ G +A I VQ
Sbjct: 390 QRDHGRFTCHANNSHGTVQAAANIIVQ 416
Score = 73.2 bits (178), Expect = 2e-12
Identities = 56/182 (30%), Positives = 84/182 (46%), Gaps = 13/182 (7%)
Query: 28 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 87
PP+ P D +V + C+A+G P P I W K G ++ + +L SG+
Sbjct: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE-----GQHTVLSSGT 472
Query: 88 LFFLRIVHGRKSRPDEGVYVCVARNYLG-EAVSHNASLEVAILRDDFRQNPSDVMVAVGE 146
LRI R ++ D+G Y C A + LG + VS +++ L F Q P D V VG+
Sbjct: 473 ---LRI--DRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALA-VFTQLPQDTSVEVGK 526
Query: 147 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 206
+ C +G P+P I+W K+G + + + G L I D G+Y CV N
Sbjct: 527 NINISCH-AQGEPQPIITWNKEGVQITESGKFHVDDEGTLTIYDAGFPDQGRYECVARNS 585
Query: 207 VG 208
G
Sbjct: 586 FG 587
>gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]
Length = 1007
Score = 192 bits (489), Expect = 2e-48
Identities = 276/1084 (25%), Positives = 414/1084 (38%), Gaps = 154/1084 (14%)
Query: 410 IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST---------QD 460
+A PP I P +Q G +SC A+G P PTI W +G +S D
Sbjct: 26 MAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPD 85
Query: 461 SRIKQLE---NGVLQIRYAKLGDTGRYTCIASTPSGEAT-----WSAYIEVQEFGVPVQP 512
+ L+ G A D G YTC AS G A S + ++F +
Sbjct: 86 GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQI---- 141
Query: 513 PRPTDPNLIPSAPSKPEVTDV-SRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTV 571
+P D + E T+SW + A ++ H +
Sbjct: 142 -QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLA------LQPGRHTVSGGSLLM 194
Query: 572 AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQ 631
A K++ + N+ RAA I +P ++PV
Sbjct: 195 ARAEKSDEGTYMCVATNSAGHRESRAARV-SIQEPQDYTEPV------------------ 235
Query: 632 RELGNAVLHLHNPTVLSSSSIE---------VHWTVDQQSQYIQGYKILYRPSGANHGE- 681
EL + L N T+L+ E + W V + Q Y L+R A G+
Sbjct: 236 -ELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQG 294
Query: 682 SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ 741
+ W E S + L G +YE K RP +G DS + + E+ PSAPPQ
Sbjct: 295 APWA--EELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQ 352
Query: 742 GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 801
VT+ GNGT + VSW PPP + NG+++ Y+VW LGN + N TV G + I
Sbjct: 353 EVTLKP--GNGT-VFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIA 409
Query: 802 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS---LAQQISDVVKQP 858
+PG Y V+VAA TGAG+G S P + L+ + E +Q+ +K+P
Sbjct: 410 THMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRP 468
Query: 859 AFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVS 918
IA G A W++L+ ++ ++R R+ R L P + +A+
Sbjct: 469 EVIATCGVALWLLLLGTAVCIHRRRRARVHL---------------GPGLYRYTSEDAI- 512
Query: 919 SGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIA 978
L + + + WLADTW +T + D S S + +D+ P DC
Sbjct: 513 ------LKHRMDHSDSQWLADTWRSTSGS-RDLSSSSSLSSRLGADAR-----DPLDCRR 560
Query: 979 NYNNQLDNKQTNLMLPE-STVYGDVDLSNKINEMKTFNSPNLKDGRFVNP--SGQPTPYA 1035
+ + +LP+ ST YG + ++ + SP + R + P + +P +
Sbjct: 561 SLLSWDSRSPGVPLLPDTSTFYGSL-IAELPSSTPARPSPQVPAVRRLPPQLAQLSSPCS 619
Query: 1036 TTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPP 1095
++ + S + S E WK ++KQE+ + + + + + RA +
Sbjct: 620 SSDSLCSRRGLSSPRLSLAPAEA-WK--AKKKQELQHANSSPLLRGSHSLELRACEL--- 673
Query: 1096 TIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP--AH 1153
N G S G+ + A PK+ LPP P H
Sbjct: 674 ---------GNRGSKNLSQSPGAVPQALVAWR--ALGPKLLSSSNELVTRHLPPAPLFPH 722
Query: 1154 PPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAA 1213
P + S++ V + P P + + P SS +
Sbjct: 723 ETPPTQSQQTQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSSSL 782
Query: 1214 VSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYG 1273
S + LTP EE+ L+ + + R VS P PR SPP TYG
Sbjct: 783 SSLGEDQDSVLTP---EEVALCLE--------LSEGEETPRNSVS--PMPRAPSPPTTYG 829
Query: 1274 YISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMIN 1333
YIS P S+ TD + R L TP S GS+ N
Sbjct: 830 YISVPTASEF-TDMGRTGGGVGPKGGVLLCPPRPCL-----TPTPS--------EGSLAN 875
Query: 1334 GWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHF 1393
GWGSASE++ S+ S VSSSDGSF DA FA+A+A A + G + R+ A
Sbjct: 876 GWGSASEDNAASARASLVSSSDGSFLADAHFARALAVAVDSFGFGLEPRE----ADCVFI 931
Query: 1394 HASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKS 1453
AS P P + N+S + + RP + H +R +PP P P I S
Sbjct: 932 DASSPPSPRDEIFLTPNLSLPLWE-WRPDWLEDMEVSHTQR--LGRGMPPWP-PDSQISS 987
Query: 1454 PTAQ 1457
+Q
Sbjct: 988 QRSQ 991
Score = 176 bits (446), Expect = 2e-43
Identities = 92/218 (42%), Positives = 123/218 (56%), Gaps = 9/218 (4%)
Query: 25 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 84
+D PP+I+ HP D + PA ++C+A G+P PTI W G+ + DP LLP
Sbjct: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
Query: 85 SGSLFFLR------IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 138
G+L L+ G+ D GVY C A N LG AVS A L VA+LR+DF+ P
Sbjct: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
Query: 139 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 198
D++ VGE +EC PP GHPEPT+SW KDG PL + R T+ GG L++ KSD G
Sbjct: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
Query: 199 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 236
Y+CV TN G RES A +++ E + + LAV +
Sbjct: 205 YMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRI 242
Score = 77.4 bits (189), Expect = 1e-13
Identities = 101/423 (23%), Positives = 158/423 (37%), Gaps = 58/423 (13%)
Query: 223 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIR 279
P + P + A C+A G P PT+RW + L P + + D TL +
Sbjct: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
Query: 280 KVTA-----------GDMGSYTCVAENMVGKA-EASATLTVQE-PPHFVVKPRDQVVALG 326
+ A D+G YTC A N +G A A L+V F ++PRD V +G
Sbjct: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVG 151
Query: 327 RTVTFQC-EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 385
T +C G+P+P + W ++G + QP R +VS G L + ++SD G
Sbjct: 152 EQFTLECGPPWGHPEPTVSWWKDGKP---LALQP----GRHTVS-GGSLLMARAEKSDEG 203
Query: 386 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 445
Y+C N AG ++A D PV + + ++ +L+ P P
Sbjct: 204 TYMCVATNSAGHRESRAARVSIQEPQDYTEPV---ELLAVRIQLENVTLLNPDPAEGPKP 260
Query: 446 T----ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT--CIASTPSGEATWSA 499
+ W+ G Q + + + A G + +A S E
Sbjct: 261 RPAVWLSWKVSGPAAPAQS------YTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLH 314
Query: 500 YIEVQEFGVPVQPPRPTDPN----------LIPSAPSKPEVTDVSRNTVTLSW--QPNLN 547
+ + EF V R P+ +PSAP + TV +SW P N
Sbjct: 315 WGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAEN 374
Query: 548 SGATPTSYIIEAFSHAS--GSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD 605
Y + + + S ++W V E + E I P + Y V A G +
Sbjct: 375 HNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLE---IATHMPGS-YCVQVAAVTGAGAGE 430
Query: 606 PSQ 608
PS+
Sbjct: 431 PSR 433
Score = 73.6 bits (179), Expect = 1e-12
Identities = 65/225 (28%), Positives = 93/225 (41%), Gaps = 24/225 (10%)
Query: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD--DKDERITIRGGKLMITY--- 190
+P D + PA M CQ G P PTI W +G PL D + G L++
Sbjct: 37 HPQDQLFQGPGPARMSCQAS-GQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPA 95
Query: 191 --------TRKSDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAE 241
+D G Y C +N +G S A L+V + R F +P ++ V +
Sbjct: 96 RGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFT 155
Query: 242 FKCEAR-GDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 298
+C G P PTV W KD L R+ + L R D G+Y CVA N G
Sbjct: 156 LECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMAR-AEKSDEGTYMCVATNSAG 214
Query: 299 KAEA-SATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 342
E+ +A +++QEP + + V L + + NP PA
Sbjct: 215 HRESRAARVSIQEPQDYT----EPVELLAVRIQLENVTLLNPDPA 255
Score = 68.2 bits (165), Expect = 6e-11
Identities = 81/320 (25%), Positives = 121/320 (37%), Gaps = 54/320 (16%)
Query: 311 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS--------------QNLLFS 356
PP +V P+DQ+ C+A+G P P I W G L
Sbjct: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
Query: 357 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK-AYLEVTDVIADRPP 415
QPP G +D+G Y C+ N G+ +++ A L V + D
Sbjct: 91 LQPP---------ARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED--- 138
Query: 416 PVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 474
+ P + V F L C G P PT+ W KDG ++ Q R + G L +
Sbjct: 139 --FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMA 195
Query: 475 YAKLGDTGRYTCIASTPSG-EATWSAYIEVQE----------FGVPVQPPRPTDPNLIPS 523
A+ D G Y C+A+ +G + +A + +QE V +Q T N P+
Sbjct: 196 RAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPA 255
Query: 524 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF--SHASGSSWQTVAENVKT--ET 579
KP R V LSW+ ++ A P F A G AE + ++
Sbjct: 256 EGPKP------RPAVWLSWK--VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQS 307
Query: 580 SAIKGLKPNAIYLFLVRAAN 599
+ + GL Y F VR ++
Sbjct: 308 AELGGLHWGQDYEFKVRPSS 327
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 74,994,146
Number of Sequences: 37866
Number of extensions: 4179051
Number of successful extensions: 35218
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 306
Number of HSP's successfully gapped in prelim test: 731
Number of HSP's that attempted gapping in prelim test: 18852
Number of HSP's gapped (non-prelim): 8861
length of query: 1612
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1496
effective length of database: 13,855,062
effective search space: 20727172752
effective search space used: 20727172752
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.