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Search of human proteins with 194097477
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
(802 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194097477 neuronal PAS domain protein 4 [Homo sapiens] 1632 0.0
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 110 4e-24
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 106 1e-22
gi|21614542 single-minded homolog 1 [Homo sapiens] 96 1e-19
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 96 1e-19
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 96 1e-19
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 92 2e-18
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 90 7e-18
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 90 7e-18
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 88 3e-17
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 87 8e-17
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 86 1e-16
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 78 4e-14
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 70 8e-12
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens] 59 1e-08
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 59 2e-08
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 59 2e-08
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 59 2e-08
gi|222352122 hypothetical protein LOC284297 [Homo sapiens] 56 1e-07
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 55 3e-07
gi|4502231 aryl hydrocarbon receptor nuclear translocator isofor... 55 3e-07
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 54 6e-07
gi|4758010 clock [Homo sapiens] 54 8e-07
gi|163965366 nascent polypeptide-associated complex alpha subuni... 53 1e-06
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap... 50 6e-06
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap... 50 6e-06
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi... 50 6e-06
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 50 8e-06
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 50 8e-06
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 50 1e-05
>gi|194097477 neuronal PAS domain protein 4 [Homo sapiens]
Length = 802
Score = 1632 bits (4227), Expect = 0.0
Identities = 802/802 (100%), Positives = 802/802 (100%)
Query: 1 MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGT 60
MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGT
Sbjct: 1 MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGT 60
Query: 61 PLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIY 120
PLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIY
Sbjct: 61 PLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIY 120
Query: 121 DIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGA 180
DIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGA
Sbjct: 121 DIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGA 180
Query: 181 YWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGF 240
YWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGF
Sbjct: 181 YWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGF 240
Query: 241 ERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYS 300
ERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYS
Sbjct: 241 ERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYS 300
Query: 301 EGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTN 360
EGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTN
Sbjct: 301 EGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTN 360
Query: 361 PLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDL 420
PLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDL
Sbjct: 361 PLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDL 420
Query: 421 VCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDP 480
VCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDP
Sbjct: 421 VCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDP 480
Query: 481 LTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQA 540
LTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQA
Sbjct: 481 LTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQA 540
Query: 541 HLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSV 600
HLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSV
Sbjct: 541 HLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSV 600
Query: 601 DVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE 660
DVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE
Sbjct: 601 DVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE 660
Query: 661 PLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTP 720
PLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTP
Sbjct: 661 PLGGLEPLDSNLSLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIFMDLSTP 720
Query: 721 DPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDEL 780
DPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDEL
Sbjct: 721 DPSEEWGSGDPEAEGPGGAPSPCNNLSPEDHSFLEDLATYETAFETGVSAFPYDGFTDEL 780
Query: 781 HQLQSQVQDSFHEDGSGGEPTF 802
HQLQSQVQDSFHEDGSGGEPTF
Sbjct: 781 HQLQSQVQDSFHEDGSGGEPTF 802
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 110 bits (276), Expect = 4e-24
Identities = 157/634 (24%), Positives = 251/634 (39%), Gaps = 96/634 (15%)
Query: 1 MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFF---- 56
M +K A+K RR++ N E L +LLPL A +L I+ L Y + F
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
Query: 57 --AGGTPL-AGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLV 113
A G P AGP ++ + ++ L GF+ V ++GK++Y+SE+ S HLG S V+L
Sbjct: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
Query: 114 AQGDSIYDIIDPADH------LTVRQQL--TLPSALDTDRLFRCRFNTSKSLRRQS---A 162
G+SIY+ I P+DH LT Q L L + +R F R + R +
Sbjct: 121 --GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCS 178
Query: 163 GNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPAS---LFLAMFQS 219
G K++ G Y ++ + C + G P + L+ MF
Sbjct: 179 GYKVIHCSGYLKIR---QYMLDMSLYDS-CYQIVGLVAVGQSLPPSAITEIKLYSNMFMF 234
Query: 220 RHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAE 279
R + DL L+ + V G+E +L+ K+ Y +H D+ H H+ LL + G + +
Sbjct: 235 RASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVK-GQVTTK 293
Query: 280 MVVRLQAKTGGWAWIY---CLLYSEGPEGP--ITANNYPISDMEAWSLR---QQLNSEDT 331
RL +K GGW W+ ++++ P I + NY ++++E L+ +Q+++ +
Sbjct: 294 -YYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKS 352
Query: 332 QAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELP 391
Q ++ T SQE P T R+ +P S E
Sbjct: 353 QDSWRTALST----------SQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECG 402
Query: 392 RPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTP 451
+ + + PE +E S DL+ TP Y + FS H H P
Sbjct: 403 QLGNWRASPPASAAAPPELQPHSE-SSDLLYTPSY--------SLPFSYH---YGHFPLD 450
Query: 452 SSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQ 511
S FS + A F P SP + S + C + +
Sbjct: 451 SH-----------VFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGE---CQWHYANP 496
Query: 512 LLPSTAT----FPEPLGSPAHEQLTPPSTAFQAHL-----DSPSQTFPE--------QLS 554
L+PS+++ PEP + A L P A A + D+ +FP L
Sbjct: 497 LVPSSSSPAKNPPEPPANTARHSLVPSYEAPAAAVRRFGEDTAPPSFPSCGHYREEPALG 556
Query: 555 PNPTKTYFAQEGCSFLYEK------LPPSPSSPG 582
P A++G + PP+P +PG
Sbjct: 557 PAKAARQAARDGARLALARAAPECCAPPTPEAPG 590
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 106 bits (264), Expect = 1e-22
Identities = 143/566 (25%), Positives = 229/566 (40%), Gaps = 77/566 (13%)
Query: 1 MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFF---- 56
M +K A+K RR++ N E L +LLPL A +L I+ L Y + F
Sbjct: 1 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL 60
Query: 57 --AGGTPL-AGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLV 113
A G P AGP ++ + ++ L GF+ V ++GK++Y+SE+ S HLG S V+L
Sbjct: 61 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT 120
Query: 114 AQGDSIYDIIDPADH------LTVRQQL--TLPSALDTDRLFRCRFNTSKSLRRQS---A 162
G+SIY+ I P+DH LT Q L L + +R F R + R +
Sbjct: 121 --GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCS 178
Query: 163 GNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPAS---LFLAMFQS 219
G K++ G Y ++ + C + G P + L+ MF
Sbjct: 179 GYKVIHCSGYLKIR---QYMLDMSLYDS-CYQIVGLVAVGQSLPPSAITEIKLYSNMFMF 234
Query: 220 RHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAE 279
R + DL L+ + V G+E +L+ K+ Y +H D+ H H+ LL + G + +
Sbjct: 235 RASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVK-GQVTTK 293
Query: 280 MVVRLQAKTGGWAWIY---CLLYSEGPEGP--ITANNYPISDMEAWSLR---QQLNSEDT 331
RL +K GGW W+ ++++ P I + NY ++++E L+ +Q+++ +
Sbjct: 294 -YYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKS 352
Query: 332 QAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELP 391
Q ++ T SQE P T R+ +P S E
Sbjct: 353 QDSWRTALST----------SQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECG 402
Query: 392 RPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTP 451
+ + + PE +E S DL+ TP Y + FS H H P
Sbjct: 403 QLGNWRASPPASAAAPPELQPHSE-SSDLLYTPSY--------SLPFSYH---YGHFPLD 450
Query: 452 SSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQ 511
S FS + A F P SP + S + C + +
Sbjct: 451 SH-----------VFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGE---CQWHYANP 496
Query: 512 LLPSTAT----FPEPLGSPAHEQLTP 533
L+PS+++ PEP + A L P
Sbjct: 497 LVPSSSSPAKNPPEPPANTARHSLVP 522
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 96.3 bits (238), Expect = 1e-19
Identities = 99/380 (26%), Positives = 154/380 (40%), Gaps = 44/380 (11%)
Query: 1 MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGT 60
M +K A++ RR++ N+E L +LLPL A +L I+ L Y + V F G
Sbjct: 1 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL 60
Query: 61 PLA-------GPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLV 113
A P + + ++ L GF+ V +GK++Y+SE+ S HLG S V+L
Sbjct: 61 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT 120
Query: 114 AQGDSIYDIIDPADHLTVRQQLT--------LPSALDTDRLFRCRFNTSKSLRRQS---A 162
G+SIY+ I PADH + LT + +R F R + R
Sbjct: 121 --GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCG 178
Query: 163 GNKLVLIRGRFHAHP--------PGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFL 214
G K++ G G Y N A L P L
Sbjct: 179 GYKVIHCSGYLKIRQYSLDMSPFDGCY--QNVGLVAVGHSLPP-------SAVTEIKLHS 229
Query: 215 AMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESG 274
MF R + D+ L+ + V G+E +L+ K+ Y +H D H H+ LL + G
Sbjct: 230 NMFMFRASLDMKLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVK-G 288
Query: 275 DIQAEMVVRLQAKTGGWAWIY---CLLYSEGPEGP--ITANNYPISDMEAWSLRQQLNSE 329
+ + R AK GGW W+ ++++ P I + NY ++D E L+ L+
Sbjct: 289 QVTTK-YYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQI 347
Query: 330 DTQAAYVLGTPTMLPSFPEN 349
T + P+ +N
Sbjct: 348 SASKPAFSYTSSSTPTMTDN 367
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 95.9 bits (237), Expect = 1e-19
Identities = 118/447 (26%), Positives = 181/447 (40%), Gaps = 45/447 (10%)
Query: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGG--TPL 62
++ A+++RR Q + L LP A L IM L Y R A G +
Sbjct: 17 SRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQV 76
Query: 63 AGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDI 122
L A L+ AL GF++V TAEG + YLSE+VS+HLG S ++L+ G SI+D
Sbjct: 77 GAGGEPLDACYLK----ALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI--GHSIFDF 130
Query: 123 IDPADHLTVRQQLTLPSALD-------TDRLFRCRFNTS-----KSLRRQSAGNKLVLIR 170
I P D ++ LT L T+R F R ++ ++L ++A K++
Sbjct: 131 IHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCS 190
Query: 171 GRFHAHPPGAYW--AGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALL 228
G A+ P A AG+P L P PG L F SRH+ D+
Sbjct: 191 GHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFT 250
Query: 229 DISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKT 288
+ + G+ +L+ S Y +H D S + LL++ + + R A++
Sbjct: 251 YCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ--YRFLARS 308
Query: 289 GGWAWIYC-LLYSEGPEGP----ITANNYPISDMEAWSLRQQLNSEDTQAAYVL--GTPT 341
GG+ W G GP I ++ IS +E + L + + + G P
Sbjct: 309 GGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAP- 367
Query: 342 MLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSY 401
SQ++ + NP + PR +F P LS + + + PR D
Sbjct: 368 ----------SQKD--TPNPGDSLDTPGPRILAFLHPPSLSEAALAAD-PRRFCSPDLRR 414
Query: 402 LTFPSGPEPSLQAELSKDLVCTPPYTP 428
L P S+ A S L P +P
Sbjct: 415 LLGPILDGASVAATPSTPLATRHPQSP 441
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 95.9 bits (237), Expect = 1e-19
Identities = 118/447 (26%), Positives = 181/447 (40%), Gaps = 45/447 (10%)
Query: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGG--TPL 62
++ A+++RR Q + L LP A L IM L Y R A G +
Sbjct: 19 SRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQV 78
Query: 63 AGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDI 122
L A L+ AL GF++V TAEG + YLSE+VS+HLG S ++L+ G SI+D
Sbjct: 79 GAGGEPLDACYLK----ALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELI--GHSIFDF 132
Query: 123 IDPADHLTVRQQLTLPSALD-------TDRLFRCRFNTS-----KSLRRQSAGNKLVLIR 170
I P D ++ LT L T+R F R ++ ++L ++A K++
Sbjct: 133 IHPCDQEELQDALTPQQTLSRRKVEAPTERCFSLRMKSTLTSRGRTLNLKAATWKVLNCS 192
Query: 171 GRFHAHPPGAYW--AGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALL 228
G A+ P A AG+P L P PG L F SRH+ D+
Sbjct: 193 GHMRAYKPPAQTSPAGSPDSEPPLQCLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFT 252
Query: 229 DISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKT 288
+ + G+ +L+ S Y +H D S + LL++ + + R A++
Sbjct: 253 YCDDRIAEVAGYSPDDLIGCSAYEYIHALDSDAVSKSIHTLLSKGQAVTGQ--YRFLARS 310
Query: 289 GGWAWIYC-LLYSEGPEGP----ITANNYPISDMEAWSLRQQLNSEDTQAAYVL--GTPT 341
GG+ W G GP I ++ IS +E + L + + + G P
Sbjct: 311 GGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRRPIQRGAP- 369
Query: 342 MLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSY 401
SQ++ + NP + PR +F P LS + + + PR D
Sbjct: 370 ----------SQKD--TPNPGDSLDTPGPRILAFLHPPSLSEAALAAD-PRRFCSPDLRR 416
Query: 402 LTFPSGPEPSLQAELSKDLVCTPPYTP 428
L P S+ A S L P +P
Sbjct: 417 LLGPILDGASVAATPSTPLATRHPQSP 443
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 91.7 bits (226), Expect = 2e-18
Identities = 97/350 (27%), Positives = 143/350 (40%), Gaps = 79/350 (22%)
Query: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAG 64
++ A+++RR + N E L +LLPL A +L I+ L+ Y R F A G P G
Sbjct: 50 SRNAARSRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWG 109
Query: 65 ------PTGL---------LSAQELED-----IVAALPGFLLVFTAEGKLLYLSESVSEH 104
P GL L ++ E I+ +L GF+ EGK LY+SE+VS +
Sbjct: 110 LRAAGPPAGLAPGRRGPAALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIY 169
Query: 105 LGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTL--------------------------- 137
LG S V++ G S++D I P DH V +QL L
Sbjct: 170 LGLSQVEMT--GSSVFDYIHPGDHSEVLEQLGLRTPTPGPPTPPSVSSSSSSSSSLADTP 227
Query: 138 ----------PSALDTDRLFRCRFN---TSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAG 184
PS+L +R F R T + L +++G K++ + GR AH G G
Sbjct: 228 EIEASLTKVPPSSLVQERSFFVRMKSTLTKRGLHVKASGYKVIHVTGRLRAHALGLVALG 287
Query: 185 NPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSE 244
+ T APL P G M R + L +L V ++ SE
Sbjct: 288 H---TLPPAPLAELPLHG------------HMIVFRLSLGLTILACESRVSDHMDLGPSE 332
Query: 245 LLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWI 294
L+ +S Y +H +D H LL + G + LQ + GG+ W+
Sbjct: 333 LVGRSCYQFVHGQDATRIRQSHVDLL-DKGQVMTGYYRWLQ-RAGGFVWL 380
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 90.1 bits (222), Expect = 7e-18
Identities = 80/309 (25%), Positives = 136/309 (44%), Gaps = 32/309 (10%)
Query: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTR-KGVFFAGGTPLA 63
++ A+++RR + + L LPL L +M L Y R + + AG +
Sbjct: 22 SRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIE 81
Query: 64 GPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDII 123
+ AQ + AL GF++V T +G ++Y+S++V++++G + +L G S++D
Sbjct: 82 DD---MKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELT--GHSVFDFT 136
Query: 124 DPADHLTVRQQLTLPSAL-------DTDRLFRCRFNTS-----KSLRRQSAGNKLVLIRG 171
P DH +R+ LT + L +T R F R + +++ +SA K++ G
Sbjct: 137 HPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTG 196
Query: 172 RFHAH------PPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDL 225
H + P Y P T EP P P P + FL SRH+ D+
Sbjct: 197 HIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFL----SRHSLDM 250
Query: 226 ALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQ 285
E + +G+E ELL +S Y H D H + H+ + + + R+
Sbjct: 251 KFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQ--YRML 308
Query: 286 AKTGGWAWI 294
AK GG+ W+
Sbjct: 309 AKRGGYVWV 317
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 90.1 bits (222), Expect = 7e-18
Identities = 80/309 (25%), Positives = 136/309 (44%), Gaps = 32/309 (10%)
Query: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTR-KGVFFAGGTPLA 63
++ A+++RR + + L LPL L +M L Y R + + AG +
Sbjct: 22 SRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIE 81
Query: 64 GPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDII 123
+ AQ + AL GF++V T +G ++Y+S++V++++G + +L G S++D
Sbjct: 82 DD---MKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELT--GHSVFDFT 136
Query: 124 DPADHLTVRQQLTLPSAL-------DTDRLFRCRFNTS-----KSLRRQSAGNKLVLIRG 171
P DH +R+ LT + L +T R F R + +++ +SA K++ G
Sbjct: 137 HPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTG 196
Query: 172 RFHAH------PPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDL 225
H + P Y P T EP P P P + FL SRH+ D+
Sbjct: 197 HIHVYDTNSNQPQCGY--KKPPMTCLVLICEPIPHPSNIEIPLDSKTFL----SRHSLDM 250
Query: 226 ALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQ 285
E + +G+E ELL +S Y H D H + H+ + + + R+
Sbjct: 251 KFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQ--YRML 308
Query: 286 AKTGGWAWI 294
AK GG+ W+
Sbjct: 309 AKRGGYVWV 317
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 88.2 bits (217), Expect = 3e-17
Identities = 84/339 (24%), Positives = 150/339 (44%), Gaps = 34/339 (10%)
Query: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAG 64
++ A++ RR + L LPL + L IM LA + R +
Sbjct: 19 SRDAARCRRSKETEVFYELAHELPLPHSVSSHLDKASIMRLAISFLRTHKLLSSVCS-EN 77
Query: 65 PTGLLSAQELEDI-VAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDII 123
+ + Q+++++ + AL GF+ V T +G +++LSE++S+ +G + V+L G SI+D
Sbjct: 78 ESEAEADQQMDNLYLKALEGFIAVVTQDGDMIFLSENISKFMGLTQVELT--GHSIFDFT 135
Query: 124 DPADHLTVRQQLTLPSA---------LDTDRLFRCRF-----NTSKSLRRQSAGNKLVLI 169
P DH +R+ L+L + + T+R F R N +++ +SA K++
Sbjct: 136 HPCDHEEIRENLSLKNGSGFGKKSKDMSTERDFFMRMKCTVTNRGRTVNLKSATWKVLHC 195
Query: 170 RGRFHAH---PPGAYWAG--NPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKD 224
G+ + PP G P+ + EP P P + FL SRH+ D
Sbjct: 196 TGQVKVYNNCPPHNSLCGYKEPLLSCLIIMCEPIQHPSHMDIPLDSKTFL----SRHSMD 251
Query: 225 LALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRL 284
+ + + +G+ ELL +S Y H D + + H L + + + R+
Sbjct: 252 MKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSENMTKSHQNLCTKGQVVSGQ--YRM 309
Query: 285 QAKTGGWAWIY---CLLYSEGPEGP--ITANNYPISDME 318
AK GG+ W+ ++Y+ P I NY +S++E
Sbjct: 310 LAKHGGYVWLETQGTVIYNPRNLQPQCIMCVNYVLSEIE 348
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 86.7 bits (213), Expect = 8e-17
Identities = 109/416 (26%), Positives = 169/416 (40%), Gaps = 51/416 (12%)
Query: 34 KVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGK 93
++ +SYL + L C AGG PL + AL GF++V TAEG
Sbjct: 2 RLTISYLRMHRL-CAAGEWNQVGAGGEPLDAC-----------YLKALEGFVMVLTAEGD 49
Query: 94 LLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTLPSALD-------TDRL 146
+ YLSE+VS+HLG S ++L+ G SI+D I P D ++ LT L T+R
Sbjct: 50 MAYLSENVSKHLGLSQLELI--GHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTERC 107
Query: 147 FRCRFNTS-----KSLRRQSAGNKLVLIRGRFHAHPPGAYW--AGNPVFTAFCAPLEPRP 199
F R ++ ++L ++A K++ G A+ P A AG+P L
Sbjct: 108 FSLRMKSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQCLVLIC 167
Query: 200 RPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDL 259
P PG L F SRH+ D+ + + G+ +L+ S Y +H D
Sbjct: 168 EAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDDRIAEVAGYSPDDLIGCSAYEYIHALDS 227
Query: 260 AHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYC-LLYSEGPEGP----ITANNYPI 314
S + LL++ + + R A++GG+ W G GP I ++ I
Sbjct: 228 DAVSKSIHTLLSKGQAVTGQ--YRFLARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLI 285
Query: 315 SDMEAWSLRQQLNSEDTQAAYVL--GTPTMLPSFPENILSQEECSSTNPLFTAALGAPRS 372
S +E + L + + + G P SQ++ + NP + PR
Sbjct: 286 SQVEETGVVLSLEQTEQHSRRPIQRGAP-----------SQKD--TPNPGDSLDTPGPRI 332
Query: 373 TSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTP 428
+F P LS + + + PR D L P S+ A S L P +P
Sbjct: 333 LAFLHPPSLSEAALAAD-PRRFCSPDLRRLLGPILDGASVAATPSTPLATRHPQSP 387
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 85.9 bits (211), Expect = 1e-16
Identities = 93/393 (23%), Positives = 152/393 (38%), Gaps = 82/393 (20%)
Query: 9 SKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFA----------- 57
SK RD++N E+ L LLP + +L L ++ L+ Y R FF
Sbjct: 36 SKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERN 95
Query: 58 GGTPLAGPTGL---LSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVA 114
GG L+ QE E ++ AL GF+LV T + + Y S ++ ++LG D++
Sbjct: 96 GGQDNCRAANFREGLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIH 155
Query: 115 QGDSIYDIIDPADHLTVRQQL--------------------TLPSAL---DTDRL----- 146
Q S+Y++I D ++QL LP + + D++
Sbjct: 156 Q--SVYELIHTEDRAEFQRQLHWALNPSQCTESGQGIEEATGLPQTVVCYNPDQIPPENS 213
Query: 147 ----------FRCRFNTSKSLRRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLE 196
RC + S + KL + G+ G+ A PL+
Sbjct: 214 PLMERCFICRLRCLLDNSSGFLAMNFQGKLKYLHGQKKKGKDGSILPPQLALFAIATPLQ 273
Query: 197 PRPRPGPGPGPGPASLFLA----MFQSRHAKDLALLDISESVLIYLGFERSELLCK-SWY 251
P P+ L + +F+++H D + I LG+ +EL + S Y
Sbjct: 274 P-----------PSILEIRTKNFIFRTKHKLDFTPIGCDAKGRIVLGYTEAELCTRGSGY 322
Query: 252 GLLHPEDLAHASAQHYRLL--AESGDIQAEMVVRLQAKTGGWAWIYC---LLYSEGPEGP 306
+H D+ + + H R++ ESG I V RL K W W+ LLY G
Sbjct: 323 QFIHAADMLYCAESHIRMIKTGESGMI----VFRLLTKNNRWTWVQSNARLLYKNGRPDY 378
Query: 307 ITANNYPISDMEAWSLRQQLNSEDTQAAYVLGT 339
I P++D E + L +T+ ++ T
Sbjct: 379 IIVTQRPLTDEEG---TEHLRKRNTKLPFMFTT 408
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 77.8 bits (190), Expect = 4e-14
Identities = 107/465 (23%), Positives = 164/465 (35%), Gaps = 94/465 (20%)
Query: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTP--- 61
++ A+++RR + N E L +LLPL A +L I+ L Y + F G P
Sbjct: 26 SRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWN 85
Query: 62 --LAGP---TGLLSAQELED----------------IVAALPGFLLVFTAEGKLLYLSES 100
+ GP T + AQ I+ +L GF+ EGK LY+SE+
Sbjct: 86 LRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSHILQSLDGFVFALNQEGKFLYISET 145
Query: 101 VSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQL------------------------- 135
VS +LG S V+L G S++D + P DH+ + +QL
Sbjct: 146 VSIYLGLSQVELT--GSSVFDYVHPGDHVEMAEQLGMKLPPGRGLLSQGTAEDGASSASS 203
Query: 136 ------------TLPSALDTD----RLFRCRFN---TSKSLRRQSAGNKLVLIRGRFHAH 176
T PS L TD R F R T + + +S+G K++ I GR
Sbjct: 204 SSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGVHIKSSGYKVIHITGRLRLR 263
Query: 177 PPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMFQSRHAKDLALLDISESVLI 236
++ P + L P P + MF +R DL ++ +
Sbjct: 264 VSLSHGRTVP---SQIMGLVVVAHALPPPTINEVRIDCHMFVTRVNMDLNIIYCENRISD 320
Query: 237 YLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWI-- 294
Y+ +++ K Y +H ED+ H LL + + R K GG+ WI
Sbjct: 321 YMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV--TKYYRWMQKNGGYIWIQS 378
Query: 295 ---YCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENIL 351
+ E I NY +S+ E + LP PE
Sbjct: 379 SATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDI--------------AQLPHLPEKTS 424
Query: 352 SQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKE 396
E S + G + E S + E P P ++
Sbjct: 425 ESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPEPDRK 469
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 70.1 bits (170), Expect = 8e-12
Identities = 105/484 (21%), Positives = 164/484 (33%), Gaps = 113/484 (23%)
Query: 5 TKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTP--- 61
++ A+++RR + N E L +LLPL A +L I+ L Y + F G P
Sbjct: 26 SRDAARSRRGKENFEFYELAKLLPLPAAITSQLDKASIIRLTISYLKMRDFANQGDPPWN 85
Query: 62 --LAGPTGLLSAQELE--------------------------------------DIVAAL 81
+ GP S + ++ I+ +L
Sbjct: 86 LRMEGPPPNTSVKGIQMWKSELCMRKTPCEVIGAQRRRSPSALAIEVFEAHLGSHILQSL 145
Query: 82 PGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQL------ 135
GF+ EGK LY+SE+VS +LG S V+L G S++D + P DH+ + +QL
Sbjct: 146 DGFVFALNQEGKFLYISETVSIYLGLSQVELT--GSSVFDYVHPGDHVEMAEQLGMKLPP 203
Query: 136 -------------------------------TLPSALDTD----RLFRCRFN---TSKSL 157
T PS L TD R F R T + +
Sbjct: 204 GRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTKRGV 263
Query: 158 RRQSAGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPASLFLAMF 217
+S+G K++ I GR ++ P + L P P + MF
Sbjct: 264 HIKSSGYKVIHITGRLRLRVSLSHGRTVP---SQIMGLVVVAHALPPPTINEVRIDCHMF 320
Query: 218 QSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQ 277
+R DL ++ + Y+ +++ K Y +H ED+ H LL + +
Sbjct: 321 VTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHAEDVEGIRHSHLDLLNKGQCV- 379
Query: 278 AEMVVRLQAKTGGWAWI-----YCLLYSEGPEGPITANNYPISDMEAWSLRQQLNSEDTQ 332
R K GG+ WI + E I NY +S+ E +
Sbjct: 380 -TKYYRWMQKNGGYIWIQSSATIAINAKNANEKNIIWVNYLLSNPEYKDTPMDI------ 432
Query: 333 AAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPR 392
LP PE E S + G + E S + E P
Sbjct: 433 --------AQLPHLPEKTSESSETSDSESDSKDTSGITEDNENSKSDEKGNQSENSEDPE 484
Query: 393 PSKE 396
P ++
Sbjct: 485 PDRK 488
>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
Length = 719
Score = 59.3 bits (142), Expect = 1e-08
Identities = 44/141 (31%), Positives = 69/141 (48%), Gaps = 16/141 (11%)
Query: 9 SKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFF-----------A 57
SK RD++NAE+ +L LLP +L L ++ L+ Y R FF A
Sbjct: 37 SKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPA 96
Query: 58 GGTPLAGPTGLLSAQELED---IVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVA 114
G P G + L+ + + ++ +L GF LV +AEG + Y S ++ ++LG D++
Sbjct: 97 AGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMH 156
Query: 115 QGDSIYDIIDPADHLTVRQQL 135
Q +IYD I D +QL
Sbjct: 157 Q--NIYDYIHVDDRQDFCRQL 175
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/141 (33%), Positives = 74/141 (52%), Gaps = 7/141 (4%)
Query: 10 KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIY--TRKGVFFAGGTPLAGPTG 67
K RRD++N+ I L L+P A +L L ++ +A + T +G PT
Sbjct: 39 KRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPT- 97
Query: 68 LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
LS EL+ ++ A GFL V + GK+L++SESV + L +S DL+ G S++D + P
Sbjct: 98 FLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI--GQSLFDYLHP 155
Query: 126 ADHLTVRQQLTLPSALDTDRL 146
D V++QL+ +RL
Sbjct: 156 KDIAKVKEQLSSSDTAPRERL 176
Score = 33.9 bits (76), Expect = 0.61
Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 6/63 (9%)
Query: 227 LLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQA 286
+L +SESV L + +++L+ +S + LHP+D+A Q L+ S E ++ A
Sbjct: 126 ILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQ----LSSSDTAPRERLI--DA 179
Query: 287 KTG 289
KTG
Sbjct: 180 KTG 182
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/141 (33%), Positives = 74/141 (52%), Gaps = 7/141 (4%)
Query: 10 KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIY--TRKGVFFAGGTPLAGPTG 67
K RRD++N+ I L L+P A +L L ++ +A + T +G PT
Sbjct: 82 KRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPT- 140
Query: 68 LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
LS EL+ ++ A GFL V + GK+L++SESV + L +S DL+ G S++D + P
Sbjct: 141 FLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI--GQSLFDYLHP 198
Query: 126 ADHLTVRQQLTLPSALDTDRL 146
D V++QL+ +RL
Sbjct: 199 KDIAKVKEQLSSSDTAPRERL 219
Score = 33.9 bits (76), Expect = 0.61
Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 6/63 (9%)
Query: 227 LLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQA 286
+L +SESV L + +++L+ +S + LHP+D+A Q L+ S E ++ A
Sbjct: 169 ILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQ----LSSSDTAPRERLI--DA 222
Query: 287 KTG 289
KTG
Sbjct: 223 KTG 225
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 58.5 bits (140), Expect = 2e-08
Identities = 47/141 (33%), Positives = 74/141 (52%), Gaps = 7/141 (4%)
Query: 10 KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIY--TRKGVFFAGGTPLAGPTG 67
K RRD++N+ I L L+P A +L L ++ +A + T +G PT
Sbjct: 82 KRRRDKMNSFIDELASLVPTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEANYKPT- 140
Query: 68 LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
LS EL+ ++ A GFL V + GK+L++SESV + L +S DL+ G S++D + P
Sbjct: 141 FLSDDELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQNDLI--GQSLFDYLHP 198
Query: 126 ADHLTVRQQLTLPSALDTDRL 146
D V++QL+ +RL
Sbjct: 199 KDIAKVKEQLSSSDTAPRERL 219
Score = 33.9 bits (76), Expect = 0.61
Identities = 21/63 (33%), Positives = 35/63 (55%), Gaps = 6/63 (9%)
Query: 227 LLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQA 286
+L +SESV L + +++L+ +S + LHP+D+A Q L+ S E ++ A
Sbjct: 169 ILFVSESVFKILNYSQNDLIGQSLFDYLHPKDIAKVKEQ----LSSSDTAPRERLI--DA 222
Query: 287 KTG 289
KTG
Sbjct: 223 KTG 225
>gi|222352122 hypothetical protein LOC284297 [Homo sapiens]
Length = 1573
Score = 56.2 bits (134), Expect = 1e-07
Identities = 91/432 (21%), Positives = 150/432 (34%), Gaps = 68/432 (15%)
Query: 339 TPTMLPSFPENILSQ----EECSSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPS 394
+PT LP+ P+ + S E +S +P + + + P S VS P PS
Sbjct: 1087 SPTPLPTLPKELTSDPSTPSEVTSLSPTSEQVPESDTTPDLDTTPYSSTVSEYSRSPDPS 1146
Query: 395 KELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSST 454
+ + P+P++ + L P TPH P P T P P++
Sbjct: 1147 PSPHPT-----TTPDPTMAPDPITTL--NPTVTPHFPT---------TPHPTTTPHPTTI 1190
Query: 455 LQEQLTPSTATFSDQLTP--SSATFPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQL 512
+ P T T S PDP T+P + + + P T+ P +
Sbjct: 1191 THSTMIPDPTTTPQPFTTITHSTMIPDPTTTPQPFTTMQPTTTPHSTTPHPTTTPHPTTI 1250
Query: 513 LPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYE 572
ST P+P +P P+T + P+ T +P+PT T + +
Sbjct: 1251 THSTM-IPDPTTTPQPFTTMQPTT-----MPHPTTTPHPTTTPHPTTT---PHPTTTPHP 1301
Query: 573 KLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEI 632
+ P P++ T P + P P+ TP + V +E +
Sbjct: 1302 TMTPDPTTTPYPTTT-------PDPTTTPHPTTPDPSSTPVITTVSLPTSLGTELSSPTL 1354
Query: 633 DRLIQQI--SQLAQGMDRPFSAEAGTGGLEPLGGLEPLDSNLSLSGAGPPVLSLDLKPWK 690
++ QL P ++ + LEP LE S S + + P+ + D KP +
Sbjct: 1355 APTVKPSLHPQLTFTAPAPHTSTSQIPTLEPSPALESSPSRSSTATSMDPLSTEDFKPPR 1414
Query: 691 CQE--------------LDFLADPDNMF------LEETPVEDIFMDLSTPDPSEEWGSGD 730
Q D PD + L+ P++ + + P P +
Sbjct: 1415 SQSPNLTPPPTHTPHSASDLTVSPDPLLSPTAHPLDHPPLDPLTLG---PTPGQ-----S 1466
Query: 731 PEAEGPGGAPSP 742
P GP AP+P
Sbjct: 1467 PGPHGPCVAPTP 1478
Score = 47.0 bits (110), Expect = 7e-05
Identities = 61/225 (27%), Positives = 99/225 (44%), Gaps = 29/225 (12%)
Query: 370 PRSTSFPSAPELSVVSASEELPRP---SKELDFSYLTFPSGPEPSLQAELSKDLVCTPP- 425
P ++ P P L+ S+ E P S+ + T P P+P+ + + DL+ T P
Sbjct: 1011 PSASPGPPGPALTSDSSRELTPHSALTSEATSDAPDTSPPTPDPA--SRTNPDLILTSPD 1068
Query: 426 YTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLT--PSTATFSDQLTPSSA------TF 477
+ P EP PTP TL ++LT PST + L+P+S T
Sbjct: 1069 FALSTPDSSVVPALTPEPS----PTPLPTLPKELTSDPSTPSEVTSLSPTSEQVPESDTT 1124
Query: 478 PDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTP--PS 535
PD T+P ++E S RS + +P +T PD P+ A P+P+ + + +TP P+
Sbjct: 1125 PDLDTTPYSSTVSEYS-RSPDPSPSPHPTTTPD---PTMA--PDPI-TTLNPTVTPHFPT 1177
Query: 536 TAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSS 580
T P+ + P+PT T Q + + + P P++
Sbjct: 1178 TPHPTTTPHPTTITHSTMIPDPTTT--PQPFTTITHSTMIPDPTT 1220
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 54.7 bits (130), Expect = 3e-07
Identities = 77/346 (22%), Positives = 134/346 (38%), Gaps = 66/346 (19%)
Query: 10 KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGP--TG 67
+ RR+++ A I L +++P A + L I+ +A + K + G T G
Sbjct: 84 RRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHM-KSLRGTGNTSTDGSYKPS 142
Query: 68 LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
L+ QEL+ ++ A GFL + + E G+++Y+S+SV+ L + G ++YD + P
Sbjct: 143 FLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF--GSTLYDQVHP 200
Query: 126 ADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAG---------------------- 163
D +R+QL+ T R+ + T K +QS+
Sbjct: 201 DDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVD 260
Query: 164 ----NKLVLIRGRFHAHPPGAYWAGNPVF-----TAFCAPLEPR----PRPGPGPGPGPA 210
N+L +R R + G+ G P F T + P P P G G
Sbjct: 261 PVSVNRLSFVRNRCR-NGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSK 319
Query: 211 SLFLAM----------------------FQSRHAKDLALLDISESVLIYLGFERSELLCK 248
+A+ F SRH + + + +G++ ELL K
Sbjct: 320 FCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGK 379
Query: 249 SWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWI 294
+ HPED +++ G + + M R ++K W W+
Sbjct: 380 NIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVM-FRFRSKNQEWLWM 424
>gi|4502231 aryl hydrocarbon receptor nuclear translocator isoform 1
[Homo sapiens]
Length = 789
Score = 54.7 bits (130), Expect = 3e-07
Identities = 77/346 (22%), Positives = 134/346 (38%), Gaps = 66/346 (19%)
Query: 10 KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGP--TG 67
+ RR+++ A I L +++P A + L I+ +A + K + G T G
Sbjct: 99 RRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHM-KSLRGTGNTSTDGSYKPS 157
Query: 68 LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
L+ QEL+ ++ A GFL + + E G+++Y+S+SV+ L + G ++YD + P
Sbjct: 158 FLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF--GSTLYDQVHP 215
Query: 126 ADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAG---------------------- 163
D +R+QL+ T R+ + T K +QS+
Sbjct: 216 DDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVD 275
Query: 164 ----NKLVLIRGRFHAHPPGAYWAGNPVF-----TAFCAPLEPR----PRPGPGPGPGPA 210
N+L +R R + G+ G P F T + P P P G G
Sbjct: 276 PVSVNRLSFVRNRCR-NGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSK 334
Query: 211 SLFLAM----------------------FQSRHAKDLALLDISESVLIYLGFERSELLCK 248
+A+ F SRH + + + +G++ ELL K
Sbjct: 335 FCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGK 394
Query: 249 SWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWI 294
+ HPED +++ G + + M R ++K W W+
Sbjct: 395 NIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVM-FRFRSKNQEWLWM 439
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 53.9 bits (128), Expect = 6e-07
Identities = 87/330 (26%), Positives = 115/330 (34%), Gaps = 60/330 (18%)
Query: 343 LPSFPENILSQEECSSTNPLFTA--------------ALGAPRSTSFPSAPELSVVSASE 388
LPS P SQ S T P A +L +P + PS LS + A+
Sbjct: 357 LPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATT 416
Query: 389 ELPRPSKELDFSYLTF-----------PSGP------EPSLQAELSKDLVCTPPYTPHQP 431
L P+ + S+LT PS P P LQA LS P P Q
Sbjct: 417 SLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLS-----LPASPPLQT 471
Query: 432 GGCAFLFSLHEPFQTH---------LPTPSSTLQEQLTPSTATFSDQLTPSSATFPDPLT 482
+ L P H +P + L + P T S PS T P LT
Sbjct: 472 SLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLT 531
Query: 483 S-PLQG---------QLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLT 532
+ PL+ Q + + + PC + P Q PS T P P T
Sbjct: 532 TPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPP--ETPSSIAT 589
Query: 533 PPSTAFQAHLDSPSQTFPE-QLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLAL 591
PP A A P Q P LSP T A + + PPSP P + + LA
Sbjct: 590 PPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSP--PASPPLSPLAT 647
Query: 592 AQLRGPLSVDVPLVPEGLLTPEASPVKQSF 621
+ P ++ V L+ P + PV+ F
Sbjct: 648 PSPQAPNALAVHLLQAPFSPPPSPPVQAPF 677
Score = 42.4 bits (98), Expect = 0.002
Identities = 76/291 (26%), Positives = 100/291 (34%), Gaps = 35/291 (12%)
Query: 338 GTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFP-----SAPELSVVSASEELPR 392
GTP P+ P SQ + L + PR + P S+ L+ S S R
Sbjct: 261 GTPRA-PAHP----SQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKAR 315
Query: 393 PSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPS 452
P D + P+ PS L+ L PP +P P P LP+P
Sbjct: 316 PVPPPDNAATPLPATLPPS--PPLATPLPLAPP-SPSAP-----------PSLQTLPSPP 361
Query: 453 STLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYEDQLT----PCTSTF 508
+T Q PS T Q PS T P P+ P LT S+++ L T++
Sbjct: 362 ATPPSQAPPSMTTPPMQAPPSLQTIP-PIQVP--HSLTSPSLQAPPSPLALSSLQATTSL 418
Query: 509 PDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCS 568
L +T +F LT PS DSP P L +P S
Sbjct: 419 GSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVS 478
Query: 569 FLYEKLPPSP----SSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEAS 615
L L P SS + + + PL L P L TP AS
Sbjct: 479 PLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPAS 529
Score = 38.9 bits (89), Expect = 0.019
Identities = 68/266 (25%), Positives = 90/266 (33%), Gaps = 32/266 (12%)
Query: 361 PLFTAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDL 420
P AL +P PS P LS ++ P P + + P P LS
Sbjct: 592 PQAPPALASPPLQGLPSPP-LSPLAT----PPPQAPPXLALPPLQAPPSPPASPPLSP-- 644
Query: 421 VCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTP-STATFSDQLTPSSATFPD 479
+ TP +P P A + L PF P PS +Q +P ++ S TP S P
Sbjct: 645 LATP--SPQAPNALA-VHLLQAPFS---PPPSPPVQAPFSPPASPPVSPSATPPSQAPPS 698
Query: 480 PLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQ 539
PLQ + + TP P P P P SP P
Sbjct: 699 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVP 758
Query: 540 AHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLAL-------- 591
L +P P Q+ P+P A S L + PP + P L AL
Sbjct: 759 PLLAAP----PLQVPPSPP----ASLPMSPLAK--PPPQAPPALATPPLQALPSPPASFP 808
Query: 592 AQLRGPLSVDVPLVPEGLLTPEASPV 617
Q S +P+ P P+A PV
Sbjct: 809 GQAPFSPSASLPMSPLATPPPQAPPV 834
Score = 33.1 bits (74), Expect = 1.0
Identities = 44/168 (26%), Positives = 57/168 (33%), Gaps = 10/168 (5%)
Query: 369 APRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTP 428
+P +T P P L + P P L S L P P A + +PP +
Sbjct: 748 SPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPAS- 806
Query: 429 HQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPS---SATFPDPLTSPL 485
PG F S P +P +T Q P A Q+ PS S T P P
Sbjct: 807 -FPGQAPFSPSASLPM-----SPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPT 860
Query: 486 QGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTP 533
G T S L P P + ST + P+ G + TP
Sbjct: 861 PGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 908
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 53.5 bits (127), Expect = 8e-07
Identities = 122/538 (22%), Positives = 191/538 (35%), Gaps = 115/538 (21%)
Query: 4 STKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLA 63
S + K RRDQ N I+ L +LP A K+ S + S+ + K +
Sbjct: 38 SRNKSEKKRRDQFNVLIKELGSMLP-GNARKMDKSTVLQKSIDFLRKHKEITAQSDASEI 96
Query: 64 G----PTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSI 119
PT L + + + ++ AL GF L +G ++Y+SESV+ L H DLV Q SI
Sbjct: 97 RQDWKPTFLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHLPSDLVDQ--SI 154
Query: 120 YDIIDPADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSAGNKLV----LIRGRFHA 175
++ I +H V + L+ L++D L T + L+ + N+L ++RG
Sbjct: 155 FNFIPEGEHSEVYKILS-THLLESDSL------TPEYLKSK---NQLEFCCHMLRGTIDP 204
Query: 176 HPPGAY----WAGN---------PVFTAFCAPLEPRPRPG-PGPGPGPASLFLAM----- 216
P Y + GN F ++ RP A++ LA
Sbjct: 205 KEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYEDRVCFVATVRLATPQFIK 264
Query: 217 -----------FQSRHAKDLALLDISESVLIYLGFERSELLCKSWYGLLHPEDLAHASAQ 265
F SRH+ + L + +G+ E+L S Y H +DL + +
Sbjct: 265 EMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLENLAKC 324
Query: 266 HYRLLAESGDIQAEMVVRLQAKTGGWAWI---YCLLYSEGPEGP--ITANNYPISDMEAW 320
H L+ R K W W+ Y + Y + P I + +S E
Sbjct: 325 HEHLMQYGKG--KSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVR 382
Query: 321 SLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTNPLFTAALGAPRSTSFPSAPE 380
+ R++ LG LP A +S S
Sbjct: 383 AERRR----------ELGIEESLPE---------------------TAADKSQDSGSDNR 411
Query: 381 LSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSK----DLVCTPPYTPHQPGGCAF 436
++ VS E L R F P PS + S+ V P TP +
Sbjct: 412 INTVSLKEALER-----------FDHSPTPSASSRSSRKSSHTAVSDPSSTPTK-----I 455
Query: 437 LFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQLTETSV 494
P + HLP +Q + + S+ + + Q SS LT P+ Q T +
Sbjct: 456 PTDTSTPPRQHLPAHEKMVQRRSSFSSQSINSQSVGSS------LTQPVMSQATNLPI 507
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 52.8 bits (125), Expect = 1e-06
Identities = 70/278 (25%), Positives = 107/278 (38%), Gaps = 50/278 (17%)
Query: 361 PLFTAALGAPRSTSFPSAPELSVVS--ASEELPRPSK-ELDFSYLTFPSGPEPSLQAELS 417
P +A G P + S P L V+ + +E P P + S P+ P P L
Sbjct: 1447 PATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLP 1506
Query: 418 KDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATF 477
+ +P P P S +P P++TL + TP+T + L P + T
Sbjct: 1507 AVIPSSPKEVPATPS------SRRDPI-----APTATLLSKKTPATLAPKEALIPPAMTV 1555
Query: 478 PDP-----LTSPLQGQLTETSVR-SYEDQLTPCT---STFPDQLL-PSTATFPEPLGSPA 527
P P + +P + T +S S +TP T + P +LL P T P P +P
Sbjct: 1556 PSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKEAPT 1615
Query: 528 HEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCT 587
+TPPS P+ P+ +P T L SP+SP + C
Sbjct: 1616 PPAVTPPSPE-----KGPATPAPKGTPTSPPVT----------PSSLKDSPTSPASVTCK 1660
Query: 588 LLA--------LAQLRGPLSVDVPLVPEGLLTPEASPV 617
+ A L +GP ++ LV PE++P+
Sbjct: 1661 MGATVPQASKGLPAKKGPTALKEVLVAP---APESTPI 1695
Score = 46.6 bits (109), Expect = 9e-05
Identities = 67/264 (25%), Positives = 88/264 (33%), Gaps = 19/264 (7%)
Query: 357 SSTNPLFTAALGAPRSTSFPSAPELSVVSASEELPRPS-KELDFSYLTFPSGPEPSLQAE 415
++T P L P P+ P + S L PS K + P P+ L
Sbjct: 1176 AATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATP 1235
Query: 416 LSKDLVCTPPYTPHQP-GGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSS 474
K TP TP P GG A P PTP + L AT + P+
Sbjct: 1236 SPKGAPTTPAATPPSPKGGPA------TPPPKGAPTPPAATPPSLKGGLATPPHKGAPNP 1289
Query: 475 ATFPDP------LTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAH 528
A P TSP +G T + + +P T P T P P G+P
Sbjct: 1290 AVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTL 1349
Query: 529 EQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTL 588
TP S S P P T ++ + K P+ SP GD T
Sbjct: 1350 PATTPSSKGGPTTPSSKEGPTP----PAATPSHKGGPAMTPPSPKRGPAIPSP-KGDPTS 1404
Query: 589 LALAQLRGPLSVDVPLVPEGLLTP 612
A+ L + P+ EG TP
Sbjct: 1405 PAVIPLSPKKAPATPVTREGAATP 1428
Score = 39.7 bits (91), Expect = 0.011
Identities = 83/327 (25%), Positives = 114/327 (34%), Gaps = 71/327 (21%)
Query: 300 SEGPEGPITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSST 359
S GP+ PI + P+S +EA L + NS Q + T P+ P + S+
Sbjct: 814 SAGPDTPIGNLSSPVSPVEASFLPE--NSLSFQGSKDSPATTHSPT-PPSPKGAPTPSAV 870
Query: 360 NPLFTAALGAP-RSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSK 418
PL + P + T PS L P P + S + S P+ + K
Sbjct: 871 TPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTS--SSPKKARATPAPK 928
Query: 419 DLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTATFSDQL--TPSSAT 476
+ +P P G PTP + AT S + TP +AT
Sbjct: 929 GIPASP-----SPKGA--------------PTPPAATPPSPKGGPATPSPKWAPTPPAAT 969
Query: 477 FPDPLTSPLQGQLTETSVRSYEDQLTPCTSTFPDQLL-PSTATFPEPLGSPAHEQLTPPS 535
P P P + S + TP +T P P+T P P G+P +TPPS
Sbjct: 970 PPSPKGGP--------ATPSPKGAPTPPAATPPSPKGGPAT---PSPKGAPTPPAVTPPS 1018
Query: 536 TAFQAHLDSPSQT-FPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQL 594
SP+ T FP+ S P T PPSP G+ T
Sbjct: 1019 PK-----GSPAATPFPKGASTPPAAT--------------PPSPK--GSPAAT------- 1050
Query: 595 RGPLSVDVPLVPEGLL-TPEASPVKQS 620
PL P P L +P+ P S
Sbjct: 1051 --PLPKGAPTTPAATLPSPKGGPATPS 1075
Score = 37.7 bits (86), Expect = 0.043
Identities = 46/178 (25%), Positives = 68/178 (38%), Gaps = 17/178 (9%)
Query: 405 PSGPEPSLQAELSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPTPSSTLQEQLTPSTA 464
P P+ S K P TP P G L + + TPSS +E TP A
Sbjct: 1317 PPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSS--KEGPTPPAA 1374
Query: 465 TFSDQLTPSSATFPDPLTSPLQGQLTETSVRSYE-DQLTPCTSTFPDQLLPSTATFPEPL 523
T S + P+ T P P P ++ S + D +P + P+T E
Sbjct: 1375 TPSHKGGPAM-TPPSPKRGP--------AIPSPKGDPTSPAVIPLSPKKAPATPVTREGA 1425
Query: 524 GSPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSP 581
+P+ LTPP+ + +P+ + P+ P + +G L PPSP P
Sbjct: 1426 ATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATP-----SSKGDPTLPAVTPPSPKEP 1478
Score = 33.5 bits (75), Expect = 0.80
Identities = 50/193 (25%), Positives = 60/193 (31%), Gaps = 22/193 (11%)
Query: 405 PSGPEPSLQAELSKDLVCTPPYTPHQP-GGCAFLFSLHEPFQTHLPTPSSTLQEQLTPST 463
P P+ K P TP P GG A P + PS TP
Sbjct: 970 PPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFP 1029
Query: 464 ATFSDQLTPSSATFPDPLTSPL-----QGQLTETSVRSYEDQLTPCTSTFPDQLLPSTAT 518
S TP +AT P P SP +G T + + P T + P AT
Sbjct: 1030 KGAS---TPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAAT 1086
Query: 519 FPEPLGSPAHEQ---------LTPPS----TAFQAHLDSPSQTFPEQLSPNPTKTYFAQE 565
P P G PA TPPS A H +P+ SP +
Sbjct: 1087 PPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPK 1146
Query: 566 GCSFLYEKLPPSP 578
G PPSP
Sbjct: 1147 GAPTTPAATPPSP 1159
>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 50.4 bits (119), Expect = 6e-06
Identities = 78/380 (20%), Positives = 138/380 (36%), Gaps = 68/380 (17%)
Query: 370 PRSTSFPSAPELSVVSASEELPRPS-KELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTP 428
P+ P APE ++ S E+LP+ S K + P +Q +L P
Sbjct: 47 PKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLG-----NIPKAS 101
Query: 429 HQPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQ- 486
+P +P + +P P T+Q + + + + P P P+Q
Sbjct: 102 VKPS---------QPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQP 152
Query: 487 --GQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQL--TPPSTAFQAHL 542
G + +TSV+ + + + + + + P P+ P +L P ++
Sbjct: 153 KLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASV----- 207
Query: 543 DSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDV 602
PSQ +S +P + +EG LP S L + P D+
Sbjct: 208 -KPSQPKEGDISKSPEEAIQPKEG------DLPKS-------------LEEAIQPKEGDI 247
Query: 603 PLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE-- 660
P PE + P+ + +S + ++ +I + ++ Q +G D P S E E
Sbjct: 248 PKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKG-DIPKSPEEAIQPKEGD 306
Query: 661 ----PLGGLEPLDSNL--SLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIF 714
P ++P + ++ SL A PP +E+D P+ + +D
Sbjct: 307 IPKSPKQAIQPKEGDIPKSLEEAIPP-----------KEIDIPKSPEETI--QPKEDDSP 353
Query: 715 MDLSTPDPSEEWGSGDPEAE 734
L PS+E PE E
Sbjct: 354 KSLEEATPSKEGDILKPEEE 373
Score = 40.8 bits (94), Expect = 0.005
Identities = 55/289 (19%), Positives = 108/289 (37%), Gaps = 28/289 (9%)
Query: 370 PRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPH 429
P+ P APE ++ S E+LP+ S+E + G P A+ + + T
Sbjct: 107 PKEGDIPKAPEETIQSKKEDLPKSSEEA----IQPKEGDIPKSSAKPIQPKLGNIAKTSV 162
Query: 430 QPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQ 488
+P +P ++ +P +P T+Q + + + + P P P Q +
Sbjct: 163 KPS---------QPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPK 213
Query: 489 LTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQT 548
+ S +S E+ + P P L + + E + P L+ Q
Sbjct: 214 EGDIS-KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQP 272
Query: 549 FPEQLSPNPTKTYFAQEGC------SFLYEK---LPPSPS---SPGNGDCTLLALAQLRG 596
+ +P +T ++G + K +P SP P GD +L +
Sbjct: 273 KEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIP-KSLEEAIP 331
Query: 597 PLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQG 645
P +D+P PE + P+ +S + ++ +I + ++ + +G
Sbjct: 332 PKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEG 380
>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
sapiens]
Length = 553
Score = 50.4 bits (119), Expect = 6e-06
Identities = 78/380 (20%), Positives = 138/380 (36%), Gaps = 68/380 (17%)
Query: 370 PRSTSFPSAPELSVVSASEELPRPS-KELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTP 428
P+ P APE ++ S E+LP+ S K + P +Q +L P
Sbjct: 114 PKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLG-----NIPKAS 168
Query: 429 HQPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQ- 486
+P +P + +P P T+Q + + + + P P P+Q
Sbjct: 169 VKPS---------QPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQP 219
Query: 487 --GQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQL--TPPSTAFQAHL 542
G + +TSV+ + + + + + + P P+ P +L P ++
Sbjct: 220 KLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASV----- 274
Query: 543 DSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDV 602
PSQ +S +P + +EG LP S L + P D+
Sbjct: 275 -KPSQPKEGDISKSPEEAIQPKEG------DLPKS-------------LEEAIQPKEGDI 314
Query: 603 PLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE-- 660
P PE + P+ + +S + ++ +I + ++ Q +G D P S E E
Sbjct: 315 PKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKG-DIPKSPEEAIQPKEGD 373
Query: 661 ----PLGGLEPLDSNL--SLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIF 714
P ++P + ++ SL A PP +E+D P+ + +D
Sbjct: 374 IPKSPKQAIQPKEGDIPKSLEEAIPP-----------KEIDIPKSPEETI--QPKEDDSP 420
Query: 715 MDLSTPDPSEEWGSGDPEAE 734
L PS+E PE E
Sbjct: 421 KSLEEATPSKEGDILKPEEE 440
Score = 40.8 bits (94), Expect = 0.005
Identities = 55/289 (19%), Positives = 108/289 (37%), Gaps = 28/289 (9%)
Query: 370 PRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPH 429
P+ P APE ++ S E+LP+ S+E + G P A+ + + T
Sbjct: 174 PKEGDIPKAPEETIQSKKEDLPKSSEEA----IQPKEGDIPKSSAKPIQPKLGNIAKTSV 229
Query: 430 QPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQ 488
+P +P ++ +P +P T+Q + + + + P P P Q +
Sbjct: 230 KPS---------QPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPK 280
Query: 489 LTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQT 548
+ S +S E+ + P P L + + E + P L+ Q
Sbjct: 281 EGDIS-KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQP 339
Query: 549 FPEQLSPNPTKTYFAQEGC------SFLYEK---LPPSPS---SPGNGDCTLLALAQLRG 596
+ +P +T ++G + K +P SP P GD +L +
Sbjct: 340 KEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIP-KSLEEAIP 398
Query: 597 PLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQG 645
P +D+P PE + P+ +S + ++ +I + ++ + +G
Sbjct: 399 PKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEG 447
>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 50.4 bits (119), Expect = 6e-06
Identities = 78/380 (20%), Positives = 138/380 (36%), Gaps = 68/380 (17%)
Query: 370 PRSTSFPSAPELSVVSASEELPRPS-KELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTP 428
P+ P APE ++ S E+LP+ S K + P +Q +L P
Sbjct: 47 PKEGDIPKAPEETIQSKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLG-----NIPKAS 101
Query: 429 HQPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQ- 486
+P +P + +P P T+Q + + + + P P P+Q
Sbjct: 102 VKPS---------QPKEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQP 152
Query: 487 --GQLTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQL--TPPSTAFQAHL 542
G + +TSV+ + + + + + + P P+ P +L P ++
Sbjct: 153 KLGNIAKTSVKPSQPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASV----- 207
Query: 543 DSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDV 602
PSQ +S +P + +EG LP S L + P D+
Sbjct: 208 -KPSQPKEGDISKSPEEAIQPKEG------DLPKS-------------LEEAIQPKEGDI 247
Query: 603 PLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQGMDRPFSAEAGTGGLE-- 660
P PE + P+ + +S + ++ +I + ++ Q +G D P S E E
Sbjct: 248 PKSPEEAIQPKEGDIPKSLEEAIQPKEGDIPKSPEETIQPKKG-DIPKSPEEAIQPKEGD 306
Query: 661 ----PLGGLEPLDSNL--SLSGAGPPVLSLDLKPWKCQELDFLADPDNMFLEETPVEDIF 714
P ++P + ++ SL A PP +E+D P+ + +D
Sbjct: 307 IPKSPKQAIQPKEGDIPKSLEEAIPP-----------KEIDIPKSPEETI--QPKEDDSP 353
Query: 715 MDLSTPDPSEEWGSGDPEAE 734
L PS+E PE E
Sbjct: 354 KSLEEATPSKEGDILKPEEE 373
Score = 40.8 bits (94), Expect = 0.005
Identities = 55/289 (19%), Positives = 108/289 (37%), Gaps = 28/289 (9%)
Query: 370 PRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCTPPYTPH 429
P+ P APE ++ S E+LP+ S+E + G P A+ + + T
Sbjct: 107 PKEGDIPKAPEETIQSKKEDLPKSSEEA----IQPKEGDIPKSSAKPIQPKLGNIAKTSV 162
Query: 430 QPGGCAFLFSLHEPFQTHLP-TPSSTLQEQLTPSTATFSDQLTPSSATFPDPLTSPLQGQ 488
+P +P ++ +P +P T+Q + + + + P P P Q +
Sbjct: 163 KPS---------QPKESDIPKSPEETIQPKEGDIPKSSAKPIQPKLGNIPKASVKPSQPK 213
Query: 489 LTETSVRSYEDQLTPCTSTFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLDSPSQT 548
+ S +S E+ + P P L + + E + P L+ Q
Sbjct: 214 EGDIS-KSPEEAIQPKEGDLPKSLEEAIQPKEGDIPKSPEEAIQPKEGDIPKSLEEAIQP 272
Query: 549 FPEQLSPNPTKTYFAQEGC------SFLYEK---LPPSPS---SPGNGDCTLLALAQLRG 596
+ +P +T ++G + K +P SP P GD +L +
Sbjct: 273 KEGDIPKSPEETIQPKKGDIPKSPEEAIQPKEGDIPKSPKQAIQPKEGDIP-KSLEEAIP 331
Query: 597 PLSVDVPLVPEGLLTPEASPVKQSFFHYSEKEQNEIDRLIQQISQLAQG 645
P +D+P PE + P+ +S + ++ +I + ++ + +G
Sbjct: 332 PKEIDIPKSPEETIQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEG 380
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 50.1 bits (118), Expect = 8e-06
Identities = 39/130 (30%), Positives = 65/130 (50%), Gaps = 5/130 (3%)
Query: 10 KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTR--KGVFFAGGTPLAGPTG 67
K RRD++N I L ++P +L L ++ +A + R KG+ + P+
Sbjct: 117 KRRRDKMNNLIEELSAMIPQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVGSNYRPSF 176
Query: 68 LLSAQELEDIVAALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPA 126
L + I+ GFL V E GK+L++S+SVS+ L + L G S++D + P
Sbjct: 177 LQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQASLT--GQSLFDFLHPK 234
Query: 127 DHLTVRQQLT 136
D V++QL+
Sbjct: 235 DVAKVKEQLS 244
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 50.1 bits (118), Expect = 8e-06
Identities = 43/157 (27%), Positives = 78/157 (49%), Gaps = 7/157 (4%)
Query: 10 KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGP--TG 67
+ RR+++ A I L +++P A + L I+ +A + K + G T G
Sbjct: 99 RRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHM-KSLRGTGNTSTDGSYKPS 157
Query: 68 LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
L+ QEL+ ++ A GFL + + E G+++Y+S+SV+ L + G ++YD + P
Sbjct: 158 FLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWF--GSTLYDQVHP 215
Query: 126 ADHLTVRQQLTLPSALDTDRLFRCRFNTSKSLRRQSA 162
D +R+QL+ T R+ + T K +QS+
Sbjct: 216 DDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSS 252
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 49.7 bits (117), Expect = 1e-05
Identities = 134/660 (20%), Positives = 227/660 (34%), Gaps = 120/660 (18%)
Query: 10 KARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGP--TG 67
+ RR+++ I L +++P A + L I+ +A + K + G G
Sbjct: 73 RRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHM-KSMRGTGNKSTDGAYKPS 131
Query: 68 LLSAQELEDIVA-ALPGFLLVFTAE-GKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDP 125
L+ QEL+ ++ A GFL V AE G+++Y+S+SV+ L + G ++Y+ + P
Sbjct: 132 FLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWF--GSTLYEQVHP 189
Query: 126 ADHLTVRQQL--------------------------TLPSALDTDRLFRCRFNTSKSLRR 159
D +R+QL ++ + + R F CR +
Sbjct: 190 DDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGNAPLD 249
Query: 160 QSAGNKLVLIRGRFHAHPPGAYWAGNPVF-----TAFCAPLEPR----PRPGPGPGPGPA 210
N++ +R RF + G G + T + P P G G
Sbjct: 250 HLPLNRITTMRKRFR-NGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEEDADVGQGSK 308
Query: 211 SLFLAM----------------------FQSRHAKDLALLDISESVLIYLGFERSELLCK 248
+A+ F SRH D + + + +G++ +LL K
Sbjct: 309 YCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGYQPQDLLGK 368
Query: 249 SWYGLLHPEDLAHASAQHYRLLAESGDIQAEMVVRLQAKTGGWAWIYCLLYS-EGPEGP- 306
HPED +H +++ G + + M R + K W I ++ + P
Sbjct: 369 DILEFCHPEDQSHLRESFQQVVKLKGQVLSVM-YRFRTKNREWMLIRTSSFTFQNPYSDE 427
Query: 307 ---ITANNYPISDMEAWSLRQQLNSEDTQAAYVLGTPTMLPSFPENILSQEECSSTNPLF 363
I N + ++ +++ D ++Y L + +P+ P + E +
Sbjct: 428 IEYIICTNTNVKQLQQQQAELEVHQRDGLSSYDL-SQVPVPNLPAGV---HEAGKSVEKA 483
Query: 364 TAALGAPRSTSFPSAPELSVVSASEELPRPSKELDFSYLTFPSGPEPSLQAELSKDLVCT 423
A R F A + +SASE+ S + + G
Sbjct: 484 DAIFSQERDPRF--AEMFAGISASEKKMMSSASAAGTQQIYSQG---------------- 525
Query: 424 PPYTPHQPGGCAFLFS-LHEPFQTHLPTPSSTLQEQLTPSTATFSDQLTPSSATFPDP-L 481
P+ P G AF S +H P + + SST Q S Q+ + + P P
Sbjct: 526 SPF-PSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVAWTGSRPPFPGQ 584
Query: 482 TSPLQGQLTETS-------------VRSYEDQLTPCTSTFPDQLLPSTAT----FPEPLG 524
P Q T++S SY +P TS+ S A F E
Sbjct: 585 QIPSQSSKTQSSPFGIGTSHTYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQ 644
Query: 525 SPAHEQLTPPSTAFQAHLDSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNG 584
S Q P Q Q EQ S Q G + +++ + P P P G
Sbjct: 645 SSGQFQGRPSEVWSQWQSQHHGQQSGEQHS-------HQQPGQTEVFQDMLPMPGDPTQG 697
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,741,201
Number of Sequences: 37866
Number of extensions: 2301570
Number of successful extensions: 9349
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 234
Number of HSP's that attempted gapping in prelim test: 7880
Number of HSP's gapped (non-prelim): 1073
length of query: 802
length of database: 18,247,518
effective HSP length: 110
effective length of query: 692
effective length of database: 14,082,258
effective search space: 9744922536
effective search space used: 9744922536
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.