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Search of human proteins with 194018553
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194018553 solute carrier family 9 isoform 3 regulator 2
isoform a [Homo sapiens]
(337 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194018553 solute carrier family 9 isoform 3 regulator 2 isofo... 690 0.0
gi|71897229 solute carrier family 9 isoform 3 regulator 2 isofor... 657 0.0
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 327 9e-90
gi|21361142 PDZ domain containing 1 [Homo sapiens] 141 9e-34
gi|21630285 PDZ domain containing 3 [Homo sapiens] 131 1e-30
gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo... 87 2e-17
gi|45827729 scribble isoform b [Homo sapiens] 79 6e-15
gi|45827731 scribble isoform a [Homo sapiens] 79 6e-15
gi|112382257 InaD-like [Homo sapiens] 76 5e-14
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 72 9e-13
gi|31742501 sorting nexin family member 27 [Homo sapiens] 71 2e-12
gi|148746189 multiple PDZ domain protein [Homo sapiens] 70 2e-12
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 70 3e-12
gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo sapi... 69 8e-12
gi|41281808 harmonin isoform b3 [Homo sapiens] 67 2e-11
gi|71480164 harmonin isoform a [Homo sapiens] 67 2e-11
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 67 2e-11
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 67 2e-11
gi|8922944 lin-7 homolog C [Homo sapiens] 64 2e-10
gi|11545920 lin-7 homolog B [Homo sapiens] 64 2e-10
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 63 3e-10
gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 63 3e-10
gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 63 3e-10
gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 63 3e-10
gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 63 3e-10
gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 63 4e-10
gi|87196343 PDZ domain containing 2 [Homo sapiens] 61 1e-09
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 61 2e-09
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 61 2e-09
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 61 2e-09
>gi|194018553 solute carrier family 9 isoform 3 regulator 2 isoform
a [Homo sapiens]
Length = 337
Score = 690 bits (1781), Expect = 0.0
Identities = 337/337 (100%), Positives = 337/337 (100%)
Query: 1 MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN 60
MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN
Sbjct: 1 MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN 60
Query: 61 GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE 120
GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE
Sbjct: 61 GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE 120
Query: 121 PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180
PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD
Sbjct: 121 PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180
Query: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR 240
PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR
Sbjct: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR 240
Query: 241 VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGL 300
VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGL
Sbjct: 241 VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGL 300
Query: 301 HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 337
HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF
Sbjct: 301 HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 337
>gi|71897229 solute carrier family 9 isoform 3 regulator 2 isoform b
[Homo sapiens]
Length = 326
Score = 657 bits (1694), Expect = 0.0
Identities = 326/337 (96%), Positives = 326/337 (96%), Gaps = 11/337 (3%)
Query: 1 MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN 60
MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN
Sbjct: 1 MAAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVN 60
Query: 61 GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE 120
GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE
Sbjct: 61 GVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE 120
Query: 121 PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180
PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD
Sbjct: 121 PKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180
Query: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR 240
PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR
Sbjct: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLR 240
Query: 241 VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGL 300
VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTE ESGL
Sbjct: 241 VTPTEEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTE-----------ESGL 289
Query: 301 HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 337
HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF
Sbjct: 290 HLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSNF 326
>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
Length = 358
Score = 327 bits (838), Expect = 9e-90
Identities = 187/359 (52%), Positives = 225/359 (62%), Gaps = 31/359 (8%)
Query: 2 AAPEPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNG 61
AA PL PRLC L +G GYGFHLHGEKG+ GQ+IR VEPGSPAE A L AGDRLVEVNG
Sbjct: 6 AAGAPL-PRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLVEVNG 64
Query: 62 VNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEM--AQRGLPPAHDPW 119
NVE ETH QVV RI+A RLLVVD ETDE+L++ + EE+ AQ A P
Sbjct: 65 ENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQAEPPA 124
Query: 120 EPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSV 179
+ A + EA K RELRPRLC ++KGP GYGFNLHSDKS+PGQ+IRSV
Sbjct: 125 AAEVQGAGNENEPREADKSHPEQ--RELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIRSV 182
Query: 180 DPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRL 239
DP SPA SGLRAQDR++EVNG +EG +H +VV++I+A DE +LLVVD ETDE FK+
Sbjct: 183 DPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFKKC 242
Query: 240 RVTPTEEHVEGPLPSPVTNG------------------TSPAQLNGGSACSSR----SDL 277
RV P++EH+ GPLP P TNG PA + S+ +S D
Sbjct: 243 RVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQDS 302
Query: 278 PGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARAMRVNKRAPQMDWNRKREIFSN 336
P T S DP + + L A AKE+A R +KRAPQMDW++K E+FSN
Sbjct: 303 PPKQDSTAPSSTSSSDPILDFNISL----AMAKERAHQKRSSKRAPQMDWSKKNELFSN 357
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 141 bits (355), Expect = 9e-34
Identities = 93/287 (32%), Positives = 142/287 (49%), Gaps = 13/287 (4%)
Query: 6 PLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVE 65
P +PR+ + +G GYGF+L ++GQ I+ ++ GSPAE A L+ D +V VNG +VE
Sbjct: 238 PHQPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEEAGLKNNDLVVAVNGESVE 297
Query: 66 GETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDW 125
H VV+ I+ QT LLVVD+ETD R + + LP P P
Sbjct: 298 TLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYYQSQELPNGSVKEAPAPTP 357
Query: 126 AHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPA 185
S ++V + +P+LC L KG GYGF+L++ + PG +I+ V G PA
Sbjct: 358 TSLEVSSPPDTTEEV-----DHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPA 412
Query: 186 ARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTE 245
+GL +D +IEVNG NV + +VV I++ LLV + ++F+ ++ P
Sbjct: 413 DLAGLEDEDVIIEVNGVNVLDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKI-PIV 471
Query: 246 EHVEGPLPSP-------VTNGTSPAQLNGGSACSSRSDLPGSDKDTE 285
+ PL +P V + + A S+ S + +DTE
Sbjct: 472 SSLADPLDTPPDSKEGIVVESNHDSHMAKERAHSTASHSSSNSEDTE 518
Score = 139 bits (349), Expect = 5e-33
Identities = 81/247 (32%), Positives = 124/247 (50%), Gaps = 32/247 (12%)
Query: 8 RPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGE 67
+PRLC LV+ YGF L +G++G ++ + P A A + A D L+EVNG NVE
Sbjct: 132 QPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDA 191
Query: 68 THHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAH 127
+H +VV+++K + L+VD+ETD+ +++ E A L P
Sbjct: 192 SHEEVVEKVKKSGSRVMFLLVDKETDKRHVEQKIQFKRETASLKLLPH------------ 239
Query: 128 TGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAAR 187
+PR+ ++KG GYGF L + + GQ I+ +D GSPA
Sbjct: 240 --------------------QPRIVEMKKGSNGYGFYLRAGSEQKGQIIKDIDSGSPAEE 279
Query: 188 SGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEH 247
+GL+ D ++ VNG++VE L H VV I+ D+ LLVVD ETD ++ +P +
Sbjct: 280 AGLKNNDLVVAVNGESVETLDHDSVVEMIRKGGDQTSLLVVDKETDNMYRLAHFSPFLYY 339
Query: 248 VEGPLPS 254
LP+
Sbjct: 340 QSQELPN 346
Score = 128 bits (322), Expect = 6e-30
Identities = 83/234 (35%), Positives = 116/234 (49%), Gaps = 30/234 (12%)
Query: 9 PRLCRLVRGE-QGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGE 67
PR C+L + E Q YGF L EK G +R VE SPAE A L+ GDR++ +NGV V+ E
Sbjct: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66
Query: 68 THHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAH 127
H QVV ++ LLV+D ++ E+ + ++ D
Sbjct: 67 EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRV----------------------DLKE 104
Query: 128 TGSHSSEAGKKD-VSGPLRE------LRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVD 180
G E G D + P+ +PRLC+L K YGF+L + + + G Y+ +
Sbjct: 105 LGQSQKEQGLSDNILSPVMNGGVQTWTQPRLCYLVKEGGSYGFSLKTVQGKKGVYMTDIT 164
Query: 181 PGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDE 234
P A R+G+ A D LIEVNG+NVE H EVV +K L+VD ETD+
Sbjct: 165 PQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEKVKKSGSRVMFLLVDKETDK 218
Score = 62.4 bits (150), Expect = 6e-10
Identities = 40/119 (33%), Positives = 62/119 (52%), Gaps = 8/119 (6%)
Query: 149 PRLCHLRKGP-QGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
PR C L K Q YGF L +K G +R V+ SPA ++GL+ DR++ +NG V+
Sbjct: 7 PRECKLSKQEGQNYGFFLRIEKDTEGHLVRVVEKCSPAEKAGLQDGDRVLRINGVFVDKE 66
Query: 208 RHAEVVASIKAREDEARLLVVDPETDEHFKRLRV-------TPTEEHVEGPLPSPVTNG 259
H +VV ++ + LLV+D ++ E + RV + E+ + + SPV NG
Sbjct: 67 EHMQVVDLVRKSGNSVTLLVLDGDSYEKAVKTRVDLKELGQSQKEQGLSDNILSPVMNG 125
>gi|21630285 PDZ domain containing 3 [Homo sapiens]
Length = 491
Score = 131 bits (329), Expect = 1e-30
Identities = 97/264 (36%), Positives = 130/264 (49%), Gaps = 56/264 (21%)
Query: 7 LRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
+RPRLC +V+ E G+GF + G +G F + G AE A + G RL+EVNG+ G
Sbjct: 153 VRPRLCHIVKDEGGFGFSV--THGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGLWQSG 210
Query: 67 ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
+ Q LLV E +E+ R Q GLP A E WA
Sbjct: 211 Q--------------QVTLLVAGPEVEEQCR-----------QLGLPLAAPLAE---GWA 242
Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKS---RPGQYIRSVDPGS 183
+PR HL KGPQG+GF L +K RPGQ++ VDPG
Sbjct: 243 ------------------LPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGL 284
Query: 184 PAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
PA ++G++A DRL+ V G++VEGL H E V+ I+ + L VVDPE D F +R++P
Sbjct: 285 PAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSP 344
Query: 244 T--EEHVEGPLPSPVTNGTSPAQL 265
E+ E P SP G+S A L
Sbjct: 345 LLFLENTEAP-ASP--QGSSSASL 365
Score = 119 bits (298), Expect = 4e-27
Identities = 82/219 (37%), Positives = 108/219 (49%), Gaps = 9/219 (4%)
Query: 6 PLRPRLCRLVRGEQGYGFHLHGEKG---RRGQFIRRVEPGSPAEAAALRAGDRLVEVNGV 62
P +PR L +G QG+GF L EKG R GQF+ V+PG PA+ A ++AGDRLV V G
Sbjct: 244 PTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGE 303
Query: 63 NVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPK 122
+VEG H + V RI+ L VVD E D +L+ L P P+
Sbjct: 304 SVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLS-----PLLFLENTEAPASPQ 358
Query: 123 PDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQG-YGFNLHSDKSRPGQYIRSVDP 181
+ + + + +D S P L R C L GP G YGF L S P +I V P
Sbjct: 359 GSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTP 418
Query: 182 GSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKARE 220
G AAR+GL+ D ++EVNG V G E + + E
Sbjct: 419 GGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAE 457
Score = 88.6 bits (218), Expect = 7e-18
Identities = 76/253 (30%), Positives = 110/253 (43%), Gaps = 59/253 (23%)
Query: 8 RPRLCRLVRGE-QGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
RPR C L + E + +GFHL E GR G + RV+PG+ A+ L+ GDR++ VN VE
Sbjct: 46 RPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEH 105
Query: 67 ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
E + VV+RI+A + L V+ + + R AQ G
Sbjct: 106 EDYAVVVRRIRASSPRVLLTVLARHAHDVAR----------AQLG--------------- 140
Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAA 186
+A GP +RPRLCH+ K G+GF++ P + S G A
Sbjct: 141 ------EDAHLCPTLGP--GVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLST--GGAAE 190
Query: 187 RSGLRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEE 246
R+G+ RL+EVNG G + LLV PE +E ++L +
Sbjct: 191 RAGVPPGARLLEVNGLWQSG--------------QQVTLLVAGPEVEEQCRQLGL----- 231
Query: 247 HVEGPLPSPVTNG 259
PL +P+ G
Sbjct: 232 ----PLAAPLAEG 240
>gi|169217736 PREDICTED: similar to PDZ domain containing 1 [Homo
sapiens]
Length = 227
Score = 87.4 bits (215), Expect = 2e-17
Identities = 47/136 (34%), Positives = 73/136 (53%), Gaps = 4/136 (2%)
Query: 5 EPLRPRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNV 64
E +P+LCRL +GE GYGFHL+ +G G FI+ V+ G PA+ A L D ++EVNGVNV
Sbjct: 51 EDHKPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNV 110
Query: 65 EGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPD 124
E + +VV RI++ LLV ++ + + +++ +A P P + K
Sbjct: 111 LDEPYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKIPIVSSLAD----PLDTPPDSKEG 166
Query: 125 WAHTGSHSSEAGKKDV 140
+H S K+ +
Sbjct: 167 IVVESNHDSHMAKERI 182
Score = 73.9 bits (180), Expect = 2e-13
Identities = 39/108 (36%), Positives = 62/108 (57%), Gaps = 1/108 (0%)
Query: 148 RPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
+P+LC L KG GYGF+L++ + PG +I+ V G PA +GL +D +IEVNG NV
Sbjct: 54 KPKLCRLAKGENGYGFHLNAIRGLPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVLDE 113
Query: 208 RHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSP 255
+ +VV I++ LLV + ++F+ ++ P + PL +P
Sbjct: 114 PYEKVVDRIQSSGKNVTLLVCGKKAYDYFQAKKI-PIVSSLADPLDTP 160
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 79.0 bits (193), Expect = 6e-15
Identities = 81/259 (31%), Positives = 105/259 (40%), Gaps = 56/259 (21%)
Query: 3 APEPLRPR-LCRLVRGEQGYGFHLHGEKGRR-------GQFIRRVEPGSPAE-AAALRAG 53
+P PLR R + L R E+G GF + G KG G F+ R+ G A A L+ G
Sbjct: 853 SPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
Query: 54 DRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLP 113
DR++ +NGV+V H V + A LL+ E A LP
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLLTAASPTIALLL-----------------EREAGGPLP 955
Query: 114 PAHDPWEPKPDWAHTGSHSSEAGKKDVSG-----------------PLRELR-PRLCHLR 155
P+ P P A + S V G P+ E+R PR
Sbjct: 956 PSPLP-HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRA---- 1010
Query: 156 KGPQGYGFNLHSDKS-------RPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLR 208
GP G SD S PG +I V P AARSGLR DR++ VNGQ+V
Sbjct: 1011 GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDAT 1070
Query: 209 HAEVVASIKAREDEARLLV 227
H E V+++ E LLV
Sbjct: 1071 HQEAVSALLRPCLELSLLV 1089
Score = 73.6 bits (179), Expect = 2e-13
Identities = 77/283 (27%), Positives = 120/283 (42%), Gaps = 47/283 (16%)
Query: 14 LVRGEQGYGFHLHGEKGR-------RGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
++R G G + G KG G FI RV PA A +R GD+L+EVNGV ++G
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQG 790
Query: 67 ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
HH+ V+ ++ ++ V R R + + L P D + P+
Sbjct: 791 AEHHEAVEALRGAGTAVQMRV--------WRERMVEPENAVTITPLRP-EDDYSPRE--R 839
Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDK-SRP------GQYIRSV 179
G + GPLR+ R C L + +G GF++ K S P G ++ +
Sbjct: 840 RGGGLRLPLLPPESPGPLRQ-RHVAC-LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRI 897
Query: 180 DPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKR 238
G A R+G L+ DR++ +NG +V RH V+ + A LL+
Sbjct: 898 AEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL----------- 946
Query: 239 LRVTPTEEHVEGPL-PSPVTNGTSP-AQLNGGSACSSRSDLPG 279
E GPL PSP+ + + P A + S ++ +PG
Sbjct: 947 ------EREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPG 983
Score = 57.4 bits (137), Expect = 2e-08
Identities = 69/278 (24%), Positives = 100/278 (35%), Gaps = 57/278 (20%)
Query: 33 GQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQET 92
G FI +V P A + LR GDR++ VNG +V TH + V + + LLV
Sbjct: 1035 GVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPA 1094
Query: 93 DEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLC 152
LR C ++ L +
Sbjct: 1095 PPGLRE---LCIQKAPGERLGIS------------------------------------- 1114
Query: 153 HLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAE 211
+R G +G+ N D + G +I V P A R G LR RL+EVN Q++ GL H E
Sbjct: 1115 -IRGGARGHAGNPR-DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172
Query: 212 VVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQLNGGSAC 271
V +++ D +LV D L V+P G + +P G
Sbjct: 1173 AVQLLRSVGDTLTVLVCDGFEASTDAALEVSP------GVIANPFAAGIGHR-------- 1218
Query: 272 SSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEA 309
+S + D++ K+ LH P A EA
Sbjct: 1219 NSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEA 1256
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 79.0 bits (193), Expect = 6e-15
Identities = 81/259 (31%), Positives = 105/259 (40%), Gaps = 56/259 (21%)
Query: 3 APEPLRPR-LCRLVRGEQGYGFHLHGEKGRR-------GQFIRRVEPGSPAE-AAALRAG 53
+P PLR R + L R E+G GF + G KG G F+ R+ G A A L+ G
Sbjct: 853 SPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVG 912
Query: 54 DRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLP 113
DR++ +NGV+V H V + A LL+ E A LP
Sbjct: 913 DRVLSINGVDVTEARHDHAVSLLTAASPTIALLL-----------------EREAGGPLP 955
Query: 114 PAHDPWEPKPDWAHTGSHSSEAGKKDVSG-----------------PLRELR-PRLCHLR 155
P+ P P A + S V G P+ E+R PR
Sbjct: 956 PSPLP-HSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRA---- 1010
Query: 156 KGPQGYGFNLHSDKS-------RPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLR 208
GP G SD S PG +I V P AARSGLR DR++ VNGQ+V
Sbjct: 1011 GGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDAT 1070
Query: 209 HAEVVASIKAREDEARLLV 227
H E V+++ E LLV
Sbjct: 1071 HQEAVSALLRPCLELSLLV 1089
Score = 73.6 bits (179), Expect = 2e-13
Identities = 77/283 (27%), Positives = 120/283 (42%), Gaps = 47/283 (16%)
Query: 14 LVRGEQGYGFHLHGEKGR-------RGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEG 66
++R G G + G KG G FI RV PA A +R GD+L+EVNGV ++G
Sbjct: 731 ILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQG 790
Query: 67 ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
HH+ V+ ++ ++ V R R + + L P D + P+
Sbjct: 791 AEHHEAVEALRGAGTAVQMRV--------WRERMVEPENAVTITPLRP-EDDYSPRE--R 839
Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDK-SRP------GQYIRSV 179
G + GPLR+ R C L + +G GF++ K S P G ++ +
Sbjct: 840 RGGGLRLPLLPPESPGPLRQ-RHVAC-LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRI 897
Query: 180 DPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKR 238
G A R+G L+ DR++ +NG +V RH V+ + A LL+
Sbjct: 898 AEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLL----------- 946
Query: 239 LRVTPTEEHVEGPL-PSPVTNGTSP-AQLNGGSACSSRSDLPG 279
E GPL PSP+ + + P A + S ++ +PG
Sbjct: 947 ------EREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPG 983
Score = 57.4 bits (137), Expect = 2e-08
Identities = 69/278 (24%), Positives = 100/278 (35%), Gaps = 57/278 (20%)
Query: 33 GQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQET 92
G FI +V P A + LR GDR++ VNG +V TH + V + + LLV
Sbjct: 1035 GVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPA 1094
Query: 93 DEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLC 152
LR C ++ L +
Sbjct: 1095 PPGLRE---LCIQKAPGERLGIS------------------------------------- 1114
Query: 153 HLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAE 211
+R G +G+ N D + G +I V P A R G LR RL+EVN Q++ GL H E
Sbjct: 1115 -IRGGARGHAGNPR-DPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGE 1172
Query: 212 VVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQLNGGSAC 271
V +++ D +LV D L V+P G + +P G
Sbjct: 1173 AVQLLRSVGDTLTVLVCDGFEASTDAALEVSP------GVIANPFAAGIGHR-------- 1218
Query: 272 SSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEA 309
+S + D++ K+ LH P A EA
Sbjct: 1219 NSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEA 1256
>gi|112382257 InaD-like [Homo sapiens]
Length = 1801
Score = 75.9 bits (185), Expect = 5e-14
Identities = 71/289 (24%), Positives = 126/289 (43%), Gaps = 28/289 (9%)
Query: 32 RGQFIRRVEPGSPA-EAAALRAGDRLVEVNGVNVEGETHHQVVQRIK-----------AV 79
+G FI++V SPA + AL+ GD+++EV+GV+++ +H + V+ IK ++
Sbjct: 1100 KGIFIKQVLEDSPAGKTNALKTGDKILEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSL 1159
Query: 80 EGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKD 139
R++ ++ Q T+E ++ A P + P + S E ++D
Sbjct: 1160 SSTPRVIPNVHNKANKITGNQNQDTQEKKEKRQGTAPPPMKLPPPYKALTDDSDENEEED 1219
Query: 140 VSGPLRELRPR---------LCHLRKGPQGYGFNL--HSDKSRPGQYIRSVDPGSPAARS 188
+++R R + L K G G +L + D+SR ++ ++P PAA
Sbjct: 1220 AFTD-QKIRQRYADLPGELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAAD 1278
Query: 189 G-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEH 247
G +R D L+E+N Q + G H A IK + +L+ + ++ ++ VTP
Sbjct: 1279 GRMRIGDELLEINNQILYGRSHQNASAIIKTAPSKVKLVFI--RNEDAVNQMAVTPFPVP 1336
Query: 248 VEGPLPSPVTNGTSP-AQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPF 295
P +GT P + GS LP S+ S KQ +
Sbjct: 1337 SSSPSSIEDQSGTEPISSEEDGSVEVGIKQLPESESFKLAVSQMKQQKY 1385
Score = 63.2 bits (152), Expect = 3e-10
Identities = 74/308 (24%), Positives = 128/308 (41%), Gaps = 35/308 (11%)
Query: 14 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQV 72
L+ G GF + G K G +R + PG A+ L+ GD ++++ G NV+G T QV
Sbjct: 251 LINDGSGLGFGIVGGK-TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQV 309
Query: 73 VQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLP---PAHDPWEPKPDWAHTG 129
Q ++ R+LV + A LP P P D +
Sbjct: 310 AQVLRNCGNSVRMLVARDPAGD-------ISVTPPAPAALPVALPTVASKGPGSDSSLFE 362
Query: 130 SHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG 189
+++ E +KD + L R+ GY H+ ++ G Y++S+ PGS A +G
Sbjct: 363 TYNVELVRKDG----QSLGIRIV-------GYVGTSHTGEA-SGIYVKSIIPGSAAYHNG 410
Query: 190 -LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHV 248
++ D+++ V+G N++G + +VV ++ L +V +T L V
Sbjct: 411 HIQVNDKIVAVDGVNIQGFANHDVVEVLRNAGQVVHLTLVRRKTSSSTSPLEPPSDRGTV 470
Query: 249 EGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDG-SAWKQDPFQE-SGLHLSPTA 306
PL P T A + +++ G D++ ++ K D Q L P +
Sbjct: 471 VEPLKPPALFLT--------GAVETETNVDGEDEEIKERIDTLKNDNIQALEKLEKVPDS 522
Query: 307 AEAKEKAR 314
E + K+R
Sbjct: 523 PENELKSR 530
Score = 57.4 bits (137), Expect = 2e-08
Identities = 53/211 (25%), Positives = 91/211 (43%), Gaps = 16/211 (7%)
Query: 19 QGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIK 77
+G G + G++ G FI + G A+ L GD+++ VNG ++ + V +K
Sbjct: 1542 RGLGLSIVGKRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILK 1601
Query: 78 AVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGK 137
+G +L + R T + +Q AH P TG + G
Sbjct: 1602 CAQGLVQLEIGRLRAGSWTSART---TSQNSQGSQQSAHSSCHPSFAPVITGLQNL-VGT 1657
Query: 138 KDVSGPLR-----ELRPRLCHL-RKGPQGYGFNLHSDKSRP----GQYIRSVDPGSPAAR 187
K VS P + ++ PR + R+ G ++ + P +I + AAR
Sbjct: 1658 KRVSDPSQKNSGTDMEPRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAAR 1717
Query: 188 SG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
+ L+ DR++ +NGQ ++GL HA+VV +K
Sbjct: 1718 TQKLKVGDRIVSINGQPLDGLSHADVVNLLK 1748
Score = 51.2 bits (121), Expect = 1e-06
Identities = 60/282 (21%), Positives = 102/282 (36%), Gaps = 61/282 (21%)
Query: 11 LCRLVRGEQGYGFHLHGEKGRRGQ--FIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 67
+ L + + G G L G K R F+ + P PA A +R GD L+E+N + G
Sbjct: 1239 IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQILYGR 1298
Query: 68 THHQVVQRIKAVEGQTRLLVV-----------------------------------DQET 92
+H IK + +L+ + +++
Sbjct: 1299 SHQNASAIIKTAPSKVKLVFIRNEDAVNQMAVTPFPVPSSSPSSIEDQSGTEPISSEEDG 1358
Query: 93 DEELRRRQLTCTE-------EMAQRGLP-------------PAHDPWEPKPDWAHTGSHS 132
E+ +QL +E +M Q+ P PA D+ G
Sbjct: 1359 SVEVGIKQLPESESFKLAVSQMKQQKYPTKVSFSSQEIPLAPASSYHSTDADFTGYGGFQ 1418
Query: 133 SEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRP--GQYIRSVDPGSPAARSG- 189
+ + P+ + + + KG G G ++ K P I V AAR G
Sbjct: 1419 APLSVDPATCPIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGR 1478
Query: 190 LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPE 231
L A D+++EVNG ++ H E + +++ + RL+V E
Sbjct: 1479 LWAGDQILEVNGVDLRNSSHEEAITALRQTPQKVRLVVYRDE 1520
Score = 42.7 bits (99), Expect = 5e-04
Identities = 51/193 (26%), Positives = 82/193 (42%), Gaps = 24/193 (12%)
Query: 35 FIRRVEPGSPAEAAAL-RAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETD 93
+I + G P + L + D L+EVNG+ + G++ + V +K V L+ + D
Sbjct: 582 YISSIVSGGPVDTLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLVCCRRLFD 641
Query: 94 EELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRP--RL 151
+E + TE P+ + H ++E +D G L P ++
Sbjct: 642 DEASVDEPRRTETSL------------PETEVDHNMDVNTE---EDDDGELALWSPEVKI 686
Query: 152 CHLRKGPQGYGFNLHS-----DKSRPGQYIRSVDPGSPAARS-GLRAQDRLIEVNGQNVE 205
L K +G GF++ D +R IRS+ A RS GL DRL+ VN ++
Sbjct: 687 VELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYCLD 746
Query: 206 GLRHAEVVASIKA 218
AE V +KA
Sbjct: 747 NTSLAEAVEILKA 759
Score = 42.0 bits (97), Expect = 8e-04
Identities = 32/113 (28%), Positives = 52/113 (46%), Gaps = 6/113 (5%)
Query: 6 PLRPRLCRLVRGEQGYGFHLHGEKGR--RGQFIRRV-EPGSPAEAAALRAGDRLVEVNGV 62
P + + + +G G G + G K I V E G+ A L AGD+++EVNGV
Sbjct: 1432 PGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGV 1491
Query: 63 NVEGETHHQVVQRIKAVEGQTRLLVVDQET---DEELRRRQLTCTEEMAQRGL 112
++ +H + + ++ + RL+V E DEE ++ A RGL
Sbjct: 1492 DLRNSSHEEAITALRQTPQKVRLVVYRDEAHYRDEENLEIFPVDLQKKAGRGL 1544
Score = 35.4 bits (80), Expect = 0.073
Identities = 18/47 (38%), Positives = 26/47 (55%)
Query: 42 GSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVV 88
G A L+ GDR+V +NG ++G +H VV +K G+ L VV
Sbjct: 1713 GVAARTQKLKVGDRIVSINGQPLDGLSHADVVNLLKNAYGRIILQVV 1759
>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform c [Homo sapiens]
Length = 1462
Score = 71.6 bits (174), Expect = 9e-13
Identities = 67/296 (22%), Positives = 116/296 (39%), Gaps = 20/296 (6%)
Query: 36 IRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDE 94
I R+ GSPA+ L+ GDR++ VNG ++ ++H +V IK L ++ DE
Sbjct: 1009 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII--PGDE 1066
Query: 95 ELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGP--LRELRPRLC 152
LT E++A + H P + + + + + P +E
Sbjct: 1067 SSNATLLTNAEKIAT--ITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTV 1124
Query: 153 HLRKGPQGYGFNLHSDKS-RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHA 210
L +G +G+GF+L + Y+ + PA R G +R D ++E+NG+ + ++H+
Sbjct: 1125 ELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHS 1184
Query: 211 EVVASIKAREDEARLLV---------VDPETDEHFKRLRVTPTEEHVEGP--LPSPVTNG 259
+ IK RL + DP +D H E GP P
Sbjct: 1185 RAIELIKNGGRRVRLFLKRGDGSVPEYDPSSDRHGPATGPQGVPEVRAGPDRRQHPSLES 1244
Query: 260 TSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKARA 315
+ P L+ S + K + + S + +G P + + K RA
Sbjct: 1245 SYPPDLHKSSPHGEKRAHARDPKGSREYSRQPNEHHTWNGTSRKPDSGACRPKDRA 1300
Score = 56.2 bits (134), Expect = 4e-08
Identities = 66/254 (25%), Positives = 97/254 (38%), Gaps = 77/254 (30%)
Query: 13 RLVRGEQGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHH 70
+L + +G+GF + G E Q V G A + GD +V VN V G TH
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 71 QVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPD------ 124
QVV+ +++ + D EL C RG P DP +P
Sbjct: 534 QVVKIFQSIP-------IGASVDLEL------C------RGYPLPFDPDDPNTSLVTSVA 574
Query: 125 --------------WAHTGSHSSEAGKKDVSGPLRELRPR-------------------- 150
+ SHSS+ GK V+G +++ RP
Sbjct: 575 ILDKEPIIVNGQETYDSPASHSSKTGK--VNG-MKDARPSSPADVASNSSHGYPNDTVSL 631
Query: 151 -----------LCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
H+ KGP G+GF + GQ ++ + SP R GL+ D ++EV
Sbjct: 632 ASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQI-VDSPRCR-GLKEGDLIVEV 689
Query: 200 NGQNVEGLRHAEVV 213
N +NV+ L H +VV
Sbjct: 690 NKKNVQALTHNQVV 703
Score = 52.0 bits (123), Expect = 8e-07
Identities = 71/288 (24%), Positives = 115/288 (39%), Gaps = 50/288 (17%)
Query: 14 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVV 73
+V+G G+GF + G GQ ++++ SP L+ GD +VEVN NV+ TH+QVV
Sbjct: 646 IVKGPMGFGFTIADSPGGGGQRVKQIVD-SP-RCRGLKEGDLIVEVNKKNVQALTHNQVV 703
Query: 74 QR-IKAVEGQTRLLVVDQ---------------ETDEELRRRQLTCTEEMAQRGLPPAHD 117
++ +G L+V + E + Q + + + P+H
Sbjct: 704 DMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHS 763
Query: 118 PW---EPKPDWAHTGSHSSEAGKKD-------------VSGPLRELRPRLCHLRKGPQGY 161
E P A + +G+K L + + + L + G+
Sbjct: 764 TQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRLPDYQEQDIFLWRKETGF 823
Query: 162 GFNLHSDKSRPGQ--YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK- 217
GF + + PG+ YI + P A G LR+ D LI V+G V G H VV ++
Sbjct: 824 GFRILGG-NEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVVQLMQQ 882
Query: 218 -AREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTNGTSPAQ 264
A++ L V R +V E +PSP ++ S Q
Sbjct: 883 AAKQGHVNLTV----------RRKVVFAVPKTENEVPSPASSHHSSNQ 920
>gi|31742501 sorting nexin family member 27 [Homo sapiens]
Length = 528
Score = 70.9 bits (172), Expect = 2e-12
Identities = 39/93 (41%), Positives = 53/93 (56%), Gaps = 13/93 (13%)
Query: 9 PRLCRLVRGEQGYGFHLHGEKGRRGQF-------------IRRVEPGSPAEAAALRAGDR 55
PR+ R+V+ E GYGF++ G+ GQ + V PG A+ A +R GDR
Sbjct: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
Query: 56 LVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVV 88
++EVN VNVEG TH QVV I+A E + L V+
Sbjct: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
Score = 61.2 bits (147), Expect = 1e-09
Identities = 36/93 (38%), Positives = 49/93 (52%), Gaps = 13/93 (13%)
Query: 149 PRLCHLRKGPQGYGFNLHSDKSRPGQ-------------YIRSVDPGSPAARSGLRAQDR 195
PR+ + K GYGFN+ S GQ ++ +V PG A R+G+R DR
Sbjct: 41 PRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADRAGVRKGDR 100
Query: 196 LIEVNGQNVEGLRHAEVVASIKAREDEARLLVV 228
++EVN NVEG H +VV I+A E E L V+
Sbjct: 101 ILEVNHVNVEGATHKQVVDLIRAGEKELILTVL 133
>gi|148746189 multiple PDZ domain protein [Homo sapiens]
Length = 2041
Score = 70.5 bits (171), Expect = 2e-12
Identities = 59/200 (29%), Positives = 90/200 (45%), Gaps = 27/200 (13%)
Query: 35 FIRRVEP-GSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETD 93
FI + P G A+ LR GDR+V + G + EG TH Q V +K G + VV
Sbjct: 1862 FIAMMHPTGVAAQTQKLRVGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVVAGGDV 1921
Query: 94 EELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCH 153
+ Q +E A L + TG SS + D+ P + +
Sbjct: 1922 SVVTGHQ----QEPASSSL-------------SFTGLTSSSIFQDDLGPP----QCKSIT 1960
Query: 154 LRKGPQGYGFNLHSDKSRPGQ----YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLR 208
L +GP G GF++ P Y+++V A+ G L+ D++I VNGQ++EG+
Sbjct: 1961 LERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQSLEGVT 2020
Query: 209 HAEVVASIKAREDEARLLVV 228
H E VA +K + L+V+
Sbjct: 2021 HEEAVAILKRTKGTVTLMVL 2040
Score = 67.0 bits (162), Expect = 2e-11
Identities = 69/293 (23%), Positives = 116/293 (39%), Gaps = 55/293 (18%)
Query: 17 GEQGYGFHLHGEKGRRGQFIRRVEPGSPA-EAAALRAGDRLVEVNGVNVEGETHHQVVQR 75
G +G G L + RG FI+ V SPA + L+ GDR+VEV+G+++ +H Q V+
Sbjct: 1168 GGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEA 1227
Query: 76 IKAVEGQTRLLVVD-----------------------QETDEELRRRQLTCTEEMAQRGL 112
I+ +V T+ Q+ + +Q
Sbjct: 1228 IRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSES 1287
Query: 113 PPAHDPW-----EPKPDWAHTGSHSSEAGKKDVSGPL----------RELRPR------- 150
P P P +A GS +++ +S + + +R R
Sbjct: 1288 EPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKISQDVDKEDEFGYSWKNIRERYGTLTGE 1347
Query: 151 --LCHLRKGPQGYGFNL--HSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVE 205
+ L KG G G +L + D+SR +I +DP A + G L+ D L+E+NGQ +
Sbjct: 1348 LHMIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILY 1407
Query: 206 GLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTN 258
G H + IK + +++ + + ++ V P + PLPS N
Sbjct: 1408 GRSHQNASSIIKCAPSKVKIIFI--RNKDAVNQMAVCP--GNAVEPLPSNSEN 1456
Score = 60.8 bits (146), Expect = 2e-09
Identities = 71/234 (30%), Positives = 98/234 (41%), Gaps = 34/234 (14%)
Query: 20 GYGFHLHGEKGRRGQFIRRVEPGSPA-EAAALRAGDRLVEVNGVNVEGETHHQVVQRIKA 78
G G L G FIR V P P + L +GD L+EVNG+ + GE H VV +K
Sbjct: 564 GLGISLEATVGHH--FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKE 621
Query: 79 VEGQTRLL----VVDQETDEELRRRQLTCTEEMAQR---------GLPPAHDPWEPKPDW 125
+ + ++ V T EL L C E+ ++ G DP D
Sbjct: 622 LPIEVTMVCCRRTVPPTTQSELDSLDL-CDIELTEKPHVDLGEFIGSSETEDPVLAMTD- 679
Query: 126 AHTGSHSSEAGKKDVSGPLRELRPRLCH--LRKGPQGYGFNL--HSDKSRPGQ---YIRS 178
S+E +V PL + H L KG +G GF++ + D P IRS
Sbjct: 680 ---AGQSTE----EVQAPLAMWEAGIQHIELEKGSKGLGFSILDYQDPIDPASTVIIIRS 732
Query: 179 VDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK-AREDEARLLVVDP 230
+ PG A + G L DRL+ VN N+E E V ++K A R+ V P
Sbjct: 733 LVPGGIAEKDGRLLPGDRLMFVNDVNLENSSLEEAVEALKGAPSGTVRIGVAKP 786
Score = 55.8 bits (133), Expect = 5e-08
Identities = 62/274 (22%), Positives = 113/274 (41%), Gaps = 43/274 (15%)
Query: 14 LVRGEQGYGFHLHGEKGRR-----GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGE 67
L + QG G + G G + G F++ + S E ++ GD+++ V+G N++G
Sbjct: 380 LTKNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGF 439
Query: 68 THHQVVQRIKAVEGQTRLLVV----DQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKP 123
T+ Q V+ ++ GQT LL + ++ E + R +T +++ + +E
Sbjct: 440 TNQQAVEVLRHT-GQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASIIKENYEKDE 498
Query: 124 DWAHTGSHSS-----EAGKKDVSGPLRELRPR----------------------LCHLRK 156
D+ + +++ E G +S + E+ + H+ K
Sbjct: 499 DFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVAHVSK 558
Query: 157 GPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVAS 215
+ G + + + +IRSV P P SG L + D L+EVNG + G H +VV
Sbjct: 559 FSENSGLGISLEATVGHHFIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNI 618
Query: 216 IKAREDEARLL----VVDPETDEHFKRLRVTPTE 245
+K E ++ V P T L + E
Sbjct: 619 LKELPIEVTMVCCRRTVPPTTQSELDSLDLCDIE 652
Score = 45.8 bits (107), Expect = 5e-05
Identities = 30/92 (32%), Positives = 49/92 (53%), Gaps = 8/92 (8%)
Query: 5 EPLRPRLCR---LVRGEQGYGFHLHGEKGR-RGQ---FIRRV-EPGSPAEAAALRAGDRL 56
+ L P C+ L RG G GF + G G G +++ V G+ +E L+ GD++
Sbjct: 1949 DDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQI 2008
Query: 57 VEVNGVNVEGETHHQVVQRIKAVEGQTRLLVV 88
+ VNG ++EG TH + V +K +G L+V+
Sbjct: 2009 IAVNGQSLEGVTHEEAVAILKRTKGTVTLMVL 2040
Score = 42.0 bits (97), Expect = 8e-04
Identities = 47/217 (21%), Positives = 82/217 (37%), Gaps = 41/217 (18%)
Query: 19 QGYGFHLHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIK 77
+G G + G++ G F+ + G A+A L GD+++ VNG +V T V +K
Sbjct: 1734 KGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK 1793
Query: 78 AVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGK 137
EG P + + S S + K
Sbjct: 1794 VSEGSLSSFTF--------------------------------PLSGSSTSESLESSSKK 1821
Query: 138 KDVSGPLRELRPRLCHLRKGP-QGYGFNLHSDKSRP----GQYIRSVDPGSPAARS-GLR 191
++ ++ L R ++KGP G ++ P +I + P AA++ LR
Sbjct: 1822 NALASEIQGL--RTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLR 1879
Query: 192 AQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVV 228
DR++ + G + EG+ H + V +K + VV
Sbjct: 1880 VGDRIVTICGTSTEGMTHTQAVNLLKNASGSIEMQVV 1916
Score = 40.4 bits (93), Expect = 0.002
Identities = 60/289 (20%), Positives = 109/289 (37%), Gaps = 26/289 (8%)
Query: 10 RLCRLVRGEQGYGFHLHGEKGRRGQFIRRV-EPGSPAEAAALRAGDRLVEVNGVNVEGET 68
R + +G G + K G +R + G+ + + GD ++ +N + T
Sbjct: 1007 RTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEESTISVT 1066
Query: 69 HHQ---VVQRIKAVEGQTRLLVVDQETDEEL---------RRRQLTCTEEMAQRGLP--P 114
+ Q +++R + ++ V E EE R L R +P P
Sbjct: 1067 NAQARAMLRRHSLIGPDIKITYVPAEHLEEFKISLGQQSGRVMALDIFSSYTGRDIPELP 1126
Query: 115 AHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQ 174
+ E + ++S+ + V RE L G +G G L + + G
Sbjct: 1127 EREEGEGEESELQNTAYSNWNQPRRVE-LWREPSKSLGISIVGGRGMGSRLSNGEVMRGI 1185
Query: 175 YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETD 233
+I+ V SPA ++G L+ DR++EV+G ++ H + V +I+ + +V
Sbjct: 1186 FIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPVVFMV-----Q 1240
Query: 234 EHFKRLRVTPTEEHVEGPLPSPVTNGTSP----AQLNGGSACSSRSDLP 278
R R +P + P + T+P Q+N A S P
Sbjct: 1241 SIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKAPSQSESEP 1289
Score = 36.6 bits (83), Expect = 0.033
Identities = 35/182 (19%), Positives = 66/182 (36%), Gaps = 47/182 (25%)
Query: 40 EPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRR 99
E G+ + L AGD+++EVNG+++ TH + + ++ + RL + E +
Sbjct: 1661 EEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDEAPYKEEEV 1720
Query: 100 QLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQ 159
T T E+ +K +
Sbjct: 1721 CDTLTIELQ----------------------------------------------KKPGK 1734
Query: 160 GYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
G G ++ ++ G ++ + G A G L D+++ VNG++V V A +K
Sbjct: 1735 GLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLKV 1794
Query: 219 RE 220
E
Sbjct: 1795 SE 1796
Score = 33.9 bits (76), Expect = 0.21
Identities = 47/227 (20%), Positives = 83/227 (36%), Gaps = 9/227 (3%)
Query: 14 LVRGEQGYGFHLHGEKGRRGQFIRRV-EPGSPAEAAALRAGDRLVEVNGVNVEGETHHQV 72
L + + G G + E G I+ + E G A L+ GD+++ V+ V G +
Sbjct: 1486 LPKDQGGLGIAISEEDTLSGVIIKSLTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKF 1545
Query: 73 VQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE--PKPDWAHTGS 130
+ +K + +L + + D + + P P+P+ S
Sbjct: 1546 ISLLKTAKMTVKLTIHAENPDSQAVPSAAGAASGEKKNSSQSLMVPQSGSPEPESIRNTS 1605
Query: 131 HSSEAG---KKDVSGPLRELRPRLCHLRKGPQGYGFNL--HSDKSRPGQYIRSVDPGSPA 185
SS + P+ + KG G G ++ SD I V A
Sbjct: 1606 RSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGAIIIHEVYEEGAA 1665
Query: 186 ARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPE 231
+ G L A D+++EVNG ++ H E + ++ RL + E
Sbjct: 1666 CKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTLYRDE 1712
Score = 30.8 bits (68), Expect = 1.8
Identities = 21/97 (21%), Positives = 44/97 (45%), Gaps = 4/97 (4%)
Query: 145 RELRPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQN 203
+E R ++ KG G + ++K G +RS+ G +R G + D ++ +N ++
Sbjct: 1002 KESFERTINIAKGNSSLGMTVSANKDGLGMIVRSIIHGGAISRDGRIAIGDCILSINEES 1061
Query: 204 VEGLRHAEVVASIKARE---DEARLLVVDPETDEHFK 237
+ +A+ A ++ + ++ V E E FK
Sbjct: 1062 TISVTNAQARAMLRRHSLIGPDIKITYVPAEHLEEFK 1098
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 69.7 bits (169), Expect = 3e-12
Identities = 79/271 (29%), Positives = 114/271 (42%), Gaps = 47/271 (17%)
Query: 14 LVRGEQGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQ 71
L R E G+GF + G E G+ + GS L GD LV V+G+ V G+TH
Sbjct: 781 LRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRY 840
Query: 72 VVQRIK--AVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWE---PKPDWA 126
V+ + A GQ L V RR+ L E + G P P+ D+A
Sbjct: 841 VIDLMHHAARNGQVNLTV---------RRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYA 891
Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHL------RKGPQGYGFNLHSDKSRPGQ------ 174
T ++S+ A + P RK +G+GF + S +RP
Sbjct: 892 -TYTNSNHAAPSSNASPPEGFASHSLQTSDVVIHRKENEGFGFVIISSLNRPESGSTITV 950
Query: 175 --YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPE 231
I + GSPA R L+ DR++ VNGQ++ + HA++V IK +A L V
Sbjct: 951 PHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIK----DAGLSVT--- 1003
Query: 232 TDEHFKRLRVTPTEEHVEGPLPSPVTNGTSP 262
LR+ P EE + P +P + SP
Sbjct: 1004 -------LRIIPQEE-LNSPTSAPSSEKQSP 1026
Score = 46.6 bits (109), Expect = 3e-05
Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 7/88 (7%)
Query: 154 LRKGPQGYGFNLHSDKS-RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAE 211
+ KG +G+GF++ + + Y+ + PA R+G +R D++IE+NG++ + HA
Sbjct: 1150 MEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHAR 1209
Query: 212 VVASIKAREDEARLLVVD-----PETDE 234
+ IK+ RLL+ PE DE
Sbjct: 1210 AIELIKSGGRRVRLLLKRGTGQVPEYDE 1237
Score = 44.7 bits (104), Expect = 1e-04
Identities = 62/243 (25%), Positives = 100/243 (41%), Gaps = 51/243 (20%)
Query: 14 LVRGEQGYGFHL-HGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQV 72
+V+G QG+GF + G+R + I ++ G P L GD +VE+N NV+ +H +V
Sbjct: 608 IVKGAQGFGFTIADSPTGQRVKQILDIQ-GCPG----LCEGDLIVEINQQNVQNLSHTEV 662
Query: 73 VQRIK--AVEGQTRLL---------------VVDQETDEELRRRQLTCTEEMAQRGLPP- 114
V +K + +T L+ ++D+ ++ + L+ PP
Sbjct: 663 VDILKDCPIGSETSLIIHRGGFFSPWKTPKPIMDRWENQGSPQTSLSAPAIPQNLPFPPA 722
Query: 115 -----------AHDPWEPKPDWAHTGSHSSEAGKK----------DVSGPLRELRPRLCH 153
A DP +P P + S + ++ D SGP + + H
Sbjct: 723 LHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGP--DYKELDVH 780
Query: 154 LRKGPQGYGFNLHSDKSRPGQ--YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHA 210
LR+ G+GF + PGQ I +V A R G L D L+ V+G V G H
Sbjct: 781 LRRMESGFGFRILGG-DEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHR 839
Query: 211 EVV 213
V+
Sbjct: 840 YVI 842
Score = 44.3 bits (103), Expect = 2e-04
Identities = 64/252 (25%), Positives = 95/252 (37%), Gaps = 61/252 (24%)
Query: 14 LVRGEQGYGFHL-HGEKGRRGQFIRRVEPGSPA-EAAALRAGDRLVEVNGVNVEGETHHQ 71
L + G+GF + G++ ++ V P PA + + GD +V +N V V G TH
Sbjct: 429 LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHAD 488
Query: 72 VVQRIKAVE-GQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGS 130
VV+ ++V GQ+ LV+ R L E + P E P G
Sbjct: 489 VVKLFQSVPIGQSVNLVL-------CRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGR 541
Query: 131 HSSEAGKKDVS-----------------------GPLRELRPRLCH-------------- 153
H+ E + +S G L P H
Sbjct: 542 HNYETYLEYISRTSQSVPDITDRPPHSLHSMPTDGQLDGTYPPPVHDDNVSMASSGATQA 601
Query: 154 ------LRKGPQGYGFNLHSDKSRPGQYIRSV--DPGSPAARSGLRAQDRLIEVNGQNVE 205
+ KG QG+GF + S GQ ++ + G P GL D ++E+N QNV+
Sbjct: 602 ELMTLTIVKGAQGFGFTIAD--SPTGQRVKQILDIQGCP----GLCEGDLIVEINQQNVQ 655
Query: 206 GLRHAEVVASIK 217
L H EVV +K
Sbjct: 656 NLSHTEVVDILK 667
Score = 43.5 bits (101), Expect = 3e-04
Identities = 21/74 (28%), Positives = 40/74 (54%), Gaps = 2/74 (2%)
Query: 16 RGEQGYGFHLHGEKGRRGQF--IRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVV 73
+G +G+GF + G + + +R E G +R GD+++E+NG + TH + +
Sbjct: 1152 KGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAI 1211
Query: 74 QRIKAVEGQTRLLV 87
+ IK+ + RLL+
Sbjct: 1212 ELIKSGGRRVRLLL 1225
>gi|140561024 CASK-interacting protein CIP98 isoform 1 [Homo
sapiens]
Length = 907
Score = 68.6 bits (166), Expect = 8e-12
Identities = 64/235 (27%), Positives = 100/235 (42%), Gaps = 37/235 (15%)
Query: 2 AAPEPLRPRLCRLVRGEQGYGFHLHGEKGRR-GQFIRRVEPGSPAEAAALRAGDRLVEVN 60
A P +R R + +G GF + G G ++ VEPGS AE LR GD+++ VN
Sbjct: 133 AGPGEVRLVSLRRAKAHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVN 192
Query: 61 GVNVEGETHHQVVQRIKAVEGQTRLLV----VDQETDEELRRRQLTCTEEMAQRGLPPAH 116
++ TH + +KA++G +L++ + + T + + PP+
Sbjct: 193 DKSLARVTH---AEAVKALKGSKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSISPPSG 249
Query: 117 DPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRP---- 172
P +P H G+ + G R HL +G NL R
Sbjct: 250 LP-QP-----HGGALRQQEGD----------RRSTLHLLQGGDEKKVNLVLGDGRSLGLT 293
Query: 173 ---------GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
G YI VDPGS A SGL+ D+++EVNG++ + H E V +K+
Sbjct: 294 IRGGAEYGLGIYITGVDPGSEAEGSGLKVGDQILEVNGRSFLNILHDEAVRLLKS 348
Score = 48.9 bits (115), Expect = 6e-06
Identities = 37/122 (30%), Positives = 58/122 (47%), Gaps = 13/122 (10%)
Query: 97 RRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLCHLRK 156
R QL + A+ PA P+ +P W G D +GP E+R K
Sbjct: 100 RSDQLLFDQYTAEGLYLPATTPYR-QPAW----------GGPDSAGP-GEVRLVSLRRAK 147
Query: 157 GPQGYGFNLHSDKSRP-GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVAS 215
+G GF++ G Y+ V+PGS A + GLR D+++ VN +++ + HAE V +
Sbjct: 148 AHEGLGFSIRGGSEHGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVTHAEAVKA 207
Query: 216 IK 217
+K
Sbjct: 208 LK 209
>gi|41281808 harmonin isoform b3 [Homo sapiens]
Length = 899
Score = 67.0 bits (162), Expect = 2e-11
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 37/226 (16%)
Query: 6 PLRPRLCRLVRGE----QGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEV 59
P R R + VR + +G G + G E G G FI + G A++ L+ GD +V +
Sbjct: 79 PRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGC-GLFISHLIKGGQADSVGLQVGDEIVRI 137
Query: 60 NGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPW 119
NG ++ TH +V+ I R + T + ++ GL P
Sbjct: 138 NGYSISSCTHEEVINLI---------------------RTKKTVSIKVRHIGLIPVKSSP 176
Query: 120 EPKPDWAHTGSHSSEAGKKDVSGPL-----RELRPRLCHLRK-GPQGYGFNLHSDK-SRP 172
+ W + SE+G V G L RE + + + G +G G ++ S +P
Sbjct: 177 DEPLTWQYVDQFVSESG--GVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKP 234
Query: 173 GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
G +I V PGS +A GL D+++EVNG + L H E V +K+
Sbjct: 235 GIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
Score = 48.9 bits (115), Expect = 6e-06
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 10/106 (9%)
Query: 17 GEQGYGFHLH-GEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQR 75
G +G G + G + G FI V+PGS + L GD++VEVNGV+ H + V
Sbjct: 218 GSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNV 277
Query: 76 IKAVEGQT---------RLLVVDQETDEELRRRQLTCTEEMAQRGL 112
+K+ T L + D+E E R+R+L E + Q+ L
Sbjct: 278 LKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRL 323
Score = 33.9 bits (76), Expect = 0.21
Identities = 21/81 (25%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 141 SGPLRELRPRLCHLRKGPQGYGFNLHSD-KSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
S L+E+R H P+G G ++ + G +I + G A GL+ D ++ +
Sbjct: 82 SRKLKEVRLDRLH----PEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRI 137
Query: 200 NGQNVEGLRHAEVVASIKARE 220
NG ++ H EV+ I+ ++
Sbjct: 138 NGYSISSCTHEEVINLIRTKK 158
>gi|71480164 harmonin isoform a [Homo sapiens]
Length = 552
Score = 67.0 bits (162), Expect = 2e-11
Identities = 63/226 (27%), Positives = 99/226 (43%), Gaps = 37/226 (16%)
Query: 6 PLRPRLCRLVRGE----QGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEV 59
P R R + VR + +G G + G E G G FI + G A++ L+ GD +V +
Sbjct: 79 PRRSRKLKEVRLDRLHPEGLGLSVRGGLEFGC-GLFISHLIKGGQADSVGLQVGDEIVRI 137
Query: 60 NGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPW 119
NG ++ TH +V+ I R + T + ++ GL P
Sbjct: 138 NGYSISSCTHEEVINLI---------------------RTKKTVSIKVRHIGLIPVKSSP 176
Query: 120 EPKPDWAHTGSHSSEAGKKDVSGPL-----RELRPRLCHLRK-GPQGYGFNLHSDK-SRP 172
+ W + SE+G V G L RE + + + G +G G ++ S +P
Sbjct: 177 DEPLTWQYVDQFVSESG--GVRGSLGSPGNRENKEKKVFISLVGSRGLGCSISSGPIQKP 234
Query: 173 GQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEVVASIKA 218
G +I V PGS +A GL D+++EVNG + L H E V +K+
Sbjct: 235 GIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNVLKS 280
Score = 48.9 bits (115), Expect = 6e-06
Identities = 34/106 (32%), Positives = 51/106 (48%), Gaps = 10/106 (9%)
Query: 17 GEQGYGFHLH-GEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVVQR 75
G +G G + G + G FI V+PGS + L GD++VEVNGV+ H + V
Sbjct: 218 GSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLEIGDQIVEVNGVDFSNLDHKEAVNV 277
Query: 76 IKAVEGQT---------RLLVVDQETDEELRRRQLTCTEEMAQRGL 112
+K+ T L + D+E E R+R+L E + Q+ L
Sbjct: 278 LKSSRSLTISIVAAAGRELFMTDRERLAEARQRELQRQELLMQKRL 323
Score = 33.9 bits (76), Expect = 0.21
Identities = 21/81 (25%), Positives = 39/81 (48%), Gaps = 5/81 (6%)
Query: 141 SGPLRELRPRLCHLRKGPQGYGFNLHSD-KSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
S L+E+R H P+G G ++ + G +I + G A GL+ D ++ +
Sbjct: 82 SRKLKEVRLDRLH----PEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQVGDEIVRI 137
Query: 200 NGQNVEGLRHAEVVASIKARE 220
NG ++ H EV+ I+ ++
Sbjct: 138 NGYSISSCTHEEVINLIRTKK 158
>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform b [Homo sapiens]
Length = 1256
Score = 67.0 bits (162), Expect = 2e-11
Identities = 49/197 (24%), Positives = 88/197 (44%), Gaps = 9/197 (4%)
Query: 36 IRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDE 94
I R+ GSPA+ L+ GDR++ VNG ++ ++H +V IK L ++ DE
Sbjct: 1038 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII--PGDE 1095
Query: 95 ELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGP--LRELRPRLC 152
LT E++A + H P + + + + + P +E
Sbjct: 1096 SSNATLLTNAEKIAT--ITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTV 1153
Query: 153 HLRKGPQGYGFNLHSDKS-RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHA 210
L +G +G+GF+L + Y+ + PA R G +R D ++E+NG+ + ++H+
Sbjct: 1154 ELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHS 1213
Query: 211 EVVASIKAREDEARLLV 227
+ IK RL +
Sbjct: 1214 RAIELIKNGGRRVRLFL 1230
Score = 56.2 bits (134), Expect = 4e-08
Identities = 66/254 (25%), Positives = 97/254 (38%), Gaps = 77/254 (30%)
Query: 13 RLVRGEQGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHH 70
+L + +G+GF + G E Q V G A + GD +V VN V G TH
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 71 QVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPD------ 124
QVV+ +++ + D EL C RG P DP +P
Sbjct: 534 QVVKIFQSIP-------IGASVDLEL------C------RGYPLPFDPDDPNTSLVTSVA 574
Query: 125 --------------WAHTGSHSSEAGKKDVSGPLRELRPR-------------------- 150
+ SHSS+ GK V+G +++ RP
Sbjct: 575 ILDKEPIIVNGQETYDSPASHSSKTGK--VNG-MKDARPSSPADVASNSSHGYPNDTVSL 631
Query: 151 -----------LCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
H+ KGP G+GF + GQ ++ + SP R GL+ D ++EV
Sbjct: 632 ASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQI-VDSPRCR-GLKEGDLIVEV 689
Query: 200 NGQNVEGLRHAEVV 213
N +NV+ L H +VV
Sbjct: 690 NKKNVQALTHNQVV 703
Score = 54.7 bits (130), Expect = 1e-07
Identities = 67/258 (25%), Positives = 108/258 (41%), Gaps = 53/258 (20%)
Query: 14 LVRGEQGYGFH-LHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQ 71
L R E G+GF L G + +I + P A+ LR+GD L+ V+G V G++H
Sbjct: 844 LWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQL 903
Query: 72 VVQRIK--AVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLP-PA---HDPWEPK--- 122
VVQ ++ A +G L V RR++ + +P PA H +P
Sbjct: 904 VVQLMQQAAKQGHVNLTV----------RRKVVFAVPKTENEVPSPASSHHSSNQPASLT 953
Query: 123 -----PDWAHTGSHSSEAGKKDVSG-----------PLRELRPRLCHLRKGP-QGYGFNL 165
P + ++ +G SG ++P +R+G +G+GF +
Sbjct: 954 EEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVI 1013
Query: 166 HSDKSRPG--------------QYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHA 210
S SRP I + GSPA R G L+ DR++ VNG ++ H+
Sbjct: 1014 VSSVSRPEAGTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHS 1073
Query: 211 EVVASIKAREDEARLLVV 228
++V IK + L ++
Sbjct: 1074 DIVNLIKEAGNTVTLRII 1091
Score = 45.8 bits (107), Expect = 5e-05
Identities = 74/316 (23%), Positives = 119/316 (37%), Gaps = 78/316 (24%)
Query: 14 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVV 73
+V+G G+GF + G GQ ++++ SP L+ GD +VEVN NV+ TH+QVV
Sbjct: 646 IVKGPMGFGFTIADSPGGGGQRVKQIVD-SP-RCRGLKEGDLIVEVNKKNVQALTHNQVV 703
Query: 74 QR-IKAVEGQTRLLVVDQ---------------ETDEELRRRQLTCTEEMAQRGLPPAH- 116
++ +G L+V + E + Q + + + P+H
Sbjct: 704 DMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHS 763
Query: 117 -------------------DPWEPKPD----WAHTGS--HSSEAGKKDVSG--------- 142
+ KPD WA + S + SG
Sbjct: 764 TQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGERERE 823
Query: 143 ---------PLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQ--YIRSVDPGSPAARSG-L 190
P+ + + + L + G+GF + + PG+ YI + P A G L
Sbjct: 824 INSTNFGECPIPDYQEQDIFLWRKETGFGFRILGG-NEPGEPIYIGHIVPLGAADTDGRL 882
Query: 191 RAQDRLIEVNGQNVEGLRHAEVVASIK--AREDEARLLVVDPETDEHFKRLRVTPTEEHV 248
R+ D LI V+G V G H VV ++ A++ L V R +V
Sbjct: 883 RSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV----------RRKVVFAVPKT 932
Query: 249 EGPLPSPVTNGTSPAQ 264
E +PSP ++ S Q
Sbjct: 933 ENEVPSPASSHHSSNQ 948
>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
containing 1 isoform a [Homo sapiens]
Length = 1287
Score = 67.0 bits (162), Expect = 2e-11
Identities = 49/197 (24%), Positives = 88/197 (44%), Gaps = 9/197 (4%)
Query: 36 IRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDE 94
I R+ GSPA+ L+ GDR++ VNG ++ ++H +V IK L ++ DE
Sbjct: 1037 IGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEAGNTVTLRII--PGDE 1094
Query: 95 ELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGP--LRELRPRLC 152
LT E++A + H P + + + + + P +E
Sbjct: 1095 SSNATLLTNAEKIAT--ITTTHTPSQQGTQETRNTTKPKQESQFEFKAPQATQEQDFYTV 1152
Query: 153 HLRKGPQGYGFNLHSDKS-RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHA 210
L +G +G+GF+L + Y+ + PA R G +R D ++E+NG+ + ++H+
Sbjct: 1153 ELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHS 1212
Query: 211 EVVASIKAREDEARLLV 227
+ IK RL +
Sbjct: 1213 RAIELIKNGGRRVRLFL 1229
Score = 56.2 bits (134), Expect = 4e-08
Identities = 66/254 (25%), Positives = 97/254 (38%), Gaps = 77/254 (30%)
Query: 13 RLVRGEQGYGFHLHG--EKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHH 70
+L + +G+GF + G E Q V G A + GD +V VN V G TH
Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533
Query: 71 QVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPD------ 124
QVV+ +++ + D EL C RG P DP +P
Sbjct: 534 QVVKIFQSIP-------IGASVDLEL------C------RGYPLPFDPDDPNTSLVTSVA 574
Query: 125 --------------WAHTGSHSSEAGKKDVSGPLRELRPR-------------------- 150
+ SHSS+ GK V+G +++ RP
Sbjct: 575 ILDKEPIIVNGQETYDSPASHSSKTGK--VNG-MKDARPSSPADVASNSSHGYPNDTVSL 631
Query: 151 -----------LCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEV 199
H+ KGP G+GF + GQ ++ + SP R GL+ D ++EV
Sbjct: 632 ASSIATQPELITVHIVKGPMGFGFTIADSPGGGGQRVKQI-VDSPRCR-GLKEGDLIVEV 689
Query: 200 NGQNVEGLRHAEVV 213
N +NV+ L H +VV
Sbjct: 690 NKKNVQALTHNQVV 703
Score = 55.1 bits (131), Expect = 9e-08
Identities = 67/257 (26%), Positives = 108/257 (42%), Gaps = 52/257 (20%)
Query: 14 LVRGEQGYGFH-LHGEKGRRGQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQ 71
L R E G+GF L G + +I + P A+ LR+GD L+ V+G V G++H
Sbjct: 844 LWRKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQL 903
Query: 72 VVQRIK--AVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLP-PA---HDPWEPK--- 122
VVQ ++ A +G L V RR++ + +P PA H +P
Sbjct: 904 VVQLMQQAAKQGHVNLTV----------RRKVVFAVPKTENEVPSPASSHHSSNQPASLT 953
Query: 123 -----PDWAHTGSHSSEAGKKDVSG-----------PLRELRPRLCHLRKGP-QGYGFNL 165
P + ++ +G SG ++P +R+G +G+GF +
Sbjct: 954 EEKRTPQGSQNSLNTVSSGSGSTSGIGSGGGGGSGVVSTVVQPYDVEIRRGENEGFGFVI 1013
Query: 166 HSDKSRPG-------------QYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAE 211
S SRP I + GSPA R G L+ DR++ VNG ++ H++
Sbjct: 1014 VSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSD 1073
Query: 212 VVASIKAREDEARLLVV 228
+V IK + L ++
Sbjct: 1074 IVNLIKEAGNTVTLRII 1090
Score = 45.8 bits (107), Expect = 5e-05
Identities = 74/316 (23%), Positives = 119/316 (37%), Gaps = 78/316 (24%)
Query: 14 LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETHHQVV 73
+V+G G+GF + G GQ ++++ SP L+ GD +VEVN NV+ TH+QVV
Sbjct: 646 IVKGPMGFGFTIADSPGGGGQRVKQIVD-SP-RCRGLKEGDLIVEVNKKNVQALTHNQVV 703
Query: 74 QR-IKAVEGQTRLLVVDQ---------------ETDEELRRRQLTCTEEMAQRGLPPAH- 116
++ +G L+V + E + Q + + + P+H
Sbjct: 704 DMLVECPKGSEVTLLVQRGGLPVPKKSPKSQPLERKDSQNSSQHSVSSHRSLHTASPSHS 763
Query: 117 -------------------DPWEPKPD----WAHTGS--HSSEAGKKDVSG--------- 142
+ KPD WA + S + SG
Sbjct: 764 TQVLPEFPPAEAQAPDQTDSSGQKKPDPFKIWAQSRSMYENRPMSPSPASGLSKGERERE 823
Query: 143 ---------PLRELRPRLCHLRKGPQGYGFNLHSDKSRPGQ--YIRSVDPGSPAARSG-L 190
P+ + + + L + G+GF + + PG+ YI + P A G L
Sbjct: 824 INSTNFGECPIPDYQEQDIFLWRKETGFGFRILGG-NEPGEPIYIGHIVPLGAADTDGRL 882
Query: 191 RAQDRLIEVNGQNVEGLRHAEVVASIK--AREDEARLLVVDPETDEHFKRLRVTPTEEHV 248
R+ D LI V+G V G H VV ++ A++ L V R +V
Sbjct: 883 RSGDELICVDGTPVIGKSHQLVVQLMQQAAKQGHVNLTV----------RRKVVFAVPKT 932
Query: 249 EGPLPSPVTNGTSPAQ 264
E +PSP ++ S Q
Sbjct: 933 ENEVPSPASSHHSSNQ 948
>gi|8922944 lin-7 homolog C [Homo sapiens]
Length = 197
Score = 63.9 bits (154), Expect = 2e-10
Identities = 33/81 (40%), Positives = 53/81 (65%), Gaps = 2/81 (2%)
Query: 9 PRLCRLVRGEQGYGFHLHGEKGRRGQ-FIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEG 66
PR+ L + E+G GF++ G K + +I R+ PG A+ L+ GD+L+ VNGV+VEG
Sbjct: 91 PRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150
Query: 67 ETHHQVVQRIKAVEGQTRLLV 87
E H + V+ +KA +G+ +L+V
Sbjct: 151 EHHEKAVELLKAAQGKVKLVV 171
Score = 55.1 bits (131), Expect = 9e-08
Identities = 35/99 (35%), Positives = 54/99 (54%), Gaps = 7/99 (7%)
Query: 149 PRLCHLRKGPQGYGFNLHSDKSRPGQ-YIRSVDPGSPAAR-SGLRAQDRLIEVNGQNVEG 206
PR+ L K +G GFN+ K + YI + PG A R GL+ D+L+ VNG +VEG
Sbjct: 91 PRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150
Query: 207 LRHAEVVASIKAREDEARLLV-----VDPETDEHFKRLR 240
H + V +KA + + +L+V V E + F+++R
Sbjct: 151 EHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMR 189
>gi|11545920 lin-7 homolog B [Homo sapiens]
Length = 207
Score = 63.5 bits (153), Expect = 2e-10
Identities = 33/81 (40%), Positives = 52/81 (64%), Gaps = 2/81 (2%)
Query: 9 PRLCRLVRGEQGYGFHLHGEKGRRGQ-FIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEG 66
PR+ L + ++G GF++ G K + +I RV PG A+ L+ GD+L+ VNGV+VEG
Sbjct: 91 PRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
Query: 67 ETHHQVVQRIKAVEGQTRLLV 87
E H + V+ +KA +G +L+V
Sbjct: 151 EQHEKAVELLKAAQGSVKLVV 171
Score = 55.5 bits (132), Expect = 7e-08
Identities = 36/99 (36%), Positives = 54/99 (54%), Gaps = 7/99 (7%)
Query: 149 PRLCHLRKGPQGYGFNLHSDKSRPGQ-YIRSVDPGSPAAR-SGLRAQDRLIEVNGQNVEG 206
PR+ L K +G GFN+ K + YI V PG A R GL+ D+L+ VNG +VEG
Sbjct: 91 PRVVELPKTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEG 150
Query: 207 LRHAEVVASIKAREDEARLLV-----VDPETDEHFKRLR 240
+H + V +KA + +L+V V E + F+++R
Sbjct: 151 EQHEKAVELLKAAQGSVKLVVRYTPRVLEEMEARFEKMR 189
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 63.2 bits (152), Expect = 3e-10
Identities = 64/264 (24%), Positives = 98/264 (37%), Gaps = 44/264 (16%)
Query: 4 PEPLRPRLCRLVRGEQGYGFHLHGEKGRRG-------QFIRRVEPGSPAEAAALRAGDRL 56
P P L++G +G GF + G G + + +E G+ + L+ GDRL
Sbjct: 219 PPPETIMEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRL 278
Query: 57 VEVNGVNVEGETHHQVVQRIKAVEGQTRLLVV------------------------DQET 92
+ VN N++ H + V +K L V D
Sbjct: 279 LAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKPGSLHLNDMYAPPDYASTFTALADNHI 338
Query: 93 DEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRELRPRLC 152
L E PP P P H ++D + RE PR
Sbjct: 339 SHNSSLGYLGAVESKVSYPAPPQVPPTRYSPIPRHM------LAEEDFT---RE--PRKI 387
Query: 153 HLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAE 211
L KG G GFN+ + G ++ + G PA SG LR DR++ VNG N+ H +
Sbjct: 388 ILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQ 447
Query: 212 VVASIKAREDEARLLVVDPETDEH 235
A++K R ++ +V +E+
Sbjct: 448 AAAALK-RAGQSVTIVAQYRPEEY 470
Score = 57.8 bits (138), Expect = 1e-08
Identities = 64/231 (27%), Positives = 88/231 (38%), Gaps = 66/231 (28%)
Query: 14 LVRGEQGYGFHLHGEKGRR------GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEG 66
L RG G GF + G G FI ++ PG A L D ++ VN V+V
Sbjct: 134 LERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSE 193
Query: 67 ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
H + V+ +K RL+V RRRQ PP E
Sbjct: 194 VVHSRAVEALKEAGPVVRLVV---------RRRQ------------PPPETIME------ 226
Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHS---DKSRPGQ---YIRSVD 180
+L KGP+G GF++ ++ PG YI +
Sbjct: 227 -------------------------VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKII 261
Query: 181 PGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDP 230
G A + G L+ DRL+ VN N++ +RH E VAS+K D L V P
Sbjct: 262 EGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSDMVYLKVAKP 312
Score = 55.1 bits (131), Expect = 9e-08
Identities = 32/90 (35%), Positives = 47/90 (52%), Gaps = 2/90 (2%)
Query: 9 PRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGE 67
PR L +G G GF++ G + G F+ + G PA+ + LR GDR++ VNGVN+
Sbjct: 384 PRKIILHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNA 443
Query: 68 THHQVVQRIKAVEGQTRLLVVDQETDEELR 97
TH Q +K GQ+ +V +E R
Sbjct: 444 THEQAAAALKRA-GQSVTIVAQYRPEEYSR 472
>gi|18375650 protein tyrosine phosphatase, non-receptor type 13
isoform 4 [Homo sapiens]
Length = 2490
Score = 63.2 bits (152), Expect = 3e-10
Identities = 72/296 (24%), Positives = 124/296 (41%), Gaps = 55/296 (18%)
Query: 33 GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQE 91
G +++ V P AE+ + GDR++ VNGV++EG TH Q V+ ++ GQ L++++
Sbjct: 1399 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT-GQVVHLLLEKG 1457
Query: 92 TDEELRRR-----QLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRE 146
+ Q T +++ AQ P D++ ++ K
Sbjct: 1458 QSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVK--------- 1508
Query: 147 LRPRLCHLRKGPQGYGFNL-HSDKSRPGQY------IRSVDPGSPAARSG-LRAQDRLIE 198
L K G GF+ D P Q ++ + PG PAA SG + D +++
Sbjct: 1509 -------LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1561
Query: 199 VNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTN 258
VNG +++GL EV+++++ E LL+ P V P ++ L +P+
Sbjct: 1562 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG-------VLP---EIDTALLTPL-- 1609
Query: 259 GTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKAR 314
SPAQ+ LP S KD+ S +Q + + + K +R
Sbjct: 1610 -QSPAQV-----------LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1653
Score = 48.5 bits (114), Expect = 8e-06
Identities = 34/94 (36%), Positives = 51/94 (54%), Gaps = 6/94 (6%)
Query: 20 GYGFHL-HGEKGRR---GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQ 74
G GF + GEK R G FI V PG PA+ L+ GDRL+ VN V++EG +HH ++
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 75 RIK-AVEGQTRLLVVDQETDEELRRRQLTCTEEM 107
++ A E T ++ +E ++ + T EM
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEM 1196
Score = 45.1 bits (105), Expect = 9e-05
Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 10/110 (9%)
Query: 140 VSGPLRELRPRLCHLRKGPQ-GYGFNLHSDKSRP----GQYIRSVDPGSPAARSG-LRAQ 193
VS P RE+ L +L+K + G GF + + G +I SV PG PA G L+
Sbjct: 1084 VSSPEREIT--LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141
Query: 194 DRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
DRLI VN ++EG+ H + ++ ++ L++ P+ E ++ TP
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK--EKISKVPSTP 1189
Score = 38.1 bits (87), Expect = 0.011
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 11 LCRLVRGEQG-YGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETH 69
L L++ E+G GF + R G ++ V L+ GDRL++VN +V TH
Sbjct: 1793 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTH 1852
Query: 70 HQVVQRIKAVEGQTRLLV 87
V ++A RL++
Sbjct: 1853 TDAVNLLRAASKTVRLVI 1870
Score = 37.0 bits (84), Expect = 0.025
Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 26/140 (18%)
Query: 112 LPPAHDP---WEPKPDWAHTGS-------HSSEAGKKDVSGPLR--------------EL 147
LPP P ++P+ + A + S H SE +++ PL+ EL
Sbjct: 1733 LPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVEL 1792
Query: 148 RPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
L KG GF + R G Y+ V + L+ DRLI+VN +V +
Sbjct: 1793 LITLIKSEKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM 1850
Query: 208 RHAEVVASIKAREDEARLLV 227
H + V ++A RL++
Sbjct: 1851 THTDAVNLLRAASKTVRLVI 1870
>gi|18375648 protein tyrosine phosphatase, non-receptor type 13
isoform 3 [Homo sapiens]
Length = 2294
Score = 63.2 bits (152), Expect = 3e-10
Identities = 72/296 (24%), Positives = 124/296 (41%), Gaps = 55/296 (18%)
Query: 33 GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQE 91
G +++ V P AE+ + GDR++ VNGV++EG TH Q V+ ++ GQ L++++
Sbjct: 1203 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT-GQVVHLLLEKG 1261
Query: 92 TDEELRRR-----QLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRE 146
+ Q T +++ AQ P D++ ++ K
Sbjct: 1262 QSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVK--------- 1312
Query: 147 LRPRLCHLRKGPQGYGFNL-HSDKSRPGQY------IRSVDPGSPAARSG-LRAQDRLIE 198
L K G GF+ D P Q ++ + PG PAA SG + D +++
Sbjct: 1313 -------LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1365
Query: 199 VNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTN 258
VNG +++GL EV+++++ E LL+ P V P ++ L +P+
Sbjct: 1366 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG-------VLP---EIDTALLTPL-- 1413
Query: 259 GTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKAR 314
SPAQ+ LP S KD+ S +Q + + + K +R
Sbjct: 1414 -QSPAQV-----------LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1457
Score = 48.5 bits (114), Expect = 8e-06
Identities = 34/94 (36%), Positives = 51/94 (54%), Gaps = 6/94 (6%)
Query: 20 GYGFHL-HGEKGRR---GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQ 74
G GF + GEK R G FI V PG PA+ L+ GDRL+ VN V++EG +HH ++
Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971
Query: 75 RIK-AVEGQTRLLVVDQETDEELRRRQLTCTEEM 107
++ A E T ++ +E ++ + T EM
Sbjct: 972 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEM 1005
Score = 45.1 bits (105), Expect = 9e-05
Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 10/110 (9%)
Query: 140 VSGPLRELRPRLCHLRKGPQ-GYGFNLHSDKSRP----GQYIRSVDPGSPAARSG-LRAQ 193
VS P RE+ L +L+K + G GF + + G +I SV PG PA G L+
Sbjct: 893 VSSPEREIT--LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 950
Query: 194 DRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
DRLI VN ++EG+ H + ++ ++ L++ P+ E ++ TP
Sbjct: 951 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK--EKISKVPSTP 998
Score = 38.1 bits (87), Expect = 0.011
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 11 LCRLVRGEQG-YGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETH 69
L L++ E+G GF + R G ++ V L+ GDRL++VN +V TH
Sbjct: 1597 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTH 1656
Query: 70 HQVVQRIKAVEGQTRLLV 87
V ++A RL++
Sbjct: 1657 TDAVNLLRAASKTVRLVI 1674
Score = 37.0 bits (84), Expect = 0.025
Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 26/140 (18%)
Query: 112 LPPAHDP---WEPKPDWAHTGS-------HSSEAGKKDVSGPLR--------------EL 147
LPP P ++P+ + A + S H SE +++ PL+ EL
Sbjct: 1537 LPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVEL 1596
Query: 148 RPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
L KG GF + R G Y+ V + L+ DRLI+VN +V +
Sbjct: 1597 LITLIKSEKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM 1654
Query: 208 RHAEVVASIKAREDEARLLV 227
H + V ++A RL++
Sbjct: 1655 THTDAVNLLRAASKTVRLVI 1674
>gi|18375646 protein tyrosine phosphatase, non-receptor type 13
isoform 1 [Homo sapiens]
Length = 2485
Score = 63.2 bits (152), Expect = 3e-10
Identities = 72/296 (24%), Positives = 124/296 (41%), Gaps = 55/296 (18%)
Query: 33 GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQE 91
G +++ V P AE+ + GDR++ VNGV++EG TH Q V+ ++ GQ L++++
Sbjct: 1394 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT-GQVVHLLLEKG 1452
Query: 92 TDEELRRR-----QLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRE 146
+ Q T +++ AQ P D++ ++ K
Sbjct: 1453 QSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVK--------- 1503
Query: 147 LRPRLCHLRKGPQGYGFNL-HSDKSRPGQY------IRSVDPGSPAARSG-LRAQDRLIE 198
L K G GF+ D P Q ++ + PG PAA SG + D +++
Sbjct: 1504 -------LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1556
Query: 199 VNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTN 258
VNG +++GL EV+++++ E LL+ P V P ++ L +P+
Sbjct: 1557 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG-------VLP---EIDTALLTPL-- 1604
Query: 259 GTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKAR 314
SPAQ+ LP S KD+ S +Q + + + K +R
Sbjct: 1605 -QSPAQV-----------LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1648
Score = 48.5 bits (114), Expect = 8e-06
Identities = 34/94 (36%), Positives = 51/94 (54%), Gaps = 6/94 (6%)
Query: 20 GYGFHL-HGEKGRR---GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQ 74
G GF + GEK R G FI V PG PA+ L+ GDRL+ VN V++EG +HH ++
Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162
Query: 75 RIK-AVEGQTRLLVVDQETDEELRRRQLTCTEEM 107
++ A E T ++ +E ++ + T EM
Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEM 1196
Score = 45.1 bits (105), Expect = 9e-05
Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 10/110 (9%)
Query: 140 VSGPLRELRPRLCHLRKGPQ-GYGFNLHSDKSRP----GQYIRSVDPGSPAARSG-LRAQ 193
VS P RE+ L +L+K + G GF + + G +I SV PG PA G L+
Sbjct: 1084 VSSPEREIT--LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1141
Query: 194 DRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
DRLI VN ++EG+ H + ++ ++ L++ P+ E ++ TP
Sbjct: 1142 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK--EKISKVPSTP 1189
Score = 38.1 bits (87), Expect = 0.011
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 11 LCRLVRGEQG-YGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETH 69
L L++ E+G GF + R G ++ V L+ GDRL++VN +V TH
Sbjct: 1788 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTH 1847
Query: 70 HQVVQRIKAVEGQTRLLV 87
V ++A RL++
Sbjct: 1848 TDAVNLLRAASKTVRLVI 1865
Score = 37.0 bits (84), Expect = 0.025
Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 26/140 (18%)
Query: 112 LPPAHDP---WEPKPDWAHTGS-------HSSEAGKKDVSGPLR--------------EL 147
LPP P ++P+ + A + S H SE +++ PL+ EL
Sbjct: 1728 LPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVEL 1787
Query: 148 RPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
L KG GF + R G Y+ V + L+ DRLI+VN +V +
Sbjct: 1788 LITLIKSEKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM 1845
Query: 208 RHAEVVASIKAREDEARLLV 227
H + V ++A RL++
Sbjct: 1846 THTDAVNLLRAASKTVRLVI 1865
>gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform
2 [Homo sapiens]
Length = 2466
Score = 63.2 bits (152), Expect = 3e-10
Identities = 72/296 (24%), Positives = 124/296 (41%), Gaps = 55/296 (18%)
Query: 33 GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQE 91
G +++ V P AE+ + GDR++ VNGV++EG TH Q V+ ++ GQ L++++
Sbjct: 1375 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNT-GQVVHLLLEKG 1433
Query: 92 TDEELRRR-----QLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLRE 146
+ Q T +++ AQ P D++ ++ K
Sbjct: 1434 QSPTSKEHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVK--------- 1484
Query: 147 LRPRLCHLRKGPQGYGFNL-HSDKSRPGQY------IRSVDPGSPAARSG-LRAQDRLIE 198
L K G GF+ D P Q ++ + PG PAA SG + D +++
Sbjct: 1485 -------LFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILK 1537
Query: 199 VNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPLPSPVTN 258
VNG +++GL EV+++++ E LL+ P V P ++ L +P+
Sbjct: 1538 VNGASLKGLSQQEVISALRGTAPEVFLLLCRPPPG-------VLP---EIDTALLTPL-- 1585
Query: 259 GTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWKQDPFQESGLHLSPTAAEAKEKAR 314
SPAQ+ LP S KD+ S +Q + + + K +R
Sbjct: 1586 -QSPAQV-----------LPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSR 1629
Score = 48.5 bits (114), Expect = 8e-06
Identities = 34/94 (36%), Positives = 51/94 (54%), Gaps = 6/94 (6%)
Query: 20 GYGFHL-HGEKGRR---GQFIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGETHHQVVQ 74
G GF + GEK R G FI V PG PA+ L+ GDRL+ VN V++EG +HH ++
Sbjct: 1084 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1143
Query: 75 RIK-AVEGQTRLLVVDQETDEELRRRQLTCTEEM 107
++ A E T ++ +E ++ + T EM
Sbjct: 1144 ILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEM 1177
Score = 45.1 bits (105), Expect = 9e-05
Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 10/110 (9%)
Query: 140 VSGPLRELRPRLCHLRKGPQ-GYGFNLHSDKSRP----GQYIRSVDPGSPAARSG-LRAQ 193
VS P RE+ L +L+K + G GF + + G +I SV PG PA G L+
Sbjct: 1065 VSSPEREIT--LVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPG 1122
Query: 194 DRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
DRLI VN ++EG+ H + ++ ++ L++ P+ E ++ TP
Sbjct: 1123 DRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPK--EKISKVPSTP 1170
Score = 38.1 bits (87), Expect = 0.011
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 1/78 (1%)
Query: 11 LCRLVRGEQG-YGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVEVNGVNVEGETH 69
L L++ E+G GF + R G ++ V L+ GDRL++VN +V TH
Sbjct: 1769 LITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNMTH 1828
Query: 70 HQVVQRIKAVEGQTRLLV 87
V ++A RL++
Sbjct: 1829 TDAVNLLRAASKTVRLVI 1846
Score = 37.0 bits (84), Expect = 0.025
Identities = 36/140 (25%), Positives = 57/140 (40%), Gaps = 26/140 (18%)
Query: 112 LPPAHDP---WEPKPDWAHTGS-------HSSEAGKKDVSGPLR--------------EL 147
LPP P ++P+ + A + S H SE +++ PL+ EL
Sbjct: 1709 LPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLEDFELEVEL 1768
Query: 148 RPRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGL 207
L KG GF + R G Y+ V + L+ DRLI+VN +V +
Sbjct: 1769 LITLIKSEKG--SLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM 1826
Query: 208 RHAEVVASIKAREDEARLLV 227
H + V ++A RL++
Sbjct: 1827 THTDAVNLLRAASKTVRLVI 1846
>gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens]
Length = 1356
Score = 62.8 bits (151), Expect = 4e-10
Identities = 58/218 (26%), Positives = 108/218 (49%), Gaps = 30/218 (13%)
Query: 13 RLVRGEQGYGFHLHGEK----GRRGQFIRRVEP-GSPAEAAALRAGDRLVEVNGVNVEGE 67
+L +G +G GF + G +++ + P G+ + L+AGDRL+EVNGV++ G+
Sbjct: 463 QLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGK 522
Query: 68 THHQVVQRIKA--VEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDW 125
+ +VV +++ +EG LLV QE + R+L E +Q +P + D
Sbjct: 523 SQEEVVSLLRSTKMEGTVSLLVFRQE--DAFHPRELNA--EPSQMQIPK--ETKAEDEDI 576
Query: 126 AHTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHSDKSRP-----GQYIRSVD 180
T + E +V PL + G G G ++ ++S+ G +++S+
Sbjct: 577 VLTPDGTREFLTFEV--PLND---------SGSAGLGVSVKGNRSKENHADLGIFVKSII 625
Query: 181 PGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
G A++ G LR D+LI VNG+++ G + + + +++
Sbjct: 626 NGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLR 663
Score = 48.5 bits (114), Expect = 8e-06
Identities = 34/102 (33%), Positives = 54/102 (52%), Gaps = 7/102 (6%)
Query: 154 LRKGPQGYGFNLHSDKSRPGQ----YIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLR 208
L+KG +G GF++ S G Y++++ P A + G L+A DRLIEVNG ++ G
Sbjct: 464 LKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKS 523
Query: 209 HAEVVASIKA--REDEARLLVVDPETDEHFKRLRVTPTEEHV 248
EVV+ +++ E LLV E H + L P++ +
Sbjct: 524 QEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELNAEPSQMQI 565
Score = 35.0 bits (79), Expect = 0.095
Identities = 25/107 (23%), Positives = 52/107 (48%), Gaps = 15/107 (14%)
Query: 17 GEQGYGFHLHGEKGRR-----GQFIRRV-EPGSPAEAAALRAGDRLVEVNGVNVEGETHH 70
G G G + G + + G F++ + G+ ++ LR D+L+ VNG ++ G+T+
Sbjct: 597 GSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQ 656
Query: 71 ---QVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPP 114
+ ++R + EG R ++ + + R+++ E+ G PP
Sbjct: 657 DAMETLRRSMSTEGNKRGMI------QLIVARRISKCNELKSPGSPP 697
>gi|87196343 PDZ domain containing 2 [Homo sapiens]
Length = 2839
Score = 61.2 bits (147), Expect = 1e-09
Identities = 59/201 (29%), Positives = 92/201 (45%), Gaps = 15/201 (7%)
Query: 19 QGYGFHLHGEK----GRRGQFIRRVEP-GSPAEAAALRAGDRLVEVNGVNVEGETHHQVV 73
+G GF + G + G+ G F++ + P GS AE L+ GD +++VNG+ ++G T + +
Sbjct: 595 KGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAI 654
Query: 74 QRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHSS 133
K + +L V + T T M++ P + + GS SS
Sbjct: 655 HTFKQIRSGLFVLTVRTKLVSPSLTPCSTPT-HMSRSASPNFNTSGGASAGGSDEGS-SS 712
Query: 134 EAGKKDVSGPLRELRPRLCHLRKGPQGYGFN---LHSDKSRPGQYIRSVDPGSPA-ARSG 189
G+K GP + + ++ G G L + S PG YI S+ PGS A S
Sbjct: 713 SLGRK-TPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESN 771
Query: 190 LRAQDRLIEVNGQNVEGLRHA 210
L D+++EVN NV RHA
Sbjct: 772 LSRGDQILEVNSVNV---RHA 789
Score = 45.4 bits (106), Expect = 7e-05
Identities = 48/212 (22%), Positives = 88/212 (41%), Gaps = 16/212 (7%)
Query: 73 VQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSHS 132
V R+++VE L+V + + R R L + + + LP D ++ +
Sbjct: 509 VHRLESVEEYNELMVRNGDP----RIRMLEVSRDGRKHSLPQLLDSSSASQEYHIVKKST 564
Query: 133 SEAGKKDVSGPLRELRPRLCHL----RKGPQGYGFNLHSDKS----RPGQYIRSVDPGSP 184
V P R +RP + + ++ +G GF++ + + G +++++ P
Sbjct: 565 RSLSTTQVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGS 624
Query: 185 AARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTP 243
AA G L+ D +++VNG ++GL E + + K + + L V+ T L
Sbjct: 625 AAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFK--QIRSGLFVLTVRTKLVSPSLTPCS 682
Query: 244 TEEHVEGPLPSPVTNGTSPAQLNGGSACSSRS 275
T H+ SP N + A G SS S
Sbjct: 683 TPTHMSRS-ASPNFNTSGGASAGGSDEGSSSS 713
Score = 37.0 bits (84), Expect = 0.025
Identities = 32/135 (23%), Positives = 57/135 (42%), Gaps = 16/135 (11%)
Query: 14 LVRGEQGYGFHLHGEKGRRGQ----FIRRVEPGSPAEA-AALRAGDRLVEVNGVNVEGET 68
L++ G G + G +G + + +V+ G A L GD L+ +NG + G +
Sbjct: 337 LLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLS 396
Query: 69 HHQVVQRIKAVEGQTRLLVVDQETD-EELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAH 127
H + V +++ G +L+V +E E+L R + + LP E W
Sbjct: 397 HEEAVAILRSATGMVQLVVASKENSAEDLLR--------LTSKSLPDLTSSVEDVSSW-- 446
Query: 128 TGSHSSEAGKKDVSG 142
T + EA ++ G
Sbjct: 447 TDNEDQEADGEEDEG 461
Score = 34.3 bits (77), Expect = 0.16
Identities = 28/84 (33%), Positives = 41/84 (48%), Gaps = 7/84 (8%)
Query: 11 LC-RLVRGEQGYGFHLHGEK----GRRGQFIRRVEPGSPAEAAAL-RAGDRLVEVNGVNV 64
LC +++ G G L G K G I+RV G AE A + AGD ++ +NG +
Sbjct: 2749 LCVEVLKTSAGLGLSLDGGKSSVTGDGPLVIKRVYKGGAAEQAGIIEAGDEILAINGKPL 2808
Query: 65 EGETHHQVVQRIKAV-EGQTRLLV 87
G H +K+V EG +LL+
Sbjct: 2809 VGLMHFDAWNIMKSVPEGPVQLLI 2832
Score = 33.5 bits (75), Expect = 0.28
Identities = 37/125 (29%), Positives = 51/125 (40%), Gaps = 14/125 (11%)
Query: 121 PKPDWAHTGSHS----SEAGKKDVSGP---LRELRPRL--CHLRKGPQGYGFNLH----S 167
PK D T S+ S+ GK D RE R+ L K G G + S
Sbjct: 295 PKTDAPLTTSNDKRRFSKGGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGS 354
Query: 168 DKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLL 226
+S + V G A R G L D L+ +NG + GL H E VA +++ +L+
Sbjct: 355 KRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLV 414
Query: 227 VVDPE 231
V E
Sbjct: 415 VASKE 419
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 60.8 bits (146), Expect = 2e-09
Identities = 55/216 (25%), Positives = 89/216 (41%), Gaps = 14/216 (6%)
Query: 13 RLVRGEQGYGFHLHGEKGRRG-------QFIRRVEPGSPAEAAALRAGDRLVEVNGVNVE 65
+L++G +G GF + G G + + +E G+ + L+ GD+L+ VN V +E
Sbjct: 321 KLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380
Query: 66 GETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDW 125
TH + V +K L V + + ++ P + P
Sbjct: 381 EVTHEEAVTALKNTSDFVYLKVAKPTS---MYMNDGYAPPDITNSSSQPVDNHVSPSSFL 437
Query: 126 AHTGSHSSEAG--KKDVSGPLRELR-PRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPG 182
T + + K V G R PR L +G G GFN+ + G +I + G
Sbjct: 438 GQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAG 497
Query: 183 SPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
PA SG LR DR+I VN ++ H + A++K
Sbjct: 498 GPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
Score = 50.8 bits (120), Expect = 2e-06
Identities = 31/90 (34%), Positives = 45/90 (50%), Gaps = 2/90 (2%)
Query: 9 PRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGE 67
PR L RG G GF++ G + G FI + G PA+ + LR GDR++ VN V++
Sbjct: 464 PRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAA 523
Query: 68 THHQVVQRIKAVEGQTRLLVVDQETDEELR 97
+H Q +K GQ +V +E R
Sbjct: 524 SHEQAAAALKNA-GQAVTIVAQYRPEEYSR 552
Score = 50.4 bits (119), Expect = 2e-06
Identities = 67/273 (24%), Positives = 101/273 (36%), Gaps = 70/273 (25%)
Query: 14 LVRGEQGYGFHLHGEKGR------RGQFIRRV-EPGSPAEAAALRAGDRLVEVNGVNVEG 66
L RG G GF + G FI ++ G+ A+ LR D ++ VN V+V
Sbjct: 227 LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286
Query: 67 ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
TH + V+ +K RL V +RR
Sbjct: 287 VTHSKAVEALKEAGSIVRLYV---------KRR--------------------------- 310
Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHS---DKSRPGQ---YIRSVD 180
K VS + E++ L KGP+G GF++ ++ PG Y+ +
Sbjct: 311 -----------KPVSEKIMEIK-----LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKII 354
Query: 181 PGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRL 239
G A + G L+ D+L+ VN +E + H E V ++K D L V P T +
Sbjct: 355 EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKP-TSMYMNDG 413
Query: 240 RVTPTEEHVEGPLPSPVTNGTSPAQLNGGSACS 272
P + PV N SP+ G + S
Sbjct: 414 YAPP---DITNSSSQPVDNHVSPSSFLGQTPAS 443
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 60.8 bits (146), Expect = 2e-09
Identities = 55/216 (25%), Positives = 89/216 (41%), Gaps = 14/216 (6%)
Query: 13 RLVRGEQGYGFHLHGEKGRRG-------QFIRRVEPGSPAEAAALRAGDRLVEVNGVNVE 65
+L++G +G GF + G G + + +E G+ + L+ GD+L+ VN V +E
Sbjct: 321 KLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLE 380
Query: 66 GETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDW 125
TH + V +K L V + + ++ P + P
Sbjct: 381 EVTHEEAVTALKNTSDFVYLKVAKPTS---MYMNDGYAPPDITNSSSQPVDNHVSPSSFL 437
Query: 126 AHTGSHSSEAG--KKDVSGPLRELR-PRLCHLRKGPQGYGFNLHSDKSRPGQYIRSVDPG 182
T + + K V G R PR L +G G GFN+ + G +I + G
Sbjct: 438 GQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAG 497
Query: 183 SPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIK 217
PA SG LR DR+I VN ++ H + A++K
Sbjct: 498 GPADLSGELRKGDRIISVNSVDLRAASHEQAAAALK 533
Score = 50.8 bits (120), Expect = 2e-06
Identities = 31/90 (34%), Positives = 45/90 (50%), Gaps = 2/90 (2%)
Query: 9 PRLCRLVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAA-LRAGDRLVEVNGVNVEGE 67
PR L RG G GF++ G + G FI + G PA+ + LR GDR++ VN V++
Sbjct: 464 PRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAA 523
Query: 68 THHQVVQRIKAVEGQTRLLVVDQETDEELR 97
+H Q +K GQ +V +E R
Sbjct: 524 SHEQAAAALKNA-GQAVTIVAQYRPEEYSR 552
Score = 50.4 bits (119), Expect = 2e-06
Identities = 67/273 (24%), Positives = 101/273 (36%), Gaps = 70/273 (25%)
Query: 14 LVRGEQGYGFHLHGEKGR------RGQFIRRV-EPGSPAEAAALRAGDRLVEVNGVNVEG 66
L RG G GF + G FI ++ G+ A+ LR D ++ VN V+V
Sbjct: 227 LERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRD 286
Query: 67 ETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWA 126
TH + V+ +K RL V +RR
Sbjct: 287 VTHSKAVEALKEAGSIVRLYV---------KRR--------------------------- 310
Query: 127 HTGSHSSEAGKKDVSGPLRELRPRLCHLRKGPQGYGFNLHS---DKSRPGQ---YIRSVD 180
K VS + E++ L KGP+G GF++ ++ PG Y+ +
Sbjct: 311 -----------KPVSEKIMEIK-----LIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKII 354
Query: 181 PGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRL 239
G A + G L+ D+L+ VN +E + H E V ++K D L V P T +
Sbjct: 355 EGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKP-TSMYMNDG 413
Query: 240 RVTPTEEHVEGPLPSPVTNGTSPAQLNGGSACS 272
P + PV N SP+ G + S
Sbjct: 414 YAPP---DITNSSSQPVDNHVSPSSFLGQTPAS 443
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 60.8 bits (146), Expect = 2e-09
Identities = 67/263 (25%), Positives = 105/263 (39%), Gaps = 42/263 (15%)
Query: 2 AAPEPLRPRLCRLVRGE-QGYGFHLHGEKGRRG-----QFIRRVEPGSPAEAAA-LRAGD 54
A P P P L R E +G+GF + K + I RV GSPA+ L+ GD
Sbjct: 842 ARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGD 901
Query: 55 RLVEVNGVNVEGETHHQVVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPP 114
+ VNG ++ +H +VQ IK L V+ +E + + A + P
Sbjct: 902 HISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPM 961
Query: 115 AHDPWEPKPDWAHTGSHSSEAGK--KDVSGPLRELRPRLCHL------------------ 154
P G S+ G+ KDVS R HL
Sbjct: 962 GQSQANHIP-----GDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQN 1016
Query: 155 --------RKGPQGYGFNLHSDKS-RPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNV 204
+GP+G+GF+L K G +I + PA + G + D+++E+NG+
Sbjct: 1017 LGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPT 1076
Query: 205 EGLRHAEVVASIKAREDEARLLV 227
+G+ H + I+A ++ LL+
Sbjct: 1077 QGITHTRAIELIQAGGNKVLLLL 1099
Score = 57.4 bits (137), Expect = 2e-08
Identities = 75/287 (26%), Positives = 121/287 (42%), Gaps = 42/287 (14%)
Query: 14 LVRGEQGYGFHLHGEKGR-RGQFIRRVEP-GSPAEAAALRAGDRLVEVNGVNVEGETHHQ 71
L + E G+GF + G G + +I + P G+ + LRA D L+ ++G+ V+G++H Q
Sbjct: 729 LRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQ 788
Query: 72 VVQRIKAVEGQTRLLVVDQETDEELRRRQLTCTEEMAQRGLPPAHDPWEPKPDWAHTGSH 131
V+ + +L+ RR++ E+ + A + T +
Sbjct: 789 VLDLMTTAARNGHVLLTV--------RRKIFYGEKQPEDDSSQA---------FISTQNG 831
Query: 132 SSEAGKKDVSGPLRELRPRLCHL-RKGPQGYGFNLHSDKSRPG-----QYIRSVDPGSPA 185
S + +V P L RK +G+GF + + K++P I V GSPA
Sbjct: 832 SPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPA 891
Query: 186 ARSG-LRAQDRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDPETDEHFKRLRVTPT 244
R G L+ D + VNGQ++ L H +V IK +A + V L V
Sbjct: 892 DRCGKLKVGDHISAVNGQSIVELSHDNIVQLIK----DAGVTVT----------LTVIAE 937
Query: 245 EEHVEGPLPSPVTNGTSPAQLNGGSACSSRSDLPGSDKDTEDGSAWK 291
EEH GP + SPA + S + +PG D+ +G K
Sbjct: 938 EEH-HGPPSGTNSARQSPALQHRPMGQSQANHIPG-DRSALEGEIGK 982
Score = 45.4 bits (106), Expect = 7e-05
Identities = 62/236 (26%), Positives = 99/236 (41%), Gaps = 34/236 (14%)
Query: 1 MAAPEPLRPRLCR--LVRGEQGYGFHLHGEKGRRGQFIRRVEPGSPAEAAALRAGDRLVE 58
MA+ +P L L++G +G+GF + GQ ++ + + L+ GD + E
Sbjct: 566 MASSGSSQPELVTIPLIKGPKGFGFAIADSP--TGQKVKMILDSQWCQG--LQKGDIIKE 621
Query: 59 VNGVNVEGETHHQVVQRIK--AVEGQTRLLVV-----------DQETDEELRRRQLTCTE 105
+ NV+ TH QVV+ +K V LL++ +TD++ L
Sbjct: 622 IYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAIN 681
Query: 106 EMAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDV-SGPLRELRPRL-----CHLRKGPQ 159
E P P P +GS + + + S L E +P LRK
Sbjct: 682 E-------PIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQES 734
Query: 160 GYGFN-LHSDKSRPGQYIRSVDPGSPAARSG-LRAQDRLIEVNGQNVEGLRHAEVV 213
G+GF L D YI ++ P A + G LRA D L+ ++G V+G H +V+
Sbjct: 735 GFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVL 790
Score = 43.1 bits (100), Expect = 3e-04
Identities = 64/245 (26%), Positives = 98/245 (40%), Gaps = 36/245 (14%)
Query: 4 PEPLRPRLCR--LVRGEQGYGFHLHGEKGRRGQFIRR---VEPGSPAEAAALRAGDRLVE 58
P L+ L R L + G+GF + G R +F++ ++ G A+ + GD +V+
Sbjct: 401 PSQLKGVLVRASLKKSTMGFGFTIIGGD-RPDEFLQVKNVLKDGPAAQDGKIAPGDVIVD 459
Query: 59 VNGVNVEGETHHQVVQRIKAVEGQTRL---------LVVDQE--------TDEELRRRQL 101
+NG V G TH VVQ + V + L D E + + L
Sbjct: 460 INGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSL 519
Query: 102 TCTEE-MAQRGLPPAHDPWEPKPDWAHTGSHSSEAGKKDVSGPLREL------RPRL--C 152
T E M + P E HT + G D S + +P L
Sbjct: 520 TKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTI 579
Query: 153 HLRKGPQGYGFNLHSDKSRPGQYIRSVDPGSPAARSGLRAQDRLIEVNGQNVEGLRHAEV 212
L KGP+G+GF + S GQ ++ + GL+ D + E+ QNV+ L H +V
Sbjct: 580 PLIKGPKGFGFAIAD--SPTGQKVKMILDSQWC--QGLQKGDIIKEIYHQNVQNLTHLQV 635
Query: 213 VASIK 217
V +K
Sbjct: 636 VEVLK 640
Score = 37.4 bits (85), Expect = 0.019
Identities = 38/136 (27%), Positives = 60/136 (44%), Gaps = 22/136 (16%)
Query: 154 LRKGPQGYGFNLHSDKSRPGQY--IRSVDPGSPAARSGLRAQ-DRLIEVNGQNVEGLRHA 210
L+K G+GF + RP ++ +++V PAA+ G A D ++++NG V G HA
Sbjct: 413 LKKSTMGFGFTIIGG-DRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHA 471
Query: 211 EVVASIKAREDEARLLVVDPETDEHFKRLRVTPTEEHVEGPL-----PSPVTNGTSPAQL 265
+VV + +V + R P + E P+ +PV NG S L
Sbjct: 472 DVVQMFQ---------LVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQS---L 519
Query: 266 NGGSACSSRSDL-PGS 280
G C + D PG+
Sbjct: 520 TKGETCMNPQDFKPGA 535
Score = 28.9 bits (63), Expect = 6.8
Identities = 15/37 (40%), Positives = 21/37 (56%)
Query: 194 DRLIEVNGQNVEGLRHAEVVASIKAREDEARLLVVDP 230
D L+EVNG V GL + + +A I+ + RL V P
Sbjct: 69 DVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKP 105
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,490,821
Number of Sequences: 37866
Number of extensions: 813210
Number of successful extensions: 2679
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 179
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 2030
Number of HSP's gapped (non-prelim): 564
length of query: 337
length of database: 18,247,518
effective HSP length: 103
effective length of query: 234
effective length of database: 14,347,320
effective search space: 3357272880
effective search space used: 3357272880
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.