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Search of human proteins with 190194360
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190194360 protocadherin 20 [Homo sapiens]
(951 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190194360 protocadherin 20 [Homo sapiens] 1899 0.0
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 656 0.0
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 656 0.0
gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo s... 628 e-180
gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens] 628 e-180
gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens] 628 e-180
gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo ... 628 e-180
gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens] 623 e-178
gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens] 623 e-178
gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens] 623 e-178
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens] 436 e-122
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens] 436 e-122
gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens] 405 e-113
gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens] 405 e-113
gi|14589935 protocadherin 7 isoform c precursor [Homo sapiens] 369 e-102
gi|14589929 protocadherin 18 precursor [Homo sapiens] 287 3e-77
gi|14195607 protocadherin beta 1 precursor [Homo sapiens] 280 3e-75
gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precur... 280 6e-75
gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precur... 280 6e-75
gi|157426847 protocadherin 19 isoform a [Homo sapiens] 276 7e-74
gi|157426845 protocadherin 19 isoform b [Homo sapiens] 276 7e-74
gi|94538350 protocadherin 17 precursor [Homo sapiens] 275 1e-73
gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precurs... 275 2e-73
gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precur... 275 2e-73
gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precurs... 274 3e-73
gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precurs... 274 3e-73
gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precurso... 273 6e-73
gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precurs... 273 6e-73
gi|11128029 protocadherin gamma subfamily B, 6 isoform 1 precurs... 272 9e-73
gi|14270502 protocadherin gamma subfamily B, 6 isoform 2 precurs... 272 9e-73
>gi|190194360 protocadherin 20 [Homo sapiens]
Length = 951
Score = 1899 bits (4920), Expect = 0.0
Identities = 951/951 (100%), Positives = 951/951 (100%)
Query: 1 MRGRGNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLG 60
MRGRGNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLG
Sbjct: 1 MRGRGNARSSQALGVSWCPATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLG 60
Query: 61 SYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFS 120
SYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFS
Sbjct: 61 SYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFS 120
Query: 121 LASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLL 180
LASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLL
Sbjct: 121 LASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLL 180
Query: 181 DVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVG 240
DVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVG
Sbjct: 181 DVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVG 240
Query: 241 INGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPL 300
INGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPL
Sbjct: 241 INGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPL 300
Query: 301 LGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYS 360
LGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYS
Sbjct: 301 LGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYS 360
Query: 361 QKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVI 420
QKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVI
Sbjct: 361 QKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVI 420
Query: 421 FRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPY 480
FRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPY
Sbjct: 421 FRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPY 480
Query: 481 KPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLI 540
KPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLI
Sbjct: 481 KPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLI 540
Query: 541 ELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDRE 600
ELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDRE
Sbjct: 541 ELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGILTVSTQLDRE 600
Query: 601 EKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGV 660
EKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGV
Sbjct: 601 EKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGV 660
Query: 661 ISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEP 720
ISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEP
Sbjct: 661 ISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEP 720
Query: 721 ALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVI 780
ALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVI
Sbjct: 721 ALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVI 780
Query: 781 AYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVN 840
AYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVN
Sbjct: 781 AYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVN 840
Query: 841 LFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTLVALSVISLGS 900
LFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTLVALSVISLGS
Sbjct: 841 LFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTLVALSVISLGS 900
Query: 901 ITLVTGMGIYICLRKGEKHPREDENLEVQIPLKGKIDLHMRERKPMDISNI 951
ITLVTGMGIYICLRKGEKHPREDENLEVQIPLKGKIDLHMRERKPMDISNI
Sbjct: 901 ITLVTGMGIYICLRKGEKHPREDENLEVQIPLKGKIDLHMRERKPMDISNI 951
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 656 bits (1692), Expect = 0.0
Identities = 364/823 (44%), Positives = 507/823 (61%), Gaps = 36/823 (4%)
Query: 49 FFLFVGPFSCLGSYSR-ATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPE 107
F+L +CL S A EL+Y++ E LP V IG++ +DL + S +
Sbjct: 6 FYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNI-----------SHINA 54
Query: 108 RTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVS 167
TG + L + L S+ V + + +GE+ T++ IDRE LC
Sbjct: 55 ATGT--SASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCA------------G 100
Query: 168 ISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTR 227
S + + C L+V++LP ++FR +K+KI ++D NDNAP FP I++ +PEN +N+R
Sbjct: 101 ASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSR 160
Query: 228 LAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYV 287
I A DPD G NGVQ Y LL+ +F LD+ E GE+ P LIV LDRE +D YV
Sbjct: 161 FPIPS-ATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYV 219
Query: 288 SIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDK 347
I EDGG+P +A L + +SD+NDN P+F + Q+ V + NA VGT + + A D
Sbjct: 220 MKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDA 279
Query: 348 DLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIP 407
D+G+NA+I Y + +V A+K LF L+ TG+I + + HK+T+LA+ P
Sbjct: 280 DIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP 339
Query: 408 AVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTI--RDPEGKYKV 465
A T +++ V PP I RYI + I+G VYL E +PVNT IA T+ +D + KV
Sbjct: 340 ARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV 399
Query: 466 NCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKV 523
C+++ E PF L Y+N+YLLET+ +DYE + + +VA +S + +++V
Sbjct: 400 ICFIEREVPFHLKAV--YDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRV 457
Query: 524 QLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFS 583
+L D+NDN PIF QP+IEL++ ENN +LT + ATD DS + + Y LGP+A S+F
Sbjct: 458 KLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFD 516
Query: 584 LDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKD 643
LD TG+LT S DREE+E++ +TV A D G PP +S A V +TVLD+NDNSP+F +
Sbjct: 517 LDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNH 576
Query: 644 FSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDRE 703
F FFV EN P Y +GVI+VTDADAG N V LS++N +D FV+D G++++ VS DRE
Sbjct: 577 FQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDRE 636
Query: 704 QQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSP 763
QQSSYT V+A DGG+P SSTAK+TI ++D+NDN P+V+ P SN S+ LV S +PGS
Sbjct: 637 QQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSV 696
Query: 764 VTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVK 823
V EV+AVD DTGMNA + Y+I+ G FRIDP TGNITLEE TD GLHRL+V
Sbjct: 697 VAEVFAVDVDTGMNAELKYTIVS--GNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVN 754
Query: 824 VSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIE 866
+SD GYP+ LH+ V+V L+VNDT N SYI L+R+ E ++
Sbjct: 755 ISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLD 797
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 656 bits (1692), Expect = 0.0
Identities = 364/823 (44%), Positives = 507/823 (61%), Gaps = 36/823 (4%)
Query: 49 FFLFVGPFSCLGSYSR-ATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPE 107
F+L +CL S A EL+Y++ E LP V IG++ +DL + S +
Sbjct: 6 FYLLAALIACLRLDSAIAQELIYTIREELPENVPIGNIPKDLNI-----------SHINA 54
Query: 108 RTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVS 167
TG + L + L S+ V + + +GE+ T++ IDRE LC
Sbjct: 55 ATGT--SASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCA------------G 100
Query: 168 ISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTR 227
S + + C L+V++LP ++FR +K+KI ++D NDNAP FP I++ +PEN +N+R
Sbjct: 101 ASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSR 160
Query: 228 LAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYV 287
I A DPD G NGVQ Y LL+ +F LD+ E GE+ P LIV LDRE +D YV
Sbjct: 161 FPIPS-ATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYV 219
Query: 288 SIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDK 347
I EDGG+P +A L + +SD+NDN P+F + Q+ V + NA VGT + + A D
Sbjct: 220 MKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDA 279
Query: 348 DLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIP 407
D+G+NA+I Y + +V A+K LF L+ TG+I + + HK+T+LA+ P
Sbjct: 280 DIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTP 339
Query: 408 AVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTI--RDPEGKYKV 465
A T +++ V PP I RYI + I+G VYL E +PVNT IA T+ +D + KV
Sbjct: 340 ARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKV 399
Query: 466 NCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKV 523
C+++ E PF L Y+N+YLLET+ +DYE + + +VA +S + +++V
Sbjct: 400 ICFIEREVPFHLKAV--YDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRV 457
Query: 524 QLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFS 583
+L D+NDN PIF QP+IEL++ ENN +LT + ATD DS + + Y LGP+A S+F
Sbjct: 458 KLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNA-SFFD 516
Query: 584 LDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKD 643
LD TG+LT S DREE+E++ +TV A D G PP +S A V +TVLD+NDNSP+F +
Sbjct: 517 LDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNH 576
Query: 644 FSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDRE 703
F FFV EN P Y +GVI+VTDADAG N V LS++N +D FV+D G++++ VS DRE
Sbjct: 577 FQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDRE 636
Query: 704 QQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSP 763
QQSSYT V+A DGG+P SSTAK+TI ++D+NDN P+V+ P SN S+ LV S +PGS
Sbjct: 637 QQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSV 696
Query: 764 VTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVK 823
V EV+AVD DTGMNA + Y+I+ G FRIDP TGNITLEE TD GLHRL+V
Sbjct: 697 VAEVFAVDVDTGMNAELKYTIVS--GNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVN 754
Query: 824 VSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIE 866
+SD GYP+ LH+ V+V L+VNDT N SYI L+R+ E ++
Sbjct: 755 ISDLGYPKSLHTLVLVFLYVNDTAGNASYIYDLIRRTMETPLD 797
>gi|7657443 protocadherin 11 X-linked isoform a precursor [Homo
sapiens]
Length = 1021
Score = 628 bits (1620), Expect = e-180
Identities = 347/820 (42%), Positives = 506/820 (61%), Gaps = 43/820 (5%)
Query: 50 FLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRL--LPRSAGRPDPQSQLPE 107
++F +C+ +S A E Y++ E +P VLIG L +DL L +P + Q +L
Sbjct: 8 YIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVY 67
Query: 108 RTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVS 167
+TG + PL + ++ +GE+ T+ IDRE LC
Sbjct: 68 KTG---DVPL-------------IRIEEDTGEIFTTGARIDREKLC-------------- 97
Query: 168 ISSSPSDS-CLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNT 226
+ P D C ++V +LP E FR VK++ I DINDNAP FP + I++ +PEN+ +N+
Sbjct: 98 -AGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINS 156
Query: 227 RLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQY 286
+ + AVDPDVGINGVQ Y L+ +F LDV E G++ P LIV LDRE +D Y
Sbjct: 157 KYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTY 215
Query: 287 VSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVD 346
V + EDGG P +A L + ++D NDN P+F +++I V++ NA VGT + + A D
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 347 KDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCI 406
D+G NA+I +S+S V ++ LFHL+ TG+I + + +HKL +LA+ G +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM 335
Query: 407 PAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKY--K 464
PA LV++ V P I RYI N ++ V L E P+NT IA T+ D + + +
Sbjct: 336 PARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGR 395
Query: 465 VNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIK 522
V C+ D E PFRL P ++N++LLET +DYE + Y + ++A ++ + ++
Sbjct: 396 VTCFTDHEIPFRLRPV--FSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF 453
Query: 523 VQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYF 582
+++ D+NDNAP+F Q + ++I ENNSP LTK+ A DADS +++Y LGPDAP F
Sbjct: 454 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEF 513
Query: 583 SLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINK 642
SLD TG+LTV +LDRE+++KY +T+ A D G PP S TV ++++D+NDNSP F +
Sbjct: 514 SLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHN 573
Query: 643 DFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDR 702
+++F+VPEN P +G +G+I+VTD D G N V LS+++++D F ID+ G++R +S DR
Sbjct: 574 EYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDR 633
Query: 703 EQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGS 762
E+Q SYT +V+A DGG + SS+AK+TI ++D+NDN P+ + P SN SY LVLPST PG+
Sbjct: 634 EKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT 693
Query: 763 PVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLV 822
V +V AVD DTGMNA + YSI+G G + F ID +TGNITL E TD GLHR+LV
Sbjct: 694 VVFQVIAVDNDTGMNAEVRYSIVG--GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLV 751
Query: 823 KVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
K +D G P+ L S V+VNLFVN++V+N + I L+RK E
Sbjct: 752 KANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
>gi|14589922 protocadherin 11 X-linked isoform d [Homo sapiens]
Length = 1337
Score = 628 bits (1620), Expect = e-180
Identities = 347/820 (42%), Positives = 506/820 (61%), Gaps = 43/820 (5%)
Query: 50 FLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRL--LPRSAGRPDPQSQLPE 107
++F +C+ +S A E Y++ E +P VLIG L +DL L +P + Q +L
Sbjct: 8 YIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVY 67
Query: 108 RTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVS 167
+TG + PL + ++ +GE+ T+ IDRE LC
Sbjct: 68 KTG---DVPL-------------IRIEEDTGEIFTTGARIDREKLC-------------- 97
Query: 168 ISSSPSDS-CLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNT 226
+ P D C ++V +LP E FR VK++ I DINDNAP FP + I++ +PEN+ +N+
Sbjct: 98 -AGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINS 156
Query: 227 RLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQY 286
+ + AVDPDVGINGVQ Y L+ +F LDV E G++ P LIV LDRE +D Y
Sbjct: 157 KYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTY 215
Query: 287 VSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVD 346
V + EDGG P +A L + ++D NDN P+F +++I V++ NA VGT + + A D
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 347 KDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCI 406
D+G NA+I +S+S V ++ LFHL+ TG+I + + +HKL +LA+ G +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM 335
Query: 407 PAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKY--K 464
PA LV++ V P I RYI N ++ V L E P+NT IA T+ D + + +
Sbjct: 336 PARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGR 395
Query: 465 VNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIK 522
V C+ D E PFRL P ++N++LLET +DYE + Y + ++A ++ + ++
Sbjct: 396 VTCFTDHEIPFRLRPV--FSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF 453
Query: 523 VQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYF 582
+++ D+NDNAP+F Q + ++I ENNSP LTK+ A DADS +++Y LGPDAP F
Sbjct: 454 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEF 513
Query: 583 SLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINK 642
SLD TG+LTV +LDRE+++KY +T+ A D G PP S TV ++++D+NDNSP F +
Sbjct: 514 SLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHN 573
Query: 643 DFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDR 702
+++F+VPEN P +G +G+I+VTD D G N V LS+++++D F ID+ G++R +S DR
Sbjct: 574 EYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDR 633
Query: 703 EQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGS 762
E+Q SYT +V+A DGG + SS+AK+TI ++D+NDN P+ + P SN SY LVLPST PG+
Sbjct: 634 EKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT 693
Query: 763 PVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLV 822
V +V AVD DTGMNA + YSI+G G + F ID +TGNITL E TD GLHR+LV
Sbjct: 694 VVFQVIAVDNDTGMNAEVRYSIVG--GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLV 751
Query: 823 KVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
K +D G P+ L S V+VNLFVN++V+N + I L+RK E
Sbjct: 752 KANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
>gi|14589920 protocadherin 11 X-linked isoform c [Homo sapiens]
Length = 1347
Score = 628 bits (1620), Expect = e-180
Identities = 347/820 (42%), Positives = 506/820 (61%), Gaps = 43/820 (5%)
Query: 50 FLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRL--LPRSAGRPDPQSQLPE 107
++F +C+ +S A E Y++ E +P VLIG L +DL L +P + Q +L
Sbjct: 8 YIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVY 67
Query: 108 RTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVS 167
+TG + PL + ++ +GE+ T+ IDRE LC
Sbjct: 68 KTG---DVPL-------------IRIEEDTGEIFTTGARIDREKLC-------------- 97
Query: 168 ISSSPSDS-CLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNT 226
+ P D C ++V +LP E FR VK++ I DINDNAP FP + I++ +PEN+ +N+
Sbjct: 98 -AGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINS 156
Query: 227 RLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQY 286
+ + AVDPDVGINGVQ Y L+ +F LDV E G++ P LIV LDRE +D Y
Sbjct: 157 KYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTY 215
Query: 287 VSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVD 346
V + EDGG P +A L + ++D NDN P+F +++I V++ NA VGT + + A D
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 347 KDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCI 406
D+G NA+I +S+S V ++ LFHL+ TG+I + + +HKL +LA+ G +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM 335
Query: 407 PAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKY--K 464
PA LV++ V P I RYI N ++ V L E P+NT IA T+ D + + +
Sbjct: 336 PARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGR 395
Query: 465 VNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIK 522
V C+ D E PFRL P ++N++LLET +DYE + Y + ++A ++ + ++
Sbjct: 396 VTCFTDHEIPFRLRPV--FSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF 453
Query: 523 VQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYF 582
+++ D+NDNAP+F Q + ++I ENNSP LTK+ A DADS +++Y LGPDAP F
Sbjct: 454 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEF 513
Query: 583 SLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINK 642
SLD TG+LTV +LDRE+++KY +T+ A D G PP S TV ++++D+NDNSP F +
Sbjct: 514 SLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHN 573
Query: 643 DFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDR 702
+++F+VPEN P +G +G+I+VTD D G N V LS+++++D F ID+ G++R +S DR
Sbjct: 574 EYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDR 633
Query: 703 EQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGS 762
E+Q SYT +V+A DGG + SS+AK+TI ++D+NDN P+ + P SN SY LVLPST PG+
Sbjct: 634 EKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT 693
Query: 763 PVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLV 822
V +V AVD DTGMNA + YSI+G G + F ID +TGNITL E TD GLHR+LV
Sbjct: 694 VVFQVIAVDNDTGMNAEVRYSIVG--GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLV 751
Query: 823 KVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
K +D G P+ L S V+VNLFVN++V+N + I L+RK E
Sbjct: 752 KANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
>gi|14589918 protocadherin 11 X-linked isoform b precursor [Homo
sapiens]
Length = 1025
Score = 628 bits (1620), Expect = e-180
Identities = 347/820 (42%), Positives = 506/820 (61%), Gaps = 43/820 (5%)
Query: 50 FLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRL--LPRSAGRPDPQSQLPE 107
++F +C+ +S A E Y++ E +P VLIG L +DL L +P + Q +L
Sbjct: 8 YIFAVLLACVVFHSGAQEKNYTIREEMPENVLIGDLLKDLNLSLIPNKSLTTAMQFKLVY 67
Query: 108 RTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVS 167
+TG + PL + ++ +GE+ T+ IDRE LC
Sbjct: 68 KTG---DVPL-------------IRIEEDTGEIFTTGARIDREKLC-------------- 97
Query: 168 ISSSPSDS-CLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNT 226
+ P D C ++V +LP E FR VK++ I DINDNAP FP + I++ +PEN+ +N+
Sbjct: 98 -AGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINS 156
Query: 227 RLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQY 286
+ + AVDPDVGINGVQ Y L+ +F LDV E G++ P LIV LDRE +D Y
Sbjct: 157 KYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTY 215
Query: 287 VSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVD 346
V + EDGG P +A L + ++D NDN P+F +++I V++ NA VGT + + A D
Sbjct: 216 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 275
Query: 347 KDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCI 406
D+G NA+I +S+S V ++ LFHL+ TG+I + + +HKL +LA+ G +
Sbjct: 276 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM 335
Query: 407 PAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKY--K 464
PA LV++ V P I RYI N ++ V L E P+NT IA T+ D + + +
Sbjct: 336 PARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGR 395
Query: 465 VNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIK 522
V C+ D E PFRL P ++N++LLET +DYE + Y + ++A ++ + ++
Sbjct: 396 VTCFTDHEIPFRLRPV--FSNQFLLETAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF 453
Query: 523 VQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYF 582
+++ D+NDNAP+F Q + ++I ENNSP LTK+ A DADS +++Y LGPDAP F
Sbjct: 454 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLTKVSAMDADSGPNAKINYLLGPDAPPEF 513
Query: 583 SLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINK 642
SLD TG+LTV +LDRE+++KY +T+ A D G PP S TV ++++D+NDNSP F +
Sbjct: 514 SLDCRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHN 573
Query: 643 DFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDR 702
+++F+VPEN P +G +G+I+VTD D G N V LS+++++D F ID+ G++R +S DR
Sbjct: 574 EYNFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDR 633
Query: 703 EQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGS 762
E+Q SYT +V+A DGG + SS+AK+TI ++D+NDN P+ + P SN SY LVLPST PG+
Sbjct: 634 EKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPSNCSYELVLPSTNPGT 693
Query: 763 PVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLV 822
V +V AVD DTGMNA + YSI+G G + F ID +TGNITL E TD GLHR+LV
Sbjct: 694 VVFQVIAVDNDTGMNAEVRYSIVG--GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLV 751
Query: 823 KVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
K +D G P+ L S V+VNLFVN++V+N + I L+RK E
Sbjct: 752 KANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSTE 791
>gi|14589946 protocadherin 11 Y-linked isoform c [Homo sapiens]
Length = 1340
Score = 623 bits (1606), Expect = e-178
Identities = 345/820 (42%), Positives = 503/820 (61%), Gaps = 43/820 (5%)
Query: 50 FLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRL--LPRSAGRPDPQSQLPE 107
++F C+ +S A E Y++ E +P VLIG+L +DL L +P + Q +L
Sbjct: 40 YIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVY 99
Query: 108 RTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVS 167
+TG + PL + ++ +GE+ T+ IDRE LC
Sbjct: 100 KTG---DVPL-------------IRIEEDTGEIFTTGARIDREKLC-------------- 129
Query: 168 ISSSPSDS-CLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNT 226
+ P D C ++V +LP E FR VK++ I DINDNAP FP + I++ +PEN+ +N+
Sbjct: 130 -AGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINS 188
Query: 227 RLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQY 286
+ + AVDPDVGINGVQ Y L+ +F LDV E G++ P LIV LDRE +D Y
Sbjct: 189 KYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTY 247
Query: 287 VSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVD 346
V + EDGG P +A L + ++D NDN P+F +++I V++ NA VGT + + A D
Sbjct: 248 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 307
Query: 347 KDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCI 406
D+G NA+I +S+S V ++ LFHL+ TG+I + + +HKL +LA+ G +
Sbjct: 308 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM 367
Query: 407 PAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKY--K 464
PA LV++ V P I RYI N ++ V L E P+NT IA T+ D + + +
Sbjct: 368 PARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGR 427
Query: 465 VNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIK 522
V C+ D E PFRL P ++N++LLE +DYE + Y + ++A ++ + ++
Sbjct: 428 VTCFTDHEIPFRLRPV--FSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF 485
Query: 523 VQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYF 582
+++ D+NDNAP+F Q + ++I ENNSP L K+ ATDADS +++Y LGPDAP F
Sbjct: 486 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEF 545
Query: 583 SLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINK 642
SLD TG+LTV +LDRE+++KY +T+ A D G PP S TV ++++D+NDNSP F +
Sbjct: 546 SLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHN 605
Query: 643 DFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDR 702
++ F+VPEN P +G +G+I+VTD D G N V LS+++++D F ID+ G++R +S DR
Sbjct: 606 EYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDR 665
Query: 703 EQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGS 762
E+Q SYT +V+A DGG + SS+AK+TI ++D+NDN P+ + P N SY LVLPST PG+
Sbjct: 666 EKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGT 725
Query: 763 PVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLV 822
V +V AVD DTGMNA + YSI+G G + F ID +TGNITL E TD GLHR+LV
Sbjct: 726 VVFQVIAVDNDTGMNAEVRYSIVG--GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLV 783
Query: 823 KVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
K +D G P+ L S V+VNLFVN++V+N + I L+RK E
Sbjct: 784 KANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 823
>gi|14589944 protocadherin 11 Y-linked isoform b [Homo sapiens]
Length = 1048
Score = 623 bits (1606), Expect = e-178
Identities = 345/820 (42%), Positives = 503/820 (61%), Gaps = 43/820 (5%)
Query: 50 FLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRL--LPRSAGRPDPQSQLPE 107
++F C+ +S A E Y++ E +P VLIG+L +DL L +P + Q +L
Sbjct: 40 YIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVY 99
Query: 108 RTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVS 167
+TG + PL + ++ +GE+ T+ IDRE LC
Sbjct: 100 KTG---DVPL-------------IRIEEDTGEIFTTGARIDREKLC-------------- 129
Query: 168 ISSSPSDS-CLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNT 226
+ P D C ++V +LP E FR VK++ I DINDNAP FP + I++ +PEN+ +N+
Sbjct: 130 -AGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINS 188
Query: 227 RLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQY 286
+ + AVDPDVGINGVQ Y L+ +F LDV E G++ P LIV LDRE +D Y
Sbjct: 189 KYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTY 247
Query: 287 VSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVD 346
V + EDGG P +A L + ++D NDN P+F +++I V++ NA VGT + + A D
Sbjct: 248 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 307
Query: 347 KDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCI 406
D+G NA+I +S+S V ++ LFHL+ TG+I + + +HKL +LA+ G +
Sbjct: 308 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM 367
Query: 407 PAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKY--K 464
PA LV++ V P I RYI N ++ V L E P+NT IA T+ D + + +
Sbjct: 368 PARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGR 427
Query: 465 VNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIK 522
V C+ D E PFRL P ++N++LLE +DYE + Y + ++A ++ + ++
Sbjct: 428 VTCFTDHEIPFRLRPV--FSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF 485
Query: 523 VQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYF 582
+++ D+NDNAP+F Q + ++I ENNSP L K+ ATDADS +++Y LGPDAP F
Sbjct: 486 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEF 545
Query: 583 SLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINK 642
SLD TG+LTV +LDRE+++KY +T+ A D G PP S TV ++++D+NDNSP F +
Sbjct: 546 SLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHN 605
Query: 643 DFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDR 702
++ F+VPEN P +G +G+I+VTD D G N V LS+++++D F ID+ G++R +S DR
Sbjct: 606 EYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDR 665
Query: 703 EQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGS 762
E+Q SYT +V+A DGG + SS+AK+TI ++D+NDN P+ + P N SY LVLPST PG+
Sbjct: 666 EKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGT 725
Query: 763 PVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLV 822
V +V AVD DTGMNA + YSI+G G + F ID +TGNITL E TD GLHR+LV
Sbjct: 726 VVFQVIAVDNDTGMNAEVRYSIVG--GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLV 783
Query: 823 KVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
K +D G P+ L S V+VNLFVN++V+N + I L+RK E
Sbjct: 784 KANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 823
>gi|14589942 protocadherin 11 Y-linked isoform a [Homo sapiens]
Length = 1037
Score = 623 bits (1606), Expect = e-178
Identities = 345/820 (42%), Positives = 503/820 (61%), Gaps = 43/820 (5%)
Query: 50 FLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRL--LPRSAGRPDPQSQLPE 107
++F C+ +S A E Y++ E +P VLIG+L +DL L +P + Q +L
Sbjct: 29 YIFAVLLVCVVFHSGAQEKNYTIREEIPENVLIGNLLKDLNLSLIPNKSLTTTMQFKLVY 88
Query: 108 RTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVS 167
+TG + PL + ++ +GE+ T+ IDRE LC
Sbjct: 89 KTG---DVPL-------------IRIEEDTGEIFTTGARIDREKLC-------------- 118
Query: 168 ISSSPSDS-CLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNT 226
+ P D C ++V +LP E FR VK++ I DINDNAP FP + I++ +PEN+ +N+
Sbjct: 119 -AGIPRDEHCFYEVEVAILPDEIFRLVKIRFLIEDINDNAPLFPATVINISIPENSAINS 177
Query: 227 RLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQY 286
+ + AVDPDVGINGVQ Y L+ +F LDV E G++ P LIV LDRE +D Y
Sbjct: 178 KYTLP-AAVDPDVGINGVQNYELIKSQNIFGLDVIETPEGDKMPQLIVQKELDREEKDTY 236
Query: 287 VSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVD 346
V + EDGG P +A L + ++D NDN P+F +++I V++ NA VGT + + A D
Sbjct: 237 VMKVKVEDGGFPQRSSTAILQVSVTDTNDNHPVFKETEIEVSIPENAPVGTSVTQLHATD 296
Query: 347 KDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCI 406
D+G NA+I +S+S V ++ LFHL+ TG+I + + +HKL +LA+ G +
Sbjct: 297 ADIGENAKIHFSFSNLVSNIARRLFHLNATTGLITIKEPLDREETPNHKLLVLASDGGLM 356
Query: 407 PAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKY--K 464
PA LV++ V P I RYI N ++ V L E P+NT IA T+ D + + +
Sbjct: 357 PARAMVLVNVTDVNDNVPSIDIRYIVNPVNDTVVLSENIPLNTKIALITVTDKDADHNGR 416
Query: 465 VNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIK 522
V C+ D E PFRL P ++N++LLE +DYE + Y + ++A ++ + ++
Sbjct: 417 VTCFTDHEIPFRLRPV--FSNQFLLENAAYLDYESTKEYAIKLLAADAGKPPLNQSAMLF 474
Query: 523 VQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYF 582
+++ D+NDNAP+F Q + ++I ENNSP L K+ ATDADS +++Y LGPDAP F
Sbjct: 475 IKVKDENDNAPVFTQSFVTVSIPENNSPGIQLMKVSATDADSGPNAEINYLLGPDAPPEF 534
Query: 583 SLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINK 642
SLD TG+LTV +LDRE+++KY +T+ A D G PP S TV ++++D+NDNSP F +
Sbjct: 535 SLDRRTGMLTVVKKLDREKEDKYLFTILAKDNGVPPLTSNVTVFVSIIDQNDNSPVFTHN 594
Query: 643 DFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDR 702
++ F+VPEN P +G +G+I+VTD D G N V LS+++++D F ID+ G++R +S DR
Sbjct: 595 EYKFYVPENLPRHGTVGLITVTDPDYGDNSAVTLSILDENDDFTIDSQTGVIRPNISFDR 654
Query: 703 EQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGS 762
E+Q SYT +V+A DGG + SS+AK+TI ++D+NDN P+ + P N SY LVLPST PG+
Sbjct: 655 EKQESYTFYVKAEDGGRVSRSSSAKVTINVVDVNDNKPVFIVPPYNYSYELVLPSTNPGT 714
Query: 763 PVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLV 822
V +V AVD DTGMNA + YSI+G G + F ID +TGNITL E TD GLHR+LV
Sbjct: 715 VVFQVIAVDNDTGMNAEVRYSIVG--GNTRDLFAIDQETGNITLMEKCDVTDLGLHRVLV 772
Query: 823 KVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
K +D G P+ L S V+VNLFVN++V+N + I L+RK E
Sbjct: 773 KANDLGQPDSLFSVVIVNLFVNESVTNATLINELVRKSIE 812
>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
Length = 1237
Score = 436 bits (1120), Expect = e-122
Identities = 300/854 (35%), Positives = 438/854 (51%), Gaps = 68/854 (7%)
Query: 24 PRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIG 83
PR++ R H P LP + L L + S AT ++Y + E P LIG
Sbjct: 21 PRMEHLR-HSPGPGGQRLLLPSMLLALLLL----LAPSPGHATRVVYKVPEEQPPNTLIG 75
Query: 84 SLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTS 143
SLA D G PD GA Y+ +D ++G++ T+
Sbjct: 76 SLAADY-------GFPDVGHLYKLEVGAP-----------------YLRVDGKTGDIFTT 111
Query: 144 AQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLV---LPQEYFRFVKVKIAIR 200
IDRE L + P D C+L +V + + R ++ +I ++
Sbjct: 112 ETSIDREGL------------RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQ 159
Query: 201 DINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLL---DYHGMFT 257
DINDN P F I++ +PEN + + I A D D G NGV +Y L + +F
Sbjct: 160 DINDNTPNFASPVITLAIPENTNIGSLFPIPL-ASDRDAGPNGVASYELQAGPEAQELFG 218
Query: 258 LDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNC 317
L V E++ E+ P LIVMG LDRE D Y I +DGGSPP SA L + + D NDN
Sbjct: 219 LQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNA 277
Query: 318 PLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENT 377
P F + N+ +G + V+A D D G NA+I Y++ Q P+ + L LD NT
Sbjct: 278 PKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVRRLLRLDRNT 336
Query: 378 GVIKLFSKIGGSVLESHKLTILANGPGCIPAVITA--LVSIIKVIFRPPEIVPRYIA--N 433
G+I + + L + + ++LA G P A +V++ + P I R I
Sbjct: 337 GLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVT 396
Query: 434 EIDGVVYLKELEPVNTPIAFFTI--RDPEGKYKVNCYLDGEGPFRLSPYKPYNNE----Y 487
DG+ + E T +A + RD V C + G+ PF+L ++ Y
Sbjct: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456
Query: 488 LLETTKPMDYELQQFYEVAVVAWNSEGFHVKRV--IKVQLLDDNDNAPIFLQPLIELTIE 545
L+TT P+DYE + Y + +VA +S + +KVQ++D NDNAP+F Q + E+
Sbjct: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFP 516
Query: 546 ENNSPNAFLTKLYATDADSEERGQVSYFLGPD--APSYFSLDSVTGILTVSTQLDREEKE 603
ENN P + ++ A+DADS ++ Y L P+ A F++ TG + V T LDRE++E
Sbjct: 517 ENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRE 576
Query: 604 KYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISV 663
Y V A D G P + ATV + VLD NDN P+F+ ++F V EN P +G+++V
Sbjct: 577 SYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTV 636
Query: 664 TDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALS 723
D D G N V LSV + FVI G G + + +S DREQQS+YT ++AVDGG P S
Sbjct: 637 IDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRS 696
Query: 724 STAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYS 783
+ +TI +LD NDN P + P SN S+ L+ P T G V++V A D D+G+NA + YS
Sbjct: 697 AYVGVTINVLDENDNAPYITAP-SNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS 755
Query: 784 IIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFV 843
I G G F+I +G ITLE+ + + +GLHRL+VKVSD G P P + T +V+L+V
Sbjct: 756 IAG--GNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP-PRYGTALVHLYV 812
Query: 844 NDTVSNESYIESLL 857
N+T++N + +E+LL
Sbjct: 813 NETLANRTLLETLL 826
>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
Length = 1060
Score = 436 bits (1120), Expect = e-122
Identities = 300/854 (35%), Positives = 438/854 (51%), Gaps = 68/854 (7%)
Query: 24 PRLDMGRLHRPRSSTSYRNLPHLFLFFLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIG 83
PR++ R H P LP + L L + S AT ++Y + E P LIG
Sbjct: 21 PRMEHLR-HSPGPGGQRLLLPSMLLALLLL----LAPSPGHATRVVYKVPEEQPPNTLIG 75
Query: 84 SLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTS 143
SLA D G PD GA Y+ +D ++G++ T+
Sbjct: 76 SLAADY-------GFPDVGHLYKLEVGAP-----------------YLRVDGKTGDIFTT 111
Query: 144 AQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLV---LPQEYFRFVKVKIAIR 200
IDRE L + P D C+L +V + + R ++ +I ++
Sbjct: 112 ETSIDREGL------------RECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQ 159
Query: 201 DINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLL---DYHGMFT 257
DINDN P F I++ +PEN + + I A D D G NGV +Y L + +F
Sbjct: 160 DINDNTPNFASPVITLAIPENTNIGSLFPIPL-ASDRDAGPNGVASYELQAGPEAQELFG 218
Query: 258 LDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNC 317
L V E++ E+ P LIVMG LDRE D Y I +DGGSPP SA L + + D NDN
Sbjct: 219 LQVAEDQE-EKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNA 277
Query: 318 PLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENT 377
P F + N+ +G + V+A D D G NA+I Y++ Q P+ + L LD NT
Sbjct: 278 PKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQ-APEVVRRLLRLDRNT 336
Query: 378 GVIKLFSKIGGSVLESHKLTILANGPGCIPAVITA--LVSIIKVIFRPPEIVPRYIA--N 433
G+I + + L + + ++LA G P A +V++ + P I R I
Sbjct: 337 GLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVT 396
Query: 434 EIDGVVYLKELEPVNTPIAFFTI--RDPEGKYKVNCYLDGEGPFRLSPYKPYNNE----Y 487
DG+ + E T +A + RD V C + G+ PF+L ++ Y
Sbjct: 397 HQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKY 456
Query: 488 LLETTKPMDYELQQFYEVAVVAWNSEGFHVKRV--IKVQLLDDNDNAPIFLQPLIELTIE 545
L+TT P+DYE + Y + +VA +S + +KVQ++D NDNAP+F Q + E+
Sbjct: 457 FLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFP 516
Query: 546 ENNSPNAFLTKLYATDADSEERGQVSYFLGPD--APSYFSLDSVTGILTVSTQLDREEKE 603
ENN P + ++ A+DADS ++ Y L P+ A F++ TG + V T LDRE++E
Sbjct: 517 ENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRE 576
Query: 604 KYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISV 663
Y V A D G P + ATV + VLD NDN P+F+ ++F V EN P +G+++V
Sbjct: 577 SYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTV 636
Query: 664 TDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALS 723
D D G N V LSV + FVI G G + + +S DREQQS+YT ++AVDGG P S
Sbjct: 637 IDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRS 696
Query: 724 STAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYS 783
+ +TI +LD NDN P + P SN S+ L+ P T G V++V A D D+G+NA + YS
Sbjct: 697 AYVGVTINVLDENDNAPYITAP-SNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYS 755
Query: 784 IIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFV 843
I G G F+I +G ITLE+ + + +GLHRL+VKVSD G P P + T +V+L+V
Sbjct: 756 IAG--GNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKP-PRYGTALVHLYV 812
Query: 844 NDTVSNESYIESLL 857
N+T++N + +E+LL
Sbjct: 813 NETLANRTLLETLL 826
>gi|14589933 protocadherin 7 isoform b precursor [Homo sapiens]
Length = 1072
Score = 405 bits (1041), Expect = e-113
Identities = 295/920 (32%), Positives = 451/920 (49%), Gaps = 112/920 (12%)
Query: 61 SYSRATELL-YSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSF 119
S + A +LL Y L E PA V IG++A DL ++ S ++F
Sbjct: 26 SLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSG-------------------EVTF 66
Query: 120 SLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLL 179
SL S +Y+ +DN +GEL TS + IDRE L + C L
Sbjct: 67 SLES---GSEYLKIDNLTGELSTSERRIDREKL------------PQCQMIFDENECFLD 111
Query: 180 LDVLVL--PQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNT----------- 226
+V V+ Q + + ++ + DINDN P FP +++ V EN PV T
Sbjct: 112 FEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRD 171
Query: 227 -------------------------RLAIEHPAVDPDVGINGVQ------TYRLLDYH-- 253
R A P G NG + R LD
Sbjct: 172 FGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEG 231
Query: 254 ----------GMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGS 303
+F L V + +GE+ P LIV GALDRE +D Y + DGG PP
Sbjct: 232 GGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQ 291
Query: 304 ATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKV 363
A L + I+D+NDN P F S + N+ GTPI ++A D D+G N QI Y +
Sbjct: 292 AILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAAT 351
Query: 364 PQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAV--ITALVSIIKVIF 421
++ + L LDE +G + + +I + + T++A G P T +++I
Sbjct: 352 -ESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDEND 410
Query: 422 RPPEIVPRYIANEI--DGVVYLKELEPVNTPIAFFTI--RDPEGKYKVNCYLDGEGPFRL 477
P I R I DGV + E V+TPIA + RD V C + G+ PF+L
Sbjct: 411 NVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQL 470
Query: 478 SPYKPYNNE-----YLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKVQLLDDND 530
P + Y L T+ P+DYE + + V +VA +S + V++ D ND
Sbjct: 471 KPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTND 530
Query: 531 NAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGI 590
N P+F Q ++E+ ENN P + + ATDADS + +++Y L F++D +G
Sbjct: 531 NPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGD 590
Query: 591 LTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPE 650
+ V+T LDRE+ ++Y + V A D G P + TV + V DKNDN P+F+ F+F+V E
Sbjct: 591 ILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKE 650
Query: 651 NFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTL 710
N +G+++V DAD GRN ++L + ++IF I+ G + + +S DRE Q++YT
Sbjct: 651 NLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTF 710
Query: 711 WVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAV 770
V+AVDGG+P S+TA +++ ++D NDN P V P+ N+SY L+ PS+ + V V A
Sbjct: 711 RVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPK-NISYTLLPPSSNVRTVVATVLAT 769
Query: 771 DKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYP 830
D D G+NA + YSI+G G + F IDP +G ++L L Q YGLHRL+V+V+D G P
Sbjct: 770 DSDDGINADLNYSIVG--GNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQP 827
Query: 831 EPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTL 890
+T +V++FVN++VSN + I+S + + I + + I+ +P++ + +
Sbjct: 828 SQ-STTTLVHVFVNESVSNATAIDSQIARSLHIPLTQ---DIAGDPSYEISKQRLSIVIG 883
Query: 891 VALSVISLGSITLVTGMGIY 910
V ++++ I L+ M Y
Sbjct: 884 VVAGIMTVILIILIVVMARY 903
>gi|14589931 protocadherin 7 isoform a precursor [Homo sapiens]
Length = 1069
Score = 405 bits (1041), Expect = e-113
Identities = 295/920 (32%), Positives = 451/920 (49%), Gaps = 112/920 (12%)
Query: 61 SYSRATELL-YSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSF 119
S + A +LL Y L E PA V IG++A DL ++ S ++F
Sbjct: 26 SLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSG-------------------EVTF 66
Query: 120 SLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLL 179
SL S +Y+ +DN +GEL TS + IDRE L + C L
Sbjct: 67 SLES---GSEYLKIDNLTGELSTSERRIDREKL------------PQCQMIFDENECFLD 111
Query: 180 LDVLVL--PQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNT----------- 226
+V V+ Q + + ++ + DINDN P FP +++ V EN PV T
Sbjct: 112 FEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGTLYLLPTATDRD 171
Query: 227 -------------------------RLAIEHPAVDPDVGINGVQ------TYRLLDYH-- 253
R A P G NG + R LD
Sbjct: 172 FGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASEG 231
Query: 254 ----------GMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGS 303
+F L V + +GE+ P LIV GALDRE +D Y + DGG PP
Sbjct: 232 GGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGALDREQRDSYELTLRVRDGGDPPRSSQ 291
Query: 304 ATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKV 363
A L + I+D+NDN P F S + N+ GTPI ++A D D+G N QI Y +
Sbjct: 292 AILRVLITDVNDNSPRFEKSVYEADLAENSAPGTPILQLRAADLDVGVNGQIEYVFGAAT 351
Query: 364 PQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAV--ITALVSIIKVIF 421
++ + L LDE +G + + +I + + T++A G P T +++I
Sbjct: 352 -ESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKTDKATVVLNIKDEND 410
Query: 422 RPPEIVPRYIANEI--DGVVYLKELEPVNTPIAFFTI--RDPEGKYKVNCYLDGEGPFRL 477
P I R I DGV + E V+TPIA + RD V C + G+ PF+L
Sbjct: 411 NVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENGVVTCTVVGDVPFQL 470
Query: 478 SPYKPYNNE-----YLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKVQLLDDND 530
P + Y L T+ P+DYE + + V +VA +S + V++ D ND
Sbjct: 471 KPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLSSNNSLIVKVGDTND 530
Query: 531 NAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGI 590
N P+F Q ++E+ ENN P + + ATDADS + +++Y L F++D +G
Sbjct: 531 NPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDSSVMGIFAIDPDSGD 590
Query: 591 LTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPE 650
+ V+T LDRE+ ++Y + V A D G P + TV + V DKNDN P+F+ F+F+V E
Sbjct: 591 ILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDNDPKFMQDVFTFYVKE 650
Query: 651 NFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTL 710
N +G+++V DAD GRN ++L + ++IF I+ G + + +S DRE Q++YT
Sbjct: 651 NLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYSTMSFDREHQTTYTF 710
Query: 711 WVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAV 770
V+AVDGG+P S+TA +++ ++D NDN P V P+ N+SY L+ PS+ + V V A
Sbjct: 711 RVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPK-NISYTLLPPSSNVRTVVATVLAT 769
Query: 771 DKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYP 830
D D G+NA + YSI+G G + F IDP +G ++L L Q YGLHRL+V+V+D G P
Sbjct: 770 DSDDGINADLNYSIVG--GNPFKLFEIDPTSGVVSLVGKLTQKHYGLHRLVVQVNDSGQP 827
Query: 831 EPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTL 890
+T +V++FVN++VSN + I+S + + I + + I+ +P++ + +
Sbjct: 828 SQ-STTTLVHVFVNESVSNATAIDSQIARSLHIPLTQ---DIAGDPSYEISKQRLSIVIG 883
Query: 891 VALSVISLGSITLVTGMGIY 910
V ++++ I L+ M Y
Sbjct: 884 VVAGIMTVILIILIVVMARY 903
>gi|14589935 protocadherin 7 isoform c precursor [Homo sapiens]
Length = 1200
Score = 369 bits (948), Expect = e-102
Identities = 279/874 (31%), Positives = 436/874 (49%), Gaps = 67/874 (7%)
Query: 61 SYSRATELL-YSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSF 119
S + A +LL Y L E PA V IG++A DL ++ S ++F
Sbjct: 26 SLAAAKQLLRYRLAEEGPADVRIGNVASDLGIVTGSG-------------------EVTF 66
Query: 120 SLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLL 179
SL S +Y+ +DN +GEL TS + IDRE L + C L
Sbjct: 67 SLES---GSEYLKIDNLTGELSTSERRIDREKL------------PQCQMIFDENECFLD 111
Query: 180 LDVLVL--PQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDP 237
+V V+ Q + + ++ + DINDN P FP +++ V EN PV T L + A D
Sbjct: 112 FEVSVIGPSQSWVDLFEGQVIVLDINDNTPTFPSPVLTLTVEENRPVGT-LYLLPTATDR 170
Query: 238 DVGINGVQTYRLLDYHGMFTLDVEENENG--ERTPYLIV--MGALDRETQDQYVSIIIAE 293
D G NG++ Y LL G E G + PY GA + + +E
Sbjct: 171 DFGRNGIERYELLQEPGGGGSGGESRRAGAADSAPYPGGGGNGASGGGSGGSKRRLDASE 230
Query: 294 DGGSPPLLG-SATLTIGISDINDN---CPLFTDSQINVTVYGNATVGTPIAAVQAVDKDL 349
GG G S+ + ++D D L + N+ GTPI ++A D D+
Sbjct: 231 GGGGTNPGGRSSVFELQVADTPDGEKQPQLIVKGVYEADLAENSAPGTPILQLRAADLDV 290
Query: 350 GTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAV 409
G N QI Y + ++ + L LDE +G + + +I + + T++A G P
Sbjct: 291 GVNGQIEYVFGAAT-ESVRRLLRLDETSGWLSVLHRIDREEVNQLRFTVMARDRGQPPKT 349
Query: 410 --ITALVSIIKVIFRPPEIVPRYIANEI--DGVVYLKELEPVNTPIAFFTI--RDPEGKY 463
T +++I P I R I DGV + E V+TPIA + RD
Sbjct: 350 DKATVVLNIKDENDNVPSIEIRKIGRIPLKDGVANVAEDVLVDTPIALVQVSDRDQGENG 409
Query: 464 KVNCYLDGEGPFRLSPYKPYNNE-----YLLETTKPMDYELQQFYEVAVVAWNS--EGFH 516
V C + G+ PF+L P + Y L T+ P+DYE + + V +VA +S
Sbjct: 410 VVTCTVVGDVPFQLKPASDTEGDQNKKKYFLHTSTPLDYEATREFNVVIVAVDSGSPSLS 469
Query: 517 VKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGP 576
+ V++ D NDN P+F Q ++E+ ENN P + + ATDADS + +++Y L
Sbjct: 470 SNNSLIVKVGDTNDNPPMFGQSVVEVYFPENNIPGERVATVLATDADSGKNAEIAYSLDS 529
Query: 577 DAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNS 636
F++D +G + V+T LDRE+ ++Y + V A D G P + TV + V DKNDN
Sbjct: 530 SVMGIFAIDPDSGDILVNTVLDREQTDRYEFKVNAKDKGIPVLQGSTTVIVQVADKNDND 589
Query: 637 PRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKGMLRA 696
P+F+ F+F+V EN +G+++V DAD GRN ++L + ++IF I+ G + +
Sbjct: 590 PKFMQDVFTFYVKENLQPNSPVGMVTVMDADKGRNAEMSLYIEENNNIFSIENDTGTIYS 649
Query: 697 KVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLP 756
+S DRE Q++YT V+AVDGG+P S+TA +++ ++D NDN P V P+ N+SY L+ P
Sbjct: 650 TMSFDREHQTTYTFRVKAVDGGDPPRSATATVSLFVMDENDNAPTVTLPK-NISYTLLPP 708
Query: 757 STLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYG 816
S+ + V V A D D G+NA + YSI+G G + F IDP +G ++L L Q YG
Sbjct: 709 SSNVRTVVATVLATDSDDGINADLNYSIVG--GNPFKLFEIDPTSGVVSLVGKLTQKHYG 766
Query: 817 LHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEP 876
LHRL+V+V+D G P +T +V++FVN++VSN + I+S + + I + + I+ +P
Sbjct: 767 LHRLVVQVNDSGQPSQ-STTTLVHVFVNESVSNATAIDSQIARSLHIPLTQ---DIAGDP 822
Query: 877 THRKVESVSCMPTLVALSVISLGSITLVTGMGIY 910
++ + + V ++++ I L+ M Y
Sbjct: 823 SYEISKQRLSIVIGVVAGIMTVILIILIVVMARY 856
>gi|14589929 protocadherin 18 precursor [Homo sapiens]
Length = 1135
Score = 287 bits (735), Expect = 3e-77
Identities = 216/711 (30%), Positives = 338/711 (47%), Gaps = 67/711 (9%)
Query: 47 FLFFLFVGPFS--CLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQ 104
F+F L + F+ LG L Y + E G +I L+ED+ D +
Sbjct: 12 FVFALLIVSFNHDVLGK-----NLKYRIYEEQRVGSVIARLSEDVA---------DVLLK 57
Query: 105 LPERTGAEWNPP-LSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWS 163
LP NP + F RG S V ++ +GE+ A IDRE LC +
Sbjct: 58 LP-------NPSTVRFRAMQRGNSPLLVVNED-NGEISIGAT-IDREQLCQK-------- 100
Query: 164 GSVSISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAP 223
+ +C + DV+ LP E+ + +++ + DINDN+PQF S I + + E+A
Sbjct: 101 ---------NLNCSIEFDVITLPTEHLQLFHIEVEVLDINDNSPQFSRSLIPIEISESAA 151
Query: 224 VNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQ 283
V TR+ ++ A DPDVG N + TY L + F ++V +G + LIV+ LDRE +
Sbjct: 152 VGTRIPLDS-AFDPDVGENSLHTYSL-SANDFFNIEVRTRTDGAKYAELIVVRELDRELK 209
Query: 284 DQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQ 343
Y + A D G P GS+ L I ISD NDN P F + + N+ VGT + +
Sbjct: 210 SSYELQLTASDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLLENSPVGTLLLDLN 269
Query: 344 AVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILAN-- 401
A D D G N +I YS+S V + F +D G + LF ++ + +S+++ + A
Sbjct: 270 ATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDL 329
Query: 402 GPGCIPAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEG 461
GP IPA ++ ++ V PEI ++ + + Y+ E +P++T +A ++D +
Sbjct: 330 GPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDS 389
Query: 462 --KYKVNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWN--SEGFHV 517
++ C L G G F+L K Y N YL+ T +D E + Y + V+A + +
Sbjct: 390 GLNGEIVCKLHGHGHFKLQ--KTYENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLST 447
Query: 518 KRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSY----- 572
+ VQ+ D NDN P F + E I ENNSP A++T + ATD D E GQV+Y
Sbjct: 448 VKHFTVQINDINDNPPHFQRSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILES 507
Query: 573 -FLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPR-ESVATVALTVL 630
LG +Y ++D G + D EE + + V A D G P + S TV LT++
Sbjct: 508 FILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTII 567
Query: 631 DKNDNSPRFI-----NKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVV--NQSD 683
D+NDN P I N +P+ + I D D+G N ++ ++V N+ +
Sbjct: 568 DENDNVPVVIGPALRNNTAEITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVAGNEEN 627
Query: 684 IFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLD 734
IF+ID + VS+D + + L V D G P L + + ++ +
Sbjct: 628 IFIIDPRSCDIHTNVSMDSVPYTEWELSVIIQDKGNPQLHTKVLLKCMIFE 678
Score = 171 bits (433), Expect = 3e-42
Identities = 160/573 (27%), Positives = 263/573 (45%), Gaps = 54/573 (9%)
Query: 306 LTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQ 365
+ + + DINDN P F+ S I + + +A VGT I A D D+G N+ TYS S
Sbjct: 123 IEVEVLDINDNSPQFSRSLIPIEISESAAVGTRIPLDSAFDPDVGENSLHTYSLS----- 177
Query: 366 ASKDLFHLDENTGV-------IKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIK 418
+ D F+++ T + + ++ + S++L + A+ G +P + SI+K
Sbjct: 178 -ANDFFNIEVRTRTDGAKYAELIVVRELDRELKSSYELQLTASDMG-VPQRSGS--SILK 233
Query: 419 V-IFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPE----GKYKVNCYLDGEG 473
+ I + P + + ++ L E PV T + DP+ GK V +
Sbjct: 234 ISISDSNDNSPAF--EQQSYIIQLLENSPVGTLLLDLNATDPDEGANGKI-VYSFSSHVS 290
Query: 474 PFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAW----NSEGFHVKRVIKVQLLDDN 529
P + +K + L K +DYE+ + YE+ V A NS H K +IKV +D N
Sbjct: 291 PKIMETFKIDSERGHLTLFKQVDYEITKSYEIDVQAQDLGPNSIPAHCKIIIKV--VDVN 348
Query: 530 DNAPIFLQPLI-----ELT-IEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFS 583
DN P L+ E++ I E + + F+ + D DS G++ L +F
Sbjct: 349 DNKPEININLMSPGKEEISYIFEGDPIDTFVALVRVQDKDSGLNGEIVCKL--HGHGHFK 406
Query: 584 LDSV---TGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFI 640
L ++ + LDRE++ +Y TV A D G P +V + + D NDN P F
Sbjct: 407 LQKTYENNYLILTNATLDREKRSEYSLTVIAEDRGTPSLSTVKHFTVQINDINDNPPHFQ 466
Query: 641 NKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQ-------SDIFVIDTGKGM 693
+ F + EN I ++ TD D G NG V +++ + ID G
Sbjct: 467 RSRYEFVISENNSPGAYITTVTATDPDLGENGQVTYTILESFILGSSITTYVTIDPSNGA 526
Query: 694 LRAKVSLDREQQSSYTLWVEAVDGGEPA-LSSTAKITILLLDINDNPPLVLFP--QSNMS 750
+ A D E+ S T VEA DGG P L S + + ++D NDN P+V+ P ++N +
Sbjct: 527 IYALRIFDHEEVSQITFVVEARDGGSPKQLVSNTTVVLTIIDENDNVPVVIGPALRNNTA 586
Query: 751 YLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEAL 810
+ + G VT + A+D+D+G+NA ++ +I+ G F IDP++ +I ++
Sbjct: 587 EITIPKGAESGFHVTRIRAIDRDSGVNAELSCAIVA--GNEENIFIIDPRSCDIHTNVSM 644
Query: 811 LQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFV 843
Y L V + D G P+ LH+ V++ +
Sbjct: 645 DSVPYTEWELSVIIQDKGNPQ-LHTKVLLKCMI 676
Score = 136 bits (342), Expect = 1e-31
Identities = 112/386 (29%), Positives = 175/386 (45%), Gaps = 36/386 (9%)
Query: 489 LETTKPMDYELQQFYEVAVVAWNSEGFHVKR---VIKVQLLDDNDNAPIFLQPLIELTIE 545
L + +D EL+ YE+ + A + G + ++K+ + D NDN+P F Q + +
Sbjct: 198 LIVVRELDRELKSSYELQLTA-SDMGVPQRSGSSILKISISDSNDNSPAFEQQSYIIQLL 256
Query: 546 ENNSPNAFLTKLYATDADSEERGQVSY----FLGPDAPSYFSLDSVTGILTVSTQLDREE 601
EN+ L L ATD D G++ Y + P F +DS G LT+ Q+D E
Sbjct: 257 ENSPVGTLLLDLNATDPDEGANGKIVYSFSSHVSPKIMETFKIDSERGHLTLFKQVDYEI 316
Query: 602 KEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRF-IN-----KDFSFFVPENFPGY 655
+ Y V+A D G + + + V+D NDN P IN K+ ++ E P
Sbjct: 317 TKSYEIDVQAQDLGPNSIPAHCKIIIKVVDVNDNKPEININLMSPGKEEISYIFEGDPID 376
Query: 656 GEIGVISVTDADAGRNGWVALSVVNQSDIFVIDTGKG--MLRAKVSLDREQQSSYTLWVE 713
+ ++ V D D+G NG + + + T + ++ +LDRE++S Y+L V
Sbjct: 377 TFVALVRVQDKDSGLNGEIVCKLHGHGHFKLQKTYENNYLILTNATLDREKRSEYSLTVI 436
Query: 714 AVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVLPSTLPGSPVTEVYAVDKD 773
A D G P+LS+ T+ + DINDNPP F +S + ++ + PG+ +T V A D D
Sbjct: 437 AEDRGTPSLSTVKHFTVQINDINDNPP--HFQRSRYEF-VISENNSPGAYITTVTATDPD 493
Query: 774 TGMNAVIAYSIIGRRGPRPESF----------RIDPKTGNITLEEALLQTDYGLHRLLVK 823
G N + Y+I+ ESF IDP G I + +V+
Sbjct: 494 LGENGQVTYTIL-------ESFILGSSITTYVTIDPSNGAIYALRIFDHEEVSQITFVVE 546
Query: 824 VSDHGYPEPLHSTVMVNLFVNDTVSN 849
D G P+ L S V L + D N
Sbjct: 547 ARDGGSPKQLVSNTTVVLTIIDENDN 572
>gi|14195607 protocadherin beta 1 precursor [Homo sapiens]
Length = 818
Score = 280 bits (717), Expect = 3e-75
Identities = 222/723 (30%), Positives = 349/723 (48%), Gaps = 74/723 (10%)
Query: 56 FSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRL-LPRSAGRPDPQSQLPERTGAEWN 114
F C+ S AT + YS+ E + +G + ++A+DL L + + A R GA
Sbjct: 20 FLCI-SVGDATTIRYSVAEEMESGSFVANVAKDLGLEVGKLAAR-----------GAR-- 65
Query: 115 PPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSD 174
L S G + + L ++G+L +++DRE+LC +D
Sbjct: 66 ------LVSEG-NKMHFRLHRKTGDLFVK-EKLDRESLC-----------------GKAD 100
Query: 175 SCLLLLDV-LVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHP 233
C+L +V LV P + FR ++ + DINDNAP F + + +PE+ P+ +R ++
Sbjct: 101 PCVLHFEVVLVEPLQSFR---AEVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQS- 156
Query: 234 AVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAE 293
A D DVG+NG+Q Y L +G F L +G + L++ LDRE Q + I A
Sbjct: 157 AQDLDVGLNGLQNYTL-SANGYFHLHTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAV 215
Query: 294 DGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNA 353
DGGSPP G+A + + + D+ND+ P F+ V N+ G+ +A V AVD D GTN
Sbjct: 216 DGGSPPKSGTAHIHVVVLDVNDHVPQFSRLVYRAQVSENSPNGSLVATVTAVDLDEGTNK 275
Query: 354 QITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITAL 413
ITYS +Q P+A F +D G ++L + +E++ + I A G + A L
Sbjct: 276 AITYSLAQN-PEAILKTFQIDPQNGEVRLRGPLDFEAIETYDIDIQATDGGGLSAHSKVL 334
Query: 414 VSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKY--KVNCYLDG 471
V ++ V PPE++ +++ L E P T +A FTIRD + + KV C+L
Sbjct: 335 VEVVDVNDNPPEVMVSSVSSP------LPEDSPPQTVVALFTIRDRDIRVGGKVTCFLRE 388
Query: 472 EGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKVQLLDDN 529
+ PF + P + N Y L T + +D E Y + +VA ++ + +I+V + D N
Sbjct: 389 DLPFVIKP--TFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVN 446
Query: 530 DNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGP------DAPSYFS 583
DN PIF + LT+ ENNSP F+ K++A D D E Q++Y L P +Y S
Sbjct: 447 DNPPIFREDSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYIS 506
Query: 584 LDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKD 643
++S G L +D E + +++ V+A D G S TV + VLD NDN P +
Sbjct: 507 INSGNGKLYALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPL 566
Query: 644 FSFFVPEN--FPGYGEIGV----ISVTDADAGRNGWVALSVVNQSD--IFVIDTGKGMLR 695
+ +P N P E G + D D+G+N W++ ++ +D +F + G +
Sbjct: 567 QNGTLPCNDLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLLKATDLGLFSVQRQNGEIH 626
Query: 696 AKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLLVL 755
+ L + D G+PALS+T + ILL+D + P + F V
Sbjct: 627 TLRQISERDPMMQKLIILVQDHGQPALSTTVSLNILLVD-GFSEPYLQFQDPTKHSRKVN 685
Query: 756 PST 758
PST
Sbjct: 686 PST 688
Score = 171 bits (434), Expect = 2e-42
Identities = 161/583 (27%), Positives = 256/583 (43%), Gaps = 52/583 (8%)
Query: 301 LGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYS 360
L S + + DINDN P+F + + + + + +G+ A D D+G N Y+ S
Sbjct: 114 LQSFRAEVRVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLS 173
Query: 361 QKVPQASKDLFHLDENTGVIKLFSKIGGSVLESH---------KLTILANGPGCIPAVIT 411
+ FHL +T K VL LTI A G P T
Sbjct: 174 ------ANGYFHL--HTRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGT 225
Query: 412 ALVSIIKVIFRPPEIVPRYIANEIDGVVY---LKELEPVNTPIAFFTIRD-PEGKYKVNC 467
A + + V+ + VP++ +VY + E P + +A T D EG K
Sbjct: 226 AHIHV--VVLDVNDHVPQF-----SRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAIT 278
Query: 468 YLDGEGP---FRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQ 524
Y + P + P N E L P+D+E + Y++ + A + G + V+
Sbjct: 279 YSLAQNPEAILKTFQIDPQNGEVRLRG--PLDFEAIETYDIDIQATDGGGLSAHSKVLVE 336
Query: 525 LLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSL 584
++D NDN P + + + E++ P + D D G+V+ FL D P F +
Sbjct: 337 VVDVNDNPPEVMVSSVSSPLPEDSPPQTVVALFTIRDRDIRVGGKVTCFLREDLP--FVI 394
Query: 585 DSVTG---ILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFIN 641
G L LDREE Y T+ A+D G P + + + + D NDN P F
Sbjct: 395 KPTFGNSYSLVTDRSLDREEVSGYNITIVAMDTGPPSLSAETMIEVLISDVNDNPPIFRE 454
Query: 642 KDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVV--NQSDIFV-----IDTGKGML 694
+ V EN IG + D D G N + S++ D+ V I++G G L
Sbjct: 455 DSYILTVRENNSPAVFIGKVHAEDLDLGENAQITYSLLPPKNGDLSVFAYISINSGNGKL 514
Query: 695 RAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYL-- 752
A ++D E + V+A DGG +LSS + +++LD NDN P++L+P N +
Sbjct: 515 YALRTMDYEAIQDFQFVVKATDGGFLSLSSQVTVRVVVLDDNDNRPMILYPLQNGTLPCN 574
Query: 753 -LVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALL 811
LV S G VT+V AVD D+G N+ ++Y ++ + F + + G I +
Sbjct: 575 DLVPRSAEAGYLVTKVVAVDGDSGQNSWLSYHLL--KATDLGLFSVQRQNGEIHTLRQIS 632
Query: 812 QTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIE 854
+ D + +L++ V DHG P L +TV +N+ + D S E Y++
Sbjct: 633 ERDPMMQKLIILVQDHGQP-ALSTTVSLNILLVDGFS-EPYLQ 673
Score = 95.1 bits (235), Expect = 3e-19
Identities = 90/286 (31%), Positives = 125/286 (43%), Gaps = 38/286 (13%)
Query: 581 YFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKP-------------PRESVATVAL 627
+F L TG L V +LDRE CGK P +S +
Sbjct: 74 HFRLHRKTGDLFVKEKLDRESL-----------CGKADPCVLHFEVVLVEPLQSFRA-EV 121
Query: 628 TVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGW--VALSVVNQSDIF 685
V D NDN+P F+NK+ +PE+ P + S D D G NG LS +
Sbjct: 122 RVFDINDNAPVFLNKEPLLKIPESTPLGSRFPLQSAQDLDVGLNGLQNYTLSANGYFHLH 181
Query: 686 VIDTGKGMLRAKV----SLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPL 741
G A++ LDRE+Q L + AVDGG P S TA I +++LD+ND+ P
Sbjct: 182 TRFCSHGPKYAELVLNKPLDREEQPEVNLTITAVDGGSPPKSGTAHIHVVVLDVNDHVPQ 241
Query: 742 VLFPQSNMSYLLVLPSTLP-GSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPK 800
S + Y + P GS V V AVD D G N I YS+ ++F+IDP+
Sbjct: 242 F----SRLVYRAQVSENSPNGSLVATVTAVDLDEGTNKAITYSLAQNPEAILKTFQIDPQ 297
Query: 801 TGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLF-VND 845
G + L L + + ++ +D G HS V+V + VND
Sbjct: 298 NGEVRLRGPLDFEAIETYDIDIQATDGG-GLSAHSKVLVEVVDVND 342
>gi|14196451 protocadherin gamma subfamily A, 11 isoform 2 precursor
[Homo sapiens]
Length = 837
Score = 280 bits (715), Expect = 6e-75
Identities = 212/710 (29%), Positives = 348/710 (49%), Gaps = 77/710 (10%)
Query: 46 LFLFFLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQL 105
L L +F+G RA ++ YS+ E G +G++++DL L PR +L
Sbjct: 14 LLLLCIFLGTLRGF----RARQIRYSVPEETEKGSFVGNISKDLGLEPR---------EL 60
Query: 106 PERTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGS 165
+R + SRG + Q ++ RSG L T+ + IDRE LC
Sbjct: 61 AKR---------GVRIVSRGKT-QLFAVNPRSGSLITAGR-IDREELC------------ 97
Query: 166 VSISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVN 225
SC L +++LV ++ + V++ I DINDNAP F ++ + V E+A
Sbjct: 98 -----ETVSSCFLNMELLV--EDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPG 150
Query: 226 TRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQ 285
R A+ + A DPDVG+N +Q+Y+L + F+L + +G + P L++ G+LDRE +
Sbjct: 151 ARFALPN-ARDPDVGVNSLQSYQLSP-NNYFSLQLRGRTDGAKNPELVLEGSLDREKEAA 208
Query: 286 YVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAV 345
++ ++ A DGG P G+ + + + D+ND+ P+FT S V+V N + GT + V A
Sbjct: 209 HLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNAT 268
Query: 346 DKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGC 405
D D G N ++ YS+ +AS ++F LD TG +++ + +++ I G
Sbjct: 269 DPDEGINGEVMYSFRNMESKAS-EIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG 327
Query: 406 IPAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEG--KY 463
+ T L++++ V PEI I + I+ ++ E P T IA ++D +
Sbjct: 328 LFTTTTMLITVVDVNDNAPEIT---ITSSINSIL---ENSPPGTVIALLNVQDQDSGENG 381
Query: 464 KVNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWN--SEGFHVKRVI 521
+V+C++ PF+L K Y N Y L T++ +D EL Q Y + + A + S + +
Sbjct: 382 QVSCFIPNHLPFKLE--KTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHV 439
Query: 522 KVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDA--- 578
+ + DDNDN P+F I ENN A + + A D DS++ V+Y L D
Sbjct: 440 WLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQG 499
Query: 579 ---PSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDN 635
SY S++S TG+L D E+ V A D G PP S +++L VLD+NDN
Sbjct: 500 VPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDN 559
Query: 636 SPRFI--------NKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSD--IF 685
+P + + PGY V++V D D+G+N W++ ++ S+ +F
Sbjct: 560 APEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAV-DKDSGQNAWLSYRLLKASEPGLF 618
Query: 686 VIDTGKGMLR-AKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLD 734
+ G +R A+ LDR+ +L V D G+P LS+T +T+ + D
Sbjct: 619 AVGEHTGEVRTARALLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 667
Score = 200 bits (508), Expect = 6e-51
Identities = 185/627 (29%), Positives = 274/627 (43%), Gaps = 55/627 (8%)
Query: 268 RTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTI-----GISDINDNCPLFTD 322
R+ LI G +DRE + VS + LL TL I I DINDN P F +
Sbjct: 81 RSGSLITAGRIDREELCETVSSCFL----NMELLVEDTLKIYGVEVEIIDINDNAPSFQE 136
Query: 323 SQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKL 382
++ + V +A G A A D D+G N+ +Y S P L G
Sbjct: 137 DEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLS---PNNYFSLQLRGRTDGAKNP 193
Query: 383 FSKIGGSV---LESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIANEIDGVV 439
+ GS+ E+ L +L G P + V I V+ + +P + + V
Sbjct: 194 ELVLEGSLDREKEAAHLLLLTALDGGDP-IRKGAVPIRVVVLDVNDHIPMFTQSVYR--V 250
Query: 440 YLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYL--------LET 491
+ E T + DP+ ++GE + + +E ++
Sbjct: 251 SVPENISSGTRVLMVNATDPDEG------INGEVMYSFRNMESKASEIFQLDSQTGEVQV 304
Query: 492 TKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPN 551
+D+E +FYE+ + + G + + ++D NDNAP +I EN+ P
Sbjct: 305 RGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPG 364
Query: 552 AFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGI---LTVSTQLDREEKEKYRYT 608
+ L D DS E GQVS F+ P F L+ G L S LDRE + Y T
Sbjct: 365 TVIALLNVQDQDSGENGQVSCFIPNHLP--FKLEKTYGNYYKLITSRVLDRELVQSYNIT 422
Query: 609 VRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADA 668
+ A D G PP + V L V D NDN P F + +S ++PEN P I ++ D D+
Sbjct: 423 LTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDS 482
Query: 669 GRNGWVALSVVNQ-------SDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA 721
+N V S+ + S I++ G+L A S D EQ L V A D G+P
Sbjct: 483 KQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPP 542
Query: 722 LSSTAKITILLLDINDNPPLVLFP----QSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMN 777
LSS +++ +LD NDN P +L+P + L S PG VT+V AVDKD+G N
Sbjct: 543 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQN 602
Query: 778 AVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTV 837
A ++Y ++ + P F + TG + ALL D L+V V DHG P PL +TV
Sbjct: 603 AWLSYRLL--KASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQP-PLSATV 659
Query: 838 MVNLFVNDTV----SNESYIESLLRKE 860
+ + V D++ ++ +ESL E
Sbjct: 660 TLTVAVADSIPEVLADLGSLESLANSE 686
Score = 85.5 bits (210), Expect = 2e-16
Identities = 75/295 (25%), Positives = 137/295 (46%), Gaps = 23/295 (7%)
Query: 582 FSLDSVTGILTVSTQLDREEK-EKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFI 640
F+++ +G L + ++DREE E ++ + V + ++D NDN+P F
Sbjct: 76 FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQ 135
Query: 641 NKDFSFFVPEN-FPGYG---------EIGVISVTDADAGRNGWVALSVVNQSDIFVIDTG 690
+ V E+ PG ++GV S+ N + +L + ++D
Sbjct: 136 EDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTD----GAK 191
Query: 691 KGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMS 750
L + SLDRE+++++ L + A+DGG+P I +++LD+ND+ P +F QS
Sbjct: 192 NPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIP--MFTQS--V 247
Query: 751 YLLVLPSTL-PGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEA 809
Y + +P + G+ V V A D D G+N + YS E F++D +TG + + +
Sbjct: 248 YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGS 307
Query: 810 LLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDT---VSNESYIESLLRKEP 861
L Y + + ++ D G + ++ + VND ++ S I S+L P
Sbjct: 308 LDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSP 362
>gi|11128039 protocadherin gamma subfamily A, 11 isoform 1 precursor
[Homo sapiens]
Length = 935
Score = 280 bits (715), Expect = 6e-75
Identities = 212/710 (29%), Positives = 348/710 (49%), Gaps = 77/710 (10%)
Query: 46 LFLFFLFVGPFSCLGSYSRATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQL 105
L L +F+G RA ++ YS+ E G +G++++DL L PR +L
Sbjct: 14 LLLLCIFLGTLRGF----RARQIRYSVPEETEKGSFVGNISKDLGLEPR---------EL 60
Query: 106 PERTGAEWNPPLSFSLASRGLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGS 165
+R + SRG + Q ++ RSG L T+ + IDRE LC
Sbjct: 61 AKR---------GVRIVSRGKT-QLFAVNPRSGSLITAGR-IDREELC------------ 97
Query: 166 VSISSSPSDSCLLLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVN 225
SC L +++LV ++ + V++ I DINDNAP F ++ + V E+A
Sbjct: 98 -----ETVSSCFLNMELLV--EDTLKIYGVEVEIIDINDNAPSFQEDEVEIKVSEHAIPG 150
Query: 226 TRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQ 285
R A+ + A DPDVG+N +Q+Y+L + F+L + +G + P L++ G+LDRE +
Sbjct: 151 ARFALPN-ARDPDVGVNSLQSYQLSP-NNYFSLQLRGRTDGAKNPELVLEGSLDREKEAA 208
Query: 286 YVSIIIAEDGGSPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAV 345
++ ++ A DGG P G+ + + + D+ND+ P+FT S V+V N + GT + V A
Sbjct: 209 HLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIPMFTQSVYRVSVPENISSGTRVLMVNAT 268
Query: 346 DKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGC 405
D D G N ++ YS+ +AS ++F LD TG +++ + +++ I G
Sbjct: 269 DPDEGINGEVMYSFRNMESKAS-EIFQLDSQTGEVQVRGSLDFEKYRFYEMEIQGQDGGG 327
Query: 406 IPAVITALVSIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEG--KY 463
+ T L++++ V PEI I + I+ ++ E P T IA ++D +
Sbjct: 328 LFTTTTMLITVVDVNDNAPEIT---ITSSINSIL---ENSPPGTVIALLNVQDQDSGENG 381
Query: 464 KVNCYLDGEGPFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAWN--SEGFHVKRVI 521
+V+C++ PF+L K Y N Y L T++ +D EL Q Y + + A + S + +
Sbjct: 382 QVSCFIPNHLPFKLE--KTYGNYYKLITSRVLDRELVQSYNITLTATDQGSPPLSAETHV 439
Query: 522 KVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDA--- 578
+ + DDNDN P+F I ENN A + + A D DS++ V+Y L D
Sbjct: 440 WLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDSKQNALVTYSLTDDTVQG 499
Query: 579 ---PSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDN 635
SY S++S TG+L D E+ V A D G PP S +++L VLD+NDN
Sbjct: 500 VPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPPLSSNVSLSLFVLDQNDN 559
Query: 636 SPRFI--------NKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSD--IF 685
+P + + PGY V++V D D+G+N W++ ++ S+ +F
Sbjct: 560 APEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAV-DKDSGQNAWLSYRLLKASEPGLF 618
Query: 686 VIDTGKGMLR-AKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLD 734
+ G +R A+ LDR+ +L V D G+P LS+T +T+ + D
Sbjct: 619 AVGEHTGEVRTARALLDRDALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 667
Score = 200 bits (508), Expect = 6e-51
Identities = 185/627 (29%), Positives = 274/627 (43%), Gaps = 55/627 (8%)
Query: 268 RTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTI-----GISDINDNCPLFTD 322
R+ LI G +DRE + VS + LL TL I I DINDN P F +
Sbjct: 81 RSGSLITAGRIDREELCETVSSCFL----NMELLVEDTLKIYGVEVEIIDINDNAPSFQE 136
Query: 323 SQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVIKL 382
++ + V +A G A A D D+G N+ +Y S P L G
Sbjct: 137 DEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLS---PNNYFSLQLRGRTDGAKNP 193
Query: 383 FSKIGGSV---LESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPRYIANEIDGVV 439
+ GS+ E+ L +L G P + V I V+ + +P + + V
Sbjct: 194 ELVLEGSLDREKEAAHLLLLTALDGGDP-IRKGAVPIRVVVLDVNDHIPMFTQSVYR--V 250
Query: 440 YLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSPYKPYNNEYL--------LET 491
+ E T + DP+ ++GE + + +E ++
Sbjct: 251 SVPENISSGTRVLMVNATDPDEG------INGEVMYSFRNMESKASEIFQLDSQTGEVQV 304
Query: 492 TKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPN 551
+D+E +FYE+ + + G + + ++D NDNAP +I EN+ P
Sbjct: 305 RGSLDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSPPG 364
Query: 552 AFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTGI---LTVSTQLDREEKEKYRYT 608
+ L D DS E GQVS F+ P F L+ G L S LDRE + Y T
Sbjct: 365 TVIALLNVQDQDSGENGQVSCFIPNHLP--FKLEKTYGNYYKLITSRVLDRELVQSYNIT 422
Query: 609 VRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADA 668
+ A D G PP + V L V D NDN P F + +S ++PEN P I ++ D D+
Sbjct: 423 LTATDQGSPPLSAETHVWLNVADDNDNPPVFPHSSYSAYIPENNPRGASIFSVTALDPDS 482
Query: 669 GRNGWVALSVVNQ-------SDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA 721
+N V S+ + S I++ G+L A S D EQ L V A D G+P
Sbjct: 483 KQNALVTYSLTDDTVQGVPLSSYVSINSNTGVLYALQSFDYEQFRDLELRVIARDSGDPP 542
Query: 722 LSSTAKITILLLDINDNPPLVLFP----QSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMN 777
LSS +++ +LD NDN P +L+P + L S PG VT+V AVDKD+G N
Sbjct: 543 LSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVTKVVAVDKDSGQN 602
Query: 778 AVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTV 837
A ++Y ++ + P F + TG + ALL D L+V V DHG P PL +TV
Sbjct: 603 AWLSYRLL--KASEPGLFAVGEHTGEVRTARALLDRDALKQSLVVAVQDHGQP-PLSATV 659
Query: 838 MVNLFVNDTV----SNESYIESLLRKE 860
+ + V D++ ++ +ESL E
Sbjct: 660 TLTVAVADSIPEVLADLGSLESLANSE 686
Score = 85.5 bits (210), Expect = 2e-16
Identities = 75/295 (25%), Positives = 137/295 (46%), Gaps = 23/295 (7%)
Query: 582 FSLDSVTGILTVSTQLDREEK-EKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFI 640
F+++ +G L + ++DREE E ++ + V + ++D NDN+P F
Sbjct: 76 FAVNPRSGSLITAGRIDREELCETVSSCFLNMELLVEDTLKIYGVEVEIIDINDNAPSFQ 135
Query: 641 NKDFSFFVPEN-FPGYG---------EIGVISVTDADAGRNGWVALSVVNQSDIFVIDTG 690
+ V E+ PG ++GV S+ N + +L + ++D
Sbjct: 136 EDEVEIKVSEHAIPGARFALPNARDPDVGVNSLQSYQLSPNNYFSLQLRGRTD----GAK 191
Query: 691 KGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMS 750
L + SLDRE+++++ L + A+DGG+P I +++LD+ND+ P +F QS
Sbjct: 192 NPELVLEGSLDREKEAAHLLLLTALDGGDPIRKGAVPIRVVVLDVNDHIP--MFTQS--V 247
Query: 751 YLLVLPSTL-PGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEA 809
Y + +P + G+ V V A D D G+N + YS E F++D +TG + + +
Sbjct: 248 YRVSVPENISSGTRVLMVNATDPDEGINGEVMYSFRNMESKASEIFQLDSQTGEVQVRGS 307
Query: 810 LLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDT---VSNESYIESLLRKEP 861
L Y + + ++ D G + ++ + VND ++ S I S+L P
Sbjct: 308 LDFEKYRFYEMEIQGQDGGGLFTTTTMLITVVDVNDNAPEITITSSINSILENSP 362
>gi|157426847 protocadherin 19 isoform a [Homo sapiens]
Length = 1101
Score = 276 bits (706), Expect = 7e-74
Identities = 210/684 (30%), Positives = 328/684 (47%), Gaps = 65/684 (9%)
Query: 68 LLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLS 127
L YS+ E AG +I ++A+D R G +P + + S
Sbjct: 25 LKYSVEEEQRAGTVIANVAKDAR-----------------EAGFALDPRQASAFRVVSNS 67
Query: 128 GQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQ 187
++ N S L + Q+IDR+ LC + S C++ L+V+
Sbjct: 68 APHLVDINPSSGLLVTKQKIDRDLLCRQ-----------------SPKCIISLEVMSSSM 110
Query: 188 EYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTY 247
E +K+ I+D+NDNAP FP +QI + + E A TR+ ++ A DPD G GVQTY
Sbjct: 111 E---ICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDS-AYDPDSGSFGVQTY 166
Query: 248 RLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLT 307
L + +F L+++ +G R L+V +LDRETQ Y I A DGG PP LG+ L+
Sbjct: 167 ELTP-NELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLS 225
Query: 308 IGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQAS 367
I ++D NDN P+F++S V+V N+ TP+ + A D D GTN Q+ YS+ V +
Sbjct: 226 IKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRT 285
Query: 368 KDLFHLDENTGVIKLFSKIGGSVLESHKLTILAN--GPGCIPAVITALVSIIKVIFRPPE 425
++LF +D ++G++ + + ++L + A GP IPA VS++ PP
Sbjct: 286 RELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPV 345
Query: 426 IVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEG--KYKVNCYLDGEGPFRLSPYKPY 483
I + +E+ V + E P IA + D + +V C L G PFRL Y+ +
Sbjct: 346 INLLSVNSEL---VEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESF 402
Query: 484 NNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKVQLLDDNDNAPIFLQPLIE 541
+ + +D E Y + + A + + V + D+NDN P F +P +
Sbjct: 403 ST---ILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQ 459
Query: 542 LTIEENNSPNAFLTKLYATDADSEERGQVSYFLGP----DAP--SYFSLDSVTGILTVST 595
+ ++ENN+P A+L + A D D G VSY + P D P +Y S++ +G +
Sbjct: 460 VIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALR 519
Query: 596 QLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDN-----SPRFINKDFSFFVPE 650
+ E+ + + + V A D G P +S ATV + +LD NDN +P IN ++P
Sbjct: 520 SFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPR 579
Query: 651 NFPGYGE-IGVISVTDADAGRNGWVALSVV-NQSDIFVIDTGKGMLRAKVSLDREQQSSY 708
N G G + V+ D D G NG V + F ID G +R + +SSY
Sbjct: 580 N-SGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSY 638
Query: 709 TLWVEAVDGGEPALSSTAKITILL 732
L V A D G+ +LS++A + I L
Sbjct: 639 ELIVVAHDHGKTSLSASALVLIYL 662
Score = 152 bits (385), Expect = 1e-36
Identities = 156/583 (26%), Positives = 250/583 (42%), Gaps = 54/583 (9%)
Query: 306 LTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQ 365
+ + I D+NDN P F +QI + + A+ GT I A D D G+ TY +
Sbjct: 115 IKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPN--- 171
Query: 366 ASKDLFHLDENT-------GVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIK 418
+LF L+ T + + + + I A G P + T +SI K
Sbjct: 172 ---ELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSI-K 227
Query: 419 VIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDP-EGK-----YKVNCYLDGE 472
V + +E V + E P NTP+ DP EG Y Y++
Sbjct: 228 VTDSNDN---NPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDR 284
Query: 473 GP--FRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAW----NSEGFHVKRVIKVQLL 526
F++ P+ L+ T +DYE YE+ V A NS H K + V +L
Sbjct: 285 TRELFQIDPHSG-----LVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCK--VTVSVL 337
Query: 527 DDNDNAPIF--LQPLIELT-IEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFS 583
D NDN P+ L EL + E+ P + + +D DS G+V L + P
Sbjct: 338 DTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQ 397
Query: 584 LDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKD 643
+ V +LDRE+ ++Y T++A D G P +S + + + D+NDN P F
Sbjct: 398 EYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPY 457
Query: 644 FSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVV----NQSDIFV---IDTGKGMLRA 696
+ V EN + +S D D G NG V+ +V +F I+ G + A
Sbjct: 458 YQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYA 517
Query: 697 KVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQ--SNMSYLLV 754
S + EQ ++ V A DGG P+L S A + +++LD+NDN P++ P + + + +
Sbjct: 518 LRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYI 577
Query: 755 LPSTLPGSPVTEVYAVDKDTGMNAVIAYSII-GRRGPRPESFRIDPKTGNITLEEALLQT 813
++ G VT V A D D G N + Y + G RG F ID G + ++
Sbjct: 578 PRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRG----FFEIDQVNGEVRTTRTFGES 633
Query: 814 DYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESL 856
+ L+V DHG L ++ +V ++++ + + + S+
Sbjct: 634 SKSSYELIVVAHDHG-KTSLSASALVLIYLSPALDAQESMGSV 675
Score = 146 bits (368), Expect = 1e-34
Identities = 107/345 (31%), Positives = 162/345 (46%), Gaps = 18/345 (5%)
Query: 520 VIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAP 579
VIKV++ D NDNAP F IEL I E SP + A D DS G +Y L P+
Sbjct: 114 VIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPN-- 171
Query: 580 SYFSLDSVT-------GILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDK 632
F L+ T L V LDRE + Y + + A+D G PPR +++ V D
Sbjct: 172 ELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDS 231
Query: 633 NDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSV---VNQS--DIFVI 687
NDN+P F ++ VPEN P + ++ +D D G NG V S VN ++F I
Sbjct: 232 NDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQI 291
Query: 688 DTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQS 747
D G++ +LD E+ Y L V+A D G ++ + K+T+ +LD NDNPP++
Sbjct: 292 DPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSV 351
Query: 748 NMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLE 807
N + V S PG + V D+D+G+N + ++G R + + I ++
Sbjct: 352 NSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYE---SFSTILVD 408
Query: 808 EALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESY 852
L + + + L ++ D G P L S + + D N +
Sbjct: 409 GRLDREQHDQYNLTIQARDGGVP-MLQSAKSFTVLITDENDNHPH 452
>gi|157426845 protocadherin 19 isoform b [Homo sapiens]
Length = 1100
Score = 276 bits (706), Expect = 7e-74
Identities = 210/684 (30%), Positives = 328/684 (47%), Gaps = 65/684 (9%)
Query: 68 LLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLS 127
L YS+ E AG +I ++A+D R G +P + + S
Sbjct: 25 LKYSVEEEQRAGTVIANVAKDAR-----------------EAGFALDPRQASAFRVVSNS 67
Query: 128 GQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQ 187
++ N S L + Q+IDR+ LC + S C++ L+V+
Sbjct: 68 APHLVDINPSSGLLVTKQKIDRDLLCRQ-----------------SPKCIISLEVMSSSM 110
Query: 188 EYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTY 247
E +K+ I+D+NDNAP FP +QI + + E A TR+ ++ A DPD G GVQTY
Sbjct: 111 E---ICVIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDS-AYDPDSGSFGVQTY 166
Query: 248 RLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLT 307
L + +F L+++ +G R L+V +LDRETQ Y I A DGG PP LG+ L+
Sbjct: 167 ELTP-NELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLS 225
Query: 308 IGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQAS 367
I ++D NDN P+F++S V+V N+ TP+ + A D D GTN Q+ YS+ V +
Sbjct: 226 IKVTDSNDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRT 285
Query: 368 KDLFHLDENTGVIKLFSKIGGSVLESHKLTILAN--GPGCIPAVITALVSIIKVIFRPPE 425
++LF +D ++G++ + + ++L + A GP IPA VS++ PP
Sbjct: 286 RELFQIDPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPV 345
Query: 426 IVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEG--KYKVNCYLDGEGPFRLSPYKPY 483
I + +E+ V + E P IA + D + +V C L G PFRL Y+ +
Sbjct: 346 INLLSVNSEL---VEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYESF 402
Query: 484 NNEYLLETTKPMDYELQQFYEVAVVAWNS--EGFHVKRVIKVQLLDDNDNAPIFLQPLIE 541
+ + +D E Y + + A + + V + D+NDN P F +P +
Sbjct: 403 ST---ILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPYYQ 459
Query: 542 LTIEENNSPNAFLTKLYATDADSEERGQVSYFLGP----DAP--SYFSLDSVTGILTVST 595
+ ++ENN+P A+L + A D D G VSY + P D P +Y S++ +G +
Sbjct: 460 VIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYALR 519
Query: 596 QLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDN-----SPRFINKDFSFFVPE 650
+ E+ + + + V A D G P +S ATV + +LD NDN +P IN ++P
Sbjct: 520 SFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYIPR 579
Query: 651 NFPGYGE-IGVISVTDADAGRNGWVALSVV-NQSDIFVIDTGKGMLRAKVSLDREQQSSY 708
N G G + V+ D D G NG V + F ID G +R + +SSY
Sbjct: 580 N-SGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRGFFEIDQVNGEVRTTRTFGESSKSSY 638
Query: 709 TLWVEAVDGGEPALSSTAKITILL 732
L V A D G+ +LS++A + I L
Sbjct: 639 ELIVVAHDHGKTSLSASALVLIYL 662
Score = 152 bits (385), Expect = 1e-36
Identities = 156/583 (26%), Positives = 250/583 (42%), Gaps = 54/583 (9%)
Query: 306 LTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQ 365
+ + I D+NDN P F +QI + + A+ GT I A D D G+ TY +
Sbjct: 115 IKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPN--- 171
Query: 366 ASKDLFHLDENT-------GVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIK 418
+LF L+ T + + + + I A G P + T +SI K
Sbjct: 172 ---ELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSI-K 227
Query: 419 VIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDP-EGK-----YKVNCYLDGE 472
V + +E V + E P NTP+ DP EG Y Y++
Sbjct: 228 VTDSNDN---NPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDR 284
Query: 473 GP--FRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVAW----NSEGFHVKRVIKVQLL 526
F++ P+ L+ T +DYE YE+ V A NS H K + V +L
Sbjct: 285 TRELFQIDPHSG-----LVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCK--VTVSVL 337
Query: 527 DDNDNAPIF--LQPLIELT-IEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFS 583
D NDN P+ L EL + E+ P + + +D DS G+V L + P
Sbjct: 338 DTNDNPPVINLLSVNSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQ 397
Query: 584 LDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKD 643
+ V +LDRE+ ++Y T++A D G P +S + + + D+NDN P F
Sbjct: 398 EYESFSTILVDGRLDREQHDQYNLTIQARDGGVPMLQSAKSFTVLITDENDNHPHFSKPY 457
Query: 644 FSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVV----NQSDIFV---IDTGKGMLRA 696
+ V EN + +S D D G NG V+ +V +F I+ G + A
Sbjct: 458 YQVIVQENNTPGAYLLSVSARDPDLGLNGSVSYQIVPSQVRDMPVFTYVSINPNSGDIYA 517
Query: 697 KVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQ--SNMSYLLV 754
S + EQ ++ V A DGG P+L S A + +++LD+NDN P++ P + + + +
Sbjct: 518 LRSFNHEQTKAFEFKVLAKDGGLPSLQSNATVRVIILDVNDNTPVITAPPLINGTAEVYI 577
Query: 755 LPSTLPGSPVTEVYAVDKDTGMNAVIAYSII-GRRGPRPESFRIDPKTGNITLEEALLQT 813
++ G VT V A D D G N + Y + G RG F ID G + ++
Sbjct: 578 PRNSGIGYLVTVVKAEDYDEGENGRVTYDMTEGDRG----FFEIDQVNGEVRTTRTFGES 633
Query: 814 DYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESL 856
+ L+V DHG L ++ +V ++++ + + + S+
Sbjct: 634 SKSSYELIVVAHDHG-KTSLSASALVLIYLSPALDAQESMGSV 675
Score = 146 bits (368), Expect = 1e-34
Identities = 107/345 (31%), Positives = 162/345 (46%), Gaps = 18/345 (5%)
Query: 520 VIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAP 579
VIKV++ D NDNAP F IEL I E SP + A D DS G +Y L P+
Sbjct: 114 VIKVEIKDLNDNAPSFPAAQIELEISEAASPGTRIPLDSAYDPDSGSFGVQTYELTPN-- 171
Query: 580 SYFSLDSVT-------GILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDK 632
F L+ T L V LDRE + Y + + A+D G PPR +++ V D
Sbjct: 172 ELFGLEIKTRGDGSRFAELVVEKSLDRETQSHYSFRITALDGGDPPRLGTVGLSIKVTDS 231
Query: 633 NDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSV---VNQS--DIFVI 687
NDN+P F ++ VPEN P + ++ +D D G NG V S VN ++F I
Sbjct: 232 NDNNPVFSESTYAVSVPENSPPNTPVIRLNASDPDEGTNGQVVYSFYGYVNDRTRELFQI 291
Query: 688 DTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQS 747
D G++ +LD E+ Y L V+A D G ++ + K+T+ +LD NDNPP++
Sbjct: 292 DPHSGLVTVTGALDYEEGHVYELDVQAKDLGPNSIPAHCKVTVSVLDTNDNPPVINLLSV 351
Query: 748 NMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLE 807
N + V S PG + V D+D+G+N + ++G R + + I ++
Sbjct: 352 NSELVEVSESAPPGYVIALVRVSDRDSGLNGRVQCRLLGNVPFRLQEYE---SFSTILVD 408
Query: 808 EALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESY 852
L + + + L ++ D G P L S + + D N +
Sbjct: 409 GRLDREQHDQYNLTIQARDGGVP-MLQSAKSFTVLITDENDNHPH 452
>gi|94538350 protocadherin 17 precursor [Homo sapiens]
Length = 1159
Score = 275 bits (703), Expect = 1e-73
Identities = 222/710 (31%), Positives = 322/710 (45%), Gaps = 96/710 (13%)
Query: 68 LLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLS 127
L YS+ E AG +IG++ D RL P PP R S
Sbjct: 21 LNYSVPEEQGAGTVIGNIGRDARLQPGL-------------------PPAERGGGGRSKS 61
Query: 128 GQYVTLDNR----------SGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCL 177
G Y L+N SG L+T Q IDRE+LC C
Sbjct: 62 GSYRVLENSAPHLLDVDADSGLLYTK-QRIDRESLCRHNA-----------------KCQ 103
Query: 178 LLLDVLVLPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDP 237
L L+V +E +K+ I+DINDNAP F QI + + ENA TR + A DP
Sbjct: 104 LSLEVFANDKE---ICMIKVEIQDINDNAPSFSSDQIEMDISENAAPGTRFPLTS-AHDP 159
Query: 238 DVGINGVQTYRLL-DYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGG 296
D G NG++TY L D HG+F LDV+ +G + P L++ ALDRE Q+ + ++ A DGG
Sbjct: 160 DAGENGLRTYLLTRDDHGLFGLDVKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGG 219
Query: 297 SPPLLGSATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQIT 356
PP + + + + D NDN P+F V + NA +GT + + A D D G N ++
Sbjct: 220 EPPRSATVQINVKVIDSNDNSPVFEAPSYLVELPENAPLGTVVIDLNATDADEGPNGEVL 279
Query: 357 YSYSQKVPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILAN--GPGCIPAVITALV 414
YS+S VP ++LF +D TG+I++ + ++ + A GP IPA V
Sbjct: 280 YSFSSYVPDRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCKVTV 339
Query: 415 SIIKVIFRPPEIVPRYIANEIDGVVYLKELEPVNTPIAF--FTIRDPEGKYKVNCYLDGE 472
+I P I + G L E P T IA T RD ++ C + G
Sbjct: 340 KLIDRNDNAPSI---GFVSVRQGA--LSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGG 394
Query: 473 G---------------PFRLSPYKPYNNEYLLETTKPMDYELQQFYEVAVVA--WNSEGF 515
G PF+L + Y+N Y + T +P+D E Q Y V +VA S
Sbjct: 395 GGTGGGGGLGGPGGSVPFKLE--ENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPL 452
Query: 516 HVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLG 575
+ + +++LD+NDN P F + L L + ENN P +L + A D D + G VSY +
Sbjct: 453 NSTKSFAIKILDENDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSIL 512
Query: 576 P------DAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGKPPR-ESVATVALT 628
P +Y S++ G + + E+ + + + V A D G P ES ATV +T
Sbjct: 513 PSHIGDVSIYTYVSVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVT 572
Query: 629 VLDKNDNSPRFI-----NKDFSFFVPENFPGYGE-IGVISVTDADAGRNGWVALSVVNQS 682
VLD NDN+P + N VP N G G + + D+D G +G + +V+ +
Sbjct: 573 VLDVNDNAPVIVLPTLQNDTAELQVPRN-AGLGYLVSTVRALDSDFGESGRLTYEIVDGN 631
Query: 683 D--IFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITI 730
D +F ID G +R + L V+ D G+P LS+ AK+ I
Sbjct: 632 DDHLFEIDPSSGEIRTLHPFWEDVTPVVELVVKVTDHGKPTLSAVAKLII 681
Score = 164 bits (414), Expect = 5e-40
Identities = 201/756 (26%), Positives = 307/756 (40%), Gaps = 114/756 (15%)
Query: 206 APQFPVSQISVWVPENAPVNT------RLAIEHPAVDPDVGINGVQT----YRLLDYHGM 255
AP + ++ VPE T R A P + P G ++ YR+L+
Sbjct: 13 APALTLKNLNYSVPEEQGAGTVIGNIGRDARLQPGLPPAERGGGGRSKSGSYRVLENSAP 72
Query: 256 FTLDVEENENGERTPYLIVMGALDRETQDQYVSI-IIAEDGGSPPLLGSATLTIGISDIN 314
LDV+ + T I +L R +S+ + A D + + I DIN
Sbjct: 73 HLLDVDADSGLLYTKQRIDRESLCRHNAKCQLSLEVFANDKEI------CMIKVEIQDIN 126
Query: 315 DNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLD 374
DN P F+ QI + + NA GT A D D G N TY ++ LF LD
Sbjct: 127 DNAPSFSSDQIEMDISENAAPGTRFPLTSAHDPDAGENGLRTYLLTRD----DHGLFGLD 182
Query: 375 ENTG-------VIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFR----P 423
+ + + + H L + A G P T +++ KVI P
Sbjct: 183 VKSRGDGTKFPELVIQKALDREQQNHHTLVLTALDGGEPPRSATVQINV-KVIDSNDNSP 241
Query: 424 PEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDP-EGKYKVNCYLDGEGPFRLSPYKP 482
P Y+ V L E P+ T + D EG +GE + S Y P
Sbjct: 242 VFEAPSYL-------VELPENAPLGTVVIDLNATDADEGP-------NGEVLYSFSSYVP 287
Query: 483 YN---------NEYLLETTKPMDYELQQFYEVAVVAW----NSEGFHVKRVIKVQLLDDN 529
L+ +DYE E+ V A N H K + V+L+D N
Sbjct: 288 DRVRELFSIDPKTGLIRVKGNLDYEENGMLEIDVQARDLGPNPIPAHCK--VTVKLIDRN 345
Query: 530 DNAP-IFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFL-------------G 575
DNAP I + + + E P + + TD DS + GQ+ + G
Sbjct: 346 DNAPSIGFVSVRQGALSEAAPPGTVIALVRVTDRDSGKNGQLQCRVLGGGGTGGGGGLGG 405
Query: 576 PDAPSYFSLD-SVTGILTVSTQ--LDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDK 632
P F L+ + TV T LDRE +++Y T+ A D G PP S + A+ +LD+
Sbjct: 406 PGGSVPFKLEENYDNFYTVVTDRPLDRETQDEYNVTIVARDGGSPPLNSTKSFAIKILDE 465
Query: 633 NDNSPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQ--SDIFV---- 686
NDN PRF + V EN +G + D D G+NG V+ S++ D+ +
Sbjct: 466 NDNPPRFTKGLYVLQVHENNIPGEYLGSVLAQDPDLGQNGTVSYSILPSHIGDVSIYTYV 525
Query: 687 -IDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA-LSSTAKITILLLDINDNPPLVLF 744
++ G + A S + EQ ++ V A D G PA L S A + + +LD+NDN P+++
Sbjct: 526 SVNPTNGAIYALRSFNFEQTKAFEFKVLAKDSGAPAHLESNATVRVTVLDVNDNAPVIVL 585
Query: 745 P--QSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTG 802
P Q++ + L V + G V+ V A+D D G + + Y I+ G F IDP +G
Sbjct: 586 PTLQNDTAELQVPRNAGLGYLVSTVRALDSDFGESGRLTYEIVD--GNDDHLFEIDPSSG 643
Query: 803 NITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
I + + L+VKV+DHG P S + L+ +
Sbjct: 644 EIRTLHPFWEDVTPVVELVVKVTDHGKP------------------TLSAVAKLIIRSVS 685
Query: 863 INIEEKEPQISIEPTHRKVESVSCMPTLVALSVISL 898
++ E P+++ E H + +P +V LS IS+
Sbjct: 686 GSLPEGVPRVNGEQHHWDMS----LPLIVTLSTISI 717
>gi|8850232 protocadherin gamma subfamily A, 12 isoform 1 precursor
[Homo sapiens]
Length = 932
Score = 275 bits (702), Expect = 2e-73
Identities = 211/690 (30%), Positives = 332/690 (48%), Gaps = 73/690 (10%)
Query: 66 TELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRG 125
T++ YS+ E L G +G ++ DL L PR +L ER + RG
Sbjct: 29 TQIRYSVPEELEKGSRVGDISRDLGLEPR---------ELAER---------GVRIIPRG 70
Query: 126 LSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVL 185
+ Q L+ RSG L T+ + IDRE LC+ G++ C L LD+L+
Sbjct: 71 RT-QLFALNPRSGSLVTAGR-IDREELCM---------GAIK--------CQLNLDILM- 110
Query: 186 PQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQ 245
++ + V++ +RDINDNAP F S++ + + ENA R + H A DPD+G N +Q
Sbjct: 111 -EDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPH-AWDPDIGKNSLQ 168
Query: 246 TYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSAT 305
+Y L + F+L V+ +G + P L++ ALDRE + + ++ A DGG P G+A
Sbjct: 169 SYELSP-NTHFSLIVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTAR 227
Query: 306 LTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQ 365
+ + + D NDN P F + +V N +GT + V A D D G NA++ YS+ + V
Sbjct: 228 IRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSF-RYVDD 286
Query: 366 ASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPE 425
+ +F LD N+G I ++ +++ + A A L++++ V PE
Sbjct: 287 KAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPE 346
Query: 426 IVPRYIANEIDGVVYLKELEPVNTPIAFFTI--RDPEGKYKVNCYLDGEGPFRLSPYKPY 483
+V +A+ + E P T IA + +D E +V C++ G PF+L K Y
Sbjct: 347 VVLTSLASSV------PENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLE--KSY 398
Query: 484 NNEYLLETTKPMDYELQQFYEVAVVAWN--SEGFHVKRVIKVQLLDDNDNAPIFLQPLIE 541
N Y L T +D E Y + V A + + + I + + D NDN P+F Q
Sbjct: 399 GNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYS 458
Query: 542 LTIEENNSPNAFLTKLYATDADSEERGQVSYFL------GPDAPSYFSLDSVTGILTVST 595
I ENN L + A D D EE Q++Y L G SY S++S TG+L +
Sbjct: 459 AYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALS 518
Query: 596 QLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFI--------NKDFSFF 647
D E+ + V A D G PP S +++L VLD+NDN+P + +
Sbjct: 519 SFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELA 578
Query: 648 VPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSD--IFVIDTGKGMLR-AKVSLDREQ 704
PGY V++V D D+G+N W++ ++ S+ +F + G +R A+ LDR+
Sbjct: 579 PRSAEPGYLVTKVVAV-DRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDA 637
Query: 705 QSSYTLWVEAVDGGEPALSSTAKITILLLD 734
+L V D G+P LS+T +T+ + D
Sbjct: 638 LKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 201 bits (512), Expect = 2e-51
Identities = 162/562 (28%), Positives = 252/562 (44%), Gaps = 36/562 (6%)
Query: 308 IGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQK----- 362
+ + DINDN P F +S++ + + NA A D D+G N+ +Y S
Sbjct: 121 VEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSL 180
Query: 363 VPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFR 422
+ Q D E + L + +H L + A+ G TA + ++ +
Sbjct: 181 IVQNGADGSKYPE----LVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDAN 236
Query: 423 ---PPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSP 479
P P Y A+ + + +L VN + + E +Y Y+D +
Sbjct: 237 DNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGV-NAEVRYSFR-YVDDKAA---QV 291
Query: 480 YKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPL 539
+K N + T +D+E FY++ V A ++ G+ + + + +LD NDNAP +
Sbjct: 292 FKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTS 351
Query: 540 IELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTG---ILTVSTQ 596
+ ++ EN+ + L D DSEE GQV F+ + P F L+ G L
Sbjct: 352 LASSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLP--FKLEKSYGNYYSLVTDIV 409
Query: 597 LDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYG 656
LDRE+ Y TV A D G PP + ++L V D NDN P F +S ++PEN P
Sbjct: 410 LDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGV 469
Query: 657 EIGVISVTDADAGRNGWVALSVVNQ-------SDIFVIDTGKGMLRAKVSLDREQQSSYT 709
+ ++ D D N + S+ S I++ G+L A S D EQ
Sbjct: 470 SLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQ 529
Query: 710 LWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFP----QSNMSYLLVLPSTLPGSPVT 765
+ V A D G P LSS +++ +LD NDN P +L+P + L S PG VT
Sbjct: 530 VKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVT 589
Query: 766 EVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVS 825
+V AVD+D+G NA ++Y ++ + P F + TG + ALL D L+V V
Sbjct: 590 KVVAVDRDSGQNAWLSYRLL--KASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQ 647
Query: 826 DHGYPEPLHSTVMVNLFVNDTV 847
DHG P PL +TV + + V D++
Sbjct: 648 DHGQP-PLSATVTLTVAVADSI 668
Score = 90.1 bits (222), Expect = 9e-18
Identities = 80/294 (27%), Positives = 133/294 (45%), Gaps = 23/294 (7%)
Query: 582 FSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCG------KPPRESVATVALTVLDKNDN 635
F+L+ +G L + ++DREE + A+ C + + V + V D NDN
Sbjct: 75 FALNPRSGSLVTAGRIDREE-----LCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDN 129
Query: 636 SPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVA--LSVVNQSDIFVIDTGKGM 693
+P F + + EN + D D G+N + LS + V + G
Sbjct: 130 APYFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGS 189
Query: 694 ----LRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNM 749
L K +LDRE+++++ L + A DGG+P + TA+I +++LD NDN P P+
Sbjct: 190 KYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPE--- 246
Query: 750 SYLLVLPSTLP-GSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEE 808
Y +P L G+ + V A D D G+NA + YS + F++D +G I+
Sbjct: 247 -YRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIG 305
Query: 809 ALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
L + G +++ V+ D+ ++ L VND + E + SL PE
Sbjct: 306 ELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDN-APEVVLTSLASSVPE 358
>gi|14196457 protocadherin gamma subfamily A, 12 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 275 bits (702), Expect = 2e-73
Identities = 211/690 (30%), Positives = 332/690 (48%), Gaps = 73/690 (10%)
Query: 66 TELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRG 125
T++ YS+ E L G +G ++ DL L PR +L ER + RG
Sbjct: 29 TQIRYSVPEELEKGSRVGDISRDLGLEPR---------ELAER---------GVRIIPRG 70
Query: 126 LSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVL 185
+ Q L+ RSG L T+ + IDRE LC+ G++ C L LD+L+
Sbjct: 71 RT-QLFALNPRSGSLVTAGR-IDREELCM---------GAIK--------CQLNLDILM- 110
Query: 186 PQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQ 245
++ + V++ +RDINDNAP F S++ + + ENA R + H A DPD+G N +Q
Sbjct: 111 -EDKVKIYGVEVEVRDINDNAPYFRESELEIKISENAATEMRFPLPH-AWDPDIGKNSLQ 168
Query: 246 TYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSAT 305
+Y L + F+L V+ +G + P L++ ALDRE + + ++ A DGG P G+A
Sbjct: 169 SYELSP-NTHFSLIVQNGADGSKYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTAR 227
Query: 306 LTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQ 365
+ + + D NDN P F + +V N +GT + V A D D G NA++ YS+ + V
Sbjct: 228 IRVMVLDANDNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGVNAEVRYSF-RYVDD 286
Query: 366 ASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPE 425
+ +F LD N+G I ++ +++ + A A L++++ V PE
Sbjct: 287 KAAQVFKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPE 346
Query: 426 IVPRYIANEIDGVVYLKELEPVNTPIAFFTI--RDPEGKYKVNCYLDGEGPFRLSPYKPY 483
+V +A+ + E P T IA + +D E +V C++ G PF+L K Y
Sbjct: 347 VVLTSLASSV------PENSPRGTLIALLNVNDQDSEENGQVICFIQGNLPFKLE--KSY 398
Query: 484 NNEYLLETTKPMDYELQQFYEVAVVAWN--SEGFHVKRVIKVQLLDDNDNAPIFLQPLIE 541
N Y L T +D E Y + V A + + + I + + D NDN P+F Q
Sbjct: 399 GNYYSLVTDIVLDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYS 458
Query: 542 LTIEENNSPNAFLTKLYATDADSEERGQVSYFL------GPDAPSYFSLDSVTGILTVST 595
I ENN L + A D D EE Q++Y L G SY S++S TG+L +
Sbjct: 459 AYIPENNPRGVSLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALS 518
Query: 596 QLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFI--------NKDFSFF 647
D E+ + V A D G PP S +++L VLD+NDN+P + +
Sbjct: 519 SFDYEQFRDLQVKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELA 578
Query: 648 VPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSD--IFVIDTGKGMLR-AKVSLDREQ 704
PGY V++V D D+G+N W++ ++ S+ +F + G +R A+ LDR+
Sbjct: 579 PRSAEPGYLVTKVVAV-DRDSGQNAWLSYRLLKASEPGLFSVGLHTGEVRTARALLDRDA 637
Query: 705 QSSYTLWVEAVDGGEPALSSTAKITILLLD 734
+L V D G+P LS+T +T+ + D
Sbjct: 638 LKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 201 bits (512), Expect = 2e-51
Identities = 162/562 (28%), Positives = 252/562 (44%), Gaps = 36/562 (6%)
Query: 308 IGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQK----- 362
+ + DINDN P F +S++ + + NA A D D+G N+ +Y S
Sbjct: 121 VEVRDINDNAPYFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSL 180
Query: 363 VPQASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFR 422
+ Q D E + L + +H L + A+ G TA + ++ +
Sbjct: 181 IVQNGADGSKYPE----LVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDAN 236
Query: 423 ---PPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEGKYKVNCYLDGEGPFRLSP 479
P P Y A+ + + +L VN + + E +Y Y+D +
Sbjct: 237 DNAPAFAQPEYRASVPENLALGTQLLVVNATDPDEGV-NAEVRYSFR-YVDDKAA---QV 291
Query: 480 YKPYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPL 539
+K N + T +D+E FY++ V A ++ G+ + + + +LD NDNAP +
Sbjct: 292 FKLDCNSGTISTIGELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDNAPEVVLTS 351
Query: 540 IELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSVTG---ILTVSTQ 596
+ ++ EN+ + L D DSEE GQV F+ + P F L+ G L
Sbjct: 352 LASSVPENSPRGTLIALLNVNDQDSEENGQVICFIQGNLP--FKLEKSYGNYYSLVTDIV 409
Query: 597 LDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYG 656
LDRE+ Y TV A D G PP + ++L V D NDN P F +S ++PEN P
Sbjct: 410 LDREQVPSYNITVTATDRGTPPLSTETHISLNVADTNDNPPVFPQASYSAYIPENNPRGV 469
Query: 657 EIGVISVTDADAGRNGWVALSVVNQ-------SDIFVIDTGKGMLRAKVSLDREQQSSYT 709
+ ++ D D N + S+ S I++ G+L A S D EQ
Sbjct: 470 SLVSVTAHDPDCEENAQITYSLAENTIQGASLSSYVSINSDTGVLYALSSFDYEQFRDLQ 529
Query: 710 LWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFP----QSNMSYLLVLPSTLPGSPVT 765
+ V A D G P LSS +++ +LD NDN P +L+P + L S PG VT
Sbjct: 530 VKVMARDNGHPPLSSNVSLSLFVLDQNDNAPEILYPALPTDGSTGVELAPRSAEPGYLVT 589
Query: 766 EVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVS 825
+V AVD+D+G NA ++Y ++ + P F + TG + ALL D L+V V
Sbjct: 590 KVVAVDRDSGQNAWLSYRLL--KASEPGLFSVGLHTGEVRTARALLDRDALKQSLVVAVQ 647
Query: 826 DHGYPEPLHSTVMVNLFVNDTV 847
DHG P PL +TV + + V D++
Sbjct: 648 DHGQP-PLSATVTLTVAVADSI 668
Score = 90.1 bits (222), Expect = 9e-18
Identities = 80/294 (27%), Positives = 133/294 (45%), Gaps = 23/294 (7%)
Query: 582 FSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCG------KPPRESVATVALTVLDKNDN 635
F+L+ +G L + ++DREE + A+ C + + V + V D NDN
Sbjct: 75 FALNPRSGSLVTAGRIDREE-----LCMGAIKCQLNLDILMEDKVKIYGVEVEVRDINDN 129
Query: 636 SPRFINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVA--LSVVNQSDIFVIDTGKGM 693
+P F + + EN + D D G+N + LS + V + G
Sbjct: 130 APYFRESELEIKISENAATEMRFPLPHAWDPDIGKNSLQSYELSPNTHFSLIVQNGADGS 189
Query: 694 ----LRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNM 749
L K +LDRE+++++ L + A DGG+P + TA+I +++LD NDN P P+
Sbjct: 190 KYPELVLKRALDREEKAAHHLVLTASDGGDPVRTGTARIRVMVLDANDNAPAFAQPE--- 246
Query: 750 SYLLVLPSTLP-GSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEE 808
Y +P L G+ + V A D D G+NA + YS + F++D +G I+
Sbjct: 247 -YRASVPENLALGTQLLVVNATDPDEGVNAEVRYSFRYVDDKAAQVFKLDCNSGTISTIG 305
Query: 809 ALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
L + G +++ V+ D+ ++ L VND + E + SL PE
Sbjct: 306 ELDHEESGFYQMEVQAMDNAGYSARAKVLITVLDVNDN-APEVVLTSLASSVPE 358
>gi|11056063 protocadherin gamma subfamily A, 7 isoform 1 precursor
[Homo sapiens]
Length = 932
Score = 274 bits (700), Expect = 3e-73
Identities = 215/692 (31%), Positives = 342/692 (49%), Gaps = 75/692 (10%)
Query: 65 ATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASR 124
A +LYS++E G +G +A+DL L PR +L ER + SR
Sbjct: 28 AGRILYSVSEETDKGSFVGDIAKDLGLEPR---------ELAER---------GVRIISR 69
Query: 125 GLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLV 184
G + Q L+ RSG L T+ + IDRE +C + S CL+ ++L+
Sbjct: 70 GRT-QLFALNQRSGSLVTAGR-IDREEICAQ-----------------SARCLVNFNILM 110
Query: 185 LPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGV 244
++ + + I DINDN P+F +I+V + EN R + A DPDVG N +
Sbjct: 111 --EDKMNLYPIDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSE-AGDPDVGTNSL 167
Query: 245 QTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSA 304
Q+Y+L + F+L V+ ++ + P L++ LDRE + + ++ A DGG PP +A
Sbjct: 168 QSYQLSP-NRHFSLAVQSGDDETKYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTA 226
Query: 305 TLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVP 364
+ + + D+ND+ P+F+ Q VTV N VGT + V A+D D G N ++TYS+ + P
Sbjct: 227 HIQVTVVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITP 286
Query: 365 QASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILA-NGPGCIPAVITALVSIIKVIFRP 423
+ K +FHL+ TG I + +++ + A +GPG + L++++ V
Sbjct: 287 KLPK-MFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTKA-KVLITVLDVNDNA 344
Query: 424 PEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPE-GKY-KVNCYLDGEGPFRLSPYK 481
PE+ +++ I E P+ T IA F ++D + GK +V C + PF+L K
Sbjct: 345 PEVTMTSLSSSI------PEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLE--K 396
Query: 482 PYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRV--IKVQLLDDNDNAPIFLQPL 539
+N Y L TTK +D E Y + + A + + R I +Q+ D NDN P F
Sbjct: 397 SIDNYYRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSS 456
Query: 540 IELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPD----AP--SYFSLDSVTGILTV 593
+ I ENN A + + A D DSE+ Q++Y L D AP SY S++S TG+L
Sbjct: 457 YSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYA 516
Query: 594 STQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFI--------NKDFS 645
D E+ + + V A D G PP S +++L VLD+NDN P + +
Sbjct: 517 LQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGME 576
Query: 646 FFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSD--IFVIDTGKGMLR-AKVSLDR 702
PGY V++V D D+G+N W++ ++ S+ +F + G +R A+ LDR
Sbjct: 577 LAPRSAEPGYLVTKVVAV-DKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARALLDR 635
Query: 703 EQQSSYTLWVEAVDGGEPALSSTAKITILLLD 734
+ +L V D G+P LS+T +T+ + D
Sbjct: 636 DALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 201 bits (512), Expect = 2e-51
Identities = 180/614 (29%), Positives = 276/614 (44%), Gaps = 57/614 (9%)
Query: 267 ERTPYLIVMGALDRE---TQDQYVSI---IIAEDGGSPPLLGSATLTIGISDINDNCPLF 320
+R+ L+ G +DRE Q + I+ ED + + + I DINDN P F
Sbjct: 79 QRSGSLVTAGRIDREEICAQSARCLVNFNILMEDK-----MNLYPIDVEIIDINDNVPRF 133
Query: 321 TDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVI 380
+INV + N G +A D D+GTN+ +Y S S + D+ T
Sbjct: 134 LTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPN-RHFSLAVQSGDDETKYP 192
Query: 381 KLFSK--IGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFR---PPEIVPRYIANEI 435
+L + + H L + A+ G P TA + + V P +P+Y
Sbjct: 193 ELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQY----- 247
Query: 436 DGVVYLKELEPVNTPIAFFTIRD-PEGKYKVNCYLDGEGPF---RLSPYKP---YNNEYL 488
V + E PV T + D EG ++GE + +++P P + N
Sbjct: 248 --QVTVPENVPVGTRLLTVHAIDLDEG-------VNGEVTYSFRKITPKLPKMFHLNSLT 298
Query: 489 --LETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEE 546
+ T + +DYE FYE+ V A + G K + + +LD NDNAP + +I E
Sbjct: 299 GEISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPE 358
Query: 547 NNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYF--SLDSVTGILTVSTQLDREEKEK 604
+ + Y D DS + G+V+ + + P S+D+ ++T LDRE
Sbjct: 359 DTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLVTTKN-LDRETLSL 417
Query: 605 YRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVT 664
Y T++A D G PP + + V D NDN P F + +S ++ EN P I +++
Sbjct: 418 YNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQ 477
Query: 665 DADAGRNGWVALSVVNQ-------SDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDG 717
D D+ N + S+ S I++ G+L A S D EQ L V A D
Sbjct: 478 DHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDS 537
Query: 718 GEPALSSTAKITILLLDINDNPPLVLFP----QSNMSYLLVLPSTLPGSPVTEVYAVDKD 773
G+P LSS +++ +LD NDNPP +L+P + L S PG VT+V AVDKD
Sbjct: 538 GDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEPGYLVTKVVAVDKD 597
Query: 774 TGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPL 833
+G NA ++Y ++ + P F + TG + ALL D L+V V DHG P PL
Sbjct: 598 SGQNAWLSYLLL--KASEPGLFAVGLYTGEVRTARALLDRDALKQSLVVAVQDHGQP-PL 654
Query: 834 HSTVMVNLFVNDTV 847
+TV + + V D++
Sbjct: 655 SATVTLTVAVADSI 668
Score = 95.1 bits (235), Expect = 3e-19
Identities = 81/294 (27%), Positives = 141/294 (47%), Gaps = 23/294 (7%)
Query: 582 FSLDSVTGILTVSTQLDREE--KEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRF 639
F+L+ +G L + ++DREE + R V + + ++ + + ++D NDN PRF
Sbjct: 75 FALNQRSGSLVTAGRIDREEICAQSARCLVN-FNILMEDKMNLYPIDVEIIDINDNVPRF 133
Query: 640 INKDFSFFVPEN------FP----GYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDT 689
+ ++ + + EN FP G ++G S+ N +L+V + D +T
Sbjct: 134 LTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSGDD----ET 189
Query: 690 GKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNM 749
L + LDRE++ + L + A DGG+P SSTA I + ++D+ND+ P+ PQ
Sbjct: 190 KYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQ--- 246
Query: 750 SYLLVLPSTLP-GSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEE 808
Y + +P +P G+ + V+A+D D G+N + YS P+ F ++ TG I+ E
Sbjct: 247 -YQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGEISTLE 305
Query: 809 ALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
L + + + V+ D ++ L VND + E + SL PE
Sbjct: 306 GLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDN-APEVTMTSLSSSIPE 358
>gi|14196477 protocadherin gamma subfamily A, 7 isoform 2 precursor
[Homo sapiens]
Length = 817
Score = 274 bits (700), Expect = 3e-73
Identities = 215/692 (31%), Positives = 342/692 (49%), Gaps = 75/692 (10%)
Query: 65 ATELLYSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASR 124
A +LYS++E G +G +A+DL L PR +L ER + SR
Sbjct: 28 AGRILYSVSEETDKGSFVGDIAKDLGLEPR---------ELAER---------GVRIISR 69
Query: 125 GLSGQYVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLV 184
G + Q L+ RSG L T+ + IDRE +C + S CL+ ++L+
Sbjct: 70 GRT-QLFALNQRSGSLVTAGR-IDREEICAQ-----------------SARCLVNFNILM 110
Query: 185 LPQEYFRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGV 244
++ + + I DINDN P+F +I+V + EN R + A DPDVG N +
Sbjct: 111 --EDKMNLYPIDVEIIDINDNVPRFLTEEINVKIMENTAPGVRFPLSE-AGDPDVGTNSL 167
Query: 245 QTYRLLDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSA 304
Q+Y+L + F+L V+ ++ + P L++ LDRE + + ++ A DGG PP +A
Sbjct: 168 QSYQLSP-NRHFSLAVQSGDDETKYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTA 226
Query: 305 TLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVP 364
+ + + D+ND+ P+F+ Q VTV N VGT + V A+D D G N ++TYS+ + P
Sbjct: 227 HIQVTVVDVNDHTPVFSLPQYQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITP 286
Query: 365 QASKDLFHLDENTGVIKLFSKIGGSVLESHKLTILA-NGPGCIPAVITALVSIIKVIFRP 423
+ K +FHL+ TG I + +++ + A +GPG + L++++ V
Sbjct: 287 KLPK-MFHLNSLTGEISTLEGLDYEETAFYEMEVQAQDGPGSLTKA-KVLITVLDVNDNA 344
Query: 424 PEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPE-GKY-KVNCYLDGEGPFRLSPYK 481
PE+ +++ I E P+ T IA F ++D + GK +V C + PF+L K
Sbjct: 345 PEVTMTSLSSSI------PEDTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLE--K 396
Query: 482 PYNNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRV--IKVQLLDDNDNAPIFLQPL 539
+N Y L TTK +D E Y + + A + + R I +Q+ D NDN P F
Sbjct: 397 SIDNYYRLVTTKNLDRETLSLYNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSS 456
Query: 540 IELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPD----AP--SYFSLDSVTGILTV 593
+ I ENN A + + A D DSE+ Q++Y L D AP SY S++S TG+L
Sbjct: 457 YSVYIAENNPRGASIFLVTAQDHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYA 516
Query: 594 STQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFI--------NKDFS 645
D E+ + + V A D G PP S +++L VLD+NDN P + +
Sbjct: 517 LQSFDYEQLRELQLRVTAHDSGDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGME 576
Query: 646 FFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSD--IFVIDTGKGMLR-AKVSLDR 702
PGY V++V D D+G+N W++ ++ S+ +F + G +R A+ LDR
Sbjct: 577 LAPRSAEPGYLVTKVVAV-DKDSGQNAWLSYLLLKASEPGLFAVGLYTGEVRTARALLDR 635
Query: 703 EQQSSYTLWVEAVDGGEPALSSTAKITILLLD 734
+ +L V D G+P LS+T +T+ + D
Sbjct: 636 DALKQ-SLVVAVQDHGQPPLSATVTLTVAVAD 666
Score = 201 bits (512), Expect = 2e-51
Identities = 180/614 (29%), Positives = 276/614 (44%), Gaps = 57/614 (9%)
Query: 267 ERTPYLIVMGALDRE---TQDQYVSI---IIAEDGGSPPLLGSATLTIGISDINDNCPLF 320
+R+ L+ G +DRE Q + I+ ED + + + I DINDN P F
Sbjct: 79 QRSGSLVTAGRIDREEICAQSARCLVNFNILMEDK-----MNLYPIDVEIIDINDNVPRF 133
Query: 321 TDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTGVI 380
+INV + N G +A D D+GTN+ +Y S S + D+ T
Sbjct: 134 LTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPN-RHFSLAVQSGDDETKYP 192
Query: 381 KLFSK--IGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFR---PPEIVPRYIANEI 435
+L + + H L + A+ G P TA + + V P +P+Y
Sbjct: 193 ELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQY----- 247
Query: 436 DGVVYLKELEPVNTPIAFFTIRD-PEGKYKVNCYLDGEGPF---RLSPYKP---YNNEYL 488
V + E PV T + D EG ++GE + +++P P + N
Sbjct: 248 --QVTVPENVPVGTRLLTVHAIDLDEG-------VNGEVTYSFRKITPKLPKMFHLNSLT 298
Query: 489 --LETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEE 546
+ T + +DYE FYE+ V A + G K + + +LD NDNAP + +I E
Sbjct: 299 GEISTLEGLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDNAPEVTMTSLSSSIPE 358
Query: 547 NNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYF--SLDSVTGILTVSTQLDREEKEK 604
+ + Y D DS + G+V+ + + P S+D+ ++T LDRE
Sbjct: 359 DTPLGTVIALFYLQDRDSGKNGEVTCTIPENLPFKLEKSIDNYYRLVTTKN-LDRETLSL 417
Query: 605 YRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVISVT 664
Y T++A D G PP + + V D NDN P F + +S ++ EN P I +++
Sbjct: 418 YNITLKATDGGTPPLSRETHIFMQVADTNDNPPTFPHSSYSVYIAENNPRGASIFLVTAQ 477
Query: 665 DADAGRNGWVALSVVNQ-------SDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDG 717
D D+ N + S+ S I++ G+L A S D EQ L V A D
Sbjct: 478 DHDSEDNAQITYSLAEDTIQGAPVSSYVSINSDTGVLYALQSFDYEQLRELQLRVTAHDS 537
Query: 718 GEPALSSTAKITILLLDINDNPPLVLFP----QSNMSYLLVLPSTLPGSPVTEVYAVDKD 773
G+P LSS +++ +LD NDNPP +L+P + L S PG VT+V AVDKD
Sbjct: 538 GDPPLSSNMSLSLFVLDQNDNPPEILYPALPTDGSTGMELAPRSAEPGYLVTKVVAVDKD 597
Query: 774 TGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPL 833
+G NA ++Y ++ + P F + TG + ALL D L+V V DHG P PL
Sbjct: 598 SGQNAWLSYLLL--KASEPGLFAVGLYTGEVRTARALLDRDALKQSLVVAVQDHGQP-PL 654
Query: 834 HSTVMVNLFVNDTV 847
+TV + + V D++
Sbjct: 655 SATVTLTVAVADSI 668
Score = 95.1 bits (235), Expect = 3e-19
Identities = 81/294 (27%), Positives = 141/294 (47%), Gaps = 23/294 (7%)
Query: 582 FSLDSVTGILTVSTQLDREE--KEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRF 639
F+L+ +G L + ++DREE + R V + + ++ + + ++D NDN PRF
Sbjct: 75 FALNQRSGSLVTAGRIDREEICAQSARCLVN-FNILMEDKMNLYPIDVEIIDINDNVPRF 133
Query: 640 INKDFSFFVPEN------FP----GYGEIGVISVTDADAGRNGWVALSVVNQSDIFVIDT 689
+ ++ + + EN FP G ++G S+ N +L+V + D +T
Sbjct: 134 LTEEINVKIMENTAPGVRFPLSEAGDPDVGTNSLQSYQLSPNRHFSLAVQSGDD----ET 189
Query: 690 GKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNM 749
L + LDRE++ + L + A DGG+P SSTA I + ++D+ND+ P+ PQ
Sbjct: 190 KYPELVLERVLDREEERVHHLVLTASDGGDPPRSSTAHIQVTVVDVNDHTPVFSLPQ--- 246
Query: 750 SYLLVLPSTLP-GSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEE 808
Y + +P +P G+ + V+A+D D G+N + YS P+ F ++ TG I+ E
Sbjct: 247 -YQVTVPENVPVGTRLLTVHAIDLDEGVNGEVTYSFRKITPKLPKMFHLNSLTGEISTLE 305
Query: 809 ALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPE 862
L + + + V+ D ++ L VND + E + SL PE
Sbjct: 306 GLDYEETAFYEMEVQAQDGPGSLTKAKVLITVLDVNDN-APEVTMTSLSSSIPE 358
>gi|9256600 protocadherin alpha subfamily C, 2 isoform 1 precursor
[Homo sapiens]
Length = 1007
Score = 273 bits (698), Expect = 6e-73
Identities = 223/736 (30%), Positives = 336/736 (45%), Gaps = 84/736 (11%)
Query: 20 ATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFV-GPFSCLGSYSRATELLYSLNEGLPA 78
AT HPRL RP LP L L L + GP A++L YS+ E
Sbjct: 10 ATEHPRL-----RRPMPWLLL--LPLLLLLLLLLPGP--------AASQLRYSVPEEQAP 54
Query: 79 GVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQYVTLDNRSG 138
G L+G++A L L R G P GA S +Y+ LD SG
Sbjct: 55 GALVGNVARALGLELRRLG---PGCLRINHLGAP--------------SPRYLELDLTSG 97
Query: 139 ELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFRFVKVKIA 198
L + + IDREALC + CLL L+VL V++
Sbjct: 98 ALFVN-ERIDREALCEQ-----------------RPRCLLSLEVLA--HNPVAVSAVEVE 137
Query: 199 IRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTL 258
I DINDN+P+FP + V E+ R IE A DPDVG N VQTY L F L
Sbjct: 138 ILDINDNSPRFPRPNYQLQVSESVAPGARFHIES-AQDPDVGANSVQTYELSPSEH-FEL 195
Query: 259 DVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCP 318
D++ + + L++ LDRE + ++ A DGG P G+A +++ + D NDN P
Sbjct: 196 DLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSP 255
Query: 319 LFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTG 378
F S V + ++ GT + + A D D G+N ++ YS S + LF +D +TG
Sbjct: 256 AFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTG 315
Query: 379 VIKLFSKIGGSVLESHKLTILANGPGCIPAV--ITALVSIIKVIFRPPEIVPRYIANEID 436
+++ + S+++ + A G +P LV I+ V PE+V + + +
Sbjct: 316 EVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPV- 374
Query: 437 GVVYLKELEPVNTPIAFFTIRDPEG--KYKVNCYLDGEGPFRLSPYKPYNNEYLLETTKP 494
E NT +A ++ D + KV+ L+ PFRL+ + N Y L + P
Sbjct: 375 -----PENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLN---GFGNSYTLVVSGP 426
Query: 495 MDYELQQFYEVAVVAWNS--EGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNA 552
+D E Y + V A + R +KV++ D NDN P FL+ + I+ENN P
Sbjct: 427 LDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGV 486
Query: 553 FLTKLYATDADSEERGQVSYFL------GPDAPSYFSLDSVTGILTVSTQLDREEKEKYR 606
L + ATD D +E +V+Y L G SY S++S +G L D E+ ++
Sbjct: 487 LLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFF 546
Query: 607 YTVRAVDCGKPPRESVATVALTVLDKNDNSPRFI-----NKDFSF-FVPENFPGYGEIGV 660
TV A D G PP S T + V+D ND++P + N +F VP P +
Sbjct: 547 VTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTK 606
Query: 661 ISVTDADAGRNGWV--ALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGG 718
+ D+D+G+N W+ L+ + D+F ++ G +R + E S++ L V D G
Sbjct: 607 VIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNG 666
Query: 719 EPALSSTAKITILLLD 734
EP+LS++ IT+ ++D
Sbjct: 667 EPSLSASVAITVAVVD 682
Score = 172 bits (436), Expect = 1e-42
Identities = 187/678 (27%), Positives = 288/678 (42%), Gaps = 68/678 (10%)
Query: 304 ATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKV 363
+ + + I DINDN P F + V + G A D D+G N+ TY S
Sbjct: 132 SAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPS- 190
Query: 364 PQASKDLFHLDENTGVIKLFSKIGGSVLES--HKLTILANGPGCIPAVITALVSIIKVIF 421
DL L EN+ V++L + G ++ H L + A G TA +S+ +
Sbjct: 191 EHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVR--VL 248
Query: 422 RPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDP-EGKYKVNCYLDGEGPFRLSPY 480
+ P + ++ V L+E P T + DP EG +GE + LS Y
Sbjct: 249 DTNDNSPAF--DQSTYRVQLREDSPPGTLVVKLNASDPDEGS-------NGELRYSLSSY 299
Query: 481 KPYNNEYLLETTKP---------MDYELQQFYEVAVVAWNSEGF----HVKRVIKVQLLD 527
L +DYE Y++ V A + H K + V ++D
Sbjct: 300 TSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCK--VLVDIVD 357
Query: 528 DNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSV 587
NDNAP + + + EN +PN + L D DS +VS LG +A F L+
Sbjct: 358 VNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVS--LGLEATLPFRLNGF 415
Query: 588 TG--ILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFS 645
L VS LDRE Y TV A D G P S+ T+ + + D NDN P F+ +S
Sbjct: 416 GNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYS 475
Query: 646 FFVPEN-FPGYGEIGVISVTDADAGRNGWVALSVVNQ-------SDIFVIDTGKGMLRAK 697
++ EN PG + + TD D N V S++ + + I++ G L A
Sbjct: 476 IYIQENNLPGV-LLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAV 534
Query: 698 VSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLL--VL 755
S D E+ + + VEA D G P LSST + ++D+ND+ P +L+P S S ++
Sbjct: 535 NSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMV 594
Query: 756 PSTLP-GSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTD 814
P T P G VT+V A+D D+G NA + Y + + + F+++ TG I +
Sbjct: 595 PRTAPAGYLVTKVIAMDSDSGQNAWLFYHL--AQTSDLDLFKVELHTGEIRTTRKMGDES 652
Query: 815 YGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISI 874
L V V D+G P L ++V + + V D VS + P+ K P+
Sbjct: 653 GSTFNLTVVVRDNGEPS-LSASVAITVAVVDRVS---------KILPDTQRHVKSPRTYS 702
Query: 875 EPTHRKVESVSCMPTLVALSVISLGSITL--VTGMGIYIC--------LRKGEKHPREDE 924
E T + ++S + + L++I L I T G C E + + +
Sbjct: 703 EITLYLIIALSTVSFIFLLTIIILSIIKCYRYTAYGTACCGGFCGVRERSPAELYKQANN 762
Query: 925 NLEVQIPLKGKIDLHMRE 942
N++ +IP K+ H E
Sbjct: 763 NIDARIPHGLKVQPHFIE 780
Score = 45.8 bits (107), Expect = 2e-04
Identities = 50/174 (28%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 687 IDTGKGMLRAKVSLDRE----QQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLV 742
+D G L +DRE Q+ L +E + A+S+ + + +LDINDN P
Sbjct: 92 LDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSA---VEVEILDINDNSP-- 146
Query: 743 LFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRID---- 798
FP+ N L V S PG+ A D D G N+V Y + E F +D
Sbjct: 147 RFPRPNYQ-LQVSESVAPGARFHIESAQDPDVGANSVQTYEL-----SPSEHFELDLKPL 200
Query: 799 ---PKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSN 849
K + L + L + LH L++ D G P T +++ V DT N
Sbjct: 201 QENSKVLELVLRKGLDREQAALHHLVLTAVDGGIP-ARSGTAQISVRVLDTNDN 253
>gi|14165431 protocadherin alpha subfamily C, 2 isoform 2 precursor
[Homo sapiens]
Length = 884
Score = 273 bits (698), Expect = 6e-73
Identities = 223/736 (30%), Positives = 336/736 (45%), Gaps = 84/736 (11%)
Query: 20 ATWHPRLDMGRLHRPRSSTSYRNLPHLFLFFLFV-GPFSCLGSYSRATELLYSLNEGLPA 78
AT HPRL RP LP L L L + GP A++L YS+ E
Sbjct: 10 ATEHPRL-----RRPMPWLLL--LPLLLLLLLLLPGP--------AASQLRYSVPEEQAP 54
Query: 79 GVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQYVTLDNRSG 138
G L+G++A L L R G P GA S +Y+ LD SG
Sbjct: 55 GALVGNVARALGLELRRLG---PGCLRINHLGAP--------------SPRYLELDLTSG 97
Query: 139 ELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEYFRFVKVKIA 198
L + + IDREALC + CLL L+VL V++
Sbjct: 98 ALFVN-ERIDREALCEQ-----------------RPRCLLSLEVLA--HNPVAVSAVEVE 137
Query: 199 IRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRLLDYHGMFTL 258
I DINDN+P+FP + V E+ R IE A DPDVG N VQTY L F L
Sbjct: 138 ILDINDNSPRFPRPNYQLQVSESVAPGARFHIES-AQDPDVGANSVQTYELSPSEH-FEL 195
Query: 259 DVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGISDINDNCP 318
D++ + + L++ LDRE + ++ A DGG P G+A +++ + D NDN P
Sbjct: 196 DLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVRVLDTNDNSP 255
Query: 319 LFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKDLFHLDENTG 378
F S V + ++ GT + + A D D G+N ++ YS S + LF +D +TG
Sbjct: 256 AFDQSTYRVQLREDSPPGTLVVKLNASDPDEGSNGELRYSLSSYTSDRERQLFSIDASTG 315
Query: 379 VIKLFSKIGGSVLESHKLTILANGPGCIPAV--ITALVSIIKVIFRPPEIVPRYIANEID 436
+++ + S+++ + A G +P LV I+ V PE+V + + +
Sbjct: 316 EVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCKVLVDIVDVNDNAPEVVLTDLYSPV- 374
Query: 437 GVVYLKELEPVNTPIAFFTIRDPEG--KYKVNCYLDGEGPFRLSPYKPYNNEYLLETTKP 494
E NT +A ++ D + KV+ L+ PFRL+ + N Y L + P
Sbjct: 375 -----PENATPNTIVAVLSVNDQDSGPNRKVSLGLEATLPFRLN---GFGNSYTLVVSGP 426
Query: 495 MDYELQQFYEVAVVAWNS--EGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIEENNSPNA 552
+D E Y + V A + R +KV++ D NDN P FL+ + I+ENN P
Sbjct: 427 LDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYSIYIQENNLPGV 486
Query: 553 FLTKLYATDADSEERGQVSYFL------GPDAPSYFSLDSVTGILTVSTQLDREEKEKYR 606
L + ATD D +E +V+Y L G SY S++S +G L D E+ ++
Sbjct: 487 LLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAVNSFDYEKFREFF 546
Query: 607 YTVRAVDCGKPPRESVATVALTVLDKNDNSPRFI-----NKDFSF-FVPENFPGYGEIGV 660
TV A D G PP S T + V+D ND++P + N +F VP P +
Sbjct: 547 VTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMVPRTAPAGYLVTK 606
Query: 661 ISVTDADAGRNGWV--ALSVVNQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGG 718
+ D+D+G+N W+ L+ + D+F ++ G +R + E S++ L V D G
Sbjct: 607 VIAMDSDSGQNAWLFYHLAQTSDLDLFKVELHTGEIRTTRKMGDESGSTFNLTVVVRDNG 666
Query: 719 EPALSSTAKITILLLD 734
EP+LS++ IT+ ++D
Sbjct: 667 EPSLSASVAITVAVVD 682
Score = 172 bits (436), Expect = 1e-42
Identities = 187/678 (27%), Positives = 288/678 (42%), Gaps = 68/678 (10%)
Query: 304 ATLTIGISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKV 363
+ + + I DINDN P F + V + G A D D+G N+ TY S
Sbjct: 132 SAVEVEILDINDNSPRFPRPNYQLQVSESVAPGARFHIESAQDPDVGANSVQTYELSPS- 190
Query: 364 PQASKDLFHLDENTGVIKLFSKIGGSVLES--HKLTILANGPGCIPAVITALVSIIKVIF 421
DL L EN+ V++L + G ++ H L + A G TA +S+ +
Sbjct: 191 EHFELDLKPLQENSKVLELVLRKGLDREQAALHHLVLTAVDGGIPARSGTAQISVR--VL 248
Query: 422 RPPEIVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDP-EGKYKVNCYLDGEGPFRLSPY 480
+ P + ++ V L+E P T + DP EG +GE + LS Y
Sbjct: 249 DTNDNSPAF--DQSTYRVQLREDSPPGTLVVKLNASDPDEGS-------NGELRYSLSSY 299
Query: 481 KPYNNEYLLETTKP---------MDYELQQFYEVAVVAWNSEGF----HVKRVIKVQLLD 527
L +DYE Y++ V A + H K + V ++D
Sbjct: 300 TSDRERQLFSIDASTGEVRVIGGLDYEEASSYQIYVQATDRGPVPMAGHCK--VLVDIVD 357
Query: 528 DNDNAPIFLQPLIELTIEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAPSYFSLDSV 587
NDNAP + + + EN +PN + L D DS +VS LG +A F L+
Sbjct: 358 VNDNAPEVVLTDLYSPVPENATPNTIVAVLSVNDQDSGPNRKVS--LGLEATLPFRLNGF 415
Query: 588 TG--ILTVSTQLDREEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFS 645
L VS LDRE Y TV A D G P S+ T+ + + D NDN P F+ +S
Sbjct: 416 GNSYTLVVSGPLDRERVAVYNITVTATDGGIPQLTSLRTLKVEISDINDNPPSFLEDSYS 475
Query: 646 FFVPEN-FPGYGEIGVISVTDADAGRNGWVALSVVNQ-------SDIFVIDTGKGMLRAK 697
++ EN PG + + TD D N V S++ + + I++ G L A
Sbjct: 476 IYIQENNLPGV-LLCTVQATDPDEKENAEVTYSLLEREIQGLPVTSYVSINSASGSLYAV 534
Query: 698 VSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSYLL--VL 755
S D E+ + + VEA D G P LSST + ++D+ND+ P +L+P S S ++
Sbjct: 535 NSFDYEKFREFFVTVEAQDKGSPPLSSTVTANVYVVDMNDHAPHILYPTSTNSSAAFEMV 594
Query: 756 PSTLP-GSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTD 814
P T P G VT+V A+D D+G NA + Y + + + F+++ TG I +
Sbjct: 595 PRTAPAGYLVTKVIAMDSDSGQNAWLFYHL--AQTSDLDLFKVELHTGEIRTTRKMGDES 652
Query: 815 YGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISI 874
L V V D+G P L ++V + + V D VS + P+ K P+
Sbjct: 653 GSTFNLTVVVRDNGEPS-LSASVAITVAVVDRVS---------KILPDTQRHVKSPRTYS 702
Query: 875 EPTHRKVESVSCMPTLVALSVISLGSITL--VTGMGIYIC--------LRKGEKHPREDE 924
E T + ++S + + L++I L I T G C E + + +
Sbjct: 703 EITLYLIIALSTVSFIFLLTIIILSIIKCYRYTAYGTACCGGFCGVRERSPAELYKQANN 762
Query: 925 NLEVQIPLKGKIDLHMRE 942
N++ +IP K+ H E
Sbjct: 763 NIDARIPHGLKVQPHFIE 780
Score = 45.8 bits (107), Expect = 2e-04
Identities = 50/174 (28%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 687 IDTGKGMLRAKVSLDRE----QQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLV 742
+D G L +DRE Q+ L +E + A+S+ + + +LDINDN P
Sbjct: 92 LDLTSGALFVNERIDREALCEQRPRCLLSLEVLAHNPVAVSA---VEVEILDINDNSP-- 146
Query: 743 LFPQSNMSYLLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRID---- 798
FP+ N L V S PG+ A D D G N+V Y + E F +D
Sbjct: 147 RFPRPNYQ-LQVSESVAPGARFHIESAQDPDVGANSVQTYEL-----SPSEHFELDLKPL 200
Query: 799 ---PKTGNITLEEALLQTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSN 849
K + L + L + LH L++ D G P T +++ V DT N
Sbjct: 201 QENSKVLELVLRKGLDREQAALHHLVLTAVDGGIP-ARSGTAQISVRVLDTNDN 253
>gi|11128029 protocadherin gamma subfamily B, 6 isoform 1 precursor
[Homo sapiens]
Length = 930
Score = 272 bits (696), Expect = 9e-73
Identities = 214/718 (29%), Positives = 343/718 (47%), Gaps = 82/718 (11%)
Query: 70 YSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQ 129
YS+ E L G ++G+LA+DL L S R AE L FS+
Sbjct: 35 YSIPEELAKGSVVGNLAKDLGLSVLDV------SARKLRVSAE---KLHFSV-------- 77
Query: 130 YVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEY 189
D SG+L IDRE +C E C L L+ +V +
Sbjct: 78 ----DAESGDLLVK-NRIDREQICKE-----------------RRRCELQLEAVV--ENP 113
Query: 190 FRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRL 249
V + I D+ND+APQF +I + + E+A TRL+++ PA DPD+ IN ++ Y++
Sbjct: 114 LNIFHVIVVIEDVNDHAPQFDKKEIHLEIFESASAGTRLSLD-PATDPDININSIKDYKI 172
Query: 250 LDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIG 309
+ + F+L V N +G + P L + LDRE Q + I+ A DGG PP +A + I
Sbjct: 173 -NSNPYFSLMVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEIS 231
Query: 310 ISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKD 369
+ D NDN P+F+ + +++ N G+P+ V A D+D G NA+I Y Y + Q++K
Sbjct: 232 VKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINY-YFRSTAQSTKH 290
Query: 370 LFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPR 429
+F LDE TG+IK +E + + + A G + ++ I+ PEI+
Sbjct: 291 MFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDNSPEIIIT 350
Query: 430 YIANEIDGVVYLKELEPVNTPIAFFTIRDPE--GKYKVNCYLDGEGPFRLSPYKPYNNEY 487
++++I E P +A F RD + G +V C ++ + PF++ Y NN Y
Sbjct: 351 SLSDQI------LENSPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKI--YSSSNNYY 402
Query: 488 LLETTKPMDYELQQFYEVAVVAWN--SEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIE 545
L T +D E Y V +VA + R I + + D NDNAP+F Q + +
Sbjct: 403 KLVTDGALDREQTPEYNVTIVATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVA 462
Query: 546 ENNSPNAFLTKLYATDADSEERGQVSYFLGPD------APSYFSLDSVTGILTVSTQLDR 599
ENN P A + ++ A+D D G +SY + SY S+ + +G++ D
Sbjct: 463 ENNPPGASIAQVSASDPDLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDH 522
Query: 600 EEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFI-------NKDFSFFVPENF 652
E+ + T++A D G P + ++ + V D+NDN+PR + F VP +
Sbjct: 523 EQLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSA 582
Query: 653 -PGYGEIGVISVTDADAGRNGWVALSVVNQSD--IFVIDTGKGMLRAKVSLDREQQSSYT 709
PGY V++V DAD+G N W++ V+ S+ +F + G +R +L +
Sbjct: 583 EPGYLVTKVVAV-DADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQR 641
Query: 710 LWVEAVDGGEPALSSTAKITI--------LLLDINDNPPLVLFPQSNMSYLLVLPSTL 759
L V DGG+P LS+TA + + +L D++D P++ PQ+ + + LV+ L
Sbjct: 642 LLVAVRDGGQPPLSATATLHLVFADNLQEILPDLSDR-PVLSDPQAELQFYLVVALAL 698
Score = 194 bits (493), Expect = 3e-49
Identities = 164/607 (27%), Positives = 270/607 (44%), Gaps = 46/607 (7%)
Query: 310 ISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKD 369
I D+ND+ P F +I++ ++ +A+ GT ++ A D D+ N+ Y + P S
Sbjct: 123 IEDVNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKINSN-PYFSL- 180
Query: 370 LFHLDENTGV---IKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSI-IKVIFRPPE 425
+ ++ + G + L + SH L + A G P TA + I +K P
Sbjct: 181 MVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPP 240
Query: 426 IVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEG--KYKVNCYLDGEGPFRLSPYKPY 483
+ R + + L E P +P+ T D + ++N Y +
Sbjct: 241 VFSRD-----EYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLD 295
Query: 484 NNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELT 543
+++ + D+E + Y + V A + G + + +++LD+NDN+P + +
Sbjct: 296 EKTGMIKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDNSPEIIITSLSDQ 355
Query: 544 IEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAP-SYFSLDSVTGILTVSTQLDREEK 602
I EN+ P + D D G+V + D P +S + L LDRE+
Sbjct: 356 ILENSPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNYYKLVTDGALDREQT 415
Query: 603 EKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVIS 662
+Y T+ A D GKPP S ++ L V D NDN+P F + V EN P I +S
Sbjct: 416 PEYNVTIVATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVS 475
Query: 663 VTDADAGRNGWVALSVVNQ-------SDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAV 715
+D D G NG ++ S+V S + G++ A+ + D EQ ++ L ++A
Sbjct: 476 ASDPDLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQAR 535
Query: 716 DGGEPALSSTAKITILLLDINDNPPLVLFP----QSNMSYLLVLPSTLPGSPVTEVYAVD 771
D G P LS+ + +L+ D NDN P VL+P + + +V S PG VT+V AVD
Sbjct: 536 DHGSPTLSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVD 595
Query: 772 KDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPE 831
D+G NA ++Y ++ + P F + +TG + AL D RLLV V D G P
Sbjct: 596 ADSGHNAWLSYHVL--QASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQP- 652
Query: 832 PLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTLV 891
PL +T ++L D N++E P +S P ++ +V
Sbjct: 653 PLSATATLHLVFAD------------------NLQEILPDLSDRPVLSDPQAELQFYLVV 694
Query: 892 ALSVISL 898
AL++IS+
Sbjct: 695 ALALISV 701
Score = 105 bits (261), Expect = 3e-22
Identities = 89/285 (31%), Positives = 139/285 (48%), Gaps = 15/285 (5%)
Query: 581 YFSLDSVTGILTVSTQLDREE--KEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPR 638
+FS+D+ +G L V ++DRE+ KE+ R ++ + P ++ V + + D ND++P+
Sbjct: 74 HFSVDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPL-NIFHVIVVIEDVNDHAPQ 132
Query: 639 FINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVI------DTGK- 691
F K+ + E+ + + TD D N + +N + F + D GK
Sbjct: 133 FDKKEIHLEIFESASAGTRLSLDPATDPDININS-IKDYKINSNPYFSLMVRVNSDGGKY 191
Query: 692 GMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSY 751
L + LDRE+Q S++L + A+DGG+P S+TA I I + D NDNPP+ + +S
Sbjct: 192 PELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRISL 251
Query: 752 LLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALL 811
LP PGSPV +V A D+D G+NA I Y F +D KTG I ++
Sbjct: 252 SENLP---PGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGMIKNNQSFD 308
Query: 812 QTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESL 856
D + + V+ D G ++ L ND S E I SL
Sbjct: 309 FEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDN-SPEIIITSL 352
>gi|14270502 protocadherin gamma subfamily B, 6 isoform 2 precursor
[Homo sapiens]
Length = 820
Score = 272 bits (696), Expect = 9e-73
Identities = 214/718 (29%), Positives = 343/718 (47%), Gaps = 82/718 (11%)
Query: 70 YSLNEGLPAGVLIGSLAEDLRLLPRSAGRPDPQSQLPERTGAEWNPPLSFSLASRGLSGQ 129
YS+ E L G ++G+LA+DL L S R AE L FS+
Sbjct: 35 YSIPEELAKGSVVGNLAKDLGLSVLDV------SARKLRVSAE---KLHFSV-------- 77
Query: 130 YVTLDNRSGELHTSAQEIDREALCVEGGGGTAWSGSVSISSSPSDSCLLLLDVLVLPQEY 189
D SG+L IDRE +C E C L L+ +V +
Sbjct: 78 ----DAESGDLLVK-NRIDREQICKE-----------------RRRCELQLEAVV--ENP 113
Query: 190 FRFVKVKIAIRDINDNAPQFPVSQISVWVPENAPVNTRLAIEHPAVDPDVGINGVQTYRL 249
V + I D+ND+APQF +I + + E+A TRL+++ PA DPD+ IN ++ Y++
Sbjct: 114 LNIFHVIVVIEDVNDHAPQFDKKEIHLEIFESASAGTRLSLD-PATDPDININSIKDYKI 172
Query: 250 LDYHGMFTLDVEENENGERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIG 309
+ + F+L V N +G + P L + LDRE Q + I+ A DGG PP +A + I
Sbjct: 173 -NSNPYFSLMVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEIS 231
Query: 310 ISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKD 369
+ D NDN P+F+ + +++ N G+P+ V A D+D G NA+I Y Y + Q++K
Sbjct: 232 VKDTNDNPPVFSRDEYRISLSENLPPGSPVLQVTATDQDEGVNAEINY-YFRSTAQSTKH 290
Query: 370 LFHLDENTGVIKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSIIKVIFRPPEIVPR 429
+F LDE TG+IK +E + + + A G + ++ I+ PEI+
Sbjct: 291 MFSLDEKTGMIKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDNSPEIIIT 350
Query: 430 YIANEIDGVVYLKELEPVNTPIAFFTIRDPE--GKYKVNCYLDGEGPFRLSPYKPYNNEY 487
++++I E P +A F RD + G +V C ++ + PF++ Y NN Y
Sbjct: 351 SLSDQI------LENSPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKI--YSSSNNYY 402
Query: 488 LLETTKPMDYELQQFYEVAVVAWN--SEGFHVKRVIKVQLLDDNDNAPIFLQPLIELTIE 545
L T +D E Y V +VA + R I + + D NDNAP+F Q + +
Sbjct: 403 KLVTDGALDREQTPEYNVTIVATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVA 462
Query: 546 ENNSPNAFLTKLYATDADSEERGQVSYFLGPD------APSYFSLDSVTGILTVSTQLDR 599
ENN P A + ++ A+D D G +SY + SY S+ + +G++ D
Sbjct: 463 ENNPPGASIAQVSASDPDLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDH 522
Query: 600 EEKEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFI-------NKDFSFFVPENF 652
E+ + T++A D G P + ++ + V D+NDN+PR + F VP +
Sbjct: 523 EQLRAFALTLQARDHGSPTLSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSA 582
Query: 653 -PGYGEIGVISVTDADAGRNGWVALSVVNQSD--IFVIDTGKGMLRAKVSLDREQQSSYT 709
PGY V++V DAD+G N W++ V+ S+ +F + G +R +L +
Sbjct: 583 EPGYLVTKVVAV-DADSGHNAWLSYHVLQASEPGLFSLGLRTGEVRTARALGDRDAARQR 641
Query: 710 LWVEAVDGGEPALSSTAKITI--------LLLDINDNPPLVLFPQSNMSYLLVLPSTL 759
L V DGG+P LS+TA + + +L D++D P++ PQ+ + + LV+ L
Sbjct: 642 LLVAVRDGGQPPLSATATLHLVFADNLQEILPDLSDR-PVLSDPQAELQFYLVVALAL 698
Score = 194 bits (493), Expect = 3e-49
Identities = 164/607 (27%), Positives = 270/607 (44%), Gaps = 46/607 (7%)
Query: 310 ISDINDNCPLFTDSQINVTVYGNATVGTPIAAVQAVDKDLGTNAQITYSYSQKVPQASKD 369
I D+ND+ P F +I++ ++ +A+ GT ++ A D D+ N+ Y + P S
Sbjct: 123 IEDVNDHAPQFDKKEIHLEIFESASAGTRLSLDPATDPDININSIKDYKINSN-PYFSL- 180
Query: 370 LFHLDENTGV---IKLFSKIGGSVLESHKLTILANGPGCIPAVITALVSI-IKVIFRPPE 425
+ ++ + G + L + SH L + A G P TA + I +K P
Sbjct: 181 MVRVNSDGGKYPELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPP 240
Query: 426 IVPRYIANEIDGVVYLKELEPVNTPIAFFTIRDPEG--KYKVNCYLDGEGPFRLSPYKPY 483
+ R + + L E P +P+ T D + ++N Y +
Sbjct: 241 VFSRD-----EYRISLSENLPPGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLD 295
Query: 484 NNEYLLETTKPMDYELQQFYEVAVVAWNSEGFHVKRVIKVQLLDDNDNAPIFLQPLIELT 543
+++ + D+E + Y + V A + G + + +++LD+NDN+P + +
Sbjct: 296 EKTGMIKNNQSFDFEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDNSPEIIITSLSDQ 355
Query: 544 IEENNSPNAFLTKLYATDADSEERGQVSYFLGPDAP-SYFSLDSVTGILTVSTQLDREEK 602
I EN+ P + D D G+V + D P +S + L LDRE+
Sbjct: 356 ILENSPPGMVVALFKTRDLDFGGNGEVRCNIETDIPFKIYSSSNNYYKLVTDGALDREQT 415
Query: 603 EKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPRFINKDFSFFVPENFPGYGEIGVIS 662
+Y T+ A D GKPP S ++ L V D NDN+P F + V EN P I +S
Sbjct: 416 PEYNVTIVATDRGKPPLSSSRSITLYVADINDNAPVFDQTSYVVHVAENNPPGASIAQVS 475
Query: 663 VTDADAGRNGWVALSVVNQ-------SDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAV 715
+D D G NG ++ S+V S + G++ A+ + D EQ ++ L ++A
Sbjct: 476 ASDPDLGLNGHISYSIVASDLEPLAVSSYVSVSAQSGVVFAQRAFDHEQLRAFALTLQAR 535
Query: 716 DGGEPALSSTAKITILLLDINDNPPLVLFP----QSNMSYLLVLPSTLPGSPVTEVYAVD 771
D G P LS+ + +L+ D NDN P VL+P + + +V S PG VT+V AVD
Sbjct: 536 DHGSPTLSANVSLRVLVGDRNDNAPRVLYPALGPDGSAFFDMVPRSAEPGYLVTKVVAVD 595
Query: 772 KDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPE 831
D+G NA ++Y ++ + P F + +TG + AL D RLLV V D G P
Sbjct: 596 ADSGHNAWLSYHVL--QASEPGLFSLGLRTGEVRTARALGDRDAARQRLLVAVRDGGQP- 652
Query: 832 PLHSTVMVNLFVNDTVSNESYIESLLRKEPEINIEEKEPQISIEPTHRKVESVSCMPTLV 891
PL +T ++L D N++E P +S P ++ +V
Sbjct: 653 PLSATATLHLVFAD------------------NLQEILPDLSDRPVLSDPQAELQFYLVV 694
Query: 892 ALSVISL 898
AL++IS+
Sbjct: 695 ALALISV 701
Score = 105 bits (261), Expect = 3e-22
Identities = 89/285 (31%), Positives = 139/285 (48%), Gaps = 15/285 (5%)
Query: 581 YFSLDSVTGILTVSTQLDREE--KEKYRYTVRAVDCGKPPRESVATVALTVLDKNDNSPR 638
+FS+D+ +G L V ++DRE+ KE+ R ++ + P ++ V + + D ND++P+
Sbjct: 74 HFSVDAESGDLLVKNRIDREQICKERRRCELQLEAVVENPL-NIFHVIVVIEDVNDHAPQ 132
Query: 639 FINKDFSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVVNQSDIFVI------DTGK- 691
F K+ + E+ + + TD D N + +N + F + D GK
Sbjct: 133 FDKKEIHLEIFESASAGTRLSLDPATDPDININS-IKDYKINSNPYFSLMVRVNSDGGKY 191
Query: 692 GMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTAKITILLLDINDNPPLVLFPQSNMSY 751
L + LDRE+Q S++L + A+DGG+P S+TA I I + D NDNPP+ + +S
Sbjct: 192 PELSLEKLLDREEQRSHSLILTALDGGDPPRSATAHIEISVKDTNDNPPVFSRDEYRISL 251
Query: 752 LLVLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGRRGPRPESFRIDPKTGNITLEEALL 811
LP PGSPV +V A D+D G+NA I Y F +D KTG I ++
Sbjct: 252 SENLP---PGSPVLQVTATDQDEGVNAEINYYFRSTAQSTKHMFSLDEKTGMIKNNQSFD 308
Query: 812 QTDYGLHRLLVKVSDHGYPEPLHSTVMVNLFVNDTVSNESYIESL 856
D + + V+ D G ++ L ND S E I SL
Sbjct: 309 FEDVERYTMEVEAKDGGGLSTQCKVIIEILDENDN-SPEIIITSL 352
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,400,456
Number of Sequences: 37866
Number of extensions: 1858329
Number of successful extensions: 11558
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 193
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 3963
Number of HSP's gapped (non-prelim): 1079
length of query: 951
length of database: 18,247,518
effective HSP length: 112
effective length of query: 839
effective length of database: 14,006,526
effective search space: 11751475314
effective search space used: 11751475314
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.