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Search of human proteins with 189571674
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189571674 cadherin-like 23 isoform 1 precursor [Homo
sapiens]
(3354 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens] 6640 0.0
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 1061 0.0
gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens] 967 0.0
gi|16933557 dachsous 1 precursor [Homo sapiens] 922 0.0
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 899 0.0
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 895 0.0
gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens] 869 0.0
gi|47059046 dachsous 2 isoform 1 [Homo sapiens] 738 0.0
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 444 e-124
gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo s... 413 e-114
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 395 e-109
gi|216548385 dachsous 2 isoform 2 [Homo sapiens] 360 2e-98
gi|16933559 protocadherin LKC precursor [Homo sapiens] 323 2e-87
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 305 4e-82
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 301 9e-81
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 290 1e-77
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 290 1e-77
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 290 1e-77
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 290 1e-77
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 290 1e-77
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 290 1e-77
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 290 1e-77
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 290 1e-77
gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapi... 290 1e-77
gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens] 285 4e-76
gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens] 285 4e-76
gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapi... 285 5e-76
gi|16933565 protocadherin 21 precursor [Homo sapiens] 281 8e-75
gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens] 265 4e-70
gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens] 265 4e-70
>gi|189571674 cadherin-like 23 isoform 1 precursor [Homo sapiens]
Length = 3354
Score = 6640 bits (17226), Expect = 0.0
Identities = 3354/3354 (100%), Positives = 3354/3354 (100%)
Query: 1 MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60
MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM
Sbjct: 1 MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60
Query: 61 DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI
Sbjct: 61 DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
Query: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
Query: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP
Sbjct: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
Query: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD
Sbjct: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
Query: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL
Sbjct: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
Query: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD
Sbjct: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
Query: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL
Sbjct: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG 540
TVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG
Sbjct: 481 TVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG 540
Query: 541 EETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI 600
EETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI
Sbjct: 541 EETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI 600
Query: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE
Sbjct: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
Query: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR 720
VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR
Sbjct: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFR 720
Query: 721 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 780
INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD
Sbjct: 721 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 780
Query: 781 APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAML 840
APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAML
Sbjct: 781 APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAML 840
Query: 841 DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL 900
DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL
Sbjct: 841 DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVL 900
Query: 901 EGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE 960
EGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE
Sbjct: 901 EGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE 960
Query: 961 YQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT 1020
YQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT
Sbjct: 961 YQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT 1020
Query: 1021 DNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGK 1080
DNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGK
Sbjct: 1021 DNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGK 1080
Query: 1081 RHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYR 1140
RHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYR
Sbjct: 1081 RHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYR 1140
Query: 1141 ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVED 1200
ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVED
Sbjct: 1141 ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVED 1200
Query: 1201 INDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDE 1260
INDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDE
Sbjct: 1201 INDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDE 1260
Query: 1261 STGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEA 1320
STGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEA
Sbjct: 1261 STGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEA 1320
Query: 1321 AILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE 1380
AILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE
Sbjct: 1321 AILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE 1380
Query: 1381 KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440
KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT
Sbjct: 1381 KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440
Query: 1441 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS 1500
VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS
Sbjct: 1441 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS 1500
Query: 1501 DRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGIN 1560
DRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGIN
Sbjct: 1501 DRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGIN 1560
Query: 1561 SVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHV 1620
SVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHV
Sbjct: 1561 SVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHV 1620
Query: 1621 YVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIV 1680
YVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIV
Sbjct: 1621 YVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIV 1680
Query: 1681 NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDN 1740
NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDN
Sbjct: 1681 NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDN 1740
Query: 1741 VPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGV 1800
VPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGV
Sbjct: 1741 VPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGV 1800
Query: 1801 LRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITI 1860
LRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITI
Sbjct: 1801 LRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITI 1860
Query: 1861 SENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP 1920
SENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP
Sbjct: 1861 SENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP 1920
Query: 1921 EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV 1980
EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV
Sbjct: 1921 EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV 1980
Query: 1981 LNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELL 2040
LNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELL
Sbjct: 1981 LNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELL 2040
Query: 2041 LLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGL 2100
LLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGL
Sbjct: 2041 LLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGL 2100
Query: 2101 NGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV 2160
NGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV
Sbjct: 2101 NGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV 2160
Query: 2161 TILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDT 2220
TILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDT
Sbjct: 2161 TILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDT 2220
Query: 2221 DRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLT 2280
DRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLT
Sbjct: 2221 DRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLT 2280
Query: 2281 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVP 2340
VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVP
Sbjct: 2281 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVP 2340
Query: 2341 PGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNP 2400
PGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNP
Sbjct: 2341 PGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNP 2400
Query: 2401 IFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVL 2460
IFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVL
Sbjct: 2401 IFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVL 2460
Query: 2461 SSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYE 2520
SSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYE
Sbjct: 2461 SSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYE 2520
Query: 2521 NEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLT 2580
NEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLT
Sbjct: 2521 NEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLT 2580
Query: 2581 VVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDK 2640
VVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDK
Sbjct: 2581 VVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDK 2640
Query: 2641 DEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 2700
DEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV
Sbjct: 2641 DEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 2700
Query: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP 2760
PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP
Sbjct: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP 2760
Query: 2761 NAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPT 2820
NAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPT
Sbjct: 2761 NAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPT 2820
Query: 2821 LDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSL 2880
LDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSL
Sbjct: 2821 LDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSL 2880
Query: 2881 VFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGH 2940
VFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGH
Sbjct: 2881 VFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGH 2940
Query: 2941 NDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKG 3000
NDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKG
Sbjct: 2941 NDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKG 3000
Query: 3001 RVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRLPD 3060
RVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRLPD
Sbjct: 3001 RVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNYNVLDVQPAISVRLPD 3060
Query: 3061 DMSALQMAIIVLAILLFLAAMLFVLMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNT 3120
DMSALQMAIIVLAILLFLAAMLFVLMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNT
Sbjct: 3061 DMSALQMAIIVLAILLFLAAMLFVLMNWYYRTVHKRKLKAIVAGSAGNRGFIDIMDMPNT 3120
Query: 3121 NKYSFDGANPVWLDPFCRNLELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAV 3180
NKYSFDGANPVWLDPFCRNLELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAV
Sbjct: 3121 NKYSFDGANPVWLDPFCRNLELAAQAEHEDDLPENLSEIADLWNSPTRTHGTFGREPAAV 3180
Query: 3181 KPDDDRYLRAAIQEYDNIAKLGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSC 3240
KPDDDRYLRAAIQEYDNIAKLGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSC
Sbjct: 3181 KPDDDRYLRAAIQEYDNIAKLGQIIREGPIKGSLLKVVLEDYLRLKKLFAQRMVQKASSC 3240
Query: 3241 HSSISELIQTELDEEPGDHSPGQGSLRFRHKPPVELKGPDGIHVVHGSTGTLLATDLNSL 3300
HSSISELIQTELDEEPGDHSPGQGSLRFRHKPPVELKGPDGIHVVHGSTGTLLATDLNSL
Sbjct: 3241 HSSISELIQTELDEEPGDHSPGQGSLRFRHKPPVELKGPDGIHVVHGSTGTLLATDLNSL 3300
Query: 3301 PEEDQKGLGRSLETLTAAEATAFERNARTESAKSTPLHKLRDVIMETPLEITEL 3354
PEEDQKGLGRSLETLTAAEATAFERNARTESAKSTPLHKLRDVIMETPLEITEL
Sbjct: 3301 PEEDQKGLGRSLETLTAAEATAFERNARTESAKSTPLHKLRDVIMETPLEITEL 3354
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 1061 bits (2745), Expect = 0.0
Identities = 880/2873 (30%), Positives = 1352/2873 (47%), Gaps = 195/2873 (6%)
Query: 73 EASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTF 132
E+ FA+ TG ++ +DRE+ + V +V + V D+NDNAP F
Sbjct: 76 ESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVF 135
Query: 133 HNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ----PPSQFFAID-----SA 183
+ V E++ G + + ATD D+G+ G S++ + F +D S
Sbjct: 136 PDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSG 195
Query: 184 RGIVTVIRE---LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
G + LD E T YQL V D+ + + L + + + D+ D P+F +
Sbjct: 196 EGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYL-QVNVTVQDINDNPPVFGSSH 254
Query: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
Y + E + G++V + A D D+G I Y + T F +D +G++T+ LD
Sbjct: 255 YQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTP--FQMDPETGLITVREPLD 312
Query: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAP-----EFNSSEYSV 355
E + LTV+ DR T I ++D+NDN P F ++
Sbjct: 313 FE---ARRQYSLTVQAM----DRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYA 365
Query: 356 AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRV 415
++ E AQVG + L + V D D ++ L GN HF + + V + I+V
Sbjct: 366 SVDENAQVGTVVAL-LTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLS--LIKV 422
Query: 416 AIPLDYETVDRYDFDLFANE--------SVPDHVGYAKVKITLINENDNRPIFSQPLYNI 467
A LD E + Y+ + ++ +V A + I + + ND+ P+FSQ +Y +
Sbjct: 423 ASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRV 482
Query: 468 SLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRFSLDKDTGLIML--IARLDY 523
+L E G+ V + ATD D+G + Y + F + + +GL+ LD
Sbjct: 483 NLSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDR 542
Query: 524 ELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNVPTF-QKDAYVGALRENEPSVTQL 580
EL + L I ARD G + + ++ + +LDVND P F Q + Y ++ EN P+ T+L
Sbjct: 543 ELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTEL 602
Query: 581 VRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 640
+ LRATD D N + +S+ A F + G +S LD E+ L
Sbjct: 603 LMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGR--LSTISSLDREE--QAFYSLL 658
Query: 641 VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR 700
V+A D G+PP +S + + + D NDN P F YF + EN G+ + ++ATD D
Sbjct: 659 VLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDL 718
Query: 701 SREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTG 760
G S ++F++NA+SG I+T LDRE K+ Y L + A DG G+ Q
Sbjct: 719 GTN-GTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDG--GNLQSPN 775
Query: 761 IATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP 820
A V IT+LD DN P + Y + E V +V A DL N + + +
Sbjct: 776 QAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNISYLITTGDQ 835
Query: 821 NKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNL 880
+++N TG++ TT ++DRE ++ K+V S T V + +
Sbjct: 836 KGMFAINQVTGQL-TTANVIDREEQSFYQL----KVVASGG-------TVTGDTMVNITV 883
Query: 881 LDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLI 940
DLNDN P F V+E AG SI+Q A+D DEG+NG+V Y + P+ F I
Sbjct: 884 KDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQN-PKNLFAI 942
Query: 941 NSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVY 1000
N +G + LD YQ+ ++ASD G P SS+ LT++V DVND +P F Y
Sbjct: 943 NEKNGTISLLGPLD-VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSY 1001
Query: 1001 NVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDR 1060
V++SE P R + +D D G N E++Y I GN F + + D + LDR
Sbjct: 1002 EVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGI-FPDGQLYIKSELDR 1060
Query: 1061 ETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL--DVNDNRPIFLQSSYEASVPEDIPEG 1118
E Y+L++ A D +ATV VTV+ DVNDNRP+F ++Y E+ G
Sbjct: 1061 ELQDRYVLMVVASDRAV----EPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAG 1116
Query: 1119 HSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRE----RNSSH 1174
+ ++ A D D G G V Y +F +H +G + DRE R +
Sbjct: 1117 SFVGKVSAVDKDFGPNGEVRYSFEMVQ--PDFELHAISGEI-TNTHQFDRESLMRRRGTA 1173
Query: 1175 VLIVEAYNHDLG---PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVV 1231
V D G P++ V VY++DIND AP F + Y + + E+A T V+ V
Sbjct: 1174 VFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFY-QATISESAANLTQVLRV 1232
Query: 1232 QATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAP 1290
A+D D G+ GL++Y I+ G E +F ID ++G + + LDYE +Y + + A D
Sbjct: 1233 SASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGT 1292
Query: 1291 PFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRF 1350
C++ I +L+E D F ++ +LEN+ +G + V A D+ + +
Sbjct: 1293 IPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADL-Y 1351
Query: 1351 NAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVL 1409
+ T T F I TG I + +D E Y L + A D G P ST+ V I V
Sbjct: 1352 YSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVR 1411
Query: 1410 DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI 1469
D NDN P F D SI E+ P+G V +V A DPDA NGQ+ +++ G
Sbjct: 1412 DFNDNPPSFP-PGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRG--NH 1468
Query: 1470 VTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQ-VTIL--DINDNPPV 1526
T ++ G ++ +DRE + + L V A+D+ P + + L+ VTIL D+NDN P+
Sbjct: 1469 FTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPM 1528
Query: 1527 IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIA 1586
S ++ + + G+ + + A D D G N + Y I G+ D F +DR SG++
Sbjct: 1529 FISQNA--LAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTD-TFIVDRYSGDL- 1584
Query: 1587 TRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEG 1646
R A Q Y+L+ + D G +TT +TI+ + + P+F QP Y +L EG
Sbjct: 1585 -RVASALVPSQLIYNLIVSATDLGPERRKSTTE--LTIILQGLDGPVFTQPKYITILKEG 1641
Query: 1647 PDTLNTSLITIQALDLDEGPNGTVTYAIVA-----GNIVNTFRIDRHMGVITAAKELDYE 1701
+ + T++I+I+A G V Y IV+ + F I RH G+I A LD E
Sbjct: 1642 -EPIGTNVISIEAAS-PRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDRE 1699
Query: 1702 ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGP 1761
Y + V A ++ T V + + DINDN P FP D G
Sbjct: 1700 QGACLYLVDVYAIEKSTAFPR--TQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGS 1757
Query: 1762 RVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTI 1821
++ A D D G N V Y+I+ G F I P G L + LDRE + Y+L +
Sbjct: 1758 KIMQLTAMDADEGANALVTYTIISGAD-DSFRIDPESGDLIATR--RLDRERRSKYSLLV 1814
Query: 1822 CARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSG 1881
A D G+ SS M + I V D+ND+ P + I E++ S VA +LA+D DSG
Sbjct: 1815 RA-DDGLQ--SSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSG 1871
Query: 1882 CNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRD 1941
N +T+ + + + FF+N TG+ + R LD E Y LT+ +D R
Sbjct: 1872 VNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGGQFTTIRVY 1931
Query: 1942 YDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQ 2001
+++L D NDN P+F+ ++Y +MEN P G+ + V N DAD I + +TY
Sbjct: 1932 FNIL-----DVNDNPPIFSLNSYSTSLMENLPVGSTVLVFN----VTDADDGINSQLTYS 1982
Query: 2002 LLGAQS-GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE-DIGLLNSTAHLLITI 2059
+ S G F ++ + GV+ V + + ++F ++++ L + STA + I +
Sbjct: 1983 IASGDSLGQFTVDKN-GVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIIL 2041
Query: 2060 LDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIH 2119
LD NDN PTF LT ++ EN P V + ATD DSG N + Y + ++F I
Sbjct: 2042 LDVNDNPPTFLSPKLT-YIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIG 2100
Query: 2120 LVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
+ G +R+ +DREE +Y LTVVATD+G LS + V +++ DIND+ P F +
Sbjct: 2101 TIDGEVRL-TGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALY 2159
Query: 2180 TVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINT 2237
V + E+ GT I + A D D N ++ Y IV N F ++ T
Sbjct: 2160 KVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVN-----------GNTNQEFRIDSVT 2208
Query: 2238 GSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFG 2297
G++ V P++RE TY +T+ D S P S +++ +LD+ND P F+
Sbjct: 2209 GAITVAKPLDREKTPTYHLTVQATDRGS-TPRTDTST----VSIVLLDINDFVPVFE--- 2260
Query: 2298 ITYYMERILEG-ATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIA 2356
++ Y + E T T++ V A D D+G N ++Y L L S++G++
Sbjct: 2261 LSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTL--SASGELGV 2318
Query: 2357 NRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVP 2416
+++D E + A+D+GSP + + + D+NDN P F +Y + ED P
Sbjct: 2319 TQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAP 2378
Query: 2417 VGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTAL 2476
GT +L V A+DAD+ A+I + G S+F INP+TG I + LDRE KD+Y L +
Sbjct: 2379 TGTDVLLVNASDADASKNAVIR--IIGGNSQFTINPSTGQIITSALLDRETKDNYTLVVV 2436
Query: 2477 AKD--NPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMAT 2534
D +P ++S S V++ V DVND P+F + T + G+ V + T
Sbjct: 2437 CSDAGSPEPLSS-----STSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVT 2491
Query: 2535 DQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGT 2594
D D GPN EL YSL G E FH+D G + PL + + +V DGG P +
Sbjct: 2492 DADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHVKDGGSFPKTDS 2551
Query: 2595 TMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLK 2654
T + V ++ D VR T + P V + T L G S+
Sbjct: 2552 TTVTVRFVNKADFPK--VRAKEQTFM-----FPENQPVSSLVTTITGSSLRGE-PMSYYI 2603
Query: 2655 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALED 2714
+GN F ID ++G + +Q LD E Y + + A D G P P+ + + L + + D
Sbjct: 2604 ASGNLG-NTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP-PFSSYEKLDITVLD 2661
Query: 2715 IDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEE 2774
++DN P+F P S + L SPR L A+D D GPN + Y I GN E
Sbjct: 2662 VNDNAPIFKEDPFISEILENL-----SPRKIL---TVSAMDKDSGPNGQLDYEIVNGNME 2713
Query: 2775 KNFHL-QPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVR 2833
+F + G + +R LDRE+ + + +K+S S PS + T +V
Sbjct: 2714 NSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGS------PSQS-------TSVKVM 2760
Query: 2834 VVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
+ + D ND PRF++ ++A V ++ +G + +V D DIG N++ YSI+
Sbjct: 2761 INILDENDNAPRFSQI-FSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIM 2812
Score = 1024 bits (2648), Expect = 0.0
Identities = 894/2943 (30%), Positives = 1374/2943 (46%), Gaps = 227/2943 (7%)
Query: 39 YLLISEDTPVGSSVTQLLAQDMD----NDPLVFGVSGEEASRFFAVE----PDTGVVWLR 90
Y + E+ VG+ V L D D N + + G R F V+ P+ ++ +
Sbjct: 364 YASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVA 423
Query: 91 QPLDRETKSEFTVEFSVSDHQGV----------ITRKVNIQVGDVNDNAPTFHNQPYSVR 140
LDRE + + SVSD+ G + I V D+ND+ P F Q Y V
Sbjct: 424 SALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVN 483
Query: 141 IPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRE--LDYE 196
+ E P G+ + ++ATD D G ++ YS + +F I G+VT LD E
Sbjct: 484 LSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE 543
Query: 197 TTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP-YSTNIYEHSPPGTTV 255
L ++A DQ P + A L + + DV D P+F Y ++ E++P GT +
Sbjct: 544 LASQIVLNISARDQG-VHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTEL 602
Query: 256 RIITAIDQDKGRPRGIGYTIVSGNTNS-IFALDYISGVLTLNGLLDRENPLYSHGFILTV 314
++ A D D G + +++ T+ F LD +SG L+ LDRE + + L V
Sbjct: 603 LMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAF---YSLLV 659
Query: 315 KGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVV 374
T+L S A + N+ ++DINDN+P F +Y I E G + V
Sbjct: 660 LATDLGSPPQSSMARI----NVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITT---VS 712
Query: 375 DKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFAN 434
D +LG N + + + F ++ S I R+A LD E Y + A
Sbjct: 713 ATDPDLGTNGTVKYSISAGDRSRFQVNAQS----GVISTRMA--LDREEKTAYQLQIVAT 766
Query: 435 ESVP-DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFG 493
+ A V IT+++ DN P+FSQ Y+ ++ENV +G V +V A+ D +
Sbjct: 767 DGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNS-- 824
Query: 494 EVSYFFS--DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINV 551
+SY + D F++++ TG + +D E + L ++A GG V I V
Sbjct: 825 NISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA-SGGTVTGDTMVNITV 883
Query: 552 LDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFD 611
D+NDN P F + + EN + + + +A D D N + YS+ + F
Sbjct: 884 KDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPK--NLFA 941
Query: 612 ISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTF 671
I+ E G IS+ PLD + G + ++A D G P L+S+V +T+ V D NDN P F
Sbjct: 942 IN--EKNGTISLLGPLD---VHAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVF 996
Query: 672 SKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQFRINA-RSGEIT 729
+ +Y V++ E+ + + A+D D I Y++ EG+T G++
Sbjct: 997 DQLSYEVTLSESEPVNSRFFKVQASDKDSG---ANGEIAYTIAEGNTGDAFGIFPDGQLY 1053
Query: 730 TTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLL--DINDNHPTWKDAPYYINL 787
S LDRE + Y+L+V A D V + ATVN+T++ D+NDN P + Y
Sbjct: 1054 IKSELDRELQDRYVLMVVASDRAV----EPLSATVNVTVILEDVNDNRPLFNSTNYTFYF 1109
Query: 788 VEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDP 847
E S V V AVD D G NG + YS + + L++ +G+I TH DRE+
Sbjct: 1110 EEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTH-QFDRESLMR 1168
Query: 848 HEAELMRKIVVSVTDCGRP-PLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAG 906
+ V TD G P PLK ATV V + D+NDN P F + A + E
Sbjct: 1169 RRGTAVFSFTVIATDQGIPQPLK--DQATVHVYMKDINDNAPKFLKDFYQATISESAANL 1226
Query: 907 VSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVV 966
+ +V A D+DEG NGL+ Y + G F I+S+SG V +LD E Y L +
Sbjct: 1227 TQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQ 1286
Query: 967 ASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGL 1026
A D+GT +ST TL I +LD ND TP+F + V V E++ V + TD+D G
Sbjct: 1287 AVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGD 1346
Query: 1027 NAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTA 1086
NA+L Y ITG N G FS+ + LD ET + Y L + A D G + + T
Sbjct: 1347 NADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPR--SSTM 1404
Query: 1087 TVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG-N 1145
+V + V D NDN P F S+ E+IP G S++ + A D D G++ Y I+
Sbjct: 1405 SVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMP 1464
Query: 1146 HGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSS----VRVIVYVEDI 1201
GN+F I G + +DRE + L V+A N P+ + V + V D+
Sbjct: 1465 RGNHFTIDEVKGTIYTNAE-IDREFANLFELTVKA-NDQAVPIETRRYALKNVTILVTDL 1522
Query: 1202 NDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDES 1261
ND P+F Q + L +A IG+ + + A D D G G + Y I++G F +D
Sbjct: 1523 NDNVPMFISQ--NALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDTFIVDRY 1580
Query: 1262 TGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAA 1321
+G + + L ++ Y + VSATD P + + I +L LD V F+ Y
Sbjct: 1581 SGDLRVASAL-VPSQLIYNLIVSATDLGPERRKSTTELTI-ILQGLDGPV-FTQPKYITI 1637
Query: 1322 ILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKA---LFKIDAITGVITVQGLVD 1378
+ E +GT ++ ++A S + + K LF I TG+I ++D
Sbjct: 1638 LKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILD 1697
Query: 1379 REKGD-FYTLTVVADDGGPKVDST--VKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVG 1435
RE+G Y + V A + T +V IT+ D NDN P F T +++ E+ G
Sbjct: 1698 REQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFP-TDMLDLTVEENIGDG 1756
Query: 1436 QRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYIL 1495
++ + A D D G+N V +++ I+GA + + G++ R LDRE Y L
Sbjct: 1757 SKIMQLTAMDADEGANALVTYTI----ISGADDSFRIDPESGDLIATRRLDRERRSKYSL 1812
Query: 1496 QVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1555
V A D + D + +T+ D+ND+ P P Y+ + E+ G+ V + ATD
Sbjct: 1813 LVRADD---GLQSSDMRINITVSDVNDHTPKFSRPV-YSFDIPEDTIPGSLVAAILATDD 1868
Query: 1556 DIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLS 1615
D G+N ++Y + E ++D F ++ I+G + D E Q +Y L ED G
Sbjct: 1869 DSGVNGEITYIVNEDDEDGIFFLNPITG-VFNLTRLLDYEVQQYYILTVRAEDGGGQ--F 1925
Query: 1616 ATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIV 1675
T VY I+D NDN P+F Y L E +T L+ D D+G N +TY+I
Sbjct: 1926 TTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLV-FNVTDADDGINSQLTYSIA 1984
Query: 1676 AGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVN 1735
+G+ + F +D++ GV+ K LD E S Y L+V D I + R TST V + +
Sbjct: 1985 SGDSLGQFTVDKN-GVLKVLKALDRE-SQSFYNLVVQVHDLPQIPASRFTSTAQVSIILL 2042
Query: 1736 DINDNVPTF--PRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLG-E 1791
D+NDN PTF P+ + E P V+ A D DSGPN +EY+++ +PLG +
Sbjct: 2043 DVNDNPPTFLSPK----LTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLL--NPLGNK 2096
Query: 1792 FVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVL 1851
F I ++G VR ELDRE ++ Y LT+ A D+G P LSS+ V + VLDINDN+P+
Sbjct: 2097 FSIGTIDG--EVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIF 2154
Query: 1852 LNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVN 1911
+ I+EN+ + + V A+D D G N ++ + I GN + F I++ TG +TV
Sbjct: 2155 AQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVA 2214
Query: 1912 RPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMEN 1971
+PLDRE+ P Y LT+ D P R D + I L D ND P+F S Y V EN
Sbjct: 2215 KPLDREKTPTYHLTVQATDRGSTP---RTDTSTVSIVLLDINDFVPVFELSPYSVNVPEN 2271
Query: 1972 SPAGT-PLTVLNGPILALDADQDIYAVVTYQLLGA-QSGLFDINSSTGVVTVRSGVIIDR 2029
GT P T+L ++A D D+ + ++Y L G + F +++S + +S +DR
Sbjct: 2272 --LGTLPRTILQ--VVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQS---LDR 2324
Query: 2030 EAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVL 2089
E +L + L T + + + D NDN PTF+ + E+ P G VL
Sbjct: 2325 ETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVL 2384
Query: 2090 QVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDR 2149
V A+D D+ N V RI G +F I+ TG I + +A +DRE +++Y L VV +D
Sbjct: 2385 LVNASDADASKNA--VIRI-IGGNSQFTINPSTGQI-ITSALLDRETKDNYTLVVVCSDA 2440
Query: 2150 GT-VPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLE 2208
G+ PLS + V + + D+ND+ P F + + PG+ + +T D D+ P E
Sbjct: 2441 GSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSE 2500
Query: 2209 YHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSV-IDNASDL 2267
H L + F ++ G++M P+N EVT SV + +
Sbjct: 2501 LHY----------SLSGRNSEKFHIDPLRGAIMAAGPLN----GASEVTFSVHVKDGGSF 2546
Query: 2268 PERSVSVPNAKLTVNVLDVND-NTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKG 2326
P+ TV V VN + P+ + T+ ++ TT+
Sbjct: 2547 PKTD------STTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITG-------SS 2593
Query: 2327 LNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEI 2386
L G + G D G+V ++ +D+E++ + A D G PP ++
Sbjct: 2594 LRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYE 2653
Query: 2387 PVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDG 2444
+ + ++D+NDN PIF + + + E++ ILTV+A D DSG ++Y + G+
Sbjct: 2654 KLDITVLDVNDNAPIFKEDPFISEILENLSPRK-ILTVSAMDKDSGPNGQLDYEIVNGNM 2712
Query: 2445 ESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVND 2504
E+ F+IN TG+I + LDREK HY+LT + D S + SV+V+I +LD ND
Sbjct: 2713 ENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDK----GSPSQSTSVKVMINILDEND 2768
Query: 2505 CRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGL 2564
P+FS+ FS V EN P G +V + +D+D G N YS+ + F ++ +G
Sbjct: 2769 NAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASL-PFTINPSTGD 2826
Query: 2565 VTTQRPL--QSYEKFSLTVVATDGGEPPLWG-TTMLLVEVIDVNDNRPVFVRPPNGTILH 2621
+ RPL + +++ + V A D G W +T + + V D+NDN P F R L
Sbjct: 2827 IVISRPLNREDTDRYRIRVSAHDSG----WTVSTDVTIFVTDINDNAPRFSR--TSYYLD 2880
Query: 2622 IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDR 2681
E + S V +V+ATD DEG NG V Y F+K+ E+F I+ +G I Q L
Sbjct: 2881 CPELTEIGSKVTQVFATDPDEGSNGQVFY-FIKSQS----EYFRINATTGEIFNKQILKY 2935
Query: 2682 ESQAVY--------SLILVASDLGQP-VPYETMQPLQVALEDIDDNEPLFVRPPKGSPQY 2732
++ + S I+ +SD G+P + ET + + D +DN P F++ +P
Sbjct: 2936 QNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV--DSNDNAPQFLKSKYFTP-- 2991
Query: 2733 QLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDL 2791
V ++ GT + VT D D G N+ V YFI+ N F L D G + V L
Sbjct: 2992 ----VTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSL 3047
Query: 2792 DREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEY 2851
+ +F + ++ PP T V + + + N P F+++
Sbjct: 3048 ISDLNQ--NFFITVTAKDKGNPPLSSQAT-----------VHITVTEENYHTPEFSQSHM 3094
Query: 2852 TAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMD 2911
+A + +GS + V A D D N L+ YSI S + +F + S
Sbjct: 3095 SATIPESHSIGSIVRTVSARDRDAAMNGLIKYSI-----------SSGNEEGIFAINSST 3143
Query: 2912 GIL 2914
GIL
Sbjct: 3144 GIL 3146
Score = 1020 bits (2638), Expect = 0.0
Identities = 883/2908 (30%), Positives = 1371/2908 (47%), Gaps = 222/2908 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQP--LDRE 96
+SE+ P GS V+ + A D D N L + + +F + +G+V LDRE
Sbjct: 484 LSEEAPPGSYVSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE 543
Query: 97 TKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQP--YSVRIPENTPVGTPI 151
S+ + S D H V ++ + + DVND P F +QP Y V + EN P GT +
Sbjct: 544 LASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDEKPVF-SQPEGYDVSVVENAPTGTEL 602
Query: 152 FIVNATDPDLGAGGSVLYSFQPPS---QFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
++ ATD DLG G+V +S Q + F +D G ++ I LD E Y L V AT
Sbjct: 603 LMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLAT 662
Query: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
D P S++A + + + D+ D P+F + Y +I E+ P G+ + ++A D D G
Sbjct: 663 DLGSP-PQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTN 721
Query: 269 RGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDA 328
+ Y+I +G+ S F ++ SGV++ LDRE + L + T+ + ++P+ A
Sbjct: 722 GTVKYSISAGD-RSRFQVNAQSGVISTRMALDREEKT---AYQLQIVATDGGNLQSPNQA 777
Query: 329 TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-PLFIQVVDKDENLGLNSMFE 387
VT T V+D DN P F+ YS + E +G+ + + +D + N+
Sbjct: 778 IVTIT----VLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNIS------ 827
Query: 388 VYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVK 447
YL+ + + V G+ + A +D E Y + A+ G V
Sbjct: 828 -YLITTGDQKGMFAINQVTGQ----LTTANVIDREEQSFYQLKVVASGGTV--TGDTMVN 880
Query: 448 ITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR-F 506
IT+ + NDN P F Q + ++++ EN G S+ A D D G G V Y +P F
Sbjct: 881 ITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLF 940
Query: 507 SLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVL--DVNDNVPTFQKD 564
++++ G I L+ LD + + I+A D G + + V + V DVNDN P F +
Sbjct: 941 AINEKNGTISLLGPLDVHA-GSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQL 999
Query: 565 AYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS---AFGSYFDISLYEGYGVI 621
+Y L E+EP ++ +++A+D+DS N +I Y+I + AFG + D LY
Sbjct: 1000 SYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLY------ 1053
Query: 622 SVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVV 681
+ LD E + L V+A D PL++TV VT+ + D NDN P F+ Y
Sbjct: 1054 -IKSELDRELQDRYV--LMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFE 1110
Query: 682 ENIMAGATVLFLNATDLDRSREYGQESII-YSLEG-STQFRINARSGEITTTSLLDRET- 738
E AG+ V ++A D D +G + YS E F ++A SGEIT T DRE+
Sbjct: 1111 EEQRAGSFVGKVSAVDKD----FGPNGEVRYSFEMVQPDFELHAISGEITNTHQFDRESL 1166
Query: 739 -----KSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793
+ + V A D G+ K ATV++ + DINDN P + Y + E
Sbjct: 1167 MRRRGTAVFSFTVIATDQGIPQPLKDQ-ATVHVYMKDINDNAPKFLKDFYQATISESAAN 1225
Query: 794 DSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851
+ V V A D D G NG + YSI N + ++++ST+G++ T LD +EA
Sbjct: 1226 LTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQV-TLIGKLD------YEAT 1278
Query: 852 LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQ 911
+V+ D G PL +T T+ +++LD NDN P+F +VLE + G +
Sbjct: 1279 PAYSLVIQAVDSGTIPLNST--CTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSS 1336
Query: 912 VVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG 971
V A D D G N + Y + F I+ ++G + +LD E + Y+L + A D G
Sbjct: 1337 VTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQG 1396
Query: 972 TPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELS 1031
P +SST ++ IHV D ND P+F P S+ E++P V+ + D D +N +LS
Sbjct: 1397 RPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLS 1456
Query: 1032 YFITGGNVDGK-FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVF 1089
Y I G F++ + T +DRE + L ++A D P+ R V
Sbjct: 1457 YTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVT 1516
Query: 1090 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNN 1149
+ V D+NDN P+F+ + A+ P + G + + A D DEG G + Y I++G+ +
Sbjct: 1517 ILVTDLNDNVPMFISQNALAADPSAVI-GSVLTTIMAADPDEGANGEIEYEIINGDT-DT 1574
Query: 1150 FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMR--SSVRVIVYVEDINDEAPV 1207
F + +G L + + + LIV A DLGP R S+ + + ++ + + PV
Sbjct: 1575 FIVDRYSGDLRVASALVPSQL--IYNLIVSAT--DLGPERRKSTTELTIILQGL--DGPV 1628
Query: 1208 FTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK-----FEIDEST 1262
FTQ +Y + L+E IGT+VI ++A + + Y + E K F I T
Sbjct: 1629 FTQPKYITI-LKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHT 1687
Query: 1263 GLIITVNYLDYETKTS-YMMNVSATDQAPPFNQGF-CSVYITLLNELDEAVQFSNASYEA 1320
G+I T LD E Y+++V A +++ F + V ITL + D F +
Sbjct: 1688 GIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDL 1747
Query: 1321 AILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE 1380
+ EN+ G++I+++ A D + + A F+ID +G + +DRE
Sbjct: 1748 TVEENIGDGSKIMQLTAMDADEGANALVTYTIISG--ADDSFRIDPESGDLIATRRLDRE 1805
Query: 1381 KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440
+ Y+L V ADDG D +++ ITV D ND++P+F S IPED G VA
Sbjct: 1806 RRSKYSLLVRADDGLQSSD--MRINITVSDVNDHTPKFSRPVYS-FDIPEDTIPGSLVAA 1862
Query: 1441 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS 1500
+ A D D+G NG++ + + + G F + N G + R LD E +YIL V A
Sbjct: 1863 ILATDDDSGVNGEITYIVNEDDEDGIFFL---NPITGVFNLTRLLDYEVQQYYILTVRAE 1919
Query: 1501 DRG---TPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDI 1557
D G T R + ILD+NDNPP+ S Y+ S+ EN+ G+ V+ TD D
Sbjct: 1920 DGGGQFTTIR-----VYFNILDVNDNPPIF-SLNSYSTSLMENLPVGSTVLVFNVTDADD 1973
Query: 1558 GINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEG---TPTL 1614
GINS L+Y I G+ F +D+ +G + A DRE QSFY+LV V D
Sbjct: 1974 GINSQLTYSIASGDSLGQFTVDK-NGVLKVLKAL-DRESQSFYNLVVQVHDLPQIPASRF 2031
Query: 1615 SATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAI 1674
++T V + ++D NDN P F P + + P ++T + QA D D GPN + Y +
Sbjct: 2032 TSTAQVSIILLDVNDNPPTFLSPKLTYIPENTP--IDTVVFKAQATDPDSGPNSYIEYTL 2089
Query: 1675 VAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNV 1734
+ + N F I G + ELD E YTL V ATD+ L+S+T V+V V
Sbjct: 2090 L-NPLGNKFSIGTIDGEVRLTGELDRE-EVSNYTLTVVATDKG---QPSLSSSTEVVVMV 2144
Query: 1735 NDINDNVPTFPRDYEGPFEVTEGQ-PGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFV 1793
DINDN P F + E+ E G + A D D G NGQV Y I++G+ EF
Sbjct: 2145 LDINDNNPIFAQALY-KVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFR 2203
Query: 1794 ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLN 1853
I V G + V K LDRE Y+LT+ A DRG P + T V I +LDIND PV
Sbjct: 2204 IDSVTGAITVAKP--LDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFEL 2261
Query: 1854 LPMNITISEN-SPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNR 1912
P ++ + EN + + V+A D D G N++L++ + GN + AF ++A+ G + V +
Sbjct: 2262 SPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSAS-GELGVTQ 2320
Query: 1913 PLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENS 1972
LDRE + L I+ D+ A + + + D NDN P F Y + E++
Sbjct: 2321 SLDRETKERFVLMITATDSGSP---ALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDA 2377
Query: 1973 PAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAF 2032
P GT + ++N A DAD AV+ +++G S F IN STG + + ++DRE
Sbjct: 2378 PTGTDVLLVN----ASDADASKNAVI--RIIGGNSQ-FTINPSTGQII--TSALLDRE-- 2426
Query: 2033 SPPILELLLLAEDIGL---LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVL 2089
+ L+++ D G L+S+ +L+T+ D NDN P F H+ PG V
Sbjct: 2427 TKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVF 2486
Query: 2090 QVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDR 2149
VT TD D G N EL Y + ++F I + G I E +V D
Sbjct: 2487 AVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASE---VTFSVHVKDG 2543
Query: 2150 GTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEY 2209
G+ P + + VT+ + D P+ QT E+ +++ IT P Y
Sbjct: 2544 GSFPKTDSTTVTVRFVNKADF-PKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEPMSYY 2602
Query: 2210 HIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPE 2269
G N + F ++ TG V + P++ E + Y V + D P
Sbjct: 2603 IASG------------NLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFP-PF 2649
Query: 2270 RSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNG 2329
S KL + VLDVNDN P FK ++ ILE +P ++ V+A+D D G NG
Sbjct: 2650 SSYE----KLDITVLDVNDNAPIFKE---DPFISEILENLSP-RKILTVSAMDKDSGPNG 2701
Query: 2330 LVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVY 2389
+ Y +++ + ++ G++ + R +D E+V T+++SD GSP ++ + V
Sbjct: 2702 QLDYEIVNGNMENSFSINHAT-GEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVM 2760
Query: 2390 LEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFA 2449
+ I+D NDN P F Q + V E+ P+G + VT +D D G A+ YS+ D F
Sbjct: 2761 INILDENDNAPRFSQ-IFSAHVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLPFT 2819
Query: 2450 INPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF 2509
INP+TGDI + L+RE D Y + A D+ V S V I V D+ND P+F
Sbjct: 2820 INPSTGDIVISRPLNREDTDRYRIRVSAHDSGWTV-------STDVTIFVTDINDNAPRF 2872
Query: 2510 SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQR 2569
S+ + E G+ V + ATD DEG NG++ Y ++ E F ++ +G + ++
Sbjct: 2873 SRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQS-EYFRINATTGEIFNKQ 2931
Query: 2570 PLQ----------SYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI 2619
L+ + + S V ++D G+P L T + + ++D NDN P F++ T
Sbjct: 2932 ILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFT- 2990
Query: 2620 LHIREEIPLRSNVYEVYATD-KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ + + + + + V A D KD GLN V Y + + F +D +G I A
Sbjct: 2991 -PVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFI---SNDNHLGKFKLDNDTGWISVASS 3046
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
L + + + + A D G P P + + + + + + + P F S + T+P
Sbjct: 3047 LISDLNQNFFITVTAKDKGNP-PLSSQATVHITVTEENYHTPEF------SQSHMSATIP 3099
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREA 2797
E G++V V+ A D D N ++ Y I++GNEE F + G L + + LD E
Sbjct: 3100 ESHSIGSIVRTVS-ARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQ 3158
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
+ A W VA V V + D+ND P F +Y V
Sbjct: 3159 KHEMTISAIDG-GW------------VARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLE 3205
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSI 2885
+A G+ +I + A DAD G N+++ Y++
Sbjct: 3206 NAPSGTTVIHLNATDADSGTNAVIAYTV 3233
Score = 1020 bits (2637), Expect = 0.0
Identities = 889/2903 (30%), Positives = 1338/2903 (46%), Gaps = 225/2903 (7%)
Query: 69 VSGEEASRF---FAVEPDTGVVWL----RQPLDRETKSEFTVEFSVSDHQGVITR---KV 118
+ G EA RF + P +L + LDRE ++ + V D R +V
Sbjct: 177 IRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQV 236
Query: 119 NIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFF 178
N+ V D+NDN P F + Y +PE+ VG+ + V A D D G + Y Q F
Sbjct: 237 NVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPF 296
Query: 179 AIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPI--F 236
+D G++TV LD+E + Y LTV A D+ L+ A I + DV D DP+ F
Sbjct: 297 QMDPETGLITVREPLDFEARRQYSLTVQAMDRG-VPSLTGRAEALIQLLDVNDNDPVVKF 355
Query: 237 INLPYST---NIYEHSPPGTTVRIITAIDQDKGRPRG-IGYTIVSGNTNSIFALDYIS-- 290
P ++ ++ E++ GT V ++T D D G I I+ GN F +
Sbjct: 356 RYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVP 415
Query: 291 --GVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDA----TVTTTFNILVIDIND 343
++ + LDRE P Y+ LTV ++ N P A + + I V DIND
Sbjct: 416 NLSLIKVASALDRERIPSYN----LTVSVSD-NYGAPPGAAVQARSSVASLVIFVNDIND 470
Query: 344 NAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN------SHH 397
+ P F+ Y V ++E A G + I D D L N + + + GN S H
Sbjct: 471 HPPVFSQQVYRVNLSEEAPPG-SYVSGISATDGDSGLNANLRYSI-VSGNGLGWFHISEH 528
Query: 398 FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNR 457
+ T G D + I L+ D + V V YA++ +TL++ ND +
Sbjct: 529 SGLVTTGSSGGLDRELASQIVLNISARD---------QGVHPKVSYAQLVVTLLDVNDEK 579
Query: 458 PIFSQPL-YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD---DPDRFSLDKDTG 513
P+FSQP Y++S+ EN GT +L + ATD D G G V + + D F LD +G
Sbjct: 580 PVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSG 639
Query: 514 LIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINV--LDVNDNVPTFQKDAYVGALR 571
+ I+ LD E ++L ++A D G + RINV LD+NDN P F Y ++
Sbjct: 640 RLSTISSLDREEQAFYSLLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIK 699
Query: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ 631
ENEP + + + ATD D N + YSI + S F ++ GVIS LD E+
Sbjct: 700 ENEPGGSYITTVSATDPDLGTNGTVKYSISAGDR--SRFQVNAQS--GVISTRMALDREE 755
Query: 632 ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVL 691
L ++A D GN + VTI V D DNPP FS+ AY V EN+ G V
Sbjct: 756 --KTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVG 813
Query: 692 FLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDG 751
++A+ +D + +I + + F IN +G++TT +++DRE +S Y L V A G
Sbjct: 814 SVSASTMDLNSNISY--LITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGG 871
Query: 752 GVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG 811
V TG VNIT+ D+NDN P + A +N+VE + AVDPD G NG
Sbjct: 872 TV-----TGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNG 926
Query: 812 TLVYSI-QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 870
++YS+ Q P +++N G I + D H +I+ S D G P L +
Sbjct: 927 MVLYSLKQNPKNLFAINEKNGTISLLGPL------DVHAGSYQIEILAS--DMGVPQLSS 978
Query: 871 TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930
+ TV+V+ D+NDN P F L + + E P ++V A D D G NG ++Y +
Sbjct: 979 SVILTVYVH--DVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIA 1036
Query: 931 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVND 990
G F I G + +ELDRE Y L VVASD S+T +T+ + DVND
Sbjct: 1037 EGNTGDAFGI-FPDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVND 1095
Query: 991 ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDA 1050
P F Y E+ V ++ D D G N E+ Y V F +
Sbjct: 1096 NRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFE--MVQPDFELHAISG 1153
Query: 1051 VVRTVVGLDRET------TAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
+ DRE+ TA + + A D G + + ATV V + D+NDN P FL+
Sbjct: 1154 EITNTHQFDRESLMRRRGTAVFSFTVIATDQG-IPQPLKDQATVHVYMKDINDNAPKFLK 1212
Query: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPR 1164
Y+A++ E +L++ A+D DEG G + Y I+ GN F I ++G + +
Sbjct: 1213 DFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGK 1272
Query: 1165 PLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGI 1224
LD E ++ L+++A + P+ S+ + + + D ND P F + + + E I
Sbjct: 1273 -LDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKSTLF-VDVLENMRI 1330
Query: 1225 GTSVIVVQATDRDSGDGGLVNYRIL-SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNV 1283
G V V ATD DSGD + Y I + G F I +TG I LD+ET++ Y +N+
Sbjct: 1331 GELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNI 1390
Query: 1284 SATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNL 1343
+A DQ P SV I + + D F +I+EN+ +GT ++ V A+ D
Sbjct: 1391 TAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDAD 1450
Query: 1344 NQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVD---- 1399
+ F ID + G I +DRE + + LTV A+D ++
Sbjct: 1451 INGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRY 1510
Query: 1400 STVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLA 1459
+ V I V D NDN P F S +A++ +G + T+ A DPD G+NG++ + +
Sbjct: 1511 ALKNVTILVTDLNDNVPM--FISQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEII 1568
Query: 1460 SGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILD 1519
+G+ + + G++ VA L +L Y L V A+D G P ++ ++TI+
Sbjct: 1569 NGDT----DTFIVDRYSGDLRVASALVPSQL-IYNLIVSATDLG--PERRKSTTELTIIL 1621
Query: 1520 INDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT-----EGNKDM 1574
+ PV P Y + E GT V+ + A G + + YYI E
Sbjct: 1622 QGLDGPVFTQP-KYITILKEGEPIGTNVISIEAAS-PRGSEAPVEYYIVSVRCEEKTVGR 1679
Query: 1575 AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSAT--THVYVTIVDENDNAP 1632
F + R +G I T A DRE+ + +LV E + T V +T+ D NDN P
Sbjct: 1680 LFTIGRHTGIIQT-AAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPP 1738
Query: 1633 MFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVI 1692
+F ++ ++E + ++ + A+D DEG N VTY I++G ++FRID G +
Sbjct: 1739 VFPTDMLDLTVEENIGD-GSKIMQLTAMDADEGANALVTYTIISG-ADDSFRIDPESGDL 1796
Query: 1693 TAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPF 1752
A + LD E +Y+L+V A D +S + + V+D+ND+ P F R F
Sbjct: 1797 IATRRLDRE-RRSKYSLLVRADDGLQ------SSDMRINITVSDVNDHTPKFSRPVYS-F 1848
Query: 1753 EVTEGQ-PGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDR 1811
++ E PG V LA D DSG NG++ Y + + D G F ++P+ GV + + LD
Sbjct: 1849 DIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPITGVFNLTR--LLDY 1906
Query: 1812 ETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVA 1871
E +Y LT+ A D G +T+ V +LD+NDN P+ + ++ EN PV S V
Sbjct: 1907 EVQQYYILTVRAEDGG--GQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVL 1964
Query: 1872 HVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN 1931
+DAD G N++LT++I +G+ F ++ G++ V + LDRE Y L + V D
Sbjct: 1965 VFNVTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDRESQSFYNLVVQVHDL 2023
Query: 1932 PENPRIARRDYDLLLIFLSDENDNHPLF--TKSTYQAEVMENSPAGTPLTVLNGPILALD 1989
P+ P + I L D NDN P F K TY P TP+ + A D
Sbjct: 2024 PQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-------IPENTPIDTVVFKAQATD 2076
Query: 1990 ADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLL 2049
D + + Y LL F I + G V + +DRE S L ++ + L
Sbjct: 2077 PDSGPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGE--LDREEVSNYTLTVVATDKGQPSL 2134
Query: 2050 NSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIE 2109
+S+ +++ +LD NDN P F+ A V + EN G ++QV A D D G NG++ Y I
Sbjct: 2135 SSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIV 2194
Query: 2110 AG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIN 2168
G F I VTG I V +DRE+ +Y LTV ATDRG+ P + T+ V+I++ DIN
Sbjct: 2195 NGNTNQEFRIDSVTGAITVAK-PLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDIN 2253
Query: 2169 DSRPEFLNPIQTVSVLESAEPGTV---IANITAIDHD--LNPKLEYHIVGIVAKDDTDRL 2223
D P F +V+V E+ GT+ I + A D D N KL Y + G
Sbjct: 2254 DFVPVFELSPYSVNVPENL--GTLPRTILQVVARDDDRGSNSKLSYVLFG---------- 2301
Query: 2224 VPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNV 2283
N+++AF ++ +G + V ++RE + + ++ D+ S + V V
Sbjct: 2302 -GNEDNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGS-----PALTGTGTINVIV 2354
Query: 2284 LDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGY 2343
DVNDN P F Y I E A GT ++ V A D D N ++ + G
Sbjct: 2355 DDVNDNVP---TFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIR------IIGGN 2405
Query: 2344 VQLE-DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP-PRAAEIPVYLEIVDINDNNPI 2401
Q + S G++I + +D E V SD GSP P ++ V + + D+NDN P
Sbjct: 2406 SQFTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPR 2465
Query: 2402 FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-GDGESKFAINPTTGDIYVL 2460
F Y + G+ + VT TDAD G + + YSL G KF I+P G I
Sbjct: 2466 FQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAA 2525
Query: 2461 SSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYE 2520
L+ + + + + D S + +S V ++ ++ D P+ + + E
Sbjct: 2526 GPLNGASEVTFSV------HVKDGGSFPKTDSTTVTVRFVNKADF-PKVRAKEQTFMFPE 2578
Query: 2521 NEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFS 2578
N+P + V T+ + P Y G F +D +G V+ +PL + +K+
Sbjct: 2579 NQPVSSLVTTITGSSLRGEPMS--YYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYV 2636
Query: 2579 LTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYAT 2638
+ + A DGG PP L + V+DVNDN P+F P I I E + R + V A
Sbjct: 2637 VWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDP--FISEILENLSPR-KILTVSAM 2693
Query: 2639 DKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQ 2698
DKD G NG + Y + GN + F I+ +G I++ + LDRE + Y L + +SD G
Sbjct: 2694 DKDSGPNGQLDYEIVN--GNME-NSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGS 2750
Query: 2699 PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE 2758
P T + + + D +DN P F Q VPE+SP G V VT + D D
Sbjct: 2751 P-SQSTSVKVMINILDENDNAPRF-------SQIFSAHVPENSPLGYTVTRVTTS-DEDI 2801
Query: 2759 GPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGP 2817
G NAI Y I + F + P G +++ R L+RE + V A + WT
Sbjct: 2802 GINAISRYSIM--DASLPFTINPSTGDIVISRPLNREDTDRYRIRVSAHDS-GWT----- 2853
Query: 2818 SPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGN 2877
+V + + DIND PRF++ Y ++GS++ QV A D D G+
Sbjct: 2854 ----------VSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGS 2903
Query: 2878 NSLVFYSILA-IHYFRALANDSE 2899
N VFY I + YFR A E
Sbjct: 2904 NGQVFYFIKSQSEYFRINATTGE 2926
Score = 1002 bits (2591), Expect = 0.0
Identities = 876/2928 (29%), Positives = 1356/2928 (46%), Gaps = 215/2928 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASR-FFAVEPDTGVVWLRQPLDRET 97
+ E+ P G+ + L A D D N + F + E R F ++P +G + LDRE
Sbjct: 592 VVENAPTGTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREE 651
Query: 98 KSEFTVEFSVSD----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI 153
++ +++ +D Q + R +N+ + D+NDN+P F+ Y I EN P G+ I
Sbjct: 652 QAFYSLLVLATDLGSPPQSSMAR-INVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITT 710
Query: 154 VNATDPDLGAGGSVLYSFQPPSQF-FAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK 212
V+ATDPDLG G+V YS + F +++ G+++ LD E AYQL + ATD
Sbjct: 711 VSATDPDLGTNGTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGN 770
Query: 213 TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
+ + A + I + D QD P+F + YS ++E+ G V ++A D I
Sbjct: 771 LQSPNQ-AIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNS--NIS 827
Query: 273 YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
Y I +G+ +FA++ ++G LT ++DRE + ++ GT D T
Sbjct: 828 YLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVASGGTVTGD----------T 877
Query: 333 TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG 392
NI V D+NDN+P F + SV + E Q G ++ + VD DE G+N M L
Sbjct: 878 MVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSI-FQAKAVDPDE--GVNGMVLYSLKQ 934
Query: 393 NNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLI 451
N + F I+ + + I + PLD Y ++ A++ VP + + +
Sbjct: 935 NPKNLFAIN------EKNGTISLLGPLDVHA-GSYQIEILASDMGVPQLSSSVILTVYVH 987
Query: 452 NENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP--DRFSLD 509
+ NDN P+F Q Y ++L E+ V + V A+D D+G GE++Y ++ D F +
Sbjct: 988 DVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIF 1047
Query: 510 KDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYV 567
D G + + + LD EL R+ L ++A D E + V + V+ DVNDN P F Y
Sbjct: 1048 PD-GQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNVTVILEDVNDNRPLFNSTNYT 1106
Query: 568 GALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPL 627
E + + + + ++ A D+D PN ++ YS D L+ G I+ +
Sbjct: 1107 FYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQP-----DFELHAISGEITNTHQF 1161
Query: 628 DYEQI----SNGLIYLTVMAMDAGNP-PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVE 682
D E + + TV+A D G P PL V + + D NDN P F K Y ++ E
Sbjct: 1162 DRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISE 1221
Query: 683 NIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEY 742
+ VL ++A+D+D I QF I++ SG++T LD E Y
Sbjct: 1222 SAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAY 1281
Query: 743 ILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVA 802
L+++AVD G T T+NI +LD NDN P++ + +++++E V++V A
Sbjct: 1282 SLVIQAVDSGTIPLNST--CTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTA 1339
Query: 803 VDPDLGENGTLVYSIQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSV 860
D D G+N L YSI N +S++ TG I + E + + K+ ++
Sbjct: 1340 TDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKL-------DFETQSLYKLNITA 1392
Query: 861 TDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEG 920
D GRPP +T S + V D NDN P+F ++E IP G S+ V A D D
Sbjct: 1393 KDQGRPPRSSTMSVVIHVR--DFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDAD 1450
Query: 921 LNGLVSYRMPVGMPRMD-FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKS--- 976
+NG +SY + MPR + F I+ G + T E+DRE ++L V A+D P ++
Sbjct: 1451 INGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRY 1510
Query: 977 STSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036
+ +TI V D+ND P F + ++ + + D D G N E+ Y I
Sbjct: 1511 ALKNVTILVTDLNDNVPMFI-SQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIIN 1569
Query: 1037 GNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVN 1096
G+ D F V +R L + Y LI+ A D GP ++ T T+ + LD
Sbjct: 1570 GDTD-TFIVDRYSGDLRVASALV-PSQLIYNLIVSATDLGPERRKSTTELTIILQGLD-- 1625
Query: 1097 DNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWY----RILHGNHGNNFRI 1152
P+F Q Y + E P G +++ ++A E +Y R G F I
Sbjct: 1626 --GPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTI 1683
Query: 1153 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG---PMRSSVRVIVYVEDINDEAPVFT 1209
G++ LDRE+ + + +V+ Y + P V + ++DIND PVF
Sbjct: 1684 GRHTGIIQTAAI-LDREQGAC-LYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFP 1741
Query: 1210 QQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVN 1269
L + E G G+ ++ + A D D G LV Y I+SGA+ F ID +G +I
Sbjct: 1742 TDMLD-LTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATR 1800
Query: 1270 YLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALG 1329
LD E ++ Y + V A D + + IT+ + D +FS Y I E+ G
Sbjct: 1801 RLDRERRSKYSLLVRADDGLQSSDM---RINITVSDVNDHTPKFSRPVYSFDIPEDTIPG 1857
Query: 1330 TEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTL 1387
+ + + A D+ +ITY N +F ++ ITGV + L+D E +Y L
Sbjct: 1858 SLVAAILATDDDSGVNGEITYIVN---EDDEDGIFFLNPITGVFNLTRLLDYEVQQYYIL 1914
Query: 1388 TVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPD 1447
TV A+DGG + +T++VY +LD NDN P F S S S+ E+ PVG V D D
Sbjct: 1915 TVRAEDGGGQF-TTIRVYFNILDVNDNPPIFSLNSYST-SLMENLPVGSTVLVFNVTDAD 1972
Query: 1448 AGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPR 1507
G N Q+ +S+ASG+ G F + D G + V + LDRE Y L V D P
Sbjct: 1973 DGINSQLTYSIASGDSLGQFTV----DKNGVLKVLKALDRESQSFYNLVVQVHDLPQIPA 2028
Query: 1508 KK---DHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLS 1564
+ + + +LD+NDNPP SP + EN T V + +ATD D G NS +
Sbjct: 2029 SRFTSTAQVSIILLDVNDNPPTFLSP--KLTYIPENTPIDTVVFKAQATDPDSGPNSYIE 2086
Query: 1565 YYITE--GNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYV 1622
Y + GNK F + I GE+ DRE S Y L D+G P+LS++T V V
Sbjct: 2087 YTLLNPLGNK---FSIGTIDGEVRLT-GELDREEVSNYTLTVVATDKGQPSLSSSTEVVV 2142
Query: 1623 TIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNT 1682
++D NDN P+F Q Y+V ++E T T +I + A D DEG NG V Y IV GN
Sbjct: 2143 MVLDINDNNPIFAQALYKVEINENTLT-GTDIIQVFAADGDEGTNGQVRYGIVNGNTNQE 2201
Query: 1683 FRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVP 1742
FRID G IT AK LD E + Y L V ATD+ S T T+TV + + DIND VP
Sbjct: 2202 FRIDSVTGAITVAKPLDREKTP-TYHLTVQATDRG---STPRTDTSTVSIVLLDINDFVP 2257
Query: 1743 TFPRDYEGPFEVTE----GQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVE 1798
F P+ V G + +A D D G N ++ Y + G+ F +S
Sbjct: 2258 VFELS---PYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLS-AS 2313
Query: 1799 GVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNI 1858
G L V + LDRET + L I A D G P L+ T + + V D+NDN P +
Sbjct: 2314 GELGVTQS--LDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFT 2371
Query: 1859 TISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRER 1918
TI E++P + V V ASDAD+ NA I GN + F IN +TG + + LDRE
Sbjct: 2372 TIPEDAPTGTDVLLVNASDADASKNA--VIRIIGGNSQ--FTINPSTGQIITSALLDRET 2427
Query: 1919 IPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPL 1978
Y L + D ++ +L+ ++D NDN P F Y + + G+ +
Sbjct: 2428 KDNYTLVVVCSDAGSPEPLSSSTS--VLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFV 2485
Query: 1979 TVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREA-FSPPIL 2037
+ DAD + + Y L G S F I+ G + + E FS +
Sbjct: 2486 FA----VTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPLNGASEVTFSVHV- 2540
Query: 2038 ELLLLAEDIGLLNSTAHLLITILDDND-NRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2096
+D G T +T+ N + P T EN P V +T
Sbjct: 2541 ------KDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITG--- 2591
Query: 2097 DSGLNGE-LVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPL 2154
S L GE + Y I +G + F I +TG + + +D E+ + Y + + A D G P
Sbjct: 2592 -SSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQP-LDFEKIQKYVVWIEARDGGFPPF 2649
Query: 2155 SGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP--KLEYHIV 2212
S + I + D+ND+ P F +LE+ P ++ ++A+D D P +L+Y IV
Sbjct: 2650 SSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILT-VSAMDKDSGPNGQLDYEIV 2708
Query: 2213 GIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
N E++F++N TG + P++RE V+ Y +T+ D S P +S
Sbjct: 2709 N-----------GNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGS--PSQST 2755
Query: 2273 SVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVT 2332
SV K+ +N+LD NDN P+F + + E + G T+ V D D G+N +
Sbjct: 2756 SV---KVMINILDENDNAPRFSQI----FSAHVPENSPLGYTVTRVTTSDEDIGINAISR 2808
Query: 2333 YTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEI 2392
Y+++D P + + S G ++ +R ++ E+ V A D+G V + +
Sbjct: 2809 YSIMDASLPFTI---NPSTGDIVISRPLNREDTDRYRIRVSAHDSGW---TVSTDVTIFV 2862
Query: 2393 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINP 2452
DINDN P F + SY E +G+ + V ATD D G+ + Y + F IN
Sbjct: 2863 TDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINA 2922
Query: 2453 TTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSV----QVVIQVLDVNDCRPQ 2508
TTG+I+ L + + + + + +S+R + S+ V I ++D ND PQ
Sbjct: 2923 TTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIVDSNDNAPQ 2982
Query: 2509 FSKPQFSTSVYENEPAGTSVITMMATD-QDEGPNGELTYSLEGPG-VEAFHVDMDSGLVT 2566
F K ++ T V +N GT +I + A D +D G N E+ Y + + F +D D+G ++
Sbjct: 2983 FLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWIS 3042
Query: 2567 TQRPLQS--YEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIRE 2624
L S + F +TV A D G PPL + + V + N + P F + I E
Sbjct: 3043 VASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSAT--IPE 3100
Query: 2625 EIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQ 2684
+ S V V A D+D +NG ++YS ++GN + F I+ +G++ A+ LD E
Sbjct: 3101 SHSIGSIVRTVSARDRDAAMNGLIKYSI--SSGNEEG-IFAINSSTGILTLAKALDYELC 3157
Query: 2685 AVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRG 2744
+ + + A D G V + V + D++DN P+F+ S Y TV E++P G
Sbjct: 3158 QKHEMTISAIDGGW-VARTGYCSVTVNVIDVNDNSPVFL-----SDDY-FPTVLENAPSG 3210
Query: 2745 TLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIV 2803
T V ++ A DAD G NA++ Y + + + + F + P+ G + LD E + + V
Sbjct: 3211 TTVIHLN-ATDADSGTNAVIAYTVQSSDSDL-FVIDPNTGVITTQGFLDFETKQSYHLTV 3268
Query: 2804 KASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGS 2863
KA + P + + T V + L+ N+ PRF Y ++ A G+
Sbjct: 3269 KAFN----------VPDEERCSFAT---VNIQLKGTNEYVPRFVSKLYYFEISEAAPKGT 3315
Query: 2864 ELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMD 2911
+ +V A D D+G + V Y I + ++ GQ++ G +D
Sbjct: 3316 IVGEVFASDRDLGTDGEVHYLIFGNSRKKGF-QINKKTGQIYVSGILD 3362
Score = 1002 bits (2591), Expect = 0.0
Identities = 878/2890 (30%), Positives = 1368/2890 (47%), Gaps = 202/2890 (6%)
Query: 41 LISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
++ E+ +G V + A MD N + + ++ + FA+ TG + +DRE +S
Sbjct: 801 VVFENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQS 860
Query: 100 EFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDP 159
+ ++ S VNI V D+NDN+P F SV + EN G IF A DP
Sbjct: 861 FYQLKVVASGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDP 920
Query: 160 DLGAGGSVLYSF-QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLST 218
D G G VLYS Q P FAI+ G ++++ LD +YQ+ + A+D + LS+
Sbjct: 921 DEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAG-SYQIEILASDMGVPQ-LSS 978
Query: 219 LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSG 278
L + + DV D P+F L Y + E P + + A D+D G I YTI G
Sbjct: 979 SVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEG 1038
Query: 279 NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILV 338
NT F + + G L + LDRE ++L V + DR + T +++
Sbjct: 1039 NTGDAFGI-FPDGQLYIKSELDRE---LQDRYVLMVVAS----DRAVEPLSATVNVTVIL 1090
Query: 339 IDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD--ENLGLNSMFEVYLVGNNSH 396
D+NDN P FNS+ Y+ E + G + + VDKD N + FE+ H
Sbjct: 1091 EDVNDNRPLFNSTNYTFYFEEEQRAGSFVGK-VSAVDKDFGPNGEVRYSFEMVQPDFELH 1149
Query: 397 HFIISPTSVQGKADIRIRVAIPLDYETVDR------YDFDLFA-NESVPDHV-GYAKVKI 448
++ G+ I D E++ R + F + A ++ +P + A V +
Sbjct: 1150 -------AISGE----ITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHV 1198
Query: 449 TLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRF 506
+ + NDN P F + Y ++ E+ T VL V A+D D G G + Y ++ +F
Sbjct: 1199 YMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQF 1258
Query: 507 SLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKD 564
++D +G + LI +LDYE ++L I A D G +T + I++LD NDN P+F K
Sbjct: 1259 AIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDENDNTPSFPKS 1318
Query: 565 AYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVS 624
+ EN + + ATD DS N + YSI + G++ S+ G I ++
Sbjct: 1319 TLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTF---SISPNTGSIFLA 1375
Query: 625 RPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI 684
+ LD+E + L L + A D G PP +ST+ V I V D NDNPP+F F S+VENI
Sbjct: 1376 KKLDFE--TQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENI 1433
Query: 685 MAGATVLFLNATDLDRSREYGQES--IIYSLEGSTQFRINARSGEITTTSLLDRETKSEY 742
G +V+ + A D D GQ S II + F I+ G I T + +DRE + +
Sbjct: 1434 PIGTSVISVTAHDPDADIN-GQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLF 1492
Query: 743 ILIVRAVDGGVG-HNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP---DSDVT 798
L V+A D V ++ + V I + D+NDN P + N + P S +T
Sbjct: 1493 ELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQ----NALAADPSAVIGSVLT 1548
Query: 799 TVVAVDPDLGENGTLVYSI-QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIV 857
T++A DPD G NG + Y I + ++ +G +R A++ ++L+ ++
Sbjct: 1549 TIMAADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASALVP--------SQLIYNLI 1600
Query: 858 VSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDL 917
VS TD G K+T+ T+ + LD P F ++ + EG P G ++ + A
Sbjct: 1601 VSATDLGPERRKSTTELTIILQGLD----GPVFTQPKYITILKEGEPIGTNVISIEAAS- 1655
Query: 918 DEGLNG-----LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA-EYQLRVVASDAG 971
G +VS R F I +G++ T LDRE+ A Y + V A +
Sbjct: 1656 PRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKS 1715
Query: 972 TP-TKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAEL 1030
T ++ + + I + D+ND P F + +++V E++ +++ L D D G NA +
Sbjct: 1716 TAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALV 1775
Query: 1031 SYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFV 1090
+Y I G D F + + LDRE + Y L++ A D + + +
Sbjct: 1776 TYTIISG-ADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDG-----LQSSDMRINI 1829
Query: 1091 TVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNF 1150
TV DVND+ P F + Y +PED G + + ATD D G G + Y + + F
Sbjct: 1830 TVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIF 1889
Query: 1151 RIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQ 1210
++ G+ R LD E ++L V A D G +++RV + D+ND P+F+
Sbjct: 1890 FLNPITGVFNL-TRLLDYEVQQYYILTVRA--EDGGGQFTTIRVYFNILDVNDNPPIFSL 1946
Query: 1211 QQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAE-GKFEIDESTGLIITVN 1269
YS L E +G++V+V TD D G + Y I SG G+F +D++ G++ +
Sbjct: 1947 NSYST-SLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKN-GVLKVLK 2004
Query: 1270 YLDYETKTSYMMNVSATDQAPPFNQGFCS---VYITLLNELDEAVQFSNASYEAAILENL 1326
LD E+++ Y + V D F S V I LL+ D F + I EN
Sbjct: 2005 ALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKL-TYIPENT 2063
Query: 1327 ALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYT 1386
+ T + + QA D+ + K F I I G + + G +DRE+ YT
Sbjct: 2064 PIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK--FSIGTIDGEVRLTGELDREEVSNYT 2121
Query: 1387 LTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWD 1445
LTVVA D G P + S+ +V + VLD NDN+P F + V I E+ G + V A D
Sbjct: 2122 LTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFA-QALYKVEINENTLTGTDIIQVFAAD 2180
Query: 1446 PDAGSNGQVVFSLASGNIAGAFEIVTTNDSI-GEVFVARPLDREELDHYILQVVASDRGT 1504
D G+NGQV + + +GN F I DS+ G + VA+PLDRE+ Y L V A+DRG+
Sbjct: 2181 GDEGTNGQVRYGIVNGNTNQEFRI----DSVTGAITVAKPLDREKTPTYHLTVQATDRGS 2236
Query: 1505 PPRKKDHILQVTILDINDNPPVIE-SPFGYNVSVNENVGG-GTAVVQVRATDRDIGINSV 1562
PR + + +LDIND PV E SP Y+V+V EN+G ++QV A D D G NS
Sbjct: 2237 TPRTDTSTVSIVLLDINDFVPVFELSP--YSVNVPENLGTLPRTILQVVARDDDRGSNSK 2294
Query: 1563 LSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYV 1622
LSY + GN+D AF + SGE+ + DRE + + L+ T D G+P L+ T + V
Sbjct: 2295 LSYVLFGGNEDNAFTLSA-SGELGVTQSL-DRETKERFVLMITATDSGSPALTGTGTINV 2352
Query: 1623 TIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNT 1682
+ D NDN P F Y + E T T ++ + A D D N + I+ GN +
Sbjct: 2353 IVDDVNDNVPTFASKAYFTTIPEDAPT-GTDVLLVNASDADASKNAVIR--IIGGN--SQ 2407
Query: 1683 FRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVP 1742
F I+ G I + LD E + YTL+V +D L+S+T+VLV V D+NDN P
Sbjct: 2408 FTINPSTGQIITSALLDRE-TKDNYTLVVVCSDAGS--PEPLSSSTSVLVTVTDVNDNPP 2464
Query: 1743 TFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLR 1802
F + PG V+ D D GPN ++ YS+ G +F I P+ G +
Sbjct: 2465 RFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEKFHIDPLRGAIM 2523
Query: 1803 VRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISE 1862
+ E ++ +D G P + + V +R ++ D P + E
Sbjct: 2524 AAGPLNGASEV----TFSVHVKDGGSFPKTDSTTVTVRFVNKADF-PKVRAKEQTFMFPE 2578
Query: 1863 NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEY 1922
N PVSS V + S +++ I +GN F I+ TG V++++PLD E+I +Y
Sbjct: 2579 NQPVSSLVTTITGSSLRG---EPMSYYIASGNLGNTFQIDQLTGQVSISQPLDFEKIQKY 2635
Query: 1923 KLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
+ I +D P + Y+ L I + D NDN P+F + + +E++EN LTV
Sbjct: 2636 VVWIEARDGGFPPFSS---YEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKILTVS- 2691
Query: 1983 GPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
A+D D + Y+++ G F IN +TG +RS +DRE S +L +
Sbjct: 2692 ----AMDKDSGPNGQLDYEIVNGNMENSFSINHATG--EIRSVRPLDREKVSHYVLTIKS 2745
Query: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
+ +++ ++I ILD+NDN P FS + H+ EN P G++V +VT +DED G+N
Sbjct: 2746 SDKGSPSQSTSVKVMINILDENDNAPRFSQI-FSAHVPENSPLGYTVTRVTTSDEDIGIN 2804
Query: 2102 GELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVT 2161
Y I A F I+ TG I + ++RE+ + YR+ V A D G + VT
Sbjct: 2805 AISRYSI-MDASLPFTINPSTGDIVISRP-LNREDTDRYRIRVSAHDSGWTVSTD---VT 2859
Query: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDD 2219
I + DIND+ P F + E E G+ + + A D D N ++ Y I
Sbjct: 2860 IFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFI-------- 2911
Query: 2220 TDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYE-VTL---SVIDNASDLPERSVSVP 2275
+Q + F +N TG + K + + V + V + S I +SD + S+ +
Sbjct: 2912 -----KSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSL-IS 2965
Query: 2276 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDP-DKGLNGLVTYT 2334
+T+N++D NDN PQF + Y + + GT LI V A+D D GLN V Y
Sbjct: 2966 ETTVTINIVDSNDNAPQFLK---SKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYF 3022
Query: 2335 LLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVD 2394
+ + G +L++ + +A+ + ++ TV A D G+PP +++ V++ + +
Sbjct: 3023 ISNDNHLGKFKLDNDTGWISVASSLISDLNQNFF-ITVTAKDKGNPPLSSQATVHITVTE 3081
Query: 2395 INDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG--ESKFAINP 2452
N + P F Q + E +G+I+ TV+A D D+ LI+YS+ G E FAIN
Sbjct: 3082 ENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINS 3141
Query: 2453 TTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKP 2512
+TG + + +LD E + +T A D G VA R V + V+DVND P F
Sbjct: 3142 STGILTLAKALDYELCQKHEMTISAIDG-GWVA---RTGYCSVTVNVIDVNDNSPVFLSD 3197
Query: 2513 QFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL- 2571
+ +V EN P+GT+VI + ATD D G N + Y+++ + F +D ++G++TTQ L
Sbjct: 3198 DYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLD 3257
Query: 2572 -QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRS 2630
++ + + LTV A + + + +++ N+ P FV I E P +
Sbjct: 3258 FETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFV--SKLYYFEISEAAPKGT 3315
Query: 2631 NVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLI 2690
V EV+A+D+D G +G V Y GN + F I+ +G I + LDRE + SL
Sbjct: 3316 IVGEVFASDRDLGTDGEVHYLIF---GNSRKKGFQINKKTGQIYVSGILDREKEERVSLK 3372
Query: 2691 LVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNV 2750
++A + G + + + V + +D N+ PP + + + E P GT V V
Sbjct: 3373 VLAKNFGS-IRGADIDEVTVNVTVLDAND-----PPIFTLNIYSVQISEGVPIGTHVTFV 3426
Query: 2751 TGAVDADEGPN-AIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSN 2808
+ A D+D P+ + YFI +GNE F + P G + V +LDRE I++ V A
Sbjct: 3427 S-AFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVD- 3484
Query: 2809 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQV 2868
S TP S +L V LEDIND P T +E V + + G+ ++ +
Sbjct: 3485 -SGTPSATGSASL-----------LVTLEDINDNGPMLTVSE--GEVMENKRPGTLVMTL 3530
Query: 2869 LALDADIGNN 2878
+ D D+ N
Sbjct: 3531 QSTDPDLPPN 3540
Score = 976 bits (2522), Expect = 0.0
Identities = 873/2919 (29%), Positives = 1373/2919 (47%), Gaps = 229/2919 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ ED VGSSV Q+ A D D N + + + E F ++P+TG++ +R+PLD E +
Sbjct: 259 VPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTP--FQMDPETGLITVREPLDFEAR 316
Query: 99 SEFTVEFSVSDHQGV--ITRKVN--IQVGDVNDNAPT--FHNQPYSVR---IPENTPVGT 149
++++ D +GV +T + IQ+ DVNDN P F P + R + EN VGT
Sbjct: 317 RQYSLTVQAMD-RGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGT 375
Query: 150 PIFIVNATDPDLGAGG---SVLYSFQPPSQFFAIDSAR----GIVTVIRELDYETTQAYQ 202
+ ++ TD D A SV + F + S++ ++ V LD E +Y
Sbjct: 376 VVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYN 435
Query: 203 LTVNATDQDKTRP------LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
LTV+ +D P S++A+L I + D+ D P+F Y N+ E +PPG+ V
Sbjct: 436 LTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVS 495
Query: 257 IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTL--NGLLDRENPLYSHGFILTV 314
I+A D D G + Y+IVSGN F + SG++T +G LDRE + +L +
Sbjct: 496 GISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRE---LASQIVLNI 552
Query: 315 KGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSE-YSVAITELAQVGFALPLFIQV 373
+ S A + T ++D+ND P F+ E Y V++ E A G L L ++
Sbjct: 553 SARDQGVHPKVSYAQLVVT----LLDVNDEKPVFSQPEGYDVSVVENAPTGTEL-LMLRA 607
Query: 374 VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
D D F + + F + P S R+ LD E Y + A
Sbjct: 608 TDGDLGDNGTVRFSLQEAETDRRSFRLDPVSG------RLSTISSLDREEQAFYSLLVLA 661
Query: 434 NE-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTF 492
+ P A++ ++L++ NDN P+F Y + EN G+ + TV ATD D GT
Sbjct: 662 TDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTN 721
Query: 493 GEVSYFFS-DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGR--VRI 549
G V Y S D RF ++ +G+I LD E + L I+A DGG ++ + V I
Sbjct: 722 GTVKYSISAGDRSRFQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTI 781
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY 609
VLD DN P F + AY + EN + + A+ D N+ I+Y I + G +
Sbjct: 782 TVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDL--NSNISYLITTGDQKGMF 839
Query: 610 FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
++ + G ++ + +D E+ S + + + +G T+ V I V D NDN P
Sbjct: 840 ---AINQVTGQLTTANVIDREEQS----FYQLKVVASGGTVTGDTM-VNITVKDLNDNSP 891
Query: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGE 727
F + V+VVEN AG ++ A D D E ++YSL+ + + F IN ++G
Sbjct: 892 HFLQAIESVNVVENWQAGHSIFQAKAVDPD---EGVNGMVLYSLKQNPKNLFAINEKNGT 948
Query: 728 ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINL 787
I+ LD S Y + + A D GV + I TV + D+NDN P + Y + L
Sbjct: 949 ISLLGPLDVHAGS-YQIEILASDMGVPQLSSSVILTVYVH--DVNDNSPVFDQLSYEVTL 1005
Query: 788 VEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDP 847
E P +S V A D D G NG + Y+I N + + LDRE D
Sbjct: 1006 SESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDR 1065
Query: 848 HEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGV 907
+ ++V +D PL AT + TV L D+NDN P F + + E AG
Sbjct: 1066 Y------VLMVVASDRAVEPLSATVNVTVI--LEDVNDNRPLFNSTNYTFYFEEEQRAGS 1117
Query: 908 SIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERI------AEY 961
+ +V A+D D G NG V Y + P DF +++ SG + T + DRE + A +
Sbjct: 1118 FVGKVSAVDKDFGPNGEVRYSFEMVQP--DFELHAISGEITNTHQFDRESLMRRRGTAVF 1175
Query: 962 QLRVVASDAGTPTK-SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT 1020
V+A+D G P +T+ +++ D+ND P F Y ++SE +V+ ++ +
Sbjct: 1176 SFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQATISESAANLTQVLRVSAS 1235
Query: 1021 DNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGK 1080
D D G N + Y I GN + +F++ V + LD E T AY L+++A+D+G +
Sbjct: 1236 DVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPL 1295
Query: 1081 RHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYR 1140
T T+ + +LD NDN P F +S+ V E++ G + + ATD+D G+ ++Y
Sbjct: 1296 --NSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYS 1353
Query: 1141 ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVED 1200
I N+ F I + G + + LD E S + L + A + P S++ V+++V D
Sbjct: 1354 ITGTNNHGTFSISPNTGSIFLA-KKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRD 1412
Query: 1201 INDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAE--GKFEI 1258
ND P F + + E IGTSVI V A D D+ G ++Y I+ F I
Sbjct: 1413 FNDNPPSFPPGDIFK-SIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTI 1471
Query: 1259 DESTGLIITVNYLDYETKTSYMMNVSATDQAPPF-NQGFCSVYITLL-NELDEAVQFSNA 1316
DE G I T +D E + + V A DQA P + + +T+L +L++ V +
Sbjct: 1472 DEVKGTIYTNAEIDREFANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFIS 1531
Query: 1317 SYEAAILENLALGTEIVRVQAYSIDN--LNQITYR-FNAYTSTQAKALFKIDAITGVITV 1373
A + +G+ + + A D +I Y N T T F +D +G + V
Sbjct: 1532 QNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDT-----FIVDRYSGDLRV 1586
Query: 1374 -QGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSI-PED 1431
LV + Y L V A D GP+ + +L D FT ++I E
Sbjct: 1587 ASALVPSQL--IYNLIVSATDLGPERRKSTTELTIILQGLDGPV---FTQPKYITILKEG 1641
Query: 1432 CPVGQRVATVKAWDPDAGSNGQVVFSLASGNI--AGAFEIVTTNDSIGEVFVARPLDREE 1489
P+G V +++A P GS V + + S + T G + A LDRE+
Sbjct: 1642 EPIGTNVISIEAASP-RGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQ 1700
Query: 1490 -LDHYILQVVASDRGTP-PRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
Y++ V A ++ T PR + +++T+ DINDNPPV + +++V EN+G G+ +
Sbjct: 1701 GACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDM-LDLTVEENIGDGSKI 1759
Query: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE-IATRPAPPDRERQSFYHLVATV 1606
+Q+ A D D G N++++Y I G D +FR+D SG+ IATR DRER+S Y L+
Sbjct: 1760 MQLTAMDADEGANALVTYTIISGADD-SFRIDPESGDLIATRRL--DRERRSKYSLLVRA 1816
Query: 1607 EDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDLDEG 1665
+D S+ + +T+ D ND+ P F +P Y + E DT+ SL+ I A D D G
Sbjct: 1817 DD---GLQSSDMRINITVSDVNDHTPKFSRPVYSFDIPE--DTIPGSLVAAILATDDDSG 1871
Query: 1666 PNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLT 1725
NG +TY + + F ++ GV + LDYE+ Y L V A D
Sbjct: 1872 VNGEITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQ-YYILTVRAED-----GGGQF 1925
Query: 1726 STTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMD 1785
+T V N+ D+NDN P F + + G V F D D G N Q+ YSI
Sbjct: 1926 TTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIAS 1985
Query: 1786 GDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLS---STMLVGIRVL 1842
GD LG+F + GVL+V K LDRE+ +FYNL + D P S ST V I +L
Sbjct: 1986 GDSLGQFTVDK-NGVLKVLK--ALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILL 2042
Query: 1843 DINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI--TAGNRERAFF 1900
D+NDN P L+ P I EN+P+ + V A+D DSG N+ + + + GN+ F
Sbjct: 2043 DVNDNPPTFLS-PKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNK---FS 2098
Query: 1901 INATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFT 1960
I G V + LDRE + Y LT+ D + + + +++ + D NDN+P+F
Sbjct: 2099 IGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTE---VVVMVLDINDNNPIFA 2155
Query: 1961 KSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVV 2019
++ Y+ E+ EN+ GT + + A D D+ V Y ++ G + F I+S TG +
Sbjct: 2156 QALYKVEINENTLTGTDII----QVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAI 2211
Query: 2020 TVRSGVIIDREAFSPPILELLLLAEDIGLL--NSTAHLLITILDDNDNRPTFSPATLTVH 2077
TV +DRE P L + A D G T+ + I +LD ND P F + +V+
Sbjct: 2212 TVAKP--LDRE--KTPTYHLTVQATDRGSTPRTDTSTVSIVLLDINDFVPVFELSPYSVN 2267
Query: 2078 LLENCPP-GFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREE 2136
+ EN ++LQV A D+D G N +L Y + G +D +G + V ++DRE
Sbjct: 2268 VPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGV-TQSLDRET 2326
Query: 2137 QESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANI 2196
+E + L + ATD G+ L+GT + +++DD+ND+ P F + ++ E A GT + +
Sbjct: 2327 KERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLV 2386
Query: 2197 TAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEV 2256
A D D + I+G F +N +TG ++ + ++RE Y +
Sbjct: 2387 NASDADASKNAVIRIIG-------------GNSQFTINPSTGQIITSALLDRETKDNYTL 2433
Query: 2257 TLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
+ D S P S + + V V DVNDN P+F+ Y+ I PG+ +
Sbjct: 2434 VVVCSDAGSPEPLSS----STSVLVTVTDVNDNPPRFQHHP---YVTHIPSPTLPGSFVF 2486
Query: 2317 AVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASD 2376
AV D D G N + Y+L + D G ++A ++ + F+V D
Sbjct: 2487 AVTVTDADIGPNSELHYSLSGRNSEKF--HIDPLRGAIMAAGPLN--GASEVTFSVHVKD 2542
Query: 2377 NGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVF---EDVPVGTIILTVTATD--ADS 2431
GS P+ V + V N F + +E F E+ PV +++ T+T + +
Sbjct: 2543 GGSFPKTDSTTVTVRFV----NKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEP 2598
Query: 2432 GNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRREN 2491
++ + +LG + F I+ TG + + LD EK Y++ A+D S+
Sbjct: 2599 MSYYIASGNLG---NTFQIDQLTGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYE-- 2653
Query: 2492 SVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP 2551
++ I VLDVND P F + F + + EN + ++T+ A D+D GPNG+L Y +
Sbjct: 2654 --KLDITVLDVNDNAPIFKEDPFISEILEN-LSPRKILTVSAMDKDSGPNGQLDYEIVNG 2710
Query: 2552 GVE-AFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNR 2608
+E +F ++ +G + + RPL + + LT+ ++D G P + +++ ++D NDN
Sbjct: 2711 NMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDENDNA 2770
Query: 2609 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 2668
P F + + H+ E PL V V +D+D G+N RYS + + F I+P
Sbjct: 2771 PRFSQIFSA---HVPENSPLGYTVTRVTTSDEDIGINAISRYSIMDASLP-----FTINP 2822
Query: 2669 ISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKG 2728
+G I ++ L+RE Y + + A D G V + + + + DI+DN P F R
Sbjct: 2823 STGDIVISRPLNREDTDRYRIRVSAHDSGWTVSTD----VTIFVTDINDNAPRFSRTS-- 2876
Query: 2729 SPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVL 2788
L PE + G+ V V A D DEG N V+YFI + +E + G +
Sbjct: 2877 ----YYLDCPELTEIGSKVTQVF-ATDPDEGSNGQVFYFIKSQSEYFRIN-ATTGEIFNK 2930
Query: 2789 RDLDREREAIFSFI-VKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFT 2847
+ L + FS + + S + RG L+++ T V + + D ND P+F
Sbjct: 2931 QILKYQNVTGFSNVNINRHSFIVTSSDRGKP---SLISETT---VTINIVDSNDNAPQFL 2984
Query: 2848 KAEYTAGVATDAKVGSELIQVLAL-DADIGNNSLVFYSI 2885
K++Y V + KVG++LI+V A+ D D G NS V Y I
Sbjct: 2985 KSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFI 3023
Score = 970 bits (2507), Expect = 0.0
Identities = 855/2630 (32%), Positives = 1249/2630 (47%), Gaps = 209/2630 (7%)
Query: 245 IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENP 304
+ E PPGT V I RP G+T ++++FA++ +G L +DRE+
Sbjct: 51 VLEEQPPGTLVGTIQT------RP---GFTYRLSESHALFAINSSTGALYTTSTIDRES- 100
Query: 305 LYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVG 364
+ +N S T T +LV D+NDNAP F V E + G
Sbjct: 101 ---------LPSDVINLVVLSSAPTYPTEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSG 151
Query: 365 FALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPT---SVQGKADIRIRVAIPLDY 421
+ L + G++ + GN + F + T S +G A + + LD
Sbjct: 152 RQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSGEG-AFLHLVSKGGLDR 210
Query: 422 ETVDRYDFDL-FANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
E +Y + ++ P GY +V +T+ + NDN P+F Y + E+ VG+SVL
Sbjct: 211 EVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVL 270
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG 540
V A D D GT ++ Y D+ F +D +TGLI + LD+E ++++LT+ A D G
Sbjct: 271 QVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMDRGV 330
Query: 541 EETTGRVR--INVLDVNDNVPT-----FQKDAYVGALRENEPSVTQLVRLRATDEDSP-P 592
TGR I +LDVNDN P F + ++ EN T + L TD DSP
Sbjct: 331 PSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAA 390
Query: 593 NNQITYSIVSASAFGSYFDI--SLYEGYGVISVSRPLDYEQISNGLIYLTVMAMD-AGNP 649
N I+ I+ + +F++ S +I V+ LD E+I + LTV D G P
Sbjct: 391 NGNISVQILGGNE-QRHFEVQSSKVPNLSLIKVASALDRERIPS--YNLTVSVSDNYGAP 447
Query: 650 P------LNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSRE 703
P +S + I V D ND+PP FS+ Y V++ E G+ V ++ATD D
Sbjct: 448 PGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGDSGLN 507
Query: 704 YGQESIIYSLEGSTQFRINARSGEITTTSL--LDRETKSEYILIVRAVDGGVGHNQKTGI 761
I S G F I+ SG +TT S LDRE S+ +L + A D GV + K
Sbjct: 508 ANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGV--HPKVSY 565
Query: 762 ATVNITLLDINDNHPTWKDAP-YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ-- 818
A + +TLLD+ND P + Y +++VE P +++ + A D DLG+NGT+ +S+Q
Sbjct: 566 AQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLGDNGTVRFSLQEA 625
Query: 819 -PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
+ + L+ +G++ +T + LDRE + ++V TD G PP +S A +
Sbjct: 626 ETDRRSFRLDPVSGRL-STISSLDREE------QAFYSLLVLATDLGSPP--QSSMARIN 676
Query: 878 VNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD 937
V+LLD+NDN P F + + A + E P G I V A D D G NG V Y + G R
Sbjct: 677 VSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNGTVKYSISAG-DRSR 735
Query: 938 FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFP 997
F +N+ SGV+ T LDRE YQL++VA+D G + + +TI VLD D P F
Sbjct: 736 FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPNQAIVTITVLDTQDNPPVFSQ 795
Query: 998 AVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVG 1057
Y+ V E+V + V ++ + D LN+ +SY IT G+ G F++ + T
Sbjct: 796 VAYSFVVFENVALGYHVGSVSASTMD--LNSNISYLITTGDQKGMFAINQVTGQLTTANV 853
Query: 1058 LDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPE 1117
+DRE + Y L + A G TG V +TV D+NDN P FLQ+ +V E+
Sbjct: 854 IDREEQSFYQLKVVA-----SGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQA 908
Query: 1118 GHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLL-MRGPRPLDRERNSSHVL 1176
GHSI Q KA D DEG G V Y L N N F I+ NG + + G PLD S +
Sbjct: 909 GHSIFQAKAVDPDEGVNGMVLYS-LKQNPKNLFAINEKNGTISLLG--PLDVHAGSYQIE 965
Query: 1177 IVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDR 1236
I+ A + + + SSV + VYV D+ND +PVF Q Y + L E+ + + VQA+D+
Sbjct: 966 IL-ASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSY-EVTLSESEPVNSRFFKVQASDK 1023
Query: 1237 DSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGF 1296
DSG G + Y I G G G + + LD E + Y++ V A+D+A
Sbjct: 1024 DSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSAT 1083
Query: 1297 CSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYT 1354
+V + L + D F++ +Y E G+ + +V A D ++ Y F
Sbjct: 1084 VNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFE--- 1140
Query: 1355 STQAKALFKIDAITGVITVQGLVDREK------GDFYTLTVVADDGG----PKVDSTVKV 1404
+ F++ AI+G IT DRE ++ TV+A D G K +TV V
Sbjct: 1141 --MVQPDFELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHV 1198
Query: 1405 YITVLDENDNSPRF--DFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGN 1462
Y+ D NDN+P+F DF +I E +V V A D D G+NG + +S+ GN
Sbjct: 1199 YMK--DINDNAPKFLKDFYQ---ATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGN 1253
Query: 1463 IAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDIND 1522
F I +T+ G+V + LD E Y L + A D GT P L + ILD ND
Sbjct: 1254 EERQFAIDSTS---GQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDEND 1310
Query: 1523 NPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRIS 1582
N P + V V EN+ G V V ATD D G N+ L Y IT N F + +
Sbjct: 1311 NTPSFPKSTLF-VDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNT 1369
Query: 1583 GEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPH-YEV 1641
G I D E QS Y L T +D+G P S+T V + + D NDN P F ++
Sbjct: 1370 GSIFL-AKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKS 1428
Query: 1642 LLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAG-NIVNTFRIDRHMGVITAAKELDY 1700
+++ P + TS+I++ A D D NG ++Y I+ N F ID G I E+D
Sbjct: 1429 IVENIP--IGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDR 1486
Query: 1701 EISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPG 1760
E ++ + L V A DQ + R + V + V D+NDNVP F + G
Sbjct: 1487 EFAN-LFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNALAAD-PSAVIG 1544
Query: 1761 PRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLT 1820
+ T +A D D G NG++EY I++GD F++ G LRV + + YNL
Sbjct: 1545 SVLTTIMAADPDEGANGEIEYEIINGD-TDTFIVDRYSGDLRVASALVPSQ---LIYNLI 1600
Query: 1821 ICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITI-SENSPVSSFVAHVLASDAD 1879
+ A D G ST + I + + D + P ITI E P+ + V + A+ +
Sbjct: 1601 VSATDLGPERRKSTTELTIILQGL---DGPVFTQPKYITILKEGEPIGTNVISIEAA-SP 1656
Query: 1880 SGCNARLTFNITAGNRE-----RAFFINATTGIVTVNRPLDRERIPEYKL--TISVKDNP 1932
G A + + I + E R F I TGI+ LDRE+ L +++ +
Sbjct: 1657 RGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKST 1716
Query: 1933 ENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQ 1992
PR R + + I L D NDN P+F V EN G+ + L A+DAD+
Sbjct: 1717 AFPRTQRAEVE---ITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLT----AMDADE 1769
Query: 1993 DIYAVVTYQLLGAQSGLFDINSSTG--VVTVRSGVIIDREAFSPPILELLLLAEDIGLLN 2050
A+VTY ++ F I+ +G + T R +DRE S LL+ A+D GL +
Sbjct: 1770 GANALVTYTIISGADDSFRIDPESGDLIATRR----LDRERRSK--YSLLVRADD-GLQS 1822
Query: 2051 STAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEA 2110
S + IT+ D ND+ P FS + + E+ PG V + ATD+DSG+NGE+ Y +
Sbjct: 1823 SDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNE 1882
Query: 2111 GAQDR-FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIND 2169
+D F ++ +TGV + +D E Q+ Y LTV A D G + IL D+ND
Sbjct: 1883 DDEDGIFFLNPITGVFNL-TRLLDYEVQQYYILTVRAEDGGGQFTTIRVYFNIL--DVND 1939
Query: 2170 SRPEFLNPIQTVSVLESAEPGT--VIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQ 2227
+ P F + S++E+ G+ ++ N+T D +N +L Y I +
Sbjct: 1940 NPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIAS-----------GDS 1988
Query: 2228 EDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVS--VPNAKLTVNVLD 2285
F V+ N G + V ++RE + Y + + V DLP+ S A++++ +LD
Sbjct: 1989 LGQFTVDKN-GVLKVLKALDRESQSFYNLVVQV----HDLPQIPASRFTSTAQVSIILLD 2043
Query: 2286 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2345
VNDN P F +TY I E T + A DPD G N + YTLL+ P G
Sbjct: 2044 VNDNPPTFLSPKLTY----IPENTPIDTVVFKAQATDPDSGPNSYIEYTLLN--PLGNKF 2097
Query: 2346 LEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQP 2405
+ G+V +D EEV TV A+D G P ++ V + ++DINDNNPIF Q
Sbjct: 2098 SIGTIDGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQA 2157
Query: 2406 SYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSL 2463
Y+ + E+ GT I+ V A D D G + Y + G+ +F I+ TG I V L
Sbjct: 2158 LYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPL 2217
Query: 2464 DREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEP 2523
DREK Y LT A D S R ++ V I +LD+ND P F +S +V EN
Sbjct: 2218 DREKTPTYHLTVQATDR----GSTPRTDTSTVSIVLLDINDFVPVFELSPYSVNVPEN-- 2271
Query: 2524 AGT---SVITMMATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGL-VTTQRPLQSYEKFS 2578
GT +++ ++A D D G N +L+Y L G + AF + L VT ++ E+F
Sbjct: 2272 LGTLPRTILQVVARDDDRGSNSKLSYVLFGGNEDNAFTLSASGELGVTQSLDRETKERFV 2331
Query: 2579 LTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYAT 2638
L + ATD G P L GT + V V DVNDN P F T I E+ P ++V V A+
Sbjct: 2332 LMITATDSGSPALTGTGTINVIVDDVNDNVPTFASKAYFTT--IPEDAPTGTDVLLVNAS 2389
Query: 2639 DKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQ 2698
D D N +R GN F I+P +G I T+ LDRE++ Y+L++V SD G
Sbjct: 2390 DADASKNAVIRI----IGGNSQ---FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGS 2442
Query: 2699 PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAV---D 2755
P P + + V + D++DN P F P H P TL G+ AV D
Sbjct: 2443 PEPLSSSTSVLVTVTDVNDNPPRFQHHP----------YVTHIPSPTLPGSFVFAVTVTD 2492
Query: 2756 ADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVK 2804
AD GPN+ ++Y ++ N EK FH+ P G ++ L+ E FS VK
Sbjct: 2493 ADIGPNSELHYSLSGRNSEK-FHIDPLRGAIMAAGPLNGASEVTFSVHVK 2541
Score = 969 bits (2505), Expect = 0.0
Identities = 901/2899 (31%), Positives = 1335/2899 (46%), Gaps = 222/2899 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSG-------EEASRFFAVEPDTGVVWLRQPLD 94
+ E+ G S+ Q A D D GV+G + FA+ G + L PLD
Sbjct: 902 VVENWQAGHSIFQAKAVDPDE-----GVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLD 956
Query: 95 RETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
S + +E SD GV + + V DVNDN+P F Y V + E+ PV +
Sbjct: 957 VHAGS-YQIEILASD-MGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSR 1014
Query: 151 IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDS-ARGIVTVIRELDYETTQAYQLTVNATD 209
F V A+D D GA G + Y+ + A G + + ELD E Y L V A+D
Sbjct: 1015 FFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYVLMVVASD 1074
Query: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269
+ PLS N+ +I+ DV D P+F + Y+ E G+ V ++A+D+D G
Sbjct: 1075 R-AVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNG 1133
Query: 270 GIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHG---FILTVKGTELNDDRTPS 326
+ Y+ + F L ISG +T DRE+ + G F TV T D P
Sbjct: 1134 EVRYSFEMVQPD--FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIAT---DQGIPQ 1188
Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMF 386
T ++ + DINDNAP+F Y I+E A L ++V D + G N +
Sbjct: 1189 PLKDQATVHVYMKDINDNAPKFLKDFYQATISESAA---NLTQVLRVSASDVDEGNNGLI 1245
Query: 387 EVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES--VPDHVGY 443
++ GN F I TS Q + + LDYE Y + A +S +P +
Sbjct: 1246 HYSIIKGNEERQFAIDSTSGQ------VTLIGKLDYEATPAYSLVIQAVDSGTIPLN-ST 1298
Query: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS--D 501
+ I +++ENDN P F + + + EN+ +G V +V ATD+D+G ++ Y + +
Sbjct: 1299 CTLNIDILDENDNTPSFPKSTLFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTN 1358
Query: 502 DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVLDVNDNVP 559
+ FS+ +TG I L +LD+E + L I A+D G +T V I+V D NDN P
Sbjct: 1359 NHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKDQGRPPRSSTMSVVIHVRDFNDNPP 1418
Query: 560 TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
+F ++ EN P T ++ + A D D+ N Q++Y+I+ G++F I E G
Sbjct: 1419 SFPPGDIFKSIVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTID--EVKG 1476
Query: 620 VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVP---VTIEVFDENDNPPTF-SKPA 675
I + +D E + L LTV A D P VTI V D NDN P F S+ A
Sbjct: 1477 TIYTNAEIDREFAN--LFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNA 1534
Query: 676 YFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLD 735
++ + + G+ + + A D D E I + + T F ++ SG++ S L
Sbjct: 1535 --LAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTDT-FIVDRYSGDLRVASALV 1591
Query: 736 RETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDS 795
++ Y LIV A D G + T T+ + LD P + Y L E P +
Sbjct: 1592 -PSQLIYNLIVSATDLGPERRKSTTELTIILQGLD----GPVFTQPKYITILKEGEPIGT 1646
Query: 796 DVTTVVAVDPDLGENGTLVYSI------QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHE 849
+V ++ A P E Y + + + +++ TG I+T A+LDRE
Sbjct: 1647 NVISIEAASPRGSEAPVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTA-AILDREQG---- 1701
Query: 850 AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSI 909
A L V ++ P T A V + L D+NDN P F V E I G I
Sbjct: 1702 ACLYLVDVYAIEKSTAFP--RTQRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKI 1759
Query: 910 YQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD 969
Q+ A+D DEG N LV+Y + G F I+ SG ++ T LDRER ++Y L V A D
Sbjct: 1760 MQLTAMDADEGANALVTYTIISGADD-SFRIDPESGDLIATRRLDRERRSKYSLLVRADD 1818
Query: 970 AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAE 1029
+SS + I V DVND TP F VY+ + ED V + TD+D G+N E
Sbjct: 1819 G---LQSSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGE 1875
Query: 1030 LSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVF 1089
++Y + + DG F + V LD E Y+L + A D G T V+
Sbjct: 1876 ITYIVNEDDEDGIFFLNPITGVFNLTRLLDYEVQQYYILTVRAEDGGG----QFTTIRVY 1931
Query: 1090 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNN 1149
+LDVNDN PIF +SY S+ E++P G ++L TDAD+G ++ Y I G+
Sbjct: 1932 FNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQ 1991
Query: 1150 FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPM-----RSSVRVIVYVEDINDE 1204
F + NG+L + + LDRE S + L+V+ HDL + S+ +V + + D+ND
Sbjct: 1992 FTVD-KNGVL-KVLKALDRESQSFYNLVVQV--HDLPQIPASRFTSTAQVSIILLDVNDN 2047
Query: 1205 APVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGL 1264
P F + + + E I T V QATD DSG + Y +L+ KF I G
Sbjct: 2048 PPTFLSPKLTYIP--ENTPIDTVVFKAQATDPDSGPNSYIEYTLLNPLGNKFSIGTIDGE 2105
Query: 1265 IITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILE 1324
+ LD E ++Y + V ATD+ P V + +L+ D F+ A Y+ I E
Sbjct: 2106 VRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVEINE 2165
Query: 1325 NLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDF 1384
N GT+I++V A D R+ + F+ID++TG ITV +DREK
Sbjct: 2166 NTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQE-FRIDSVTGAITVAKPLDREKTPT 2224
Query: 1385 YTLTVVADDGG--PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQR-VATV 1441
Y LTV A D G P+ D++ V I +LD ND P F+ S +V++PE+ R + V
Sbjct: 2225 YHLTVQATDRGSTPRTDTST-VSIVLLDINDFVPVFEL-SPYSVNVPENLGTLPRTILQV 2282
Query: 1442 KAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASD 1501
A D D GSN ++ + L GN AF T + GE+ V + LDRE + ++L + A+D
Sbjct: 2283 VARDDDRGSNSKLSYVLFGGNEDNAF----TLSASGELGVTQSLDRETKERFVLMITATD 2338
Query: 1502 RGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINS 1561
G+P + V + D+NDN P S Y ++ E+ GT V+ V A+D D N+
Sbjct: 2339 SGSPALTGTGTINVIVDDVNDNVPTFASK-AYFTTIPEDAPTGTDVLLVNASDADASKNA 2397
Query: 1562 VLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPT-LSATTHV 1620
V+ I GN F ++ +G+I T A DRE + Y LV D G+P LS++T V
Sbjct: 2398 VIR--IIGGNSQ--FTINPSTGQIITS-ALLDRETKDNYTLVVVCSDAGSPEPLSSSTSV 2452
Query: 1621 YVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIV 1680
VT+ D NDN P FQ Y + P + + + D D GPN + Y++ +G
Sbjct: 2453 LVTVTDVNDNPPRFQHHPYVTHIPS-PTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNS 2510
Query: 1681 NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDN 1740
F ID G I AA L+ T V D T+ T VN D
Sbjct: 2511 EKFHIDPLRGAIMAAGPLN---GASEVTFSVHVKDGGSFPKTDSTTVTVRFVNKAD---- 2563
Query: 1741 VPTFP--RDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVE 1798
FP R E F E QP + T + G + Y I G+ F I +
Sbjct: 2564 ---FPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGE--PMSYYIASGNLGNTFQIDQLT 2618
Query: 1799 GVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNI 1858
G + + + LD E I Y + I ARD G PP SS + I VLD+NDN P+ P
Sbjct: 2619 GQVSISQP--LDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFIS 2676
Query: 1859 TISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRER 1918
I EN + V A D DSG N +L + I GN E +F IN TG + RPLDRE+
Sbjct: 2677 EILENLSPRKILT-VSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREK 2735
Query: 1919 IPEYKLTI--SVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT 1976
+ Y LTI S K +P + ++I + DENDN P F++ + A V ENSP G
Sbjct: 2736 VSHYVLTIKSSDKGSPSQSTSVK-----VMINILDENDNAPRFSQ-IFSAHVPENSPLGY 2789
Query: 1977 PLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPI 2036
+T + D D I A+ Y ++ A S F IN STG + + ++RE
Sbjct: 2790 TVT----RVTTSDEDIGINAISRYSIMDA-SLPFTINPSTGDIVISRP--LNRE--DTDR 2840
Query: 2037 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2096
+ + A D G ST + I + D NDN P FS + + E G V QV ATD
Sbjct: 2841 YRIRVSAHDSGWTVST-DVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDP 2899
Query: 2097 DSGLNGELVYRIEAGAQDRFLIHLVTG------VIRVGNAT-IDREEQESYRLTVVATDR 2149
D G NG++ Y I++ ++ F I+ TG +++ N T + V ++DR
Sbjct: 2900 DEGSNGQVFYFIKSQSE-YFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDR 2958
Query: 2150 GTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD---LNPK 2206
G L VTI I D ND+ P+FL V ++ + GT + +TAID LN +
Sbjct: 2959 GKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSE 3018
Query: 2207 LEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASD 2266
+EY I N F ++ +TG + V S + +L + +T++ D +
Sbjct: 3019 VEYFISN-----------DNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGN- 3066
Query: 2267 LPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKG 2326
P S A + + V + N +TP+F ++ I E + G+ + V+A D D
Sbjct: 3067 -PPLS---SQATVHITVTEENYHTPEFSQ---SHMSATIPESHSIGSIVRTVSARDRDAA 3119
Query: 2327 LNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEI 2386
+NGL+ Y++ G + +SS G + + +DYE T+ A D G R
Sbjct: 3120 MNGLIKYSISSGNEEGIFAI-NSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGYC 3178
Query: 2387 PVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGES 2446
V + ++D+NDN+P+F Y V E+ P GT ++ + ATDADSG A+I Y++ +S
Sbjct: 3179 SVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDS 3238
Query: 2447 K-FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDC 2505
F I+P TG I LD E K Y LT A + P + R + V IQ+ N+
Sbjct: 3239 DLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDE----ERCSFATVNIQLKGTNEY 3294
Query: 2506 RPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG-VEAFHVDMDSGL 2564
P+F + + E P GT V + A+D+D G +GE+ Y + G + F ++ +G
Sbjct: 3295 VPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQ 3354
Query: 2565 VTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTM----LLVEVIDVNDNRPVFVRPPNGT 2618
+ L + E+ SL V+A + G + G + + V V+D ND P+F N
Sbjct: 3355 IYVSGILDREKEERVSLKVLAKNFGS--IRGADIDEVTVNVTVLDANDP-PIFTL--NIY 3409
Query: 2619 ILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ I E +P+ ++V V A D D + R+S+ +GN + F I +P +G I
Sbjct: 3410 SVQISEGVPIGTHVTFVSAFDSDS-IPSWSRFSYFIGSGNENGAFSI-NPQTGQITVTAE 3467
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
LDRE+ +Y+L ++A D G P + L V LEDI+DN P+ +G V
Sbjct: 3468 LDRETLPIYNLSVLAVDSGTPSATGSAS-LLVTLEDINDNGPMLT-VSEGE-------VM 3518
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNA--IVYYFIAAGNEEKNFHLQPDGCLLVLRDLDRERE 2796
E+ GTLV + + D D PN YY ++ G F L G L R++DRE+
Sbjct: 3519 ENKRPGTLVMTLQ-STDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQ- 3576
Query: 2797 AIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVA 2856
I F + + S P + T V + + D ND P + E
Sbjct: 3577 -IADFYLSVVTKDSGVPQMSSTGT-----------VHITVIDQNDNPSQSRTVEIFVNYY 3624
Query: 2857 TDAKVGSELIQVLALDADI 2875
+ G L V D D+
Sbjct: 3625 GNLFPGGILGSVKPQDPDV 3643
Score = 927 bits (2397), Expect = 0.0
Identities = 780/2504 (31%), Positives = 1211/2504 (48%), Gaps = 185/2504 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ E+ +G V+ + A D D N L + ++G F++ P+TG ++L + LD ET+
Sbjct: 1324 VLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQ 1383
Query: 99 SEFTVEFSVSDHQG----VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
S + + + D QG T V I V D NDN P+F I EN P+GT + V
Sbjct: 1384 SLYKLNITAKD-QGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISV 1442
Query: 155 NATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
A DPD G + Y+ P F ID +G + E+D E ++LTV A DQ
Sbjct: 1443 TAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQ- 1501
Query: 212 KTRPLST----LANLAIIITDVQDMDPIFINLPYSTNIYEHSPP---GTTVRIITAIDQD 264
P+ T L N+ I++TD+ D P+FI S N P G+ + I A D D
Sbjct: 1502 -AVPIETRRYALKNVTILVTDLNDNVPMFI----SQNALAADPSAVIGSVLTTIMAADPD 1556
Query: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
+G I Y I++G+T++ F +D SG L + L +Y+ L V T+L +R
Sbjct: 1557 EGANGEIEYEIINGDTDT-FIVDRYSGDLRVASALVPSQLIYN----LIVSATDLGPERR 1611
Query: 325 PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
S TT I++ ++ P F +Y + E +G + ++ G +
Sbjct: 1612 KS----TTELTIILQGLD--GPVFTQPKYITILKEGEPIGTN----VISIEAASPRGSEA 1661
Query: 385 MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYET-VDRYDFDLFANESVP--DHV 441
E Y+V + G+ I+ A LD E Y D++A E
Sbjct: 1662 PVEYYIVSVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRT 1721
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY-FFS 500
A+V+ITL + NDN P+F + ++++ EN+ G+ ++ + A D D G V+Y S
Sbjct: 1722 QRAEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIIS 1781
Query: 501 DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPT 560
D F +D ++G ++ RLD E +++L + A D G + + R+ I V DVND+ P
Sbjct: 1782 GADDSFRIDPESGDLIATRRLDRERRSKYSLLVRA-DDGLQSSDMRINITVSDVNDHTPK 1840
Query: 561 FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
F + Y + E+ + + + ATD+DS N +ITY + G +F L GV
Sbjct: 1841 FSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFF---LNPITGV 1897
Query: 621 ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 680
+++R LDYE LTV A D G +T+ V + D NDNPP FS +Y S+
Sbjct: 1898 FNLTRLLDYEV--QQYYILTVRAEDGGGQ--FTTIRVYFNILDVNDNPPIFSLNSYSTSL 1953
Query: 681 VENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKS 740
+EN+ G+TVL N TD D I S + QF ++ ++G + LDRE++S
Sbjct: 1954 MENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVD-KNGVLKVLKALDRESQS 2012
Query: 741 EYILIVRAVD-GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTT 799
Y L+V+ D + ++ T A V+I LLD+NDN PT+ +P + E TP D+ V
Sbjct: 2013 FYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFL-SPKLTYIPENTPIDTVVFK 2071
Query: 800 VVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIV 857
A DPD G N + Y++ P NKF S+ + G++R T LDRE + +
Sbjct: 2072 AQATDPDSGPNSYIEYTLLNPLGNKF-SIGTIDGEVRLT-GELDREEVSNYT------LT 2123
Query: 858 VSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDL 917
V TD G+P L +SS V V +LD+NDN+P F + E+ E G I QV A D
Sbjct: 2124 VVATDKGQPSL--SSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADG 2181
Query: 918 DEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSS 977
DEG NG V Y + G +F I+S +G + LDRE+ Y L V A+D G+ ++
Sbjct: 2182 DEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTD 2241
Query: 978 TSTLTIHVLDVNDETPTFFPAVYNVSVSEDV---PREFRVVWLNCTDNDVGLNAELSYFI 1034
TST++I +LD+ND P F + Y+V+V E++ PR ++ + D+D G N++LSY +
Sbjct: 2242 TSTVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRT--ILQVVARDDDRGSNSKLSYVL 2299
Query: 1035 TGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLD 1094
GGN D F++ + LDRET ++L++ A D+G TGT T+ V V D
Sbjct: 2300 FGGNEDNAFTLS-ASGELGVTQSLDRETKERFVLMITATDSGSPAL--TGTGTINVIVDD 2356
Query: 1095 VNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHV 1154
VNDN P F +Y ++PED P G +L + A+DAD + + RI+ GN + F I+
Sbjct: 2357 VNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVI--RIIGGN--SQFTINP 2412
Query: 1155 SNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG---PMRSSVRVIVYVEDINDEAPVFTQQ 1211
S G ++ LDRE ++ L+V D G P+ SS V+V V D+ND P F
Sbjct: 2413 STGQIITSAL-LDRETKDNYTLVVVC--SDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHH 2469
Query: 1212 QYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYL 1271
Y T G+ V V TD D G ++Y + KF ID G I+ L
Sbjct: 2470 PYVTHIPSPTLP-GSFVFAVTVTDADIGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGPL 2528
Query: 1272 DYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD-EAVQFSNASYEAAILENLALGT 1330
+ ++ ++ ++V P + +V + +N+ D V+ ++ EN + +
Sbjct: 2529 NGASEVTFSVHVKDGGSFPKTDS--TTVTVRFVNKADFPKVRAKEQTF--MFPENQPVSS 2584
Query: 1331 EIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVV 1390
+ + S+ Y S F+ID +TG +++ +D EK Y + +
Sbjct: 2585 LVTTITGSSLRGEPMSYY----IASGNLGNTFQIDQLTGQVSISQPLDFEKIQKYVVWIE 2640
Query: 1391 ADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAG 1449
A DGG P S K+ ITVLD NDN+P F D +S + +++ TV A D D+G
Sbjct: 2641 ARDGGFPPFSSYEKLDITVLDVNDNAPIFK--EDPFISEILENLSPRKILTVSAMDKDSG 2698
Query: 1450 SNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKK 1509
NGQ+ + + +GN+ +F I N + GE+ RPLDRE++ HY+L + +SD+G+P +
Sbjct: 2699 PNGQLDYEIVNGNMENSFSI---NHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQST 2755
Query: 1510 DHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE 1569
+ + ILD NDN P F +V N +G V +V +D DIGIN++ Y I +
Sbjct: 2756 SVKVMINILDENDNAPRFSQIFSAHVPENSPLG--YTVTRVTTSDEDIGINAISRYSIMD 2813
Query: 1570 GNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEND 1629
+ + F ++ +G+I P +RE Y + + D G + +T V + + D ND
Sbjct: 2814 AS--LPFTINPSTGDIVIS-RPLNREDTDRYRIRVSAHDSGW---TVSTDVTIFVTDIND 2867
Query: 1630 NAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHM 1689
NAP F + Y + E + + + + + A D DEG NG V Y I + + FRI+
Sbjct: 2868 NAPRFSRTSYYLDCPELTE-IGSKVTQVFATDPDEGSNGQVFYFIKSQS--EYFRINATT 2924
Query: 1690 GVITAAKELDYE-------ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVP 1742
G I + L Y+ ++ R++ IVT++D+ L S TTV +N+ D NDN P
Sbjct: 2925 GEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRG---KPSLISETTVTINIVDSNDNAP 2981
Query: 1743 TFPRD-YEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVL 1801
F + Y P + D+D G N +VEY I + + LG+F + G +
Sbjct: 2982 QFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWI 3041
Query: 1802 RVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITIS 1861
V + D F +T+ A+D+G PPLSS V I V + N + P M+ TI
Sbjct: 3042 SVASSLISDLNQNFF--ITVTAKDKGNPPLSSQATVHITVTEENYHTPEFSQSHMSATIP 3099
Query: 1862 ENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPE 1921
E+ + S V V A D D+ N + ++I++GN E F IN++TGI+T+ + LD E +
Sbjct: 3100 ESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQK 3159
Query: 1922 YKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVL 1981
+++TIS D +AR Y + + + D NDN P+F Y V+EN+P+GT + L
Sbjct: 3160 HEMTISAID---GGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHL 3216
Query: 1982 NGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
N A DAD AV+ Y + + S LF I+ +TGV+T + +D E L +
Sbjct: 3217 N----ATDADSGTNAVIAYTVQSSDSDLFVIDPNTGVITTQG--FLDFETKQSYHLTVKA 3270
Query: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
S A + I + N+ P F + E P G V +V A+D D G +
Sbjct: 3271 FNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTD 3330
Query: 2102 GELVYRIEAGAQDR-FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV 2160
GE+ Y I ++ + F I+ TG I V + +DRE++E L V+A + G++ + V
Sbjct: 3331 GEVHYLIFGNSRKKGFQINKKTGQIYV-SGILDREKEERVSLKVLAKNFGSIRGADIDEV 3389
Query: 2161 TILID--DINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP---KLEYHIVGIV 2215
T+ + D ND P F I +V + E GT + ++A D D P + Y I
Sbjct: 3390 TVNVTVLDANDP-PIFTLNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGS-- 3446
Query: 2216 AKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2275
N+ AF++N TG + V + ++RE + Y +++ +D+ + +
Sbjct: 3447 ---------GNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVDSGT-----PSATG 3492
Query: 2276 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLN-GLVTYT 2334
+A L V + D+NDN P +T ++E PGT ++ + + DPD N G TY
Sbjct: 3493 SASLLVTLEDINDNGPM-----LTVSEGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYY 3547
Query: 2335 LLDLVP-PGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
LL P Y L S+AG + R +D E++ +V D+G P ++ V++ ++
Sbjct: 3548 LLSTGPATSYFSL--STAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVI 3605
Query: 2394 DINDNNPIFDQPSYQEAV------FEDVPVGTIILTVTATDADSGNFALIEYSLGDG-ES 2446
D NDN PS V + ++ G I+ +V D D SL G S
Sbjct: 3606 DQNDN------PSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDV--LDSFHCSLTSGVTS 3657
Query: 2447 KFAINPTTGDIYVLSSLDREKKDHYILTALAKDN-PGDVASNRR 2489
F+I T D L+S R + LT L+ D V SN R
Sbjct: 3658 LFSIPGGTCD---LNSQPRSTDGTFDLTVLSNDGVHSTVTSNIR 3698
Score = 865 bits (2236), Expect = 0.0
Identities = 778/2653 (29%), Positives = 1227/2653 (46%), Gaps = 214/2653 (8%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPD----- 83
P F + + Y E+ GS V ++ A D D FG +GE F V+PD
Sbjct: 1098 PLFNSTNYTFYF--EEEQRAGSFVGKVSAVDKD-----FGPNGEVRYSFEMVQPDFELHA 1150
Query: 84 -TGVVWLRQPLDRET--KSEFTVEFS---VSDHQGVIT-----RKVNIQVGDVNDNAPTF 132
+G + DRE+ + T FS ++ QG+ V++ + D+NDNAP F
Sbjct: 1151 ISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKF 1210
Query: 133 HNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVI 190
Y I E+ T + V+A+D D G G + YS ++ FAIDS G VT+I
Sbjct: 1211 LKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLI 1270
Query: 191 RELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP 250
+LDYE T AY L + A D T PL++ L I I D D P F ++ E+
Sbjct: 1271 GKLDYEATPAYSLVIQAVDSG-TIPLNSTCTLNIDILDENDNTPSFPKSTLFVDVLENMR 1329
Query: 251 PGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGF 310
G V +TA D D G + Y+I N + F++ +G + L LD E
Sbjct: 1330 IGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQS----- 1384
Query: 311 ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370
+ + T + R P +T++ ++ D NDN P F + +I E +G ++
Sbjct: 1385 LYKLNITAKDQGRPPRSSTMSVVIHVR--DFNDNPPSFPPGDIFKSIVENIPIGTSV--- 1439
Query: 371 IQVVDKDENLGLNSMFEVYLVGN--NSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD 428
I V D + +N ++ +HF I V+G I +D E + ++
Sbjct: 1440 ISVTAHDPDADINGQLSYTIIQQMPRGNHFTID--EVKGT----IYTNAEIDREFANLFE 1493
Query: 429 FDLFANE-SVPDHVG-YAKVKITLI--NENDNRPIFSQPLYNISLYENVTVGTSVLTVLA 484
+ AN+ +VP YA +T++ + NDN P+F ++ + +G+ + T++A
Sbjct: 1494 LTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQ-NALAADPSAVIGSVLTTIMA 1552
Query: 485 TDNDAGTFGEVSY-FFSDDPDRFSLDKDTG-LIMLIARLDYELIQRFTLTIIARDGGGEE 542
D D G GE+ Y + D D F +D+ +G L + A + +LI + L + A D G E
Sbjct: 1553 ADPDEGANGEIEYEIINGDTDTFIVDRYSGDLRVASALVPSQLI--YNLIVSATDLGPER 1610
Query: 543 TTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQ--ITYSI 600
+ ++ + P F + Y+ L+E EP T ++ + A SP ++ + Y I
Sbjct: 1611 RKSTTELTIILQGLDGPVFTQPKYITILKEGEPIGTNVISIEAA---SPRGSEAPVEYYI 1667
Query: 601 VSA----SAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT-VMAMDAGNP-PLNST 654
VS G F I + G +I + LD EQ +YL V A++ P
Sbjct: 1668 VSVRCEEKTVGRLFTIGRHTG--IIQTAAILDREQ--GACLYLVDVYAIEKSTAFPRTQR 1723
Query: 655 VPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE 714
V I + D NDNPP F ++V ENI G+ ++ L A D D E + Y++
Sbjct: 1724 AEVEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDAD---EGANALVTYTII 1780
Query: 715 GSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIN 772
FRI+ SG++ T LDRE +S+Y L+VRA DG + + +NIT+ D+N
Sbjct: 1781 SGADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQSSDMR-----INITVSDVN 1835
Query: 773 DNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTT 830
D+ P + Y ++ E T P S V ++A D D G NG + Y + ++ + LN T
Sbjct: 1836 DHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPIT 1895
Query: 831 GKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF 890
G T +LD +E + + V D G ++ V+ N+LD+NDN P F
Sbjct: 1896 GVFNLTR-LLD------YEVQQYYILTVRAEDGGGQ----FTTIRVYFNILDVNDNPPIF 1944
Query: 891 QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTT 950
+ ++E +P G ++ D D+G+N ++Y + G F ++ + GV+
Sbjct: 1945 SLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTVDKN-GVLKVL 2003
Query: 951 TELDRERIAEYQLRVVASDAGTPTKS---STSTLTIHVLDVNDETPTFFPAVYNVSVSED 1007
LDRE + Y L V D S ST+ ++I +LDVND PTF + E+
Sbjct: 2004 KALDRESQSFYNLVVQVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPEN 2062
Query: 1008 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1067
P + V TD D G N+ + Y + + KFS+G D VR LDRE + Y
Sbjct: 2063 TPIDTVVFKAQATDPDSGPNSYIEYTLLNP-LGNKFSIGTIDGEVRLTGELDREEVSNYT 2121
Query: 1068 LILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKAT 1127
L + A D G + + V V VLD+NDN PIF Q+ Y+ + E+ G I+Q+ A
Sbjct: 2122 LTVVATDKGQPSL--SSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAA 2179
Query: 1128 DADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGP 1187
D DEG G+V Y I++GN FRI G + +PLDRE+ ++ L V+A + P
Sbjct: 2180 DGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVA-KPLDREKTPTYHLTVQATDRGSTP 2238
Query: 1188 MRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG-IGTSVIVVQATDRDSGDGGLVNY 1246
+ V + + DIND PVF YS + + E G + +++ V A D D G ++Y
Sbjct: 2239 RTDTSTVSIVLLDINDFVPVFELSPYS-VNVPENLGTLPRTILQVVARDDDRGSNSKLSY 2297
Query: 1247 RILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNE 1306
+ G E ++G + LD ETK +++ ++ATD P G ++ + + +
Sbjct: 2298 VLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDV 2357
Query: 1307 LDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA 1366
D F++ +Y I E+ GT+++ V A D R S F I+
Sbjct: 2358 NDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIRIIGGNSQ-----FTINP 2412
Query: 1367 ITGVITVQGLVDREKGDFYTLTVVADDGGPK--VDSTVKVYITVLDENDNSPRFDFTSDS 1424
TG I L+DRE D YTL VV D G + S+ V +TV D NDN PRF
Sbjct: 2413 STGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQH-HPY 2471
Query: 1425 AVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARP 1484
IP G V V D D G N ++ +SL SG + F I G + A P
Sbjct: 2472 VTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEKFHIDPLR---GAIMAAGP 2527
Query: 1485 LDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGG 1544
L+ V D G+ P+ + V ++ D P V + N+ V
Sbjct: 2528 LNGAS--EVTFSVHVKDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSL 2585
Query: 1545 TAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVA 1604
+ + + +SYYI GN F++D+++G+++ P D E+ Y +
Sbjct: 2586 VTTITGSSLRGE-----PMSYYIASGNLGNTFQIDQLTGQVSISQ-PLDFEKIQKYVVWI 2639
Query: 1605 TVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHY--EVLLDEGPDTLNTSLITIQALDL 1662
D G P S+ + +T++D NDNAP+F++ + E+L + P ++T+ A+D
Sbjct: 2640 EARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENLSP----RKILTVSAMDK 2695
Query: 1663 DEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYE-ISHGRYTLIVTATDQCPILS 1721
D GPNG + Y IV GN+ N+F I+ G I + + LD E +SH Y L + ++D+ S
Sbjct: 2696 DSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSH--YVLTIKSSDKG---S 2750
Query: 1722 HRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVE 1780
+++ V++N+ D NDN P F + + V E P G V D D G N
Sbjct: 2751 PSQSTSVKVMINILDENDNAPRFSQIFSA--HVPENSPLGYTVTRVTTSDEDIGINAISR 2808
Query: 1781 YSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIR 1840
YSIMD F I+P G + + + L+RE Y + + A D G + V I
Sbjct: 2809 YSIMDASL--PFTINPSTGDIVISRP--LNREDTDRYRIRVSAHDSGWTVSTD---VTIF 2861
Query: 1841 VLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFF 1900
V DINDN P + E + + S V V A+D D G N ++ + I + + F
Sbjct: 2862 VTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSNGQVFYFIKS--QSEYFR 2919
Query: 1901 INATTGIVTVNRPLDRERIP--------EYKLTISVKDNPENPRIARRDYDLLLIFLSDE 1952
INATTG + + L + + + ++ D + I+ + ++ D
Sbjct: 2920 INATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRGKPSLISETTVTINIV---DS 2976
Query: 1953 NDNHPLFTKSTYQAEVMENSPAGTPL---TVLNGPILALDADQDIYAVVTYQLLGAQSGL 2009
NDN P F KS Y V +N GT L T ++ L+++ + + L G
Sbjct: 2977 NDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEVEYFISNDNHL-----GK 3031
Query: 2010 FDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL--LNSTAHLLITILDDNDNRP 2067
F +++ TG ++V S +I D + + A+D G L+S A + IT+ ++N + P
Sbjct: 3032 FKLDNDTGWISVASSLISDLNQN----FFITVTAKDKGNPPLSSQATVHITVTEENYHTP 3087
Query: 2068 TFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR-FLIHLVTGVIR 2126
FS + ++ + E+ G V V+A D D+ +NG + Y I +G ++ F I+ TG++
Sbjct: 3088 EFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILT 3147
Query: 2127 VGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLES 2186
+ A +D E + + +T+ A D G V +G VT+ + D+ND+ P FL+ +VLE+
Sbjct: 3148 LAKA-LDYELCQKHEMTISAIDGGWVARTGYCSVTVNVIDVNDNSPVFLSDDYFPTVLEN 3206
Query: 2187 AEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKS 2244
A GT + ++ A D D N + Y + + D F ++ NTG + +
Sbjct: 3207 APSGTTVIHLNATDADSGTNAVIAYTVQS------------SDSDLFVIDPNTGVITTQG 3254
Query: 2245 PMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMER 2304
++ E +Y +T+ N D S + N +L N+ P+F YY E
Sbjct: 3255 FLDFETKQSYHLTVKAF-NVPDEERCSFATVNIQLK----GTNEYVPRF--VSKLYYFE- 3306
Query: 2305 ILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEE 2364
I E A GT + V A D D G +G V Y + Q+ + G++ + +D E+
Sbjct: 3307 ISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQI-NKKTGQIYVSGILDREK 3365
Query: 2365 VHWLNFTVRASDNGSPPRAA--EIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIIL 2422
++ V A + GS A E+ V + ++D ND PIF Y + E VP+GT +
Sbjct: 3366 EERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDP-PIFTLNIYSVQISEGVPIGTHVT 3424
Query: 2423 TVTATDADS-GNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKD 2479
V+A D+DS +++ Y +G G F+INP TG I V + LDRE Y L+ LA D
Sbjct: 3425 FVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVD 3484
Query: 2480 NPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEG 2539
+ A+ S +++ + D+ND P + + V EN+ GT V+T+ +TD D
Sbjct: 3485 SGTPSATG----SASLLVTLEDINDNGPMLTVSE--GEVMENKRPGTLVMTLQSTDPDLP 3538
Query: 2540 PN-GELTYSL--EGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGT 2594
PN G TY L GP F + +G+++T R + + F L+VV D G P + T
Sbjct: 3539 PNQGPFTYYLLSTGPATSYFSLST-AGVLSTTREIDREQIADFYLSVVTKDSGVPQMSST 3597
Query: 2595 TMLLVEVIDVNDN 2607
+ + VID NDN
Sbjct: 3598 GTVHITVIDQNDN 3610
Score = 593 bits (1528), Expect = e-168
Identities = 520/1719 (30%), Positives = 807/1719 (46%), Gaps = 151/1719 (8%)
Query: 1249 LSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD 1308
LS + F I+ STG + T + +D E+ S ++N+ AP + V + + + D
Sbjct: 74 LSESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAPTYPT---EVRVLVRDLND 130
Query: 1309 EAVQFSNASYEAAILENLALGTEIVRVQAYSID-NLNQITYRFNAYTSTQAKALFKIDAI 1367
A F + S E+ + G +++ A D N + +R F++D
Sbjct: 131 NAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDIT 190
Query: 1368 TGV--------ITVQGLVDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRF 1418
+ +G +DRE Y L V V D G PK ++V +TV D NDN P F
Sbjct: 191 LNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVF 250
Query: 1419 DFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGE 1478
+S +PED VG V V A D D G+N + + L + T G
Sbjct: 251 G-SSHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPET-----GL 304
Query: 1479 VFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF----GYN 1534
+ V PLD E Y L V A DRG P + +LD+NDN PV++ +
Sbjct: 305 ITVREPLDFEARRQYSLTVQAMDRGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRY 364
Query: 1535 VSVNENVGGGTAVVQVRATDRDI-GINSVLSYYITEGNKDMAFRMD--RISGEIATRPAP 1591
SV+EN GT V + TD D N +S I GN+ F + ++ + A
Sbjct: 365 ASVDENAQVGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVAS 424
Query: 1592 P-DRERQSFYHLVATVEDE-GTP------TLSATTHVYVTIVDENDNAPMFQQPHYEV-L 1642
DRER Y+L +V D G P S+ + + + D ND+ P+F Q Y V L
Sbjct: 425 ALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNL 484
Query: 1643 LDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKE--LDY 1700
+E P S I A D D G N + Y+IV+GN + F I H G++T LD
Sbjct: 485 SEEAPPGSYVS--GISATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDR 542
Query: 1701 EISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP- 1759
E++ + L ++A DQ H S ++V + D+ND P F + V E P
Sbjct: 543 ELA-SQIVLNISARDQGV---HPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPT 598
Query: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDGDP-LGEFVISPVEGVLRVRKDVELDRETIAFYN 1818
G + A D D G NG V +S+ + + F + PV G R+ LDRE AFY+
Sbjct: 599 GTELLMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSG--RLSTISSLDREEQAFYS 656
Query: 1819 LTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDA 1878
L + A D G PP SS + + +LDINDN PV + I EN P S++ V A+D
Sbjct: 657 LLVLATDLGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDP 716
Query: 1879 DSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD--NPENPR 1936
D G N + ++I+AG+R R F +NA +G+++ LDRE Y+L I D N ++P
Sbjct: 717 DLGTNGTVKYSISAGDRSR-FQVNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPN 775
Query: 1937 IARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYA 1996
A ++ I + D DN P+F++ Y V EN G + ++ + L+++ Y
Sbjct: 776 QA-----IVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMDLNSNIS-YL 829
Query: 1997 VVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLL 2056
+ T G Q G+F IN TG +T + +IDRE S +L ++A G + +
Sbjct: 830 ITT----GDQKGMFAINQVTGQLTTAN--VIDREEQS--FYQLKVVASG-GTVTGDTMVN 880
Query: 2057 ITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRF 2116
IT+ D NDN P F A +V+++EN G S+ Q A D D G+NG ++Y ++ ++ F
Sbjct: 881 ITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLF 940
Query: 2117 LIHLVTGVIRV-GNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFL 2175
I+ G I + G + SY++ ++A+D G LS + I+T+ + D+ND+ P F
Sbjct: 941 AINEKNGTISLLGPLDV---HAGSYQIEILASDMGVPQLSSSVILTVYVHDVNDNSPVFD 997
Query: 2176 NPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
V++ ES + + A D D E I +A+ +T DAF +
Sbjct: 998 QLSYEVTLSESEPVNSRFFKVQASDKDSGANGE--IAYTIAEGNTG-------DAFGI-F 1047
Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKP 2295
G + +KS ++REL Y + + D A + +V+V TV + DVNDN P F
Sbjct: 1048 PDGQLYIKSELDRELQDRYVLMVVASDRAVEPLSATVNV-----TVILEDVNDNRPLFNS 1102
Query: 2296 FGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355
T+Y E E G+ + V+AVD D G NG V Y+ ++V P + + +G++
Sbjct: 1103 TNYTFYFE---EEQRAGSFVGKVSAVDKDFGPNGEVRYSF-EMVQPDFEL--HAISGEIT 1156
Query: 2356 ANRTVDYEEVHW------LNFTVRASDNGSP-PRAAEIPVYLEIVDINDNNPIFDQPSYQ 2408
D E + +FTV A+D G P P + V++ + DINDN P F + YQ
Sbjct: 1157 NTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQ 1216
Query: 2409 EAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDRE 2466
+ E T +L V+A+D D GN LI YS+ G+ E +FAI+ T+G + ++ LD E
Sbjct: 1217 ATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYE 1276
Query: 2467 KKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGT 2526
Y L A D+ G + N ++ + I +LD ND P F K V EN G
Sbjct: 1277 ATPAYSLVIQAVDS-GTIPLN---STCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGE 1332
Query: 2527 SVITMMATDQDEGPNGELTYSLEGPGVEA-FHVDMDSGLVTTQRPL--QSYEKFSLTVVA 2583
V ++ ATD D G N +L YS+ G F + ++G + + L ++ + L + A
Sbjct: 1333 LVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITA 1392
Query: 2584 TDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEG 2643
D G PP T +++ V D NDN P F PP I E IP+ ++V V A D D
Sbjct: 1393 KDQGRPPRSSTMSVVIHVRDFNDNPPSF--PPGDIFKSIVENIPIGTSVISVTAHDPDAD 1450
Query: 2644 LNGAVRYSFLKTA--GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVP 2701
+NG + Y+ ++ GN F ID + G I T +DRE ++ L + A+D Q VP
Sbjct: 1451 INGQLSYTIIQQMPRGNH----FTIDEVKGTIYTNAEIDREFANLFELTVKAND--QAVP 1504
Query: 2702 YET----MQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDAD 2757
ET ++ + + + D++DN P+F+ L + G+++ + A D D
Sbjct: 1505 IETRRYALKNVTILVTDLNDNVPMFI-------SQNALAADPSAVIGSVLTTIMAA-DPD 1556
Query: 2758 EGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGP 2817
EG N + Y I G+ + + G L V L + I++ IV A+ P R
Sbjct: 1557 EGANGEIEYEIINGDTDTFIVDRYSGDLRVASALVPS-QLIYNLIVSATD---LGPERRK 1612
Query: 2818 SPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGN 2877
S T E+ ++L+ ++ P FT+ +Y + +G+ +I + A G+
Sbjct: 1613 STT----------ELTIILQGLDG--PVFTQPKYITILKEGEPIGTNVISIEAASPR-GS 1659
Query: 2878 NSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRT 2916
+ V Y I+++ + + VG++FT+G GI++T
Sbjct: 1660 EAPVEYYIVSVRC------EEKTVGRLFTIGRHTGIIQT 1692
Score = 391 bits (1005), Expect = e-108
Identities = 333/1096 (30%), Positives = 521/1096 (47%), Gaps = 66/1096 (6%)
Query: 25 VNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDT 84
VN+ F + + E+ PV S VT + + +P+ + ++ F ++ T
Sbjct: 2559 VNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLT 2618
Query: 85 GVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRI 141
G V + QPLD E ++ V D K++I V DVNDNAP F P+ I
Sbjct: 2619 GQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEI 2678
Query: 142 PENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQ 199
EN I V+A D D G G + Y + F+I+ A G + +R LD E
Sbjct: 2679 LENLS-PRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVS 2737
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
Y LT+ ++D+ ST + I I D D P F + +S ++ E+SP G TV +T
Sbjct: 2738 HYVLTIKSSDKGSPSQ-STSVKVMINILDENDNAPRFSQI-FSAHVPENSPLGYTVTRVT 2795
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
D+D G Y+I+ + F ++ +G + ++ L+RE+ + + + V +
Sbjct: 2796 TSDEDIGINAISRYSIMDASLP--FTINPSTGDIVISRPLNRED---TDRYRIRVSAHD- 2849
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
S TV+T I V DINDNAP F+ + Y + EL ++G + QV D +
Sbjct: 2850 ------SGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKV---TQVFATDPD 2900
Query: 380 LGLNSMFEVYLVGNNSHHFIISPTS--VQGKADIRIRVAIPLDYETVDRYDFDLFANE-S 436
G N Y + + S +F I+ T+ + K ++ + ++R+ F + +++
Sbjct: 2901 EGSNGQV-FYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDRG 2959
Query: 437 VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN-DAGTFGEV 495
P + V I +++ NDN P F + Y + +NV VGT ++ V A D+ D G EV
Sbjct: 2960 KPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSEV 3019
Query: 496 SYFFSDDP--DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGR--VRINV 551
YF S+D +F LD DTG I + + L +L Q F +T+ A+D G + + V I V
Sbjct: 3020 EYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHITV 3079
Query: 552 LDVNDNVPTFQKDAYVGALRENEPSVTQLVR-LRATDEDSPPNNQITYSIVSASAFGSYF 610
+ N + P F + +++ A S+ +VR + A D D+ N I YSI S + G +
Sbjct: 3080 TEENYHTPEFSQ-SHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIF- 3137
Query: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT 670
++ G++++++ LDYE +T+ A+D G VT+ V D NDN P
Sbjct: 3138 --AINSSTGILTLAKALDYELCQKH--EMTISAIDGGWVARTGYCSVTVNVIDVNDNSPV 3193
Query: 671 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-YSLEGSTQ--FRINARSGE 727
F YF +V+EN +G TV+ LNATD D G ++I Y+++ S F I+ +G
Sbjct: 3194 FLSDDYFPTVLENAPSGTTVIHLNATDADS----GTNAVIAYTVQSSDSDLFVIDPNTGV 3249
Query: 728 ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINL 787
ITT LD ETK Y L V+A + V ++ ATVNI L N+ P + YY +
Sbjct: 3250 ITTQGFLDFETKQSYHLTVKAFN--VPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEI 3307
Query: 788 VEMTPPDSDVTTVVAVDPDLGENGTLVYSI--QPPNKFYSLNSTTGKIRTTHAMLDRENP 845
E P + V V A D DLG +G + Y I K + +N TG+I + +LDRE
Sbjct: 3308 SEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVS-GILDREKE 3366
Query: 846 DPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
+ +++ K S+ TV V +LD ND P F + ++ EG+P
Sbjct: 3367 ERVSLKVLAKNFGSIRGAD------IDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPI 3419
Query: 906 GVSIYQVVAIDLDEGLN-GLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLR 964
G + V A D D + SY + G F IN +G + T ELDRE + Y L
Sbjct: 3420 GTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLS 3479
Query: 965 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDV 1024
V+A D+GTP+ + +++L + + D+ND P V V E+ V+ L TD D+
Sbjct: 3480 VLAVDSGTPSATGSASLLVTLEDINDNGPML--TVSEGEVMENKRPGTLVMTLQSTDPDL 3537
Query: 1025 GLNAE--LSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRH 1082
N Y ++ G FS+ V+ T +DRE A + L + D+G +
Sbjct: 3538 PPNQGPFTYYLLSTGPATSYFSLS-TAGVLSTTREIDREQIADFYLSVVTKDSGV--PQM 3594
Query: 1083 TGTATVFVTVLDVNDN 1098
+ T TV +TV+D NDN
Sbjct: 3595 SSTGTVHITVIDQNDN 3610
Score = 239 bits (609), Expect = 4e-62
Identities = 226/745 (30%), Positives = 329/745 (44%), Gaps = 93/745 (12%)
Query: 2177 PIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNIN 2236
P Q VLE PGT++ I P Y + FA+N +
Sbjct: 45 PRQVFQVLEEQPPGTLVGTIQT-----RPGFTYRL-------------SESHALFAINSS 86
Query: 2237 TGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPF 2296
TG++ S ++RE + + + L V+ +A P ++ V V D+NDN P F
Sbjct: 87 TGALYTTSTIDRESLPSDVINLVVLSSAPTYP--------TEVRVLVRDLNDNAPVFPDP 138
Query: 2297 GITYYMERILEGATPGTTLIAVAAVDPDKGLNGLV--TYTLLDLVPPGYVQLE------- 2347
I + E ++ G +I A D D G NG+ +Y ++ G +L+
Sbjct: 139 SIVVTFK---EDSSSGRQVILDTATDSDIGSNGVDHRSYRIIRGNEAGRFRLDITLNPSG 195
Query: 2348 DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
+ + +++ +D E V D G P R + V + + DINDN P+F Y
Sbjct: 196 EGAFLHLVSKGGLDREVTPQYQLLVEVEDKGEPKRRGYLQVNVTVQDINDNPPVFGSSHY 255
Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREK 2467
Q V ED VG+ +L V A DAD G A I Y L D + F ++P TG I V LD E
Sbjct: 256 QAGVPEDAVVGSSVLQVAAADADEGTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEA 315
Query: 2468 KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP-----QFSKPQFSTSVYENE 2522
+ Y LT A D + R E +IQ+LDVND P F SV EN
Sbjct: 316 RRQYSLTVQAMDRGVPSLTGRAE----ALIQLLDVNDNDPVVKFRYFPATSRYASVDENA 371
Query: 2523 PAGTSVITMMATDQDE-GPNGELTYSLEGPGVEAFHVDMDSG--------LVTTQRPLQS 2573
GT V + TD D NG ++ + G G E H ++ S V + +
Sbjct: 372 QVGTVVALLTVTDADSPAANGNISVQILG-GNEQRHFEVQSSKVPNLSLIKVASALDRER 430
Query: 2574 YEKFSLTVVATDG-GEPP------LWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEI 2626
++LTV +D G PP L++ V D+ND+ PVF + +++ EE
Sbjct: 431 IPSYNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYR--VNLSEEA 488
Query: 2627 PLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQR--LDRESQ 2684
P S V + ATD D GLN +RYS + G +F I SGL+ T LDRE
Sbjct: 489 PPGSYVSGISATDGDSGLNANLRYSIVSGNG---LGWFHISEHSGLVTTGSSGGLDRELA 545
Query: 2685 AVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRG 2744
+ L + A D G P + L V L D++D +P+F P+ ++V E++P G
Sbjct: 546 SQIVLNISARDQGVH-PKVSYAQLVVTLLDVNDEKPVF-----SQPEGYDVSVVENAPTG 599
Query: 2745 TLVGNVTGAVDADEGPNAIVYYFI-AAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFI 2802
T + + A D D G N V + + A + ++F L P G L + LDRE +A +S +
Sbjct: 600 TEL-LMLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLL 658
Query: 2803 VKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVG 2862
V A+ S PP+ ++ + V L DIND P F +Y A + + G
Sbjct: 659 VLATDLGS--PPQS-----------SMARINVSLLDINDNSPVFYPVQYFAHIKENEPGG 705
Query: 2863 SELIQVLALDADIGNNSLVFYSILA 2887
S + V A D D+G N V YSI A
Sbjct: 706 SYITTVSATDPDLGTNGTVKYSISA 730
Score = 130 bits (326), Expect = 3e-29
Identities = 157/545 (28%), Positives = 231/545 (42%), Gaps = 64/545 (11%)
Query: 30 FFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGV 86
F ++ +F T L E+ P G++V L A D D N + + V + S F ++P+TGV
Sbjct: 3194 FLSDDYFPTVL---ENAPSGTTVIHLNATDADSGTNAVIAYTVQSSD-SDLFVIDPNTGV 3249
Query: 87 VWLRQPLDRETKSEF--TVE-FSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143
+ + LD ETK + TV+ F+V D + VNIQ+ N+ P F ++ Y I E
Sbjct: 3250 ITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVPRFVSKLYYFEISE 3309
Query: 144 NTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDSARGIVTVIRELDYETTQAY 201
P GT + V A+D DLG G V Y S+ F I+ G + V LD E +
Sbjct: 3310 AAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERV 3369
Query: 202 QLTVNATDQDKTRPLST-LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITA 260
L V A + R + + + D D PIF YS I E P GT V ++A
Sbjct: 3370 SLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSA 3428
Query: 261 IDQDKGRPRG-IGYTIVSGNTNSIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTE 318
D D Y I SGN N F+++ +G +T+ LDRE P+Y+ +
Sbjct: 3429 FDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAV----- 3483
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD- 377
D TPS AT + + + + DINDN P SE V E + G L + +Q D D
Sbjct: 3484 --DSGTPS-ATGSASLLVTLEDINDNGPMLTVSEGEVM--ENKRPG-TLVMTLQSTDPDL 3537
Query: 378 -ENLGLNSMFEVYLV--GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFAN 434
N G F YL+ G + +F +S V + +D E + + +
Sbjct: 3538 PPNQG---PFTYYLLSTGPATSYFSLSTAGV-------LSTTREIDREQIADFYLSVVTK 3587
Query: 435 ES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFG 493
+S VP V IT+I++NDN ++ Y N+ G G G
Sbjct: 3588 DSGVPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPG-------------GILG 3634
Query: 494 EVSYFFSDDPDRFSLDKDTGLIMLIA----RLDYELIQR-----FTLTIIARDGGGEETT 544
V D D F +G+ L + D R F LT+++ DG T
Sbjct: 3635 SVKPQDPDVLDSFHCSLTSGVTSLFSIPGGTCDLNSQPRSTDGTFDLTVLSNDGVHSTVT 3694
Query: 545 GRVRI 549
+R+
Sbjct: 3695 SNIRV 3699
>gi|16507964 cadherin-like 23 isoform 2 precursor [Homo sapiens]
Length = 530
Score = 967 bits (2501), Expect = 0.0
Identities = 483/485 (99%), Positives = 484/485 (99%)
Query: 1 MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60
MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM
Sbjct: 1 MGRHVATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDM 60
Query: 61 DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI
Sbjct: 61 DNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
Query: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI
Sbjct: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
Query: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP
Sbjct: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLP 240
Query: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD
Sbjct: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
Query: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL
Sbjct: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
Query: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD
Sbjct: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
Query: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL
Sbjct: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
Query: 481 TVLAT 485
TVL +
Sbjct: 481 TVLVS 485
Score = 192 bits (488), Expect = 5e-48
Identities = 141/465 (30%), Positives = 232/465 (49%), Gaps = 42/465 (9%)
Query: 677 FVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG---STQFRINARSGEITTTSL 733
++ + E+ G++V L A D+D + +++ + G S F + +G +
Sbjct: 39 YLLISEDTPVGSSVTQLLAQDMDN------DPLVFGVSGEEASRFFAVEPDTGVVWLRQP 92
Query: 734 LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793
LDRETKSE+ V+ V +Q VNI + D+NDN PT+ + PY + + E TP
Sbjct: 93 LDRETKSEF-----TVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
Query: 794 DSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELM 853
+ + V A DPDLG G+++YS QPP++F++++S G I T LD E ++
Sbjct: 148 GTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARG-IVTVIRELDYETTQAYQ---- 202
Query: 854 RKIVVSVTDCGRP-PLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQV 912
+ V+ TD + PL ++ + + D+ D DP F NLP+ + E P G ++ +
Sbjct: 203 --LTVNATDQDKTRPLSTLANLAIIIT--DVQDMDPIFINLPYSTNIYEHSPPGTTVRII 258
Query: 913 VAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA----- 967
AID D+G + Y + G F ++ SGV+ LDRE ++
Sbjct: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
Query: 968 -SDAGTPTKSS-TSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV-VWLNCTDND- 1023
+D TP+ ++ T+T I V+D+ND P F + Y+V+++E F + +++ D D
Sbjct: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
Query: 1024 -VGLNAELSYFITGGN-----VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGP 1077
+GLN+ ++ G N + G D +R + LD ET Y L A ++ P
Sbjct: 379 NLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVP 438
Query: 1078 VGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSIL 1122
H G A V +T+++ NDNRPIF Q Y S+ E++ G S+L
Sbjct: 439 ---DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
Score = 158 bits (399), Expect = 1e-37
Identities = 148/483 (30%), Positives = 229/483 (47%), Gaps = 44/483 (9%)
Query: 1957 PLFTKSTYQAEVM--ENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ-SGLFDIN 2013
P FT + ++ E++P G+ +T L LA D D D + + + G + S F +
Sbjct: 29 PFFTNHFFDTYLLISEDTPVGSSVTQL----LAQDMDND---PLVFGVSGEEASRFFAVE 81
Query: 2014 SSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPAT 2073
TGVV +R +DRE S +E + ++ G++ T + I + D NDN PTF
Sbjct: 82 PDTGVVWLRQP--LDRETKSEFTVEFSV-SDHQGVI--TRKVNIQVGDVNDNAPTFHNQP 136
Query: 2074 LTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATID 2133
+V + EN P G + V ATD D G G ++Y + +Q F I G++ V +D
Sbjct: 137 YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTV-IRELD 194
Query: 2134 REEQESYRLTVVATDRG-TVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTV 2192
E ++Y+LTV ATD+ T PLS A + I+I D+ D P F+N + ++ E + PGT
Sbjct: 195 YETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTT 254
Query: 2193 IANITAIDHDL-NPK-LEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNREL 2250
+ ITAID D P+ + Y IV N FA++ +G + + ++RE
Sbjct: 255 VRIITAIDQDKGRPRGIGYTIVS-----------GNTNSIFALDYISGVLTLNGLLDREN 303
Query: 2251 VATYEVTLSVIDNASDLPERSVSVPNAKLTVNVL--DVNDNTPQFKPFGITYYMERILEG 2308
+ + +R+ S T N+L D+NDN P+F + Y I E
Sbjct: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS---SEYSVAITEL 360
Query: 2309 ATPGTTL---IAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTV----D 2361
A G L I V D + GLN + L+ ++ S GK V D
Sbjct: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
Query: 2362 YEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTII 2421
YE V +F + A+++ P V + +++ NDN PIF QP Y +++E+V VGT +
Sbjct: 421 YETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSV 479
Query: 2422 LTV 2424
LTV
Sbjct: 480 LTV 482
Score = 158 bits (399), Expect = 1e-37
Identities = 150/473 (31%), Positives = 226/473 (47%), Gaps = 55/473 (11%)
Query: 1111 VPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNN----FRIHVSNGLLMRGPRPL 1166
+ ED P G S+ QL A D D ++ G G F + G++ +PL
Sbjct: 42 ISEDTPVGSSVTQLLAQDMDNDP-------LVFGVSGEEASRFFAVEPDTGVVWLR-QPL 93
Query: 1167 DRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGT 1226
DRE S + +H R +V + V D+ND AP F Q YS + + E +GT
Sbjct: 94 DRETKSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYS-VRIPENTPVGT 149
Query: 1227 SVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSAT 1286
+ +V ATD D G GG V Y ++ F ID + G++ + LDYET +Y + V+AT
Sbjct: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQF-FAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
Query: 1287 DQ---APPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNL 1343
DQ P ++ IT + ++D F N Y I E+ GT + + A D
Sbjct: 209 DQDKTRPLSTLANLAIIITDVQDMDPI--FINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
Query: 1344 NQITYRFNAYT--STQAKALFKIDAITGVITVQGLVDREKGDF---YTLTV----VADDG 1394
R YT S ++F +D I+GV+T+ GL+DRE + + LTV + DD
Sbjct: 267 RP---RGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
Query: 1395 GPKVDSTVKVY--ITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT---VKAWDPDAG 1449
P D+TV I V+D NDN+P F+ +S+ +V+I E VG + V D + G
Sbjct: 324 TPS-DATVTTTFNILVIDINDNAPEFN-SSEYSVAITELAQVGFALPLFIQVVDKDENLG 381
Query: 1450 SNGQVVFSLASGNIAGAFEIVTTN---DSIGEVFVARPLDREELDHYILQVVASDRGTPP 1506
N L GN + F I T+ + + VA PLD E +D Y + A++
Sbjct: 382 LNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES---- 436
Query: 1507 RKKDHI----LQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1555
DH+ +++T+++ NDN P+ P YN+S+ ENV GT+V+ V + R
Sbjct: 437 -VPDHVGYAKVKITLINENDNRPIFSQPL-YNISLYENVTVGTSVLTVLVSPR 487
Score = 151 bits (381), Expect = 1e-35
Identities = 135/475 (28%), Positives = 216/475 (45%), Gaps = 36/475 (7%)
Query: 1632 PMFQQPHYEVLLDEGPDT-LNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMG 1690
P F ++ L DT + +S+ + A D+D P + + + F ++ G
Sbjct: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTG 85
Query: 1691 VITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEG 1750
V+ + LD E + +T+ + +D H+ T V + V D+NDN PTF +
Sbjct: 86 VVWLRQPLDRE-TKSEFTVEFSVSD------HQGVITRKVNIQVGDVNDNAPTF---HNQ 135
Query: 1751 PFEVT--EGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDV 1807
P+ V E P G ++ A D D G G V YS P F I G++ V +
Sbjct: 136 PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQP--PSQFFAIDSARGIVTVIR-- 191
Query: 1808 ELDRETIAFYNLTICARDRGMP-PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPV 1866
ELD ET Y LT+ A D+ PLS+ + I + D+ D DP+ +NLP + I E+SP
Sbjct: 192 ELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPP 251
Query: 1867 SSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRER-IPEYKLT 1925
+ V + A D D G + + I +GN F ++ +G++T+N LDRE + +
Sbjct: 252 GTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFI 311
Query: 1926 ISVKDNPENPRIARRDYDLLLIF---LSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
++VK N D + F + D NDN P F S Y + E + G L +
Sbjct: 312 LTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF- 370
Query: 1983 GPILALDADQD--IYAVVTYQLLGAQSGLFDINSST----GVVTVRSGVIIDREAFSPPI 2036
I +D D++ + ++ L+G S F I+ ++ + +R + +D E
Sbjct: 371 --IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD 428
Query: 2037 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQV 2091
+ L E + A + IT++++NDNRP FS + L EN G SVL V
Sbjct: 429 FD-LFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
Score = 149 bits (375), Expect = 6e-35
Identities = 150/498 (30%), Positives = 217/498 (43%), Gaps = 48/498 (9%)
Query: 440 HVGYAKVKITLINENDNR-PIFSQPLYNISLY--ENVTVGTSVLTVLATD--NDAGTFG- 493
HV + V I+ NR P F+ ++ L E+ VG+SV +LA D ND FG
Sbjct: 10 HVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDPLVFGV 69
Query: 494 ---EVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRIN 550
E S FF+ +PD TG++ L LD E FT+ D G T +V I
Sbjct: 70 SGEEASRFFAVEPD-------TGVVWLRQPLDRETKSEFTVEFSVSDHQGV-ITRKVNIQ 121
Query: 551 VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
V DVNDN PTF Y + EN P T + + ATD D + YS S F
Sbjct: 122 VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF---- 177
Query: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-PLNSTVPVTIEVFDENDNPP 669
++ G+++V R LDYE + LTV A D PL++ + I + D D P
Sbjct: 178 -FAIDSARGIVTVIRELDYE--TTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP 234
Query: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEIT 729
F Y ++ E+ G TV + A D D+ R G I S ++ F ++ SG +T
Sbjct: 235 IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLT 294
Query: 730 TTSLLDRET---KSEYILIVRAVDGGVGH--NQKTGIATVNITLLDINDNHPTWKDAPYY 784
LLDRE +IL V+ + + T T NI ++DINDN P + + Y
Sbjct: 295 LNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYS 354
Query: 785 INLVEMTPPDSDVTTVVAV---DPDLGENGTLVYSIQPPNKFYSLNSTT---GK--IRTT 836
+ + E+ + + V D +LG N + N + + S T GK IR
Sbjct: 355 VAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIR 414
Query: 837 HAM-LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
A+ LD E D ++ +L SV D A V + L++ NDN P F +
Sbjct: 415 VAIPLDYETVDRYDFDLFAN--ESVPD-------HVGYAKVKITLINENDNRPIFSQPLY 465
Query: 896 VAEVLEGIPAGVSIYQVV 913
+ E + G S+ V+
Sbjct: 466 NISLYENVTVGTSVLTVL 483
Score = 143 bits (360), Expect = 3e-33
Identities = 130/403 (32%), Positives = 181/403 (44%), Gaps = 30/403 (7%)
Query: 418 PLDYETVDRYDFDLFANESVPDHVGYA--KVKITLINENDNRPIFSQPLYNISLYENVTV 475
PLD ET + + SV DH G KV I + + NDN P F Y++ + EN V
Sbjct: 92 PLDRETKSEFTVEF----SVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
Query: 476 GTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIA 535
GT + V ATD D G G V Y F F++D G++ +I LDYE Q + LT+ A
Sbjct: 148 GTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
Query: 536 RDGGGE---ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP 592
D T + I + DV D P F Y + E+ P T + + A D+D
Sbjct: 208 TDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGR 267
Query: 593 NNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ--ISNGLIYLTVMAMDAGN-- 648
I Y+IVS + S F + GV++++ LD E S+G I LTV + +
Sbjct: 268 PRGIGYTIVSGNT-NSIFALDYIS--GVLTLNGLLDRENPLYSHGFI-LTVKGTELNDDR 323
Query: 649 PPLNSTVPVT--IEVFDENDNPPTFSKPAYFVSVVENIMAG-ATVLFLNATDLDRSREYG 705
P ++TV T I V D NDN P F+ Y V++ E G A LF+ D D +
Sbjct: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
Query: 706 QESIIYSL-EGSTQFRINARSGE------ITTTSLLDRETKSEYILIVRAVDGGVGHNQK 758
+Y + S F I+ S + I LD ET Y + A + H
Sbjct: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDH--- 440
Query: 759 TGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVV 801
G A V ITL++ NDN P + Y I+L E + V TV+
Sbjct: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
Score = 142 bits (357), Expect = 7e-33
Identities = 148/472 (31%), Positives = 216/472 (45%), Gaps = 41/472 (8%)
Query: 1423 DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVA 1482
D+ + I ED PVG V + A D D N +VF + SG A F V + G V++
Sbjct: 37 DTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGV-SGEEASRFFAVEPDT--GVVWLR 90
Query: 1483 RPLDREELDHYILQVVASD-RGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENV 1541
+PLDRE + ++ SD +G RK + + + D+NDN P + Y+V + EN
Sbjct: 91 QPLDRETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQ-PYSVRIPENT 145
Query: 1542 GGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYH 1601
GT + V ATD D+G + Y ++ F +D G I T D E Y
Sbjct: 146 PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARG-IVTVIRELDYETTQAYQ 202
Query: 1602 LVATVEDEG-TPTLSATTHVYVTIVDENDNAPMF-QQPHYEVLLDEGPDTLNTSLITIQA 1659
L D+ T LS ++ + I D D P+F P+ + + P +IT A
Sbjct: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT--A 260
Query: 1660 LDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYE---ISHGRYTLIVTAT-- 1714
+D D+G + Y IV+GN + F +D GV+T LD E SHG + L V T
Sbjct: 261 IDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHG-FILTVKGTEL 319
Query: 1715 --DQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE----GQPGPRVWTFLA 1768
D+ P T TTT + V DINDN P F E +TE G P +
Sbjct: 320 NDDRTP---SDATVTTTFNILVIDINDNAPEF-NSSEYSVAITELAQVGFALPLFIQVVD 375
Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISP--VEGV--LRVRKDVELDRETIAFYNLTICAR 1824
D + G N E ++ G+ F+ISP V+G +R+R + LD ET+ Y+ + A
Sbjct: 376 KDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFAN 434
Query: 1825 DRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLAS 1876
+ +P V I +++ NDN P+ NI++ EN V + V VL S
Sbjct: 435 E-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLVS 485
Score = 137 bits (345), Expect = 2e-31
Identities = 134/478 (28%), Positives = 216/478 (45%), Gaps = 55/478 (11%)
Query: 2411 VFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKF-AINPTTGDIYVLSSLDREKKD 2469
+ ED PVG+ + + A D D N L+ G+ S+F A+ P TG +++ LDRE K
Sbjct: 42 ISEDTPVGSSVTQLLAQDMD--NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI 2529
+ + D+ G + +V IQV DVND P F +S + EN P GT +
Sbjct: 100 EFTVEFSVSDHQGVITR-------KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF 152
Query: 2530 TMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGG 2587
+ ATD D G G + YS + P + F +D G+VT R L ++ + + LTV ATD
Sbjct: 153 IVNATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
Query: 2588 EP-PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNG 2646
+ PL L + + DV D P+F+ P T +I E P + V + A D+D+G
Sbjct: 212 KTRPLSTLANLAIIITDVQDMDPIFINLPYST--NIYEHSPPGTTVRIITAIDQDKGRPR 269
Query: 2647 AVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAV-YSLILVA-----SDLGQPV 2700
+ Y+ + +GN + F +D ISG++ LDRE+ + IL +D P
Sbjct: 270 GIGYTIV--SGNTN-SIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
Query: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE-- 2758
+ + DI+DN P F S +Y + + E + G + VD DE
Sbjct: 327 DATVTTTFNILVIDINDNAPEF-----NSSEYS-VAITELAQVGFALPLFIQVVDKDENL 380
Query: 2759 GPNAIVYYFIAAGNEEKNFHLQP-------DGCLLVLRDLDREREAIFSFIVKASSNRSW 2811
G N++ ++ GN +F + P D + V LD E + F + A+ +
Sbjct: 381 GLNSMFEVYL-VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES--- 436
Query: 2812 TPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVL 2869
+ + +V++ L + ND P F++ Y + + VG+ ++ VL
Sbjct: 437 -----------VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
Score = 136 bits (342), Expect = 4e-31
Identities = 140/488 (28%), Positives = 217/488 (44%), Gaps = 51/488 (10%)
Query: 2067 PTFSPATLTVHLL--ENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
P F+ +LL E+ P G SV Q+ A D D N LV+ + RF + TG
Sbjct: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
V+ + +DRE + + + +D V T V I + D+ND+ P F N +V +
Sbjct: 86 VVWL-RQPLDRETKSEFTVEFSVSDHQGVI---TRKVNIQVGDVNDNAPTFHNQPYSVRI 141
Query: 2184 LESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVK 2243
E+ GT I + A D DL G V P+Q FA++ G V V
Sbjct: 142 PENTPVGTPIFIVNATDPDLGAG------GSVLYSFQP---PSQ--FFAIDSARGIVTVI 190
Query: 2244 SPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYME 2303
++ E Y++T++ D P ++ A L + + DV D P F Y
Sbjct: 191 RELDYETTQAYQLTVNATDQDKTRPLSTL----ANLAIIITDVQDMDPIFINLP---YST 243
Query: 2304 RILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYE 2363
I E + PGTT+ + A+D DKG + YT++ L D +G + N +D E
Sbjct: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFAL-DYISGVLTLNGLLDRE 302
Query: 2364 EV---HWLNFTVRAS---DNGSPPRAAEIPVY-LEIVDINDNNPIFDQPSYQEAVFEDVP 2416
H TV+ + D+ +P A + + ++DINDN P F+ Y A+ E
Sbjct: 303 NPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQ 362
Query: 2417 VG---TIILTVTATDADSGNFALIE-YSLGDGESKFAINPTTGD------IYVLSSLDRE 2466
VG + + V D + G ++ E Y +G+ F I+PT+ I V LD E
Sbjct: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
Query: 2467 KKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGT 2526
D Y A ++ D +V I +++ ND RP FS+P ++ S+YEN GT
Sbjct: 423 TVDRYDFDLFANESVPD-----HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGT 477
Query: 2527 SVITMMAT 2534
SV+T++ +
Sbjct: 478 SVLTVLVS 485
Score = 135 bits (340), Expect = 7e-31
Identities = 134/450 (29%), Positives = 208/450 (46%), Gaps = 38/450 (8%)
Query: 1313 FSNASYEAAIL--ENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGV 1370
F+N ++ +L E+ +G+ + ++ A +DN + + + + +A F ++ TGV
Sbjct: 31 FTNHFFDTYLLISEDTPVGSSVTQLLAQDMDN-DPLVF---GVSGEEASRFFAVEPDTGV 86
Query: 1371 ITVQGLVDRE-KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIP 1429
+ ++ +DRE K +F V+D G T KV I V D NDN+P F +V IP
Sbjct: 87 VWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFH-NQPYSVRIP 142
Query: 1430 EDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREE 1489
E+ PVG + V A DPD G+ G V++S + + + + G V V R LD E
Sbjct: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS-----QFFAIDSARGIVTVIRELDYET 197
Query: 1490 LDHYILQVVASDRG-TPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVV 1548
Y L V A+D+ T P L + I D+ D P+ + Y+ ++ E+ GT V
Sbjct: 198 TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFIN-LPYSTNIYEHSPPGTTVR 256
Query: 1549 QVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYH-LVATVE 1607
+ A D+D G + Y I GN + F +D ISG + T DRE + H + TV+
Sbjct: 257 IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISG-VLTLNGLLDRENPLYSHGFILTVK 315
Query: 1608 -----DEGTPT-LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALD 1661
D+ TP+ + TT + ++D NDNAP F Y V + E + IQ +D
Sbjct: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVD 375
Query: 1662 LDE--GPNGTVTYAIVAGN----IVNTFRIDRHMGV-ITAAKELDYEISHGRYTLIVTAT 1714
DE G N +V N I++ + + I A LDYE + RY + A
Sbjct: 376 KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE-TVDRYDFDLFAN 434
Query: 1715 DQCPILSHRLTSTTTVLVNVNDINDNVPTF 1744
+ P H V + + + NDN P F
Sbjct: 435 ESVP--DH--VGYAKVKITLINENDNRPIF 460
Score = 122 bits (307), Expect = 5e-27
Identities = 130/463 (28%), Positives = 197/463 (42%), Gaps = 47/463 (10%)
Query: 1004 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETT 1063
+SED P V L D D N L + ++G F+V VV LDRET
Sbjct: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
Query: 1064 AAYMLILEAIDNGPVGKRHTGTAT--VFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSI 1121
+ + + D H G T V + V DVNDN P F Y +PE+ P G I
Sbjct: 99 SEFTVEFSVSD-------HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
Query: 1122 LQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAY 1181
+ ATD D G G V Y + F I + G ++ R LD E ++ L V A
Sbjct: 152 FIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARG-IVTVIRELDYETTQAYQLTVNAT 208
Query: 1182 NHD-LGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGD 1240
+ D P+ + + + + D+ D P+F YS + E + GT+V ++ A D+D G
Sbjct: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS-TNIYEHSPPGTTVRIITAIDQDKGR 267
Query: 1241 GGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYET---KTSYMMNVSAT----DQAPPF 1292
+ Y I+SG F +D +G++ LD E +++ V T D+ P
Sbjct: 268 PRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSD 327
Query: 1293 NQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEI-VRVQAYSIDNLNQITYRFN 1351
+ I +++ D A +F+++ Y AI E +G + + +Q D + F
Sbjct: 328 ATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFE 387
Query: 1352 AY-------------TSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKV 1398
Y TS Q KA + I V +D E D Y + A++ P
Sbjct: 388 VYLVGNNSHHFIISPTSVQGKADIR-------IRVAIPLDYETVDRYDFDLFANESVPDH 440
Query: 1399 DSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV 1441
KV IT+++ENDN P F + +S+ E+ VG V TV
Sbjct: 441 VGYAKVKITLINENDNRPIFSQPLYN-ISLYENVTVGTSVLTV 482
Score = 121 bits (304), Expect = 1e-26
Identities = 136/478 (28%), Positives = 203/478 (42%), Gaps = 50/478 (10%)
Query: 1206 PVFTQQQYSR-LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK-----FEID 1259
P FT + L + E +G+SV + A D D N ++ G G+ F ++
Sbjct: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-------NDPLVFGVSGEEASRFFAVE 81
Query: 1260 ESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYE 1319
TG++ LD ETK+ + + S +D + V I + + D A F N Y
Sbjct: 82 PDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYS 138
Query: 1320 AAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLV 1377
I EN +GT I V A D + Y F + F ID+ G++TV +
Sbjct: 139 VRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-----FFAIDSARGIVTVIREL 193
Query: 1378 DREKGDFYTLTVVADDGGPK--VDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVG 1435
D E Y LTV A D + + + I + D D P F + +I E P G
Sbjct: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIF-INLPYSTNIYEHSPPG 252
Query: 1436 QRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPL-DREE--LDH 1492
V + A D D G + +++ SGN F + D I V L DRE H
Sbjct: 253 TTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFAL----DYISGVLTLNGLLDRENPLYSH 308
Query: 1493 -YILQVVASDRGTPPRKKDHILQVT----ILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
+IL V ++ D + T ++DINDN P S Y+V++ E G A+
Sbjct: 309 GFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSS-EYSVAITELAQVGFAL 367
Query: 1548 ---VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRIS----GEIATRPAPP-DRERQSF 1599
+QV D ++G+NS+ Y+ GN F + S +I R A P D E
Sbjct: 368 PLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR 426
Query: 1600 YHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITI 1657
Y +E P V +T+++ENDN P+F QP Y + L E T+ TS++T+
Sbjct: 427 YDF-DLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENV-TVGTSVLTV 482
Score = 120 bits (300), Expect = 3e-26
Identities = 110/368 (29%), Positives = 161/368 (43%), Gaps = 28/368 (7%)
Query: 2388 VYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK 2447
V +++ D+NDN P F Y + E+ PVGT I V ATD D G + YS
Sbjct: 118 VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF 177
Query: 2448 FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
FAI+ G + V+ LD E Y LT A D + + I + DV D P
Sbjct: 178 FAIDSARGIVTVIRELDYETTQAYQLTVNATDQD---KTRPLSTLANLAIIITDVQDMDP 234
Query: 2508 QFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVT 2566
F +ST++YE+ P GT+V + A DQD+G + Y++ G F +D SG++T
Sbjct: 235 IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLT 294
Query: 2567 ------TQRPLQSYEKFSLTVVAT----DGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPN 2616
+ PL S+ F LTV T D TT + VID+NDN P F
Sbjct: 295 LNGLLDRENPLYSH-GFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEY 353
Query: 2617 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISG----- 2671
+ ++ ++ + DKDE L + N FII P S
Sbjct: 354 SVAITELAQVGFALPLF-IQVVDKDENLGLNSMFEVYLVGNNS--HHFIISPTSVQGKAD 410
Query: 2672 -LIQTAQRLDRESQAVYSLILVASDLGQPVP-YETMQPLQVALEDIDDNEPLFVRPPKGS 2729
I+ A LD E+ Y L A+ + VP + +++ L + +DN P+F +P
Sbjct: 411 IRIRVAIPLDYETVDRYDFDLFAN---ESVPDHVGYAKVKITLINENDNRPIFSQPLYNI 467
Query: 2730 PQYQLLTV 2737
Y+ +TV
Sbjct: 468 SLYENVTV 475
Score = 78.2 bits (191), Expect = 1e-13
Identities = 93/429 (21%), Positives = 169/429 (39%), Gaps = 66/429 (15%)
Query: 2609 PVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP 2668
P F T L I E+ P+ S+V ++ A D D N + + +G FF ++P
Sbjct: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFG---VSGEEASRFFAVEP 82
Query: 2669 ISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKG 2728
+G++ Q LDRE+++ +++ SD + + + + + D++DN P F P
Sbjct: 83 DTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT----RKVNIQVGDVNDNAPTFHNQPYS 138
Query: 2729 SPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVL 2788
+ +PE++P GT + + A D D G V Y ++ G + V+
Sbjct: 139 ------VRIPENTPVGTPIF-IVNATDPDLGAGGSVLYSFQPPSQFFAID-SARGIVTVI 190
Query: 2789 RDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTK 2848
R+LD E + V A+ P TL + +++ D+ D P F
Sbjct: 191 RELDYETTQAYQLTVNATDQDKTRPLS------------TLANLAIIITDVQDMDPIFIN 238
Query: 2849 AEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMG 2908
Y+ + + G+ + + A+D D G + Y+I+ S + +F +
Sbjct: 239 LPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV-----------SGNTNSIFALD 287
Query: 2909 SMDGILRTFDLFMAYSPGY---FVVDIVARDLAGHNDTAIIGIYILRDDQRVKIVINEIP 2965
+ G+L L +P Y F++ + +L ND D V N +
Sbjct: 288 YISGVLTLNGLLDRENPLYSHGFILTVKGTEL---NDDR------TPSDATVTTTFNILV 338
Query: 2966 DRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
+ EF N+ + + +V FA L I VV++D N L+
Sbjct: 339 IDINDNAPEF------------NSSEYSVAITELAQVGFA-LPLFIQVVDKDENLGLNSM 385
Query: 3026 RVIQMIDEN 3034
+ ++ N
Sbjct: 386 FEVYLVGNN 394
>gi|16933557 dachsous 1 precursor [Homo sapiens]
Length = 3298
Score = 922 bits (2383), Expect = 0.0
Identities = 832/2834 (29%), Positives = 1281/2834 (45%), Gaps = 228/2834 (8%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDNDPLV---FGVSGEEASRFFAVEPDTGVVWLRQP---- 92
L + E T G+ A+D D L + +SG+ A F +E G P
Sbjct: 150 LQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVV 209
Query: 93 ---LDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDNAPTFHNQPYSVRIPENTP 146
LDRE +S + ++ D R +++ + D+ND+AP F+ Y + E+
Sbjct: 210 TGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLA 269
Query: 147 VGTPIFIVNATDPDLGAGGSVLYSFQPPSQF----FAIDSARGIVTVIRELDYETTQAYQ 202
G+P+ V A+D D G G+V Y F+ID+ G++ + R LD+E + ++
Sbjct: 270 PGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHE 329
Query: 203 LTVNATDQDKTRPLSTLANLAIIITDVQDMDP----IFINLPYSTNIYEHSPPGTTVRII 258
L V A D L + A + + + D D P IF++ S + E +PPG V I
Sbjct: 330 LVVQARDGGAHPELGS-AFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVARI 388
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
+ D D G + ++ G + FAL V+ L + R + + L V T+
Sbjct: 389 SVSDPDDGDFAHVNVSLEGGEGH--FALSTQDSVIYLVCVARRLDREERDAYNLRVTATD 446
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
++A F + V D+NDNAP F+ Y L +V ++V +D
Sbjct: 447 SGSPPLRAEA----AFVLHVTDVNDNAPAFDRQLYRP--EPLPEVALPGSFVVRVTARDP 500
Query: 379 NLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-S 436
+ G N L G ++H F I PTS I A LDYE + + A +
Sbjct: 501 DQGTNGQVTYSLAPGAHTHWFSIDPTSG------IITTAASLDYELEPQPQLIVVATDGG 554
Query: 437 VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVS 496
+P A V + L + NDN P F + YN SL E GT L V ATD D+G FG +S
Sbjct: 555 LPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLS 614
Query: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYEL-IQRFTLTIIARDGGGEETTGRVRIN 550
Y S F +D +G + LD + F T+ A DGGG ++ V++
Sbjct: 615 YSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGGGLKSMVYVKVF 674
Query: 551 VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
+ D NDN P F Y ++ P T ++RLRA D D + +++Y I++ ++ +
Sbjct: 675 LSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLF- 733
Query: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT 670
+L E G+++V+ PL + +N ++ L + A D G + V I + PP
Sbjct: 734 --TLDEQSGLLTVAWPL--ARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPGTPTPPI 789
Query: 671 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGE 727
F + Y SV E++ G +V + A + + SL G F ++A SG
Sbjct: 790 FEQLQYVFSVPEDVAPGTSVGIVQA----HNPPGRLAPVTLSLSGGDPRGLFSLDAVSGL 845
Query: 728 ITTTSLLDRETKSEYI-LIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYIN 786
+ T LDRE + L VRA G G +A V + L D+NDN P + +
Sbjct: 846 LQTLRPLDRELLGPVLELEVRA---GSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVL 902
Query: 787 LVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPNKFYSLNSTTGKIRTTHAMLDRENP 845
L T P + + T+ A+DPD G N + ++ + ++++ TTG +R + P
Sbjct: 903 LPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGP 962
Query: 846 DPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
HE EL D G PP + V V + P F + + ++ G A
Sbjct: 963 -AHELEL------EARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTA 1015
Query: 906 GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRV 965
G + QV A D G ++Y + F + SG + LDRE Y L+V
Sbjct: 1016 GTQVLQVQAQAPD---GGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKV 1072
Query: 966 VA---SDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDN 1022
+A S A ++ T+T+ + +L+ N+ +P ++V+E+ P V + TD
Sbjct: 1073 MAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDR 1132
Query: 1023 DVGLNAELSYFITGGNVDGK-FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKR 1081
D G N L+Y + + D K F + + V T+ LDRE ++Y L+++ D G +
Sbjct: 1133 DSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRS 1192
Query: 1082 HTGTATVFVTVLDVNDNRPIFLQSSYEA------SVPEDIPEGHSILQLKATDADEGEFG 1135
TG TV V VLD+NDN P FLQ+S A VP+ +P G + L+A D DEGE G
Sbjct: 1193 TTG--TVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENG 1250
Query: 1136 RVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVI 1195
+ Y L G F +H +G L+ PL R +VL + A++ P +S++++
Sbjct: 1251 TILY-TLTGPGSELFSLHPHSGELLTA-APLIRAERPHYVLTLSAHDQGSPPRSASLQLL 1308
Query: 1196 VYV---EDINDEAPVFTQQQYSR-----LGLRETAGIGTSVIVVQATDRDSGDGGLVNYR 1247
V V + + P ++ + L + G+ ++ + G + Y
Sbjct: 1309 VQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYT 1368
Query: 1248 ILSGA--EGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLN 1305
++ GA EG F +D ++G + LD+E + + V + + +
Sbjct: 1369 LVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQD 1428
Query: 1306 ELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN-QITYRFNAYTSTQAKALFKI 1364
E + A F+ A+ EN G + +A D R+ ++
Sbjct: 1429 ENEHAPAFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRL 1488
Query: 1365 DAITGVITVQGLVDREKGDFYTLTVVADD----GGPKVDSTVKVYITVLDENDNSPRFDF 1420
DA TG ++ +DRE L V A D + + V + V DENDN+P F
Sbjct: 1489 DARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAP--VF 1546
Query: 1421 TSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVF 1480
S S V +PED P G V A DPD G +V + LASG G F + + S G +
Sbjct: 1547 ASPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRL---HSSTGALS 1602
Query: 1481 VARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNEN 1540
V RPLDRE+ ++L VVASD G+PPR +L V++ D+ND P + Y+V + EN
Sbjct: 1603 VVRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQ-EYSVLLREN 1661
Query: 1541 VGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFY 1600
GT+++ +RATD D+G N ++Y G +F +D +G + T A DRE Q
Sbjct: 1662 NPPGTSLLTLRATDPDVGANGQVTY---GGVSSESFSLDPDTGVLTTLRA-LDREEQEEI 1717
Query: 1601 HLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQAL 1660
+L +D G+P V V + DEND+AP F H + + EG D +L ++A
Sbjct: 1718 NLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDP--QTLTMLRAS 1775
Query: 1661 DLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPIL 1720
D D G NG + Y I+ G+ F +D G + LD E+ I P L
Sbjct: 1776 DPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPAL 1835
Query: 1721 SHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQV 1779
S L T TVL D ND+ P FP EV E P G + AHD D+G NG V
Sbjct: 1836 SATLLLTVTVL----DANDHAPAFPVPAYS-VEVPEDVPAGTLLLQLQAHDPDAGANGHV 1890
Query: 1780 EYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARD-RGMPPLSSTMLVG 1838
Y + G G F++ P G LR LDRE Y ++ A D PLS+T+ V
Sbjct: 1891 TYYLGAG-TAGAFLLEPSSGELRTA--AALDREQCPSYTFSVSAVDGAAAGPLSTTVSVT 1947
Query: 1839 IRVLDINDNDPVLLNLPMNITISENSPVSS----FVAHVLASDADSGCNARLTFNITAGN 1894
I V D+ND+ P P+ + + P S +A + A D D+G NA + + + AG
Sbjct: 1948 ITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL-AGT 2006
Query: 1895 RERAFFINATTGIVTVNR-PL---DRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
+++ TG + V R P+ R+R+ L I D R AR ++++ L
Sbjct: 2007 PPPGTTVDSYTGEIRVARSPVALGPRDRV----LFIVATD---LGRPARSATGVIIVGLQ 2059
Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTV--------LNGPILALDADQDIYAVVTYQL 2002
E + P F +++ +A + EN+P GTP+ NGPI TY +
Sbjct: 2060 GEAERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPI-------------TYSI 2106
Query: 2003 L-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILD 2061
L G + G F I STG +TVRS +D E P L L+L AE G T L +T+ D
Sbjct: 2107 LSGNEKGTFSIQPSTGAITVRSAEGLDFEV--SPRLRLVLQAESGGAFAFTV-LTLTLQD 2163
Query: 2062 DNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHL- 2120
NDN P F L E+ P +LQV A D D G G++ Y + A R L H+
Sbjct: 2164 ANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVD 2223
Query: 2121 -VTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
TG I A +DRE RL ++ATDRG+ L G+A +T+++ D ND+RP P +
Sbjct: 2224 PTTGTITT-TAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQPWE 2282
Query: 2180 TVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
+ V E A G+ IA +T D D P L Y + +D F+V G
Sbjct: 2283 -LRVSEDALLGSEIAQVTGNDVDSGPVLWYVL-----------SPSGPQDPFSVGRYGGR 2330
Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
V + P++ E Y++ L D + A LTV V DVNDN P F +
Sbjct: 2331 VSLTGPLDFEQCDRYQLQLLAHDGPHE--------GRANLTVLVEDVNDNAPAFSQ---S 2379
Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 2359
Y +LE PG+ +++V+A D D G NG ++Y L V + + ++
Sbjct: 2380 LYQVMLLEHTPPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVGTVA 2439
Query: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
+ ++ ++ + A D+G+P RAA V++++ D ND+ P F Y+ AV ED+P G+
Sbjct: 2440 LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGS 2499
Query: 2420 IILTVTATDAD-SGNFALIEYSL--GDGESKFAINP--------------TTGDIYVLSS 2462
+LT+ ATDAD S + A ++YS+ G+ F + P G + +L
Sbjct: 2500 TLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEP 2559
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENE 2522
LD E Y LT A D + + V V + VLDVND P F++ + +V E+
Sbjct: 2560 LDFESLTQYNLTVAAADR----GQPPQSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDT 2615
Query: 2523 PAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
P G ++ + A+D D GP+G + +++ G F +D SG + L ++ + L
Sbjct: 2616 PVGAELLHVEASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQARHQL 2675
Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
V A D + + +EV DVND+ P F P N + E P + V ++A D
Sbjct: 2676 VVQAADPAGAH-FALAPVTIEVQDVNDHGPAF--PLNLLSTSVAENQPPGTLVTTLHAID 2732
Query: 2640 KDEGLNGAVRYSFLKTA-GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQ 2698
D G G +RYS L+ G E F ++ +G ++ D E + L++ A+D G
Sbjct: 2733 GDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHTESFRLLVGAADAGN 2792
Query: 2699 PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE 2758
+ V + D+ +P+F+ P + +Q VPE + RG +G+V A D D
Sbjct: 2793 ---LSASVTVSVLVTGEDEYDPVFLAP---AFHFQ---VPEGARRGHSLGHVQ-ATDEDG 2842
Query: 2759 GPNAIVYYFIAAGN 2772
G + +V Y +A +
Sbjct: 2843 GADGLVLYSLATSS 2856
Score = 831 bits (2147), Expect = 0.0
Identities = 838/2969 (28%), Positives = 1298/2969 (43%), Gaps = 254/2969 (8%)
Query: 18 ISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEEAS 75
+ G WGQ L L I E+ P G+ + + A PL++ +S +E S
Sbjct: 37 VPGAWGQAGSLD----------LQIDEEQPAGTLIGDISAGLPAGTAAPLMYFISAQEGS 86
Query: 76 RF---FAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTF 132
A++ +GVV + LDRE + + F+ G T +V ++V D+ND+AP F
Sbjct: 87 GVGTDLAIDEHSGVVRTARVLDREQRDRY--RFTAVTPDGA-TVEVTVRVADINDHAPAF 143
Query: 133 HNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLY--SFQPPSQFFAIDSARG----- 185
++++PE+T GT + A D D G G+ Y S + F +++ G
Sbjct: 144 PQARAALQVPEHTAFGTRYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTP 203
Query: 186 --IVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYST 243
+ V ELD E Y L + A D + P A L + + D+ D P F Y
Sbjct: 204 VPELVVTGELDRENRSHYMLQLEAYD-GGSPPRRAQALLDVTLLDINDHAPAFNQSRYHA 262
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI--VSGNTNSIFALDYISGVLTLNGLLDR 301
+ E PG+ V + A D D G + Y I + F++D +G+L L LD
Sbjct: 263 VVSESLAPGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDF 322
Query: 302 ENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE----FNSSEYSVAI 357
E L V+ + A VT + V D NDN P F S++ S +
Sbjct: 323 EQRRVHE---LVVQARDGGAHPELGSAFVT----VHVRDANDNQPSMTVIFLSADGSPQV 375
Query: 358 TELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAI 417
+E A G L I V D D+ G + V L G H + S Q + VA
Sbjct: 376 SEAAPPG-QLVARISVSDPDD--GDFAHVNVSLEGGEGHFAL----STQDSVIYLVCVAR 428
Query: 418 PLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNIS-LYENVTV 475
LD E D Y+ + A +S P A + + + NDN P F + LY L E
Sbjct: 429 RLDREERDAYNLRVTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALP 488
Query: 476 GTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELIQRFTLTI 533
G+ V+ V A D D GT G+V+Y + FS+D +G+I A LDYEL + L +
Sbjct: 489 GSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIV 548
Query: 534 IARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP 591
+A DGG ++ V + + DVNDN P FQ+ Y +L E T +++ ATD DS
Sbjct: 549 VATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSG 608
Query: 592 PNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL 651
P ++YS+ + + G + +R LD +Q + + TV A+D G L
Sbjct: 609 PFGLLSYSLGAGLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDF-TVTAVDGGG--L 665
Query: 652 NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIY 711
S V V + + DENDNPP F Y S+ G VL L A D D+ I
Sbjct: 666 KSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHIL 725
Query: 712 SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDI 771
+ F ++ +SG +T L R S L + A DG G Q A V+I+++
Sbjct: 726 AGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDG--GGLQAEPSARVDISIVPG 783
Query: 772 NDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNST 829
P ++ Y ++ E P + V V A +P G + S+ P +SL++
Sbjct: 784 TPTPPIFEQLQYVFSVPEDVAPGTSVGIVQAHNPP-GRLAPVTLSLSGGDPRGLFSLDAV 842
Query: 830 TGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT 889
+G ++T P + EL+ ++ G A + A V V L D+NDN P
Sbjct: 843 SGLLQTLR---------PLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPA 893
Query: 890 FQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVT 949
F + G IY + A+D D G+N V++ + G F ++ ++G V
Sbjct: 894 FPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGGGGA-FTVDPTTGHVRL 952
Query: 950 TTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDE--TPTFFPAVYNVSVSED 1007
L ++L + A D G+P ++S L + V DV P F Y V +
Sbjct: 953 MRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSG 1012
Query: 1008 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1067
+V+ + D G ++Y + F + + + LDRE Y+
Sbjct: 1013 TTAGTQVLQVQAQAPDGG---PITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYI 1069
Query: 1068 LILEAIDNGPVG-KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKA 1126
L + A+ + TGTATV V++L+ N++ P + +V E+ P G S+ ++ A
Sbjct: 1070 LKVMAVSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFA 1129
Query: 1127 TDADEGEFGRVWYRILH-GNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
TD D G GR+ Y + FRIH G + + LDRE+ SS+ L+V+ +
Sbjct: 1130 TDRDSGPNGRLTYSLQQLSEDSKAFRIHPQTGEVTT-LQTLDREQQSSYQLLVQVQDGGS 1188
Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLG-----LRETAGIGTSVIVVQATDRDSGD 1240
P ++ V V V D+ND +P F Q + G + + GT V +QA D D G+
Sbjct: 1189 PPRSTTGTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGE 1248
Query: 1241 GGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVY 1300
G + Y + F + +G ++T L + Y++ +SA DQ P +
Sbjct: 1249 NGTILYTLTGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLL 1308
Query: 1301 ITLLNEL------DEAVQFSNASYEAAIL-----ENLALGTEIVRVQAYSIDNLNQITYR 1349
+ +L + + A+ +L E L G+ + V A + +TY
Sbjct: 1309 VQVLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTY- 1367
Query: 1350 FNAYTSTQAKALFKIDAITGVITVQGLVDREKG-DFYTLTVVADDGGPKVDSTVKVYITV 1408
+ F +DA +G + + +D E G + LTV A+ G ++V + V
Sbjct: 1368 -TLVGGADPEGTFALDAASGRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQV 1426
Query: 1409 LDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDA-GSNGQVVFSLASGNIAGAF 1467
DEN+++P F A+++PE+ G + T +A D D G N V + L
Sbjct: 1427 QDENEHAPAF-ARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQE--PPV 1483
Query: 1468 EIVTTNDSIGEVFVARPLDREELDHYILQVVASDR---GTPPRKKDHILQVTILDINDNP 1524
+ + G + R LDRE +L V A+DR + R +V + D NDN
Sbjct: 1484 PALRLDARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNA 1543
Query: 1525 PVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE 1584
PV SP V + E+ G A + V A D D+G + +SY + G D FR+ +G
Sbjct: 1544 PVFASP--SRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGG-DGHFRLHSSTGA 1600
Query: 1585 IATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLD 1644
++ P DRE+++ + L D G+P SAT + V++ D ND AP FQQ Y VLL
Sbjct: 1601 LSV-VRPLDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLR 1659
Query: 1645 EGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISH 1704
E + TSL+T++A D D G NG VTY V+ +F +D GV+T + LD E
Sbjct: 1660 EN-NPPGTSLLTLRATDPDVGANGQVTYGGVSS---ESFSLDPDTGVLTTLRALDRE-EQ 1714
Query: 1705 GRYTLIVTATDQ--CPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR 1762
L V A D+ P L+H TV V V D ND+ PTF + EV EGQ
Sbjct: 1715 EEINLTVYAQDRGSPPQLTH-----VTVRVAVEDENDHAPTFGSAHLS-LEVPEGQDPQT 1768
Query: 1763 VWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTIC 1822
+ A D D G NGQ++Y I+DGDP G FV+ G + LDRE + L I
Sbjct: 1769 LTMLRASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMR--PLDREVEPAFQLRIE 1826
Query: 1823 ARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGC 1882
ARD G P LS+T+L+ + VLD ND+ P ++ + E+ P + + + A D D+G
Sbjct: 1827 ARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGA 1886
Query: 1883 NARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDY 1942
N +T+ + AG AF + ++G + LDRE+ P Y ++S D ++
Sbjct: 1887 NGHVTYYLGAGT-AGAFLLEPSSGELRTAAALDREQCPSYTFSVSAVDGAAAGPLSTT-- 1943
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL 2002
+ I + D ND+ P F S + + P+ + T+ + A D D A + Y+L
Sbjct: 1944 VSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRL 2003
Query: 2003 LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAHLLITIL 2060
G ++S TG + V + A P L ++A D+G ++T +++ +
Sbjct: 2004 AGTPPPGTTVDSYTGEIRVARSPV----ALGPRDRVLFIVATDLGRPARSATGVIIVGLQ 2059
Query: 2061 DDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIH 2119
+ + P F A+ + EN PPG ++ A G NG + Y I +G + F I
Sbjct: 2060 GEAERGPRFPRASSEATIRENAPPGTPIVSPRAV-HAGGTNGPITYSILSGNEKGTFSIQ 2118
Query: 2120 LVTGVIRVGNAT-IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPI 2178
TG I V +A +D E RL + A G + ++T+ + D ND+ P FL P
Sbjct: 2119 PSTGAITVRSAEGLDFEVSPRLRLVLQAESGGAFAFT---VLTLTLQDANDNAPRFLRPH 2175
Query: 2179 QTVSVLESAEPGTVIANITA--IDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNIN 2236
+ ES + + A +D ++ Y + A L F V+
Sbjct: 2176 YVAFLPESRPLEGPLLQVEADDLDQGSGGQISY---SLAASQPARGL-------FHVDPT 2225
Query: 2237 TGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF-KP 2295
TG++ + ++RE+ A + L D S V +A LTV V+D NDN P +P
Sbjct: 2226 TGTITTTAILDREIWAETRLVLMATDRGS-----PALVGSATLTVMVIDTNDNRPTIPQP 2280
Query: 2296 FGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355
+ + R+ E A G+ + V D D +G V + +L P G+V
Sbjct: 2281 WEL-----RVSEDALLGSEIAQVTGNDVD---SGPVLWYVLSPSGPQDPFSVGRYGGRVS 2332
Query: 2356 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415
+D+E+ + A D G A + V +E D+NDN P F Q YQ + E
Sbjct: 2333 LTGPLDFEQCDRYQLQLLAHD-GPHEGRANLTVLVE--DVNDNAPAFSQSLYQVMLLEHT 2389
Query: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTA 2475
P G+ IL+V+ATD DSG I Y L F+++P G ++ + A
Sbjct: 2390 PPGSAILSVSATDRDSGANGHISYHLASPADGFSVDPNNGTLFTIVG----------TVA 2439
Query: 2476 LAKDNPG--DVASNRRENS-------VQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGT 2526
L D G DV R++ V +Q+ D ND P F+ + +V E+ P G+
Sbjct: 2440 LGHDGSGAVDVVLEARDHGAPGRAARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGS 2499
Query: 2527 SVITMMATDQD-EGPNGELTYSL---------------------EGPGVEAFHVDMDSGL 2564
+++T+ ATD D + + YS+ GPG A G
Sbjct: 2500 TLLTLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGESAGPGPRAL------GC 2553
Query: 2565 VTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHI 2622
+ PL +S +++LTV A D G+PP + V V+DVNDN PVF R + +
Sbjct: 2554 LVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVNDNPPVFTRA--SYRVTV 2611
Query: 2623 REEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRE 2682
E+ P+ + + V A+D D G +G VR++ + F +D SG ++ A LD E
Sbjct: 2612 PEDTPVGAELLHVEASDADPGPHGLVRFT---VSSGDPSGLFELDESSGTLRLAHALDCE 2668
Query: 2683 SQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLT-VPEHS 2741
+QA + L++ A+D + + P+ + ++D++D+ P F P L T V E+
Sbjct: 2669 TQARHQLVVQAAD--PAGAHFALAPVTIEVQDVNDHGPAF-------PLNLLSTSVAENQ 2719
Query: 2742 PRGTLVGNVTGAVDADEGP-NAIVYYFIAAG---NEEKNFHLQPD-GCLLVLRDLDRERE 2796
P GTLV A+D D G + Y + AG + F L G L D E
Sbjct: 2720 PPGTLV-TTLHAIDGDAGAFGRLRYSLLEAGPGPEGREAFALNSSTGELRARVPFDYEHT 2778
Query: 2797 AIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVA 2856
F +V G + +L A +T V V++ ++ P F + V
Sbjct: 2779 ESFRLLV------------GAADAGNLSASVT---VSVLVTGEDEYDPVFLAPAFHFQVP 2823
Query: 2857 TDAKVGSELIQVLALDADIGNNSLVFYSI 2885
A+ G L V A D D G + LV YS+
Sbjct: 2824 EGARRGHSLGHVQATDEDGGADGLVLYSL 2852
Score = 816 bits (2107), Expect = 0.0
Identities = 810/2782 (29%), Positives = 1226/2782 (44%), Gaps = 283/2782 (10%)
Query: 245 IYEHSPPGTTVRIITAIDQDKGRPRGIGYTIV-------SGNTNSIFALDYISGVLTLNG 297
I E P GT + I+A G P G ++ + A+D SGV+
Sbjct: 51 IDEEQPAGTLIGDISA-----GLPAGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTAR 105
Query: 298 LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAI 357
+LDRE + T TP ATV T + V DIND+AP F + ++ +
Sbjct: 106 VLDREQ---RDRYRFTAV--------TPDGATVEVT--VRVADINDHAPAFPQARAALQV 152
Query: 358 TELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPT--SVQGKADIRIRV 415
E G PL +D + G L G+ + T G + V
Sbjct: 153 PEHTAFGTRYPL---EPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVV 209
Query: 416 AIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVT 474
LD E Y L A + P A + +TL++ ND+ P F+Q Y+ + E++
Sbjct: 210 TGELDRENRSHYMLQLEAYDGGSPPRRAQALLDVTLLDINDHAPAFNQSRYHAVVSESLA 269
Query: 475 VGTSVLTVLATDNDAGTFGEVSYFF----SDDPDRFSLDKDTGLIMLIARLDYELIQRFT 530
G+ VL V A+D DAG G V+Y S+ FS+D TGL+ L LD+E +
Sbjct: 270 PGSPVLQVFASDADAGVNGAVTYEINRRQSEGDGPFSIDAHTGLLQLERPLDFEQRRVHE 329
Query: 531 LTIIARDGGGEETTGR--VRINVLDVNDNVPTFQKDAYVGALRENEPSVTQ-------LV 581
L + ARDGG G V ++V D NDN P+ + + P V++ +
Sbjct: 330 LVVQARDGGAHPELGSAFVTVHVRDANDNQPSM---TVIFLSADGSPQVSEAAPPGQLVA 386
Query: 582 RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY-GVISVSRPLDYEQISNGLIYLT 640
R+ +D P + + VS +F +S + ++ V+R LD E+ L
Sbjct: 387 RISVSD---PDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREE--RDAYNLR 441
Query: 641 VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI-MAGATVLFLNATDLD 699
V A D+G+PPL + + V D NDN P F + Y + + + G+ V+ + A D D
Sbjct: 442 VTATDSGSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPD 501
Query: 700 RSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
+ GQ + YSL F I+ SG ITT + LD E + + LIV A DGG+
Sbjct: 502 QGTN-GQ--VTYSLAPGAHTHWFSIDPTSGIITTAASLDYELEPQPQLIVVATDGGLPPL 558
Query: 757 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 816
+ ATV++ L D+NDN P ++ Y +L E T P + V A D D G G L YS
Sbjct: 559 ASS--ATVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDADSGPFGLLSYS 616
Query: 817 I--------QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPL 868
+ PP + +++ +G + TT + + P + V+ D G L
Sbjct: 617 LGAGLGSSGSPP---FRIDAHSGDVCTTRTLDRDQGPSSFD------FTVTAVDGGG--L 665
Query: 869 KATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYR 928
K+ VF++ D NDN P F + A + P G ++ ++ A D D+G +G +SY
Sbjct: 666 KSMVYVKVFLS--DENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYH 723
Query: 929 MPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDV 988
+ G F ++ SG++ L R + QL + A D G ++ + I ++
Sbjct: 724 ILAGNSPPLFTLDEQSGLLTVAWPLARRANSVVQLEIGAEDGGGLQAEPSARVDISIVPG 783
Query: 989 NDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYR 1048
P F Y SV EDV V + N G A ++ ++GG+ G FS+
Sbjct: 784 TPTPPIFEQLQYVFSVPEDVAPGTSVGIVQA-HNPPGRLAPVTLSLSGGDPRGLFSLDAV 842
Query: 1049 DAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYE 1108
+++T+ LDRE +L LE V A V V + DVNDN P F
Sbjct: 843 SGLLQTLRPLDRELLGP-VLELEVRAGSGVPPAFA-VARVRVLLDDVNDNSPAFPAPEDT 900
Query: 1109 ASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDR 1168
+P + G I L+A D D G RV + +L G G F + + G + R RPL
Sbjct: 901 VLLPPNTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHV-RLMRPLGP 958
Query: 1169 ERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDE--APVFTQQQYSRLGLRETAGIGT 1226
+H L +EA + P S R+ V V+D+ AP F Y R+ L GT
Sbjct: 959 SGGPAHELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTY-RVDLPSGTTAGT 1017
Query: 1227 SVIVVQATDRDSGDGGLVNYRILS-GAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA 1285
V+ VQA + DGG + Y + + GA F ++ +G + LD E + Y++ V A
Sbjct: 1018 QVLQVQA---QAPDGGPITYHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMA 1074
Query: 1286 TDQAPPF---NQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
+ G +V +++LN+ + + + S A+ EN GT + RV A D+
Sbjct: 1075 VSGSKAELGQQTGTATVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGRVFATDRDS 1134
Query: 1343 LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDST 1401
++ ++ F+I TG +T +DRE+ Y L V DGG P +T
Sbjct: 1135 GPNGRLTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTT 1194
Query: 1402 VKVYITVLDENDNSPRFDFTSDSA-----VSIPEDCPVGQRVATVKAWDPDAGSNGQVVF 1456
V++ VLD NDNSP F S +A + +P+ P G V T++A DPD G NG +++
Sbjct: 1195 GTVHVAVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILY 1254
Query: 1457 SLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVT 1516
+L E+ + + GE+ A PL R E HY+L + A D+G+PPR L V
Sbjct: 1255 TLTGPGS----ELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQ 1310
Query: 1517 IL----------DINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYY 1566
+L D+ + P P V+ E + G+ + V A + G+ ++
Sbjct: 1311 VLPSARLAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPE-PAGVGALTYTL 1369
Query: 1567 ITEGNKDMAFRMDRISGEI-ATRP-----APPDRERQSFYHLVATVEDEGTPTLSATT-H 1619
+ + + F +D SG + RP PP R TV EG A
Sbjct: 1370 VGGADPEGTFALDAASGRLYLARPLDFEAGPPWR--------ALTVRAEGPGGAGARLLR 1421
Query: 1620 VYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLD-EGPNGTVTYAIVAGN 1678
V V + DEN++AP F + + L E P+ +L T +A D D GPN V Y ++
Sbjct: 1422 VQVQVQDENEHAPAFARDPLALALPENPEP-GAALYTFRASDADGPGPNSDVRYRLLRQE 1480
Query: 1679 I-VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDI 1737
V R+D G ++A + LD E + L+V ATD+ S R + + V V D
Sbjct: 1481 PPVPALRLDARTGALSAPRGLDRETTPA-LLLLVEATDRPANASRRRAARVSARVFVTDE 1539
Query: 1738 NDNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISP 1796
NDN P F + E QP GP +A D D G +V Y + G G F +
Sbjct: 1540 NDNAPVFASPSR--VRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGD-GHFRLHS 1596
Query: 1797 VEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPM 1856
G L V + LDRE A + LT+ A D G PP S+T ++ + V D+ND P
Sbjct: 1597 STGALSVVRP--LDREQRAEHVLTVVASDHGSPPRSATQVLTVSVADVNDEAPTFQQQEY 1654
Query: 1857 NITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDR 1916
++ + EN+P + + + A+D D G N ++T+ G +F ++ TG++T R LDR
Sbjct: 1655 SVLLRENNPPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALDR 1711
Query: 1917 ERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT 1976
E E LT+ +D P++ + + + + DEND+ P F + EV E T
Sbjct: 1712 EEQEEINLTVYAQDRGSPPQLT---HVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQT 1768
Query: 1977 PLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVV-TVRSGVIIDREAFSP 2034
LT+L A D D + Y++L G SG F ++ ++G T+R +DRE
Sbjct: 1769 -LTMLR----ASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRP---LDREV--E 1818
Query: 2035 PILELLLLAEDIG--LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVT 2092
P +L + A D G L++T L +T+LD ND+ P F +V + E+ P G +LQ+
Sbjct: 1819 PAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ 1878
Query: 2093 ATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV 2152
A D D+G NG + Y + AG FL+ +G +R A +DRE+ SY +V A D
Sbjct: 1879 AHDPDAGANGHVTYYLGAGTAGAFLLEPSSGELRTA-AALDREQCPSYTFSVSAVDGAAA 1937
Query: 2153 -PLSGTAIVTILIDDINDSRPEF-LNPIQTVSVLESAEPGT-------VIANITAIDHDL 2203
PLS T VTI + D+ND P F +P++ L PG +A + A D D
Sbjct: 1938 GPLSTTVSVTITVRDVNDHAPTFPTSPLR----LRLPRPGPSFSTPTLALATLRAEDRDA 1993
Query: 2204 --NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV-KSPMNRELVATYEVTLSV 2260
N + Y + G T V+ TG + V +SP+ + + L +
Sbjct: 1994 GANASILYRLAGTPPPGTT------------VDSYTGEIRVARSPV---ALGPRDRVLFI 2038
Query: 2261 IDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAA 2320
+ P RS + + V + + P+F I E A PGT +++ A
Sbjct: 2039 VATDLGRPARSAT---GVIIVGLQGEAERGPRFPRASSE---ATIRENAPPGTPIVSPRA 2092
Query: 2321 VDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT-VDYEEVHWLNFTVRASDNGS 2379
V G NG +TY++L G ++ S+ + + +D+E L ++A G+
Sbjct: 2093 VHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVLQAESGGA 2151
Query: 2380 PPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEY 2439
A + L + D NDN P F +P Y + E P+ +L V A D D G+ I Y
Sbjct: 2152 ---FAFTVLTLTLQDANDNAPRFLRPHYVAFLPESRPLEGPLLQVEADDLDQGSGGQISY 2208
Query: 2440 SLGDGESK---FAINPTTGDIYVLSSLDRE--KKDHYILTALAKDNPGDVASNRRENSVQ 2494
SL + F ++PTTG I + LDRE + +L A + +P V S
Sbjct: 2209 SLAASQPARGLFHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGS------AT 2262
Query: 2495 VVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVE 2554
+ + V+D ND RP +P + V E+ G+ + + D D GP S GP +
Sbjct: 2263 LTVMVIDTNDNRPTIPQP-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQ-D 2320
Query: 2555 AFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFV 2612
F V G V+ PL + +++ L ++A DG P G L V V DVNDN P F
Sbjct: 2321 PFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDG---PHEGRANLTVLVEDVNDNAPAFS 2377
Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGL 2672
+ +L E P S + V ATD+D G NG + Y A F +DP +G
Sbjct: 2378 QSLYQVML--LEHTPPGSAILSVSATDRDSGANGHISYHLASPADG-----FSVDPNNGT 2430
Query: 2673 IQT---AQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGS 2729
+ T L + ++L A D G P + V L+D +D+ P F
Sbjct: 2431 LFTIVGTVALGHDGSGAVDVVLEARDHGAP-GRAARATVHVQLQDQNDHAPSFTLS---- 2485
Query: 2730 PQYQLLTVPEHSPRGTLVGNVTGAVDADEG-PNAIVYYFIAAGNEEKNFHLQPD------ 2782
Y++ + P TL+ A DAD +A V Y I +GN + F L+P
Sbjct: 2486 -HYRVAVTEDLPPGSTLL--TLEATDADGSRSHAAVDYSIISGNWGRVFQLEPRLAEAGE 2542
Query: 2783 ---------GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVR 2833
GCL++L LD E ++ V A+ RG P +V V
Sbjct: 2543 SAGPGPRALGCLVLLEPLDFESLTQYNLTVAAAD-------RGQPPQSSVVP------VT 2589
Query: 2834 VVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRA 2893
V + D+ND PP FT+A Y V D VG+EL+ V A DAD G + LV +++
Sbjct: 2590 VTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTV-------- 2641
Query: 2894 LANDSEDVGQVFTMGSMDGILR 2915
S D +F + G LR
Sbjct: 2642 ---SSGDPSGLFELDESSGTLR 2660
Score = 796 bits (2057), Expect = 0.0
Identities = 738/2515 (29%), Positives = 1148/2515 (45%), Gaps = 207/2515 (8%)
Query: 36 FDTYLLISEDTPV----GSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVW 88
FD L E P GS V ++ A+D D N + + ++ + +F+++P +G++
Sbjct: 472 FDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQVTYSLAPGAHTHWFSIDPTSGIIT 531
Query: 89 LRQPLDRETKSEFTVEFSVSDH---QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
LD E + + + +D + V++ + DVNDN P F Y+ +PE T
Sbjct: 532 TAASLDYELEPQPQLIVVATDGGLPPLASSATVSVALQDVNDNEPQFQRTFYNASLPEGT 591
Query: 146 PVGTPIFIVNATDPDLGAGGSVLYSF--------QPPSQFFAIDSARGIVTVIRELDYET 197
GT V ATD D G G + YS PP F ID+ G V R LD +
Sbjct: 592 QPGTCFLQVTATDADSGPFGLLSYSLGAGLGSSGSPP---FRIDAHSGDVCTTRTLDRDQ 648
Query: 198 -TQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
++ TV A D L ++ + + ++D D P F Y+ +I SPPGT V
Sbjct: 649 GPSSFDFTVTAVDGGG---LKSMVYVKVFLSDENDNPPQFYPREYAASISAQSPPGTAVL 705
Query: 257 IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKG 316
+ A D D+G + Y I++GN+ +F LD SG+LT+ L R ++ + G
Sbjct: 706 RLRAHDPDQGSHGRLSYHILAGNSPPLFTLDEQSGLLTVAWPLARR----ANSVVQLEIG 761
Query: 317 TELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDK 376
E D A + +I ++ P F +Y ++ E G + + +V
Sbjct: 762 AE---DGGGLQAEPSARVDISIVPGTPTPPIFEQLQYVFSVPEDVAPGTS----VGIVQA 814
Query: 377 DENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR-YDFDLFANE 435
G + + L G + + S +V G ++ PLD E + + ++ A
Sbjct: 815 HNPPGRLAPVTLSLSGGDPRG-LFSLDAVSG----LLQTLRPLDRELLGPVLELEVRAGS 869
Query: 436 SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEV 495
VP A+V++ L + NDN P F P + L N GT + T+ A D D+G V
Sbjct: 870 GVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLRALDPDSGVNSRV 929
Query: 496 SY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRINVL 552
++ + F++D TG + L+ L L + ARDGG T R+R+ V
Sbjct: 930 TFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSPPRTSHFRLRVVVQ 989
Query: 553 DVNDN--VPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
DV P F Y L + TQ+++++A D P ITY + + A S F
Sbjct: 990 DVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---ITYHLAAEGA-SSPF 1045
Query: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPL---NSTVPVTIEVFDENDN 667
+ G+ + V LD E + L L VMA+ L T V + + ++N++
Sbjct: 1046 GLEPQSGW--LWVRAALDRE--AQELYILKVMAVSGSKAELGQQTGTATVRVSILNQNEH 1101
Query: 668 PPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL----EGSTQFRINA 723
P S+ F++V EN G +V + ATD D S G+ + YSL E S FRI+
Sbjct: 1102 SPRLSEDPTFLAVAENQPPGTSVGRVFATDRD-SGPNGR--LTYSLQQLSEDSKAFRIHP 1158
Query: 724 RSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAP- 782
++GE+TT LDRE +S Y L+V+ DGG TG TV++ +LD+NDN PT+ A
Sbjct: 1159 QTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTG--TVHVAVLDLNDNSPTFLQASG 1216
Query: 783 -----YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ-PPNKFYSLNSTTGKIRTT 836
I + + PP + VTT+ A DPD GENGT++Y++ P ++ +SL+ +G++ T
Sbjct: 1217 AAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSELFSLHPHSGELLTA 1276
Query: 837 HAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLL----------DLNDN 886
++ E P + +S D G PP A S + V +L DL +
Sbjct: 1277 APLIRAERPH-------YVLTLSAHDQGSPPRSA--SLQLLVQVLPSARLAEPPPDLAER 1327
Query: 887 DPTFQNLPFVAEV--LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSS 944
DP +P V V EG+ G S+ VA G+ L + P F ++++S
Sbjct: 1328 DPA-APVPVVLTVTAAEGLRPG-SLLGSVAAPEPAGVGALTYTLVGGADPEGTFALDAAS 1385
Query: 945 GVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSV 1004
G + LD E ++ V ++ + + + V D N+ P F +++
Sbjct: 1386 GRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENEHAPAFARDPLALAL 1445
Query: 1005 SEDVPREFRVVWLNCTDND-VGLNAELSYFITGGNVD-GKFSVGYRDAVVRTVVGLDRET 1062
E+ + +D D G N+++ Y + + R + GLDRET
Sbjct: 1446 PENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLDARTGALSAPRGLDRET 1505
Query: 1063 TAAYMLILEAIDN-GPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSI 1121
T A +L++EA D +R + V V D NDN P+F S +PED P G +
Sbjct: 1506 TPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFASPS-RVRLPEDQPPGPAA 1564
Query: 1122 LQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAY 1181
L + A D D GE RV YR+ G G +FR+H S G L RPLDRE+ + HVL V A
Sbjct: 1565 LHVVARDPDLGEAARVSYRLASGGDG-HFRLHSSTGAL-SVVRPLDREQRAEHVLTVVAS 1622
Query: 1182 NHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDG 1241
+H P ++ + V V D+NDEAP F QQ+YS L LRE GTS++ ++ATD D G
Sbjct: 1623 DHGSPPRSATQVLTVSVADVNDEAPTFQQQEYSVL-LRENNPPGTSLLTLRATDPDVGAN 1681
Query: 1242 GLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301
G V Y +S F +D TG++ T+ LD E + + V A D+ P +V +
Sbjct: 1682 GQVTYGGVSSE--SFSLDPDTGVLTTLRALDREEQEEINLTVYAQDRGSPPQLTHVTVRV 1739
Query: 1302 TLLNELDEAVQFSNASYEAAILENLALGT-EIVRVQAYSIDNLNQITYRFNAYTSTQAKA 1360
+ +E D A F +A + E T ++R + Q+ YR
Sbjct: 1740 AVEDENDHAPTFGSAHLSLEVPEGQDPQTLTMLRASDPDVGANGQLQYRI---LDGDPSG 1796
Query: 1361 LFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFD 1419
F +D +G +DRE + L + A DGG P + +T+ + +TVLD ND++P F
Sbjct: 1797 AFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPALSATLLLTVTVLDANDHAPAFP 1856
Query: 1420 FTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEV 1479
+ S V +PED P G + ++A DPDAG+NG V + L +G AGAF + S GE+
Sbjct: 1857 VPAYS-VEVPEDVPAGTLLLQLQAHDPDAGANGHVTYYLGAGT-AGAFLL---EPSSGEL 1911
Query: 1480 FVARPLDREELDHYILQVVASD-RGTPPRKKDHILQVTILDINDNPPVI-ESPFGYNV-S 1536
A LDRE+ Y V A D P + +T+ D+ND+ P SP +
Sbjct: 1912 RTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITVRDVNDHAPTFPTSPLRLRLPR 1971
Query: 1537 VNENVGGGT-AVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP---P 1592
+ T A+ +RA DRD G N+ + Y + G +D +GEI +P
Sbjct: 1972 PGPSFSTPTLALATLRAEDRDAGANASILYRLA-GTPPPGTTVDSYTGEIRVARSPVALG 2030
Query: 1593 DRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNT 1652
R+R F +VAT D G P SAT + V + E + P F + E + E T
Sbjct: 2031 PRDRVLF--IVAT--DLGRPARSATGVIIVGLQGEAERGPRFPRASSEATIRENAPP-GT 2085
Query: 1653 SLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVIT--AAKELDYEISHGRYTLI 1710
+++ +A+ G NG +TY+I++GN TF I G IT +A+ LD+E+S R L+
Sbjct: 2086 PIVSPRAVHAG-GTNGPITYSILSGNEKGTFSIQPSTGAITVRSAEGLDFEVS-PRLRLV 2143
Query: 1711 VTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP--GPRVWTFLA 1768
+ A S + T + + + D NDN P F R + F + E +P GP + A
Sbjct: 2144 LQAE------SGGAFAFTVLTLTLQDANDNAPRFLRPHYVAF-LPESRPLEGP-LLQVEA 2195
Query: 1769 HDRDSGPNGQVEYSIMDGDPL-GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1827
D D G GQ+ YS+ P G F + P G + LDRE A L + A DRG
Sbjct: 2196 DDLDQGSGGQISYSLAASQPARGLFHVDPTTGT--ITTTAILDREIWAETRLVLMATDRG 2253
Query: 1828 MPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
P L + + + V+D NDN P + P + +SE++ + S +A V +D DSG L
Sbjct: 2254 SPALVGSATLTVMVIDTNDNRPTIPQ-PWELRVSEDALLGSEIAQVTGNDVDSG--PVLW 2310
Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLI 1947
+ ++ + F + G V++ PLD E+ Y+L + D P R L +
Sbjct: 2311 YVLSPSGPQDPFSVGRYGGRVSLTGPLDFEQCDRYQLQLLAHDGPHEGRAN------LTV 2364
Query: 1948 FLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS 2007
+ D NDN P F++S YQ ++E++P G+ + + A D D ++Y L
Sbjct: 2365 LVEDVNDNAPAFSQSLYQVMLLEHTPPGSAIL----SVSATDRDSGANGHISYHLASPAD 2420
Query: 2008 GLFDINSSTGVV-TVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAH--LLITILDDND 2064
G F ++ + G + T+ V + + ++++L A D G A + + + D ND
Sbjct: 2421 G-FSVDPNNGTLFTIVGTVALGHDGSG--AVDVVLEARDHGAPGRAARATVHVQLQDQND 2477
Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELV-YRIEAGAQDRFLIHLVTG 2123
+ P+F+ + V + E+ PPG ++L + ATD D + V Y I +G R + L
Sbjct: 2478 HAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSIISGNWGR-VFQLEPR 2536
Query: 2124 VIRVGNAT---------------IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIN 2168
+ G + +D E Y LTV A DRG P S VT+ + D+N
Sbjct: 2537 LAEAGESAGPGPRALGCLVLLEPLDFESLTQYNLTVAAADRGQPPQSSVVPVTVTVLDVN 2596
Query: 2169 DSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQE 2228
D+ P F V+V E G + ++ A D D P V+ D L
Sbjct: 2597 DNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFT--VSSGDPSGL----- 2649
Query: 2229 DAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
F ++ ++G++ + ++ E A +++ + D A A +T+ V DVND
Sbjct: 2650 --FELDESSGTLRLAHALDCETQARHQLVVQAADPA------GAHFALAPVTIEVQDVND 2701
Query: 2289 NTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE- 2347
+ P F + + E PGT + + A+D D G G + Y+LL+ PG E
Sbjct: 2702 HGPAFP---LNLLSTSVAENQPPGTLVTTLHAIDGDAGAFGRLRYSLLE-AGPGPEGREA 2757
Query: 2348 ---DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
+SS G++ A DYE V A+D G+ +A + V + + ++ +P+F
Sbjct: 2758 FALNSSTGELRARVPFDYEHTESFRLLVGAADAGN--LSASVTVSVLVTGEDEYDPVFLA 2815
Query: 2405 PSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYV 2459
P++ V E G + V ATD D G L+ YSL F IN TTG +Y+
Sbjct: 2816 PAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSLATSSPYFGINQTTGALYL 2870
Score = 789 bits (2037), Expect = 0.0
Identities = 801/2917 (27%), Positives = 1266/2917 (43%), Gaps = 257/2917 (8%)
Query: 139 VRIPENTPVGTPIFIVNATDPDLGAGGSVLY--SFQPPSQF---FAIDSARGIVTVIREL 193
++I E P GT I ++A P G ++Y S Q S AID G+V R L
Sbjct: 49 LQIDEEQPAGTLIGDISAGLP-AGTAAPLMYFISAQEGSGVGTDLAIDEHSGVVRTARVL 107
Query: 194 DYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGT 253
D E Y+ T D + + + D+ D P F + + EH+ GT
Sbjct: 108 DREQRDRYRFTAVTPD-------GATVEVTVRVADINDHAPAFPQARAALQVPEHTAFGT 160
Query: 254 TVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGV-------LTLNGLLDRENPLY 306
+ A D D GR GY + F L+ G L + G LDREN
Sbjct: 161 RYPLEPARDADAGRLGTQGYALSGDGAGETFRLETRPGPDGTPVPELVVTGELDRENR-- 218
Query: 307 SHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFA 366
SH ++L ++ + + A + T ++DIND+AP FN S Y ++E G
Sbjct: 219 SH-YMLQLEAYDGGSPPRRAQALLDVT----LLDINDHAPAFNQSRYHAVVSESLAPGSP 273
Query: 367 LPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR 426
+ +QV D + G+N + S P S+ + +++ PLD+E
Sbjct: 274 V---LQVFASDADAGVNGAVTYEINRRQSEGD--GPFSIDAHTGL-LQLERPLDFEQRRV 327
Query: 427 YDFDLFANES-VPDHVGYAKVKITLINENDNRP----IFSQPLYNISLYENVTVGTSVLT 481
++ + A + +G A V + + + NDN+P IF + + E G V
Sbjct: 328 HELVVQARDGGAHPELGSAFVTVHVRDANDNQPSMTVIFLSADGSPQVSEAAPPGQLVAR 387
Query: 482 VLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIA---RLDYELIQRFTLTIIARDG 538
+ +D D G F V+ F+L +I L+ RLD E + L + A D
Sbjct: 388 ISVSDPDDGDFAHVNVSLEGGEGHFALSTQDSVIYLVCVARRLDREERDAYNLRVTATDS 447
Query: 539 GGEETTGRVR--INVLDVNDNVPTFQKDAY-VGALRENEPSVTQLVRLRATDEDSPPNNQ 595
G ++V DVNDN P F + Y L E + +VR+ A D D N Q
Sbjct: 448 GSPPLRAEAAFVLHVTDVNDNAPAFDRQLYRPEPLPEVALPGSFVVRVTARDPDQGTNGQ 507
Query: 596 ITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTV 655
+TYS+ + A +F I G +I+ + LDYE L V+A D G PPL S+
Sbjct: 508 VTYSL-APGAHTHWFSIDPTSG--IITTAASLDYELEPQP--QLIVVATDGGLPPLASSA 562
Query: 656 PVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-- 713
V++ + D NDN P F + Y S+ E G L + ATD D S +G S YSL
Sbjct: 563 TVSVALQDVNDNEPQFQRTFYNASLPEGTQPGTCFLQVTATDAD-SGPFGLLS--YSLGA 619
Query: 714 ----EGSTQFRINARSGEITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIATVNITL 768
GS FRI+A SG++ TT LDR+ S + V AVDGG + V + L
Sbjct: 620 GLGSSGSPPFRIDAHSGDVCTTRTLDRDQGPSSFDFTVTAVDGG----GLKSMVYVKVFL 675
Query: 769 LDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSL 826
D NDN P + Y ++ +PP + V + A DPD G +G L Y I N ++L
Sbjct: 676 SDENDNPPQFYPREYAASISAQSPPGTAVLRLRAHDPDQGSHGRLSYHILAGNSPPLFTL 735
Query: 827 NSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDN 886
+ +G + + R N + ++ + D G L+A SA V ++++
Sbjct: 736 DEQSGLLTVAWPLARRANS-------VVQLEIGAEDGGG--LQAEPSARVDISIVPGTPT 786
Query: 887 DPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGV 946
P F+ L +V V E + G S+ +V G V+ + G PR F +++ SG+
Sbjct: 787 PPIFEQLQYVFSVPEDVAPGTSV-GIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGL 845
Query: 947 VVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSE 1006
+ T LDRE + V + +G P + + + + + DVND +P F V +
Sbjct: 846 LQTLRPLDRELLGPVLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPP 905
Query: 1007 DVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAY 1066
+ + L D D G+N+ +++ + G G F+V VR + L A+
Sbjct: 906 NTAPGTPIYTLRALDPDSGVNSRVTFTLLAGG-GGAFTVDPTTGHVRLMRPLGPSGGPAH 964
Query: 1067 MLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKA 1126
L LEA D G + V V + P F +Y +P G +LQ++A
Sbjct: 965 ELELEARDGGSPPRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQA 1024
Query: 1127 TDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNH--- 1183
D G + Y + + F + +G L LDRE ++L V A +
Sbjct: 1025 QAPDGGP---ITYHLAAEGASSPFGLEPQSGWLWVRAA-LDREAQELYILKVMAVSGSKA 1080
Query: 1184 DLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGL 1243
+LG + V V + + N+ +P ++ + L + E GTSV V ATDRDSG G
Sbjct: 1081 ELGQQTGTATVRVSILNQNEHSPRLSEDP-TFLAVAENQPPGTSVGRVFATDRDSGPNGR 1139
Query: 1244 VNYRI--LSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301
+ Y + LS F I TG + T+ LD E ++SY + V D P +V++
Sbjct: 1140 LTYSLQQLSEDSKAFRIHPQTGEVTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHV 1199
Query: 1302 TLLNELDEAVQFSNASYEAA------ILENLALGTEIVRVQAYSIDNLNQITYRFNAYTS 1355
+L+ D + F AS A + + + GT + +QA D T YT
Sbjct: 1200 AVLDLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTI---LYTL 1256
Query: 1356 T-QAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVL---- 1409
T LF + +G + + R + Y LT+ A D G P +++++ + VL
Sbjct: 1257 TGPGSELFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLVQVLPSAR 1316
Query: 1410 ------DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASG-N 1462
D + P V+ E G + +V A P+ G + ++L G +
Sbjct: 1317 LAEPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAA--PEPAGVGALTYTLVGGAD 1374
Query: 1463 IAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDIND 1522
G F + + G +++ARPLD E + V ++ + +QV + D N+
Sbjct: 1375 PEGTFALDAAS---GRLYLARPLDFEAGPPWRALTVRAEGPGGAGARLLRVQVQVQDENE 1431
Query: 1523 NPPVI-ESPFGYNVSVNENVGGGTAVVQVRATDRD-IGINSVLSYYITEGNKDM-AFRMD 1579
+ P P +++ EN G A+ RA+D D G NS + Y + + A R+D
Sbjct: 1432 HAPAFARDPLA--LALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPALRLD 1489
Query: 1580 RISGEIATRPAPPDRERQSFYHLVATVEDEGTPT-----LSATTHVYVTIVDENDNAPMF 1634
+G ++ AP +R++ L+ VE P +A V + DENDNAP+F
Sbjct: 1490 ARTGALS---APRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVF 1546
Query: 1635 QQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITA 1694
P L ++ P + + + A D D G V+Y + +G + FR+ G ++
Sbjct: 1547 ASPSRVRLPEDQPP--GPAALHVVARDPDLGEAARVSYRLASGGDGH-FRLHSSTGALSV 1603
Query: 1695 AKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEV 1754
+ LD E + L V A+D S ++T + V+V D+ND PTF +
Sbjct: 1604 VRPLDRE-QRAEHVLTVVASDHG---SPPRSATQVLTVSVADVNDEAPTFQQQEYSVLLR 1659
Query: 1755 TEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETI 1814
PG + T A D D G NGQV Y + + F + P GVL + LDRE
Sbjct: 1660 ENNPPGTSLLTLRATDPDVGANGQVTYGGVSSE---SFSLDPDTGVLTTLR--ALDREEQ 1714
Query: 1815 AFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVL 1874
NLT+ A+DRG PP + + V + V D ND+ P + +++ + E + +
Sbjct: 1715 EEINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQTLTM-LR 1773
Query: 1875 ASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN 1934
ASD D G N +L + I G+ AF ++ +G RPLDRE P ++L I +D +
Sbjct: 1774 ASDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQP 1833
Query: 1935 PRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDI 1994
A LL + + D ND+ P F Y EV E+ PAGT L L A D D
Sbjct: 1834 ALSATL---LLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQ----AHDPDAGA 1886
Query: 1995 YAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED---IGLLNS 2051
VTY L +G F + S+G +R+ +DRE P + A D G L++
Sbjct: 1887 NGHVTYYLGAGTAGAFLLEPSSG--ELRTAAALDREQC--PSYTFSVSAVDGAAAGPLST 1942
Query: 2052 TAHLLITILDDNDNRPTFSPATLTVHLLENCP----PGFSVLQVTATDEDSGLNGELVYR 2107
T + IT+ D ND+ PTF + L + L P P ++ + A D D+G N ++YR
Sbjct: 1943 TVSVTITVRDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYR 2002
Query: 2108 IEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI 2167
+ + TG IRV + + ++ L +VATD G S T ++ + +
Sbjct: 2003 LAGTPPPGTTVDSYTGEIRVARSPVALGPRDRV-LFIVATDLGRPARSATGVIIVGLQGE 2061
Query: 2168 NDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD-LNPKLEYHIVGIVAKDDTDRLVPN 2226
+ P F ++ E+A PGT I + A+ N + Y I L N
Sbjct: 2062 AERGPRFPRASSEATIRENAPPGTPIVSPRAVHAGGTNGPITYSI-----------LSGN 2110
Query: 2227 QEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDV 2286
++ F++ +TG++ V+S + + + L + E + LT+ + D
Sbjct: 2111 EKGTFSIQPSTGAITVRSAEGLDFEVSPRLRLVL------QAESGGAFAFTVLTLTLQDA 2164
Query: 2287 NDNTPQF-KPFGITYYME-RILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYV 2344
NDN P+F +P + + E R LEG L+ V A D D+G G ++Y+L P +
Sbjct: 2165 NDNAPRFLRPHYVAFLPESRPLEGP-----LLQVEADDLDQGSGGQISYSLAASQPARGL 2219
Query: 2345 QLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
D + G + +D E + A+D GSP + + ++D NDN P Q
Sbjct: 2220 FHVDPTTGTITTTAILDREIWAETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQ 2279
Query: 2405 PSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLD 2464
P ++ V ED +G+ I VT D DSG S + F++ G + + LD
Sbjct: 2280 P-WELRVSEDALLGSEIAQVTGNDVDSGPVLWYVLSPSGPQDPFSVGRYGGRVSLTGPLD 2338
Query: 2465 REKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPA 2524
E+ D Y L LA D P E + + V DVND P FS+ + + E+ P
Sbjct: 2339 FEQCDRYQLQLLAHDGP-------HEGRANLTVLVEDVNDNAPAFSQSLYQVMLLEHTPP 2391
Query: 2525 GTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLV-----TTQRPLQSYEKFSL 2579
G++++++ ATD+D G NG ++Y L P + F VD ++G + T +
Sbjct: 2392 GSAILSVSATDRDSGANGHISYHLASPA-DGFSVDPNNGTLFTIVGTVALGHDGSGAVDV 2450
Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIR----EEIPLRSNVYEV 2635
+ A D G P + V++ D ND+ P F T+ H R E++P S + +
Sbjct: 2451 VLEARDHGAPGRAARATVHVQLQDQNDHAPSF------TLSHYRVAVTEDLPPGSTLLTL 2504
Query: 2636 YATDKDEGLN-GAVRYSFLKTAGNRDW-EFFIIDP--------------ISGLIQTAQRL 2679
ATD D + AV YS + +GN W F ++P G + + L
Sbjct: 2505 EATDADGSRSHAAVDYSII--SGN--WGRVFQLEPRLAEAGESAGPGPRALGCLVLLEPL 2560
Query: 2680 DRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPE 2739
D ES Y+L + A+D GQP P ++ P+ V + D++DN P+F R Y++ TVPE
Sbjct: 2561 DFESLTQYNLTVAAADRGQP-PQSSVVPVTVTVLDVNDNPPVFTRA-----SYRV-TVPE 2613
Query: 2740 HSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHL-QPDGCLLVLRDLDREREAI 2798
+P G + +V A DAD GP+ +V + +++G+ F L + G L + LD E +A
Sbjct: 2614 DTPVGAELLHVE-ASDADPGPHGLVRFTVSSGDPSGLFELDESSGTLRLAHALDCETQAR 2672
Query: 2799 FSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATD 2858
+V+A+ P G A L V + ++D+ND P F + VA +
Sbjct: 2673 HQLVVQAAD------PAG--------AHFALAPVTIEVQDVNDHGPAFPLNLLSTSVAEN 2718
Query: 2859 AKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFD 2918
G+ + + A+D D G + YS+L A + + F + S G LR
Sbjct: 2719 QPPGTLVTTLHAIDGDAGAFGRLRYSLLE-------AGPGPEGREAFALNSSTGELRARV 2771
Query: 2919 LFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDDQ 2955
F F + + A D + + + + + +D+
Sbjct: 2772 PFDYEHTESFRLLVGAADAGNLSASVTVSVLVTGEDE 2808
Score = 664 bits (1712), Expect = 0.0
Identities = 636/2215 (28%), Positives = 983/2215 (44%), Gaps = 183/2215 (8%)
Query: 42 ISEDTPVGSSVTQLLAQDMDND--PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKS 99
+ ED G+SV + A + P+ +SG + F+++ +G++ +PLDRE
Sbjct: 799 VPEDVAPGTSVGIVQAHNPPGRLAPVTLSLSGGDPRGLFSLDAVSGLLQTLRPLDRELLG 858
Query: 100 EFTVEFSVSDHQGV----ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVN 155
+E V GV +V + + DVNDN+P F +V +P NT GTPI+ +
Sbjct: 859 P-VLELEVRAGSGVPPAFAVARVRVLLDDVNDNSPAFPAPEDTVLLPPNTAPGTPIYTLR 917
Query: 156 ATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTR 214
A DPD G V ++ F +D G V ++R L A++L + A D
Sbjct: 918 ALDPDSGVNSRVTFTLLAGGGGAFTVDPTTGHVRLMRPLGPSGGPAHELELEARDGGSP- 976
Query: 215 PLSTLANLAIIITDV--QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
P ++ L +++ DV + + P F + Y ++ + GT V + A D G I
Sbjct: 977 PRTSHFRLRVVVQDVGTRGLAPRFNSPTYRVDLPSGTTAGTQVLQVQAQAPDGGP---IT 1033
Query: 273 YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
Y + + +S F L+ SG L + LDRE ++ V G++ T T
Sbjct: 1034 YHLAAEGASSPFGLEPQSGWLWVRAALDREAQELYILKVMAVSGSKAE----LGQQTGTA 1089
Query: 333 TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG 392
T + +++ N+++P + +A+ E G ++ + D+D + + +
Sbjct: 1090 TVRVSILNQNEHSPRLSEDPTFLAVAENQPPGTSVGR-VFATDRDSGPNGRLTYSLQQLS 1148
Query: 393 NNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLI 451
+S F I P + + + LD E Y + + P V + ++
Sbjct: 1149 EDSKAFRIHPQTGE------VTTLQTLDREQQSSYQLLVQVQDGGSPPRSTTGTVHVAVL 1202
Query: 452 NENDNRPIFSQPL------YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD-PD 504
+ NDN P F Q I + + V GT V T+ A D D G G + Y + +
Sbjct: 1203 DLNDNSPTFLQASGAAGGGLPIQVPDRVPPGTLVTTLQAKDPDEGENGTILYTLTGPGSE 1262
Query: 505 RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKD 564
FSL +G ++ A L + LT+ A D G + +++ V +P+ +
Sbjct: 1263 LFSLHPHSGELLTAAPLIRAERPHYVLTLSAHDQGSPPRSASLQLLV----QVLPSARLA 1318
Query: 565 AYVGALRENEPSVTQLVRLRATDED-----------SPPN----NQITYSIVSASAFGSY 609
L E +P+ V L T + + P +TY++V +
Sbjct: 1319 EPPPDLAERDPAAPVPVVLTVTAAEGLRPGSLLGSVAAPEPAGVGALTYTLVGGADPEGT 1378
Query: 610 FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
F +L G + ++RPLD+E LTV A G + V ++V DEN++ P
Sbjct: 1379 F--ALDAASGRLYLARPLDFEA-GPPWRALTVRAEGPGGAGAR-LLRVQVQVQDENEHAP 1434
Query: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLD--------RSREYGQESIIYSLEGSTQFRI 721
F++ +++ EN GA + A+D D R R QE + +L R+
Sbjct: 1435 AFARDPLALALPENPEPGAALYTFRASDADGPGPNSDVRYRLLRQEPPVPAL------RL 1488
Query: 722 NARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGI-ATVNITLLDINDNHPTWKD 780
+AR+G ++ LDRET +L+V A D +++ + + + D NDN P +
Sbjct: 1489 DARTGALSAPRGLDRETTPALLLLVEATDRPANASRRRAARVSARVFVTDENDNAPVFA- 1547
Query: 781 APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAM 839
+P + L E PP VVA DPDLGE + Y + + L+S+TG +
Sbjct: 1548 SPSRVRLPEDQPPGPAALHVVARDPDLGEAARVSYRLASGGDGHFRLHSSTGALSVVRP- 1606
Query: 840 LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEV 899
LDRE H + V +D G PP AT TV V D+ND PTFQ + +
Sbjct: 1607 LDREQRAEHV------LTVVASDHGSPPRSATQVLTVSV--ADVNDEAPTFQQQEYSVLL 1658
Query: 900 LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA 959
E P G S+ + A D D G NG V+Y G+ F ++ +GV+ T LDRE
Sbjct: 1659 RENNPPGTSLLTLRATDPDVGANGQVTYG---GVSSESFSLDPDTGVLTTLRALDREEQE 1715
Query: 960 EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019
E L V A D G+P + + T+ + V D ND PTF A ++ V E + + L
Sbjct: 1716 EINLTVYAQDRGSPPQLTHVTVRVAVEDENDHAPTFGSAHLSLEVPEGQDPQ-TLTMLRA 1774
Query: 1020 TDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVG 1079
+D DVG N +L Y I G+ G F + T+ LDRE A+ L +EA D G
Sbjct: 1775 SDPDVGANGQLQYRILDGDPSGAFVLDLASGEFGTMRPLDREVEPAFQLRIEARDGGQPA 1834
Query: 1080 KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWY 1139
+ T + VTVLD ND+ P F +Y VPED+P G +LQL+A D D G G V Y
Sbjct: 1835 L--SATLLLTVTVLDANDHAPAFPVPAYSVEVPEDVPAGTLLLQLQAHDPDAGANGHVTY 1892
Query: 1140 RILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL-GPMRSSVRVIVYV 1198
+ G G F + S+G L R LDRE+ S+ V A + GP+ ++V V + V
Sbjct: 1893 YLGAGTAGA-FLLEPSSGEL-RTAAALDREQCPSYTFSVSAVDGAAAGPLSTTVSVTITV 1950
Query: 1199 EDINDEAPVFTQQQYSRLGLRETAGIGTSVIVV---QATDRDSGDGGLVNYRILSGAEGK 1255
D+ND AP F R T + + +A DRD+G + YR+
Sbjct: 1951 RDVNDHAPTFPTSPLRLRLPRPGPSFSTPTLALATLRAEDRDAGANASILYRLAGTPPPG 2010
Query: 1256 FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN 1315
+D TG I ++ + ATD P + + L E + +F
Sbjct: 2011 TTVDSYTGEIRVARSPVALGPRDRVLFIVATDLGRPARSATGVIIVGLQGEAERGPRFPR 2070
Query: 1316 ASYEAAILENLALGTEIVRVQAYSIDNLN-QITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
AS EA I EN GT IV +A N ITY + S K F I TG ITV+
Sbjct: 2071 ASSEATIRENAPPGTPIVSPRAVHAGGTNGPITY---SILSGNEKGTFSIQPSTGAITVR 2127
Query: 1375 GL--VDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDC 1432
+D E L + A+ GG + + +T+ D NDN+PRF +PE
Sbjct: 2128 SAEGLDFEVSPRLRLVLQAESGGAFAFTVLT--LTLQDANDNAPRF-LRPHYVAFLPESR 2184
Query: 1433 PVGQRVATVKAWDPDAGSNGQVVFSLASGNIA-GAFEIVTTNDSIGEVFVARPLDREELD 1491
P+ + V+A D D GS GQ+ +SLA+ A G F + T +I + LDRE
Sbjct: 2185 PLEGPLLQVEADDLDQGSGGQISYSLAASQPARGLFHVDPTTGTITTTAI---LDREIWA 2241
Query: 1492 HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVR 1551
L ++A+DRG+P L V ++D NDN P I P + + V+E+ G+ + QV
Sbjct: 2242 ETRLVLMATDRGSPALVGSATLTVMVIDTNDNRPTIPQP--WELRVSEDALLGSEIAQVT 2299
Query: 1552 ATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVED--- 1608
D D G VL Y ++ F + R G ++ P D E+ Y L D
Sbjct: 2300 GNDVDSG--PVLWYVLSPSGPQDPFSVGRYGGRVSLT-GPLDFEQCDRYQLQLLAHDGPH 2356
Query: 1609 EGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNG 1668
EG L+ V + D NDNAP F Q Y+V+L E ++++++ A D D G NG
Sbjct: 2357 EGRANLT------VLVEDVNDNAPAFSQSLYQVMLLEHTPP-GSAILSVSATDRDSGANG 2409
Query: 1669 TVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVTATDQCPILSHRLT 1725
++Y + + + F +D + G I L ++ S G +++ A D +
Sbjct: 2410 HISYHLASP--ADGFSVDPNNGTLFTIVGTVALGHDGS-GAVDVVLEARDHG---APGRA 2463
Query: 1726 STTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRD-SGPNGQVEYSIM 1784
+ TV V + D ND+ P+F + + PG + T A D D S + V+YSI+
Sbjct: 2464 ARATVHVQLQDQNDHAPSFTLSHYRVAVTEDLPPGSTLLTLEATDADGSRSHAAVDYSII 2523
Query: 1785 DGDPLGEFVISP--------------VEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
G+ F + P G L + + LD E++ YNLT+ A DRG PP
Sbjct: 2524 SGNWGRVFQLEPRLAEAGESAGPGPRALGCLVLLEP--LDFESLTQYNLTVAAADRGQPP 2581
Query: 1831 LSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI 1890
SS + V + VLD+NDN PV +T+ E++PV + + HV ASDAD G + + F +
Sbjct: 2582 QSSVVPVTVTVLDVNDNPPVFTRASYRVTVPEDTPVGAELLHVEASDADPGPHGLVRFTV 2641
Query: 1891 TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
++G+ F ++ ++G + + LD E ++L + D P A + I +
Sbjct: 2642 SSGDPSGLFELDESSGTLRLAHALDCETQARHQLVVQAAD----PAGAHFALAPVTIEVQ 2697
Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG-- 2008
D ND+ P F + V EN P GT +T L+ A+D D + + Y LL A G
Sbjct: 2698 DVNDHGPAFPLNLLSTSVAENQPPGTLVTTLH----AIDGDAGAFGRLRYSLLEAGPGPE 2753
Query: 2009 ---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDN 2065
F +NSSTG +R+ V D E LL+ A D G L+++ + + + +++
Sbjct: 2754 GREAFALNSSTG--ELRARVPFDYE--HTESFRLLVGAADAGNLSASVTVSVLVTGEDEY 2809
Query: 2066 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVI 2125
P F + E G S+ V ATDED G +G ++Y + A + F I+ TG +
Sbjct: 2810 DPVFLAPAFHFQVPEGARRGHSLGHVQATDEDGGADGLVLYSL-ATSSPYFGINQTTGAL 2868
Query: 2126 RV---------------GNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILID 2165
+ G RE RL V+A RG +P S +A V + +D
Sbjct: 2869 YLRVDSRAPGSGTATSGGGGRTRREAPRELRLEVIA--RGPLPGSRSATVPVTVD 2921
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 899 bits (2324), Expect = 0.0
Identities = 832/2924 (28%), Positives = 1356/2924 (46%), Gaps = 246/2924 (8%)
Query: 38 TYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLD 94
T + + E+ PVGSSV + + D+D N LV+ VSG F ++ +TG++ + PLD
Sbjct: 722 TGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLD 781
Query: 95 RETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
RET ++T+ +V D Q R +++ V D NDN P F + Y V + E+ V + I
Sbjct: 782 RETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI 841
Query: 152 FIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQD 211
V ATD DLG G V YS + F+IDS G+V + R LD E + L + A DQ
Sbjct: 842 IQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIEARDQA 901
Query: 212 KTRP-LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270
+ P L + + + + DV D P FI Y + E P GT + + A D D G+
Sbjct: 902 REEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQ 961
Query: 271 IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATV 330
+ Y+++ + F +D +SG + + LD E + LTV+ D P +
Sbjct: 962 VRYSLLDHGEGN-FDVDKLSGAVRIVQQLDFEK---KQVYNLTVRA---KDKGKPVSLSS 1014
Query: 331 TTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEV 388
T + V+D+N+N P F+S + E A VG +L + + D+D + +
Sbjct: 1015 TCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVG-SLVMTVSAHDEDARRDGEIRYSI 1073
Query: 389 YLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYAKVK 447
G+ F I G+ I + LD E+ Y +FA ++ V + ++
Sbjct: 1074 -RDGSGVGVFKI------GEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIY 1126
Query: 448 ITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY-FFSDDPDR- 505
I + + NDN P S+P+Y + EN SV+ + A D D+ + ++ Y S +P
Sbjct: 1127 IEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGF 1186
Query: 506 FSLDKDTGLIMLIAR-LDYELIQRFTLTIIARDGGG--EETTGRVRINVLDVNDNVPTFQ 562
FS+ TGLI +R LD E L + D G + T RV + +LD NDN P F
Sbjct: 1187 FSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFL 1246
Query: 563 KDAYVGALRENEPSVTQ-------LVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLY 615
+ Y L E E + L + ATD+D PN +I+YSI + G +F +
Sbjct: 1247 QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFF---IE 1303
Query: 616 EGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDE---NDNPPTFS 672
GV+S R + L++ A+D G P +ST + IE + + P +F
Sbjct: 1304 PKTGVVSSKR----FSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFE 1359
Query: 673 KPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG---STQFRINARSGEIT 729
+ + +V+E+ + + S E + + + G + F ++ +G I
Sbjct: 1360 ESFFTFTVMESDPVAHMIGVI-------SVEPPGIPLWFDITGGNYDSHFDVDKGTGTII 1412
Query: 730 TTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVE 789
LD E KS Y L V A DG T + V I ++D ND+ P + + Y + + E
Sbjct: 1413 VAKPLDAEQKSNYNLTVEATDG-----TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPE 1467
Query: 790 MTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-----KFYSLNSTTGKIRTTHAMLDREN 844
T P++++ + AVD D E L+Y++Q K + L+ TG + T+ +
Sbjct: 1468 DTAPETEILQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKL----- 1520
Query: 845 PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIP 904
HEA + V V D P + + A + VN+ D ND+ P F + V E
Sbjct: 1521 --DHEAVHQHTLTVMVRDQDVPVKR--NFARIVVNVSDTNDHAPWFTASSYKGRVYESAA 1576
Query: 905 AGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLR 964
G + QV A+D D+G N V Y + G F+I+ G + T ELDR AEY L
Sbjct: 1577 VGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLM 1636
Query: 965 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDV 1024
V A+D G+P S +++ I V ++ +P F Y+V +SE V V +
Sbjct: 1637 VKATDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHS--- 1693
Query: 1025 GLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTG 1084
+ + Y I GN F + + T LD ET Y LI++ + + +
Sbjct: 1694 --QSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGL----ST 1747
Query: 1085 TATVFVTVLDVNDNRPIFLQSSYEASVPED-------IPEGHSILQLKATDADEGEFGRV 1137
TV V + D NDN P+F+Q+ Y + E + + + L ++A DAD+ +
Sbjct: 1748 NTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALL 1807
Query: 1138 WYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMR----SSVR 1193
Y I+ + F I S G + LD E S V+ HD+G R +
Sbjct: 1808 VYHIVEPSVHTYFAIDSSTGAI-HTVLSLDYEETSIFHFTVQV--HDMGTPRLFAEYAAN 1864
Query: 1194 VIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAE 1253
V V+V DIND PVF + Y L T G VI V ATD DS + Y I G
Sbjct: 1865 VTVHVIDINDCPPVFAKPLYEASLLLPTYK-GVKVITVNATDADSSAFSQLIYSITEGNI 1923
Query: 1254 G-KFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQ 1312
G KF +D TG + N + ++ Y + V A+D G SV I + + ++
Sbjct: 1924 GEKFSMDYKTGALTVQN--TTQLRSRYELTVRASDGR---FAGLTSVKINVKESKESHLK 1978
Query: 1313 FSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVIT 1372
F+ Y A + EN + + A + +N+ + Y FKI +GV++
Sbjct: 1979 FTQDVYSAVVKENSTEAETLAVITAIG-NPINEPLF----YHILNPDRRFKISRTSGVLS 2033
Query: 1373 VQGL-VDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPE 1430
G DRE+ + + + V V ++ P + V V + V D+NDN+P F AV +
Sbjct: 2034 TTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAV-VKV 2092
Query: 1431 DCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREEL 1490
D VG + V A D D+G NG+V + L + F+I +GE+ + + + + L
Sbjct: 2093 DTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHH--EHFQI----GPLGEISLKKQFELDTL 2146
Query: 1491 D-HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQ 1549
+ Y++ VVA D G P + I+ +T++ N PV E PF Y+ + E++ + VV
Sbjct: 2147 NKEYLVTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPF-YSAEIAESIQVHSPVVH 2203
Query: 1550 VRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDE 1609
V+A + G+ + Y IT+G+ F ++ +G I AP D E Y L D
Sbjct: 2204 VQANSPE-GLK--VFYSITDGDPFSQFTINFNTGVINV-IAPLDFEAHPAYKLSIRATDS 2259
Query: 1610 GTPTLSATTHVYVTIV--DENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPN 1667
T A V+V I+ D NDN P+F Q Y V L E + TS++ ++A D D PN
Sbjct: 2260 LT---GAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEA-SVIGTSVVQVRATDSDSEPN 2315
Query: 1668 GTVTYAIVAGNIV--NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATD-QCPILSHRL 1724
++Y + + + F +D G+I+ + LDYE S ++T+ V A D P LS
Sbjct: 2316 RGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSR-QHTIFVRAVDGGMPTLS--- 2371
Query: 1725 TSTTTVLVNVNDINDNVPTFPRD-YEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYS 1782
S V V+V D+NDN P F + YE ++E P G V A+D DS +++YS
Sbjct: 2372 -SDVIVTVDVTDLNDNPPLFEQQIYEA--RISEHAPHGHFVTCVKAYDADSSDIDKLQYS 2428
Query: 1783 IMDGDPLGEFVISPVEGVLRVRKDVELDRETI-AFYNLTICARDRGMPPLSSTMLVGIRV 1841
I+ G+ FVI G++ + L R + FY+L + D S+ V + V
Sbjct: 2429 ILSGNDHKHFVIDSATGIITLS---NLHRHALKPFYSLNLSVSD---GVFRSSTQVHVTV 2482
Query: 1842 LDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFI 1901
+ N + P L + ++EN+P+ + V V +D DSG +T++I + F+I
Sbjct: 2483 IGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYI 2542
Query: 1902 NATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTK 1961
N I T+ + LDRE E +++ + ++A + + + L+D+NDN P F
Sbjct: 2543 NERGQIFTLEK-LDRETPAEKVISVRLMAKDAGGKVA---FCTVNVILTDDNDNAPQFRA 2598
Query: 1962 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGL---FDINSSTGV 2018
+ Y+ + ++ GT + +LA DAD+ A +TY + + +IN +GV
Sbjct: 2599 TKYEVNIGSSAAKGTSVV----KVLASDADEGSNADITYAIEADSESVKENLEINKLSGV 2654
Query: 2019 VTVRSGVI-IDREAFSPPILELLLLAEDIGLLNSTAHLL--ITILDDNDNRPTFSPATLT 2075
+T + +I ++ E F+ + A D G + + +L + IL P FS T
Sbjct: 2655 ITTKESLIGLENEFFT-----FFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYT 2709
Query: 2076 VHLLENCPPGFSVLQVTATDEDSGLNGELVYRI------EAGAQDRFLIHLVTGVIRVGN 2129
+ E+ P G + + A +G ++Y + E+ + F+I +G +++
Sbjct: 2710 FTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVIDRQSGRLKL-E 2763
Query: 2130 ATIDREEQESYRLTVVA-TDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAE 2188
++D E + Y+ +++A + + + V+I + D ND+ P F + ++E+
Sbjct: 2764 KSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLP 2823
Query: 2189 PGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPM 2246
G+ + I A D D N ++ Y + D + V E +FA+N+ TG + +
Sbjct: 2824 GGSRVIQIRASDADSGTNGQVMYSL-------DQSQSVEVIE-SFAINMETGWITTLKEL 2875
Query: 2247 NRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERIL 2306
+ E Y++ + D+ + S ++ + V V DVND+ P+F Y +
Sbjct: 2876 DHEKRDNYQIKVVASDHGEKIQLSSTAI----VDVTVTDVNDSPPRFT---AEIYKGTVS 2928
Query: 2307 EGATPGTTLIAVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLED-SSAGKVIANRTVDYEE 2364
E G + ++ D D + +N VTY + P G +E + KV + +D E+
Sbjct: 2929 EDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREK 2988
Query: 2365 VHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTV 2424
T+ A+D +A V ++++D NDN+P+ ++ Y + + EDV G +I+ +
Sbjct: 2989 RDNYLLTITATDGTFSSKAI---VEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQI 3045
Query: 2425 TATDADSGNFALIEYS-LGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGD 2483
+ATDAD + A I Y+ LG G KF +NP TG++ + LDRE++ Y L A D G
Sbjct: 3046 SATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGG- 3104
Query: 2484 VASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGE 2543
R +V+ + DVND P+FS ++ +V+EN GT + + ATD D G N +
Sbjct: 3105 -----RFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRK 3159
Query: 2544 LTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEP-PLWGTTMLLVE 2600
+ YSL F ++ SG++ ++PL + ++L++ A D G P L T ++V
Sbjct: 3160 ILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATGTVIVS 3219
Query: 2601 VIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRD 2660
V+D+NDN PVF G + E+I + + V +VYA +D N + YS + +GN
Sbjct: 3220 VLDINDNPPVFEYREYGAT--VSEDILVGTEVLQVYAASRDIEANAEITYSII--SGNEH 3275
Query: 2661 WEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEP 2720
+ F ID +G + + LD ES Y L + A+D G P + + V + DI+DN P
Sbjct: 3276 GK-FSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTP-SLSDVATVNVNVTDINDNTP 3333
Query: 2721 LFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQ 2780
+F S + E + V V A DAD N+ ++Y I GN+ +F +
Sbjct: 3334 VF------SQDTYTTVISEDAVLEQSVITVM-ADDADGPSNSHIHYSIIDGNQGSSFTID 3386
Query: 2781 P-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDI 2839
P G + V + LDRE + ++ V+AS N S PPR + T V + + D+
Sbjct: 3387 PVRGEVKVTKLLDRETISGYTLTVQASDNGS--PPRVNTTT-----------VNIDVSDV 3433
Query: 2840 NDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFY 2883
ND P F++ Y+ + + VG ++Q++ D D +N F+
Sbjct: 3434 NDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFF 3477
Score = 871 bits (2250), Expect = 0.0
Identities = 826/2962 (27%), Positives = 1343/2962 (45%), Gaps = 281/2962 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLV-FGVSGEEASRFFAVEPDTGVVWLRQPL--DRETK 98
I D VG +T + A D D LV + + FF++ P++GV+ L++ L K
Sbjct: 578 IPRDLGVGEQITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAK 637
Query: 99 SEF-TVEFSVSDHQGVIT------------RKVNIQVGD--------------------- 124
F ++ + +D + T + VN+Q +
Sbjct: 638 VSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQG 697
Query: 125 -----------VNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ 172
VN + P F + P +++ EN PVG+ + +N+TD D G G ++Y+
Sbjct: 698 EVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVS 757
Query: 173 PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLA-IIITDV 229
++ F ID G++ ++ LD ETT Y T+N T D P L +++ D
Sbjct: 758 GGNEDSCFMIDMETGMLKILSPLDRETTDKY--TLNITVYDLGIPQKAAWRLLHVVVVDA 815
Query: 230 QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYI 289
D P F+ Y + E + + + A D+D G + Y+IV+ F++D +
Sbjct: 816 NDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDTDT--FSIDSV 873
Query: 290 SGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFN 349
+GV+ + LDRE H L ++ + + +TV + + D+NDN P F
Sbjct: 874 TGVVNIARPLDRE---LQHEHSLKIEARDQAREEPQLFSTVVV--KVSLEDVNDNPPTFI 928
Query: 350 SSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKA 409
Y V + E G + ++++ D D LG + L+ + +F + K
Sbjct: 929 PPNYRVKVREDLPEGTVI-MWLEAHDPD--LGQSGQVRYSLLDHGEGNFDVD------KL 979
Query: 410 DIRIRVAIPLDYETVDRYDFDLFANESVP----DHVGYAKVKITLINENDNRPIFSQPLY 465
+R+ LD+E Y+ + A + Y +V++ +NEN + P+FS +
Sbjct: 980 SGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVE 1039
Query: 466 NISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDY 523
++ E+ VG+ V+TV A D DA GE+ Y D F + ++TG+I RLD
Sbjct: 1040 KGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLDR 1099
Query: 524 ELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLV 581
E + LT+ A D G + + I V DVNDN P + Y + EN P +V
Sbjct: 1100 ESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVV 1159
Query: 582 RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISV-SRPLDYEQISNGLIYLT 640
++ A D DS N+++ Y I S + G + S++ G+I+ SR LD EQ ++ +T
Sbjct: 1160 QIEAFDPDSSSNDKLMYKITSGNPQGFF---SIHPKTGLITTTSRKLDREQQDEHILEVT 1216
Query: 641 VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT-------VLFL 693
V D G+PP ++ V +++ DENDN P F + Y + + E + +
Sbjct: 1217 VT--DNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHV 1274
Query: 694 NATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEY-ILIVRAV 749
ATD D E I YS+E + F I ++G +++ EY IL ++AV
Sbjct: 1275 IATDKD---EGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRF---SAAGEYDILSIKAV 1328
Query: 750 DGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVT-TVVAVDPDLG 808
D G QK+ ++I + K P +L ++ +S T TV+ DP
Sbjct: 1329 DNG--RPQKSSTTRLHIEWIS--------KPKP---SLEPISFEESFFTFTVMESDPVAH 1375
Query: 809 ENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDR-------ENPDPHEAELMRKIVVSVT 861
G V S++PP + T G +H +D+ P E + + V T
Sbjct: 1376 MIG--VISVEPPGIPLWFDITGGNY-DSHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEAT 1432
Query: 862 DCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEG- 920
D T VF+ ++D ND+ P F + + E I Q+ A+D DE
Sbjct: 1433 DG-----TTTILTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN 1487
Query: 921 --LNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSST 978
+ L S R P+ + + F ++ ++G + T+ +LD E + ++ L V+ D P K +
Sbjct: 1488 KLIYTLQSSRDPLSLKK--FRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRNF 1545
Query: 979 STLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN 1038
+ + ++V D ND P F + Y V E V+ + D D G NAE+ Y I GN
Sbjct: 1546 ARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGN 1605
Query: 1039 VDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
+ F + ++T LDR A Y L+++A D G + +FVT+ D +
Sbjct: 1606 IGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIAD--NA 1663
Query: 1099 RPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGL 1158
P F Y + E + G + + A V Y I GN G+ F I+ +G
Sbjct: 1664 SPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNTGDAFDINPHSGT 1718
Query: 1159 LMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGL 1218
++ + LD E + LI++ N + + ++ V+V+++D ND APVF Q +Y+ L +
Sbjct: 1719 IIT-QKALDFETLPIYTLIIQGTN--MAGLSTNTTVLVHLQDENDNAPVFMQAEYTGL-I 1774
Query: 1219 RETAGIGTSVI-------VVQATDRDSGDGGLVNYRILS-GAEGKFEIDESTGLIITVNY 1270
E+A I + V+ V++A D D L+ Y I+ F ID STG I TV
Sbjct: 1775 SESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLS 1834
Query: 1271 LDYETKTSYMMNVSATDQAPP--FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLAL 1328
LDYE + + V D P F + +V + +++ D F+ YEA++L
Sbjct: 1835 LDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYK 1894
Query: 1329 GTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYT 1386
G +++ V A D+ +Q+ Y + T F +D TG +TVQ Y
Sbjct: 1895 GVKVITVNATDADSSAFSQLIY---SITEGNIGEKFSMDYKTGALTVQNTTQLRSR--YE 1949
Query: 1387 LTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDP 1446
LTV A DG + V I V + ++ +F SAV + E+ + +A + A
Sbjct: 1950 LTVRASDG--RFAGLTSVKINVKESKESHLKFTQDVYSAV-VKENSTEAETLAVITAIGN 2006
Query: 1447 DAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPP 1506
N + + + N F+I T+ + P DRE+ + + + V ++ P
Sbjct: 2007 PI--NEPLFYHIL--NPDRRFKISRTSGVLSTT--GTPFDREQQEAFDVVVEVTEEHKPS 2060
Query: 1507 RKKDHILQVTILDINDNPPV-IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSY 1565
+++V + D NDN PV + P+ V V+ VG + V A DRD G N + Y
Sbjct: 2061 AVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGH--VIRYVTAVDRDSGRNGEVHY 2118
Query: 1566 YITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIV 1625
Y+ E ++ F++ + GEI+ + Y + +D G P SA V +T++
Sbjct: 2119 YLKEHHEH--FQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVIVPITVM 2175
Query: 1626 DENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGT-VTYAIVAGNIVNTFR 1684
N P+F++P Y + E +++ ++ +QA P G V Y+I G+ + F
Sbjct: 2176 --NKAMPVFEKPFYSAEIAESIQ-VHSPVVHVQA----NSPEGLKVFYSITDGDPFSQFT 2228
Query: 1685 IDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTF 1744
I+ + GVI LD+E +H Y L + ATD + V + V+DINDN P F
Sbjct: 2229 INFNTGVINVIAPLDFE-AHPAYKLSIRATDSLT----GAHAEVFVDIIVDDINDNPPVF 2283
Query: 1745 PRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGE--FVISPVEGVLR 1802
+ G V A D DS PN + Y + F + G++
Sbjct: 2284 AQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLIS 2343
Query: 1803 VRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISE 1862
+ + LD E + + + A D GMP LSS ++V + V D+NDN P+ ISE
Sbjct: 2344 LLRT--LDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISE 2401
Query: 1863 NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEY 1922
++P FV V A DADS +L ++I +GN + F I++ TGI+T++ P Y
Sbjct: 2402 HAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSNLHRHALKPFY 2461
Query: 1923 KLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
L +SV D R + + + N + P F ++ Y+ E+ EN+P T L
Sbjct: 2462 SLNLSVSDG------VFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHT----LV 2511
Query: 1983 GPILALDADQDIYAVVTYQLLGA-QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
+ D D IY VTY ++ F IN + T+ +DRE + ++ + L
Sbjct: 2512 MEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK---LDRETPAEKVISVRL 2568
Query: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
+A+D G + + + + DDNDN P F V++ + G SV++V A+D D G N
Sbjct: 2569 MAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSN 2628
Query: 2102 GELVYRIEAGAQ---DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTA 2158
++ Y IEA ++ + I+ ++GVI + I E E + V A D G+
Sbjct: 2629 ADITYAIEADSESVKENLEINKLSGVITTKESLIGLEN-EFFTFFVRAVDNGSPSKESVV 2687
Query: 2159 IVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKD 2218
+V + I P+F P T +V E GT I I A + + + Y +V K
Sbjct: 2688 LVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRA---EHSGTVLYSLV----KG 2740
Query: 2219 DTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAK 2278
+T N++++F ++ +G + ++ ++ E Y+ ++ D V +
Sbjct: 2741 NTPE--SNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQDD----HEMVASVD 2794
Query: 2279 LTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL--- 2335
+++ V D NDN+P F+ + Y I+E G+ +I + A D D G NG V Y+L
Sbjct: 2795 VSIQVKDANDNSPVFES---SPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQS 2851
Query: 2336 --LDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVY-LEI 2392
++++ + +E G + + +D+E+ V ASD+G + + + + +
Sbjct: 2852 QSVEVIESFAINME---TGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTV 2908
Query: 2393 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNF-ALIEYSL--GDGESKFA 2449
D+ND+ P F Y+ V ED P G +I ++ TDADS + Y + GD +FA
Sbjct: 2909 TDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFA 2968
Query: 2450 INPTTGD--IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
+ + +YV LDREK+D+Y+LT A D G +S V ++VLD ND P
Sbjct: 2969 VETIQNEWKVYVKKPLDREKRDNYLLTITATD--GTFSSK-----AIVEVKVLDANDNSP 3021
Query: 2508 QFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTT 2567
K +S ++ E+ G ++ + ATD D N E+TY+L G G E F ++ D+G + T
Sbjct: 3022 VCEKTLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKFKLNPDTGELKT 3081
Query: 2568 QRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREE 2625
PL E+ + L V ATDGG + +L +E DVNDN P F P + + E
Sbjct: 3082 STPLDREEQAVYHLLVRATDGGGRFCQASIVLTLE--DVNDNAPEFSADPYA--ITVFEN 3137
Query: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQA 2685
+ + V ATD D GLN + YS + +A + F I+ +SG+IQ + LDRE QA
Sbjct: 3138 TEPGTLLTRVQATDADAGLNRKILYSLIDSADGQ----FSINELSGIIQLEKPLDRELQA 3193
Query: 2686 VYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGT 2745
VY+L L A D G P + V++ DI+DN P+F G+ TV E GT
Sbjct: 3194 VYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGA------TVSEDILVGT 3247
Query: 2746 LVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVK 2804
V V A D NA + Y I +GNE F + G + ++ +LD E + V+
Sbjct: 3248 EVLQVYAA-SRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVE 3306
Query: 2805 ASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSE 2864
A+ G +P+L VA V V + DIND P F++ YT ++ DA +
Sbjct: 3307 ATD--------GGTPSLSDVAT-----VNVNVTDINDNTPVFSQDTYTTVISEDAVLEQS 3353
Query: 2865 LIQVLALDADIGNNSLVFYSIL 2886
+I V+A DAD +NS + YSI+
Sbjct: 3354 VITVMADDADGPSNSHIHYSII 3375
Score = 871 bits (2250), Expect = 0.0
Identities = 844/2937 (28%), Positives = 1341/2937 (45%), Gaps = 239/2937 (8%)
Query: 12 AWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFG 68
AW L+ + N F +F + +SED V S + Q+ A D D P + +
Sbjct: 804 AWRLLHVVVVDANDNPPEFLQESYF---VEVSEDKEVHSEIIQVEATDKDLGPNGHVTYS 860
Query: 69 VSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDH-----QGVITRKVNIQVG 123
+ + + F+++ TGVV + +PLDRE + E +++ D Q T V + +
Sbjct: 861 IVTDTDT--FSIDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLE 918
Query: 124 DVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF-FAIDS 182
DVNDN PTF Y V++ E+ P GT I + A DPDLG G V YS + F +D
Sbjct: 919 DVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEGNFDVDK 978
Query: 183 ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDM--DPIFINLP 240
G V ++++LD+E Q Y LTV A D+ K LS+ + + + DV + P+F +
Sbjct: 979 LSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFV 1038
Query: 241 YSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLD 300
+ E +P G+ V ++A D+D R I Y+I G+ +F + +GV+ + LD
Sbjct: 1039 EKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLD 1098
Query: 301 RENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITEL 360
RE+ SH + LTV T D+ + I V D+NDNAP+ + Y I E
Sbjct: 1099 REST--SH-YWLTVFAT----DQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMEN 1151
Query: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLD 420
+ ++ + I+ D D + M+++ GN F I P K + + LD
Sbjct: 1152 SPKDVSV-VQIEAFDPDSSSNDKLMYKI-TSGNPQGFFSIHP-----KTGLITTTSRKLD 1204
Query: 421 YETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTS- 478
E D + ++ ++ P A+V + +++ENDN+P F Q Y I L E
Sbjct: 1205 REQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRER 1264
Query: 479 ------VLTVLATDNDAGTFGEVSYFFSDDPD--RFSLDKDTGLIM---LIARLDYELIQ 527
+ V+ATD D G E+SY D + +F ++ TG++ A +Y++
Sbjct: 1265 NARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDI-- 1322
Query: 528 RFTLTIIARDGGGEETTGRVRINVLDVNDNVPT-----FQKDAYVGALRENEPSVTQLVR 582
L+I A D G + + R+++ ++ P+ F++ + + E++P V ++
Sbjct: 1323 ---LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDP-VAHMIG 1378
Query: 583 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVM 642
+ + + PP + + I + + S+FD+ +G G I V++PLD EQ SN LTV
Sbjct: 1379 VISVE---PPGIPLWFDITGGN-YDSHFDVD--KGTGTIIVAKPLDAEQKSN--YNLTVE 1430
Query: 643 AMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR 702
A D L V I+V D ND+ P FS Y V + E+ +L ++A D D
Sbjct: 1431 ATDGTTTILTQ---VFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQDEKN 1487
Query: 703 EYGQESIIYSLEGST------QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
+ +IY+L+ S +FR++ +G + T+ LD E ++ L V D V
Sbjct: 1488 K-----LIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVP-- 1540
Query: 757 QKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS 816
K A + + + D ND+ P + + Y + E S V V A+D D G+N ++YS
Sbjct: 1541 VKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYS 1600
Query: 817 IQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
I+ N + ++ G I+T LDR N ++ ++V TD G PP+ +S
Sbjct: 1601 IESGNIGNSFMIDPVLGSIKTAKE-LDRSNQAEYD------LMVKATDKGSPPMSEITSV 1653
Query: 875 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 934
+FV + D + P F + + E+ E + G + V A V Y + G
Sbjct: 1654 RIFVTIAD--NASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS-----VVYEIKDGNT 1706
Query: 935 RMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD-AGTPTKSSTSTLTIHVLDVNDETP 993
F IN SG ++T LD E + Y L + ++ AG S+ +T+ +H+ D ND P
Sbjct: 1707 GDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGL---STNTTVLVHLQDENDNAP 1763
Query: 994 TFFPAVYNVSVSEDVPREFRVVW-------LNCTDNDVGLNAELSYFITGGNVDGKFSVG 1046
F A Y +SE V+ + D D NA L Y I +V F++
Sbjct: 1764 VFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTYFAID 1823
Query: 1047 YRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
+ TV+ LD E T+ + ++ D G A V V V+D+ND P+F +
Sbjct: 1824 SSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPL 1883
Query: 1107 YEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPL 1166
YEAS+ +G ++ + ATDAD F ++ Y I GN G F + G L
Sbjct: 1884 YEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQ 1943
Query: 1167 DRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGT 1226
R R + L V A + G V + V++ + FTQ YS + ++E +
Sbjct: 1944 LRSR---YELTVRASD---GRFAGLTSVKINVKESKESHLKFTQDVYSAV-VKENSTEAE 1996
Query: 1227 SVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNY-LDYETKTSYMMNVSA 1285
++ V+ A + + Y IL+ + +F+I ++G++ T D E + ++ + V
Sbjct: 1997 TLAVITAIGNPINEP--LFYHILN-PDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEV 2053
Query: 1286 TDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQ 1345
T++ P V + + ++ D A F N Y A + + +G I V A D+
Sbjct: 2054 TEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDRDSGRN 2113
Query: 1346 ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREK-GDFYTLTVVADDGG-PKVDSTVK 1403
Y + F+I + G I+++ + + Y +TVVA DGG P + V
Sbjct: 2114 GEVH---YYLKEHHEHFQIGPL-GEISLKKQFELDTLNKEYLVTVVAKDGGNPAFSAEVI 2169
Query: 1404 VYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNI 1463
V ITV+ N P F+ SA I E V V V+A P+ +V +S+ G+
Sbjct: 2170 VPITVM--NKAMPVFEKPFYSA-EIAESIQVHSPVVHVQANSPEGL---KVFYSITDGD- 2222
Query: 1464 AGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDN 1523
F T N + G + V PLD E Y L + A+D T + + + + DINDN
Sbjct: 2223 --PFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVFV-DIIVDDINDN 2279
Query: 1524 PPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA---FRMDR 1580
PPV Y V+++E GT+VVQVRATD D N +SY + GN + F +D
Sbjct: 2280 PPVFAQQ-SYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMF-GNHSKSHDHFHVDS 2337
Query: 1581 ISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE 1640
+G I+ D E+ + + D G PTLS+ V V + D NDN P+F+Q YE
Sbjct: 2338 STGLISLLRTL-DYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYE 2396
Query: 1641 VLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDY 1700
+ E + ++A D D + Y+I++GN F ID G+IT + L
Sbjct: 2397 ARISEHAPH-GHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGIITLSN-LHR 2454
Query: 1701 EISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP- 1759
Y+L ++ +D S+T V V V N + P F ++ E E+ E P
Sbjct: 2455 HALKPFYSLNLSVSDGV------FRSSTQVHVTVIGGNLHSPAFLQN-EYEVELAENAPL 2507
Query: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIA--FY 1817
V D DSG G V Y I++ F I+ + + K LDRET A
Sbjct: 2508 HTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLEK---LDRETPAEKVI 2564
Query: 1818 NLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASD 1877
++ + A+D G T V + + D NDN P + I ++ + V VLASD
Sbjct: 2565 SVRLMAKDAGGKVAFCT--VNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASD 2622
Query: 1878 ADSGCNARLTFNITAGNR--ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENP 1935
AD G NA +T+ I A + + IN +G++T L + + DN
Sbjct: 2623 ADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGSP- 2681
Query: 1936 RIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIY 1995
++ L+ + + P F++ Y V E+ P GT + ++ A + +Y
Sbjct: 2682 --SKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIR----AEHSGTVLY 2735
Query: 1996 AVVTYQLLGA-QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL-LAEDIGLLNSTA 2053
++V + + F I+ +G + + +D E +L +D + ++
Sbjct: 2736 SLVKGNTPESNRDESFVIDRQSGRLKLEKS--LDHETTKWYQFSILARCTQDDHEMVASV 2793
Query: 2054 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ 2113
+ I + D NDN P F + ++EN P G V+Q+ A+D DSG NG+++Y ++
Sbjct: 2794 DVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQS 2853
Query: 2114 ----DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGT-VPLSGTAIVTILIDDIN 2168
+ F I++ TG I +D E++++Y++ VVA+D G + LS TAIV + + D+N
Sbjct: 2854 VEVIESFAINMETGWITTLKE-LDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVN 2912
Query: 2169 DSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD---LNPKLEYHIVGIVAKDDTDRLVP 2225
DS P F I +V E G VIA ++ D D +N ++ Y I G
Sbjct: 2913 DSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITG-----------G 2961
Query: 2226 NQEDAFAVNI--NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNV 2283
+ FAV N V VK P++RE Y +T++ D A + V V
Sbjct: 2962 DPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFS--------SKAIVEVKV 3013
Query: 2284 LDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGY 2343
LD NDN+P + T Y + I E PG ++ ++A D D N +TYTLL +
Sbjct: 3014 LDANDNSPVCEK---TLYSDTIPEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEKF 3070
Query: 2344 VQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFD 2403
D+ G++ + +D EE + VRA+D G R + + L + D+NDN P F
Sbjct: 3071 KLNPDT--GELKTSTPLDREEQAVYHLLVRATDGGG--RFCQASIVLTLEDVNDNAPEFS 3126
Query: 2404 QPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG-ESKFAINPTTGDIYVLSS 2462
Y VFE+ GT++ V ATDAD+G I YSL D + +F+IN +G I +
Sbjct: 3127 ADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQLEKP 3186
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENE 2522
LDRE + Y L+ A D R + V++ VLD+ND P F ++ +V E+
Sbjct: 3187 LDRELQAVYTLSLKAVDQG---LPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDI 3243
Query: 2523 PAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
GT V+ + A +D N E+TYS+ G F +D +G V L +S ++ L
Sbjct: 3244 LVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYL 3303
Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
TV ATDGG P L + V V D+NDN PVF + T+ I E+ L +V V A D
Sbjct: 3304 TVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTV--ISEDAVLEQSVITVMADD 3361
Query: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 2699
D N + YS + GN+ F IDP+ G ++ + LDRE+ + Y+L + ASD G P
Sbjct: 3362 ADGPSNSHIHYSIID--GNQG-SSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSP 3418
Query: 2700 VPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEG 2759
P + + + D++DN P+F R Y ++ + E+ P G V + D D
Sbjct: 3419 -PRVNTTTVNIDVSDVNDNAPVFSRG-----NYSVI-IQENKPVGFSVLQLV-VTDEDSS 3470
Query: 2760 PNAIVYYF-IAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPS 2818
N ++F I GN+EK F + P G LL + R+ + + VK + N
Sbjct: 3471 HNGPPFFFTIVTGNDEKAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADN--------GK 3522
Query: 2819 PTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADI 2875
P L + LT ++RV+ E I PP E + + G + ++ A D D+
Sbjct: 3523 PQL---SSLTYIDIRVIEESI--YPPAILPLEIFITSSGEEYSGGVIGKIHATDQDV 3574
Score = 853 bits (2204), Expect = 0.0
Identities = 852/3035 (28%), Positives = 1375/3035 (45%), Gaps = 306/3035 (10%)
Query: 5 VATSCHVAWLLVLISGCWGQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD--- 61
V TS A VL+ G + P FT + E+ P+G++V L A D D
Sbjct: 438 VTTSDRKASTKVLVK-VLGANSNPPEFTQTAYKA--AFDENVPIGTTVMSLSAVDPDEGE 494
Query: 62 NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE-FTVEFSVSDHQGVITRKVN- 119
N + + ++ F A++ TG V + LD E +T+ SD R+V
Sbjct: 495 NGYVTYSIANLNHVPF-AIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEV 553
Query: 120 ---IQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ 176
I + ++NDN P F IP + VG I V+A D D V Y + ++
Sbjct: 554 LATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD--ELQLVQYQIEAGNE 611
Query: 177 --FFAIDSARGIVTVIRELDY---ETTQAYQLTVNATDQDK-TRPL---------STLAN 221
FF+++ G++++ R L + L + ATD + PL L N
Sbjct: 612 LDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVN 671
Query: 222 LAIIITDVQDM-----------------DPIFIN--------------LPYSTNIYEHSP 250
L T V M + IF + LP + E+ P
Sbjct: 672 LQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQP 731
Query: 251 PGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGF 310
G++V + + D D G + Y + GN +S F +D +G+L + LDRE + +
Sbjct: 732 VGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRET---TDKY 788
Query: 311 ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370
L + +L P A +++V+D NDN PEF Y V ++E +V +
Sbjct: 789 TLNITVYDLG---IPQKAA-WRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEI--- 841
Query: 371 IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD 430
IQV D++LG N +V + I S T V + +A PLD E +
Sbjct: 842 IQVEATDKDLGPNGHVTYSIVTDTDTFSIDSVTGV-------VNIARPLDRELQHEHSLK 894
Query: 431 LFANESV---PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
+ A + P VK++L + NDN P F P Y + + E++ GT ++ + A D
Sbjct: 895 IEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDP 954
Query: 488 DAGTFGEVSYFFSDDPD-RFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---ET 543
D G G+V Y D + F +DK +G + ++ +LD+E Q + LT+ A+D G +
Sbjct: 955 DLGQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSS 1014
Query: 544 TGRVRINVLDVNDNV--PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
T V + V+DVN+N+ P F G ++E+ P + ++ + A DED+ + +I YSI
Sbjct: 1015 TCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIR 1074
Query: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
S G + + E GVI S LD E S+ +LTV A D G PL+S + + IEV
Sbjct: 1075 DGSGVGVF---KIGEETGVIETSDRLDRESTSH--YWLTVFATDQGVVPLSSFIEIYIEV 1129
Query: 662 FDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ-- 718
D NDN P S+P Y+ ++EN +V+ + A D D S + ++Y + G+ Q
Sbjct: 1130 EDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSS---SNDKLMYKITSGNPQGF 1186
Query: 719 FRINARSGEITTTSL-LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
F I+ ++G ITTTS LDRE + E+IL V D G K+ IA V + +LD NDN P
Sbjct: 1187 FSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNG--SPPKSTIARVIVKILDENDNKPQ 1244
Query: 778 WKDAPYYINLVEMTPPDSDVTT-------VVAVDPDLGENGTLVYSIQPPNKF--YSLNS 828
+ Y I L E PD + V+A D D G N + YSI+ N+ + +
Sbjct: 1245 FLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEP 1304
Query: 829 TTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATV-FVNLLDLNDND 887
TG + + E + + D GRP +T+ + +++ +
Sbjct: 1305 KTGVVSSKRFSAAGEYDI---------LSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEP 1355
Query: 888 PTFQNLPFVAEVLEGIPA----GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSS 943
+F+ F V+E P GV + I L + G G F ++
Sbjct: 1356 ISFEESFFTFTVMESDPVAHMIGVISVEPPGIPLWFDITG--------GNYDSHFDVDKG 1407
Query: 944 SGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVS 1003
+G ++ LD E+ + Y L V A+D T + + + I V+D ND P F + Y V
Sbjct: 1408 TGTIIVAKPLDAEQKSNYNLTVEATDG---TTTILTQVFIKVIDTNDHRPQFSTSKYEVV 1464
Query: 1004 VSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVD---GKFSVGYRDAVVRTVVGLDR 1060
+ ED E ++ ++ D D +L Y + KF + + T LD
Sbjct: 1465 IPEDTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDH 1522
Query: 1061 ETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHS 1120
E + L + D KR+ A + V V D ND+ P F SSY+ V E G
Sbjct: 1523 EAVHQHTLTVMVRDQDVPVKRNF--ARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSV 1580
Query: 1121 ILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEA 1180
+LQ+ A D D+G+ V Y I GN GN+F I G + + + LDR + + L+V+A
Sbjct: 1581 VLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSI-KTAKELDRSNQAEYDLMVKA 1639
Query: 1181 YNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGD 1240
+ PM V ++V ++ +P FT ++YS + L ET IG+ V +V A + S
Sbjct: 1640 TDKGSPPMSEITSVRIFVTIADNASPKFTSKEYS-VELSETVSIGSFVGMVTAHSQSS-- 1696
Query: 1241 GGLVNYRILSGAEGK-FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSV 1299
V Y I G G F+I+ +G IIT LD+ET Y + + T+ A +V
Sbjct: 1697 ---VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLSTN--TTV 1751
Query: 1300 YITLLNELDEAVQFSNASYEAAILENLALGTEIVR-------VQAYSIDNLNQITYRFNA 1352
+ L +E D A F A Y I E+ ++ + ++ ++A D + ++
Sbjct: 1752 LVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHI 1811
Query: 1353 YTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV-VADDGGPKV--DSTVKVYITVL 1409
F ID+ TG I +D E+ + TV V D G P++ + V + V+
Sbjct: 1812 -VEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVI 1870
Query: 1410 DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI 1469
D ND P F A S+ G +V TV A D D+ + Q+++S+ GNI F +
Sbjct: 1871 DINDCPPVFAKPLYEA-SLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSM 1929
Query: 1470 VTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIES 1529
+ G + V Y L V ASD +T + IN V ES
Sbjct: 1930 ---DYKTGALTVQNTTQLRS--RYELTVRASD--------GRFAGLTSVKIN----VKES 1972
Query: 1530 PFG--------YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRI 1581
Y+ V EN + + A I N L Y+I N D F++ R
Sbjct: 1973 KESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPI--NEPLFYHIL--NPDRRFKISRT 2028
Query: 1582 SGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ-PHYE 1640
SG ++T P DRE+Q + +V V +E P+ A V V + D+NDNAP+F P+Y
Sbjct: 2029 SGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYA 2088
Query: 1641 VLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDY 1700
V+ + + + + A+D D G NG V Y + + F+I +G I+ K+ +
Sbjct: 2089 VVKVD--TEVGHVIRYVTAVDRDSGRNGEVHYYLKEHH--EHFQIGP-LGEISLKKQFEL 2143
Query: 1701 EISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPG 1760
+ + Y + V A D + V+V + +N +P F E PF E
Sbjct: 2144 DTLNKEYLVTVVAKD-----GGNPAFSAEVIVPITVMNKAMPVF----EKPFYSAEIAES 2194
Query: 1761 PRVWTFLAHDRDSGPNG-QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNL 1819
+V + + H + + P G +V YSI DGDP +F I+ GV+ V LD E Y L
Sbjct: 2195 IQVHSPVVHVQANSPEGLKVFYSITDGDPFSQFTINFNTGVINVI--APLDFEAHPAYKL 2252
Query: 1820 TICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
+I A D + + + V I V DINDN PV +T+SE S + + V V A+D+D
Sbjct: 2253 SIRATD-SLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSD 2311
Query: 1880 SGCNARLTFNITAGNRERA---FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPR 1936
S N +++ + GN ++ F ++++TG++++ R LD E+ ++ + + D P
Sbjct: 2312 SEPNRGISYQMF-GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGM-PT 2369
Query: 1937 IARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYA 1996
++ ++ + ++D NDN PLF + Y+A + E++P G +T + A DAD
Sbjct: 2370 LSSDV--IVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFVTCVK----AYDADSSDID 2423
Query: 1997 VVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHL 2055
+ Y +L G F I+S+TG++T+ + + R A P L L+ G+ S+ +
Sbjct: 2424 KLQYSILSGNDHKHFVIDSATGIITLSN---LHRHALKP--FYSLNLSVSDGVFRSSTQV 2478
Query: 2056 LITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQD 2114
+T++ N + P F V L EN P V++V TD DSG+ G + Y I A+D
Sbjct: 2479 HVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKD 2538
Query: 2115 RFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF 2174
RF I+ + + + ++ + ++A D G T V +++ D ND+ P+F
Sbjct: 2539 RFYINERGQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCT--VNVILTDDNDNAPQF 2596
Query: 2175 LNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFA 2232
V++ SA GT + + A D D N + Y I + D++ + N E
Sbjct: 2597 RATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAI-----EADSESVKENLE---- 2647
Query: 2233 VNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292
+N +G + K + + + +DN S E V V V +L P+
Sbjct: 2648 INKLSGVITTKESLIGLENEFFTFFVRAVDNGSPSKESVVLV-----YVKILPPEMQLPK 2702
Query: 2293 FKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE----D 2348
F +Y + E GT + + A +G V Y+L+ P + E D
Sbjct: 2703 FSE---PFYTFTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVID 2754
Query: 2349 SSAGKVIANRTVDYEEVHWLNFTVRAS-DNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
+G++ +++D+E W F++ A A + V +++ D NDN+P+F+ Y
Sbjct: 2755 RQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPY 2814
Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGES-----KFAINPTTGDIYVLSS 2462
+ + E++P G+ ++ + A+DADSG + YSL +S FAIN TG I L
Sbjct: 2815 EAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKE 2874
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENE 2522
LD EK+D+Y + +A D+ + + ++ V + V DVND P+F+ + +V E++
Sbjct: 2875 LDHEKRDNYQIKVVASDHGEKI---QLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDD 2931
Query: 2523 PAGTSVITMMATDQD-EGPNGELTYSLEGP---GVEAFHVDMDSGLVTTQRPL--QSYEK 2576
P G + + TD D E N ++TY + G G A + V ++PL + +
Sbjct: 2932 PQGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDN 2991
Query: 2577 FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVY 2636
+ LT+ ATDG ++ V+V+D NDN PV + I E++ + ++
Sbjct: 2992 YLLTITATDG---TFSSKAIVEVKVLDANDNSPVCEKTLYSDT--IPEDVLPGKLIMQIS 3046
Query: 2637 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDL 2696
ATD D N + Y+ L + + F ++P +G ++T+ LDRE QAVY L++ A+D
Sbjct: 3047 ATDADIRSNAEITYTLLGSGAEK----FKLNPDTGELKTSTPLDREEQAVYHLLVRATDG 3102
Query: 2697 GQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDA 2756
G + + LED++DN P F P +TV E++ GTL+ V A DA
Sbjct: 3103 GGRF---CQASIVLTLEDVNDNAPEFSADPYA------ITVFENTEPGTLLTRVQ-ATDA 3152
Query: 2757 DEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRG 2816
D G N + Y + + + + G + + + LDRE +A+++ +KA PR
Sbjct: 3153 DAGLNRKILYSLIDSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGL---PRR 3209
Query: 2817 PSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIG 2876
+ T ++ + DIND PP F EY A V+ D VG+E++QV A DI
Sbjct: 3210 LTATGTVIVSVL---------DINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIE 3260
Query: 2877 NNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMD 2911
N+ + YSI++ + + DS+ G VF + ++D
Sbjct: 3261 ANAEITYSIISGNEHGKFSIDSK-TGAVFIIENLD 3294
Score = 819 bits (2115), Expect = 0.0
Identities = 791/2905 (27%), Positives = 1284/2905 (44%), Gaps = 276/2905 (9%)
Query: 93 LDRETKSEFT-VEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
L+RE K +T + ++ + V R KV +QV D ND P F YSV +PENT + T
Sbjct: 108 LNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTS 167
Query: 151 IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
I V+ATD D+G G YSF+ + FAI G++ + LDY T+ Y++ + A D+
Sbjct: 168 IARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEILAADR 227
Query: 211 DK----TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
+ +S++A L + I + P+ + S + + P I+T D D+G
Sbjct: 228 GMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP---AYAIVTVDDCDQG 284
Query: 267 RPRGI-GYTIVSGN------TNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
I +IV+G+ T F V + G+ +P G+ LT+ +
Sbjct: 285 ANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPF---GYNLTL---QA 338
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDEN 379
D TP + ++ +F Y I+E A + + ++ + +
Sbjct: 339 KDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPV-VMVKAIPAYSH 397
Query: 380 LGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVP 438
L ++ T + K + + E V R F E +
Sbjct: 398 L----------------RYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTS 441
Query: 439 DHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYF 498
D KV + ++ N N P F+Q Y + ENV +GT+V+++ A D D G G V+Y
Sbjct: 442 DRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENGYVTYS 501
Query: 499 FSD-DPDRFSLDKDTGLIMLIARLDYELIQR-FTLTIIARDGG---GEETTGRVRINVLD 553
++ + F++D TG + LDYEL+ R +TL I A D G E I + +
Sbjct: 502 IANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNN 561
Query: 554 VNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDIS 613
+NDN P F+K G + + Q+ + A D D + Y I + + + S
Sbjct: 562 LNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE--LQLVQYQIEAGNELDFF---S 616
Query: 614 LYEGYGVISVSRPL-DYEQISNGLIYLTVMAMDAGN--PPL--NSTVPVTIEV------- 661
L GV+S+ R L D L + A D N PL N TV + ++
Sbjct: 617 LNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEE 676
Query: 662 ---------------------------FDE---NDNPPTF-SKPAYFVSVVENIMAGATV 690
FD N + P F S + V EN G++V
Sbjct: 677 TGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSV 736
Query: 691 LFLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVR 747
+F+N+TDLD ++Y++ G + F I+ +G + S LDRET +Y L +
Sbjct: 737 IFMNSTDLDTG---FNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNIT 793
Query: 748 AVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDL 807
D G+ QK +++ ++D NDN P + Y++ + E S++ V A D DL
Sbjct: 794 VYDLGI--PQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDL 851
Query: 808 GENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867
G NG + YSI +S++S TG + LDRE H + + D R
Sbjct: 852 GPNGHVTYSIVTDTDTFSIDSVTGVVNIARP-LDRELQHEH------SLKIEARDQAREE 904
Query: 868 LKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927
+ S+ V V+L D+NDN PTF + +V E +P G I + A D D G +G V Y
Sbjct: 905 PQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRY 964
Query: 928 RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTK-SSTSTLTIHVL 986
+ + +F ++ SG V +LD E+ Y L V A D G P SST + + V+
Sbjct: 965 SL-LDHGEGNFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVV 1023
Query: 987 DVND--ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFS 1044
DVN+ P F V +V ED P V+ ++ D D + E+ Y I G+ G F
Sbjct: 1024 DVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFK 1083
Query: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
+G V+ T LDRE+T+ Y L + A D G V + +++ V DVNDN P +
Sbjct: 1084 IGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPL--SSFIEIYIEVEDVNDNAPQTSE 1141
Query: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPR 1164
Y + E+ P+ S++Q++A D D ++ Y+I GN F IH GL+ R
Sbjct: 1142 PVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSR 1201
Query: 1165 PLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYS-RLGLRETAG 1223
LDRE+ H+L V ++ P + RVIV + D ND P F Q+ Y RL RE
Sbjct: 1202 KLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPD 1261
Query: 1224 IGTS-----VIVVQATDRDSGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYL---DYE 1274
+ + V ATD+D G ++Y I G E GKF I+ TG++ + + +Y+
Sbjct: 1262 RERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYD 1321
Query: 1275 TKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---EAVQFSNASYEAAILEN--LALG 1329
++++ A D P ++I +++ E + F + + ++E+ +A
Sbjct: 1322 -----ILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHM 1376
Query: 1330 TEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV 1389
++ V+ I I T + F +D TG I V +D E+ Y LTV
Sbjct: 1377 IGVISVEPPGIPLWFDI-------TGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNLTV 1429
Query: 1390 VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAG 1449
A DG + +V+I V+D ND+ P+F TS V IPED + + A D D
Sbjct: 1430 EATDGTTTI--LTQVFIKVIDTNDHRPQFS-TSKYEVVIPEDTAPETEILQISAVDQD-- 1484
Query: 1450 SNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKK 1509
+++++L S + + + + G ++ + LD E + + L V+ D+ P ++
Sbjct: 1485 EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVKRN 1544
Query: 1510 DHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE 1569
+ V + D ND+ P + Y V E+ G+ V+QV A D+D G N+ + Y I
Sbjct: 1545 FARIVVNVSDTNDHAPWFTAS-SYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSIES 1603
Query: 1570 GNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEND 1629
GN +F +D + G I T DR Q+ Y L+ D+G+P +S T V + + ++
Sbjct: 1604 GNIGNSFMIDPVLGSIKT-AKELDRSNQAEYDLMVKATDKGSPPMSEITSVRIFVTIADN 1662
Query: 1630 NAPMFQQPHYEVLLDEGPDTLN-TSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRH 1688
+P F Y V L E + ++T + +V Y I GN + F I+ H
Sbjct: 1663 ASPKFTSKEYSVELSETVSIGSFVGMVTAHS-------QSSVVYEIKDGNTGDAFDINPH 1715
Query: 1689 MGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPR-D 1747
G I K LD+E + YTLI+ T+ L++ TTVLV++ D NDN P F + +
Sbjct: 1716 SGTIITQKALDFE-TLPIYTLIIQGTNMA-----GLSTNTTVLVHLQDENDNAPVFMQAE 1769
Query: 1748 YEGPFE--------VTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEG 1799
Y G V + P V A D D N + Y I++ F I G
Sbjct: 1770 YTGLISESASINSVVLTDRNVPLV--IRAADADKDSNALLVYHIVEPSVHTYFAIDSSTG 1827
Query: 1800 VLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTML--VGIRVLDINDNDPVLLNLPMN 1857
+ + LD E + ++ T+ D G P L + V + V+DIND PV
Sbjct: 1828 A--IHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVFAKPLYE 1885
Query: 1858 ITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRE 1917
++ + V V A+DADS ++L ++IT GN F ++ TG +TV
Sbjct: 1886 ASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQNTTQLR 1945
Query: 1918 RIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTP 1977
Y+LT+ D R A + I + + ++H FT+ Y A V ENS
Sbjct: 1946 --SRYELTVRASDG----RFA--GLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAET 1997
Query: 1978 LTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPIL 2037
L V+ I + Y +L F I+ ++GV++ +G DRE
Sbjct: 1998 LAVITA------IGNPINEPLFYHILNPDR-RFKISRTSGVLST-TGTPFDRE--QQEAF 2047
Query: 2038 ELLLLAEDIGLLNSTAHLLITIL--DDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATD 2095
++++ + ++ AH+++ ++ D NDN P F + + G + VTA D
Sbjct: 2048 DVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVD 2107
Query: 2096 EDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLS 2155
DSG NGE+ Y ++ + F I + + +D +E Y +TVVA D G S
Sbjct: 2108 RDSGRNGEVHYYLKE-HHEHFQIGPLGEISLKKQFELDTLNKE-YLVTVVAKDGGNPAFS 2165
Query: 2156 GTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIV 2215
IV I + +N + P F P + + ES + + + ++ A + K+ Y I
Sbjct: 2166 AEVIVPITV--MNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE-GLKVFYSIT--- 2219
Query: 2216 AKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2275
D D F +N NTG + V +P++ E Y++++ D S++
Sbjct: 2220 ---DGDPF-----SQFTINFNTGVINVIAPLDFEAHPAYKLSIRATD--------SLTGA 2263
Query: 2276 NAKLTVNVL--DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTY 2333
+A++ V+++ D+NDN P F Y + E + GT+++ V A D D N ++Y
Sbjct: 2264 HAEVFVDIIVDDINDNPPVFAQ---QSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISY 2320
Query: 2334 TLLDLVPPGYVQLE-DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEI 2392
+ + DSS G + RT+DYE+ VRA D G P ++++ V +++
Sbjct: 2321 QMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDV 2380
Query: 2393 VDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAI 2450
D+NDN P+F+Q Y+ + E P G + V A DADS + ++YS+ G+ F I
Sbjct: 2381 TDLNDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVI 2440
Query: 2451 NPTTGDIYVLSSLDREK-KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF 2509
+ TG I LS+L R K Y L V+ +S QV + V+ N P F
Sbjct: 2441 DSATG-IITLSNLHRHALKPFYSLNL-------SVSDGVFRSSTQVHVTVIGGNLHSPAF 2492
Query: 2510 SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP-GVEAFHVDMDSGLVTTQ 2568
+ ++ + EN P T V+ + TD D G G +TY + + F+++ + T +
Sbjct: 2493 LQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYINERGQIFTLE 2552
Query: 2569 ---RPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREE 2625
R + + S+ ++A D G + T ++ + D NDN P F ++I
Sbjct: 2553 KLDRETPAEKVISVRLMAKDAGGKVAFCTVNVI--LTDDNDNAPQF--RATKYEVNIGSS 2608
Query: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQA 2685
++V +V A+D DEG N + Y+ ++ E I+ +SG+I T + L
Sbjct: 2609 AAKGTSVVKVLASDADEGSNADITYA-IEADSESVKENLEINKLSGVITTKESLIGLENE 2667
Query: 2686 VYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGT 2745
++ + A D G P E++ + V + P ++ PK S + TV E P GT
Sbjct: 2668 FFTFFVRAVDNGSP-SKESVVLVYVKI------LPPEMQLPKFSEPFYTFTVSEDVPIGT 2720
Query: 2746 LVGNVTGAVDADEGPNAIVYYFIAA----GNEEKNFHL-QPDGCLLVLRDLDREREAIFS 2800
+ + E ++Y + N +++F + + G L + + LD E +
Sbjct: 2721 EIDLIRA-----EHSGTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQ 2775
Query: 2801 FIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAK 2860
F + A R ++VA + +V + ++D ND P F + Y A + +
Sbjct: 2776 FSILA---------RCTQDDHEMVASV---DVSIQVKDANDNSPVFESSPYEAFIVENLP 2823
Query: 2861 VGSELIQVLALDADIGNNSLVFYSI 2885
GS +IQ+ A DAD G N V YS+
Sbjct: 2824 GGSRVIQIRASDADSGTNGQVMYSL 2848
Score = 769 bits (1985), Expect = 0.0
Identities = 791/2831 (27%), Positives = 1265/2831 (44%), Gaps = 289/2831 (10%)
Query: 236 FINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG-IGYTIVSGNTNSIF-ALDYISG-- 291
F +L Y+ + E+S T V + P + Y IVSG++ ++F A +YI G
Sbjct: 34 FTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDF 93
Query: 292 ----VLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE 347
+ T G N + L VK E N ++ T + V+D ND P
Sbjct: 94 CFLRIRTKGGNTAILNREVKDHYTLIVKALEKN-----TNVEARTKVRVQVLDTNDLRPL 148
Query: 348 FNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
F+ + YSV++ E + ++ +V D ++G N F Y + + F I PTS
Sbjct: 149 FSPTSYSVSLPENTAIRTSIA---RVSATDADIGTNGEF-YYSFKDRTDMFAIHPTSGV- 203
Query: 408 KADIRIRVAIPLDYETVDRYDFDLFANESVPDHVG------YAKVKITLINENDNRPIFS 461
I + LDY Y+ ++ A + G AK+ + + N+ P+ +
Sbjct: 204 -----IVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVIT 258
Query: 462 QPLYNISLYENVTVGTSVLTVLATDNDA-GTFGEVSYFFSDDPDRFSLDKDTG-----LI 515
+ S + +++TV D A G +S D +F + +
Sbjct: 259 AVTLSPSELDR-DPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKV 317
Query: 516 MLIARLDYELIQ-RFTLTIIARDGGGEETTGRVRINVL---DVNDNVPTFQKDAYVGALR 571
I +D++ + LT+ A+D G V++ + F+KD Y +
Sbjct: 318 KAIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEIS 377
Query: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ 631
E P T +V ++A P + + Y S + SL G+IS+ P+ +Q
Sbjct: 378 EFAPPNTPVVMVKAI----PAYSHLRYVFKSTPGKAKF---SLNYNTGLISILEPVKRQQ 430
Query: 632 ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVL 691
++ + +T A + V ++V N NPP F++ AY + EN+ G TV+
Sbjct: 431 AAHFELEVTTSDRKA-------STKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVM 483
Query: 692 FLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSE-YILIVRAVD 750
L+A D D E G + + F I+ +G ++T+ LD E Y L +RA D
Sbjct: 484 SLSAVDPDEG-ENGYVTYSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASD 542
Query: 751 GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD----SDVTTVVAVDPD 806
G+ + ++ + ITL ++NDN P ++ IN P D +TTV A+D D
Sbjct: 543 WGLPYRREVEVLAT-ITLNNLNDNTPLFEK----INCEGTIPRDLGVGEQITTVSAIDAD 597
Query: 807 LGENGTLVYSIQPPNK--FYSLNSTTGKIRTTHAMLD--------------RENPDPHEA 850
E + Y I+ N+ F+SLN +G + +++D + +
Sbjct: 598 --ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFAT 655
Query: 851 ELMRKIVVSVT---------DCGRPPLKATSSAT------------VFVNLLDLNDNDPT 889
L I V+ + + G + A +F + +N + P
Sbjct: 656 PLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQ 715
Query: 890 FQN-LPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVV 948
F++ LP +V E P G S+ + + DLD G NG + Y + G F+I+ +G++
Sbjct: 716 FRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLK 775
Query: 949 TTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDV 1008
+ LDRE +Y L + D G P K++ L + V+D ND P F Y V VSED
Sbjct: 776 ILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDK 835
Query: 1009 PREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYML 1068
++ + TD D+G N ++Y I FS+ VV LDRE + L
Sbjct: 836 EVHSEIIQVEATDKDLGPNGHVTYSIVTDT--DTFSIDSVTGVVNIARPLDRELQHEHSL 893
Query: 1069 ILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATD 1128
+EA D + T V V++ DVNDN P F+ +Y V ED+PEG I+ L+A D
Sbjct: 894 KIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHD 953
Query: 1129 ADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGP- 1187
D G+ G+V Y +L GN F + +G + R + LD E+ + L V A D G
Sbjct: 954 PDLGQSGQVRYSLLDHGEGN-FDVDKLSGAV-RIVQQLDFEKKQVYNLTVRA--KDKGKP 1009
Query: 1188 --MRSSVRVIVYVEDINDEA--PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGL 1243
+ S+ V V V D+N+ PVF+ + ++E A +G+ V+ V A D D+ G
Sbjct: 1010 VSLSSTCYVEVEVVDVNENLHPPVFSSF-VEKGTVKEDAPVGSLVMTVSAHDEDARRDGE 1068
Query: 1244 VNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYIT 1302
+ Y I G+ G F+I E TG+I T + LD E+ + Y + V ATDQ F +YI
Sbjct: 1069 IRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIE 1128
Query: 1303 LLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALF 1362
+ + D A Q S Y I+EN +V+++A+ D+ + + TS + F
Sbjct: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKI-TSGNPQGFF 1187
Query: 1363 KIDAITGVITVQGL-VDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDF 1420
I TG+IT +DRE+ D + L V V D+G P + +V + +LDENDN P+F
Sbjct: 1188 SIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKILDENDNKPQF-L 1246
Query: 1421 TSDSAVSIPE-DCPVGQRVAT------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTN 1473
+ +PE + P +R A V A D D G N ++ +S+ GN G F I
Sbjct: 1247 QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFI---E 1303
Query: 1474 DSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIE----- 1528
G V R E D IL + A D G P +K ++ I I+ P +E
Sbjct: 1304 PKTGVVSSKRFSAAGEYD--ILSIKAVDNGRP--QKSSTTRLHIEWISKPKPSLEPISFE 1359
Query: 1529 -SPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIAT 1587
S F + V ++ V V+ V GI L + IT GN D F +D+ +G I
Sbjct: 1360 ESFFTFTVMESDPVAHMIGVISVEPP----GIP--LWFDITGGNYDSHFDVDKGTGTIIV 1413
Query: 1588 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGP 1647
P D E++S Y+L D GT T+ T V++ ++D ND+ P F YEV++ E
Sbjct: 1414 AK-PLDAEQKSNYNLTVEATD-GTTTI--LTQVFIKVIDTNDHRPQFSTSKYEVVIPE-- 1467
Query: 1648 DTL-NTSLITIQALDLDEGPNGTVTYAIVAGN---IVNTFRIDRHMGVITAAKELDYEIS 1703
DT T ++ I A+D DE + Y + + + FR+D G + +++LD+E
Sbjct: 1468 DTAPETEILQISAVDQDE--KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAV 1525
Query: 1704 HGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRV 1763
H ++TL V DQ + ++VNV+D ND+ P F G V
Sbjct: 1526 H-QHTLTVMVRDQDVPVKRNFAR---IVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVV 1581
Query: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823
A D+D G N +V YSI G+ F+I PV G ++ K ELDR A Y+L + A
Sbjct: 1582 LQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAK--ELDRSNQAEYDLMVKA 1639
Query: 1824 RDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCN 1883
D+G PP+S V I V ++ P + ++ +SE + SFV V A S
Sbjct: 1640 TDKGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAHSQSS--- 1696
Query: 1884 ARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYD 1943
+ + I GN AF IN +G + + LD E +P Y L I +
Sbjct: 1697 --VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTN-----MAGLSTNT 1749
Query: 1944 LLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTP-LTVLNGPIL--ALDADQDIYAVVTY 2000
+L+ L DENDN P+F ++ Y + E++ + LT N P++ A DAD+D A++ Y
Sbjct: 1750 TVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVY 1809
Query: 2001 QLLGAQ-SGLFDINSSTGVV-TVRSGVIIDREAFSPPILELLLLAEDIG----LLNSTAH 2054
++ F I+SSTG + TV S +D E S I + D+G A+
Sbjct: 1810 HIVEPSVHTYFAIDSSTGAIHTVLS---LDYEETS--IFHFTVQVHDMGTPRLFAEYAAN 1864
Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI-EAGAQ 2113
+ + ++D ND P F+ LL G V+ V ATD DS +L+Y I E
Sbjct: 1865 VTVHVIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIG 1924
Query: 2114 DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPE 2173
++F + TG + V N T + + Y LTV A+D +G V I + + +S +
Sbjct: 1925 EKFSMDYKTGALTVQNTT---QLRSRYELTVRASDGR---FAGLTSVKINVKESKESHLK 1978
Query: 2174 FLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAV 2233
F + + V E++ +A ITAI + +N L YHI+ N + F +
Sbjct: 1979 FTQDVYSAVVKENSTEAETLAVITAIGNPINEPLFYHIL-------------NPDRRFKI 2025
Query: 2234 NINTGSVMVK-SPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292
+ +G + +P +RE ++V + V + + +V + + V V D NDN P
Sbjct: 2026 SRTSGVLSTTGTPFDREQQEAFDVVVEVTEE-----HKPSAVAHVVVKVIVEDQNDNAPV 2080
Query: 2293 FKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLD------LVPPGYVQL 2346
F + YY + G + V AVD D G NG V Y L + + P G + L
Sbjct: 2081 F--VNLPYYAV-VKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKEHHEHFQIGPLGEISL 2137
Query: 2347 EDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPS 2406
+ K T++ E + TV A D G+P +AE+ V + ++ N P+F++P
Sbjct: 2138 K-----KQFELDTLNKEYL----VTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPF 2186
Query: 2407 YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE--SKFAINPTTGDIYVLSSLD 2464
Y + E + V + ++ V A + + YS+ DG+ S+F IN TG I V++ LD
Sbjct: 2187 YSAEIAESIQVHSPVVHVQANSPEG---LKVFYSITDGDPFSQFTINFNTGVINVIAPLD 2243
Query: 2465 REKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPA 2524
E Y L+ A D+ + E V +++ D+ND P F++ ++ ++ E
Sbjct: 2244 FEAHPAYKLSIRATDS---LTGAHAEVFVDIIVD--DINDNPPVFAQQSYAVTLSEASVI 2298
Query: 2525 GTSVITMMATDQDEGPNGELTYSLEGPGVEA---FHVDMDSGLVTTQRPL--QSYEKFSL 2579
GTSV+ + ATD D PN ++Y + G ++ FHVD +GL++ R L + + ++
Sbjct: 2299 GTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTI 2358
Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
V A DGG P L ++ V+V D+NDN P+F + I E P V V A D
Sbjct: 2359 FVRAVDGGMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEA--RISEHAPHGHFVTCVKAYD 2416
Query: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 2699
D ++YS L +GN D + F+ID +G+I + + YSL L SD
Sbjct: 2417 ADSSDIDKLQYSIL--SGN-DHKHFVIDSATGIITLSNLHRHALKPFYSLNLSVSD---- 2469
Query: 2700 VPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEG 2759
+ + + V + + + P F++ +Y++ + E++P TLV V D D G
Sbjct: 2470 GVFRSSTQVHVTVIGGNLHSPAFLQN-----EYEV-ELAENAPLHTLVMEVK-TTDGDSG 2522
Query: 2760 PNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSP 2819
V Y I + F++ G + L LDRE A V+ +
Sbjct: 2523 IYGHVTYHIVNDFAKDRFYINERGQIFTLEKLDRETPAEKVISVRLMAK----------- 2571
Query: 2820 TLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNS 2879
D + V V+L D ND P+F +Y + + A G+ +++VLA DAD G+N+
Sbjct: 2572 --DAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNA 2629
Query: 2880 LVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAG 2939
+ Y+I A DSE V + + + G++ T + + +F + A D
Sbjct: 2630 DITYAIEA---------DSESVKENLEINKLSGVITTKESLIGLENEFFTFFVRAVDNGS 2680
Query: 2940 HNDTAIIGIYI 2950
+ +++ +Y+
Sbjct: 2681 PSKESVVLVYV 2691
Score = 753 bits (1943), Expect = 0.0
Identities = 783/2952 (26%), Positives = 1295/2952 (43%), Gaps = 282/2952 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGE------EASRFFAVEPDTGVVWLRQPLDR 95
+ E+T + +S+ ++ A D D G +GE + + FA+ P +GV+ L LD
Sbjct: 158 LPENTAIRTSIARVSATDAD-----IGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDY 212
Query: 96 ETKSEFTVEFSVSDH-------QGVIT-RKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
+ +E +D G+ + K+ + + N+ AP S P
Sbjct: 213 LETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLS---PSELDR 269
Query: 148 GTPIFIVNATDPDLGAGGSV----LYSFQPPSQFFAIDSARGI----VTVIRELDYETTQ 199
IV D D GA G + + + QF + S G V I +D+++
Sbjct: 270 DPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHP 329
Query: 200 -AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRII 258
Y LT+ A D+ S++ + + + F Y I E +PP T V ++
Sbjct: 330 FGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMV 389
Query: 259 TAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE 318
AI + Y S + F+L+Y +G++++ + R+ + F L V
Sbjct: 390 KAIPAYS----HLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAH---FELEV---- 438
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
T SD +T + V+ N N PEF + Y A E +G + + + VD DE
Sbjct: 439 -----TTSDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTV-MSLSAVDPDE 492
Query: 379 NLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR-YDFDLFANESV 437
+ + Y + N +H P ++ + + LDYE + R Y + A++
Sbjct: 493 G---ENGYVTYSIANLNH----VPFAIDHFTG-AVSTSENLDYELMPRVYTLRIRASDWG 544
Query: 438 PDHVGYAKV--KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEV 495
+ +V ITL N NDN P+F + ++ ++ VG + TV A D D +
Sbjct: 545 LPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQLVQY 604
Query: 496 SYFFSDDPDRFSLDKDTGLIMLIARLDYEL---IQRFTLTIIARDGGGEETTGRVRINVL 552
++ D FSL+ ++G++ L L L + +L I A DG T + I V
Sbjct: 605 QIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVA 664
Query: 553 -------------------------------------------DVNDNVPTFQKDAYVG- 568
VN ++P F+ G
Sbjct: 665 ASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGI 724
Query: 569 ALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLD 628
++EN+P + ++ + +TD D+ N ++ Y+ VS S F I + G++ + PLD
Sbjct: 725 QVKENQPVGSSVIFMNSTDLDTGFNGKLVYA-VSGGNEDSCFMIDMET--GMLKILSPLD 781
Query: 629 YEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGA 688
E + +TV D G P + + + V D NDNPP F + +YFV V E+ +
Sbjct: 782 RETTDKYTLNITV--YDLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHS 839
Query: 689 TVLFLNATDLDRSREYGQESIIYSLEGSTQ-FRINARSGEITTTSLLDRETKSEYILIVR 747
++ + ATD D + YS+ T F I++ +G + LDRE + E+ L +
Sbjct: 840 EIIQVEATDKDLG---PNGHVTYSIVTDTDTFSIDSVTGVVNIARPLDRELQHEHSLKIE 896
Query: 748 AVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDL 807
A D Q V ++L D+NDN PT+ Y + + E P + + + A DPDL
Sbjct: 897 ARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDL 956
Query: 808 GENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRP 866
G++G + YS+ + + ++ +G +R + E + + + V D G+
Sbjct: 957 GQSGQVRYSLLDHGEGNFDVDKLSGAVRIVQQL-------DFEKKQVYNLTVRAKDKGK- 1008
Query: 867 PLKATSSATVFVNLLDLNDN--DPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGL 924
P+ +S+ V V ++D+N+N P F + V E P G + V A D D +G
Sbjct: 1009 PVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGE 1068
Query: 925 VSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 984
+ Y + G F I +GV+ T+ LDRE + Y L V A+D G SS + I
Sbjct: 1069 IRYSIRDGSGVGVFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIE 1128
Query: 985 VLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFS 1044
V DVND P VY + E+ P++ VV + D D N +L Y IT GN G FS
Sbjct: 1129 VEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSSNDKLMYKITSGNPQGFFS 1188
Query: 1045 VGYRDAVVRTVV-GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFL 1103
+ + ++ T LDRE ++L + DNG K + A V V +LD NDN+P FL
Sbjct: 1189 IHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPK--STIARVIVKILDENDNKPQFL 1246
Query: 1104 QSSYEASVPE-DIPE------GHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSN 1156
Q Y+ +PE + P+ + + ATD DEG + Y I GN F I
Sbjct: 1247 QKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKT 1306
Query: 1157 GLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDE----APVFTQQQ 1212
G++ E + +L ++A D G + S +++E I+ P+ ++
Sbjct: 1307 GVVSSKRFSAAGEYD---ILSIKAV--DNGRPQKSSTTRLHIEWISKPKPSLEPISFEES 1361
Query: 1213 YSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGA--EGKFEIDESTGLIITVNY 1270
+ + E+ + + V+ G+ + ++G + F++D+ TG II
Sbjct: 1362 FFTFTVMESDPVAHMIGVISVE-----PPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKP 1416
Query: 1271 LDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGT 1330
LD E K++Y + V ATD V+I +++ D QFS + YE I E+ A T
Sbjct: 1417 LDAEQKSNYNLTVEATDGTTTI---LTQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPET 1473
Query: 1331 EIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV- 1389
EI+++ A D N++ Y + + F++D TG + +D E +TLTV
Sbjct: 1474 EILQISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVM 1533
Query: 1390 VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAG 1449
V D P + ++ + V D ND++P F +S + E VG V V A D D G
Sbjct: 1534 VRDQDVPVKRNFARIVVNVSDTNDHAPWFTASSYKG-RVYESAAVGSVVLQVTALDKDKG 1592
Query: 1450 SNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKK 1509
N +V++S+ SGNI +F I + +G + A+ LDR Y L V A+D+G+PP +
Sbjct: 1593 KNAEVLYSIESGNIGNSFMI---DPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSE 1649
Query: 1510 DHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITE 1569
+++ + ++ P S Y+V ++E V G+ V V A + S + Y I +
Sbjct: 1650 ITSVRIFVTIADNASPKFTSK-EYSVELSETVSIGSFVGMVTAHSQ-----SSVVYEIKD 1703
Query: 1570 GNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEND 1629
GN AF ++ SG I T+ A D E Y L+ ++ LS T V V + DEND
Sbjct: 1704 GNTGDAFDINPHSGTIITQKA-LDFETLPIYTLI--IQGTNMAGLSTNTTVLVHLQDEND 1760
Query: 1630 NAPMFQQPHYEVLLDEGPDTLNTSLIT-------IQALDLDEGPNGTVTYAIVAGNIVNT 1682
NAP+F Q Y L+ E ++N+ ++T I+A D D+ N + Y IV ++
Sbjct: 1761 NAPVFMQAEYTGLISESA-SINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTY 1819
Query: 1683 FRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVP 1742
F ID G I LDYE + + + P L + T V+V DIND P
Sbjct: 1820 FAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVT--VHVIDINDCPP 1877
Query: 1743 TFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLR 1802
F + + G +V T A D DS Q+ YSI +G+ +F + G L
Sbjct: 1878 VFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALT 1937
Query: 1803 VRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISE 1862
V+ +L Y LT+ A D L+S V I V + ++ + + E
Sbjct: 1938 VQNTTQLRSR----YELTVRASDGRFAGLTS---VKINVKESKESHLKFTQDVYSAVVKE 1990
Query: 1863 NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIV-TVNRPLDRERIPE 1921
NS + +A + A + N L ++I N +R F I+ T+G++ T P DRE+
Sbjct: 1991 NSTEAETLAVITA--IGNPINEPLFYHIL--NPDRRFKISRTSGVLSTTGTPFDREQQEA 2046
Query: 1922 YKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVL 1981
+ + + V + + +A + ++ + + D+NDN P+F Y A V ++ G +
Sbjct: 2047 FDVVVEVTEEHKPSAVA---HVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRY- 2102
Query: 1982 NGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
+ A+D D V Y L F I G ++++ +D + L + +
Sbjct: 2103 ---VTAVDRDSGRNGEVHYYLKEHHEH-FQI-GPLGEISLKKQFELD--TLNKEYL-VTV 2154
Query: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
+A+D G +A +++ I N P F + + E+ V+ V A + GL
Sbjct: 2155 VAKDGGNPAFSAEVIVPITVMNKAMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE-GL- 2212
Query: 2102 GELVYRIEAGAQ-DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV 2160
++ Y I G +F I+ TGVI V A +D E +Y+L++ ATD T V
Sbjct: 2213 -KVFYSITDGDPFSQFTINFNTGVINV-IAPLDFEAHPAYKLSIRATDSLT-GAHAEVFV 2269
Query: 2161 TILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPK--LEYHIVGIVAKD 2218
I++DDIND+ P F V++ E++ GT + + A D D P + Y + G +K
Sbjct: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSK- 2328
Query: 2219 DTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAK 2278
D F V+ +TG + + ++ E + + + +D +P S V
Sbjct: 2329 --------SHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRAVDGG--MPTLSSDV---I 2375
Query: 2279 LTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDL 2338
+TV+V D+NDN P F+ Y RI E A G + V A D D + Y++L
Sbjct: 2376 VTVDVTDLNDNPPLFEQ---QIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSG 2432
Query: 2339 VPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDN 2398
+ + DS+ G + + + + + + SD + V++ ++ N +
Sbjct: 2433 NDHKHFVI-DSATGIITLSNLHRHALKPFYSLNLSVSDG---VFRSSTQVHVTVIGGNLH 2488
Query: 2399 NPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGD--GESKFAINPTTGD 2456
+P F Q Y+ + E+ P+ T+++ V TD DSG + + Y + + + +F IN G
Sbjct: 2489 SPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFYIN-ERGQ 2547
Query: 2457 IYVLSSLDREKKDHYILTA--LAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQF 2514
I+ L LDRE +++ +AKD G VA V + + D ND PQF ++
Sbjct: 2548 IFTLEKLDRETPAEKVISVRLMAKDAGGKVA------FCTVNVILTDDNDNAPQFRATKY 2601
Query: 2515 STSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG---VEAFHVDMDSGLVTTQRPL 2571
++ + GTSV+ ++A+D DEG N ++TY++E E ++ SG++TT+ L
Sbjct: 2602 EVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESL 2661
Query: 2572 QSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLR 2629
E F+ V A D G P ++ V+++ P F P + E++P+
Sbjct: 2662 IGLENEFFTFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEP--FYTFTVSEDVPIG 2719
Query: 2630 SNVYEVYATDKDEGLNGAVRYSFLK---TAGNRDWEFFIIDPISGLIQTAQRLDRESQAV 2686
+ + + A +G V YS +K NRD E F+ID SG ++ + LD E+
Sbjct: 2720 TEIDLIRAEH-----SGTVLYSLVKGNTPESNRD-ESFVIDRQSGRLKLEKSLDHETTKW 2773
Query: 2687 YSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTL 2746
Y ++A + + ++D +DN P+F P Y+ V E+ P G+
Sbjct: 2774 YQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSP-----YEAFIV-ENLPGGSR 2827
Query: 2747 VGNVTGAVDADEGPNAIVYYFIAAGNEE---KNFHLQPD-GCLLVLRDLDREREAIFSFI 2802
V + A DAD G N V Y + ++F + + G + L++LD E+ +
Sbjct: 2828 VIQIR-ASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIK 2886
Query: 2803 VKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVG 2862
V AS + G L A V V + D+ND PPRFT Y V+ D G
Sbjct: 2887 VVASDH-------GEKIQLSSTA-----IVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQG 2934
Query: 2863 SELIQVLALDAD 2874
+ + DAD
Sbjct: 2935 GVIAILSTTDAD 2946
Score = 639 bits (1649), Expect = 0.0
Identities = 603/2160 (27%), Positives = 977/2160 (45%), Gaps = 165/2160 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ E VGS V Q+ A D D N +++ + F ++P G + + LDR +
Sbjct: 1571 VYESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQ 1630
Query: 99 SEFTVEFSVSDH----QGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
+E+ + +D IT V I V ++ +P F ++ YSV + E +G+ + +V
Sbjct: 1631 AEYDLMVKATDKGSPPMSEIT-SVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMV 1689
Query: 155 NATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDK 212
A SV+Y + + F I+ G + + LD+ET Y L + T+
Sbjct: 1690 TAHSQS-----SVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNM-- 1742
Query: 213 TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR-------IITAIDQDK 265
LST + + + D D P+F+ Y+ I E + + V +I A D DK
Sbjct: 1743 -AGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADK 1801
Query: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
+ Y IV + ++ FA+D +G + LD E H TV+ ++ R
Sbjct: 1802 DSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFH---FTVQVHDMGTPRLF 1858
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
++ T + VIDIND P F Y ++ G + + + D D + +
Sbjct: 1859 AEYAANVTVH--VIDINDCPPVFAKPLYEASLLLPTYKGVKV-ITVNATDADSSAFSQLI 1915
Query: 386 FEVYLVGNNSHHFIIS----PTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHV 441
+ + GN F + +VQ +R R YE R FA
Sbjct: 1916 YSI-TEGNIGEKFSMDYKTGALTVQNTTQLRSR------YELTVRASDGRFA-------- 1960
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD 501
G VKI + ++ F+Q +Y+ + EN T ++ + A N E ++
Sbjct: 1961 GLTSVKINVKESKESHLKFTQDVYSAVVKENSTEAETLAVITAIGNP---INEPLFYHIL 2017
Query: 502 DPDR-FSLDKDTGLIMLIAR-LDYELIQRFTLTIIARDGGGEETTGRVRINVL--DVNDN 557
+PDR F + + +G++ D E + F + + + V + V+ D NDN
Sbjct: 2018 NPDRRFKISRTSGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDN 2077
Query: 558 VPTFQKDAYVGALRENEPSVTQLVR-LRATDEDSPPNNQITYSIVSASAFGSYFDISLYE 616
P F Y ++ + V ++R + A D DS N ++ Y + +F I
Sbjct: 2078 APVFVNLPYYAVVKV-DTEVGHVIRYVTAVDRDSGRNGEVHYYL---KEHHEHFQIG--- 2130
Query: 617 GYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAY 676
G IS+ + + + ++ + +TV+A D GNP ++ V V I V N P F KP Y
Sbjct: 2131 PLGEISLKKQFELDTLNKEYL-VTVVAKDGGNPAFSAEVIVPITVM--NKAMPVFEKPFY 2187
Query: 677 FVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGS---TQFRINARSGEITTTSL 733
+ E+I + V+ + A + + + YS+ +QF IN +G I +
Sbjct: 2188 SAEIAESIQVHSPVVHVQANSPEGLK------VFYSITDGDPFSQFTINFNTGVINVIAP 2241
Query: 734 LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793
LD E Y L +RA D G + + V+I + DINDN P + Y + L E +
Sbjct: 2242 LDFEAHPAYKLSIRATDSLTGAHAEV---FVDIIVDDINDNPPVFAQQSYAVTLSEASVI 2298
Query: 794 DSDVTTVVAVDPDLGENGTLVYSI----QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHE 849
+ V V A D D N + Y + + + ++S+TG I LD E H
Sbjct: 2299 GTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISLLRT-LDYEQSRQHT 2357
Query: 850 AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSI 909
I V D G P L +S V V++ DLNDN P F+ + A + E P G +
Sbjct: 2358 ------IFVRAVDGGMPTL--SSDVIVTVDVTDLNDNPPLFEQQIYEARISEHAPHGHFV 2409
Query: 910 YQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE-YQLRVVAS 968
V A D D + Y + G F+I+S++G++ T + L R + Y L + S
Sbjct: 2410 TCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATGII-TLSNLHRHALKPFYSLNLSVS 2468
Query: 969 DAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNA 1028
D S++ + + V+ N +P F Y V ++E+ P V+ + TD D G+
Sbjct: 2469 DG---VFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYG 2525
Query: 1029 ELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATV 1088
++Y I +F + R + T+ LDRET A ++ + + GK TV
Sbjct: 2526 HVTYHIVNDFAKDRFYINERGQIF-TLEKLDRETPAEKVISVRLMAKDAGGK--VAFCTV 2582
Query: 1089 FVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHG- 1147
V + D NDN P F + YE ++ +G S++++ A+DADEG + Y I +
Sbjct: 2583 NVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITYAIEADSESV 2642
Query: 1148 -NNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEA- 1205
N I+ +G++ + E N V A ++ P + SV V+VYV+ + E
Sbjct: 2643 KENLEINKLSGVITTKESLIGLE-NEFFTFFVRAVDNG-SPSKESV-VLVYVKILPPEMQ 2699
Query: 1206 -PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG------AEGKFEI 1258
P F++ Y+ + E IGT + +++A G V Y ++ G + F I
Sbjct: 2700 LPKFSEPFYT-FTVSEDVPIGTEIDLIRAEH-----SGTVLYSLVKGNTPESNRDESFVI 2753
Query: 1259 DESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQ-GFCSVYITLLNELDEAVQFSNAS 1317
D +G + LD+ET Y ++ A V I + + D + F ++
Sbjct: 2754 DRQSGRLKLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSP 2813
Query: 1318 YEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVITVQG 1375
YEA I+ENL G+ +++++A D+ Q+ Y + S + F I+ TG IT
Sbjct: 2814 YEAFIVENLPGGSRVIQIRASDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLK 2873
Query: 1376 LVDREKGDFYTLTVVADDGGPKVD--STVKVYITVLDENDNSPRFDFTSDSAVSIPEDCP 1433
+D EK D Y + VVA D G K+ ST V +TV D ND+ PRF ++ ED P
Sbjct: 2874 ELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKG-TVSEDDP 2932
Query: 1434 VGQRVATVKAWDPDAGS-NGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDH 1492
G +A + D D+ N QV + + G+ G F + T + +V+V +PLDRE+ D+
Sbjct: 2933 QGGVIAILSTTDADSEEINRQVTYFITGGDPLGQFAVETIQNE-WKVYVKKPLDREKRDN 2991
Query: 1493 YILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRA 1552
Y+L + A+D GT K I++V +LD NDN PV E Y+ ++ E+V G ++Q+ A
Sbjct: 2992 YLLTITATD-GTFSSKA--IVEVKVLDANDNSPVCEKTL-YSDTIPEDVLPGKLIMQISA 3047
Query: 1553 TDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTP 1612
TD DI N+ ++Y + G+ F+++ +GE+ T P DRE Q+ YHL+ D G
Sbjct: 3048 TDADIRSNAEITYTLL-GSGAEKFKLNPDTGELKTS-TPLDREEQAVYHLLVRATDGGGR 3105
Query: 1613 TLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTY 1672
A+ + +T+ D NDNAP F Y + + E + T L +QA D D G N + Y
Sbjct: 3106 FCQAS--IVLTLEDVNDNAPEFSADPYAITVFENTEP-GTLLTRVQATDADAGLNRKILY 3162
Query: 1673 AIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLV 1732
+++ + F I+ G+I K LD E+ YTL + A DQ L RLT+T TV+V
Sbjct: 3163 SLI-DSADGQFSINELSGIIQLEKPLDRELQ-AVYTLSLKAVDQG--LPRRLTATGTVIV 3218
Query: 1733 NVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEF 1792
+V DINDN P F G + G V A RD N ++ YSI+ G+ G+F
Sbjct: 3219 SVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKF 3278
Query: 1793 VISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLL 1852
I G + + ++ LD E+ Y LT+ A D G P LS V + V DINDN PV
Sbjct: 3279 SIDSKTGAVFIIEN--LDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFS 3336
Query: 1853 NLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNR 1912
ISE++ + V V+A DAD N+ + ++I GN+ +F I+ G V V +
Sbjct: 3337 QDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTK 3396
Query: 1913 PLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENS 1972
LDRE I Y LT+ DN PR+ + + I +SD NDN P+F++ Y + EN
Sbjct: 3397 LLDRETISGYTLTVQASDNGSPPRV---NTTTVNIDVSDVNDNAPVFSRGNYSVIIQENK 3453
Query: 1973 PAGTPLTVLNGPILALDADQD----IYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIID 2028
P G +VL + D+ + + +VT G F++N GV+ S I
Sbjct: 3454 PVG--FSVLQLVVTDEDSSHNGPPFFFTIVT----GNDEKAFEVNPQ-GVLLTSSA--IK 3504
Query: 2029 REAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV 2088
R+ +L++ + L+S ++ I +++++ P P + + G +
Sbjct: 3505 RKEKDHYLLQVKVADNGKPQLSSLTYIDIRVIEESIYPPAILPLEIFITSSGEEYSGGVI 3564
Query: 2089 LQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATD 2148
++ ATD+D + L Y ++ + F + G + + + +D + Y L V TD
Sbjct: 3565 GKIHATDQD--VYDTLTYSLDPQMDNLFSVSSTGGKL-IAHKKLDIGQ---YLLNVSVTD 3618
Score = 473 bits (1218), Expect = e-132
Identities = 383/1288 (29%), Positives = 605/1288 (46%), Gaps = 86/1288 (6%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDN---DPLVFGVSGEEASRFFAVEPDTG 85
P F ++ ISE P G VT + A D D+ D L + + + F ++ TG
Sbjct: 2388 PLFEQQIYEAR--ISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDSATG 2445
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
++ L K +++ SVSD + +V++ V N ++P F Y V + EN
Sbjct: 2446 IITLSNLHRHALKPFYSLNLSVSDGVFRSSTQVHVTVIGGNLHSPAFLQNEYEVELAENA 2505
Query: 146 PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAID----SARGIVTVIRELDYETTQAY 201
P+ T + V TD D G G V Y FA D + RG + + +LD ET
Sbjct: 2506 PLHTLVMEVKTTDGDSGIYGHVTYHIVND---FAKDRFYINERGQIFTLEKLDRETPAEK 2562
Query: 202 QLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAI 261
++V +D ++ + +I+TD D P F Y NI + GT+V + A
Sbjct: 2563 VISVRLMAKDAGGKVA-FCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLAS 2621
Query: 262 DQDKGRPRGIGYTIV--SGNTNSIFALDYISGVLTLN-GLLDRENPLYSHGFILTVKGTE 318
D D+G I Y I S + ++ +SGV+T L+ EN ++ F+ V
Sbjct: 2622 DADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTF-FVRAV---- 2676
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDE 378
D+ +PS +V + + ++ P+F+ Y+ ++E +G + L + E
Sbjct: 2677 --DNGSPSKESVVLVY-VKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLI-----RAE 2728
Query: 379 NLGLNSMFEVY-LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV 437
+ G +Y LV N+ + V + R+++ LD+ET Y F + A +
Sbjct: 2729 HSGT----VLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILARCTQ 2784
Query: 438 PDH--VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEV 495
DH V V I + + NDN P+F Y + EN+ G+ V+ + A+D D+GT G+V
Sbjct: 2785 DDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTNGQV 2844
Query: 496 SYFFSDDP-----DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE---ETTGRV 547
Y + F+++ +TG I + LD+E + + ++A D G + +T V
Sbjct: 2845 MYSLDQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIV 2904
Query: 548 RINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPP-NNQITYSIVSASAF 606
+ V DVND+ P F + Y G + E++P + L TD DS N Q+TY I
Sbjct: 2905 DVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQVTYFITGGDPL 2964
Query: 607 GSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDEND 666
G F + + + V +PLD E+ N L LT+ A D +S V ++V D ND
Sbjct: 2965 GQ-FAVETIQNEWKVYVKKPLDREKRDNYL--LTITATDG---TFSSKAIVEVKVLDAND 3018
Query: 667 NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGS--TQFRINAR 724
N P K Y ++ E+++ G ++ ++ATD D I Y+L GS +F++N
Sbjct: 3019 NSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIR---SNAEITYTLLGSGAEKFKLNPD 3075
Query: 725 SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 784
+GE+ T++ LDRE ++ Y L+VRA DGG Q A++ +TL D+NDN P + PY
Sbjct: 3076 TGELKTSTPLDREEQAVYHLLVRATDGGGRFCQ----ASIVLTLEDVNDNAPEFSADPYA 3131
Query: 785 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPNKFYSLNSTTGKIRTTHAMLDRE 843
I + E T P + +T V A D D G N ++YS I + +S+N +G I+ E
Sbjct: 3132 ITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQFSINELSGIIQL-------E 3184
Query: 844 NPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGI 903
P E + + + + D G P + T++ TV V++LD+NDN P F+ + A V E I
Sbjct: 3185 KPLDRELQAVYTLSLKAVDQGLPR-RLTATGTVIVSVLDINDNPPVFEYREYGATVSEDI 3243
Query: 904 PAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQL 963
G + QV A D N ++Y + G F I+S +G V LD E EY L
Sbjct: 3244 LVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYL 3303
Query: 964 RVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDND 1023
V A+D GTP+ S +T+ ++V D+ND TP F Y +SED E V+ + D D
Sbjct: 3304 TVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDAD 3363
Query: 1024 VGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHT 1083
N+ + Y I GN F++ V+ LDRET + Y L ++A DNG
Sbjct: 3364 GPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNG--SPPRV 3421
Query: 1084 GTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFG-RVWYRIL 1142
T TV + V DVNDN P+F + +Y + E+ P G S+LQL TD D G ++ I+
Sbjct: 3422 NTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV 3481
Query: 1143 HGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVI---VYVE 1199
GN F ++ LL + R+ ++L V+ ++ P SS+ I V E
Sbjct: 3482 TGNDEKAFEVNPQGVLLTSS--AIKRKEKDHYLLQVKVADNG-KPQLSSLTYIDIRVIEE 3538
Query: 1200 DINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEID 1259
I A + + + G + G+ + + ATD+D D + Y + + F +
Sbjct: 3539 SIYPPAILPLEIFITSSGEEYSGGV---IGKIHATDQDVYD--TLTYSLDPQMDNLFSVS 3593
Query: 1260 ESTGLIITVNYLDYETKTSYMMNVSATD 1287
+ G +I LD Y++NVS TD
Sbjct: 3594 STGGKLIAHKKLDI---GQYLLNVSVTD 3618
Score = 388 bits (997), Expect = e-107
Identities = 455/1705 (26%), Positives = 745/1705 (43%), Gaps = 214/1705 (12%)
Query: 1311 VQFSNASYEAAILENLALGTEI---VRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA- 1366
+QF++ Y + EN A T + V++ Y ++ Y+ S ++ LFK +
Sbjct: 32 LQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKI---VSGDSENLFKAEEY 88
Query: 1367 ITGV-----ITVQG----LVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPR 1417
I G I +G +++RE D YTL V A + V++ KV + VLD ND P
Sbjct: 89 ILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEARTKVRVQVLDTNDLRPL 148
Query: 1418 FDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIG 1477
F TS S VS+PE+ + +A V A D D G+NG+ +S ++ + + G
Sbjct: 149 FSPTSYS-VSLPENTAIRTSIARVSATDADIGTNGEFYYSFKDRT-----DMFAIHPTSG 202
Query: 1478 EVFVARPLDREELDHYILQVVASDRGTPPRKKDHI-----LQVTILDINDNPPVIESPFG 1532
+ + LD E Y ++++A+DRG I L V I N+ PVI +
Sbjct: 203 VIVLTGRLDYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA--- 259
Query: 1533 YNVSVNENVGGGTAVVQVRATDRDIGIN-SVLSYYITEGNKDMAFRMDRI---SGEIATR 1588
+S +E + A V D D G N + S I G+ FR R S E +
Sbjct: 260 VTLSPSE-LDRDPAYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVK 318
Query: 1589 P-APPDRERQSF-YHLVATVEDEGT-PTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDE 1645
D + F Y+L +D+GT P S+ ++VT F++ Y + E
Sbjct: 319 AIGGIDWDSHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISE 378
Query: 1646 GPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHG 1705
NT ++ ++A+ + Y + F ++ + G+I+ + + +
Sbjct: 379 FAPP-NTPVVMVKAIP----AYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQ-QAA 432
Query: 1706 RYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD-YEGPFEVTEGQP-GPRV 1763
+ L VT +D+ ++T VLV V N N P F + Y+ F+ E P G V
Sbjct: 433 HFELEVTTSDR--------KASTKVLVKVLGANSNPPEFTQTAYKAAFD--ENVPIGTTV 482
Query: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETI-AFYNLTIC 1822
+ A D D G NG V YSI + + + F I G + ++ LD E + Y L I
Sbjct: 483 MSLSAVDPDEGENGYVTYSIANLNHV-PFAIDHFTGAVSTSEN--LDYELMPRVYTLRIR 539
Query: 1823 ARDRGMPPLSST-MLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSG 1881
A D G+P +L I + ++NDN P+ + TI + V + V A DAD
Sbjct: 540 ASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADE- 598
Query: 1882 CNARLTFNITAGNRERAFFINATTGIVTVNRPLD---RERIPEYKLTISVKDNP------ 1932
+ + I AGN F +N +G++++ R L ++ + L I+ D
Sbjct: 599 -LQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGENFATPL 657
Query: 1933 -----------------ENPRIARRDYDLLL-------------IFLSDENDN-HPLFTK 1961
E +A+ + LL IF + N H +
Sbjct: 658 YINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFR 717
Query: 1962 STYQA--EVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGA-QSGLFDINSSTGV 2018
ST +V EN P G+ + +N + D D + Y + G + F I+ TG+
Sbjct: 718 STLPTGIQVKENQPVGSSVIFMN----STDLDTGFNGKLVYAVSGGNEDSCFMIDMETGM 773
Query: 2019 VTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLL--ITILDDNDNRPTFSPATLTV 2076
+ + S +DRE L + + D+G+ A L + ++D NDN P F + V
Sbjct: 774 LKILSP--LDRETTDKYTLNITVY--DLGIPQKAAWRLLHVVVVDANDNPPEFLQESYFV 829
Query: 2077 HLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREE 2136
+ E+ ++QV ATD+D G NG + Y I D F I VTGV+ + +DRE
Sbjct: 830 EVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTDT-DTFSIDSVTGVVNIAR-PLDREL 887
Query: 2137 QESYRLTVVATD--RGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIA 2194
Q + L + A D R L T +V + ++D+ND+ P F+ P V V E GTVI
Sbjct: 888 QHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIM 947
Query: 2195 NITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATY 2254
+ A D DL + L+ + E F V+ +G+V + ++ E Y
Sbjct: 948 WLEAHDPDLGQSGQVRY----------SLLDHGEGNFDVDKLSGAVRIVQQLDFEKKQVY 997
Query: 2255 EVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMER--ILEGATPG 2312
+T+ D + S + V V+DVN+N P + ++E+ + E A G
Sbjct: 998 NLTVRAKDKGKPVSLSS----TCYVEVEVVDVNEN---LHPPVFSSFVEKGTVKEDAPVG 1050
Query: 2313 TTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTV 2372
+ ++ V+A D D +G + Y++ D G ++ + + G + + +D E TV
Sbjct: 1051 SLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEET-GVIETSDRLDRESTSHYWLTV 1109
Query: 2373 RASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSG 2432
A+D G P ++ I +Y+E+ D+NDN P +P Y + E+ P ++ + A D DS
Sbjct: 1110 FATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSS 1169
Query: 2433 NFALIEYSL--GDGESKFAINPTTGDIYVLS-SLDREKKDHYILTALAKDNPGDVASNRR 2489
+ + Y + G+ + F+I+P TG I S LDRE++D +IL DN S +
Sbjct: 1170 SNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHILEVTVTDN----GSPPK 1225
Query: 2490 ENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTS-------VITMMATDQDEGPNG 2542
+V++++LD ND +PQF + + + E E + ++ATD+DEGPN
Sbjct: 1226 STIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARREPLYHVIATDKDEGPNA 1285
Query: 2543 ELTYSLE-GPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEV 2601
E++YS+E G F ++ +G+V+++R + E L++ A D G P TT L +E
Sbjct: 1286 EISYSIEDGNEHGKFFIEPKTGVVSSKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIE- 1344
Query: 2602 IDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYS-------FLK 2654
++ P ++ I E + + V +D + G + F
Sbjct: 1345 ---------WISKPKPSLEPISFEESFFT--FTVMESDPVAHMIGVISVEPPGIPLWFDI 1393
Query: 2655 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALED 2714
T GN D F +D +G I A+ LD E ++ Y+L + A+D T QV ++
Sbjct: 1394 TGGNYD-SHFDVDKGTGTIIVAKPLDAEQKSNYNLTVEATD------GTTTILTQVFIKV 1446
Query: 2715 IDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGN-- 2772
ID N+ RP + +Y+++ +PE + T + ++ AVD DE N ++Y ++ +
Sbjct: 1447 IDTNDH---RPQFSTSKYEVV-IPEDTAPETEILQIS-AVDQDE-KNKLIYTLQSSRDPL 1500
Query: 2773 EEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQE 2831
K F L P G L LD E + V D+
Sbjct: 1501 SLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQ-------------DVPVKRNFAR 1547
Query: 2832 VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYF 2891
+ V + D ND P FT + Y V A VGS ++QV ALD D G N+ V YSI
Sbjct: 1548 IVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAEVLYSI------ 1601
Query: 2892 RALANDSEDVGQVFTMGSMDGILRT 2916
+S ++G F + + G ++T
Sbjct: 1602 -----ESGNIGNSFMIDPVLGSIKT 1621
Score = 297 bits (760), Expect = 1e-79
Identities = 318/1181 (26%), Positives = 523/1181 (44%), Gaps = 164/1181 (13%)
Query: 1853 NLPMNITISENSPVSSFVAHVLASDADSGCNA-RLTFNITAGNRERAF-----------F 1900
+L N+T+ ENS ++V H + A + + I +G+ E F F
Sbjct: 36 HLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDSENLFKAEEYILGDFCF 95
Query: 1901 INATT--GIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPL 1958
+ T G + L+RE Y T+ VK +N + R + + + D ND PL
Sbjct: 96 LRIRTKGGNTAI---LNREVKDHY--TLIVKALEKNTNVEARTK--VRVQVLDTNDLRPL 148
Query: 1959 FTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGV 2018
F+ ++Y + EN+ T + ++ A DAD Y ++ +F I+ ++GV
Sbjct: 149 FSPTSYSVSLPENTAIRTSIARVS----ATDADIGTNGEFYYSFKD-RTDMFAIHPTSGV 203
Query: 2019 VTVRSGVIIDREAFSPPILELLLLAEDIGL-------LNSTAHLLITILDDNDNRPTFSP 2071
+ + + + + E+ +LA D G+ ++S A L + I N+ P +
Sbjct: 204 IVLTGRL----DYLETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITA 259
Query: 2072 ATLTVHLLENCPPGFSVLQVTATDEDSGLNGELV-YRIEAG--AQDRFLIHLVTG----- 2123
TL+ L+ P +++ VT D D G NG++ I AG Q + G
Sbjct: 260 VTLSPSELDR-DPAYAI--VTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYK 316
Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVP-LSGTAIVTILIDDINDSRPEFLNPIQTVS 2182
V +G D Y LT+ A D+GT P S ++ + +F +
Sbjct: 317 VKAIGGIDWD-SHPFGYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAE 375
Query: 2183 VLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV 2242
+ E A P T + + AI Y + V K + F++N NTG + +
Sbjct: 376 ISEFAPPNTPVVMVKAIP-------AYSHLRYVFKSTPGKA------KFSLNYNTGLISI 422
Query: 2243 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYM 2302
P+ R+ A +E+ ++ D + + K+ V VL N N P+F T Y
Sbjct: 423 LEPVKRQQAAHFELEVTTSDRKA----------STKVLVKVLGANSNPPEFTQ---TAYK 469
Query: 2303 ERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDY 2362
E GTT+++++AVDPD+G NG VTY++ +L + D G V + +DY
Sbjct: 470 AAFDENVPIGTTVMSLSAVDPDEGENGYVTYSIANLNHVPFAI--DHFTGAVSTSENLDY 527
Query: 2363 EEVHWL-NFTVRASDNGSP-PRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTI 2420
E + + +RASD G P R E+ + + ++NDN P+F++ + + + D+ VG
Sbjct: 528 ELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLFEKINCEGTIPRDLGVGEQ 587
Query: 2421 ILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDR---EKKDHYILTALA 2477
I TV+A DAD + G+ F++NP +G + + SL K + L A
Sbjct: 588 ITTVSAIDADELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITA 647
Query: 2478 KDNPGDVA----------------------------------SNRRENSVQVVIQVLD-- 2501
D +N+ N +V D
Sbjct: 648 TDGENFATPLYINITVAASHKLVNLQCEETGVAKMLAEKLLQANKLHNQGEVEDIFFDSH 707
Query: 2502 -VNDCRPQF-SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA-FHV 2558
VN PQF S V EN+P G+SVI M +TD D G NG+L Y++ G ++ F +
Sbjct: 708 SVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLDTGFNGKLVYAVSGGNEDSCFMI 767
Query: 2559 DMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPN 2616
DM++G++ PL ++ +K++L + D G P +L V V+D NDN P F++
Sbjct: 768 DMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVVDANDNPPEFLQ--E 825
Query: 2617 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTA 2676
+ + E+ + S + +V ATDKD G NG V YS + D + F ID ++G++ A
Sbjct: 826 SYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVT-----DTDTFSIDSVTGVVNIA 880
Query: 2677 QRLDRESQAVYSLILVASDLGQPVP--YETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL 2734
+ LDRE Q +SL + A D + P + T+ ++V+LED++DN P F+ P Y++
Sbjct: 881 RPLDRELQHEHSLKIEARDQAREEPQLFSTVV-VKVSLEDVNDNPPTFI-----PPNYRV 934
Query: 2735 LTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDR 2793
V E P GT++ + A D D G + V Y + + E NF + G + +++ LD
Sbjct: 935 -KVREDLPEGTVIMWLE-AHDPDLGQSGQVRYSLL-DHGEGNFDVDKLSGAVRIVQQLDF 991
Query: 2794 EREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTA 2853
E++ +++ V+A +G +L + EV VV + N PP F+
Sbjct: 992 EKKQVYNLTVRAKD-------KGKPVSLSSTCYV---EVEVVDVNENLHPPVFSSFVEKG 1041
Query: 2854 GVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGI 2913
V DA VGS ++ V A D D + + YSI D VG VF +G G+
Sbjct: 1042 TVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI----------RDGSGVG-VFKIGEETGV 1090
Query: 2914 LRTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRDD 2954
+ T D S ++ + + A D ++ I IYI +D
Sbjct: 1091 IETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVED 1131
Score = 49.3 bits (116), Expect = 6e-05
Identities = 49/182 (26%), Positives = 77/182 (42%), Gaps = 25/182 (13%)
Query: 2714 DIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNE 2773
D D ++ L P + + +TV E+S T VG+ P V Y I +G+
Sbjct: 20 DSDGSQRLEQTPLQFTHLEYNVTVQENSAAKTYVGHPVKMGVYITHPAWEVRYKIVSGDS 79
Query: 2774 EKNF----HLQPDGCLLVLRD-------LDREREAIFSFIVKASSNRSWTPPRGPSPTLD 2822
E F ++ D C L +R L+RE + ++ IVKA + R
Sbjct: 80 ENLFKAEEYILGDFCFLRIRTKGGNTAILNREVKDHYTLIVKALEKNTNVEAR------- 132
Query: 2823 LVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882
+VRV + D ND P F+ Y+ + + + + + +V A DADIG N +
Sbjct: 133 -------TKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIRTSIARVSATDADIGTNGEFY 185
Query: 2883 YS 2884
YS
Sbjct: 186 YS 187
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 895 bits (2314), Expect = 0.0
Identities = 850/2981 (28%), Positives = 1376/2981 (46%), Gaps = 242/2981 (8%)
Query: 25 VNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVE 81
+NR + + F + + + ED PVG+++ ++ A D D N ++F +S F ++
Sbjct: 718 INRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNTDSCFNID 777
Query: 82 PDTGVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQPYS 138
+TG + + P+DRE + + ++ D Q R + I V D NDN+P F YS
Sbjct: 778 METGQLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVFIQDSYS 837
Query: 139 VRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETT 198
V I E++ +GT I V A D DLG+ G V YS +Q FAI+S+ GIV V +LD E+
Sbjct: 838 VNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESK 897
Query: 199 QAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRI 257
Y L + A D+ + + L ++ L + + DV D P FI YS + E P GT +
Sbjct: 898 ANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAW 957
Query: 258 ITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
+ D D G + Y++V+ + N F +D SG + L+ LD E + + LTV+
Sbjct: 958 LETHDPDLGLGGQVRYSLVN-DYNGRFEIDKASGAIRLSKELDYEKQQF---YNLTVRA- 1012
Query: 318 ELNDDRTPSDATVTTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQVVD 375
D P + + + V+D+N+N P F ++ E +++G ++ +QV
Sbjct: 1013 --KDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSV---LQVTA 1067
Query: 376 KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE 435
+DE+ G + + Y + + S + S+ ++ + I A LD ET+ Y ++A +
Sbjct: 1068 RDEDSGRDGEIQ-YSIRDGSG---LGRFSIDDESGV-ITAADILDRETMGSYWLTVYATD 1122
Query: 436 -SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGE 494
V +V I + + NDN P+ S+P+Y + EN SV+ + A D D+ + +
Sbjct: 1123 RGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEK 1182
Query: 495 VSY-FFSDDPDR-FSLDKDTGLIMLIAR-LDYELIQRFTLTIIARDGG--GEETTGRVRI 549
++Y S +P F+++ TGLI +R LD E L + DGG +++T V +
Sbjct: 1183 LTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVV 1242
Query: 550 NVLDVNDNVPTFQKDAYVGAL--RENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFG 607
VLD NDN P F + Y L R+ + + R A D D PN +I+YSIV + G
Sbjct: 1243 QVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDG 1302
Query: 608 SYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDE--- 664
+F + G++S + + + LT+ A+D G P +ST + IE +
Sbjct: 1303 KFF---IDPKTGMVSSRK----QFTAGSYDILTIKAVDNGRPQKSSTARLHIEWIKKPPP 1355
Query: 665 NDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINAR 724
+ P TF +P Y +V+E+ V ++ + + I + F
Sbjct: 1356 SPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFD----IVGGNFDSAFDAEKG 1411
Query: 725 SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYY 784
G I LD E +S Y + V DG + V I +LD NDN P + Y
Sbjct: 1412 VGTIVIAKPLDAEQRSIYNMSVEVTDG-----TNVAVTQVFIKVLDNNDNGPEFSQPNYD 1466
Query: 785 INLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQP-----PNKFYSLNSTTGKIRTTHAM 839
+ + E PD+++ + A D D E L Y++ + + ++ +TG + T
Sbjct: 1467 VTISEDVLPDTEILQIEATDRD--EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAE-R 1523
Query: 840 LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEV 899
LD E D H +M V D P + + A V VN+ D ND+ P F N + A V
Sbjct: 1524 LDHEAQDKHILNIM------VRDQEFPYRR--NLARVIVNVEDANDHSPYFTNPLYEASV 1575
Query: 900 LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA 959
E G ++ QV A+D D+G N + Y + G F I G++ E D +
Sbjct: 1576 FESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMG 1635
Query: 960 EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019
++ L + +D G+P S+T+ + I V ++ P F Y V+E+V V+ ++
Sbjct: 1636 QFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISA 1695
Query: 1020 TDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVG 1079
+ L Y + G+++G F++ V+ T LD E T++Y LI++A + +
Sbjct: 1696 IS-----QSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGM- 1749
Query: 1080 KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEG-------HSILQLKATDADEG 1132
ATV + ++D NDN P+FL S Y S+ E P +S L ++ATDAD
Sbjct: 1750 ---ASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSN 1806
Query: 1133 EFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSS---HVLIVEAYNHDLGPMR 1189
+ Y+I+ F + S G + R LD E + HV + ++ + L
Sbjct: 1807 RNALLVYQIVESTAKKFFTVDSSTGAI-RTIANLDHETIAHFHFHVHVRDSGSPQL-TAE 1864
Query: 1190 SSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL 1249
S V V + V D+ND PVFTQ + + L T +G V+ V ATD DS + Y ++
Sbjct: 1865 SPVEVNIEVTDVNDNPPVFTQAVFETILLLPTY-VGVEVLKVSATDPDSEVPPELTYSLM 1923
Query: 1250 SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLL--NEL 1307
G+ F ID ++G++ N + +K YM+ V +D + + + +T++ +
Sbjct: 1924 EGSLDHFLIDSNSGVLTIKN--NNLSKDHYMLIVKVSD-----GKFYSTSMVTIMVKEAM 1976
Query: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAI 1367
D + F+ + Y +I EN T++ V A + LN+ Y+ FKI +
Sbjct: 1977 DSGLHFTQSFYSTSISENNTNITKVAIVNAVG-NRLNEPL----KYSILNPGNKFKIKST 2031
Query: 1368 TGVITVQGL-VDREKGDFYTLTVVADDGGPKVD----STVKVYITVLDENDNSPRFDFTS 1422
+GVI G+ DRE+ + Y L V + ++D + V V + + D NDNSP F
Sbjct: 2032 SGVIQTTGVPFDREEQELYELVV---EASRELDHLRVARVVVRVNIEDINDNSPVFVGLP 2088
Query: 1423 DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVA 1482
A ++ D G + V A D D G NG+V + L G FEI N + G V +
Sbjct: 2089 YYA-AVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDD--YGHFEI---NPNSGNVILK 2142
Query: 1483 RPLDREELD-HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENV 1541
+ + + Y + ++A D G P L +TI +N PV + PF Y SVNE++
Sbjct: 2143 EAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITI--VNKAMPVFDKPF-YTASVNEDI 2199
Query: 1542 GGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYH 1601
T ++ + AT + + Y I +G+ F +D +G + +P D E S Y
Sbjct: 2200 RMNTPILSINATSPE---GQGIIYIIIDGDPFKQFNIDFDTGVLKV-VSPLDYEVTSAYK 2255
Query: 1602 LVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALD 1661
L D T + T V + + D NDN P+F QP Y L E + T ++ + ++D
Sbjct: 2256 LTIRASDALTGARAEVT-VDLLVNDVNDNPPIFDQPTYNTTLSEA-SLIGTPVLQVVSID 2313
Query: 1662 LDEGPNGTVTYAIVAG--NIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQ-CP 1718
D N V Y IV N + F ID G+I A+ LD+E+ TL V + D P
Sbjct: 2314 ADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQ-HCTLKVRSIDSGFP 2372
Query: 1719 ILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQ 1778
LS S V + ++D+NDN P F + + G V A D DS +
Sbjct: 2373 SLS----SEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDR 2428
Query: 1779 VEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVG 1838
+EYSI+ G+ F++ GV+ + + E + Y+L + D G+ +ST V
Sbjct: 2429 LEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPL--YSLNVSVSD-GL--FTSTAQVH 2483
Query: 1839 IRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERA 1898
IRVL N P + EN + V HV A+D D G ++++ I +
Sbjct: 2484 IRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDR 2543
Query: 1899 FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPL 1958
F I++ ++T R LDRE E ++I V+ R + + + + DENDN P
Sbjct: 2544 FLIDSNGQVITTER-LDRENPLEGDVSIFVRALDGG---GRTTFCTVRVIVVDENDNAPQ 2599
Query: 1959 FTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS----GLFDINS 2014
F Y+A V + G +T + A+D D + +TY L S L +I+
Sbjct: 2600 FMTVEYRASVRADVGRGHLVT----QVQAIDPDDGANSRITYSLYSEASVSVADLLEIDP 2655
Query: 2015 STGVVTVRSGVIIDREAFSPPILELLLLAEDIGL--LNSTAHLLITILDDNDNRPTFSPA 2072
G + + +L + A D G+ +S + I +L P+F+ +
Sbjct: 2656 DNGWMVTKGNF----NQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQS 2711
Query: 2073 TLTVHLLENCPPGFSV--LQVTATDE--DSGLNGELVYRIEAGAQDRFLIHLVTGVIRVG 2128
+ + E+ G +V L++ + S +NGE R E F+I TG I++
Sbjct: 2712 QYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGE---RPENNKGGIFVIEQETGTIKL- 2767
Query: 2129 NATIDREEQESYRLTVVAT-DRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESA 2187
+ +DRE ++ V AT V + T V I + D+ND++P F ++E
Sbjct: 2768 DKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIMEGM 2827
Query: 2188 EPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSP 2245
GT + + AID D N ++ Y + +D +AF ++ NTG +
Sbjct: 2828 PVGTKLTQVRAIDMDWGANGQVTYSL-------HSDSQPEKVMEAFNIDSNTGWISTLKD 2880
Query: 2246 MNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERI 2305
++ E T+ T SV+ ASDL E A ++V V D+NDN P F Y +
Sbjct: 2881 LDHETDPTF--TFSVV--ASDLGEAFSLSSTALVSVRVTDINDNAPVFAQ---EVYRGNV 2933
Query: 2306 LEGATPGTTLIAVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLE-DSSAGKVIANRTVDYE 2363
E PG + ++ D D +N V+Y + P G L S KV R +D E
Sbjct: 2934 KESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDRE 2993
Query: 2364 E--VHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTII 2421
E +++LN T A+D +A V + + D+NDN+P+ DQ +Y + ED+P II
Sbjct: 2994 EQDIYFLNIT--ATDGLFVTQAM---VEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKII 3048
Query: 2422 LTVTATDADSGNFALIEYSL-GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDN 2480
L V+A DAD G+ I YSL G G S+F ++P +G++ L+ LDRE+ Y L A A D
Sbjct: 3049 LKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSLMAKATDG 3108
Query: 2481 PGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2540
G ++++ ++++ DVND P FS ++T VYEN + + A D D G
Sbjct: 3109 GGRFC----QSNIHLILE--DVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGI 3162
Query: 2541 NGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGE-PPLWGTTML 2597
N ++ YSL F +D SG++ ++PL + ++++V ATD L T +
Sbjct: 3163 NRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSSLTTV 3222
Query: 2598 LVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAG 2657
+ V+D+NDN PVF R ++ + E+ + V V+AT KD G N + Y L +G
Sbjct: 3223 TITVLDINDNPPVFER--RDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITY--LIRSG 3278
Query: 2658 NRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDD 2717
N + F I+P +G I ++ LD E + L++ A D G P + + + L D++D
Sbjct: 3279 NEQGK-FKINPKTGGISVSEVLDYELCKRFYLVVEAKDGGTPA-LSAVATVNINLTDVND 3336
Query: 2718 NEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNF 2777
N PPK S + E + G V + A D D PN +++ I G+ + F
Sbjct: 3337 N------PPKFSQDVYSAVISEDALVGDSV-ILLIAEDVDSQPNGQIHFSIVNGDRDNEF 3389
Query: 2778 HLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVL 2836
+ P G + V + LDRER + +S +V+A S P + T V + +
Sbjct: 3390 TVDPVLGLVKVKKKLDRERVSGYSLLVQAVD--SGIPAMSSTAT-----------VNIDI 3436
Query: 2837 EDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF-YSILAIHYFRALA 2895
D+ND P FT A YTA + + VG+ ++Q++ D D +N F +SIL+
Sbjct: 3437 SDVNDNSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILS-------G 3489
Query: 2896 NDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARD 2936
N+ E+ F + GILR+ +F +V+ + A+D
Sbjct: 3490 NEEEE----FVL-DPHGILRSAVVFQHTESLEYVLCVQAKD 3525
Score = 879 bits (2270), Expect = 0.0
Identities = 847/2948 (28%), Positives = 1321/2948 (44%), Gaps = 254/2948 (8%)
Query: 41 LISEDTPVGSSVTQLLAQDMDNDPLVFG--VSGEEASRFFAVEPDTGVVWLRQPLDRE-- 96
+IS D PVG +T + A D+D LV +SG E FF + PD+GV+ L++ L
Sbjct: 586 VISYDFPVGGHITAVSAIDIDELELVKYKIISGNELG-FFYLNPDSGVLQLKKSLTNSGI 644
Query: 97 TKSEFTVEFSVSDHQGVI-----------------------TR----------------- 116
F + + +D + + TR
Sbjct: 645 KNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANG 704
Query: 117 KVNIQVG-----DVNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYS 170
K+N++ G +N P F P V + E+ PVG I + A D D G G VL++
Sbjct: 705 KLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLFT 764
Query: 171 FQP--PSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITD 228
F ID G + V+ +D E T Y L + D + S+ L I + D
Sbjct: 765 ISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQK-SSWRLLTINVED 823
Query: 229 VQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDY 288
D P+FI YS NI E S GT + + A D+D G + Y++++ FA++
Sbjct: 824 ANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDTQQ--FAINS 881
Query: 289 ISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 348
+G++ + LDRE+ + L ++ + + + V T + + D+ND +P F
Sbjct: 882 STGIVYVADQLDRES---KANYSLKIEARDKAESGQQLFSVV--TLKVFLDDVNDCSPAF 936
Query: 349 NSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGK 408
S YSV + E VG + +++ D D LGL LV + + F I K
Sbjct: 937 IPSSYSVKVLEDLPVGTVI-AWLETHDPD--LGLGGQVRYSLVNDYNGRFEID------K 987
Query: 409 ADIRIRVAIPLDYETVDRYDFDLFANES----VPDHVGYAKVKITLINENDNRPIFSQPL 464
A IR++ LDYE Y+ + A + V + +V++ +NEN + P F
Sbjct: 988 ASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFA 1047
Query: 465 YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP--DRFSLDKDTGLIMLIARLD 522
S+ EN +GTSVL V A D D+G GE+ Y D RFS+D ++G+I LD
Sbjct: 1048 VVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILD 1107
Query: 523 YELIQRFTLTIIARDGGGEE--TTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQL 580
E + + LT+ A D G +T V I V DVNDN P + Y + EN P +
Sbjct: 1108 RETMGSYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSV 1167
Query: 581 VRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 640
++++A D DS N ++TY I S + ++F I++ G + + SR LD EQ + + +T
Sbjct: 1168 IQIQAEDPDSSSNEKLTYRITSGNP-QNFFAINIKTGL-ITTTSRKLDREQQAEHFLEVT 1225
Query: 641 VMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDR 700
V D G P ST+ V ++V DENDN P F + Y + + E A DR
Sbjct: 1226 V--TDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDR 1283
Query: 701 SREYGQESIIYSLEGST--QFRINARSGEITTTSLLDRETKSEY-ILIVRAVDGGVGHNQ 757
E ++G+ +F I+ ++G +++ + T Y IL ++AVD G Q
Sbjct: 1284 DEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRK---QFTAGSYDILTIKAVDN--GRPQ 1338
Query: 758 KTGIATVNITLLDINDNH--PTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
K+ A ++I + P D P+Y V + +++ VV+V P N L +
Sbjct: 1339 KSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQP---ANTPLWF 1395
Query: 816 SIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSAT 875
I N + ++ G A P E + + V VTD +
Sbjct: 1396 DIVGGNFDSAFDAEKGVGTIVIA-----KPLDAEQRSIYNMSVEVTDGTN-----VAVTQ 1445
Query: 876 VFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPR 935
VF+ +LD NDN P F + + E + I Q+ A D DE +SY + +
Sbjct: 1446 VFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQIEATDRDE--KHKLSYTVHSSIDS 1503
Query: 936 MD---FLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDET 992
+ F I+ S+GV+ T LD E ++ L ++ D P + + + + ++V D ND +
Sbjct: 1504 ISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHS 1563
Query: 993 PTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVV 1052
P F +Y SV E V+ + D D G NAEL Y I GN F + ++
Sbjct: 1564 PYFTNPLYEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGII 1623
Query: 1053 RTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVP 1112
D T ++L ++ D G T + VT+ D ++ P F+ Y+A V
Sbjct: 1624 TICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSD--NSHPKFIHKDYQAEVN 1681
Query: 1113 EDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNS 1172
E++ G S++ + A + Y + G+ F I+ +G++ + LD ER S
Sbjct: 1682 ENVDIGTSVILISAISQ-----STLIYEVKDGDINGIFTINPYSGVITT-QKALDYERTS 1735
Query: 1173 SHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGT------ 1226
S+ LI++A N + M S+ V + + D ND APVF QYS L E A I +
Sbjct: 1736 SYQLIIQATN--MAGMASNATVNIQIVDENDNAPVFLFSQYSG-SLSEAAPINSIVRSLD 1792
Query: 1227 -SVIVVQATDRDSGDGGLVNYRIL-SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVS 1284
S +V++ATD DS L+ Y+I+ S A+ F +D STG I T+ LD+ET + +V
Sbjct: 1793 NSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHVH 1852
Query: 1285 ATDQAPP--FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
D P + V I + + D F+ A +E +L +G E+++V A D+
Sbjct: 1853 VRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDS 1912
Query: 1343 --LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDS 1400
++TY + F ID+ +GV+T++ + D Y L V DG K S
Sbjct: 1913 EVPPELTYSLMEGSLDH----FLIDSNSGVLTIKN--NNLSKDHYMLIVKVSDG--KFYS 1964
Query: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
T V I V + D+ F S + SI E+ +VA V A G+ +
Sbjct: 1965 TSMVTIMVKEAMDSGLHFT-QSFYSTSISENNTNITKVAIVNA----VGNRLNEPLKYSI 2019
Query: 1461 GNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDI 1520
N F+I +T+ I V P DREE + Y L V AS R +++V I DI
Sbjct: 2020 LNPGNKFKIKSTSGVIQTTGV--PFDREEQELYELVVEASRELDHLRVARVVVRVNIEDI 2077
Query: 1521 NDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDR 1580
NDN PV Y +V + GT + QV A D+D G N ++Y + + F ++
Sbjct: 2078 NDNSPVFVG-LPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGH--FEINP 2134
Query: 1581 ISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE 1640
SG + + A Y + +D G P+LS + + +TIV N P+F +P Y
Sbjct: 2135 NSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPITIV--NKAMPVFDKPFYT 2192
Query: 1641 VLLDEGPDTLNTSLITIQALDLDEGPNGT-VTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699
++E +NT +++I A P G + Y I+ G+ F ID GV+ LD
Sbjct: 2193 ASVNE-DIRMNTPILSINA----TSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLD 2247
Query: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP 1759
YE++ Y L + A+D + R T +L VND+NDN P F +
Sbjct: 2248 YEVT-SAYKLTIRASD--ALTGARAEVTVDLL--VNDVNDNPPIFDQPTYNTTLSEASLI 2302
Query: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDG--DPLGEFVISPVEGVLRVRKDVELDRETIAFY 1817
G V ++ D DS N V Y I+ + F I G++ + LD E +
Sbjct: 2303 GTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTAR--MLDHELVQHC 2360
Query: 1818 NLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASD 1877
L + + D G P LSS +LV I + D+NDN PV L +SE +P FV V ASD
Sbjct: 2361 TLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASD 2420
Query: 1878 ADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRI 1937
ADS RL ++I +GN +F +++ +G++T++ + P Y L +SV D
Sbjct: 2421 ADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTSTA 2480
Query: 1938 ARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV 1997
+ I + N P F++STY AEV EN AGT + + A D D Y
Sbjct: 2481 Q------VHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVI----HVRATDGDPGTYGQ 2530
Query: 1998 VTYQLLG-AQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLL 2056
++Y ++ F I+S+ V+T +DRE + + + A D G + +
Sbjct: 2531 ISYAIINDFAKDRFLIDSNGQVITTER---LDRENPLEGDVSIFVRALDGGGRTTFCTVR 2587
Query: 2057 ITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQ--- 2113
+ ++D+NDN P F + + G V QV A D D G N + Y + + A
Sbjct: 2588 VIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSV 2647
Query: 2114 -DRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAI-VTILIDDINDSR 2171
D I G + V ++ + V A D G +P+ + I V I +
Sbjct: 2648 ADLLEIDPDNGWM-VTKGNFNQLKNTVLSFFVKAVD-GGIPVKHSLIPVYIHVLPPETFL 2705
Query: 2172 PEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAF 2231
P F + ++ E G+ + + + + + + V + +R N+ F
Sbjct: 2706 PSFTQSQYSFTIAEDTAIGSTVDTLRILP---SQNVWFSTV------NGERPENNKGGIF 2756
Query: 2232 AVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP-NAKLTVNVLDVNDNT 2290
+ TG++ + ++RE + + A+ +P V + + + VLD+NDN
Sbjct: 2757 VIEQETGTIKLDKRLDRETSPAFHFKV-----AATIPLDKVDIVFTVDVDIKVLDLNDNK 2811
Query: 2291 PQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE--- 2347
P F+ + Y I+EG GT L V A+D D G NG VTY+L P V
Sbjct: 2812 PVFE---TSSYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNI 2868
Query: 2348 DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP-PRAAEIPVYLEIVDINDNNPIFDQPS 2406
DS+ G + + +D+E F+V ASD G ++ V + + DINDN P+F Q
Sbjct: 2869 DSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEV 2928
Query: 2407 YQEAVFEDVPVGTIILTVTATDADSGNF-ALIEYSL--GDGESKFAINPTTGD--IYVLS 2461
Y+ V E P G ++ ++ D D+ + + Y + G+ +FA+ + +YV
Sbjct: 2929 YRGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKR 2988
Query: 2462 SLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYEN 2521
LDRE++D Y L A D V + V DVND P + ++ + E+
Sbjct: 2989 PLDREEQDIYFLNITATD-------GLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPED 3041
Query: 2522 EPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
P+ ++ + A D D G NG + YSL G G F +D +SG + T L + +SL
Sbjct: 3042 IPSNKIILKVSAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLALLDRERIPVYSL 3101
Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
ATDGG L++E DVNDN PVF T ++ E ++ + V A D
Sbjct: 3102 MAKATDGGGRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVY--ENTATKALLTRVQAVD 3157
Query: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQP 2699
D G+N V YS +AG F ID SG+I Q LDRE Q+ Y++ + A+D
Sbjct: 3158 PDIGINRKVVYSLADSAGG----VFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPG 3213
Query: 2700 VPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEG 2759
++ + + + DI+DN P+F R + L+TVPE + GT V V A D G
Sbjct: 3214 QSLSSLTTVTITVLDINDNPPVFER------RDYLVTVPEDTSPGTQVLAVF-ATSKDIG 3266
Query: 2760 PNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPS 2818
NA + Y I +GNE+ F + P G + V LD E F +V+A G +
Sbjct: 3267 TNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKD--------GGT 3318
Query: 2819 PTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNN 2878
P L VA V + L D+ND PP+F++ Y+A ++ DA VG +I ++A D D N
Sbjct: 3319 PALSAVA-----TVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPN 3373
Query: 2879 SLVFYSIL 2886
+ +SI+
Sbjct: 3374 GQIHFSIV 3381
Score = 861 bits (2224), Expect = 0.0
Identities = 828/2983 (27%), Positives = 1344/2983 (45%), Gaps = 282/2983 (9%)
Query: 93 LDRETKSEFT--VEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTP 150
L+RE + + V+ SV KVNIQV D+ND P F YSV I E+TP+ T
Sbjct: 117 LNREIQDNYLLIVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTS 176
Query: 151 IFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQ 210
+ V ATD D+G+ G Y F+ F++ G++++ L+Y+ Y L + A D+
Sbjct: 177 VAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDR 236
Query: 211 DK----TRPLSTLANLAIIITDVQDMDP---IFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
+S+ A L + I + + P + ++P+S E P T ++T D
Sbjct: 237 GMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHVPFS---LEKEP---TYAVVTVDDL 290
Query: 264 DKGRPRGI-GYTIVSGNTNSIFALDYISGVLTLNGLLDREN---PLYSHGFILTVKGTEL 319
D G I +IV+G+ F L L + +R+ + +G+ LT++ +
Sbjct: 291 DDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDK 350
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAP-EFNSSEYSVAITELAQVGFA---LPLFIQVVD 375
+ S N D P F Y V+I+E + G + L + +D
Sbjct: 351 GSPQKCSALKAVYIGN----PTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID 406
Query: 376 KDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE 435
+ L G ++ +F I+P S I A PL+ + Y ++ E
Sbjct: 407 VEYKLS---------PGEDAVYFKINPRSG------LIVTARPLNTVKKEVYKLEVTNKE 451
Query: 436 SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEV 495
A+V I++ + ND+ P F QPLY+ + E+V VGTSVLTV A+D D G G +
Sbjct: 452 GDLK----AQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYI 507
Query: 496 SYFFSD-DPDRFSLDKDTGLIMLIARLDYELI-QRFTLTIIARDGGG---EETTGRVRIN 550
+Y + + F +++ TG+I LD+E + + + A D G E+ V I
Sbjct: 508 TYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIR 567
Query: 551 VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
+ +VNDN P F+K A G + + P + + A D D + Y I+S + G ++
Sbjct: 568 IGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDE--LELVKYKIISGNELGFFY 625
Query: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN--PPLNSTVPVT---------- 658
L GV+ + + L I NG L + A D N P++ + V
Sbjct: 626 ---LNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFS 682
Query: 659 ------------------------------IEVFDENDNPPTFSKP-AYFVSVVENIMAG 687
++ + N P F K V+V E++ G
Sbjct: 683 CRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVG 742
Query: 688 ATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILI 745
A +L + A D D + + + +G+T F I+ +G++ +DRE Y+L
Sbjct: 743 ANILKIKAYDADSG--FNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLN 800
Query: 746 VRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805
+ D +G+ QK+ + I + D NDN P + Y +N++E + +++ V A D
Sbjct: 801 ITIYD--LGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDK 858
Query: 806 DLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGR 865
DLG NG + YS+ + +++NS+TG + LDRE+ + + + D
Sbjct: 859 DLGSNGEVTYSVLTDTQQFAINSSTGIVYVAD-QLDRESKANY------SLKIEARDKAE 911
Query: 866 PPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLV 925
+ S T+ V L D+ND P F + +VLE +P G I + D D GL G V
Sbjct: 912 SGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQV 971
Query: 926 SYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTK-SSTSTLTIH 984
Y + V F I+ +SG + + ELD E+ Y L V A D G P SS S + +
Sbjct: 972 RYSL-VNDYNGRFEIDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVE 1030
Query: 985 VLDVNDETPT-FFPAVYNV-SVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGK 1042
V+DVN+ T +FP V SV E+ V+ + D D G + E+ Y I G+ G+
Sbjct: 1031 VVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGR 1090
Query: 1043 FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF 1102
FS+ V+ LDRET +Y L + A D G V T V++ V DVNDN P+
Sbjct: 1091 FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPL--YSTIEVYIEVEDVNDNAPLT 1148
Query: 1103 LQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRG 1162
+ Y V E+ P+ S++Q++A D D ++ YRI GN N F I++ GL+
Sbjct: 1149 SEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTT 1208
Query: 1163 PRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYS-RLGLRET 1221
R LDRE+ + H L V + P +S++ V+V V D ND P F ++ Y +L R+
Sbjct: 1209 SRKLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDR 1268
Query: 1222 AGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSY- 1279
G + A DRD G ++Y I+ G +GKF ID TG++ + T SY
Sbjct: 1269 KKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYD 1325
Query: 1280 MMNVSATDQAPPFNQGFCSVYITLLNELDEA---VQFSNASYEAAILENLALGTEIVRVQ 1336
++ + A D P ++I + + + + F Y ++E+ + TEIV V
Sbjct: 1326 ILTIKAVDNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV-TEIVGVV 1384
Query: 1337 AYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGP 1396
+ N T + + F + G I + +D E+ Y ++V DG
Sbjct: 1385 SVQPAN----TPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTDGTN 1440
Query: 1397 KVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVF 1456
+ +V+I VLD NDN P F + V+I ED + ++A D D ++ +
Sbjct: 1441 V--AVTQVFIKVLDNNDNGPEFS-QPNYDVTISEDVLPDTEILQIEATDRD--EKHKLSY 1495
Query: 1457 SLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVT 1516
++ S + + + S G ++ A LD E D +IL ++ D+ P R+ + V
Sbjct: 1496 TVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVN 1555
Query: 1517 ILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAF 1576
+ D ND+ P +P Y SV E+ G+AV+QV A D+D G N+ L Y I GN F
Sbjct: 1556 VEDANDHSPYFTNPL-YEASVFESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMF 1614
Query: 1577 RMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQ 1636
+++ + G I T PD + L V D+G+P +SAT V +++ +++ P F
Sbjct: 1615 KIEPVLG-IITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIH 1673
Query: 1637 PHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAK 1696
Y+ ++E D + TS+I I A+ T+ Y + G+I F I+ + GVIT K
Sbjct: 1674 KDYQAEVNENVD-IGTSVILISAIS-----QSTLIYEVKDGDINGIFTINPYSGVITTQK 1727
Query: 1697 ELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFP-RDYEGPFEVT 1755
LDYE + Y LI+ AT+ + S TV + + D NDN P F Y G ++
Sbjct: 1728 ALDYERT-SSYQLIIQATNMA-----GMASNATVNIQIVDENDNAPVFLFSQYSG--SLS 1779
Query: 1756 EGQPGPRVWTFL--------AHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDV 1807
E P + L A D DS N + Y I++ F + G +R
Sbjct: 1780 EAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGA--IRTIA 1837
Query: 1808 ELDRETIAFYNLTICARDRGMPPLS--STMLVGIRVLDINDNDPVLLNLPMNITISENSP 1865
LD ETIA ++ + RD G P L+ S + V I V D+NDN PV + +
Sbjct: 1838 NLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTY 1897
Query: 1866 VSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTV-NRPLDRERIPEYKL 1924
V V V A+D DS LT+++ G+ + F I++ +G++T+ N L ++ Y L
Sbjct: 1898 VGVEVLKVSATDPDSEVPPELTYSLMEGSLDH-FLIDSNSGVLTIKNNNLSKD---HYML 1953
Query: 1925 TISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGP 1984
+ V D ++ I + + D+ FT+S Y + EN+ T + ++N
Sbjct: 1954 IVKVSDG------KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNA- 2006
Query: 1985 ILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLA- 2043
+ + Y +L F I S++GV+ +GV DRE + EL++ A
Sbjct: 2007 -----VGNRLNEPLKYSILN-PGNKFKIKSTSGVIQT-TGVPFDRE--EQELYELVVEAS 2057
Query: 2044 -EDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNG 2102
E L + + + I D NDN P F + + PG + QVTA D+D G NG
Sbjct: 2058 RELDHLRVARVVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNG 2117
Query: 2103 ELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTI 2162
E+ Y ++ F I+ +G + + A Y +T++A D G LS + + I
Sbjct: 2118 EVTYVLQ-DDYGHFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDGGKPSLSTSVELPI 2176
Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDR 2222
I +N + P F P T SV E T I +I A + I+ I+ D +
Sbjct: 2177 TI--VNKAMPVFDKPFYTASVNEDIRMNTPILSINATSPE-----GQGIIYIIIDGDPFK 2229
Query: 2223 LVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVN 2282
F ++ +TG + V SP++ E+ + Y++T+ D +++ A++TV+
Sbjct: 2230 -------QFNIDFDTGVLKVVSPLDYEVTSAYKLTIRASD--------ALTGARAEVTVD 2274
Query: 2283 VL--DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLD--L 2338
+L DVNDN P F Y + E + GT ++ V ++D D N +V Y ++
Sbjct: 2275 LLVNDVNDNPPIFDQ---PTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTY 2331
Query: 2339 VPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDN 2398
Y + DSS+G ++ R +D+E V VR+ D+G P ++E+ V++ I D+NDN
Sbjct: 2332 NSTDYFHI-DSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSLSSEVLVHIYISDVNDN 2390
Query: 2399 NPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGD 2456
P+F+Q Y+ V E P G + V A+DADS +F +EYS+ G+ + F ++ +G
Sbjct: 2391 PPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGV 2450
Query: 2457 IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFST 2516
I + + + + Y L V+ ++ QV I+VL N P FS+ +
Sbjct: 2451 ITLSNHRKQRMEPLYSLNV-------SVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVA 2503
Query: 2517 SVYENEPAGTSVITMMATDQDEGPNGELTYSLEGP-GVEAFHVDMDSGLVTTQR-----P 2570
V EN AGT VI + ATD D G G+++Y++ + F +D + ++TT+R P
Sbjct: 2504 EVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLIDSNGQVITTERLDRENP 2563
Query: 2571 LQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRS 2630
L+ S+ V A DGG + T ++ V+D NDN P F+ +R ++
Sbjct: 2564 LEG--DVSIFVRALDGGGRTTFCTVRVI--VVDENDNAPQFMTVEYRA--SVRADVGRGH 2617
Query: 2631 NVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLI 2690
V +V A D D+G N + YS A + IDP +G + T ++ V S
Sbjct: 2618 LVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWMVTKGNFNQLKNTVLSFF 2677
Query: 2691 LVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNV 2750
+ A D G PV + ++ P+ + + + P F + QY T+ E + G+ V +
Sbjct: 2678 VKAVDGGIPVKH-SLIPVYIHVLPPETFLPSFTQ-----SQYS-FTIAEDTAIGSTVDTL 2730
Query: 2751 TGAVDADEGPNAIVYYFIAAGNEEKN-----FHL-QPDGCLLVLRDLDREREAIFSFIVK 2804
P+ V++ G +N F + Q G + + + LDRE F F V
Sbjct: 2731 RIL------PSQNVWFSTVNGERPENNKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVA 2784
Query: 2805 ASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSE 2864
A+ P +D+V + +V + + D+ND P F + Y + VG++
Sbjct: 2785 ATI---------PLDKVDIVFTV---DVDIKVLDLNDNKPVFETSSYDTIIMEGMPVGTK 2832
Query: 2865 LIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYS 2924
L QV A+D D G N V YS+ + + E V + F + S G + T +
Sbjct: 2833 LTQVRAIDMDWGANGQVTYSLHS-------DSQPEKVMEAFNIDSNTGWISTLKDLDHET 2885
Query: 2925 PGYFVVDIVARDLA---GHNDTAIIGIYILRDDQRVKIVINEI 2964
F +VA DL + TA++ + + + + E+
Sbjct: 2886 DPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEV 2928
Score = 761 bits (1965), Expect = 0.0
Identities = 799/2968 (26%), Positives = 1294/2968 (43%), Gaps = 294/2968 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRF------FAVEPDTGVVWLRQPLDR 95
I+E TP+ +SV Q+ A D D G +GE F F+V P +GV+ L L+
Sbjct: 167 IAESTPLRTSVAQVTATDAD-----IGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNY 221
Query: 96 ETKSEFTVEFSVSD-------HQGVI-TRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
+ K+ + +E D + GV T K+ + + +N++APT H +P +
Sbjct: 222 DEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIH---VVTHVPFSLEK 278
Query: 148 GTPIFIVNATDPDLGAGGSV----LYSFQPPSQFFAIDSARGI----VTVIRELDYET-T 198
+V D D GA G + + + P QFF + + + +++D+E+
Sbjct: 279 EPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFP 338
Query: 199 QAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPI-FINLPYSTNIYEHSPPGTTVRI 257
Y LT+ A D+ + S L I +D PI F Y +I E SPPG V I
Sbjct: 339 YGYNLTLQAKDKGSPQKCSAL-KAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAI 397
Query: 258 ITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
+ + P + Y + G F ++ SG++ L+ TVK
Sbjct: 398 VKLSPE----PIDVEYKLSPGEDAVYFKINPRSGLIVTARPLN------------TVKKE 441
Query: 318 ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
+ T + + I + D ND+ PEF Y + E VG ++ L + DKD
Sbjct: 442 VYKLEVTNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSV-LTVSASDKD 500
Query: 378 ENLGLNSMFEVYLVGNNSHHFIISP-TSVQGKADIRIRVAIPLDYETVDR-YDFDLFANE 435
+ G N + N F+I+ T V I LD+E+ Y F + A++
Sbjct: 501 K--GENGYITYSIASLNLLPFVINQFTGV-------ISTTEELDFESSPEIYRFIVRASD 551
Query: 436 --SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFG 493
S H V I + N NDN P+F + + + VG + V A D D
Sbjct: 552 WGSPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELELV 611
Query: 494 EVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQR--FTLTIIARDGGGEETTGRVRINV 551
+ ++ F L+ D+G++ L L I+ F L I A DG + I+V
Sbjct: 612 KYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPMSINISV 671
Query: 552 L--------------------------------------------DVNDNVPTFQKDAYV 567
L +N P F K
Sbjct: 672 LHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPS 731
Query: 568 G-ALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRP 626
A++E+ P +++++A D DS N ++ ++I + S F+I + G + V P
Sbjct: 732 DVAVKEDLPVGANILKIKAYDADSGFNGKVLFTISDGNT-DSCFNIDMETGQ--LKVLMP 788
Query: 627 LDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA 686
+D E L+ +T+ D GNP +S +TI V D NDN P F + +Y V+++E+
Sbjct: 789 MDREHTDLYLLNITIY--DLGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSGI 846
Query: 687 GATVLFLNATDLDRSREYGQESIIYS-LEGSTQFRINARSGEITTTSLLDRETKSEYILI 745
G ++ + A D D + YS L + QF IN+ +G + LDRE+K+ Y L
Sbjct: 847 GTEIIQVEARDKDLG---SNGEVTYSVLTDTQQFAINSSTGIVYVADQLDRESKANYSLK 903
Query: 746 VRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805
+ A D Q + T+ + L D+ND P + + Y + ++E P + + + DP
Sbjct: 904 IEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDP 963
Query: 806 DLGENGTLVYS-IQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCG 864
DLG G + YS + N + ++ +G IR + + +E + + V D G
Sbjct: 964 DLGLGGQVRYSLVNDYNGRFEIDKASGAIRLSKEL-------DYEKQQFYNLTVRAKDKG 1016
Query: 865 RPPLKATSSATVFVNLLDLNDN--DPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLN 922
RP + +S + V V ++D+N+N P F + V V E G S+ QV A D D G +
Sbjct: 1017 RP-VSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDSGRD 1075
Query: 923 GLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLT 982
G + Y + G F I+ SGV+ LDRE + Y L V A+D G ST +
Sbjct: 1076 GEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVY 1135
Query: 983 IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGK 1042
I V DVND P +Y V E+ P++ V+ + D D N +L+Y IT GN
Sbjct: 1136 IEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNF 1195
Query: 1043 FSVGYRDAVVRTVV-GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPI 1101
F++ + ++ T LDRE A + L + D GP K+ T V V VLD NDN+P
Sbjct: 1196 FAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGPSPKQ--STIWVVVQVLDENDNKPQ 1253
Query: 1102 FLQSSYEASVPE--DIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLL 1159
F + Y+ +PE G I + A D DEG + Y I+ GN F I G++
Sbjct: 1254 FPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTGMV 1313
Query: 1160 MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDIN----DEAPVFTQQQYSR 1215
+ S +L ++A D G + S +++E I P+ + +
Sbjct: 1314 SSRKQ---FTAGSYDILTIKAV--DNGRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYN 1368
Query: 1216 LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYE 1274
+ E+ + V VV ++ + + I+ G + F+ ++ G I+ LD E
Sbjct: 1369 FTVMESDRVTEIVGVVSVQPANTP----LWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAE 1424
Query: 1275 TKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVR 1334
++ Y M+V TD N V+I +L+ D +FS +Y+ I E++ TEI++
Sbjct: 1425 QRSIYNMSVEVTDGT---NVAVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQ 1481
Query: 1335 VQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV-VADD 1393
++A D ++++Y ++ + + F+ID TGV+ +D E D + L + V D
Sbjct: 1482 IEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQ 1541
Query: 1394 GGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453
P + +V + V D ND+SP F A S+ E +G V V A D D G N +
Sbjct: 1542 EFPYRRNLARVIVNVEDANDHSPYFTNPLYEA-SVFESAALGSAVLQVTALDKDKGENAE 1600
Query: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
+++++ +GN F+I +G + + + D + ++L + +D+G+PP I+
Sbjct: 1601 LIYTIEAGNTGNMFKI---EPVLGIITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIV 1657
Query: 1514 QVTI-LDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNK 1572
++++ + N +P I Y VNENV GT+V+ + A + S L Y + +G+
Sbjct: 1658 RISVTMSDNSHPKFIHK--DYQAEVNENVDIGTSVILISAISQ-----STLIYEVKDGDI 1710
Query: 1573 DMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAP 1632
+ F ++ SG I T+ A D ER S Y L+ ++ +++ V + IVDENDNAP
Sbjct: 1711 NGIFTINPYSGVITTQKA-LDYERTSSYQLI--IQATNMAGMASNATVNIQIVDENDNAP 1767
Query: 1633 MFQQPHYEVLLDEGPD------TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRID 1686
+F Y L E +L+ S + I+A D D N + Y IV F +D
Sbjct: 1768 VFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVD 1827
Query: 1687 RHMGVITAAKELDYE-ISHGRYTLIVTATDQCPILSHRLTSTTTVLVN--VNDINDNVPT 1743
G I LD+E I+H + + V + S +LT+ + V VN V D+NDN P
Sbjct: 1828 SSTGAIRTIANLDHETIAHFHFHVHVRDSG-----SPQLTAESPVEVNIEVTDVNDNPPV 1882
Query: 1744 FPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRV 1803
F + + G V A D DS ++ YS+M+G L F+I GVL +
Sbjct: 1883 FTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPELTYSLMEGS-LDHFLIDSNSGVLTI 1941
Query: 1804 RKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISEN 1863
K+ L ++ Y L + D ST +V I V + D+ + +ISEN
Sbjct: 1942 -KNNNLSKD---HYMLIVKVSD---GKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISEN 1994
Query: 1864 SPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIV-TVNRPLDRERIPEY 1922
+ + VA V A + N L ++I N F I +T+G++ T P DRE Y
Sbjct: 1995 NTNITKVAIVNA--VGNRLNEPLKYSIL--NPGNKFKIKSTSGVIQTTGVPFDREEQELY 2050
Query: 1923 KLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
+L + ++ R+AR ++ + + D NDN P+F Y A V ++ GT L
Sbjct: 2051 ELVVEASRELDHLRVAR---VVVRVNIEDINDNSPVFVGLPYYAAVQVDAEPGT----LI 2103
Query: 1983 GPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILEL--- 2039
+ A+D D+ VTY +L G F+IN + SG +I +EAF+ + +
Sbjct: 2104 YQVTAIDKDKGPNGEVTY-VLQDDYGHFEINPN-------SGNVILKEAFNSDLSNIEYG 2155
Query: 2040 -LLLAEDIG--LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2096
+LA+D G L+++ L ITI+ N P F T + E+ +L + AT
Sbjct: 2156 VTILAKDGGKPSLSTSVELPITIV--NKAMPVFDKPFYTASVNEDIRMNTPILSINATSP 2213
Query: 2097 DSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSG 2156
+ G + I+ +F I TGV++V + +D E +Y+LT+ A+D T
Sbjct: 2214 EG--QGIIYIIIDGDPFKQFNIDFDTGVLKV-VSPLDYEVTSAYKLTIRASDALT-GARA 2269
Query: 2157 TAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGI 2214
V +L++D+ND+ P F P ++ E++ GT + + +ID D N + Y IV
Sbjct: 2270 EVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENNKMVHYQIV-- 2327
Query: 2215 VAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSV 2274
DT N D F ++ ++G ++ ++ ELV TL V S P S V
Sbjct: 2328 ---QDT----YNSTDYFHIDSSSGLILTARMLDHELV--QHCTLKVRSIDSGFPSLSSEV 2378
Query: 2275 PNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYT 2334
+ + + DVNDN P F Y + E A G + V A D D + Y+
Sbjct: 2379 ---LVHIYISDVNDNPPVFNQL---IYESYVSELAPRGHFVTCVQASDADSSDFDRLEYS 2432
Query: 2335 LLDLVPPGYVQLEDSSAGKVIAN-RTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
+L ++ S ++N R E ++ LN +V +G A+ V++ ++
Sbjct: 2433 ILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSV---SDGLFTSTAQ--VHIRVL 2487
Query: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGD--GESKFAIN 2451
N +P F Q +Y V E+V GT ++ V ATD D G + I Y++ + + +F I+
Sbjct: 2488 GANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISYAIINDFAKDRFLID 2547
Query: 2452 PTTGDIYVLSSLDREK--KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF 2509
+ G + LDRE + + A D G R V + V+D ND PQF
Sbjct: 2548 -SNGQVITTERLDRENPLEGDVSIFVRALDGGG------RTTFCTVRVIVVDENDNAPQF 2600
Query: 2510 SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPG----VEAFHVDMDSGLV 2565
++ SV + G V + A D D+G N +TYSL + +D D+G +
Sbjct: 2601 MTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADLLEIDPDNGWM 2660
Query: 2566 TTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIR 2623
T+ + S V A DGG P + + V+ P F + I
Sbjct: 2661 VTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQSQYS--FTIA 2718
Query: 2624 EEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRES 2683
E+ + S V + V + N F+I+ +G I+ +RLDRE+
Sbjct: 2719 EDTAIGSTVDTLRILPSQNVWFSTVNG---ERPENNKGGIFVIEQETGTIKLDKRLDRET 2775
Query: 2684 QAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPR 2743
+ + A+ V + + + D++DN+P+F + Y + + E P
Sbjct: 2776 SPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVF-----ETSSYDTI-IMEGMPV 2829
Query: 2744 GTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKN----FHLQPD-GCLLVLRDLDREREAI 2798
GT + V A+D D G N V Y + + ++ + F++ + G + L+DLD E +
Sbjct: 2830 GTKLTQVR-AIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWISTLKDLDHETDPT 2888
Query: 2799 FSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATD 2858
F+F V AS G + +L A L VRV DIND P F + Y V
Sbjct: 2889 FTFSVVASD-------LGEAFSLSSTA---LVSVRVT--DINDNAPVFAQEVYRGNVKES 2936
Query: 2859 AKVGSELIQVLALDADIGN-NSLVFYSI 2885
G + + D D + N V Y I
Sbjct: 2937 DPPGEVVAVLSTWDRDTSDVNRQVSYHI 2964
Score = 696 bits (1795), Expect = 0.0
Identities = 619/2187 (28%), Positives = 994/2187 (45%), Gaps = 154/2187 (7%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
P+FTN ++ + E +GS+V Q+ A D D N L++ + F +EP G
Sbjct: 1564 PYFTNPLYEASVF--ESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLG 1621
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142
++ + + D T +F + V+D T V I V +++ P F ++ Y +
Sbjct: 1622 IITICKEPDMTTMGQFVLSIKVTDQGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVN 1681
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP--SQFFAIDSARGIVTVIRELDYETTQA 200
EN +GT + +++A +++Y + + F I+ G++T + LDYE T +
Sbjct: 1682 ENVDIGTSVILISAISQS-----TLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSS 1736
Query: 201 YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR---- 256
YQL + AT+ +++ A + I I D D P+F+ YS ++ E +P + VR
Sbjct: 1737 YQLIIQATNM---AGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDN 1793
Query: 257 ---IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILT 313
+I A D D R + Y IV F +D +G + LD E + H +
Sbjct: 1794 SPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFHV-- 1851
Query: 314 VKGTELNDDRTPS-DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQ 372
+ D +P A NI V D+NDN P F + + + VG + L +
Sbjct: 1852 ----HVRDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEV-LKVS 1906
Query: 373 VVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLF 432
D D + + L+ + HF+I S + + + + + L
Sbjct: 1907 ATDPDSEVPPELTYS--LMEGSLDHFLIDSNSG----------VLTIKNNNLSKDHYMLI 1954
Query: 433 ANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTF 492
S + V I + D+ F+Q Y+ S+ EN T T V V A N
Sbjct: 1955 VKVSDGKFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRLNE- 2013
Query: 493 GEVSYFFSDDPDRFSLDKDTGLIMLIA-RLDYELIQRFTLTIIARDGGGEETTGRV--RI 549
+ Y + ++F + +G+I D E + + L + A RV R+
Sbjct: 2014 -PLKYSILNPGNKFKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARVVVRV 2072
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY 609
N+ D+NDN P F Y A++ + T + ++ A D+D PN ++TY V +G +
Sbjct: 2073 NIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPNGEVTY--VLQDDYG-H 2129
Query: 610 FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
F+I+ G ++ + D I G+ T++A D G P L+++V + I + N P
Sbjct: 2130 FEINPNSGNVILKEAFNSDLSNIEYGV---TILAKDGGKPSLSTSVELPITIV--NKAMP 2184
Query: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST--QFRINARSGE 727
F KP Y SV E+I +L +NAT + GQ I ++G QF I+ +G
Sbjct: 2185 VFDKPFYTASVNEDIRMNTPILSINATSPE-----GQGIIYIIIDGDPFKQFNIDFDTGV 2239
Query: 728 ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINL 787
+ S LD E S Y L +RA D G + TV++ + D+NDN P + Y L
Sbjct: 2240 LKVVSPLDYEVTSAYKLTIRASDALTGARAEV---TVDLLVNDVNDNPPIFDQPTYNTTL 2296
Query: 788 VEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN----KFYSLNSTTGKIRTTHAMLDRE 843
E + + V VV++D D N + Y I ++ ++S++G I T MLD
Sbjct: 2297 SEASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTAR-MLD-- 2353
Query: 844 NPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGI 903
HE + V D G P L +S V + + D+NDN P F L + + V E
Sbjct: 2354 ----HELVQHCTLKVRSIDSGFPSL--SSEVLVHIYISDVNDNPPVFNQLIYESYVSELA 2407
Query: 904 PAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQL 963
P G + V A D D + Y + G R FL++S SGV+ + + Y L
Sbjct: 2408 PRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSL 2467
Query: 964 RVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDND 1023
V SD +ST+ + I VL N +P F + Y V E+V +V+ + TD D
Sbjct: 2468 NVSVSDG---LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGD 2524
Query: 1024 VGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAA--YMLILEAIDNGPVGKR 1081
G ++SY I +F + V+ T LDRE + + A+D G
Sbjct: 2525 PGTYGQISYAIINDFAKDRFLIDSNGQVI-TTERLDRENPLEGDVSIFVRALDGGG---- 2579
Query: 1082 HTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI 1141
T TV V V+D NDN P F+ Y ASV D+ GH + Q++A D D+G R+ Y +
Sbjct: 2580 RTTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSL 2639
Query: 1142 LHG---NHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYV 1198
+ + I NG ++ ++ +N+ V+A + + S + V ++V
Sbjct: 2640 YSEASVSVADLLEIDPDNGWMVTKGN-FNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHV 2698
Query: 1199 EDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN-YRILSGAEGKFE 1257
P FTQ QYS + E IG++V ++ + VN R + G F
Sbjct: 2699 LPPETFLPSFTQSQYS-FTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGGIFV 2757
Query: 1258 IDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFC-SVYITLLNELDEAVQFSNA 1316
I++ TG I LD ET ++ V+AT + F V I +L+ D F +
Sbjct: 2758 IEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETS 2817
Query: 1317 SYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQ-AKALFKIDAITGVITV 1373
SY+ I+E + +GT++ +V+A +D Q+TY ++ + + F ID+ TG I+
Sbjct: 2818 SYDTIIMEGMPVGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNIDSNTGWIST 2877
Query: 1374 QGLVDREKGDFYTLTVVADDGGP--KVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
+D E +T +VVA D G + ST V + V D NDN+P F ++ E
Sbjct: 2878 LKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVYRG-NVKES 2936
Query: 1432 CPVGQRVATVKAWDPDAGS-NGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREEL 1490
P G+ VA + WD D N QV + + GN G F + S +V+V RPLDREE
Sbjct: 2937 DPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQ-SEWKVYVKRPLDREEQ 2995
Query: 1491 DHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQV 1550
D Y L + A+D + +++V++ D+NDN PV + Y + E++ +++V
Sbjct: 2996 DIYFLNITATDGLFVTQA---MVEVSVSDVNDNSPVCDQ-VAYTALLPEDIPSNKIILKV 3051
Query: 1551 RATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEG 1610
A D DIG N + Y + G+ + F +D SGE+ T A DRER Y L+A D G
Sbjct: 3052 SAKDADIGSNGYIRYSLY-GSGNSEFFLDPESGELKTL-ALLDRERIPVYSLMAKATDGG 3109
Query: 1611 TPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLIT-IQALDLDEGPNGT 1669
+ H+ + D NDN P+F HY + E +T +L+T +QA+D D G N
Sbjct: 3110 GRFCQSNIHLILE--DVNDNPPVFSSDHYNTCVYE--NTATKALLTRVQAVDPDIGINRK 3165
Query: 1670 VTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTT 1729
V Y++ A + F ID G+I + LD E Y + V ATDQ P L+S TT
Sbjct: 3166 VVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE-QQSSYNISVRATDQSP--GQSLSSLTT 3221
Query: 1730 VLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPL 1789
V + V DINDN P F R + PG +V A +D G N ++ Y I G+
Sbjct: 3222 VTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQ 3281
Query: 1790 GEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDP 1849
G+F I+P G + V + LD E + L + A+D G P LS+ V I + D+NDN P
Sbjct: 3282 GKFKINPKTGGISVSE--VLDYELCKRFYLVVEAKDGGTPALSAVATVNINLTDVNDNPP 3339
Query: 1850 VLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVT 1909
+ ISE++ V V ++A D DS N ++ F+I G+R+ F ++ G+V
Sbjct: 3340 KFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVK 3399
Query: 1910 VNRPLDRERIPEYKLTISVKDN--PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAE 1967
V + LDRER+ Y L + D+ P A + D +SD NDN P+FT + Y A
Sbjct: 3400 VKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNID-----ISDVNDNSPVFTPANYTAV 3454
Query: 1968 VMENSPAGTPLTVLNGPILALDADQDIY---AVVTYQLLGAQSGLFDINSSTGVVTVRSG 2024
+ EN P GT + L + D+D + ++ +L + G+ +RS
Sbjct: 3455 IQENKPVGTSILQL------VVTDRDSFHNGPPFSFSILSGNEEEEFVLDPHGI--LRSA 3506
Query: 2025 VIIDREAFSPPILELLLLAEDIGLLNSTAH--LLITILDDNDNRPTFSPATLTVHLLENC 2082
V+ + L + A+D G +H + + +++++ ++PT P + + +E+
Sbjct: 3507 VVFQHTESLEYV--LCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDD 3564
Query: 2083 PPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTG-VIRVGNATIDREEQESYR 2141
PG + ++ ATD+D + L + +++ + F ++ G +I +G + Y
Sbjct: 3565 FPGGVIGKIHATDQD--MYDVLTFALKSEQKSLFKVNSHDGKIIALGGL-----DSGKYV 3617
Query: 2142 LTVVATD-RGTVPLSGTAIVTILIDDI 2167
L V +D R VP+ V L+ ++
Sbjct: 3618 LNVSVSDGRFQVPIDVVVHVEQLVHEM 3644
Score = 689 bits (1778), Expect = 0.0
Identities = 653/2289 (28%), Positives = 1026/2289 (44%), Gaps = 165/2289 (7%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDND-PLVFGVSGEEAS---RFFAVEPDT 84
P F+ +D + ISED + + Q+ A D D L + V S R F ++P T
Sbjct: 1458 PEFSQPNYD--VTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPST 1515
Query: 85 GVVWLRQPLDRETKSEFTVEFSVSDHQGVITR---KVNIQVGDVNDNAPTFHNQPYSVRI 141
GV++ + LD E + + + V D + R +V + V D ND++P F N Y +
Sbjct: 1516 GVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASV 1575
Query: 142 PENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQ 199
E+ +G+ + V A D D G ++Y+ + + F I+ GI+T+ +E D T
Sbjct: 1576 FESAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMG 1635
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
+ L++ TDQ P+S A + I +T + P FI+ Y + E+ GT+V +I+
Sbjct: 1636 QFVLSIKVTDQGSP-PMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILIS 1694
Query: 260 AIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTEL 319
AI Q + Y + G+ N IF ++ SGV+T LD E + + L ++ T +
Sbjct: 1695 AISQST-----LIYEVKDGDINGIFTINPYSGVITTQKALDYER---TSSYQLIIQATNM 1746
Query: 320 NDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL------PLFIQV 373
S+ATV NI ++D NDNAP F S+YS +++E A + + PL I+
Sbjct: 1747 AG--MASNATV----NIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVIRA 1800
Query: 374 VDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA 433
D D N N++ +V + + F +S IR LD+ET+ + F +
Sbjct: 1801 TDADSNR--NALLVYQIVESTAKKFFTVDSSTGA-----IRTIANLDHETIAHFHFHVHV 1853
Query: 434 NESVPDHV---GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAG 490
+S + +V I + + NDN P+F+Q ++ L VG VL V ATD D+
Sbjct: 1854 RDSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVLKVSATDPDSE 1913
Query: 491 TFGEVSYFFSDDP-DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRI 549
E++Y + D F +D ++G++ + + L + + I+ G +T V I
Sbjct: 1914 VPPELTYSLMEGSLDHFLIDSNSGVLTI---KNNNLSKDHYMLIVKVSDGKFYSTSMVTI 1970
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY 609
V + D+ F + Y ++ EN ++T++ + A N + YSI++ G+
Sbjct: 1971 MVKEAMDSGLHFTQSFYSTSISENNTNITKVAIVNAVGNRL--NEPLKYSILNP---GNK 2025
Query: 610 FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
F I G + + P D E+ L L V A + + V V + + D NDN P
Sbjct: 2026 FKIKSTSGV-IQTTGVPFDREE--QELYELVVEASRELDHLRVARVVVRVNIEDINDNSP 2082
Query: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST-QFRINARSGEI 728
F Y+ +V + G + + A D D+ + Y L+ F IN SG +
Sbjct: 2083 VFVGLPYYAAVQVDAEPGTLIYQVTAIDKDKGPN---GEVTYVLQDDYGHFEINPNSGNV 2139
Query: 729 TTTSLLDRETKS-EYILIVRAVDGGVGHNQKTGIAT-VNITLLDINDNHPTWKDAPYYIN 786
+ + + EY + + A DGG K ++T V + + +N P + D P+Y
Sbjct: 2140 ILKEAFNSDLSNIEYGVTILAKDGG-----KPSLSTSVELPITIVNKAMPVF-DKPFYTA 2193
Query: 787 LVEMTPPDSDV---TTVVAVDPDLGENGTLVYSI--QPPNKFYSLNSTTGKIRTTHAMLD 841
V + D+ T +++++ E ++Y I P K ++++ TG ++
Sbjct: 2194 SV-----NEDIRMNTPILSINATSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVV----- 2243
Query: 842 RENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 901
+P +E K+ + +D A + TV + + D+NDN P F + + E
Sbjct: 2244 --SPLDYEVTSAYKLTIRASDA---LTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSE 2298
Query: 902 GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD--FLINSSSGVVVTTTELDRERIA 959
G + QVV+ID D N +V Y++ F I+SSSG+++T LD E +
Sbjct: 2299 ASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQ 2358
Query: 960 EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNC 1019
L+V + D+G P+ SS + I++ DVND P F +Y VSE PR V +
Sbjct: 2359 HCTLKVRSIDSGFPSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQA 2418
Query: 1020 TDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVG 1079
+D D L Y I GN F + + V+ + Y L + D
Sbjct: 2419 SDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDG---- 2474
Query: 1080 KRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWY 1139
T TA V + VL N P F QS+Y A V E++ G ++ ++ATD D G +G++ Y
Sbjct: 2475 -LFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDPGTYGQISY 2533
Query: 1140 RILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVE 1199
I++ + F I SNG ++ R LDRE + + D G + V V V
Sbjct: 2534 AIINDFAKDRFLID-SNGQVITTER-LDRENPLEGDVSIFVRALDGGGRTTFCTVRVIVV 2591
Query: 1200 DINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK---- 1255
D ND AP F +Y R +R G G V VQA D D G + Y + S A
Sbjct: 2592 DENDNAPQFMTVEY-RASVRADVGRGHLVTQVQAIDPDDGANSRITYSLYSEASVSVADL 2650
Query: 1256 FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN 1315
EID G ++T + T V A D P VYI +L F+
Sbjct: 2651 LEIDPDNGWMVTKGNFNQLKNTVLSFFVKAVDGGIPVKHSLIPVYIHVLPPETFLPSFTQ 2710
Query: 1316 ASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQG 1375
+ Y I E+ A+G+ + ++ N+ T + + +F I+ TG I +
Sbjct: 2711 SQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKG-GIFVIEQETGTIKLDK 2769
Query: 1376 LVDREKGDFYTLTVVADDGGPKVDS--TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCP 1433
+DRE + V A KVD TV V I VLD NDN P F+ +S + I E P
Sbjct: 2770 RLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTI-IMEGMP 2828
Query: 1434 VGQRVATVKAWDPDAGSNGQVVFSLASGN----IAGAFEIVTTNDSIGEVFVARPLDREE 1489
VG ++ V+A D D G+NGQV +SL S + + AF I + + G + + LD E
Sbjct: 2829 VGTKLTQVRAIDMDWGANGQVTYSLHSDSQPEKVMEAFNI---DSNTGWISTLKDLDHET 2885
Query: 1490 LDHYILQVVASDRGTP-PRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVV 1548
+ VVASD G ++ V + DINDN PV Y +V E+ G V
Sbjct: 2886 DPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEV-YRGNVKESDPPGEVVA 2944
Query: 1549 QVRATDRDIG-INSVLSYYITEGNKDMAFRMDRISGEIATRPAPP-DRERQSFYHLVATV 1606
+ DRD +N +SY+IT GN F + + E P DRE Q Y L T
Sbjct: 2945 VLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIYFLNITA 3004
Query: 1607 EDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGP 1666
D T + V V++ D NDN+P+ Q Y LL E + N ++ + A D D G
Sbjct: 3005 TDGLFVTQAM---VEVSVSDVNDNSPVCDQVAYTALLPEDIPS-NKIILKVSAKDADIGS 3060
Query: 1667 NGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTS 1726
NG + Y++ G+ + F +D G + LD E Y+L+ ATD R
Sbjct: 3061 NGYIRYSLY-GSGNSEFFLDPESGELKTLALLDRE-RIPVYSLMAKATDG----GGRFCQ 3114
Query: 1727 TTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDG 1786
+ L+ + D+NDN P F D+ + A D D G N +V YS+ D
Sbjct: 3115 SNIHLI-LEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVDPDIGINRKVVYSLADS 3173
Query: 1787 DPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM-PPLSSTMLVGIRVLDIN 1845
G F I G++ + + LDRE + YN+++ A D+ LSS V I VLDIN
Sbjct: 3174 AG-GVFSIDSSSGIIILEQP--LDREQQSSYNISVRATDQSPGQSLSSLTTVTITVLDIN 3230
Query: 1846 DNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATT 1905
DN PV +T+ E++ + V V A+ D G NA +T+ I +GN + F IN T
Sbjct: 3231 DNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSGNEQGKFKINPKT 3290
Query: 1906 GIVTVNRPLDRERIPEYKLTISVKDN--PENPRIARRDYDLLLIFLSDENDNHPLFTKST 1963
G ++V+ LD E + L + KD P +A + I L+D NDN P F++
Sbjct: 3291 GGISVSEVLDYELCKRFYLVVEAKDGGTPALSAVATVN-----INLTDVNDNPPKFSQDV 3345
Query: 1964 YQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVR 2022
Y A + E++ G + +L +A D D + + ++ G + F ++ G+V V+
Sbjct: 3346 YSAVISEDALVGDSVILL----IAEDVDSQPNGQIHFSIVNGDRDNEFTVDPVLGLVKVK 3401
Query: 2023 SGVIIDREAFSPPILELLLLAEDIGL--LNSTAHLLITILDDNDNRPTFSPATLTVHLLE 2080
+DRE S LL+ A D G+ ++STA + I I D NDN P F+PA T + E
Sbjct: 3402 KK--LDRERVSG--YSLLVQAVDSGIPAMSSTATVNIDISDVNDNSPVFTPANYTAVIQE 3457
Query: 2081 NCPPGFSVLQVTATDEDSGLNGE-LVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQES 2139
N P G S+LQ+ TD DS NG + I +G ++ + G++R E
Sbjct: 3458 NKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVLDPHGILRSA-VVFQHTESLE 3516
Query: 2140 YRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAI 2199
Y L V A D G + + + + + +P + + +E PG VI I A
Sbjct: 3517 YVLCVQAKDSGKPQQVSHTYIRVRVIEESTHKPTAIPLEIFIVTMEDDFPGGVIGKIHAT 3576
Query: 2200 DHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLS 2259
D D+ Y ++ K + Q+ F VN + G ++ ++ Y + +S
Sbjct: 3577 DQDM-----YDVLTFALKSE-------QKSLFKVNSHDGKIIALGGLDS---GKYVLNVS 3621
Query: 2260 VIDNASDLP 2268
V D +P
Sbjct: 3622 VSDGRFQVP 3630
Score = 587 bits (1514), Expect = e-167
Identities = 609/2263 (26%), Positives = 995/2263 (43%), Gaps = 270/2263 (11%)
Query: 720 RINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWK 779
RI + G +++L+RE + Y+LIV+ G V VNI +LD+ND P +
Sbjct: 106 RIRTKGGN---SAILNREIQDNYLLIVK---GSVRGEDLEAWTKVNIQVLDMNDLRPLFS 159
Query: 780 DAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAM 839
Y + + E TP + V V A D D+G NG Y + +S++ T+G I +
Sbjct: 160 PTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFKNKVDLFSVHPTSGVISLS-GR 218
Query: 840 LDRENPDPHEAELMRKIVVSVTDCGRPPLK---ATSSATVFVNLLDLNDNDPTFQNLPFV 896
L+ + + ++ E++ D G +S+A ++V++ +N++ PT + V
Sbjct: 219 LNYDEKNRYDLEIL------AVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTHV 272
Query: 897 AEVLEGIPAGVSIYQVVAID-LDEGLNGLV-SYRMPVGMPRMDFLINSSSGVVVTTTELD 954
LE P Y VV +D LD+G NG + S + G P F + + +
Sbjct: 273 PFSLEKEPT----YAVVTVDDLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKE 328
Query: 955 RERIA------EYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPA-VYNVSVSED 1007
R++I Y L + A D G+P K S D P F VY+VS+SE
Sbjct: 329 RKQIDWESFPYGYNLTLQAKDKGSPQKCSALKAVYIGNPTRDTVPIRFEKEVYDVSISEF 388
Query: 1008 VPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYM 1067
P V + + + ++ Y ++ G F + R ++ T L+ Y
Sbjct: 389 SPPGVVVAIVKLSPEPI----DVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYK 444
Query: 1068 LILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKAT 1127
L + K A V +++ D ND+ P F Q Y+A V E +P G S+L + A+
Sbjct: 445 LEV-------TNKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSAS 497
Query: 1128 DADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSS-HVLIVEA------ 1180
D D+GE G + Y I N F I+ G++ LD E + + IV A
Sbjct: 498 DKDKGENGYITYSIASLNL-LPFVINQFTGVIST-TEELDFESSPEIYRFIVRASDWGSP 555
Query: 1181 YNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGD 1240
Y H+ S V V + + ++ND +P+F + + + +G + V A D D +
Sbjct: 556 YRHE-----SEVNVTIRIGNVNDNSPLFEKVACQGV-ISYDFPVGGHITAVSAIDIDELE 609
Query: 1241 GGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYE--TKTSYMMNVSATD---QAPPFNQ 1294
LV Y+I+SG E G F ++ +G++ L ++ + ++ATD A P
Sbjct: 610 --LVKYKIISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLADPM-- 665
Query: 1295 GFCSVYITLLNELDEAVQFS---------------------------------------- 1314
S+ I++L+ + FS
Sbjct: 666 ---SINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQG 722
Query: 1315 -----NASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITG 1369
+ + A+ E+L +G I++++AY D+ F + + F ID TG
Sbjct: 723 PYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNGKVLF-TISDGNTDSCFNIDMETG 781
Query: 1370 VITVQGLVDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSI 1428
+ V +DRE D Y L + + D G P+ S + I V D NDNSP F +V+I
Sbjct: 782 QLKVLMPMDREHTDLYLLNITIYDLGNPQKSSWRLLTINVEDANDNSPVF-IQDSYSVNI 840
Query: 1429 PEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE 1488
E +G + V+A D D GSNG+V +S+ + + N S G V+VA LDRE
Sbjct: 841 LESSGIGTEIIQVEARDKDLGSNGEVTYSVLTDT-----QQFAINSSTGIVYVADQLDRE 895
Query: 1489 ELDHYILQVVASDRGTPPRKKDHI--LQVTILDINDNPPVIESPFGYNVSVNENVGGGTA 1546
+Y L++ A D+ ++ + L+V + D+ND P P Y+V V E++ GT
Sbjct: 896 SKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAF-IPSSYSVKVLEDLPVGTV 954
Query: 1547 VVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATV 1606
+ + D D+G+ + Y + + + F +D+ SG I D E+Q FY+L
Sbjct: 955 IAWLETHDPDLGLGGQVRYSLV-NDYNGRFEIDKASGAIRL-SKELDYEKQQFYNLTVRA 1012
Query: 1607 EDEGTP-TLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDT-LNTSLITIQALDLDE 1664
+D+G P +LS+ + V V +VD N+N P + V+ ++ + TS++ + A D D
Sbjct: 1013 KDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTARDEDS 1072
Query: 1665 GPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRL 1724
G +G + Y+I G+ + F ID GVITAA LD E + G Y L V ATD+ + L
Sbjct: 1073 GRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRE-TMGSYWLTVYATDRGVV---PL 1128
Query: 1725 TSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIM 1784
ST V + V D+NDN P P + V A D DS N ++ Y I
Sbjct: 1129 YSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRIT 1188
Query: 1785 DGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDI 1844
G+P F I+ G++ +LDRE A + L + D G P ST+ V ++VLD
Sbjct: 1189 SGNPQNFFAINIKTGLITTTSR-KLDREQQAEHFLEVTVTDGGPSPKQSTIWVVVQVLDE 1247
Query: 1845 NDNDPVLLNLPMNITISE--NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFIN 1902
NDN P I + E + A D D G NA ++++I GN + FFI+
Sbjct: 1248 NDNKPQFPEKVYQIKLPERDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFID 1307
Query: 1903 ATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKS 1962
TG+V+ + + YD+L I D T
Sbjct: 1308 PKTGMVSSRK-----------------------QFTAGSYDILTIKAVDNGRPQKSSTAR 1344
Query: 1963 TYQAEVMENSPAGTPLT----VLNGPILALDADQDIYAVVTYQLLGAQ------SGLFD- 2011
+ + + P+ PLT N ++ D +I VV+ Q G FD
Sbjct: 1345 LHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRVTEIVGVVSVQPANTPLWFDIVGGNFDS 1404
Query: 2012 -INSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2070
++ GV T+ +D E S I + + D G + + I +LD+NDN P FS
Sbjct: 1405 AFDAEKGVGTIVIAKPLDAEQRS--IYNMSVEVTD-GTNVAVTQVFIKVLDNNDNGPEFS 1461
Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDS--GLNGELVYRIEAGAQDRFLIHLVTGVIRVG 2128
V + E+ P +LQ+ ATD D L+ + I++ + +F I TGV+
Sbjct: 1462 QPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTA 1521
Query: 2129 NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAE 2188
+D E Q+ + L ++ D+ A V + ++D ND P F NP+ SV ESA
Sbjct: 1522 E-RLDHEAQDKHILNIMVRDQEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFESAA 1580
Query: 2189 PGTVIANITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPM 2246
G+ + +TA+D D N +L Y I N + F + G + +
Sbjct: 1581 LGSAVLQVTALDKDKGENAELIYTIE-----------AGNTGNMFKIEPVLGIITICKEP 1629
Query: 2247 NRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERIL 2306
+ + + +++ V D S P S + A + ++V +++ P+F Y +
Sbjct: 1630 DMTTMGQFVLSIKVTDQGS--PPMSAT---AIVRISVTMSDNSHPKFIH---KDYQAEVN 1681
Query: 2307 EGATPGTTLIAVAAVD--------PDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANR 2358
E GT++I ++A+ D +NG+ T + +G + +
Sbjct: 1682 ENVDIGTSVILISAISQSTLIYEVKDGDINGIFTI--------------NPYSGVITTQK 1727
Query: 2359 TVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVG 2418
+DYE ++A++ A+ V ++IVD NDN P+F Y ++ E P+
Sbjct: 1728 ALDYERTSSYQLIIQATNMAG--MASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPIN 1785
Query: 2419 TII-------LTVTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKD 2469
+I+ L + ATDADS AL+ Y + + +K F ++ +TG I +++LD E
Sbjct: 1786 SIVRSLDNSPLVIRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIA 1845
Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI 2529
H+ +D+ + E+ V+V I+V DVND P F++ F T + G V+
Sbjct: 1846 HFHFHVHVRDSGSPQLT--AESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGVEVL 1903
Query: 2530 TMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDGGEP 2589
+ ATD D ELTYSL ++ F +D +SG++T + S + + L V +DG
Sbjct: 1904 KVSATDPDSEVPPELTYSLMEGSLDHFLIDSNSGVLTIKNNNLSKDHYMLIVKVSDG--- 1960
Query: 2590 PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDK-DEGLNGAV 2648
+ T+M+ + V + D+ F + T + +N+ +V + LN +
Sbjct: 1961 KFYSTSMVTIMVKEAMDSGLHFTQSFYSTSISEN-----NTNITKVAIVNAVGNRLNEPL 2015
Query: 2649 RYSFLKTAGNRDWEFFIIDPISGLIQ-TAQRLDRESQAVYSLILVASDLGQPVPYETMQP 2707
+YS L GN+ F I SG+IQ T DRE Q +Y L++ AS + +
Sbjct: 2016 KYSIL-NPGNK----FKIKSTSGVIQTTGVPFDREEQELYELVVEASRELDHLRVARV-V 2069
Query: 2708 LQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYF 2767
++V +EDI+DN P+FV G P Y + V + GTL+ VT A+D D+GPN V Y
Sbjct: 2070 VRVNIEDINDNSPVFV----GLPYYAAVQV--DAEPGTLIYQVT-AIDKDKGPNGEVTYV 2122
Query: 2768 IAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADL 2827
+ ++ +F + P+ ++L +EA S + + G P+L +L
Sbjct: 2123 LQ--DDYGHFEINPNSGNVIL------KEAFNSDLSNIEYGVTILAKDGGKPSLSTSVEL 2174
Query: 2828 TLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLA 2870
+ V N P F K YTA V D ++ + ++ + A
Sbjct: 2175 PITIV-------NKAMPVFDKPFYTASVNEDIRMNTPILSINA 2210
Score = 466 bits (1199), Expect = e-130
Identities = 477/1819 (26%), Positives = 829/1819 (45%), Gaps = 228/1819 (12%)
Query: 1244 VNYRILSG-AEGKFEIDESTGLIITVNY--------------LDYETKTSYMMNVSATDQ 1288
+ YRI+SG EG F+ +E +I ++ L+ E + +Y++ V + +
Sbjct: 79 IKYRIVSGDEEGFFKAEE----VIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVR 134
Query: 1289 APPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQI 1346
+ + V I +L+ D FS +Y I E+ L T + +V A D + +
Sbjct: 135 GEDL-EAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEF 193
Query: 1347 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPK------VDS 1400
Y F LF + +GVI++ G ++ ++ + Y L ++A D G K V S
Sbjct: 194 YYYFKNKVD-----LFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSS 248
Query: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVV-FSLA 1459
T K+Y+ + N+++P + S+ ++ A V D D G+NG++ S+
Sbjct: 249 TAKLYVHIERINEHAPTIHVVTHVPFSLEKE----PTYAVVTVDDLDDGANGEIESVSIV 304
Query: 1460 SGNIAGAFEIVTTNDSIGEVFVA--RPLDREELDH-YILQVVASDRGTPPRKKDHILQVT 1516
+G+ F + + E + + +D E + Y L + A D+G+P +K L+
Sbjct: 305 AGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSP--QKCSALKAV 362
Query: 1517 ILD--INDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDM 1574
+ D P+ Y+VS++E G V V+ + I + Y ++ G +
Sbjct: 363 YIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPIDVE----YKLSPGEDAV 418
Query: 1575 AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMF 1634
F+++ SG I T P + ++ Y L T EG V ++I D ND+ P F
Sbjct: 419 YFKINPRSGLIVTA-RPLNTVKKEVYKLEVT-NKEG----DLKAQVTISIEDANDHTPEF 472
Query: 1635 QQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITA 1694
QQP Y+ ++E + TS++T+ A D D+G NG +TY+I + N++ F I++ GVI+
Sbjct: 473 QQPLYDAYVNESVP-VGTSVLTVSASDKDKGENGYITYSIASLNLL-PFVINQFTGVIST 530
Query: 1695 AKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPR-------D 1747
+ELD+E S Y IV A+D H S V + + ++NDN P F +
Sbjct: 531 TEELDFESSPEIYRFIVRASDWGSPYRHE--SEVNVTIRIGNVNDNSPLFEKVACQGVIS 588
Query: 1748 YEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDV 1807
Y+ P G + A D D V+Y I+ G+ LG F ++P GVL+++K +
Sbjct: 589 YDFPV-------GGHITAVSAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSL 639
Query: 1808 ---------------ELDRETIA---FYNLTI-----------CARDRGMPPLSSTMLVG 1838
D E +A N+++ C R L+ +L+
Sbjct: 640 TNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIK 699
Query: 1839 IRV-------------LDINDNDPVL-LNLPMNITISENSPVSSFVAHVLASDADSGCNA 1884
+ IN P + P ++ + E+ PV + + + A DADSG N
Sbjct: 700 AKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDADSGFNG 759
Query: 1885 RLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD--NPENPRIARRDY 1942
++ F I+ GN + F I+ TG + V P+DRE Y L I++ D NP+ + +
Sbjct: 760 KVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQ-----KSSW 814
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL 2002
LL I + D NDN P+F + +Y ++E+S GT + + A D D VTY +
Sbjct: 815 RLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEII----QVEARDKDLGSNGEVTYSV 870
Query: 2003 LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDD 2062
L + F INSSTG+V V + + +A +E AE L S L + + D
Sbjct: 871 L-TDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDV 929
Query: 2063 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVT 2122
ND P F P++ +V +LE+ P G + + D D GL G++ Y + RF I +
Sbjct: 930 NDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKAS 989
Query: 2123 GVIRVGNATIDREEQESYRLTVVATDRG-TVPLSGTAIVTILIDDINDS--RPEFLNPIQ 2179
G IR+ + +D E+Q+ Y LTV A D+G V LS + V + + D+N++ P F +
Sbjct: 990 GAIRL-SKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAV 1048
Query: 2180 TVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINT 2237
SV E++ GT + +TA D D + +++Y I +D + F+++ +
Sbjct: 1049 VGSVKENSRIGTSVLQVTARDEDSGRDGEIQYSI-----RDGSGL------GRFSIDDES 1097
Query: 2238 GSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFG 2297
G + ++RE + +Y +T+ D +P S ++ + V DVNDN P
Sbjct: 1098 GVITAADILDRETMGSYWLTVYATDRGV-VPLYS----TIEVYIEVEDVNDNAPLTSE-- 1150
Query: 2298 ITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIAN 2357
Y ++E + ++I + A DPD N +TY + P + + + +
Sbjct: 1151 -PIYYPVVMENSPKDVSVIQIQAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLITTTS 1209
Query: 2358 RTVDYEE--VHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFE-- 2413
R +D E+ H+L TV +D G P+ + I V ++++D NDN P F + YQ + E
Sbjct: 1210 RKLDREQQAEHFLEVTV--TDGGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERD 1267
Query: 2414 DVPVGTIILTVTATDADSGNFALIEYSLGDG--ESKFAINPTTGDIYVLSSLDREKKDHY 2471
G I A D D G A I YS+ DG + KF I+P TG ++SS + Y
Sbjct: 1268 RKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKTG---MVSSRKQFTAGSY 1324
Query: 2472 -ILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP---QFSKPQFSTSVYENEPAGTS 2527
ILT A DN ++ ++ ++ I+ + P F +P ++ +V E++ T
Sbjct: 1325 DILTIKAVDN----GRPQKSSTARLHIEWIKKPPPSPIPLTFDEPFYNFTVMESDRV-TE 1379
Query: 2528 VITMMATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGLVTTQRPLQSYEK--FSLTVVAT 2584
++ +++ + N L + + G + AF + G + +PL + ++ ++++V T
Sbjct: 1380 IVGVVSV---QPANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSIYNMSVEVT 1436
Query: 2585 DGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGL 2644
DG T + ++V+D NDN P F +P + I E++ + + ++ ATD+DE
Sbjct: 1437 DGTNV---AVTQVFIKVLDNNDNGPEFSQP--NYDVTISEDVLPDTEILQIEATDRDE-- 1489
Query: 2645 NGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPY-E 2703
+ Y+ + + F IDP +G++ TA+RLD E+Q + L ++ D Q PY
Sbjct: 1490 KHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRD--QEFPYRR 1547
Query: 2704 TMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAI 2763
+ + V +ED +D+ P F +P Y+ +V E + G+ V VT A+D D+G NA
Sbjct: 1548 NLARVIVNVEDANDHSPYFT-----NPLYE-ASVFESAALGSAVLQVT-ALDKDKGENAE 1600
Query: 2764 VYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLD 2822
+ Y I AGN F ++P G + + ++ D F +K + S PP +
Sbjct: 1601 LIYTIEAGNTGNMFKIEPVLGIITICKEPDMTTMGQFVLSIKVTDQGS--PPMSATAI-- 1656
Query: 2823 LVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882
VR+ + ++ P+F +Y A V + +G+ +I + A+ + S +
Sbjct: 1657 ---------VRISVTMSDNSHPKFIHKDYQAEVNENVDIGTSVILISAI-----SQSTLI 1702
Query: 2883 YSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDLAGHND 2942
Y + D+ +FT+ G++ T + + I A ++AG
Sbjct: 1703 YEV-----------KDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQATNMAGMAS 1751
Query: 2943 TAIIGIYILRDDQRVKIVI 2961
A + I I+ ++ + +
Sbjct: 1752 NATVNIQIVDENDNAPVFL 1770
Score = 226 bits (577), Expect = 2e-58
Identities = 266/997 (26%), Positives = 429/997 (43%), Gaps = 132/997 (13%)
Query: 1959 FTKSTYQAEVMENSPAGTPLTVLNG-PILALDADQDI-YAVVTYQLLGAQSGLFD----I 2012
FT S Y A V ENS A T + + I +D DI Y +V+ G + G F I
Sbjct: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLIDLSWDIKYRIVS----GDEEGFFKAEEVI 98
Query: 2013 NSSTGVVTVR----SGVIIDREAFSPPILEL--LLLAEDIGLLNSTAHLLITILDDNDNR 2066
+ + +R + I++RE +L + + ED L + + I +LD ND R
Sbjct: 99 IADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVRGED---LEAWTKVNIQVLDMNDLR 155
Query: 2067 PTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIR 2126
P FSP T +V + E+ P SV QVTATD D G NGE Y + D F +H +GVI
Sbjct: 156 PLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK-NKVDLFSVHPTSGVIS 214
Query: 2127 VGNATIDREEQESYRLTVVATDR-----GTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
+ + ++ +E+ Y L ++A DR G +S TA + + I+ IN+ P ++ + V
Sbjct: 215 L-SGRLNYDEKNRYDLEILAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPT-IHVVTHV 272
Query: 2182 SVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVM 2241
EP + + +D N ++E V IVA D D+ +E + +N +
Sbjct: 273 PFSLEKEPTYAVVTVDDLDDGANGEIE--SVSIVAGDPLDQFFLAKEGKW---LNEYKIK 327
Query: 2242 VKSPMNRE-LVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKP--FGI 2298
+ ++ E Y +TL D S P + + + + T P F
Sbjct: 328 ERKQIDWESFPYGYNLTLQAKDKGS---------PQKCSALKAVYIGNPTRDTVPIRFEK 378
Query: 2299 TYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANR 2358
Y I E + PG ++A+ + P+ V Y L Y ++ S G ++ R
Sbjct: 379 EVYDVSISEFSPPG-VVVAIVKLSPEP---IDVEYKLSPGEDAVYFKINPRS-GLIVTAR 433
Query: 2359 TVD--YEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVP 2416
++ +EV+ L T + D + V + I D ND+ P F QP Y V E VP
Sbjct: 434 PLNTVKKEVYKLEVTNKEGD-------LKAQVTISIEDANDHTPEFQQPLYDAYVNESVP 486
Query: 2417 VGTIILTVTATDADSGNFALIEYSLGD-GESKFAINPTTGDIYVLSSLDREKKDHYILTA 2475
VGT +LTV+A+D D G I YS+ F IN TG I LD E
Sbjct: 487 VGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFI 546
Query: 2476 LAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATD 2535
+ + G + R E+ V V I++ +VND P F K + + P G + + A D
Sbjct: 547 VRASDWG--SPYRHESEVNVTIRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAID 604
Query: 2536 QDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQS----YEKFSLTVVATDG---GE 2588
DE + + G + F+++ DSG++ ++ L + F+L + ATDG +
Sbjct: 605 IDELELVKYKI-ISGNELGFFYLNPDSGVLQLKKSLTNSGIKNGNFALRITATDGENLAD 663
Query: 2589 PPLWGTTML---------------------------------------LVEVIDVNDNRP 2609
P ++L ++ +N P
Sbjct: 664 PMSINISVLHGKVSSKSFSCRETRVAQKLAEKLLIKAKANGKLNLEDGFLDFYSINRQGP 723
Query: 2610 VFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPI 2669
F + + ++E++P+ +N+ ++ A D D G NG V ++ + GN D F ID
Sbjct: 724 YFDKSFPSDVA-VKEDLPVGANILKIKAYDADSGFNGKVLFTI--SDGNTD-SCFNIDME 779
Query: 2670 SGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGS 2729
+G ++ +DRE +Y L + DLG P + + L + +ED +DN P+F++
Sbjct: 780 TGQLKVLMPMDREHTDLYLLNITIYDLGNP-QKSSWRLLTINVEDANDNSPVFIQDSYS- 837
Query: 2730 PQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLR 2789
+ + E S GT + V A D D G N V Y + ++ + G + V
Sbjct: 838 -----VNILESSGIGTEIIQVE-ARDKDLGSNGEVTYSVLTDTQQFAIN-SSTGIVYVAD 890
Query: 2790 DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKA 2849
LDRE +A +S ++A L + +TL +V L+D+ND P F +
Sbjct: 891 QLDRESKANYSLKIEARDK--------AESGQQLFSVVTL---KVFLDDVNDCSPAFIPS 939
Query: 2850 EYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
Y+ V D VG+ + + D D+G V YS++
Sbjct: 940 SYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV 976
Score = 210 bits (534), Expect = 2e-53
Identities = 230/919 (25%), Positives = 403/919 (43%), Gaps = 129/919 (14%)
Query: 2100 LNGELVYRIEAGAQDRF-----LIHLVTGVIRV-----GNATIDREEQESYRLTVVATDR 2149
L+ ++ YRI +G ++ F +I +R+ +A ++RE Q++Y L V + R
Sbjct: 75 LSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGSVR 134
Query: 2150 GTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEY 2209
G L V I + D+ND RP F +V++ ES T +A +TA D D+ E+
Sbjct: 135 GE-DLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEF 193
Query: 2210 HIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPE 2269
+ N+ D F+V+ +G + + +N + Y++ + +D L
Sbjct: 194 YYY-----------FKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKLYG 242
Query: 2270 RSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNG 2329
+ AKL V++ +N++ P + + + T V D D G NG
Sbjct: 243 NNGVSSTAKLYVHIERINEHAPTI------HVVTHVPFSLEKEPTYAVVTVDDLDDGANG 296
Query: 2330 LVTYTLL---DLVPPGYVQLEDS--SAGKVIANRTVDYEEVHW-LNFTVRASDNGSPPRA 2383
+ + D + ++ E + K+ + +D+E + N T++A D GSP +
Sbjct: 297 EIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAKDKGSPQKC 356
Query: 2384 AEIPVYLEIVDINDNNPI-FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLG 2442
+ + D PI F++ Y ++ E P G ++ V + +EY L
Sbjct: 357 SALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID----VEYKLS 412
Query: 2443 DGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVL 2500
GE F INP +G I L+ KK+ Y L K+ GD+ + QV I +
Sbjct: 413 PGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKE--GDLKA-------QVTISIE 463
Query: 2501 DVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDM 2560
D ND P+F +P + V E+ P GTSV+T+ A+D+D+G NG +TYS+ + F ++
Sbjct: 464 DANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLPFVINQ 523
Query: 2561 DSGLVTTQRPL---QSYEKFSLTVVATDGGEPPLWGTTM-LLVEVIDVNDNRPVFVRPPN 2616
+G+++T L S E + V A+D G P + + + + + +VNDN P+F +
Sbjct: 524 FTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVAC 583
Query: 2617 GTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTA 2676
+ I + P+ ++ V A D DE V+Y + +GN + FF ++P SG++Q
Sbjct: 584 QGV--ISYDFPVGGHITAVSAIDIDE--LELVKYKII--SGN-ELGFFYLNPDSGVLQLK 636
Query: 2677 QRLDRE--SQAVYSLILVASD---LGQPVPY-----------------ETMQPLQVALE- 2713
+ L ++L + A+D L P+ ET ++A +
Sbjct: 637 KSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLAEKL 696
Query: 2714 ----------DIDDNEPLFVRPPKGSPQYQL-----LTVPEHSPRGTLVGNVTGAVDADE 2758
+++D F + P + + V E P G + + A DAD
Sbjct: 697 LIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIK-AYDADS 755
Query: 2759 GPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGP 2817
G N V + I+ GN + F++ + G L VL +DRE + +++ + P +
Sbjct: 756 GFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDL--YLLNITIYDLGNPQKS- 812
Query: 2818 SPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGN 2877
+ + + + +ED ND P F + Y+ + + +G+E+IQV A D D+G+
Sbjct: 813 ----------SWRLLTINVEDANDNSPVFIQDSYSVNILESSGIGTEIIQVEARDKDLGS 862
Query: 2878 NSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARDL 2937
N V YS+L D+ Q F + S GI+ D S + + I ARD
Sbjct: 863 NGEVTYSVL---------TDT----QQFAINSSTGIVYVADQLDRESKANYSLKIEARDK 909
Query: 2938 A--GHNDTAIIGIYILRDD 2954
A G +++ + + DD
Sbjct: 910 AESGQQLFSVVTLKVFLDD 928
Score = 129 bits (324), Expect = 5e-29
Identities = 156/592 (26%), Positives = 259/592 (43%), Gaps = 65/592 (10%)
Query: 1024 VGLNAELSYFITGGNVDGKFSV------GYRDAVVRTVVG----LDRETTAAYMLILEAI 1073
+ L+ ++ Y I G+ +G F + +RT G L+RE Y+LI++
Sbjct: 73 IDLSWDIKYRIVSGDEEGFFKAEEVIIADFCFLRIRTKGGNSAILNREIQDNYLLIVKGS 132
Query: 1074 DNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGE 1133
G + T V + VLD+ND RP+F ++Y ++ E P S+ Q+ ATDAD G
Sbjct: 133 VRGEDLEAWT---KVNIQVLDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGS 189
Query: 1134 FGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL-----GPM 1188
G +Y N + F +H ++G++ R L+ + + + L + A + + +
Sbjct: 190 NGEFYYYFK--NKVDLFSVHPTSGVISLSGR-LNYDEKNRYDLEILAVDRGMKLYGNNGV 246
Query: 1189 RSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG-DGGLVNYR 1247
S+ ++ V++E IN+ AP + L + + VV D D G +G + +
Sbjct: 247 SSTAKLYVHIERINEHAPTIHVVTHVPFSLEKEP----TYAVVTVDDLDDGANGEIESVS 302
Query: 1248 ILSG---------AEGKFEIDESTGLIITVNYLDYET-KTSYMMNVSATDQAPPFN-QGF 1296
I++G EGK+ + I +D+E+ Y + + A D+ P
Sbjct: 303 IVAGDPLDQFFLAKEGKWLNEYK---IKERKQIDWESFPYGYNLTLQAKDKGSPQKCSAL 359
Query: 1297 CSVYITLLNELDEAVQFSNASYEAAILENLALGT--EIVRVQAYSIDNLNQITYRFNAYT 1354
+VYI ++F Y+ +I E G IV++ ID + Y+ +
Sbjct: 360 KAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEPID----VEYKLSP-- 413
Query: 1355 STQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDN 1414
+ FKI+ +G+I ++ K + Y L V +G D +V I++ D ND+
Sbjct: 414 -GEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEG----DLKAQVTISIEDANDH 468
Query: 1415 SPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTND 1474
+P F A + E PVG V TV A D D G NG + +S+AS N+ N
Sbjct: 469 TPEFQQPLYDAY-VNESVPVGTSVLTVSASDKDKGENGYITYSIASLNLLP----FVINQ 523
Query: 1475 SIGEVFVARPLDREEL-DHYILQVVASDRGTPPRKKDHI-LQVTILDINDNPPVIESPFG 1532
G + LD E + Y V ASD G+P R + + + + I ++NDN P+ E
Sbjct: 524 FTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLFEKVAC 583
Query: 1533 YNV-SVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISG 1583
V S + VGG V DI ++ Y I GN+ F ++ SG
Sbjct: 584 QGVISYDFPVGGHITAVSA----IDIDELELVKYKIISGNELGFFYLNPDSG 631
>gi|13787217 FAT tumor suppressor 2 precursor [Homo sapiens]
Length = 4349
Score = 869 bits (2246), Expect = 0.0
Identities = 844/2953 (28%), Positives = 1346/2953 (45%), Gaps = 272/2953 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMDN-DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSE 100
I +D PVG S+ + A D+D L + + +F + +GV+ L++P T +
Sbjct: 573 IRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQ 632
Query: 101 ---FTVEFSVSDHQ---------------------------GVITRKV------------ 118
++++ + SD + GV+T+
Sbjct: 633 PTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQ 692
Query: 119 --------NIQVGDVNDNAPTFHNQ-PYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLY 169
++ +N P F + P S+ + E+ P+ TP+ + ATDPD G G ++Y
Sbjct: 693 ESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVY 752
Query: 170 SFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIIT 227
++ F I+ G++TV LDYE T Y L V D T S+ L + +
Sbjct: 753 VIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVTVYDLG-TPQKSSWKLLTVNVK 811
Query: 228 DVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALD 287
D D P F Y I E + GTT+ +T D D + YT++S F+L
Sbjct: 812 DWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEK--FSLH 869
Query: 288 YISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI-DINDNAP 346
++G L + G LDRE+ +IL V E D + + T I+ + D+NDN+P
Sbjct: 870 PLTGELVVTGHLDRES---EPRYILKV---EARDQPSKGHQLFSVTDLIITLEDVNDNSP 923
Query: 347 EFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQ 406
+ + + + E G L F+ D D L EV V + H +
Sbjct: 924 QCITEHNRLKVPEDLPPGTVLT-FLDASDPD----LGPAGEVRYVLMDGAHGTFRVDLMT 978
Query: 407 GKADIRIRVAIPLDYETVDRYDFDLFANES----VPDHVGYAKVKITLINENDNRPIFSQ 462
G + LD+E Y+ L+A++ + + +V + +NEN + P F+
Sbjct: 979 GALILERE----LDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNENLHPPHFAS 1034
Query: 463 PLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPD--RFSLDKDTGLIMLIAR 520
++ + EN GT V+ V A D+D+G GE+ YF FS+++DTG+I +A
Sbjct: 1035 FVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAP 1094
Query: 521 LDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEPSVT 578
LD E + LT++A D G + V I V D NDN P + + +++E+ P T
Sbjct: 1095 LDREFASYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGT 1154
Query: 579 QLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIY 638
+++L A D DS ++T++I S + G + ++ G++S ++ LD E ++
Sbjct: 1155 SVLQLDAWDPDSSSKGKLTFNITSGNYMGFFM---IHPVTGLLSTAQQLDRENKDEHILE 1211
Query: 639 LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI--MAGATVLFLNAT 696
+TV+ D G P L ST V + + D NDNPP FS + V + E + ++ V L A+
Sbjct: 1212 VTVL--DNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVAS 1269
Query: 697 DLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEY-ILIVRAVDGGV 753
DLD + YS+E S + F I+ +G ++++S T EY IL ++A D G
Sbjct: 1270 DLDEGLN---GRVTYSIEDSDEEAFSIDLVTGVVSSSSTF---TAGEYNILTIKATDSG- 1322
Query: 754 GHNQKTGIATVNITLLDIN----DNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGE 809
Q A+V + + I + P D YY V T P + + V++V+ G
Sbjct: 1323 ---QPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE---GR 1376
Query: 810 NGTLVYSIQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867
G ++I +K + + TTG I + R + + + V VTD R
Sbjct: 1377 PGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYN-------LTVEVTDGSRT- 1428
Query: 868 LKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927
+ +F+ + ++N + P F + V + GV + +V AID D+G + + +
Sbjct: 1429 --IATQVHIFM-IANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTI 1485
Query: 928 R--MPVGMPRMDFLINSSSGVVVTTTELDR-ERIAEYQLRVVASDAGTPTKSSTSTLTIH 984
G + F ++ SSGV+VT +LD +++ L V+ D P K + +TIH
Sbjct: 1486 HGSQDPGSASL-FQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIH 1544
Query: 985 VLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFS 1044
V D N P F Y SV + + ++ + D D G+NAE+ Y + GN +G F+
Sbjct: 1545 VEDGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFN 1604
Query: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
+ ++ LD+ A + L ++A D G + ATV + V + + PIF +
Sbjct: 1605 INALLGIITLAQKLDQANHAPHTLTVKAEDQG--SPQWHDLATVIIHVYPSDRSAPIFSK 1662
Query: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPR 1164
S Y +PE IP G IL + A E V Y + GN F ++ +GL+ +
Sbjct: 1663 SEYFVEIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLIST-QK 1716
Query: 1165 PLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGI 1224
LD E+ SS+ L + N + + V V+V + D ND AP+F + + + E A +
Sbjct: 1717 KLDHEKISSYQLKIRGSN--MAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQ-ISEAAPL 1773
Query: 1225 GTSVI-------VVQATDRDSGDGGLVNYRILSGAEGKF-EIDESTGLIITVNYLDYETK 1276
+ ++ V+ A+D D L+ Y+IL KF +ID S G + V+ +DYE+
Sbjct: 1774 YSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESM 1833
Query: 1277 TSYMMNVSATDQAPP--FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVR 1334
S+ V DQ P F V I + + D +FS YE AI+ + G E++
Sbjct: 1834 PSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLM 1893
Query: 1335 VQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDG 1394
V+A D+ ++ Y + +A I +TG I+V L G LT+ A DG
Sbjct: 1894 VRASDEDS--EVNYSIKTGNADEAVT---IHPVTGSISV--LNPAFLGLSRKLTIRASDG 1946
Query: 1395 GPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQV 1454
+ + VK+ +T + D S +FD A ++ E+ + R A V N +
Sbjct: 1947 LYQDTALVKISLTQV--LDKSLQFDQDVYWA-AVKEN--LQDRKALVILGAQGNHLNDTL 2001
Query: 1455 VFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQ 1514
+ L +G F +V + + VA DRE+ D + L V D TP R +++
Sbjct: 2002 SYFLLNGT--DMFHMVQSAGVLQTRGVA--FDREQQDTHELAVEVRDNRTPQRVAQGLVR 2057
Query: 1515 VTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDM 1574
V+I D+NDNPP + Y + + G + QV ATD D+G N ++Y E
Sbjct: 2058 VSIEDVNDNPPKFKH-LPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAEDYT-- 2114
Query: 1575 AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMF 1634
FR+D G+I+ + P D + + YHL D GTP+L + V VT+ N + P+F
Sbjct: 2115 YFRIDPYLGDISLKK-PFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV--RNKSNPLF 2171
Query: 1635 QQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGT-VTYAIVAGNIVNTFRIDRHMGVIT 1693
Q P+Y+V + E TL T ++ QA P G + Y IV + F D GV+T
Sbjct: 2172 QSPYYKVRVPENI-TLYTPILHTQA----RSPEGLRLIYNIVEEEPLMLFTTDFKTGVLT 2226
Query: 1694 AAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFE 1753
LDYE S ++ V ATD + S TV V V D+NDN PTF +
Sbjct: 2227 VTGPLDYE-SKTKHVFTVRATDT----ALGSFSEATVEVLVEDVNDNPPTFSQ-LVYTTS 2280
Query: 1754 VTEGQPGPR-VWTFLAHDRDSGPNGQVEYSIM-DGDPLGEFVISPVEGVLRVRKDV-ELD 1810
++EG P V LA D+DSG N V Y I+ DG + +F + G V ELD
Sbjct: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFF--QINGSTGEMSTVQELD 2338
Query: 1811 RETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFV 1870
E +++ + A D+G PPL+ LV + V DINDN P +SE + V
Sbjct: 2339 YEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCGHLV 2398
Query: 1871 AHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
V A D DS +RL + I +GN++R FFIN+++GI+++ + Y L + D
Sbjct: 2399 LKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLDSSYNLRVGASD 2458
Query: 1931 NPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA 1990
+ + I ++ N P F + Y+AE+ EN+ GT + L LA+D
Sbjct: 2459 GVFRATVP------VYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDL----LAIDK 2508
Query: 1991 DQDIYAVVTYQLLGA-QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLL 2049
D Y + Y ++ S F IN + + T++ +DRE + ++ + ++A D G
Sbjct: 2509 DSGPYGTIDYTIINKLASEKFSINPNGQIATLQK---LDRENSTERVIAIKVMARDGGGR 2565
Query: 2050 NSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI- 2108
+ + I + D+NDN P F + TV + N V+QV A D D G N ++ Y +
Sbjct: 2566 VAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVN 2625
Query: 2109 -EAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI 2167
E +D I+ VTGV++V ++ + E Q + + A D G + V + +
Sbjct: 2626 PEDLVKDVIEINPVTGVVKVKDSLVGLENQ-TLDFFIKAQDGGPPHWNSLVPVRLQVVPK 2684
Query: 2168 NDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQ 2227
S P+F P+ T S E G+ I + A+ +P + + G + N+
Sbjct: 2685 KVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ-DPVIYSLVRGTTPES-------NK 2736
Query: 2228 EDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVN 2287
+ F+++ +TG + V+ PM+ E Y+ ID + + + V + + V DVN
Sbjct: 2737 DGVFSLDPDTGVIKVRKPMDHESTKLYQ-----IDVMAHCLQNTDVVSLVSVNIQVGDVN 2791
Query: 2288 DNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2347
DN P F+ Y + E GT++I V A+D D G +G V+Y L PG E
Sbjct: 2792 DNRPVFEA---DPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLS--ADPGSNVHE 2846
Query: 2348 ----DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPR-AAEIPVYLEIVDINDNNPIF 2402
DS +G + + +D E +F V A D+G + +++ V + I D NDN P F
Sbjct: 2847 LFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRF 2906
Query: 2403 DQPSYQEAVFEDVPVGTIILTVTATDADSG--NFALIEY-SLGDGESKFAINPTTGDIYV 2459
Y+ +V E+ G ++ T+ DAD N + Y + GD +F I+ GD +
Sbjct: 2907 ASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQV-GDEWR 2965
Query: 2460 LSS---LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFST 2516
+SS LDRE Y+L A D + + SV V I VLDVND PQ S+ ++
Sbjct: 2966 ISSRKTLDREHTAKYLLRVTASDG-------KFQASVTVEIFVLDVNDNSPQCSQLLYTG 3018
Query: 2517 SVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEK 2576
V+E+ G ++ + ATD D N ++TYSL GPG F +D +G +TT L K
Sbjct: 3019 KVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERK 3078
Query: 2577 --FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634
F+L ATDGG L VE DVNDN P F P+ + + + +++ V
Sbjct: 3079 DVFNLVAKATDGGGRSCQADITLHVE--DVNDNAPRFF--PSHCAVAVFDNTTVKTPVAV 3134
Query: 2635 VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS 2694
V+A D D+G N V YS +A F ID +G+I+ + L QA L + AS
Sbjct: 3135 VFARDPDQGANAQVVYSLPDSAEGH----FSIDATTGVIRLEKPLQVRPQAPLELTVRAS 3190
Query: 2695 DLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAV 2754
DLG P+P T+ + V++ ++D P+F+ + VPE +P GT V +
Sbjct: 3191 DLGTPIPLSTLGTVTVSVVGLEDYLPVFLNTEHS------VQVPEDAPPGTEVLQLATLT 3244
Query: 2755 DADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTP 2813
Y + +GNE+ F L G L V LD E + ++ S S
Sbjct: 3245 RPGAEKTG---YRVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSS--- 3298
Query: 2814 PRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDA 2873
++D+T V V + D+N+ P+F + Y+ V +A VG ++ V A D
Sbjct: 3299 --------SSLSDVT--TVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDE 3348
Query: 2874 DIGNNSLVFYSIL 2886
D NS + YS++
Sbjct: 3349 DGPLNSDITYSLI 3361
Score = 812 bits (2097), Expect = 0.0
Identities = 812/2924 (27%), Positives = 1317/2924 (45%), Gaps = 240/2924 (8%)
Query: 24 QVNRL-PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFA 79
Q+N P F +HF + + + E P+ + + +L A D D N LV+ ++ F
Sbjct: 706 QINHYTPQFEDHFPQS-IDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
Query: 80 VEPDTGVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFHNQP 136
+E +TG++ + PLD E + + + +V D Q + + + V D NDNAP F
Sbjct: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
Query: 137 YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYE 196
Y + I E+T VGT I + D D G V Y+ P++ F++ G + V LD E
Sbjct: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLLSPTEKFSLHPLTGELVVTGHLDRE 884
Query: 197 TTQAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTV 255
+ Y L V A DQ K L ++ +L I + DV D P I + E PPGT +
Sbjct: 885 SEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVL 944
Query: 256 RIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
+ A D D G + Y ++ G + F +D ++G L L LD E G+ L++
Sbjct: 945 TFLDASDPDLGPAGEVRYVLMDG-AHGTFRVDLMTGALILERELDFER---RAGYNLSLW 1000
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDN--APEFNSSEYSVAITELAQVGFALPLFIQV 373
+D P ++V+D+N+N P F S + + E + G + I V
Sbjct: 1001 A---SDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQV---IVV 1054
Query: 374 VDKDENLGLNSMFEVYL-VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLF 432
+D++ GL+ + +L G F I+ + I+ PLD E Y +
Sbjct: 1055 AAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGM------IQTLAPLDREFASYYWLTVL 1108
Query: 433 ANE--SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAG 490
A + SVP +V I + + NDN P SQ ++ S+ E+ VGTSVL + A D D+
Sbjct: 1109 AVDRGSVP-LSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSS 1167
Query: 491 TFGEVSYFFSDD--PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGR 546
+ G++++ + F + TGL+ +LD E L + D G ++T R
Sbjct: 1168 SKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSR 1227
Query: 547 VRINVLDVNDNVPTFQKDAYVGALRENEPSVT--QLVRLRATDEDSPPNNQITYSIVSAS 604
V + +LDVNDN P F + L E V+ + RL A+D D N ++TYSI +
Sbjct: 1228 VVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSD 1287
Query: 605 AFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFD- 663
F I L GV+S S + + LT+ A D+G PPL+++V + IE
Sbjct: 1288 E--EAFSIDLVT--GVVSSSSTFTAGEYN----ILTIKATDSGQPPLSASVRLHIEWIPW 1339
Query: 664 --ENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-YSLEGSTQ-- 718
+ P F + Y +V+E V ++ G+ + +++ G +
Sbjct: 1340 PRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVE--------GRPGLFWFNISGGDKDM 1391
Query: 719 -FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLL-DINDNHP 776
F I +G I LD +S Y L V DG +T V+I ++ +IN + P
Sbjct: 1392 DFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG-----SRTIATQVHIFMIANINHHRP 1446
Query: 777 TWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI---QPPN--KFYSLNSTTG 831
+ + Y + + + T P ++ V A+D D G+ +L+Y+I Q P + L+ ++G
Sbjct: 1447 QFLETRYEVRVPQDTVPGVELLRVQAIDQDKGK--SLIYTIHGSQDPGSASLFQLDPSSG 1504
Query: 832 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 891
+ T + P H + V V D P+K + V +++ D N + P F
Sbjct: 1505 VLVTVGKLDLGSGPSQH------TLTVMVRD-QEIPIK-RNFVWVTIHVEDGNLHPPRFT 1556
Query: 892 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTT 951
L + A V + I G + QV A+D D G+N V Y + G F IN+ G++
Sbjct: 1557 QLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQ 1616
Query: 952 ELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPRE 1011
+LD+ A + L V A D G+P +T+ IHV + P F + Y V + E +P
Sbjct: 1617 KLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVG 1676
Query: 1012 FRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILE 1071
++ ++ +E++Y + GN DG FS+ ++ T LD E ++Y L +
Sbjct: 1677 SPILLVSAMS-----PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKIR 1731
Query: 1072 AIDNGPVGKRHTGTAT---VFVTVLDVNDNRPIFLQSSYEASVPEDIP-------EGHSI 1121
G G T V V ++D NDN P+FL+S++ + E P + ++
Sbjct: 1732 -------GSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNP 1784
Query: 1122 LQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAY 1181
+ A+D+D+ + Y+IL F+I S G L +D E S V Y
Sbjct: 1785 FVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTI-VSEMDYESMPSFQFCV--Y 1841
Query: 1182 NHDLG-PMRSSVR---VIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1237
HD G P+ + R VI++V D+ND P F++Q Y + + G +++V+A+D D
Sbjct: 1842 VHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIY-EVAIVGPIHPGMELLMVRASDED 1900
Query: 1238 SGDGGLVNYRILSG-AEGKFEIDESTGLIITVN--YLDYETKTSYMMNVSATDQAPPFNQ 1294
S VNY I +G A+ I TG I +N +L K + + A+D Q
Sbjct: 1901 SE----VNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRK----LTIRASD---GLYQ 1949
Query: 1295 GFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYT 1354
V I+L LD+++QF Y AA+ ENL +V + A ++LN +Y
Sbjct: 1950 DTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQG-NHLNDTL----SYF 2004
Query: 1355 STQAKALFKIDAITGVITVQGLV-DREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDEN 1412
+F + GV+ +G+ DRE+ D + L V V D+ P+ + V +++ D N
Sbjct: 2005 LLNGTDMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVN 2064
Query: 1413 DNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTT 1472
DN P+F + I + G + V A D D G+NG V + A +
Sbjct: 2065 DNPPKFKHLPYYTI-IQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAED-----YTYFRI 2118
Query: 1473 NDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFG 1532
+ +G++ + +P D + L+ Y L+V+A D GTP + + + VT+ N + P+ +SP+
Sbjct: 2119 DPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR--NKSNPLFQSPY- 2175
Query: 1533 YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPP 1592
Y V V EN+ T ++ +A + G+ L Y I E M F D +G + T P
Sbjct: 2176 YKVRVPENITLYTPILHTQARSPE-GLR--LIYNIVEEEPLMLFTTDFKTG-VLTVTGPL 2231
Query: 1593 DRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNT 1652
D E ++ + D + S T V V + D NDN P F Q Y + EG T
Sbjct: 2232 DYESKTKHVFTVRATDTALGSFSEAT-VEVLVEDVNDNPPTFSQLVYTTSISEGLPA-QT 2289
Query: 1653 SLITIQALDLDEGPNGTVTYAIV--AGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLI 1710
+I + A D D G N V+Y IV ++ F+I+ G ++ +ELDYE + + +
Sbjct: 2290 PVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYE-AQQHFHVK 2348
Query: 1711 VTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE-GQPGPRVWTFLAH 1769
V A D+ LT T V+VNV+DINDN P F R + V+E G V A
Sbjct: 2349 VRAMDKG---DPPLTGETLVVVNVSDINDNPPEF-RQPQYEANVSELATCGHLVLKVQAI 2404
Query: 1770 DRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMP 1829
D DS ++EY I+ G+ F I+ G++ + + + + YNL + A D
Sbjct: 2405 DPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCK--KHLDSSYNLRVGASD---G 2459
Query: 1830 PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFN 1889
+T+ V I + N P ++EN+ V + V +LA D DSG + +
Sbjct: 2460 VFRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGTIDYT 2519
Query: 1890 ITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFL 1949
I F IN I T+ + LDRE E + I V R+A + + I L
Sbjct: 2520 IINKLASEKFSINPNGQIATLQK-LDRENSTERVIAIKVMARDGGGRVA---FCTVKIIL 2575
Query: 1950 SDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ--S 2007
+DENDN P F S Y + N +P+ +LA DAD+ A VTY +
Sbjct: 2576 TDENDNPPQFKASEYTVSIQSNVSKDSPVI----QVLAYDADEGQNADVTYSVNPEDLVK 2631
Query: 2008 GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAHLLITILDDNDN 2065
+ +IN TGVV V+ ++ L+ + A+D G NS + + ++ +
Sbjct: 2632 DVIEINPVTGVVKVKDSLV----GLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVPKKVS 2687
Query: 2066 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI--EAGAQDRFLIHLVTG 2123
P FS T E+ P G + V A + LV E+ F + TG
Sbjct: 2688 LPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTG 2747
Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
VI+V +D E + Y++ V+A + V I + D+ND+RP F +
Sbjct: 2748 VIKV-RKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPYKAVL 2806
Query: 2184 LESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVM 2241
E+ GT + +TAID D + ++ Y + N + FA++ +G +
Sbjct: 2807 TENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGS--------NVHELFAIDSESGWIT 2858
Query: 2242 VKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYY 2301
++ E TY + D+ + S A + V++ D NDN P+ F Y
Sbjct: 2859 TLQELDCETCQTYHFHVVAYDHGQTIQLSS----QALVQVSITDENDNAPR---FASEEY 2911
Query: 2302 MERILEGATPGTTLIAVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLED-SSAGKVIANRT 2359
++E + PG + + +D D N VT + + P G + ++ + +T
Sbjct: 2912 RGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSRKT 2971
Query: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
+D E V ASD A + V + ++D+NDN+P Q Y V EDV G
Sbjct: 2972 LDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHEDVFPGH 3028
Query: 2420 IILTVTATDADSGNFALIEYSL-GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAK 2478
IL V+ATD D+ A I YSL G G +F ++P TG++ L++LDRE+KD + L A A
Sbjct: 3029 FILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTALDRERKDVFNLVAKAT 3088
Query: 2479 DNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDE 2538
D G R + + V DVND P+F + +V++N T V + A D D+
Sbjct: 3089 DGGG------RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDPDQ 3142
Query: 2539 GPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ--SYEKFSLTVVATDGGEP-PLWGTT 2595
G N ++ YSL F +D +G++ ++PLQ LTV A+D G P PL
Sbjct: 3143 GANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLSTLG 3202
Query: 2596 MLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKT 2655
+ V V+ + D PVF+ + + + E+ P + V ++ + GA + +
Sbjct: 3203 TVTVSVVGLEDYLPVFLNTEHS--VQVPEDAPPGTEVLQLATLTRP----GAEKTGYRVV 3256
Query: 2656 AGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDI 2715
+GN F +D +G++ LD E+ Y L + S + + V + D+
Sbjct: 3257 SGNEQGR-FRLDARTGILYVNASLDFETSPKYFLSIECSRKSSS-SLSDVTTVMVNITDV 3314
Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEK 2775
+++ P F + P + V E++ G ++ V+ A D D N+ + Y + GN+
Sbjct: 3315 NEHRPQFPQDPYST------RVLENALVGDVILTVS-ATDEDGPLNSDITYSLIGGNQLG 3367
Query: 2776 NFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRV 2834
+F + P G L V + LDRE+ + +S ++A+ + P L D+ +Q
Sbjct: 3368 HFTIHPKKGELQVAKALDREQASSYSLKLRATDS--------GQPPLHEDTDIAIQ---- 3415
Query: 2835 VLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNN 2878
+ D+ND PPRF + Y+ V ++ +GS+++Q++ D D N
Sbjct: 3416 -VADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPEN 3458
Score = 775 bits (2002), Expect = 0.0
Identities = 796/2950 (26%), Positives = 1311/2950 (44%), Gaps = 268/2950 (9%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGE------EASRFFAVEPDTGVVWLRQPL 93
L ISEDT VG+++ +L +D D++ +G + F++ P TG + + L
Sbjct: 827 LTISEDTEVGTTIAELTTKDADSED-----NGRVRYTLLSPTEKFSLHPLTGELVVTGHL 881
Query: 94 DRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVG 148
DRE++ + ++ D HQ + I + DVNDN+P + +++PE+ P G
Sbjct: 882 DRESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPG 941
Query: 149 TPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNA 207
T + ++A+DPDLG G V Y + F +D G + + RELD+E Y L++ A
Sbjct: 942 TVLTFLDASDPDLGPAGEVRYVLMDGAHGTFRVDLMTGALILERELDFERRAGYNLSLWA 1001
Query: 208 TDQDKTRPLSTLANLAIIITDVQDM--DPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
+D + TL ++ +I+ DV + P F + + + E+SP GT V ++ A D D
Sbjct: 1002 SDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDS 1061
Query: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
G + Y + +G + F+++ +G++ LDRE Y +L V DR
Sbjct: 1062 GLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAV-------DRGS 1114
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
+ T I V D NDN P+ + + + +I E A VG ++ L + D D +
Sbjct: 1115 VPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSV-LQLDAWDPDSSSKGKLT 1173
Query: 386 FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDHVGYA 444
F + GN F+I P + + A LD E D + ++ + P +
Sbjct: 1174 FNI-TSGNYMGFFMIHPVTGL------LSTAQQLDRENKDEHILEVTVLDNGEPSLKSTS 1226
Query: 445 KVKITLINENDNRPIFSQPLYNISLYENVTVGTS--VLTVLATDNDAGTFGEVSYFFSD- 501
+V + +++ NDN PIFS L+N+ L E ++ + V ++A+D D G G V+Y D
Sbjct: 1227 RVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDS 1286
Query: 502 DPDRFSLDKDTGLIMLIARL---DYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNV 558
D + FS+D TG++ + +Y + LTI A D G + VR+++ + +
Sbjct: 1287 DEEAFSIDLVTGVVSSSSTFTAGEYNI-----LTIKATDSGQPPLSASVRLHI----EWI 1337
Query: 559 PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDIS----- 613
P + + A E S T + E P N+ + V +F+IS
Sbjct: 1338 PWPRPSSIPLAFDETYYSFTVM-------ETDPVNHMVGVISVEGRPGLFWFNISGGDKD 1390
Query: 614 ----LYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVF---DEND 666
+ + G I ++RPLD + SN LTV D T+ + +F + N
Sbjct: 1391 MDFDIEKTTGSIVIARPLDTRRRSN--YNLTVEVTDGSR-----TIATQVHIFMIANINH 1443
Query: 667 NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ------FR 720
+ P F + Y V V ++ + G +L + A D D+ + S+IY++ GS F+
Sbjct: 1444 HRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGK-----SLIYTIHGSQDPGSASLFQ 1498
Query: 721 INARSGEITTTSLLDRET-KSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWK 779
++ SG + T LD + S++ L V D + K V I + D N + P +
Sbjct: 1499 LDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPI--KRNFVWVTIHVEDGNLHPPRFT 1556
Query: 780 DAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTGKIRTTH 837
Y ++ + P +++ V A+D D G N + YS+ N F+++N+ G I T
Sbjct: 1557 QLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGII-TLA 1615
Query: 838 AMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVA 897
LD+ N PH + V D G P ATV +++ + + P F +
Sbjct: 1616 QKLDQANHAPHT------LTVKAEDQGSPQWH--DLATVIIHVYPSDRSAPIFSKSEYFV 1667
Query: 898 EVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRER 957
E+ E IP G I V A+ E V+Y + G F +NS SG++ T +LD E+
Sbjct: 1668 EIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLISTQKKLDHEK 1722
Query: 958 IAEYQLRVVASD-AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW 1016
I+ YQL++ S+ AG T + + ++D ND P F + + +SE P ++
Sbjct: 1723 ISSYQLKIRGSNMAGAFTDVM---VVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMD 1779
Query: 1017 LN-------CTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLI 1069
N +D+D N+ L Y I F + + V +D E+ ++
Sbjct: 1780 KNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFC 1839
Query: 1070 LEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDA 1129
+ D G A V + V DVND+ P F + YE ++ I G +L ++A+D
Sbjct: 1840 VYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDE 1899
Query: 1130 DEGEFGRVWYRILHGNHGNNFRIH-VSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPM 1188
D V Y I GN IH V+ + + P L R L + A + G
Sbjct: 1900 DS----EVNYSIKTGNADEAVTIHPVTGSISVLNPAFLGLSRK----LTIRASD---GLY 1948
Query: 1189 RSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRI 1248
+ + V + + + D++ F Q Y ++E +++++ A D ++Y +
Sbjct: 1949 QDTALVKISLTQVLDKSLQFDQDVYWA-AVKENLQDRKALVILGAQGNHLND--TLSYFL 2005
Query: 1249 LSGAEGKFEIDESTGLIITVNY-LDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNEL 1307
L+G + F + +S G++ T D E + ++ + V D P V +++ +
Sbjct: 2006 LNGTD-MFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRTPQRVAQGLVRVSIEDVN 2064
Query: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKID 1365
D +F + Y I + G + +V A D +TY F + F+ID
Sbjct: 2065 DNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEF-----AEDYTYFRID 2119
Query: 1366 AITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDS 1424
G I+++ D + + Y L V+A DGG P + S +V +TV N ++P F +
Sbjct: 2120 PYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV--RNKSNPLFQ-SPYY 2176
Query: 1425 AVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARP 1484
V +PE+ + + +A P+ ++++++ F TT+ G + V P
Sbjct: 2177 KVRVPENITLYTPILHTQARSPEGL---RLIYNIVEEEPLMLF---TTDFKTGVLTVTGP 2230
Query: 1485 LDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGG 1544
LD E ++ V A+D + + +V + D+NDNPP S Y S++E +
Sbjct: 2231 LDYESKTKHVFTVRATDTALGSFSEATV-EVLVEDVNDNPPTF-SQLVYTTSISEGLPAQ 2288
Query: 1545 TAVVQVRATDRDIGINSVLSYYITEGNKDMA--FRMDRISGEIATRPAPPDRERQSFYHL 1602
T V+Q+ A+D+D G N +SY I E D++ F+++ +GE++T D E Q +H+
Sbjct: 2289 TPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMST-VQELDYEAQQHFHV 2347
Query: 1603 VATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDL 1662
D+G P L+ T V V + D NDN P F+QP YE + E T ++ +QA+D
Sbjct: 2348 KVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELA-TCGHLVLKVQAIDP 2406
Query: 1663 DEGPNGTVTYAIVAGNIVNTFRIDRHMGVIT----AAKELDYEISHGRYTLIVTATDQCP 1718
D + Y I++GN F I+ G+I+ K LD Y L V A+D
Sbjct: 2407 DSRDTSRLEYLILSGNQDRHFFINSSSGIISMFNLCKKHLD-----SSYNLRVGASDGV- 2460
Query: 1719 ILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQ 1778
+T V +N + N P F + G +V LA D+DSGP G
Sbjct: 2461 -----FRATVPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDLLAIDKDSGPYGT 2515
Query: 1779 VEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRE--TIAFYNLTICARDRGMPPLSSTML 1836
++Y+I++ +F I+P + ++K LDRE T + + ARD G T
Sbjct: 2516 IDYTIINKLASEKFSINPNGQIATLQK---LDRENSTERVIAIKVMARDGGGRVAFCT-- 2570
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRE 1896
V I + D NDN P ++I N S V VLA DAD G NA +T+++ +
Sbjct: 2571 VKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLV 2630
Query: 1897 RAFF-INATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
+ IN TG+V V L + L +K P + L + + +
Sbjct: 2631 KDVIEINPVTGVVKVKDSL--VGLENQTLDFFIKAQDGGPPHWNSLVPVRLQVVP-KKVS 2687
Query: 1956 HPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGA-QSGLFDINS 2014
P F++ Y E+ P G+ + ++ D IY++V + + G+F ++
Sbjct: 2688 LPKFSEPLYTFSAPEDLPEGSEIGIVKA---VAAQDPVIYSLVRGTTPESNKDGVFSLDP 2744
Query: 2015 STGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATL 2074
TGV+ VR + D E+ ++++ + S + I + D NDNRP F
Sbjct: 2745 DTGVIKVRKPM--DHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVNDNRPVFEADPY 2802
Query: 2075 TVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEA----GAQDRFLIHLVTGVIRVGNA 2130
L EN P G SV+QVTA D+D+G +G++ YR+ A + F I +G I
Sbjct: 2803 KAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDSESGWITTLQE 2862
Query: 2131 TIDREEQESYRLTVVATDRG-TVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEP 2189
+D E ++Y VVA D G T+ LS A+V + I D ND+ P F + SV+E++EP
Sbjct: 2863 -LDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEP 2921
Query: 2190 GTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRE 2249
G ++A + +D D++ + I D + +Q + + + ++RE
Sbjct: 2922 GELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVG------DEWRISSRKTLDRE 2975
Query: 2250 LVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGA 2309
A Y + ++ D + SV+V + VLDVNDN+PQ Y ++ E
Sbjct: 2976 HTAKYLLRVTASDGKF---QASVTVE-----IFVLDVNDNSPQCSQL---LYTGKVHEDV 3024
Query: 2310 TPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE-DSSAGKVIANRTVDYEEVHWL 2368
PG ++ V+A D D N +TY+L PG + + D G++ +D E
Sbjct: 3025 FPGHFILKVSATDLDTDTNAQITYSLHG---PGAHEFKLDPHTGELTTLTALDRERKDVF 3081
Query: 2369 NFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATD 2428
N +A+D G R+ + + L + D+NDN P F AVF++ V T + V A D
Sbjct: 3082 NLVAKATDGGG--RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARD 3139
Query: 2429 ADSGNFALIEYSLGDG-ESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASN 2487
D G A + YSL D E F+I+ TTG I + L + LT A D + +
Sbjct: 3140 PDQGANAQVVYSLPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVRASDLGTPIPLS 3199
Query: 2488 RRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYS 2547
V + V+ + D P F + S V E+ P GT V+ + + P E T
Sbjct: 3200 TLGT---VTVSVVGLEDYLPVFLNTEHSVQVPEDAPPGTEVLQLATLTR---PGAEKTGY 3253
Query: 2548 LEGPGVEA--FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVID 2603
G E F +D +G++ L ++ K+ L++ + L T ++V + D
Sbjct: 3254 RVVSGNEQGRFRLDARTGILYVNASLDFETSPKYFLSIECSRKSSSSLSDVTTVMVNITD 3313
Query: 2604 VNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEF 2663
VN++RP F + P T + E + + V ATD+D LN + YS + G
Sbjct: 3314 VNEHRPQFPQDPYST--RVLENALVGDVILTVSATDEDGPLNSDITYSLI---GGNQLGH 3368
Query: 2664 FIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFV 2723
F I P G +Q A+ LDRE + YSL L A+D GQP +E + + + D++DN P F
Sbjct: 3369 FTIHPKKGELQVAKALDREQASSYSLKLRATDSGQPPLHEDTD-IAIQVADVNDNPPRFF 3427
Query: 2724 RPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYF-IAAGNEEKNFHLQPD 2782
+ + TV E+SP G+ V + + D D N Y F I GN F + PD
Sbjct: 3428 QLNYST------TVQENSPIGSKVLQLILS-DPDSPENGPPYSFRITKGNNGSAFRVTPD 3480
Query: 2783 GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQ 2842
G L+ L R + + ++AS S PP +L VRV + + +
Sbjct: 3481 GWLVTAEGLSRRAQEWYQLQIQASD--SGIPPLS-----------SLTSVRVHVTEQSHY 3527
Query: 2843 PPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVG 2902
P E V D G + ++ A D D + YS+ + E +G
Sbjct: 3528 APSALPLEIFITVGEDEFQGGMVGKIHATDRD--PQDTLTYSLA----------EEETLG 3575
Query: 2903 QVFTMGSMDG 2912
+ F++G+ DG
Sbjct: 3576 RHFSVGAPDG 3585
Score = 747 bits (1929), Expect = 0.0
Identities = 770/2805 (27%), Positives = 1263/2805 (45%), Gaps = 285/2805 (10%)
Query: 236 FINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR-GIGYTIVSGNTNSIFALD-YISGVL 293
F + Y+ IYE+S P T V + P+ + Y I+SG+ ++F + Y+ G
Sbjct: 33 FTHSHYNATIYENSSPKTYVESFEKMGIYLAEPQWAVRYRIISGDVANVFKTEEYVVGNF 92
Query: 294 TL---------NGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDN 344
LL+RE + L ++ TE + T + ++D ND
Sbjct: 93 CFLRIRTKSSNTALLNRE---VRDSYTLIIQATEKT-----LELEALTRVVVHILDQNDL 144
Query: 345 APEFNSSEYSVAITELAQVGFALPL---FIQVVDKDENLGLNSMFEVYLVGNNSHHFIIS 401
P F+ Y V I+E +PL +V D +LG N+ F Y S F I
Sbjct: 145 KPLFSPPSYRVTISE------DMPLKSPICKVTATDADLGQNAEF-YYAFNTRSEMFAIH 197
Query: 402 PTS----VQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNR 457
PTS V GK ++ R L VDR + + G+ + +++
Sbjct: 198 PTSGVVTVAGKLNVTWRGKHELQVLAVDRM-------RKISEGNGFGSLAALVVHVE--- 247
Query: 458 PIFSQPLYNISLY---ENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR-------FS 507
P +P S+ + GT+ TVL N +G E DP + ++
Sbjct: 248 PALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYA 307
Query: 508 LDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVR-INVLDVNDNVPTFQKDAY 566
+ L+ + E + F L++ AR G G ++R ++ + F+K Y
Sbjct: 308 RSNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVY 367
Query: 567 VGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRP 626
L E P +++V +R T + PN Q S + L G+I+ ++
Sbjct: 368 RVQLSEFSPPGSRVVMVRVTP--AFPNLQYVLKPSSENV-----GFKLNARTGLITTTKL 420
Query: 627 LDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA 686
+D+ ++ +++ +P STV V I++ D N++ P F++ +Y ++ ENI
Sbjct: 421 MDFHDRAHYQLHIRT------SPGQASTV-VVIDIVDCNNHAPLFNRSSYDGTLDENIPP 473
Query: 687 GATVLFLNATDLDRSREYGQES-IIYSLEG--STQFRINARSGEITTTSLLDRE-TKSEY 742
G +VL + ATD R++G+ + YS+ G + F I+ G I+T+ +D E K Y
Sbjct: 474 GTSVLAVTATD----RDHGENGYVTYSIAGPKALPFSIDPYLGIISTSKPMDYELMKRIY 529
Query: 743 ILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVA 802
VRA D G ++ + ++ + L ++NDN P +++ ++ + P + T+ A
Sbjct: 530 TFRVRASDWGSPFRREKEV-SIFLQLRNLNDNQPMFEEVNCTGSIRQDWPVGKSIMTMSA 588
Query: 803 VDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVS- 859
+D D +N L Y I N +++ LN +G I ++ P L KI S
Sbjct: 589 IDVDELQN--LKYEIVSGNELEYFDLNHFSGVISLKRPFINLTAGQPTSYSL--KITASD 644
Query: 860 --------------VTD--------CGRPPLKATSSATV--FVNLLDLNDNDPTFQNL-- 893
V D C + + + T+ F+ L + +D F +L
Sbjct: 645 GKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGLQNQESSDEEFTSLST 704
Query: 894 --------------PFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFL 939
P +VLE +P + ++ A D D G NG + Y + G F
Sbjct: 705 YQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGKLVYVIADGNEEGCFD 764
Query: 940 INSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAV 999
I +G++ LD E Y L V D GTP KSS LT++V D ND P F P
Sbjct: 765 IELETGLLTVAAPLDYEATNFYILNVTVYDLGTPQKSSWKLLTVNVKDWNDNAPRFPPGG 824
Query: 1000 YNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLD 1059
Y +++SED + L D D N + Y + + KFS+ + LD
Sbjct: 825 YQLTISEDTEVGTTIAELTTKDADSEDNGRVRYTLL--SPTEKFSLHPLTGELVVTGHLD 882
Query: 1060 RETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGH 1119
RE+ Y+L +EA D G + + +T+ DVNDN P + VPED+P G
Sbjct: 883 RESEPRYILKVEARDQPSKGHQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGT 942
Query: 1120 SILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVE 1179
+ L A+D D G G V Y ++ G HG FR+ + G L+ R LD ER + + L +
Sbjct: 943 VLTFLDASDPDLGPAGEVRYVLMDGAHG-TFRVDLMTGALIL-ERELDFERRAGYNLSLW 1000
Query: 1180 AYNHDLGPMRSSV-RVIVYVEDINDEA-PVFTQQQYSRLGLRETAGIGTSVIVVQATDRD 1237
A + R ++ V V V D+N+ P + ++E + GT VIVV A D D
Sbjct: 1001 ASDGGRPLARRTLCHVEVIVLDVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDD 1060
Query: 1238 SGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGF 1296
SG G + Y + +G F I++ TG+I T+ LD E + Y + V A D+
Sbjct: 1061 SGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPLSSV 1120
Query: 1297 CSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTST 1356
VYI + + D Q S A + +I E+ +GT ++++ A+ D+ ++ FN TS
Sbjct: 1121 TEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFN-ITSG 1179
Query: 1357 QAKALFKIDAITGVITVQGLVDREKGDFYTLTV-VADDGGPKVDSTVKVYITVLDENDNS 1415
F I +TG+++ +DRE D + L V V D+G P + ST +V + +LD NDN
Sbjct: 1180 NYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNP 1239
Query: 1416 PRFDFTSDSAVSIPED-CPVGQ-RVATVKAWDPDAGSNGQVVFSLA-SGNIAGAFEIVTT 1472
P F + V +PE PV V + A D D G NG+V +S+ S A + ++VT
Sbjct: 1240 PIFSHKLFN-VRLPERLSPVSPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTG 1298
Query: 1473 NDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVI----- 1527
S F A ++ IL + A+D G PP L + + P I
Sbjct: 1299 VVSSSSTFTAG-------EYNILTIKATDSGQPPLSASVRLHIEWIPW-PRPSSIPLAFD 1350
Query: 1528 ESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIAT 1587
E+ + + V + V V+ V G + + I+ G+KDM F +++ +G I
Sbjct: 1351 ETYYSFTVMETDPVNHMVGVISVE------GRPGLFWFNISGGDKDMDFDIEKTTGSIVI 1404
Query: 1588 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGP 1647
P D R+S Y+L V D G+ T++ H+++ I + N + P F + YEV + +
Sbjct: 1405 -ARPLDTRRRSNYNLTVEVTD-GSRTIATQVHIFM-IANINHHRPQFLETRYEVRVPQ-- 1459
Query: 1648 DTL-NTSLITIQALDLDEGPNGTVT-YAIVAGNIVNTFRIDRHMGVITAAKELDYEISHG 1705
DT+ L+ +QA+D D+G + T + + F++D GV+ +LD
Sbjct: 1460 DTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPS 1519
Query: 1706 RYTLIVTATDQ-CPILSHRLTSTTTVLVNVNDINDNVPTFPR-DYEGPFEVTEGQPGPRV 1763
++TL V DQ PI + V ++V D N + P F + YE T PG +
Sbjct: 1520 QHTLTVMVRDQEIPI----KRNFVWVTIHVEDGNLHPPRFTQLHYEASVPDTIA-PGTEL 1574
Query: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823
A D D G N +V YS++ G+ G F I+ + G++ + + +LD+ A + LT+ A
Sbjct: 1575 LQVRAMDADRGVNAEVHYSLLKGNSEGFFNINALLGIITLAQ--KLDQANHAPHTLTVKA 1632
Query: 1824 RDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCN 1883
D+G P V I V + + P+ + I E+ PV S + V A
Sbjct: 1633 EDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEIPESIPVGSPILLVSAMSP----- 1687
Query: 1884 ARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYD 1943
+ +T+ + GN++ F +N+ +G+++ + LD E+I Y+L I N A D
Sbjct: 1688 SEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKISSYQLKI----RGSNMAGAFTDV- 1742
Query: 1944 LLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNG---PILALDADQDIYAVVTY 2000
++++ + DENDN P+F KST+ ++ E +P + + N I A D+D++ +++ Y
Sbjct: 1743 MVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVY 1802
Query: 2001 QLLGAQS-GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG----LLNSTAHL 2055
++L ++ F I+ S G +T ++ + + S P + + D G A +
Sbjct: 1803 KILEPEALKFFKIDPSMGTLT----IVSEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQV 1858
Query: 2056 LITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQD 2114
+I + D ND+ P FS V ++ PG +L V A+DEDS +N Y I+ G A +
Sbjct: 1859 IIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDEDSEVN----YSIKTGNADE 1914
Query: 2115 RFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF 2174
IH VTG I V N S +LT+ A+D TA+V I + + D +F
Sbjct: 1915 AVTIHPVTGSISVLNPAF---LGLSRKLTIRASDG---LYQDTALVKISLTQVLDKSLQF 1968
Query: 2175 LNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVN 2234
+ +V E+ + + + A + LN L Y ++ N D F +
Sbjct: 1969 DQDVYWAAVKENLQDRKALVILGAQGNHLNDTLSYFLL-------------NGTDMFHMV 2015
Query: 2235 INTGSVMVKS-PMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF 2293
+ G + + +RE T+E+ + V DN + P+R V + V++ DVNDN P+F
Sbjct: 2016 QSAGVLQTRGVAFDREQQDTHELAVEVRDNRT--PQR---VAQGLVRVSIEDVNDNPPKF 2070
Query: 2294 KPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGK 2353
K Y I +G PG L V+A D D G NG VTY + Y ++ D G
Sbjct: 2071 KHLP---YYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAE--DYTYFRI-DPYLGD 2124
Query: 2354 VIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFE 2413
+ + DY+ ++ + V A D G+P +E V + + N +NP+F P Y+ V E
Sbjct: 2125 ISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV--RNKSNPLFQSPYYKVRVPE 2182
Query: 2414 DVPVGTIILTVTATDADSGNFALIEYSLGDGE--SKFAINPTTGDIYVLSSLDREKKDHY 2471
++ + T IL T A S + Y++ + E F + TG + V LD E K +
Sbjct: 2183 NITLYTPIL---HTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKTKH 2239
Query: 2472 ILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITM 2531
+ T A D + E +V+V+++ DVND P FS+ ++TS+ E PA T VI +
Sbjct: 2240 VFTVRATDT---ALGSFSEATVEVLVE--DVNDNPPTFSQLVYTTSISEGLPAQTPVIQL 2294
Query: 2532 MATDQDEGPNGELTYSLEGPGVEA---FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDG 2586
+A+DQD G N +++Y + G + F ++ +G ++T + L ++ + F + V A D
Sbjct: 2295 LASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQELDYEAQQHFHVKVRAMDK 2354
Query: 2587 GEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNG 2646
G+PPL G T+++V V D+NDN P F +P ++ E V +V A D D
Sbjct: 2355 GDPPLTGETLVVVNVSDINDNPPEFRQPQYEA--NVSELATCGHLVLKVQAIDPDS--RD 2410
Query: 2647 AVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQ 2706
R +L +GN+D FF I+ SG+I + + Y+L + ASD +
Sbjct: 2411 TSRLEYLILSGNQDRHFF-INSSSGIISMFNLCKKHLDSSYNLRVGASD----GVFRATV 2465
Query: 2707 PLQVALEDIDDNEPLFVRPPKGSPQYQL----LTVPEHSPRGTLVGNVTGAVDADEGPNA 2762
P+ + + + K SP++Q + E++ GT V ++ A+D D GP
Sbjct: 2466 PVYINTTNAN----------KYSPEFQQHLYEAELAENAMVGTKVIDLL-AIDKDSGPYG 2514
Query: 2763 IVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLD 2822
+ Y I + F + P+G + L+ LDRE +K + D
Sbjct: 2515 TIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERVIAIKVMAR-------------D 2561
Query: 2823 LVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882
+ V+++L D ND PP+F +EYT + ++ S +IQVLA DAD G N+ V
Sbjct: 2562 GGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADVT 2621
Query: 2883 YSILAIHYFRALANDSEDVGQVFTMGSMDGI-LRTFDLFMAYSPG 2926
YS+ + + + G V S+ G+ +T D F+ G
Sbjct: 2622 YSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFFIKAQDG 2666
Score = 740 bits (1911), Expect = 0.0
Identities = 773/2921 (26%), Positives = 1253/2921 (42%), Gaps = 265/2921 (9%)
Query: 93 LDRETKSEFTVEFSVSDHQ---GVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT 149
L+RE + +T+ ++ +TR V + + D ND P F Y V I E+ P+ +
Sbjct: 107 LNREVRDSYTLIIQATEKTLELEALTRVV-VHILDQNDLKPLFSPPSYRVTISEDMPLKS 165
Query: 150 PIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
PI V ATD DLG Y+F S+ FAI G+VTV +L+ ++L V A
Sbjct: 166 PICKVTATDADLGQNAEFYYAFNTRSEMFAIHPTSGVVTVAGKLNVTWRGKHELQVLAV- 224
Query: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP---PGTTVRIITAIDQDKG 266
D+ R +S + V ++P P ++ P GTT + +D +
Sbjct: 225 -DRMRKISEGNGFGSLAALVVHVEPALRKPPAIASVVVTPPDSNDGTTYATV-LVDANSS 282
Query: 267 RPRGIGYTIVSGNTNSIFAL--DYI-SGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
+V G+ F Y S +L + D Y HGF L++ +
Sbjct: 283 GAEVESVEVVGGDPGKHFKAIKSYARSNEFSLVSVKDINWMEYLHGFNLSL---QARSGS 339
Query: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
P + F++ + ++ +F + Y V ++E + G + + ++V NL
Sbjct: 340 GPYFYSQIRGFHLPPSKL--SSLKFEKAVYRVQLSEFSPPGSRV-VMVRVTPAFPNL--- 393
Query: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD---FDLFANESVPDH 440
+++ P+S + R + + +D +D + L S P
Sbjct: 394 -------------QYVLKPSSENVGFKLNARTGLITTTKLMDFHDRAHYQLHIRTS-PGQ 439
Query: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS 500
V I +++ N++ P+F++ Y+ +L EN+ GTSVL V ATD D G G V+Y +
Sbjct: 440 AS-TVVVIDIVDCNNHAPLFNRSSYDGTLDENIPPGTSVLAVTATDRDHGENGYVTYSIA 498
Query: 501 DDPD-RFSLDKDTGLIMLIARLDYELIQR-FTLTIIARDGGG---EETTGRVRINVLDVN 555
FS+D G+I +DYEL++R +T + A D G E + + + ++N
Sbjct: 499 GPKALPFSIDPYLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLN 558
Query: 556 DNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLY 615
DN P F++ G++R++ P ++ + A D D N + Y IVS + YFD++ +
Sbjct: 559 DNQPMFEEVNCTGSIRQDWPVGKSIMTMSAIDVDELQN--LKYEIVSGNEL-EYFDLNHF 615
Query: 616 EGYGVISVSRPLDYEQISNGLIY-LTVMAMDAGN----PPLNST--------VPVT---- 658
GVIS+ RP Y L + A D N LN T VPVT
Sbjct: 616 S--GVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKT 673
Query: 659 ----------------------------IEVFDENDNPPTFSKP-AYFVSVVENIMAGAT 689
+ + N P F + V+E++
Sbjct: 674 GVLTQFTKTILHFIGLQNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTP 733
Query: 690 VLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIVR 747
+ L ATD D + + + +G+ + F I +G +T + LD E + YIL V
Sbjct: 734 LARLAATDPDAG--FNGKLVYVIADGNEEGCFDIELETGLLTVAAPLDYEATNFYILNVT 791
Query: 748 AVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDL 807
D G + TVN+ D NDN P + Y + + E T + + + D D
Sbjct: 792 VYDLGTPQKSSWKLLTVNVK--DWNDNAPRFPPGGYQLTISEDTEVGTTIAELTTKDADS 849
Query: 808 GENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867
+NG + Y++ P + +SL+ TG++ T LDR E+E + V D
Sbjct: 850 EDNGRVRYTLLSPTEKFSLHPLTGELVVT-GHLDR------ESEPRYILKVEARDQPSKG 902
Query: 868 LKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927
+ S + + L D+NDN P +V E +P G + + A D D G G V Y
Sbjct: 903 HQLFSVTDLIITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRY 962
Query: 928 RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTP-TKSSTSTLTIHVL 986
+ G F ++ +G ++ ELD ER A Y L + ASD G P + + + + VL
Sbjct: 963 VLMDG-AHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVL 1021
Query: 987 DVND--ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFS 1044
DVN+ P F V+ V E+ P +V+ + D+D GL+ EL YF+ G FS
Sbjct: 1022 DVNENLHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFS 1081
Query: 1045 VGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQ 1104
+ +++T+ LDRE + Y L + A+D G V + V++ V D NDN P Q
Sbjct: 1082 INQDTGMIQTLAPLDREFASYYWLTVLAVDRGSVPL--SSVTEVYIEVTDANDNPPQMSQ 1139
Query: 1105 SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPR 1164
+ + S+ ED P G S+LQL A D D G++ + I GN+ F IH GLL +
Sbjct: 1140 AVFYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTA-Q 1198
Query: 1165 PLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYS-RLGLRETAG 1223
LDRE H+L V ++ ++S+ RV+V + D+ND P+F+ + ++ RL R +
Sbjct: 1199 QLDRENKDEHILEVTVLDNGEPSLKSTSRVVVGILDVNDNPPIFSHKLFNVRLPERLSPV 1258
Query: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNV 1283
V + A+D D G G V Y I E F ID TG++ + + + ++ +
Sbjct: 1259 SPGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSS--TFTAGEYNILTI 1316
Query: 1284 SATDQAPPFNQGFCSVYITLL---NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSI 1340
ATD P ++I + + F Y ++E + + +
Sbjct: 1317 KATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNHMVGVISVEGR 1376
Query: 1341 DNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDS 1400
L + FN + F I+ TG I + +D + Y LTV DG + +
Sbjct: 1377 PGL----FWFN-ISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDGSRTIAT 1431
Query: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
V +++ + + N + P+F + V +P+D G + V+A D D G + +++++
Sbjct: 1432 QVHIFM-IANINHHRPQF-LETRYEVRVPQDTVPGVELLRVQAIDQDKGKS--LIYTIHG 1487
Query: 1461 GNIAGAFEIVTTNDSIGEVFVARPLD-REELDHYILQVVASDRGTPPRKKDHILQVTILD 1519
G+ + + S G + LD + L V+ D+ P ++ + + + D
Sbjct: 1488 SQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFVWVTIHVED 1547
Query: 1520 INDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMD 1579
N +PP + Y SV + + GT ++QVRA D D G+N+ + Y + +GN + F ++
Sbjct: 1548 GNLHPPRF-TQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEGFFNIN 1606
Query: 1580 RISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHY 1639
+ G I T D+ + + L ED+G+P V + + + +AP+F + Y
Sbjct: 1607 ALLG-IITLAQKLDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEY 1665
Query: 1640 EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699
V + E + + ++ + A+ E VTY + GN F ++ + G+I+ K+LD
Sbjct: 1666 FVEIPES-IPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSGLISTQKKLD 1719
Query: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD-YEGPFEVTEGQ 1758
+E Y L + ++ + V+V++ D NDN P F + + G +++E
Sbjct: 1720 HE-KISSYQLKIRGSNMAGAF-----TDVMVVVDIIDENDNAPMFLKSTFVG--QISEAA 1771
Query: 1759 P--------GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELD 1810
P + A D D N + Y I++ + L F I P G L + E+D
Sbjct: 1772 PLYSMIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVS--EMD 1829
Query: 1811 RETIAFYNLTICARDRGMPPLSS--TMLVGIRVLDINDNDPVLLNLPMNITISENSPVSS 1868
E++ + + D+G P L + V I V D+ND+ P + I
Sbjct: 1830 YESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGM 1889
Query: 1869 FVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRP--LDRERIPEYKLTI 1926
+ V ASD DS N ++I GN + A I+ TG ++V P L R KLTI
Sbjct: 1890 ELLMVRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVLNPAFLGLSR----KLTI 1941
Query: 1927 SVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPIL 1986
D +D L+ I L+ D F + Y A V EN L +L
Sbjct: 1942 RASDG------LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGA--- 1992
Query: 1987 ALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDI 2046
+ ++Y LL + +F + S GV+ R GV DRE EL + D
Sbjct: 1993 ---QGNHLNDTLSYFLLNG-TDMFHMVQSAGVLQTR-GVAFDRE--QQDTHELAVEVRDN 2045
Query: 2047 GLLNSTAHLL--ITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGEL 2104
A L ++I D NDN P F + + PG + QV+ATDED G NG +
Sbjct: 2046 RTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAV 2105
Query: 2105 VYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILI 2164
Y A F I G I + D + Y L V+A D GT L V + +
Sbjct: 2106 TYEF-AEDYTYFRIDPYLGDISL-KKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTV 2163
Query: 2165 DDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLV 2224
N S P F +P V V E+ T I + A + +L Y+IV + + L+
Sbjct: 2164 R--NKSNPLFQSPYYKVRVPENITLYTPILHTQARSPE-GLRLIYNIV------EEEPLM 2214
Query: 2225 PNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVL 2284
F + TG + V P++ E + T+ D A S A + V V
Sbjct: 2215 -----LFTTDFKTGVLTVTGPLDYESKTKHVFTVRATDTALG------SFSEATVEVLVE 2263
Query: 2285 DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLD--LVPPG 2342
DVNDN P F Y I EG T +I + A D D G N V+Y +++
Sbjct: 2264 DVNDNPPTFSQL---VYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSK 2320
Query: 2343 YVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIF 2402
+ Q+ + S G++ + +DYE + VRA D G PP E V + + DINDN P F
Sbjct: 2321 FFQI-NGSTGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEF 2379
Query: 2403 DQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVL 2460
QP Y+ V E G ++L V A D DS + + +EY + G+ + F IN ++G I +
Sbjct: 2380 RQPQYEANVSELATCGHLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMF 2439
Query: 2461 SSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYE 2520
+ + Y L A D +V V I + N P+F + + + E
Sbjct: 2440 NLCKKHLDSSYNLRVGASDGV-------FRATVPVYINTTNANKYSPEFQQHLYEAELAE 2492
Query: 2521 NEPAGTSVITMMATDQDEGPNGELTYSLEGP-GVEAFHVDMDSGLVTTQ---RPLQSYEK 2576
N GT VI ++A D+D GP G + Y++ E F ++ + + T Q R +
Sbjct: 2493 NAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERV 2552
Query: 2577 FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVY 2636
++ V+A DGG + T ++ + D NDN P F + + I+ + S V +V
Sbjct: 2553 IAIKVMARDGGGRVAFCTVKII--LTDENDNPPQF--KASEYTVSIQSNVSKDSPVIQVL 2608
Query: 2637 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDL 2696
A D DEG N V YS +D I+P++G+++ L + A D
Sbjct: 2609 AYDADEGQNADVTYSVNPEDLVKD--VIEINPVTGVVKVKDSLVGLENQTLDFFIKAQD- 2665
Query: 2697 GQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDA 2756
G P + ++ P+++ + P V PK S + PE P G+ +G V
Sbjct: 2666 GGPPHWNSLVPVRLQV------VPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQ 2719
Query: 2757 DEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPR 2815
D ++V N++ F L PD G + V + +D E ++ V A ++
Sbjct: 2720 DPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQIDVMAHCLQN----- 2774
Query: 2816 GPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADI 2875
D+V +L V + + D+ND P F Y A + + VG+ +IQV A+D D
Sbjct: 2775 -----TDVV---SLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDT 2826
Query: 2876 GNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRT 2916
G + V Y R A+ +V ++F + S G + T
Sbjct: 2827 GRDGQVSY--------RLSADPGSNVHELFAIDSESGWITT 2859
Score = 734 bits (1895), Expect = 0.0
Identities = 806/2967 (27%), Positives = 1300/2967 (43%), Gaps = 297/2967 (10%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEP 82
N P F +D L E+ P G+SV + A D D N + + ++G +A F +++P
Sbjct: 453 NHAPLFNRSSYDGTL--DENIPPGTSVLAVTATDRDHGENGYVTYSIAGPKALPF-SIDP 509
Query: 83 DTGVVWLRQPLDRE-TKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPY 137
G++ +P+D E K +T SD R+ + +Q+ ++NDN P F
Sbjct: 510 YLGIISTSKPMDYELMKRIYTFRVRASDWGSPFRREKEVSIFLQLRNLNDNQPMFEEVNC 569
Query: 138 SVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIR---ELD 194
+ I ++ PVG I ++A D D ++F ++ G++++ R L
Sbjct: 570 TGSIRQDWPVGKSIMTMSAIDVDELQNLKYEIVSGNELEYFDLNHFSGVISLKRPFINLT 629
Query: 195 YETTQAYQLTVNATDQ-------------------------DKTRPLSTLANLAIIITDV 229
+Y L + A+D DKT L+ + +
Sbjct: 630 AGQPTSYSLKITASDGKNYASPTTLNITVVKDPHFEVPVTCDKTGVLTQFTKTILHFIGL 689
Query: 230 QDM---DPIFINL----------------PYSTNIYEHSPPGTTVRIITAIDQDKGRPRG 270
Q+ D F +L P S ++ E P T + + A D D G
Sbjct: 690 QNQESSDEEFTSLSTYQINHYTPQFEDHFPQSIDVLESVPINTPLARLAATDPDAGFNGK 749
Query: 271 IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATV 330
+ Y I GN F ++ +G+LT+ LD E ++ +IL V +L + S +
Sbjct: 750 LVYVIADGNEEGCFDIELETGLLTVAAPLDYE---ATNFYILNVTVYDLGTPQKSSWKLL 806
Query: 331 TTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYL 390
T + V D NDNAP F Y + I+E +VG + ++ KD + N Y
Sbjct: 807 T----VNVKDWNDNAPRFPPGGYQLTISEDTEVGTTI---AELTTKDADSEDNGRVR-YT 858
Query: 391 VGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE---------SVPDHV 441
+ + + F + P + + + V LD E+ RY + A + SV D +
Sbjct: 859 LLSPTEKFSLHPLTGE------LVVTGHLDRESEPRYILKVEARDQPSKGHQLFSVTDLI 912
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD 501
ITL + NDN P + + E++ GT + + A+D D G GEV Y D
Sbjct: 913 ------ITLEDVNDNSPQCITEHNRLKVPEDLPPGTVLTFLDASDPDLGPAGEVRYVLMD 966
Query: 502 DP-DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG---GEETTGRVRINVLDVNDN 557
F +D TG ++L LD+E + L++ A DGG T V + VLDVN+N
Sbjct: 967 GAHGTFRVDLMTGALILERELDFERRAGYNLSLWASDGGRPLARRTLCHVEVIVLDVNEN 1026
Query: 558 V--PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLY 615
+ P F + G ++EN PS TQ++ + A D+DS + ++ Y + + + ++ S+
Sbjct: 1027 LHPPHFASFVHQGQVQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAF---SIN 1083
Query: 616 EGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPA 675
+ G+I PLD E S +LTV+A+D G+ PL+S V IEV D NDNPP S+
Sbjct: 1084 QDTGMIQTLAPLDREFAS--YYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAV 1141
Query: 676 YFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLD 735
++ S+ E+ G +VL L+A D D S + I S F I+ +G ++T LD
Sbjct: 1142 FYPSIQEDAPVGTSVLQLDAWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLD 1201
Query: 736 RETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDS 795
RE K E+IL V +D G + T V I LD+NDN P + + + L E P S
Sbjct: 1202 RENKDEHILEVTVLDNGEPSLKSTSRVVVGI--LDVNDNPPIFSHKLFNVRLPERLSPVS 1259
Query: 796 --DVTTVVAVDPDLGENGTLVYSIQPPN-KFYSLNSTTGKIRTTHAMLDRENPDPHEAEL 852
V +VA D D G NG + YSI+ + + +S++ TG + ++ E
Sbjct: 1260 PGPVYRLVASDLDEGLNGRVTYSIEDSDEEAFSIDLVTGVVSSSSTFTAGE--------- 1310
Query: 853 MRKIVVSVTDCGRPPLKATSSATV-FVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQ 911
+ + TD G+PPL A+ + ++ + F + V+E P +
Sbjct: 1311 YNILTIKATDSGQPPLSASVRLHIEWIPWPRPSSIPLAFDETYYSFTVMETDP----VNH 1366
Query: 912 VVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAG 971
+V + EG GL + + G MDF I ++G +V LD R + Y L V +D
Sbjct: 1367 MVGVISVEGRPGLFWFNISGGDKDMDFDIEKTTGSIVIARPLDTRRRSNYNLTVEVTDG- 1425
Query: 972 TPTKSSTSTLTIHVL---DVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNA 1028
S T +H+ ++N P F Y V V +D ++ + D D G
Sbjct: 1426 ----SRTIATQVHIFMIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKG--K 1479
Query: 1029 ELSYFITGGNVDGKFSVGYRD---AVVRTVVGLDRET-TAAYMLILEAIDNGPVGKRHTG 1084
L Y I G G S+ D V+ TV LD + + + L + D KR+
Sbjct: 1480 SLIYTIHGSQDPGSASLFQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQEIPIKRNFV 1539
Query: 1085 TATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG 1144
T+ V D N + P F Q YEASVP+ I G +LQ++A DAD G V Y +L G
Sbjct: 1540 WVTIHVE--DGNLHPPRFTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKG 1597
Query: 1145 NHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDE 1204
N F I+ G++ + LD+ ++ H L V+A + VI++V +
Sbjct: 1598 NSEGFFNINALLGIITLAQK-LDQANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRS 1656
Query: 1205 APVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTG 1263
AP+F++ +Y + + E+ +G+ +++V A V Y + G +G F ++ +G
Sbjct: 1657 APIFSKSEYF-VEIPESIPVGSPILLVSAMSPSE-----VTYELREGNKDGVFSMNSYSG 1710
Query: 1264 LIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASY----- 1318
LI T LD+E +SY + + ++ A F V + +++E D A F +++
Sbjct: 1711 LISTQKKLDHEKISSYQLKIRGSNMAGAFTD--VMVVVDIIDENDNAPMFLKSTFVGQIS 1768
Query: 1319 EAAILENLALGTE----IVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
EAA L ++ + ++ + + + Y+ +A FKID G +T+
Sbjct: 1769 EAAPLYSMIMDKNNNPFVIHASDSDKEANSLLVYKI---LEPEALKFFKIDPSMGTLTIV 1825
Query: 1375 GLVDREKGDFYTLTVVADDGGPKV---DSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
+D E + V D G V +V I V D ND+ PRF V+I
Sbjct: 1826 SEMDYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFS-EQIYEVAIVGP 1884
Query: 1432 CPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARP----LDR 1487
G + V+A D D+ +V +S+ +GN A E VT + G + V P L R
Sbjct: 1885 IHPGMELLMVRASDEDS----EVNYSIKTGN---ADEAVTIHPVTGSISVLNPAFLGLSR 1937
Query: 1488 EELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
+ L + ASD + ++++++ + D + Y +V EN+ A+
Sbjct: 1938 K------LTIRASD---GLYQDTALVKISLTQVLDKSLQFDQDV-YWAAVKENLQDRKAL 1987
Query: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVE 1607
V + A +N LSY++ G DM F M + +G + TR DRE+Q + L V
Sbjct: 1988 VILGAQGNH--LNDTLSYFLLNGT-DM-FHMVQSAGVLQTRGVAFDREQQDTHELAVEVR 2043
Query: 1608 DEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPN 1667
D TP A V V+I D NDN P F+ Y ++ +G + L + A D D G N
Sbjct: 2044 DNRTPQRVAQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEP-GDVLFQVSATDEDLGTN 2102
Query: 1668 GTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTST 1727
G VTY FRID ++G I+ K DY+ + +Y L V A D + L S
Sbjct: 2103 GAVTYEFAED--YTYFRIDPYLGDISLKKPFDYQ-ALNKYHLKVIARDGG---TPSLQSE 2156
Query: 1728 TTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNG-QVEYSIMDG 1786
VLV V N + P F + P+ ++T + H + P G ++ Y+I++
Sbjct: 2157 EEVLVTVR--NKSNPLF----QSPYYKVRVPENITLYTPILHTQARSPEGLRLIYNIVEE 2210
Query: 1787 DPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDIND 1846
+PL F GVL V LD E+ + T+ A D + S V + V D+ND
Sbjct: 2211 EPLMLFTTDFKTGVLTVTG--PLDYESKTKHVFTVRATDTALGSFSEA-TVEVLVEDVND 2267
Query: 1847 NDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRE--RAFFINAT 1904
N P L +ISE P + V +LASD DSG N +++ I + + F IN +
Sbjct: 2268 NPPTFSQLVYTTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGS 2327
Query: 1905 TGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTY 1964
TG ++ + LD E + + + D + P L+++ +SD NDN P F + Y
Sbjct: 2328 TGEMSTVQELDYEAQQHFHVKVRAMDKGDPPLTGE---TLVVVNVSDINDNPPEFRQPQY 2384
Query: 1965 QAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRS 2023
+A V E + G L + A+D D + + Y +L G Q F INSS+G++++ +
Sbjct: 2385 EANVSELATCGH----LVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSGIISMFN 2440
Query: 2024 GVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCP 2083
+ + S L + A D G+ +T + I + N P F L EN
Sbjct: 2441 --LCKKHLDSS--YNLRVGASD-GVFRATVPVYINTTNANKYSPEFQQHLYEAELAENAM 2495
Query: 2084 PGFSVLQVTATDEDSGLNGELVYR-IEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRL 2142
G V+ + A D+DSG G + Y I A ++F I+ + + + + +
Sbjct: 2496 VGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQIATLQKLDRENSTERVIAI 2555
Query: 2143 TVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD 2202
V+A D G T V I++ D ND+ P+F TVS+ + + + + A D D
Sbjct: 2556 KVMARDGGGRVAFCT--VKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDAD 2613
Query: 2203 LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVID 2262
E + + + LV +D +N TG V VK LV TL
Sbjct: 2614 -----EGQNADVTYSVNPEDLV---KDVIEINPVTGVVKVKD----SLVGLENQTLDFFI 2661
Query: 2263 NASD--LPERSVSVPNAKLTVNVLDVNDNTPQF-KPFGITYYMERILEGATPGTTLIAVA 2319
A D P + VP + + V+ + P+F +P E + EG+ G + AVA
Sbjct: 2662 KAQDGGPPHWNSLVP---VRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIG-IVKAVA 2717
Query: 2320 AVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGS 2379
A DP + LV T + G L D G + + +D+E V A +
Sbjct: 2718 AQDP--VIYSLVRGTTPESNKDGVFSL-DPDTGVIKVRKPMDHESTKLYQIDVMAHCLQN 2774
Query: 2380 PPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEY 2439
+ + V +++ D+NDN P+F+ Y+ + E++PVGT ++ VTA D D+G + Y
Sbjct: 2775 TDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSY 2834
Query: 2440 SL-----GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQ 2494
L + FAI+ +G I L LD E Y +A D+ + + +
Sbjct: 2835 RLSADPGSNVHELFAIDSESGWITTLQELDCETCQTYHFHVVAYDHGQTI---QLSSQAL 2891
Query: 2495 VVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD-EGPNGELT-YSLEGPG 2552
V + + D ND P+F+ ++ SV EN G V T+ D D N ++T Y EG
Sbjct: 2892 VQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDP 2951
Query: 2553 VEAFHVDM--DSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNR 2608
+ F + D +++++ L + K+ L V A+DG + + + V+DVNDN
Sbjct: 2952 LGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDG---KFQASVTVEIFVLDVNDN- 3007
Query: 2609 PVFVRPPNGTILH---IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFI 2665
P +L+ + E++ + +V ATD D N + YS + F
Sbjct: 3008 ----SPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAHE----FK 3059
Query: 2666 IDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRP 2725
+DP +G + T LDRE + V++L+ A+D G + + +ED++DN P F
Sbjct: 3060 LDPHTGELTTLTALDRERKDVFNLVAKATDGG---GRSCQADITLHVEDVNDNAPRFF-- 3114
Query: 2726 PKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQ-PDGC 2784
P + + V +++ T V V A D D+G NA V Y + + E +F + G
Sbjct: 3115 ----PSHCAVAVFDNTTVKTPVA-VVFARDPDQGANAQVVYSL-PDSAEGHFSIDATTGV 3168
Query: 2785 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPP 2844
+ + + L +A V+AS + P P TL V V + + D P
Sbjct: 3169 IRLEKPLQVRPQAPLELTVRASDLGT------PIPL------STLGTVTVSVVGLEDYLP 3216
Query: 2845 RFTKAEYTAGVATDAKVGSELIQVLAL 2871
F E++ V DA G+E++Q+ L
Sbjct: 3217 VFLNTEHSVQVPEDAPPGTEVLQLATL 3243
Score = 680 bits (1755), Expect = 0.0
Identities = 743/2725 (27%), Positives = 1200/2725 (44%), Gaps = 230/2725 (8%)
Query: 42 ISEDTPVGSSVTQLLAQDMDND---PLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ E++P G+ V + AQD D+ L + + F++ DTG++ PLDRE
Sbjct: 1041 VQENSPSGTQVIVVAAQDDDSGLDGELQYFLRAGTGLAAFSINQDTGMIQTLAPLDREFA 1100
Query: 99 SEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVN 155
S + + D V +V I+V D NDN P + I E+ PVGT + ++
Sbjct: 1101 SYYWLTVLAVDRGSVPLSSVTEVYIEVTDANDNPPQMSQAVFYPSIQEDAPVGTSVLQLD 1160
Query: 156 ATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKT 213
A DPD + G + ++ + FF I G+++ ++LD E + L V D +
Sbjct: 1161 AWDPDSSSKGKLTFNITSGNYMGFFMIHPVTGLLSTAQQLDRENKDEHILEVTVLDNGEP 1220
Query: 214 RPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH-SP--PGTTVRIITAIDQDKGRPRG 270
ST + + + I DV D PIF + ++ + E SP PG R++ A D D+G
Sbjct: 1221 SLKST-SRVVVGILDVNDNPPIFSHKLFNVRLPERLSPVSPGPVYRLV-ASDLDEGLNGR 1278
Query: 271 IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATV 330
+ Y+I + + F++D ++GV++ + Y+ ILT+K T+ + P A+V
Sbjct: 1279 VTYSIEDSDEEA-FSIDLVTGVVSSSSTFTAGE--YN---ILTIKATD--SGQPPLSASV 1330
Query: 331 TTTFNILVIDINDNAP-EFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVY 389
+ + P F+ + YS + E V + V+ + GL F +
Sbjct: 1331 RLHIEWIPWPRPSSIPLAFDETYYSFTVMETDPVNH----MVGVISVEGRPGL-FWFNIS 1385
Query: 390 LVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKIT 449
G+ F I T+ I +A PLD T R +++L + +V I
Sbjct: 1386 -GGDKDMDFDIEKTTGS------IVIARPLD--TRRRSNYNLTVEVTDGSRTIATQVHIF 1436
Query: 450 LI-NENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--- 505
+I N N +RP F + Y + + ++ G +L V A D D G + S DP
Sbjct: 1437 MIANINHHRPQFLETRYEVRVPQDTVPGVELLRVQAIDQDKGKSLIYTIHGSQDPGSASL 1496
Query: 506 FSLDKDTGLIMLIARLDYEL-IQRFTLTIIARDGGGEETTGR----VRINVLDVNDNVPT 560
F LD +G+++ + +LD + TLT++ RD E R V I+V D N + P
Sbjct: 1497 FQLDPSSGVLVTVGKLDLGSGPSQHTLTVMVRDQ--EIPIKRNFVWVTIHVEDGNLHPPR 1554
Query: 561 FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
F + Y ++ + T+L+++RA D D N ++ YS++ ++ G +F+I+ G+
Sbjct: 1555 FTQLHYEASVPDTIAPGTELLQVRAMDADRGVNAEVHYSLLKGNSEG-FFNINAL--LGI 1611
Query: 621 ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 680
I++++ LD Q ++ LTV A D G+P + V I V+ + + P FSK YFV +
Sbjct: 1612 ITLAQKLD--QANHAPHTLTVKAEDQGSPQWHDLATVIIHVYPSDRSAPIFSKSEYFVEI 1669
Query: 681 VENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ--FRINARSGEITTTSLLDRE 737
E+I G+ +L ++A + Y L EG+ F +N+ SG I+T LD E
Sbjct: 1670 PESIPVGSPILLVSAMS--------PSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHE 1721
Query: 738 TKSEYILIVRAVDGGVGHNQKTGIATVNIT--LLDINDNHPTWKDAPYYINLVEMTP--- 792
S Y L +R G N V + ++D NDN P + + + + E P
Sbjct: 1722 KISSYQLKIR------GSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYS 1775
Query: 793 ----PDSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPD 846
+++ + A D D N LVY I P KF+ ++ + G + M
Sbjct: 1776 MIMDKNNNPFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEM------- 1828
Query: 847 PHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAG 906
+E+ + V V D G P L A A V +++ D+ND+ P F + ++ I G
Sbjct: 1829 DYESMPSFQFCVYVHDQGSPVLFAPRPAQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPG 1888
Query: 907 VSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGV--VVTTTELDRERIAEYQLR 964
+ + V A D D +N Y + G I+ +G V+ L R +L
Sbjct: 1889 MELLMVRASDEDSEVN----YSIKTGNADEAVTIHPVTGSISVLNPAFLGLSR----KLT 1940
Query: 965 VVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDV 1024
+ ASD T+ + I + V D++ F VY +V E++ +V L N
Sbjct: 1941 IRASDG---LYQDTALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKALVILGAQGNH- 1996
Query: 1025 GLNAELSYFITGGNVDGKFSVGYRDAVVRTV-VGLDRETTAAYMLILEAIDNGPVGKRHT 1083
LN LSYF+ G F + V++T V DRE + L +E DN +
Sbjct: 1997 -LNDTLSYFLLNGT--DMFHMVQSAGVLQTRGVAFDREQQDTHELAVEVRDNRT--PQRV 2051
Query: 1084 GTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILH 1143
V V++ DVNDN P F Y + + G + Q+ ATD D G G V Y
Sbjct: 2052 AQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAE 2111
Query: 1144 GNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDIND 1203
FRI G + +P D + + + L V A + ++S V+V V N
Sbjct: 2112 DY--TYFRIDPYLGDISL-KKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVR--NK 2166
Query: 1204 EAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK-FEIDEST 1262
P+F Q Y ++ + E + T ++ QA S +G + Y I+ F D T
Sbjct: 2167 SNPLF-QSPYYKVRVPENITLYTPILHTQAR---SPEGLRLIYNIVEEEPLMLFTTDFKT 2222
Query: 1263 GLIITVNYLDYETKTSYMMNVSATDQA-PPFNQGFCSVYITLLNELDEAVQFSNASYEAA 1321
G++ LDYE+KT ++ V ATD A F++ V + +N D FS Y +
Sbjct: 2223 GVLTVTGPLDYESKTKHVFTVRATDTALGSFSEATVEVLVEDVN--DNPPTFSQLVYTTS 2280
Query: 1322 ILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVI-TVQGLVD 1378
I E L T ++++ A D+ ++Y+ S +K F+I+ TG + TVQ L
Sbjct: 2281 ISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSK-FFQINGSTGEMSTVQELDY 2339
Query: 1379 REKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRV 1438
+ F+ D G P + V + V D NDN P F A ++ E G V
Sbjct: 2340 EAQQHFHVKVRAMDKGDPPLTGETLVVVNVSDINDNPPEFRQPQYEA-NVSELATCGHLV 2398
Query: 1439 ATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVV 1498
V+A DPD+ ++ + + SGN F I N S G + + + Y L+V
Sbjct: 2399 LKVQAIDPDSRDTSRLEYLILSGNQDRHFFI---NSSSGIISMFNLCKKHLDSSYNLRVG 2455
Query: 1499 ASD---RGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDR 1555
ASD R T P + + + N P + Y + EN GT V+ + A D+
Sbjct: 2456 ASDGVFRATVP------VYINTTNANKYSPEFQQHL-YEAELAENAMVGTKVIDLLAIDK 2508
Query: 1556 DIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLS 1615
D G + Y I F ++ +G+IAT DRE + + V
Sbjct: 2509 DSGPYGTIDYTIINKLASEKFSINP-NGQIATLQKL-DRENSTERVIAIKVMARDGGGRV 2566
Query: 1616 ATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIV 1675
A V + + DENDN P F+ Y V + ++ +I + A D DEG N VTY++
Sbjct: 2567 AFCTVKIILTDENDNPPQFKASEYTVSIQSNVSK-DSPVIQVLAYDADEGQNADVTYSVN 2625
Query: 1676 AGNIV-NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNV 1734
++V + I+ GV+ L + + + A D P S V + V
Sbjct: 2626 PEDLVKDVIEINPVTGVVKVKDSL-VGLENQTLDFFIKAQDGGP---PHWNSLVPVRLQV 2681
Query: 1735 NDINDNVPTFPRD---YEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDG----- 1786
++P F + P ++ EG V A D V YS++ G
Sbjct: 2682 VPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQD-------PVIYSLVRGTTPES 2734
Query: 1787 DPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDIND 1846
+ G F + P GV++VRK +D E+ Y + + A + S + V I+V D+ND
Sbjct: 2735 NKDGVFSLDPDTGVIKVRKP--MDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDVND 2792
Query: 1847 NDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITA---GNRERAFFINA 1903
N PV P ++EN PV + V V A D D+G + ++++ ++A N F I++
Sbjct: 2793 NRPVFEADPYKAVLTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFAIDS 2852
Query: 1904 TTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKST 1963
+G +T + LD E Y + D+ + +++ + L+ + ++DENDN P F
Sbjct: 2853 ESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQA--LVQVSITDENDNAPRFASEE 2910
Query: 1964 YQAEVMENSPAGTPLTVLNGPILALDAD--QDIYAVVTYQLLGAQSGLFDINSSTGVVTV 2021
Y+ V+ENS G + L LDAD + V Y G G F I+ +
Sbjct: 2911 YRGSVVENSEPGELVATLK----TLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRI 2966
Query: 2022 RSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLEN 2081
S +DRE + +L + A D G ++ + I +LD NDN P S T + E+
Sbjct: 2967 SSRKTLDREHTAKYLLRVT--ASD-GKFQASVTVEIFVLDVNDNSPQCSQLLYTGKVHED 3023
Query: 2082 CPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYR 2141
PG +L+V+ATD D+ N ++ Y + F + TG + A +DRE ++ +
Sbjct: 3024 VFPGHFILKVSATDLDTDTNAQITYSLHGPGAHEFKLDPHTGELTTLTA-LDRERKDVFN 3082
Query: 2142 LTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDH 2201
L ATD G S A +T+ ++D+ND+ P F V+V ++ T +A + A D
Sbjct: 3083 LVAKATDGGG--RSCQADITLHVEDVNDNAPRFFPSHCAVAVFDNTTVKTPVAVVFARDP 3140
Query: 2202 D--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLS 2259
D N ++ Y L + E F+++ TG + ++ P+ A E+T+
Sbjct: 3141 DQGANAQVVYS------------LPDSAEGHFSIDATTGVIRLEKPLQVRPQAPLELTVR 3188
Query: 2260 VIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVA 2319
D + +P ++ +TV+V+ + D P F T + ++ E A PGT ++ +A
Sbjct: 3189 ASDLGTPIPLSTLGT----VTVSVVGLEDYLPVFLN---TEHSVQVPEDAPPGTEVLQLA 3241
Query: 2320 AVD-PDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNG 2378
+ P G Y ++ G +L D+ G + N ++D+E ++ S
Sbjct: 3242 TLTRPGAEKTG---YRVVSGNEQGRFRL-DARTGILYVNASLDFETSPKYFLSIECSRKS 3297
Query: 2379 SPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIE 2438
S + V + I D+N++ P F Q Y V E+ VG +ILTV+ATD D + I
Sbjct: 3298 SSSLSDVTTVMVNITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDIT 3357
Query: 2439 YSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVV 2496
YSL G+ F I+P G++ V +LDRE+ Y L A D+ +
Sbjct: 3358 YSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKLRATDS----GQPPLHEDTDIA 3413
Query: 2497 IQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL---EGPGV 2553
IQV DVND P+F + +ST+V EN P G+ V+ ++ +D D NG YS +G
Sbjct: 3414 IQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSPENGP-PYSFRITKGNNG 3472
Query: 2554 EAFHVDMDSGLVTTQ-RPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFV 2612
AF V D LVT + ++ E + L + A+D G PPL T + V V + + P +
Sbjct: 3473 SAFRVTPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPLSSLTSVRVHVTEQSHYAPSAL 3532
Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFL--KTAGNRDWEFFIIDPIS 2670
P + + E+ V +++ATD+D + YS +T G F +
Sbjct: 3533 --PLEIFITVGEDEFQGGMVGKIHATDRDP--QDTLTYSLAEEETLGRH----FSVGAPD 3584
Query: 2671 GLIQTAQRLDRESQAVYSLILVASD 2695
G I AQ L R YS + SD
Sbjct: 3585 GKIIAAQGLPR---GHYSFNVTVSD 3606
Score = 607 bits (1565), Expect = e-173
Identities = 561/1939 (28%), Positives = 870/1939 (44%), Gaps = 144/1939 (7%)
Query: 39 YLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
++ I E PVGS + LL M + + + F++ +G++ ++ LD E
Sbjct: 1666 FVEIPESIPVGSPI--LLVSAMSPSEVTYELREGNKDGVFSMNSYSGLISTQKKLDHEKI 1723
Query: 99 SEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI------ 151
S + ++ S+ G T V + + D NDNAP F + +I E P+ + I
Sbjct: 1724 SSYQLKIRGSNMAGAFTDVMVVVDIIDENDNAPMFLKSTFVGQISEAAPLYSMIMDKNNN 1783
Query: 152 -FIVNATDPDLGAGGSVLYSFQPPS--QFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
F+++A+D D A ++Y P +FF ID + G +T++ E+DYE+ ++Q V
Sbjct: 1784 PFVIHASDSDKEANSLLVYKILEPEALKFFKIDPSMGTLTIVSEMDYESMPSFQFCVYVH 1843
Query: 209 DQDKT-----RPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQ 263
DQ RP A + I + DV D P F Y I PG + ++ A D+
Sbjct: 1844 DQGSPVLFAPRP----AQVIIHVRDVNDSPPRFSEQIYEVAIVGPIHPGMELLMVRASDE 1899
Query: 264 DKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDR 323
D + Y+I +GN + + ++G +++ NP + L+ K T D
Sbjct: 1900 DSE----VNYSIKTGNADEAVTIHPVTGSISVL------NPAFLG---LSRKLTIRASDG 1946
Query: 324 TPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLN 383
D T I + + D + +F+ Y A+ E Q AL V+ + LN
Sbjct: 1947 LYQD---TALVKISLTQVLDKSLQFDQDVYWAAVKENLQDRKAL-----VILGAQGNHLN 1998
Query: 384 SMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHV 441
+L+ G + H + S +Q + + D E D ++ + ++ P V
Sbjct: 1999 DTLSYFLLNGTDMFHMVQSAGVLQTRG-------VAFDREQQDTHELAVEVRDNRTPQRV 2051
Query: 442 GYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSD 501
V++++ + NDN P F Y + + G + V ATD D GT G V+Y F++
Sbjct: 2052 AQGLVRVSIEDVNDNPPKFKHLPYYTIIQDGTEPGDVLFQVSATDEDLGTNGAVTYEFAE 2111
Query: 502 DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTF 561
D F +D G I L DY+ + ++ L +IARDGG + V N + P F
Sbjct: 2112 DYTYFRIDPYLGDISLKKPFDYQALNKYHLKVIARDGGTPSLQSEEEVLVTVRNKSNPLF 2171
Query: 562 QKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS---AFGSYFDISLYEGY 618
Q Y + EN +T + T SP ++ Y+IV F + F
Sbjct: 2172 QSPYYKVRVPEN---ITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKT------ 2222
Query: 619 GVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVF--DENDNPPTFSKPAY 676
GV++V+ PLDYE + + TV A D L S T+EV D NDNPPTFS+ Y
Sbjct: 2223 GVLTVTGPLDYESKTKHV--FTVRATDTA---LGSFSEATVEVLVEDVNDNPPTFSQLVY 2277
Query: 677 FVSVVENIMAGATVLFLNATDLD--RSREYGQESIIYSLEGSTQFRINARSGEITTTSLL 734
S+ E + A V+ L A+D D R+R+ + + + S F+IN +GE++T L
Sbjct: 2278 TTSISEGLPAQTPVIQLLASDQDSGRNRDVSYQIVEDGSDVSKFFQINGSTGEMSTVQEL 2337
Query: 735 DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD 794
D E + + + VRA+D G TG V + + DINDN P ++ Y N+ E+
Sbjct: 2338 DYEAQQHFHVKVRAMD--KGDPPLTGETLVVVNVSDINDNPPEFRQPQYEANVSELATCG 2395
Query: 795 SDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAEL 852
V V A+DPD + L Y I N + + +NS++G ++ N +
Sbjct: 2396 HLVLKVQAIDPDSRDTSRLEYLILSGNQDRHFFINSSSG-------IISMFNLCKKHLDS 2448
Query: 853 MRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQV 912
+ V +D +AT V++N + N P FQ + AE+ E G + +
Sbjct: 2449 SYNLRVGASD---GVFRAT--VPVYINTTNANKYSPEFQQHLYEAELAENAMVGTKVIDL 2503
Query: 913 VAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAE--YQLRVVASDA 970
+AID D G G + Y + + F IN +G + T +LDRE E ++V+A D
Sbjct: 2504 LAIDKDSGPYGTIDYTIINKLASEKFSIN-PNGQIATLQKLDRENSTERVIAIKVMARDG 2562
Query: 971 GTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAEL 1030
G + + T+ I + D ND P F + Y VS+ +V ++ V+ + D D G NA++
Sbjct: 2563 G--GRVAFCTVKIILTDENDNPPQFKASEYTVSIQSNVSKDSPVIQVLAYDADEGQNADV 2620
Query: 1031 SYFITGGN-VDGKFSVGYRDAVVR---TVVGLDRETTAAYMLILEAIDNGPVGKRHTGTA 1086
+Y + + V + VV+ ++VGL+ +T + ++A D GP
Sbjct: 2621 TYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQTLDFF---IKAQDGGP--PHWNSLV 2675
Query: 1087 TVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHG-- 1144
V + V+ + P F + Y S PED+PEG I +KA A + V Y ++ G
Sbjct: 2676 PVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVKAVAAQD----PVIYSLVRGTT 2731
Query: 1145 ---NHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDI 1201
N F + G++ + +P+D E + + V A+ + S V V + V D+
Sbjct: 2732 PESNKDGVFSLDPDTGVI-KVRKPMDHESTKLYQIDVMAHCLQNTDVVSLVSVNIQVGDV 2790
Query: 1202 NDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL----SGAEGKFE 1257
ND PVF Y + L E +GTSVI V A D+D+G G V+YR+ S F
Sbjct: 2791 NDNRPVFEADPYKAV-LTENMPVGTSVIQVTAIDKDTGRDGQVSYRLSADPGSNVHELFA 2849
Query: 1258 IDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFN-QGFCSVYITLLNELDEAVQFSNA 1316
ID +G I T+ LD ET +Y +V A D V +++ +E D A +F++
Sbjct: 2850 IDSESGWITTLQELDCETCQTYHFHVVAYDHGQTIQLSSQALVQVSITDENDNAPRFASE 2909
Query: 1317 SYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGV--ITVQ 1374
Y +++EN G + ++ D Q T F I + I+ +
Sbjct: 2910 EYRGSVVENSEPGELVATLKTLDADISEQNRQVTCYITEGDPLGQFGISQVGDEWRISSR 2969
Query: 1375 GLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPV 1434
+DRE Y L V A DG K ++V V I VLD NDNSP+ + + ED
Sbjct: 2970 KTLDREHTAKYLLRVTASDG--KFQASVTVEIFVLDVNDNSPQCSQLLYTG-KVHEDVFP 3026
Query: 1435 GQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYI 1494
G + V A D D +N Q+ +SL GA E + GE+ LDRE D +
Sbjct: 3027 GHFILKVSATDLDTDTNAQITYSLHG---PGAHEF-KLDPHTGELTTLTALDRERKDVFN 3082
Query: 1495 LQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATD 1554
L A+D G + D L V D+NDN P P V+V +N T V V A D
Sbjct: 3083 LVAKATDGGGRSCQADITLHVE--DVNDNAPRF-FPSHCAVAVFDNTTVKTPVAVVFARD 3139
Query: 1555 RDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTP-T 1613
D G N+ + Y + + + + F +D +G I P Q+ L D GTP
Sbjct: 3140 PDQGANAQVVYSLPD-SAEGHFSIDATTGVIRLE-KPLQVRPQAPLELTVRASDLGTPIP 3197
Query: 1614 LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYA 1673
LS V V++V D P+F + V + P+ +Q L Y
Sbjct: 3198 LSTLGTVTVSVVGLEDYLPVFLNTEHSV---QVPEDAPPGTEVLQLATLTRPGAEKTGYR 3254
Query: 1674 IVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVN 1733
+V+GN FR+D G++ LD+E S +Y L + + + S L+ TTV+VN
Sbjct: 3255 VVSGNEQGRFRLDARTGILYVNASLDFETS-PKYFLSIECSRKS---SSSLSDVTTVMVN 3310
Query: 1734 VNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFV 1793
+ D+N++ P FP+D + G + T A D D N + YS++ G+ LG F
Sbjct: 3311 ITDVNEHRPQFPQDPYSTRVLENALVGDVILTVSATDEDGPLNSDITYSLIGGNQLGHFT 3370
Query: 1794 ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLN 1853
I P +G L+V K LDRE + Y+L + A D G PPL + I+V D+NDN P
Sbjct: 3371 IHPKKGELQVAK--ALDREQASSYSLKLRATDSGQPPLHEDTDIAIQVADVNDNPPRFFQ 3428
Query: 1854 LPMNITISENSPVSSFVAHVLASDADSGCNA-RLTFNITAGNRERAFFINATTGIVTVNR 1912
L + T+ ENSP+ S V ++ SD DS N +F IT GN AF + +VT
Sbjct: 3429 LNYSTTVQENSPIGSKVLQLILSDPDSPENGPPYSFRITKGNNGSAFRVTPDGWLVTA-E 3487
Query: 1913 PLDRERIPEYKLTISVKDN 1931
L R Y+L I D+
Sbjct: 3488 GLSRRAQEWYQLQIQASDS 3506
Score = 305 bits (782), Expect = 4e-82
Identities = 331/1204 (27%), Positives = 516/1204 (42%), Gaps = 83/1204 (6%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRFFAVEPDTG 85
P F H ++ L +E+ VG+ V LLA D D+ P + + + + AS F++ P+
Sbjct: 2479 PEFQQHLYEAEL--AENAMVGTKVIDLLAIDKDSGPYGTIDYTIINKLASEKFSINPNGQ 2536
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIP 142
+ L Q LDRE +E + V G V V I + D NDN P F Y+V I
Sbjct: 2537 IATL-QKLDRENSTERVIAIKVMARDGGGRVAFCTVKIILTDENDNPPQFKASEYTVSIQ 2595
Query: 143 ENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS---QFFAIDSARGIVTVIRELDYETTQ 199
N +P+ V A D D G V YS P I+ G+V V L Q
Sbjct: 2596 SNVSKDSPVIQVLAYDADEGQNADVTYSVNPEDLVKDVIEINPVTGVVKVKDSLVGLENQ 2655
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
+ A D ++L + + + + P F Y+ + E P G+ + I+
Sbjct: 2656 TLDFFIKAQDGGPPH-WNSLVPVRLQVVPKKVSLPKFSEPLYTFSAPEDLPEGSEIGIVK 2714
Query: 260 AID-QDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENP-LYSHGFILTVKGT 317
A+ QD + T N + +F+LD +GV+ + +D E+ LY + V
Sbjct: 2715 AVAAQDPVIYSLVRGTTPESNKDGVFSLDPDTGVIKVRKPMDHESTKLYQ----IDVMAH 2770
Query: 318 ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
L + +D + NI V D+NDN P F + Y +TE VG ++ + + +DKD
Sbjct: 2771 CLQN----TDVVSLVSVNIQVGDVNDNRPVFEADPYKAVLTENMPVGTSV-IQVTAIDKD 2825
Query: 378 ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-- 435
+ + ++ H + + S G I LD ET Y F + A +
Sbjct: 2826 TGRDGQVSYRLSADPGSNVHELFAIDSESGW----ITTLQELDCETCQTYHFHVVAYDHG 2881
Query: 436 SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGE- 494
A V++++ +ENDN P F+ Y S+ EN G V T+ D D
Sbjct: 2882 QTIQLSSQALVQVSITDENDNAPRFASEEYRGSVVENSEPGELVATLKTLDADISEQNRQ 2941
Query: 495 -VSYFFSDDP-DRFSLDK--DTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRIN 550
Y DP +F + + D I LD E ++ L + A DG + + V I
Sbjct: 2942 VTCYITEGDPLGQFGISQVGDEWRISSRKTLDREHTAKYLLRVTASDGKFQASV-TVEIF 3000
Query: 551 VLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF 610
VLDVNDN P + Y G + E+ ++++ ATD D+ N QITYS+ A
Sbjct: 3001 VLDVNDNSPQCSQLLYTGKVHEDVFPGHFILKVSATDLDTDTNAQITYSLHGPGAH---- 3056
Query: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT 670
+ L G ++ LD E+ + L A D G + + T+ V D NDN P
Sbjct: 3057 EFKLDPHTGELTTLTALDRER--KDVFNLVAKATDGGGRSCQADI--TLHVEDVNDNAPR 3112
Query: 671 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEI 728
F V+V +N V + A D D+ ++YSL S + F I+A +G I
Sbjct: 3113 FFPSHCAVAVFDNTTVKTPVAVVFARDPDQG---ANAQVVYSLPDSAEGHFSIDATTGVI 3169
Query: 729 TTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLV 788
L ++ L VRA D G T + TV ++++ + D P + + + + +
Sbjct: 3170 RLEKPLQVRPQAPLELTVRASDLGTPIPLST-LGTVTVSVVGLEDYLPVFLNTEHSVQVP 3228
Query: 789 EMTPPDSDVTTVVAVD-PDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDP 847
E PP ++V + + P + G V S +F L++ TG I +A LD E
Sbjct: 3229 EDAPPGTEVLQLATLTRPGAEKTGYRVVSGNEQGRF-RLDARTG-ILYVNASLDFETSPK 3286
Query: 848 H--EAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
+ E RK S++D TV VN+ D+N++ P F P+ VLE
Sbjct: 3287 YFLSIECSRKSSSSLSDV----------TTVMVNITDVNEHRPQFPQDPYSTRVLENALV 3336
Query: 906 GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRV 965
G I V A D D LN ++Y + G F I+ G + LDRE+ + Y L++
Sbjct: 3337 GDVILTVSATDEDGPLNSDITYSLIGGNQLGHFTIHPKKGELQVAKALDREQASSYSLKL 3396
Query: 966 VASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVG 1025
A+D+G P + + I V DVND P FF Y+ +V E+ P +V+ L +D D
Sbjct: 3397 RATDSGQPPLHEDTDIAIQVADVNDNPPRFFQLNYSTTVQENSPIGSKVLQLILSDPDSP 3456
Query: 1026 LNA-ELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNG--PVGKRH 1082
N S+ IT GN F V D + T GL R Y L ++A D+G P+
Sbjct: 3457 ENGPPYSFRITKGNNGSAFRV-TPDGWLVTAEGLSRRAQEWYQLQIQASDSGIPPL---- 3511
Query: 1083 TGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRIL 1142
+ +V V V + + P L +V ED +G + ++ ATD D + + Y +
Sbjct: 3512 SSLTSVRVHVTEQSHYAPSALPLEIFITVGEDEFQGGMVGKIHATDRDPQD--TLTYSLA 3569
Query: 1143 HGNH-GNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDI 1201
G +F + +G ++ + L R S +V + + G ++ V VYV +
Sbjct: 3570 EEETLGRHFSVGAPDGKII-AAQGLPRGHYSFNVTVSD------GTFTTTAGVHVYVWHV 3622
Query: 1202 NDEA 1205
EA
Sbjct: 3623 GQEA 3626
Score = 109 bits (272), Expect = 5e-23
Identities = 141/586 (24%), Positives = 237/586 (40%), Gaps = 78/586 (13%)
Query: 2388 VYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK 2447
V + I+D ND P+F PSY+ + ED+P+ + I VTATDAD G A Y+
Sbjct: 134 VVVHILDQNDLKPLFSPPSYRVTISEDMPLKSPICKVTATDADLGQNAEFYYAFNTRSEM 193
Query: 2448 FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
FAI+PT+G + V L+ + + L LA D ++ S+ ++ ++ P
Sbjct: 194 FAIHPTSGVVTVAGKLNVTWRGKHELQVLAVDRMRKISEGNGFGSLAALVVHVE-----P 248
Query: 2508 QFSKPQFSTSVYENEPA---GTSVITMMATDQDEGPNGELTYSLEG-PG-----VEAFHV 2558
KP SV P GT+ T++ G E + G PG ++++
Sbjct: 249 ALRKPPAIASVVVTPPDSNDGTTYATVLVDANSSGAEVESVEVVGGDPGKHFKAIKSYAR 308
Query: 2559 DMDSGLVTTQ--RPLQSYEKFSLTVVATDGGEPPLW----GTTMLLVEVIDVNDNRPVFV 2612
+ LV+ + ++ F+L++ A G P + G + ++ + + V+
Sbjct: 309 SNEFSLVSVKDINWMEYLHGFNLSLQARSGSGPYFYSQIRGFHLPPSKLSSLKFEKAVYR 368
Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGL 2672
+ + E P S V V T L ++ S F ++ +GL
Sbjct: 369 -------VQLSEFSPPGSRVVMVRVTPAFPNLQYVLKPSSENVG-------FKLNARTGL 414
Query: 2673 IQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQY 2732
I T + +D +A Y L + S P + + + + D +++ PLF R
Sbjct: 415 ITTTKLMDFHDRAHYQLHIRTS------PGQASTVVVIDIVDCNNHAPLFNRSSYDG--- 465
Query: 2733 QLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDL 2791
T+ E+ P GT V VT A D D G N V Y IA G + F + P G + + +
Sbjct: 466 ---TLDENIPPGTSVLAVT-ATDRDHGENGYVTYSIA-GPKALPFSIDPYLGIISTSKPM 520
Query: 2792 DRE-REAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAE 2850
D E + I++F V+AS W P + + L ++ND P F +
Sbjct: 521 DYELMKRIYTFRVRASD---WGSPFRREKEVSIFLQL---------RNLNDNQPMFEEVN 568
Query: 2851 YTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSM 2910
T + D VG ++ + A+D D N + Y N+ E F +
Sbjct: 569 CTGSIRQDWPVGKSIMTMSAIDVDELQN---------LKYEIVSGNELE----YFDLNHF 615
Query: 2911 DGIL---RTFDLFMAYSPGYFVVDIVARDLAGHNDTAIIGIYILRD 2953
G++ R F A P + + I A D + + I +++D
Sbjct: 616 SGVISLKRPFINLTAGQPTSYSLKITASDGKNYASPTTLNITVVKD 661
>gi|47059046 dachsous 2 isoform 1 [Homo sapiens]
Length = 2916
Score = 738 bits (1904), Expect = 0.0
Identities = 690/2424 (28%), Positives = 1094/2424 (45%), Gaps = 211/2424 (8%)
Query: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SD 501
A V++ L + NDN P+F+ Y S+ + GT ++ VLATD D+G +G V+Y +
Sbjct: 161 AFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGN 220
Query: 502 DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTF 561
F++D TGL + E++ + +E + + L + +
Sbjct: 221 VSSLFTIDSTTGLYSP----EVEILSAVNFS------ADKEVMNSLEM-FLPLLRHFKKV 269
Query: 562 QKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYF-DISLYEGYGV 620
++D A ++ E S +R + Q + A Y +++ G G+
Sbjct: 270 ERDEEA-AEKKFEASRGWFMRFKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGI 328
Query: 621 ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 680
I ++ PL + + + + L V A D G VTI +F P F +P Y V
Sbjct: 329 IYLTLPLSH--LESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLV 386
Query: 681 VENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST---QFRINARSGEITTTSLLDRE 737
E++ + + + A + S E I Y + +F I+ R G I T LD E
Sbjct: 387 YEDVPEDSPIGTVKAREPLNS----SEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHE 442
Query: 738 TKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDV 797
T+ +L V+A G T VNIT++D+NDNHP + I + + TPP + +
Sbjct: 443 TQPVVVLTVQAQLGSAPACSST---EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTAL 499
Query: 798 TTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKI 856
A D D G NG + YSI P ++++ G + ++ E + EL +
Sbjct: 500 YLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGE-----QRELT--L 552
Query: 857 VVSVTDCGRPPLKATSSATVFVNLLDLNDNDP--TFQNLPFVAEVLEGIPAGVSIYQVVA 914
+ D G P A TV +++ ++ P TF++L + EV E + + Q A
Sbjct: 553 TLRAEDQGVHPQAALLVLTV---VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQA 609
Query: 915 IDLD-EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA--SDAG 971
L + + Y + + F I +G + + D E Y RV A + G
Sbjct: 610 HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDG 669
Query: 972 TPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELS 1031
ST T+ + V D ND +PTF V + V E + + + D D G N +L
Sbjct: 670 FLQNVST-TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLL 728
Query: 1032 YFITGGNVDGKFS--------------VGYRDA-------------------VVRTV--- 1055
YF+ DGKF + + D V++++
Sbjct: 729 YFLLS---DGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCE 785
Query: 1056 ---------VGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
V LDRE + + + D G + T V+V+V D+NDNRP F Q
Sbjct: 786 LGEGELINWVALDREHRGHHEMTVLVTDRGSPPRN--ATMAVYVSVTDINDNRPFFPQCL 843
Query: 1107 YEASVPEDIPEGHSILQLKAT----DADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRG 1162
+ + EG + L T D DEG V Y + + ++F+I +NG + R
Sbjct: 844 PGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEI-RT 902
Query: 1163 PRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETA 1222
L + S+ + V A + + P++ V + V ++ + +Q L + E
Sbjct: 903 TTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQN-IRHLIIPENL 961
Query: 1223 GIGTSVIVVQATDR-DSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYM 1280
+ +++++D G +++ I++ +G FEID STG + LDYET + Y+
Sbjct: 962 KPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYL 1021
Query: 1281 MNVSATDQAPPFN-QGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYS 1339
V TD + + + I + ++ D + F + ++ EN+ +GT +V V
Sbjct: 1022 FRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGT-LVYVFNAK 1080
Query: 1340 IDNLNQITYRFNAYTSTQAKAL--FKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPK 1397
D+ + + R Y + F I G + +DRE LTV A D
Sbjct: 1081 DDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTASDQAVN 1140
Query: 1398 VDS----TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453
V ++ I +LD ND++P F S + ED VG V + A DPD G NG+
Sbjct: 1141 VTDRRLRSLTAQIVILDVNDHNPTF--ISFPNAHVKEDVTVGSLVHHITAHDPDEGRNGK 1198
Query: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
V +S+ SGN F + ++S G + PLD E +IL V+A D GTP L
Sbjct: 1199 VTYSILSGNENMTFML---DESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTL 1255
Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
VT+LD+ND PV + Y SV EN G V +V A DRD G+NS L + I G
Sbjct: 1256 TVTVLDVNDEAPVFKQHL-YEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASF 1314
Query: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPM 1633
F ++ +GE+ T DRE Q + L V D G P+LS+TT + T+ DEND+AP
Sbjct: 1315 ELFEINSDTGEVVTTTIL-DREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPE 1373
Query: 1634 FQQPHY--EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV 1691
F Y EVL ++ P+ + T L A D+D G N V Y I+ GN F I+ G
Sbjct: 1374 FIVSSYDIEVLENQEPEVVYTVL----ASDMDAGNNRAVEYHIIDGNTDECFTINEMSGE 1429
Query: 1692 ITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGP 1751
++ + LD E +TL++ +D + +S + V V D ND+ P+FP Y
Sbjct: 1430 LSTTRALDRE-QISNFTLVILCSD---LGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQS 1485
Query: 1752 FEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDR 1811
+ + G V A D+D G NGQ EY + D + G F I P+ G L+ LDR
Sbjct: 1486 SVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTD-EASGAFTIDPMSGTLKTSNT--LDR 1542
Query: 1812 ETIAFYNLTICARDRGMP-PLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFV 1870
E + + + ARD + S+T+++ + V D+NDNDPVL P ++ +S SP +
Sbjct: 1543 EARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTT 1602
Query: 1871 AHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
V A D D G N + F+ + F I+ TG + + E P + L + V D
Sbjct: 1603 VIVRADDLDLGPNGTVVFSFA--ETQSMFSIDKYTGEIQFQQNPSSEYFPIW-LQLKVTD 1659
Query: 1931 NPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA 1990
AR LL+I + E D F+ Y+ V EN AGT + + A D+
Sbjct: 1660 QGIP---ARTTTGLLVIHMEGE-DVKISFSHHLYKGLVTENCEAGTSIVTVKA--FAPDS 1713
Query: 1991 DQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLN 2050
QD + G + G+ + S +G +TV+ +D E + ++L++LAE G
Sbjct: 1714 IQDSMKYSIFS--GNEDGVLSLCSKSGQLTVKEPKFLDFEVRNE--VQLIVLAESSGH-R 1768
Query: 2051 STAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEA 2110
+ + + I D+NDN P F + + E+ V+QV ATD DSGLNG + Y I +
Sbjct: 1769 AYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILS 1828
Query: 2111 GAQDR-FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDIND 2169
G Q+ F I ++GVI A +D E SY L V ATD+G LS T ++ + + DIND
Sbjct: 1829 GNQEEAFQIDALSGVITT-KAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDIND 1887
Query: 2170 SRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQED 2229
+ P FL P + V + E + PG ++ +++ D DLN + AK+ N
Sbjct: 1888 NAPAFL-PSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSF----AKES------NPGT 1936
Query: 2230 AFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDN 2289
FA++ NTG V++ ++ E + YE+ + + D SV L V VLDVNDN
Sbjct: 1937 KFAIDQNTGVVVLVKTLDFEEMTEYELLIQISD--------SVHYTEGALVVRVLDVNDN 1988
Query: 2290 TPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDS 2349
P F +Y + E G +++ ++A D + N ++Y +L + ++
Sbjct: 1989 PPVFSQ---DFYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKEFSIDPKNG 2043
Query: 2350 SAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQE 2409
+ + +D + F V ASD G+P A V + I D+N+ P F SY
Sbjct: 2044 TIFTISPVLLLD--TISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNL 2101
Query: 2410 AVFEDVPVGTIILTVTATDAD-SGNFALIEYSLGDGESKFAINPTT------------GD 2456
++ ED VG+ ++T + D D + +EYS+ G S+ + T G
Sbjct: 2102 SLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGY 2161
Query: 2457 IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFST 2516
+ +L SLDRE + L LA D+ S+ + + IQVLDVND P FS + T
Sbjct: 2162 LVLLHSLDREASASHELVILASDSGCPPLSS----TAVISIQVLDVNDNPPNFSSLSYHT 2217
Query: 2517 SVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPL--QS 2573
V E+ P G+ + + A D+D G + E+ Y++ G F+++ ++G++ +PL +
Sbjct: 2218 HVKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEK 2277
Query: 2574 YEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVY 2633
KF+LTV A+D E + ++ V V+D ND+ P F+ I + E +P+ S +
Sbjct: 2278 MTKFTLTVQASDA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCI--VPENLPISSTIC 2334
Query: 2634 EVYATDKDEGLNGAVRYS-----FLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYS 2688
+ A D D G G + YS FL + D + F+IDP++G I Q LD E+ Y
Sbjct: 2335 SINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYC 2394
Query: 2689 LILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG 2748
L + A D G + V +E ID+ EP+F + QY T+PE + L+G
Sbjct: 2395 LTVQAKDKGDAT---ASLVVWVDIEGIDEFEPIFTQ-----DQY-FFTLPEKNKDRQLIG 2445
Query: 2749 NVTGAVDADEGPNAIVYYFIAAGN 2772
V A DAD G + ++ Y + +
Sbjct: 2446 RVE-ASDADAGIDGVILYSLGTSS 2468
Score = 650 bits (1678), Expect = 0.0
Identities = 613/2169 (28%), Positives = 986/2169 (45%), Gaps = 190/2169 (8%)
Query: 41 LISEDTPVGSSVTQLLAQDMDN--DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
L+ ED P S + + A++ N +P+ + +S + F++ P G + R+PLD ET+
Sbjct: 385 LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQ 444
Query: 99 SE--FTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNA 156
TV+ + + +VNI V DVNDN P F +RI + TP GT +++ A
Sbjct: 445 PVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 504
Query: 157 TDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
D D G G + YS P FAID A G++ + L + LT+ A DQ P
Sbjct: 505 EDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG-VHP 563
Query: 216 LSTLANLAIIITDVQDMDP--IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG--- 270
+ L L ++I + ++ P F +L Y + E P +T + Q + P G
Sbjct: 564 QAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSP------MTQMLQTQAHPLGPQR 616
Query: 271 ----IGYTIVSGNTNSIFALDYISGVLTLNGLLDRENP-LYSHGFILTVKGTELNDDRTP 325
+ Y++ +++F + +G + L D E+ Y+ + P
Sbjct: 617 AASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI----------P 666
Query: 326 SDA---TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL 382
D V+TT + V D NDN+P F + + E + V + I +D D G
Sbjct: 667 EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE-SPVPQGVIGKITAIDMDS--GK 723
Query: 383 NSMFEVYLVGNNSHH----------------------------FIISPTSVQ-------- 406
N +L+ + F S +Q
Sbjct: 724 NGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLF 783
Query: 407 ---GKADIRIRVAIPLDYETVDRYDFD-LFANESVPDHVGYAKVKITLINENDNRPIFSQ 462
G+ ++ VA LD E ++ L + P V +++ + NDNRP F Q
Sbjct: 784 CELGEGELINWVA--LDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQ 841
Query: 463 PL----YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS--DDPDRFSLDKDTGLIM 516
L ++ + E V V TV A D D G EV+Y S D D F +D + G I
Sbjct: 842 CLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIR 901
Query: 517 LIARLDYELIQRFTLTIIARDGGGEETTGR--VRINVLDVNDNVPTFQKDAYVGALRENE 574
L Y+ + +++IA D G G+ V I V+ ++ ++ + EN
Sbjct: 902 TTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENL 961
Query: 575 PSVTQLVRLRATDE-DSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQIS 633
+ ++++D N ++ +SIV+ G +F+I G + +S+ LDYE S
Sbjct: 962 KPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDG-HFEID--SSTGDLFLSKELDYETTS 1018
Query: 634 NGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFL 693
+ ++ + + N L+STV ++I+V D+ND+ P+F +SV EN+ G V
Sbjct: 1019 H-YLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVF 1077
Query: 694 NATDLDRSREYGQESIIYSLE----GSTQFRINARSGEITTTSLLDRETKSEYILIVRAV 749
NA D D S + I Y +E G+ F I+ G + T S LDRE+ IL V A
Sbjct: 1078 NAKDDDGS--FLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRESIPTVILTVTAS 1135
Query: 750 DGGVG-HNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLG 808
D V +++ T I +LD+ND++PT+ P ++ E S V + A DPD G
Sbjct: 1136 DQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKEDVTVGSLVHHITAHDPDEG 1194
Query: 809 ENGTLVYSIQPPNK--FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRP 866
NG + YSI N+ + L+ ++G + TT P +E + + V D G P
Sbjct: 1195 RNGKVTYSILSGNENMTFMLDESSGLLTTT-------CPLDYEMKTQHILTVLALDDGTP 1247
Query: 867 PLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVS 926
L +SS T+ V +LD+ND P F+ + A V E G + +V A+D D G+N +
Sbjct: 1248 AL--SSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQ 1305
Query: 927 YRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVL 986
+ + G F INS +G VVTTT LDRE + LRV+ D G P+ SST+T+ V
Sbjct: 1306 FEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVE 1365
Query: 987 DVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVG 1046
D ND P F + Y++ V E+ E V + +D D G N + Y I GN D F++
Sbjct: 1366 DENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTDECFTIN 1424
Query: 1047 YRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
+ T LDRE + + L++ D G + + + V VLD ND+ P F
Sbjct: 1425 EMSGELSTTRALDREQISNFTLVILCSDLGDPPR--SSVIHLQVRVLDANDHSPSFPTLY 1482
Query: 1107 YEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPL 1166
Y++SV ED G +L L A D DEG G+ Y L F I +G L + L
Sbjct: 1483 YQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEY-FLTDEASGAFTIDPMSGTL-KTSNTL 1540
Query: 1167 DRERNSSHVLIVEAYNHDLGPMRSSVRVI-VYVEDINDEAPVFTQQQYSRLGLRETAGIG 1225
DRE S H A + + RS+ +I VYV D+ND PV Q + + L +
Sbjct: 1541 DREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFD-VFLSPESPTN 1599
Query: 1226 TSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYM---MN 1282
+ ++V+A D D G G V + + + F ID+ TG I + Y +
Sbjct: 1600 QTTVIVRADDLDLGPNGTVVFS-FAETQSMFSIDKYTGEI----QFQQNPSSEYFPIWLQ 1654
Query: 1283 VSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
+ TDQ P + I + E D + FS+ Y+ + EN GT IV V+A++ D+
Sbjct: 1655 LKVTDQGIPARTTTGLLVIHMEGE-DVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS 1713
Query: 1343 LNQITYRFNAYTSTQAKALFKIDAITGVITVQ--GLVDREKGDFYTLTVVADDGGPKVDS 1400
+ Q + +++ ++ + + + + +G +TV+ +D E + L V+A+ G + +
Sbjct: 1714 I-QDSMKYSIFSGNE-DGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHR--A 1769
Query: 1401 TVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
KV + + DENDNSP F+ S S+ E V V A D D+G NG + +S+ S
Sbjct: 1770 YCKVAVLIQDENDNSPCFE-QSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILS 1828
Query: 1461 GNIAGAFEIVTTNDSIGEVFVARP-LDREELDHYILQVVASDRGTPPRKKDHILQVTILD 1519
GN AF+I D++ V + LD E Y L V A+D+G P +++V + D
Sbjct: 1829 GNQEEAFQI----DALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884
Query: 1520 INDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMD 1579
INDN P V + E+ G V V D D+ + S + E N F +D
Sbjct: 1885 INDNAPAFLP--SEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFS-FAKESNPGTKFAID 1941
Query: 1580 RISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHY 1639
+ +G + D E + Y L+ + D T A + V ++D NDN P+F Q Y
Sbjct: 1942 QNTG-VVVLVKTLDFEEMTEYELLIQISDSVHYTEGA---LVVRVLDVNDNPPVFSQDFY 1997
Query: 1640 EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699
+V + E + S++T+ A DL+ N ++Y I++ + F ID G I +
Sbjct: 1998 QVTVPES-IPVGYSVLTLSATDLESNEN--ISYRILSSS--KEFSIDPKNGTIFTISPVL 2052
Query: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP 1759
+ +V A+D + L + T V + + D+N+ P F +
Sbjct: 2053 LLDTISTTQFLVEASDGG---NPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALV 2109
Query: 1760 GPRVWTFLAHDRD-SGPNGQVEYSIMDGDPLGEFVIS--------PVEGVLRVRKDVELD 1810
G + TF D D + N VEYSI+ G+ F + P + V + LD
Sbjct: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169
Query: 1811 RETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFV 1870
RE A + L I A D G PPLSST ++ I+VLD+NDN P +L + + E++P+ S +
Sbjct: 2170 REASASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHI 2229
Query: 1871 AHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
V A+D D+G +A + +NI +GN + F++ TG++ + +PLD E++ ++ LT+ D
Sbjct: 2230 TVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD 2289
Query: 1931 NPENPRIARRDYDLLLIFLS--DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILAL 1988
++ + ++F+S D+ND+ P F S++ V EN P + + +N AL
Sbjct: 2290 ------AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSIN----AL 2339
Query: 1989 DADQDIYAVVTYQL---------LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILEL 2039
D D Y +TY + + LF I+ TG + + I+D E + L
Sbjct: 2340 DFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQ--ILDYENGNKYC--L 2395
Query: 2040 LLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSG 2099
+ A+D G ++ + + I ++ P F+ L E + +V A+D D+G
Sbjct: 2396 TVQAKDKGDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAG 2455
Query: 2100 LNGELVYRI 2108
++G ++Y +
Sbjct: 2456 IDGVILYSL 2464
Score = 629 bits (1622), Expect = e-179
Identities = 685/2525 (27%), Positives = 1084/2525 (42%), Gaps = 260/2525 (10%)
Query: 482 VLATDNDAGTFGEVSYFFSDD------PDRFSLDKDTGLIMLIARLDYELIQR-FTLTII 534
V A+D D+G +G + Y D P F +D G I + +D E + L +
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138
Query: 535 ARDG------------GGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVR 582
A+DG GG VR+++ DVNDN P F YV ++ + T+++
Sbjct: 139 AKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIIN 198
Query: 583 LRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVM 642
+ ATD+DS + Y ++ + S F I + GL V
Sbjct: 199 VLATDQDSGIYGTVAYELIPGNV-SSLFTIDS------------------TTGLYSPEVE 239
Query: 643 AMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSR 702
+ A N + V ++E+F F K E + F+
Sbjct: 240 ILSAVNFSADKEVMNSLEMFLPLLRH--FKKVERDEEAAEKKFEASRGWFMRFKGRRHLH 297
Query: 703 EYGQESIIYSLEGSTQFRINAR------SGEITTTSLLDRETKSEYILIVRAVDGGVGHN 756
+ S +G R A G I T L + L+V A DGG
Sbjct: 298 YLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGG---- 353
Query: 757 QKTGIATVNITLLDINDN-HPTWKDAPYYINLV-EMTPPDSDVTTVVAVDPDLGENGTLV 814
T + ++T+ P + P Y LV E P DS + TV A +P L + +
Sbjct: 354 GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIF 412
Query: 815 YSIQPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATS 872
Y I + +S++ G IRT P HE + +VV A S
Sbjct: 413 YRISSGDLGGKFSIHPRLGTIRT-------RKPLDHETQ---PVVVLTVQAQLGSAPACS 462
Query: 873 SATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVG 932
S V + ++D+NDN P F + + P G ++Y A D D G NGL+ Y +
Sbjct: 463 STEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASP 522
Query: 933 MPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDET 992
P + F I+ + GV+ L E L + A D G +++ LT+ V++ + +
Sbjct: 523 QPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV-VIEKREHS 580
Query: 993 P--TFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLN---AELSYFITGGNVDGKFSVGY 1047
P TF VY V VSE + ++ L + +G + L Y + F +
Sbjct: 581 PSWTFEHLVYQVEVSESLSPMTQM--LQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRP 638
Query: 1048 RDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSY 1107
+ D E+T Y + A ++ T TV V V D NDN P FL
Sbjct: 639 YTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVST-TVIVRVWDENDNSPTFLHDVL 697
Query: 1108 EASVPED-IPEGHSILQLKATDADEGEFGRVWYRILH-----------GNHGNNFRIHVS 1155
V E +P+G I ++ A D D G+ G++ Y +L G G + I +
Sbjct: 698 FLKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWA 756
Query: 1156 NGL--------------------------LMRGPR----PLDRERNSSHVLIVEAYNHDL 1185
+G L G LDRE H + V +
Sbjct: 757 DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGS 816
Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQ---QQYSRLGLRETAGIGTSVIVVQATDRDSGDGG 1242
P +++ V V V DIND P F Q + + + E + V V A D D G+
Sbjct: 817 PPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNA 876
Query: 1243 LVNYRILS-GAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301
V Y + S + F+ID + G I T L Y+ + SY M+V ATDQ P QG V I
Sbjct: 877 EVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVVNI 936
Query: 1302 TLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAK-- 1359
++ S I ENL T+I+ + S D+L Q Y + S A
Sbjct: 937 QVIPLSKGRAIMSQNIRHLIIPENLK-PTKIMSL-IKSSDHLQQ-HYNGKLHFSIVADDK 993
Query: 1360 -ALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVD--STVKVYITVLDENDNSP 1416
F+ID+ TG + + +D E Y V+ D + STV + I V D+ND+SP
Sbjct: 994 DGHFEIDSSTGDLFLSKELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSP 1053
Query: 1417 RFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGS-NGQVVFSLASGNIAGAFEIVTTNDS 1475
F +S+ E+ P+G V A D D N ++ + + S N ++ + S
Sbjct: 1054 SFQ-DELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLI--HPS 1110
Query: 1476 IGEVFVARPLDREELDHYILQVVASDRG---TPPRKKDHILQVTILDIND-NPPVIESPF 1531
G + LDRE + IL V ASD+ T R + Q+ ILD+ND NP I P
Sbjct: 1111 FGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP- 1169
Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
N V E+V G+ V + A D D G N ++Y I GN++M F +D SG + T P
Sbjct: 1170 --NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSG-LLTTTCP 1226
Query: 1592 PDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLN 1651
D E ++ + L D+GTP LS++ + VT++D ND AP+F+Q YE + E +
Sbjct: 1227 LDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP-G 1285
Query: 1652 TSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIV 1711
+ ++ALD D G N + + I+ G F I+ G + LD EI ++
Sbjct: 1286 EFVTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVL 1345
Query: 1712 TATDQCPILSHRLTSTTTVLVNVNDINDNVPTF-PRDYEGPFEVTEGQPGPRVWTFLAHD 1770
P LS STTT+L V D ND+ P F Y+ EV E Q V+T LA D
Sbjct: 1346 VRDGGFPSLS----STTTILCTVEDENDHAPEFIVSSYD--IEVLENQEPEVVYTVLASD 1399
Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
D+G N VEY I+DG+ F I+ + G L + LDRE I+ + L I D G PP
Sbjct: 1400 MDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTR--ALDREQISNFTLVILCSDLGDPP 1457
Query: 1831 LSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI 1890
SS + + +RVLD ND+ P L ++ E++ V + V + A D D G N + + +
Sbjct: 1458 RSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFL 1517
Query: 1891 TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
T AF I+ +G + + LDRE ++ + +D + + +R ++ ++++
Sbjct: 1518 T-DEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDC--SIQGSRSTTVIIKVYVT 1574
Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLF 2010
D NDN P+ ++ + + SP ++ A D D V + QS +F
Sbjct: 1575 DVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR----ADDLDLGPNGTVVFSFAETQS-MF 1629
Query: 2011 DINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFS 2070
I+ TG + + + P L+L + + I +T LL+ ++ D + +FS
Sbjct: 1630 SIDKYTGEIQFQQN---PSSEYFPIWLQLKVTDQGIPARTTTG-LLVIHMEGEDVKISFS 1685
Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTGVIRVGN 2129
+ ENC G S++ V A DS + + Y I +G +D L + +G + V
Sbjct: 1686 HHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKSGQLTVKE 1744
Query: 2130 AT-IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAE 2188
+D E + +L V+A G V +LI D ND+ P F I SV ES
Sbjct: 1745 PKFLDFEVRNEVQLIVLAESSGH---RAYCKVAVLIQDENDNSPCFEQSIYQASVSESQL 1801
Query: 2189 PGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPM 2246
+ + A D D LN +EY I L NQE+AF ++ +G + K+ +
Sbjct: 1802 YNAHVIQVFATDLDSGLNGLIEYSI-----------LSGNQEEAFQIDALSGVITTKAIL 1850
Query: 2247 NRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERIL 2306
+ EL ++Y + + D +P S + + V V D+NDN P F P I
Sbjct: 1851 DYELTSSYSLIVQATDKG--MPRLSNTTV---IKVQVTDINDNAPAFLPSEAV----EIT 1901
Query: 2307 EGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVH 2366
E + PG + V+ D D LN ++ PG D + G V+ +T+D+EE+
Sbjct: 1902 EDSLPGVIVTHVSVHDVD--LNSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFEEMT 1959
Query: 2367 WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTA 2426
++ SD+ A + + ++D+NDN P+F Q YQ V E +PVG +LT++A
Sbjct: 1960 EYELLIQISDSVHYTEGALV---VRVLDVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
Query: 2427 TDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSS---LDREKKDHYILTALAKDNPGD 2483
TD +S I Y + +F+I+P G I+ +S LD +++ A NP
Sbjct: 2017 TDLESNEN--ISYRILSSSKEFSIDPKNGTIFTISPVLLLDTISTTQFLVEASDGGNP-- 2072
Query: 2484 VASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD-EGPNG 2542
R V++ I+ D+N+ P+F+ ++ S+ E+ G++++T D D N
Sbjct: 2073 --DLRALTLVEIGIE--DMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENT 2128
Query: 2543 ELTYSL-EGPGVEAFHVDM----------DSGLVTTQRPL--QSYEKFSLTVVATDGGEP 2589
+ YS+ G FHV+ G + L ++ L ++A+D G P
Sbjct: 2129 YVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCP 2188
Query: 2590 PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVR 2649
PL T ++ ++V+DVNDN P F T H++E PL S++ V A D+D G + +
Sbjct: 2189 PLSSTAVISIQVLDVNDNPPNFSSLSYHT--HVKESTPLGSHITVVSANDRDTGSHAEII 2246
Query: 2650 YSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQ 2709
Y+ + +GN F++ + +G++ + LD E ++L + ASD + + + +
Sbjct: 2247 YNII--SGNEKGHFYL-EENTGVLYLIKPLDYEKMTKFTLTVQASDAEKK--HFSFAVVF 2301
Query: 2710 VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIA 2769
V++ D +D+ P F+ VPE+ P + + ++ A+D D GP + Y I
Sbjct: 2302 VSVLDDNDHAPQFMFSSFSC------IVPENLPISSTICSIN-ALDFDAGPYGELTYSIV 2354
Query: 2770 A--------GNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPT 2820
+ + F + P G + + LD E + V+A
Sbjct: 2355 SPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKG----------- 2403
Query: 2821 LDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSL 2880
D A L V V +E I++ P FT+ +Y + K + +V A DAD G + +
Sbjct: 2404 -DATASLV---VWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDADAGIDGV 2459
Query: 2881 VFYSI 2885
+ YS+
Sbjct: 2460 ILYSL 2464
Score = 629 bits (1621), Expect = e-179
Identities = 664/2546 (26%), Positives = 1129/2546 (44%), Gaps = 262/2546 (10%)
Query: 258 ITAIDQDKGRPRGIGYTIVSG----NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILT 313
+TA D D G I Y++ G F +D G + ++ +DRE ++ ++
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVE 138
Query: 314 VKGTELNDDRTPSDATVTTTFNILVI------DINDNAPEFNSSEYSVAITELAQVGFAL 367
K + + R A V + D+NDN P FN S Y +I++ Q G +
Sbjct: 139 AKDGD--EQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
Query: 368 PLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDR 426
I V+ D++ G+ L+ GN S F I T+ ++ I A+ +
Sbjct: 197 ---INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEILSAVNFSADKEVM 253
Query: 427 YDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATD 486
++F +P + KV E D + + + + + D
Sbjct: 254 NSLEMF----LPLLRHFKKV------ERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQD 303
Query: 487 NDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETT-- 544
A GE + + + + + G+I L L + +L + A+DGGG
Sbjct: 304 EAASADGEAAARYVANLAKILGE---GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVIN 360
Query: 545 GRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS 604
V I++ F++ Y + E+ P + + ++A E + I Y I S
Sbjct: 361 ADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGD 419
Query: 605 AFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDE 664
G + S++ G I +PLD+E + ++ LTV A G+ P S+ V I V D
Sbjct: 420 LGGKF---SIHPRLGTIRTRKPLDHE--TQPVVVLTVQAQ-LGSAPACSSTEVNITVMDV 473
Query: 665 NDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ---FRI 721
NDN P F + + + + + G + A D R+ G+ +I S Q F I
Sbjct: 474 NDNHPAFLRTSDEIRISQTTPPGTALYLARAED----RDSGRNGLIRYSIASPQPGVFAI 529
Query: 722 NARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTW--K 779
+ G + L + E L +RA D GV + TV +++ ++ P+W +
Sbjct: 530 DRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV---VIEKREHSPSWTFE 586
Query: 780 DAPYYINLVEMTPPDSDVTTVVA--VDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
Y + + E P + + A + P + L YS++P + + + TG I
Sbjct: 587 HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAAS-PLRYSLEPSVDSAMFGIRPYTGWIYL 645
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
D E+ + ++ + + G S TV V + D NDN PTF +
Sbjct: 646 RR-QFDYESTQTYNF----RVFAWIPEDG---FLQNVSTTVIVRVWDENDNSPTFLHDVL 697
Query: 896 VAEVLEG-IPAGVSIYQVVAIDLDEGLNGLVSYRM--------------PVG-------- 932
+V E +P GV I ++ AID+D G NG + Y + P G
Sbjct: 698 FLKVEESPVPQGV-IGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWA 756
Query: 933 -----MPRMDFLINSSS---------------GVVVTTTELDRERIAEYQLRVVASDAGT 972
DF +S G ++ LDRE +++ V+ +D G+
Sbjct: 757 DGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGS 816
Query: 973 PTKSSTSTLTIHVLDVNDETPTFFPAVY-----NVSVSEDVPREFRVVWLNCTDNDVGLN 1027
P +++T + + V D+ND P FFP +V V E P V + D D G N
Sbjct: 817 PPRNATMAVYVSVTDINDNRP-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNN 875
Query: 1028 AELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTAT 1087
AE++Y ++ + F + + +RT L + +Y + + A D G + G A
Sbjct: 876 AEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQ--GQAV 933
Query: 1088 VFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF-GRVWYRILHGNH 1146
V + V+ ++ R I Q+ +PE++ + +K++D + + G++ + I+ +
Sbjct: 934 VNIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDK 993
Query: 1147 GNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG-PMRSSVRVIVYVEDINDEA 1205
+F I S G L + LD E S ++ V +H + S+V + + VED ND +
Sbjct: 994 DGHFEIDSSTGDLFLS-KELDYETTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHS 1052
Query: 1206 PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK------FEID 1259
P F Q + + + E IGT V V A D DG +N RI E F I
Sbjct: 1053 PSF-QDELIVISVEENVPIGTLVYVFNAKD---DDGSFLNSRIQYYIESHNPGTNPFLIH 1108
Query: 1260 ESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQG---FCSVYITLLNELDEAVQFSNA 1316
S G ++TV+ LD E+ + ++ V+A+DQA + I +L+ D F +
Sbjct: 1109 PSFGTLVTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISF 1168
Query: 1317 SYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
A + E++ +G+ + + A+ D ++TY + S F +D +G++T
Sbjct: 1169 P-NAHVKEDVTVGSLVHHITAHDPDEGRNGKVTY---SILSGNENMTFMLDESSGLLTTT 1224
Query: 1375 GLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCP 1433
+D E + LTV+A DDG P + S+ + +TVLD ND +P F A S+ E+
Sbjct: 1225 CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEA-SVKENQN 1283
Query: 1434 VGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHY 1493
G+ V V+A D D+G N ++ F + G +FE+ N GEV LDRE + +
Sbjct: 1284 PGEFVTRVEALDRDSGVNSKLQFEIMPG---ASFELFEINSDTGEVVTTTILDREIQEVF 1340
Query: 1494 ILQVVASDRGTPPRKKDHILQVTILDINDNPP--VIESPFGYNVSVNENVGGGTAVVQVR 1551
L+V+ D G P + T+ D ND+ P ++ S Y++ V EN V V
Sbjct: 1341 TLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSS---YDIEVLENQEP-EVVYTVL 1396
Query: 1552 ATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGT 1611
A+D D G N + Y+I +GN D F ++ +SGE++T A DRE+ S + LV D G
Sbjct: 1397 ASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRAL-DREQISNFTLVILCSDLGD 1455
Query: 1612 PTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVT 1671
P S+ H+ V ++D ND++P F +Y+ + E + + T ++ + A+D DEG NG
Sbjct: 1456 PPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVREDAE-VGTVVLVLSAVDKDEGLNGQTE 1514
Query: 1672 YAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVL 1731
Y + F ID G + + LD E + ++T A D C I R T T +
Sbjct: 1515 Y-FLTDEASGAFTIDPMSGTLKTSNTLDRE-ARSQHTFSAVARD-CSIQGSRST-TVIIK 1570
Query: 1732 VNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFL---AHDRDSGPNGQVEYSIMDGDP 1788
V V D+NDN P ++ PF+V P T + A D D GPNG V +S +
Sbjct: 1571 VYVTDVNDNDPVLEQN---PFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSFAETQS 1627
Query: 1789 LGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDND 1848
+ F I G ++ +++ + I L + D+G+P ++T L+ I + + +
Sbjct: 1628 M--FSIDKYTGEIQFQQNPSSEYFPIW---LQLKVTDQGIPARTTTGLLVIHM----EGE 1678
Query: 1849 PVLLNLPMNI---TISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATT 1905
V ++ ++ ++EN + + V A DS + ++I +GN + + + +
Sbjct: 1679 DVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKS 1737
Query: 1906 GIVTVNRP--LDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKST 1963
G +TV P LD E E +L + + + R Y + + + DENDN P F +S
Sbjct: 1738 GQLTVKEPKFLDFEVRNEVQLIVLAESS------GHRAYCKVAVLIQDENDNSPCFEQSI 1791
Query: 1964 YQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVR 2022
YQA V E+ + + A D D + ++ Y +L G Q F I++ +GV+T +
Sbjct: 1792 YQASVSESQLYNAHVI----QVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK 1847
Query: 2023 SGVIIDREAFSPPILELLLLAEDIGL--LNSTAHLLITILDDNDNRPTFSPATLTVHLLE 2080
+ I+D E S L++ A D G+ L++T + + + D NDN P F P+ V + E
Sbjct: 1848 A--ILDYELTSS--YSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSE-AVEITE 1902
Query: 2081 NCPPGFSVLQVTATDEDSGLNGELVYRI--EAGAQDRFLIHLVTGVIRVGNATIDREEQE 2138
+ PG V V+ D D LN ++ E+ +F I TGV+ V T+D EE
Sbjct: 1903 DSLPGVIVTHVSVHDVD--LNSAFIFSFAKESNPGTKFAIDQNTGVV-VLVKTLDFEEMT 1959
Query: 2139 SYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITA 2198
Y L + +D G +V +L D+ND+ P F V+V ES G + ++A
Sbjct: 1960 EYELLIQISD-SVHYTEGALVVRVL--DVNDNPPVFSQDFYQVTVPESIPVGYSVLTLSA 2016
Query: 2199 IDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSP-MNRELVATYEVT 2257
D + N + Y I+ + F+++ G++ SP + + ++T +
Sbjct: 2017 TDLESNENISYRIL-------------SSSKEFSIDPKNGTIFTISPVLLLDTISTTQFL 2063
Query: 2258 LSVIDNAS-DLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
+ D + DL R++++ + + + D+N+ P+F + Y + E A G+TL+
Sbjct: 2064 VEASDGGNPDL--RALTL----VEIGIEDMNNYAPEFT---VKSYNLSLSEDALVGSTLV 2114
Query: 2317 AVAAVDPD-KGLNGLVTYTLLDLVPPGYVQLEDS---------SAGKVIANRTVDYEEVH 2366
+ +D D N V Y+++ +E G ++ ++D E
Sbjct: 2115 TFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREASA 2174
Query: 2367 WLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTA 2426
+ ASD+G PP ++ + ++++D+NDN P F SY V E P+G+ I V+A
Sbjct: 2175 SHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVSA 2234
Query: 2427 TDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDV 2484
D D+G+ A I Y++ G K F + TG +Y++ LD EK + LT A D
Sbjct: 2235 NDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMTKFTLTVQASD----- 2289
Query: 2485 ASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGEL 2544
A + + V + VLD ND PQF FS V EN P +++ ++ A D D GP GEL
Sbjct: 2290 AEKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGEL 2349
Query: 2545 TYSLEGP---------GVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWG 2593
TYS+ P + F +D +G + ++ L ++ K+ LTV A D G+
Sbjct: 2350 TYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKDKGDAT--A 2407
Query: 2594 TTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFL 2653
+ ++ V++ +++ P+F + + + E+ R + V A+D D G++G + YS
Sbjct: 2408 SLVVWVDIEGIDEFEPIFTQ--DQYFFTLPEKNKDRQLIGRVEASDADAGIDGVILYSLG 2465
Query: 2654 KTAGNRDWEFFIIDPISGLIQTAQRL 2679
++ FF ++ +G I + L
Sbjct: 2466 TSS-----PFFSVNKTNGNIYLIRAL 2486
Score = 615 bits (1585), Expect = e-175
Identities = 653/2343 (27%), Positives = 1027/2343 (43%), Gaps = 243/2343 (10%)
Query: 71 GEEASRFFAVEPDT---GVVWLRQPLDRETKSEFTVEFSVSDHQG---VITRKVNIQVGD 124
GE A+R+ A G+++L PL + ++ S D G VI V I +
Sbjct: 310 GEAAARYVANLAKILGEGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQ 369
Query: 125 VNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQF--FAIDS 182
F Y+ + E+ P +PI V A +P L + + Y F+I
Sbjct: 370 TTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP-LNSSEPIFYRISSGDLGGKFSIHP 428
Query: 183 ARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYS 242
G + + LD+ET LTV A Q + P + + I + DV D P F+
Sbjct: 429 RLGTIRTRKPLDHETQPVVVLTVQA--QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDE 486
Query: 243 TNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRE 302
I + +PPGT + + A D+D GR I Y+I S +FA+D GVL LNG L
Sbjct: 487 IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAG 545
Query: 303 NPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE--FNSSEYSVAITEL 360
LT++ + P A + T +VI+ +++P F Y V ++E
Sbjct: 546 E---QRELTLTLRAEDQGVH--PQAALLVLT---VVIEKREHSPSWTFEHLVYQVEVSES 597
Query: 361 AQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIR-----IRV 415
P+ + + LG + + + P+ IR I +
Sbjct: 598 LS-----PMTQMLQTQAHPLGPQR-------AASPLRYSLEPSVDSAMFGIRPYTGWIYL 645
Query: 416 AIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLI----NENDNRPIFSQPLYNISLYE 471
DYE+ Y+F +FA +P+ V T+I +ENDN P F + + + E
Sbjct: 646 RRQFDYESTQTYNFRVFA--WIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE 703
Query: 472 NVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG------------------ 513
+ + + A D D+G G++ YF D F ++ +TG
Sbjct: 704 SPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFS 763
Query: 514 ---------------------------LIMLIARLDYELIQRFTLTIIARDGGG--EETT 544
LI +A LD E +T++ D G T
Sbjct: 764 GTDFAFSSDELQAFVLKSLFCELGEGELINWVA-LDREHRGHHEMTVLVTDRGSPPRNAT 822
Query: 545 GRVRINVLDVNDNVPTFQ-----KDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYS 599
V ++V D+NDN P F K+ +V L E +P + + A D D N ++TYS
Sbjct: 823 MAVYVSVTDINDNRPFFPQCLPGKELHVKVL-EGQPVNMLVTTVFAKDPDEGNNAEVTYS 881
Query: 600 IVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTI 659
+ S + +F I G + DY ++V+A D G PPL V I
Sbjct: 882 VSSEDS-SDHFKIDANNGEIRTTTILSYDYRPSYR----MSVIATDQGVPPLQGQAVVNI 936
Query: 660 EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESI-IYSLEGSTQ 718
+V + S+ + + EN+ + + ++D + G+ I + +
Sbjct: 937 QVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGH 996
Query: 719 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIAT---VNITLLDINDNH 775
F I++ +G++ + LD ET S Y+ V D H++ +++ ++I + D ND+
Sbjct: 997 FEIDSSTGDLFLSKELDYETTSHYLFRVITTD----HSKNLSLSSTVFLSIDVEDQNDHS 1052
Query: 776 PTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGE-NGTLVYSIQ---PPNKFYSLNSTTG 831
P+++D I++ E P + V A D D N + Y I+ P + ++ + G
Sbjct: 1053 PSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFG 1112
Query: 832 KIRTTHAMLDREN-PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF 890
+ T + LDRE+ P V+VTD + S T + +LD+ND++PTF
Sbjct: 1113 TLVTV-SRLDRESIPTVILTVTASDQAVNVTD------RRLRSLTAQIVILDVNDHNPTF 1165
Query: 891 QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTT 950
+ P A V E + G ++ + A D DEG NG V+Y + G M F+++ SSG++ TT
Sbjct: 1166 ISFPN-AHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTT 1224
Query: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDV-P 1009
LD E ++ L V+A D GTP SS+ TLT+ VLDVNDE P F +Y SV E+ P
Sbjct: 1225 CPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNP 1284
Query: 1010 REFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLI 1069
EF V + D D G+N++L + I G F + V T LDRE + L
Sbjct: 1285 GEF-VTRVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTTILDREIQEVFTLR 1343
Query: 1070 LEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDA 1129
+ D G + T T+ TV D ND+ P F+ SSY+ V E+ E + + A+D
Sbjct: 1344 VLVRDGG--FPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLEN-QEPEVVYTVLASDM 1400
Query: 1130 DEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG-PM 1188
D G V Y I+ GN F I+ +G L R LDRE+ S+ L++ DLG P
Sbjct: 1401 DAGNNRAVEYHIIDGNTDECFTINEMSGELST-TRALDREQISNFTLVILC--SDLGDPP 1457
Query: 1189 RSSV-RVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYR 1247
RSSV + V V D ND +P F Y + +RE A +GT V+V+ A D+D G G Y
Sbjct: 1458 RSSVIHLQVRVLDANDHSPSFPTLYY-QSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYF 1516
Query: 1248 ILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATD---QAPPFNQGFCSVYITLL 1304
+ A G F ID +G + T N LD E ++ + + A D Q VY+T +
Sbjct: 1517 LTDEASGAFTIDPMSGTLKTSNTLDREARSQHTFSAVARDCSIQGSRSTTVIIKVYVTDV 1576
Query: 1305 NELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKI 1364
N+ D ++ + + T IVR + + + F + +++F I
Sbjct: 1577 NDNDPVLEQNPFDVFLSPESPTNQTTVIVRADDLDLGPNGTVVFSF-----AETQSMFSI 1631
Query: 1365 DAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDS 1424
D TG I Q E + V D G P +T + + ++ D F
Sbjct: 1632 DKYTGEIQFQQNPSSEYFPIWLQLKVTDQGIP-ARTTTGLLVIHMEGEDVKISFSHHLYK 1690
Query: 1425 AVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARP 1484
+ + E+C G + TVKA+ PD+ + +S+ SGN G + + + G++ V P
Sbjct: 1691 GL-VTENCEAGTSIVTVKAFAPDS-IQDSMKYSIFSGNEDGVLSLCSKS---GQLTVKEP 1745
Query: 1485 --LDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVG 1542
LD E + L V+A G K + V I D NDN P E Y SV+E+
Sbjct: 1746 KFLDFEVRNEVQLIVLAESSGHRAYCK---VAVLIQDENDNSPCFEQSI-YQASVSESQL 1801
Query: 1543 GGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHL 1602
V+QV ATD D G+N ++ Y I GN++ AF++D +SG I T+ A D E S Y L
Sbjct: 1802 YNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITTK-AILDYELTSSYSL 1860
Query: 1603 VATVEDEGTPTLSATTHVYVTIVDENDNAPMF-QQPHYEVLLDEGPDTLNTSLITIQALD 1661
+ D+G P LS TT + V + D NDNAP F E+ D P + T +++ +D
Sbjct: 1861 IVQATDKGMPRLSNTTVIKVQVTDINDNAPAFLPSEAVEITEDSLPGVIVTH-VSVHDVD 1919
Query: 1662 LDEGPNGTVTYAIV-AGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPIL 1720
L N ++ N F ID++ GV+ K LD+E Y L++ +D
Sbjct: 1920 L----NSAFIFSFAKESNPGTKFAIDQNTGVVVLVKTLDFE-EMTEYELLIQISDSVHYT 1974
Query: 1721 SHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVT--EGQP-GPRVWTFLAHDRDSGPNG 1777
L +V V D+NDN P F +D+ ++VT E P G V T A D +S N
Sbjct: 1975 EGAL------VVRVLDVNDNPPVFSQDF---YQVTVPESIPVGYSVLTLSATDLESNEN- 2024
Query: 1778 QVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLV 1837
+ Y I+ EF I P G + V L +TI+ + A D G P L + LV
Sbjct: 2025 -ISYRILSSSK--EFSIDPKNGTIFTISPVLL-LDTISTTQFLVEASDGGNPDLRALTLV 2080
Query: 1838 GIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD-SGCNARLTFNITAGNRE 1896
I + D+N+ P N+++SE++ V S + D D + N + ++I +GN +
Sbjct: 2081 EIGIEDMNNYAPEFTVKSYNLSLSEDALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQ 2140
Query: 1897 RAFFINA----------TTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
F + G + + LDRE ++L I D+ P + ++
Sbjct: 2141 NNFHVETKFFHSEYPYKQVGYLVLLHSLDREASASHELVILASDSGCPPLSSTA---VIS 2197
Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GA 2005
I + D NDN P F+ +Y V E++P G+ +TV++ A D D +A + Y ++ G
Sbjct: 2198 IQVLDVNDNPPNFSSLSYHTHVKESTPLGSHITVVS----ANDRDTGSHAEIIYNIISGN 2253
Query: 2006 QSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLN-STAHLLITILDDND 2064
+ G F + +TGV+ + +D E + L + A D + S A + +++LDDND
Sbjct: 2254 EKGHFYLEENTGVLYLIKP--LDYEKMTK--FTLTVQASDAEKKHFSFAVVFVSVLDDND 2309
Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGA---------QDR 2115
+ P F ++ + + EN P ++ + A D D+G GEL Y I + D
Sbjct: 2310 HAPQFMFSSFSCIVPENLPISSTICSINALDFDAGPYGELTYSIVSPCFLTHGMSYDHDL 2369
Query: 2116 FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFL 2175
FLI +TG I +D E Y LTV A D+G + + +V + I+ I++ P F
Sbjct: 2370 FLIDPLTGDIH-AKQILDYENGNKYCLTVQAKDKGDA--TASLVVWVDIEGIDEFEPIFT 2426
Query: 2176 NPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
++ E + +I + A D D I G++ + F+VN
Sbjct: 2427 QDQYFFTLPEKNKDRQLIGRVEASDADAG------IDGVILYS-----LGTSSPFFSVNK 2475
Query: 2236 NTGSV-------MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
G++ ++KS +N+E T E+ + SD S +V VNV ++
Sbjct: 2476 TNGNIYLIRALPLIKSQLNKE--DTLEMKIIAHSPKSDSKFASCTV-----FVNVSFSSE 2528
Query: 2289 NTP 2291
TP
Sbjct: 2529 GTP 2531
Score = 598 bits (1542), Expect = e-170
Identities = 591/2094 (28%), Positives = 932/2094 (44%), Gaps = 169/2094 (8%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
IS+ TP G+++ A+D D N + + ++ + FA++ GV++L L +
Sbjct: 489 ISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQ 547
Query: 99 SEFTVEFSVSDHQGVITRK---VNIQVGDVNDNAP--TFHNQPYSVRIPENTPVGTPIFI 153
E T+ D QGV + V V + +++P TF + Y V + E+ T +
Sbjct: 548 RELTLTLRAED-QGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQ 606
Query: 154 VNATDPDLG---AGGSVLYSFQPP--SQFFAIDSARGIVTVIRELDYETTQAYQLTVNAT 208
A LG A + YS +P S F I G + + R+ DYE+TQ Y V A
Sbjct: 607 TQAHP--LGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAW 664
Query: 209 DQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRP 268
+ + + + + D D P F++ + E P + ITAID D G+
Sbjct: 665 IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKN 724
Query: 269 RGIGYTIVS-----------GNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
+ Y ++S G +I+ + + G +G + F+L
Sbjct: 725 GQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFC 784
Query: 318 ELND------------------------DRTPSDATVTTTFNILVIDINDNAPEF----N 349
EL + DR T + V DINDN P F
Sbjct: 785 ELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLP 844
Query: 350 SSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVG--NNSHHFIISPTSVQG 407
E V + E V L V KD + G N+ Y V ++S HF I +
Sbjct: 845 GKELHVKVLEGQPVNM---LVTTVFAKDPDEG-NNAEVTYSVSSEDSSDHFKIDANN--- 897
Query: 408 KADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNI 467
+IR + DY R + ++ VP G A V I +I + R I SQ + ++
Sbjct: 898 -GEIRTTTILSYDYRPSYRMSV-IATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHL 955
Query: 468 SLYENVTVGTSVLTVLATDNDAGTFGEVSYF--FSDDPD-RFSLDKDTGLIMLIARLDYE 524
+ EN+ + + ++D+ + +F +DD D F +D TG + L LDYE
Sbjct: 956 IIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYE 1015
Query: 525 LIQRFTLTIIARDGGGE---ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLV 581
+ +I D +T + I+V D ND+ P+FQ + V ++ EN P T +
Sbjct: 1016 TTSHYLFRVITTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVY 1075
Query: 582 RLRATDED-SPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLT 640
A D+D S N++I Y I S + + F ++ +G + LD E I ++ +T
Sbjct: 1076 VFNAKDDDGSFLNSRIQYYIESHNPGTNPF--LIHPSFGTLVTVSRLDRESIPTVILTVT 1133
Query: 641 V--MAMDAGNPPLNSTVPVTIEVFDENDNPPTF-SKPAYFVSVVENIMAGATVLFLNATD 697
A++ + L S + I + D ND+ PTF S P V E++ G+ V + A D
Sbjct: 1134 ASDQAVNVTDRRLRS-LTAQIVILDVNDHNPTFISFPN--AHVKEDVTVGSLVHHITAHD 1190
Query: 698 LDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQ 757
D R I S + F ++ SG +TTT LD E K+++IL V A+D G
Sbjct: 1191 PDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGT--PA 1248
Query: 758 KTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI 817
+ T+ +T+LD+ND P +K Y ++ E P VT V A+D D G N L + I
Sbjct: 1249 LSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI 1308
Query: 818 QPPNKF--YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSAT 875
P F + +NS TG++ TT +LDR E + + + V V D G P L +T+ T
Sbjct: 1309 MPGASFELFEINSDTGEVVTT-TILDR------EIQEVFTLRVLVRDGGFPSLSSTT--T 1359
Query: 876 VFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPR 935
+ + D ND+ P F + EVLE V +Y V+A D+D G N V Y + G
Sbjct: 1360 ILCTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNNRAVEYHIIDGNTD 1418
Query: 936 MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF 995
F IN SG + TT LDRE+I+ + L ++ SD G P +SS L + VLD ND +P+F
Sbjct: 1419 ECFTINEMSGELSTTRALDREQISNFTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSF 1478
Query: 996 FPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTV 1055
Y SV ED V+ L+ D D GLN + YF+T G F++ ++T
Sbjct: 1479 PTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYFLT-DEASGAFTIDPMSGTLKTS 1537
Query: 1056 VGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDI 1115
LDRE + + A D G R T T + V V DVNDN P+ Q+ ++ + +
Sbjct: 1538 NTLDREARSQHTFSAVARDCSIQGSRST-TVIIKVYVTDVNDNDPVLEQNPFDVFLSPES 1596
Query: 1116 PEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1175
P + + ++A D D G G V + + F I G + P +
Sbjct: 1597 PTNQTTVIVRADDLDLGPNGTVVFSFAETQ--SMFSIDKYTGEIQFQQNP----SSEYFP 1650
Query: 1176 LIVEAYNHDLG-PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQAT 1234
+ ++ D G P R++ ++V + D F+ Y L + E GTS++ V+A
Sbjct: 1651 IWLQLKVTDQGIPARTTTGLLVIHMEGEDVKISFSHHLYKGL-VTENCEAGTSIVTVKAF 1709
Query: 1235 DRDSGDGGLVNYRILSGAE-GKFEIDESTGLIIT--VNYLDYETKTSYMMNVSATDQAPP 1291
DS + Y I SG E G + +G + +LD+E + + V A
Sbjct: 1710 APDSIQDSM-KYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSG-- 1766
Query: 1292 FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFN 1351
++ +C V + + +E D + F + Y+A++ E+ +++V A +D+ ++
Sbjct: 1767 -HRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYS 1825
Query: 1352 AYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLD 1410
+ Q +A F+IDA++GVIT + ++D E Y+L V A D G P++ +T + + V D
Sbjct: 1826 ILSGNQEEA-FQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884
Query: 1411 ENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIV 1470
NDN+P F AV I ED G V V D D N +FS A + G +
Sbjct: 1885 INDNAPA--FLPSEAVEITEDSLPGVIVTHVSVHDVDL--NSAFIFSFAKESNPGTKFAI 1940
Query: 1471 TTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESP 1530
N G V + + LD EE+ Y L + SD + L V +LD+NDNPPV
Sbjct: 1941 DQN--TGVVVLVKTLDFEEMTEYELLIQISD---SVHYTEGALVVRVLDVNDNPPVFSQD 1995
Query: 1531 FGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPA 1590
F Y V+V E++ G +V+ + AT D+ N +SY I +K+ F +D +G I T
Sbjct: 1996 F-YQVTVPESIPVGYSVLTLSAT--DLESNENISYRILSSSKE--FSIDPKNGTIFTISP 2050
Query: 1591 PPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTL 1650
+ S + D G P L A T V + I D N+ AP F Y + L E +
Sbjct: 2051 VLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDA-LV 2109
Query: 1651 NTSLITIQALDLD-EGPNGTVTYAIVAGNIVNTFRID----------RHMGVITAAKELD 1699
++L+T +D D N V Y+I++GN N F ++ + +G + LD
Sbjct: 2110 GSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLD 2169
Query: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQP 1759
E S +I+ + CP LS ST + + V D+NDN P F V E P
Sbjct: 2170 REASASHELVILASDSGCPPLS----STAVISIQVLDVNDNPPNF-SSLSYHTHVKESTP 2224
Query: 1760 -GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYN 1818
G + A+DRD+G + ++ Y+I+ G+ G F + GVL + K LD E + +
Sbjct: 2225 LGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIK--PLDYEKMTKFT 2282
Query: 1819 LTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDA 1878
LT+ A D S +V + VLD ND+ P + + + EN P+SS + + A D
Sbjct: 2283 LTVQASDAEKKHFSFA-VVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSINALDF 2341
Query: 1879 DSGCNARLTFNITA--------GNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKD 1930
D+G LT++I + F I+ TG + + LD E +Y LT+ KD
Sbjct: 2342 DAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTVQAKD 2401
Query: 1931 NPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA 1990
+ ++ + + ++ P+FT+ Y + E + L G + A DA
Sbjct: 2402 KGDATASL-----VVWVDIEGIDEFEPIFTQDQYFFTLPEKNKD----RQLIGRVEASDA 2452
Query: 1991 DQDIYAVVTYQLLGAQSGLFDINSSTG-VVTVRSGVIIDREAFSPPILELLLLA 2043
D I V+ Y LG S F +N + G + +R+ +I + LE+ ++A
Sbjct: 2453 DAGIDGVILYS-LGTSSPFFSVNKTNGNIYLIRALPLIKSQLNKEDTLEMKIIA 2505
Score = 578 bits (1491), Expect = e-164
Identities = 618/2184 (28%), Positives = 970/2184 (44%), Gaps = 218/2184 (9%)
Query: 798 TTVVAVDPDLGENGTLVYSI-------QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEA 850
T V A D D G G + YS+ + P F ++ G+I + +DRE DP
Sbjct: 77 TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAF-RIDPHDGQICVSQD-IDRER-DPATY 133
Query: 851 ELMRKIVVS----VTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAG 906
+L+ + +T ++ A V V+L D+NDN P F +V + + G
Sbjct: 134 DLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPG 193
Query: 907 VSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVV 966
I V+A D D G+ G V+Y + G F I+S++G+ E+ L V
Sbjct: 194 TEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGLYSPEVEI---------LSAV 244
Query: 967 ASDAGTPTKSSTS---TLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFR----VVWLNC 1019
A +S L H V + A S F+ + +L
Sbjct: 245 NFSADKEVMNSLEMFLPLLRHFKKVERDEEA---AEKKFEASRGWFMRFKGRRHLHYLKV 301
Query: 1020 TDNDVGLNAELS--YFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGP 1077
D + E + Y + G + ++ + L + L++ A D G
Sbjct: 302 QDEAASADGEAAARYVANLAKILG-------EGIIYLTLPLSHLESTTLSLMVSAQDGG- 353
Query: 1078 VGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRV 1137
G A V + + F + Y V ED+PE I +KA + +
Sbjct: 354 -GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSS-EPI 411
Query: 1138 WYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG--PMRSSVRVI 1195
+YRI G+ G F IH G + R +PLD E VL V+A LG P SS V
Sbjct: 412 FYRISSGDLGGKFSIHPRLGTI-RTRKPLDHETQPVVVLTVQA---QLGSAPACSSTEVN 467
Query: 1196 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK 1255
+ V D+ND P F + + + +T GT++ + +A DRDSG GL+ Y I S G
Sbjct: 468 ITVMDVNDNHPAFLRTS-DEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV 526
Query: 1256 FEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITL-LNELDEAVQFS 1314
F ID + G++ L + + + A DQ + + + E + F
Sbjct: 527 FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFE 586
Query: 1315 NASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQ 1374
+ Y+ + E+L+ T++++ QA+ + + + + A+F I TG I ++
Sbjct: 587 HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLR 646
Query: 1375 GLVDREKGDFYTLTVVA---DDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
D E Y V A +DG + ST V + V DENDNSP F D E+
Sbjct: 647 RQFDYESTQTYNFRVFAWIPEDGFLQNVSTT-VIVRVWDENDNSP--TFLHDVLFLKVEE 703
Query: 1432 CPVGQRV-ATVKAWDPDAGSNGQVVFSLASG----------NIAGAFEIVTTNDSI---- 1476
PV Q V + A D D+G NGQ+++ L S AG ++T D
Sbjct: 704 SPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVITWADGAAAFS 763
Query: 1477 -------------------------GEVFVARPLDREELDHYILQVVASDRGTPPRKKDH 1511
GE+ LDRE H+ + V+ +DRG+PPR
Sbjct: 764 GTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 823
Query: 1512 ILQVTILDINDNPPVIESPF---GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT 1568
+ V++ DINDN P +V V E V V A D D G N+ ++Y ++
Sbjct: 824 AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 883
Query: 1569 EGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEN 1628
+ F++D +GEI T R S Y + D+G P L V + ++ +
Sbjct: 884 SEDSSDHFKIDANNGEIRTTTILSYDYRPS-YRMSVIATDQGVPPLQGQAVVNIQVIPLS 942
Query: 1629 DNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRH 1688
+ Q +++ E + + L + NG + ++IVA + F ID
Sbjct: 943 KGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSS 1002
Query: 1689 MGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDY 1748
G + +KELDYE + Y V TD LS L+ST + ++V D ND+ P+F +D
Sbjct: 1003 TGDLFLSKELDYETT-SHYLFRVITTDHSKNLS--LSSTVFLSIDVEDQNDHSPSF-QDE 1058
Query: 1749 EGPFEVTEGQP-GPRVWTFLAHDRD-SGPNGQVEYSIMDGDP-LGEFVISPVEGVLRVRK 1805
V E P G V+ F A D D S N +++Y I +P F+I P G L
Sbjct: 1059 LIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVS 1118
Query: 1806 DVELDRETIAFYNLTICARDRGMPPLS---STMLVGIRVLDINDNDPVLLNLPMNITISE 1862
LDRE+I LT+ A D+ + ++ I +LD+ND++P ++ P N + E
Sbjct: 1119 --RLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDVNDHNPTFISFP-NAHVKE 1175
Query: 1863 NSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEY 1922
+ V S V H+ A D D G N ++T++I +GN F ++ ++G++T PLD E ++
Sbjct: 1176 DVTVGSLVHHITAHDPDEGRNGKVTYSILSGNENMTFMLDESSGLLTTTCPLDYEMKTQH 1235
Query: 1923 KLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLN 1982
LT+ D+ A L + + D ND P+F + Y+A V EN G +T
Sbjct: 1236 ILTVLALDDGTP---ALSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVT--- 1289
Query: 1983 GPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLL 2041
+ ALD D + + + ++++ GA LF+INS TG V + I+DRE L +L+
Sbjct: 1290 -RVEALDRDSGVNSKLQFEIMPGASFELFEINSDTGEVVTTT--ILDREIQEVFTLRVLV 1346
Query: 2042 LAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLN 2101
L+ST +L T+ D+ND+ P F ++ + +LEN P V V A+D D+G N
Sbjct: 1347 RDGGFPSLSSTTTILCTVEDENDHAPEFIVSSYDIEVLENQEPEV-VYTVLASDMDAGNN 1405
Query: 2102 GELVYRIEAGAQDR-FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIV 2160
+ Y I G D F I+ ++G + A +DRE+ ++ L ++ +D G P S +
Sbjct: 1406 RAVEYHIIDGNTDECFTINEMSGELSTTRA-LDREQISNFTLVILCSDLGDPPRSSVIHL 1464
Query: 2161 TILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKD 2218
+ + D ND P F SV E AE GTV+ ++A+D D LN + EY
Sbjct: 1465 QVRVLDANDHSPSFPTLYYQSSVREDAEVGTVVLVLSAVDKDEGLNGQTEYF-------- 1516
Query: 2219 DTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAK 2278
L AF ++ +G++ + ++RE A + T S + A D +
Sbjct: 1517 ----LTDEASGAFTIDPMSGTLKTSNTLDRE--ARSQHTFSAV--ARDCSIQGSRSTTVI 1568
Query: 2279 LTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDL 2338
+ V V DVNDN P + ++ E T TT+I V A D D G NG V ++ +
Sbjct: 1569 IKVYVTDVNDNDPVLEQNPFDVFLSP--ESPTNQTTVI-VRADDLDLGPNGTVVFSFAET 1625
Query: 2339 VPPGYVQLEDSSAGKV--IANRTVDYEEVHWLNFTVRASDNGSPPRAAE--IPVYLEIVD 2394
+ D G++ N + +Y + WL ++ +D G P R + +++E D
Sbjct: 1626 QSMFSI---DKYTGEIQFQQNPSSEYFPI-WLQ--LKVTDQGIPARTTTGLLVIHMEGED 1679
Query: 2395 INDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINP 2452
+ + F Y+ V E+ GT I+TV A DS ++ +YS+ G+ + ++
Sbjct: 1680 VKIS---FSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSM-KYSIFSGNEDGVLSLCS 1735
Query: 2453 TTGDIYVLSS--LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
+G + V LD E ++ L LA+ + +R V V+IQ D ND P F
Sbjct: 1736 KSGQLTVKEPKFLDFEVRNEVQLIVLAES-----SGHRAYCKVAVLIQ--DENDNSPCFE 1788
Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYS-LEGPGVEAFHVDMDSGLVTTQR 2569
+ + SV E++ VI + ATD D G NG + YS L G EAF +D SG++TT +
Sbjct: 1789 QSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEYSILSGNQEEAFQIDALSGVITT-K 1847
Query: 2570 PLQSYE---KFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEI 2626
+ YE +SL V ATD G P L TT++ V+V D+NDN P F+ P+ + + +
Sbjct: 1848 AILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTDINDNAPAFL--PSEAVEITEDSL 1905
Query: 2627 PLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAV 2686
P V + + D LN A +SF K + F ID +G++ + LD E
Sbjct: 1906 P---GVIVTHVSVHDVDLNSAFIFSFAKE--SNPGTKFAIDQNTGVVVLVKTLDFEEMTE 1960
Query: 2687 YSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTL 2746
Y L++ SD V Y T L V + D++DN P+F S + +TVPE P G
Sbjct: 1961 YELLIQISD---SVHY-TEGALVVRVLDVNDNPPVF------SQDFYQVTVPESIPVGYS 2010
Query: 2747 VGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRD-LDREREAIFSFIVK 2804
V ++ A D + N I Y +++ K F + P +G + + L + + F+V+
Sbjct: 2011 VLTLS-ATDLESNEN-ISYRILSS---SKEFSIDPKNGTIFTISPVLLLDTISTTQFLVE 2065
Query: 2805 ASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSE 2864
AS G +P L LTL E+ + ED+N+ P FT Y ++ DA VGS
Sbjct: 2066 ASD--------GGNPDL---RALTLVEIGI--EDMNNYAPEFTVKSYNLSLSEDALVGST 2112
Query: 2865 LIQVLALDAD-IGNNSLVFYSILA 2887
L+ +D D N+ V YSI++
Sbjct: 2113 LVTFSNIDHDWTRENTYVEYSIIS 2136
Score = 531 bits (1367), Expect = e-150
Identities = 588/2130 (27%), Positives = 911/2130 (42%), Gaps = 195/2130 (9%)
Query: 845 PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIP 904
P H ++VS D G L A +A V +++ F+ + V E +P
Sbjct: 334 PLSHLESTTLSLMVSAQDGGG--LTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVP 391
Query: 905 AGVSIYQVVAIDLDEGLNGL--VSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQ 962
I V A E LN + YR+ G F I+ G + T LD E
Sbjct: 392 EDSPIGTVKA---REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVVV 448
Query: 963 LRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDN 1022
L V A P SST + I V+DVND P F + +S+ P + D
Sbjct: 449 LTVQAQLGSAPACSSTE-VNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDR 507
Query: 1023 DVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRH 1082
D G N + Y I G F++ V+ L L L A D G H
Sbjct: 508 DSGRNGLIRYSIASPQ-PGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGV----H 562
Query: 1083 TGTATVFVTV-LDVNDNRP--IFLQSSYEASVPEDIPEGHSILQLKATD-ADEGEFGRVW 1138
A + +TV ++ ++ P F Y+ V E + +LQ +A + +
Sbjct: 563 PQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPLR 622
Query: 1139 YRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRS-SVRVIVY 1197
Y + F I G + R D E ++ V A+ + G +++ S VIV
Sbjct: 623 YSLEPSVDSAMFGIRPYTGWIYLR-RQFDYESTQTYNFRVFAWIPEDGFLQNVSTTVIVR 681
Query: 1198 VEDINDEAPVFTQQQYSRLGLR-ETAGIGTSVI-VVQATDRDSGDGGLVNYRILS----- 1250
V D ND +P F + L L+ E + + VI + A D DSG G + Y +LS
Sbjct: 682 VWDENDNSPTFL---HDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFF 738
Query: 1251 -------------------------GAEGKFEIDESTGLIIT-----------VNY--LD 1272
G + F DE ++ +N+ LD
Sbjct: 739 KMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALD 798
Query: 1273 YETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNA----SYEAAILENLAL 1328
E + + M V TD+ P +VY+++ + D F +LE +
Sbjct: 799 REHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPV 858
Query: 1329 GTEIVRVQAYSIDNLN--QITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYT 1386
+ V A D N ++TY ++ S+ FKIDA G I ++ + Y
Sbjct: 859 NMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDH---FKIDANNGEIRTTTILSYDYRPSYR 915
Query: 1387 LTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWD 1445
++V+A D G P + V I V+ + + IPE+ + ++ +K+ D
Sbjct: 916 MSVIATDQGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLI-IPENLKPTKIMSLIKSSD 974
Query: 1446 P-DAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGT 1504
NG++ FS+ + + G FEI + S G++F+++ LD E HY+ +V+ +D
Sbjct: 975 HLQQHYNGKLHFSIVADDKDGHFEI---DSSTGDLFLSKELDYETTSHYLFRVITTDHSK 1031
Query: 1505 PPRKKDHI-LQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIG-INSV 1562
+ L + + D ND+ P + +SV ENV GT V A D D +NS
Sbjct: 1032 NLSLSSTVFLSIDVEDQNDHSPSFQDEL-IVISVEENVPIGTLVYVFNAKDDDGSFLNSR 1090
Query: 1563 LSYYITEGNKDM-AFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEG---TPTLSATT 1618
+ YYI N F + G + T + DRE L T D+ T +
Sbjct: 1091 IQYYIESHNPGTNPFLIHPSFGTLVT-VSRLDRESIPTVILTVTASDQAVNVTDRRLRSL 1149
Query: 1619 HVYVTIVDENDNAPMFQQ-PHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAG 1677
+ I+D ND+ P F P+ V D T+ + + I A D DEG NG VTY+I++G
Sbjct: 1150 TAQIVILDVNDHNPTFISFPNAHVKEDV---TVGSLVHHITAHDPDEGRNGKVTYSILSG 1206
Query: 1678 NIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDI 1737
N TF +D G++T LDYE+ ++ D P LS T T TVL D+
Sbjct: 1207 NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQTLTVTVL----DV 1262
Query: 1738 NDNVPTFPRD-YEGPFEVTEGQ-PGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVIS 1795
ND P F + YE V E Q PG V A DRDSG N ++++ IM G F I+
Sbjct: 1263 NDEAPVFKQHLYEA--SVKENQNPGEFVTRVEALDRDSGVNSKLQFEIMPGASFELFEIN 1320
Query: 1796 PVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLP 1855
G V LDRE + L + RD G P LSST + V D ND+ P +
Sbjct: 1321 SDTG--EVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFIVSS 1378
Query: 1856 MNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLD 1915
+I + EN V VLASD D+G N + ++I GN + F IN +G ++ R LD
Sbjct: 1379 YDIEVLENQE-PEVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTRALD 1437
Query: 1916 RERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAG 1975
RE+I + L I D + PR + + ++ D ND+ P F YQ+ V E++ G
Sbjct: 1438 REQISNFTLVILCSDLGDPPRSSVIHLQVRVL---DANDHSPSFPTLYYQSSVREDAEVG 1494
Query: 1976 TPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPP 2035
T + VL+ A+D D+ + Y L SG F I+ +G T+++ +DREA S
Sbjct: 1495 TVVLVLS----AVDKDEGLNGQTEYFLTDEASGAFTIDPMSG--TLKTSNTLDREARSQH 1548
Query: 2036 ILELLLLAEDI-GLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT 2094
+ I G ++T + + + D NDN P V L P + + V A
Sbjct: 1549 TFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVRAD 1608
Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPL 2154
D D G NG +V+ A Q F I TG I+ E L + TD+G
Sbjct: 1609 DLDLGPNGTVVFSF-AETQSMFSIDKYTGEIQFQQNP--SSEYFPIWLQLKVTDQGIPAR 1665
Query: 2155 SGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD-LNPKLEYHIVG 2213
+ T ++ I ++ D + F + + V E+ E GT I + A D + ++Y I
Sbjct: 1666 TTTGLLVIHMEG-EDVKISFSHHLYKGLVTENCEAGTSIVTVKAFAPDSIQDSMKYSIFS 1724
Query: 2214 IVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVS 2273
N++ ++ +G + VK P + EV L V L E S
Sbjct: 1725 -----------GNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIV------LAESSGH 1767
Query: 2274 VPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTY 2333
K+ V + D NDN+P F+ + Y + E +I V A D D GLNGL+ Y
Sbjct: 1768 RAYCKVAVLIQDENDNSPCFEQ---SIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEY 1824
Query: 2334 TLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
++L Q+ D+ +G + +DYE + V+A+D G P + + +++
Sbjct: 1825 SILSGNQEEAFQI-DALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVT 1883
Query: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE-SKFAINP 2452
DINDN P F PS + ED G I+ V+ D D + + ++ +KFAI+
Sbjct: 1884 DINDNAPAF-LPSEAVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAIDQ 1942
Query: 2453 TTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKP 2512
TG + ++ +LD E+ Y L D+ +V++VLDVND P FS+
Sbjct: 1943 NTGVVVLVKTLDFEEMTEYELLIQISDSV-------HYTEGALVVRVLDVNDNPPVFSQD 1995
Query: 2513 QFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ 2572
+ +V E+ P G SV+T+ ATD + N ++Y + E F +D +G + T P+
Sbjct: 1996 FYQVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSKE-FSIDPKNGTIFTISPVL 2052
Query: 2573 SYEKFSLT---VVATDGGEPPLWGTTMLLVEVIDVNDNRPVF-VRPPNGTILHIREEIPL 2628
+ S T V A+DGG P L T++ + + D+N+ P F V+ N L + E+ +
Sbjct: 2053 LLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYN---LSLSEDALV 2109
Query: 2629 RSNVYEVYATDKD-EGLNGAVRYSFLKTAGNRDWEFFIIDPIS---------GLIQTAQR 2678
S + D D N V YS + +GN F + G +
Sbjct: 2110 GSTLVTFSNIDHDWTRENTYVEYSII--SGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS 2167
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
LDRE+ A + L+++ASD G P P + + + + D++DN P F S Y V
Sbjct: 2168 LDREASASHELVILASDSGCP-PLSSTAVISIQVLDVNDNPPNF-----SSLSYHT-HVK 2220
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREA 2797
E +P G+ + V A D D G +A + Y I +GNE+ +F+L+ + G L +++ LD E+
Sbjct: 2221 ESTPLGSHI-TVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKMT 2279
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
F+ V+AS + V V + D ND P+F + ++ V
Sbjct: 2280 KFTLTVQASDAEK--------------KHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPE 2325
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILA 2887
+ + S + + ALD D G + YSI++
Sbjct: 2326 NLPISSTICSINALDFDAGPYGELTYSIVS 2355
Score = 514 bits (1324), Expect = e-145
Identities = 493/1761 (27%), Positives = 807/1761 (45%), Gaps = 131/1761 (7%)
Query: 37 DTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPL 93
+ ++ + E PV VT + A+D D N + + VS E++S F ++ + G + L
Sbjct: 847 ELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSSEDSSDHFKIDANNGEIRTTTIL 906
Query: 94 DRETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGT 149
+ + + + +D QGV + VNIQV ++ + IPEN
Sbjct: 907 SYDYRPSYRMSVIATD-QGVPPLQGQAVVNIQVIPLSKGRAIMSQNIRHLIIPENLKPTK 965
Query: 150 PIFIVNATDP-DLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVN 206
+ ++ ++D G + +S + F IDS+ G + + +ELDYETT Y V
Sbjct: 966 IMSLIKSSDHLQQHYNGKLHFSIVADDKDGHFEIDSSTGDLFLSKELDYETTSHYLFRVI 1025
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
TD K LS+ L+I + D D P F + ++ E+ P GT V + A D D
Sbjct: 1026 TTDHSKNLSLSSTVFLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGS 1085
Query: 267 RPRG-IGYTIVSGNT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE----LN 320
I Y I S N + F + G L LDRE+ ILTV ++ +
Sbjct: 1086 FLNSRIQYYIESHNPGTNPFLIHPSFGTLVTVSRLDRES---IPTVILTVTASDQAVNVT 1142
Query: 321 DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENL 380
D R S T I+++D+ND+ P F S + + E VG +L I D DE
Sbjct: 1143 DRRLRS-----LTAQIVILDVNDHNPTFISFP-NAHVKEDVTVG-SLVHHITAHDPDEGR 1195
Query: 381 GLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPD 439
+ + L GN + F++ +S + PLDYE ++ + A ++ P
Sbjct: 1196 NGKVTYSI-LSGNENMTFMLDESSG------LLTTTCPLDYEMKTQHILTVLALDDGTPA 1248
Query: 440 HVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF 499
+ +T+++ ND P+F Q LY S+ EN G V V A D D+G ++ +
Sbjct: 1249 LSSSQTLTVTVLDVNDEAPVFKQHLYEASVKENQNPGEFVTRVEALDRDSGVNSKLQFEI 1308
Query: 500 SDDP--DRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVN 555
+ F ++ DTG ++ LD E+ + FTL ++ RDGG +T + V D N
Sbjct: 1309 MPGASFELFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDEN 1368
Query: 556 DNVPTFQKDAY-VGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISL 614
D+ P F +Y + L EP V V A+D D+ N + Y I+ + + ++
Sbjct: 1369 DHAPEFIVSSYDIEVLENQEPEVVYTV--LASDMDAGNNRAVEYHIIDGNTDECF---TI 1423
Query: 615 YEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKP 674
E G +S +R LD EQISN L ++ D G+PP +S + + + V D ND+ P+F
Sbjct: 1424 NEMSGELSTTRALDREQISN--FTLVILCSDLGDPPRSSVIHLQVRVLDANDHSPSFPTL 1481
Query: 675 AYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLL 734
Y SV E+ G VL L+A D D GQ + E S F I+ SG + T++ L
Sbjct: 1482 YYQSSVREDAEVGTVVLVLSAVDKDEGLN-GQTEYFLTDEASGAFTIDPMSGTLKTSNTL 1540
Query: 735 DRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD 794
DRE +S++ A D + ++ T + + + + D+NDN P + P+ + L +P +
Sbjct: 1541 DREARSQHTFSAVARDCSIQGSRSTTV-IIKVYVTDVNDNDPVLEQNPFDVFLSPESPTN 1599
Query: 795 SDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMR 854
V A D DLG NGT+V+S +S++ TG+I+ ++NP +
Sbjct: 1600 QTTVIVRADDLDLGPNGTVVFSFAETQSMFSIDKYTGEIQF------QQNPSSEYFPIW- 1652
Query: 855 KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVA 914
+ + VTD G P A ++ + V ++ D +F + + V E AG SI V A
Sbjct: 1653 -LQLKVTDQGIP---ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSIVTVKA 1708
Query: 915 IDLDEGLNGLVSYRMPVGMPRMDFLINSSSG--VVVTTTELDRERIAEYQLRVVASDAGT 972
D + + Y + G + S SG V LD E E QL V+A +G
Sbjct: 1709 FAPD-SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGH 1767
Query: 973 PTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSY 1032
+ L + D ND +P F ++Y SVSE V+ + TD D GLN + Y
Sbjct: 1768 RAYCKVAVL---IQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEY 1824
Query: 1033 FITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTV 1092
I GN + F + V+ T LD E T++Y LI++A D G R + T + V V
Sbjct: 1825 SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGM--PRLSNTTVIKVQV 1882
Query: 1093 LDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1152
D+NDN P FL S + ED G + + D D ++ N G F I
Sbjct: 1883 TDINDNAPAFLPSE-AVEITEDSLPGVIVTHVSVHDVDLNS-AFIFSFAKESNPGTKFAI 1940
Query: 1153 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1212
+ G+++ + LD E + + L+++ + + ++V V D+ND PVF+Q
Sbjct: 1941 DQNTGVVVL-VKTLDFEEMTEYELLIQISD---SVHYTEGALVVRVLDVNDNPPVFSQDF 1996
Query: 1213 YSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVN-YL 1271
Y ++ + E+ +G SV+ + ATD +S + ++YRILS ++ +F ID G I T++ L
Sbjct: 1997 Y-QVTVPESIPVGYSVLTLSATDLESNEN--ISYRILSSSK-EFSIDPKNGTIFTISPVL 2052
Query: 1272 DYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTE 1331
+T ++ V A+D P + V I + + + A +F+ SY ++ E+ +G+
Sbjct: 2053 LLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDALVGST 2112
Query: 1332 IVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA----------ITGVITVQGLVDREK 1381
+V D + TY + S ++ F ++ G + + +DRE
Sbjct: 2113 LVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHSLDREA 2172
Query: 1382 GDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440
+ L ++A D G P + ST + I VLD NDN P F S + E P+G +
Sbjct: 2173 SASHELVILASDSGCPPLSSTAVISIQVLDVNDNPPNFSSLS-YHTHVKESTPLGSHITV 2231
Query: 1441 VKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVAS 1500
V A D D GS+ ++++++ SGN G F + ++ G +++ +PLD E++ + L V AS
Sbjct: 2232 VSANDRDTGSHAEIIYNIISGNEKGHFYL---EENTGVLYLIKPLDYEKMTKFTLTVQAS 2288
Query: 1501 DRGTPPRKKDH----ILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRD 1556
D +K H ++ V++LD ND+ P ++ V EN+ + + + A D D
Sbjct: 2289 D-----AEKKHFSFAVVFVSVLDDNDHAPQFMFS-SFSCIVPENLPISSTICSINALDFD 2342
Query: 1557 IGINSVLSY------YITEG---NKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVE 1607
G L+Y ++T G + D+ F +D ++G+I + D E + Y L +
Sbjct: 2343 AGPYGELTYSIVSPCFLTHGMSYDHDL-FLIDPLTGDIHAKQI-LDYENGNKYCLTVQAK 2400
Query: 1608 DEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLI-TIQALDLDEGP 1666
D+G T S V + +DE + P+F Q Y L E + LI ++A D D G
Sbjct: 2401 DKGDATASLVVWVDIEGIDEFE--PIFTQDQYFFTLPE--KNKDRQLIGRVEASDADAGI 2456
Query: 1667 NGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTS 1726
+G + Y++ G F +++ G I + L S L T + I++H S
Sbjct: 2457 DGVILYSL--GTSSPFFSVNKTNGNIYLIRALPLIKSQ----LNKEDTLEMKIIAHSPKS 2510
Query: 1727 -----TTTVLVNVNDINDNVP 1742
+ TV VNV+ ++ P
Sbjct: 2511 DSKFASCTVFVNVSFSSEGTP 2531
Score = 464 bits (1194), Expect = e-130
Identities = 520/1942 (26%), Positives = 840/1942 (43%), Gaps = 251/1942 (12%)
Query: 1123 QLKATDADEGEFGRVWYRILHG----NHGNNFRIHVSNGLLMRGPRPLDRERN-SSHVLI 1177
++ A+DAD G +G + Y + G FRI +G + + +DRER+ +++ L+
Sbjct: 78 EVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVS-QDIDRERDPATYDLL 136
Query: 1178 VEAYNHD----------LGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTS 1227
VEA + D G + + V V +ED+ND PVF Y ET GT
Sbjct: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQP-GTE 195
Query: 1228 VIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSAT 1286
+I V ATD+DSG G V Y ++ G F ID +TGL Y + + V+ +
Sbjct: 196 IINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL--------YSPEVEILSAVNFS 247
Query: 1287 DQAPPFNQGFCSVYITLLNELDEAVQFSNAS---YEAA----ILENLALGTEIVRVQAYS 1339
N +++ LL + + A+ +EA+ + ++VQ +
Sbjct: 248 ADKEVMNS--LEMFLPLLRHFKKVERDEEAAEKKFEASRGWFMRFKGRRHLHYLKVQDEA 305
Query: 1340 IDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGP--- 1396
+ R Y + AK L + G+I + + + +L V A DGG
Sbjct: 306 ASADGEAAAR---YVANLAKILGE-----GIIYLTLPLSHLESTTLSLMVSAQDGGGLTA 357
Query: 1397 --KVDSTVKVYITVLDEND-NSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453
D T+ ++ T L + P++ F +PED P+G TVKA +P S+
Sbjct: 358 VINADVTIHIFQTTLAPAEFERPKYTFLVYE--DVPEDSPIG----TVKAREP-LNSSEP 410
Query: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
+ + ++SG++ G F I + +G + +PLD E +L V A G+ P +
Sbjct: 411 IFYRISSGDLGGKFSI---HPRLGTIRTRKPLDHETQPVVVLTVQAQ-LGSAPACSSTEV 466
Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
+T++D+NDN P + +++ GTA+ RA DRD G N ++ Y I
Sbjct: 467 NITVMDVNDNHPAFLRTSD-EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG 525
Query: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPM 1633
+ F +DR G + + E++ L ED+G +A V ++++ +++P
Sbjct: 526 V-FAIDRALGVLFLNGSLGAGEQRELT-LTLRAEDQGVHPQAALL-VLTVVIEKREHSPS 582
Query: 1634 FQQPH--YEVLLDEGPDTLNTSLITIQALDLDEGPNGTVT---YAIVAGNIVNTFRIDRH 1688
+ H Y+V + E + T ++ QA L GP + Y++ F I +
Sbjct: 583 WTFEHLVYQVEVSESLSPM-TQMLQTQAHPL--GPQRAASPLRYSLEPSVDSAMFGIRPY 639
Query: 1689 MGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDY 1748
G I ++ DYE S Y V A P +TTV+V V D NDN PTF D
Sbjct: 640 TGWIYLRRQFDYE-STQTYNFRVFAW--IPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV 696
Query: 1749 EGPFEVTEGQPGPR--VWTFLAHDRDSGPNGQVEYSIM-DGD---------PLG------ 1790
F E P P+ + A D DSG NGQ+ Y ++ DG P G
Sbjct: 697 L--FLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLLSDGKFFKMNPNTGPAGTIYVIT 754
Query: 1791 -----------EFVISPVEGVLRVRKD-------------VELDRETIAFYNLTICARDR 1826
+F S E V K V LDRE + +T+ DR
Sbjct: 755 WADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGELINWVALDREHRGHHEMTVLVTDR 814
Query: 1827 GMPPLSSTMLVGIRVLDINDNDPV----LLNLPMNITISENSPVSSFVAHVLASDADSGC 1882
G PP ++TM V + V DINDN P L +++ + E PV+ V V A D D G
Sbjct: 815 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 874
Query: 1883 NARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDY 1942
NA +T+++++ + F I+A G + L + P Y++++ D P +
Sbjct: 875 NAEVTYSVSSEDSSDHFKIDANNGEIRTTTILSYDYRPSYRMSVIATDQGVPPLQGQAVV 934
Query: 1943 DLLLIFLS------DENDNHPLFTKSTYQAEVMENSPAGTPLTV-LNGPI-LALDADQDI 1994
++ +I LS +N H + ++ ++M + L NG + ++ AD
Sbjct: 935 NIQVIPLSKGRAIMSQNIRHLIIPENLKPTKIMSLIKSSDHLQQHYNGKLHFSIVADD-- 992
Query: 1995 YAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL-LNSTA 2053
+ G F+I+SSTG + + +D E S + ++ L L+ST
Sbjct: 993 -----------KDGHFEIDSSTGDLFLSKE--LDYETTSHYLFRVITTDHSKNLSLSSTV 1039
Query: 2054 HLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDED-SGLNGELVYRIEAG- 2111
L I + D ND+ P+F + + + EN P G V A D+D S LN + Y IE+
Sbjct: 1040 FLSIDVEDQNDHSPSFQDELIVISVEENVPIGTLVYVFNAKDDDGSFLNSRIQYYIESHN 1099
Query: 2112 -AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRG---TVPLSGTAIVTILIDDI 2167
+ FLIH G + V + +DRE + LTV A+D+ T + I+I D+
Sbjct: 1100 PGTNPFLIHPSFGTL-VTVSRLDRESIPTVILTVTASDQAVNVTDRRLRSLTAQIVILDV 1158
Query: 2168 NDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVP 2225
ND P F++ V E G+++ +ITA D D N K+ Y I L
Sbjct: 1159 NDHNPTFIS-FPNAHVKEDVTVGSLVHHITAHDPDEGRNGKVTYSI-----------LSG 1206
Query: 2226 NQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLD 2285
N+ F ++ ++G + P++ E+ + +T+ +D+ + S + LTV VLD
Sbjct: 1207 NENMTFMLDESSGLLTTTCPLDYEMKTQHILTVLALDDGTPALSSSQT-----LTVTVLD 1261
Query: 2286 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2345
VND P FK Y + E PG + V A+D D G+N + + +++P +
Sbjct: 1262 VNDEAPVFKQH---LYEASVKENQNPGEFVTRVEALDRDSGVNSKLQF---EIMPGASFE 1315
Query: 2346 LED--SSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFD 2403
L + S G+V+ +D E V D G P ++ + + D ND+ P F
Sbjct: 1316 LFEINSDTGEVVTTTILDREIQEVFTLRVLVRDGGFPSLSSTTTILCTVEDENDHAPEFI 1375
Query: 2404 QPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLS 2461
SY V E+ ++ TV A+D D+GN +EY + DG + F IN +G++
Sbjct: 1376 VSSYDIEVLENQEP-EVVYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSGELSTTR 1434
Query: 2462 SLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYEN 2521
+LDRE+ ++ L L D + R + + + ++VLD ND P F + +SV E+
Sbjct: 1435 ALDREQISNFTLVILCSD----LGDPPRSSVIHLQVRVLDANDHSPSFPTLYYQSSVRED 1490
Query: 2522 EPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSL 2579
GT V+ + A D+DEG NG+ Y L AF +D SG + T L ++ + +
Sbjct: 1491 AEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARSQHTF 1550
Query: 2580 TVVATDGGEPPLWGTTMLL-VEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYAT 2638
+ VA D TT+++ V V DVNDN PV + P L E P V A
Sbjct: 1551 SAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLS--PESPTNQTTVIVRAD 1608
Query: 2639 DKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQ 2698
D D G NG V +SF +T F ID +G IQ Q E ++ + V Q
Sbjct: 1609 DLDLGPNGTVVFSFAETQS-----MFSIDKYTGEIQFQQNPSSEYFPIWLQLKVTD---Q 1660
Query: 2699 PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADE 2758
+P T L V + +D + F S V E+ GT + VT A +
Sbjct: 1661 GIPARTTTGLLVIHMEGEDVKISF------SHHLYKGLVTENCEAGTSI--VTVKAFAPD 1712
Query: 2759 GPNAIVYYFIAAGNEEKNFHLQPDGCLLVLR-----DLDREREAIFSFIVKASSNRSWTP 2813
+ Y I +GNE+ L L ++ D + E + ++S +R++
Sbjct: 1713 SIQDSMKYSIFSGNEDGVLSLCSKSGQLTVKEPKFLDFEVRNEVQLIVLAESSGHRAYC- 1771
Query: 2814 PRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDA 2873
+V V+++D ND P F ++ Y A V+ + +IQV A D
Sbjct: 1772 -----------------KVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDL 1814
Query: 2874 DIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRT-----FDLFMAYSPGYF 2928
D G N L+ YSIL S + + F + ++ G++ T ++L +YS
Sbjct: 1815 DSGLNGLIEYSIL-----------SGNQEEAFQIDALSGVITTKAILDYELTSSYS---L 1860
Query: 2929 VVDIVARDLAGHNDTAIIGIYI 2950
+V + + ++T +I + +
Sbjct: 1861 IVQATDKGMPRLSNTTVIKVQV 1882
Score = 342 bits (878), Expect = 3e-93
Identities = 329/1167 (28%), Positives = 525/1167 (44%), Gaps = 98/1167 (8%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTG 85
P F +D +L +++ V V +LA DMD N + + + F + +G
Sbjct: 1372 PEFIVSSYDIEVLENQEPEV---VYTVLASDMDAGNNRAVEYHIIDGNTDECFTINEMSG 1428
Query: 86 VVWLRQPLDRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVR 140
+ + LDRE S FT+ SD VI + ++V D ND++P+F Y
Sbjct: 1429 ELSTTRALDREQISNFTLVILCSDLGDPPRSSVI--HLQVRVLDANDHSPSFPTLYYQSS 1486
Query: 141 IPENTPVGTPIFIVNATDPDLGAGGSVLYSF-QPPSQFFAIDSARGIVTVIRELDYETTQ 199
+ E+ VGT + +++A D D G G Y S F ID G + LD E
Sbjct: 1487 VREDAEVGTVVLVLSAVDKDEGLNGQTEYFLTDEASGAFTIDPMSGTLKTSNTLDREARS 1546
Query: 200 AYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIIT 259
+ + A D ST + + +TDV D DP+ P+ + SP T I+
Sbjct: 1547 QHTFSAVARDCSIQGSRSTTVIIKVYVTDVNDNDPVLEQNPFDVFLSPESPTNQTTVIVR 1606
Query: 260 AIDQDKGRPRGIGYTIV--SGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
A D D G P G T+V T S+F++D +G + ++NP S +
Sbjct: 1607 ADDLDLG-PNG---TVVFSFAETQSMFSIDKYTGEIQF-----QQNP--SSEYFPIWLQL 1655
Query: 318 ELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD 377
++ D P A TT ++ ++ D F+ Y +TE + G ++ + V
Sbjct: 1656 KVTDQGIP--ARTTTGLLVIHMEGEDVKISFSHHLYKGLVTENCEAGTSI---VTVKAFA 1710
Query: 378 ENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESV 437
+ +SM Y + + + ++S S G+ + ++ LD+E + + A S
Sbjct: 1711 PDSIQDSM--KYSIFSGNEDGVLSLCSKSGQ--LTVKEPKFLDFEVRNEVQLIVLAESS- 1765
Query: 438 PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFG--EV 495
H Y KV + + +ENDN P F Q +Y S+ E+ V+ V ATD D+G G E
Sbjct: 1766 -GHRAYCKVAVLIQDENDNSPCFEQSIYQASVSESQLYNAHVIQVFATDLDSGLNGLIEY 1824
Query: 496 SYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLD 553
S + + F +D +G+I A LDYEL ++L + A D G T +++ V D
Sbjct: 1825 SILSGNQEEAFQIDALSGVITTKAILDYELTSSYSLIVQATDKGMPRLSNTTVIKVQVTD 1884
Query: 554 VNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDIS 613
+NDN P F A+ E S+ ++ + D N+ +S S G+ F I
Sbjct: 1885 INDNAPAFLPSE---AVEITEDSLPGVIVTHVSVHDVDLNSAFIFSFAKESNPGTKFAID 1941
Query: 614 LYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSK 673
+ GV+ + + LD+E+++ L + D+ + + V + V D NDNPP FS+
Sbjct: 1942 --QNTGVVVLVKTLDFEEMTE--YELLIQISDSVHYTEGALV---VRVLDVNDNPPVFSQ 1994
Query: 674 PAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYS-LEGSTQFRINARSGEITTTS 732
Y V+V E+I G +VL L+ATDL+ E+I Y L S +F I+ ++G I T S
Sbjct: 1995 DFYQVTVPESIPVGYSVLTLSATDLE-----SNENISYRILSSSKEFSIDPKNGTIFTIS 2049
Query: 733 -LLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
+L +T S +V A DG G+ + V I + D+N+ P + Y ++L E
Sbjct: 2050 PVLLLDTISTTQFLVEASDG--GNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSEDA 2107
Query: 792 PPDSDVTTVVAVDPDLGENGTLV-YSIQPPN---------KFYSLN---STTGKIRTTHA 838
S + T +D D T V YSI N KF+ G + H+
Sbjct: 2108 LVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLLHS 2167
Query: 839 MLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAE 898
LDRE HE +V+ +D G PPL +S+A + + +LD+NDN P F +L +
Sbjct: 2168 -LDREASASHE------LVILASDSGCPPL--SSTAVISIQVLDVNDNPPNFSSLSYHTH 2218
Query: 899 VLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERI 958
V E P G I V A D D G + + Y + G + F + ++GV+ LD E++
Sbjct: 2219 VKESTPLGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEKM 2278
Query: 959 AEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLN 1018
++ L V ASDA S + + + VLD ND P F + ++ V E++P + +N
Sbjct: 2279 TKFTLTVQASDA-EKKHFSFAVVFVSVLDDNDHAPQFMFSSFSCIVPENLPISSTICSIN 2337
Query: 1019 CTDNDVGLNAELSY------FITGGNV--DGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
D D G EL+Y F+T G F + + LD E Y L +
Sbjct: 2338 ALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLTGDIHAKQILDYENGNKYCLTV 2397
Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
+A D G T + V+V + +++ PIF Q Y ++PE + I +++A+DAD
Sbjct: 2398 QAKDKGDA----TASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVEASDAD 2453
Query: 1131 EGEFGRVWYRILHGNHGNNFRIHVSNG 1157
G G + Y + G F ++ +NG
Sbjct: 2454 AGIDGVILYSL--GTSSPFFSVNKTNG 2478
Score = 156 bits (395), Expect = 3e-37
Identities = 231/923 (25%), Positives = 357/923 (38%), Gaps = 135/923 (14%)
Query: 2080 ENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-----AQDRFLIHLVTGVIRVGNATIDR 2134
EN P +VTA+D DSGL G + Y + G A F I G I V IDR
Sbjct: 69 ENAKP-VKETEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQ-DIDR 126
Query: 2135 EEQ-------------ESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
E + R+T +A +G LS A V + ++D+ND+ P F
Sbjct: 127 ERDPATYDLLVEAKDGDEQRMTHLALVKGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVT 184
Query: 2182 SVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVP-NQEDAFAVNINTG-- 2238
S+ + +PGT I N+ A D D I G VA + L+P N F ++ TG
Sbjct: 185 SISDETQPGTEIINVLATDQDSG------IYGTVAYE----LIPGNVSSLFTIDSTTGLY 234
Query: 2239 --SVMVKSPMN----RELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292
V + S +N +E++ + E+ L ++ + + ER K + +
Sbjct: 235 SPEVEILSAVNFSADKEVMNSLEMFLPLLRHFKKV-ERDEEAAEKKFEAS----RGWFMR 289
Query: 2293 FKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAG 2352
FK +Y++ E A+ A + K L + Y L L
Sbjct: 290 FKGRRHLHYLKVQDEAASADGEAAARYVANLAKILGEGIIYLTLPL-------------- 335
Query: 2353 KVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVF 2412
+ E L+ V A D G V + I F++P Y V+
Sbjct: 336 --------SHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFLVY 387
Query: 2413 EDVPVGTIILTVTATD-ADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHY 2471
EDVP + I TV A + +S S GD KF+I+P G I LD E +
Sbjct: 388 EDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQPVV 447
Query: 2472 ILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITM 2531
+LT A+ S S +V I V+DVND P F + + + P GT++
Sbjct: 448 VLTVQAQLGSAPACS-----STEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLA 502
Query: 2532 MATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYE--KFSLTVVATDGGEP 2589
A D+D G NG + YS+ P F +D G++ L + E + +LT+ A D G
Sbjct: 503 RAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH 562
Query: 2590 PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD-KDEGLNGAV 2648
P ++L VI+ ++ P + + + E + + + + A + +
Sbjct: 563 P-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPL 621
Query: 2649 RYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPL 2708
RYS + D F I P +G I ++ D ES Y+ + A +
Sbjct: 622 RYSLEPSV---DSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVSTTV 678
Query: 2709 QVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFI 2768
V + D +DN P F+ L V E ++G +T A+D D G N + YF+
Sbjct: 679 IVRVWDENDNSPTFLH------DVLFLKVEESPVPQGVIGKIT-AIDMDSGKNGQLLYFL 731
Query: 2769 AAGNE--EKNFHLQPDGCLLVL-----------RDLDREREAIFSFIVKA-------SSN 2808
+ + + N + P G + V+ D + + +F++K+
Sbjct: 732 LSDGKFFKMNPNTGPAGTIYVITWADGAAAFSGTDFAFSSDELQAFVLKSLFCELGEGEL 791
Query: 2809 RSWT----PPRGPSPTLDLVADL------TLQEVRVVLEDINDQPPRFTKA----EYTAG 2854
+W RG LV D V V + DIND P F + E
Sbjct: 792 INWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVK 851
Query: 2855 VATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGIL 2914
V V + V A D D GNN+ V YS+ SED F + + +G +
Sbjct: 852 VLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV-----------SSEDSSDHFKIDANNGEI 900
Query: 2915 RTFD-LFMAYSPGYFVVDIVARD 2936
RT L Y P Y + ++A D
Sbjct: 901 RTTTILSYDYRPSY-RMSVIATD 922
Score = 142 bits (358), Expect = 6e-33
Identities = 141/518 (27%), Positives = 239/518 (46%), Gaps = 46/518 (8%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTGVV 87
P F+ F+ + + E PVG SV L A D++ N+ + + + +S+ F+++P G +
Sbjct: 1990 PVFSQDFYQ--VTVPESIPVGYSVLTLSATDLESNENISYRILS--SSKEFSIDPKNGTI 2045
Query: 88 WLRQP---LDRETKSEFTVEFSVSDHQGV-ITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143
+ P LD + ++F VE S + + V I + D+N+ AP F + Y++ + E
Sbjct: 2046 FTISPVLLLDTISTTQFLVEASDGGNPDLRALTLVEIGIEDMNNYAPEFTVKSYNLSLSE 2105
Query: 144 NTPVGTPIFIVNATDPDLGA----------GGSVLYSFQPPSQFFAID---SARGIVTVI 190
+ VG+ + + D D G+ +F ++FF + G + ++
Sbjct: 2106 DALVGSTLVTFSNIDHDWTRENTYVEYSIISGNSQNNFHVETKFFHSEYPYKQVGYLVLL 2165
Query: 191 RELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSP 250
LD E + +++L + A+D PLS+ A ++I + DV D P F +L Y T++ E +P
Sbjct: 2166 HSLDREASASHELVILASDSG-CPPLSSTAVISIQVLDVNDNPPNFSSLSYHTHVKESTP 2224
Query: 251 PGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGF 310
G+ + +++A D+D G I Y I+SGN F L+ +GVL L LD E F
Sbjct: 2225 LGSHITVVSANDRDTGSHAEIIYNIISGNEKGHFYLEENTGVLYLIKPLDYEK---MTKF 2281
Query: 311 ILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLF 370
LTV+ + D + F + V+D ND+AP+F S +S + E + +
Sbjct: 2282 TLTVQAS----DAEKKHFSFAVVF-VSVLDDNDHAPQFMFSSFSCIVPENLPISSTI-CS 2335
Query: 371 IQVVDKDE----NLGLNSMFEVYLVGNNSHH---FIISPTSVQGKADIRIRVAIPLDYET 423
I +D D L + + +L S+ F+I P + DI + LDYE
Sbjct: 2336 INALDFDAGPYGELTYSIVSPCFLTHGMSYDHDLFLIDPLT----GDIHAKQI--LDYEN 2389
Query: 424 VDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL 483
++Y + A + D V + + ++ PIF+Q Y +L E + V
Sbjct: 2390 GNKYCLTVQAKDK-GDATASLVVWVDIEGIDEFEPIFTQDQYFFTLPEKNKDRQLIGRVE 2448
Query: 484 ATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARL 521
A+D DAG G + Y FS++K G I LI L
Sbjct: 2449 ASDADAGIDGVILYSLGTSSPFFSVNKTNGNIYLIRAL 2486
Score = 72.4 bits (176), Expect = 7e-12
Identities = 51/156 (32%), Positives = 77/156 (49%), Gaps = 18/156 (11%)
Query: 154 VNATDPDLGAGGSVLYS-------FQPPSQFFAIDSARGIVTVIRELDYETTQA-YQLTV 205
V A+D D G G + YS ++ P Q F ID G + V +++D E A Y L V
Sbjct: 79 VTASDADSGLYGFIEYSLYDGFLSYEAP-QAFRIDPHDGQICVSQDIDRERDPATYDLLV 137
Query: 206 NATDQDKTRP---------LSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVR 256
A D D+ R LS A + + + DV D P+F Y T+I + + PGT +
Sbjct: 138 EAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 197
Query: 257 IITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGV 292
+ A DQD G + Y ++ GN +S+F +D +G+
Sbjct: 198 NVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233
Score = 61.6 bits (148), Expect = 1e-08
Identities = 50/157 (31%), Positives = 69/157 (43%), Gaps = 23/157 (14%)
Query: 53 TQLLAQDMDNDPLVF-------GVSGEEASRFFAVEPDTGVVWLRQPLDRETKS---EFT 102
T++ A D D+ F G EA + F ++P G + + Q +DRE +
Sbjct: 77 TEVTASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLL 136
Query: 103 VEFSVSDHQ---------GVITRK--VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
VE D Q G ++ + V + + DVNDN P F+ Y I + T GT I
Sbjct: 137 VEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEI 196
Query: 152 FIVNATDPDLGAGGSVLYSFQP--PSQFFAIDSARGI 186
V ATD D G G+V Y P S F IDS G+
Sbjct: 197 INVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGL 233
Score = 60.1 bits (144), Expect = 4e-08
Identities = 59/200 (29%), Positives = 90/200 (45%), Gaps = 30/200 (15%)
Query: 2727 KGSPQYQL-----LTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAG----NEEKNF 2777
+GSP+ +L E + + VT A DAD G + Y + G + F
Sbjct: 51 RGSPETELWGAIVFRSQEENAKPVKETEVT-ASDADSGLYGFIEYSLYDGFLSYEAPQAF 109
Query: 2778 HLQP-DGCLLVLRDLDRERE-AIFSFIVKASSNRSWTPPRGPSPTLDLV-ADLTLQE-VR 2833
+ P DG + V +D+DRER+ A + +V+A L LV L+ Q VR
Sbjct: 110 RIDPHDGQICVSQDIDRERDPATYDLLVEAKDGDEQRMTH-----LALVKGGLSAQAFVR 164
Query: 2834 VVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRA 2893
V LED+ND P F + Y ++ + + G+E+I VLA D D G V Y ++
Sbjct: 165 VDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI------- 217
Query: 2894 LANDSEDVGQVFTMGSMDGI 2913
+V +FT+ S G+
Sbjct: 218 ----PGNVSSLFTIDSTTGL 233
Score = 40.0 bits (92), Expect = 0.039
Identities = 44/173 (25%), Positives = 76/173 (43%), Gaps = 35/173 (20%)
Query: 584 RATDEDSPP--NNQITYSIVSASAFGSYFDISLYEGY---------------GVISVSRP 626
R+ +E++ P ++T S + +G + + SLY+G+ G I VS+
Sbjct: 65 RSQEENAKPVKETEVTASDADSGLYG-FIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQD 123
Query: 627 LDYEQISNGLIYLTVMAMDAGNPP----------LNSTVPVTIEVFDENDNPPTFSKPAY 676
+D E+ L V A D L++ V +++ D NDN P F+ Y
Sbjct: 124 IDRER-DPATYDLLVEAKDGDEQRMTHLALVKGGLSAQAFVRVDLEDVNDNHPVFNPSTY 182
Query: 677 FVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL---EGSTQFRINARSG 726
S+ + G ++ + ATD D S YG ++ Y L S+ F I++ +G
Sbjct: 183 VTSISDETQPGTEIINVLATDQD-SGIYG--TVAYELIPGNVSSLFTIDSTTG 232
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 444 bits (1142), Expect = e-124
Identities = 341/980 (34%), Positives = 487/980 (49%), Gaps = 53/980 (5%)
Query: 1100 PIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI--LHGNHGNNF-RIHVSN 1156
P F SY+A+VPE+ P G + L+A D DEGE GR+ Y + L + N F +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 1157 GLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVI-VYVEDINDEAPVFTQQQYSR 1215
G + LDRE S+HV V A +H + P RS++ + + V D ND PVF QQ+Y
Sbjct: 239 GAVTTAEE-LDRETKSTHVFRVTAQDHGM-PRRSALATLTILVTDTNDHDPVFEQQEYKE 296
Query: 1216 LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK----FEIDESTGLIITVNYL 1271
LRE +G V+ V+ATD D+ + YR+L G+ G FEID +G+I T +
Sbjct: 297 -SLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPV 355
Query: 1272 DYETKTSYMMNVSATDQA--PPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALG 1329
D E SY + V A+DQ P +V++++ ++ D A QFS Y + E++ G
Sbjct: 356 DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPG 415
Query: 1330 TEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV 1389
++RV A D + ++ S A+ F +DA TG + V +D E YTL V
Sbjct: 416 APVLRVTASDRDKGSNAVVHYSIM-SGNARGQFYLDAQTGALDVVSPLDYETTKEYTLRV 474
Query: 1390 VADDGGPKVDSTVKVYITV--LDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPD 1447
A DGG S V +TV LD NDN+P F T A ++ E P+G V V+A D D
Sbjct: 475 RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQA-TVLESVPLGYLVLHVQAIDAD 533
Query: 1448 AGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPR 1507
AG N ++ + LA F T N+ G + VA LDREE+D Y V A D GTP
Sbjct: 534 AGDNARLEYRLAGVGHDFPF---TINNGTGWISVAAELDREEVDFYSFGVEARDHGTPAL 590
Query: 1508 KKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYI 1567
+ VT+LD+NDN P P Y V +NE+ GT+VV V A DRD +SV++Y I
Sbjct: 591 TASASVSVTVLDVNDNNPTFTQP-EYTVRLNEDAAVGTSVVTVSAVDRDA--HSVITYQI 647
Query: 1568 TEGNKDMAFRMDRISGE-IATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVD 1626
T GN F + SG + + P D + + Y L T D T T + V + D
Sbjct: 648 TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG---TRQDTAQIVVNVTD 704
Query: 1627 ENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRID 1686
N + P+FQ HY V ++E T+++ I A D D G N +TY + + + FRID
Sbjct: 705 ANTHRPVFQSSHYTVNVNEDRPA-GTTVVLISATDEDTGENARITYFME--DSIPQFRID 761
Query: 1687 RHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPR 1746
G +T ELDYE YTL +TA D + + TT + + VND+NDN P F R
Sbjct: 762 ADTGAVTTQAELDYE-DQVSYTLAITARDNG---IPQKSDTTYLEILVNDVNDNAPQFLR 817
Query: 1747 D-YEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPL-GEFVISPVEGVLRVR 1804
D Y+G + P V A DRDSG NG+V Y+ GD G+F++ G++R
Sbjct: 818 DSYQGSV-YEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL 876
Query: 1805 KDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENS 1864
+ LDRE +A Y L A D+GMPP + M V + VLD+NDN PV ++ + ENS
Sbjct: 877 R--RLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENS 934
Query: 1865 PVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKL 1924
P+ VA V A+D D G NA++ + I GN F ++ +G +T LD E PEY L
Sbjct: 935 PIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTALVDLDYEDRPEYVL 994
Query: 1925 TISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGP 1984
I P R + + L D NDN P+ + N + G
Sbjct: 995 VIQATSAPLVSRAT------VHVRLLDRNDNPPVLGNFEI---LFNNYVTNRSSSFPGGA 1045
Query: 1985 ILALDA-DQDIYAVVTYQL-LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLL 2042
I + A D DI +TY G + L +N+STG + + + +R + +L+
Sbjct: 1046 IGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPL---EAIMSVLV 1102
Query: 2043 AEDIGLLNSTAHLLITILDD 2062
++ + + + L +TI+ D
Sbjct: 1103 SDGVHSVTAQCALRVTIITD 1122
Score = 405 bits (1041), Expect = e-112
Identities = 312/908 (34%), Positives = 457/908 (50%), Gaps = 85/908 (9%)
Query: 1957 PLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQ---LLGAQSG-LFDI 2012
P F +YQA V EN PAGTP+ L A+D D+ + Y L ++S F +
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLR----AIDPDEGEAGRLEYTMDALFDSRSNQFFSL 234
Query: 2013 NSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITIL--DDNDNRPTFS 2070
+ TG VT +DRE S + + A+D G+ +A +TIL D ND+ P F
Sbjct: 235 DPVTGAVTTAEE--LDRETKSTHVFRVT--AQDHGMPRRSALATLTILVTDTNDHDPVFE 290
Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGA----QDRFLIHLVTGVIR 2126
L EN G+ VL V ATD D+ N ++YR+ G+ + F I +GVIR
Sbjct: 291 QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIR 350
Query: 2127 VGNATIDREEQESYRLTVVATDRGTVP--LSGTAIVTILIDDINDSRPEFLNPIQTVSVL 2184
+DREE ESY+LTV A+D+G P S TA V + ++D ND+ P+F V V
Sbjct: 351 T-RGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
Query: 2185 ESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV 2242
E PG + +TA D D N + Y I+ N F ++ TG++ V
Sbjct: 410 EDVTPGAPVLRVTASDRDKGSNAVVHYSIMS-----------GNARGQFYLDAQTGALDV 458
Query: 2243 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYM 2302
SP++ E T E TL V A D +S + +TV VLD+NDN P F T +
Sbjct: 459 VSPLDYE--TTKEYTLRV--RAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVS---TPFQ 511
Query: 2303 ERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDY 2362
+LE G ++ V A+D D G N + Y L V + ++ G + +D
Sbjct: 512 ATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAG-VGHDFPFTINNGTGWISVAAELDR 570
Query: 2363 EEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIIL 2422
EEV + +F V A D+G+P A V + ++D+NDNNP F QP Y + ED VGT ++
Sbjct: 571 EEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVV 630
Query: 2423 TVTATDADSGNFALIEYSLGDGESKFAINPTTGD--IYVLSSLDREKKDHYILTALAKDN 2480
TV+A D D+ + + + G+ ++F+I +G + + LD + + Y+L A D
Sbjct: 631 TVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD- 689
Query: 2481 PGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2540
R+++ Q+V+ V D N RP F ++ +V E+ PAGT+V+ + ATD+D G
Sbjct: 690 ------GTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGE 743
Query: 2541 NGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLL 2598
N +TY +E + F +D D+G VTTQ L + ++L + A D G P TT L
Sbjct: 744 NARITYFME-DSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLE 802
Query: 2599 VEVIDVNDNRPVFVRPP-NGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAG 2657
+ V DVNDN P F+R G++ E++P ++V ++ ATD+D GLNG V Y+F G
Sbjct: 803 ILVNDVNDNAPQFLRDSYQGSVY---EDVPPFTSVLQISATDRDSGLNGRVFYTF--QGG 857
Query: 2658 NRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDD 2717
+ FI++ SG+++T +RLDRE+ A Y L A D G P P T + V + D++D
Sbjct: 858 DDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMP-PARTPMEVTVTVLDVND 916
Query: 2718 NEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNF 2777
N P+F + ++ + V E+SP G V VT A D DEG NA + Y I GN + F
Sbjct: 917 NPPVFEQ-----DEFDVF-VEENSPIGLAVARVT-ATDPDEGTNAQIMYQIVEGNIPEVF 969
Query: 2778 HLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVL 2836
L G L L DLD E + +++A+S LV+ T V V L
Sbjct: 970 QLDIFSGELTALVDLDYEDRPEYVLVIQATS-------------APLVSRAT---VHVRL 1013
Query: 2837 EDINDQPP 2844
D ND PP
Sbjct: 1014 LDRNDNPP 1021
Score = 392 bits (1007), Expect = e-108
Identities = 304/974 (31%), Positives = 462/974 (47%), Gaps = 62/974 (6%)
Query: 1530 PFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT---EGNKDMAFRMDRISGEIA 1586
P Y +V EN GT V +RA D D G L Y + + + F +D ++G +
Sbjct: 183 PPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVT 242
Query: 1587 TRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEG 1646
T DRE +S + T +D G P SA + + + D ND+ P+F+Q Y+ L E
Sbjct: 243 TAEEL-DRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKESLREN 301
Query: 1647 PDTLNTSLITIQALDLDEGPNGTVTYAIV---AGNIVNTFRIDRHMGVITAAKELDYEIS 1703
+ + ++T++A D D PN + Y ++ G+ F ID GVI +D E
Sbjct: 302 LE-VGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEV 360
Query: 1704 HGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRV 1763
Y L V A+DQ R T T V ++V D NDN P F + PG V
Sbjct: 361 ES-YQLTVEASDQGRDPGPRST-TAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPV 418
Query: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823
A DRD G N V YSIM G+ G+F + G L V LD ET Y L + A
Sbjct: 419 LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP--LDYETTKEYTLRVRA 476
Query: 1824 RDRGMPPLSSTM-LVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGC 1882
+D G PPLS+ LV ++VLDINDN P+ ++ P T+ E+ P+ V HV A DAD+G
Sbjct: 477 QDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHVQAIDADAGD 536
Query: 1883 NARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDY 1942
NARL + + + F IN TG ++V LDRE + Y + +D+ A
Sbjct: 537 NARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPALTASASV 596
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL 2002
+ ++ D NDN+P FT+ Y + E++ GT + ++ D+D ++V+TYQ+
Sbjct: 597 SVTVL---DVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSA------VDRDAHSVITYQI 647
Query: 2003 L-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILD 2061
G F I S +G V + +D + +L + A D G TA +++ + D
Sbjct: 648 TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVT--ASD-GTRQDTAQIVVNVTD 704
Query: 2062 DNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLV 2121
N +RP F + TV++ E+ P G +V+ ++ATDED+G N + Y +E +F I
Sbjct: 705 ANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMEDSIP-QFRIDAD 763
Query: 2122 TGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
TG + A +D E+Q SY L + A D G S T + IL++D+ND+ P+FL
Sbjct: 764 TGAVTT-QAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQG 822
Query: 2182 SVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
SV E P T + I+A D D LN ++ Y G DD D F V +G
Sbjct: 823 SVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQG---GDDGD-------GDFIVESTSGI 872
Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
V ++RE VA Y + +D P R+ ++TV VLDVNDN P F+
Sbjct: 873 VRTLRRLDRENVAQYVLRAYAVDKGMP-PARTPM----EVTVTVLDVNDNPPVFEQDEFD 927
Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 2359
++E E + G + V A DPD+G N + Y +++ P QL D +G++ A
Sbjct: 928 VFVE---ENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQL-DIFSGELTALVD 983
Query: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPV-- 2417
+DYE+ ++A+ S P + V++ ++D NDN P+ E +F +
Sbjct: 984 LDYEDRPEYVLVIQAT---SAPLVSRATVHVRLLDRNDNPPVLGN---FEILFNNYVTNR 1037
Query: 2418 -----GTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYI 2472
G I V A D D + + G+ S +N +TG++ + +LD + I
Sbjct: 1038 SSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAI 1097
Query: 2473 LTALAKDNPGDVAS 2486
++ L D V +
Sbjct: 1098 MSVLVSDGVHSVTA 1111
Score = 390 bits (1001), Expect = e-107
Identities = 316/996 (31%), Positives = 469/996 (47%), Gaps = 58/996 (5%)
Query: 541 EETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI 600
E GR + NV + P FQ +Y + EN+P+ T + LRA D D ++ Y++
Sbjct: 165 ESLGGRRKRNV----NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM 220
Query: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
+ S SL G ++ + LD E S + +T A D G P ++ +TI
Sbjct: 221 DALFDSRSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVT--AQDHGMPRRSALATLTIL 278
Query: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGS--- 716
V D ND+ P F + Y S+ EN+ G VL + ATD D +I+Y L EGS
Sbjct: 279 VTDTNDHDPVFEQQEYKESLRENLEVGYEVLTVRATDGDAPPN---ANILYRLLEGSGGS 335
Query: 717 --TQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDN 774
F I+ RSG I T +DRE Y L V A D G ++ A V +++ D NDN
Sbjct: 336 PSEVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDN 395
Query: 775 HPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN---KFYSLNSTTG 831
P + + Y + + E P + V V A D D G N + YSI N +FY L++ TG
Sbjct: 396 APQFSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFY-LDAQTG 454
Query: 832 KIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ 891
LD +P +E + V D GRPPL + S V V +LD+NDN P F
Sbjct: 455 A-------LDVVSPLDYETTKEYTLRVRAQDGGRPPL-SNVSGLVTVQVLDINDNAPIFV 506
Query: 892 NLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTT 951
+ PF A VLE +P G + V AID D G N + YR+ F IN+ +G +
Sbjct: 507 STPFQATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAA 566
Query: 952 ELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPRE 1011
ELDRE + Y V A D GTP ++++++++ VLDVND PTF Y V ++ED
Sbjct: 567 ELDREEVDFYSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVG 626
Query: 1012 FRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRD--AVVRTVVGLDRETTAAYMLI 1069
VV ++ D D ++ ++Y IT GN +FS+ + +V + LD + Y+L
Sbjct: 627 TSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLA 684
Query: 1070 LEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDA 1129
+ A D G R TA + V V D N +RP+F S Y +V ED P G +++ + ATD
Sbjct: 685 VTASD----GTRQ-DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDE 739
Query: 1130 DEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMR 1189
D GE R+ Y + FRI G + LD E S+ L + A ++ +
Sbjct: 740 DTGENARITY--FMEDSIPQFRIDADTGAVTT-QAELDYEDQVSYTLAITARDNGIPQKS 796
Query: 1190 SSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL 1249
+ + + V D+ND AP F + Y + E TSV+ + ATDRDSG G V Y
Sbjct: 797 DTTYLEILVNDVNDNAPQFLRDSYQG-SVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQ 855
Query: 1250 SG--AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNEL 1307
G +G F ++ ++G++ T+ LD E Y++ A D+ P + V +T+L+
Sbjct: 856 GGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVLDVN 915
Query: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN--QITYRFNAYTSTQAKALFKID 1365
D F ++ + EN +G + RV A D QI Y+ +F++D
Sbjct: 916 DNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQI---VEGNIPEVFQLD 972
Query: 1366 AITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSP---RFDFTS 1422
+G +T +D E Y L + A P V S V++ +LD NDN P F+
Sbjct: 973 IFSGELTALVDLDYEDRPEYVLVIQA-TSAPLV-SRATVHVRLLDRNDNPPVLGNFEILF 1030
Query: 1423 DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVA 1482
++ V+ G + V A DPD + + +S GN +V N S GE+ ++
Sbjct: 1031 NNYVTNRSSSFPGGAIGRVPAHDPDISDS--LTYSFERGN---ELSLVLLNASTGELKLS 1085
Query: 1483 RPLDREELDHYILQVVASDRGTPPRKKDHILQVTIL 1518
R LD I+ V+ SD G L+VTI+
Sbjct: 1086 RALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTII 1120
Score = 388 bits (997), Expect = e-107
Identities = 306/980 (31%), Positives = 475/980 (48%), Gaps = 79/980 (8%)
Query: 1740 NVPTFPRDYEGPFEVT--EGQP-GPRVWTFLAHDRDSGPNGQVEYS---IMDGDPLGEFV 1793
NV T P+ ++ T E QP G V + A D D G G++EY+ + D F
Sbjct: 174 NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFS 233
Query: 1794 ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLN 1853
+ PV G + + ELDRET + + + A+D GMP S+ + I V D ND+DPV
Sbjct: 234 LDPVTGAVTTAE--ELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQ 291
Query: 1854 LPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAGNRERAFFINATTGIVTV 1910
++ EN V V V A+D D+ NA + + + + G+ F I+ +G++
Sbjct: 292 QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRT 351
Query: 1911 NRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVME 1970
P+DRE + Y+LT+ D +P R + + + D+NDN P F++ Y +V E
Sbjct: 352 RGPVDREEVESYQLTVEASDQGRDPG-PRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRE 410
Query: 1971 NSPAGTPLTVLNGPILALDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDR 2029
+ G P+ + A D D+ AVV Y ++ G G F +++ TG + V S +D
Sbjct: 411 DVTPGAPVL----RVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSP--LDY 464
Query: 2030 EAFSPPILELLLLAEDIG---LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGF 2086
E L + A+D G L N + + + +LD NDN P F +LE+ P G+
Sbjct: 465 ETTKEYTLRVR--AQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGY 522
Query: 2087 SVLQVTATDEDSGLNGELVYRIEAGAQD-RFLIHLVTGVIRVGNATIDREEQESYRLTVV 2145
VL V A D D+G N L YR+ D F I+ TG I V A +DREE + Y V
Sbjct: 523 LVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVA-AELDREEVDFYSFGVE 581
Query: 2146 ATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP 2205
A D GT L+ +A V++ + D+ND+ P F P TV + E A GT + ++A+D D +
Sbjct: 582 ARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHS 641
Query: 2206 KLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKS--PMNRELVATYEVTLSVIDN 2263
+ Y I N + F++ +G +V P++ +L Y + ++ D
Sbjct: 642 VITYQITS-----------GNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDG 690
Query: 2264 ASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDP 2323
A++ VNV D N + P F+ ++Y + E GTT++ ++A D
Sbjct: 691 TRQ--------DTAQIVVNVTDANTHRPVFQS---SHYTVNVNEDRPAGTTVVLISATDE 739
Query: 2324 DKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRA 2383
D G N +TY + D +P + D+ G V +DYE+ + A DNG P ++
Sbjct: 740 DTGENARITYFMEDSIPQFRI---DADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKS 796
Query: 2384 AEIPVYLEIV--DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL 2441
YLEI+ D+NDN P F + SYQ +V+EDVP T +L ++ATD DSG + Y+
Sbjct: 797 DT--TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTF 854
Query: 2442 ---GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2498
DG+ F + T+G + L LDRE Y+L A A D A ++V +
Sbjct: 855 QGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPA----RTPMEVTVT 910
Query: 2499 VLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFH 2557
VLDVND P F + +F V EN P G +V + ATD DEG N ++ Y + EG E F
Sbjct: 911 VLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQ 970
Query: 2558 VDMDSGLVTTQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNG 2617
+D+ SG +T L YE V+ PL + V ++D NDN PV N
Sbjct: 971 LDIFSGELTALVDLD-YEDRPEYVLVIQATSAPLVSRATVHVRLLDRNDNPPVL---GNF 1026
Query: 2618 TILHIREEIPLRSNVYEVYATDK----DEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLI 2673
IL + RS+ + A + D ++ ++ YSF + GN + +++ +G +
Sbjct: 1027 EIL-FNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFER--GN-ELSLVLLNASTGEL 1082
Query: 2674 QTAQRLD--RESQAVYSLIL 2691
+ ++ LD R +A+ S+++
Sbjct: 1083 KLSRALDNNRPLEAIMSVLV 1102
Score = 388 bits (996), Expect = e-107
Identities = 316/984 (32%), Positives = 471/984 (47%), Gaps = 78/984 (7%)
Query: 42 ISEDTPVGSSVTQLLAQDMDN------DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDR 95
+ E+ P G+ V L A D D + + + +++FF+++P TG V + LDR
Sbjct: 190 VPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVTGAVTTAEELDR 249
Query: 96 ETKSEFTVEFSVSDHQGVITRK----VNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPI 151
ETKS + DH G+ R + I V D ND+ P F Q Y + EN VG +
Sbjct: 250 ETKSTHVFRVTAQDH-GMPRRSALATLTILVTDTNDHDPVFEQQEYKESLRENLEVGYEV 308
Query: 152 FIVNATDPDLGAGGSVLY-----SFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
V ATD D ++LY S PS+ F ID G++ +D E ++YQLTV
Sbjct: 309 LTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGPVDREEVESYQLTVE 368
Query: 207 ATDQDK-TRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
A+DQ + P ST A + + + D D P F Y + E PG V +TA D+DK
Sbjct: 369 ASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVREDVTPGAPVLRVTASDRDK 428
Query: 266 GRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTP 325
G + Y+I+SGN F LD +G L + LD E + + L V+ D P
Sbjct: 429 GSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYET---TKEYTLRVRA---QDGGRP 482
Query: 326 SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSM 385
+ V+ + V+DINDNAP F S+ + + E +G+ L L +Q +D D G N+
Sbjct: 483 PLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGY-LVLHVQAIDAD--AGDNAR 539
Query: 386 FEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYA 444
E L G H F + + G I VA LD E VD Y F + A + P A
Sbjct: 540 LEYRLAG-VGHDFPFTINNGTG----WISVAAELDREEVDFYSFGVEARDHGTPALTASA 594
Query: 445 KVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPD 504
V +T+++ NDN P F+QP Y + L E+ VGTSV+TV A D DA + + +
Sbjct: 595 SVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRN 654
Query: 505 RFSLDKDT--GLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQ 562
RFS+ + GL+ L LDY+L +++ L + A DG ++ T ++ +NV D N + P FQ
Sbjct: 655 RFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQD-TAQIVVNVTDANTHRPVFQ 713
Query: 563 KDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVIS 622
Y + E+ P+ T +V + ATDED+ N +ITY + S + G ++
Sbjct: 714 SSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED-----SIPQFRIDADTGAVT 768
Query: 623 VSRPLDYE-QISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVV 681
LDYE Q+S L + A D G P + T + I V D NDN P F + +Y SV
Sbjct: 769 TQAELDYEDQVS---YTLAITARDNGIPQKSDTTYLEILVNDVNDNAPQFLRDSYQGSVY 825
Query: 682 ENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST----QFRINARSGEITTTSLLDRE 737
E++ +VL ++ATD D + Y+ +G F + + SG + T LDRE
Sbjct: 826 EDVPPFTSVLQISATDRDSGL---NGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRE 882
Query: 738 TKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDV 797
++Y+L AVD G+ + V +T+LD+NDN P ++ + + + E +P V
Sbjct: 883 NVAQYVLRAYAVDKGMPPARTP--MEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAV 940
Query: 798 TTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855
V A DPD G N ++Y I N + + L+ +G++ A++D + D E L
Sbjct: 941 ARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELT---ALVDLDYEDRPEYVL--- 994
Query: 856 IVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLP-----FVAEVLEGIPAGVSIY 910
V+ T PL S ATV V LLD NDN P N +V P G +I
Sbjct: 995 -VIQATSA---PL--VSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSFPGG-AIG 1047
Query: 911 QVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDA 970
+V A D D ++ ++Y G L+N+S+G + + LD R E + V+ SD
Sbjct: 1048 RVPAHDPD--ISDSLTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMSVLVSDG 1105
Query: 971 GTPTKSSTSTLTIHVLDVNDETPT 994
S T+ + V + DE T
Sbjct: 1106 ---VHSVTAQCALRVTIITDEMLT 1126
Score = 385 bits (990), Expect = e-106
Identities = 312/984 (31%), Positives = 465/984 (47%), Gaps = 57/984 (5%)
Query: 343 DNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLG--LNSMFEVYLVGNNSHHFII 400
+ AP+F Y + E G + ++ +D DE L + ++ F +
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVAS-LRAIDPDEGEAGRLEYTMDALFDSRSNQFFSL 234
Query: 401 SPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPI 459
P + + A LD ET + F + A + +P A + I + + ND+ P+
Sbjct: 235 DPVTGA------VTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPV 288
Query: 460 FSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF-----SDDPDRFSLDKDTGL 514
F Q Y SL EN+ VG VLTV ATD DA + Y + F +D +G+
Sbjct: 289 FEQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGV 348
Query: 515 IMLIARLDYELIQRFTLTIIA----RDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGAL 570
I +D E ++ + LT+ A RD G TT V ++V D NDN P F + YV +
Sbjct: 349 IRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
Query: 571 RENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYE 630
RE+ ++R+ A+D D N + YSI+S +A G ++ L G + V PLDYE
Sbjct: 409 REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFY---LDAQTGALDVVSPLDYE 465
Query: 631 QISNGLIYLTVMAMDAGNPPL-NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT 689
L V A D G PPL N + VT++V D NDN P F + +V+E++ G
Sbjct: 466 TTKE--YTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYL 523
Query: 690 VLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAV 749
VL + A D D E + + F IN +G I+ + LDRE Y V A
Sbjct: 524 VLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEAR 583
Query: 750 DGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGE 809
D G T A+V++T+LD+NDN+PT+ Y + L E + V TV AVD D
Sbjct: 584 DHGT--PALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD--A 639
Query: 810 NGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP 867
+ + Y I N +S+ S +G + A+ P + +L R+ V++VT
Sbjct: 640 HSVITYQITSGNTRNRFSITSQSGGGLVSLAL-------PLDYKLERQYVLAVTASDG-- 690
Query: 868 LKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSY 927
+A + VN+ D N + P FQ+ + V E PAG ++ + A D D G N ++Y
Sbjct: 691 -TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY 749
Query: 928 RMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLD 987
M +P+ F I++ +G V T ELD E Y L + A D G P KS T+ L I V D
Sbjct: 750 FMEDSIPQ--FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTYLEILVND 807
Query: 988 VNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGG-NVDGKFSVG 1046
VND P F Y SV EDVP V+ ++ TD D GLN + Y GG + DG F V
Sbjct: 808 VNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVE 867
Query: 1047 YRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
+VRT+ LDRE A Y+L A+D G R T VTVLDVNDN P+F Q
Sbjct: 868 STSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVT--VTVLDVNDNPPVFEQDE 925
Query: 1107 YEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPL 1166
++ V E+ P G ++ ++ ATD DEG ++ Y+I+ GN F++ + +G L L
Sbjct: 926 FDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGEL-TALVDL 984
Query: 1167 DRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQY---SRLGLRETAG 1223
D E +VL+++A + P+ S V V + D ND PV + + + R ++
Sbjct: 985 DYEDRPEYVLVIQATS---APLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRSSSF 1041
Query: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMN 1282
G ++ V A D D D + Y G E ++ STG + LD +M+
Sbjct: 1042 PGGAIGRVPAHDPDISDS--LTYSFERGNELSLVLLNASTGELKLSRALDNNRPLEAIMS 1099
Query: 1283 VSATDQAPPFNQGFCSVYITLLNE 1306
V +D C++ +T++ +
Sbjct: 1100 VLVSDGVHSVT-AQCALRVTIITD 1122
Score = 370 bits (949), Expect = e-101
Identities = 291/898 (32%), Positives = 432/898 (48%), Gaps = 65/898 (7%)
Query: 127 DNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQP-----PSQFFAID 181
+ AP F Y +PEN P GTP+ + A DPD G G + Y+ +QFF++D
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLD 235
Query: 182 SARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPY 241
G VT ELD ET + V A D R S LA L I++TD D DP+F Y
Sbjct: 236 PVTGAVTTAEELDRETKSTHVFRVTAQDHGMPR-RSALATLTILVTDTNDHDPVFEQQEY 294
Query: 242 STNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNS---IFALDYISGVLTLNGL 298
++ E+ G V + A D D I Y ++ G+ S +F +D SGV+ G
Sbjct: 295 KESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIRTRGP 354
Query: 299 LDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAIT 358
+DRE + LTV+ ++ R P + T + V D NDNAP+F+ Y V +
Sbjct: 355 VDREE---VESYQLTVEASD--QGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVR 409
Query: 359 ELAQVGFALPLFIQVVDKDENLGLNSMFEVYLV-GNNSHHFIISPTSVQGKADIRIRVAI 417
E G + ++V D + G N++ ++ GN F + + G D V
Sbjct: 410 EDVTPGAPV---LRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQT--GALD----VVS 460
Query: 418 PLDYETVDRYDFDLFANESVPDHVGYAK--VKITLINENDNRPIFSQPLYNISLYENVTV 475
PLDYET Y + A + + V + +++ NDN PIF + ++ E+V +
Sbjct: 461 PLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPL 520
Query: 476 GTSVLTVLATDNDAGTFGEVSYFFS----DDPDRFSLDKDTGLIMLIARLDYELIQRFTL 531
G VL V A D DAG + Y + D P F+++ TG I + A LD E + ++
Sbjct: 521 GYLVLHVQAIDADAGDNARLEYRLAGVGHDFP--FTINNGTGWISVAAELDREEVDFYSF 578
Query: 532 TIIARDGGGEETT--GRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDED 589
+ ARD G T V + VLDVNDN PTF + Y L E+ T +V + A D D
Sbjct: 579 GVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638
Query: 590 SPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNP 649
+ ++ ITY I S + + F I+ G G++S++ PLDY+ L V+A+ A +
Sbjct: 639 A--HSVITYQITSGNT-RNRFSITSQSGGGLVSLALPLDYK-----LERQYVLAVTASDG 690
Query: 650 PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESI 709
T + + V D N + P F Y V+V E+ AG TV+ ++ATD D I
Sbjct: 691 TRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGE---NARI 747
Query: 710 IYSLEGS-TQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITL 768
Y +E S QFRI+A +G +TT + LD E + Y L + A D G+ QK+ + I +
Sbjct: 748 TYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGI--PQKSDTTYLEILV 805
Query: 769 LDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ---PPNKFYS 825
D+NDN P + Y ++ E PP + V + A D D G NG + Y+ Q + +
Sbjct: 806 NDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFI 865
Query: 826 LNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLND 885
+ ST+G +RT LDREN + ++R V D G PP + TV V LD+ND
Sbjct: 866 VESTSGIVRTLR-RLDRENVAQY---VLRAYAV---DKGMPPARTPMEVTVTV--LDVND 916
Query: 886 NDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSG 945
N P F+ F V E P G+++ +V A D DEG N + Y++ G F ++ SG
Sbjct: 917 NPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSG 976
Query: 946 VVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF--FPAVYN 1001
+ +LD E EY L + A+ A S +T+ + +LD ND P F ++N
Sbjct: 977 ELTALVDLDYEDRPEYVLVIQATSA---PLVSRATVHVRLLDRNDNPPVLGNFEILFN 1031
Score = 342 bits (877), Expect = 4e-93
Identities = 297/982 (30%), Positives = 464/982 (47%), Gaps = 76/982 (7%)
Query: 1629 DNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTY---AIVAGNIVNTFRI 1685
+ AP FQ P Y+ + E T + +++A+D DEG G + Y A+ F +
Sbjct: 176 NTAPQFQPPSYQATVPEN-QPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSL 234
Query: 1686 DRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFP 1745
D G +T A+ELD E + + VTA D R ++ T+ + V D ND+ P F
Sbjct: 235 DPVTGAVTTAEELDRE-TKSTHVFRVTAQDHG---MPRRSALATLTILVTDTNDHDPVFE 290
Query: 1746 RDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMD---GDPLGEFVISPVEGVLR 1802
+ + G V T A D D+ PN + Y +++ G P F I P GV+R
Sbjct: 291 QQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVIR 350
Query: 1803 VRKDVELDRETIAFYNLTICARDRGMP--PLSSTMLVGIRVLDINDNDPVLLNLPMNITI 1860
R V DRE + Y LT+ A D+G P S+T V + V D NDN P + +
Sbjct: 351 TRGPV--DREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQV 408
Query: 1861 SENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP 1920
E+ + V V ASD D G NA + ++I +GN F+++A TG + V PLD E
Sbjct: 409 REDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTK 468
Query: 1921 EYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV 1980
EY L + +D P L+ + + D NDN P+F + +QA V+E+ P G V
Sbjct: 469 EYTLRVRAQDGGRPP--LSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLG--YLV 524
Query: 1981 LNGPILALDADQDIYAVVTYQLLGAQSGL-FDINSSTGVVTVRSGVIIDREAFSPPILEL 2039
L+ + A+DAD A + Y+L G F IN+ TG ++V + +DRE
Sbjct: 525 LH--VQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAE--LDREEVD--FYSF 578
Query: 2040 LLLAEDIG--LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDED 2097
+ A D G L ++A + +T+LD NDN PTF+ TV L E+ G SV+ V+A D D
Sbjct: 579 GVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638
Query: 2098 SGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNA-TIDREEQESYRLTVVATDRGTVPLS 2155
+ + + Y+I +G ++RF I +G V A +D + + Y L V A+D GT
Sbjct: 639 A--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD-GT--RQ 693
Query: 2156 GTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVG 2213
TA + + + D N RP F + TV+V E GT + I+A D D N ++ Y +
Sbjct: 694 DTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITYFMED 753
Query: 2214 IVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVS 2273
+ + F ++ +TG+V ++ ++ E +Y + ++ DN +P++S
Sbjct: 754 SIPQ-------------FRIDADTGAVTTQAELDYEDQVSYTLAITARDNG--IPQKS-- 796
Query: 2274 VPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTY 2333
L + V DVNDN PQF Y + E P T+++ ++A D D GLNG V Y
Sbjct: 797 -DTTYLEILVNDVNDNAPQFLR---DSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFY 852
Query: 2334 TLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
T + +S++G V R +D E V A D G PP + V + ++
Sbjct: 853 TFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYAVDKGMPPARTPMEVTVTVL 912
Query: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE--SKFAIN 2451
D+NDN P+F+Q + V E+ P+G + VTATD D G A I Y + +G F ++
Sbjct: 913 DVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLD 972
Query: 2452 PTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSK 2511
+G++ L LD E + Y+L A P + V +++LD ND P
Sbjct: 973 IFSGELTALVDLDYEDRPEYVLVIQATSAP-------LVSRATVHVRLLDRNDNPPVLGN 1025
Query: 2512 PQFSTSVYENEPA----GTSVITMMATDQDEGPNGELTYSLE-GPGVEAFHVDMDSGLVT 2566
+ + Y + G ++ + A D D + LTYS E G + ++ +G +
Sbjct: 1026 FEILFNNYVTNRSSSFPGGAIGRVPAHDPD--ISDSLTYSFERGNELSLVLLNASTGELK 1083
Query: 2567 TQRPLQSYEKFS--LTVVATDG 2586
R L + ++V+ +DG
Sbjct: 1084 LSRALDNNRPLEAIMSVLVSDG 1105
Score = 329 bits (844), Expect = 2e-89
Identities = 263/836 (31%), Positives = 403/836 (48%), Gaps = 69/836 (8%)
Query: 2067 PTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR----FLIHLVT 2122
P F P + + EN P G V + A D D G G L Y ++A R F + VT
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 2123 GVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVS 2182
G + +DRE + ++ V A D G S A +TIL+ D ND P F S
Sbjct: 239 GAVTTAEE-LDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
Query: 2183 VLESAEPGTVIANITAIDHDLNPKLE--YHIVGIVAKDDTDRLVPNQEDAFAVNINTGSV 2240
+ E+ E G + + A D D P Y ++ + + + F ++ +G +
Sbjct: 298 LRENLEVGYEVLTVRATDGDAPPNANILYRLL--------EGSGGSPSEVFEIDPRSGVI 349
Query: 2241 MVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY 2300
+ P++RE V +Y++T+ D D RS + A + ++V D NDN PQF
Sbjct: 350 RTRGPVDREEVESYQLTVEASDQGRDPGPRSTT---AAVFLSVEDDNDNAPQFSE---KR 403
Query: 2301 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTV 2360
Y+ ++ E TPG ++ V A D DKG N +V Y+++ G L D+ G + +
Sbjct: 404 YVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYL-DAQTGALDVVSPL 462
Query: 2361 DYEEVHWLNFTVRASDNGSPPRA-AEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
DYE VRA D G PP + V ++++DINDN PIF +Q V E VP+G
Sbjct: 463 DYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGY 522
Query: 2420 IILTVTATDADSGNFALIEYSL-GDGES-KFAINPTTGDIYVLSSLDREKKDHYILTALA 2477
++L V A DAD+G+ A +EY L G G F IN TG I V + LDRE+ D Y A
Sbjct: 523 LVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEA 582
Query: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD 2537
+D+ + S V + VLDVND P F++P+++ + E+ GTSV+T+ A D+D
Sbjct: 583 RDHGTPALTA----SASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRD 638
Query: 2538 EGPNGELTYSL-EGPGVEAFHVDMDSG--LVTTQRPL--QSYEKFSLTVVATDGGEPPLW 2592
+ +TY + G F + SG LV+ PL + ++ L V A+DG
Sbjct: 639 A--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASDGTRQD-- 694
Query: 2593 GTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSF 2652
T ++V V D N +RPVF + +++ E+ P + V + ATD+D G N + Y F
Sbjct: 695 -TAQIVVNVTDANTHRPVF--QSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY-F 750
Query: 2653 LKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVAL 2712
++ + + F ID +G + T LD E Q Y+L + A D G P +T L++ +
Sbjct: 751 MEDSIPQ----FRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDTTY-LEILV 805
Query: 2713 EDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGN 2772
D++DN P F+R Y E P T V ++ A D D G N V+Y G+
Sbjct: 806 NDVNDNAPQFLRDSYQGSVY------EDVPPFTSVLQIS-ATDRDSGLNGRVFYTFQGGD 858
Query: 2773 E-EKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQ 2830
+ + +F ++ G + LR LDRE A ++++A + PP T
Sbjct: 859 DGDGDFIVESTSGIVRTLRRLDRENVA--QYVLRAYAVDKGMPPAR-----------TPM 905
Query: 2831 EVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
EV V + D+ND PP F + E+ V ++ +G + +V A D D G N+ + Y I+
Sbjct: 906 EVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIV 961
Score = 258 bits (658), Expect = 9e-68
Identities = 236/820 (28%), Positives = 368/820 (44%), Gaps = 85/820 (10%)
Query: 2169 DSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP--KLEYHIVGIVAKDDTDRLVPN 2226
++ P+F P +V E+ GT +A++ AID D +LEY + D L +
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTM---------DALFDS 226
Query: 2227 QEDA-FAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLD 2285
+ + F+++ TG+V ++RE +T+ ++ D+ +P RS A LT+ V D
Sbjct: 227 RSNQFFSLDPVTGAVTTAEELDRETKSTHVFRVTAQDHG--MPRRSAL---ATLTILVTD 281
Query: 2286 VNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLV--PPGY 2343
ND+ P F+ Y E + E G ++ V A D D N + Y LL+ P
Sbjct: 282 TNDHDPVFEQ---QEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSE 338
Query: 2344 VQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP--PRAAEIPVYLEIVDINDNNPI 2401
V D +G + VD EEV TV ASD G PR+ V+L + D NDN P
Sbjct: 339 VFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQ 398
Query: 2402 FDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYV 2459
F + Y V EDV G +L VTA+D D G+ A++ YS+ G+ +F ++ TG + V
Sbjct: 399 FSEKRYVVQVREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDV 458
Query: 2460 LSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVY 2519
+S LD E Y L A+D SN S V +QVLD+ND P F F +V
Sbjct: 459 VSPLDYETTKEYTLRVRAQDGGRPPLSN---VSGLVTVQVLDINDNAPIFVSTPFQATVL 515
Query: 2520 ENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVE-AFHVDMDSGLVTTQRPL--QSYEK 2576
E+ P G V+ + A D D G N L Y L G G + F ++ +G ++ L + +
Sbjct: 516 ESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDF 575
Query: 2577 FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVY 2636
+S V A D G P L + + V V+DVNDN P F +P + + E+ + ++V V
Sbjct: 576 YSFGVEARDHGTPALTASASVSVTVLDVNDNNPTFTQPE--YTVRLNEDAAVGTSVVTVS 633
Query: 2637 ATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPI-SGLIQTAQRLDRESQAVYSLILVASD 2695
A D+D + + Y T+GN F I GL+ A LD + + Y L + ASD
Sbjct: 634 AVDRD--AHSVITYQI--TSGNTRNRFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD 689
Query: 2696 LGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVD 2755
+T Q + V + D + + P+F + + V E P GT V ++ A D
Sbjct: 690 ---GTRQDTAQ-IVVNVTDANTHRPVF------QSSHYTVNVNEDRPAGTTVVLIS-ATD 738
Query: 2756 ADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPP 2814
D G NA + YF+ + F + D G + +LD E + ++ + A N P
Sbjct: 739 EDTGENARITYFME--DSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDN--GIPQ 794
Query: 2815 RGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDAD 2874
+ + L+ +++ D+ND P+F + Y V D + ++Q+ A D D
Sbjct: 795 KSDTTYLE-----------ILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRD 843
Query: 2875 IGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVA 2934
G N VFY+ +D F + S GI+RT + +V+ A
Sbjct: 844 SGLNGRVFYTF----------QGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAYA 893
Query: 2935 RDLAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEE 2974
D G+ R V + + ++ D FE++
Sbjct: 894 VDK---------GMPPARTPMEVTVTVLDVNDNPPVFEQD 924
Score = 181 bits (459), Expect = 1e-44
Identities = 152/572 (26%), Positives = 260/572 (45%), Gaps = 34/572 (5%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVFG--VSGEEASRF-FAVEPDTGVVWLRQPLDRETK 98
++ED VG+SV + A D D ++ SG +RF + G+V L PLD + +
Sbjct: 619 LNEDAAVGTSVVTVSAVDRDAHSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLE 678
Query: 99 SEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATD 158
++ + + SD T ++ + V D N + P F + Y+V + E+ P GT + +++ATD
Sbjct: 679 RQYVLAVTASDGTRQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATD 738
Query: 159 PDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLST 218
D G + Y + F ID+ G VT ELDYE +Y L + A D + T
Sbjct: 739 EDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARDNGIPQKSDT 798
Query: 219 LANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSG 278
L I++ DV D P F+ Y ++YE PP T+V I+A D+D G + YT G
Sbjct: 799 -TYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGG 857
Query: 279 NT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTE--LNDDRTPSDATVTTTFN 335
+ + F ++ SG++ LDREN ++L + + RTP + TVT
Sbjct: 858 DDGDGDFIVESTSGIVRTLRRLDRENVAQ---YVLRAYAVDKGMPPARTPMEVTVT---- 910
Query: 336 ILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS 395
V+D+NDN P F E+ V + E + +G A+ + D DE M+++ + GN
Sbjct: 911 --VLDVNDNPPVFEQDEFDVFVEENSPIGLAVAR-VTATDPDEGTNAQIMYQI-VEGNIP 966
Query: 396 HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINEND 455
F + S + + + LDYE DR ++ L + V A V + L++ ND
Sbjct: 967 EVFQLDIFSGE------LTALVDLDYE--DRPEYVLVIQATSAPLVSRATVHVRLLDRND 1018
Query: 456 NRPIFS--QPLYN--ISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKD 511
N P+ + L+N ++ + G ++ V A D D S+ ++ L+
Sbjct: 1019 NPPVLGNFEILFNNYVTNRSSSFPGGAIGRVPAHDPDISDSLTYSFERGNELSLVLLNAS 1078
Query: 512 TGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGAL- 570
TG + L LD ++++ D G T + + V + D + T + +
Sbjct: 1079 TGELKLSRALDNNRPLEAIMSVLVSD-GVHSVTAQCALRVTIITDEMLTHSITLRLEDMS 1137
Query: 571 --RENEPSVTQLVRLRATDEDSPPNNQITYSI 600
R P + ++ A +PP++ + +++
Sbjct: 1138 PERFLSPLLGLFIQAVAATLATPPDHVVVFNV 1169
>gi|7656967 cadherin EGF LAG seven-pass G-type receptor 1 [Homo
sapiens]
Length = 3014
Score = 413 bits (1062), Expect = e-114
Identities = 329/1008 (32%), Positives = 496/1008 (49%), Gaps = 67/1008 (6%)
Query: 899 VLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM----PRMDFLINSSSGVVVTTTELD 954
+ E PAG I Q+ A EG VSY M G+ R F I+S++G V T + LD
Sbjct: 254 LFENEPAGTLILQLHAHYTIEGEEERVSYYME-GLFDERSRGYFRIDSATGAVSTDSVLD 312
Query: 955 RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
RE + LRV A D TP +S+T+ +T+ V D ND +P F + Y V E++ + V
Sbjct: 313 RETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEV 372
Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAID 1074
+ + +D D +NA L Y + GG D F + VV T LDRE A Y L++EA D
Sbjct: 373 LTIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEYQLLVEAND 431
Query: 1075 NGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF 1134
G + TATV++ V D NDN P F + +Y VPED+ ++L+++ATD D+G+
Sbjct: 432 QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQN 491
Query: 1135 GRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRV 1194
+ Y IL GN F +H +G+L PLD E + L ++A + P+ +S V
Sbjct: 492 AAIHYSILSGNVAGQFYLHSLSGIL-DVINPLDFEDVQKYSLSIKAQDGGRPPLINSSGV 550
Query: 1195 I-VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGA- 1252
+ V V D+ND P+F + L E +G V+ +QA D DSG+ ++YR++ A
Sbjct: 551 VSVQVLDVNDNEPIFVSSPFQATVL-ENVPLGYPVVHIQAVDADSGENARLHYRLVDTAS 609
Query: 1253 -----------------EGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQG 1295
+ F+I S+G I LD E Y V A D P
Sbjct: 610 TFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPPMSS 669
Query: 1296 FCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTS 1355
SV IT+L+ D F+ +YE + E+ A+G+ ++ +QA D + ITY+ +
Sbjct: 670 STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTG-GN 728
Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNS 1415
T+ + G+IT+ +D ++ Y L V A DG T V I V D N +
Sbjct: 729 TRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG--TRSHTAHVLINVTDANTHR 786
Query: 1416 PRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDS 1475
P F +S VS+ ED PVG +AT+ A D D G N ++ + + + F I +
Sbjct: 787 PVFQ-SSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQ--DPVPQFRI---DPD 840
Query: 1476 IGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNV 1535
G ++ LD E Y L ++A D G P + L++ ILD NDN P F Y
Sbjct: 841 SGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDF-YQG 899
Query: 1536 SVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNK-DMAFRMDRISGEIATRPAPPDR 1594
S+ E+ T+++QV ATDRD G N L Y G+ D F ++ SG I T+ DR
Sbjct: 900 SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQ-RRLDR 958
Query: 1595 ERQSFYHLVATVEDEGTPT-LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTS 1653
E + Y+L A D G+PT LSA+ + VTI+D NDNAPMF++ E+ ++E + + +
Sbjct: 959 ENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMFEKDELELFVEEN-NPVGSV 1017
Query: 1654 LITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTA 1713
+ I+A D DEGPN + Y IV G++ + F++D G + A ELD+E+ Y L+V A
Sbjct: 1018 VAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAMVELDFEVRR-EYVLVVQA 1076
Query: 1714 TDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPF-----EVTEGQPGPRVWTFLA 1768
T S L S TV + + D NDN P P D++ F + P + A
Sbjct: 1077 T------SAPLVSRATVHILLVDQNDNPPVLP-DFQILFNNYVTNKSNSFPTGVIGCIPA 1129
Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
HD D + + Y+ + G+ L ++ P G L++ +D++ +R A +++
Sbjct: 1130 HDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDGIH-- 1185
Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITIS-ENSPVSSFVAHVLA 1875
S T +RV I D+ L +IT+ EN F++ +LA
Sbjct: 1186 ---SVTAFCTLRVTIITDD-----MLTNSITVRLENMSQEKFLSPLLA 1225
Score = 399 bits (1024), Expect = e-110
Identities = 293/915 (32%), Positives = 458/915 (50%), Gaps = 89/915 (9%)
Query: 1959 FTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS-GLFDINSSTG 2017
F YQ + EN PAGT + L+ ++ +++ + L +S G F I+S+TG
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHY-TIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 2018 VVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVH 2077
V+ S ++DRE +L + + ++T ++ + + D ND+ P F +
Sbjct: 304 AVSTDS--VLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRER 361
Query: 2078 LLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQ 2137
+ EN G+ VL + A+D DS +N L YR+ GA D F ++ +GV+ A +DREE
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVVST-RAVLDREEA 420
Query: 2138 ESYRLTVVATDRGTVP--LSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN 2195
Y+L V A D+G P LS TA V I ++D ND+ P+F V V E T +
Sbjct: 421 AEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLR 480
Query: 2196 ITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVAT 2253
+ A D D N + Y I L N F ++ +G + V +P++ E V
Sbjct: 481 VQATDRDQGQNAAIHYSI-----------LSGNVAGQFYLHSLSGILDVINPLDFEDVQK 529
Query: 2254 YEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF--KPFGITYYMERILEGATP 2311
Y +++ D S V ++V VLDVNDN P F PF T +LE
Sbjct: 530 YSLSIKAQDGGRPPLINSSGV----VSVQVLDVNDNEPIFVSSPFQAT-----VLENVPL 580
Query: 2312 GTTLIAVAAVDPDKGLNGLVTYTLLDLVP----------------PGYVQLEDSSAGKVI 2355
G ++ + AVD D G N + Y L+D P + +S+G +
Sbjct: 581 GYPVVHIQAVDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWIT 640
Query: 2356 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415
+D EEV +F V A D+GSPP ++ V + ++D+NDN+P+F QP+Y+ + ED
Sbjct: 641 VCAELDREEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDA 700
Query: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGD--IYVLSSLDREKKDHYIL 2473
VG+ +LT+ A D D+ + + + G+ ++FA++ G I + LD +++ Y+L
Sbjct: 701 AVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVL 760
Query: 2474 TALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMA 2533
A D R ++ V+I V D N RP F ++ SV E+ P GTS+ T+ A
Sbjct: 761 AVTASD-------GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSA 813
Query: 2534 TDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPL 2591
D+D G N +TY ++ P V F +D DSG + T L ++ ++LT++A D G P
Sbjct: 814 NDEDTGENARITYVIQDP-VPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK 872
Query: 2592 WGTTMLLVEVIDVNDNRPVFVRP-PNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRY 2650
TT L + ++D NDN P F+ G+I E+ P +++ +V ATD+D G NG + Y
Sbjct: 873 SDTTTLEILILDANDNAPQFLWDFYQGSIF---EDAPPSTSILQVSATDRDSGPNGRLLY 929
Query: 2651 SFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQV 2710
+F + + D +F+ I+P SG+I+T +RLDRE+ AVY+L +A D G P P +QV
Sbjct: 930 TF-QGGDDGDGDFY-IEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQV 987
Query: 2711 ALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAA 2770
+ DI+DN P+F + L V E++P G++V + A D DEGPNA + Y I
Sbjct: 988 TILDINDNAPMFEKDELE------LFVEENNPVGSVVAKIR-ANDPDEGPNAQIMYQIVE 1040
Query: 2771 GNEEKNFHLQ-PDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTL 2829
G+ F L +G L + +LD E + +V+A+S LV+ T
Sbjct: 1041 GDMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATS-------------APLVSRAT- 1086
Query: 2830 QEVRVVLEDINDQPP 2844
V ++L D ND PP
Sbjct: 1087 --VHILLVDQNDNPP 1099
Score = 387 bits (993), Expect = e-106
Identities = 298/994 (29%), Positives = 487/994 (48%), Gaps = 73/994 (7%)
Query: 671 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ------FRINAR 724
F P Y V++ EN AG +L L+A + E +E + Y +EG FRI++
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHA---HYTIEGEEERVSYYMEGLFDERSRGYFRIDSA 301
Query: 725 SGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLL--DINDNHPTWKDAP 782
+G ++T S+LDRETK ++L V+AVD ++ AT IT+L D ND+ P ++ +
Sbjct: 302 TGAVSTDSVLDRETKETHVLRVKAVD----YSTPPRSATTYITVLVKDTNDHSPVFEQSE 357
Query: 783 YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN-KFYSLNSTTGKIRTTHAMLD 841
Y + E +V T+ A D D N L Y + + LN ++G + +T A+LD
Sbjct: 358 YRERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGGAWDVFQLNESSGVV-STRAVLD 416
Query: 842 RENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 901
RE ++ ++V D GR P +++ATV++ + D NDN P F +V +V E
Sbjct: 417 REEAAEYQ------LLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPE 470
Query: 902 GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEY 961
+ ++ +V A D D+G N + Y + G F ++S SG++ LD E + +Y
Sbjct: 471 DVGLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKY 530
Query: 962 QLRVVASDAGTPTK-SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCT 1020
L + A D G P +S+ +++ VLDVND P F + + +V E+VP + VV +
Sbjct: 531 SLSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAV 590
Query: 1021 DNDVGLNAELSY--------FITGGNV---------DGKFSVGYRDAVVRTVVGLDRETT 1063
D D G NA L Y F+ GG+ D F + + LDRE
Sbjct: 591 DADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEV 650
Query: 1064 AAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQ 1123
Y +EA+D+G + + +V +TVLDVNDN P+F Q +YE + ED G S+L
Sbjct: 651 EHYSFGVEAVDHG--SPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708
Query: 1124 LKATDADEGEFGRVWYRILHGNHGNNFRIHVS-NGLLMRGPRPLDRERNSSHVLIVEAYN 1182
L+A D D + Y++ GN N F + G L+ PLD ++ +VL V A +
Sbjct: 709 LQARDRDANSV--ITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
Query: 1183 HDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGG 1242
G + V++ V D N PVF Y+ + + E +GTS+ + A D D+G+
Sbjct: 767 ---GTRSHTAHVLINVTDANTHRPVFQSSHYT-VSVSEDRPVGTSIATLSANDEDTGENA 822
Query: 1243 LVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYIT 1302
+ Y ++ +F ID +G + T+ LDYE + +Y + + A D P ++ I
Sbjct: 823 RITY-VIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEIL 881
Query: 1303 LLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKA 1360
+L+ D A QF Y+ +I E+ T I++V A D+ ++ Y F
Sbjct: 882 ILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQG--GDDGDG 939
Query: 1361 LFKIDAITGVITVQGLVDREKGDFYTLTVVADDGG--PKVDSTVKVYITVLDENDNSPRF 1418
F I+ +GVI Q +DRE Y L +A D G + ++V++ +T+LD NDN+P F
Sbjct: 940 DFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF 999
Query: 1419 DFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGE 1478
+ + + + E+ PVG VA ++A DPD G N Q+++ + G++ F++ N G+
Sbjct: 1000 E-KDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLN---GD 1055
Query: 1479 VFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVI---ESPFGYNV 1535
+ LD E Y+L V A+ R HIL ++D NDNPPV+ + F V
Sbjct: 1056 LRAMVELDFEVRREYVLVVQATSAPLVSRATVHIL---LVDQNDNPPVLPDFQILFNNYV 1112
Query: 1536 SVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEI-ATRPAPPDR 1594
+ N + + A D D ++ L+Y +GN+ +D +GE+ +R +R
Sbjct: 1113 TNKSNSFPTGVIGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNR 1170
Query: 1595 ERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEN 1628
++ L+ +G +++A + VTI+ ++
Sbjct: 1171 PLEA---LMEVSVSDGIHSVTAFCTLRVTIITDD 1201
Score = 380 bits (976), Expect = e-104
Identities = 310/963 (32%), Positives = 474/963 (49%), Gaps = 62/963 (6%)
Query: 1000 YNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG---GNVDGKFSVGYRDAVVRTVV 1056
Y V++ E+ P ++ L+ G +SY++ G G F + V T
Sbjct: 250 YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDS 309
Query: 1057 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL--DVNDNRPIFLQSSYEASVPED 1114
LDRET ++L ++A+D + +AT ++TVL D ND+ P+F QS Y V E+
Sbjct: 310 VLDRETKETHVLRVKAVDYSTPPR----SATTYITVLVKDTNDHSPVFEQSEYRERVREN 365
Query: 1115 IPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSH 1174
+ G+ +L ++A+D D + YR+L G + F+++ S+G++ LDRE + +
Sbjct: 366 LEVGYEVLTIRASDRDSPINANLRYRVL-GGAWDVFQLNESSGVVSTRA-VLDREEAAEY 423
Query: 1175 VLIVEAYNH--DLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQ 1232
L+VEA + + GP+ ++ V + VED ND P F++Q Y + + E G+ T+V+ VQ
Sbjct: 424 QLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYV-VQVPEDVGLNTAVLRVQ 482
Query: 1233 ATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQA-P 1290
ATDRD G ++Y ILSG G+F + +G++ +N LD+E Y +++ A D P
Sbjct: 483 ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQDGGRP 542
Query: 1291 PFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN--QITY 1348
P V + +L+ D F ++ ++A +LEN+ LG +V +QA D+ ++ Y
Sbjct: 543 PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHY 602
Query: 1349 RFNAYTST--------------QAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DD 1393
R ST F+I +G ITV +DRE+ + Y+ V A D
Sbjct: 603 RLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDH 662
Query: 1394 GGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQ 1453
G P + S+ V ITVLD NDN P F + + + ED VG V T++A D DA N
Sbjct: 663 GSPPMSSSTSVSITVLDVNDNDPVFTQPTYE-LRLNEDAAVGSSVLTLQARDRDA--NSV 719
Query: 1454 VVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
+ + L GN F + + G + +A PLD ++ Y+L V ASD GT ++
Sbjct: 720 ITYQLTGGNTRNRFALSSQRGG-GLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLI 777
Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
VT D N + PV +S Y VSV+E+ GT++ + A D D G N+ ++Y I +
Sbjct: 778 NVT--DANTHRPVFQSSH-YTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVPQ 834
Query: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPM 1633
FR+D SG + T D E Q Y L +D G P S TT + + I+D NDNAP
Sbjct: 835 --FRIDPDSGTMYTM-MELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQ 891
Query: 1634 FQQPHYE-VLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVN-TFRIDRHMGV 1691
F Y+ + ++ P + TS++ + A D D GPNG + Y G+ + F I+ GV
Sbjct: 892 FLWDFYQGSIFEDAPPS--TSILQVSATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGV 949
Query: 1692 ITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGP 1751
I + LD E + Y L A D+ L+++ + V + DINDN P F +D
Sbjct: 950 IRTQRRLDRE-NVAVYNLWALAVDRGSPTP--LSASVEIQVTILDINDNAPMFEKDELEL 1006
Query: 1752 FEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDR 1811
F G V A+D D GPN Q+ Y I++GD F + + G LR VELD
Sbjct: 1007 FVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLRAM--VELDF 1064
Query: 1812 ETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPM----NITISENSPVS 1867
E Y L + A PL S V I ++D NDN PVL + + +T NS +
Sbjct: 1065 EVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPT 1121
Query: 1868 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTIS 1927
+ + A D D + TF GN R ++ TG + ++R LD R E + +S
Sbjct: 1122 GVIGCIPAHDPDVSDSLNYTF--VQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVS 1179
Query: 1928 VKD 1930
V D
Sbjct: 1180 VSD 1182
Score = 365 bits (938), Expect = e-100
Identities = 296/968 (30%), Positives = 472/968 (48%), Gaps = 80/968 (8%)
Query: 1533 YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA----FRMDRISGEIATR 1588
Y V++ EN GT ++Q+ A G +SYY+ EG D FR+D +G ++T
Sbjct: 250 YQVALFENEPAGTLILQLHAHYTIEGEEERVSYYM-EGLFDERSRGYFRIDSATGAVST- 307
Query: 1589 PAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPD 1648
+ DRE + + L D TP SATT++ V + D ND++P+F+Q Y + E +
Sbjct: 308 DSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLE 367
Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
+ ++TI+A D D N + Y ++ G + F+++ GV++ LD E + Y
Sbjct: 368 -VGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTRAVLDREEA-AEYQ 424
Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRD---YEGPFEVTEGQPGPRVWT 1765
L+V A DQ L++T TV + V D NDN P F + P +V RV
Sbjct: 425 LLVEANDQGRNPGP-LSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQ- 482
Query: 1766 FLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARD 1825
A DRD G N + YSI+ G+ G+F + + G+L V LD E + Y+L+I A+D
Sbjct: 483 --ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINP--LDFEDVQKYSLSIKAQD 538
Query: 1826 RGMPPL-SSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNA 1884
G PPL +S+ +V ++VLD+NDN+P+ ++ P T+ EN P+ V H+ A DADSG NA
Sbjct: 539 GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
Query: 1885 RLTFNI-----------TAGNRERA------FFINATTGIVTVNRPLDRERIPEYKLTIS 1927
RL + + +AG + A F I+ ++G +TV LDRE + Y +
Sbjct: 599 RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVEHYSFGVE 658
Query: 1928 VKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILA 1987
D+ P + + ++ D NDN P+FT+ TY+ + E++ G+ + L
Sbjct: 659 AVDHGSPPMSSSTSVSITVL---DVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQA---- 711
Query: 1988 LDADQDIYAVVTYQLLGAQS-GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDI 2046
D+D +V+TYQL G + F ++S G + + +D + +L + A D
Sbjct: 712 --RDRDANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVT--ASD- 766
Query: 2047 GLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVY 2106
G + TAH+LI + D N +RP F + TV + E+ P G S+ ++A DED+G N + Y
Sbjct: 767 GTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITY 826
Query: 2107 RIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDD 2166
I+ +F I +G + +D E Q +Y LT++A D G S T + ILI D
Sbjct: 827 VIQDPVP-QFRIDPDSGTMYT-MMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEILILD 884
Query: 2167 INDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP--KLEYHIVGIVAKDDTDRLV 2224
ND+ P+FL S+ E A P T I ++A D D P +L Y G DD D
Sbjct: 885 ANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQG---GDDGD--- 938
Query: 2225 PNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVL 2284
F + +G + + ++RE VA Y + +D S P S SV ++ V +L
Sbjct: 939 ----GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTP-LSASV---EIQVTIL 990
Query: 2285 DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYV 2344
D+NDN P F+ + ++E E G+ + + A DPD+G N + Y +++ +
Sbjct: 991 DINDNAPMFEKDELELFVE---ENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFF 1047
Query: 2345 QLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
QL D G + A +D+E V+A+ S P + V++ +VD NDN P+
Sbjct: 1048 QL-DLLNGDLRAMVELDFEVRREYVLVVQAT---SAPLVSRATVHILLVDQNDNPPVLPD 1103
Query: 2405 -----PSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYV 2459
+Y P G +I + A D D + + G+ ++P TG++ +
Sbjct: 1104 FQILFNNYVTNKSNSFPTG-VIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQL 1162
Query: 2460 LSSLDREK 2467
LD +
Sbjct: 1163 SRDLDNNR 1170
Score = 364 bits (935), Expect = e-100
Identities = 297/974 (30%), Positives = 453/974 (46%), Gaps = 69/974 (7%)
Query: 561 FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
F Y AL ENEP+ T +++L A +++Y + S + G
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 621 ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSV 680
+S LD E + L V A+D PP ++T +T+ V D ND+ P F + Y V
Sbjct: 305 VSTDSVLDRETKETHV--LRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERV 362
Query: 681 VENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST--QFRINARSGEITTTSLLDRET 738
EN+ G VL + A+D D ++ Y + G F++N SG ++T ++LDRE
Sbjct: 363 RENLEVGYEVLTIRASDRDSPI---NANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREE 419
Query: 739 KSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVT 798
+EY L+V A D G + ATV I + D NDN+P + + Y + + E ++ V
Sbjct: 420 AAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVL 479
Query: 799 TVVAVDPDLGENGTLVYSIQPPN---KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855
V A D D G+N + YSI N +FY L+S +G +LD NP E
Sbjct: 480 RVQATDRDQGQNAAIHYSILSGNVAGQFY-LHSLSG-------ILDVINPLDFEDVQKYS 531
Query: 856 IVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAI 915
+ + D GRPPL SS V V +LD+NDN+P F + PF A VLE +P G + + A+
Sbjct: 532 LSIKAQDGGRPPL-INSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAV 590
Query: 916 DLDEGLNGLVSYRM-----------------PVGMPRMDFLINSSSGVVVTTTELDRERI 958
D D G N + YR+ P P F I++SSG + ELDRE +
Sbjct: 591 DADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEV 650
Query: 959 AEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLN 1018
Y V A D G+P SS+++++I VLDVND P F Y + ++ED V+ L
Sbjct: 651 EHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQ 710
Query: 1019 CTDNDVGLNAELSYFITGGNVDGKFSVGYR--DAVVRTVVGLDRETTAAYMLILEAIDNG 1076
D D N+ ++Y +TGGN +F++ + ++ + LD + Y+L + A D
Sbjct: 711 ARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASDG- 767
Query: 1077 PVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGR 1136
+ TA V + V D N +RP+F S Y SV ED P G SI L A D D GE R
Sbjct: 768 ----TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENAR 823
Query: 1137 VWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIV 1196
+ Y I + FRI +G M LD E ++ L + A ++ + + + +
Sbjct: 824 ITYVI--QDPVPQFRIDPDSG-TMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
Query: 1197 YVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG--AEG 1254
+ D ND AP F Y + E A TS++ V ATDRDSG G + Y G +G
Sbjct: 881 LILDANDNAPQFLWDFYQG-SIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
Query: 1255 KFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFN-QGFCSVYITLLNELDEAVQF 1313
F I+ ++G+I T LD E Y + A D+ P + +T+L+ D A F
Sbjct: 940 DFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPMF 999
Query: 1314 SNASYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKIDAITGVI 1371
E + EN +G+ + +++A D QI Y+ + F++D + G +
Sbjct: 1000 EKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQI---VEGDMRHFFQLDLLNGDL 1056
Query: 1372 TVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRF-DFT---SDSAVS 1427
+D E Y L V A P V S V+I ++D+NDN P DF ++ +
Sbjct: 1057 RAMVELDFEVRREYVLVVQA-TSAPLV-SRATVHILLVDQNDNPPVLPDFQILFNNYVTN 1114
Query: 1428 IPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDR 1487
P G + + A DPD + + ++ GN ++ + + GE+ ++R LD
Sbjct: 1115 KSNSFPTGV-IGCIPAHDPDVSDS--LNYTFVQGN---ELRLLLLDPATGELQLSRDLDN 1168
Query: 1488 EELDHYILQVVASD 1501
+++V SD
Sbjct: 1169 NRPLEALMEVSVSD 1182
Score = 360 bits (924), Expect = 1e-98
Identities = 303/993 (30%), Positives = 477/993 (48%), Gaps = 76/993 (7%)
Query: 460 FSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS---DDPDR--FSLDKDTGL 514
F P Y ++L+EN GT +L + A G VSY+ D+ R F +D TG
Sbjct: 245 FPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA 304
Query: 515 IMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRE 572
+ + LD E + L + A D + I VL D ND+ P F++ Y +RE
Sbjct: 305 VSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRE 364
Query: 573 NEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQI 632
N +++ +RA+D DSP N + Y ++ G++ L E GV+S LD E+
Sbjct: 365 NLEVGYEVLTIRASDRDSPINANLRYRVLG----GAWDVFQLNESSGVVSTRAVLDREEA 420
Query: 633 SNGLIYLTVMAMDAG-NP-PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATV 690
+ L V A D G NP PL++T V IEV DENDN P FS+ Y V V E++ V
Sbjct: 421 AE--YQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAV 478
Query: 691 LFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVD 750
L + ATD D+ + I S + QF +++ SG + + LD E +Y L ++A D
Sbjct: 479 LRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIKAQD 538
Query: 751 GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGEN 810
GG + V++ +LD+NDN P + +P+ ++E P V + AVD D GEN
Sbjct: 539 GGRPPLINSS-GVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGEN 597
Query: 811 GTLVYSI-------------------QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851
L Y + P+ + +++++G I T A LDRE + +
Sbjct: 598 ARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWI-TVCAELDREEVEHY--- 653
Query: 852 LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQ 911
V D G PP+ +SS +V + +LD+NDNDP F + + E G S+
Sbjct: 654 ---SFGVEAVDHGSPPM--SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLT 708
Query: 912 VVAIDLDEGLNGLVSYRMPVGMPRMDFLINS--SSGVVVTTTELDRERIAEYQLRVVASD 969
+ A D D N +++Y++ G R F ++S G++ LD ++ +Y L V ASD
Sbjct: 709 LQARDRD--ANSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD 766
Query: 970 AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAE 1029
T+S T+ + I+V D N P F + Y VSVSED P + L+ D D G NA
Sbjct: 767 G---TRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENAR 823
Query: 1030 LSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVF 1089
++Y I + +F + + T++ LD E AY L + A DNG K + T T+
Sbjct: 824 ITYVIQ--DPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQK--SDTTTLE 879
Query: 1090 VTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGN- 1148
+ +LD NDN P FL Y+ S+ ED P SILQ+ ATD D G GR+ Y G+ G+
Sbjct: 880 ILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG 939
Query: 1149 NFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNH-DLGPMRSSVRVIVYVEDINDEAPV 1207
+F I ++G++ R R LDRE + + L A + P+ +SV + V + DIND AP+
Sbjct: 940 DFYIEPTSGVI-RTQRRLDRENVAVYNLWALAVDRGSPTPLSASVEIQVTILDINDNAPM 998
Query: 1208 FTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLII 1266
F + + L + E +G+ V ++A D D G + Y+I+ G F++D G +
Sbjct: 999 FEKDEL-ELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLR 1057
Query: 1267 TVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDE-------AVQFSNASYE 1319
+ LD+E + Y++ V AT AP ++ +V+I L+++ D + F+N Y
Sbjct: 1058 AMVELDFEVRREYVLVVQAT-SAPLVSR--ATVHILLVDQNDNPPVLPDFQILFNN--YV 1112
Query: 1320 AAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDR 1379
+ G I + A+ D + + Y F L +D TG + + +D
Sbjct: 1113 TNKSNSFPTGV-IGCIPAHDPDVSDSLNYTF---VQGNELRLLLLDPATGELQLSRDLDN 1168
Query: 1380 EKGDFYTLTVVADDGGPKVDSTVKVYITVLDEN 1412
+ + V DG V + + +T++ ++
Sbjct: 1169 NRPLEALMEVSVSDGIHSVTAFCTLRVTIITDD 1201
Score = 358 bits (920), Expect = 4e-98
Identities = 296/962 (30%), Positives = 449/962 (46%), Gaps = 87/962 (9%)
Query: 1756 EGQP-GPRVWTFLAHDRDSGPNGQVEY---SIMDGDPLGEFVISPVEGVLRVRKDVELDR 1811
E +P G + AH G +V Y + D G F I G V D LDR
Sbjct: 256 ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGA--VSTDSVLDR 313
Query: 1812 ETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVA 1871
ET + L + A D PP S+T + + V D ND+ PV + EN V V
Sbjct: 314 ETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVL 373
Query: 1872 HVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN 1931
+ ASD DS NA L + + G + F +N ++G+V+ LDRE EY+L + D
Sbjct: 374 TIRASDRDSPINANLRYRVLGGAWD-VFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQ 432
Query: 1932 PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDAD 1991
NP + I + DENDN+P F++ Y +V E+ G VL + A D D
Sbjct: 433 GRNPGPLSATATVY-IEVEDENDNYPQFSEQNYVVQVPED--VGLNTAVLR--VQATDRD 487
Query: 1992 QDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVII-DREAFSPPILELLLLAEDIG-- 2047
Q A + Y +L G +G F ++S +G++ V + + D + +S L + A+D G
Sbjct: 488 QGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYS-----LSIKAQDGGRP 542
Query: 2048 -LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVY 2106
L+NS+ + + +LD NDN P F + +LEN P G+ V+ + A D DSG N L Y
Sbjct: 543 PLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENARLHY 602
Query: 2107 RI-----------EAGAQDR-------FLIHLVTGVIRVGNATIDREEQESYRLTVVATD 2148
R+ AG ++ F IH +G I V A +DREE E Y V A D
Sbjct: 603 RLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVC-AELDREEVEHYSFGVEAVD 661
Query: 2149 RGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLE 2208
G+ P+S + V+I + D+ND+ P F P + + E A G+ + + A D D N +
Sbjct: 662 HGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVIT 721
Query: 2209 YHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLP 2268
Y + G N + FA++ G ++ + + + L+V ASD
Sbjct: 722 YQLTG-----------GNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAV--TASD-- 766
Query: 2269 ERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLN 2328
A + +NV D N + P F+ ++Y + E GT++ ++A D D G N
Sbjct: 767 --GTRSHTAHVLINVTDANTHRPVFQS---SHYTVSVSEDRPVGTSIATLSANDEDTGEN 821
Query: 2329 GLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPV 2388
+TY + D VP + D +G + +DYE T+ A DNG P ++ +
Sbjct: 822 ARITYVIQDPVPQFRI---DPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTL 878
Query: 2389 YLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL---GDGE 2445
+ I+D NDN P F YQ ++FED P T IL V+ATD DSG + Y+ DG+
Sbjct: 879 EILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGD 938
Query: 2446 SKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDC 2505
F I PT+G I LDRE Y L ALA D + SV++ + +LD+ND
Sbjct: 939 GDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA---SVEIQVTILDINDN 995
Query: 2506 RPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGL 2564
P F K + V EN P G+ V + A D DEGPN ++ Y + EG F +D+ +G
Sbjct: 996 APMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGD 1055
Query: 2565 VTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHI 2622
+ L + ++ L V AT PL + + ++D NDN PV P+ IL
Sbjct: 1056 LRAMVELDFEVRREYVLVVQATSA---PLVSRATVHILLVDQNDNPPVL---PDFQIL-F 1108
Query: 2623 REEIPLRSNVYEVYATD----KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ +SN + D ++ ++ Y+F++ GN + ++DP +G +Q ++
Sbjct: 1109 NNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQ--GN-ELRLLLLDPATGELQLSRD 1165
Query: 2679 LD 2680
LD
Sbjct: 1166 LD 1167
Score = 334 bits (857), Expect = 8e-91
Identities = 279/916 (30%), Positives = 442/916 (48%), Gaps = 90/916 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMD---NDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
+ E+ VG V + A D D N L + V G A F + +GVV R LDRE
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTRAVLDREEA 420
Query: 99 SEFTVEFSVSDHQG------VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIF 152
+E+ + +D QG T V I+V D NDN P F Q Y V++PE+ + T +
Sbjct: 421 AEYQLLVEAND-QGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVL 479
Query: 153 IVNATDPDLGAGGSVLYSF---QPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATD 209
V ATD D G ++ YS QF+ + S GI+ VI LD+E Q Y L++ A D
Sbjct: 480 RVQATDRDQGQNAAIHYSILSGNVAGQFY-LHSLSGILDVINPLDFEDVQKYSLSIKAQD 538
Query: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269
+ +++ +++ + DV D +PIF++ P+ + E+ P G V I A+D D G
Sbjct: 539 GGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVDADSGENA 598
Query: 270 GIGYTIVSGNTNSI-----------------FALDYISGVLTLNGLLDRENPLYSHGFIL 312
+ Y +V + + F + SG +T+ LDRE + + F
Sbjct: 599 RLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREE-VEHYSF-- 655
Query: 313 TVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQ 372
G E D +P ++ +T+ +I V+D+NDN P F Y + + E A VG ++ L +Q
Sbjct: 656 ---GVEAVDHGSPPMSS-STSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSV-LTLQ 710
Query: 373 VVDKDENLGLNSMFEVYLVGNNSHH-FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDL 431
D+D N S+ L G N+ + F +S G I +A+PLDY+ +Y +
Sbjct: 711 ARDRDAN----SVITYQLTGGNTRNRFALSSQRGGGL----ITLALPLDYKQEQQYVLAV 762
Query: 432 FANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGT 491
A++ H + + +T + N +RP+F Y +S+ E+ VGTS+ T+ A D D G
Sbjct: 763 TASDGTRSHTAHVLINVT--DANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGE 820
Query: 492 FGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRI 549
++Y D +F +D D+G + + LDYE +TLTI+A+D G + T + I
Sbjct: 821 NARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDTTTLEI 880
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSY 609
+LD NDN P F D Y G++ E+ P T ++++ ATD DS PN ++ Y+
Sbjct: 881 LILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDSGPNGRLLYTFQGGDDGDG- 939
Query: 610 FDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNP-PLNSTVPVTIEVFDENDNP 668
D + GVI R LD E ++ + L +A+D G+P PL+++V + + + D NDN
Sbjct: 940 -DFYIEPTSGVIRTQRRLDRENVA--VYNLWALAVDRGSPTPLSASVEIQVTILDINDNA 996
Query: 669 PTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ--FRINARS 725
P F K + V EN G+ V + A D D E I+Y + EG + F+++ +
Sbjct: 997 PMFEKDELELFVEENNPVGSVVAKIRANDPD---EGPNAQIMYQIVEGDMRHFFQLDLLN 1053
Query: 726 GEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYI 785
G++ LD E + EY+L+V+A + ATV+I L+D NDN P D
Sbjct: 1054 GDLRAMVELDFEVRREYVLVVQATSAPL-----VSRATVHILLVDQNDNPPVLPDFQILF 1108
Query: 786 NLVEMTPPDSDVTTVV----AVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLD 841
N +S T V+ A DPD+ ++ + + L+ TG+++ + D
Sbjct: 1109 NNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTFVQGNELRLLLLDPATGELQLSR---D 1165
Query: 842 RENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT--FQNL------ 893
+N P EA LM VSV+D G + A + V + D+ N T +N+
Sbjct: 1166 LDNNRPLEA-LME---VSVSD-GIHSVTAFCTLRVTIITDDMLTNSITVRLENMSQEKFL 1220
Query: 894 -PFVAEVLEGIPAGVS 908
P +A +EG+ A +S
Sbjct: 1221 SPLLALFVEGVAAVLS 1236
Score = 330 bits (847), Expect = 1e-89
Identities = 300/988 (30%), Positives = 454/988 (45%), Gaps = 76/988 (7%)
Query: 44 EDTPVGSSVTQLLAQ---DMDNDPLVFGVSG--EEASR-FFAVEPDTGVVWLRQPLDRET 97
E+ P G+ + QL A + + + + + + G +E SR +F ++ TG V LDRET
Sbjct: 256 ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315
Query: 98 KSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV 154
K + D+ T + + V D ND++P F Y R+ EN VG + +
Sbjct: 316 KETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGYEVLTI 375
Query: 155 NATDPDLGAGGSVLYSFQPPS-QFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKT 213
A+D D ++ Y + F ++ + G+V+ LD E YQL V A DQ +
Sbjct: 376 RASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLVEANDQGRN 435
Query: 214 -RPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIG 272
PLS A + I + D D P F Y + E T V + A D+D+G+ I
Sbjct: 436 PGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLNTAVLRVQATDRDQGQNAAIH 495
Query: 273 YTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTT 332
Y+I+SGN F L +SG+L + LD E+ + L++K D P +
Sbjct: 496 YSILSGNVAGQFYLHSLSGILDVINPLDFED---VQKYSLSIKA---QDGGRPPLINSSG 549
Query: 333 TFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKD--ENLGLN----SMF 386
++ V+D+NDN P F SS + + E +G+ + + IQ VD D EN L+
Sbjct: 550 VVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPV-VHIQAVDADSGENARLHYRLVDTA 608
Query: 387 EVYLVGNNSHHFIISPT-----SVQGKADIRIRVAIPLDYETVDRYDFDLFA-NESVPDH 440
+L G ++ +PT + + I V LD E V+ Y F + A + P
Sbjct: 609 STFLGGGSAGPKNPAPTPDFPFQIHNSSG-WITVCAELDREEVEHYSFGVEAVDHGSPPM 667
Query: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS 500
V IT+++ NDN P+F+QP Y + L E+ VG+SVLT+ A D DA +
Sbjct: 668 SSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVLTLQARDRDANSVITYQLTGG 727
Query: 501 DDPDRFSL--DKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNV 558
+ +RF+L + GLI L LDY+ Q++ L + A D G T V INV D N +
Sbjct: 728 NTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTASD-GTRSHTAHVLINVTDANTHR 786
Query: 559 PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY 618
P FQ Y ++ E+ P T + L A DED+ N +ITY I +
Sbjct: 787 PVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENARITYVIQDPVP-----QFRIDPDS 841
Query: 619 GVISVSRPLDYEQISNGLIY-LTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYF 677
G + LDYE N + Y LT+MA D G P + T + I + D NDN P F Y
Sbjct: 842 GTMYTMMELDYE---NQVAYTLTIMAQDNGIPQKSDTTTLEILILDANDNAPQFLWDFYQ 898
Query: 678 VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST----QFRINARSGEITTTSL 733
S+ E+ ++L ++ATD D S G+ ++Y+ +G F I SG I T
Sbjct: 899 GSIFEDAPPSTSILQVSATDRD-SGPNGR--LLYTFQGGDDGDGDFYIEPTSGVIRTQRR 955
Query: 734 LDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPP 793
LDRE + Y L AVD G + + +T+LDINDN P ++ + + E P
Sbjct: 956 LDRENVAVYNLWALAVDRG-SPTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPV 1014
Query: 794 DSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851
S V + A DPD G N ++Y I + F+ L+ G +R AM++ + E
Sbjct: 1015 GSVVAKIRANDPDEGPNAQIMYQIVEGDMRHFFQLDLLNGDLR---AMVEL------DFE 1065
Query: 852 LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT---FQNL--PFVAEVLEGIPAG 906
+ R+ V+ V P S ATV + L+D NDN P FQ L +V P G
Sbjct: 1066 VRREYVLVVQATSAP---LVSRATVHILLVDQNDNPPVLPDFQILFNNYVTNKSNSFPTG 1122
Query: 907 VSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVV 966
V I + A D D ++ ++Y G L++ ++G + + +LD R E + V
Sbjct: 1123 V-IGCIPAHDPD--VSDSLNYTFVQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVS 1179
Query: 967 ASDAGTPTKSSTSTLTIHVLDVNDETPT 994
SD S T+ T+ V + D+ T
Sbjct: 1180 VSDG---IHSVTAFCTLRVTIITDDMLT 1204
Score = 314 bits (804), Expect = 1e-84
Identities = 268/879 (30%), Positives = 418/879 (47%), Gaps = 74/879 (8%)
Query: 1634 FQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTY---AIVAGNIVNTFRIDRHMG 1690
F P+Y+V L E + T ++ + A EG V+Y + FRID G
Sbjct: 245 FPMPNYQVALFEN-EPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 1691 VITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEG 1750
++ LD E + L V A D + ++TT + V V D ND+ P F + E
Sbjct: 304 AVSTDSVLDRETKE-THVLRVKAVDYS---TPPRSATTYITVLVKDTNDHSPVFEQS-EY 358
Query: 1751 PFEVTEG-QPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVEL 1809
V E + G V T A DRDS N + Y ++ G F ++ GV+ R L
Sbjct: 359 RERVRENLEVGYEVLTIRASDRDSPINANLRYRVLGG-AWDVFQLNESSGVVSTR--AVL 415
Query: 1810 DRETIAFYNLTICARDRGMPP--LSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVS 1867
DRE A Y L + A D+G P LS+T V I V D NDN P + + E+ ++
Sbjct: 416 DREEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQFSEQNYVVQVPEDVGLN 475
Query: 1868 SFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTIS 1927
+ V V A+D D G NA + ++I +GN F++++ +GI+ V PLD E + +Y L+I
Sbjct: 476 TAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKYSLSIK 535
Query: 1928 VKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILA 1987
+D P I ++ + + D NDN P+F S +QA V+EN P G P+ I A
Sbjct: 536 AQDGGRPPLI--NSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVV----HIQA 589
Query: 1988 LDADQDIYAVVTYQLLGAQSGL------------------FDINSSTGVVTVRSGVIIDR 2029
+DAD A + Y+L+ S F I++S+G +TV + +DR
Sbjct: 590 VDADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAE--LDR 647
Query: 2030 EAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVL 2089
E + + ++S+ + IT+LD NDN P F+ T + L E+ G SVL
Sbjct: 648 EEVEHYSFGVEAVDHGSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL 707
Query: 2090 QVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNA-TIDREEQESYRLTVVAT 2147
+ A D D+ N + Y++ G ++RF + G + A +D ++++ Y L V A+
Sbjct: 708 TLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTAS 765
Query: 2148 DRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDL--NP 2205
D GT S TA V I + D N RP F + TVSV E GT IA ++A D D N
Sbjct: 766 D-GT--RSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDRPVGTSIATLSANDEDTGENA 822
Query: 2206 KLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNAS 2265
++ Y ++ + F ++ ++G++ ++ E Y +T+ DN
Sbjct: 823 RITY-------------VIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNG- 868
Query: 2266 DLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDK 2325
+P++S L + +LD NDN PQF +Y I E A P T+++ V+A D D
Sbjct: 869 -IPQKS---DTTTLEILILDANDNAPQFL---WDFYQGSIFEDAPPSTSILQVSATDRDS 921
Query: 2326 GLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSP-PRAA 2384
G NG + YT + ++G + R +D E V N A D GSP P +A
Sbjct: 922 GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTPLSA 981
Query: 2385 EIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG 2444
+ + + I+DINDN P+F++ + V E+ PVG+++ + A D D G A I Y + +G
Sbjct: 982 SVEIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIMYQIVEG 1041
Query: 2445 ESK--FAINPTTGDIYVLSSLDREKKDHYILTALAKDNP 2481
+ + F ++ GD+ + LD E + Y+L A P
Sbjct: 1042 DMRHFFQLDLLNGDLRAMVELDFEVRREYVLVVQATSAP 1080
Score = 313 bits (802), Expect = 2e-84
Identities = 255/844 (30%), Positives = 396/844 (46%), Gaps = 89/844 (10%)
Query: 2076 VHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR----FLIHLVTGVIRVGNAT 2131
V L EN P G +LQ+ A G + Y +E +R F I TG + ++
Sbjct: 252 VALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVST-DSV 310
Query: 2132 IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGT 2191
+DRE +E++ L V A D T P S T +T+L+ D ND P F V E+ E G
Sbjct: 311 LDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRERVRENLEVGY 370
Query: 2192 VIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRE 2249
+ I A D D +N L Y ++G D F +N ++G V ++ ++RE
Sbjct: 371 EVLTIRASDRDSPINANLRYRVLG------------GAWDVFQLNESSGVVSTRAVLDRE 418
Query: 2250 LVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGA 2309
A Y++ + D + S + A + + V D NDN PQF Y+ ++ E
Sbjct: 419 EAAEYQLLVEANDQGRNPGPLSAT---ATVYIEVEDENDNYPQFSEQN---YVVQVPEDV 472
Query: 2310 TPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLN 2369
T ++ V A D D+G N + Y++L G L S + N +D+E+V +
Sbjct: 473 GLNTAVLRVQATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVIN-PLDFEDVQKYS 531
Query: 2370 FTVRASDNGSPPRAAEIPVY-LEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATD 2428
+++A D G PP V ++++D+NDN PIF +Q V E+VP+G ++ + A D
Sbjct: 532 LSIKAQDGGRPPLINSSGVVSVQVLDVNDNEPIFVSSPFQATVLENVPLGYPVVHIQAVD 591
Query: 2429 ADSGNFALIEYSLGDGESKFA-------------------INPTTGDIYVLSSLDREKKD 2469
ADSG A + Y L D S F I+ ++G I V + LDRE+ +
Sbjct: 592 ADSGENARLHYRLVDTASTFLGGGSAGPKNPAPTPDFPFQIHNSSGWITVCAELDREEVE 651
Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI 2529
HY A D+ S +S V I VLDVND P F++P + + E+ G+SV+
Sbjct: 652 HYSFGVEAVDH----GSPPMSSSTSVSITVLDVNDNDPVFTQPTYELRLNEDAAVGSSVL 707
Query: 2530 TMMATDQDEGPNGELTYSLEGPGVE---AFHVDMDSGLVTTQRPL--QSYEKFSLTVVAT 2584
T+ A D+D N +TY L G A GL+T PL + +++ L V A+
Sbjct: 708 TLQARDRDA--NSVITYQLTGGNTRNRFALSSQRGGGLITLALPLDYKQEQQYVLAVTAS 765
Query: 2585 DGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGL 2644
DG T +L+ V D N +RPVF + + + E+ P+ +++ + A D+D G
Sbjct: 766 DGTRSH---TAHVLINVTDANTHRPVF--QSSHYTVSVSEDRPVGTSIATLSANDEDTGE 820
Query: 2645 NGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYET 2704
N + Y F IDP SG + T LD E+Q Y+L ++A D G P +T
Sbjct: 821 NARITYVIQDPVPQ-----FRIDPDSGTMYTMMELDYENQVAYTLTIMAQDNGIPQKSDT 875
Query: 2705 MQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIV 2764
L++ + D +DN P F+ + ++ E +P T + V+ A D D GPN +
Sbjct: 876 TT-LEILILDANDNAPQFLW------DFYQGSIFEDAPPSTSILQVS-ATDRDSGPNGRL 927
Query: 2765 YYFIAAGNE-EKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLD 2822
Y G++ + +F+++P G + R LDRE A+++ A S TP
Sbjct: 928 LYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPTP--------- 978
Query: 2823 LVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVF 2882
L A + E++V + DIND P F K E V + VGS + ++ A D D G N+ +
Sbjct: 979 LSASV---EIQVTILDINDNAPMFEKDELELFVEENNPVGSVVAKIRANDPDEGPNAQIM 1035
Query: 2883 YSIL 2886
Y I+
Sbjct: 1036 YQIV 1039
Score = 183 bits (465), Expect = 2e-45
Identities = 150/521 (28%), Positives = 238/521 (45%), Gaps = 33/521 (6%)
Query: 29 PFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMD-NDPLVFGVSGEEASRFFAVEPDTG-- 85
P FT ++ L ++ED VGSSV L A+D D N + + ++G FA+ G
Sbjct: 685 PVFTQPTYE--LRLNEDAAVGSSVLTLQARDRDANSVITYQLTGGNTRNRFALSSQRGGG 742
Query: 86 VVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENT 145
++ L PLD + + ++ + + SD T V I V D N + P F + Y+V + E+
Sbjct: 743 LITLALPLDYKQEQQYVLAVTASDGTRSHTAHVLINVTDANTHRPVFQSSHYTVSVSEDR 802
Query: 146 PVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTV 205
PVGT I ++A D D G + Y Q P F ID G + + ELDYE AY LT+
Sbjct: 803 PVGTSIATLSANDEDTGENARITYVIQDPVPQFRIDPDSGTMYTMMELDYENQVAYTLTI 862
Query: 206 NATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDK 265
A D + T L I+I D D P F+ Y +I+E +PP T++ ++A D+D
Sbjct: 863 MAQDNGIPQKSDT-TTLEILILDANDNAPQFLWDFYQGSIFEDAPPSTSILQVSATDRDS 921
Query: 266 GRPRGIGYTIVSGNT-NSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
G + YT G+ + F ++ SGV+ LDREN + + L V D +
Sbjct: 922 GPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAV------DRGS 975
Query: 325 PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
P+ + + + ++DINDNAP F E + + E VG ++ I+ D DE
Sbjct: 976 PTPLSASVEIQVTILDINDNAPMFEKDELELFVEENNPVG-SVVAKIRANDPDEGPNAQI 1034
Query: 385 MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYA 444
M+++ + G+ H F + + +R + LD+E R ++ L + V A
Sbjct: 1035 MYQI-VEGDMRHFFQLDLLNGD------LRAMVELDFEV--RREYVLVVQATSAPLVSRA 1085
Query: 445 KVKITLINENDNRPIFSQPLYNISLYENVTVGTS-------VLTVLATDNDAGTFGEVSY 497
V I L+++NDN P+ P + I L+ N S + + A D D ++
Sbjct: 1086 TVHILLVDQNDNPPVL--PDFQI-LFNNYVTNKSNSFPTGVIGCIPAHDPDVSDSLNYTF 1142
Query: 498 FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDG 538
++ LD TG + L LD + + DG
Sbjct: 1143 VQGNELRLLLLDPATGELQLSRDLDNNRPLEALMEVSVSDG 1183
Score = 161 bits (407), Expect = 1e-38
Identities = 120/387 (31%), Positives = 189/387 (48%), Gaps = 33/387 (8%)
Query: 2508 QFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA----FHVDMDSG 2563
+F P + +++ENEPAGT ++ + A EG ++Y +EG E F +D +G
Sbjct: 244 KFPMPNYQVALFENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATG 303
Query: 2564 LVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILH 2621
V+T L ++ E L V A D PP TT + V V D ND+ PVF +
Sbjct: 304 AVSTDSVLDRETKETHVLRVKAVDYSTPPRSATTYITVLVKDTNDHSPVFEQSEYRE--R 361
Query: 2622 IREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDR 2681
+RE + + V + A+D+D +N +RY L A W+ F ++ SG++ T LDR
Sbjct: 362 VRENLEVGYEVLTIRASDRDSPINANLRYRVLGGA----WDVFQLNESSGVVSTRAVLDR 417
Query: 2682 ESQAVYSLILVASDLGQ-PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEH 2740
E A Y L++ A+D G+ P P + + +ED +DN P F S Q ++ VPE
Sbjct: 418 EEAAEYQLLVEANDQGRNPGPLSATATVYIEVEDENDNYPQF------SEQNYVVQVPED 471
Query: 2741 SPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIF 2799
T V V A D D+G NA ++Y I +GN F+L G L V+ LD E +
Sbjct: 472 VGLNTAVLRVQ-ATDRDQGQNAAIHYSILSGNVAGQFYLHSLSGILDVINPLDFEDVQKY 530
Query: 2800 SFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDA 2859
S +KA G P ++ +++Q + D+ND P F + + A V +
Sbjct: 531 SLSIKAQDG-------GRPPLINSSGVVSVQVL-----DVNDNEPIFVSSPFQATVLENV 578
Query: 2860 KVGSELIQVLALDADIGNNSLVFYSIL 2886
+G ++ + A+DAD G N+ + Y ++
Sbjct: 579 PLGYPVVHIQAVDADSGENARLHYRLV 605
Score = 75.9 bits (185), Expect = 6e-13
Identities = 80/291 (27%), Positives = 127/291 (43%), Gaps = 30/291 (10%)
Query: 2624 EEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRES 2683
E P + + +++A EG V Y R +F ID +G + T LDRE+
Sbjct: 256 ENEPAGTLILQLHAHYTIEGEEERVSYYMEGLFDERSRGYFRIDSATGAVSTDSVLDRET 315
Query: 2684 QAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPR 2743
+ + L + A D P P + V ++D +D+ P+F + +Y+ V E+
Sbjct: 316 KETHVLRVKAVDYSTP-PRSATTYITVLVKDTNDHSPVFEQS-----EYRE-RVRENLEV 368
Query: 2744 GTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLRDLDREREAIFSFIV 2803
G V + A D D NA + Y + G + + G + LDRE A + +V
Sbjct: 369 GYEVLTIR-ASDRDSPINANLRYRVLGGAWDVFQLNESSGVVSTRAVLDREEAAEYQLLV 427
Query: 2804 KASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGS 2863
+A+ R P P L A T V + +ED ND P+F++ Y V D + +
Sbjct: 428 EANDQG-----RNPGP---LSATAT---VYIEVEDENDNYPQFSEQNYVVQVPEDVGLNT 476
Query: 2864 ELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGIL 2914
+++V A D D G N+ + YSIL S +V F + S+ GIL
Sbjct: 477 AVLRVQATDRDQGQNAAIHYSIL-----------SGNVAGQFYLHSLSGIL 516
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 395 bits (1015), Expect = e-109
Identities = 315/982 (32%), Positives = 483/982 (49%), Gaps = 58/982 (5%)
Query: 455 DNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF-----SDDPDRFSLD 509
+ P F Q Y + EN GT+VL V+A D DAG G + Y S + FS+D
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
Query: 510 KDTGLIMLIARLDYELIQRFTLTIIARDGGGEE--TTGRVRINVLDVNDNVPTFQKDAYV 567
+GLI A LD E ++R L + A+D G T V + V D ND+ P F++ Y
Sbjct: 380 PQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYR 439
Query: 568 GALRENEPSVTQLVRLRATDEDSPPNNQITYSIV----SASAFGSYFDISLYEGYGVISV 623
LREN +++LRATD D+PPN + Y V + +A + F+I G+IS
Sbjct: 440 ETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEID--PRSGLIST 497
Query: 624 SRPLDYEQISNGLIYLTVMAMDAGNP--PLNSTVPVTIEVFDENDNPPTFSKPAYFVSVV 681
S +D E + + L V A D G P ++TV V I V DENDN P FS+ Y V
Sbjct: 498 SGRVDREHMES--YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVR 555
Query: 682 ENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSE 741
E++ VL + ATD D+ I S F I++ +GEI + LD E + E
Sbjct: 556 EDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE 615
Query: 742 YILIVRAVDGG-VGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTV 800
Y L +RA D G + TG+A++ + +DIND+ P + P+ ++++E P V +
Sbjct: 616 YALRIRAQDAGRPPLSNNTGLASIQV--VDINDHIPIFVSTPFQVSVLENAPLGHSVIHI 673
Query: 801 VAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVV 858
AVD D GEN L YS+ P+ + +NS TG + + LDRE+ + + V
Sbjct: 674 QAVDADHGENARLEYSLTGVAPDTPFVINSATGWV-SVSGPLDRESVEHY------FFGV 726
Query: 859 SVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLD 918
D G PPL A++S TV V LD+NDN P F + + E G S+ V A+D D
Sbjct: 727 EARDHGSPPLSASASVTVTV--LDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD 784
Query: 919 EGLNGLVSYRMPVGMPRMDFLINSSSGV--VVTTTELDRERIAEYQLRVVASDAGTPTKS 976
N +SY++ G R F I++ GV V LD ++ ++L + ASD
Sbjct: 785 --ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRAL---H 839
Query: 977 STSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITG 1036
+ I++ D N P F A Y+VSV+ED P +V ++ +D+DVG NA ++Y +
Sbjct: 840 DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED 899
Query: 1037 GNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVN 1096
+F + + LD E Y L + A DNG K T V V V DVN
Sbjct: 900 NL--PQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQK--ADTTYVEVMVNDVN 955
Query: 1097 DNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGN-NFRIHVS 1155
DN P F+ S Y V ED P S+LQ+ ATD D GRV Y +G G+ +F I +
Sbjct: 956 DNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPT 1015
Query: 1156 NGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSR 1215
+G ++R R LDRE S + L A + + P+R+ V + V V+D+ND APVF +++
Sbjct: 1016 SG-IVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEF-E 1073
Query: 1216 LGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYE 1274
+ ++E + +G+ V + A D D G + Y+I+ G F++D +G + + LDYE
Sbjct: 1074 VRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYE 1133
Query: 1275 TKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN-----ASYEAAILENLALG 1329
+ Y++ V AT AP ++ +V++ L+++ D + +N +Y + + G
Sbjct: 1134 ARQEYVIVVQAT-SAPLVSR--ATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSG 1190
Query: 1330 TEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV 1389
I R+ AY D + + Y F Q L ++ +G + + +D + ++ V
Sbjct: 1191 I-IGRIPAYDPDVSDHLFYSFERGNELQ---LLVVNQTSGELRLSRKLDNNRPLVASMLV 1246
Query: 1390 VADDGGPKVDSTVKVYITVLDE 1411
DG V + + + ++ E
Sbjct: 1247 TVTDGLHSVTAQCVLRVVIITE 1268
Score = 385 bits (990), Expect = e-106
Identities = 290/944 (30%), Positives = 458/944 (48%), Gaps = 47/944 (4%)
Query: 559 PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY 618
P F + Y + ENE + T ++R+ A D D+ ++ YS+ + S S+
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 619 GVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFV 678
G+I + LD E + YL V A D G+P L++T V + V D ND+ P F + Y
Sbjct: 383 GLIRTAAALDRESMERH--YLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRE 440
Query: 679 SVVENIMAGATVLFLNATDLD-------RSREYGQESIIYSLEGSTQFRINARSGEITTT 731
++ EN+ G +L L ATD D R R G + + F I+ RSG I+T+
Sbjct: 441 TLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAA--RAAAAAAFEIDPRSGLISTS 498
Query: 732 SLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
+DRE Y L+V A D G ++ V+IT+LD NDN P + + Y + E
Sbjct: 499 GRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDV 558
Query: 792 PPDSDVTTVVAVDPDLGENGTLVYSIQPPNK--FYSLNSTTGKIRTTHAMLDRENPDPHE 849
P + V V A D D NG + Y+I N ++++S TG+I+ A LD E
Sbjct: 559 RPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVV-APLD------FE 611
Query: 850 AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSI 909
AE + + D GRPPL + ++ + ++D+ND+ P F + PF VLE P G S+
Sbjct: 612 AEREYALRIRAQDAGRPPL-SNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV 670
Query: 910 YQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD 969
+ A+D D G N + Y + P F+INS++G V + LDRE + Y V A D
Sbjct: 671 IHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
Query: 970 AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAE 1029
G+P S+++++T+ VLDVND P F Y++ ++ED VV + D D N+
Sbjct: 731 HGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSA 788
Query: 1030 LSYFITGGNVDGKFSVGYRDAV--VRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTAT 1087
+SY ITGGN +F++ + V V + LD + + L+L A D +
Sbjct: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD-----RALHDHCY 843
Query: 1088 VFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHG 1147
V + + D N +RP+F + Y SV ED P G +I+ + A+D D GE R+ Y L ++
Sbjct: 844 VHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITY--LLEDNL 901
Query: 1148 NNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPV 1207
FRI +G + PLD E ++ L + A ++ + + V V V D+ND AP
Sbjct: 902 PQFRIDADSGAITL-QAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQ 960
Query: 1208 FTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG--AEGKFEIDESTGLI 1265
F Y+ L + E A TSV+ + ATDRD+ G V Y +G +G F I+ ++G++
Sbjct: 961 FVASHYTGL-VSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIV 1019
Query: 1266 ITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILEN 1325
TV LD E + Y + A D+ P + S+ + + + D A F +E + EN
Sbjct: 1020 RTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKEN 1079
Query: 1326 LALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFY 1385
+G+ + ++ A D + LF++D +G +T +D E Y
Sbjct: 1080 SIVGSVVAQITAVDPDE-GPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEY 1138
Query: 1386 TLTVVADDGGPKVDSTVKVYITVLDENDNSP---RFDFTSDSAVSIPEDCPVGQRVATVK 1442
+ V A P V S V++ ++D+NDNSP F ++ VS D + +
Sbjct: 1139 VIVVQA-TSAPLV-SRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDTFPSGIIGRIP 1196
Query: 1443 AWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLD 1486
A+DPD + + +S GN +++ N + GE+ ++R LD
Sbjct: 1197 AYDPDVSDH--LFYSFERGN---ELQLLVVNQTSGELRLSRKLD 1235
Score = 380 bits (977), Expect = e-105
Identities = 295/959 (30%), Positives = 462/959 (48%), Gaps = 70/959 (7%)
Query: 1531 FGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA---FRMDRISGEIAT 1587
+ Y V EN GTAV++V A D D G L Y + + F +D SG I T
Sbjct: 328 YNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRT 387
Query: 1588 RPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGP 1647
A DRE ++L T +D G+P LSATT V VT+ D ND++P+F+Q Y L E
Sbjct: 388 AAAL-DRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETLRENV 446
Query: 1648 DTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNT-----FRIDRHMGVITAAKELDYEI 1702
+ ++ ++A D D PN + Y V F ID G+I+ + +D E
Sbjct: 447 EE-GYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREH 505
Query: 1703 SHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR 1762
Y L+V A+DQ R ++T V + V D NDN P F + +P
Sbjct: 506 MES-YELVVEASDQGQEPGPR-SATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTV 563
Query: 1763 VWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRK--DVELDRETIAFYNLT 1820
V A DRD NG V Y+I+ G+ G F I + G ++V D E +RE Y L
Sbjct: 564 VLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAERE----YALR 619
Query: 1821 ICARDRGMPPLSS-TMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
I A+D G PPLS+ T L I+V+DIND+ P+ ++ P +++ EN+P+ V H+ A DAD
Sbjct: 620 IRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679
Query: 1880 SGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIAR 1939
G NARL +++T + F IN+ TG V+V+ PLDRE + Y + +D+ P A
Sbjct: 680 HGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSAS 739
Query: 1940 RDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVT 1999
+ ++ D NDN P FT Y + E++ GT + + D+D + ++
Sbjct: 740 ASVTVTVL---DVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTA------VDRDANSAIS 790
Query: 2000 YQLLGAQS-GLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLIT 2058
YQ+ G + F I++ GV V + +D + +L+L A D L+ ++ I
Sbjct: 791 YQITGGNTRNRFAISTQGGVGLVTLALPLDYK--QERYFKLVLTASD-RALHDHCYVHIN 847
Query: 2059 ILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLI 2118
I D N +RP F A +V + E+ P G +++ ++A+D+D G N + Y +E +F I
Sbjct: 848 ITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLEDNL-PQFRI 906
Query: 2119 HLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPI 2178
+G I + A +D E+Q +Y L + A D G + T V ++++D+ND+ P+F+
Sbjct: 907 DADSGAITL-QAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFVASH 965
Query: 2179 QTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDA---FAV 2233
T V E A P T + I+A D D N +++Y N ED F +
Sbjct: 966 YTGLVSEDAPPFTSVLQISATDRDAHANGRVQY-------------TFQNGEDGDGDFTI 1012
Query: 2234 NINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF 2293
+G V ++RE V+ YE+T +D VS+ V V DVNDN P F
Sbjct: 1013 EPTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSI-----QVMVQDVNDNAPVF 1067
Query: 2294 KPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGK 2353
+ R+ E + G+ + + AVDPD+G N + Y +++ P Q+ D +G+
Sbjct: 1068 P---AEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQM-DIFSGE 1123
Query: 2354 VIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ-----PSYQ 2408
+ A +DYE V+A+ S P + V++ +VD NDN+P+ + +Y
Sbjct: 1124 LTALIDLDYEARQEYVIVVQAT---SAPLVSRATVHVRLVDQNDNSPVLNNFQILFNNYV 1180
Query: 2409 EAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREK 2467
+ P G II + A D D + + G+ +N T+G++ + LD +
Sbjct: 1181 SNRSDTFPSG-IIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNNR 1238
Score = 380 bits (976), Expect = e-104
Identities = 282/874 (32%), Positives = 433/874 (49%), Gaps = 67/874 (7%)
Query: 1954 DNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG----L 2009
+ HP F + YQ V EN AGT + ++A D D + Y L + L
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAGTAVL----RVVAQDPDAGEAGRLVYSLAALMNSRSLEL 375
Query: 2010 FDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTF 2069
F I+ +G+ +R+ +DRE+ L + L++T + +T+ D ND+ P F
Sbjct: 376 FSIDPQSGL--IRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVF 433
Query: 2070 SPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI------EAGAQDRFLIHLVTG 2123
A L EN G+ +LQ+ ATD D+ N L YR A A F I +G
Sbjct: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSG 493
Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTV--PLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
+I + +DRE ESY L V A+D+G P S T V I + D ND+ P+F
Sbjct: 494 LIST-SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVA 552
Query: 2182 SVLESAEPGTVIANITAIDH--DLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
V E P TV+ +TA D D N + Y+I+ N FA++ TG
Sbjct: 553 QVREDVRPHTVVLRVTATDRDKDANGLVHYNIIS-----------GNSRGHFAIDSLTGE 601
Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
+ V +P++ E Y + + A D +S ++ V+D+ND+ P F T
Sbjct: 602 IQVVAPLDFEAEREYALRI----RAQDAGRPPLSNNTGLASIQVVDINDHIPIFVS---T 654
Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 2359
+ +LE A G ++I + AVD D G N + Y+L + P + +S+ G V +
Sbjct: 655 PFQVSVLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVI-NSATGWVSVSGP 713
Query: 2360 VDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGT 2419
+D E V F V A D+GSPP +A V + ++D+NDN P F Y + ED VGT
Sbjct: 714 LDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGT 773
Query: 2420 IILTVTATDADSGNFALIEYSLGDGESKFAINPT--TGDIYVLSSLDREKKDHYILTALA 2477
+++VTA D D+ + + + G+ ++FAI+ G + + LD +++ ++ L A
Sbjct: 774 SVVSVTAVDRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTA 833
Query: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD 2537
D + V I + D N RP F +S SV E+ P G++++ + A+D D
Sbjct: 834 SD-------RALHDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDD 886
Query: 2538 EGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTT 2595
G N +TY LE + F +D DSG +T Q PL ++ ++L + A D G P TT
Sbjct: 887 VGENARITYLLE-DNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTT 945
Query: 2596 MLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLK- 2654
+ V V DVNDN P FV + + E+ P ++V ++ ATD+D NG V+Y+F
Sbjct: 946 YVEVMVNDVNDNAPQFVASHYTGL--VSEDAPPFTSVLQISATDRDAHANGRVQYTFQNG 1003
Query: 2655 TAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALED 2714
G+ D F I+P SG+++T +RLDRE+ +VY L A D G P P T +QV ++D
Sbjct: 1004 EDGDGD---FTIEPTSGIVRTVRRLDREAVSVYELTAYAVDRGVP-PLRTPVSIQVMVQD 1059
Query: 2715 IDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEE 2774
++DN P+F + +++ + V E+S G++V +T AVD DEGPNA + Y I GN
Sbjct: 1060 VNDNAPVF-----PAEEFE-VRVKENSIVGSVVAQIT-AVDPDEGPNAHIMYQIVEGNIP 1112
Query: 2775 KNFHLQP-DGCLLVLRDLDREREAIFSFIVKASS 2807
+ F + G L L DLD E + +V+A+S
Sbjct: 1113 ELFQMDIFSGELTALIDLDYEARQEYVIVVQATS 1146
Score = 370 bits (949), Expect = e-101
Identities = 293/918 (31%), Positives = 451/918 (49%), Gaps = 71/918 (7%)
Query: 1428 IPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDR 1487
+PE+ G V V A DPDAG G++V+SLA+ + + E+ + + G + A LDR
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
Query: 1488 EELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
E ++ + L+V A D G+P ++ VT+ D ND+ PV E Y ++ ENV G +
Sbjct: 394 ESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQA-QYRETLRENVEEGYPI 452
Query: 1548 VQVRATDRDIGINSVLSYYI-----TEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHL 1602
+Q+RATD D N+ L Y AF +D SG I+T DRE Y L
Sbjct: 453 LQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST-SGRVDREHMESYEL 511
Query: 1603 VATVEDEGTP--TLSATTHVYVTIVDENDNAPMFQQPHY--EVLLDEGPDTLNTSLITIQ 1658
V D+G SAT V++T++DENDNAP F + Y +V D P T+ ++ +
Sbjct: 512 VVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTV---VLRVT 568
Query: 1659 ALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQ-C 1717
A D D+ NG V Y I++GN F ID G I LD+E + Y L + A D
Sbjct: 569 ATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFE-AEREYALRIRAQDAGR 627
Query: 1718 PILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVT--EGQP-GPRVWTFLAHDRDSG 1774
P LS+ +T + V DIND++P F PF+V+ E P G V A D D G
Sbjct: 628 PPLSN---NTGLASIQVVDINDHIPIF---VSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
Query: 1775 PNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSST 1834
N ++EYS+ P FVI+ G + V LDRE++ Y + ARD G PPLS++
Sbjct: 682 ENARLEYSLTGVAPDTPFVINSATGWVSV--SGPLDRESVEHYFFGVEARDHGSPPLSAS 739
Query: 1835 MLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGN 1894
V + VLD+NDN P ++ ++E++ V + V V A D D+ N+ +++ IT GN
Sbjct: 740 ASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAISYQITGGN 797
Query: 1895 RERAFFINAT--TGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDE 1952
F I+ G+VT+ PLD ++ +KL ++ D A D+ + I ++D
Sbjct: 798 TRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDR------ALHDHCYVHINITDA 851
Query: 1953 NDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDI 2012
N + P+F + Y V E+ P G+ + V++ A D D A +TY LL F I
Sbjct: 852 NTHRPVFQSAHYSVSVNEDRPMGSTIVVIS----ASDDDVGENARITY-LLEDNLPQFRI 906
Query: 2013 NSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLN--STAHLLITILDDNDNRPTFS 2070
++ +G +T+++ + + + L + A D G+ T ++ + + D NDN P F
Sbjct: 907 DADSGAITLQAPLDYEDQV----TYTLAITARDNGIPQKADTTYVEVMVNDVNDNAPQFV 962
Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG--AQDRFLIHLVTGVIRVG 2128
+ T + E+ PP SVLQ++ATD D+ NG + Y + G F I +G++R
Sbjct: 963 ASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTV 1022
Query: 2129 NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAE 2188
+DRE Y LT A DRG PL + +++ D+ND+ P F V V E++
Sbjct: 1023 R-RLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKENSI 1081
Query: 2189 PGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNR 2248
G+V+A ITA+D D P HI+ + + N + F ++I +G + ++
Sbjct: 1082 VGSVVAQITAVDPDEGPNA--HIMYQIVEG-------NIPELFQMDIFSGELTALIDLDY 1132
Query: 2249 ELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITY--YMERIL 2306
E Y + + A+ P V A + V ++D NDN+P F I + Y+
Sbjct: 1133 EARQEYVIVV----QATSAP----LVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSN-R 1183
Query: 2307 EGATPGTTLIAVAAVDPD 2324
P + + A DPD
Sbjct: 1184 SDTFPSGIIGRIPAYDPD 1201
Score = 362 bits (930), Expect = 3e-99
Identities = 279/883 (31%), Positives = 423/883 (47%), Gaps = 48/883 (5%)
Query: 346 PEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSV 405
P+F Y + E G A+ ++VV +D + G VY + + + S+
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAV---LRVVAQDPDAGEAGRL-VYSLAALMNSRSLELFSI 378
Query: 406 QGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPL 464
++ + IR A LD E+++R+ + A + P V +T+ + ND+ P+F Q
Sbjct: 379 DPQSGL-IRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 465 YNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP-------DRFSLDKDTGLIML 517
Y +L ENV G +L + ATD DA + Y F P F +D +GLI
Sbjct: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Query: 518 IARLDYELIQRFTLTIIARDGGGE----ETTGRVRINVLDVNDNVPTFQKDAYVGALREN 573
R+D E ++ + L + A D G E T RV I VLD NDN P F + YV +RE+
Sbjct: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
Query: 574 EPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQIS 633
T ++R+ ATD D N + Y+I+S ++ G + SL G I V PLD+E +
Sbjct: 558 VRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSL---TGEIQVVAPLDFE--A 612
Query: 634 NGLIYLTVMAMDAGNPPL-NSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLF 692
L + A DAG PPL N+T +I+V D ND+ P F + VSV+EN G +V+
Sbjct: 613 EREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIH 672
Query: 693 LNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGG 752
+ A D D E + + T F IN+ +G ++ + LDRE+ Y V A D
Sbjct: 673 IQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDH- 731
Query: 753 VGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGT 812
G + A+V +T+LD+NDN P + Y++ L E + V +V AVD D N
Sbjct: 732 -GSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD--ANSA 788
Query: 813 LVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 870
+ Y I N +++++ G T A+ P ++ E K+V++ +D
Sbjct: 789 ISYQITGGNTRNRFAISTQGGVGLVTLAL-----PLDYKQERYFKLVLTASD-----RAL 838
Query: 871 TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930
V +N+ D N + P FQ+ + V E P G +I + A D D G N ++Y +
Sbjct: 839 HDHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE 898
Query: 931 VGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVND 990
+P+ F I++ SG + LD E Y L + A D G P K+ T+ + + V DVND
Sbjct: 899 DNLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVND 956
Query: 991 ETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSY-FITGGNVDGKFSVGYRD 1049
P F + Y VSED P V+ ++ TD D N + Y F G + DG F++
Sbjct: 957 NAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTS 1016
Query: 1050 AVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEA 1109
+VRTV LDRE + Y L A+D G R ++ V V DVNDN P+F +E
Sbjct: 1017 GIVRTVRRLDREAVSVYELTAYAVDRGVPPLR--TPVSIQVMVQDVNDNAPVFPAEEFEV 1074
Query: 1110 SVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRE 1169
V E+ G + Q+ A D DEG + Y+I+ GN F++ + +G L LD E
Sbjct: 1075 RVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGEL-TALIDLDYE 1133
Query: 1170 RNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQ 1212
+V++V+A + P+ S V V + D ND +PV Q
Sbjct: 1134 ARQEYVIVVQATS---APLVSRATVHVRLVDQNDNSPVLNNFQ 1173
Score = 362 bits (928), Expect = 4e-99
Identities = 319/1059 (30%), Positives = 504/1059 (47%), Gaps = 89/1059 (8%)
Query: 1860 ISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERA---FFINATTGIVTVNRPLDR 1916
+ EN + V V+A D D+G RL +++ A R+ F I+ +G++ LDR
Sbjct: 334 VPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGLIRTAAALDR 393
Query: 1917 ERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT 1976
E + + L ++ +D+ +PR++ ++ + ++D ND+ P+F ++ Y+ + EN G
Sbjct: 394 ESMERHYLRVTAQDHG-SPRLSATT--MVAVTVADRNDHSPVFEQAQYRETLRENVEEGY 450
Query: 1977 PLTVLNGPILALDADQDIYAVVTYQLLG------AQSGLFDINSSTGVVTVRSGVIIDRE 2030
P+ L A D D A + Y+ +G A + F+I+ +G+++ V DRE
Sbjct: 451 PILQLR----ATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV--DRE 504
Query: 2031 AFSPPILELLLLAEDIGL----LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGF 2086
EL++ A D G ++T + IT+LD+NDN P FS + E+ P
Sbjct: 505 HMES--YELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHT 562
Query: 2087 SVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVV 2145
VL+VTATD D NG + Y I +G ++ F I +TG I+V A +D E + Y L +
Sbjct: 563 VVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVV-APLDFEAEREYALRIR 621
Query: 2146 ATDRGTVPLSG-TAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAID--HD 2202
A D G PLS T + +I + DIND P F++ VSVLE+A G + +I A+D H
Sbjct: 622 AQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHG 681
Query: 2203 LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVID 2262
N +LEY + G+ + F +N TG V V P++RE V Y + D
Sbjct: 682 ENARLEYSLTGVAP-----------DTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD 730
Query: 2263 NASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVD 2322
+ S P S S A +TV VLDVNDN P+F + Y R+ E A GT++++V AVD
Sbjct: 731 HGS--PPLSAS---ASVTVTVLDVNDNRPEFT---MKEYHLRLNEDAAVGTSVVSVTAVD 782
Query: 2323 PDKGLNGLVTYTLLDLVPPGYVQLE-DSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPP 2381
D N ++Y + + G V +DY++ + + ASD
Sbjct: 783 RDA--NSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHD 840
Query: 2382 RAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL 2441
V++ I D N + P+F Y +V ED P+G+ I+ ++A+D D G A I Y L
Sbjct: 841 HCY---VHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL 897
Query: 2442 GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLD 2501
D +F I+ +G I + + LD E + Y L A+DN ++ ++ V + V D
Sbjct: 898 EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDN----GIPQKADTTYVEVMVND 953
Query: 2502 VNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEG--PGVEAFHVD 2559
VND PQF ++ V E+ P TSV+ + ATD+D NG + Y+ + G F ++
Sbjct: 954 VNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIE 1013
Query: 2560 MDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNG 2617
SG+V T R L ++ + LT A D G PPL + V V DVNDN PVF P
Sbjct: 1014 PTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVF--PAEE 1071
Query: 2618 TILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQ 2677
+ ++E + S V ++ A D DEG N + Y ++ GN E F +D SG +
Sbjct: 1072 FEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVE--GNIP-ELFQMDIFSGELTALI 1128
Query: 2678 RLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTV 2737
LD E++ Y +++ A+ P + + V L D +DN P+ +Q+L
Sbjct: 1129 DLDYEARQEYVIVVQATS----APLVSRATVHVRLVDQNDNSPVL-------NNFQILFN 1177
Query: 2738 PEHSPRG-TLVGNVTGAVDA-DEGPNAIVYYFIAAGNEEKNFHL-QPDGCLLVLRDLDRE 2794
S R T + G + A D + ++Y GNE + + Q G L + R LD
Sbjct: 1178 NYVSNRSDTFPSGIIGRIPAYDPDVSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDNN 1237
Query: 2795 REAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTK---AEY 2851
R + S +V + + + + +L + V LE++ + RF +
Sbjct: 1238 RPLVASMLVTVTDGLHSVTAQCVLRVVIITEELLANSLTVRLENMWQE--RFLSPLLGRF 1295
Query: 2852 TAGVATDAKVGSELIQVLAL--DADIGNNSL-VFYSILA 2887
GVA +E + + + D D+G L V +S LA
Sbjct: 1296 LEGVAAVLATPAEDVFIFNIQNDTDVGGTVLNVSFSALA 1334
Score = 348 bits (893), Expect = 5e-95
Identities = 281/905 (31%), Positives = 449/905 (49%), Gaps = 86/905 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASRF-----FAVEPDTGVVWLRQPL 93
+ E+ G + QL A D D P L + G A+R F ++P +G++ +
Sbjct: 442 LRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRV 501
Query: 94 DRETKSEFTVEFSVSDHQGV------ITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPV 147
DRE + + SD QG T +V+I V D NDNAP F + Y ++ E+
Sbjct: 502 DREHMESYELVVEASD-QGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRP 560
Query: 148 GTPIFIVNATDPDLGAGGSVLYSFQPPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTV 205
T + V ATD D A G V Y+ + FAIDS G + V+ LD+E + Y L +
Sbjct: 561 HTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAEREYALRI 620
Query: 206 NATDQDKTRPLSTLANLAII-ITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
A D + PLS LA I + D+ D PIF++ P+ ++ E++P G +V I A+D D
Sbjct: 621 RAQDAGRP-PLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDAD 679
Query: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRT 324
G + Y++ ++ F ++ +G ++++G LDRE+ H F G E D +
Sbjct: 680 HGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRES--VEHYFF----GVEARDHGS 733
Query: 325 P---SDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLG 381
P + A+VT T V+D+NDN PEF EY + + E A VG ++ + + VD+D N
Sbjct: 734 PPLSASASVTVT----VLDVNDNRPEFTMKEYHLRLNEDAAVGTSV-VSVTAVDRDANSA 788
Query: 382 LNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDH 440
++ GN + F I S QG + + +A+PLDY+ + L A++ ++ DH
Sbjct: 789 ISYQI---TGGNTRNRFAI---STQGGVGL-VTLALPLDYKQERYFKLVLTASDRALHDH 841
Query: 441 VGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS 500
V I + + N +RP+F Y++S+ E+ +G++++ + A+D+D G ++Y
Sbjct: 842 ---CYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE 898
Query: 501 DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNV 558
D+ +F +D D+G I L A LDYE +TL I ARD G + T V + V DVNDN
Sbjct: 899 DNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNA 958
Query: 559 PTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGY 618
P F Y G + E+ P T ++++ ATD D+ N ++ Y+ + D ++
Sbjct: 959 PQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDG--DFTIEPTS 1016
Query: 619 GVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFV 678
G++ R LD E +S + LT A+D G PPL + V + + V D NDN P F + V
Sbjct: 1017 GIVRTVRRLDREAVS--VYELTAYAVDRGVPPLRTPVSIQVMVQDVNDNAPVFPAEEFEV 1074
Query: 679 SVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQ--FRINARSGEITTTSLLD 735
V EN + G+ V + A D D E I+Y + EG+ F+++ SGE+T LD
Sbjct: 1075 RVKENSIVGSVVAQITAVDPD---EGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLD 1131
Query: 736 RETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPY----YINLVEMT 791
E + EY+++V+A + ATV++ L+D NDN P + Y++ T
Sbjct: 1132 YEARQEYVIVVQATSAPL-----VSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRSDT 1186
Query: 792 PPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSL--NSTTGKIRTTHAMLDRENPDPHE 849
P + + A DPD+ ++ L YS + N+ L N T+G++R + LD P
Sbjct: 1187 FPSGIIGRIPAYDPDVSDH--LFYSFERGNELQLLVVNQTSGELRLSR-KLDNNRP---- 1239
Query: 850 AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT--FQNL-------PFVAEVL 900
L+ ++V+VTD G + A V + +L N T +N+ P + L
Sbjct: 1240 --LVASMLVTVTD-GLHSVTAQCVLRVVIITEELLANSLTVRLENMWQERFLSPLLGRFL 1296
Query: 901 EGIPA 905
EG+ A
Sbjct: 1297 EGVAA 1301
Score = 335 bits (859), Expect = 4e-91
Identities = 292/996 (29%), Positives = 463/996 (46%), Gaps = 76/996 (7%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVTQLLAQDMDNDP---LVFGVSGEEASR---FFA 79
NR P F + + T L+ E+ G++V +++AQD D LV+ ++ SR F+
Sbjct: 320 NRHPQFPQYNYQT--LVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFS 377
Query: 80 VEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGV---ITRKVNIQVGDVNDNAPTFHNQP 136
++P +G++ LDRE+ + + DH T V + V D ND++P F
Sbjct: 378 IDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQ 437
Query: 137 YSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPP-------SQFFAIDSARGIVTV 189
Y + EN G PI + ATD D ++ Y F P + F ID G+++
Sbjct: 438 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLIST 497
Query: 190 IRELDYETTQAYQLTVNATDQ-DKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEH 248
+D E ++Y+L V A+DQ + P S + I + D D P F Y + E
Sbjct: 498 SGRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVRED 557
Query: 249 SPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSH 308
P T V +TA D+DK + Y I+SGN+ FA+D ++G + + LD E
Sbjct: 558 VRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFE---AER 614
Query: 309 GFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALP 368
+ L ++ D P + T +I V+DIND+ P F S+ + V++ E A +G ++
Sbjct: 615 EYALRIRA---QDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSV- 670
Query: 369 LFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTS--VQGKADIRIRVAIPLDYETVDR 426
+ IQ VD D G N+ E L G ++P + V A + V+ PLD E+V+
Sbjct: 671 IHIQAVDADH--GENARLEYSLTG-------VAPDTPFVINSATGWVSVSGPLDRESVEH 721
Query: 427 YDFDLFANE-SVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLAT 485
Y F + A + P A V +T+++ NDNRP F+ Y++ L E+ VGTSV++V A
Sbjct: 722 YFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781
Query: 486 DNDAGTFGEVSYFFSDDPDRFSLDKD--TGLIMLIARLDYELIQRFTLTIIARDGGGEET 543
D DA + + +RF++ GL+ L LDY+ + F L + A D +
Sbjct: 782 DRDANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDH 841
Query: 544 TGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSA 603
V IN+ D N + P FQ Y ++ E+ P + +V + A+D+D N +ITY +
Sbjct: 842 C-YVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLED- 899
Query: 604 SAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFD 663
+ + G I++ PLDYE L + A D G P T V + V D
Sbjct: 900 ----NLPQFRIDADSGAITLQAPLDYE--DQVTYTLAITARDNGIPQKADTTYVEVMVND 953
Query: 664 ENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLD-RSREYGQESIIYSLEGSTQFRIN 722
NDN P F Y V E+ +VL ++ATD D + Q + +G F I
Sbjct: 954 VNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIE 1013
Query: 723 ARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAP 782
SG + T LDRE S Y L AVD GV + ++ + + D+NDN P +
Sbjct: 1014 PTSGIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTP--VSIQVMVQDVNDNAPVFPAEE 1071
Query: 783 YYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAML 840
+ + + E + S V + AVDPD G N ++Y I N + + ++ +G++ A++
Sbjct: 1072 FEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELT---ALI 1128
Query: 841 DRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLP-----F 895
D + +EA IVV T PL S ATV V L+D NDN P N +
Sbjct: 1129 DLD----YEARQEYVIVVQATSA---PL--VSRATVHVRLVDQNDNSPVLNNFQILFNNY 1179
Query: 896 VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDR 955
V+ + P+G+ I ++ A D D ++ + Y G ++N +SG + + +LD
Sbjct: 1180 VSNRSDTFPSGI-IGRIPAYDPD--VSDHLFYSFERGNELQLLVVNQTSGELRLSRKLDN 1236
Query: 956 ERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDE 991
R + V +D S T+ + V+ + +E
Sbjct: 1237 NRPLVASMLVTVTDG---LHSVTAQCVLRVVIITEE 1269
Score = 320 bits (820), Expect = 1e-86
Identities = 258/839 (30%), Positives = 394/839 (46%), Gaps = 67/839 (7%)
Query: 2064 DNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDR----FLIH 2119
+ P F + EN G +VL+V A D D+G G LVY + A R F I
Sbjct: 320 NRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
Query: 2120 LVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
+G+IR A +DRE E + L V A D G+ LS T +V + + D ND P F
Sbjct: 380 PQSGLIRTA-AALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQY 438
Query: 2180 TVSVLESAEPGTVIANITAIDHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINT 2237
++ E+ E G I + A D D N L Y VG A AF ++ +
Sbjct: 439 RETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAA------AAAAFEIDPRS 492
Query: 2238 GSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFG 2297
G + ++RE + +YE+ + D + RS +V ++ + VLD NDN PQF
Sbjct: 493 GLISTSGRVDREHMESYELVVEASDQGQEPGPRSATV---RVHITVLDENDNAPQFSE-- 547
Query: 2298 ITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIAN 2357
Y+ ++ E P T ++ V A D DK NGLV Y ++ G+ + DS G++
Sbjct: 548 -KRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAI-DSLTGEIQVV 605
Query: 2358 RTVDYEEVHWLNFTVRASDNGSPPRAAEIPV-YLEIVDINDNNPIFDQPSYQEAVFEDVP 2416
+D+E +RA D G PP + + +++VDIND+ PIF +Q +V E+ P
Sbjct: 606 APLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAP 665
Query: 2417 VGTIILTVTATDADSGNFALIEYSLGD--GESKFAINPTTGDIYVLSSLDREKKDHYILT 2474
+G ++ + A DAD G A +EYSL ++ F IN TG + V LDRE +HY
Sbjct: 666 LGHSVIHIQAVDADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFG 725
Query: 2475 ALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMAT 2534
A+D+ S S V + VLDVND RP+F+ ++ + E+ GTSV+++ A
Sbjct: 726 VEARDH----GSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAV 781
Query: 2535 DQDEGPNGELTYSLEGPGVE---AFHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEP 2589
D+D N ++Y + G A GLVT PL ++ F L + A+D
Sbjct: 782 DRD--ANSAISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRA-- 837
Query: 2590 PLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVR 2649
L + + + D N +RPVF + + E+ P+ S + + A+D D G N +
Sbjct: 838 -LHDHCYVHINITDANTHRPVFQSAHYS--VSVNEDRPMGSTIVVISASDDDVGENARIT 894
Query: 2650 YSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQ 2709
Y + F ID SG I LD E Q Y+L + A D G P +T ++
Sbjct: 895 YLL-----EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTY-VE 948
Query: 2710 VALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIA 2769
V + D++DN P FV + Y L V E +P T V ++ A D D N V Y
Sbjct: 949 VMVNDVNDNAPQFV-----ASHYTGL-VSEDAPPFTSVLQIS-ATDRDAHANGRVQYTFQ 1001
Query: 2770 AGNE-EKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADL 2827
G + + +F ++P G + +R LDRE +++ A +R P R P
Sbjct: 1002 NGEDGDGDFTIEPTSGIVRTVRRLDREAVSVYELTAYA-VDRGVPPLRTP---------- 1050
Query: 2828 TLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
++V+++D+ND P F E+ V ++ VGS + Q+ A+D D G N+ + Y I+
Sbjct: 1051 --VSIQVMVQDVNDNAPVFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIV 1107
Score = 171 bits (433), Expect = 1e-41
Identities = 136/392 (34%), Positives = 193/392 (49%), Gaps = 31/392 (7%)
Query: 2507 PQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL----EGPGVEAFHVDMDS 2562
PQF + + T V ENE AGT+V+ ++A D D G G L YSL +E F +D S
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQS 382
Query: 2563 GLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
GL+ T L +S E+ L V A D G P L TTM+ V V D ND+ PVF + L
Sbjct: 383 GLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQAQYRETL 442
Query: 2621 HIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNR--DWEFFIIDPISGLIQTAQR 2678
RE + + ++ ATD D N +RY F+ R F IDP SGLI T+ R
Sbjct: 443 --RENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGR 500
Query: 2679 LDRESQAVYSLILVASDLGQ-PVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTV 2737
+DRE Y L++ ASD GQ P P + + + D +DN P F S + + V
Sbjct: 501 VDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQF------SEKRYVAQV 554
Query: 2738 PEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDRERE 2796
E T+V VT A D D+ N +V+Y I +GN +F + G + V+ LD E E
Sbjct: 555 REDVRPHTVVLRVT-ATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVVAPLDFEAE 613
Query: 2797 AIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVA 2856
++ ++A + PP L + L ++VV DIND P F + V
Sbjct: 614 REYALRIRAQD--AGRPP--------LSNNTGLASIQVV--DINDHIPIFVSTPFQVSVL 661
Query: 2857 TDAKVGSELIQVLALDADIGNNSLVFYSILAI 2888
+A +G +I + A+DAD G N+ + YS+ +
Sbjct: 662 ENAPLGHSVIHIQAVDADHGENARLEYSLTGV 693
Score = 47.8 bits (112), Expect = 2e-04
Identities = 54/191 (28%), Positives = 81/191 (42%), Gaps = 23/191 (12%)
Query: 2730 PQYQLLT-VPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKN---FHLQPD-GC 2784
PQY T VPE+ GT V V A D D G + Y +AA ++ F + P G
Sbjct: 326 PQYNYQTLVPENEAAGTAVLRVV-AQDPDAGEAGRLVYSLAALMNSRSLELFSIDPQSGL 384
Query: 2785 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPP 2844
+ LDRE V A + S PR + T+ V V + D ND P
Sbjct: 385 IRTAAALDRESMERHYLRVTAQDHGS---PRLSATTM----------VAVTVADRNDHSP 431
Query: 2845 RFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDV--- 2901
F +A+Y + + + G ++Q+ A D D N+ + Y + RA A + ++
Sbjct: 432 VFEQAQYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPR 491
Query: 2902 -GQVFTMGSMD 2911
G + T G +D
Sbjct: 492 SGLISTSGRVD 502
Score = 33.9 bits (76), Expect = 2.8
Identities = 19/73 (26%), Positives = 37/73 (50%), Gaps = 8/73 (10%)
Query: 2844 PRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQ 2903
P+F + Y V + G+ +++V+A D D G + YS+ A+ R+L +
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSL--------E 374
Query: 2904 VFTMGSMDGILRT 2916
+F++ G++RT
Sbjct: 375 LFSIDPQSGLIRT 387
>gi|216548385 dachsous 2 isoform 2 [Homo sapiens]
Length = 1369
Score = 360 bits (923), Expect = 2e-98
Identities = 358/1253 (28%), Positives = 530/1253 (42%), Gaps = 136/1253 (10%)
Query: 413 IRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYEN 472
IR A LD E D Y F +V+I + + ND+ P F + + E
Sbjct: 125 IRTARRLDRERRDHYSFVAATLLGA-----VVQVEIRVNDVNDHSPRFPLDSLQLDVSEL 179
Query: 473 VTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG------------------- 513
GT+ +A D DAG F Y D L KD
Sbjct: 180 SPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSD---LPKDPAGPFFQLRYRTPGPLPSPLL 236
Query: 514 ----------LIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTF 561
++L+ RLD E L I A DGG TG V + VLD NDN P F
Sbjct: 237 PGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVF 296
Query: 562 QKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSI---------VSASAFGSYFDI 612
++D Y A+RE+ ++ R+RATD D PN + YS+ A G
Sbjct: 297 EQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYF 356
Query: 613 SLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT-- 670
++ E GV+ V RPLD E + L V A D G P +TV V+I V D NDN P
Sbjct: 357 AVEELSGVVRVWRPLDRE--AQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIH 414
Query: 671 --FSKPAYFVSVVENIMAGATVLFLNATDLDRSRE------------YGQESIIYSLEGS 716
F V E G V ++ +D D E G SI SLEG
Sbjct: 415 VLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGG 474
Query: 717 TQFRINARSGE-----ITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDI 771
G + LDRE++ Y L++ A D G + T+ + + D+
Sbjct: 475 EGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD--AGSPPLSTEETLLLRVADL 532
Query: 772 NDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG------TLVYSIQPPN---- 821
ND P + Y ++ E P + V V A D D + T+V P N
Sbjct: 533 NDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSL 592
Query: 822 -----------KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 870
++++S +G I T LDRE + E +++ + D G PPL A
Sbjct: 593 QSKMVHTAECGPSFAIDSESGAISTIRT-LDREVQEAVELKVVAQ------DLGEPPLSA 645
Query: 871 TSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMP 930
T ++ V+ D+NDN+P F + A + E P G QV A D D GL G + Y +
Sbjct: 646 TCLVSITVD--DVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLY 703
Query: 931 VGMPRMD----FLINSSSGVVVTTTELDRER-IAEYQLRVVASDAGTPTKSSTSTLTIHV 985
G + F I+ G + + ++DRER A Y L V A D G S+ + + + +
Sbjct: 704 DGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG--GLSAQAFVRVDL 761
Query: 986 LDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSV 1045
DVND P F P+ Y S+S++ ++ + TD D G+ ++Y + GNV F++
Sbjct: 762 EDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTI 821
Query: 1046 GYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQS 1105
++ + L + L++ A D G G A V + + F +
Sbjct: 822 DSTTGIIYLTLPLSHLESTTLSLMVSAQDGG--GLTAVINADVTIHIFQTTLAPAEFERP 879
Query: 1106 SYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRP 1165
Y V ED+PE I +KA + ++YRI G+ G F IH G + R +P
Sbjct: 880 KYTFLVYEDVPEDSPIGTVKAREPLNSS-EPIFYRISSGDLGGKFSIHPRLGTI-RTRKP 937
Query: 1166 LDRERNSSHVLIVEAYNHDLG--PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAG 1223
LD E VL V+A LG P SS V + V D+ND P F + + + +T
Sbjct: 938 LDHETQPVVVLTVQA---QLGSAPACSSTEVNITVMDVNDNHPAFLRTS-DEIRISQTTP 993
Query: 1224 IGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNV 1283
GT++ + +A DRDSG GL+ Y I S G F ID + G++ L + + +
Sbjct: 994 PGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
Query: 1284 SATDQAPPFNQGFCSVYITL-LNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
A DQ + + + E + F + Y+ + E+L+ T++++ QA+ +
Sbjct: 1054 RAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHPLGP 1113
Query: 1343 LNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA---DDGGPKVD 1399
+ + + A+F I TG I ++ D E Y V A +DG +
Sbjct: 1114 QRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNV 1173
Query: 1400 STVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRV-ATVKAWDPDAGSNGQVVFSL 1458
ST V + V DENDNSP F D E+ PV Q V + A D D+G NGQ+++ L
Sbjct: 1174 STT-VIVRVWDENDNSP--TFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFL 1230
Query: 1459 ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTIL 1518
S + N + GE+ LDRE H+ + V+ +DRG+PPR + V++
Sbjct: 1231 LSDG-----KFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVT 1285
Query: 1519 DINDNPPVIESPF---GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT 1568
DINDN P +V V E V V A D D G N+ ++Y ++
Sbjct: 1286 DINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVS 1338
Score = 350 bits (897), Expect = 2e-95
Identities = 365/1279 (28%), Positives = 548/1279 (42%), Gaps = 150/1279 (11%)
Query: 611 DISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPT 670
D ++ G+I +R LD E+ + + L + V V I V D ND+ P
Sbjct: 115 DFHVHPDTGIIRTARRLDRERRDHYSFVAATL--------LGAVVQVEIRVNDVNDHSPR 166
Query: 671 FSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ------------ 718
F + + V E G A D D ++S +G T
Sbjct: 167 FPLDSLQLDVSELSPPGTAFRLPVAHDPDAG--------LFSTQGYTLVQPSDLPKDPAG 218
Query: 719 --FRINARSG------------------EITTTSLLDRETKSEYILIVRAVDGGVGHNQK 758
F++ R+ ++ LDRE + + L + A DGG ++
Sbjct: 219 PFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGG--RPRR 276
Query: 759 TGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI- 817
TG+ +V + +LD NDN P ++ Y + E P ++V V A D DLG NG + YS+
Sbjct: 277 TGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVR 336
Query: 818 --QPPN-----------KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCG 864
Q P ++++ +G +R LDR EA+ ++VV D G
Sbjct: 337 ARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRP-LDR------EAQAWHQLVVEARDGG 389
Query: 865 RPPLKATSSATVFVNLLDLNDNDPTFQNLPF----VAEVLEGIPAGVSIYQVVAIDLD-- 918
P AT V + +LD+NDN P L VA V EG G + +V D D
Sbjct: 390 AEPEVAT--VRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGD 447
Query: 919 ------------EGL-NGLVSYRMPVGMPRMDFLINSSSGVVVTTTE--LDRERIAEYQL 963
GL +G +S + G L GV E LDRE Y+L
Sbjct: 448 WEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYEL 507
Query: 964 RVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDND 1023
+VA+DAG+P S+ TL + V D+ND+ P F Y SVSE V+W++ +D D
Sbjct: 508 LLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDAD 567
Query: 1024 -------------------VGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTA 1064
L + S + F++ + T+ LDRE
Sbjct: 568 EAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQE 627
Query: 1065 AYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
A L + A D G + T V +TV DVNDN PIF + Y A++ E P GH LQ+
Sbjct: 628 AVELKVVAQDLGE--PPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQV 685
Query: 1125 KATDADEGEFGRVWYRILHG----NHGNNFRIHVSNGLLMRGPRPLDRERN-SSHVLIVE 1179
A+DAD G +G + Y + G FRI +G + + +DRER+ +++ L+VE
Sbjct: 686 TASDADSGLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVS-QDIDRERDPATYDLLVE 744
Query: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239
A D G + + V V +ED+ND PVF Y + + GT +I V ATD+DSG
Sbjct: 745 A--KDGGGLSAQAFVRVDLEDVNDNHPVFNPSTYV-TSISDETQPGTEIINVLATDQDSG 801
Query: 1240 DGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCS 1298
G V Y ++ G F ID +TG+I L + T+ + VSA D
Sbjct: 802 IYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINAD 861
Query: 1299 VYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQA 1358
V I + +F Y + E++ + I V+A + LN F +S
Sbjct: 862 VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR--EPLNSSEPIFYRISSGDL 919
Query: 1359 KALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRF 1418
F I G I + +D E LTV A G S+ +V ITV+D NDN P F
Sbjct: 920 GGKFSIHPRLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAF 979
Query: 1419 DFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGE 1478
TSD + I + P G + +A D D+G NG + +S+AS G F I + ++G
Sbjct: 980 LRTSDE-IRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQ-PGVFAI---DRALGV 1034
Query: 1479 VFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVN 1538
+F+ L E L + A D+G P+ +L V I +P Y V V+
Sbjct: 1035 LFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVS 1094
Query: 1539 ENVGGGTAVVQVRATDRDIG---INSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRE 1595
E++ T ++Q +A +G S L Y + F + +G I R
Sbjct: 1095 ESLSPMTQMLQTQA--HPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYES 1152
Query: 1596 RQSF-YHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSL 1654
Q++ + + A + ++G + +T V V + DENDN+P F + ++E P +
Sbjct: 1153 TQTYNFRVFAWIPEDGF-LQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-I 1210
Query: 1655 ITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTAT 1714
I A+D+D G NG + Y +++ F+++ + G + LD E G + + V T
Sbjct: 1211 GKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVALDRE-HRGHHEMTVLVT 1267
Query: 1715 DQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGP---FEVTEGQP-GPRVWTFLAHD 1770
D+ S +T V V+V DINDN P FP+ G +V EGQP V T A D
Sbjct: 1268 DRG---SPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKD 1324
Query: 1771 RDSGPNGQVEYSIMDGDPL 1789
D G N +V YS+ P+
Sbjct: 1325 PDEGNNAEVTYSVSSARPM 1343
Score = 349 bits (896), Expect = 2e-95
Identities = 361/1270 (28%), Positives = 551/1270 (43%), Gaps = 142/1270 (11%)
Query: 719 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTW 778
F ++ +G I T LDRE + Y + + G V V I + D+ND+ P +
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLGAV--------VQVEIRVNDVNDHSPRF 167
Query: 779 KDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI--------QPPNKFYSLNSTT 830
+++ E++PP + VA DPD G T Y++ P F+ L T
Sbjct: 168 PLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRT 227
Query: 831 GKIRTTHAMLDRENP-DPHEAELMR----------KIVVSVTDCGRPPLKATSSATVFVN 879
+ + +P +P + L+R ++ + D GRP + T +V +
Sbjct: 228 PGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRP--RRTGLLSVELR 285
Query: 880 LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGM------ 933
+LD NDN P F+ + A V E G + +V A D D G NG V Y +
Sbjct: 286 VLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGS 345
Query: 934 ------PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLD 987
F + SGVV LDRE A +QL V A D G + +T ++I VLD
Sbjct: 346 GGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLD 405
Query: 988 VNDETPT----FFPAVYNVSVSEDVPREFRVVWLNCTDND--------------VGL-NA 1028
VND P F VSE V ++ +D D VGL +
Sbjct: 406 VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDG 465
Query: 1029 ELSYFITGGNVDGKFSVGYRDAVVRTVV--GLDRETTAAYMLILEAIDNG--PVGKRHTG 1084
+S + GG D G V V LDRE+ Y L+L A D G P+
Sbjct: 466 SISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEE-- 523
Query: 1085 TATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYR---- 1140
T+ + V D+ND P+F Q Y+ASV E G ++ + A+DADE W R
Sbjct: 524 --TLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVV 581
Query: 1141 --------------ILH-GNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
++H G +F I +G + R LDRE + L V A +
Sbjct: 582 QLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAIST-IRTLDREVQEAVELKVVAQDLGE 640
Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
P+ ++ V + V+D+ND P+F +Q Y+ + E A +G + V A+D DSG G +
Sbjct: 641 PPLSATCLVSITVDDVNDNEPIFWRQVYNAT-IAEHAPVGHCFLQVTASDADSGLYGFIE 699
Query: 1246 YRILSG-----AEGKFEIDESTGLIITVNYLDYE-TKTSYMMNVSATDQAPPFNQGFCSV 1299
Y + G A F ID G I +D E +Y + V A D Q F V
Sbjct: 700 YSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRV 759
Query: 1300 YITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAK 1359
+ +N D F+ ++Y +I + GTEI+ V A D+ T +
Sbjct: 760 DLEDVN--DNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPG-NVS 816
Query: 1360 ALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGP-----KVDSTVKVYITVLDEND- 1413
+LF ID+ TG+I + + + +L V A DGG D T+ ++ T L +
Sbjct: 817 SLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEF 876
Query: 1414 NSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTN 1473
P++ F +PED P+G TVKA +P S+ + + ++SG++ G F I +
Sbjct: 877 ERPKYTFLVYE--DVPEDSPIG----TVKAREP-LNSSEPIFYRISSGDLGGKFSI---H 926
Query: 1474 DSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGY 1533
+G + +PLD E +L V A G+ P + +T++D+NDN P
Sbjct: 927 PRLGTIRTRKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRT-SD 984
Query: 1534 NVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPD 1593
+ +++ GTA+ RA DRD G N ++ Y I + F +DR G + +
Sbjct: 985 EIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGV-FAIDRALGVLFLNGSLGA 1043
Query: 1594 RERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPH--YEVLLDEGPDTLN 1651
E++ L ED+G +A V ++++ +++P + H Y+V + E +
Sbjct: 1044 GEQREL-TLTLRAEDQGVHPQAALL-VLTVVIEKREHSPSWTFEHLVYQVEVSESLSPM- 1100
Query: 1652 TSLITIQALDLDEGPN---GTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
T ++ QA L GP + Y++ F I + G I ++ DYE S Y
Sbjct: 1101 TQMLQTQAHPL--GPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYE-STQTYN 1157
Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPR--VWTF 1766
V A P +TTV+V V D NDN PTF D F E P P+ +
Sbjct: 1158 FRVFA--WIPEDGFLQNVSTTVIVRVWDENDNSPTFLHDV--LFLKVEESPVPQGVIGKI 1213
Query: 1767 LAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1826
A D DSG NGQ+ Y ++ F ++P G L V LDRE + +T+ DR
Sbjct: 1214 TAIDMDSGKNGQLLYFLLSDGKF--FKMNPNTGEL--INWVALDREHRGHHEMTVLVTDR 1269
Query: 1827 GMPPLSSTMLVGIRVLDINDNDP----VLLNLPMNITISENSPVSSFVAHVLASDADSGC 1882
G PP ++TM V + V DINDN P L +++ + E PV+ V V A D D G
Sbjct: 1270 GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGN 1329
Query: 1883 NARLTFNITA 1892
NA +T+++++
Sbjct: 1330 NAEVTYSVSS 1339
Score = 345 bits (884), Expect = 6e-94
Identities = 366/1286 (28%), Positives = 556/1286 (43%), Gaps = 163/1286 (12%)
Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFT 1421
F + TG+I +DRE+ D Y+ G + V+V I V D ND+SPRF
Sbjct: 116 FHVHPDTGIIRTARRLDRERRDHYSFVAATLLG-----AVVQVEIRVNDVNDHSPRFPLD 170
Query: 1422 SDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNI-----AGAF--------- 1467
S + + E P G A DPDAG ++L + AG F
Sbjct: 171 S-LQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPG 229
Query: 1468 ----EIVTTNDSIGE---VFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDI 1520
++ + S E + + R LDREE + LQ+ A D G P R +++ +LD
Sbjct: 230 PLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDE 289
Query: 1521 NDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMA----- 1575
NDNPPV E Y +V E+ G V +VRATDRD+G N + Y + A
Sbjct: 290 NDNPPVFEQD-EYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGG 348
Query: 1576 -------FRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDEN 1628
F ++ +SG + P DRE Q+++ LV D G AT V + ++D N
Sbjct: 349 ALGDAAYFAVEELSGVVRVW-RPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVN 407
Query: 1629 DNAPMFQQPHYEVLLDEGPDTLNTS------LITIQALDLDEG---------------PN 1667
DN P H L + G ++ + + D D +
Sbjct: 408 DNRPAI---HVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGD 464
Query: 1668 GTVTYAIVAGNIVNTFRIDRHMGVITAAKE--LDYEISHGRYTLIVTATDQCPILSHRLT 1725
G+++ ++ G GV E LD E S Y L++ ATD S L+
Sbjct: 465 GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRE-SRDLYELLLVATDAG---SPPLS 520
Query: 1726 STTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPN--------- 1776
+ T+L+ V D+ND P F + + PG V A D D +
Sbjct: 521 TEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTV 580
Query: 1777 ---------GQVEYSIMDGDPLG-EFVISPVEGVLRVRKDVELDRETIAFYNLTICARDR 1826
G ++ ++ G F I G + + LDRE L + A+D
Sbjct: 581 VQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRT--LDREVQEAVELKVVAQDL 638
Query: 1827 GMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL 1886
G PPLS+T LV I V D+NDN+P+ N TI+E++PV V ASDADSG +
Sbjct: 639 GEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFI 698
Query: 1887 TFNITAG----NRERAFFINATTGIVTVNRPLDRERIP-EYKLTISVKDNPENPRIARRD 1941
+++ G +AF I+ G + V++ +DRER P Y L + KD A
Sbjct: 699 EYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQA--- 755
Query: 1942 YDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQ 2001
+ + L D NDNHP+F STY + + + GT ++N +LA D D IY V Y+
Sbjct: 756 --FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGT--EIIN--VLATDQDSGIYGTVAYE 809
Query: 2002 LL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITIL 2060
L+ G S LF I+S+TG++ + + L L++ A+D G L + + +TI
Sbjct: 810 LIPGNVSSLFTIDSTTGIIY----LTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTI- 864
Query: 2061 DDNDNRPTFSPATL-----TVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAG-AQD 2114
+ + T +PA T + E+ P + V A E + + YRI +G
Sbjct: 865 --HIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGG 921
Query: 2115 RFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF 2174
+F IH G IR +D E Q LTV A G+ P + V I + D+ND+ P F
Sbjct: 922 KFSIHPRLGTIRT-RKPLDHETQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAF 979
Query: 2175 LNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFA 2232
L + + ++ PGT + A D D N + Y I Q FA
Sbjct: 980 LRTSDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIAS------------PQPGVFA 1027
Query: 2233 VNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQ 2292
++ G + + + +TL D P+ ++ V LTV V++ +++P
Sbjct: 1028 IDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH-PQAALLV----LTV-VIEKREHSPS 1081
Query: 2293 FKPFGITYYMERILEGATPGTTLIAVAA--VDPDKGLNGLVTYTLLDLVPPGYVQLEDSS 2350
+ + Y +E + E +P T ++ A + P + + L Y+L V + +
Sbjct: 1082 WTFEHLVYQVE-VSESLSPMTQMLQTQAHPLGPQRAASPL-RYSLEPSVDSAMFGIRPYT 1139
Query: 2351 AGKVIANRTVDYEEVHWLNFTVRA--SDNGSPPRAAEIPVYLEIVDINDNNPIF-DQPSY 2407
G + R DYE NF V A ++G + V + + D NDN+P F +
Sbjct: 1140 -GWIYLRRQFDYESTQTYNFRVFAWIPEDGFLQNVS-TTVIVRVWDENDNSPTFLHDVLF 1197
Query: 2408 QEAVFEDVPVGTIILTVTATDADSG-NFALIEYSLGDGESKFAINPTTGDIYVLSSLDRE 2466
+ VP G +I +TA D DSG N L+ + L DG+ F +NP TG++ +LDRE
Sbjct: 1198 LKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLLSDGKF-FKMNPNTGELINWVALDRE 1255
Query: 2467 KKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSK----PQFSTSVYENE 2522
+ H+ +T L D S R ++ V + V D+ND RP F + + V E +
Sbjct: 1256 HRGHHEMTVLVTDR----GSPPRNATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQ 1311
Query: 2523 PAGTSVITMMATDQDEGPNGELTYSL 2548
P V T+ A D DEG N E+TYS+
Sbjct: 1312 PVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 334 bits (856), Expect = 1e-90
Identities = 347/1285 (27%), Positives = 549/1285 (42%), Gaps = 148/1285 (11%)
Query: 1148 NNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPV 1207
++F +H G++ R R LDRER + + + + V+V + V D+ND +P
Sbjct: 114 DDFHVHPDTGII-RTARRLDRERRDHYSFVAATL------LGAVVQVEIRVNDVNDHSPR 166
Query: 1208 FTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAE-------------- 1253
F +L + E + GT+ + A D D+G Y ++ ++
Sbjct: 167 FPLDSL-QLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRY 225
Query: 1254 ------------GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYI 1301
G E L++ + LD E ++ + + A D P G SV +
Sbjct: 226 RTPGPLPSPLLPGSSSPLEPLDLVL-LRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVEL 284
Query: 1302 TLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID-----------NLNQITYRF 1350
+L+E D F Y AA+ E+ G E+ RV+A D Q+
Sbjct: 285 RVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAG 344
Query: 1351 NAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVD-STVKVYITVL 1409
+ + A F ++ ++GV+ V +DRE ++ L V A DGG + + +TV+V I VL
Sbjct: 345 SGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVL 404
Query: 1410 DENDNSPRFD---FTSDSAVSIPEDCPVGQRVATVKA------WDPDAGSNGQVVFSLAS 1460
D NDN P T + E G VA V W+ + + G++ L
Sbjct: 405 DVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGD 464
Query: 1461 GNIAGAFE------IVTTNDSIGEVF--VARPLDREELDHYILQVVASDRGTPPRKKDHI 1512
G+I+ + E + G F V PLDRE D Y L +VA+D G+PP +
Sbjct: 465 GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEET 524
Query: 1513 LQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRD---------------- 1556
L + + D+ND PP+ Y SV+E GT V+ V A+D D
Sbjct: 525 LLLRVADLNDQPPLFSQQH-YKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQL 583
Query: 1557 ---IGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPT 1613
+ S+ S + +F +D SG I+T DRE Q L +D G P
Sbjct: 584 SAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTL-DREVQEAVELKVVAQDLGEPP 642
Query: 1614 LSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYA 1673
LSAT V +T+ D NDN P+F + Y + E + + + A D D G G + Y+
Sbjct: 643 LSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAP-VGHCFLQVTASDADSGLYGFIEYS 701
Query: 1674 IVAGNIV----NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTT 1729
+ G + FRID H G I ++++D E Y L+V A D L++
Sbjct: 702 LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKD-----GGGLSAQAF 756
Query: 1730 VLVNVNDINDNVPTF-PRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDP 1788
V V++ D+NDN P F P Y E QPG + LA D+DSG G V Y ++ G+
Sbjct: 757 VRVDLEDVNDNHPVFNPSTYVTSIS-DETQPGTEIINVLATDQDSGIYGTVAYELIPGNV 815
Query: 1789 LGEFVISPVEGVLRVRKDVE-LDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDN 1847
F I G++ + + L+ T++ L + A+D G V I +
Sbjct: 816 SSLFTIDSTTGIIYLTLPLSHLESTTLS---LMVSAQDGGGLTAVINADVTIHIFQTTLA 872
Query: 1848 DPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGI 1907
+ E+ P S + V A + + + + I++G+ F I+ G
Sbjct: 873 PAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEP-IFYRISSGDLGGKFSIHPRLGT 931
Query: 1908 VTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAE 1967
+ +PLD E P LT+ + P + + ++ ++ D NDNHP F +++ +
Sbjct: 932 IRTRKPLDHETQPVVVLTVQAQLGSA-PACSSTEVNITVM---DVNDNHPAFLRTSDEIR 987
Query: 1968 VMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII 2027
+ + +P GT L + A D D ++ Y + Q G+F I+ + GV+ + +
Sbjct: 988 ISQTTPPGTALYLAR----AEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSL-- 1041
Query: 2028 DREAFSPPILELLLLAEDIGLLNSTAHLLITI-LDDNDNRP--TFSPATLTVHLLENCPP 2084
A L L L AED G+ A L++T+ ++ ++ P TF V + E+ P
Sbjct: 1042 --GAGEQRELTLTLRAEDQGVHPQAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSP 1099
Query: 2085 GFSVLQVTATD-EDSGLNGELVYRIEAGAQDR-FLIHLVTGVIRVGNATIDREEQESYRL 2142
+LQ A L Y +E F I TG I + D E ++Y
Sbjct: 1100 MTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYL-RRQFDYESTQTYNF 1158
Query: 2143 TVVA---TDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAI 2199
V A D +S T IV + D ND+ P FL+ + + V ES P VI ITAI
Sbjct: 1159 RVFAWIPEDGFLQNVSTTVIVRVW--DENDNSPTFLHDVLFLKVEESPVPQGVIGKITAI 1216
Query: 2200 DHDL--NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVT 2257
D D N +L Y ++ + F +N NTG ++ ++RE +E+T
Sbjct: 1217 DMDSGKNGQLLYFLL-------------SDGKFFKMNPNTGELINWVALDREHRGHHEMT 1263
Query: 2258 LSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPF--GITYYMERILEGATPGTTL 2315
+ V D S P R+ ++ + V+V D+NDN P F G ++ ++LEG +
Sbjct: 1264 VLVTDRGS--PPRNATMA---VYVSVTDINDNRPFFPQCLPGKELHV-KVLEGQPVNMLV 1317
Query: 2316 IAVAAVDPDKGLNGLVTYTLLDLVP 2340
V A DPD+G N VTY++ P
Sbjct: 1318 TTVFAKDPDEGNNAEVTYSVSSARP 1342
Score = 325 bits (833), Expect = 5e-88
Identities = 365/1341 (27%), Positives = 550/1341 (41%), Gaps = 174/1341 (12%)
Query: 1643 LDEG--PDTLNTSLIT-IQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELD 1699
+DEG PDTL + + A EG ++ +++ F + G+I A+ LD
Sbjct: 73 VDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRLD 132
Query: 1700 YEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE-GQ 1758
E Y+ + L + V + VND+ND+ P FP D +V+E
Sbjct: 133 RE-RRDHYSFVAATL---------LGAVVQVEIRVNDVNDHSPRFPLD-SLQLDVSELSP 181
Query: 1759 PGPRVWTFLAHDRDSGPNGQVEYSIMDG-----DPLGEFV-------------------- 1793
PG +AHD D+G Y+++ DP G F
Sbjct: 182 PGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSS 241
Query: 1794 -ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLL 1852
+ P++ VL R LDRE A + L I A D G P + + V +RVLD NDN PV
Sbjct: 242 PLEPLDLVLLRR----LDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDENDNPPVFE 297
Query: 1853 NLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERA------------FF 1900
+ E++ + V V A+D D G N + +++ A A F
Sbjct: 298 QDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFA 357
Query: 1901 INATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHP--- 1957
+ +G+V V RPLDRE ++L + +D P +A + ++ D NDN P
Sbjct: 358 VEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVL---DVNDNRPAIH 414
Query: 1958 -LFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL---LGAQSGLFDIN 2013
LF A V E + G + ++ + D D + T +L LG S +
Sbjct: 415 VLFLTEGGVARVSEGARPGDYVARVS--VSDADGDWEKEDEATGELGVGLGDGSISLSLE 472
Query: 2014 SSTGVVTVRSGVI-----------IDREAFSPPILELLLLAEDIGL--LNSTAHLLITIL 2060
G + G +DRE S + ELLL+A D G L++ LL+ +
Sbjct: 473 GGEGDFALLPGGPPGVFFLCVEGPLDRE--SRDLYELLLVATDAGSPPLSTEETLLLRVA 530
Query: 2061 DDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSG--------------------- 2099
D ND P FS + E PG V+ V+A+D D
Sbjct: 531 DLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLG 590
Query: 2100 -LNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTA 2158
L ++V+ E G F I +G I T+DRE QE+ L VVA D G PLS T
Sbjct: 591 SLQSKMVHTAECGPS--FAIDSESGAISTIR-TLDREVQEAVELKVVAQDLGEPPLSATC 647
Query: 2159 IVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKD 2218
+V+I +DD+ND+ P F + ++ E A G +TA D D + G +
Sbjct: 648 LVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSG------LYGFIEYS 701
Query: 2219 DTDRLVPNQE-DAFAVNINTGSVMVKSPMNREL-VATYEVTLSVIDNASDLPERSVSVPN 2276
D + + AF ++ + G + V ++RE ATY++ + D +
Sbjct: 702 LYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQ------- 754
Query: 2277 AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL 2336
A + V++ DVNDN P F P + Y+ I + PGT +I V A D D G+ G V Y L+
Sbjct: 755 AFVRVDLEDVNDNHPVFNP---STYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELI 811
Query: 2337 DLVPPGYVQ---LEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
PG V DS+ G + + + E L+ V A D G V + I
Sbjct: 812 ----PGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF 867
Query: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDA-DSGNFALIEYSLGDGESKFAINP 2452
F++P Y V+EDVP + I TV A + +S S GD KF+I+P
Sbjct: 868 QTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHP 927
Query: 2453 TTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKP 2512
G I LD E + +LT A+ S S +V I V+DVND P F +
Sbjct: 928 RLGTIRTRKPLDHETQPVVVLTVQAQLGSAPACS-----STEVNITVMDVNDNHPAFLRT 982
Query: 2513 QFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ 2572
+ + P GT++ A D+D G NG + YS+ P F +D G++ L
Sbjct: 983 SDEIRISQTTPPGTALYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLG 1042
Query: 2573 SYE--KFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRS 2630
+ E + +LT+ A D G P ++L VI+ ++ P + + + E + +
Sbjct: 1043 AGEQRELTLTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMT 1101
Query: 2631 NVYEVYATD-KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSL 2689
+ + A + +RYS + D F I P +G I ++ D ES Y+
Sbjct: 1102 QMLQTQAHPLGPQRAASPLRYSLEPSV---DSAMFGIRPYTGWIYLRRQFDYESTQTYNF 1158
Query: 2690 ILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGN 2749
+ A + V + D +DN P F+ L V E ++G
Sbjct: 1159 RVFAWIPEDGFLQNVSTTVIVRVWDENDNSPTFLH------DVLFLKVEESPVPQGVIGK 1212
Query: 2750 VTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSN 2808
+T A+D D G N + YF+ ++ K F + P+ G L+ LDRE V +
Sbjct: 1213 IT-AIDMDSGKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDR 1269
Query: 2809 RSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKA----EYTAGVATDAKVGSE 2864
S PPR + V V + DIND P F + E V V
Sbjct: 1270 GS--PPRNAT-----------MAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNML 1316
Query: 2865 LIQVLALDADIGNNSLVFYSI 2885
+ V A D D GNN+ V YS+
Sbjct: 1317 VTTVFAKDPDEGNNAEVTYSV 1337
Score = 323 bits (827), Expect = 2e-87
Identities = 359/1281 (28%), Positives = 544/1281 (42%), Gaps = 153/1281 (11%)
Query: 824 YSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDL 883
+ ++ TG IRT LDRE D + V+ T G + V + + D+
Sbjct: 116 FHVHPDTGIIRTARR-LDRERRDHYS-------FVAATLLG-------AVVQVEIRVNDV 160
Query: 884 NDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM--PVGMPR------ 935
ND+ P F +V E P G + VA D D GL Y + P +P+
Sbjct: 161 NDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPF 220
Query: 936 ------------MDFLINSSSGV----VVTTTELDRERIAEYQLRVVASDAGTPTKSSTS 979
L SSS + +V LDRE A ++L++ A D G P ++
Sbjct: 221 FQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLL 280
Query: 980 TLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNV 1039
++ + VLD ND P F Y +V ED V + TD D+G N + Y + V
Sbjct: 281 SVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQV 340
Query: 1040 DGK------------FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTAT 1087
G F+V VVR LDRE A + L++EA D G + T
Sbjct: 341 PGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGG--AEPEVATVR 398
Query: 1088 VFVTVLDVNDNRP----IFLQSSYEASVPEDIPEGHSILQLKATDAD---------EGEF 1134
V + VLDVNDNRP +FL A V E G + ++ +DAD GE
Sbjct: 399 VSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGEL 458
Query: 1135 GRVWYRILHGNHGNNFRIHVSNG---LLMRGP---------RPLDRERNSSHVLIVEAYN 1182
G + G+ + + G LL GP PLDRE + L++ A +
Sbjct: 459 G-----VGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATD 513
Query: 1183 HDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRD--SGD 1240
P+ + +++ V D+ND+ P+F+QQ Y + + E A GT V+ V A+D D D
Sbjct: 514 AGSPPLSTEETLLLRVADLNDQPPLFSQQHY-KASVSEAAAPGTVVMWVSASDADEAGSD 572
Query: 1241 GGLVNYRI--------LSGAEGK----------FEIDESTGLIITVNYLDYETKTSYMMN 1282
+ Y + L + K F ID +G I T+ LD E + + +
Sbjct: 573 HAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELK 632
Query: 1283 VSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN 1342
V A D P C V IT+ + D F Y A I E+ +G ++V A D+
Sbjct: 633 VVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADS 692
Query: 1343 --LNQITYR-FNAYTSTQAKALFKIDAITGVITVQGLVDREKGD-FYTLTVVADDGGPKV 1398
I Y ++ + S +A F+ID G I V +DRE+ Y L V A DGG +
Sbjct: 693 GLYGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGG-GL 751
Query: 1399 DSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSL 1458
+ V + + D NDN P F+ S SI ++ G + V A D D+G G V + L
Sbjct: 752 SAQAFVRVDLEDVNDNHPVFN-PSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYEL 810
Query: 1459 ASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRG--TPPRKKD---HIL 1513
GN++ F I +T G +++ PL E L V A D G T D HI
Sbjct: 811 IPGNVSSLFTIDSTT---GIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIF 867
Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
Q T+ P E P Y V E+V + + V+A + + + + Y I+ G+
Sbjct: 868 QTTLA-----PAEFERP-KYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLG 920
Query: 1574 MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDE-GTPTLSATTHVYVTIVDENDNAP 1632
F + G I TR P D E Q +V TV+ + G+ ++T V +T++D NDN P
Sbjct: 921 GKFSIHPRLGTIRTR-KPLDHETQPV--VVLTVQAQLGSAPACSSTEVNITVMDVNDNHP 977
Query: 1633 MFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVI 1692
F + E+ + + T+L +A D D G NG + Y+I A F IDR +GV+
Sbjct: 978 AFLRTSDEIRISQTTPP-GTALYLARAEDRDSGRNGLIRYSI-ASPQPGVFAIDRALGVL 1035
Query: 1693 TAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDY-EGP 1751
L TL + A DQ + VL V + ++ P++ ++
Sbjct: 1036 FLNGSLGAG-EQRELTLTLRAEDQ----GVHPQAALLVLTVVIEKREHSPSWTFEHLVYQ 1090
Query: 1752 FEVTEGQPGPRVWTFLAHDRDSGPN---GQVEYSIMDGDPLGEFVISPVEGVLRVRKDVE 1808
EV+E P GP + YS+ F I P G + +R+ +
Sbjct: 1091 VEVSESL-SPMTQMLQTQAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRR--Q 1147
Query: 1809 LDRETIAFYNLTICA---RDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSP 1865
D E+ YN + A D + +S+T++V RV D NDN P L+ + + + E+
Sbjct: 1148 FDYESTQTYNFRVFAWIPEDGFLQNVSTTVIV--RVWDENDNSPTFLHDVLFLKVEESPV 1205
Query: 1866 VSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLT 1925
+ + A D DSG N +L + + + + F +N TG + LDRE +++T
Sbjct: 1206 PQGVIGKITAIDMDSGKNGQLLYFLLSDG--KFFKMNPNTGELINWVALDREHRGHHEMT 1263
Query: 1926 ISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPI 1985
+ V D PR A + + ++D NDN P F + E+ G P+ +L +
Sbjct: 1264 VLVTDRGSPPRNATM---AVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTV 1320
Query: 1986 LALDADQDIYAVVTYQLLGAQ 2006
A D D+ A VTY + A+
Sbjct: 1321 FAKDPDEGNNAEVTYSVSSAR 1341
Score = 318 bits (815), Expect = 6e-86
Identities = 356/1318 (27%), Positives = 561/1318 (42%), Gaps = 151/1318 (11%)
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYI----SGVLTLNGLL 299
++ E PP T V I A + G G+ + + +S D+ +G++ L
Sbjct: 72 SVDEGLPPDTLVGDIRAGLPAAQQQEGSGFFLSEDSDDSPLLDDFHVHPDTGIIRTARRL 131
Query: 300 DRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
DRE + T+ G + + I V D+ND++P F + ++E
Sbjct: 132 DRERRDHYSFVAATLLGAVVQVE-------------IRVNDVNDHSPRFPLDSLQLDVSE 178
Query: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKA-DIRIRVA-- 416
L+ G A L V D + GL S LV + P G +R R
Sbjct: 179 LSPPGTAFRL---PVAHDPDAGLFSTQGYTLVQPSD-----LPKDPAGPFFQLRYRTPGP 230
Query: 417 -------------IPLDYETVDRYDFDLFANESV---------PDHVGYAKVKITLINEN 454
PLD + R D + A + P G V++ +++EN
Sbjct: 231 LPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDEN 290
Query: 455 DNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFS-------------- 500
DN P+F Q Y ++ E+ G V V ATD D G G V Y
Sbjct: 291 DNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL 350
Query: 501 DDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEE--TTGRVRINVLDVNDNV 558
D F++++ +G++ + LD E L + ARDGG E T RV I VLDVNDN
Sbjct: 351 GDAAYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNR 410
Query: 559 PT----FQKDAYVGALRENEPSVTQLVRLRATDEDSP--PNNQITYSI--------VSAS 604
P F + V + E + R+ +D D ++ T + +S S
Sbjct: 411 PAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLS 470
Query: 605 AFGSYFDISLYEGY--GV--ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
G D +L G GV + V PLD E S L L ++A DAG+PPL++ + +
Sbjct: 471 LEGGEGDFALLPGGPPGVFFLCVEGPLDRE--SRDLYELLLVATDAGSPPLSTEETLLLR 528
Query: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYG--------------- 705
V D ND PP FS+ Y SV E G V++++A+D D +
Sbjct: 529 VADLNDQPPLFSQQHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCN 588
Query: 706 ----QESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGI 761
Q ++++ E F I++ SG I+T LDRE + L V A D +G +
Sbjct: 589 LGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQD--LGEPPLSAT 646
Query: 762 ATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSI---- 817
V+IT+ D+NDN P + Y + E P V A D D G G + YS+
Sbjct: 647 CLVSITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGF 706
Query: 818 ---QPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
+ P F ++ G+I + +DRE DP +L+ V D G ++ A
Sbjct: 707 LSYEAPQAF-RIDPHDGQICVSQD-IDRER-DPATYDLL----VEAKDGGG----LSAQA 755
Query: 875 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMP 934
V V+L D+NDN P F +V + + G I V+A D D G+ G V+Y + G
Sbjct: 756 FVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV 815
Query: 935 RMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPT 994
F I+S++G++ T L L V A D G T + +TIH+
Sbjct: 816 SSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAE 875
Query: 995 FFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRT 1054
F Y V EDVP + + + + + + + Y I+ G++ GKFS+ R +RT
Sbjct: 876 FERPKYTFLVYEDVPEDSPIGTVKARE-PLNSSEPIFYRISSGDLGGKFSIHPRLGTIRT 934
Query: 1055 VVGLDRETTAAYMLILEA-IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPE 1113
LD ET +L ++A + + P + V +TV+DVNDN P FL++S E + +
Sbjct: 935 RKPLDHETQPVVVLTVQAQLGSAPA----CSSTEVNITVMDVNDNHPAFLRTSDEIRISQ 990
Query: 1114 DIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLL-MRGPRPLDRERNS 1172
P G ++ +A D D G G + Y I G F I + G+L + G +R
Sbjct: 991 TTPPGTALYLARAEDRDSGRNGLIRYSIASPQPG-VFAIDRALGVLFLNGSLGAGEQREL 1049
Query: 1173 SHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFT-QQQYSRLGLRETAGIGTSVIVV 1231
+ L + A + + P ++++ V+ V + + +P +T + ++ + E+ T ++
Sbjct: 1050 T--LTLRAEDQGVHP-QAALLVLTVVIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQT 1106
Query: 1232 QATD-RDSGDGGLVNYRILSGAE-GKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQA 1289
QA + Y + + F I TG I DYE+ +Y V A
Sbjct: 1107 QAHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPE 1166
Query: 1290 PPFNQGF-CSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN--LNQI 1346
F Q +V + + +E D + F + + E+ I ++ A +D+ Q+
Sbjct: 1167 DGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQL 1226
Query: 1347 TYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTV-VADDGGPKVDSTVKVY 1405
Y + + K FK++ TG + +DRE + +TV V D G P ++T+ VY
Sbjct: 1227 LY----FLLSDGK-FFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATMAVY 1281
Query: 1406 ITVLDENDNSPRFDFT---SDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLAS 1460
++V D NDN P F + V + E PV V TV A DPD G+N +V +S++S
Sbjct: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 292 bits (747), Expect = 4e-78
Identities = 300/1136 (26%), Positives = 467/1136 (41%), Gaps = 131/1136 (11%)
Query: 89 LRQPLDRETKSEFTVEFSVSD-----HQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPE 143
L + LDRE + ++ D G+++ V ++V D NDN P F Y + E
Sbjct: 250 LLRRLDREEAAAHRLQIEAWDGGRPRRTGLLS--VELRVLDENDNPPVFEQDEYRAAVRE 307
Query: 144 NTPVGTPIFIVNATDPDLGAGGSVLYSFQP--------------PSQFFAIDSARGIVTV 189
+ G + V ATD DLG G V YS + + +FA++ G+V V
Sbjct: 308 DAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRV 367
Query: 190 IRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP----IFINLPYSTNI 245
R LD E +QL V A D ++T+ ++I + DV D P +F+ +
Sbjct: 368 WRPLDREAQAWHQLVVEARDGGAEPEVATV-RVSIAVLDVNDNRPAIHVLFLTEGGVARV 426
Query: 246 YEHSPPGTTVRIITAIDQDKGRPR--------GIG----------------YTIVSGNTN 281
E + PG V ++ D D + G+G + ++ G
Sbjct: 427 SEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPP 486
Query: 282 SIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVID 340
+F L + G LDRE+ LY + T G+ + T + V D
Sbjct: 487 GVF-------FLCVEGPLDRESRDLYELLLVATDAGS--------PPLSTEETLLLRVAD 531
Query: 341 INDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNS----- 395
+ND P F+ Y +++E A G + +++ D DE G + + Y V S
Sbjct: 532 LNDQPPLFSQQHYKASVSEAAAPG-TVVMWVSASDADE-AGSDHAWLRYTVVQLSAPCNL 589
Query: 396 --------HHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGYAKV 446
H P+ I LD E + + + A + P V
Sbjct: 590 GSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEPPLSATCLV 649
Query: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD---- 502
IT+ + NDN PIF + +YN ++ E+ VG L V A+D D+G +G + Y D
Sbjct: 650 SITVDDVNDNEPIFWRQVYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYDGFLSY 709
Query: 503 --PDRFSLDKDTGLIMLIARLDYEL-IQRFTLTIIARDGGGEETTGRVRINVLDVNDNVP 559
P F +D G I + +D E + L + A+DGGG VR+++ DVNDN P
Sbjct: 710 EAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLEDVNDNHP 769
Query: 560 TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
F YV ++ + T+++ + ATD+DS + Y ++ + S F I G
Sbjct: 770 VFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNV-SSLFTID--STTG 826
Query: 620 VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVS 679
+I ++ PL + + + + L V A D G VTI +F P F +P Y
Sbjct: 827 IIYLTLPLSH--LESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL 884
Query: 680 VVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGST---QFRINARSGEITTTSLLDR 736
V E++ + + + A R E I Y + +F I+ R G I T LD
Sbjct: 885 VYEDVPEDSPIGTVKA----REPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDH 940
Query: 737 ETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSD 796
ET+ +L V+A G T VNIT++D+NDNHP + I + + TPP +
Sbjct: 941 ETQPVVVLTVQAQLGSAPACSST---EVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTA 997
Query: 797 VTTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRK 855
+ A D D G NG + YSI P ++++ G + L+ + EL
Sbjct: 998 LYLARAEDRDSGRNGLIRYSIASPQPGVFAIDRALGVL-----FLNGSLGAGEQREL--T 1050
Query: 856 IVVSVTDCGRPPLKATSSATVFVNLLDLNDNDP--TFQNLPFVAEVLEGIPAGVSIYQVV 913
+ + D G P A TV +++ ++ P TF++L + EV E + + Q
Sbjct: 1051 LTLRAEDQGVHPQAALLVLTV---VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQ 1107
Query: 914 AIDL-DEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA--SDA 970
A L + + Y + + F I +G + + D E Y RV A +
Sbjct: 1108 AHPLGPQRAASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED 1167
Query: 971 GTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAEL 1030
G ST T+ + V D ND +PTF V + V E + + + D D G N +L
Sbjct: 1168 GFLQNVST-TVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQL 1226
Query: 1031 SYFITGGNVDGK-FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVF 1089
YF+ DGK F + + V LDRE + + + D G T V+
Sbjct: 1227 LYFLLS---DGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRG--SPPRNATMAVY 1281
Query: 1090 VTVLDVNDNRPIFLQ----SSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRI 1141
V+V D+NDNRP F Q V E P + + A D DEG V Y +
Sbjct: 1282 VSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Score = 284 bits (726), Expect = 1e-75
Identities = 346/1296 (26%), Positives = 552/1296 (42%), Gaps = 160/1296 (12%)
Query: 56 LAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVIT 115
L++D D+ PL+ F V PDTG++ + LDRE + ++ F + G +
Sbjct: 103 LSEDSDDSPLLDD---------FHVHPDTGIIRTARRLDRERRDHYS--FVAATLLGAVV 151
Query: 116 RKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPS 175
+ V I+V DVND++P F + + E +P GT + A DPD G + Y+ PS
Sbjct: 152 Q-VEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPS 210
Query: 176 Q--------FFAI--------------DSARGI----VTVIRELDYETTQAYQLTVNATD 209
FF + S+ + + ++R LD E A++L + A D
Sbjct: 211 DLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWD 270
Query: 210 QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPR 269
+ R + L ++ + + D D P+F Y + E + PG V + A D+D G
Sbjct: 271 GGRPR-RTGLLSVELRVLDENDNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNG 329
Query: 270 GIGYTI----VSG--------NTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGT 317
+ Y++ V G + FA++ +SGV+ + LDRE + H ++ +
Sbjct: 330 FVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRPLDREAQAW-HQLVVEAR-- 386
Query: 318 ELNDDRTPSDATVTTTFNILVIDINDNAPEFN---SSEYSVA-ITELAQVG-FALPLFIQ 372
D T +I V+D+NDN P + +E VA ++E A+ G + + +
Sbjct: 387 ----DGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVS 442
Query: 373 VVDKDENLGLNSMFEVYL-VGNNSHHFIISPTSVQGKADIRIR-----------VAIPLD 420
D D + E+ + +G+ S IS + G+ D + V PLD
Sbjct: 443 DADGDWEKEDEATGELGVGLGDGS----ISLSLEGGEGDFALLPGGPPGVFFLCVEGPLD 498
Query: 421 YETVDRYDFDLFANESVPDHVGYAKVKITLINE-NDNRPIFSQPLYNISLYENVTVGTSV 479
E+ D Y+ L A ++ + + + + + ND P+FSQ Y S+ E GT V
Sbjct: 499 RESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAPGTVV 558
Query: 480 LTVLATDND---------------------AGTFGEVSYFFSDDPDRFSLDKDTGLIMLI 518
+ V A+D D G+ ++ F++D ++G I I
Sbjct: 559 MWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTI 618
Query: 519 ARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPS 576
LD E+ + L ++A+D G T V I V DVNDN P F + Y + E+ P
Sbjct: 619 RTLDREVQEAVELKVVAQDLGEPPLSATCLVSITVDDVNDNEPIFWRQVYNATIAEHAPV 678
Query: 577 VTQLVRLRATDEDSPPNNQITYSIVSASAFGSY-----FDISLYEGYGVISVSRPLDYEQ 631
+++ A+D DS I YS+ F SY F I ++G I VS+ +D E+
Sbjct: 679 GHCFLQVTASDADSGLYGFIEYSLY--DGFLSYEAPQAFRIDPHDGQ--ICVSQDIDRER 734
Query: 632 ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVL 691
L V A D G L++ V +++ D NDN P F+ Y S+ + G ++
Sbjct: 735 -DPATYDLLVEAKDGGG--LSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEII 791
Query: 692 FLNATDLDRSREYGQESIIYSL---EGSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748
+ ATD D S YG ++ Y L S+ F I++ +G I T L + L+V A
Sbjct: 792 NVLATDQD-SGIYG--TVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLESTTLSLMVSA 848
Query: 749 VDGGVGHNQKTGIATVNITLLDINDN-HPTWKDAPYYINLV-EMTPPDSDVTTVVAVDPD 806
DGG T + ++T+ P + P Y LV E P DS + TV A +P
Sbjct: 849 QDGG----GLTAVINADVTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIGTVKAREP- 903
Query: 807 LGENGTLVYSIQPPN--KFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCG 864
L + + Y I + +S++ G IRT P HE + +VV
Sbjct: 904 LNSSEPIFYRISSGDLGGKFSIHPRLGTIRT-------RKPLDHETQ---PVVVLTVQAQ 953
Query: 865 RPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGL 924
A SS V + ++D+NDN P F + + P G ++Y A D D G NGL
Sbjct: 954 LGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARAEDRDSGRNGL 1013
Query: 925 VSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIH 984
+ Y + P + F I+ + GV+ L E L + A D G +++ LT+
Sbjct: 1014 IRYSIASPQPGV-FAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVHPQAALLVLTV- 1071
Query: 985 VLDVNDETP--TFFPAVYNVSVSEDVPREFRVVWLNCTDNDVG---LNAELSYFITGGNV 1039
V++ + +P TF VY V VSE + ++ L + +G + L Y +
Sbjct: 1072 VIEKREHSPSWTFEHLVYQVEVSESLSPMTQM--LQTQAHPLGPQRAASPLRYSLEPSVD 1129
Query: 1040 DGKFSVGYRDAVVRTVVGLDRETTAAY-MLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
F + + D E+T Y + I G + TV V V D NDN
Sbjct: 1130 SAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWIPED--GFLQNVSTTVIVRVWDENDN 1187
Query: 1099 RPIFLQSSYEASVPED-IPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNG 1157
P FL V E +P+G I ++ A D D G+ G++ Y +L + G F+++ + G
Sbjct: 1188 SPTFLHDVLFLKVEESPVPQG-VIGKITAIDMDSGKNGQLLYFLL--SDGKFFKMNPNTG 1244
Query: 1158 LLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQ---QQYS 1214
L+ LDRE H + V + P +++ V V V DIND P F Q +
Sbjct: 1245 ELINWV-ALDREHRGHHEMTVLVTDRGSPPRNATMAVYVSVTDINDNRPFFPQCLPGKEL 1303
Query: 1215 RLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILS 1250
+ + E + V V A D D G+ V Y + S
Sbjct: 1304 HVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSVSS 1339
Score = 272 bits (696), Expect = 4e-72
Identities = 298/1103 (27%), Positives = 474/1103 (42%), Gaps = 137/1103 (12%)
Query: 42 ISEDTPVGSSVTQLLAQDMDNDPLVF-----------------GVSGEEASRFFAVEPDT 84
+ ED G+ V ++ A D D P F G G+ A +FAVE +
Sbjct: 305 VREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAA--YFAVEELS 362
Query: 85 GVVWLRQPLDRETKSEFTVEFSVSD---HQGVITRKVNIQVGDVNDNAPTFH----NQPY 137
GVV + +PLDRE ++ + D V T +V+I V DVNDN P H +
Sbjct: 363 GVVRVWRPLDREAQAWHQLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGG 422
Query: 138 SVRIPENTPVGTPIFIVNATDPD------------LGAG---GSVLYSFQPPSQFFAI-- 180
R+ E G + V+ +D D LG G GS+ S + FA+
Sbjct: 423 VARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLP 482
Query: 181 DSARGIVTVIRE--LDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFIN 238
G+ + E LD E+ Y+L + ATD + PLST L + + D+ D P+F
Sbjct: 483 GGPPGVFFLCVEGPLDRESRDLYELLLVATDAG-SPPLSTEETLLLRVADLNDQPPLFSQ 541
Query: 239 LPYSTNIYEHSPPGTTVRIITAIDQDKGRP--RGIGYTIV-----------------SGN 279
Y ++ E + PGT V ++A D D+ + YT+V +
Sbjct: 542 QHYKASVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAE 601
Query: 280 TNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVI 339
FA+D SG ++ LDRE L V +L + + T +I V
Sbjct: 602 CGPSFAIDSESGAISTIRTLDRE---VQEAVELKVVAQDLGE----PPLSATCLVSITVD 654
Query: 340 DINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL-----NSMFEVYLVGNN 394
D+NDN P F Y+ I E A VG F+QV D + GL S+++ +L
Sbjct: 655 DVNDNEPIFWRQVYNATIAEHAPVGHC---FLQVTASDADSGLYGFIEYSLYDGFLSYEA 711
Query: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHV-GYAKVKITLINE 453
F I P D +I V+ +D E D +DL + A V++ L +
Sbjct: 712 PQAFRIDP------HDGQICVSQDIDRER-DPATYDLLVEAKDGGGLSAQAFVRVDLEDV 764
Query: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFF--SDDPDRFSLDKD 511
NDN P+F+ Y S+ + GT ++ VLATD D+G +G V+Y + F++D
Sbjct: 765 NDNHPVFNPSTYVTSISDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDST 824
Query: 512 TGLIMLIARLDYELIQRFTLTIIARDGGG--EETTGRVRINVLDVNDNVPTFQKDAYVGA 569
TG+I L L + +L + A+DGGG V I++ F++ Y
Sbjct: 825 TGIIYLTLPLSHLESTTLSLMVSAQDGGGLTAVINADVTIHIFQTTLAPAEFERPKYTFL 884
Query: 570 LRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDY 629
+ E+ P + + ++A E + I Y I S G + S++ G I +PLD+
Sbjct: 885 VYEDVPEDSPIGTVKAR-EPLNSSEPIFYRISSGDLGGKF---SIHPRLGTIRTRKPLDH 940
Query: 630 EQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT 689
E + ++ LTV A G+ P S+ V I V D NDN P F + + + + + G
Sbjct: 941 E--TQPVVVLTVQA-QLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTA 997
Query: 690 VLFLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIV 746
+ A D R+ G+ +I S Q F I+ G + L + E L +
Sbjct: 998 LYLARAED----RDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTL 1053
Query: 747 RAVDGGVGHNQKTGIATVNITLLDINDNHPTW--KDAPYYINLVEMTPPDSDV--TTVVA 802
RA D GV + TV +++ ++ P+W + Y + + E P + + T
Sbjct: 1054 RAEDQGVHPQAALLVLTV---VIEKREHSPSWTFEHLVYQVEVSESLSPMTQMLQTQAHP 1110
Query: 803 VDPDLGENGTLVYSIQP--PNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSV 860
+ P + L YS++P + + + TG I D E+ + ++ +
Sbjct: 1111 LGPQRAAS-PLRYSLEPSVDSAMFGIRPYTGWI-YLRRQFDYESTQTYNF----RVFAWI 1164
Query: 861 TDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEG-IPAGVSIYQVVAIDLDE 919
+ G S TV V + D NDN PTF + +V E +P GV I ++ AID+D
Sbjct: 1165 PEDG---FLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEESPVPQGV-IGKITAIDMDS 1220
Query: 920 GLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTS 979
G NG + Y + F +N ++G ++ LDRE +++ V+ +D G+P +++T
Sbjct: 1221 GKNGQLLYFLL--SDGKFFKMNPNTGELINWVALDREHRGHHEMTVLVTDRGSPPRNATM 1278
Query: 980 TLTIHVLDVNDETPTFFPAV-----YNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1034
+ + V D+ND P FFP +V V E P V + D D G NAE++Y +
Sbjct: 1279 AVYVSVTDINDNRP-FFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTYSV 1337
Query: 1035 TGGN---VDGKFSVGYRDAVVRT 1054
+ + GK + G + +T
Sbjct: 1338 SSARPMPLKGKTAFGKQSCKKQT 1360
Score = 261 bits (666), Expect = 1e-68
Identities = 316/1219 (25%), Positives = 504/1219 (41%), Gaps = 150/1219 (12%)
Query: 1766 FLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARD 1825
FL+ D D P L +F + P G++R + LDRE Y+
Sbjct: 102 FLSEDSDDSPL------------LDDFHVHPDTGIIRTAR--RLDRERRDHYSFVAATL- 146
Query: 1826 RGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNAR 1885
L + + V IRV D+ND+ P + + +SE SP + +A D D+G +
Sbjct: 147 -----LGAVVQVEIRVNDVNDHSPRFPLDSLQLDVSELSPPGTAFRLPVAHDPDAGLFST 201
Query: 1886 LTFNI--------------------TAGNRERAFFINATTGIVTVN----RPLDRERIPE 1921
+ + T G +++ + ++ R LDRE
Sbjct: 202 QGYTLVQPSDLPKDPAGPFFQLRYRTPGPLPSPLLPGSSSPLEPLDLVLLRRLDREEAAA 261
Query: 1922 YKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVL 1981
++L I D R +L ++ DENDN P+F + Y+A V E++ G + +
Sbjct: 262 HRLQIEAWDGGRPRRTGLLSVELRVL---DENDNPPVFEQDEYRAAVREDAQPGAEVCRV 318
Query: 1982 NGPILALDADQDI-YAVVTYQLLGAQSG--------LFDINSSTGVVTVRSGVIIDREAF 2032
L + + Y+V Q+ GA SG F + +GVV V +DREA
Sbjct: 319 RATDRDLGPNGFVRYSVRARQVPGAGSGGGALGDAAYFAVEELSGVVRVWRP--LDREAQ 376
Query: 2033 SPPILELLLLAEDIGLLN--STAHLLITILDDNDNRPTFSPATLT----VHLLENCPPGF 2086
+ +L++ A D G +T + I +LD NDNRP LT + E PG
Sbjct: 377 AWH--QLVVEARDGGAEPEVATVRVSIAVLDVNDNRPAIHVLFLTEGGVARVSEGARPGD 434
Query: 2087 SVLQVTATDEDS--------------GL-NGELVYRIEAGAQDRFLIHL-VTGVIRVG-N 2129
V +V+ +D D GL +G + +E G D L+ GV +
Sbjct: 435 YVARVSVSDADGDWEKEDEATGELGVGLGDGSISLSLEGGEGDFALLPGGPPGVFFLCVE 494
Query: 2130 ATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEP 2189
+DRE ++ Y L +VATD G+ PLS + + + D+ND P F SV E+A P
Sbjct: 495 GPLDRESRDLYELLLVATDAGSPPLSTEETLLLRVADLNDQPPLFSQQHYKASVSEAAAP 554
Query: 2190 GTVIANITAIDHDL----NPKLEYHIVGIVAKDDT----DRLVPNQE--DAFAVNINTGS 2239
GTV+ ++A D D + L Y +V + A + ++V E +FA++ +G+
Sbjct: 555 GTVVMWVSASDADEAGSDHAWLRYTVVQLSAPCNLGSLQSKMVHTAECGPSFAIDSESGA 614
Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
+ ++RE+ E L V+ A DL E +S +++ V DVNDN P F
Sbjct: 615 ISTIRTLDREVQEAVE--LKVV--AQDLGEPPLSA-TCLVSITVDDVNDNEPIFWR---Q 666
Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE-------DSSAG 2352
Y I E A G + V A D D GL G + Y+L D G++ E D G
Sbjct: 667 VYNATIAEHAPVGHCFLQVTASDADSGLYGFIEYSLYD----GFLSYEAPQAFRIDPHDG 722
Query: 2353 KVIANRTVDYE-EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAV 2411
++ ++ +D E + + V A D G A + V LE D+NDN+P+F+ +Y ++
Sbjct: 723 QICVSQDIDRERDPATYDLLVEAKDGGGLSAQAFVRVDLE--DVNDNHPVFNPSTYVTSI 780
Query: 2412 FEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKD 2469
++ GT I+ V ATD DSG + + Y L G+ S F I+ TTG IY+ L +
Sbjct: 781 SDETQPGTEIINVLATDQDSGIYGTVAYELIPGNVSSLFTIDSTTGIIYLTLPLSHLEST 840
Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVI 2529
L A+D G A + V I + +F +P+++ VYE+ P + +
Sbjct: 841 TLSLMVSAQDGGGLTAVINAD----VTIHIFQTTLAPAEFERPKYTFLVYEDVPEDSPIG 896
Query: 2530 TMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLTVVATDG--G 2587
T+ A + G F + G + T++PL +E + V+ G
Sbjct: 897 TVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLD-HETQPVVVLTVQAQLG 955
Query: 2588 EPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGA 2647
P +T + + V+DVNDN P F+R + + I + P + +Y A D+D G NG
Sbjct: 956 SAPACSSTEVNITVMDVNDNHPAFLRTSDE--IRISQTTPPGTALYLARAEDRDSGRNGL 1013
Query: 2648 VRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQP 2707
+RYS F ID G++ L Q +L L A D G P +
Sbjct: 1014 IRYSIASPQPG----VFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQGVH-PQAALLV 1068
Query: 2708 LQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYF 2767
L V +E + + YQ+ SP ++ + + + Y
Sbjct: 1069 LTVVIEKREHSPSWTFE----HLVYQVEVSESLSPMTQMLQTQAHPLGPQRAASPL-RYS 1123
Query: 2768 IAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVAD 2826
+ + F ++P G + + R D E ++F V A W P G +
Sbjct: 1124 LEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFA-----WIPEDGFLQNVSTT-- 1176
Query: 2827 LTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
V V + D ND P F V + ++ A+D D G N + Y +L
Sbjct: 1177 -----VIVRVWDENDNSPTFLHDVLFLKVEESPVPQGVIGKITAIDMDSGKNGQLLYFLL 1231
Query: 2887 AI-HYFRALANDSEDVGQV 2904
+ +F+ N E + V
Sbjct: 1232 SDGKFFKMNPNTGELINWV 1250
Score = 213 bits (541), Expect = 3e-54
Identities = 237/821 (28%), Positives = 351/821 (42%), Gaps = 148/821 (18%)
Query: 2180 TVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
T+SV E P T++ +I A L + G +D+D P +D F V+ +TG
Sbjct: 70 TLSVDEGLPPDTLVGDIRA---GLPAAQQQEGSGFFLSEDSDDS-PLLDD-FHVHPDTGI 124
Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
+ ++RE Y + + A ++ + V DVND++P+F +
Sbjct: 125 IRTARRLDRERRDHYSFVAATLLGAV-----------VQVEIRVNDVNDHSPRFP---LD 170
Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL---DLV--PPG-YVQLEDSSAGK 2353
+ E + PGT A DPD GL YTL+ DL P G + QL + G
Sbjct: 171 SLQLDVSELSPPGTAFRLPVAHDPDAGLFSTQGYTLVQPSDLPKDPAGPFFQLRYRTPGP 230
Query: 2354 V-----------------IANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDIN 2396
+ + R +D EE + A D G P R + V L ++D N
Sbjct: 231 LPSPLLPGSSSPLEPLDLVLLRRLDREEAAAHRLQIEAWDGGRPRRTGLLSVELRVLDEN 290
Query: 2397 DNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYS---------------L 2441
DN P+F+Q Y+ AV ED G + V ATD D G + YS L
Sbjct: 291 DNPPVFEQDEYRAAVREDAQPGAEVCRVRATDRDLGPNGFVRYSVRARQVPGAGSGGGAL 350
Query: 2442 GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLD 2501
GD + FA+ +G + V LDRE + + L A+D + +V+V I VLD
Sbjct: 351 GDA-AYFAVEELSGVVRVWRPLDREAQAWHQLVVEARDG----GAEPEVATVRVSIAVLD 405
Query: 2502 VNDCRPQ----FSKPQFSTSVYENEPAGTSVITMMATDQD------EGPNGELTYSLEGP 2551
VND RP F V E G V + +D D + GEL L G
Sbjct: 406 VNDNRPAIHVLFLTEGGVARVSEGARPGDYVARVSVSDADGDWEKEDEATGELGVGL-GD 464
Query: 2552 GVEAFHVDMDSG-------------LVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTM 2596
G + ++ G + + PL +S + + L +VATD G PPL
Sbjct: 465 GSISLSLEGGEGDFALLPGGPPGVFFLCVEGPLDRESRDLYELLLVATDAGSPPLSTEET 524
Query: 2597 LLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLK 2654
LL+ V D+ND P+F + + E + V V A+D DE G + A +RY+ ++
Sbjct: 525 LLLRVADLNDQPPLFSQQHYKA--SVSEAAAPGTVVMWVSASDADEAGSDHAWLRYTVVQ 582
Query: 2655 TA-----GNRDWEF---------FIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 2700
+ G+ + F ID SG I T + LDRE Q L +VA DLG+P
Sbjct: 583 LSAPCNLGSLQSKMVHTAECGPSFAIDSESGAISTIRTLDREVQEAVELKVVAQDLGEP- 641
Query: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP 2760
P + + ++D++DNEP+F R Q T+ EH+P G VT A DAD G
Sbjct: 642 PLSATCLVSITVDDVNDNEPIFWR------QVYNATIAEHAPVGHCFLQVT-ASDADSGL 694
Query: 2761 NAIVYYFIAAG----NEEKNFHLQP-DGCLLVLRDLDRERE-AIFSFIVKASSNRSWTPP 2814
+ Y + G + F + P DG + V +D+DRER+ A + +V+A
Sbjct: 695 YGFIEYSLYDGFLSYEAPQAFRIDPHDGQICVSQDIDRERDPATYDLLVEAKDG------ 748
Query: 2815 RGPSPTLDLVADLTLQE-VRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDA 2873
L+ Q VRV LED+ND P F + Y ++ + + G+E+I VLA D
Sbjct: 749 ----------GGLSAQAFVRVDLEDVNDNHPVFNPSTYVTSISDETQPGTEIINVLATDQ 798
Query: 2874 DIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGIL 2914
D G V Y ++ +V +FT+ S GI+
Sbjct: 799 DSGIYGTVAYELI-----------PGNVSSLFTIDSTTGII 828
Score = 122 bits (306), Expect = 6e-27
Identities = 127/483 (26%), Positives = 209/483 (43%), Gaps = 51/483 (10%)
Query: 41 LISEDTPVGSSVTQLLAQDMDN--DPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRETK 98
L+ ED P S + + A++ N +P+ + +S + F++ P G + R+PLD ET+
Sbjct: 884 LVYEDVPEDSPIGTVKAREPLNSSEPIFYRISSGDLGGKFSIHPRLGTIRTRKPLDHETQ 943
Query: 99 S--EFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNA 156
TV+ + + +VNI V DVNDN P F +RI + TP GT +++ A
Sbjct: 944 PVVVLTVQAQLGSAPACSSTEVNITVMDVNDNHPAFLRTSDEIRISQTTPPGTALYLARA 1003
Query: 157 TDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRP 215
D D G G + YS P FAID A G++ + L + LT+ A DQ P
Sbjct: 1004 EDRDSGRNGLIRYSIASPQPGVFAIDRALGVLFLNGSLGAGEQRELTLTLRAEDQG-VHP 1062
Query: 216 LSTLANLAIIITDVQDMDP--IFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRG--- 270
+ L L ++I + ++ P F +L Y + E P +T + Q + P G
Sbjct: 1063 QAALLVLTVVI-EKREHSPSWTFEHLVYQVEVSESLSP------MTQMLQTQAHPLGPQR 1115
Query: 271 ----IGYTIVSGNTNSIFALDYISGVLTLNGLLDREN-PLYSHGFILTVKGTELNDDRTP 325
+ Y++ +++F + +G + L D E+ Y+ + P
Sbjct: 1116 AASPLRYSLEPSVDSAMFGIRPYTGWIYLRRQFDYESTQTYNFRVFAWI----------P 1165
Query: 326 SDA---TVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGL 382
D V+TT + V D NDN+P F + + E + V + I +D D G
Sbjct: 1166 EDGFLQNVSTTVIVRVWDENDNSPTFLHDVLFLKVEE-SPVPQGVIGKITAIDMDS--GK 1222
Query: 383 NSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD-LFANESVPDHV 441
N +Y + ++ F ++P + + + + LD E ++ L + P
Sbjct: 1223 NGQL-LYFLLSDGKFFKMNPNTGE------LINWVALDREHRGHHEMTVLVTDRGSPPRN 1275
Query: 442 GYAKVKITLINENDNRPIFSQPL----YNISLYENVTVGTSVLTVLATDNDAGTFGEVSY 497
V +++ + NDNRP F Q L ++ + E V V TV A D D G EV+Y
Sbjct: 1276 ATMAVYVSVTDINDNRPFFPQCLPGKELHVKVLEGQPVNMLVTTVFAKDPDEGNNAEVTY 1335
Query: 498 FFS 500
S
Sbjct: 1336 SVS 1338
>gi|16933559 protocadherin LKC precursor [Homo sapiens]
Length = 1310
Score = 323 bits (827), Expect = 2e-87
Identities = 307/1029 (29%), Positives = 474/1029 (46%), Gaps = 94/1029 (9%)
Query: 38 TYLLISEDTPVGSSVTQLLAQDMDNDPLVFGVSGEEASRFFAVEPDTGVVWLRQPLDRET 97
T +++ ED PVG+ L+A+D DNDPL +G+SG A FFAV P TG V L LD ET
Sbjct: 31 TSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNAY-FFAVTPKTGEVKLASALDYET 89
Query: 98 KSEFTVEFSVSDHQGVITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNAT 157
F V SVSD + R++ + V D NDNAP F N +S I E PVG+ +F V A
Sbjct: 90 LYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAV 149
Query: 158 DPDLGAGGSVLYSFQP------PSQFFAIDSARGIVTVIRELDYETTQA-YQLTVNATD- 209
D D+G+ G V+YS + S+ A G + + L Y A YQL + A D
Sbjct: 150 DKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDL 209
Query: 210 -----QDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQD 264
T S L+I + D D+DP F+ YS ++ E + GT+V + A+D D
Sbjct: 210 GGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGD 269
Query: 265 KGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFI-LTVKGTELNDDR 323
KG + Y+I F + GV+ +NG LDRE L + + L V TE + +
Sbjct: 270 KGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNI 328
Query: 324 TPSDATVTTTFNILVIDINDNAPEF-NSSEYSVAIT-ELAQVGFA----------LPL-F 370
+A V+ + V+D+ND+ PEF N S + T E AQV F +P+
Sbjct: 329 YGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDD 388
Query: 371 IQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIR--IRVAIPLDYETVDRYD 428
+ +V D + G N F + L G ++ F +SP G A ++ +RV+ +DYE
Sbjct: 389 LTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMA 448
Query: 429 FDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL-TVLATDN 487
+ A +SV + A V I L + ND+RP F Q LY +++ E+ G+ V ++ ATD
Sbjct: 449 VQVVATDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHATDP 508
Query: 488 DAGTFGEVSYFF--SDDPDRFSLDKDTGLIMLI--ARLDYELIQRFTLTIIARDGGGEET 543
D G +G+++Y + D F +D +G + + LD E + LT+ A DGG +
Sbjct: 509 DTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSS 568
Query: 544 TGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSA 603
+ ++I++LD+NDN P +Y ++E E +V+ ++ DE N+++ ++++
Sbjct: 569 STTLQIHLLDINDNAPVV-SGSYNIFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLP- 626
Query: 604 SAFGSY-FDISLYEGYGVISVSRPLDYEQIS---NGLIYLTVMAMDAGNPPLNSTVPVTI 659
G Y + SL G++ PLD E I G I LTV+ D G P L + V VTI
Sbjct: 627 ---GPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPVLGTKVNVTI 683
Query: 660 EVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQF 719
V D NDN P F++ +Y +V E G V + A D D++ + S S G+ F
Sbjct: 684 TVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGVVKAWDADQTEANNRISFSLSGSGANYF 742
Query: 720 RINA---RSG------EITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLD 770
I +G + LD ET+ + L V A + + I V + + D
Sbjct: 743 MIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSAENPDPQGGET--IVDVCVNVKD 800
Query: 771 INDNHPTWKDAPYY-INLVEMTPPDSDVTTVVAVDPDLGENGTL-VYSIQPPNKFYSLNS 828
+NDN PT A I + E V VVA D D + + +I + S
Sbjct: 801 VNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGS 860
Query: 829 TT----GKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPP--LKATSSATVFVNLLD 882
+++ +EA + +VV D P +++ ++ + + D
Sbjct: 861 LCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIED 920
Query: 883 LNDNDPTF--QNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLI 940
+NDN P F +N FV + E + + V A D D G NG++ + + R+DF+
Sbjct: 921 VNDNAPYFLPENKTFVI-IPELVLPNREVASVRARDDDSGNNGVILF----SILRVDFIS 975
Query: 941 NSS--------------------SGVVVTTTELDRERIAEYQLRVVASDAGT--PTKSST 978
+G + T LD YQ+ V A D + P +T
Sbjct: 976 KDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTVQARDRPSLGPFLEAT 1035
Query: 979 STLTIHVLD 987
+TL + +D
Sbjct: 1036 TTLNLFTVD 1044
Score = 229 bits (585), Expect = 3e-59
Identities = 282/1027 (27%), Positives = 441/1027 (42%), Gaps = 121/1027 (11%)
Query: 1324 ENLALGTEIVRVQAYSIDNLNQITYRF---NAYTSTQAKALFKIDAITGVITVQGLVDRE 1380
E+L +G + + A DN + +TY NAY F + TG + + +D E
Sbjct: 37 EDLPVGAQAFWLVAEDQDN-DPLTYGMSGPNAY-------FFAVTPKTGEVKLASALDYE 88
Query: 1381 KGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT 1440
YT V P + ++ + V D NDN+P F T+ S SI E PVG V +
Sbjct: 89 T--LYTFKVTISVSDPYIQVQREMLVIVEDRNDNAPVFQNTAFST-SINETLPVGSVVFS 145
Query: 1441 VKAWDPDAGSNGQVVFSL-----ASGNIAGAFEIVTTNDSIGEVFVARPLD-REELDHYI 1494
V A D D GS G VV+S+ ++G+ F I+ G + + L + Y
Sbjct: 146 VLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILAN----GSIVLNGSLSYNNKSAFYQ 201
Query: 1495 LQVVASDRG-------TPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAV 1547
L++ A D G T L ++++D D P F Y+ SV E+ GT+V
Sbjct: 202 LELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREF-YSASVAEDAAKGTSV 260
Query: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMD-----RISGEIATRPAPPDRERQSFYHL 1602
+ V A D D GIN + Y I+ + F + R++G + R + + + +
Sbjct: 261 LTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRVNGSL-DREQLLEADEEVQLQV 319
Query: 1603 VATVEDEGTPTLSATTHVYVTI--VDENDNAPMFQ--------------QPHYEVLLDE- 1645
AT A ++VT+ +D ND+ P F Q ++ +DE
Sbjct: 320 TATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEH 379
Query: 1646 GPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEIS-- 1703
+ +T+ D D+G NGT ++ G F + +A+ ++ +S
Sbjct: 380 ASPRIPIDDLTMVVYDPDKGSNGTFLLSL-GGPDAEAFSVSPERAAGSASVQVLVRVSAL 438
Query: 1704 --HGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGP 1761
+ R T + +S S V +++ DIND+ PTFP+ V E
Sbjct: 439 VDYERQTAMAVQVVATDSVSQNF-SVAMVTIHLRDINDHRPTFPQSLY-VLTVPEHSATG 496
Query: 1762 RVWTFLAH--DRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNL 1819
V T H D D+G GQ+ YS++ G+ F + PV G + VR LDRE+ A Y L
Sbjct: 497 SVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYL 556
Query: 1820 TICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
T+ A D G LSS+ + I +LDINDN PV+ NI + E S +D
Sbjct: 557 TLQATDGG--NLSSSTTLQIHLLDINDNAPVVSG-SYNIFVQEEEGNVSVTIQAHDNDEP 613
Query: 1880 SGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIP-----EYKLTISVKDNPEN 1934
N+RL FN+ G F ++ TG++ PLDRE I LT+ V D E
Sbjct: 614 GTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGE- 672
Query: 1935 PRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQ-D 1993
P + + + I + D NDN P+F +S+Y V E P VL G + A DADQ +
Sbjct: 673 PVLGTKVN--VTITVEDINDNLPIFNQSSYNFTVKEEDPG-----VLVGVVKAWDADQTE 725
Query: 1994 IYAVVTYQLLGAQSGLFDINS-------STGVVTVRSGVIIDREAFSPPILELLLLAE-- 2044
+++ L G+ + F I + G + + V +D E + P+ L + AE
Sbjct: 726 ANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYE--TQPVFNLTVSAENP 783
Query: 2045 DIGLLNSTAHLLITILDDNDNRPTFSPATLT-VHLLENCPPGFSVLQVTATDEDSGLNGE 2103
D + + + + D NDN PT A+L + + EN V V A+D D+ E
Sbjct: 784 DPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLE 843
Query: 2104 L----VYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQESY----------RLTVVATDR 2149
+ + +AG L V G+ I++ + Y R +ATD
Sbjct: 844 IQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDP 903
Query: 2150 GTVPLSGTAIVTILIDDINDSRPEFLNPIQT-VSVLESAEPGTVIANITAIDHDL--NPK 2206
G S + I I+D+ND+ P FL +T V + E P +A++ A D D N
Sbjct: 904 GFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDDSGNNGV 963
Query: 2207 LEYHI--VGIVAKDDTDRLVPNQEDAFAV------NINTGSVMVKSPMNRELVATYEVTL 2258
+ + I V ++KD +P Q F++ ++ GS+ + ++ L TY+VT+
Sbjct: 964 ILFSILRVDFISKDGA--TIPFQ-GVFSIFTSSEADVFAGSIQPVTSLDSTLQGTYQVTV 1020
Query: 2259 SVIDNAS 2265
D S
Sbjct: 1021 QARDRPS 1027
Score = 226 bits (576), Expect = 3e-58
Identities = 313/1247 (25%), Positives = 518/1247 (41%), Gaps = 172/1247 (13%)
Query: 1985 ILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
++A D D D +TY + G + F + TG V + S +D E ++ +
Sbjct: 48 LVAEDQDND---PLTYGMSGPNAYFFAVTPKTGEVKLASA--LDYETLYT--FKVTISVS 100
Query: 2045 DIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGEL 2104
D + +L+ + D NDN P F + + E P G V V A D+D G G +
Sbjct: 101 D-PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKDMGSAGMV 159
Query: 2105 VYRIE-----AGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRG-------TV 2152
VY IE G + L G I + + + Y+L + A D G T+
Sbjct: 160 VYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTI 219
Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
S ++I + D D P+F+ + SV E A GT + + A+D D +N + Y
Sbjct: 220 QCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYS 279
Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRE--LVATYEVTLSVIDNASDL- 2267
I + P D A G + V ++RE L A EV L V + L
Sbjct: 280 I--------SYSTRPGWFDIGA----DGVIRVNGSLDREQLLEADEEVQLQVTATETHLN 327
Query: 2268 ---PERSVSVPNAKLTVNVLDVNDNTPQFKPFGI---TYYMER--------ILEGATPGT 2313
E VS+ +TV V+DVND+ P+F + T+ E + E A+P
Sbjct: 328 IYGQEAKVSI---WVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRI 384
Query: 2314 TL--IAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGK------VIANRTVDYEEV 2365
+ + + DPDKG NG +L + + +AG V + VDYE
Sbjct: 385 PIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSALVDYERQ 444
Query: 2366 HWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIIL-TV 2424
+ V A+D+ S + + V + + DIND+ P F Q Y V E G+++ ++
Sbjct: 445 TAMAVQVVATDSVSQNFSVAM-VTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSI 503
Query: 2425 TATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSS--LDREKKDHYILTALAKDN 2480
ATD D+G + I YSL G+G F ++P +G + V + LDRE + Y LT A D
Sbjct: 504 HATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDG 563
Query: 2481 PGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGP 2540
G+++S S + I +LD+ND P S S +++ E G +T+ A D DE
Sbjct: 564 -GNLSS-----STTLQIHLLDINDNAPVVSG---SYNIFVQEEEGNVSVTIQAHDNDEPG 614
Query: 2541 --NGELTYSL-EGPGVEAFHVDMDSGLVTTQRPLQSYE-------KFSLTVVATDGGEPP 2590
N L ++L GP F +D D+GL+ PL + LTV+ +D GEP
Sbjct: 615 TNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRIVLTVLVSDCGEPV 674
Query: 2591 LWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIP-LRSNVYEVYATDKDEGLNGAVR 2649
L + + V D+NDN P+F + ++EE P + V + + D+ E N +
Sbjct: 675 LGTKVNVTITVEDINDNLPIFNQSSYN--FTVKEEDPGVLVGVVKAWDADQTEA-NNRIS 731
Query: 2650 YSFLKTAGNRDWEFFIIDPI---SGLIQTAQRL------DRESQAVYSLILVASDLGQPV 2700
+S + N +F+I + +G + RL D E+Q V++L V+++ P
Sbjct: 732 FSLSGSGAN----YFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLT-VSAENPDPQ 786
Query: 2701 PYETMQPLQVALEDIDDNEPLF-------VRPPKGSPQYQLLTVPEHSPRGT-------L 2746
ET+ + V ++D++DN P +R + Q+ + V S T L
Sbjct: 787 GGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVDTSAQLEIQL 846
Query: 2747 VGNVTGAVDADEGPNAIVYYFIAAG-----NEEKNFHLQP-DGCLLVLRDLDREREAIFS 2800
V + D G ++ +AA N+ K + D LV+R D + F
Sbjct: 847 VNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRACDLATDPGF- 905
Query: 2801 FIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAK 2860
+A SN + + +ED+ND P F T + +
Sbjct: 906 ---QAYSNNG--------------------SLLITIEDVNDNAPYFLPENKTFVIIPELV 942
Query: 2861 VGS-ELIQVLALDADIGNNSLVFYSILAIHYFR--ALANDSEDVGQVFTMGSMD---GIL 2914
+ + E+ V A D D GNN ++ +SIL + + + V +FT D G +
Sbjct: 943 LPNREVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSI 1002
Query: 2915 RTFDLFMAYSPGYFVVDIVARDLAGHND----TAIIGIYILRDDQRVKIVINEIPDRVRG 2970
+ + G + V + ARD T + ++ + R ++ + + V
Sbjct: 1003 QPVTSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEVGA 1062
Query: 2971 FEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQM 3030
+ L+ T V ++Q +D R + L + V L +D + M
Sbjct: 1063 NRQAINAALTQATRTTVYIVDIQ-DIDSAARAR-PHSYLDAYFV-FPNGSALTLDELSVM 1119
Query: 3031 IDENKEQLRNLFR-NYNVLDVQPAISVRLPDDMSALQMAIIV-LAILLFLAAMLFVLMNW 3088
I +++ L L + VL Q + D+S +++I+ L + L L ++ +
Sbjct: 1120 IRNDQDSLTQLLQLGLVVLGSQES----QESDLSKQLISVIIGLGVALLLVLVIMTMAFV 1175
Query: 3089 YYRTVHKRKLKAIVAGSAGNRGFIDIMD----MPNTNKYSFDGANPV 3131
R + RKL+A+ A + +M +P TN Y+ + ANP+
Sbjct: 1176 CVRKSYNRKLQAMKAAKEARKTAAGVMPSAPAIPGTNMYNTERANPM 1222
Score = 224 bits (571), Expect = 1e-57
Identities = 282/1043 (27%), Positives = 437/1043 (41%), Gaps = 138/1043 (13%)
Query: 787 LVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTHAMLDRENP 845
L E P + +VA D D N L Y + PN F+++ TG+++ A+
Sbjct: 35 LPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVKLASAL------ 85
Query: 846 DPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPA 905
+E K+ +SV+D P ++ V V D NDN P FQN F + E +P
Sbjct: 86 -DYETLYTFKVTISVSD---PYIQVQREMLVIVE--DRNDNAPVFQNTAFSTSINETLPV 139
Query: 906 GVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMD-----FLINSSSGVVVTTTELDRERIAE 960
G ++ V+A+D D G G+V Y + +P F I ++ +V+ + + A
Sbjct: 140 GSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAF 199
Query: 961 YQLRVVASDAG-------TPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFR 1013
YQL + A D G T S L+I V+D D P F Y+ SV+ED +
Sbjct: 200 YQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTS 259
Query: 1014 VVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEAI 1073
V+ + D D G+N + Y I+ G F +G D V+R LDRE +LEA
Sbjct: 260 VLTVEAVDGDKGINDPVIYSISYSTRPGWFDIG-ADGVIRVNGSLDREQ------LLEAD 312
Query: 1074 DNGPVGKRHTGTAT--------------VFVTVLDVNDNRPIFLQSSYEAS--VPEDIP- 1116
+ V + T T T V V V+DVND++P F S A PE+
Sbjct: 313 EE--VQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQV 370
Query: 1117 ------EGHSI-------LQLKATDADEGEFGRVWYRILHGNHGNNFRI-------HVSN 1156
+ H+ L + D D+G G + L G F + S
Sbjct: 371 NFTGYVDEHASPRIPIDDLTMVVYDPDKGSNG-TFLLSLGGPDAEAFSVSPERAAGSASV 429
Query: 1157 GLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRL 1216
+L+R +D ER ++ + V A + S V +++ DIND P F Q Y L
Sbjct: 430 QVLVRVSALVDYERQTAMAVQVVA-TDSVSQNFSVAMVTIHLRDINDHRPTFPQSLYV-L 487
Query: 1217 GLRETAGIGTSVI-VVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVN--YLD 1272
+ E + G+ V + ATD D+G G + Y +L G F++D +G + N LD
Sbjct: 488 TVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLD 547
Query: 1273 YETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEI 1332
E++ Y + + ATD + +++ +N+ V + SY + E G
Sbjct: 548 RESQAVYYLTLQATDGGNLSSSTTLQIHLLDINDNAPVV---SGSYNIFVQEE--EGNVS 602
Query: 1333 VRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDRE------KGDF 1384
V +QA+ D N FN + F +D TG++ G +DRE +G
Sbjct: 603 VTIQAHDNDEPGTNNSRLLFNLLPGPYSHN-FSLDPDTGLLRNLGPLDREAIDPALEGRI 661
Query: 1385 YTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAW 1444
+V+D G P + + V V ITV D NDN P F+ +S + ++ E+ P G V VKAW
Sbjct: 662 VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYN-FTVKEEDP-GVLVGVVKAW 719
Query: 1445 DPD-AGSNGQVVFSLASGNIAGAFEI--VTTNDSIGEVFVARPLDREELDHY---ILQVV 1498
D D +N ++ FSL SG+ A F I + E ++ P D LD+ + +
Sbjct: 720 DADQTEANNRISFSL-SGSGANYFMIRGLVLGAGWAEGYLRLPPD-VSLDYETQPVFNLT 777
Query: 1499 ASDRGTPPRKKDHILQ--VTILDINDNPPVIE--SPFGYNVSVNENVGGGTAVVQVRATD 1554
S P+ + I+ V + D+NDNPP ++ S G V+ N + G AVV D
Sbjct: 778 VSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVD 837
Query: 1555 RDIGIN-SVLSYYITEGNKDMA------FRMDRISGEIATRPAPPDRERQSFYHLVA--- 1604
+ +++ T+ D+ F + + D E LV
Sbjct: 838 TSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRAC 897
Query: 1605 -TVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLD 1663
D G S + +TI D NDNAP F + ++ N + +++A D D
Sbjct: 898 DLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRARDDD 957
Query: 1664 EGPNGTVTYAIV----------------AGNIVNTFRIDRHMGVITAAKELDYEISHGRY 1707
G NG + ++I+ +I + D G I LD + G Y
Sbjct: 958 SGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTL-QGTY 1016
Query: 1708 TLIVTATDQCPILSHRLTSTTTV 1730
+ V A D+ P L L +TTT+
Sbjct: 1017 QVTVQARDR-PSLGPFLEATTTL 1038
Score = 211 bits (538), Expect = 7e-54
Identities = 273/1075 (25%), Positives = 439/1075 (40%), Gaps = 140/1075 (13%)
Query: 669 PTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSG 726
P F V + E++ GA +L A D D + + Y + G F + ++G
Sbjct: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQDN------DPLTYGMSGPNAYFFAVTPKTG 77
Query: 727 EITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYIN 786
E+ S LD ET + + + D + ++ + + + D NDN P +++ + +
Sbjct: 78 EVKLASALDYETLYTFKVTISVSDPYIQVQRE-----MLVIVEDRNDNAPVFQNTAFSTS 132
Query: 787 LVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPD 846
+ E P S V +V+AVD D+G G +VYSI+ + +I +++ +
Sbjct: 133 INETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLS 192
Query: 847 PHEAELMRKIVVSVTDCG---RPPLKATSSATVF--VNLLDLNDNDPTFQNLPFVAEVLE 901
+ ++ + D G S VF ++++D D DP F + A V E
Sbjct: 193 YNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAE 252
Query: 902 GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERI--- 958
G S+ V A+D D+G+N V Y + R + + GV+ LDRE++
Sbjct: 253 DAAKGTSVLTVEAVDGDKGINDPVIYSISYS-TRPGWFDIGADGVIRVNGSLDREQLLEA 311
Query: 959 -AEYQLRVVASDA-----GTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREF 1012
E QL+V A++ G K S +T+ V+DVND P F+ ++ P E
Sbjct: 312 DEEVQLQVTATETHLNIYGQEAKVSI-WVTVRVMDVNDHKPEFYNC--SLPACTFTPEEA 368
Query: 1013 RVVWLNCTDN------------------DVGLNAELSYFITGGNVDGKFSVGYRDA---- 1050
+V + D D G N + G + + FSV A
Sbjct: 369 QVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEA-FSVSPERAAGSA 427
Query: 1051 ----VVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSS 1106
+VR +D E A + + A D+ ++ A V + + D+ND+RP F QS
Sbjct: 428 SVQVLVRVSALVDYERQTAMAVQVVATDS---VSQNFSVAMVTIHLRDINDHRPTFPQSL 484
Query: 1107 YEASVPEDIPEGHSIL-QLKATDADEGEFGRVWYRILHGNHGNNFRIH-VSNGLLMRGPR 1164
Y +VPE G + + ATD D G +G++ Y +L GN + F++ VS + +R
Sbjct: 485 YVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGE 544
Query: 1165 PLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGI 1224
LDRE + + L ++A D G + SS + +++ DIND APV Y+ E +
Sbjct: 545 LLDRESQAVYYLTLQA--TDGGNLSSSTTLQIHLLDINDNAPV-VSGSYNIFVQEEEGNV 601
Query: 1225 GTSVIVVQATDRDSGDGGLVNYRILSGA-----EGKFEIDESTGLIITVNYLDYET---- 1275
+ +QA D D + G N R+L F +D TGL+ + LD E
Sbjct: 602 S---VTIQAHDND--EPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPA 656
Query: 1276 -KTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVR 1334
+ ++ V +D P +V IT+ + D F+ +SY + E G +
Sbjct: 657 LEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEE-DPGVLVGV 715
Query: 1335 VQAYSIDNLNQITYRFNAYTSTQAKALFKI-DAITGVITVQGL--------VDREKGDFY 1385
V+A+ D + R + S F I + G +G +D E +
Sbjct: 716 VKAWDADQ-TEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVF 774
Query: 1386 TLTVVADDGGPKVDST-VKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAW 1444
LTV A++ P+ T V V + V D NDN P D S + + E+ +VA V A
Sbjct: 775 NLTVSAENPDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVAS 834
Query: 1445 DPDAGSNGQVVF--------SLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQ 1496
D D + ++ + G++ + V N S+ + ++ +D E D L
Sbjct: 835 DVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSV-YINQSKAIDYEACDLVTLV 893
Query: 1497 VVASDRGTPP----RKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRA 1552
V A D T P + L +TI D+NDN P V + E V V VRA
Sbjct: 894 VRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNREVASVRA 953
Query: 1553 TDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRP----------------------- 1589
D D G N V+ + I R+D IS + AT P
Sbjct: 954 RDDDSGNNGVILFSI--------LRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPV 1005
Query: 1590 APPDRERQSFYHLVATVEDEGT--PTLSATTHVYVTIVDENDNAPM-FQQPHYEV 1641
D Q Y + D + P L ATT + + VD++ + + F P EV
Sbjct: 1006 TSLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVDQSYRSRLQFSTPKEEV 1060
Score = 211 bits (536), Expect = 1e-53
Identities = 271/1001 (27%), Positives = 441/1001 (44%), Gaps = 137/1001 (13%)
Query: 1849 PVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINAT--TG 1906
P L ++ + E+ PV + ++A D D N LT+ ++ N A+F T TG
Sbjct: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPN---AYFFAVTPKTG 77
Query: 1907 IVTVNRPLDRERIPEYKLTISVKDNPENPRI-ARRDYDLLLIFLSDENDNHPLFTKSTYQ 1965
V + LD E + +K+TISV D P I +R+ +L+ + D NDN P+F + +
Sbjct: 78 EVKLASALDYETLYTFKVTISVSD----PYIQVQRE---MLVIVEDRNDNAPVFQNTAFS 130
Query: 1966 AEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQL------LGAQSGLFDINSSTGVV 2019
+ E P G+ + +LA+D D +V Y + G LF I ++ +V
Sbjct: 131 TSINETLPVGSVVF----SVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIV 186
Query: 2020 TVRSGVIIDREAFSPPILELLLLAEDIG-LLNST--------AHLLITILDDNDNRPTFS 2070
S ++ AF +L L A D+G + ++T L I+++D D P F
Sbjct: 187 LNGSLSYNNKSAF----YQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFV 242
Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNA 2130
+ + E+ G SVL V A D D G+N ++Y I + + GVIRV N
Sbjct: 243 REFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIGADGVIRV-NG 301
Query: 2131 TIDREE----QESYRLTVVATDRGTVPLSGTAIV----TILIDDINDSRPEFLN---PIQ 2179
++DRE+ E +L V AT+ A V T+ + D+ND +PEF N P
Sbjct: 302 SLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPAC 361
Query: 2180 TVSVLESAEPGTVIANITA-IDHDLNPKLEYHIVGIVAKDD------TDRLVPNQEDAFA 2232
T + P N T +D +P++ + +V D T L DA A
Sbjct: 362 TFT------PEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEA 415
Query: 2233 VNIN----TGSVMVKSPMNRELVATYE--VTLSVIDNASDLPERSVSVPNAKLTVNVLDV 2286
+++ GS V+ + + YE ++V A+D ++ SV A +T+++ D+
Sbjct: 416 FSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSV--AMVTIHLRDI 473
Query: 2287 NDNTPQFKPFGITYYMERILEGATPGTTLI-AVAAVDPDKGLNGLVTYTLLDLVPPGYVQ 2345
ND+ P F + Y+ + E + G+ + ++ A DPD G G +TY+LL Q
Sbjct: 474 NDHRPTFPQ---SLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQ 530
Query: 2346 LEDSSAGKVIAN-RTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
++ S + N +D E T++A+D G+ + + ++L +DINDN P+
Sbjct: 531 VDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGNLSSSTTLQIHL--LDINDNAPVVSG 588
Query: 2405 PSYQEAVFEDVPVGTIILTVTATDADSG--NFALIEYSL--GDGESKFAINPTTGDIYVL 2460
SY +F G + +T+ A D D N + + ++L G F+++P TG + L
Sbjct: 589 -SYN--IFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNL 645
Query: 2461 SSLDREKKD-----HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515
LDRE D +LT L D V + V V I V D+ND P F++ ++
Sbjct: 646 GPLDREAIDPALEGRIVLTVLVSDCGEPVLGTK----VNVTITVEDINDNLPIFNQSSYN 701
Query: 2516 TSVYENEPAGTSVITMMATDQDEGP-NGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSY 2574
+V E +P G V + A D D+ N +++SL G G F M GLV + Y
Sbjct: 702 FTVKEEDP-GVLVGVVKAWDADQTEANNRISFSLSGSGANYF---MIRGLVLGAGWAEGY 757
Query: 2575 EK--------------FSLTVVATDGGEPPLWGTTML--LVEVIDVNDNRPVF-VRPPNG 2617
+ F+LTV A + P G T++ V V DVNDN P V G
Sbjct: 758 LRLPPDVSLDYETQPVFNLTVSAEN--PDPQGGETIVDVCVNVKDVNDNPPTLDVASLRG 815
Query: 2618 TILHIREEIPLRSNVYEVYATDKDEGLNGAVRY-SFLKTAGNRD-----WEFFIIDPISG 2671
+ + E V V A+D D ++ + L T D W +F +
Sbjct: 816 --IRVAENGSQHGQVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGS 873
Query: 2672 L-IQTAQRLDRESQAVYSLILVASDLGQPVPYETMQ---PLQVALEDIDDNEPLFVRPPK 2727
+ I ++ +D E+ + +L++ A DL ++ L + +ED++DN P F+ K
Sbjct: 874 VYINQSKAIDYEACDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENK 933
Query: 2728 GSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFI 2768
+ +PE V +V A D D G N ++ + I
Sbjct: 934 -----TFVIIPELVLPNREVASVR-ARDDDSGNNGVILFSI 968
Score = 203 bits (516), Expect = 3e-51
Identities = 276/1029 (26%), Positives = 422/1029 (41%), Gaps = 139/1029 (13%)
Query: 1760 GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNL 1819
G + + +A D+D+ P + Y M G F ++P G +++ LD ET+ + +
Sbjct: 42 GAQAFWLVAEDQDNDP---LTYG-MSGPNAYFFAVTPKTGEVKLAS--ALDYETLYTFKV 95
Query: 1820 TICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDAD 1879
TI D P + + + V D NDN PV N + +I+E PV S V VLA D D
Sbjct: 96 TISVSD---PYIQVQREMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVLAVDKD 152
Query: 1880 SGCNARLTFNI-----TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN 1934
G + ++I + G+ E F I A IV + Y+L + D
Sbjct: 153 MGSAGMVVYSIEKVIPSTGDSEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGM 212
Query: 1935 PRIARRDYDLLLIFLS----DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDA 1990
L +FLS D+ D P F + Y A V E++ GT + + A+D
Sbjct: 213 YHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAEDAAKGTSVLTVE----AVDG 268
Query: 1991 DQDIYAVVTYQL-LGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL- 2048
D+ I V Y + + G FDI + GV+ V + ++ + ++L + A + L
Sbjct: 269 DKGINDPVIYSISYSTRPGWFDIGAD-GVIRVNGSLDREQLLEADEEVQLQVTATETHLN 327
Query: 2049 -----LNSTAHLLITILDDNDNRP----------TFSP----ATLTVHLLENCPPGFSV- 2088
+ + + ++D ND++P TF+P T ++ E+ P +
Sbjct: 328 IYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPID 387
Query: 2089 -LQVTATDEDSGLNGELVYRIEAGAQDRFLIH--------LVTGVIRVGNATIDREEQES 2139
L + D D G NG + + + F + V ++RV +A +D E Q +
Sbjct: 388 DLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPERAAGSASVQVLVRV-SALVDYERQTA 446
Query: 2140 YRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN-ITA 2198
+ VVATD + S A+VTI + DIND RP F + ++V E + G+V+ + I A
Sbjct: 447 MAVQVVATDSVSQNFS-VAMVTIHLRDINDHRPTFPQSLYVLTVPEHSATGSVVTDSIHA 505
Query: 2199 IDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSP--MNRELVATYEV 2256
D D G + L N D F V+ +G+V V++ ++RE A Y +
Sbjct: 506 TDPD---------TGAWGQITYSLLPGNGADLFQVDPVSGTVTVRNGELLDRESQAVYYL 556
Query: 2257 TLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
TL D + + L +++LD+NDN P + E G +
Sbjct: 557 TLQATDGGN-------LSSSTTLQIHLLDINDNAPVVSGSYNIFVQEE------EGNVSV 603
Query: 2317 AVAAVDPDK-GLNGLVTYTLLDLVPPGYVQ--LEDSSAGKVIANRTVDYEEVH-----WL 2368
+ A D D+ G N + L +L+P Y D G + +D E + +
Sbjct: 604 TIQAHDNDEPGTNN--SRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDREAIDPALEGRI 661
Query: 2369 NFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATD 2428
TV SD G P ++ V + + DINDN PIF+Q SY V E+ P G ++ V A D
Sbjct: 662 VLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDP-GVLVGVVKAWD 720
Query: 2429 ADSGNF-ALIEYSL-GDGESKFAINPTT-----GDIYVL----SSLDREKKDHYILTALA 2477
AD I +SL G G + F I + Y+ SLD E + + LT A
Sbjct: 721 ADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLRLPPDVSLDYETQPVFNLTVSA 780
Query: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQF-STSVYENEPAGTSVITMMATDQ 2536
+NP E V V + V DVND P V EN V ++A+D
Sbjct: 781 -ENPDPQGG---ETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDV 836
Query: 2537 DEGPNGEL---TYSLEGPGVEA-------FHVDMDSGLVTTQRPLQSYEKFSLTV----- 2581
D E+ GV+ F V + + Q YE L
Sbjct: 837 DTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEACDLVTLVVRA 896
Query: 2582 --VATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
+ATD G LL+ + DVNDN P F+ P N T + I E + V V A D
Sbjct: 897 CDLATDPGFQAYSNNGSLLITIEDVNDNAPYFL-PENKTFVIIPELVLPNREVASVRARD 955
Query: 2640 KDEGLNGAVRYSFLKTAG-NRD---------WEFFI---IDPISGLIQTAQRLDRESQAV 2686
D G NG + +S L+ ++D + F D +G IQ LD Q
Sbjct: 956 DDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVTSLDSTLQGT 1015
Query: 2687 YSLILVASD 2695
Y + + A D
Sbjct: 1016 YQVTVQARD 1024
Score = 197 bits (500), Expect = 2e-49
Identities = 227/777 (29%), Positives = 340/777 (43%), Gaps = 121/777 (15%)
Query: 2174 FLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKD-DTDRLVPNQEDA-- 2230
FL P VSV + P +AN+T++ + + +VA+D D D L
Sbjct: 9 FLLPALVVSVAANVAP-KFLANMTSVILPEDLPVGAQAFWLVAEDQDNDPLTYGMSGPNA 67
Query: 2231 --FAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
FAV TG V + S ++ E + T++VT+SV D + ++ V V D ND
Sbjct: 68 YFFAVTPKTGEVKLASALDYETLYTFKVTISVSDPYIQVQR--------EMLVIVEDRND 119
Query: 2289 NTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLED 2348
N P F+ T + I E G+ + +V AVD D G G+V Y++ ++P D
Sbjct: 120 NAPVFQN---TAFSTSINETLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIP----STGD 172
Query: 2349 S-------SAGKVIANRTVDYEEVH-WLNFTVRASDNGSPPR-----AAEIPVYLEI--V 2393
S + G ++ N ++ Y + ++A D G +PV+L I V
Sbjct: 173 SEHLFRILANGSIVLNGSLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVV 232
Query: 2394 DINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK--FAIN 2451
D D +P F + Y +V ED GT +LTV A D D G + YS+ F I
Sbjct: 233 DQPDLDPQFVREFYSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDIG 292
Query: 2452 PTTGDIYVLSSLDREK----KDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRP 2507
G I V SLDRE+ + L A + ++ + S+ V ++V+DVND +P
Sbjct: 293 -ADGVIRVNGSLDREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKP 351
Query: 2508 QF------------SKPQFSTSVYENEPAGTSV----ITMMATDQDEGPNGELTYSLEGP 2551
+F + Q + + Y +E A + +TM+ D D+G NG SL GP
Sbjct: 352 EFYNCSLPACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGP 411
Query: 2552 GVEAFHVDMD--SGLVTTQ-----RPLQSYEK---FSLTVVATDGGEPPLWGTTMLLVEV 2601
EAF V + +G + Q L YE+ ++ VVATD + M+ + +
Sbjct: 412 DAEAFSVSPERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQN-FSVAMVTIHL 470
Query: 2602 IDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE-VYATDKDEGLNGAVRYSFLKTAGNRD 2660
D+ND+RP F P + +L + E S V + ++ATD D G G + YS L G
Sbjct: 471 RDINDHRPTF--PQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGA-- 526
Query: 2661 WEFFIIDPISGLI--QTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDN 2718
+ F +DP+SG + + + LDRESQAVY L L A+D G + LQ+ L DI+DN
Sbjct: 527 -DLFQVDPVSGTVTVRNGELLDRESQAVYYLTLQATDGGN---LSSSTTLQIHLLDINDN 582
Query: 2719 EPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGP-----NAIVYYFIAAGNE 2773
P+ S Y + E GNV+ + A + N+ + + + G
Sbjct: 583 APVV------SGSYNIFVQEEE-------GNVSVTIQAHDNDEPGTNNSRLLFNLLPGPY 629
Query: 2774 EKNFHLQPD-GCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADL----- 2827
NF L PD G L L LDRE AI + G LV+D
Sbjct: 630 SHNFSLDPDTGLLRNLGPLDRE--AIDPAL------------EGRIVLTVLVSDCGEPVL 675
Query: 2828 -TLQEVRVVLEDINDQPPRFTKAEYTAGV-ATDAKVGSELIQVLALDADIGNNSLVF 2882
T V + +EDIND P F ++ Y V D V +++ D NN + F
Sbjct: 676 GTKVNVTITVEDINDNLPIFNQSSYNFTVKEEDPGVLVGVVKAWDADQTEANNRISF 732
Score = 196 bits (498), Expect = 3e-49
Identities = 228/877 (25%), Positives = 387/877 (44%), Gaps = 132/877 (15%)
Query: 2067 PTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIR 2126
P F +V L E+ P G + A D+D N L Y + F + TG ++
Sbjct: 24 PKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEVK 80
Query: 2127 VGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLES 2186
+ +A +D E ++++T+ +D + + ++++D ND+ P F N + S+ E+
Sbjct: 81 LASA-LDYETLYTFKVTISVSDPY---IQVQREMLVIVEDRNDNAPVFQNTAFSTSINET 136
Query: 2187 AEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDA---FAVNINTGSVMVK 2243
G+V+ ++ A+D D+ G+V ++++P+ D+ F + N V+
Sbjct: 137 LPVGSVVFSVLAVDKDMGS------AGMVVYS-IEKVIPSTGDSEHLFRILANGSIVLNG 189
Query: 2244 SPMNRELVATYEVTLSVIDNASDLPER---SVSVPNAKLTVNVLDVNDNTPQFKPFGITY 2300
S A Y++ L D S+P L+++V+D D PQF +
Sbjct: 190 SLSYNNKSAFYQLELKACDLGGMYHNTFTIQCSLP-VFLSISVVDQPDLDPQFVR---EF 245
Query: 2301 YMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTV 2360
Y + E A GT+++ V AVD DKG+N V Y++ PG+ + + G + N ++
Sbjct: 246 YSASVAEDAAKGTSVLTVEAVDGDKGINDPVIYSISYSTRPGWFDI--GADGVIRVNGSL 303
Query: 2361 DYEEVH------WLNFTVRASDNGSPPRAAEIPVYL--EIVDINDNNPIFDQPSYQEAVF 2412
D E++ L T + + A++ +++ ++D+ND+ P F S F
Sbjct: 304 DREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEFYNCSLPACTF 363
Query: 2413 ED------------------VPVGTIILTVTATDADSGNFALIEYSLGDGESK-FAINPT 2453
+P+ LT+ D D G+ SLG +++ F+++P
Sbjct: 364 TPEEAQVNFTGYVDEHASPRIPIDD--LTMVVYDPDKGSNGTFLLSLGGPDAEAFSVSPE 421
Query: 2454 TGD--------IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDC 2505
+ V + +D E++ + +A D+ ++ + V I + D+ND
Sbjct: 422 RAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSV-----SQNFSVAMVTIHLRDINDH 476
Query: 2506 RPQFSKPQFSTSVYENEPAGTSVI-TMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSG 2563
RP F + + +V E+ G+ V ++ ATD D G G++TYSL G G + F VD SG
Sbjct: 477 RPTFPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNGADLFQVDPVSG 536
Query: 2564 LVTTQR----PLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI 2619
VT + +S + LT+ ATDGG L +T L + ++D+NDN PV N
Sbjct: 537 TVTVRNGELLDRESQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPVVSGSYN--- 591
Query: 2620 LHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRL 2679
+ ++EE S + + D+ N + ++ L + + F +DP +GL++ L
Sbjct: 592 IFVQEEEGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHN---FSLDPDTGLLRNLGPL 648
Query: 2680 DRES-----QAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL 2734
DRE+ + L ++ SD G+PV T + + +EDI+DN P+F Y
Sbjct: 649 DREAIDPALEGRIVLTVLVSDCGEPV-LGTKVNVTITVEDINDNLPIF-----NQSSYNF 702
Query: 2735 LTVPEHSPRGTLVGNVTGAVDAD--EGPNAIVY--------YF------IAAGNEEKNFH 2778
TV E P G LVG V A DAD E N I + YF + AG E
Sbjct: 703 -TVKEEDP-GVLVG-VVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYLR 759
Query: 2779 LQPDGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLED 2838
L PD LD E + +F+ V A + P+G T+ +V V ++D
Sbjct: 760 LPPDV------SLDYETQPVFNLTVSAEN----PDPQGGE---------TIVDVCVNVKD 800
Query: 2839 INDQPPRFTKAEYTA-GVATDAKVGSELIQVLALDAD 2874
+ND PP A VA + ++ V+A D D
Sbjct: 801 VNDNPPTLDVASLRGIRVAENGSQHGQVAVVVASDVD 837
Score = 185 bits (469), Expect = 7e-46
Identities = 266/1058 (25%), Positives = 439/1058 (41%), Gaps = 128/1058 (12%)
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ-PPSQFFAIDSARGIV 187
AP F SV +PE+ PVG F + A D D + Y P + FFA+ G V
Sbjct: 23 APKFLANMTSVILPEDLPVGAQAFWLVAEDQD---NDPLTYGMSGPNAYFFAVTPKTGEV 79
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYE 247
+ LDYET +++T++ +D + + +I+ D D P+F N +ST+I E
Sbjct: 80 KLASALDYETLYTFKVTISVSDP----YIQVQREMLVIVEDRNDNAPVFQNTAFSTSINE 135
Query: 248 HSPPGTTVRIITAIDQDKGRPRGIGYTI-----VSGNTNSIFALDYISGVLTLNGLLDRE 302
P G+ V + A+D+D G + Y+I +G++ +F + +G + LNG L
Sbjct: 136 TLPVGSVVFSVLAVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYN 194
Query: 303 NPLYSHGFILTVKGTELN---DDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITE 359
N S + L +K +L + ++ +I V+D D P+F YS ++ E
Sbjct: 195 NK--SAFYQLELKACDLGGMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSASVAE 252
Query: 360 LAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPL 419
A G ++ L ++ VD D+ G+N +Y + ++ P AD IRV L
Sbjct: 253 DAAKGTSV-LTVEAVDGDK--GINDPV-IYSISYSTR-----PGWFDIGADGVIRVNGSL 303
Query: 420 DYETV----DRYDFDLFANESVPDHVGY-AKVKI----TLINENDNRPIFSQPLYNISL- 469
D E + + + A E+ + G AKV I +++ ND++P F YN SL
Sbjct: 304 DREQLLEADEEVQLQVTATETHLNIYGQEAKVSIWVTVRVMDVNDHKPEF----YNCSLP 359
Query: 470 -------------------YENVTVGTSVLTVLATDNDAGTFGE-VSYFFSDDPDRFSLD 509
+ + + LT++ D D G+ G + D + FS+
Sbjct: 360 ACTFTPEEAQVNFTGYVDEHASPRIPIDDLTMVVYDPDKGSNGTFLLSLGGPDAEAFSVS 419
Query: 510 KDTG--------LIMLIARLDYELIQRFTLTIIARDGGGEE-TTGRVRINVLDVNDNVPT 560
+ L+ + A +DYE + ++A D + + V I++ D+ND+ PT
Sbjct: 420 PERAAGSASVQVLVRVSALVDYERQTAMAVQVVATDSVSQNFSVAMVTIHLRDINDHRPT 479
Query: 561 FQKDAYVGALRENEPSVTQLV-RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYG 619
F + YV + E+ + + + + ATD D+ QITYS++ + F + G
Sbjct: 480 FPQSLYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLLPGNG-ADLFQVDPVSGTV 538
Query: 620 VISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVS 679
+ LD E S + YLT+ A D GN L+S+ + I + D NDN P S +Y +
Sbjct: 539 TVRNGELLDRE--SQAVYYLTLQATDGGN--LSSSTTLQIHLLDINDNAPVVS-GSYNIF 593
Query: 680 VVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG--STQFRINARSGEITTTSLLDRE 737
V E G + + A D D + L G S F ++ +G + LDRE
Sbjct: 594 VQEE--EGNVSVTIQAHDNDEPGTNNSRLLFNLLPGPYSHNFSLDPDTGLLRNLGPLDRE 651
Query: 738 T---KSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPD 794
E +++ + G V IT+ DINDN P + + Y + E P
Sbjct: 652 AIDPALEGRIVLTVLVSDCGEPVLGTKVNVTITVEDINDNLPIFNQSSYNFTVKE-EDPG 710
Query: 795 SDVTTVVAVDPDLGE-NGTLVYSIQPPN-KFYSLNSTTGKIRTTHAMLDRENPD---PHE 849
V V A D D E N + +S+ ++ + L R PD +E
Sbjct: 711 VLVGVVKAWDADQTEANNRISFSLSGSGANYFMIRGLVLGAGWAEGYL-RLPPDVSLDYE 769
Query: 850 AELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQ--NLPFVAEVLEGIPAGV 907
+ + + VS + P + V VN+ D+NDN PT +L + G G
Sbjct: 770 TQPVFNLTVSAEN--PDPQGGETIVDVCVNVKDVNDNPPTLDVASLRGIRVAENGSQHG- 826
Query: 908 SIYQVVAIDLDEG------LNGLVSYRMPVGMPRMD---FLINSSSGVVVTTTE-LDRER 957
+ VVA D+D L ++ + V + + F + ++ V + ++ +D E
Sbjct: 827 QVAVVVASDVDTSAQLEIQLVNILCTKAGVDVGSLCWGWFSVAANGSVYINQSKAIDYEA 886
Query: 958 IAEYQLRV----VASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYN-VSVSEDVPREF 1012
L V +A+D G S+ +L I + DVND P F P V + E V
Sbjct: 887 CDLVTLVVRACDLATDPGFQAYSNNGSLLITIEDVNDNAPYFLPENKTFVIIPELVLPNR 946
Query: 1013 RVVWLNCTDNDVGLNAELSYFI--------TGGNV--DGKFSVGYRDAV------VRTVV 1056
V + D+D G N + + I G + G FS+ ++ V
Sbjct: 947 EVASVRARDDDSGNNGVILFSILRVDFISKDGATIPFQGVFSIFTSSEADVFAGSIQPVT 1006
Query: 1057 GLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLD 1094
LD Y + ++A D +G T T+ + +D
Sbjct: 1007 SLDSTLQGTYQVTVQARDRPSLGPFLEATTTLNLFTVD 1044
Score = 92.8 bits (229), Expect = 5e-18
Identities = 127/518 (24%), Positives = 209/518 (40%), Gaps = 77/518 (14%)
Query: 2413 EDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYI 2472
ED+PVG + A D D N L G FA+ P TG++ + S+LD E +
Sbjct: 37 EDLPVGAQAFWLVAEDQD--NDPLTYGMSGPNAYFFAVTPKTGEVKLASALDYETLYTFK 94
Query: 2473 LTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM 2532
+T D V ++++ V D ND P F FSTS+ E P G+ V +++
Sbjct: 95 VTISVSDPYIQVQR-------EMLVIVEDRNDNAPVFQNTAFSTSINETLPVGSVVFSVL 147
Query: 2533 ATDQDEGPNGELTYSLE------GPGVEAFHVDMDSGLVTTQRPLQSYEK---FSLTVVA 2583
A D+D G G + YS+E G F + + +G + L K + L + A
Sbjct: 148 AVDKDMGSAGMVVYSIEKVIPSTGDSEHLFRI-LANGSIVLNGSLSYNNKSAFYQLELKA 206
Query: 2584 TDGGEPPLWGTT---------MLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634
D G ++ T L + V+D D P FVR + E+ ++V
Sbjct: 207 CDLG--GMYHNTFTIQCSLPVFLSISVVDQPDLDPQFVREFYSA--SVAEDAAKGTSVLT 262
Query: 2635 VYATDKDEGLNGAVRYSFLKTAGNRDWEFFI----IDPISGLIQTAQRLDRESQAVYSLI 2690
V A D D+G+N V YS + R F I + ++G + Q L+ + + +
Sbjct: 263 VEAVDGDKGINDPVIYSI--SYSTRPGWFDIGADGVIRVNGSLDREQLLEADEEVQLQVT 320
Query: 2691 LVASDL---GQPVPYETMQPLQVALEDIDDNEPLFVR--------PPKGSPQYQLLTVPE 2739
+ L GQ + V + D++D++P F P+ + V E
Sbjct: 321 ATETHLNIYGQEAKVSIW--VTVRVMDVNDHKPEFYNCSLPACTFTPEEAQVNFTGYVDE 378
Query: 2740 HSPRGTLVGNVTGAV-DADEGPNAIVYYFIAAGNEEKNFHLQPDGC---------LLVLR 2789
H+ + ++T V D D+G N + G + + F + P+ + V
Sbjct: 379 HASPRIPIDDLTMVVYDPDKGSNG-TFLLSLGGPDAEAFSVSPERAAGSASVQVLVRVSA 437
Query: 2790 DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKA 2849
+D ER+ + V A+ + S + ++ V + L DIND P F ++
Sbjct: 438 LVDYERQTAMAVQVVATDSVS--------------QNFSVAMVTIHLRDINDHRPTFPQS 483
Query: 2850 EYTAGVATDAKVGSELI-QVLALDADIGNNSLVFYSIL 2886
Y V + GS + + A D D G + YS+L
Sbjct: 484 LYVLTVPEHSATGSVVTDSIHATDPDTGAWGQITYSLL 521
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 305 bits (782), Expect = 4e-82
Identities = 338/1179 (28%), Positives = 534/1179 (45%), Gaps = 139/1179 (11%)
Query: 224 IIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGR------PRG-----IG 272
I++ D D P F + Y + E +P GTT I T D G P G I
Sbjct: 140 IVVRDRNDNSPTFKHESYYATVNELTPVGTT--IFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 273 YTIVSGNTNSIFALDY-ISGVLTLNGLLDRENPLYSHGFI-LTVKGTELNDDRTPSDATV 330
Y +N F + ++G + L L+ E+ I + LN+ RT
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRT-----T 252
Query: 331 TTTFNILVIDINDNAPEF-------NSSE-----YSVAITELAQVGFALPLF----IQVV 374
TTT + V+D +D P F N+ + Y AI EL P+ IQ +
Sbjct: 253 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312
Query: 375 DKDENLGLNS----MFEVYLVGNNSHH---FIISPTSVQGKADIRIRVAIPLDYETVDRY 427
D+D N+ S + LVG + F + P + + + + P++ + ++
Sbjct: 313 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAE------LSLLEPVNRDFHQKF 366
Query: 428 DFDLFANESVPDHV-GYAKVKITLINENDNRPIFSQPLYNISLYENVTVG---------T 477
D + A + + +A + I +++EN+ P F+ P Y + E+ VG T
Sbjct: 367 DLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLT 426
Query: 478 SVLTVLATDNDAGTFG---------EVSYFFSDDPDRFSLDKD--TGLIMLIARLDYELI 526
S L ++A D D E+ F +D F++ + T + L+ +D E
Sbjct: 427 SPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQ 486
Query: 527 QRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRAT 586
Q +T +I A DG E V I V+D NDN PTF + +Y + + +++L A
Sbjct: 487 QTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAV 546
Query: 587 DEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDA 646
D D N +ITY I+ G+ D + + G+I+++ + E I LTV A D
Sbjct: 547 DADEGSNGEITYEIL----VGAQGDFIINKTTGLITIAPGV--EMIVGRTYALTVQAADN 600
Query: 647 GNPP--LNSTVPVTIEVFDEND-NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSRE 703
P NS V IEV N+ +PP F + Y + + E + GA +L L ATD +
Sbjct: 601 APPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG--- 657
Query: 704 YGQESIIYSLE-GSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTG 760
+SI Y++E G Q F ++ +G +T LDRE+ YILI+ A DG T
Sbjct: 658 ---DSITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDG---RPDGTS 711
Query: 761 IATVNITLLDINDNHPTWKD-APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQP 819
ATVNI + D+NDN P + P +++VE ++ V V A DPD G NG + YS+
Sbjct: 712 TATVNIVVTDVNDNAPVFDPYLPRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSLGN 770
Query: 820 PNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVN 879
N + + S G I T L+RE D +E +VV TD P +T T+ +
Sbjct: 771 FNNLFRITSN-GSIYTA-VKLNREVRDYYE------LVVVATDGAVHPRHST--LTLAIK 820
Query: 880 LLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFL 939
+LD++DN P F N + V E +PAG +I Q+ A D+D G N VSYR+ + F
Sbjct: 821 VLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFA 878
Query: 940 INSSSGVVVTTTELDRERIAEYQLRVV----ASDAGTPTKSSTSTLTIHVLDVNDETPTF 995
++ +G + LD E + + + A D +T+T+ V D+ND P F
Sbjct: 879 LHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVF 938
Query: 996 FPAVYNVSVSEDVPREFRVVWLNCTDNDV-GLNAE-LSYFITGGNVD---GKFSVGYRDA 1050
+Y V+ D + + + D D GL A + Y + F V
Sbjct: 939 SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSG 998
Query: 1051 VVRTVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEA 1109
V T V L+ E T + L++ A D+G PV + +ATV + VL + P F Q Y
Sbjct: 999 RVITRVNLNEEPTTIFKLVVVAFDDGEPV---MSSSATVKILVLHPGEI-PRFTQEEYRP 1054
Query: 1110 S-VPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDR 1168
V E +G + + A ++ + Y I+ GN + F I+ G++ PLD
Sbjct: 1055 PPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNG-PLDY 1109
Query: 1169 ERNSSHVLIVEAYNHDLG------PMRSSV-RVIVYVEDINDEAPVFTQQQYSRLGLRET 1221
E +S+VL V+A + ++ P +S+ +V + ++D N+ PVF ++ Y G+ E
Sbjct: 1110 ETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG-GVSED 1168
Query: 1222 AGIGTSVIVVQATDRDSGDGGLVNYRIL-----SGAEGKFEIDESTGLIITVNYLDYETK 1276
A + TSV+ V+ATD+D+G+ ++ YR++ G EG F ++ TGLI T +
Sbjct: 1169 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRR 1227
Query: 1277 TSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN 1315
+ + V ATD G V ++++N+LD V SN
Sbjct: 1228 SYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1266
Score = 295 bits (754), Expect = 7e-79
Identities = 317/1180 (26%), Positives = 516/1180 (43%), Gaps = 122/1180 (10%)
Query: 833 IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN 892
+ +T +LDR+ P + IVV V C + V + + D NDN PTF++
Sbjct: 101 LNSTGRVLDRDPPMN-----IHSIVVQV-QCINKKVGTIIYHEVRIVVRDRNDNSPTFKH 154
Query: 893 LPFVAEVLEGIPAGVSIYQVV-----AIDLDEGLNGLVSYRM------PVGMPRMDFLIN 941
+ A V E P G +I+ A D+D+G NG + Y + P + +
Sbjct: 155 ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPL- 213
Query: 942 SSSGVVVTTTELDRERIAEYQLRVVASDAG---TPTKSSTSTLTIHVLDVNDETPTFFPA 998
+G +V L+ E Y + + A+D +++T+TLT+ VLD +D P F P
Sbjct: 214 MLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPC 273
Query: 999 V------------YNVSVSE-DVPREFRVVW----LNCTDNDVGLNAE-----LSYFITG 1036
V Y ++ E P E + + D D + + Y I
Sbjct: 274 VLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILV 333
Query: 1037 GNVDGK---FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVL 1093
G + F + R A + + ++R+ + L+++A + G A + + +L
Sbjct: 334 GTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN--GHPLPAFAGLHIEIL 391
Query: 1094 DVNDNRPIFLQSSYEASVPEDIPEGHSI---------LQLKATDADEGEFGRVWY----- 1139
D N+ P F SY+ + E P G +I L++ A D D +
Sbjct: 392 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDP 451
Query: 1140 --RILHGNHGNNFRIHVSNGLL--MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSS-VRV 1194
+ ++ + F + G+ + +P+DRE ++ + A++ G S V V
Sbjct: 452 ELHLFLNDYTSVFTV-TQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIV 507
Query: 1195 IVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEG 1254
+ V D ND P F + Y + G SVI + A D D G G + Y IL GA+G
Sbjct: 508 NIQVMDANDNTPTFPEISYDVYVYTDMRP-GDSVIQLTAVDADEGSNGEITYEILVGAQG 566
Query: 1255 KFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQ--GFCSVYITLLNELDEAV- 1311
F I+++TGLI ++ +Y + V A D APP + C+VYI +L +++
Sbjct: 567 DFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPP 626
Query: 1312 QFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVI 1371
+F Y I E + +G ++ +QA + + ITY A + + +F + TG++
Sbjct: 627 RFPQLMYSLEISEAMRVGAVLLNLQATDREG-DSITY---AIENGDPQRVFNLSETTGIL 682
Query: 1372 TVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPED 1431
T+ +DRE D Y L + A DG P ST V I V D NDN+P FD +S+ E+
Sbjct: 683 TLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE 742
Query: 1432 CPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELD 1491
V VKA DPDAG NGQV +SL GN F I S G ++ A L+RE D
Sbjct: 743 -EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRIT----SNGSIYTAVKLNREVRD 795
Query: 1492 HYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVR 1551
+Y L VVA+D PR L + +LDI+DN PV + Y V V EN+ GT ++Q+
Sbjct: 796 YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS-TYTVLVEENLPAGTTILQIE 854
Query: 1552 ATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIA-----TRPAPPDRERQSFYHLVATV 1606
A D D+G N +SY I F + +GE++ A PD+E S LV
Sbjct: 855 AKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE-ASITFLVEAF 911
Query: 1607 EDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTL-NTSLITIQALDLDEG 1665
+ GT T V V + D ND P+F + Y+ ++ PD + T + T+ A D D
Sbjct: 912 DIYGTMPPGIAT-VTVIVKDMNDYPPVFSKRIYKGMV--APDAVKGTPITTVYAEDADPP 968
Query: 1666 --PNGTVTYAIVAGNI---VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPIL 1720
P V Y + + F ++ G + L+ E + ++V D P++
Sbjct: 969 GLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVM 1028
Query: 1721 SHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE-GQPGPRVWTFLAHDRDSGPNGQV 1779
S S+ TV + V + +P F ++ P V+E G V A + N +
Sbjct: 1029 S----SSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSI 1079
Query: 1780 EYSIMDGDPLGEFVISPVEGVLRVRKDVELDRET-----IAFYNLTICARDRGMPPLSST 1834
YSI+ G+ F I+ + GV+ V ++ + T + +L + + +P S+T
Sbjct: 1080 VYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNT 1139
Query: 1835 MLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---T 1891
V I + D N++ PV +SE++ + + V V A+D D+G + + + +
Sbjct: 1140 AKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPP 1199
Query: 1892 AGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN 1931
+ F + TG++ R +K + D+
Sbjct: 1200 IKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDD 1239
Score = 288 bits (737), Expect = 6e-77
Identities = 320/1103 (29%), Positives = 487/1103 (44%), Gaps = 112/1103 (10%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 133 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 192
Query: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 193 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252
Query: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 253 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 313 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 371
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 372 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427
Query: 368 PLFIQVVDKD-ENLGLNSMFEVYLVGNNSHHFIISPTSV----QGKADIRIRVAIPLDYE 422
PL I +DKD E++ + V H F+ TSV Q + + P+D E
Sbjct: 428 PLRIVALDKDIEDVPPSG---VPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDRE 484
Query: 423 TVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTV 482
Y F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ +
Sbjct: 485 EQQTYTFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQL 543
Query: 483 LATDNDAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG-- 539
A D D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 544 TAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPP 603
Query: 540 --GEETTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQI 596
+ V I VL N+ + P F + Y + E L+ L+ATD + + I
Sbjct: 604 AERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSI 660
Query: 597 TYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVP 656
TY+I + + +L E G++++ + LD E Y+ ++ G P ST
Sbjct: 661 TYAIENGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTAT 714
Query: 657 VTIEVFDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL 713
V I V D NDN P F Y +SVVE A A V + ATD D GQ + YSL
Sbjct: 715 VNIVVTDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSL 768
Query: 714 EG-STQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIN 772
+ FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+
Sbjct: 769 GNFNNLFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDID 825
Query: 773 DNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTT 830
DN P + ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ T
Sbjct: 826 DNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFT 883
Query: 831 GKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF 890
G++ + LD E EA + + PP ATV V + D+ND P F
Sbjct: 884 GELSLLRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVF 938
Query: 891 QNLPFVAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSG 945
+ V G I V A D D GL V YR + P F + SG
Sbjct: 939 SKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSG 998
Query: 946 VVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVS 1005
V+T L+ E ++L VVA D G P SS++T+ I VL E P F Y
Sbjct: 999 RVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPV 1057
Query: 1006 EDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAA 1065
++ + +V + + +N + Y I GN + F + V+ LD ET +
Sbjct: 1058 SELATKGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTS 1114
Query: 1066 YMLILEA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGH 1119
Y+L ++A + N V + + TA V++ + D N++ P+F + Y V ED
Sbjct: 1115 YVLRVQADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFT 1173
Query: 1120 SILQLKATDADEGEFGRVWYRIL 1142
S+L++KATD D G + + YR++
Sbjct: 1174 SVLRVKATDKDTGNYSVMAYRLI 1196
Score = 283 bits (723), Expect = 3e-75
Identities = 341/1265 (26%), Positives = 535/1265 (42%), Gaps = 150/1265 (11%)
Query: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 44 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 99
Query: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 100 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 154
Query: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 155 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 212
Query: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 213 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 268
Query: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
+F +PL Y ++ E N + T + + D + + +
Sbjct: 269 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 328
Query: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 329 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 388
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATD---EDSPPNNQIT 597
+LD N+ P F +Y G + E+ P ++T +R+ A D ED PP+ T
Sbjct: 389 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPT 448
Query: 598 YSIVSASAFGSYFDISLYEGYGV---ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNST 654
Y + G+ +++ +P+D E+ +T + P
Sbjct: 449 KDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP---- 504
Query: 655 VPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE 714
V V I+V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y +
Sbjct: 505 VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEIL 561
Query: 715 GSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDIN 772
Q F IN +G IT ++ Y L V+A D ++ I TV I +L N
Sbjct: 562 VGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPN 621
Query: 773 DNHPT-WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNST 829
+ P + Y + + E + + + A D E ++ Y+I+ P + ++L+ T
Sbjct: 622 NQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSET 678
Query: 830 TGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPT 889
TG I T LDRE+ D R I++ GRP TS+ATV + + D+NDN P
Sbjct: 679 TG-ILTLGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPV 728
Query: 890 FQN-LPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVV 948
F LP V+E A + QV A D D G+NG V Y + G F I +S+G +
Sbjct: 729 FDPYLPRNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIY 784
Query: 949 TTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDV 1008
T +L+RE Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++
Sbjct: 785 TAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 844
Query: 1009 PREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TA 1064
P ++ + D D+G N +SY I V F++ + + LD E A
Sbjct: 845 PAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 902
Query: 1065 AYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
+ ++EA D G G ATV V V D+ND P+F + Y+ V D +G I +
Sbjct: 903 SITFLVEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 960
Query: 1125 KATDADEGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVE 1179
A DAD RV YR + + F + +G ++ L+ E + L+V
Sbjct: 961 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVV 1019
Query: 1180 AYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSG 1239
A++ M SS V + V E P FTQ++Y + E A GT V V+ A +
Sbjct: 1020 AFDDGEPVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS 1078
Query: 1240 DGGLVNYRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPP 1291
+ Y I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 1079 ----IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVP 1134
Query: 1292 FNQGFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYR 1349
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1135 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYR 1194
Query: 1350 FNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITV 1408
+ K F ++ TG+I L + ++ V+A DD G + V ++V
Sbjct: 1195 LIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSV 1254
Query: 1409 LDEND 1413
+++ D
Sbjct: 1255 VNQLD 1259
Score = 281 bits (718), Expect = 1e-74
Identities = 346/1343 (25%), Positives = 586/1343 (43%), Gaps = 160/1343 (11%)
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
I ++ L+G F ++ T +++ V D F ++ +
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 374
Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++ A
Sbjct: 375 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
Query: 2095 DED------SGLNGELVYRIEAGAQDRFLIHLVT--GVIRVGNAT--IDREEQESYRLTV 2144
D+D SG+ + + D + VT G+ R +DREEQ++Y ++
Sbjct: 435 DKDIEDVPPSGVPTKDP-ELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSI 493
Query: 2145 VATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD-- 2202
A D V S IV I + D ND+ P F V V PG + +TA+D D
Sbjct: 494 TAFDG--VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEG 551
Query: 2203 LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVID 2262
N ++ Y I LV Q D F +N TG + + + + TY +T+ D
Sbjct: 552 SNGEITYEI-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAAD 599
Query: 2263 NASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVD 2322
NA ER S+ + + VL N+ +P P + Y +E I E G L+ + A D
Sbjct: 600 NAPPA-ERRNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATD 654
Query: 2323 PDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPR 2382
+ +TY + + P L +++ G + + +D E + ASD G P
Sbjct: 655 RE---GDSITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDG 709
Query: 2383 AAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLG 2442
+ V + + D+NDN P+FD + + + V ATD D+G + YSLG
Sbjct: 710 TSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLG 769
Query: 2443 DGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDV 2502
+ + F I + G IY L+RE +D+Y L +A D A + R +++ + I+VLD+
Sbjct: 770 NFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDI 824
Query: 2503 NDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMD 2561
+D P F+ ++ V EN PAGT+++ + A D D G N ++Y + P V+ F +
Sbjct: 825 DDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPF 882
Query: 2562 SGLVTTQRPLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFV 2612
+G ++ R L YE F + V A D G PP G + V V D+ND PVF
Sbjct: 883 TGELSLLRSLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFS 939
Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPIS 2670
+ + + + + + VYA D D GL + VRY F ++ S
Sbjct: 940 KRIYKGM--VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS 997
Query: 2671 GLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSP 2730
G + T L+ E ++ L++VA D G+PV + + L P F +
Sbjct: 998 GRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE----- 1050
Query: 2731 QYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLR 2789
+Y+ V E + +GT+VG ++ A N + Y I +GNEE F + G + V
Sbjct: 1051 EYRPPPVSELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNG 1105
Query: 2790 DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKA 2849
LD E + V+A S L + + +V + ++D N+ PP F K
Sbjct: 1106 PLDYETRTSYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKK 1159
Query: 2850 EYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGS 2909
Y GV+ DA++ + +++V A D D GN YS++A +R + ++ + F + +
Sbjct: 1160 FYIGGVSEDARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVET 1211
Query: 2910 MDGILRTFDLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEI 2964
G+++T LF YF ++A D L+G D + + L D +V IV N
Sbjct: 1212 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVP 1268
Query: 2965 PDRVRGFEEEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRD 3017
P V E+ +L I GA +V + + H D ++ + +L ++ ++
Sbjct: 1269 PTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQ 1328
Query: 3018 TNRILDVDRVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMA 3068
TNR +D + + + +D + F+ Y +L+++ +V + + + + A
Sbjct: 1329 TNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGA 1388
Query: 3069 IIVLAILLFLA---AMLFVLMNW 3088
++ LA ++ L A+L VL+++
Sbjct: 1389 LLALAFIIILCCIPAILVVLVSY 1411
Score = 273 bits (699), Expect = 2e-72
Identities = 320/1184 (27%), Positives = 520/1184 (43%), Gaps = 149/1184 (12%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 195
Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 196 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
L V +LD +D P+ P Y ++ E + ++
Sbjct: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 369
Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 370 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
Query: 1656 TIQALDLD---EGPNGTVT----YAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHG 1705
I ALD D P+G T + + + F + + G+ +T + +D E
Sbjct: 430 RIVALDKDIEDVPPSGVPTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQ 487
Query: 1706 RYTLIVTATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRV 1763
YT +TA D + + V+VN+ D NDN PTFP + T+ +PG V
Sbjct: 488 TYTFSITAFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSV 540
Query: 1764 WTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICA 1823
A D D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A
Sbjct: 541 IQLTAVDADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQA 597
Query: 1824 RDRGMPP--LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADS 1880
D P +S V I VL N+ P L ++ ISE V + + ++ A+D +
Sbjct: 598 ADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG 657
Query: 1881 GCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIAR 1939
+T+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A
Sbjct: 658 DS---ITYAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTAT 714
Query: 1940 RDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVT 1999
+ I ++D NDN P+F + + A + G + A D D I V
Sbjct: 715 VN-----IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVH 765
Query: 2000 YQLLGAQSGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLI 2057
Y L G + LF I S+ + T V ++RE EL+++A D + +ST L I
Sbjct: 766 YSL-GNFNNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAI 819
Query: 2058 TILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL 2117
+LD +DN P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F
Sbjct: 820 KVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFF 877
Query: 2118 -IHLVTG---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRP 2172
+H TG ++R + +++ S V A D GT+P G A VT+++ D+ND P
Sbjct: 878 ALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPP 936
Query: 2173 EFLNPIQTVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQE 2228
F I V A GT I + A D D ++ Y + DD P
Sbjct: 937 VFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPA 988
Query: 2229 DAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVND 2288
F V ++G V+ + +N E +++ + D+ V ++ TV +L ++
Sbjct: 989 SIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHP 1041
Query: 2289 NT-PQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLE 2347
P+F Y + E AT GT + ++A +N + Y+++ +
Sbjct: 1042 GEIPRFTQE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGIN 1095
Query: 2348 DSSAGKVIANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNP 2400
+ + G + N +DYE V + V ++ P ++ VY+EI D N++ P
Sbjct: 1096 NIT-GVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1154
Query: 2401 IFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTG 2455
+F + Y V ED + T +L V ATD D+GN++++ Y L +G+ F + TG
Sbjct: 1155 VFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTG 1214
Query: 2456 DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
I ++ ++ +A D+ G S + + V VV Q+
Sbjct: 1215 LIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1258
Score = 267 bits (683), Expect = 1e-70
Identities = 332/1252 (26%), Positives = 532/1252 (42%), Gaps = 159/1252 (12%)
Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 106 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 162
Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 163 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222
Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 223 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282
Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
+Y+AAI E L IV +ID I Y T
Sbjct: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342
Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
Query: 1421 TSDSAVSIPEDCPVGQRVAT----------------VKAWDPDAGSNGQVVFSLASGNIA 1464
S I E PVG ++ ++ P L +
Sbjct: 403 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPELHLFLNDYT 461
Query: 1465 GAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNP 1524
F + T + + + +P+DREE Y + A D + I+ + ++D NDN
Sbjct: 462 SVFTVTQTGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNT 518
Query: 1525 PVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE 1584
P Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G
Sbjct: 519 PTFPE-ISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGL 576
Query: 1585 IATRPAPPDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEV 1641
I P ++ Y L D P ++ VY+ ++ N+ +P F Q Y +
Sbjct: 577 ITIAPGVEMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 635
Query: 1642 LLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYE 1701
+ E + L+ +QA D + ++TYAI G+ F + G++T K LD E
Sbjct: 636 EISEAM-RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE 691
Query: 1702 ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGP 1761
S RY LI+TA+D P TST TV + V D+NDN P F V E +
Sbjct: 692 -STDRYILIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANA 746
Query: 1762 RVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTI 1821
V A D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L +
Sbjct: 747 FVGQVKATDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVV 801
Query: 1822 CARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSG 1881
A D + P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G
Sbjct: 802 VATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLG 861
Query: 1882 CNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------P 1935
N +++ I + + F ++ TG +++ R LD E P+ + +I+ + P
Sbjct: 862 AN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPP 919
Query: 1936 RIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIY 1995
IA + + + D ND P+F+K Y+ V ++ GTP+T + A DAD
Sbjct: 920 GIA-----TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGL 970
Query: 1996 AV--VTYQLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG-- 2047
V Y++ Q + +F++ +G V R V ++ E + I +L+++A D G
Sbjct: 971 PASRVRYRVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEP 1026
Query: 2048 LLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGE 2103
+++S+A + I +L + P F+ E PP S L T + +N
Sbjct: 1027 VMSSSATVKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQS 1078
Query: 2104 LVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLS 2155
+VY I +G +D F I+ +TGVI V N +D E + SY L V A V S
Sbjct: 1079 IVYSIVSGNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKS 1137
Query: 2156 GTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVG 2213
TA V I I D N+ P F V E A T + + A D D + Y ++
Sbjct: 1138 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLII 1197
Query: 2214 IVAKDDTDRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNAS 2265
K+ ++ F V TG + M +S +++AT + + A
Sbjct: 1198 PPIKEG--------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKAD 1249
Query: 2266 DLPERSVSVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
L VSV N + V V +V + K +T ++R ++ PG ++
Sbjct: 1250 VL----VSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1297
Score = 220 bits (561), Expect = 2e-56
Identities = 254/924 (27%), Positives = 404/924 (43%), Gaps = 105/924 (11%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD-----------NDPL 65
N+ P+FT + Y+L E PVG++++ +++A D D DP
Sbjct: 395 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDVPPSGVPTKDPE 452
Query: 66 VFGVSGEEASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQ 121
+ + S F + T + L QP+DRE + +T FS++ GV + VNIQ
Sbjct: 453 LHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQ 510
Query: 122 VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAI 180
V D NDN PTF Y V + + G + + A D D G+ G + Y +Q F I
Sbjct: 511 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 570
Query: 181 DSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIF 236
+ G++T+ ++ + Y LTV A D P ++ + +V P F
Sbjct: 571 NKTTGLITIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRF 628
Query: 237 INLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLN 296
L YS I E G + + A D++ I Y I +G+ +F L +G+LTL
Sbjct: 629 PQLMYSLEISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLG 685
Query: 297 GLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSV 355
LDRE+ + +IL + + D P D T T T NI+V D+NDNAP F+ ++
Sbjct: 686 KALDRES---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNL 737
Query: 356 AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRV 415
++ E F QV D + G+N Y +GN ++ F I+ I
Sbjct: 738 SVVEEEANAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYT 785
Query: 416 AIPLDYETVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENV 473
A+ L+ E D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+
Sbjct: 786 AVKLNREVRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENL 844
Query: 474 TVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----Q 527
GT++L + A D D G VSY + F+L TG + L+ LDYE
Sbjct: 845 PAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEA 902
Query: 528 RFTLTIIARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRA 585
T + A D G G + V+ D+ND P F K Y G + + T + + A
Sbjct: 903 SITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 962
Query: 586 TDEDSP--PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTV 641
D D P P +++ Y + V S F++ G + V+ L+ E + + L V
Sbjct: 963 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVV 1018
Query: 642 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDR 700
+A D G P ++S+ V I V + P F++ Y V + G V ++A +++
Sbjct: 1019 VAFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQ 1077
Query: 701 SREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGH 755
S Y SI+ E T F IN +G I LD ET++ Y+L V+A V +
Sbjct: 1078 SIVY---SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRV 1133
Query: 756 NQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
K+ A V I + D N++ P ++ Y + E + V V A D D G + Y
Sbjct: 1134 PSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAY 1193
Query: 816 S-IQPPNK----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKA 870
I PP K + + + TG I+T AML + V++ D G+
Sbjct: 1194 RLIIPPIKEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GL 1244
Query: 871 TSSATVFVNLLDLNDNDPTFQNLP 894
+ A V V++++ D N+P
Sbjct: 1245 SGKADVLVSVVNQLDMQVIVSNVP 1268
Score = 218 bits (555), Expect = 8e-56
Identities = 278/1062 (26%), Positives = 454/1062 (42%), Gaps = 142/1062 (13%)
Query: 1896 ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
++ F+N+T R LDR+ P +I V+ N ++ Y + I + D NDN
Sbjct: 96 KQMLFLNST------GRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 148
Query: 1956 HPLFTKSTYQAEVMENSPAGTPL-TVLNGPILALDADQDIYAVVTYQLL-----GAQSGL 2009
P F +Y A V E +P GT + T +G A D D + Y + +
Sbjct: 149 SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDT 208
Query: 2010 FDIN-SSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG-LLNSTAHLLITILDDNDNRP 2067
F+I TG + +R + + + I++ A+++ +T L + +LD +D P
Sbjct: 209 FEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 268
Query: 2068 TFSPATLT-----------------VHLLENCPPGFSVLQVTATDEDSGLNGE-----LV 2105
F P L + E P + A D+D + ++
Sbjct: 269 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 328
Query: 2106 YRIEAGAQDR----FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVT 2161
Y I G + F +H T + + ++R+ + + L + A PL A +
Sbjct: 329 YSILVGTPEDYPRFFHMHPRTAELSL-LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 387
Query: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN---------ITAIDHDLNPKLEYHIV 2212
I I D N+ P F P +LESA G I++ I A+D D+ +
Sbjct: 388 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE---DVPPS 444
Query: 2213 GIVAKDDTDRLVPNQEDAFAVNINTG---SVMVKSPMNRELVATYEVTLSVIDNASDLPE 2269
G+ KD L N + TG + + P++RE TY +++ D +
Sbjct: 445 GVPTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE--- 501
Query: 2270 RSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNG 2329
S P + + V+D NDNTP F Y + PG ++I + AVD D+G NG
Sbjct: 502 ---SEP-VIVNIQVMDANDNTPTFPEISYDVY---VYTDMRPGDSVIQLTAVDADEGSNG 554
Query: 2330 LVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPP--RAAEIP 2387
+TY +L ++ + + G + V+ TV+A+DN P R +
Sbjct: 555 EITYEILVGAQGDFI--INKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICT 612
Query: 2388 VYLEIVDINDNN-PIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDG 2444
VY+E++ N+ + P F Q Y + E + VG ++L + ATD + + I Y++ GD
Sbjct: 613 VYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDP 669
Query: 2445 ESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVND 2504
+ F ++ TTG + + +LDRE D YIL A D D S N I V DVND
Sbjct: 670 QRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN-----IVVTDVND 724
Query: 2505 CRPQFSK--PQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDS 2562
P F P+ + SV E E A V + ATD D G NG++ YSL G F + +
Sbjct: 725 NAPVFDPYLPR-NLSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNG 781
Query: 2563 GLVTT---QRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI 2619
+ T R ++ Y + L VVATDG P T L ++V+D++DN PVF T+
Sbjct: 782 SIYTAVKLNREVRDY--YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-STYTV 838
Query: 2620 LHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRL 2679
L + E +P + + ++ A D D G N + R + FF + P +G + + L
Sbjct: 839 L-VEENLPAGTTILQIEAKDVDLGANVSYRIRSPEVK-----HFFALHPFTGELSLLRSL 892
Query: 2680 DRES----QAVYSLILVASDLGQPVPYETMQP----LQVALEDIDDNEPLFVRPPKGSPQ 2731
D E+ +A + ++ A D+ Y TM P + V ++D++D P+F
Sbjct: 893 DYEAFPDQEASITFLVEAFDI-----YGTMPPGIATVTVIVKDMNDYPPVF-----SKRI 942
Query: 2732 YQLLTVPEHSPRGTLVGNVTGAVDADEG--PNAIVYY---FIAAGNEEKNFHLQPDGCLL 2786
Y+ + P+ + +GT + V A DAD P + V Y + F ++ D +
Sbjct: 943 YKGMVAPD-AVKGTPITTVY-AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV 1000
Query: 2787 VLR-DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPR 2845
+ R +L+ E IF +V A + P S T+ + L L + PR
Sbjct: 1001 ITRVNLNEEPTTIFKLVVVAFDDGE--PVMSSSATVKI---LVLHPGEI---------PR 1046
Query: 2846 FTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILA 2887
FT+ EY ++ ++ V++ A N + YSI++
Sbjct: 1047 FTQEEYRPPPVSELATKGTMVGVISAAA---INQSIVYSIVS 1085
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 301 bits (770), Expect = 9e-81
Identities = 329/1159 (28%), Positives = 527/1159 (45%), Gaps = 143/1159 (12%)
Query: 224 IIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSI 283
I++ D D P F + Y + E +P GTT+ +T SG+ +
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTI-----------------FTGFSGDNGAT 177
Query: 284 FALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDIND 343
D +G + + ++P + LN+ RT TTT + V+D +D
Sbjct: 178 DIDDGPNGQIEYVIQYNPDDP---------DRAQNLNERRT-----TTTTLTVDVLDGDD 223
Query: 344 NAPEF-------NSSE-----YSVAITELAQVGFALPLF----IQVVDKDENLGLNS--- 384
P F N+ + Y AI EL P+ IQ +D+D N+ S
Sbjct: 224 LGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRP 283
Query: 385 -MFEVYLVGNNSHH---FIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDH 440
+ LVG + F + P + + + + P++ + ++D + A +
Sbjct: 284 GILYSILVGTPEDYPRFFHMHPRTAE------LSLLEPVNRDFHQKFDLVIKAEQDNGHP 337
Query: 441 V-GYAKVKITLINENDNRPIFSQPLYNISLYENVTVG---------TSVLTVLATDNDAG 490
+ +A + I +++EN+ P F+ P Y + E+ VG TS L ++A D D
Sbjct: 338 LPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIE 397
Query: 491 TFG--EVSYFFSDDPDRFSLDKD--TGLIMLIARLDYELIQRFTLTIIARDGGGEETTGR 546
E+ F +D F++ + T + L+ +D E Q +T +I A DG E
Sbjct: 398 DTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEPVI 457
Query: 547 VRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAF 606
V I V+D NDN PTF + +Y + + +++L A D D N +ITY I+
Sbjct: 458 VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEIL----V 513
Query: 607 GSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPP--LNSTVPVTIEVFDE 664
G+ D + + G+I+++ + E I LTV A D P NS V IEV
Sbjct: 514 GAQGDFIINKTTGLITIAPGV--EMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPP 571
Query: 665 ND-NPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE-GSTQ--FR 720
N+ +PP F + Y + + E + GA +L L ATD + +SI Y++E G Q F
Sbjct: 572 NNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREG------DSITYAIENGDPQRVFN 625
Query: 721 INARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD 780
++ +G +T LDRE+ YILI+ A DG T ATVNI + D+NDN P +
Sbjct: 626 LSETTGILTLGKALDRESTDRYILIITASDG---RPDGTSTATVNIVVTDVNDNAPVFDP 682
Query: 781 -APYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAM 839
P +++VE ++ V V A DPD G NG + YS+ N + + S G I T
Sbjct: 683 YLPRNLSVVE-EEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSN-GSIYTA-VK 739
Query: 840 LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEV 899
L+RE D +E +VV TD P +T T+ + +LD++DN P F N + V
Sbjct: 740 LNREVRDYYE------LVVVATDGAVHPRHST--LTLAIKVLDIDDNSPVFTNSTYTVLV 791
Query: 900 LEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIA 959
E +PAG +I Q+ A D+D G N VSYR+ + F ++ +G + LD E
Sbjct: 792 EENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFP 849
Query: 960 EYQLRVV----ASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVV 1015
+ + + A D +T+T+ V D+ND P F +Y V+ D + +
Sbjct: 850 DQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPIT 909
Query: 1016 WLNCTDNDV-GLNAE-LSYFITGGNVD---GKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
+ D D GL A + Y + F V V T V L+ E T + L++
Sbjct: 910 TVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 969
Query: 1071 EAIDNG-PVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEAS-VPEDIPEGHSILQLKATD 1128
A D+G PV + +ATV + VL + P F Q Y V E +G + + A
Sbjct: 970 VAFDDGEPV---MSSSATVKILVLHPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAAA 1025
Query: 1129 ADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG-- 1186
++ + Y I+ GN + F I+ G++ PLD E +S+VL V+A + ++
Sbjct: 1026 INQS----IVYSIVSGNEEDTFGINNITGVIYVNG-PLDYETRTSYVLRVQADSLEVVLA 1080
Query: 1187 ----PMRSSV-RVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDG 1241
P +S+ +V + ++D N+ PVF ++ Y G+ E A + TSV+ V+ATD+D+G+
Sbjct: 1081 NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIG-GVSEDARMFTSVLRVKATDKDTGNY 1139
Query: 1242 GLVNYRIL-----SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGF 1296
++ YR++ G EG F ++ TGLI T ++ + V ATD G
Sbjct: 1140 SVMAYRLIIPPIKEGKEG-FVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGK 1198
Query: 1297 CSVYITLLNELDEAVQFSN 1315
V ++++N+LD V SN
Sbjct: 1199 ADVLVSVVNQLDMQVIVSN 1217
Score = 293 bits (750), Expect = 2e-78
Identities = 313/1164 (26%), Positives = 505/1164 (43%), Gaps = 134/1164 (11%)
Query: 833 IRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN 892
+ +T +LDR+ P + IVV V C + V + + D NDN PTF++
Sbjct: 96 LNSTGRVLDRDPPMN-----IHSIVVQV-QCINKKVGTIIYHEVRIVVRDRNDNSPTFKH 149
Query: 893 LPFVAEVLEGIPAGVSIYQVV-----AIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVV 947
+ A V E P G +I+ A D+D+G NG + Y V
Sbjct: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY-------------------V 190
Query: 948 VTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAV-------- 999
+ D +R R +++T+TLT+ VLD +D P F P V
Sbjct: 191 IQYNPDDPDRAQNLNER----------RTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 240
Query: 1000 ----YNVSVSE-DVPREFRVVW----LNCTDNDVGLNAE-----LSYFITGGNVDGK--- 1042
Y ++ E P E + + D D + + Y I G +
Sbjct: 241 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 300
Query: 1043 FSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIF 1102
F + R A + + ++R+ + L+++A + G A + + +LD N+ P F
Sbjct: 301 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDN--GHPLPAFAGLHIEILDENNQSPYF 358
Query: 1103 LQSSYEASVPEDIPEGHSI---------LQLKATDADEGEFGRVWYRILHGNHGNNFRIH 1153
SY+ + E P G +I L++ A D D + + ++ + F +
Sbjct: 359 TMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTV- 417
Query: 1154 VSNGLL--MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSS-VRVIVYVEDINDEAPVFTQ 1210
G+ + +P+DRE ++ + A++ G S V V + V D ND P F +
Sbjct: 418 TQTGITRYLTLLQPVDREEQQTYTFSITAFD---GVQESEPVIVNIQVMDANDNTPTFPE 474
Query: 1211 QQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNY 1270
Y + G SVI + A D D G G + Y IL GA+G F I+++TGLI
Sbjct: 475 ISYDVYVYTDMRP-GDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLITIAPG 533
Query: 1271 LDYETKTSYMMNVSATDQAPPFNQ--GFCSVYITLLNELDEAV-QFSNASYEAAILENLA 1327
++ +Y + V A D APP + C+VYI +L +++ +F Y I E +
Sbjct: 534 VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMR 593
Query: 1328 LGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTL 1387
+G ++ +QA + + ITY A + + +F + TG++T+ +DRE D Y L
Sbjct: 594 VGAVLLNLQATDREG-DSITY---AIENGDPQRVFNLSETTGILTLGKALDRESTDRYIL 649
Query: 1388 TVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPD 1447
+ A DG P ST V I V D NDN+P FD +S+ E+ V VKA DPD
Sbjct: 650 IITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPD 708
Query: 1448 AGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPR 1507
AG NGQV +SL GN F I S G ++ A L+RE D+Y L VVA+D PR
Sbjct: 709 AGINGQVHYSL--GNFNNLFRIT----SNGSIYTAVKLNREVRDYYELVVVATDGAVHPR 762
Query: 1508 KKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYI 1567
L + +LDI+DN PV + Y V V EN+ GT ++Q+ A D D+G N +SY I
Sbjct: 763 HSTLTLAIKVLDIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRI 819
Query: 1568 TEGNKDMAFRMDRISGEIA-----TRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYV 1622
F + +GE++ A PD+E S LV + GT T V V
Sbjct: 820 RSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE-ASITFLVEAFDIYGTMPPGIAT-VTV 877
Query: 1623 TIVDENDNAPMFQQPHYEVLLDEGPDTL-NTSLITIQALDLDEG--PNGTVTYAIVAGNI 1679
+ D ND P+F + Y+ ++ PD + T + T+ A D D P V Y +
Sbjct: 878 IVKDMNDYPPVFSKRIYKGMV--APDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQF 935
Query: 1680 ---VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVND 1736
+ F ++ G + L+ E + ++V D P++S S+ TV + V
Sbjct: 936 PYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS----SSATVKILVLH 991
Query: 1737 INDNVPTFPRDYEGPFEVTE-GQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVIS 1795
+ +P F ++ P V+E G V A + N + YSI+ G+ F I+
Sbjct: 992 PGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEEDTFGIN 1046
Query: 1796 PVEGVLRVRKDVELDRET-----IAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPV 1850
+ GV+ V ++ + T + +L + + +P S+T V I + D N++ PV
Sbjct: 1047 NITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPV 1106
Query: 1851 LLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAGNRERAFFINATTGI 1907
+SE++ + + V V A+D D+G + + + + + F + TG+
Sbjct: 1107 FQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGL 1166
Query: 1908 VTVNRPLDRERIPEYKLTISVKDN 1931
+ R +K + D+
Sbjct: 1167 IKTAMLFHNMRRSYFKFQVIATDD 1190
Score = 283 bits (724), Expect = 2e-75
Identities = 309/1079 (28%), Positives = 479/1079 (44%), Gaps = 108/1079 (10%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
Query: 168 LYSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIIT 227
Y Q + D R + L+ T LTV+ D D P+ +++
Sbjct: 188 EYVIQ----YNPDDPDRA-----QNLNERRTTTTTLTVDVLDGDDLGPMFLPC---VLVP 235
Query: 228 DVQDMDPIF-------INLPYSTNIYEHSPPGTTVRIITAIDQDKG------RPRGIGYT 274
+ +D P+ + P N +PP I AIDQD+ RP GI Y+
Sbjct: 236 NTRDCRPLTYQAAIPELRTPEELNPIIVTPP------IQAIDQDRNIQPPSDRP-GILYS 288
Query: 275 IVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
I+ G ++ LL+ N + F L +K + N P+ A +
Sbjct: 289 ILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGL---- 344
Query: 335 NILVIDINDNAPEFNSSEYSVAITELAQVGFAL--------PLFIQVVDKDENLGLNSMF 386
+I ++D N+ +P F Y I E A VG + PL I +DKD +
Sbjct: 345 HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL 404
Query: 387 EVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKV 446
++L + + F ++ T + + + P+D E Y F + A + V + V
Sbjct: 405 HLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTYTFSITAFDGVQESEPVI-V 458
Query: 447 KITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY-FFSDDPDR 505
I +++ NDN P F + Y++ +Y ++ G SV+ + A D D G+ GE++Y
Sbjct: 459 NIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGD 518
Query: 506 FSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEETTGRVRINVLDVND-NVPT 560
F ++K TGLI + ++ + + + LT+ A D + V I VL N+ + P
Sbjct: 519 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 578
Query: 561 FQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGV 620
F + Y + E L+ L+ATD + + ITY+I + + +L E G+
Sbjct: 579 FPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVF---NLSETTGI 632
Query: 621 ISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYF--- 677
+++ + LD E Y+ ++ G P ST V I V D NDN P F Y
Sbjct: 633 LTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVVTDVNDNAPVFD--PYLPRN 687
Query: 678 VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-STQFRINARSGEITTTSLLDR 736
+SVVE A A V + ATD D GQ + YSL + FRI + +G I T L+R
Sbjct: 688 LSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNNLFRITS-NGSIYTAVKLNR 742
Query: 737 ETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSD 796
E + Y L+V A DG V T T+ I +LDI+DN P + ++ Y + + E P +
Sbjct: 743 EVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 800
Query: 797 VTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMR 854
+ + A D DLG N + Y I+ P F++L+ TG++ + LD E EA +
Sbjct: 801 ILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRS-LDYEAFPDQEASITF 857
Query: 855 KIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVA 914
+ PP ATV V + D+ND P F + V G I V A
Sbjct: 858 LVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYA 913
Query: 915 IDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASD 969
D D GL V YR + P F + SG V+T L+ E ++L VVA D
Sbjct: 914 EDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFD 973
Query: 970 AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAE 1029
G P SS++T+ I VL E P F Y ++ + +V + + +N
Sbjct: 974 DGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELATKGTMVGV---ISAAAINQS 1029
Query: 1030 LSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLILEA------IDNGPVGKRHT 1083
+ Y I GN + F + V+ LD ET +Y+L ++A + N V + +
Sbjct: 1030 IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSK-S 1088
Query: 1084 GTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRIL 1142
TA V++ + D N++ P+F + Y V ED S+L++KATD D G + + YR++
Sbjct: 1089 NTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLI 1147
Score = 278 bits (712), Expect = 5e-74
Identities = 345/1336 (25%), Positives = 580/1336 (43%), Gaps = 160/1336 (11%)
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNI- 1890
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1891 -TAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPE-NPRIARRDYDLLLIF 1948
+ +RA + L+ R LT+ V D + P L +
Sbjct: 193 YNPDDPDRA-------------QNLNERRTTTTTLTVDVLDGDDLGPMF------LPCVL 233
Query: 1949 LSDENDNHPLFTKSTYQAEVME-NSPAGTPLTVLNGPILALDADQDIY------AVVTYQ 2001
+ + D PL TYQA + E +P ++ PI A+D D++I ++
Sbjct: 234 VPNTRDCRPL----TYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSI 289
Query: 2002 LLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGL-LNSTAHLLI 2057
L+G F ++ T +++ V D F ++ +D G L + A L I
Sbjct: 290 LVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQDNGHPLPAFAGLHI 346
Query: 2058 TILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTATDEDSGLNGELVYRI 2108
ILD+N+ P F+ + ++LE+ P G ++ L++ A D+D + +
Sbjct: 347 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 406
Query: 2109 EAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTVPLSGTAIVTILIDD 2166
TG+ R +DREEQ++Y ++ A D V S IV I + D
Sbjct: 407 FLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMD 464
Query: 2167 INDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLV 2224
ND+ P F V V PG + +TA+D D N ++ Y I LV
Sbjct: 465 ANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEI-----------LV 513
Query: 2225 PNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVL 2284
Q D F +N TG + + + + TY +T+ DNA ER S+ + + VL
Sbjct: 514 GAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ERRNSI--CTVYIEVL 569
Query: 2285 DVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYV 2344
N+ +P P + Y +E I E G L+ + A D + +TY + + P
Sbjct: 570 PPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDSITYAIENGDPQRVF 624
Query: 2345 QLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ 2404
L +++ G + + +D E + ASD G P + V + + D+NDN P+FD
Sbjct: 625 NLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDP 682
Query: 2405 PSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLD 2464
+ + + V ATD D+G + YSLG+ + F I + G IY L+
Sbjct: 683 YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAVKLN 741
Query: 2465 REKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPA 2524
RE +D+Y L +A D A + R +++ + I+VLD++D P F+ ++ V EN PA
Sbjct: 742 REVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPA 797
Query: 2525 GTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQRPLQSYEKF------ 2577
GT+++ + A D D G N ++Y + P V+ F + +G ++ R L YE F
Sbjct: 798 GTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD-YEAFPDQEAS 854
Query: 2578 -SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634
+ V A D G PP G + V V D+ND PVF + + + + + +
Sbjct: 855 ITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM--VAPDAVKGTPITT 910
Query: 2635 VYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILV 2692
VYA D D GL + VRY F ++ SG + T L+ E ++ L++V
Sbjct: 911 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 970
Query: 2693 ASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTG 2752
A D G+PV + + L P F + +Y+ V E + +GT+VG ++
Sbjct: 971 AFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVSELATKGTMVGVISA 1023
Query: 2753 AVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSW 2811
A N + Y I +GNEE F + G + V LD E + V+A S
Sbjct: 1024 AAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVV 1078
Query: 2812 TPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLAL 2871
L + + +V + ++D N+ PP F K Y GV+ DA++ + +++V A
Sbjct: 1079 LA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKAT 1132
Query: 2872 DADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVD 2931
D D GN YS++A +R + ++ + F + + G+++T LF YF
Sbjct: 1133 DKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQ 1184
Query: 2932 IVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLL-----SN 2981
++A D L+G D + + L D +V IV N P V E+ +L
Sbjct: 1185 VIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKIEDLTEILDRYVQEQ 1241
Query: 2982 ITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLR 3039
I GA +V + + H D ++ + +L ++ ++ TNR +D + + + +D +
Sbjct: 1242 IPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDIN 1301
Query: 3040 NLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILLFLA---AMLFVLMN 3087
F+ Y +L+++ +V + + + + A++ LA ++ L A+L VL++
Sbjct: 1302 KDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVS 1361
Query: 3088 WYYRTVHKRKLKAIVA 3103
+ R K I A
Sbjct: 1362 YRQRQAECTKTARIQA 1377
Score = 276 bits (705), Expect = 3e-73
Identities = 334/1235 (27%), Positives = 520/1235 (42%), Gaps = 134/1235 (10%)
Query: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 39 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94
Query: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 95 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149
Query: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQ 406
Y + EL VG + D D+ G N E Y++ N P Q
Sbjct: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIE-YVIQYNPD----DPDRAQ 202
Query: 407 GKADIRIRVAIPLDYETVDRYDFDLFANESVPDHVGYAKVKITLINENDNRPIFSQ---P 463
+ R TVD D D +P + + N D RP+ Q P
Sbjct: 203 NLNERRTTTTTL----TVDVLDGDDLGPMFLPC--------VLVPNTRDCRPLTYQAAIP 250
Query: 464 LYNISLYENVTVGTSVLTVLATDNDAGTFGE---VSYFF-----SDDPDRFSLDKDTGLI 515
N + T + + D + + + Y D P F + T +
Sbjct: 251 ELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAEL 310
Query: 516 MLIARLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALREN 573
L+ ++ + Q+F L I A G + I +LD N+ P F +Y G + E+
Sbjct: 311 SLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILES 370
Query: 574 EP---------SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVS 624
P ++T +R+ A D+D + + + S F ++ +++
Sbjct: 371 APVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLL 429
Query: 625 RPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI 684
+P+D E+ +T + P V V I+V D NDN PTF + +Y V V ++
Sbjct: 430 QPVDREEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEISYDVYVYTDM 485
Query: 685 MAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEY 742
G +V+ L A D D E I Y + Q F IN +G IT ++ Y
Sbjct: 486 RPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTY 542
Query: 743 ILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT-WKDAPYYINLVEMTPPDSDVTTVV 801
L V+A D ++ I TV I +L N+ P + Y + + E + + +
Sbjct: 543 ALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQ 602
Query: 802 AVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVS 859
A D E ++ Y+I+ P + ++L+ TTG I T LDRE+ D R I++
Sbjct: 603 ATDR---EGDSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTD-------RYILII 651
Query: 860 VTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LPFVAEVLEGIPAGVSIYQVVAIDLD 918
GRP TS+ATV + + D+NDN P F LP V+E A + QV A D D
Sbjct: 652 TASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPD 708
Query: 919 EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSST 978
G+NG V Y + G F I +S+G + T +L+RE Y+L VVA+D + ST
Sbjct: 709 AGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST 765
Query: 979 STLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGN 1038
TL I VLD++D +P F + Y V V E++P ++ + D D+G N +SY I
Sbjct: 766 LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPE 823
Query: 1039 VDGKFSVGYRDAVVRTVVGLDRET----TAAYMLILEAIDNGPVGKRHTGTATVFVTVLD 1094
V F++ + + LD E A+ ++EA D G G ATV V V D
Sbjct: 824 VKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKD 881
Query: 1095 VNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF--GRVWYR---ILHGNHGNN 1149
+ND P+F + Y+ V D +G I + A DAD RV YR + +
Sbjct: 882 MNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASI 941
Query: 1150 FRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFT 1209
F + +G ++ L+ E + L+V A++ M SS V + V E P FT
Sbjct: 942 FEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH-PGEIPRFT 999
Query: 1210 QQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITV 1268
Q++Y + E A GT V V+ A + + Y I+SG E F I+ TG+I
Sbjct: 1000 QEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVN 1055
Query: 1269 NYLDYETKTSYMMNVSA-------TDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAA 1321
LDYET+TSY++ V A + P VYI + +E + F Y
Sbjct: 1056 GPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGG 1115
Query: 1322 ILENLALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDR 1379
+ E+ + T ++RV+A D N + + YR + K F ++ TG+I L
Sbjct: 1116 VSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHN 1175
Query: 1380 EKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
+ ++ V+A DD G + V ++V+++ D
Sbjct: 1176 MRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1210
Score = 261 bits (666), Expect = 1e-68
Identities = 307/1154 (26%), Positives = 501/1154 (43%), Gaps = 133/1154 (11%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1458 LA-SGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVT 1516
+ + + + + + LD ++L L V R + +
Sbjct: 191 IQYNPDDPDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIP 250
Query: 1517 ILDIND--NPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSV-----LSYYITE 1569
L + NP ++ P ++A D+D I + Y I
Sbjct: 251 ELRTPEELNPIIVTPP-------------------IQAIDQDRNIQPPSDRPGILYSILV 291
Query: 1570 GNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVD 1626
G + F M + E++ P +R+ + LV E + L A +++ I+D
Sbjct: 292 GTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILD 350
Query: 1627 ENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLITIQALDLDEGPNGTVTYAIVAGN 1678
EN+ +P F P Y+ +L+ P D+LN TS + I ALD D + +
Sbjct: 351 ENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 410
Query: 1679 IVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVN 1735
+ F + + G+ +T + +D E YT +TA D + + V+VN+
Sbjct: 411 YTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSITAFDG-------VQESEPVIVNIQ 461
Query: 1736 --DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFV 1793
D NDN PTFP + T+ +PG V A D D G NG++ Y I+ G G+F+
Sbjct: 462 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ-GDFI 520
Query: 1794 ISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP--LSSTMLVGIRVLDINDNDPVL 1851
I+ G++ + VE+ Y LT+ A D P +S V I VL N+ P
Sbjct: 521 INKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 578
Query: 1852 L-NLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTV 1910
L ++ ISE V + + ++ A+D + +T+ I G+ +R F ++ TTGI+T+
Sbjct: 579 FPQLMYSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTL 635
Query: 1911 NRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVM 1969
+ LDRE Y L I+ D P+ A + I ++D NDN P+F + +
Sbjct: 636 GKALDRESTDRYILIITASDGRPDGTSTATVN-----IVVTDVNDNAPVFDPYLPRNLSV 690
Query: 1970 ENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDR 2029
A + G + A D D I V Y L G + LF I S+ + T V ++R
Sbjct: 691 VEEEANAFV----GQVKATDPDAGINGQVHYSL-GNFNNLFRITSNGSIYTA---VKLNR 742
Query: 2030 EAFSPPILELLLLAED--IGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFS 2087
E EL+++A D + +ST L I +LD +DN P F+ +T TV + EN P G +
Sbjct: 743 EVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 800
Query: 2088 VLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG---VIRVGNATIDREEQESYRLT 2143
+LQ+ A D D G N + YRI + F +H TG ++R + +++ S
Sbjct: 801 ILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 858
Query: 2144 VVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD 2202
V A D GT+P G A VT+++ D+ND P F I V A GT I + A D D
Sbjct: 859 VEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 917
Query: 2203 LN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTL 2258
++ Y + DD P F V ++G V+ + +N E +++ +
Sbjct: 918 PPGLPASRVRYRV------DDVQ--FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVV 969
Query: 2259 SVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFKPFGITYYMERILEGATPGTTLIA 2317
D+ V ++ TV +L ++ P+F Y + E AT GT +
Sbjct: 970 VAFDDGEP-------VMSSSATVKILVLHPGEIPRFTQE--EYRPPPVSELATKGTMVGV 1020
Query: 2318 VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYE-------EVHWLNF 2370
++A +N + Y+++ + + + G + N +DYE V +
Sbjct: 1021 ISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVIYVNGPLDYETRTSYVLRVQADSL 1075
Query: 2371 TVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDAD 2430
V ++ P ++ VY+EI D N++ P+F + Y V ED + T +L V ATD D
Sbjct: 1076 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKD 1135
Query: 2431 SGNFALIEYSL-----GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVA 2485
+GN++++ Y L +G+ F + TG I ++ ++ +A D+ G
Sbjct: 1136 TGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGL 1195
Query: 2486 SNRRENSVQVVIQV 2499
S + + V VV Q+
Sbjct: 1196 SGKADVLVSVVNQL 1209
Score = 252 bits (644), Expect = 4e-66
Identities = 297/1095 (27%), Positives = 471/1095 (43%), Gaps = 141/1095 (12%)
Query: 1730 VLVNVNDINDNVPTFPRD--YEGPFEVTEGQPGPRVWTFLAHDR-----DSGPNGQVEYS 1782
V + V D NDN PTF + Y E+T G ++T + D D GPNGQ+EY
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTP--VGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1783 IM--DGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIR 1840
I DP + L+ LT+ D L L +
Sbjct: 191 IQYNPDDP---------------DRAQNLNERRTTTTTLTVDVLDGD--DLGPMFLPCVL 233
Query: 1841 VLDINDNDPVLLN--LPMNITISENSPVSSFVAHVLASDADSGCNAR-----LTFNITAG 1893
V + D P+ +P T E +P+ + A D D + ++I G
Sbjct: 234 VPNTRDCRPLTYQAAIPELRTPEELNPII-VTPPIQAIDQDRNIQPPSDRPGILYSILVG 292
Query: 1894 NRE---RAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLS 1950
E R F ++ T +++ P++R+ ++ L I + + +P A + L I +
Sbjct: 293 TPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPA---FAGLHIEIL 349
Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTV---LNGPILALDADQDIYAVVTYQLLGAQS 2007
DEN+ P FT +YQ ++E++P G ++ L P+ + D+DI +L
Sbjct: 350 DENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPEL----- 404
Query: 2008 GLFDINSSTGVVTV-RSGVI--------IDREAFSPPILELLLLAEDIGLLNSTAHLLIT 2058
LF +N T V TV ++G+ +DRE + A D + + I
Sbjct: 405 HLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE--EQQTYTFSITAFDGVQESEPVIVNIQ 461
Query: 2059 ILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLI 2118
++D NDN PTF + V++ + PG SV+Q+TA D D G NGE+ Y I GAQ F+I
Sbjct: 462 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFII 521
Query: 2119 HLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDI---NDSRPEFL 2175
+ TG+I + ++ +Y LTV A D +I T+ I+ + N S P F
Sbjct: 522 NKTTGLITIAPG-VEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFP 580
Query: 2176 NPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
+ ++ + E+ G V+ N+ A D + + I + D R+ F ++
Sbjct: 581 QLMYSLEISEAMRVGAVLLNLQATDREGD-----SITYAIENGDPQRV-------FNLSE 628
Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKP 2295
TG + + ++RE Y + ++ D D A + + V DVNDN P F P
Sbjct: 629 TTGILTLGKALDRESTDRYILIITASDGRPD------GTSTATVNIVVTDVNDNAPVFDP 682
Query: 2296 FGITYYMERILEGATPGTTLIA--VAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGK 2353
Y+ R L V A DPD G+NG V Y+L + + S
Sbjct: 683 -----YLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTA 737
Query: 2354 VIANRTV-DYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVF 2412
V NR V DY E+ V A+D PR + + + ++++DI+DN+P+F +Y V
Sbjct: 738 VKLNREVRDYYEL-----VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVE 792
Query: 2413 EDVPVGTIILTVTATDADSGNFALIEYSLGDGESK--FAINPTTGDIYVLSSLDREKKDH 2470
E++P GT IL + A D D G A + Y + E K FA++P TG++ +L SLD E
Sbjct: 793 ENLPAGTTILQIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPD 850
Query: 2471 YILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVIT 2530
+ D+ V + V D+ND P FSK + V + GT + T
Sbjct: 851 QEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT 910
Query: 2531 MMATDQDEG--PNGELTYSLEGP----GVEAFHVDMDSGLVTTQRPLQSYEK--FSLTVV 2582
+ A D D P + Y ++ F V+ DSG V T+ L F L VV
Sbjct: 911 VYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVV 970
Query: 2583 ATDGGEPPLWGTTMLLVEVIDVNDNRPVFV----RPPNGTILHIREEIPLRSNVYEVYAT 2638
A D GEP + + + + V+ + P F RPP + E+ + + V +
Sbjct: 971 AFDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVS------ELATKGTMVGVISA 1023
Query: 2639 DKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY-------SLIL 2691
+N ++ YS + +GN + + F I+ I+G+I LD E++ Y SL +
Sbjct: 1024 ---AAINQSIVYSIV--SGNEE-DTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEV 1077
Query: 2692 VASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVT 2751
V ++L P T +V +E D+N PP ++ + V E + T V V
Sbjct: 1078 VLANLRVPSKSNT---AKVYIEIQDENN----HPPVFQKKFYIGGVSEDARMFTSVLRVK 1130
Query: 2752 GAVDADEGPNAIVYY 2766
A D D G +++ Y
Sbjct: 1131 -ATDKDTGNYSVMAY 1144
Score = 223 bits (568), Expect = 2e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 353 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 410
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 411 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 468
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 469 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 528
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 529 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 587 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 643
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 644 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 695
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 696 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 743
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 744 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 802
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 803 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 860
Query: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 861 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 920
Query: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 921 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 976
Query: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 977 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1032
Query: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 1033 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1091
Query: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 1092 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1151
Query: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 1152 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1202
Query: 878 VNLLDLNDNDPTFQNLP 894
V++++ D N+P
Sbjct: 1203 VSVVNQLDMQVIVSNVP 1219
Score = 213 bits (542), Expect = 3e-54
Identities = 272/1042 (26%), Positives = 440/1042 (42%), Gaps = 146/1042 (14%)
Query: 1896 ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
++ F+N+T R LDR+ P +I V+ N ++ Y + I + D NDN
Sbjct: 91 KQMLFLNST------GRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
Query: 1956 HPLFTKSTYQAEVMENSPAGTPL-TVLNGPILALDADQDIYAVVTYQLL---GAQSGLFD 2011
P F +Y A V E +P GT + T +G A D D + Y + +
Sbjct: 144 SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPDRAQN 203
Query: 2012 INSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRP-TFS 2070
+N T + ++D + P L +L + + D RP T+
Sbjct: 204 LNERRTTTTTLTVDVLDGDDLGPMFLPCVL-----------------VPNTRDCRPLTYQ 246
Query: 2071 PATLTVHLLENCPPGFSVLQVTATDEDSGLNGE-----LVYRIEAGAQDR----FLIHLV 2121
A + E P + A D+D + ++Y I G + F +H
Sbjct: 247 AAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPR 306
Query: 2122 TGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTV 2181
T + + ++R+ + + L + A PL A + I I D N+ P F P
Sbjct: 307 TAELSL-LEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQG 365
Query: 2182 SVLESAEPGTVIAN---------ITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFA 2232
+LESA G I++ I A+D D+ KD L N +
Sbjct: 366 YILESAPVGATISDSLNLTSPLRIVALDKDIED----------TKDPELHLFLNDYTSVF 415
Query: 2233 VNINTG---SVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDN 2289
TG + + P++RE TY +++ D + S P + + V+D NDN
Sbjct: 416 TVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQE------SEP-VIVNIQVMDANDN 468
Query: 2290 TPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDS 2349
TP F Y + PG ++I + AVD D+G NG +TY +L ++ +
Sbjct: 469 TPTFPEISYDVY---VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFI--INK 523
Query: 2350 SAGKVIANRTVDYEEVHWLNFTVRASDNGSPP--RAAEIPVYLEIVDINDNN-PIFDQPS 2406
+ G + V+ TV+A+DN P R + VY+E++ N+ + P F Q
Sbjct: 524 TTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLM 583
Query: 2407 YQEAVFEDVPVGTIILTVTATDADSGNFALIEYSL--GDGESKFAINPTTGDIYVLSSLD 2464
Y + E + VG ++L + ATD + + I Y++ GD + F ++ TTG + + +LD
Sbjct: 584 YSLEISEAMRVGAVLLNLQATDREGDS---ITYAIENGDPQRVFNLSETTGILTLGKALD 640
Query: 2465 REKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSK--PQFSTSVYENE 2522
RE D YIL A D D S N I V DVND P F P+ + SV E E
Sbjct: 641 RESTDRYILIITASDGRPDGTSTATVN-----IVVTDVNDNAPVFDPYLPR-NLSVVEEE 694
Query: 2523 PAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTT---QRPLQSYEKFSL 2579
A V + ATD D G NG++ YSL G F + + + T R ++ Y + L
Sbjct: 695 -ANAFVGQVKATDPDAGINGQVHYSL-GNFNNLFRITSNGSIYTAVKLNREVRDY--YEL 750
Query: 2580 TVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATD 2639
VVATDG P T L ++V+D++DN PVF T+L + E +P + + ++ A D
Sbjct: 751 VVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTN-STYTVL-VEENLPAGTTILQIEAKD 808
Query: 2640 KDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRES----QAVYSLILVASD 2695
D G N + R + FF + P +G + + LD E+ +A + ++ A D
Sbjct: 809 VDLGANVSYRIRSPEVK-----HFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD 863
Query: 2696 LGQPVPYETMQP----LQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVT 2751
+ Y TM P + V ++D++D P+F Y+ + P+ + +GT + V
Sbjct: 864 I-----YGTMPPGIATVTVIVKDMNDYPPVF-----SKRIYKGMVAPD-AVKGTPITTVY 912
Query: 2752 GAVDADEG--PNAIVYY---FIAAGNEEKNFHLQPDGCLLVLR-DLDREREAIFSFIVKA 2805
A DAD P + V Y + F ++ D ++ R +L+ E IF +V A
Sbjct: 913 -AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVA 971
Query: 2806 SSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSEL 2865
+ P S T+ + L L + PRFT+ EY ++ +
Sbjct: 972 FDDGE--PVMSSSATVKI---LVLHPGEI---------PRFTQEEYRPPPVSELATKGTM 1017
Query: 2866 IQVLALDADIGNNSLVFYSILA 2887
+ V++ A N + YSI++
Sbjct: 1018 VGVISAAA---INQSIVYSIVS 1036
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 290 bits (743), Expect = 1e-77
Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
Query: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 308 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 367 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 478 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
Query: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 537 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 543 TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
+ V I VL N+ + P F + Y + E L+ L+ATD + + ITY+I
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
+ + +L E G++++ + LD E Y+ ++ G P ST V I V
Sbjct: 654 NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707
Query: 662 FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
D NDN P F Y +SVVE A A V + ATD D GQ + YSL +
Sbjct: 708 TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761
Query: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+DN P
Sbjct: 762 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
+ ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ TG++
Sbjct: 819 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
+ LD E EA + + PP ATV V + D+ND P F +
Sbjct: 877 LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931
Query: 896 VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
V G I V A D D GL V YR + P F + SG V+T
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
L+ E ++L VVA D G P SS++T+ I VL E P F Y ++
Sbjct: 992 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050
Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
+ +V + + +N + Y I GN + F + V+ LD ET +Y+L +
Sbjct: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
+A + N V + + TA V++ + D N++ P+F + Y V ED S+L++
Sbjct: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 1125 KATDADEGEFGRVWYRIL 1142
KATD D G + + YR++
Sbjct: 1167 KATDKDTGNYSVMAYRLI 1184
Score = 284 bits (727), Expect = 9e-76
Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
I ++ L+G F ++ T +++ V D F ++ +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 369
Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++ A
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
D+D + + TG+ R +DREEQ++Y ++ A D V
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 487
Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
S IV I + D ND+ P F V V PG + +TA+D D N ++ Y
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
I LV Q D F +N TG + + + + TY +T+ DNA ER
Sbjct: 548 I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 594
Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
S+ + + VL N+ +P P + Y +E I E G L+ + A D +
Sbjct: 595 RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 647
Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
+TY + + P L +++ G + + +D E + ASD G P + V +
Sbjct: 648 ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705
Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
+ D+NDN P+FD + + + V ATD D+G + YSLG+ + F I
Sbjct: 706 VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 765
Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
+ G IY L+RE +D+Y L +A D A + R +++ + I+VLD++D P F+
Sbjct: 766 T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 820
Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
++ V EN PAGT+++ + A D D G N ++Y + P V+ F + +G ++ R
Sbjct: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 878
Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
L YE F + V A D G PP G + V V D+ND PVF + +
Sbjct: 879 SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 934
Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ + + + VYA D D GL + VRY F ++ SG + T
Sbjct: 935 -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
L+ E ++ L++VA D G+PV + + L P F + +Y+ V
Sbjct: 994 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1046
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
E + +GT+VG ++ A N + Y I +GNEE F + G + V LD E
Sbjct: 1047 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1101
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
+ V+A S L + + +V + ++D N+ PP F K Y GV+
Sbjct: 1102 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1155
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
DA++ + +++V A D D GN YS++A +R + ++ + F + + G+++T
Sbjct: 1156 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1207
Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
LF YF ++A D L+G D + + L D +V IV N P V
Sbjct: 1208 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1264
Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
E+ +L I GA +V + + H D ++ + +L ++ ++ TNR +D +
Sbjct: 1265 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1324
Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
+ + +D + F+ Y +L+++ +V + + + + A++ LA ++
Sbjct: 1325 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1384
Query: 3077 FLA---AMLFVLMNW 3088
L A+L VL+++
Sbjct: 1385 ILCCIPAILVVLVSY 1399
Score = 280 bits (716), Expect = 2e-74
Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)
Query: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 39 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94
Query: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 95 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149
Query: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207
Query: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 208 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263
Query: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
+F +PL Y ++ E N + T + + D + + +
Sbjct: 264 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323
Query: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 324 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
+LD N+ P F +Y G + E+ P ++T +R+ A D+D +
Sbjct: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
Query: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
+ + S F ++ +++ +P+D E+ +T + P V V I+
Sbjct: 444 F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498
Query: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y + Q
Sbjct: 499 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555
Query: 719 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
F IN +G IT ++ Y L V+A D ++ I TV I +L N+ P
Sbjct: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
+ Y + + E + + + A D E ++ Y+I+ P + ++L+ TTG I T
Sbjct: 616 FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
LDRE+ D R I++ GRP TS+ATV + + D+NDN P F LP
Sbjct: 672 LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722
Query: 895 FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
V+E A + QV A D D G+NG V Y + G F I +S+G + T +L+
Sbjct: 723 RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778
Query: 955 RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
RE Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++P +
Sbjct: 779 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838
Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
+ + D D+G N +SY I V F++ + + LD E A+ ++
Sbjct: 839 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
EA D G G ATV V V D+ND P+F + Y+ V D +G I + A DAD
Sbjct: 897 EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
RV YR + + F + +G ++ L+ E + L+V A++
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013
Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
M SS V + V E P FTQ++Y + E A GT V V+ A + +
Sbjct: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068
Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
Y I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
+ K F ++ TG+I L + ++ V+A DD G + V ++V+++ D
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 275 bits (703), Expect = 6e-73
Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 191 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
L V +LD +D P+ P Y ++ E + ++
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364
Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482
Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 483 AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A D P
Sbjct: 536 ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592
Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
+S V I VL N+ P L ++ ISE V + + ++ A+D + +T
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649
Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A +
Sbjct: 650 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704
Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
I ++D NDN P+F + + A + G + A D D I V Y L G
Sbjct: 705 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759
Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
+ LF I S+ + T V ++RE EL+++A D + +ST L I +LD +D
Sbjct: 760 NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
N P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F +H TG
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872
Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
++R + +++ S V A D GT+P G A VT+++ D+ND P F I
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
V A GT I + A D D ++ Y + DD P F V
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983
Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
++G V+ + +N E +++ + D+ V ++ TV +L ++ P+F
Sbjct: 984 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036
Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
Y + E AT GT + ++A +N + Y+++ + + + G +
Sbjct: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089
Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
N +DYE V + V ++ P ++ VY+EI D N++ P+F + Y
Sbjct: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149
Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
V ED + T +L V ATD D+GN++++ Y L +G+ F + TG I
Sbjct: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
++ ++ +A D+ G S + + V VV Q+
Sbjct: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Score = 274 bits (700), Expect = 1e-72
Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)
Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157
Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
+Y+AAI E L IV +ID I Y T
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
S I E PVG ++ + A D D L + F +
Sbjct: 398 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 457 TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512
Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571
Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
++ Y L D P ++ VY+ ++ N+ +P F Q Y + + E
Sbjct: 572 EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629
Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
+ L+ +QA D + ++TYAI G+ F + G++T K LD E S RY
Sbjct: 630 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685
Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
LI+TA+D P TST TV + V D+NDN P F V E + V A
Sbjct: 686 LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741
Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D +
Sbjct: 742 TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796
Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++
Sbjct: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854
Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
I + + F ++ TG +++ R LD E P+ + +I+ + P IA
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
+ + + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y
Sbjct: 911 -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965
Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
++ Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A
Sbjct: 966 RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021
Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
+ I +L + P F+ E PP S L T + +N +VY I +
Sbjct: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073
Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
G +D F I+ +TGVI V N +D E + SY L V A V S TA V I
Sbjct: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
I D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191
Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
++ F V TG + M +S +++AT + + A L V
Sbjct: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240
Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
SV N + V V +V + K +T ++R ++ PG ++
Sbjct: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285
Score = 223 bits (568), Expect = 2e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 390 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 566 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 624 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 681 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 733 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 781 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 840 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
Query: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 958 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013
Query: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069
Query: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239
Query: 878 VNLLDLNDNDPTFQNLP 894
V++++ D N+P
Sbjct: 1240 VSVVNQLDMQVIVSNVP 1256
Score = 89.0 bits (219), Expect = 7e-17
Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)
Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
P+ A+ E+ GTI++ + G IE SL D + + + L+S
Sbjct: 40 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
R L +D P ++ S N++ ++ +V I V D ND P F
Sbjct: 100 GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150
Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
+ +V E P GT++ T ATD D+GPNG++ Y ++ + F + M
Sbjct: 151 SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210
Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
+G + ++ L +K + + + A D + TT L V+V+D +D P+F V
Sbjct: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
PN I +R L + + A D+D + + YS L
Sbjct: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
FF + P + + + ++R+ + L++ A D G P+P L + + D
Sbjct: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388
Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
++ P F P S Q +L E +P G + N+T A+D D
Sbjct: 389 NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442
Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
+ + F + G L +L+ +DRE + ++F + A D V
Sbjct: 443 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487
Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
+ V + + D ND P F + Y V TD + G +IQ+ A+DAD G+N + Y
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2885 IL 2886
IL
Sbjct: 548 IL 549
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 290 bits (743), Expect = 1e-77
Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 106 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 165
Query: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 166 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 225
Query: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 226 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 285
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 286 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 344
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 345 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 400
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 401 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 455
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 456 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 514
Query: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 515 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 574
Query: 543 TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
+ V I VL N+ + P F + Y + E L+ L+ATD + + ITY+I
Sbjct: 575 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 631
Query: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
+ + +L E G++++ + LD E Y+ ++ G P ST V I V
Sbjct: 632 NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 685
Query: 662 FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
D NDN P F Y +SVVE A A V + ATD D GQ + YSL +
Sbjct: 686 TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 739
Query: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+DN P
Sbjct: 740 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 796
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
+ ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ TG++
Sbjct: 797 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 854
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
+ LD E EA + + PP ATV V + D+ND P F +
Sbjct: 855 LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 909
Query: 896 VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
V G I V A D D GL V YR + P F + SG V+T
Sbjct: 910 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 969
Query: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
L+ E ++L VVA D G P SS++T+ I VL E P F Y ++
Sbjct: 970 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1028
Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
+ +V + + +N + Y I GN + F + V+ LD ET +Y+L +
Sbjct: 1029 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1085
Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
+A + N V + + TA V++ + D N++ P+F + Y V ED S+L++
Sbjct: 1086 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
Query: 1125 KATDADEGEFGRVWYRIL 1142
KATD D G + + YR++
Sbjct: 1145 KATDKDTGNYSVMAYRLI 1162
Score = 286 bits (732), Expect = 2e-76
Identities = 346/1350 (25%), Positives = 584/1350 (43%), Gaps = 151/1350 (11%)
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
I ++ L+G F ++ T +++ V D F ++ +
Sbjct: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 347
Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++ A
Sbjct: 348 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
D+D + + TG+ R +DREEQ++Y ++ A D V
Sbjct: 408 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 465
Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
S IV I + D ND+ P F V V PG + +TA+D D N ++ Y
Sbjct: 466 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 525
Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
I LV Q D F +N TG + + + + TY +T+ DNA ER
Sbjct: 526 I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 572
Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
S+ + + VL N+ +P P + Y +E I E G L+ + A D +
Sbjct: 573 RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 625
Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
+TY + + P L +++ G + + +D E + ASD G P + V +
Sbjct: 626 ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 683
Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
+ D+NDN P+FD + + + V ATD D+G + YSLG+ + F I
Sbjct: 684 VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 743
Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
+ G IY L+RE +D+Y L +A D A + R +++ + I+VLD++D P F+
Sbjct: 744 T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 798
Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
++ V EN PAGT+++ + A D D G N ++Y + P V+ F + +G ++ R
Sbjct: 799 NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 856
Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
L YE F + V A D G PP G + V V D+ND PVF + +
Sbjct: 857 SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 912
Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ + + + VYA D D GL + VRY F ++ SG + T
Sbjct: 913 -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 971
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
L+ E ++ L++VA D G+PV + + L P F + +Y+ V
Sbjct: 972 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1024
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
E + +GT+VG ++ A N + Y I +GNEE F + G + V LD E
Sbjct: 1025 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1079
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
+ V+A S L + + +V + ++D N+ PP F K Y GV+
Sbjct: 1080 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1133
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
DA++ + +++V A D D GN YS++A +R + ++ + F + + G+++T
Sbjct: 1134 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1185
Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
LF YF ++A D L+G D + + L D +V IV N P V
Sbjct: 1186 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1242
Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
E+ +L I GA +V + + H D ++ + +L ++ ++ TNR +D +
Sbjct: 1243 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1302
Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
+ + +D + F+ Y +L+++ +V + + + + A++ LA ++
Sbjct: 1303 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1362
Query: 3077 FLA---AMLFVLMNWYYRTVHKRKLKAIVA 3103
L A+L VL+++ R K I A
Sbjct: 1363 ILCCIPAILVVLVSYRQRQAECTKTARIQA 1392
Score = 279 bits (714), Expect = 3e-74
Identities = 330/1231 (26%), Positives = 525/1231 (42%), Gaps = 128/1231 (10%)
Query: 265 KGRPRGIGYTI---VSGNTNSIFALDYISGVLTLNG---LLDRENPLYSHGFILTVKGTE 318
KG G TI + N + +D + +L LN +LDR+ P+ H ++ V+
Sbjct: 41 KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCIN 100
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQ----VV 374
+ I+V D NDN+P F Y + EL VG +
Sbjct: 101 KK-----VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 155
Query: 375 DKDENLGLNSMFEVYLVGN----NSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD 430
D D+ G N E + N S+ P + G +R R L+YE RY
Sbjct: 156 DIDD--GPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKR----LNYEDKTRYFVI 209
Query: 431 LFANESVPD----HVGYAKVKITLINENDNRPIF-----------SQPL-YNISLYE--- 471
+ AN+ + + + +++ +D P+F +PL Y ++ E
Sbjct: 210 IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRT 269
Query: 472 ----NVTVGTSVLTVLATDNDAGTFGE---VSYFF-----SDDPDRFSLDKDTGLIMLIA 519
N + T + + D + + + Y D P F + T + L+
Sbjct: 270 PEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE 329
Query: 520 RLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEP-- 575
++ + Q+F L I A G + I +LD N+ P F +Y G + E+ P
Sbjct: 330 PVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVG 389
Query: 576 -------SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLD 628
++T +R+ A D+D + + + S F ++ +++ +P+D
Sbjct: 390 ATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVD 448
Query: 629 YEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGA 688
E+ +T + P V V I+V D NDN PTF + +Y V V ++ G
Sbjct: 449 REEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 504
Query: 689 TVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIV 746
+V+ L A D D E I Y + Q F IN +G IT ++ Y L V
Sbjct: 505 SVIQLTAVDAD---EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTV 561
Query: 747 RAVDGGVGHNQKTGIATVNITLLDINDNHPT-WKDAPYYINLVEMTPPDSDVTTVVAVDP 805
+A D ++ I TV I +L N+ P + Y + + E + + + A D
Sbjct: 562 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 621
Query: 806 DLGENGTLVYSIQ--PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDC 863
E ++ Y+I+ P + ++L+ TTG I T LDRE+ D R I++
Sbjct: 622 ---EGDSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTD-------RYILIITASD 670
Query: 864 GRPPLKATSSATVFVNLLDLNDNDPTFQN-LPFVAEVLEGIPAGVSIYQVVAIDLDEGLN 922
GRP TS+ATV + + D+NDN P F LP V+E A + QV A D D G+N
Sbjct: 671 GRPD--GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN 727
Query: 923 GLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLT 982
G V Y + G F I +S+G + T +L+RE Y+L VVA+D + ST TL
Sbjct: 728 GQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLA 784
Query: 983 IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGK 1042
I VLD++D +P F + Y V V E++P ++ + D D+G N +SY I V
Sbjct: 785 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHF 842
Query: 1043 FSVGYRDAVVRTVVGLDRET----TAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
F++ + + LD E A+ ++EA D G G ATV V V D+ND
Sbjct: 843 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDY 900
Query: 1099 RPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF--GRVWYR---ILHGNHGNNFRIH 1153
P+F + Y+ V D +G I + A DAD RV YR + + F +
Sbjct: 901 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
Query: 1154 VSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQY 1213
+G ++ L+ E + L+V A++ M SS V + V E P FTQ++Y
Sbjct: 961 EDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH-PGEIPRFTQEEY 1018
Query: 1214 SRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLD 1272
+ E A GT V V+ A + + Y I+SG E F I+ TG+I LD
Sbjct: 1019 RPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNGPLD 1074
Query: 1273 YETKTSYMMNVSA-------TDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILEN 1325
YET+TSY++ V A + P VYI + +E + F Y + E+
Sbjct: 1075 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1134
Query: 1326 LALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGD 1383
+ T ++RV+A D N + + YR + K F ++ TG+I L +
Sbjct: 1135 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRS 1194
Query: 1384 FYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
++ V+A DD G + V ++V+++ D
Sbjct: 1195 YFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 275 bits (703), Expect = 6e-73
Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 168
Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 169 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223
Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
L V +LD +D P+ P Y ++ E + ++
Sbjct: 224 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 283
Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 284 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 342
Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 343 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 402
Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 403 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 460
Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 461 AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 513
Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A D P
Sbjct: 514 ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 570
Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
+S V I VL N+ P L ++ ISE V + + ++ A+D + +T
Sbjct: 571 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 627
Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A +
Sbjct: 628 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 682
Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
I ++D NDN P+F + + A + G + A D D I V Y L G
Sbjct: 683 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 737
Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
+ LF I S+ + T V ++RE EL+++A D + +ST L I +LD +D
Sbjct: 738 NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
N P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F +H TG
Sbjct: 793 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 850
Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
++R + +++ S V A D GT+P G A VT+++ D+ND P F I
Sbjct: 851 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 909
Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
V A GT I + A D D ++ Y + DD P F V
Sbjct: 910 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 961
Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
++G V+ + +N E +++ + D+ V ++ TV +L ++ P+F
Sbjct: 962 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1014
Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
Y + E AT GT + ++A +N + Y+++ + + + G +
Sbjct: 1015 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1067
Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
N +DYE V + V ++ P ++ VY+EI D N++ P+F + Y
Sbjct: 1068 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1127
Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
V ED + T +L V ATD D+GN++++ Y L +G+ F + TG I
Sbjct: 1128 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1187
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
++ ++ +A D+ G S + + V VV Q+
Sbjct: 1188 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
Score = 274 bits (700), Expect = 1e-72
Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)
Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 79 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 135
Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 136 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195
Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 196 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 255
Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
+Y+AAI E L IV +ID I Y T
Sbjct: 256 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 315
Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375
Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
S I E PVG ++ + A D D L + F +
Sbjct: 376 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 434
Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 435 TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 490
Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 491 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 549
Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
++ Y L D P ++ VY+ ++ N+ +P F Q Y + + E
Sbjct: 550 EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 607
Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
+ L+ +QA D + ++TYAI G+ F + G++T K LD E S RY
Sbjct: 608 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 663
Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
LI+TA+D P TST TV + V D+NDN P F V E + V A
Sbjct: 664 LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 719
Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D +
Sbjct: 720 TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 774
Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++
Sbjct: 775 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 832
Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
I + + F ++ TG +++ R LD E P+ + +I+ + P IA
Sbjct: 833 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 888
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
+ + + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y
Sbjct: 889 -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 943
Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
++ Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A
Sbjct: 944 RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 999
Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
+ I +L + P F+ E PP S L T + +N +VY I +
Sbjct: 1000 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1051
Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
G +D F I+ +TGVI V N +D E + SY L V A V S TA V I
Sbjct: 1052 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1110
Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
I D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 1111 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1169
Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
++ F V TG + M +S +++AT + + A L V
Sbjct: 1170 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1218
Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
SV N + V V +V + K +T ++R ++ PG ++
Sbjct: 1219 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1263
Score = 223 bits (568), Expect = 2e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 368 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 425
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 426 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 483
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 484 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 543
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 544 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 602 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 658
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 659 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 711 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 758
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 759 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 817
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 818 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 875
Query: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 876 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 935
Query: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 936 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 991
Query: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 992 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1047
Query: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 1048 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1106
Query: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1166
Query: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 1167 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1217
Query: 878 VNLLDLNDNDPTFQNLP 894
V++++ D N+P
Sbjct: 1218 VSVVNQLDMQVIVSNVP 1234
Score = 87.0 bits (214), Expect = 3e-16
Identities = 123/509 (24%), Positives = 205/509 (40%), Gaps = 91/509 (17%)
Query: 2437 IEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVAS--------NR 2488
IE SL D + + + L+S R L +D P ++ S N+
Sbjct: 51 IELSLKDNVDYWVLMDPVKQMLFLNSTGR---------VLDRDPPMNIHSIVVQVQCINK 101
Query: 2489 RENSV---QVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM-----ATDQDEGP 2540
+ ++ +V I V D ND P F + +V E P GT++ T ATD D+GP
Sbjct: 102 KVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP 161
Query: 2541 NGELTYSLE-----GPGVEAFHVD-MDSGLVTTQRPLQSYEK--FSLTVVATDGGE---P 2589
NG++ Y ++ + F + M +G + ++ L +K + + + A D +
Sbjct: 162 NGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNE 221
Query: 2590 PLWGTTMLLVEVIDVNDNRPVF---VRPPN----------GTILHIREEIPLRSNVYE-- 2634
TT L V+V+D +D P+F V PN I +R L +
Sbjct: 222 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 281
Query: 2635 VYATDKDEGLNG-----AVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSL 2689
+ A D+D + + YS L FF + P + + + ++R+ + L
Sbjct: 282 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341
Query: 2690 ILVAS-DLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG 2748
++ A D G P+P L + + D ++ P F P S Q +L E +P G +
Sbjct: 342 VIKAEQDNGHPLP--AFAGLHIEILDENNQSPYFTMP---SYQGYIL---ESAPVGATIS 393
Query: 2749 ---NVTG-----AVDADEGPNAIVYYFIAAGNEEKNFHLQPDGC---LLVLRDLDREREA 2797
N+T A+D D + + F + G L +L+ +DRE +
Sbjct: 394 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 453
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
++F + A D V + V + + D ND P F + Y V T
Sbjct: 454 TYTFSITA---------------FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 498
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSIL 2886
D + G +IQ+ A+DAD G+N + Y IL
Sbjct: 499 DMRPGDSVIQLTAVDADEGSNGEITYEIL 527
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 290 bits (743), Expect = 1e-77
Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
Query: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 308 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 367 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 478 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
Query: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 537 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 543 TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
+ V I VL N+ + P F + Y + E L+ L+ATD + + ITY+I
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
+ + +L E G++++ + LD E Y+ ++ G P ST V I V
Sbjct: 654 NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707
Query: 662 FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
D NDN P F Y +SVVE A A V + ATD D GQ + YSL +
Sbjct: 708 TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761
Query: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+DN P
Sbjct: 762 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
+ ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ TG++
Sbjct: 819 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
+ LD E EA + + PP ATV V + D+ND P F +
Sbjct: 877 LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931
Query: 896 VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
V G I V A D D GL V YR + P F + SG V+T
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
L+ E ++L VVA D G P SS++T+ I VL E P F Y ++
Sbjct: 992 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050
Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
+ +V + + +N + Y I GN + F + V+ LD ET +Y+L +
Sbjct: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
+A + N V + + TA V++ + D N++ P+F + Y V ED S+L++
Sbjct: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 1125 KATDADEGEFGRVWYRIL 1142
KATD D G + + YR++
Sbjct: 1167 KATDKDTGNYSVMAYRLI 1184
Score = 284 bits (727), Expect = 9e-76
Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
I ++ L+G F ++ T +++ V D F ++ +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 369
Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++ A
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
D+D + + TG+ R +DREEQ++Y ++ A D V
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 487
Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
S IV I + D ND+ P F V V PG + +TA+D D N ++ Y
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
I LV Q D F +N TG + + + + TY +T+ DNA ER
Sbjct: 548 I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 594
Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
S+ + + VL N+ +P P + Y +E I E G L+ + A D +
Sbjct: 595 RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 647
Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
+TY + + P L +++ G + + +D E + ASD G P + V +
Sbjct: 648 ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705
Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
+ D+NDN P+FD + + + V ATD D+G + YSLG+ + F I
Sbjct: 706 VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 765
Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
+ G IY L+RE +D+Y L +A D A + R +++ + I+VLD++D P F+
Sbjct: 766 T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 820
Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
++ V EN PAGT+++ + A D D G N ++Y + P V+ F + +G ++ R
Sbjct: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 878
Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
L YE F + V A D G PP G + V V D+ND PVF + +
Sbjct: 879 SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 934
Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ + + + VYA D D GL + VRY F ++ SG + T
Sbjct: 935 -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
L+ E ++ L++VA D G+PV + + L P F + +Y+ V
Sbjct: 994 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1046
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
E + +GT+VG ++ A N + Y I +GNEE F + G + V LD E
Sbjct: 1047 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1101
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
+ V+A S L + + +V + ++D N+ PP F K Y GV+
Sbjct: 1102 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1155
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
DA++ + +++V A D D GN YS++A +R + ++ + F + + G+++T
Sbjct: 1156 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1207
Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
LF YF ++A D L+G D + + L D +V IV N P V
Sbjct: 1208 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1264
Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
E+ +L I GA +V + + H D ++ + +L ++ ++ TNR +D +
Sbjct: 1265 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1324
Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
+ + +D + F+ Y +L+++ +V + + + + A++ LA ++
Sbjct: 1325 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1384
Query: 3077 FLA---AMLFVLMNW 3088
L A+L VL+++
Sbjct: 1385 ILCCIPAILVVLVSY 1399
Score = 280 bits (716), Expect = 2e-74
Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)
Query: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 39 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94
Query: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 95 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149
Query: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207
Query: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 208 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263
Query: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
+F +PL Y ++ E N + T + + D + + +
Sbjct: 264 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323
Query: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 324 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
+LD N+ P F +Y G + E+ P ++T +R+ A D+D +
Sbjct: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
Query: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
+ + S F ++ +++ +P+D E+ +T + P V V I+
Sbjct: 444 F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498
Query: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y + Q
Sbjct: 499 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555
Query: 719 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
F IN +G IT ++ Y L V+A D ++ I TV I +L N+ P
Sbjct: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
+ Y + + E + + + A D E ++ Y+I+ P + ++L+ TTG I T
Sbjct: 616 FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
LDRE+ D R I++ GRP TS+ATV + + D+NDN P F LP
Sbjct: 672 LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722
Query: 895 FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
V+E A + QV A D D G+NG V Y + G F I +S+G + T +L+
Sbjct: 723 RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778
Query: 955 RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
RE Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++P +
Sbjct: 779 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838
Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
+ + D D+G N +SY I V F++ + + LD E A+ ++
Sbjct: 839 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
EA D G G ATV V V D+ND P+F + Y+ V D +G I + A DAD
Sbjct: 897 EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
RV YR + + F + +G ++ L+ E + L+V A++
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013
Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
M SS V + V E P FTQ++Y + E A GT V V+ A + +
Sbjct: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068
Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
Y I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
+ K F ++ TG+I L + ++ V+A DD G + V ++V+++ D
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 275 bits (703), Expect = 6e-73
Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 191 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
L V +LD +D P+ P Y ++ E + ++
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364
Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482
Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 483 AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A D P
Sbjct: 536 ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592
Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
+S V I VL N+ P L ++ ISE V + + ++ A+D + +T
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649
Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A +
Sbjct: 650 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704
Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
I ++D NDN P+F + + A + G + A D D I V Y L G
Sbjct: 705 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759
Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
+ LF I S+ + T V ++RE EL+++A D + +ST L I +LD +D
Sbjct: 760 NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
N P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F +H TG
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872
Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
++R + +++ S V A D GT+P G A VT+++ D+ND P F I
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
V A GT I + A D D ++ Y + DD P F V
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983
Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
++G V+ + +N E +++ + D+ V ++ TV +L ++ P+F
Sbjct: 984 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036
Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
Y + E AT GT + ++A +N + Y+++ + + + G +
Sbjct: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089
Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
N +DYE V + V ++ P ++ VY+EI D N++ P+F + Y
Sbjct: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149
Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
V ED + T +L V ATD D+GN++++ Y L +G+ F + TG I
Sbjct: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
++ ++ +A D+ G S + + V VV Q+
Sbjct: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Score = 274 bits (700), Expect = 1e-72
Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)
Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157
Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
+Y+AAI E L IV +ID I Y T
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
S I E PVG ++ + A D D L + F +
Sbjct: 398 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 457 TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512
Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571
Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
++ Y L D P ++ VY+ ++ N+ +P F Q Y + + E
Sbjct: 572 EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629
Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
+ L+ +QA D + ++TYAI G+ F + G++T K LD E S RY
Sbjct: 630 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685
Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
LI+TA+D P TST TV + V D+NDN P F V E + V A
Sbjct: 686 LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741
Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D +
Sbjct: 742 TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796
Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++
Sbjct: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854
Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
I + + F ++ TG +++ R LD E P+ + +I+ + P IA
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
+ + + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y
Sbjct: 911 -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965
Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
++ Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A
Sbjct: 966 RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021
Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
+ I +L + P F+ E PP S L T + +N +VY I +
Sbjct: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073
Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
G +D F I+ +TGVI V N +D E + SY L V A V S TA V I
Sbjct: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
I D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191
Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
++ F V TG + M +S +++AT + + A L V
Sbjct: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240
Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
SV N + V V +V + K +T ++R ++ PG ++
Sbjct: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285
Score = 223 bits (568), Expect = 2e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 390 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 566 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 624 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 681 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 733 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 781 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 840 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
Query: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 958 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013
Query: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069
Query: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239
Query: 878 VNLLDLNDNDPTFQNLP 894
V++++ D N+P
Sbjct: 1240 VSVVNQLDMQVIVSNVP 1256
Score = 89.0 bits (219), Expect = 7e-17
Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)
Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
P+ A+ E+ GTI++ + G IE SL D + + + L+S
Sbjct: 40 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
R L +D P ++ S N++ ++ +V I V D ND P F
Sbjct: 100 GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150
Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
+ +V E P GT++ T ATD D+GPNG++ Y ++ + F + M
Sbjct: 151 SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210
Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
+G + ++ L +K + + + A D + TT L V+V+D +D P+F V
Sbjct: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
PN I +R L + + A D+D + + YS L
Sbjct: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
FF + P + + + ++R+ + L++ A D G P+P L + + D
Sbjct: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388
Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
++ P F P S Q +L E +P G + N+T A+D D
Sbjct: 389 NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442
Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
+ + F + G L +L+ +DRE + ++F + A D V
Sbjct: 443 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487
Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
+ V + + D ND P F + Y V TD + G +IQ+ A+DAD G+N + Y
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2885 IL 2886
IL
Sbjct: 548 IL 549
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 290 bits (743), Expect = 1e-77
Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 133 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 192
Query: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 193 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252
Query: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 253 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 313 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 371
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 372 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 428 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 482
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 483 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 541
Query: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 542 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 601
Query: 543 TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
+ V I VL N+ + P F + Y + E L+ L+ATD + + ITY+I
Sbjct: 602 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 658
Query: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
+ + +L E G++++ + LD E Y+ ++ G P ST V I V
Sbjct: 659 NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 712
Query: 662 FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
D NDN P F Y +SVVE A A V + ATD D GQ + YSL +
Sbjct: 713 TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 766
Query: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+DN P
Sbjct: 767 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 823
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
+ ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ TG++
Sbjct: 824 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 881
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
+ LD E EA + + PP ATV V + D+ND P F +
Sbjct: 882 LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 936
Query: 896 VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
V G I V A D D GL V YR + P F + SG V+T
Sbjct: 937 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 996
Query: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
L+ E ++L VVA D G P SS++T+ I VL E P F Y ++
Sbjct: 997 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1055
Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
+ +V + + +N + Y I GN + F + V+ LD ET +Y+L +
Sbjct: 1056 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1112
Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
+A + N V + + TA V++ + D N++ P+F + Y V ED S+L++
Sbjct: 1113 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1171
Query: 1125 KATDADEGEFGRVWYRIL 1142
KATD D G + + YR++
Sbjct: 1172 KATDKDTGNYSVMAYRLI 1189
Score = 284 bits (727), Expect = 9e-76
Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
I ++ L+G F ++ T +++ V D F ++ +
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 374
Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++ A
Sbjct: 375 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
D+D + + TG+ R +DREEQ++Y ++ A D V
Sbjct: 435 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 492
Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
S IV I + D ND+ P F V V PG + +TA+D D N ++ Y
Sbjct: 493 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 552
Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
I LV Q D F +N TG + + + + TY +T+ DNA ER
Sbjct: 553 I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 599
Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
S+ + + VL N+ +P P + Y +E I E G L+ + A D +
Sbjct: 600 RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 652
Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
+TY + + P L +++ G + + +D E + ASD G P + V +
Sbjct: 653 ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 710
Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
+ D+NDN P+FD + + + V ATD D+G + YSLG+ + F I
Sbjct: 711 VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 770
Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
+ G IY L+RE +D+Y L +A D A + R +++ + I+VLD++D P F+
Sbjct: 771 T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 825
Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
++ V EN PAGT+++ + A D D G N ++Y + P V+ F + +G ++ R
Sbjct: 826 NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 883
Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
L YE F + V A D G PP G + V V D+ND PVF + +
Sbjct: 884 SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 939
Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ + + + VYA D D GL + VRY F ++ SG + T
Sbjct: 940 -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 998
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
L+ E ++ L++VA D G+PV + + L P F + +Y+ V
Sbjct: 999 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1051
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
E + +GT+VG ++ A N + Y I +GNEE F + G + V LD E
Sbjct: 1052 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1106
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
+ V+A S L + + +V + ++D N+ PP F K Y GV+
Sbjct: 1107 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1160
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
DA++ + +++V A D D GN YS++A +R + ++ + F + + G+++T
Sbjct: 1161 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1212
Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
LF YF ++A D L+G D + + L D +V IV N P V
Sbjct: 1213 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1269
Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
E+ +L I GA +V + + H D ++ + +L ++ ++ TNR +D +
Sbjct: 1270 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1329
Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
+ + +D + F+ Y +L+++ +V + + + + A++ LA ++
Sbjct: 1330 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1389
Query: 3077 FLA---AMLFVLMNW 3088
L A+L VL+++
Sbjct: 1390 ILCCIPAILVVLVSY 1404
Score = 280 bits (716), Expect = 2e-74
Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)
Query: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 44 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 99
Query: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 100 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 154
Query: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 155 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 212
Query: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 213 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 268
Query: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
+F +PL Y ++ E N + T + + D + + +
Sbjct: 269 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 328
Query: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 329 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 388
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
+LD N+ P F +Y G + E+ P ++T +R+ A D+D +
Sbjct: 389 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 448
Query: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
+ + S F ++ +++ +P+D E+ +T + P V V I+
Sbjct: 449 F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 503
Query: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y + Q
Sbjct: 504 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 560
Query: 719 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
F IN +G IT ++ Y L V+A D ++ I TV I +L N+ P
Sbjct: 561 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 620
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
+ Y + + E + + + A D E ++ Y+I+ P + ++L+ TTG I T
Sbjct: 621 FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 676
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
LDRE+ D R I++ GRP TS+ATV + + D+NDN P F LP
Sbjct: 677 LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 727
Query: 895 FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
V+E A + QV A D D G+NG V Y + G F I +S+G + T +L+
Sbjct: 728 RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 783
Query: 955 RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
RE Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++P +
Sbjct: 784 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 843
Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
+ + D D+G N +SY I V F++ + + LD E A+ ++
Sbjct: 844 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 901
Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
EA D G G ATV V V D+ND P+F + Y+ V D +G I + A DAD
Sbjct: 902 EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 959
Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
RV YR + + F + +G ++ L+ E + L+V A++
Sbjct: 960 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1018
Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
M SS V + V E P FTQ++Y + E A GT V V+ A + +
Sbjct: 1019 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1073
Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
Y I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 1074 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1133
Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1193
Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
+ K F ++ TG+I L + ++ V+A DD G + V ++V+++ D
Sbjct: 1194 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252
Score = 275 bits (703), Expect = 6e-73
Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 195
Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 196 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
L V +LD +D P+ P Y ++ E + ++
Sbjct: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 369
Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 370 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 430 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 487
Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 488 AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540
Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A D P
Sbjct: 541 ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 597
Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
+S V I VL N+ P L ++ ISE V + + ++ A+D + +T
Sbjct: 598 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 654
Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A +
Sbjct: 655 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 709
Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
I ++D NDN P+F + + A + G + A D D I V Y L G
Sbjct: 710 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 764
Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
+ LF I S+ + T V ++RE EL+++A D + +ST L I +LD +D
Sbjct: 765 NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 819
Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
N P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F +H TG
Sbjct: 820 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 877
Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
++R + +++ S V A D GT+P G A VT+++ D+ND P F I
Sbjct: 878 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 936
Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
V A GT I + A D D ++ Y + DD P F V
Sbjct: 937 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 988
Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
++G V+ + +N E +++ + D+ V ++ TV +L ++ P+F
Sbjct: 989 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1041
Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
Y + E AT GT + ++A +N + Y+++ + + + G +
Sbjct: 1042 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1094
Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
N +DYE V + V ++ P ++ VY+EI D N++ P+F + Y
Sbjct: 1095 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1154
Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
V ED + T +L V ATD D+GN++++ Y L +G+ F + TG I
Sbjct: 1155 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1214
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
++ ++ +A D+ G S + + V VV Q+
Sbjct: 1215 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1251
Score = 274 bits (700), Expect = 1e-72
Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)
Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 106 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 162
Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 163 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222
Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 223 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282
Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
+Y+AAI E L IV +ID I Y T
Sbjct: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342
Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
S I E PVG ++ + A D D L + F +
Sbjct: 403 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 461
Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 462 TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 517
Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 518 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 576
Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
++ Y L D P ++ VY+ ++ N+ +P F Q Y + + E
Sbjct: 577 EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 634
Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
+ L+ +QA D + ++TYAI G+ F + G++T K LD E S RY
Sbjct: 635 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 690
Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
LI+TA+D P TST TV + V D+NDN P F V E + V A
Sbjct: 691 LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 746
Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D +
Sbjct: 747 TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 801
Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++
Sbjct: 802 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 859
Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
I + + F ++ TG +++ R LD E P+ + +I+ + P IA
Sbjct: 860 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 915
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
+ + + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y
Sbjct: 916 -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 970
Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
++ Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A
Sbjct: 971 RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1026
Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
+ I +L + P F+ E PP S L T + +N +VY I +
Sbjct: 1027 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1078
Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
G +D F I+ +TGVI V N +D E + SY L V A V S TA V I
Sbjct: 1079 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1137
Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
I D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 1138 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1196
Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
++ F V TG + M +S +++AT + + A L V
Sbjct: 1197 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1245
Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
SV N + V V +V + K +T ++R ++ PG ++
Sbjct: 1246 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1290
Score = 223 bits (568), Expect = 2e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 395 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 452
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 453 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 510
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 511 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 570
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 571 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 628
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 629 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 685
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 686 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 737
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 738 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 785
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 786 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 844
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 845 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 902
Query: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 903 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 962
Query: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 963 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1018
Query: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 1019 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1074
Query: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 1075 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1133
Query: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1193
Query: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 1194 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1244
Query: 878 VNLLDLNDNDPTFQNLP 894
V++++ D N+P
Sbjct: 1245 VSVVNQLDMQVIVSNVP 1261
Score = 89.0 bits (219), Expect = 7e-17
Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)
Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
P+ A+ E+ GTI++ + G IE SL D + + + L+S
Sbjct: 45 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 104
Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
R L +D P ++ S N++ ++ +V I V D ND P F
Sbjct: 105 GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 155
Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
+ +V E P GT++ T ATD D+GPNG++ Y ++ + F + M
Sbjct: 156 SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 215
Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
+G + ++ L +K + + + A D + TT L V+V+D +D P+F V
Sbjct: 216 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 275
Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
PN I +R L + + A D+D + + YS L
Sbjct: 276 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335
Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
FF + P + + + ++R+ + L++ A D G P+P L + + D
Sbjct: 336 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 393
Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
++ P F P S Q +L E +P G + N+T A+D D
Sbjct: 394 NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 447
Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
+ + F + G L +L+ +DRE + ++F + A D V
Sbjct: 448 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 492
Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
+ V + + D ND P F + Y V TD + G +IQ+ A+DAD G+N + Y
Sbjct: 493 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 552
Query: 2885 IL 2886
IL
Sbjct: 553 IL 554
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 290 bits (743), Expect = 1e-77
Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
Query: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 308 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 367 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 478 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
Query: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 537 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 543 TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
+ V I VL N+ + P F + Y + E L+ L+ATD + + ITY+I
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
+ + +L E G++++ + LD E Y+ ++ G P ST V I V
Sbjct: 654 NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707
Query: 662 FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
D NDN P F Y +SVVE A A V + ATD D GQ + YSL +
Sbjct: 708 TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761
Query: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+DN P
Sbjct: 762 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
+ ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ TG++
Sbjct: 819 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
+ LD E EA + + PP ATV V + D+ND P F +
Sbjct: 877 LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931
Query: 896 VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
V G I V A D D GL V YR + P F + SG V+T
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
L+ E ++L VVA D G P SS++T+ I VL E P F Y ++
Sbjct: 992 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050
Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
+ +V + + +N + Y I GN + F + V+ LD ET +Y+L +
Sbjct: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
+A + N V + + TA V++ + D N++ P+F + Y V ED S+L++
Sbjct: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 1125 KATDADEGEFGRVWYRIL 1142
KATD D G + + YR++
Sbjct: 1167 KATDKDTGNYSVMAYRLI 1184
Score = 284 bits (727), Expect = 9e-76
Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
I ++ L+G F ++ T +++ V D F ++ +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 369
Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++ A
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
D+D + + TG+ R +DREEQ++Y ++ A D V
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 487
Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
S IV I + D ND+ P F V V PG + +TA+D D N ++ Y
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
I LV Q D F +N TG + + + + TY +T+ DNA ER
Sbjct: 548 I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 594
Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
S+ + + VL N+ +P P + Y +E I E G L+ + A D +
Sbjct: 595 RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 647
Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
+TY + + P L +++ G + + +D E + ASD G P + V +
Sbjct: 648 ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705
Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
+ D+NDN P+FD + + + V ATD D+G + YSLG+ + F I
Sbjct: 706 VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 765
Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
+ G IY L+RE +D+Y L +A D A + R +++ + I+VLD++D P F+
Sbjct: 766 T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 820
Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
++ V EN PAGT+++ + A D D G N ++Y + P V+ F + +G ++ R
Sbjct: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 878
Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
L YE F + V A D G PP G + V V D+ND PVF + +
Sbjct: 879 SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 934
Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ + + + VYA D D GL + VRY F ++ SG + T
Sbjct: 935 -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
L+ E ++ L++VA D G+PV + + L P F + +Y+ V
Sbjct: 994 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1046
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
E + +GT+VG ++ A N + Y I +GNEE F + G + V LD E
Sbjct: 1047 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1101
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
+ V+A S L + + +V + ++D N+ PP F K Y GV+
Sbjct: 1102 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1155
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
DA++ + +++V A D D GN YS++A +R + ++ + F + + G+++T
Sbjct: 1156 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1207
Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
LF YF ++A D L+G D + + L D +V IV N P V
Sbjct: 1208 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1264
Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
E+ +L I GA +V + + H D ++ + +L ++ ++ TNR +D +
Sbjct: 1265 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1324
Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
+ + +D + F+ Y +L+++ +V + + + + A++ LA ++
Sbjct: 1325 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1384
Query: 3077 FLA---AMLFVLMNW 3088
L A+L VL+++
Sbjct: 1385 ILCCIPAILVVLVSY 1399
Score = 280 bits (716), Expect = 2e-74
Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)
Query: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 39 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94
Query: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 95 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149
Query: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207
Query: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 208 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263
Query: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
+F +PL Y ++ E N + T + + D + + +
Sbjct: 264 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323
Query: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 324 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
+LD N+ P F +Y G + E+ P ++T +R+ A D+D +
Sbjct: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
Query: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
+ + S F ++ +++ +P+D E+ +T + P V V I+
Sbjct: 444 F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498
Query: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y + Q
Sbjct: 499 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555
Query: 719 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
F IN +G IT ++ Y L V+A D ++ I TV I +L N+ P
Sbjct: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
+ Y + + E + + + A D E ++ Y+I+ P + ++L+ TTG I T
Sbjct: 616 FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
LDRE+ D R I++ GRP TS+ATV + + D+NDN P F LP
Sbjct: 672 LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722
Query: 895 FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
V+E A + QV A D D G+NG V Y + G F I +S+G + T +L+
Sbjct: 723 RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778
Query: 955 RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
RE Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++P +
Sbjct: 779 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838
Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
+ + D D+G N +SY I V F++ + + LD E A+ ++
Sbjct: 839 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
EA D G G ATV V V D+ND P+F + Y+ V D +G I + A DAD
Sbjct: 897 EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
RV YR + + F + +G ++ L+ E + L+V A++
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013
Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
M SS V + V E P FTQ++Y + E A GT V V+ A + +
Sbjct: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068
Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
Y I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
+ K F ++ TG+I L + ++ V+A DD G + V ++V+++ D
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 275 bits (703), Expect = 6e-73
Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 191 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
L V +LD +D P+ P Y ++ E + ++
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364
Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482
Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 483 AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A D P
Sbjct: 536 ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592
Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
+S V I VL N+ P L ++ ISE V + + ++ A+D + +T
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649
Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A +
Sbjct: 650 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704
Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
I ++D NDN P+F + + A + G + A D D I V Y L G
Sbjct: 705 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759
Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
+ LF I S+ + T V ++RE EL+++A D + +ST L I +LD +D
Sbjct: 760 NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
N P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F +H TG
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872
Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
++R + +++ S V A D GT+P G A VT+++ D+ND P F I
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
V A GT I + A D D ++ Y + DD P F V
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983
Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
++G V+ + +N E +++ + D+ V ++ TV +L ++ P+F
Sbjct: 984 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036
Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
Y + E AT GT + ++A +N + Y+++ + + + G +
Sbjct: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089
Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
N +DYE V + V ++ P ++ VY+EI D N++ P+F + Y
Sbjct: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149
Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
V ED + T +L V ATD D+GN++++ Y L +G+ F + TG I
Sbjct: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
++ ++ +A D+ G S + + V VV Q+
Sbjct: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Score = 274 bits (700), Expect = 1e-72
Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)
Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157
Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
+Y+AAI E L IV +ID I Y T
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
S I E PVG ++ + A D D L + F +
Sbjct: 398 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 457 TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512
Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571
Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
++ Y L D P ++ VY+ ++ N+ +P F Q Y + + E
Sbjct: 572 EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629
Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
+ L+ +QA D + ++TYAI G+ F + G++T K LD E S RY
Sbjct: 630 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685
Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
LI+TA+D P TST TV + V D+NDN P F V E + V A
Sbjct: 686 LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741
Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D +
Sbjct: 742 TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796
Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++
Sbjct: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854
Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
I + + F ++ TG +++ R LD E P+ + +I+ + P IA
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
+ + + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y
Sbjct: 911 -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965
Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
++ Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A
Sbjct: 966 RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021
Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
+ I +L + P F+ E PP S L T + +N +VY I +
Sbjct: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073
Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
G +D F I+ +TGVI V N +D E + SY L V A V S TA V I
Sbjct: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
I D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191
Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
++ F V TG + M +S +++AT + + A L V
Sbjct: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240
Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
SV N + V V +V + K +T ++R ++ PG ++
Sbjct: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285
Score = 223 bits (568), Expect = 2e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 390 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 566 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 624 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 681 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 733 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 781 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 840 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
Query: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 958 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013
Query: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069
Query: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239
Query: 878 VNLLDLNDNDPTFQNLP 894
V++++ D N+P
Sbjct: 1240 VSVVNQLDMQVIVSNVP 1256
Score = 89.0 bits (219), Expect = 7e-17
Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)
Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
P+ A+ E+ GTI++ + G IE SL D + + + L+S
Sbjct: 40 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
R L +D P ++ S N++ ++ +V I V D ND P F
Sbjct: 100 GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150
Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
+ +V E P GT++ T ATD D+GPNG++ Y ++ + F + M
Sbjct: 151 SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210
Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
+G + ++ L +K + + + A D + TT L V+V+D +D P+F V
Sbjct: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
PN I +R L + + A D+D + + YS L
Sbjct: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
FF + P + + + ++R+ + L++ A D G P+P L + + D
Sbjct: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388
Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
++ P F P S Q +L E +P G + N+T A+D D
Sbjct: 389 NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442
Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
+ + F + G L +L+ +DRE + ++F + A D V
Sbjct: 443 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487
Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
+ V + + D ND P F + Y V TD + G +IQ+ A+DAD G+N + Y
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2885 IL 2886
IL
Sbjct: 548 IL 549
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 290 bits (743), Expect = 1e-77
Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 106 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 165
Query: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 166 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 225
Query: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 226 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 285
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 286 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 344
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 345 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 400
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 401 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 455
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 456 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 514
Query: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 515 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 574
Query: 543 TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
+ V I VL N+ + P F + Y + E L+ L+ATD + + ITY+I
Sbjct: 575 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 631
Query: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
+ + +L E G++++ + LD E Y+ ++ G P ST V I V
Sbjct: 632 NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 685
Query: 662 FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
D NDN P F Y +SVVE A A V + ATD D GQ + YSL +
Sbjct: 686 TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 739
Query: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+DN P
Sbjct: 740 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 796
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
+ ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ TG++
Sbjct: 797 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 854
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
+ LD E EA + + PP ATV V + D+ND P F +
Sbjct: 855 LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 909
Query: 896 VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
V G I V A D D GL V YR + P F + SG V+T
Sbjct: 910 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 969
Query: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
L+ E ++L VVA D G P SS++T+ I VL E P F Y ++
Sbjct: 970 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1028
Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
+ +V + + +N + Y I GN + F + V+ LD ET +Y+L +
Sbjct: 1029 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1085
Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
+A + N V + + TA V++ + D N++ P+F + Y V ED S+L++
Sbjct: 1086 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1144
Query: 1125 KATDADEGEFGRVWYRIL 1142
KATD D G + + YR++
Sbjct: 1145 KATDKDTGNYSVMAYRLI 1162
Score = 284 bits (727), Expect = 9e-76
Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 111 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 170
Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 171 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 230
Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 231 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 290
Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
I ++ L+G F ++ T +++ V D F ++ +
Sbjct: 291 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 347
Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++ A
Sbjct: 348 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 407
Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
D+D + + TG+ R +DREEQ++Y ++ A D V
Sbjct: 408 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 465
Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
S IV I + D ND+ P F V V PG + +TA+D D N ++ Y
Sbjct: 466 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 525
Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
I LV Q D F +N TG + + + + TY +T+ DNA ER
Sbjct: 526 I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 572
Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
S+ + + VL N+ +P P + Y +E I E G L+ + A D +
Sbjct: 573 RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 625
Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
+TY + + P L +++ G + + +D E + ASD G P + V +
Sbjct: 626 ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 683
Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
+ D+NDN P+FD + + + V ATD D+G + YSLG+ + F I
Sbjct: 684 VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 743
Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
+ G IY L+RE +D+Y L +A D A + R +++ + I+VLD++D P F+
Sbjct: 744 T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 798
Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
++ V EN PAGT+++ + A D D G N ++Y + P V+ F + +G ++ R
Sbjct: 799 NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 856
Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
L YE F + V A D G PP G + V V D+ND PVF + +
Sbjct: 857 SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 912
Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ + + + VYA D D GL + VRY F ++ SG + T
Sbjct: 913 -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 971
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
L+ E ++ L++VA D G+PV + + L P F + +Y+ V
Sbjct: 972 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1024
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
E + +GT+VG ++ A N + Y I +GNEE F + G + V LD E
Sbjct: 1025 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1079
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
+ V+A S L + + +V + ++D N+ PP F K Y GV+
Sbjct: 1080 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1133
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
DA++ + +++V A D D GN YS++A +R + ++ + F + + G+++T
Sbjct: 1134 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1185
Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
LF YF ++A D L+G D + + L D +V IV N P V
Sbjct: 1186 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1242
Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
E+ +L I GA +V + + H D ++ + +L ++ ++ TNR +D +
Sbjct: 1243 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1302
Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
+ + +D + F+ Y +L+++ +V + + + + A++ LA ++
Sbjct: 1303 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1362
Query: 3077 FLA---AMLFVLMNW 3088
L A+L VL+++
Sbjct: 1363 ILCCIPAILVVLVSY 1377
Score = 279 bits (714), Expect = 3e-74
Identities = 330/1231 (26%), Positives = 525/1231 (42%), Gaps = 128/1231 (10%)
Query: 265 KGRPRGIGYTI---VSGNTNSIFALDYISGVLTLNG---LLDRENPLYSHGFILTVKGTE 318
KG G TI + N + +D + +L LN +LDR+ P+ H ++ V+
Sbjct: 41 KGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCIN 100
Query: 319 LNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQ----VV 374
+ I+V D NDN+P F Y + EL VG +
Sbjct: 101 KK-----VGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGAT 155
Query: 375 DKDENLGLNSMFEVYLVGN----NSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFD 430
D D+ G N E + N S+ P + G +R R L+YE RY
Sbjct: 156 DIDD--GPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKR----LNYEDKTRYFVI 209
Query: 431 LFANESVPD----HVGYAKVKITLINENDNRPIF-----------SQPL-YNISLYE--- 471
+ AN+ + + + +++ +D P+F +PL Y ++ E
Sbjct: 210 IQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRT 269
Query: 472 ----NVTVGTSVLTVLATDNDAGTFGE---VSYFF-----SDDPDRFSLDKDTGLIMLIA 519
N + T + + D + + + Y D P F + T + L+
Sbjct: 270 PEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE 329
Query: 520 RLDYELIQRFTLTIIARDGGGEETTG--RVRINVLDVNDNVPTFQKDAYVGALRENEP-- 575
++ + Q+F L I A G + I +LD N+ P F +Y G + E+ P
Sbjct: 330 PVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVG 389
Query: 576 -------SVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLD 628
++T +R+ A D+D + + + S F ++ +++ +P+D
Sbjct: 390 ATISDSLNLTSPLRIVALDKDIEDTKDPELHLF-LNDYTSVFTVTQTGITRYLTLLQPVD 448
Query: 629 YEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGA 688
E+ +T + P V V I+V D NDN PTF + +Y V V ++ G
Sbjct: 449 REEQQTYTFSITAFDGVQESEP----VIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGD 504
Query: 689 TVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIV 746
+V+ L A D D E I Y + Q F IN +G IT ++ Y L V
Sbjct: 505 SVIQLTAVDAD---EGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTV 561
Query: 747 RAVDGGVGHNQKTGIATVNITLLDINDNHPT-WKDAPYYINLVEMTPPDSDVTTVVAVDP 805
+A D ++ I TV I +L N+ P + Y + + E + + + A D
Sbjct: 562 QAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDR 621
Query: 806 DLGENGTLVYSIQ--PPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDC 863
E ++ Y+I+ P + ++L+ TTG I T LDRE+ D R I++
Sbjct: 622 ---EGDSITYAIENGDPQRVFNLSETTG-ILTLGKALDRESTD-------RYILIITASD 670
Query: 864 GRPPLKATSSATVFVNLLDLNDNDPTFQN-LPFVAEVLEGIPAGVSIYQVVAIDLDEGLN 922
GRP TS+ATV + + D+NDN P F LP V+E A + QV A D D G+N
Sbjct: 671 GRPD--GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVKATDPDAGIN 727
Query: 923 GLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLT 982
G V Y + G F I +S+G + T +L+RE Y+L VVA+D + ST TL
Sbjct: 728 GQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLA 784
Query: 983 IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGK 1042
I VLD++D +P F + Y V V E++P ++ + D D+G N +SY I V
Sbjct: 785 IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHF 842
Query: 1043 FSVGYRDAVVRTVVGLDRET----TAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDN 1098
F++ + + LD E A+ ++EA D G G ATV V V D+ND
Sbjct: 843 FALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFD--IYGTMPPGIATVTVIVKDMNDY 900
Query: 1099 RPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEF--GRVWYR---ILHGNHGNNFRIH 1153
P+F + Y+ V D +G I + A DAD RV YR + + F +
Sbjct: 901 PPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVE 960
Query: 1154 VSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDINDEAPVFTQQQY 1213
+G ++ L+ E + L+V A++ M SS V + V E P FTQ++Y
Sbjct: 961 EDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLH-PGEIPRFTQEEY 1018
Query: 1214 SRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSG-AEGKFEIDESTGLIITVNYLD 1272
+ E A GT V V+ A + + Y I+SG E F I+ TG+I LD
Sbjct: 1019 RPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGINNITGVIYVNGPLD 1074
Query: 1273 YETKTSYMMNVSA-------TDQAPPFNQGFCSVYITLLNELDEAVQFSNASYEAAILEN 1325
YET+TSY++ V A + P VYI + +E + F Y + E+
Sbjct: 1075 YETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSED 1134
Query: 1326 LALGTEIVRVQAYSID--NLNQITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGD 1383
+ T ++RV+A D N + + YR + K F ++ TG+I L +
Sbjct: 1135 ARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRS 1194
Query: 1384 FYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
++ V+A DD G + V ++V+++ D
Sbjct: 1195 YFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1225
Score = 275 bits (703), Expect = 6e-73
Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 110 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 168
Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 169 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 223
Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
L V +LD +D P+ P Y ++ E + ++
Sbjct: 224 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 283
Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 284 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 342
Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 343 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 402
Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 403 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 460
Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 461 AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 513
Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A D P
Sbjct: 514 ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 570
Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
+S V I VL N+ P L ++ ISE V + + ++ A+D + +T
Sbjct: 571 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 627
Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A +
Sbjct: 628 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 682
Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
I ++D NDN P+F + + A + G + A D D I V Y L G
Sbjct: 683 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 737
Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
+ LF I S+ + T V ++RE EL+++A D + +ST L I +LD +D
Sbjct: 738 NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 792
Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
N P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F +H TG
Sbjct: 793 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 850
Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
++R + +++ S V A D GT+P G A VT+++ D+ND P F I
Sbjct: 851 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 909
Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
V A GT I + A D D ++ Y + DD P F V
Sbjct: 910 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 961
Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
++G V+ + +N E +++ + D+ V ++ TV +L ++ P+F
Sbjct: 962 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1014
Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
Y + E AT GT + ++A +N + Y+++ + + + G +
Sbjct: 1015 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1067
Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
N +DYE V + V ++ P ++ VY+EI D N++ P+F + Y
Sbjct: 1068 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1127
Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
V ED + T +L V ATD D+GN++++ Y L +G+ F + TG I
Sbjct: 1128 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1187
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
++ ++ +A D+ G S + + V VV Q+
Sbjct: 1188 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1224
Score = 274 bits (700), Expect = 1e-72
Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)
Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 79 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 135
Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 136 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 195
Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 196 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 255
Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
+Y+AAI E L IV +ID I Y T
Sbjct: 256 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 315
Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 316 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 375
Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
S I E PVG ++ + A D D L + F +
Sbjct: 376 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 434
Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 435 TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 490
Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 491 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 549
Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
++ Y L D P ++ VY+ ++ N+ +P F Q Y + + E
Sbjct: 550 EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 607
Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
+ L+ +QA D + ++TYAI G+ F + G++T K LD E S RY
Sbjct: 608 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 663
Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
LI+TA+D P TST TV + V D+NDN P F V E + V A
Sbjct: 664 LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 719
Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D +
Sbjct: 720 TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 774
Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++
Sbjct: 775 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 832
Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
I + + F ++ TG +++ R LD E P+ + +I+ + P IA
Sbjct: 833 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 888
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
+ + + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y
Sbjct: 889 -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 943
Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
++ Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A
Sbjct: 944 RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 999
Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
+ I +L + P F+ E PP S L T + +N +VY I +
Sbjct: 1000 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1051
Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
G +D F I+ +TGVI V N +D E + SY L V A V S TA V I
Sbjct: 1052 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1110
Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
I D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 1111 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1169
Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
++ F V TG + M +S +++AT + + A L V
Sbjct: 1170 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1218
Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
SV N + V V +V + K +T ++R ++ PG ++
Sbjct: 1219 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1263
Score = 223 bits (568), Expect = 2e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 368 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 425
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 426 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 483
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 484 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 543
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 544 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 602 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 658
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 659 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 710
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 711 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 758
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 759 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 817
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 818 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 875
Query: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 876 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 935
Query: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 936 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 991
Query: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 992 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1047
Query: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 1048 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1106
Query: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 1107 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1166
Query: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 1167 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1217
Query: 878 VNLLDLNDNDPTFQNLP 894
V++++ D N+P
Sbjct: 1218 VSVVNQLDMQVIVSNVP 1234
Score = 87.0 bits (214), Expect = 3e-16
Identities = 123/509 (24%), Positives = 205/509 (40%), Gaps = 91/509 (17%)
Query: 2437 IEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVAS--------NR 2488
IE SL D + + + L+S R L +D P ++ S N+
Sbjct: 51 IELSLKDNVDYWVLMDPVKQMLFLNSTGR---------VLDRDPPMNIHSIVVQVQCINK 101
Query: 2489 RENSV---QVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM-----ATDQDEGP 2540
+ ++ +V I V D ND P F + +V E P GT++ T ATD D+GP
Sbjct: 102 KVGTIIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGP 161
Query: 2541 NGELTYSLE-----GPGVEAFHVD-MDSGLVTTQRPLQSYEK--FSLTVVATDGGE---P 2589
NG++ Y ++ + F + M +G + ++ L +K + + + A D +
Sbjct: 162 NGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNE 221
Query: 2590 PLWGTTMLLVEVIDVNDNRPVF---VRPPN----------GTILHIREEIPLRSNVYE-- 2634
TT L V+V+D +D P+F V PN I +R L +
Sbjct: 222 RRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPP 281
Query: 2635 VYATDKDEGLNG-----AVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSL 2689
+ A D+D + + YS L FF + P + + + ++R+ + L
Sbjct: 282 IQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDL 341
Query: 2690 ILVAS-DLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG 2748
++ A D G P+P L + + D ++ P F P S Q +L E +P G +
Sbjct: 342 VIKAEQDNGHPLP--AFAGLHIEILDENNQSPYFTMP---SYQGYIL---ESAPVGATIS 393
Query: 2749 ---NVTG-----AVDADEGPNAIVYYFIAAGNEEKNFHLQPDGC---LLVLRDLDREREA 2797
N+T A+D D + + F + G L +L+ +DRE +
Sbjct: 394 DSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQ 453
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
++F + A D V + V + + D ND P F + Y V T
Sbjct: 454 TYTFSITA---------------FDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYT 498
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSIL 2886
D + G +IQ+ A+DAD G+N + Y IL
Sbjct: 499 DMRPGDSVIQLTAVDADEGSNGEITYEIL 527
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 290 bits (743), Expect = 1e-77
Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
Query: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 308 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 367 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 478 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
Query: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 537 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 543 TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
+ V I VL N+ + P F + Y + E L+ L+ATD + + ITY+I
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
+ + +L E G++++ + LD E Y+ ++ G P ST V I V
Sbjct: 654 NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707
Query: 662 FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
D NDN P F Y +SVVE A A V + ATD D GQ + YSL +
Sbjct: 708 TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761
Query: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+DN P
Sbjct: 762 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
+ ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ TG++
Sbjct: 819 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
+ LD E EA + + PP ATV V + D+ND P F +
Sbjct: 877 LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931
Query: 896 VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
V G I V A D D GL V YR + P F + SG V+T
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
L+ E ++L VVA D G P SS++T+ I VL E P F Y ++
Sbjct: 992 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050
Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
+ +V + + +N + Y I GN + F + V+ LD ET +Y+L +
Sbjct: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
+A + N V + + TA V++ + D N++ P+F + Y V ED S+L++
Sbjct: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 1125 KATDADEGEFGRVWYRIL 1142
KATD D G + + YR++
Sbjct: 1167 KATDKDTGNYSVMAYRLI 1184
Score = 286 bits (732), Expect = 2e-76
Identities = 346/1350 (25%), Positives = 584/1350 (43%), Gaps = 151/1350 (11%)
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
I ++ L+G F ++ T +++ V D F ++ +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 369
Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++ A
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
D+D + + TG+ R +DREEQ++Y ++ A D V
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 487
Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
S IV I + D ND+ P F V V PG + +TA+D D N ++ Y
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
I LV Q D F +N TG + + + + TY +T+ DNA ER
Sbjct: 548 I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 594
Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
S+ + + VL N+ +P P + Y +E I E G L+ + A D +
Sbjct: 595 RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 647
Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
+TY + + P L +++ G + + +D E + ASD G P + V +
Sbjct: 648 ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705
Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
+ D+NDN P+FD + + + V ATD D+G + YSLG+ + F I
Sbjct: 706 VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 765
Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
+ G IY L+RE +D+Y L +A D A + R +++ + I+VLD++D P F+
Sbjct: 766 T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 820
Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
++ V EN PAGT+++ + A D D G N ++Y + P V+ F + +G ++ R
Sbjct: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 878
Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
L YE F + V A D G PP G + V V D+ND PVF + +
Sbjct: 879 SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 934
Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ + + + VYA D D GL + VRY F ++ SG + T
Sbjct: 935 -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
L+ E ++ L++VA D G+PV + + L P F + +Y+ V
Sbjct: 994 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1046
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
E + +GT+VG ++ A N + Y I +GNEE F + G + V LD E
Sbjct: 1047 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1101
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
+ V+A S L + + +V + ++D N+ PP F K Y GV+
Sbjct: 1102 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1155
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
DA++ + +++V A D D GN YS++A +R + ++ + F + + G+++T
Sbjct: 1156 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1207
Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
LF YF ++A D L+G D + + L D +V IV N P V
Sbjct: 1208 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1264
Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
E+ +L I GA +V + + H D ++ + +L ++ ++ TNR +D +
Sbjct: 1265 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1324
Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
+ + +D + F+ Y +L+++ +V + + + + A++ LA ++
Sbjct: 1325 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1384
Query: 3077 FLA---AMLFVLMNWYYRTVHKRKLKAIVA 3103
L A+L VL+++ R K I A
Sbjct: 1385 ILCCIPAILVVLVSYRQRQAECTKTARIQA 1414
Score = 280 bits (716), Expect = 2e-74
Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)
Query: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 39 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94
Query: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 95 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149
Query: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207
Query: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 208 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263
Query: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
+F +PL Y ++ E N + T + + D + + +
Sbjct: 264 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323
Query: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 324 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
+LD N+ P F +Y G + E+ P ++T +R+ A D+D +
Sbjct: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
Query: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
+ + S F ++ +++ +P+D E+ +T + P V V I+
Sbjct: 444 F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498
Query: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y + Q
Sbjct: 499 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555
Query: 719 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
F IN +G IT ++ Y L V+A D ++ I TV I +L N+ P
Sbjct: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
+ Y + + E + + + A D E ++ Y+I+ P + ++L+ TTG I T
Sbjct: 616 FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
LDRE+ D R I++ GRP TS+ATV + + D+NDN P F LP
Sbjct: 672 LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722
Query: 895 FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
V+E A + QV A D D G+NG V Y + G F I +S+G + T +L+
Sbjct: 723 RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778
Query: 955 RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
RE Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++P +
Sbjct: 779 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838
Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
+ + D D+G N +SY I V F++ + + LD E A+ ++
Sbjct: 839 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
EA D G G ATV V V D+ND P+F + Y+ V D +G I + A DAD
Sbjct: 897 EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
RV YR + + F + +G ++ L+ E + L+V A++
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013
Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
M SS V + V E P FTQ++Y + E A GT V V+ A + +
Sbjct: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068
Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
Y I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
+ K F ++ TG+I L + ++ V+A DD G + V ++V+++ D
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 275 bits (703), Expect = 6e-73
Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 191 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
L V +LD +D P+ P Y ++ E + ++
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364
Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482
Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 483 AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A D P
Sbjct: 536 ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592
Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
+S V I VL N+ P L ++ ISE V + + ++ A+D + +T
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649
Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A +
Sbjct: 650 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704
Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
I ++D NDN P+F + + A + G + A D D I V Y L G
Sbjct: 705 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759
Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
+ LF I S+ + T V ++RE EL+++A D + +ST L I +LD +D
Sbjct: 760 NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
N P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F +H TG
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872
Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
++R + +++ S V A D GT+P G A VT+++ D+ND P F I
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
V A GT I + A D D ++ Y + DD P F V
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983
Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
++G V+ + +N E +++ + D+ V ++ TV +L ++ P+F
Sbjct: 984 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036
Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
Y + E AT GT + ++A +N + Y+++ + + + G +
Sbjct: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089
Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
N +DYE V + V ++ P ++ VY+EI D N++ P+F + Y
Sbjct: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149
Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
V ED + T +L V ATD D+GN++++ Y L +G+ F + TG I
Sbjct: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
++ ++ +A D+ G S + + V VV Q+
Sbjct: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Score = 274 bits (700), Expect = 1e-72
Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)
Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157
Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
+Y+AAI E L IV +ID I Y T
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
S I E PVG ++ + A D D L + F +
Sbjct: 398 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 457 TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512
Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571
Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
++ Y L D P ++ VY+ ++ N+ +P F Q Y + + E
Sbjct: 572 EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629
Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
+ L+ +QA D + ++TYAI G+ F + G++T K LD E S RY
Sbjct: 630 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685
Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
LI+TA+D P TST TV + V D+NDN P F V E + V A
Sbjct: 686 LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741
Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D +
Sbjct: 742 TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796
Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++
Sbjct: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854
Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
I + + F ++ TG +++ R LD E P+ + +I+ + P IA
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
+ + + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y
Sbjct: 911 -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965
Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
++ Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A
Sbjct: 966 RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021
Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
+ I +L + P F+ E PP S L T + +N +VY I +
Sbjct: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073
Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
G +D F I+ +TGVI V N +D E + SY L V A V S TA V I
Sbjct: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
I D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191
Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
++ F V TG + M +S +++AT + + A L V
Sbjct: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240
Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
SV N + V V +V + K +T ++R ++ PG ++
Sbjct: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285
Score = 223 bits (568), Expect = 2e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 390 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 566 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 624 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 681 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 733 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 781 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 840 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
Query: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 958 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013
Query: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069
Query: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239
Query: 878 VNLLDLNDNDPTFQNLP 894
V++++ D N+P
Sbjct: 1240 VSVVNQLDMQVIVSNVP 1256
Score = 89.0 bits (219), Expect = 7e-17
Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)
Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
P+ A+ E+ GTI++ + G IE SL D + + + L+S
Sbjct: 40 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
R L +D P ++ S N++ ++ +V I V D ND P F
Sbjct: 100 GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150
Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
+ +V E P GT++ T ATD D+GPNG++ Y ++ + F + M
Sbjct: 151 SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210
Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
+G + ++ L +K + + + A D + TT L V+V+D +D P+F V
Sbjct: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
PN I +R L + + A D+D + + YS L
Sbjct: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
FF + P + + + ++R+ + L++ A D G P+P L + + D
Sbjct: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388
Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
++ P F P S Q +L E +P G + N+T A+D D
Sbjct: 389 NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442
Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
+ + F + G L +L+ +DRE + ++F + A D V
Sbjct: 443 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487
Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
+ V + + D ND P F + Y V TD + G +IQ+ A+DAD G+N + Y
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2885 IL 2886
IL
Sbjct: 548 IL 549
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 290 bits (743), Expect = 1e-77
Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
Query: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 308 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 367 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 477
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 478 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
Query: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 537 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 596
Query: 543 TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
+ V I VL N+ + P F + Y + E L+ L+ATD + + ITY+I
Sbjct: 597 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 653
Query: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
+ + +L E G++++ + LD E Y+ ++ G P ST V I V
Sbjct: 654 NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 707
Query: 662 FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
D NDN P F Y +SVVE A A V + ATD D GQ + YSL +
Sbjct: 708 TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 761
Query: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+DN P
Sbjct: 762 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 818
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
+ ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ TG++
Sbjct: 819 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 876
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
+ LD E EA + + PP ATV V + D+ND P F +
Sbjct: 877 LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 931
Query: 896 VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
V G I V A D D GL V YR + P F + SG V+T
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 991
Query: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
L+ E ++L VVA D G P SS++T+ I VL E P F Y ++
Sbjct: 992 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1050
Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
+ +V + + +N + Y I GN + F + V+ LD ET +Y+L +
Sbjct: 1051 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1107
Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
+A + N V + + TA V++ + D N++ P+F + Y V ED S+L++
Sbjct: 1108 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1166
Query: 1125 KATDADEGEFGRVWYRIL 1142
KATD D G + + YR++
Sbjct: 1167 KATDKDTGNYSVMAYRLI 1184
Score = 284 bits (727), Expect = 9e-76
Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 192
Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 193 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 252
Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 253 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 312
Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
I ++ L+G F ++ T +++ V D F ++ +
Sbjct: 313 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 369
Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++ A
Sbjct: 370 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 429
Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
D+D + + TG+ R +DREEQ++Y ++ A D V
Sbjct: 430 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 487
Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
S IV I + D ND+ P F V V PG + +TA+D D N ++ Y
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
I LV Q D F +N TG + + + + TY +T+ DNA ER
Sbjct: 548 I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 594
Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
S+ + + VL N+ +P P + Y +E I E G L+ + A D +
Sbjct: 595 RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 647
Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
+TY + + P L +++ G + + +D E + ASD G P + V +
Sbjct: 648 ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 705
Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
+ D+NDN P+FD + + + V ATD D+G + YSLG+ + F I
Sbjct: 706 VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 765
Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
+ G IY L+RE +D+Y L +A D A + R +++ + I+VLD++D P F+
Sbjct: 766 T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 820
Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
++ V EN PAGT+++ + A D D G N ++Y + P V+ F + +G ++ R
Sbjct: 821 NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 878
Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
L YE F + V A D G PP G + V V D+ND PVF + +
Sbjct: 879 SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 934
Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ + + + VYA D D GL + VRY F ++ SG + T
Sbjct: 935 -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 993
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
L+ E ++ L++VA D G+PV + + L P F + +Y+ V
Sbjct: 994 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1046
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
E + +GT+VG ++ A N + Y I +GNEE F + G + V LD E
Sbjct: 1047 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1101
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
+ V+A S L + + +V + ++D N+ PP F K Y GV+
Sbjct: 1102 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1155
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
DA++ + +++V A D D GN YS++A +R + ++ + F + + G+++T
Sbjct: 1156 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1207
Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
LF YF ++A D L+G D + + L D +V IV N P V
Sbjct: 1208 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1264
Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
E+ +L I GA +V + + H D ++ + +L ++ ++ TNR +D +
Sbjct: 1265 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1324
Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
+ + +D + F+ Y +L+++ +V + + + + A++ LA ++
Sbjct: 1325 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1384
Query: 3077 FLA---AMLFVLMNW 3088
L A+L VL+++
Sbjct: 1385 ILCCIPAILVVLVSY 1399
Score = 280 bits (716), Expect = 2e-74
Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)
Query: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 39 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94
Query: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 95 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149
Query: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207
Query: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 208 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263
Query: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
+F +PL Y ++ E N + T + + D + + +
Sbjct: 264 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323
Query: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 324 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
+LD N+ P F +Y G + E+ P ++T +R+ A D+D +
Sbjct: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
Query: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
+ + S F ++ +++ +P+D E+ +T + P V V I+
Sbjct: 444 F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498
Query: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y + Q
Sbjct: 499 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555
Query: 719 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
F IN +G IT ++ Y L V+A D ++ I TV I +L N+ P
Sbjct: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 615
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
+ Y + + E + + + A D E ++ Y+I+ P + ++L+ TTG I T
Sbjct: 616 FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 671
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
LDRE+ D R I++ GRP TS+ATV + + D+NDN P F LP
Sbjct: 672 LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 722
Query: 895 FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
V+E A + QV A D D G+NG V Y + G F I +S+G + T +L+
Sbjct: 723 RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 778
Query: 955 RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
RE Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++P +
Sbjct: 779 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 838
Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
+ + D D+G N +SY I V F++ + + LD E A+ ++
Sbjct: 839 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 896
Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
EA D G G ATV V V D+ND P+F + Y+ V D +G I + A DAD
Sbjct: 897 EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 954
Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
RV YR + + F + +G ++ L+ E + L+V A++
Sbjct: 955 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1013
Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
M SS V + V E P FTQ++Y + E A GT V V+ A + +
Sbjct: 1014 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1068
Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
Y I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 1069 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
+ K F ++ TG+I L + ++ V+A DD G + V ++V+++ D
Sbjct: 1189 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1247
Score = 275 bits (703), Expect = 6e-73
Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 191 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
L V +LD +D P+ P Y ++ E + ++
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 364
Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482
Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 483 AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A D P
Sbjct: 536 ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 592
Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
+S V I VL N+ P L ++ ISE V + + ++ A+D + +T
Sbjct: 593 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 649
Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A +
Sbjct: 650 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 704
Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
I ++D NDN P+F + + A + G + A D D I V Y L G
Sbjct: 705 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 759
Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
+ LF I S+ + T V ++RE EL+++A D + +ST L I +LD +D
Sbjct: 760 NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 814
Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
N P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F +H TG
Sbjct: 815 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 872
Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
++R + +++ S V A D GT+P G A VT+++ D+ND P F I
Sbjct: 873 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 931
Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
V A GT I + A D D ++ Y + DD P F V
Sbjct: 932 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 983
Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
++G V+ + +N E +++ + D+ V ++ TV +L ++ P+F
Sbjct: 984 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1036
Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
Y + E AT GT + ++A +N + Y+++ + + + G +
Sbjct: 1037 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1089
Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
N +DYE V + V ++ P ++ VY+EI D N++ P+F + Y
Sbjct: 1090 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1149
Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
V ED + T +L V ATD D+GN++++ Y L +G+ F + TG I
Sbjct: 1150 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1209
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
++ ++ +A D+ G S + + V VV Q+
Sbjct: 1210 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1246
Score = 274 bits (700), Expect = 1e-72
Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)
Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 101 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 157
Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 158 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 217
Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 218 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 277
Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
+Y+AAI E L IV +ID I Y T
Sbjct: 278 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 337
Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 338 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 397
Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
S I E PVG ++ + A D D L + F +
Sbjct: 398 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 456
Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 457 TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 512
Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 513 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 571
Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
++ Y L D P ++ VY+ ++ N+ +P F Q Y + + E
Sbjct: 572 EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 629
Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
+ L+ +QA D + ++TYAI G+ F + G++T K LD E S RY
Sbjct: 630 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 685
Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
LI+TA+D P TST TV + V D+NDN P F V E + V A
Sbjct: 686 LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 741
Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D +
Sbjct: 742 TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 796
Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++
Sbjct: 797 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 854
Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
I + + F ++ TG +++ R LD E P+ + +I+ + P IA
Sbjct: 855 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 910
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
+ + + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y
Sbjct: 911 -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 965
Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
++ Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A
Sbjct: 966 RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1021
Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
+ I +L + P F+ E PP S L T + +N +VY I +
Sbjct: 1022 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1073
Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
G +D F I+ +TGVI V N +D E + SY L V A V S TA V I
Sbjct: 1074 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1132
Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
I D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 1133 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1191
Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
++ F V TG + M +S +++AT + + A L V
Sbjct: 1192 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1240
Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
SV N + V V +V + K +T ++R ++ PG ++
Sbjct: 1241 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1285
Score = 223 bits (568), Expect = 2e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 390 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 566 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 624 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 680
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 681 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 732
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 733 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 780
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 781 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 839
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 840 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 897
Query: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 898 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 957
Query: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 958 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1013
Query: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 1014 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1069
Query: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 1070 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1128
Query: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 1129 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1188
Query: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 1189 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1239
Query: 878 VNLLDLNDNDPTFQNLP 894
V++++ D N+P
Sbjct: 1240 VSVVNQLDMQVIVSNVP 1256
Score = 89.0 bits (219), Expect = 7e-17
Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)
Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
P+ A+ E+ GTI++ + G IE SL D + + + L+S
Sbjct: 40 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
R L +D P ++ S N++ ++ +V I V D ND P F
Sbjct: 100 GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150
Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
+ +V E P GT++ T ATD D+GPNG++ Y ++ + F + M
Sbjct: 151 SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210
Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
+G + ++ L +K + + + A D + TT L V+V+D +D P+F V
Sbjct: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
PN I +R L + + A D+D + + YS L
Sbjct: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
FF + P + + + ++R+ + L++ A D G P+P L + + D
Sbjct: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388
Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
++ P F P S Q +L E +P G + N+T A+D D
Sbjct: 389 NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442
Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
+ + F + G L +L+ +DRE + ++F + A D V
Sbjct: 443 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487
Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
+ V + + D ND P F + Y V TD + G +IQ+ A+DAD G+N + Y
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2885 IL 2886
IL
Sbjct: 548 IL 549
>gi|218505775 protocadherin 15 isoform CD1-1 precursor [Homo sapiens]
Length = 1962
Score = 290 bits (743), Expect = 1e-77
Identities = 315/1098 (28%), Positives = 486/1098 (44%), Gaps = 109/1098 (9%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIV-----NATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 133 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 192
Query: 168 LYSFQ------PPSQFFAID-SARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q + F I G + + + L+YE Y + + A D Q+ +T
Sbjct: 193 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 252
Query: 219 LANLAIIITDVQDMDPIFIN------------LPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 253 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 312
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 313 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 371
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 372 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 427
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 428 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITRY----LTLLQPVDREEQQTY 482
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 483 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 541
Query: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGG----GEE 542
D G+ GE++Y F ++K TGLI + ++ + + + LT+ A D
Sbjct: 542 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRN 601
Query: 543 TTGRVRINVLDVND-NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIV 601
+ V I VL N+ + P F + Y + E L+ L+ATD + + ITY+I
Sbjct: 602 SICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDRE---GDSITYAIE 658
Query: 602 SASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
+ + +L E G++++ + LD E Y+ ++ G P ST V I V
Sbjct: 659 NGDPQRVF---NLSETTGILTLGKALDRESTDR---YILIITASDGRPDGTSTATVNIVV 712
Query: 662 FDENDNPPTFSKPAYF---VSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEG-ST 717
D NDN P F Y +SVVE A A V + ATD D GQ + YSL +
Sbjct: 713 TDVNDNAPVFD--PYLPRNLSVVEE-EANAFVGQVKATDPDAGIN-GQ--VHYSLGNFNN 766
Query: 718 QFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT 777
FRI + +G I T L+RE + Y L+V A DG V T T+ I +LDI+DN P
Sbjct: 767 LFRITS-NGSIYTAVKLNREVRDYYELVVVATDGAVHPRHST--LTLAIKVLDIDDNSPV 823
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQPP--NKFYSLNSTTGKIRT 835
+ ++ Y + + E P + + + A D DLG N + Y I+ P F++L+ TG++
Sbjct: 824 FTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSL 881
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPF 895
+ LD E EA + + PP ATV V + D+ND P F +
Sbjct: 882 LRS-LDYEAFPDQEASITFLVEAFDIYGTMPP----GIATVTVIVKDMNDYPPVFSKRIY 936
Query: 896 VAEVLEGIPAGVSIYQVVAIDLD-EGL-NGLVSYR---MPVGMPRMDFLINSSSGVVVTT 950
V G I V A D D GL V YR + P F + SG V+T
Sbjct: 937 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITR 996
Query: 951 TELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPR 1010
L+ E ++L VVA D G P SS++T+ I VL E P F Y ++
Sbjct: 997 VNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPG-EIPRFTQEEYRPPPVSELAT 1055
Query: 1011 EFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYMLIL 1070
+ +V + + +N + Y I GN + F + V+ LD ET +Y+L +
Sbjct: 1056 KGTMVGV---ISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1112
Query: 1071 EA------IDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQL 1124
+A + N V + + TA V++ + D N++ P+F + Y V ED S+L++
Sbjct: 1113 QADSLEVVLANLRVPSK-SNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRV 1171
Query: 1125 KATDADEGEFGRVWYRIL 1142
KATD D G + + YR++
Sbjct: 1172 KATDKDTGNYSVMAYRLI 1189
Score = 284 bits (727), Expect = 9e-76
Identities = 342/1335 (25%), Positives = 580/1335 (43%), Gaps = 151/1335 (11%)
Query: 1837 VGIRVLDINDNDPVLLNLPMNITISENSPVSS-----FVAHVLASDADSGCNARLTFNIT 1891
V I V D NDN P + T++E +PV + F A+D D G N ++ + I
Sbjct: 138 VRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQ 197
Query: 1892 AG-----NRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLL 1946
+ + TG + + + L+ E Y + I D +N R L
Sbjct: 198 YNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLT 257
Query: 1947 IFLSDENDNHPLFTKS------------TYQAEVME-NSPAGTPLTVLNGPILALDADQD 1993
+ + D +D P+F TYQA + E +P ++ PI A+D D++
Sbjct: 258 VDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRN 317
Query: 1994 IY------AVVTYQLLGAQSG---LFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAE 2044
I ++ L+G F ++ T +++ V D F ++ +
Sbjct: 318 IQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRD---FHQKFDLVIKAEQ 374
Query: 2045 DIGL-LNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSV---------LQVTAT 2094
D G L + A L I ILD+N+ P F+ + ++LE+ P G ++ L++ A
Sbjct: 375 DNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVAL 434
Query: 2095 DEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNAT--IDREEQESYRLTVVATDRGTV 2152
D+D + + TG+ R +DREEQ++Y ++ A D V
Sbjct: 435 DKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG--V 492
Query: 2153 PLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHD--LNPKLEYH 2210
S IV I + D ND+ P F V V PG + +TA+D D N ++ Y
Sbjct: 493 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 552
Query: 2211 IVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPER 2270
I LV Q D F +N TG + + + + TY +T+ DNA ER
Sbjct: 553 I-----------LVGAQGD-FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPA-ER 599
Query: 2271 SVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGL 2330
S+ + + VL N+ +P P + Y +E I E G L+ + A D +
Sbjct: 600 RNSI--CTVYIEVLPPNNQSPPRFP-QLMYSLE-ISEAMRVGAVLLNLQATDRE---GDS 652
Query: 2331 VTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYL 2390
+TY + + P L +++ G + + +D E + ASD G P + V +
Sbjct: 653 ITYAIENGDPQRVFNLSETT-GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNI 710
Query: 2391 EIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAI 2450
+ D+NDN P+FD + + + V ATD D+G + YSLG+ + F I
Sbjct: 711 VVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNLFRI 770
Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFS 2510
+ G IY L+RE +D+Y L +A D A + R +++ + I+VLD++D P F+
Sbjct: 771 T-SNGSIYTAVKLNREVRDYYELVVVATDG----AVHPRHSTLTLAIKVLDIDDNSPVFT 825
Query: 2511 KPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQR 2569
++ V EN PAGT+++ + A D D G N ++Y + P V+ F + +G ++ R
Sbjct: 826 NSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLR 883
Query: 2570 PLQSYEKF-------SLTVVATD--GGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTIL 2620
L YE F + V A D G PP G + V V D+ND PVF + +
Sbjct: 884 SLD-YEAFPDQEASITFLVEAFDIYGTMPP--GIATVTVIVKDMNDYPPVFSKRIYKGM- 939
Query: 2621 HIREEIPLRSNVYEVYATDKDE-GLNGA-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQR 2678
+ + + + VYA D D GL + VRY F ++ SG + T
Sbjct: 940 -VAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN 998
Query: 2679 LDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVP 2738
L+ E ++ L++VA D G+PV + + L P F + +Y+ V
Sbjct: 999 LNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHP--GEIPRFTQE-----EYRPPPVS 1051
Query: 2739 EHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP-DGCLLVLRDLDREREA 2797
E + +GT+VG ++ A N + Y I +GNEE F + G + V LD E
Sbjct: 1052 ELATKGTMVGVISAAAI-----NQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRT 1106
Query: 2798 IFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVAT 2857
+ V+A S L + + +V + ++D N+ PP F K Y GV+
Sbjct: 1107 SYVLRVQADSLEVVLA------NLRVPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSE 1160
Query: 2858 DAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTF 2917
DA++ + +++V A D D GN YS++A +R + ++ + F + + G+++T
Sbjct: 1161 DARMFTSVLRVKATDKDTGN-----YSVMA---YRLIIPPIKEGKEGFVVETYTGLIKTA 1212
Query: 2918 DLFMAYSPGYFVVDIVARD-----LAGHNDTAIIGIYILRDDQRVKIVINEIPDRVRGFE 2972
LF YF ++A D L+G D + + L D +V IV N P V
Sbjct: 1213 MLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL--DMQV-IVSNVPPTLVEKKI 1269
Query: 2973 EEFIHLL-----SNITGA--IVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRILDVD 3025
E+ +L I GA +V + + H D ++ + +L ++ ++ TNR +D +
Sbjct: 1270 EDLTEILDRYVQEQIPGAKVVVESIGARRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRN 1329
Query: 3026 RVIQMIDENKEQLRNLFRNY-----NVLDVQPAISV----RLPDDMSALQMAIIVLAILL 3076
+ + +D + F+ Y +L+++ +V + + + + A++ LA ++
Sbjct: 1330 ELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFII 1389
Query: 3077 FLA---AMLFVLMNW 3088
L A+L VL+++
Sbjct: 1390 ILCCIPAILVVLVSY 1404
Score = 280 bits (716), Expect = 2e-74
Identities = 337/1259 (26%), Positives = 534/1259 (42%), Gaps = 145/1259 (11%)
Query: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 44 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 99
Query: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 100 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 154
Query: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 155 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 212
Query: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 213 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 268
Query: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
+F +PL Y ++ E N + T + + D + + +
Sbjct: 269 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 328
Query: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 329 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 388
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
+LD N+ P F +Y G + E+ P ++T +R+ A D+D +
Sbjct: 389 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 448
Query: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
+ + S F ++ +++ +P+D E+ +T + P V V I+
Sbjct: 449 F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 503
Query: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y + Q
Sbjct: 504 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 560
Query: 719 FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPT- 777
F IN +G IT ++ Y L V+A D ++ I TV I +L N+ P
Sbjct: 561 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPR 620
Query: 778 WKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYSIQ--PPNKFYSLNSTTGKIRT 835
+ Y + + E + + + A D E ++ Y+I+ P + ++L+ TTG I T
Sbjct: 621 FPQLMYSLEISEAMRVGAVLLNLQATDR---EGDSITYAIENGDPQRVFNLSETTG-ILT 676
Query: 836 THAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LP 894
LDRE+ D R I++ GRP TS+ATV + + D+NDN P F LP
Sbjct: 677 LGKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLP 727
Query: 895 FVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELD 954
V+E A + QV A D D G+NG V Y + G F I +S+G + T +L+
Sbjct: 728 RNLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLN 783
Query: 955 RERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRV 1014
RE Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++P +
Sbjct: 784 REVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI 843
Query: 1015 VWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLIL 1070
+ + D D+G N +SY I V F++ + + LD E A+ ++
Sbjct: 844 LQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLV 901
Query: 1071 EAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDAD 1130
EA D G G ATV V V D+ND P+F + Y+ V D +G I + A DAD
Sbjct: 902 EAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDAD 959
Query: 1131 EGEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDL 1185
RV YR + + F + +G ++ L+ E + L+V A++
Sbjct: 960 PPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGE 1018
Query: 1186 GPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVN 1245
M SS V + V E P FTQ++Y + E A GT V V+ A + +
Sbjct: 1019 PVMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IV 1073
Query: 1246 YRILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFC 1297
Y I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 1074 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1133
Query: 1298 SVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTS 1355
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1193
Query: 1356 TQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
+ K F ++ TG+I L + ++ V+A DD G + V ++V+++ D
Sbjct: 1194 KEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1252
Score = 275 bits (703), Expect = 6e-73
Identities = 317/1177 (26%), Positives = 516/1177 (43%), Gaps = 142/1177 (12%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATV-----KAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 137 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 195
Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 196 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 250
Query: 1508 KKDHILQVTILDINDNPPVIES-----------PFGYNVSVNE-----NVGGGTAVVQVR 1551
L V +LD +D P+ P Y ++ E + ++
Sbjct: 251 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 310
Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 311 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLE-PVNRDFHQKFDLV 369
Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 370 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 429
Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 430 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 487
Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 488 AFDG-------VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 540
Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPP 1830
D G NG++ Y I+ G G+F+I+ G++ + VE+ Y LT+ A D P
Sbjct: 541 ADEGSNGEITYEILVGAQ-GDFIINKTTGLITIAPGVEMIVGRT--YALTVQAADNAPPA 597
Query: 1831 --LSSTMLVGIRVLDINDNDPVLL-NLPMNITISENSPVSSFVAHVLASDADSGCNARLT 1887
+S V I VL N+ P L ++ ISE V + + ++ A+D + +T
Sbjct: 598 ERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAMRVGAVLLNLQATDREGDS---IT 654
Query: 1888 FNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDN-PENPRIARRDYDLLL 1946
+ I G+ +R F ++ TTGI+T+ + LDRE Y L I+ D P+ A +
Sbjct: 655 YAIENGDPQRVFNLSETTGILTLGKALDRESTDRYILIITASDGRPDGTSTATVN----- 709
Query: 1947 IFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQ 2006
I ++D NDN P+F + + A + G + A D D I V Y L G
Sbjct: 710 IVVTDVNDNAPVFDPYLPRNLSVVEEEANAFV----GQVKATDPDAGINGQVHYSL-GNF 764
Query: 2007 SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAED--IGLLNSTAHLLITILDDND 2064
+ LF I S+ + T V ++RE EL+++A D + +ST L I +LD +D
Sbjct: 765 NNLFRITSNGSIYTA---VKLNREVRD--YYELVVVATDGAVHPRHSTLTLAIKVLDIDD 819
Query: 2065 NRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFL-IHLVTG 2123
N P F+ +T TV + EN P G ++LQ+ A D D G N + YRI + F +H TG
Sbjct: 820 NSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTG 877
Query: 2124 ---VIRVGNATIDREEQESYRLTVVATD-RGTVPLSGTAIVTILIDDINDSRPEFLNPIQ 2179
++R + +++ S V A D GT+P G A VT+++ D+ND P F I
Sbjct: 878 ELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMP-PGIATVTVIVKDMNDYPPVFSKRIY 936
Query: 2180 TVSVLESAEPGTVIANITAIDHDLN----PKLEYHIVGIVAKDDTDRLVPNQEDAFAVNI 2235
V A GT I + A D D ++ Y + DD P F V
Sbjct: 937 KGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRV------DDVQ--FPYPASIFEVEE 988
Query: 2236 NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNT-PQFK 2294
++G V+ + +N E +++ + D+ V ++ TV +L ++ P+F
Sbjct: 989 DSGRVITRVNLNEEPTTIFKLVVVAFDDGEP-------VMSSSATVKILVLHPGEIPRFT 1041
Query: 2295 PFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKV 2354
Y + E AT GT + ++A +N + Y+++ + + + G +
Sbjct: 1042 QE--EYRPPPVSELATKGTMVGVISAA----AINQSIVYSIVSGNEEDTFGINNIT-GVI 1094
Query: 2355 IANRTVDYE-------EVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSY 2407
N +DYE V + V ++ P ++ VY+EI D N++ P+F + Y
Sbjct: 1095 YVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQKKFY 1154
Query: 2408 QEAVFEDVPVGTIILTVTATDADSGNFALIEYSL-----GDGESKFAINPTTGDIYVLSS 2462
V ED + T +L V ATD D+GN++++ Y L +G+ F + TG I
Sbjct: 1155 IGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAML 1214
Query: 2463 LDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQV 2499
++ ++ +A D+ G S + + V VV Q+
Sbjct: 1215 FHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQL 1251
Score = 274 bits (700), Expect = 1e-72
Identities = 334/1245 (26%), Positives = 533/1245 (42%), Gaps = 152/1245 (12%)
Query: 1164 RPLDRE---RNSSHVLIVEAYNHDLGPM-RSSVRVIVYVEDINDEAPVFTQQQYSRLGLR 1219
R LDR+ S V+ V+ N +G + VR++V D ND +P F + Y +
Sbjct: 106 RVLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVV--RDRNDNSPTFKHESYYAT-VN 162
Query: 1220 ETAGIGTSVIVV-----QATDRDSGDGGLVNYRILSGAEGK-----FEIDES-TGLIITV 1268
E +GT++ ATD D G G + Y I + FEI TG I+
Sbjct: 163 ELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLMLTGNIVLR 222
Query: 1269 NYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELD---------EAVQFSNA--- 1316
L+YE KT Y + + A D+A N+ + ++ LD V N
Sbjct: 223 KRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDC 282
Query: 1317 ---SYEAAILENLA---LGTEIVRVQAYSIDNLNQIT---------YRFNAYTSTQAKAL 1361
+Y+AAI E L IV +ID I Y T
Sbjct: 283 RPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRF 342
Query: 1362 FKIDAITGVITVQGLVDREKGDFYTLTVVAD-DGGPKVDSTVKVYITVLDENDNSPRFDF 1420
F + T +++ V+R+ + L + A+ D G + + ++I +LDEN+ SP F
Sbjct: 343 FHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHIEILDENNQSPYFTM 402
Query: 1421 TSDSAVSIPEDCPVGQRVAT---------VKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
S I E PVG ++ + A D D L + F +
Sbjct: 403 PSYQGY-ILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ 461
Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
T + + + +P+DREE Y + A D + I+ + ++D NDN P
Sbjct: 462 TGIT-RYLTLLQPVDREEQQTYTFSITAFDG--VQESEPVIVNIQVMDANDNTPTFPE-I 517
Query: 1532 GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAP 1591
Y+V V ++ G +V+Q+ A D D G N ++Y I G + F +++ +G I P
Sbjct: 518 SYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQG-DFIINKTTGLITIAPGV 576
Query: 1592 PDRERQSFYHLVATVEDEGTPT--LSATTHVYVTIVDENDNAP-MFQQPHYEVLLDEGPD 1648
++ Y L D P ++ VY+ ++ N+ +P F Q Y + + E
Sbjct: 577 EMIVGRT-YALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSLEISEAM- 634
Query: 1649 TLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYT 1708
+ L+ +QA D + ++TYAI G+ F + G++T K LD E S RY
Sbjct: 635 RVGAVLLNLQATDRE---GDSITYAIENGDPQRVFNLSETTGILTLGKALDRE-STDRYI 690
Query: 1709 LIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLA 1768
LI+TA+D P TST TV + V D+NDN P F V E + V A
Sbjct: 691 LIITASDGRP----DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVKA 746
Query: 1769 HDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGM 1828
D D+G NGQV YS+ + + L F I+ + V+L+RE +Y L + A D +
Sbjct: 747 TDPDAGINGQVHYSLGNFNNL--FRITSNGSIYTA---VKLNREVRDYYELVVVATDGAV 801
Query: 1829 PPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTF 1888
P ST+ + I+VLDI+DN PV N + + EN P + + + A D D G N +++
Sbjct: 802 HPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN--VSY 859
Query: 1889 NITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPEN------PRIARRDY 1942
I + + F ++ TG +++ R LD E P+ + +I+ + P IA
Sbjct: 860 RIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA---- 915
Query: 1943 DLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAV--VTY 2000
+ + + D ND P+F+K Y+ V ++ GTP+T + A DAD V Y
Sbjct: 916 -TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITT----VYAEDADPPGLPASRVRY 970
Query: 2001 QLLGAQ----SGLFDINSSTGVVTVRSGVIIDREAFSPPILELLLLAEDIG--LLNSTAH 2054
++ Q + +F++ +G V R V ++ E + I +L+++A D G +++S+A
Sbjct: 971 RVDDVQFPYPASIFEVEEDSGRVITR--VNLNEEPTT--IFKLVVVAFDDGEPVMSSSAT 1026
Query: 2055 LLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTAT----DEDSGLNGELVYRIEA 2110
+ I +L + P F+ E PP S L T + +N +VY I +
Sbjct: 1027 VKILVLHPGE-IPRFTQE-------EYRPPPVSELATKGTMVGVISAAAINQSIVYSIVS 1078
Query: 2111 G-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTV-------PLSGTAIVTI 2162
G +D F I+ +TGVI V N +D E + SY L V A V S TA V I
Sbjct: 1079 GNEEDTFGINNITGVIYV-NGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYI 1137
Query: 2163 LIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLN--PKLEYHIVGIVAKDDT 2220
I D N+ P F V E A T + + A D D + Y ++ K+
Sbjct: 1138 EIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEG- 1196
Query: 2221 DRLVPNQEDAFAVNINTGSV--------MVKSPMNRELVATYEVTLSVIDNASDLPERSV 2272
++ F V TG + M +S +++AT + + A L V
Sbjct: 1197 -------KEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVL----V 1245
Query: 2273 SVPN-AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLI 2316
SV N + V V +V + K +T ++R ++ PG ++
Sbjct: 1246 SVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVV 1290
Score = 223 bits (568), Expect = 2e-57
Identities = 254/917 (27%), Positives = 404/917 (44%), Gaps = 98/917 (10%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 395 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 452
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 453 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 510
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 511 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 570
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV----QDMDPIFINLPYST 243
T+ ++ + Y LTV A D P ++ + +V P F L YS
Sbjct: 571 TIAPGVEMIVGRTYALTVQAA--DNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 628
Query: 244 NIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDREN 303
I E G + + A D++ I Y I +G+ +F L +G+LTL LDRE+
Sbjct: 629 EISEAMRVGAVLLNLQATDREGD---SITYAIENGDPQRVFNLSETTGILTLGKALDRES 685
Query: 304 PLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS-SEYSVAITELAQ 362
+ +IL + + D P D T T T NI+V D+NDNAP F+ ++++ E
Sbjct: 686 ---TDRYILIITAS----DGRP-DGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 737
Query: 363 VGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYE 422
F QV D + G+N Y +GN ++ F I+ I A+ L+ E
Sbjct: 738 NAFV----GQVKATDPDAGINGQVH-YSLGNFNNLFRITSNG-------SIYTAVKLNRE 785
Query: 423 TVDRYDFDLFANESV--PDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVL 480
D Y+ + A + P H + I +++ +DN P+F+ Y + + EN+ GT++L
Sbjct: 786 VRDYYELVVVATDGAVHPRH-STLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 844
Query: 481 TVLATDNDAGTFGEVSYFFSDDPDR--FSLDKDTGLIMLIARLDYELI----QRFTLTII 534
+ A D D G VSY + F+L TG + L+ LDYE T +
Sbjct: 845 QIEAKDVDLG--ANVSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 902
Query: 535 ARDGGGEETTGRVRINVL--DVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDEDSP- 591
A D G G + V+ D+ND P F K Y G + + T + + A D D P
Sbjct: 903 AFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPG 962
Query: 592 -PNNQITYSI--VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGN 648
P +++ Y + V S F++ G + V+ L+ E + + L V+A D G
Sbjct: 963 LPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN--LNEEPTT--IFKLVVVAFDDGE 1018
Query: 649 PPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMA-GATVLFLNATDLDRSREYGQE 707
P ++S+ V I V + P F++ Y V + G V ++A +++S Y
Sbjct: 1019 PVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQSIVY--- 1074
Query: 708 SIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA-----VDGGVGHNQKTGIA 762
SI+ E T F IN +G I LD ET++ Y+L V+A V + K+ A
Sbjct: 1075 SIVSGNEEDT-FGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTA 1133
Query: 763 TVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVYS-IQPPN 821
V I + D N++ P ++ Y + E + V V A D D G + Y I PP
Sbjct: 1134 KVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPI 1193
Query: 822 K----FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVF 877
K + + + TG I+T AML + V++ D G+ + A V
Sbjct: 1194 KEGKEGFVVETYTGLIKT--AMLFHN----MRRSYFKFQVIATDDYGK---GLSGKADVL 1244
Query: 878 VNLLDLNDNDPTFQNLP 894
V++++ D N+P
Sbjct: 1245 VSVVNQLDMQVIVSNVP 1261
Score = 89.0 bits (219), Expect = 7e-17
Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)
Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
P+ A+ E+ GTI++ + G IE SL D + + + L+S
Sbjct: 45 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 104
Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
R L +D P ++ S N++ ++ +V I V D ND P F
Sbjct: 105 GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 155
Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
+ +V E P GT++ T ATD D+GPNG++ Y ++ + F + M
Sbjct: 156 SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 215
Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
+G + ++ L +K + + + A D + TT L V+V+D +D P+F V
Sbjct: 216 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 275
Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
PN I +R L + + A D+D + + YS L
Sbjct: 276 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 335
Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
FF + P + + + ++R+ + L++ A D G P+P L + + D
Sbjct: 336 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 393
Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
++ P F P S Q +L E +P G + N+T A+D D
Sbjct: 394 NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 447
Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
+ + F + G L +L+ +DRE + ++F + A D V
Sbjct: 448 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 492
Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
+ V + + D ND P F + Y V TD + G +IQ+ A+DAD G+N + Y
Sbjct: 493 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 552
Query: 2885 IL 2886
IL
Sbjct: 553 IL 554
>gi|9966883 protocadherin 9 isoform 2 precursor [Homo sapiens]
Length = 1203
Score = 285 bits (730), Expect = 4e-76
Identities = 241/789 (30%), Positives = 374/789 (47%), Gaps = 70/789 (8%)
Query: 1963 TYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLG--AQSGLFDINSSTGVVT 2020
T + E+ EN P G LN I ++A A + Y+L+ + L ++SSTG +
Sbjct: 29 TIREELPENVPIGNIPKDLN--ISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIF 86
Query: 2021 VRSGVIIDREAFSPPI-----------LELLLLAEDIGLLNSTAHLLITILDDNDNRPTF 2069
S I DRE LE+++L D L + I + D NDN P F
Sbjct: 87 TTSNRI-DREKLCAGASYAEENECFFELEVVILPNDFFRL---IKIKIIVKDTNDNAPMF 142
Query: 2070 SPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIR--- 2126
+ + + EN +ATD D+G NG Y + G Q F + +V
Sbjct: 143 PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG-QSVFGLDIVETPEGEKW 201
Query: 2127 ---VGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
+ +DRE++++Y + + D GT S TAI+ + + D+ND+RP F V +
Sbjct: 202 PQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHI 261
Query: 2184 LESAEPGTVIANITAIDHDLNPKLEY-HIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV 2242
E+A GT + + A D D+ E +I G T RL FA+N TG + V
Sbjct: 262 PENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-------FALNNTTGLITV 314
Query: 2243 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF------KPF 2296
+ ++RE A ++VT+ D +S P R A +T+NV DVNDN P P
Sbjct: 315 QRSLDREETAIHKVTVLASDGSST-PAR------ATVTINVTDVNDNPPNIDLRYIISPI 367
Query: 2297 GITYYMERILEGATPGTTLIAVAAV-DPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355
T Y+ P T IA+ V D D +NG V ++ P +++ + +
Sbjct: 368 NGTVYLSE----KDPVNTKIALITVSDKDTDVNGKVI-CFIEREVPFHLKAVYDNQYLLE 422
Query: 2356 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415
+ +DYE +F + ASD+G P V +++ D NDN PIF+QP + +V E+
Sbjct: 423 TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENN 482
Query: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTA 2475
G + T++ATD DSG A I Y LG S F ++ TG + DRE+++ +I T
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTV 542
Query: 2476 LAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATD 2535
A+DN + ++ V++ VLD ND P+F+ F V EN P ++V + TD
Sbjct: 543 TARDN----GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598
Query: 2536 QDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLT--VVATDGGEPPLWG 2593
D G N +T S+ + F +D SG++ + ++ S T V ATDGG+PP
Sbjct: 599 ADAGENKAVTLSILNDN-DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSS 657
Query: 2594 TTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLR----SNVYEVYATDKDEGLNGAVR 2649
T + + V+DVNDN PV + PP+ T + +PL S V EV+A D D G+N ++
Sbjct: 658 TAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVVAEVFAVDVDTGMNAELK 714
Query: 2650 YSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQ 2709
Y+ + +GN F IDP++G I ++ ++ L++ SDLG P T+ +
Sbjct: 715 YTIV--SGNNK-GLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVF 771
Query: 2710 VALEDIDDN 2718
+ + D N
Sbjct: 772 LYVNDTAGN 780
Score = 255 bits (652), Expect = 5e-67
Identities = 202/683 (29%), Positives = 317/683 (46%), Gaps = 42/683 (6%)
Query: 325 PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
P+D I+V D NDNAP F S +++I E + P+ D + G N
Sbjct: 119 PNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPI---PSATDPDTGFNG 175
Query: 385 MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGY 443
+ L+ S + + +G+ ++ V LD E D Y + + P
Sbjct: 176 VQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSST 235
Query: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD- 502
A +++T+ + NDNRP+F + + + EN VGTSV+ + ATD D G+ E+ Y F
Sbjct: 236 AILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQV 295
Query: 503 ----PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNV 558
F+L+ TGLI + LD E +T++A DG V INV DVNDN
Sbjct: 296 APATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNP 355
Query: 559 PTFQKDAYVGA------LRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDI 612
P + L E +P T++ + +D+D+ N ++ I F
Sbjct: 356 PNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLK--- 412
Query: 613 SLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFS 672
++Y+ ++ S LDYE ++A D+G P LN T V +++ DENDNPP F+
Sbjct: 413 AVYDNQYLLETSSLLDYEGTKE--FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFN 470
Query: 673 KPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQFRINARSGEITTT 731
+P +SV EN G + ++ATD D + I+Y L ++ F ++ ++G +T +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGK---NADIVYQLGPNASFFDLDRKTGVLTAS 527
Query: 732 SLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
+ DRE + +I V A D G Q A V +T+LD NDN P + + + E
Sbjct: 528 RVFDREEQERFIFTVTARDNGTPPLQSQ--AAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 792 PPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851
P S V + D D GEN + SI N + L+ +G I+ ++ DRE + +
Sbjct: 586 PKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIK-SNVSFDREQQSSYTFD 644
Query: 852 LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF----QNLPFVAEVLEGIPAGV 907
V TD G+PP +S+A V +N++D+NDN P N F L IP V
Sbjct: 645 ------VKATDGGQPP--RSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSV 696
Query: 908 SIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA 967
+ +V A+D+D G+N + Y + G + F I+ +G + + + ++L V
Sbjct: 697 -VAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNI 755
Query: 968 SDAGTPTKSSTSTLTIHVLDVND 990
SD G P S TL + L VND
Sbjct: 756 SDLGYP--KSLHTLVLVFLYVND 776
Score = 236 bits (602), Expect = 3e-61
Identities = 189/633 (29%), Positives = 303/633 (47%), Gaps = 45/633 (7%)
Query: 655 VPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE 714
+ + I V D NDN P F P +S+ EN + + +ATD D Q + L
Sbjct: 126 IKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL--LN 183
Query: 715 GSTQFRINA-------RSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNIT 767
G + F ++ + ++ LDRE K Y++ ++ DGG QK+ A + +T
Sbjct: 184 GQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP--QKSSTAILQVT 241
Query: 768 LLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVY----SIQPPNK- 822
+ D+NDN P +K+ +++ E P + V + A D D+G N + Y + P K
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
Query: 823 FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLD 882
++LN+TTG I T LDRE H K+ V +D P + ATV +N+ D
Sbjct: 302 LFALNNTTGLI-TVQRSLDREETAIH------KVTVLASDGSSTPAR----ATVTINVTD 350
Query: 883 LNDNDPTFQNLPFVAEVLEGI-------PAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPR 935
+NDN P +L ++ + G P I + D D +NG V + +P
Sbjct: 351 VNDNPPNI-DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPF 409
Query: 936 MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF 995
+ + ++ T++ LD E E+ ++VASD+G P+ + T+ + + + D ND P F
Sbjct: 410 HLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF 469
Query: 996 FPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTV 1055
V +SVSE+ R + ++ TD D G NA++ Y + G F + + V+
Sbjct: 470 NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTAS 527
Query: 1056 VGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDI 1115
DRE ++ + A DNG + A V VTVLD NDN P F + ++ V E++
Sbjct: 528 RVFDREEQERFIFTVTARDNGTPPLQ--SQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 1116 PEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1175
P+ ++ + TDAD GE V IL+ N +NF + +G++ + DRE+ SS+
Sbjct: 586 PKYSTVGVITVTDADAGENKAVTLSILNDN--DNFVLDPYSGVI-KSNVSFDREQQSSYT 642
Query: 1176 LIVEAYNHDLGPMRSSVRVIVYVEDINDEAP-VFTQQQYSRLGLRETAGIGTSVIV-VQA 1233
V+A + P S+ +V + V D+ND +P V + + L + I SV+ V A
Sbjct: 643 FDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFA 702
Query: 1234 TDRDSGDGGLVNYRILSG-AEGKFEIDESTGLI 1265
D D+G + Y I+SG +G F ID TG I
Sbjct: 703 VDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 233 bits (593), Expect = 3e-60
Identities = 209/703 (29%), Positives = 314/703 (44%), Gaps = 66/703 (9%)
Query: 117 KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ 176
K+ I V D NDNAP F + ++ IPENT + + I +ATDPD G G Y
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 177 FFAIDSARGI-------VTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV 229
F +D + V + LD E Y + + D + ST A L + ++DV
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSST-AILQVTVSDV 245
Query: 230 QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI---VSGNTNSIFAL 286
D P+F +I E++P GT+V + A D D G I Y V+ T +FAL
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 287 DYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAP 346
+ +G++T+ LDRE +L G+ TP+ ATVT I V D+NDN P
Sbjct: 306 NNTTGLITVQRSLDREETAIHKVTVLASDGSS-----TPARATVT----INVTDVNDNPP 356
Query: 347 EFNSSEY------SVAITELAQVGFALPLFIQVVDKDENLG------LNSMFEVYLVGNN 394
+ +V ++E V + L I V DKD ++ + +L
Sbjct: 357 NIDLRYIISPINGTVYLSEKDPVNTKIAL-ITVSDKDTDVNGKVICFIEREVPFHLKAVY 415
Query: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINE 453
+ +++ +S+ LDYE + F + A++S P A V++ L +E
Sbjct: 416 DNQYLLETSSL-------------LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 513
NDN PIF+QP+ +S+ EN G + T+ ATD D+G ++ Y + F LD+ TG
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTG 522
Query: 514 LIMLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKDAYVGALR 571
++ D E +RF T+ ARD G ++ V + VLD NDN P F + + +
Sbjct: 523 VLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVS 582
Query: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ 631
EN P + + + TD D+ N +T SI++ + F + Y GVI + D EQ
Sbjct: 583 ENLPKYSTVGVITVTDADAGENKAVTLSILNDN---DNFVLDPYS--GVIKSNVSFDREQ 637
Query: 632 ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKP---AYFVSVVENIMAGA 688
S+ V A D G PP +ST VTI V D NDN P P F V + + G+
Sbjct: 638 QSS--YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGS 695
Query: 689 TVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748
V + A D+D + I S FRI+ +G IT + L+V
Sbjct: 696 VVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNI 755
Query: 749 VDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
D G + T+ + L +ND T +A Y +L+ T
Sbjct: 756 SDLG----YPKSLHTLVLVFLYVND---TAGNASYIYDLIRRT 791
Score = 230 bits (586), Expect = 2e-59
Identities = 213/745 (28%), Positives = 338/745 (45%), Gaps = 70/745 (9%)
Query: 1854 LPMNITISENSPVSSFVAHVLASDADSGCNARLTFNIT--AGNRERAFFINATTGIVTVN 1911
LP N+ I N P ++H+ +A +G +A L + + AG+ ++T I T +
Sbjct: 34 LPENVPIG-NIPKDLNISHI---NAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTS 89
Query: 1912 RPLDRERIPEYKLTISVKDNPENPR-------IARRDYDLLL---IFLSDENDNHPLFTK 1961
+DRE KL EN I D+ L+ I + D NDN P+F
Sbjct: 90 NRIDRE-----KLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPS 144
Query: 1962 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS--GLFDINSSTGVV 2019
+ EN+ + + + A D D V Y+LL QS GL + + G
Sbjct: 145 PVINISIPENTLINSRFPIPS----ATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEK 200
Query: 2020 TVRSGVI--IDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVH 2077
+ V +DRE ++++ + +STA L +T+ D NDNRP F + VH
Sbjct: 201 WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVH 260
Query: 2078 LLENCPPGFSVLQVTATDEDSGLNGELVY----RIEAGAQDRFLIHLVTGVIRVGNATID 2133
+ EN P G SV+Q+ ATD D G N E+ Y ++ + F ++ TG+I V ++D
Sbjct: 261 IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV-QRSLD 319
Query: 2134 REEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF-----LNPIQTVSVLESAE 2188
REE +++TV+A+D + P T VTI + D+ND+ P ++PI L +
Sbjct: 320 REETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYIISPINGTVYLSEKD 377
Query: 2189 P-GTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMN 2247
P T IA IT D D + + ++ + ++ L ++ + + T S++
Sbjct: 378 PVNTKIALITVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYL--LETSSLL------ 427
Query: 2248 RELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILE 2307
+ T E + ++ + S P + + A + V + D NDN P F I + E
Sbjct: 428 -DYEGTKEFSFKIVASDSGKPSLNQT---ALVRVKLEDENDNPPIFNQPVIEL---SVSE 480
Query: 2308 GATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHW 2367
G L ++A D D G N + Y L P D G + A+R D EE
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVY---QLGPNASFFDLDRKTGVLTASRVFDREEQER 537
Query: 2368 LNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTAT 2427
FTV A DNG+PP ++ V + ++D NDN+P F +Q V E++P + + +T T
Sbjct: 538 FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVT 597
Query: 2428 DADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASN 2487
DAD+G + S+ + F ++P +G I S DRE++ Y A D
Sbjct: 598 DADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDG----GQP 653
Query: 2488 RRENSVQVVIQVLDVNDCRPQFSKPQFSTS---VYENEPAGTSVITMMATDQDEGPNGEL 2544
R ++ +V I V+DVND P P +TS V + G+ V + A D D G N EL
Sbjct: 654 PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713
Query: 2545 TYSL-EGPGVEAFHVDMDSGLVTTQ 2568
Y++ G F +D +G +T +
Sbjct: 714 KYTIVSGNNKGLFRIDPVTGNITLE 738
Score = 230 bits (586), Expect = 2e-59
Identities = 217/741 (29%), Positives = 328/741 (44%), Gaps = 76/741 (10%)
Query: 1361 LFKIDAITG-VITVQGLVDREK-----------GDFYTLTVVADDGGPKVDSTVKVYITV 1408
L K+ + TG + T +DREK F+ L VV +K+ I V
Sbjct: 75 LVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPND--FFRLIKIKIIV 132
Query: 1409 LDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFE 1468
D NDN+P F + +SIPE+ + R A DPD G NG + L +G +
Sbjct: 133 KDTNDNAPMFPSPVIN-ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLD 191
Query: 1469 IVTT--NDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPV 1526
IV T + ++ V + LDRE+ D Y++++ D GTP + ILQVT+ D+NDN PV
Sbjct: 192 IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251
Query: 1527 IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYY----ITEGNKDMAFRMDRIS 1582
+ V + EN GT+V+Q+ ATD DIG N+ + Y + K + F ++ +
Sbjct: 252 FKEG-QVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTT 309
Query: 1583 GEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHY--- 1639
G I + + DRE + H V + +G+ T + T V + + D NDN P +
Sbjct: 310 GLITVQRSL-DREETAI-HKVTVLASDGSSTPARAT-VTINVTDVNDNPPNIDLRYIISP 366
Query: 1640 ---EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAK 1696
V L E D +NT + I D D NG V I + + + ++ +
Sbjct: 367 INGTVYLSE-KDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS 425
Query: 1697 ELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE 1756
LDYE + IV + P L+ T V V + D NDN P F +
Sbjct: 426 LLDYEGTKEFSFKIVASDSGKPSLNQ----TALVRVKLEDENDNPPIFNQPVIELSVSEN 481
Query: 1757 GQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAF 1816
+ G + T A D DSG N + Y + G F + GVL + DRE
Sbjct: 482 NRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR--VFDREEQER 537
Query: 1817 YNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLAS 1876
+ T+ ARD G PPL S V + VLD NDN P + +SEN P S V + +
Sbjct: 538 FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVT 597
Query: 1877 DADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPR 1936
DAD+G N +T +I N F ++ +G++ N DRE+ Y + D + PR
Sbjct: 598 DADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
Query: 1937 IARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT-----PLTVLNGPIL----A 1987
+ + I + D NDN P V+ + P+ T PL+ + G ++ A
Sbjct: 656 SSTAK---VTINVMDVNDNSP----------VVISPPSNTSFKLVPLSAIPGSVVAEVFA 702
Query: 1988 LDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPP---ILELLLLA 2043
+D D + A + Y ++ G GLF I+ TG +T+ E +P + L++
Sbjct: 703 VDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL-------EEKPAPTDVGLHRLVVNI 755
Query: 2044 EDIGLLNSTAHLLITILDDND 2064
D+G S L++ L ND
Sbjct: 756 SDLGYPKSLHTLVLVFLYVND 776
Score = 211 bits (538), Expect = 7e-54
Identities = 210/761 (27%), Positives = 323/761 (42%), Gaps = 58/761 (7%)
Query: 792 PPDSDVTTVVAVDPDLGENGTLVYSIQPPN---KFYSLNSTTGKIRTTHAMLDREN---- 844
P D +++ + A G + +LVY + ++S+TG+I TT +DRE
Sbjct: 44 PKDLNISHINAAT---GTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAG 100
Query: 845 ---PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 901
+ +E ++V+ D R + + + D NDN P F + + E
Sbjct: 101 ASYAEENECFFELEVVILPNDFFR-------LIKIKIIVKDTNDNAPMFPSPVINISIPE 153
Query: 902 GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDF-LINSSSGV----VVTTTELDRE 956
A D D G NG+ Y + G ++ + G ++ LDRE
Sbjct: 154 NTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDRE 213
Query: 957 RIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW 1016
+ Y +++ D GTP KSST+ L + V DVND P F V + E+ P V+
Sbjct: 214 QKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQ 273
Query: 1017 LNCTDNDVGLNAELSYFITGGNV----DGKFSVGYRDAVVRTVVGLDRETTAAYMLILEA 1072
L+ TD D+G NAE+ Y I G V F++ ++ LDRE TA + + + A
Sbjct: 274 LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA 332
Query: 1073 IDNGPVGKRHTGTATVFVTVLDVNDNRP------IFLQSSYEASVPEDIPEGHSILQLKA 1126
D G ATV + V DVNDN P I + + E P I +
Sbjct: 333 SD----GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITV 388
Query: 1127 TDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG 1186
+D D G+V + + + N L+ LD E + A +
Sbjct: 389 SDKDTDVNGKV-ICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKP 447
Query: 1187 PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNY 1246
+ + V V +ED ND P+F Q L + E G + + ATD DSG + Y
Sbjct: 448 SLNQTALVRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY 506
Query: 1247 RILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNE 1306
++ A F++D TG++ D E + ++ V+A D P Q +V +T+L+E
Sbjct: 507 QLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Query: 1307 LDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA 1366
D + +F++ ++ + ENL + + + D + F +D
Sbjct: 566 NDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---FVLDP 622
Query: 1367 ITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRF--DFTSD 1423
+GVI DRE+ YT V A DGG P ST KV I V+D NDNSP ++
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1424 SAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI--VTTNDSIGEVFV 1481
S +P G VA V A D D G N ++ +++ SGN G F I VT N ++ E
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEE--- 739
Query: 1482 ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDIND 1522
+P + H ++ V SD G P K H L + L +ND
Sbjct: 740 -KPAPTDVGLHRLV-VNISDLGYP--KSLHTLVLVFLYVND 776
Score = 202 bits (513), Expect = 6e-51
Identities = 226/796 (28%), Positives = 337/796 (42%), Gaps = 94/796 (11%)
Query: 137 YSVR--IPENTPVGTPIFIVNATDPDLGAGGSV-----LYSFQPPSQFFAIDSARG-IVT 188
Y++R +PEN P+G +N + + G S L S + + S+ G I T
Sbjct: 28 YTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFT 87
Query: 189 VIRELDYETTQA-----------YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFI 237
+D E A ++L V D R L + II+ D D P+F
Sbjct: 88 TSNRIDREKLCAGASYAEENECFFELEVVILPNDFFR----LIKIKIIVKDTNDNAPMFP 143
Query: 238 NLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYIS------- 290
+ + +I E++ + I +A D D G Y +++G S+F LD +
Sbjct: 144 SPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEGEKW 201
Query: 291 GVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
L + LDRE +++ +K + D TP ++ T + V D+NDN P F
Sbjct: 202 PQLIVQQNLDREQ---KDTYVMKIK---VEDGGTPQKSS-TAILQVTVSDVNDNRPVFKE 254
Query: 351 SEYSVAITELAQVGFALPLFIQVVDKDENLGLNS----MFEVYLVGNNSHHFIISPTSVQ 406
+ V I E A VG ++ IQ+ D ++G N+ +F + F ++ T+
Sbjct: 255 GQVEVHIPENAPVGTSV---IQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTG- 310
Query: 407 GKADIRIRVAIPLDYETVDRYDFDLFANE--SVPDHVGYAKVKITLINENDNRP------ 458
I V LD E + + A++ S P A V I + + NDN P
Sbjct: 311 -----LITVQRSLDREETAIHKVTVLASDGSSTP---ARATVTINVTDVNDNPPNIDLRY 362
Query: 459 IFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD-PDRFSLDKDTG-LIM 516
I S + L E V T + + +D D G+V F + P D L+
Sbjct: 363 IISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE 422
Query: 517 LIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENE 574
+ LDYE + F+ I+A D G T VR+ + D NDN P F + ++ EN
Sbjct: 423 TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENN 482
Query: 575 PSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISN 634
L + ATDEDS N I Y + S+FD+ GV++ SR D E+
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQL---GPNASFFDLD--RKTGVLTASRVFDREEQER 537
Query: 635 GLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLN 694
TV A D G PPL S V + V DENDN P F+ + V EN+ +TV +
Sbjct: 538 --FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT 595
Query: 695 ATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVG 754
TD D + + L + F ++ SG I + DRE +S Y V+A DGG
Sbjct: 596 VTDADAGE--NKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653
Query: 755 HNQKTGIATVNITLLDINDNHPTWKDAP--YYINLVEMTP-PDSDVTTVVAVDPDLGENG 811
T T+N+ +D+NDN P P LV ++ P S V V AVD D G N
Sbjct: 654 PRSSTAKVTINV--MDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 812 TLVYSIQPPNK--FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLK 869
L Y+I N + ++ TG I E P P + L R +VV+++D G P
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGNITL------EEKPAPTDVGLHR-LVVNISDLGYP--- 761
Query: 870 ATSSATVFVNLLDLND 885
S T+ + L +ND
Sbjct: 762 -KSLHTLVLVFLYVND 776
Score = 191 bits (485), Expect = 1e-47
Identities = 190/665 (28%), Positives = 304/665 (45%), Gaps = 82/665 (12%)
Query: 2386 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 2445
I + + + D NDN P+F P ++ E+ + + +ATD D+G + Y L +G+
Sbjct: 126 IKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQ 185
Query: 2446 SKFAINPTTG-------DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2498
S F ++ + V +LDRE+KD Y++ +D + ++ ++ + +
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDG----GTPQKSSTAILQVT 241
Query: 2499 VLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA--- 2555
V DVND RP F + Q + EN P GTSVI + ATD D G N E+ Y A
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
Query: 2556 -FHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRP--- 2609
F ++ +GL+T QR L E +TV+A+DG P T + + V DVNDN P
Sbjct: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNID 359
Query: 2610 --VFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFI-- 2665
+ P NGT+ ++ E+ P+ + + + +DKD +NG V F++ R+ F +
Sbjct: 360 LRYIISPINGTV-YLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIE----REVPFHLKA 413
Query: 2666 IDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRP 2725
+ L++T+ LD E +S +VASD G+P +T ++V LED +DN P+F +P
Sbjct: 414 VYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL-VRVKLEDENDNPPIFNQP 472
Query: 2726 PKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHL-QPDGC 2784
L+V E++ RG + ++ A D D G NA + Y + G F L + G
Sbjct: 473 VIE------LSVSENNRRGLYLTTIS-ATDEDSGKNADIVYQL--GPNASFFDLDRKTGV 523
Query: 2785 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPP 2844
L R DRE + F F V A N TPP V V + D ND P
Sbjct: 524 LTASRVFDREEQERFIFTVTARDNG--TPPLQSQAA-----------VIVTVLDENDNSP 570
Query: 2845 RFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQV 2904
+FT + V+ + S + + DAD G N V SIL ND+++
Sbjct: 571 KFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSIL---------NDNDN---- 617
Query: 2905 FTMGSMDGILRTFDLFMAYSPGYFVVDIVARD--LAGHNDTAIIGIYILRDDQRVKIVIN 2962
F + G++++ F + D+ A D + TA + I ++ + +VI+
Sbjct: 618 FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVIS 677
Query: 2963 EIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRIL 3022
P F+ + LS I G++V F VD +N EL +V+ + +
Sbjct: 678 --PPSNTSFK---LVPLSAIPGSVVAE---VFAVDVDTGMN---AELKYTIVSGNNKGLF 726
Query: 3023 DVDRV 3027
+D V
Sbjct: 727 RIDPV 731
Score = 181 bits (459), Expect = 1e-44
Identities = 178/627 (28%), Positives = 279/627 (44%), Gaps = 56/627 (8%)
Query: 69 VSGEEASRFFAVEPDTGVVW----LRQPLDRETKSEFTVEFSVSDH---QGVITRKVNIQ 121
++G+ VE G W ++Q LDRE K + ++ V D Q T + +
Sbjct: 182 LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241
Query: 122 VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF-----QPPSQ 176
V DVNDN P F V IPEN PVGT + ++ATD D+G+ + Y F +
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
Query: 177 FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQD----M 232
FA+++ G++TV R LD E T +++TV A+D T A + I +TDV D +
Sbjct: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSST---PARATVTINVTDVNDNPPNI 358
Query: 233 DPIFINLPYSTNIY--EHSPPGTTVRIITAIDQD---KGRPRGIGYTIVSGNTNSIFALD 287
D +I P + +Y E P T + +IT D+D G+ V + +++
Sbjct: 359 DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ 418
Query: 288 YISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE 347
Y+ L + LLD E I+ +D PS T + + D NDN P
Sbjct: 419 YL---LETSSLLDYEGTKEFSFKIVA------SDSGKPS-LNQTALVRVKLEDENDNPPI 468
Query: 348 FNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
FN ++++E + G L + DE+ G N+ VY +G N+ F +
Sbjct: 469 FNQPVIELSVSENNRRGLYL---TTISATDEDSGKNADI-VYQLGPNASFF-----DLDR 519
Query: 408 KADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYN 466
K + + + D E +R+ F + A ++ P A V +T+++ENDN P F+ +
Sbjct: 520 KTGV-LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQ 578
Query: 467 ISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELI 526
+ EN+ ++V + TD DAG V+ +D D F LD +G+I D E
Sbjct: 579 FFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQ 638
Query: 527 QRFTLTIIARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSV---TQLV 581
+T + A DGG +T +V INV+DVNDN P + + S + +
Sbjct: 639 SSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVA 698
Query: 582 RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTV 641
+ A D D+ N ++ Y+IVS + G + + + P D GL L V
Sbjct: 699 EVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDV-----GLHRLVV 753
Query: 642 MAMDAGNP-PLNSTVPVTIEVFDENDN 667
D G P L++ V V + V D N
Sbjct: 754 NISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 150 bits (379), Expect = 2e-35
Identities = 145/500 (29%), Positives = 222/500 (44%), Gaps = 47/500 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMD-----NDPLVFGVSGEEAS-RFFAVEPDTGVVWLRQPLDR 95
I E+ PVG+SV QL A D D +FG A+ R FA+ TG++ +++ LDR
Sbjct: 261 IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDR 320
Query: 96 ETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPY------SVRIPENTPVG 148
E + V SD R V I V DVNDN P + +V + E PV
Sbjct: 321 EETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVN 380
Query: 149 TPIFIVNATDPDLGAGGSVL--YSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
T I ++ +D D G V+ + P A+ + ++ LDYE T+ + +
Sbjct: 381 TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIV 440
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
A+D K L+ A + + + D D PIF ++ E++ G + I+A D+D G
Sbjct: 441 ASDSGKP-SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSG 499
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
+ I Y + G S F LD +GVLT + + DRE FI TV + S
Sbjct: 500 KNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREE---QERFIFTVTARDNGTPPLQS 554
Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQV---VDKDENLGLN 383
A V T V+D NDN+P+F + + ++E LP + V D + G N
Sbjct: 555 QAAVIVT----VLDENDNSPKFTHNHFQFFVSE------NLPKYSTVGVITVTDADAGEN 604
Query: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVG 442
+ ++ N++ +F++ P S K++ + D E Y FD+ A + P
Sbjct: 605 KAVTLSIL-NDNDNFVLDPYSGVIKSN------VSFDREQQSSYTFDVKATDGGQPPRSS 657
Query: 443 YAKVKITLINENDNRPIFSQPLYNIS---LYENVTVGTSVLTVLATDNDAGTFGEVSYFF 499
AKV I +++ NDN P+ P N S + + G+ V V A D D G E+ Y
Sbjct: 658 TAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTI 717
Query: 500 --SDDPDRFSLDKDTGLIML 517
++ F +D TG I L
Sbjct: 718 VSGNNKGLFRIDPVTGNITL 737
Score = 145 bits (365), Expect = 9e-34
Identities = 157/555 (28%), Positives = 238/555 (42%), Gaps = 65/555 (11%)
Query: 2408 QEAVFEDVPVGTII--LTVTATDADSGNFALIEYSLGD--GESKFA-INPTTGDIYVLSS 2462
+E + E+VP+G I L ++ +A +G A + Y L G++ ++ +TG+I+ S+
Sbjct: 31 REELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSN 90
Query: 2463 -LDREKKDHYILTALAKDNPGD------VASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515
+DREK + A++N + N +++ I V D ND P F P +
Sbjct: 91 RIDREKL--CAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVIN 148
Query: 2516 TSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSG---------LVT 2566
S+ EN + ATD D G NG Y L G F +D+ +V
Sbjct: 149 ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLN-GQSVFGLDIVETPEGEKWPQLIVQ 207
Query: 2567 TQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI-LHIREE 2625
+ + + + + DGG P T +L V V DVNDNRPVF G + +HI E
Sbjct: 208 QNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVF---KEGQVEVHIPEN 264
Query: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQA 2685
P+ ++V +++ATD D G N +RY F F ++ +GLI + LDRE A
Sbjct: 265 APVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETA 324
Query: 2686 VYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGT 2745
++ + ++ASD G P + V D++DN P SP + + E P T
Sbjct: 325 IHKVTVLASD-GSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGTVYLSEKDPVNT 381
Query: 2746 LVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP--DGCLLVLRD--LDREREAIFSF 2801
+ +T D D N V FI E FHL+ D L+ LD E FSF
Sbjct: 382 KIALIT-VSDKDTDVNGKVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSF 437
Query: 2802 IVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKV 2861
+ AS + P+L+ A VRV LED ND PP F + V+ + +
Sbjct: 438 KIVASDS--------GKPSLNQTA-----LVRVKLEDENDNPPIFNQPVIELSVSENNRR 484
Query: 2862 GSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFM 2921
G L + A D D G N+ + Y + F F + G+L +F
Sbjct: 485 GLYLTTISATDEDSGKNADIVYQLGPNASF-------------FDLDRKTGVLTASRVFD 531
Query: 2922 AYSPGYFVVDIVARD 2936
F+ + ARD
Sbjct: 532 REEQERFIFTVTARD 546
>gi|45243534 protocadherin 9 isoform 1 precursor [Homo sapiens]
Length = 1237
Score = 285 bits (730), Expect = 4e-76
Identities = 241/789 (30%), Positives = 374/789 (47%), Gaps = 70/789 (8%)
Query: 1963 TYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLG--AQSGLFDINSSTGVVT 2020
T + E+ EN P G LN I ++A A + Y+L+ + L ++SSTG +
Sbjct: 29 TIREELPENVPIGNIPKDLN--ISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIF 86
Query: 2021 VRSGVIIDREAFSPPI-----------LELLLLAEDIGLLNSTAHLLITILDDNDNRPTF 2069
S I DRE LE+++L D L + I + D NDN P F
Sbjct: 87 TTSNRI-DREKLCAGASYAEENECFFELEVVILPNDFFRL---IKIKIIVKDTNDNAPMF 142
Query: 2070 SPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIR--- 2126
+ + + EN +ATD D+G NG Y + G Q F + +V
Sbjct: 143 PSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG-QSVFGLDIVETPEGEKW 201
Query: 2127 ---VGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
+ +DRE++++Y + + D GT S TAI+ + + D+ND+RP F V +
Sbjct: 202 PQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHI 261
Query: 2184 LESAEPGTVIANITAIDHDLNPKLEY-HIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMV 2242
E+A GT + + A D D+ E +I G T RL FA+N TG + V
Sbjct: 262 PENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-------FALNNTTGLITV 314
Query: 2243 KSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQF------KPF 2296
+ ++RE A ++VT+ D +S P R A +T+NV DVNDN P P
Sbjct: 315 QRSLDREETAIHKVTVLASDGSST-PAR------ATVTINVTDVNDNPPNIDLRYIISPI 367
Query: 2297 GITYYMERILEGATPGTTLIAVAAV-DPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVI 2355
T Y+ P T IA+ V D D +NG V ++ P +++ + +
Sbjct: 368 NGTVYLSE----KDPVNTKIALITVSDKDTDVNGKVI-CFIEREVPFHLKAVYDNQYLLE 422
Query: 2356 ANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDV 2415
+ +DYE +F + ASD+G P V +++ D NDN PIF+QP + +V E+
Sbjct: 423 TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENN 482
Query: 2416 PVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTA 2475
G + T++ATD DSG A I Y LG S F ++ TG + DRE+++ +I T
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTGVLTASRVFDREEQERFIFTV 542
Query: 2476 LAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATD 2535
A+DN + ++ V++ VLD ND P+F+ F V EN P ++V + TD
Sbjct: 543 TARDN----GTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVTD 598
Query: 2536 QDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQSYEKFSLT--VVATDGGEPPLWG 2593
D G N +T S+ + F +D SG++ + ++ S T V ATDGG+PP
Sbjct: 599 ADAGENKAVTLSILNDN-DNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSS 657
Query: 2594 TTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLR----SNVYEVYATDKDEGLNGAVR 2649
T + + V+DVNDN PV + PP+ T + +PL S V EV+A D D G+N ++
Sbjct: 658 TAKVTINVMDVNDNSPVVISPPSNTSFKL---VPLSAIPGSVVAEVFAVDVDTGMNAELK 714
Query: 2650 YSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQ 2709
Y+ + +GN F IDP++G I ++ ++ L++ SDLG P T+ +
Sbjct: 715 YTIV--SGNNK-GLFRIDPVTGNITLEEKPAPTDVGLHRLVVNISDLGYPKSLHTLVLVF 771
Query: 2710 VALEDIDDN 2718
+ + D N
Sbjct: 772 LYVNDTAGN 780
Score = 255 bits (652), Expect = 5e-67
Identities = 202/683 (29%), Positives = 317/683 (46%), Gaps = 42/683 (6%)
Query: 325 PSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNS 384
P+D I+V D NDNAP F S +++I E + P+ D + G N
Sbjct: 119 PNDFFRLIKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPI---PSATDPDTGFNG 175
Query: 385 MFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVGY 443
+ L+ S + + +G+ ++ V LD E D Y + + P
Sbjct: 176 VQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSST 235
Query: 444 AKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD- 502
A +++T+ + NDNRP+F + + + EN VGTSV+ + ATD D G+ E+ Y F
Sbjct: 236 AILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQV 295
Query: 503 ----PDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNV 558
F+L+ TGLI + LD E +T++A DG V INV DVNDN
Sbjct: 296 APATKRLFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARATVTINVTDVNDNP 355
Query: 559 PTFQKDAYVGA------LRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDI 612
P + L E +P T++ + +D+D+ N ++ I F
Sbjct: 356 PNIDLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLK--- 412
Query: 613 SLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFS 672
++Y+ ++ S LDYE ++A D+G P LN T V +++ DENDNPP F+
Sbjct: 413 AVYDNQYLLETSSLLDYEGTKE--FSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFN 470
Query: 673 KPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSL-EGSTQFRINARSGEITTT 731
+P +SV EN G + ++ATD D + I+Y L ++ F ++ ++G +T +
Sbjct: 471 QPVIELSVSENNRRGLYLTTISATDEDSGK---NADIVYQLGPNASFFDLDRKTGVLTAS 527
Query: 732 SLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
+ DRE + +I V A D G Q A V +T+LD NDN P + + + E
Sbjct: 528 RVFDREEQERFIFTVTARDNGTPPLQSQ--AAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 792 PPDSDVTTVVAVDPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAE 851
P S V + D D GEN + SI N + L+ +G I+ ++ DRE + +
Sbjct: 586 PKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIK-SNVSFDREQQSSYTFD 644
Query: 852 LMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF----QNLPFVAEVLEGIPAGV 907
V TD G+PP +S+A V +N++D+NDN P N F L IP V
Sbjct: 645 ------VKATDGGQPP--RSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSV 696
Query: 908 SIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVA 967
+ +V A+D+D G+N + Y + G + F I+ +G + + + ++L V
Sbjct: 697 -VAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNI 755
Query: 968 SDAGTPTKSSTSTLTIHVLDVND 990
SD G P S TL + L VND
Sbjct: 756 SDLGYP--KSLHTLVLVFLYVND 776
Score = 236 bits (602), Expect = 3e-61
Identities = 189/633 (29%), Positives = 303/633 (47%), Gaps = 45/633 (7%)
Query: 655 VPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLE 714
+ + I V D NDN P F P +S+ EN + + +ATD D Q + L
Sbjct: 126 IKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYEL--LN 183
Query: 715 GSTQFRINA-------RSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIATVNIT 767
G + F ++ + ++ LDRE K Y++ ++ DGG QK+ A + +T
Sbjct: 184 GQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTP--QKSSTAILQVT 241
Query: 768 LLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENGTLVY----SIQPPNK- 822
+ D+NDN P +K+ +++ E P + V + A D D+G N + Y + P K
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
Query: 823 FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLD 882
++LN+TTG I T LDRE H K+ V +D P + ATV +N+ D
Sbjct: 302 LFALNNTTGLI-TVQRSLDREETAIH------KVTVLASDGSSTPAR----ATVTINVTD 350
Query: 883 LNDNDPTFQNLPFVAEVLEGI-------PAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPR 935
+NDN P +L ++ + G P I + D D +NG V + +P
Sbjct: 351 VNDNPPNI-DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPF 409
Query: 936 MDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTF 995
+ + ++ T++ LD E E+ ++VASD+G P+ + T+ + + + D ND P F
Sbjct: 410 HLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIF 469
Query: 996 FPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTV 1055
V +SVSE+ R + ++ TD D G NA++ Y + G F + + V+
Sbjct: 470 NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTAS 527
Query: 1056 VGLDRETTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDI 1115
DRE ++ + A DNG + A V VTVLD NDN P F + ++ V E++
Sbjct: 528 RVFDREEQERFIFTVTARDNGTPPLQ--SQAAVIVTVLDENDNSPKFTHNHFQFFVSENL 585
Query: 1116 PEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHV 1175
P+ ++ + TDAD GE V IL+ N +NF + +G++ + DRE+ SS+
Sbjct: 586 PKYSTVGVITVTDADAGENKAVTLSILNDN--DNFVLDPYSGVI-KSNVSFDREQQSSYT 642
Query: 1176 LIVEAYNHDLGPMRSSVRVIVYVEDINDEAP-VFTQQQYSRLGLRETAGIGTSVIV-VQA 1233
V+A + P S+ +V + V D+ND +P V + + L + I SV+ V A
Sbjct: 643 FDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFA 702
Query: 1234 TDRDSGDGGLVNYRILSG-AEGKFEIDESTGLI 1265
D D+G + Y I+SG +G F ID TG I
Sbjct: 703 VDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNI 735
Score = 233 bits (593), Expect = 3e-60
Identities = 209/703 (29%), Positives = 314/703 (44%), Gaps = 66/703 (9%)
Query: 117 KVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ 176
K+ I V D NDNAP F + ++ IPENT + + I +ATDPD G G Y
Sbjct: 127 KIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQS 186
Query: 177 FFAIDSARGI-------VTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDV 229
F +D + V + LD E Y + + D + ST A L + ++DV
Sbjct: 187 VFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSST-AILQVTVSDV 245
Query: 230 QDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTI---VSGNTNSIFAL 286
D P+F +I E++P GT+V + A D D G I Y V+ T +FAL
Sbjct: 246 NDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFAL 305
Query: 287 DYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAP 346
+ +G++T+ LDRE +L G+ TP+ ATVT I V D+NDN P
Sbjct: 306 NNTTGLITVQRSLDREETAIHKVTVLASDGSS-----TPARATVT----INVTDVNDNPP 356
Query: 347 EFNSSEY------SVAITELAQVGFALPLFIQVVDKDENLG------LNSMFEVYLVGNN 394
+ +V ++E V + L I V DKD ++ + +L
Sbjct: 357 NIDLRYIISPINGTVYLSEKDPVNTKIAL-ITVSDKDTDVNGKVICFIEREVPFHLKAVY 415
Query: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINE 453
+ +++ +S+ LDYE + F + A++S P A V++ L +E
Sbjct: 416 DNQYLLETSSL-------------LDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDE 462
Query: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTG 513
NDN PIF+QP+ +S+ EN G + T+ ATD D+G ++ Y + F LD+ TG
Sbjct: 463 NDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVYQLGPNASFFDLDRKTG 522
Query: 514 LIMLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKDAYVGALR 571
++ D E +RF T+ ARD G ++ V + VLD NDN P F + + +
Sbjct: 523 VLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVS 582
Query: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQ 631
EN P + + + TD D+ N +T SI++ + F + Y GVI + D EQ
Sbjct: 583 ENLPKYSTVGVITVTDADAGENKAVTLSILNDN---DNFVLDPYS--GVIKSNVSFDREQ 637
Query: 632 ISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKP---AYFVSVVENIMAGA 688
S+ V A D G PP +ST VTI V D NDN P P F V + + G+
Sbjct: 638 QSS--YTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGS 695
Query: 689 TVLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748
V + A D+D + I S FRI+ +G IT + L+V
Sbjct: 696 VVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDVGLHRLVVNI 755
Query: 749 VDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT 791
D G + T+ + L +ND T +A Y +L+ T
Sbjct: 756 SDLG----YPKSLHTLVLVFLYVND---TAGNASYIYDLIRRT 791
Score = 230 bits (586), Expect = 2e-59
Identities = 213/745 (28%), Positives = 338/745 (45%), Gaps = 70/745 (9%)
Query: 1854 LPMNITISENSPVSSFVAHVLASDADSGCNARLTFNIT--AGNRERAFFINATTGIVTVN 1911
LP N+ I N P ++H+ +A +G +A L + + AG+ ++T I T +
Sbjct: 34 LPENVPIG-NIPKDLNISHI---NAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTS 89
Query: 1912 RPLDRERIPEYKLTISVKDNPENPR-------IARRDYDLLL---IFLSDENDNHPLFTK 1961
+DRE KL EN I D+ L+ I + D NDN P+F
Sbjct: 90 NRIDRE-----KLCAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPS 144
Query: 1962 STYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQS--GLFDINSSTGVV 2019
+ EN+ + + + A D D V Y+LL QS GL + + G
Sbjct: 145 PVINISIPENTLINSRFPIPS----ATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEK 200
Query: 2020 TVRSGVI--IDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVH 2077
+ V +DRE ++++ + +STA L +T+ D NDNRP F + VH
Sbjct: 201 WPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVH 260
Query: 2078 LLENCPPGFSVLQVTATDEDSGLNGELVY----RIEAGAQDRFLIHLVTGVIRVGNATID 2133
+ EN P G SV+Q+ ATD D G N E+ Y ++ + F ++ TG+I V ++D
Sbjct: 261 IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITV-QRSLD 319
Query: 2134 REEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF-----LNPIQTVSVLESAE 2188
REE +++TV+A+D + P T VTI + D+ND+ P ++PI L +
Sbjct: 320 REETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNIDLRYIISPINGTVYLSEKD 377
Query: 2189 P-GTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMN 2247
P T IA IT D D + + ++ + ++ L ++ + + T S++
Sbjct: 378 PVNTKIALITVSDKDTD--VNGKVICFIEREVPFHLKAVYDNQYL--LETSSLL------ 427
Query: 2248 RELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILE 2307
+ T E + ++ + S P + + A + V + D NDN P F I + E
Sbjct: 428 -DYEGTKEFSFKIVASDSGKPSLNQT---ALVRVKLEDENDNPPIFNQPVIEL---SVSE 480
Query: 2308 GATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHW 2367
G L ++A D D G N + Y L P D G + A+R D EE
Sbjct: 481 NNRRGLYLTTISATDEDSGKNADIVY---QLGPNASFFDLDRKTGVLTASRVFDREEQER 537
Query: 2368 LNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTAT 2427
FTV A DNG+PP ++ V + ++D NDN+P F +Q V E++P + + +T T
Sbjct: 538 FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVT 597
Query: 2428 DADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASN 2487
DAD+G + S+ + F ++P +G I S DRE++ Y A D
Sbjct: 598 DADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDG----GQP 653
Query: 2488 RRENSVQVVIQVLDVNDCRPQFSKPQFSTS---VYENEPAGTSVITMMATDQDEGPNGEL 2544
R ++ +V I V+DVND P P +TS V + G+ V + A D D G N EL
Sbjct: 654 PRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAEL 713
Query: 2545 TYSL-EGPGVEAFHVDMDSGLVTTQ 2568
Y++ G F +D +G +T +
Sbjct: 714 KYTIVSGNNKGLFRIDPVTGNITLE 738
Score = 230 bits (586), Expect = 2e-59
Identities = 217/741 (29%), Positives = 328/741 (44%), Gaps = 76/741 (10%)
Query: 1361 LFKIDAITG-VITVQGLVDREK-----------GDFYTLTVVADDGGPKVDSTVKVYITV 1408
L K+ + TG + T +DREK F+ L VV +K+ I V
Sbjct: 75 LVKVSSSTGEIFTTSNRIDREKLCAGASYAEENECFFELEVVILPND--FFRLIKIKIIV 132
Query: 1409 LDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFE 1468
D NDN+P F + +SIPE+ + R A DPD G NG + L +G +
Sbjct: 133 KDTNDNAPMFPSPVIN-ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLD 191
Query: 1469 IVTT--NDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPV 1526
IV T + ++ V + LDRE+ D Y++++ D GTP + ILQVT+ D+NDN PV
Sbjct: 192 IVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPV 251
Query: 1527 IESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYY----ITEGNKDMAFRMDRIS 1582
+ V + EN GT+V+Q+ ATD DIG N+ + Y + K + F ++ +
Sbjct: 252 FKEG-QVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRL-FALNNTT 309
Query: 1583 GEIATRPAPPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHY--- 1639
G I + + DRE + H V + +G+ T + T V + + D NDN P +
Sbjct: 310 GLITVQRSL-DREETAI-HKVTVLASDGSSTPARAT-VTINVTDVNDNPPNIDLRYIISP 366
Query: 1640 ---EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAK 1696
V L E D +NT + I D D NG V I + + + ++ +
Sbjct: 367 INGTVYLSE-KDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSS 425
Query: 1697 ELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTE 1756
LDYE + IV + P L+ T V V + D NDN P F +
Sbjct: 426 LLDYEGTKEFSFKIVASDSGKPSLNQ----TALVRVKLEDENDNPPIFNQPVIELSVSEN 481
Query: 1757 GQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAF 1816
+ G + T A D DSG N + Y + G F + GVL + DRE
Sbjct: 482 NRRGLYLTTISATDEDSGKNADIVYQL--GPNASFFDLDRKTGVLTASR--VFDREEQER 537
Query: 1817 YNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMNITISENSPVSSFVAHVLAS 1876
+ T+ ARD G PPL S V + VLD NDN P + +SEN P S V + +
Sbjct: 538 FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVITVT 597
Query: 1877 DADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPR 1936
DAD+G N +T +I N F ++ +G++ N DRE+ Y + D + PR
Sbjct: 598 DADAGENKAVTLSILNDNDN--FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPR 655
Query: 1937 IARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGT-----PLTVLNGPIL----A 1987
+ + I + D NDN P V+ + P+ T PL+ + G ++ A
Sbjct: 656 SSTAK---VTINVMDVNDNSP----------VVISPPSNTSFKLVPLSAIPGSVVAEVFA 702
Query: 1988 LDADQDIYAVVTYQLL-GAQSGLFDINSSTGVVTVRSGVIIDREAFSPP---ILELLLLA 2043
+D D + A + Y ++ G GLF I+ TG +T+ E +P + L++
Sbjct: 703 VDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITL-------EEKPAPTDVGLHRLVVNI 755
Query: 2044 EDIGLLNSTAHLLITILDDND 2064
D+G S L++ L ND
Sbjct: 756 SDLGYPKSLHTLVLVFLYVND 776
Score = 211 bits (538), Expect = 7e-54
Identities = 210/761 (27%), Positives = 323/761 (42%), Gaps = 58/761 (7%)
Query: 792 PPDSDVTTVVAVDPDLGENGTLVYSIQPPN---KFYSLNSTTGKIRTTHAMLDREN---- 844
P D +++ + A G + +LVY + ++S+TG+I TT +DRE
Sbjct: 44 PKDLNISHINAAT---GTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSNRIDREKLCAG 100
Query: 845 ---PDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLE 901
+ +E ++V+ D R + + + D NDN P F + + E
Sbjct: 101 ASYAEENECFFELEVVILPNDFFR-------LIKIKIIVKDTNDNAPMFPSPVINISIPE 153
Query: 902 GIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDF-LINSSSGV----VVTTTELDRE 956
A D D G NG+ Y + G ++ + G ++ LDRE
Sbjct: 154 NTLINSRFPIPSATDPDTGFNGVQHYELLNGQSVFGLDIVETPEGEKWPQLIVQQNLDRE 213
Query: 957 RIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW 1016
+ Y +++ D GTP KSST+ L + V DVND P F V + E+ P V+
Sbjct: 214 QKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQ 273
Query: 1017 LNCTDNDVGLNAELSYFITGGNV----DGKFSVGYRDAVVRTVVGLDRETTAAYMLILEA 1072
L+ TD D+G NAE+ Y I G V F++ ++ LDRE TA + + + A
Sbjct: 274 LHATDADIGSNAEIRY-IFGAQVAPATKRLFALNNTTGLITVQRSLDREETAIHKVTVLA 332
Query: 1073 IDNGPVGKRHTGTATVFVTVLDVNDNRP------IFLQSSYEASVPEDIPEGHSILQLKA 1126
D G ATV + V DVNDN P I + + E P I +
Sbjct: 333 SD----GSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVNTKIALITV 388
Query: 1127 TDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG 1186
+D D G+V + + + N L+ LD E + A +
Sbjct: 389 SDKDTDVNGKV-ICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKP 447
Query: 1187 PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNY 1246
+ + V V +ED ND P+F Q L + E G + + ATD DSG + Y
Sbjct: 448 SLNQTALVRVKLEDENDNPPIF-NQPVIELSVSENNRRGLYLTTISATDEDSGKNADIVY 506
Query: 1247 RILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNE 1306
++ A F++D TG++ D E + ++ V+A D P Q +V +T+L+E
Sbjct: 507 QLGPNA-SFFDLDRKTGVLTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDE 565
Query: 1307 LDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDA 1366
D + +F++ ++ + ENL + + + D + F +D
Sbjct: 566 NDNSPKFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDN---FVLDP 622
Query: 1367 ITGVITVQGLVDREKGDFYTLTVVADDGG-PKVDSTVKVYITVLDENDNSPRF--DFTSD 1423
+GVI DRE+ YT V A DGG P ST KV I V+D NDNSP ++
Sbjct: 623 YSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNT 682
Query: 1424 SAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEI--VTTNDSIGEVFV 1481
S +P G VA V A D D G N ++ +++ SGN G F I VT N ++ E
Sbjct: 683 SFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEE--- 739
Query: 1482 ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDIND 1522
+P + H ++ V SD G P K H L + L +ND
Sbjct: 740 -KPAPTDVGLHRLV-VNISDLGYP--KSLHTLVLVFLYVND 776
Score = 202 bits (513), Expect = 6e-51
Identities = 226/796 (28%), Positives = 337/796 (42%), Gaps = 94/796 (11%)
Query: 137 YSVR--IPENTPVGTPIFIVNATDPDLGAGGSV-----LYSFQPPSQFFAIDSARG-IVT 188
Y++R +PEN P+G +N + + G S L S + + S+ G I T
Sbjct: 28 YTIREELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFT 87
Query: 189 VIRELDYETTQA-----------YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDPIFI 237
+D E A ++L V D R L + II+ D D P+F
Sbjct: 88 TSNRIDREKLCAGASYAEENECFFELEVVILPNDFFR----LIKIKIIVKDTNDNAPMFP 143
Query: 238 NLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYIS------- 290
+ + +I E++ + I +A D D G Y +++G S+F LD +
Sbjct: 144 SPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNG--QSVFGLDIVETPEGEKW 201
Query: 291 GVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
L + LDRE +++ +K + D TP ++ T + V D+NDN P F
Sbjct: 202 PQLIVQQNLDREQ---KDTYVMKIK---VEDGGTPQKSS-TAILQVTVSDVNDNRPVFKE 254
Query: 351 SEYSVAITELAQVGFALPLFIQVVDKDENLGLNS----MFEVYLVGNNSHHFIISPTSVQ 406
+ V I E A VG ++ IQ+ D ++G N+ +F + F ++ T+
Sbjct: 255 GQVEVHIPENAPVGTSV---IQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTG- 310
Query: 407 GKADIRIRVAIPLDYETVDRYDFDLFANE--SVPDHVGYAKVKITLINENDNRP------ 458
I V LD E + + A++ S P A V I + + NDN P
Sbjct: 311 -----LITVQRSLDREETAIHKVTVLASDGSSTP---ARATVTINVTDVNDNPPNIDLRY 362
Query: 459 IFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDD-PDRFSLDKDTG-LIM 516
I S + L E V T + + +D D G+V F + P D L+
Sbjct: 363 IISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLE 422
Query: 517 LIARLDYELIQRFTLTIIARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENE 574
+ LDYE + F+ I+A D G T VR+ + D NDN P F + ++ EN
Sbjct: 423 TSSLLDYEGTKEFSFKIVASDSGKPSLNQTALVRVKLEDENDNPPIFNQPVIELSVSENN 482
Query: 575 PSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISN 634
L + ATDEDS N I Y + S+FD+ GV++ SR D E+
Sbjct: 483 RRGLYLTTISATDEDSGKNADIVYQL---GPNASFFDLD--RKTGVLTASRVFDREEQER 537
Query: 635 GLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLN 694
TV A D G PPL S V + V DENDN P F+ + V EN+ +TV +
Sbjct: 538 --FIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQFFVSENLPKYSTVGVIT 595
Query: 695 ATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVG 754
TD D + + L + F ++ SG I + DRE +S Y V+A DGG
Sbjct: 596 VTDADAGE--NKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQP 653
Query: 755 HNQKTGIATVNITLLDINDNHPTWKDAP--YYINLVEMTP-PDSDVTTVVAVDPDLGENG 811
T T+N+ +D+NDN P P LV ++ P S V V AVD D G N
Sbjct: 654 PRSSTAKVTINV--MDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNA 711
Query: 812 TLVYSIQPPNK--FYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLK 869
L Y+I N + ++ TG I E P P + L R +VV+++D G P
Sbjct: 712 ELKYTIVSGNNKGLFRIDPVTGNITL------EEKPAPTDVGLHR-LVVNISDLGYP--- 761
Query: 870 ATSSATVFVNLLDLND 885
S T+ + L +ND
Sbjct: 762 -KSLHTLVLVFLYVND 776
Score = 191 bits (485), Expect = 1e-47
Identities = 190/665 (28%), Positives = 304/665 (45%), Gaps = 82/665 (12%)
Query: 2386 IPVYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGE 2445
I + + + D NDN P+F P ++ E+ + + +ATD D+G + Y L +G+
Sbjct: 126 IKIKIIVKDTNDNAPMFPSPVINISIPENTLINSRFPIPSATDPDTGFNGVQHYELLNGQ 185
Query: 2446 SKFAINPTTG-------DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQ 2498
S F ++ + V +LDRE+KD Y++ +D + ++ ++ + +
Sbjct: 186 SVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDG----GTPQKSSTAILQVT 241
Query: 2499 VLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEA--- 2555
V DVND RP F + Q + EN P GTSVI + ATD D G N E+ Y A
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
Query: 2556 -FHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRP--- 2609
F ++ +GL+T QR L E +TV+A+DG P T + + V DVNDN P
Sbjct: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSSTPARAT--VTINVTDVNDNPPNID 359
Query: 2610 --VFVRPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFI-- 2665
+ P NGT+ ++ E+ P+ + + + +DKD +NG V F++ R+ F +
Sbjct: 360 LRYIISPINGTV-YLSEKDPVNTKIALITVSDKDTDVNGKV-ICFIE----REVPFHLKA 413
Query: 2666 IDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRP 2725
+ L++T+ LD E +S +VASD G+P +T ++V LED +DN P+F +P
Sbjct: 414 VYDNQYLLETSSLLDYEGTKEFSFKIVASDSGKPSLNQTAL-VRVKLEDENDNPPIFNQP 472
Query: 2726 PKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHL-QPDGC 2784
L+V E++ RG + ++ A D D G NA + Y + G F L + G
Sbjct: 473 VIE------LSVSENNRRGLYLTTIS-ATDEDSGKNADIVYQL--GPNASFFDLDRKTGV 523
Query: 2785 LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPP 2844
L R DRE + F F V A N TPP V V + D ND P
Sbjct: 524 LTASRVFDREEQERFIFTVTARDNG--TPPLQSQAA-----------VIVTVLDENDNSP 570
Query: 2845 RFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQV 2904
+FT + V+ + S + + DAD G N V SIL ND+++
Sbjct: 571 KFTHNHFQFFVSENLPKYSTVGVITVTDADAGENKAVTLSIL---------NDNDN---- 617
Query: 2905 FTMGSMDGILRTFDLFMAYSPGYFVVDIVARD--LAGHNDTAIIGIYILRDDQRVKIVIN 2962
F + G++++ F + D+ A D + TA + I ++ + +VI+
Sbjct: 618 FVLDPYSGVIKSNVSFDREQQSSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVIS 677
Query: 2963 EIPDRVRGFEEEFIHLLSNITGAIVNTDNVQFHVDKKGRVNFAQTELLIHVVNRDTNRIL 3022
P F+ + LS I G++V F VD +N EL +V+ + +
Sbjct: 678 --PPSNTSFK---LVPLSAIPGSVVAE---VFAVDVDTGMN---AELKYTIVSGNNKGLF 726
Query: 3023 DVDRV 3027
+D V
Sbjct: 727 RIDPV 731
Score = 181 bits (459), Expect = 1e-44
Identities = 178/627 (28%), Positives = 279/627 (44%), Gaps = 56/627 (8%)
Query: 69 VSGEEASRFFAVEPDTGVVW----LRQPLDRETKSEFTVEFSVSDH---QGVITRKVNIQ 121
++G+ VE G W ++Q LDRE K + ++ V D Q T + +
Sbjct: 182 LNGQSVFGLDIVETPEGEKWPQLIVQQNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVT 241
Query: 122 VGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSF-----QPPSQ 176
V DVNDN P F V IPEN PVGT + ++ATD D+G+ + Y F +
Sbjct: 242 VSDVNDNRPVFKEGQVEVHIPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKR 301
Query: 177 FFAIDSARGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQD----M 232
FA+++ G++TV R LD E T +++TV A+D T A + I +TDV D +
Sbjct: 302 LFALNNTTGLITVQRSLDREETAIHKVTVLASDGSST---PARATVTINVTDVNDNPPNI 358
Query: 233 DPIFINLPYSTNIY--EHSPPGTTVRIITAIDQD---KGRPRGIGYTIVSGNTNSIFALD 287
D +I P + +Y E P T + +IT D+D G+ V + +++
Sbjct: 359 DLRYIISPINGTVYLSEKDPVNTKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQ 418
Query: 288 YISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPE 347
Y+ L + LLD E I+ +D PS T + + D NDN P
Sbjct: 419 YL---LETSSLLDYEGTKEFSFKIVA------SDSGKPS-LNQTALVRVKLEDENDNPPI 468
Query: 348 FNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
FN ++++E + G L + DE+ G N+ VY +G N+ F +
Sbjct: 469 FNQPVIELSVSENNRRGLYL---TTISATDEDSGKNADI-VYQLGPNASFF-----DLDR 519
Query: 408 KADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYN 466
K + + + D E +R+ F + A ++ P A V +T+++ENDN P F+ +
Sbjct: 520 KTGV-LTASRVFDREEQERFIFTVTARDNGTPPLQSQAAVIVTVLDENDNSPKFTHNHFQ 578
Query: 467 ISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELI 526
+ EN+ ++V + TD DAG V+ +D D F LD +G+I D E
Sbjct: 579 FFVSENLPKYSTVGVITVTDADAGENKAVTLSILNDNDNFVLDPYSGVIKSNVSFDREQQ 638
Query: 527 QRFTLTIIARDGG--GEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSV---TQLV 581
+T + A DGG +T +V INV+DVNDN P + + S + +
Sbjct: 639 SSYTFDVKATDGGQPPRSSTAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVA 698
Query: 582 RLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTV 641
+ A D D+ N ++ Y+IVS + G + + + P D GL L V
Sbjct: 699 EVFAVDVDTGMNAELKYTIVSGNNKGLFRIDPVTGNITLEEKPAPTDV-----GLHRLVV 753
Query: 642 MAMDAGNP-PLNSTVPVTIEVFDENDN 667
D G P L++ V V + V D N
Sbjct: 754 NISDLGYPKSLHTLVLVFLYVNDTAGN 780
Score = 150 bits (379), Expect = 2e-35
Identities = 145/500 (29%), Positives = 222/500 (44%), Gaps = 47/500 (9%)
Query: 42 ISEDTPVGSSVTQLLAQDMD-----NDPLVFGVSGEEAS-RFFAVEPDTGVVWLRQPLDR 95
I E+ PVG+SV QL A D D +FG A+ R FA+ TG++ +++ LDR
Sbjct: 261 IPENAPVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDR 320
Query: 96 ETKSEFTVEFSVSDHQGVITR-KVNIQVGDVNDNAPTFHNQPY------SVRIPENTPVG 148
E + V SD R V I V DVNDN P + +V + E PV
Sbjct: 321 EETAIHKVTVLASDGSSTPARATVTINVTDVNDNPPNIDLRYIISPINGTVYLSEKDPVN 380
Query: 149 TPIFIVNATDPDLGAGGSVL--YSFQPPSQFFAIDSARGIVTVIRELDYETTQAYQLTVN 206
T I ++ +D D G V+ + P A+ + ++ LDYE T+ + +
Sbjct: 381 TKIALITVSDKDTDVNGKVICFIEREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSFKIV 440
Query: 207 ATDQDKTRPLSTLANLAIIITDVQDMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKG 266
A+D K L+ A + + + D D PIF ++ E++ G + I+A D+D G
Sbjct: 441 ASDSGKP-SLNQTALVRVKLEDENDNPPIFNQPVIELSVSENNRRGLYLTTISATDEDSG 499
Query: 267 RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPS 326
+ I Y + G S F LD +GVLT + + DRE FI TV + S
Sbjct: 500 KNADIVYQL--GPNASFFDLDRKTGVLTASRVFDREE---QERFIFTVTARDNGTPPLQS 554
Query: 327 DATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQV---VDKDENLGLN 383
A V T V+D NDN+P+F + + ++E LP + V D + G N
Sbjct: 555 QAAVIVT----VLDENDNSPKFTHNHFQFFVSE------NLPKYSTVGVITVTDADAGEN 604
Query: 384 SMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANE-SVPDHVG 442
+ ++ N++ +F++ P S K++ + D E Y FD+ A + P
Sbjct: 605 KAVTLSIL-NDNDNFVLDPYSGVIKSN------VSFDREQQSSYTFDVKATDGGQPPRSS 657
Query: 443 YAKVKITLINENDNRPIFSQPLYNIS---LYENVTVGTSVLTVLATDNDAGTFGEVSYFF 499
AKV I +++ NDN P+ P N S + + G+ V V A D D G E+ Y
Sbjct: 658 TAKVTINVMDVNDNSPVVISPPSNTSFKLVPLSAIPGSVVAEVFAVDVDTGMNAELKYTI 717
Query: 500 --SDDPDRFSLDKDTGLIML 517
++ F +D TG I L
Sbjct: 718 VSGNNKGLFRIDPVTGNITL 737
Score = 145 bits (365), Expect = 9e-34
Identities = 157/555 (28%), Positives = 238/555 (42%), Gaps = 65/555 (11%)
Query: 2408 QEAVFEDVPVGTII--LTVTATDADSGNFALIEYSLGD--GESKFA-INPTTGDIYVLSS 2462
+E + E+VP+G I L ++ +A +G A + Y L G++ ++ +TG+I+ S+
Sbjct: 31 REELPENVPIGNIPKDLNISHINAATGTSASLVYRLVSKAGDAPLVKVSSSTGEIFTTSN 90
Query: 2463 -LDREKKDHYILTALAKDNPGD------VASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515
+DREK + A++N + N +++ I V D ND P F P +
Sbjct: 91 RIDREKL--CAGASYAEENECFFELEVVILPNDFFRLIKIKIIVKDTNDNAPMFPSPVIN 148
Query: 2516 TSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSG---------LVT 2566
S+ EN + ATD D G NG Y L G F +D+ +V
Sbjct: 149 ISIPENTLINSRFPIPSATDPDTGFNGVQHYELLN-GQSVFGLDIVETPEGEKWPQLIVQ 207
Query: 2567 TQRPLQSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTI-LHIREE 2625
+ + + + + DGG P T +L V V DVNDNRPVF G + +HI E
Sbjct: 208 QNLDREQKDTYVMKIKVEDGGTPQKSSTAILQVTVSDVNDNRPVF---KEGQVEVHIPEN 264
Query: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQA 2685
P+ ++V +++ATD D G N +RY F F ++ +GLI + LDRE A
Sbjct: 265 APVGTSVIQLHATDADIGSNAEIRYIFGAQVAPATKRLFALNNTTGLITVQRSLDREETA 324
Query: 2686 VYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGT 2745
++ + ++ASD G P + V D++DN P SP + + E P T
Sbjct: 325 IHKVTVLASD-GSSTPARATVTINVT--DVNDNPPNIDLRYIISPINGTVYLSEKDPVNT 381
Query: 2746 LVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQP--DGCLLVLRD--LDREREAIFSF 2801
+ +T D D N V FI E FHL+ D L+ LD E FSF
Sbjct: 382 KIALIT-VSDKDTDVNGKVICFI---EREVPFHLKAVYDNQYLLETSSLLDYEGTKEFSF 437
Query: 2802 IVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKV 2861
+ AS + P+L+ A VRV LED ND PP F + V+ + +
Sbjct: 438 KIVASDS--------GKPSLNQTA-----LVRVKLEDENDNPPIFNQPVIELSVSENNRR 484
Query: 2862 GSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFM 2921
G L + A D D G N+ + Y + F F + G+L +F
Sbjct: 485 GLYLTTISATDEDSGKNADIVYQLGPNASF-------------FDLDRKTGVLTASRVFD 531
Query: 2922 AYSPGYFVVDIVARD 2936
F+ + ARD
Sbjct: 532 REEQERFIFTVTARD 546
>gi|218505779 protocadherin 15 isoform CD1-6 precursor [Homo sapiens]
Length = 1886
Score = 285 bits (729), Expect = 5e-76
Identities = 306/1078 (28%), Positives = 472/1078 (43%), Gaps = 138/1078 (12%)
Query: 443 YAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVL-----ATDNDAGTFGEVSY 497
Y +V+I + + NDN P F Y ++ E VGT++ T ATD D G G++ Y
Sbjct: 130 YHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEY 189
Query: 498 FFS---DDP---DRFSLDKD-TGLIMLIARLDYELIQRFTLTIIARDGGGE-----ETTG 545
DDP D F + TG I+L RL+YE R+ + I A D TT
Sbjct: 190 VIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTT 249
Query: 546 RVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLV-----------------RLRATDE 588
+ ++VLD +D P F V R+ P Q ++A D+
Sbjct: 250 TLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQ 309
Query: 589 D---SPPNNQ--ITYSIVSASAFGSYFDISLYEGYGVISVSRPL--DYEQISNGLIYLTV 641
D PP+++ I YSI+ + ++ +S+ P+ D+ Q + L +
Sbjct: 310 DRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFD----LVI 365
Query: 642 MAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATV---------LF 692
A PL + + IE+ DEN+ P F+ P+Y ++E+ GAT+ L
Sbjct: 366 KAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLR 425
Query: 693 LNATDLDRSREYGQESIIYSLEGSTQFRINAR--SGEITTTSLLDRETKSEYILIVRAVD 750
+ A D D E ++ + ++ F + + +T +DRE + Y + A D
Sbjct: 426 IVALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFD 485
Query: 751 GGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGEN 810
G Q++ VNI ++D NDN PT+ + Y + + P V + AVD D G N
Sbjct: 486 GV----QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSN 541
Query: 811 GTLVYSIQPPNKF-YSLNSTTGKIRT----------THAM-------------------- 839
G + Y I + + +N TTG I T+A+
Sbjct: 542 GEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTL 601
Query: 840 ---LDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQN-LPF 895
LDRE+ D R I++ GRP TS+ATV + + D+NDN P F LP
Sbjct: 602 GKALDRESTD-------RYILIITASDGRPD--GTSTATVNIVVTDVNDNAPVFDPYLPR 652
Query: 896 VAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDR 955
V+E A + QV A D D G+NG V Y + G F I +S+G + T +L+R
Sbjct: 653 NLSVVEE-EANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRI-TSNGSIYTAVKLNR 708
Query: 956 ERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVV 1015
E Y+L VVA+D + ST TL I VLD++D +P F + Y V V E++P ++
Sbjct: 709 EVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTIL 768
Query: 1016 WLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVRTVVGLDRET----TAAYMLILE 1071
+ D D+G N +SY I V F++ + + LD E A+ ++E
Sbjct: 769 QIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVE 826
Query: 1072 AIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADE 1131
A D G G ATV V V D+ND P+F + Y+ V D +G I + A DAD
Sbjct: 827 AFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADP 884
Query: 1132 GEF--GRVWYR---ILHGNHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG 1186
RV YR + + F + +G ++ L+ E + L+V A++
Sbjct: 885 PGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVN-LNEEPTTIFKLVVVAFDDGEP 943
Query: 1187 PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNY 1246
M SS V + V E P FTQ++Y + E A GT V V+ A + + Y
Sbjct: 944 VMSSSATVKILVLH-PGEIPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVY 998
Query: 1247 RILSG-AEGKFEIDESTGLIITVNYLDYETKTSYMMNVSA-------TDQAPPFNQGFCS 1298
I+SG E F I+ TG+I LDYET+TSY++ V A + P
Sbjct: 999 SIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAK 1058
Query: 1299 VYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITYRFNAYTST 1356
VYI + +E + F Y + E+ + T ++RV+A D N + + YR
Sbjct: 1059 VYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIK 1118
Query: 1357 QAKALFKIDAITGVITVQGLVDREKGDFYTLTVVA-DDGGPKVDSTVKVYITVLDEND 1413
+ K F ++ TG+I L + ++ V+A DD G + V ++V+++ D
Sbjct: 1119 EGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLD 1176
Score = 265 bits (677), Expect = 6e-70
Identities = 327/1308 (25%), Positives = 553/1308 (42%), Gaps = 185/1308 (14%)
Query: 1896 ERAFFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDN 1955
++ F+N+T R LDR+ P +I V+ N ++ Y + I + D NDN
Sbjct: 91 KQMLFLNST------GRVLDRDP-PMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDN 143
Query: 1956 HPLFTKSTYQAEVMENSPAGTPL-TVLNGPILALDADQDIYAVVTYQLL-----GAQSGL 2009
P F +Y A V E +P GT + T +G A D D + Y + +
Sbjct: 144 SPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDT 203
Query: 2010 FDINSS-TGVVTVRSGVIIDREAFSPPILELLLLAEDIG-LLNSTAHLLITILDDNDNRP 2067
F+I TG + +R + + + I++ A+++ +T L + +LD +D P
Sbjct: 204 FEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263
Query: 2068 TFSPATLTVHLLENCP-----------------PGFSVLQVTATDEDSGLNGE-----LV 2105
F P L + + P P + A D+D + ++
Sbjct: 264 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323
Query: 2106 YRIEAGAQDR----FLIHLVTGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVT 2161
Y I G + F +H T + + ++R+ + + L + A PL A +
Sbjct: 324 YSILVGTPEDYPRFFHMHPRTAELSLLEP-VNRDFHQKFDLVIKAEQDNGHPLPAFAGLH 382
Query: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIAN---------ITAIDHDLNPKLEYHIV 2212
I I D N+ P F P +LESA G I++ I A+D D+
Sbjct: 383 IEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIED------- 435
Query: 2213 GIVAKDDTDRLVPNQEDAFAVNINTGS---VMVKSPMNRELVATYEVTLSVIDNASDLPE 2269
KD L N + TG + + P++RE TY +++ D +
Sbjct: 436 ---TKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP 492
Query: 2270 RSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNG 2329
V++ V+D NDNTP F Y + PG ++I + AVD D+G NG
Sbjct: 493 VIVNI-------QVMDANDNTPTFPEISYDVY---VYTDMRPGDSVIQLTAVDADEGSNG 542
Query: 2330 LVTYTLLD---------------LVPPGY-----------VQLEDS------SAGKVIAN 2357
+TY +L + PG VQ D+ S G +
Sbjct: 543 EITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLG 602
Query: 2358 RTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFEDVPV 2417
+ +D E + ASD G P + V + + D+NDN P+FD + +
Sbjct: 603 KALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEA 661
Query: 2418 GTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKDHYILTALA 2477
+ V ATD D+G + YSLG+ + F I + G IY L+RE +D+Y L +A
Sbjct: 662 NAFVGQVKATDPDAGINGQVHYSLGNFNNLFRIT-SNGSIYTAVKLNREVRDYYELVVVA 720
Query: 2478 KDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQD 2537
D A + R +++ + I+VLD++D P F+ ++ V EN PAGT+++ + A D D
Sbjct: 721 TDG----AVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVD 776
Query: 2538 EGPNGELTYSLEGPGVEAFH-VDMDSGLVTTQRPLQSYEKF-------SLTVVATD--GG 2587
G N ++Y + P V+ F + +G ++ R L YE F + V A D G
Sbjct: 777 LGAN--VSYRIRSPEVKHFFALHPFTGELSLLRSLD-YEAFPDQEASITFLVEAFDIYGT 833
Query: 2588 EPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKDE-GLNG 2646
PP G + V V D+ND PVF + + + + + + VYA D D GL
Sbjct: 834 MPP--GIATVTVIVKDMNDYPPVFSKRIYKGM--VAPDAVKGTPITTVYAEDADPPGLPA 889
Query: 2647 A-VRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETM 2705
+ VRY F ++ SG + T L+ E ++ L++VA D G+PV +
Sbjct: 890 SRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSA 949
Query: 2706 QPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVY 2765
+ L P F + +Y+ V E + +GT+VG ++ A N +
Sbjct: 950 TVKILVLHP--GEIPRFTQE-----EYRPPPVSELATKGTMVGVISAAAI-----NQSIV 997
Query: 2766 YFIAAGNEEKNFHLQP-DGCLLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
Y I +GNEE F + G + V LD E + V+A S L +
Sbjct: 998 YSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLA------NLRVP 1051
Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
+ +V + ++D N+ PP F K Y GV+ DA++ + +++V A D D GN YS
Sbjct: 1052 SKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGN-----YS 1106
Query: 2885 ILAIHYFRALANDSEDVGQVFTMGSMDGILRTFDLFMAYSPGYFVVDIVARD-----LAG 2939
++A +R + ++ + F + + G+++T LF YF ++A D L+G
Sbjct: 1107 VMA---YRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSG 1163
Query: 2940 HNDTAIIGIYILRDDQRVKIVINEIPDRVRGFEEEFIHLL-----SNITGA--IVNTDNV 2992
D + + L D +V IV N P V E+ +L I GA +V +
Sbjct: 1164 KADVLVSVVNQL--DMQV-IVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGA 1220
Query: 2993 QFHVDKKGRVNFAQTELLIHVVNRDTNRILDVDRVIQMIDENKEQLRNLFRNY-----NV 3047
+ H D ++ + +L ++ ++ TNR +D + + + +D + F+ Y +
Sbjct: 1221 RRHGDAFSLEDYTKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRI 1280
Query: 3048 LDVQPAISV----RLPDDMSALQMAIIVLAILLFLA---AMLFVLMNW 3088
L+++ +V + + + + A++ LA ++ L A+L VL+++
Sbjct: 1281 LEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSY 1328
Score = 259 bits (662), Expect = 3e-68
Identities = 298/1093 (27%), Positives = 472/1093 (43%), Gaps = 137/1093 (12%)
Query: 1620 VYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLIT-----IQALDLDEGPNGTVTYAI 1674
V + + D NDN+P F+ Y ++E + T++ T A D+D+GPNG + Y I
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNE-LTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVI 191
Query: 1675 VAG----NIVNTFRIDRHM-GVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTT 1729
+TF I + G I K L+YE RY +I+ A D+ L+ R T+TTT
Sbjct: 192 QYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYE-DKTRYFVIIQANDRAQNLNERRTTTTT 250
Query: 1730 VLVNVNDINDNVPTF-------------PRDYEG--PFEVTEGQPGPRVWT----FLAHD 1770
+ V+V D +D P F P Y+ P T + P + T + D
Sbjct: 251 LTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQD 310
Query: 1771 RDSGPNGQ---VEYSIMDGDPLGE---FVISPVEGVLRVRKDVELDRETIAFYNLTICAR 1824
R+ P + YSI+ G P F + P L + + V +R+ ++L I A
Sbjct: 311 RNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPV--NRDFHQKFDLVIKAE 368
Query: 1825 DRGMPPLSSTMLVGIRVLDINDNDP----------VLLNLPMNITISENSPVSSFVAHVL 1874
PL + + I +LD N+ P +L + P+ TIS++ ++S ++
Sbjct: 369 QDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS-PLRIV 427
Query: 1875 ASDADSGCNARLTFNITAGNRERAFFINAT--TGIVTVNRPLDRERIPEYKLTISVKDNP 1932
A D D ++ + F + T T +T+ +P+DRE Y +I+ D
Sbjct: 428 ALDKDIEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDG- 486
Query: 1933 ENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQ 1992
+ + ++ I + D NDN P F + +Y V + G + L A+DAD+
Sbjct: 487 ----VQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLT----AVDADE 538
Query: 1993 DIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGV--------------------------- 2025
+TY++L G F IN +TG++T+ GV
Sbjct: 539 GSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGI 598
Query: 2026 -----IIDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSP-ATLTVHLL 2079
+DRE+ IL ++ ++ STA + I + D NDN P F P + ++
Sbjct: 599 LTLGKALDRESTDRYIL-IITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVV 657
Query: 2080 ENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATIDREEQES 2139
E F V QV ATD D+G+NG++ Y + L + + ++RE ++
Sbjct: 658 EEEANAF-VGQVKATDPDAGINGQVHYSL---GNFNNLFRITSNGSIYTAVKLNREVRDY 713
Query: 2140 YRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAI 2199
Y L VVATD P T + I + DI+D+ P F N TV V E+ GT I I A
Sbjct: 714 YELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAK 773
Query: 2200 DHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLS 2259
D DL + Y I P + FA++ TG + + ++ E E +++
Sbjct: 774 DVDLGANVSYRIRS-----------PEVKHFFALHPFTGELSLLRSLDYEAFPDQEASIT 822
Query: 2260 VIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVA 2319
+ A D+ ++ A +TV V D+ND P F Y + A GT + V
Sbjct: 823 FLVEAFDI-YGTMPPGIATVTVIVKDMNDYPPVFSK---RIYKGMVAPDAVKGTPITTVY 878
Query: 2320 AVDPD-KGL-NGLVTYTLLDL---VPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRA 2374
A D D GL V Y + D+ P ++E+ S G+VI ++ E V A
Sbjct: 879 AEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDS-GRVITRVNLNEEPTTIFKLVVVA 937
Query: 2375 SDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQ-EAVFEDVPVGTIILTVTATDADSGN 2433
D+G P ++ V + ++ + P F Q Y+ V E GT++ ++A +
Sbjct: 938 FDDGEPVMSSSATVKILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISAAAINQS- 995
Query: 2434 FALIEYSL--GDGESKFAINPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNR--- 2488
I YS+ G+ E F IN TG IYV LD E + Y+L A +A+ R
Sbjct: 996 ---IVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPS 1052
Query: 2489 RENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSL 2548
+ N+ +V I++ D N+ P F K + V E+ TSV+ + ATD+D G + Y L
Sbjct: 1053 KSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRL 1112
Query: 2549 EGP----GVEAFHVDMDSGLVTTQRPLQSYEK--FSLTVVATDGGEPPLWGTTMLLVEVI 2602
P G E F V+ +GL+ T + + F V+ATD L G +LV V+
Sbjct: 1113 IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVV 1172
Query: 2603 DVNDNRPVFVRPP 2615
+ D + + P
Sbjct: 1173 NQLDMQVIVSNVP 1185
Score = 249 bits (635), Expect = 4e-65
Identities = 294/1095 (26%), Positives = 457/1095 (41%), Gaps = 148/1095 (13%)
Query: 113 VITRKVNIQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFI-----VNATDPDLGAGGSV 167
+I +V I V D NDN+PTF ++ Y + E TPVGT IF ATD D G G +
Sbjct: 128 IIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQI 187
Query: 168 LYSFQ-----PPSQ--FFAIDSARGIVTVIRELDYETTQAYQLTVNATD--QDKTRPLST 218
Y Q P S F G + + + L+YE Y + + A D Q+ +T
Sbjct: 188 EYVIQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTT 247
Query: 219 LANLAIIITDVQDMDPIFI------------NLPYSTNIYEHSPPGTTVRIIT-----AI 261
L + + D D+ P+F+ L Y I E P II AI
Sbjct: 248 TTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAI 307
Query: 262 DQDKG------RPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVK 315
DQD+ RP GI Y+I+ G ++ LL+ N + F L +K
Sbjct: 308 DQDRNIQPPSDRP-GILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIK 366
Query: 316 GTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFAL-------- 367
+ N P+ A + +I ++D N+ +P F Y I E A VG +
Sbjct: 367 AEQDNGHPLPAFAGL----HIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTS 422
Query: 368 PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRVAIPLDYETVDRY 427
PL I +DKD + ++L + + F ++ T + + + P+D E Y
Sbjct: 423 PLRIVALDKDIEDTKDPELHLFL-NDYTSVFTVTQTGITR----YLTLLQPVDREEQQTY 477
Query: 428 DFDLFANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDN 487
F + A + V + V I +++ NDN P F + Y++ +Y ++ G SV+ + A D
Sbjct: 478 TFSITAFDGVQESEPVI-VNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
Query: 488 DAGTFGEVSY-FFSDDPDRFSLDKDTGLI-------MLIAR------------------- 520
D G+ GE++Y F ++K TGLI M++ R
Sbjct: 537 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERST 596
Query: 521 --------LDYELIQRFTLTIIARDGGGEET-TGRVRINVLDVNDNVPTFQKDAYVGALR 571
LD E R+ L I A DG + T T V I V DVNDN P F
Sbjct: 597 GILTLGKALDRESTDRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSV 656
Query: 572 ENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEG-YGVISVSRPL-DY 629
E + + +++ATD D+ N Q+ YS+ F + F I+ Y + ++R + DY
Sbjct: 657 VEEEANAFVGQVKATDPDAGINGQVHYSL---GNFNNLFRITSNGSIYTAVKLNREVRDY 713
Query: 630 EQISNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGAT 689
+ L V+A D P +ST+ + I+V D +DN P F+ Y V V EN+ AG T
Sbjct: 714 YE-------LVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTT 766
Query: 690 VLFLNATDLDRSREYGQESIIYSLEGSTQFRINARSGEITTTSLLDRET----KSEYILI 745
+L + A D+D I S E F ++ +GE++ LD E ++ +
Sbjct: 767 ILQIEAKDVDLGANVSYR--IRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFL 824
Query: 746 VRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDP 805
V A D + GIATV + + D+ND P + Y + + +TTV A D
Sbjct: 825 VEAFD--IYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDA 882
Query: 806 D-LGENGTLV-YSIQP-----PNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVV 858
D G + V Y + P + + +G++ T R N + + + +VV
Sbjct: 883 DPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVIT------RVNLNEEPTTIFKLVVV 936
Query: 859 SVTDCGRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLD 918
+ D G P + +SSATV + +L + Q V E G + + A
Sbjct: 937 AFDD-GEPVM--SSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISA---- 989
Query: 919 EGLNGLVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLR-------VVASDAG 971
+N + Y + G F IN+ +GV+ LD E Y LR VV ++
Sbjct: 990 AAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLR 1049
Query: 972 TPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELS 1031
P+KS+T+ + I + D N+ P F Y VSED V+ + TD D G + ++
Sbjct: 1050 VPSKSNTAKVYIEIQDENNHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMA 1109
Query: 1032 YFITGGNVDGKFSVGYRDAVVRTVVGLDRETTAAYML-----ILEAIDNGPVGKRHTGTA 1086
Y + + G VV T GL + + + + I GK +G A
Sbjct: 1110 YRL----IIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKA 1165
Query: 1087 TVFVTVLDVNDNRPI 1101
V V+V++ D + I
Sbjct: 1166 DVLVSVVNQLDMQVI 1180
Score = 244 bits (623), Expect = 1e-63
Identities = 315/1195 (26%), Positives = 502/1195 (42%), Gaps = 179/1195 (14%)
Query: 250 PPGTTVRIITAIDQD-------------KGRPRGIGYTI---VSGNTNSIFALDYISGVL 293
PP T I AID++ KG G TI + N + +D + +L
Sbjct: 39 PPAT----IVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQML 94
Query: 294 TLNG---LLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNS 350
LN +LDR+ P+ H ++ V+ + I+V D NDN+P F
Sbjct: 95 FLNSTGRVLDRDPPMNIHSIVVQVQCINKK-----VGTIIYHEVRIVVRDRNDNSPTFKH 149
Query: 351 SEYSVAITELAQVGFALPLFIQ----VVDKDENLGLNSMFEVYLVGN----NSHHFIISP 402
Y + EL VG + D D+ G N E + N S+ P
Sbjct: 150 ESYYATVNELTPVGTTIFTGFSGDNGATDIDD--GPNGQIEYVIQYNPDDPTSNDTFEIP 207
Query: 403 TSVQGKADIRIRVAIPLDYETVDRYDFDLFANESVPD----HVGYAKVKITLINENDNRP 458
+ G +R R L+YE RY + AN+ + + + +++ +D P
Sbjct: 208 LMLTGNIVLRKR----LNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGP 263
Query: 459 IF-----------SQPL-YNISLYE-------NVTVGTSVLTVLATDNDAGTFGE---VS 496
+F +PL Y ++ E N + T + + D + + +
Sbjct: 264 MFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGIL 323
Query: 497 YFF-----SDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--RVRI 549
Y D P F + T + L+ ++ + Q+F L I A G + I
Sbjct: 324 YSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFAGLHI 383
Query: 550 NVLDVNDNVPTFQKDAYVGALRENEP---------SVTQLVRLRATDEDSPPNNQITYSI 600
+LD N+ P F +Y G + E+ P ++T +R+ A D+D +
Sbjct: 384 EILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHL 443
Query: 601 VSASAFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIE 660
+ + S F ++ +++ +P+D E+ +T + P V V I+
Sbjct: 444 F-LNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP----VIVNIQ 498
Query: 661 VFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ-- 718
V D NDN PTF + +Y V V ++ G +V+ L A D D E I Y + Q
Sbjct: 499 VMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDAD---EGSNGEITYEILVGAQGD 555
Query: 719 FRINARSGEITTT----------------------------------SLLDRETKSEYIL 744
F IN +G IT LDRE+ YIL
Sbjct: 556 FIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYIL 615
Query: 745 IVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKD-APYYINLVEMTPPDSDVTTVVAV 803
I+ A DG T ATVNI + D+NDN P + P +++VE ++ V V A
Sbjct: 616 IITASDG---RPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVE-EEANAFVGQVKAT 671
Query: 804 DPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDC 863
DPD G NG + YS+ N + + S G I T L+RE D +E +VV TD
Sbjct: 672 DPDAGINGQVHYSLGNFNNLFRITSN-GSIYTA-VKLNREVRDYYE------LVVVATDG 723
Query: 864 GRPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNG 923
P +T T+ + +LD++DN P F N + V E +PAG +I Q+ A D+D G N
Sbjct: 724 AVHPRHST--LTLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGTTILQIEAKDVDLGAN- 780
Query: 924 LVSYRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVV----ASDAGTPTKSSTS 979
VSYR+ + F ++ +G + LD E + + + A D +
Sbjct: 781 -VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIA 839
Query: 980 TLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDV-GLNAE-LSYFITGG 1037
T+T+ V D+ND P F +Y V+ D + + + D D GL A + Y +
Sbjct: 840 TVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDV 899
Query: 1038 NVD---GKFSVGYRDAVVRTVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVFVTVL 1093
F V V T V L+ E T + L++ A D+G PV + +ATV + VL
Sbjct: 900 QFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPV---MSSSATVKILVL 956
Query: 1094 DVNDNRPIFLQSSYEAS-VPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRI 1152
+ P F Q Y V E +G + + A ++ + Y I+ GN + F I
Sbjct: 957 HPGEI-PRFTQEEYRPPPVSELATKGTMVGVISAAAINQS----IVYSIVSGNEEDTFGI 1011
Query: 1153 HVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG------PMRSSV-RVIVYVEDINDEA 1205
+ G++ PLD E +S+VL V+A + ++ P +S+ +V + ++D N+
Sbjct: 1012 NNITGVIYVNG-PLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHP 1070
Query: 1206 PVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRIL-----SGAEGKFEIDE 1260
PVF ++ Y G+ E A + TSV+ V+ATD+D+G+ ++ YR++ G EG F ++
Sbjct: 1071 PVFQKKFYIG-GVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEG-FVVET 1128
Query: 1261 STGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDEAVQFSN 1315
TGLI T ++ + V ATD G V ++++N+LD V SN
Sbjct: 1129 YTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSN 1183
Score = 239 bits (610), Expect = 3e-62
Identities = 304/1175 (25%), Positives = 497/1175 (42%), Gaps = 183/1175 (15%)
Query: 1403 KVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVAT-----VKAWDPDAGSNGQVVFS 1457
+V I V D NDNSP F S A ++ E PVG + T A D D G NGQ+ +
Sbjct: 132 EVRIVVRDRNDNSPTFKHESYYA-TVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1458 LASGNIAGAFEIVTTNDSI-------GEVFVARPLDREELDHYILQVVASDRG---TPPR 1507
+ + T+ND+ G + + + L+ E+ Y + + A+DR R
Sbjct: 191 IQYNP-----DDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERR 245
Query: 1508 KKDHILQVTILDINDNPPVIE-----------SPFGYNVSV-----NENVGGGTAVVQVR 1551
L V +LD +D P+ P Y ++ E + ++
Sbjct: 246 TTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQ 305
Query: 1552 ATDRDIGINSV-----LSYYITEGNKD---MAFRMDRISGEIATRPAPPDRERQSFYHLV 1603
A D+D I + Y I G + F M + E++ P +R+ + LV
Sbjct: 306 AIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLL-EPVNRDFHQKFDLV 364
Query: 1604 ATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYE-VLLDEGP------DTLN-TSLI 1655
E + L A +++ I+DEN+ +P F P Y+ +L+ P D+LN TS +
Sbjct: 365 IKAEQDNGHPLPAFAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 1656 TIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGV---ITAAKELDYEISHGRYTLIVT 1712
I ALD D + + + F + + G+ +T + +D E YT +T
Sbjct: 425 RIVALDKDIEDTKDPELHLFLNDYTSVFTVTQ-TGITRYLTLLQPVDRE-EQQTYTFSIT 482
Query: 1713 ATDQCPILSHRLTSTTTVLVNVN--DINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHD 1770
A D + + V+VN+ D NDN PTFP + T+ +PG V A D
Sbjct: 483 AFD-------GVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVD 535
Query: 1771 RDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVE---------------------- 1808
D G NG++ Y I+ G G+F+I+ G++ + VE
Sbjct: 536 ADEGSNGEITYEILVG-AQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAER 594
Query: 1809 ----------LDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVL-LNLPMN 1857
LDRE+ Y L I A D G P +ST V I V D+NDN PV LP N
Sbjct: 595 STGILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVFDPYLPRN 653
Query: 1858 ITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPLDRE 1917
+++ E ++FV V A+D D+G N ++ +++ GN F I + I T + L+RE
Sbjct: 654 LSVVEEE-ANAFVGQVKATDPDAGINGQVHYSL--GNFNNLFRITSNGSIYTAVK-LNRE 709
Query: 1918 RIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTP 1977
Y+L + D +PR + L I + D +DN P+FT STY V EN PAGT
Sbjct: 710 VRDYYELVVVATDGAVHPRHSTL---TLAIKVLDIDDNSPVFTNSTYTVLVEENLPAGT- 765
Query: 1978 LTVLNGPILALDA-DQDIYAVVTYQLLGAQ-SGLFDINSSTGVVTVRSGVIIDREAFSPP 2035
IL ++A D D+ A V+Y++ + F ++ TG +++ +D EAF
Sbjct: 766 ------TILQIEAKDVDLGANVSYRIRSPEVKHFFALHPFTGELSLLRS--LDYEAFPDQ 817
Query: 2036 ILELLLLAEDIGLLNS----TAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQV 2091
+ L E + + A + + + D ND P FS + + G + V
Sbjct: 818 EASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTV 877
Query: 2092 TATDED-SGLNGELV-YRIE----AGAQDRFLIHLVTGVIRVGNATIDREEQESYRLTVV 2145
A D D GL V YR++ F + +G + + ++ E ++L VV
Sbjct: 878 YAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRV-ITRVNLNEEPTTIFKLVVV 936
Query: 2146 ATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNP 2205
A D G +S +A V IL+ + + V E A GT++ I+A +N
Sbjct: 937 AFDDGEPVMSSSATVKILVLHPGEIPRFTQEEYRPPPVSELATKGTMVGVISAA--AINQ 994
Query: 2206 KLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVTLSVIDNAS 2265
+ Y IV N+ED F +N TG + V P++ E +Y L V ++
Sbjct: 995 SIVYSIVS-----------GNEEDTFGINNITGVIYVNGPLDYETRTSY--VLRVQADSL 1041
Query: 2266 DLPERSVSVPN----AKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAV 2321
++ ++ VP+ AK+ + + D N++ P F+ +Y+ + E A T+++ V A
Sbjct: 1042 EVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK---KFYIGGVSEDARMFTSVLRVKAT 1098
Query: 2322 DPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEV--------HWLNFTVR 2373
D D G ++ Y L ++PP +++ G V+ T + + F V
Sbjct: 1099 DKDTGNYSVMAYRL--IIPP----IKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVI 1152
Query: 2374 ASDNGSPPRAAEIPVYLEIVDINDNNPIFDQ--PSYQEAVFED------------VPVGT 2419
A+D+ + + V + +V+ D I P+ E ED +P
Sbjct: 1153 ATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAK 1212
Query: 2420 IILTVTATDADSGNFALIEYSLGDGESKFAINPTT 2454
+++ F+L +Y+ D + +AI+P T
Sbjct: 1213 VVVESIGARRHGDAFSLEDYTKCD-LTVYAIDPQT 1246
Score = 230 bits (587), Expect = 2e-59
Identities = 283/1081 (26%), Positives = 460/1081 (42%), Gaps = 173/1081 (16%)
Query: 1730 VLVNVNDINDNVPTFPRD--YEGPFEVTEGQPGPRVWTFLAHDR-----DSGPNGQVEYS 1782
V + V D NDN PTF + Y E+T G ++T + D D GPNGQ+EY
Sbjct: 133 VRIVVRDRNDNSPTFKHESYYATVNELTP--VGTTIFTGFSGDNGATDIDDGPNGQIEYV 190
Query: 1783 IM--DGDPLGEFVIS---PVEGVLRVRKDVELDRETIAFYNLTICARDRGM---PPLSST 1834
I DP + G + +RK + + +T F + I A DR ++T
Sbjct: 191 IQYNPDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYF--VIIQANDRAQNLNERRTTT 248
Query: 1835 MLVGIRVLDINDNDPVLLN------------------LPMNITISENSPVSSFVAHVLAS 1876
+ + VLD +D P+ L +P T E +P+ + A
Sbjct: 249 TTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPII-VTPPIQAI 307
Query: 1877 DADSGCNAR-----LTFNITAGNRE---RAFFINATTGIVTVNRPLDRERIPEYKLTISV 1928
D D + ++I G E R F ++ T +++ P++R+ ++ L I
Sbjct: 308 DQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKA 367
Query: 1929 KDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAEVMENSPAGTPLTV---LNGPI 1985
+ + +P A + L I + DEN+ P FT +YQ ++E++P G ++ L P+
Sbjct: 368 EQDNGHPLPA---FAGLHIEILDENNQSPYFTMPSYQGYILESAPVGATISDSLNLTSPL 424
Query: 1986 LALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTV-RSGVI--------IDREAFSPPI 2036
+ D+DI +L LF +N T V TV ++G+ +DRE
Sbjct: 425 RIVALDKDIEDTKDPEL-----HLF-LNDYTSVFTVTQTGITRYLTLLQPVDRE--EQQT 476
Query: 2037 LELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVHLLENCPPGFSVLQVTATDE 2096
+ A D + + I ++D NDN PTF + V++ + PG SV+Q+TA D
Sbjct: 477 YTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDA 536
Query: 2097 DSGLNGELVYRIEAGAQDRFLIHLVTGVIRVG---------------------------- 2128
D G NGE+ Y I GAQ F+I+ TG+I +
Sbjct: 537 DEGSNGEITYEILVGAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERST 596
Query: 2129 -----NATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPI--QTV 2181
+DRE + Y L + A+D G + TA V I++ D+ND+ P F +P + +
Sbjct: 597 GILTLGKALDRESTDRYILIITASD-GRPDGTSTATVNIVVTDVNDNAPVF-DPYLPRNL 654
Query: 2182 SVLESAEPGTVIANITAIDHD--LNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGS 2239
SV+E E + + A D D +N ++ Y + N + F + N GS
Sbjct: 655 SVVEE-EANAFVGQVKATDPDAGINGQVHYSL-------------GNFNNLFRITSN-GS 699
Query: 2240 VMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGIT 2299
+ +NRE+ YE+ + D A P S L + VLD++DN+P F T
Sbjct: 700 IYTAVKLNREVRDYYELVVVATDGAVH-PRHS----TLTLAIKVLDIDDNSPVFTNSTYT 754
Query: 2300 YYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRT 2359
+E E GTT++ + A D D G N V+Y + + L + G++ R+
Sbjct: 755 VLVE---ENLPAGTTILQIEAKDVDLGAN--VSYRIRSPEVKHFFALHPFT-GELSLLRS 808
Query: 2360 VDYE----EVHWLNFTVRASD--NGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQEAVFE 2413
+DYE + + F V A D PP A + V ++ D+ND P+F + Y+ V
Sbjct: 809 LDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVK--DMNDYPPVFSKRIYKGMVAP 866
Query: 2414 DVPVGTIILTVTATDADSGNF--ALIEYSLGDGE-----SKFAINPTTGDIYVLSSLDRE 2466
D GT I TV A DAD + + Y + D + S F + +G + +L+ E
Sbjct: 867 DAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQFPYPASIFEVEEDSGRVITRVNLNEE 926
Query: 2467 KKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGT 2526
+ L +A D+ V S +S V I VL + P+F+ Y P
Sbjct: 927 PTTIFKLVVVAFDDGEPVMS----SSATVKILVLHPGEI------PRFTQEEYRPPPVSE 976
Query: 2527 SVI--TMMATDQDEGPNGELTYSL-EGPGVEAFHVDMDSGLVTTQRPLQ-----SY---- 2574
TM+ N + YS+ G + F ++ +G++ PL SY
Sbjct: 977 LATKGTMVGVISAAAINQSIVYSIVSGNEEDTFGINNITGVIYVNGPLDYETRTSYVLRV 1036
Query: 2575 EKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYE 2634
+ SL VV + P T + +E+ D N++ PVF + I + E+ + ++V
Sbjct: 1037 QADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPPVFQK--KFYIGGVSEDARMFTSVLR 1094
Query: 2635 VYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS 2694
V ATDKD G + Y + E F+++ +GLI+TA ++ + ++A+
Sbjct: 1095 VKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIAT 1154
Query: 2695 D 2695
D
Sbjct: 1155 D 1155
Score = 224 bits (570), Expect = 1e-57
Identities = 271/1049 (25%), Positives = 447/1049 (42%), Gaps = 127/1049 (12%)
Query: 983 IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVW-----LNCTDNDVGLNAELSYFITGG 1037
I V D ND +PTF Y +V+E P + TD D G N ++ Y I
Sbjct: 135 IVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYN 194
Query: 1038 NVDGKFSVGYRDAVVRT--VV---GLDRETTAAYMLILEAIDNGP-VGKRHTGTATVFVT 1091
D + + ++ T +V L+ E Y +I++A D + +R T T T+ V
Sbjct: 195 PDDPTSNDTFEIPLMLTGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVD 254
Query: 1092 VLDVNDNRPIFLQS------------SYEASVPE-DIPEGHSIL----QLKATDADEG-- 1132
VLD +D P+FL +Y+A++PE PE + + ++A D D
Sbjct: 255 VLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQ 314
Query: 1133 ---EFGRVWYRILHG---NHGNNFRIHVSNGLLMRGPRPLDRERNSSHVLIVEAYNHDLG 1186
+ + Y IL G ++ F +H L P++R+ + L+++A +
Sbjct: 315 PPSDRPGILYSILVGTPEDYPRFFHMHPRTAELSL-LEPVNRDFHQKFDLVIKAEQDNGH 373
Query: 1187 PMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIG---------TSVIVVQATDRD 1237
P+ + + + + D N+++P FT Y L E+A +G TS + + A D+D
Sbjct: 374 PLPAFAGLHIEILDENNQSPYFTMPSYQGYIL-ESAPVGATISDSLNLTSPLRIVALDKD 432
Query: 1238 SGDGGLVNYRI-LSGAEGKFEIDES--TGLIITVNYLDYETKTSYMMNVSATDQAPPFNQ 1294
D + L+ F + ++ T + + +D E + +Y +++A D
Sbjct: 433 IEDTKDPELHLFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITAFDGVQESEP 492
Query: 1295 GFCSVYITLLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSID--NLNQITY---- 1348
++ + N D F SY+ + ++ G ++++ A D + +ITY
Sbjct: 493 VIVNIQVMDAN--DNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILV 550
Query: 1349 --------------------------RFNAYTSTQAKALFKIDAITGVITVQGLVDREKG 1382
R A T A + TG++T+ +DRE
Sbjct: 551 GAQGDFIINKTTGLITIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDREST 610
Query: 1383 DFYTLTVVADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVK 1442
D Y L + A DG P ST V I V D NDN+P FD +S+ E+ V VK
Sbjct: 611 DRYILIITASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEE-EANAFVGQVK 669
Query: 1443 AWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDR 1502
A DPDAG NGQV +SL GN F I S G ++ A L+RE D+Y L VVA+D
Sbjct: 670 ATDPDAGINGQVHYSL--GNFNNLFRIT----SNGSIYTAVKLNREVRDYYELVVVATDG 723
Query: 1503 GTPPRKKDHILQVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSV 1562
PR L + +LDI+DN PV + Y V V EN+ GT ++Q+ A D D+G N
Sbjct: 724 AVHPRHSTLTLAIKVLDIDDNSPVFTNS-TYTVLVEENLPAGTTILQIEAKDVDLGAN-- 780
Query: 1563 LSYYITEGNKDMAFRMDRISGEIA-----TRPAPPDRERQSFYHLVATVEDEGTPTLSAT 1617
+SY I F + +GE++ A PD+E S LV + GT
Sbjct: 781 VSYRIRSPEVKHFFALHPFTGELSLLRSLDYEAFPDQE-ASITFLVEAFDIYGTMPPGIA 839
Query: 1618 THVYVTIVDENDNAPMFQQPHYEVLLDEGPDTL-NTSLITIQALDLDEG--PNGTVTYAI 1674
T V V + D ND P+F + Y+ ++ PD + T + T+ A D D P V Y +
Sbjct: 840 T-VTVIVKDMNDYPPVFSKRIYKGMV--APDAVKGTPITTVYAEDADPPGLPASRVRYRV 896
Query: 1675 VAGNI---VNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVL 1731
+ F ++ G + L+ E + ++V D P++S S+ TV
Sbjct: 897 DDVQFPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMS----SSATVK 952
Query: 1732 VNVNDINDNVPTFPRDYEGPFEVTE-GQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLG 1790
+ V + +P F ++ P V+E G V A + N + YSI+ G+
Sbjct: 953 ILVLHPGE-IPRFTQEEYRPPPVSELATKGTMVGVISA----AAINQSIVYSIVSGNEED 1007
Query: 1791 EFVISPVEGVLRVRKDVELDRET-----IAFYNLTICARDRGMPPLSSTMLVGIRVLDIN 1845
F I+ + GV+ V ++ + T + +L + + +P S+T V I + D N
Sbjct: 1008 TFGINNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDEN 1067
Query: 1846 DNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNI---TAGNRERAFFIN 1902
++ PV +SE++ + + V V A+D D+G + + + + + F +
Sbjct: 1068 NHPPVFQKKFYIGGVSEDARMFTSVLRVKATDKDTGNYSVMAYRLIIPPIKEGKEGFVVE 1127
Query: 1903 ATTGIVTVNRPLDRERIPEYKLTISVKDN 1931
TG++ R +K + D+
Sbjct: 1128 TYTGLIKTAMLFHNMRRSYFKFQVIATDD 1156
Score = 191 bits (484), Expect = 1e-47
Identities = 217/830 (26%), Positives = 353/830 (42%), Gaps = 126/830 (15%)
Query: 26 NRLPFFTNHFFDTYLLISEDTPVGSSVT---------QLLAQDMD----NDPLVFGVSGE 72
N+ P+FT + Y+L E PVG++++ +++A D D DP + +
Sbjct: 390 NQSPYFTMPSYQGYIL--ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELHLFLND 447
Query: 73 EASRFFAVEPD-TGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRK---VNIQVGDVNDN 128
S F + T + L QP+DRE + +T FS++ GV + VNIQV D NDN
Sbjct: 448 YTSVFTVTQTGITRYLTLLQPVDREEQQTYT--FSITAFDGVQESEPVIVNIQVMDANDN 505
Query: 129 APTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQ-FFAIDSARGIV 187
PTF Y V + + G + + A D D G+ G + Y +Q F I+ G++
Sbjct: 506 TPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQGDFIINKTTGLI 565
Query: 188 TVIRELDYETTQAYQLTVNATDQDKTRPLST----------------------------- 218
T+ ++ + Y LTV A D ST
Sbjct: 566 TIAPGVEMIVGRTYALTVQAADNAPPAERSTGILTLGKALDRESTDRYILIITASDGRPD 625
Query: 219 ---LANLAIIITDVQDMDPIF-INLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYT 274
A + I++TDV D P+F LP + ++ E V + A D D G + Y+
Sbjct: 626 GTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEE-ANAFVGQVKATDPDAGINGQVHYS 684
Query: 275 IVSGNTNSIFALDYISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTF 334
+ GN N++F + + T L+RE Y ++ G P +T+T
Sbjct: 685 L--GNFNNLFRITSNGSIYTA-VKLNREVRDYYELVVVATDGAV-----HPRHSTLTLA- 735
Query: 335 NILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNN 394
I V+DI+DN+P F +S Y+V + E G + +Q+ KD +LG N + +
Sbjct: 736 -IKVLDIDDNSPVFTNSTYTVLVEENLPAGTTI---LQIEAKDVDLGANVSYRI-RSPEV 790
Query: 395 SHHFIISPTSVQGKADIRIRVAIPLDYETVDRYD---------FDLFANESVPDHVGYAK 445
H F + P + + + + LDYE + FD++ ++P G A
Sbjct: 791 KHFFALHPFTGE------LSLLRSLDYEAFPDQEASITFLVEAFDIYG--TMPP--GIAT 840
Query: 446 VKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTF--GEVSYFFSD-- 501
V + + + ND P+FS+ +Y + + GT + TV A D D V Y D
Sbjct: 841 VTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGLPASRVRYRVDDVQ 900
Query: 502 ---DPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVN-DN 557
F +++D+G ++ L+ E F L ++A D G + + +L ++
Sbjct: 901 FPYPASIFEVEEDSGRVITRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVKILVLHPGE 960
Query: 558 VPTFQKDAYVGALRENEPSVTQLV---RLRATDEDSPPNNQITYSIVSASAFGSYFDISL 614
+P F ++ Y P V++L + + N I YSIVS + ++ +
Sbjct: 961 IPRFTQEEY------RPPPVSELATKGTMVGVISAAAINQSIVYSIVSGNEEDTF---GI 1011
Query: 615 YEGYGVISVSRPLDYEQISNGLI-----YLTVMAMDAGNPPLNSTVPVTIEVFDENDNPP 669
GVI V+ PLDYE ++ ++ L V+ + P ++T V IE+ DEN++PP
Sbjct: 1012 NNITGVIYVNGPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENNHPP 1071
Query: 670 TFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESII-YSL------EGSTQFRIN 722
F K Y V E+ +VL + ATD D G S++ Y L EG F +
Sbjct: 1072 VFQKKFYIGGVSEDARMFTSVLRVKATDKDT----GNYSVMAYRLIIPPIKEGKEGFVVE 1127
Query: 723 ARSGEITTTSLLDRETKSEYILIVRAVDG-GVGHNQKTGIATVNITLLDI 771
+G I T L +S + V A D G G + K + + LD+
Sbjct: 1128 TYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDM 1177
Score = 89.0 bits (219), Expect = 7e-17
Identities = 130/542 (23%), Positives = 218/542 (40%), Gaps = 92/542 (16%)
Query: 2405 PSYQEAVFEDVPVGTIIL-TVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSL 2463
P+ A+ E+ GTI++ + G IE SL D + + + L+S
Sbjct: 40 PATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLMDPVKQMLFLNST 99
Query: 2464 DREKKDHYILTALAKDNPGDVAS--------NRRENSV---QVVIQVLDVNDCRPQFSKP 2512
R L +D P ++ S N++ ++ +V I V D ND P F
Sbjct: 100 GR---------VLDRDPPMNIHSIVVQVQCINKKVGTIIYHEVRIVVRDRNDNSPTFKHE 150
Query: 2513 QFSTSVYENEPAGTSVITMM-----ATDQDEGPNGELTYSLE-----GPGVEAFHVD-MD 2561
+ +V E P GT++ T ATD D+GPNG++ Y ++ + F + M
Sbjct: 151 SYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPDDPTSNDTFEIPLML 210
Query: 2562 SGLVTTQRPLQSYEK--FSLTVVATDGGE---PPLWGTTMLLVEVIDVNDNRPVF---VR 2613
+G + ++ L +K + + + A D + TT L V+V+D +D P+F V
Sbjct: 211 TGNIVLRKRLNYEDKTRYFVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVL 270
Query: 2614 PPN----------GTILHIREEIPLRSNVYE--VYATDKDEGLNG-----AVRYSFLKTA 2656
PN I +R L + + A D+D + + YS L
Sbjct: 271 VPNTRDCRPLTYQAAIPELRTPEELNPIIVTPPIQAIDQDRNIQPPSDRPGILYSILVGT 330
Query: 2657 GNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVAS-DLGQPVPYETMQPLQVALEDI 2715
FF + P + + + ++R+ + L++ A D G P+P L + + D
Sbjct: 331 PEDYPRFFHMHPRTAELSLLEPVNRDFHQKFDLVIKAEQDNGHPLP--AFAGLHIEILDE 388
Query: 2716 DDNEPLFVRPPKGSPQYQLLTVPEHSPRGTLVG---NVTG-----AVDADEGPNAIVYYF 2767
++ P F P S Q +L E +P G + N+T A+D D
Sbjct: 389 NNQSPYFTMP---SYQGYIL---ESAPVGATISDSLNLTSPLRIVALDKDIEDTKDPELH 442
Query: 2768 IAAGNEEKNFHLQPDGC---LLVLRDLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLV 2824
+ + F + G L +L+ +DRE + ++F + A D V
Sbjct: 443 LFLNDYTSVFTVTQTGITRYLTLLQPVDREEQQTYTFSITA---------------FDGV 487
Query: 2825 ADLTLQEVRVVLEDINDQPPRFTKAEYTAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
+ V + + D ND P F + Y V TD + G +IQ+ A+DAD G+N + Y
Sbjct: 488 QESEPVIVNIQVMDANDNTPTFPEISYDVYVYTDMRPGDSVIQLTAVDADEGSNGEITYE 547
Query: 2885 IL 2886
IL
Sbjct: 548 IL 549
>gi|16933565 protocadherin 21 precursor [Homo sapiens]
Length = 859
Score = 281 bits (719), Expect = 8e-75
Identities = 235/720 (32%), Positives = 349/720 (48%), Gaps = 62/720 (8%)
Query: 12 AWLLVLISGCWGQVNRLPFFTNHFFDT----------YLLISEDTPVGSSVTQLLAQDMD 61
A L L+ C Q N F HFFD + EDTPVGS V L D +
Sbjct: 8 ALALGLLRLCLAQAN----FAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE 63
Query: 62 NDPLVFGVSGEEASR-FFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNI 120
DP+ + +S + ++R F+V+P G + L + LDRE + E S+SD ++ KV I
Sbjct: 64 GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAEKVVI 123
Query: 121 QVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQPPSQFFAI 180
V D ND AP F +PY +PE+ P G+ IF V+A D D G+GGSV Y Q FA+
Sbjct: 124 LVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSPFAV 183
Query: 181 DSARGIVTVI--RELDYETTQAYQLTVNATD-----QDKTRPLSTLANLAIIITDVQDMD 233
D G++ + LDYE ++ + +TV A D S + + + DVQDM
Sbjct: 184 DRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMA 243
Query: 234 PIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVL 293
P+F+ PY +YE + PG+ V + A+D D+G+P I Y++V+GN + F ++ SG +
Sbjct: 244 PVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAI 302
Query: 294 TLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF----- 348
++ L + L V+ TE++ +P+ A T I ++D+N++ P F
Sbjct: 303 SIT---QSPAQLQREVYELHVQVTEMSPAGSPA-AQATVPVTIRIVDLNNHPPTFYGESG 358
Query: 349 NSSEYSVAITELAQVGFAL-PLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQG 407
+ + +++ E G L L I V D D+ G N+ F + LVG F + P +V
Sbjct: 359 PQNRFELSMNEHPPQGEILRGLKITVNDSDQ--GANAKFNLQLVGPRG-IFRVVPQTVLN 415
Query: 408 KADIRIRV--AIPLDYETVDRYDFDLFANE-SVPDHV-GYAKVKITLINENDNRPIFSQP 463
+A + I V + +D+E F L A E + P+ A V I L++ NDN P F
Sbjct: 416 EAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSL 475
Query: 464 LYNISLYENVTVGTSVLTVLATDNDAGTFGEVSY-FFSDDPDRFSLDKDTGLIML--IAR 520
Y + EN G+SV+ V A D D G +GEV Y + D F + TGLI A
Sbjct: 476 YYVARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWAS 535
Query: 521 LDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQL 580
LD E R+ + A D G+ + V I +LDVND+ P F K + P
Sbjct: 536 LDAEATARYNFYVKAEDMEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP----- 590
Query: 581 VRLRATDEDS-PPNNQITYSIVSASAFGSYFDISLYEGYGVISVS-RPLD-YEQISNG-- 635
V++ A DED+ PNN + YSI A + FDI+ + G + S R LD I+ G
Sbjct: 591 VKIEAIDEDAEEPNNLVDYSITHAEP-ANVFDINSHTGEIWLKNSIRSLDALHNITPGRD 649
Query: 636 -LIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSK---PAYFVSVVENIMAGATVL 691
L L V A D G+P ++T + I++ D T S+ A+ + +N M VL
Sbjct: 650 CLWSLEVQAKDRGSPSFSTTALLKIDITDAE----TLSRSPMAAFLIQTKDNPMKAVGVL 705
Score = 173 bits (439), Expect = 2e-42
Identities = 168/586 (28%), Positives = 254/586 (43%), Gaps = 49/586 (8%)
Query: 454 NDNRPIFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDPDR---FSLDK 510
N N +FS P E+ VG+ V T+ TD + +SY S DP FS+D
Sbjct: 36 NGNMALFSLP-------EDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSVDP 85
Query: 511 DTGLIMLIARLDYELIQRFTLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGAL 570
G I L+ LD E II+ G +V I V D ND P F ++ YV +
Sbjct: 86 TFGNITLVEELDREREDEIE-AIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALV 144
Query: 571 RENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYE 630
E+ P+ + + ++ A D D+ +TY + + S F + + G + LDYE
Sbjct: 145 PEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH---SPFAVDRHSGVLRLQAGATLDYE 201
Query: 631 QISNGLIYLTVMAMDAG------NPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENI 684
+ Y+TV+A D G + ++T VT+ V D D P F Y+ V E+
Sbjct: 202 RSRTH--YITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDT 259
Query: 685 MAGATVLFLNATDLDRSREYGQESIIYSLEGSTQ--FRINARSGEITTT---SLLDRETK 739
+ G+ VL + A D DR + I+YSL F IN SG I+ T + L RE
Sbjct: 260 LPGSEVLKVVAMDGDRGKP---NRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVY 316
Query: 740 SEYILIVRAVDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMT----PPDS 795
++ + G Q T V I ++D+N++ PT+ N E++ PP
Sbjct: 317 ELHVQVTEMSPAGSPAAQAT--VPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQG 374
Query: 796 DVTTVVAV---DPDLGENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAEL 852
++ + + D D G N + P + + T + + EN + E
Sbjct: 375 EILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQT-VLNEAQVTIIVENSAAIDFEK 433
Query: 853 MRKIVVSVTDCG-RPPLKATSSATVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQ 911
+ + + P K +S+A V + LLD NDN P F +L +VA + E P G S+
Sbjct: 434 SKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVA 493
Query: 912 VVAIDLDEGLNGLVSYRMPVGMPRMDFLINSSSGVVVTT--TELDRERIAEYQLRVVASD 969
V A+D D G G V Y G FLI+ S+G++ T LD E A Y V A D
Sbjct: 494 VTAVDPDTGPWGEVKY-STYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED 552
Query: 970 AGTPTKSSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVV 1015
K S + + I +LDVND P F +V ++ P + +
Sbjct: 553 --MEGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTPVKIEAI 596
Score = 169 bits (428), Expect = 4e-41
Identities = 190/664 (28%), Positives = 290/664 (43%), Gaps = 68/664 (10%)
Query: 1003 SVSEDVPREFRVVWLNCTDNDVGLNAELSYFIT-GGNVDGKFSVGYRDAVVRTVVGLDRE 1061
S+ ED P V LN TD + +SY I+ + FSV + V LDRE
Sbjct: 43 SLPEDTPVGSHVYTLNGTDPE---GDPISYHISFDPSTRSVFSVDPTFGNITLVEELDRE 99
Query: 1062 TTAAYMLILEAIDNGPVGKRHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSI 1121
I+ D + V + V D ND P F+Q Y A VPEDIP G I
Sbjct: 100 REDEIEAIISISDG-----LNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAGSII 154
Query: 1122 LQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLL-MRGPRPLDRERNSSHVLIVEA 1180
++ A D D G G V Y + N + F + +G+L ++ LD ER+ +H + V A
Sbjct: 155 FKVHAVDRDTGSGGSVTYFL--QNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYITVVA 212
Query: 1181 YN-----HDLGPMRS-SVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQAT 1234
+ H + S + V V VED+ D APVF Y +T G+ V+ V A
Sbjct: 213 KDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLP-GSEVLKVVAM 271
Query: 1235 DRDSGDGGLVNYRILSGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAP---P 1291
D D G + Y +++G +G FEI+E++G I + Y ++V T+ +P P
Sbjct: 272 DGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQVTEMSPAGSP 331
Query: 1292 FNQGFCSVYITLLNELDEAVQFSNAS-----YEAAILENLALGTEIVRVQAYSIDNLNQ- 1345
Q V I +++ + F S +E ++ E+ G EI+R ++++ +Q
Sbjct: 332 AAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQG-EILRGLKITVNDSDQG 390
Query: 1346 ITYRFNAYTSTQAKALFKI--------DAITGVITVQGLVDREKGDFYTLTVVADDGG-- 1395
+FN + +F++ +T ++ +D EK T ++A +
Sbjct: 391 ANAKFNLQL-VGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTP 449
Query: 1396 PKVDSTVKVYITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVV 1455
K ST V I +LD NDN P+FD + IPE+ P G V V A DPD G G+V
Sbjct: 450 EKFSSTADVVIQLLDTNDNVPKFD-SLYYVARIPENAPGGSSVVAVTAVDPDTGPWGEVK 508
Query: 1456 FSLASGNIAGAFEIVTTNDSIGEVFVA--RPLDREELDHYILQVVASDRGTPPRKKDHIL 1513
+S G A F I + S G ++ LD E Y V A D K +
Sbjct: 509 YS-TYGTGADLFLI---HPSTGLIYTQPWASLDAEATARYNFYVKAEDM----EGKYSVA 560
Query: 1514 QV--TILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDI-GINSVLSYYITEG 1570
+V T+LD+ND+PP FG +V V G V++ A D D N+++ Y IT
Sbjct: 561 EVFITLLDVNDHPP----QFGKSVQKKTMVLG--TPVKIEAIDEDAEEPNNLVDYSITHA 614
Query: 1571 NKDMAFRMDRISGEIATRPAPPDRE--------RQSFYHLVATVEDEGTPTLSATTHVYV 1622
F ++ +GEI + + + R + L +D G+P+ S T + +
Sbjct: 615 EPANVFDINSHTGEIWLKNSIRSLDALHNITPGRDCLWSLEVQAKDRGSPSFSTTALLKI 674
Query: 1623 TIVD 1626
I D
Sbjct: 675 DITD 678
Score = 167 bits (424), Expect = 1e-40
Identities = 164/599 (27%), Positives = 269/599 (44%), Gaps = 54/599 (9%)
Query: 1681 NTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDN 1740
+ F +D G IT +ELD E I++ +D +++ + V++ V D ND
Sbjct: 79 SVFSVDPTFGNITLVEELDRE-REDEIEAIISISDGLNLVAEK------VVILVTDANDE 131
Query: 1741 VPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGV 1800
P F ++ + G ++ A DRD+G G V Y + + F + GV
Sbjct: 132 APRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH--SPFAVDRHSGV 189
Query: 1801 LRVRKDVELDRETIAFYNLTICARDRGMP------PLSSTMLVGIRVLDINDNDPVLLNL 1854
LR++ LD E + +T+ A+D G S+T V + V D+ D PV +
Sbjct: 190 LRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGT 249
Query: 1855 PMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTGIVTVNRPL 1914
P + E++ S V V+A D D G R+ +++ GN + AF IN T+G +++ +
Sbjct: 250 PYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINETSGAISITQSP 308
Query: 1915 DRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLF-----TKSTYQAEVM 1969
+ + Y+L + V + A + + I + D N++ P F ++ ++ +
Sbjct: 309 AQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMN 368
Query: 1970 ENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVIIDR 2029
E+ P G L L I D+DQ A QL+G + G+F + T + + +I++
Sbjct: 369 EHPPQGEILRGLK--ITVNDSDQGANAKFNLQLVGPR-GIFRVVPQTVLNEAQVTIIVEN 425
Query: 2030 EAF----SPPILELLLLAEDIGL---LNSTAHLLITILDDNDNRPTFSPATLTVHLLENC 2082
A +L LLA ++ +STA ++I +LD NDN P F + EN
Sbjct: 426 SAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENA 485
Query: 2083 PPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGN-ATIDREEQESYR 2141
P G SV+ VTA D D+G GE+ Y D FLIH TG+I A++D E Y
Sbjct: 486 PGGSSVVAVTAVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYN 545
Query: 2142 LTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDH 2201
V A D +T+L D+ND P+F +Q +++ GT + I AID
Sbjct: 546 FYVKAEDMEGKYSVAEVFITLL--DVNDHPPQFGKSVQKKTMV----LGTPV-KIEAIDE 598
Query: 2202 DL---NPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKSPMNRELVATYEVT 2257
D N ++Y I + F +N +TG + +K+ + R L A + +T
Sbjct: 599 DAEEPNNLVDYSITH-----------AEPANVFDINSHTGEIWLKNSI-RSLDALHNIT 645
Score = 161 bits (407), Expect = 1e-38
Identities = 178/634 (28%), Positives = 281/634 (44%), Gaps = 64/634 (10%)
Query: 569 ALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLD 628
+L E+ P + + L TD + P I+Y I + S F + +G I++ LD
Sbjct: 43 SLPEDTPVGSHVYTLNGTDPEGDP---ISYHISFDPSTRSVFSVD--PTFGNITLVEELD 97
Query: 629 YEQISNGLIYLTVMAMDAGNPPLNSTVP-VTIEVFDENDNPPTFSKPAYFVSVVENIMAG 687
E+ + A+ + + LN V I V D ND P F + Y V E+I AG
Sbjct: 98 REREDE------IEAIISISDGLNLVAEKVVILVTDANDEAPRFIQEPYVALVPEDIPAG 151
Query: 688 ATVLFLNATDLDRSREYGQESIIYSLEG-STQFRINARSG--EITTTSLLDRE-TKSEYI 743
+ + ++A D D S+ Y L+ + F ++ SG + + LD E +++ YI
Sbjct: 152 SIIFKVHAVDRDTG---SGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERSRTHYI 208
Query: 744 LIVRAVDGGVGHNQK---TGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTV 800
+V GG H + TV + + D+ D P + PYY + E T P S+V V
Sbjct: 209 TVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYGYVYEDTLPGSEVLKV 268
Query: 801 VAVDPDLGENGTLVYSIQPPNK-FYSLNSTTGKIRTTH--AMLDRENPDPHEAELMRKIV 857
VA+D D G+ ++YS+ N + +N T+G I T A L RE + H V
Sbjct: 269 VAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHVQ------V 322
Query: 858 VSVTDCGRPPLKATSSATVFVNLLDLNDNDPTF------QNLPFVAEVLEGIPAGVSI-- 909
++ G P +AT T+ ++DLN++ PTF QN F + E P G +
Sbjct: 323 TEMSPAGSPAAQATVPVTI--RIVDLNNHPPTFYGESGPQNR-FELSMNEHPPQGEILRG 379
Query: 910 YQVVAIDLDEGLNGLVSYRM--PVGMPRM--DFLINSSSGVVVT--TTELDRERIAEYQL 963
++ D D+G N + ++ P G+ R+ ++N + ++ + +D E+
Sbjct: 380 LKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTF 439
Query: 964 RVVASDAGTPTK-SSTSTLTIHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDN 1022
+++A + TP K SST+ + I +LD ND P F Y + E+ P VV + D
Sbjct: 440 KLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVTAVDP 499
Query: 1023 DVGLNAELSYFITGGNVDGKFSVGYRDAVVRTV--VGLDRETTAAYMLILEAIDNGPVGK 1080
D G E+ Y G D F + ++ T LD E TA Y ++A D +
Sbjct: 500 DTGPWGEVKYSTYGTGAD-LFLIHPSTGLIYTQPWASLDAEATARYNFYVKAEDM----E 554
Query: 1081 RHTGTATVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGR-VWY 1139
A VF+T+LDVND+ P F +S + ++ P ++++A D D E V Y
Sbjct: 555 GKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVLGTP-----VKIEAIDEDAEEPNNLVDY 609
Query: 1140 RILHGNHGNNFRI--HVSNGLLMRGPRPLDRERN 1171
I H N F I H L R LD N
Sbjct: 610 SITHAEPANVFDINSHTGEIWLKNSIRSLDALHN 643
Score = 160 bits (405), Expect = 2e-38
Identities = 147/524 (28%), Positives = 234/524 (44%), Gaps = 59/524 (11%)
Query: 2388 VYLEIVDINDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESK 2447
V + + D ND P F Q Y V ED+P G+II V A D D+G+ + Y L + S
Sbjct: 121 VVILVTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP 180
Query: 2448 FAINPTTGDIYVLS--SLDREKKDHYILTALAKDNPGDV--ASNRRENSVQVVIQVLDVN 2503
FA++ +G + + + +LD E+ + +T +AKD G + A + V + V DV
Sbjct: 181 FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQ 240
Query: 2504 DCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSG 2563
D P F + VYE+ G+ V+ ++A D D G + YSL AF ++ SG
Sbjct: 241 DMAPVFVGTPYYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSG 300
Query: 2564 LVT-TQRPLQ-SYEKFSLTVVATD---GGEPPLWGTTMLLVEVIDVNDNRPVFVR---PP 2615
++ TQ P Q E + L V T+ G P T + + ++D+N++ P F P
Sbjct: 301 AISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQ 360
Query: 2616 NGTILHIREEIPLRSNV--YEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDP----- 2668
N L + E P + ++ D D+G N + G F + P
Sbjct: 361 NRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRG-----IFRVVPQTVLN 415
Query: 2669 ---ISGLIQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRP 2725
++ +++ + +D E V + L+A ++ P + + + + L D +DN P F
Sbjct: 416 EAQVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKF--- 472
Query: 2726 PKGSPQYQLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCL 2785
Y + +PE++P G+ V VT AVD D GP V Y G F + P L
Sbjct: 473 ---DSLYYVARIPENAPGGSSVVAVT-AVDPDTGPWGEVKYS-TYGTGADLFLIHPSTGL 527
Query: 2786 LVLR---DLDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQ 2842
+ + LD E A ++F VKA D+ ++ EV + L D+ND
Sbjct: 528 IYTQPWASLDAEATARYNFYVKAE---------------DMEGKYSVAEVFITLLDVNDH 572
Query: 2843 PPRFTKAEYTAGVATDAKVGSELIQVLALDADIGN-NSLVFYSI 2885
PP+F K+ V V +++ A+D D N+LV YSI
Sbjct: 573 PPQFGKS-----VQKKTMVLGTPVKIEAIDEDAEEPNNLVDYSI 611
Score = 159 bits (402), Expect = 4e-38
Identities = 168/589 (28%), Positives = 259/589 (43%), Gaps = 56/589 (9%)
Query: 1346 ITYRFNAYTSTQAKALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVY 1405
I+Y + ST +++F +D G IT+ +DRE+ D + DG V KV
Sbjct: 67 ISYHISFDPST--RSVFSVDPTFGNITLVEELDREREDEIEAIISISDGLNLVAE--KVV 122
Query: 1406 ITVLDENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAG 1465
I V D ND +PRF +PED P G + V A D D GS G V + L N+
Sbjct: 123 ILVTDANDEAPRF-IQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQ--NLHS 179
Query: 1466 AFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVT------ILD 1519
F V + + + LD E + + VVA D G D + T + D
Sbjct: 180 PFA-VDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVED 238
Query: 1520 INDNPPV-IESPF-GYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKDMAFR 1577
+ D PV + +P+ GY V E+ G+ V++V A D D G + + Y + GN D AF
Sbjct: 239 VQDMAPVFVGTPYYGY---VYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFE 294
Query: 1578 MDRISGEIATRPAPPDRERQSF--YHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMF- 1634
++ SG I+ +P +R+ + + V + G+P AT V + IVD N++ P F
Sbjct: 295 INETSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFY 354
Query: 1635 ----QQPHYEVLLDEGP---DTLNTSLITIQALDLDEGPNGTVT---------YAIVAGN 1678
Q +E+ ++E P + L IT+ D D+G N + +V
Sbjct: 355 GESGPQNRFELSMNEHPPQGEILRGLKITVN--DSDQGANAKFNLQLVGPRGIFRVVPQT 412
Query: 1679 IVNTFRIDRHMGVITAAKELDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDIN 1738
++N ++ ++ + +D+E S ++ P + +ST V++ + D N
Sbjct: 413 VLNEAQVTI---IVENSAAIDFEKSKVLTFKLLAVEVNTP---EKFSSTADVVIQLLDTN 466
Query: 1739 DNVPTFPRDYEGPFEVTEGQP-GPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPV 1797
DNVP F Y + E P G V A D D+GP G+V+YS G F+I P
Sbjct: 467 DNVPKFDSLYY-VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYSTY-GTGADLFLIHPS 524
Query: 1798 EGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDNDPVLLNLPMN 1857
G++ + LD E A YN + A D M S V I +LD+ND+ P
Sbjct: 525 TGLIYTQPWASLDAEATARYNFYVKAED--MEGKYSVAEVFITLLDVNDHPPQFGKSVQK 582
Query: 1858 ITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFFINATTG 1906
T+ +PV + DA+ N + ++IT F IN+ TG
Sbjct: 583 KTMVLGTPVK---IEAIDEDAEEP-NNLVDYSITHAEPANVFDINSHTG 627
Score = 158 bits (400), Expect = 8e-38
Identities = 178/696 (25%), Positives = 285/696 (40%), Gaps = 65/696 (9%)
Query: 1185 LGPMRSSVRVIVYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLV 1244
LG +R + + D T + L E +G+ V + TD + G +
Sbjct: 11 LGLLRLCLAQANFAPHFFDNGVGSTNGNMALFSLPEDTPVGSHVYTLNGTDPE---GDPI 67
Query: 1245 NYRIL--SGAEGKFEIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYIT 1302
+Y I F +D + G I V LD E + +S +D N V I
Sbjct: 68 SYHISFDPSTRSVFSVDPTFGNITLVEELDREREDEIEAIISISDG---LNLVAEKVVIL 124
Query: 1303 LLNELDEAVQFSNASYEAAILENLALGTEIVRVQAYSIDNLN--QITYRFNAYTSTQAKA 1360
+ + DEA +F Y A + E++ G+ I +V A D + +TY S
Sbjct: 125 VTDANDEAPRFIQEPYVALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLHSP---- 180
Query: 1361 LFKIDAITGVITVQG--LVDREKGDFYTLTVVADDGGPKV-------DSTVKVYITVLDE 1411
F +D +GV+ +Q +D E+ + +TVVA DGG ++ +T V + V D
Sbjct: 181 -FAVDRHSGVLRLQAGATLDYERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDV 239
Query: 1412 NDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVT 1471
D +P F T + ED G V V A D D G ++++SL +GN GAFEI
Sbjct: 240 QDMAPVFVGTPYYGY-VYEDTLPGSEVLKVVAMDGDRGKPNRILYSLVNGN-DGAFEINE 297
Query: 1472 TNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPF 1531
T+ +I L RE + ++ S G+P + + + I+D+N++PP
Sbjct: 298 TSGAISITQSPAQLQREVYELHVQVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGES 357
Query: 1532 G----YNVSVNENVGGGTAV--VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGE- 1584
G + +S+NE+ G + +++ D D G N+ + + + E
Sbjct: 358 GPQNRFELSMNEHPPQGEILRGLKITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEA 417
Query: 1585 ----IATRPAPPDRERQSFYHLVATVEDEGTPT-LSATTHVYVTIVDENDNAPMFQQPHY 1639
I A D E+ + TP S+T V + ++D NDN P F +Y
Sbjct: 418 QVTIIVENSAAIDFEKSKVLTFKLLAVEVNTPEKFSSTADVVIQLLDTNDNVPKFDSLYY 477
Query: 1640 EVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAK--E 1697
+ E +S++ + A+D D GP G V Y+ G + F I G+I
Sbjct: 478 VARIPENAPG-GSSVVAVTAVDPDTGPWGEVKYSTY-GTGADLFLIHPSTGLIYTQPWAS 535
Query: 1698 LDYEISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTFPRDYEGPFEVTEG 1757
LD E + RY V A D S V + + D+ND+ P F + + V
Sbjct: 536 LDAEAT-ARYNFYVKAEDM-----EGKYSVAEVFITLLDVNDHPPQFGKSVQKKTMVL-- 587
Query: 1758 QPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFY 1817
G V + PN V+YSI +P F I+ G + ++ + R A +
Sbjct: 588 --GTPVKIEAIDEDAEEPNNLVDYSITHAEPANVFDINSHTGEIWLKNSI---RSLDALH 642
Query: 1818 NLT----------ICARDRGMPPLSSTMLVGIRVLD 1843
N+T + A+DRG P S+T L+ I + D
Sbjct: 643 NITPGRDCLWSLEVQAKDRGSPSFSTTALLKIDITD 678
Score = 154 bits (388), Expect = 2e-36
Identities = 180/717 (25%), Positives = 298/717 (41%), Gaps = 87/717 (12%)
Query: 2078 LLENCPPGFSVLQVTATDEDSGLNGELVYRIEAGAQDRFLIHLVTGVIRVGNATI----D 2133
L E+ P G V + TD + + Y I R + + GN T+ D
Sbjct: 44 LPEDTPVGSHVYTLNGTDPEGD---PISYHISFDPSTRSVFSVDP---TFGNITLVEELD 97
Query: 2134 REEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTVI 2193
RE ++ + +D + V IL+ D ND P F+ V E G++I
Sbjct: 98 REREDEIEAIISISDGLNLVAEK---VVILVTDANDEAPRFIQEPYVALVPEDIPAGSII 154
Query: 2194 ANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVKS--PMNRELV 2251
+ A+D D + + N FAV+ ++G + +++ ++ E
Sbjct: 155 FKVHAVDRDTG-----------SGGSVTYFLQNLHSPFAVDRHSGVLRLQAGATLDYERS 203
Query: 2252 ATYEVTLSVIDNASDLPERSVSVP-NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGAT 2310
T+ +T+ D L V +TVNV DV D P F G YY + E
Sbjct: 204 RTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVF--VGTPYY-GYVYEDTL 260
Query: 2311 PGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNF 2370
PG+ ++ V A+D D+G + Y+L++ + E S A + + EV+ L+
Sbjct: 261 PGSEVLKVVAMDGDRGKPNRILYSLVNGNDGAFEINETSGAISITQSPAQLQREVYELHV 320
Query: 2371 TV-RASDNGSPPRAAEIPVYLEIVDINDNNPIF-----DQPSYQEAVFEDVPVGTII--L 2422
V S GSP A +PV + IVD+N++ P F Q ++ ++ E P G I+ L
Sbjct: 321 QVTEMSPAGSPAAQATVPVTIRIVDLNNHPPTFYGESGPQNRFELSMNEHPPQGEILRGL 380
Query: 2423 TVTATDADSGNFALIEYSLGDGESKFAINPTT----GDIYVL----SSLDREKKD--HYI 2472
+T D+D G A L F + P T + ++ +++D EK +
Sbjct: 381 KITVNDSDQGANAKFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAIDFEKSKVLTFK 440
Query: 2473 LTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMM 2532
L A+ + P +S + VVIQ+LD ND P+F + + EN P G+SV+ +
Sbjct: 441 LLAVEVNTPEKFSS-----TADVVIQLLDTNDNVPKFDSLYYVARIPENAPGGSSVVAVT 495
Query: 2533 ATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQ----RPLQSYEKFSLTVVATDGGE 2588
A D D GP GE+ YS G G + F + +GL+ TQ ++ +++ V A D
Sbjct: 496 AVDPDTGPWGEVKYSTYGTGADLFLIHPSTGLIYTQPWASLDAEATARYNFYVKAED--M 553
Query: 2589 PPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIPLRSNVYEVYATDKD-EGLNGA 2647
+ + + ++DVND+ P F + ++++ + ++ A D+D E N
Sbjct: 554 EGKYSVAEVFITLLDVNDHPPQFGK-------SVQKKTMVLGTPVKIEAIDEDAEEPNNL 606
Query: 2648 VRYSFLKT-------AGNRDWEFFIIDPISGLIQTAQRLDRESQAVYSLILVASDLGQPV 2700
V YS + E ++ + I L + ++SL + A D G P
Sbjct: 607 VDYSITHAEPANVFDINSHTGEIWLKNSIRSL-DALHNITPGRDCLWSLEVQAKDRGSP- 664
Query: 2701 PYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLLTVPEHSPR---GTLVGNVTGAV 2754
+ T L++ DI D E L SP L + +P G L G + V
Sbjct: 665 SFSTTALLKI---DITDAETL-----SRSPMAAFLIQTKDNPMKAVGVLAGTMATVV 713
Score = 143 bits (361), Expect = 2e-33
Identities = 147/513 (28%), Positives = 228/513 (44%), Gaps = 62/513 (12%)
Query: 2396 NDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTG 2455
N N +F P ED PVG+ + T+ TD + + S F+++PT G
Sbjct: 36 NGNMALFSLP-------EDTPVGSHVYTLNGTDPEGDPISYHISFDPSTRSVFSVDPTFG 88
Query: 2456 DIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFS 2515
+I ++ LDRE++D D VA +VVI V D ND P+F + +
Sbjct: 89 NITLVEELDREREDEIEAIISISDGLNLVAE-------KVVILVTDANDEAPRFIQEPYV 141
Query: 2516 TSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDSGLVTTQRPLQ-SY 2574
V E+ PAG+ + + A D+D G G +TY L+ F VD SG++ Q Y
Sbjct: 142 ALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH-SPFAVDRHSGVLRLQAGATLDY 200
Query: 2575 EKFS---LTVVATDGG------EPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREE 2625
E+ +TVVA DGG + TT + V V DV D PVFV P ++ E+
Sbjct: 201 ERSRTHYITVVAKDGGGRLHGADVVFSATTTVTVNVEDVQDMAPVFVGTPYYG--YVYED 258
Query: 2626 IPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQ---RLDRE 2682
S V +V A D D G + YS + N + F I+ SG I Q +L RE
Sbjct: 259 TLPGSEVLKVVAMDGDRGKPNRILYSLV----NGNDGAFEINETSGAISITQSPAQLQRE 314
Query: 2683 SQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQL-LTVPEHS 2741
++ + S G P T+ P+ + + D++++ P F + PQ + L++ EH
Sbjct: 315 VYELHVQVTEMSPAGSPAAQATV-PVTIRIVDLNNHPPTFYG--ESGPQNRFELSMNEHP 371
Query: 2742 PRGTLVGNVTGAV-DADEGPNAIVYYFIAAGNEEKNFHLQPDGCL------LVLRD---L 2791
P+G ++ + V D+D+G NA + + F + P L +++ + +
Sbjct: 372 PQGEILRGLKITVNDSDQGANA--KFNLQLVGPRGIFRVVPQTVLNEAQVTIIVENSAAI 429
Query: 2792 DREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEY 2851
D E+ + +F + A + P S T D+V L D ND P+F Y
Sbjct: 430 DFEKSKVLTFKLLAVEVNT---PEKFSSTADVVIQLL---------DTNDNVPKFDSLYY 477
Query: 2852 TAGVATDAKVGSELIQVLALDADIGNNSLVFYS 2884
A + +A GS ++ V A+D D G V YS
Sbjct: 478 VARIPENAPGGSSVVAVTAVDPDTGPWGEVKYS 510
Score = 76.6 bits (187), Expect = 4e-13
Identities = 74/276 (26%), Positives = 116/276 (42%), Gaps = 32/276 (11%)
Query: 2616 NGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQT 2675
N + + E+ P+ S+VY + TD + + Y R F +DP G I
Sbjct: 38 NMALFSLPEDTPVGSHVYTLNGTDPE---GDPISYHISFDPSTRS--VFSVDPTFGNITL 92
Query: 2676 AQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQLL 2735
+ LDRE + I+ SD V + + + + D +D P F++ P +
Sbjct: 93 VEELDREREDEIEAIISISDGLNLVAEKVV----ILVTDANDEAPRFIQEP------YVA 142
Query: 2736 TVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPDGCLLVLR-----D 2790
VPE P G+++ V AVD D G V YF+ N F + +L L+ D
Sbjct: 143 LVPEDIPAGSIIFKVH-AVDRDTGSGGSVTYFLQ--NLHSPFAVDRHSGVLRLQAGATLD 199
Query: 2791 LDREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAE 2850
+R R + + K R D+V T V V +ED+ D P F
Sbjct: 200 YERSRTHYITVVAKDGGGRLHGA--------DVVFSATTT-VTVNVEDVQDMAPVFVGTP 250
Query: 2851 YTAGVATDAKVGSELIQVLALDADIGNNSLVFYSIL 2886
Y V D GSE+++V+A+D D G + + YS++
Sbjct: 251 YYGYVYEDTLPGSEVLKVVAMDGDRGKPNRILYSLV 286
Score = 59.3 bits (142), Expect = 6e-08
Identities = 46/157 (29%), Positives = 74/157 (47%), Gaps = 20/157 (12%)
Query: 2734 LLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQPD-GCLLVLRDLD 2792
L ++PE +P G+ V + G D + I Y+ + F + P G + ++ +LD
Sbjct: 41 LFSLPEDTPVGSHVYTLNGT---DPEGDPISYHISFDPSTRSVFSVDPTFGNITLVEELD 97
Query: 2793 REREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYT 2852
RERE I+ S L+LVA+ +V +++ D ND+ PRF + Y
Sbjct: 98 REREDEIEAIISISDG------------LNLVAE----KVVILVTDANDEAPRFIQEPYV 141
Query: 2853 AGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIH 2889
A V D GS + +V A+D D G+ V Y + +H
Sbjct: 142 ALVPEDIPAGSIIFKVHAVDRDTGSGGSVTYFLQNLH 178
>gi|27754773 protocadherin 1 isoform 2 precursor [Homo sapiens]
Length = 1237
Score = 265 bits (678), Expect = 4e-70
Identities = 215/701 (30%), Positives = 323/701 (46%), Gaps = 62/701 (8%)
Query: 1732 VNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGE 1791
+ V DINDN P F G LA DRD+GPNG Y + G E
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 1792 FVISPVEGVLRVRKDVE-----------LDRETIAFYNLTICARDRGMPPLSSTMLVGIR 1840
L+V +D E LDRE Y+LTI +D G PP +S+ L+ +
Sbjct: 216 LF------GLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269
Query: 1841 VLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL--TFNITAGNRERA 1898
VLD NDN P +SENSP+ V V A+D+D G NA + TF+ R
Sbjct: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329
Query: 1899 FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHP- 1957
++ TG++TV P+DRE + + ++ KD NP+ AR +++ + D NDN P
Sbjct: 330 LRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQ---VVVTVKDMNDNAPT 386
Query: 1958 -------LFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLF 2010
L T A + E+ T + ++ D D+ A VT + G
Sbjct: 387 IEIRGIGLVTHQDGMANISEDVAEETAVALVQ----VSDRDEGENAAVTCVVAGDVPFQL 442
Query: 2011 DINSSTGVVTVRSGVI-----IDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDN 2065
S TG + + + +D E +E++ + L+ST L + ++D NDN
Sbjct: 443 RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502
Query: 2066 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEA--GAQDRFLIHLVTG 2123
P F+ + V EN PG + ++TA+D DSG N ELVY +E A+ F I TG
Sbjct: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562
Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
I+V ++DRE++ESY L VVA DRG+ L GTA V + + D ND+ P+F+ SV
Sbjct: 563 EIQV-KTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV 621
Query: 2184 LESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVK 2243
+E+ + + +T ID D + + V +D+ D F + TG+++
Sbjct: 622 MENMPALSPVGMVTVIDGDKGENAQVQL--SVEQDNGD---------FVIQNGTGTILSS 670
Query: 2244 SPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYME 2303
+RE +TY L +D +P RS V +T+NVLD NDN P T +
Sbjct: 671 LSFDREQQSTYTFQLKAVDGG--VPPRSAYV---GVTINVLDENDNAPYITAPSNTSH-- 723
Query: 2304 RILEGATP-GTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDY 2362
++L T G T+ VAA D D G+N + Y++ P G Q+ S +G + + ++
Sbjct: 724 KLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQI-GSHSGAITLEKEIER 782
Query: 2363 EEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFD 2403
V+ SD G PPR V+L + + N + +
Sbjct: 783 RHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLE 823
Score = 261 bits (667), Expect = 8e-69
Identities = 226/779 (29%), Positives = 347/779 (44%), Gaps = 72/779 (9%)
Query: 247 EHSPPGTTVRIITAIDQDKGRPR---------GIGYTIVSGNTNSIFALDYISGVLTLNG 297
E PP T + + A D G P G Y V G T IF + + G
Sbjct: 66 EEQPPNTLIGSLAA---DYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETS---IDREG 119
Query: 298 LLDRENPLYSHGFILT--VKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSV 355
L + +N L IL V T+L + +P I V DINDN P F S ++
Sbjct: 120 LRECQNQLPGDPCILEFEVSITDLVQNGSPR----LLEGQIEVQDINDNTPNFASPVITL 175
Query: 356 AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRV 415
AI E +G P+ + D+D + +E+ F + Q + ++ V
Sbjct: 176 AIPENTNIGSLFPIPL-ASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIV 234
Query: 416 AIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVT 474
LD E D YD + + P A +++T+++ NDN P F +P Y L EN
Sbjct: 235 MGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSP 294
Query: 475 VGTSVLTVLATDNDAGTFGEVSYFFSDDPD----RFSLDKDTGLIMLIARLDYELIQRFT 530
+G SV+ V A D+D G E+ Y F P+ LD++TGLI + +D E +
Sbjct: 295 IGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLR 354
Query: 531 LTIIARDGGGEETTGR--VRINVLDVNDNVPTFQ--------KDAYVGALRENEPSVTQL 580
+++A+D G + R V + V D+NDN PT + + + E+ T +
Sbjct: 355 FSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAV 414
Query: 581 VRLRATDEDSPPNNQIT--------YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQI 632
++ +D D N +T + + AS GS + + + PLDYE++
Sbjct: 415 ALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYF-----LQTTTPLDYEKV 469
Query: 633 SNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLF 692
+ I ++A+D+GNPPL+ST + ++V D NDN P F++ V+ EN G +
Sbjct: 470 KDYTI--EIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAE 527
Query: 693 LNATDLDRSREYGQESIIYSLE----GSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748
+ A+D D ++YSLE F I+ +GEI + LDRE + Y L V A
Sbjct: 528 ITASDADSG---SNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVA 584
Query: 749 VDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLG 808
D G Q G ATV + +LD NDN P + + Y +++E P S V V +D D G
Sbjct: 585 ADRGSPSLQ--GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 642
Query: 809 ENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPL 868
EN + S++ N + + + TG I ++ DRE + +L D G PP
Sbjct: 643 ENAQVQLSVEQDNGDFVIQNGTGTILSS-LSFDREQQSTYTFQL------KAVDGGVPPR 695
Query: 869 KATSSATVFVNLLDLNDNDPTFQNLPFVAEVL--EGIPAGVSIYQVVAIDLDEGLNGLVS 926
A T +N+LD NDN P + L G ++ QV A D D G+N +
Sbjct: 696 SAYVGVT--INVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELI 753
Query: 927 YRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHV 985
Y + G P F I S SG + E++R ++L V SD G P + T+ + ++V
Sbjct: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
Score = 256 bits (653), Expect = 3e-67
Identities = 211/682 (30%), Positives = 321/682 (47%), Gaps = 51/682 (7%)
Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
Q+ + DINDN P SP +++ EN G+ A+DRD G N V SY + G +
Sbjct: 155 QIEVQDINDNTPNFASPV-ITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEA 213
Query: 1574 MA-FRMDRISGEIATRP-----APPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDE 1627
F + + +P DRER Y L V+D G+P +++ + VT++D
Sbjct: 214 QELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273
Query: 1628 NDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAI-VAGNIVNTF-RI 1685
NDNAP F++P YE L E + S+I ++A D D+G N + Y A +V R+
Sbjct: 274 NDNAPKFERPSYEAELSEN-SPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332
Query: 1686 DRHMGVITAAKELDYE-ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTF 1744
DR+ G+IT +D E +S R++++ P ++ V+V V D+NDN PT
Sbjct: 333 DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNP-----KSARAQVVVTVKDMNDNAPTI 387
Query: 1745 P-------RDYEGPFEVTEGQPGPRVWTFL-AHDRDSGPN--------GQVEYSIMDGDP 1788
+G ++E + DRD G N G V + +
Sbjct: 388 EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447
Query: 1789 LGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDND 1848
G S + ++ LD E + Y + I A D G PPLSST + ++V+D+NDN
Sbjct: 448 TG----SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
Query: 1849 PVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFF-INATTGI 1907
PV + EN+ +A + ASDADSG NA L +++ + F I+ TG
Sbjct: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
Query: 1908 VTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAE 1967
+ V LDRE+ Y+L + D +P + + +L+ + D NDN P F S Y
Sbjct: 564 IQVKTSLDREQRESYELKVVAADR-GSPSL--QGTATVLVNVLDCNDNDPKFMLSGYNFS 620
Query: 1968 VMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII 2027
VMEN PA +P+ G + +D D+ A V + +G F I + TG T+ S +
Sbjct: 621 VMENMPALSPV----GMVTVIDGDKGENAQVQLS-VEQDNGDFVIQNGTG--TILSSLSF 673
Query: 2028 DREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVH--LLENCPPG 2085
DRE S +L + + ++ + I +LD+NDN P + + T H L G
Sbjct: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLG 733
Query: 2086 FSVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTV 2144
+V QV A D DSG+N EL+Y I G F I +G I + I+R +RL V
Sbjct: 734 ETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITL-EKEIERRHHGLHRLVV 792
Query: 2145 VATDRGTVPLSGTAIVTILIDD 2166
+DRG P GTA+V + +++
Sbjct: 793 KVSDRGKPPRYGTALVHLYVNE 814
Score = 253 bits (646), Expect = 2e-66
Identities = 213/701 (30%), Positives = 322/701 (45%), Gaps = 52/701 (7%)
Query: 1196 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK 1255
+ V+DIND P F + L + E IG+ + A+DRD+G G+ +Y + +G E +
Sbjct: 156 IEVQDINDNTPNFASPVIT-LAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 1256 F--------EIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNEL 1307
+ +E +I + LD E SY + + D P + +T+L+
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274
Query: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKID 1365
D A +F SYEA + EN +G +++V+A D +I Y F+ + L ++D
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV-VRRLLRLD 333
Query: 1366 AITGVITVQGLVDREKGDFYTLTVVADDGGPKVDST-VKVYITVLDENDNSPRFDFTS-- 1422
TG+ITVQG VDRE +V+A D G S +V +TV D NDN+P +
Sbjct: 334 RNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIG 393
Query: 1423 -----DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASG---NIAGAFEIVTTND 1474
D +I ED VA V+ D D G N V +A + A E T +D
Sbjct: 394 LVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE--TGSD 451
Query: 1475 SIGEVFV--ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFG 1532
S + F+ PLD E++ Y +++VA D G PP + L+V ++D+NDN PV
Sbjct: 452 SKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVT 511
Query: 1533 YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT-EGNKDMAFRMDRISGEIATRPAP 1591
V+ EN G + ++ A+D D G N+ L Y + E F + +GEI + +
Sbjct: 512 -EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL 570
Query: 1592 PDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLN 1651
DRE++ Y L D G+P+L T V V ++D NDN P F Y + E L+
Sbjct: 571 -DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALS 629
Query: 1652 -TSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLI 1710
++T+ +D D+G N V ++ N F I G I ++ D E YT
Sbjct: 630 PVGMVTV--IDGDKGENAQVQLSVEQDN--GDFVIQNGTGTILSSLSFDRE-QQSTYTFQ 684
Query: 1711 VTATDQ-CPILSHRLTSTTTVLVNVNDINDNVP--TFPRDYEGPFEVTEGQPGPRVWTFL 1767
+ A D P S + V +NV D NDN P T P + + + G V
Sbjct: 685 LKAVDGGVPPRS----AYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVA 740
Query: 1768 AHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1827
A D DSG N ++ YSI G+P G F I G + + K++E R + L + DRG
Sbjct: 741 AEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE--RRHHGLHRLVVKVSDRG 798
Query: 1828 MPPLSSTMLVGIRVLDINDNDPVL-------LNLPMNITIS 1861
PP T LV + V + N +L L+ P++I I+
Sbjct: 799 KPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIA 839
Score = 252 bits (644), Expect = 4e-66
Identities = 235/801 (29%), Positives = 345/801 (43%), Gaps = 80/801 (9%)
Query: 927 YRMPVGMPRMDFLINSSSGVVVTT-TELDRERIAEYQLRVVASDAGTPTKSSTSTLT--- 982
Y++ VG P + ++ +G + TT T +DRE + E Q ++ + S + L
Sbjct: 90 YKLEVGAPYLR--VDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNG 147
Query: 983 --------IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1034
I V D+ND TP F V +++ E+ +D D G N SY +
Sbjct: 148 SPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYEL 207
Query: 1035 TGGNVDGKFSVGYRDAVVRT-------VVG-LDRETTAAYMLILEAIDNGPVGKRHTGTA 1086
G + + G + A + V+G LDRE +Y L ++ D G + +A
Sbjct: 208 QAGP-EAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPR--ASSA 264
Query: 1087 TVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNH 1146
+ VTVLD NDN P F + SYEA + E+ P GHS++Q+KA D+D+G + Y
Sbjct: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324
Query: 1147 --GNNFRIHVSNGLL-MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDIND 1203
R+ + GL+ ++GP +DRE S+ V A + P + +V+V V+D+ND
Sbjct: 325 VVRRLLRLDRNTGLITVQGP--VDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND 382
Query: 1204 EAPVF-------TQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKF 1256
AP Q + E T+V +VQ +DRD G+ V + +
Sbjct: 383 NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQL 442
Query: 1257 EIDESTG-------LIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDE 1309
TG + T LDYE Y + + A D P S+ + +++ D
Sbjct: 443 RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502
Query: 1310 AVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITG 1369
A F+ + E A EN G I + A D+ + ++ AK LF I TG
Sbjct: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562
Query: 1370 VITVQGLVDREKGDFYTLTVV-ADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSI 1428
I V+ +DRE+ + Y L VV AD G P + T V + VLD NDN P+F S S+
Sbjct: 563 EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF-MLSGYNFSV 621
Query: 1429 PEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE 1488
E+ P V V D D G N QV S+ N G F I + G + + DRE
Sbjct: 622 MENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN--GDFVI---QNGTGTILSSLSFDRE 676
Query: 1489 ELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVS-VNENVGGGTAV 1547
+ Y Q+ A D G PPR + + +LD NDN P I +P + + G V
Sbjct: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETV 736
Query: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVE 1607
QV A D D G+N+ L Y I GN F++ SG I T +R + LV V
Sbjct: 737 SQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAI-TLEKEIERRHHGLHRLVVKVS 795
Query: 1608 DEGTPTL--SATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLD-- 1663
D G P +A H+YV N + + E LL DT LD+D
Sbjct: 796 DRGKPPRYGTALVHLYV-------NETLANRTLLETLLGHSLDT---------PLDIDIA 839
Query: 1664 -------EGPNGTVTYAIVAG 1677
G + + +VAG
Sbjct: 840 GDPEYERSKQRGNILFGVVAG 860
Score = 230 bits (587), Expect = 2e-59
Identities = 194/691 (28%), Positives = 305/691 (44%), Gaps = 35/691 (5%)
Query: 530 TLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDED 589
++T + ++G G++ + D+NDN P F A+ EN + A+D D
Sbjct: 139 SITDLVQNGSPRLLEGQIEVQ--DINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD 196
Query: 590 SPPNNQITYSIVSASAFGSYFDISLYEGYGV----ISVSRPLDYEQISNGLIYLTVMAMD 645
+ PN +Y + + F + + E + V LD E+ + LT+ D
Sbjct: 197 AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDS--YDLTIKVQD 254
Query: 646 AGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYG 705
G+PP S+ + + V D NDN P F +P+Y + EN G +V+ + A D D+
Sbjct: 255 GGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAE 314
Query: 706 QESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIAT 763
E + + R++ +G IT +DRE S V A D G N K+ A
Sbjct: 315 IEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT--NPKSARAQ 372
Query: 764 VNITLLDINDNHPTWKDAPYYI--------NLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
V +T+ D+NDN PT + + N+ E ++ V V D D GEN +
Sbjct: 373 VVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTC 432
Query: 816 SIQPPNKFYSLN-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
+ F S TG L P +E I + D G PPL +T+S
Sbjct: 433 VVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSL 492
Query: 875 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-PVGM 933
V V +D+NDN P F E G I ++ A D D G N + Y + P
Sbjct: 493 KVQV--VDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA 550
Query: 934 PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETP 993
+ F I+ +G + T LDRE+ Y+L+VVA+D G+P+ T+T+ ++VLD ND P
Sbjct: 551 AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDP 610
Query: 994 TFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVR 1053
F + YN SV E++P V + D D G NA++ + N G F + +
Sbjct: 611 KFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN--GDFVIQNGTGTIL 668
Query: 1054 TVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVFVTVLDVNDNRPIFL---QSSYEA 1109
+ + DRE + Y L+A+D G P + G V + VLD NDN P +S++
Sbjct: 669 SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG---VTINVLDENDNAPYITAPSNTSHKL 725
Query: 1110 SVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRE 1169
P+ G ++ Q+ A D D G + Y I GN F+I +G + + ++R
Sbjct: 726 LTPQ-TRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITL-EKEIERR 783
Query: 1170 RNSSHVLIVEAYNHDLGPMRSSVRVIVYVED 1200
+ H L+V+ + P + V +YV +
Sbjct: 784 HHGLHRLVVKVSDRGKPPRYGTALVHLYVNE 814
Score = 228 bits (581), Expect = 8e-59
Identities = 211/707 (29%), Positives = 329/707 (46%), Gaps = 66/707 (9%)
Query: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTD 2221
I + DIND+ P F +P+ T+++ E+ G++ A D D P G+ + +
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPN------GVASYEL-- 207
Query: 2222 RLVPNQEDAFAVNI------NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2275
+ P ++ F + + ++V ++RE +Y++T+ V D S P R+ S
Sbjct: 208 QAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGS--PPRASS-- 263
Query: 2276 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 2335
A L V VLD NDN P+F+ Y + E + G ++I V A D D+G N + YT
Sbjct: 264 -ALLRVTVLDTNDNAPKFER---PSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTF 319
Query: 2336 LDL--VPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
V ++L D + G + VD E++ L F+V A D G+ P++A V + +
Sbjct: 320 HQAPEVVRRLLRL-DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVK 378
Query: 2394 DINDNNPIFD-----QPSYQEA---VFEDVPVGTIILTVTATDADSG-NFALIEYSLGDG 2444
D+NDN P + ++Q+ + EDV T + V +D D G N A+ GD
Sbjct: 379 DMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDV 438
Query: 2445 ESKFAINPTTGD-------IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVI 2497
+ TG + + LD EK Y + +A D+ S+ NS++V
Sbjct: 439 PFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSST--NSLKV-- 494
Query: 2498 QVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEG-PGVEA- 2555
QV+DVND P F++ + EN G + + A+D D G N EL YSLE P +
Sbjct: 495 QVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL 554
Query: 2556 FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVR 2613
F + ++G + + L + E + L VVA D G P L GT +LV V+D NDN P F+
Sbjct: 555 FTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFML 614
Query: 2614 PPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLI 2673
+G + E +P S V V D D+G N V+ S + G+ F+I +G I
Sbjct: 615 --SGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-----FVIQNGTGTI 667
Query: 2674 QTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQ 2733
++ DRE Q+ Y+ L A D G P P + + + D +DN P P S ++
Sbjct: 668 LSSLSFDREQQSTYTFQLKAVDGGVP-PRSAYVGVTINVLDENDNAPYITAPSNTS--HK 724
Query: 2734 LLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHL-QPDGCLLVLRDLD 2792
LLT + G V V A D D G NA + Y IA GN F + G + + ++++
Sbjct: 725 LLT--PQTRLGETVSQVA-AEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE 781
Query: 2793 REREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDI 2839
R + +VK S PPR + + L + TL R +LE +
Sbjct: 782 RRHHGLHRLVVKVSDRGK--PPRYGTALVHLYVNETLAN-RTLLETL 825
Score = 226 bits (576), Expect = 3e-58
Identities = 194/664 (29%), Positives = 301/664 (45%), Gaps = 52/664 (7%)
Query: 120 IQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ--PPSQ- 176
I+V D+NDN P F + ++ IPENT +G+ I A+D D G G Y Q P +Q
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 177 FFAIDSA------RGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQ 230
F + A + + V+ LD E +Y LT+ D + P ++ A L + + D
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQD-GGSPPRASSALLRVTVLDTN 274
Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGN--TNSIFALDY 288
D P F Y + E+SP G +V + A D D+G I YT + LD
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDR 334
Query: 289 ISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 348
+G++T+ G +DRE+ + T++ + L DR + + + V D+NDNAP
Sbjct: 335 NTGLITVQGPVDRED-------LSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387
Query: 349 --------NSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHF-I 399
+ I+E A+ L +QV D+DE G N+ + G+
Sbjct: 388 EIRGIGLVTHQDGMANISEDVAEETAVAL-VQVSDRDE--GENAAVTCVVAGDVPFQLRQ 444
Query: 400 ISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRP 458
S T K ++ PLDYE V Y ++ A +S P +K+ +++ NDN P
Sbjct: 445 ASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAP 504
Query: 459 IFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP---DRFSLDKDTGLI 515
+F+Q + ++ EN G + + A+D D+G+ E+ Y +P F++ +TG I
Sbjct: 505 VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEI 564
Query: 516 MLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKDAYVGALREN 573
+ LD E + + L ++A D G + T V +NVLD NDN P F Y ++ EN
Sbjct: 565 QVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMEN 624
Query: 574 EPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQIS 633
P+++ + + D D N Q+ S+ + D + G G I S D EQ S
Sbjct: 625 MPALSPVGMVTVIDGDKGENAQVQLSVEQDNG-----DFVIQNGTGTILSSLSFDREQQS 679
Query: 634 NGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPA--YFVSVVENIMAGATVL 691
L A+D G PP ++ V VTI V DENDN P + P+ + G TV
Sbjct: 680 TYTFQL--KAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVS 737
Query: 692 FLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVRA 748
+ A D D +IYS+ G F+I + SG IT ++R + L+V+
Sbjct: 738 QVAAEDFDSG---VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794
Query: 749 VDGG 752
D G
Sbjct: 795 SDRG 798
Score = 213 bits (543), Expect = 2e-54
Identities = 190/636 (29%), Positives = 287/636 (45%), Gaps = 66/636 (10%)
Query: 2281 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL---- 2336
+ V D+NDNTP F IT I E G+ A D D G NG+ +Y L
Sbjct: 156 IEVQDINDNTPNFASPVITL---AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212
Query: 2337 --DLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVD 2394
+L + ++ ++I +D E + T++ D GSPPRA+ + + ++D
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD 272
Query: 2395 INDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG----ESKFAI 2450
NDN P F++PSY+ + E+ P+G ++ V A D+D G A IEY+ +
Sbjct: 273 TNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332
Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF- 2509
+ TG I V +DRE + LAKD +N + QVV+ V D+ND P
Sbjct: 333 DRNTGLITVQGPVDREDLSTLRFSVLAKDR----GTNPKSARAQVVVTVKDMNDNAPTIE 388
Query: 2510 -------SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDS 2562
+ ++ E+ T+V + +D+DEG N +T + G ++
Sbjct: 389 IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448
Query: 2563 G-------LVTTQRPLQSYEK---FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFV 2612
G + T PL YEK +++ +VA D G PPL T L V+V+DVNDN PVF
Sbjct: 449 GSDSKKKYFLQTTTPL-DYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFT 507
Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGL 2672
+ + T + E + E+ A+D D G N + YS + F I P +G
Sbjct: 508 Q--SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKG--LFTISPETGE 563
Query: 2673 IQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQY 2732
IQ LDRE + Y L +VA+D G P T L V + D +DN+P F+
Sbjct: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVL-VNVLDCNDNDPKFMLSGYN---- 618
Query: 2733 QLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQ-PDGCLLVLRDL 2791
+V E+ P + VG VT +D D+G NA V + N + F +Q G +L
Sbjct: 619 --FSVMENMPALSPVGMVT-VIDGDKGENAQVQLSVEQDNGD--FVIQNGTGTILSSLSF 673
Query: 2792 DREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEY 2851
DRE+++ ++F +KA PPR V + + D ND P T
Sbjct: 674 DREQQSTYTFQLKAVD--GGVPPRS-----------AYVGVTINVLDENDNAPYITAPSN 720
Query: 2852 TAG--VATDAKVGSELIQVLALDADIGNNSLVFYSI 2885
T+ + ++G + QV A D D G N+ + YSI
Sbjct: 721 TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI 756
Score = 213 bits (541), Expect = 3e-54
Identities = 208/744 (27%), Positives = 319/744 (42%), Gaps = 68/744 (9%)
Query: 1904 TTGIVTVNRPLDRERIPE-----------YKLTISVKDNPEN--PRIARRDYDLLLIFLS 1950
T I T +DRE + E + +S+ D +N PR+ ++
Sbjct: 105 TGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEV-----Q 159
Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG-- 2008
D NDN P F + EN+ G+ + LA D D V +Y+L
Sbjct: 160 DINDNTPNFASPVITLAIPENTNIGSLFPIP----LASDRDAGPNGVASYELQAGPEAQE 215
Query: 2009 LFDINSSTGVVTVRSGVII----DREAFSPPILELLLLAEDIGL--LNSTAHLLITILDD 2062
LF + + + +I+ DRE + +L + +D G S+A L +T+LD
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDS--YDLTIKVQDGGSPPRASSALLRVTVLDT 273
Query: 2063 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI-EAGAQDRFLIHLV 2121
NDN P F + L EN P G SV+QV A D D G N E+ Y +A R L+ L
Sbjct: 274 NDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLD 333
Query: 2122 --TGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF-LNPI 2178
TG+I V +DRE+ + R +V+A DRGT P S A V + + D+ND+ P + I
Sbjct: 334 RNTGLITV-QGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGI 392
Query: 2179 QTVS-------VLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAF 2231
V+ + E T +A + D D E V V D + +
Sbjct: 393 GLVTHQDGMANISEDVAEETAVALVQVSDRDEG---ENAAVTCVVAGDVPFQLRQASETG 449
Query: 2232 AVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTP 2291
+ + + +P++ E V Y + + +D+ + +S N+ L V V+DVNDN P
Sbjct: 450 SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNP----PLSSTNS-LKVQVVDVNDNAP 504
Query: 2292 QFKPFGITYYMERIL--EGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDS 2349
F T + + E PG + + A D D G N + Y+L +
Sbjct: 505 VF-----TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISP 559
Query: 2350 SAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQE 2409
G++ ++D E+ V A+D GSP V + ++D NDN+P F Y
Sbjct: 560 ETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNF 619
Query: 2410 AVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKD 2469
+V E++P + + VT D D G A ++ S+ F I TG I S DRE++
Sbjct: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQS 679
Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS--VYENEPAGTS 2527
Y A D G V R V V I VLD ND P + P ++ + G +
Sbjct: 680 TYTFQLKAVD--GGVPP--RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGET 735
Query: 2528 VITMMATDQDEGPNGELTYSLEGPG-VEAFHVDMDSGLVTTQRPLQ--SYEKFSLTVVAT 2584
V + A D D G N EL YS+ G F + SG +T ++ ++ + L V +
Sbjct: 736 VSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVS 795
Query: 2585 DGGEPPLWGTTMLLVEVIDVNDNR 2608
D G+PP +GT ++ + V + NR
Sbjct: 796 DRGKPPRYGTALVHLYVNETLANR 819
Score = 166 bits (421), Expect = 3e-40
Identities = 174/657 (26%), Positives = 264/657 (40%), Gaps = 54/657 (8%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDNDPLVFGVS------GEEASRFFAV------EPDTGVV 87
L I E+T +GS LA D D P GV+ G EA F + E +
Sbjct: 175 LAIPENTNIGSLFPIPLASDRDAGPN--GVASYELQAGPEAQELFGLQVAEDQEEKQPQL 232
Query: 88 WLRQPLDRETKSEFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIPEN 144
+ LDRE + + V D + + + V D NDNAP F Y + EN
Sbjct: 233 IVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSEN 292
Query: 145 TPVGTPIFIVNATDPDLGAGGSVLYSF-QPPS---QFFAIDSARGIVTVIRELDYETTQA 200
+P+G + V A D D GA + Y+F Q P + +D G++TV +D E
Sbjct: 293 SPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLST 352
Query: 201 YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP--------IFINLPYSTNIYEHSPPG 252
+ +V A D+ T P S A + + + D+ D P + + NI E
Sbjct: 353 LRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEE 411
Query: 253 TTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPL-YSHGFI 311
T V ++ D+D+G + + + L PL Y
Sbjct: 412 TAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKD 471
Query: 312 LTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFI 371
T++ ++ P + T + + V+D+NDNAP F S VA E + G +
Sbjct: 472 YTIEIVAVDSGNPPLSS--TNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG---EVIA 526
Query: 372 QVVDKDENLGLNSMFEVYLVGNNSHH--FIISPTSVQGKADIRIRVAIPLDYETVDRYDF 429
++ D + G N+ L + F ISP + + I+V LD E + Y+
Sbjct: 527 EITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE------IQVKTSLDREQRESYEL 580
Query: 430 DLF-ANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDND 488
+ A+ P G A V + +++ NDN P F YN S+ EN+ + V V D D
Sbjct: 581 KVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGD 640
Query: 489 AGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--R 546
G +V D F + TG I+ D E +T + A DGG +
Sbjct: 641 KGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG 700
Query: 547 VRINVLDVNDNVP--TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS 604
V INVLD NDN P T + L + ++ A D DS N ++ YSI +
Sbjct: 701 VTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGN 760
Query: 605 AFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
+G F I + G +++ + E+ +GL L V D G PP T V + V
Sbjct: 761 PYG-LFQIGSHSG----AITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
Score = 142 bits (357), Expect = 7e-33
Identities = 141/539 (26%), Positives = 226/539 (41%), Gaps = 73/539 (13%)
Query: 2413 EDVPVGTIILTVTATDA--DSGNFALIEYSLGDGESKFAINPTTGDIYVL-SSLDREKKD 2469
E+ P T+I ++ A D G+ Y L G ++ TGDI+ +S+DRE
Sbjct: 66 EEQPPNTLIGSLAADYGFPDVGHL----YKLEVGAPYLRVDGKTGDIFTTETSIDREG-- 119
Query: 2470 HYILTALAKDNPGD------------VASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 2517
L PGD + N ++ I+V D+ND P F+ P + +
Sbjct: 120 ---LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLA 176
Query: 2518 VYENEPAGTSVITMMATDQDEGPNGELTYSLE-GP-GVEAFHVDMDSGLVTTQRPL---- 2571
+ EN G+ +A+D+D GPNG +Y L+ GP E F + + Q L
Sbjct: 177 IPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMG 236
Query: 2572 ----QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIP 2627
+ ++ + LT+ DGG PP + +L V V+D NDN P F RP + E P
Sbjct: 237 NLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEA--ELSENSP 294
Query: 2628 LRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2687
+ +V +V A D D+G N + Y+F A +D +GLI +DRE +
Sbjct: 295 IGHSVIQVKANDSDQGANAEIEYTF-HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTL 353
Query: 2688 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQ--LLTVPEHSPRGT 2745
++A D G P + V ++D++DN P G +Q + + E T
Sbjct: 354 RFSVLAKDRGTN-PKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEET 412
Query: 2746 LVGNVTGAVDADEGPNAIVYYFIA-------------AGNEEKNFHLQPDGCLLVLRDLD 2792
V V D DEG NA V +A + +K + LQ L D +
Sbjct: 413 AVALVQ-VSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPL----DYE 467
Query: 2793 REREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYT 2852
+ ++ + S N PP + +L +V + D+ND P FT++
Sbjct: 468 KVKDYTIEIVAVDSGN----PPLSSTNSL-----------KVQVVDVNDNAPVFTQSVTE 512
Query: 2853 AGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMD 2911
+ K G + ++ A DAD G+N+ + YS+ + L S + G++ S+D
Sbjct: 513 VAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLD 571
>gi|27754771 protocadherin 1 isoform 1 precursor [Homo sapiens]
Length = 1060
Score = 265 bits (678), Expect = 4e-70
Identities = 215/701 (30%), Positives = 323/701 (46%), Gaps = 62/701 (8%)
Query: 1732 VNVNDINDNVPTFPRDYEGPFEVTEGQPGPRVWTFLAHDRDSGPNGQVEYSIMDGDPLGE 1791
+ V DINDN P F G LA DRD+GPNG Y + G E
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 1792 FVISPVEGVLRVRKDVE-----------LDRETIAFYNLTICARDRGMPPLSSTMLVGIR 1840
L+V +D E LDRE Y+LTI +D G PP +S+ L+ +
Sbjct: 216 LF------GLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVT 269
Query: 1841 VLDINDNDPVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARL--TFNITAGNRERA 1898
VLD NDN P +SENSP+ V V A+D+D G NA + TF+ R
Sbjct: 270 VLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRL 329
Query: 1899 FFINATTGIVTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHP- 1957
++ TG++TV P+DRE + + ++ KD NP+ AR +++ + D NDN P
Sbjct: 330 LRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQ---VVVTVKDMNDNAPT 386
Query: 1958 -------LFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLF 2010
L T A + E+ T + ++ D D+ A VT + G
Sbjct: 387 IEIRGIGLVTHQDGMANISEDVAEETAVALVQ----VSDRDEGENAAVTCVVAGDVPFQL 442
Query: 2011 DINSSTGVVTVRSGVI-----IDREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDN 2065
S TG + + + +D E +E++ + L+ST L + ++D NDN
Sbjct: 443 RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502
Query: 2066 RPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRIEA--GAQDRFLIHLVTG 2123
P F+ + V EN PG + ++TA+D DSG N ELVY +E A+ F I TG
Sbjct: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562
Query: 2124 VIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEFLNPIQTVSV 2183
I+V ++DRE++ESY L VVA DRG+ L GTA V + + D ND+ P+F+ SV
Sbjct: 563 EIQV-KTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSV 621
Query: 2184 LESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAFAVNINTGSVMVK 2243
+E+ + + +T ID D + + V +D+ D F + TG+++
Sbjct: 622 MENMPALSPVGMVTVIDGDKGENAQVQL--SVEQDNGD---------FVIQNGTGTILSS 670
Query: 2244 SPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTPQFKPFGITYYME 2303
+RE +TY L +D +P RS V +T+NVLD NDN P T +
Sbjct: 671 LSFDREQQSTYTFQLKAVDGG--VPPRSAYV---GVTINVLDENDNAPYITAPSNTSH-- 723
Query: 2304 RILEGATP-GTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDSSAGKVIANRTVDY 2362
++L T G T+ VAA D D G+N + Y++ P G Q+ S +G + + ++
Sbjct: 724 KLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQI-GSHSGAITLEKEIER 782
Query: 2363 EEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFD 2403
V+ SD G PPR V+L + + N + +
Sbjct: 783 RHHGLHRLVVKVSDRGKPPRYGTALVHLYVNETLANRTLLE 823
Score = 261 bits (667), Expect = 8e-69
Identities = 226/779 (29%), Positives = 347/779 (44%), Gaps = 72/779 (9%)
Query: 247 EHSPPGTTVRIITAIDQDKGRPR---------GIGYTIVSGNTNSIFALDYISGVLTLNG 297
E PP T + + A D G P G Y V G T IF + + G
Sbjct: 66 EEQPPNTLIGSLAA---DYGFPDVGHLYKLEVGAPYLRVDGKTGDIFTTETS---IDREG 119
Query: 298 LLDRENPLYSHGFILT--VKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSV 355
L + +N L IL V T+L + +P I V DINDN P F S ++
Sbjct: 120 LRECQNQLPGDPCILEFEVSITDLVQNGSPR----LLEGQIEVQDINDNTPNFASPVITL 175
Query: 356 AITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHFIISPTSVQGKADIRIRV 415
AI E +G P+ + D+D + +E+ F + Q + ++ V
Sbjct: 176 AIPENTNIGSLFPIPL-ASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIV 234
Query: 416 AIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVT 474
LD E D YD + + P A +++T+++ NDN P F +P Y L EN
Sbjct: 235 MGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSP 294
Query: 475 VGTSVLTVLATDNDAGTFGEVSYFFSDDPD----RFSLDKDTGLIMLIARLDYELIQRFT 530
+G SV+ V A D+D G E+ Y F P+ LD++TGLI + +D E +
Sbjct: 295 IGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLR 354
Query: 531 LTIIARDGGGEETTGR--VRINVLDVNDNVPTFQ--------KDAYVGALRENEPSVTQL 580
+++A+D G + R V + V D+NDN PT + + + E+ T +
Sbjct: 355 FSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAV 414
Query: 581 VRLRATDEDSPPNNQIT--------YSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQI 632
++ +D D N +T + + AS GS + + + PLDYE++
Sbjct: 415 ALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYF-----LQTTTPLDYEKV 469
Query: 633 SNGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLF 692
+ I ++A+D+GNPPL+ST + ++V D NDN P F++ V+ EN G +
Sbjct: 470 KDYTI--EIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAE 527
Query: 693 LNATDLDRSREYGQESIIYSLE----GSTQFRINARSGEITTTSLLDRETKSEYILIVRA 748
+ A+D D ++YSLE F I+ +GEI + LDRE + Y L V A
Sbjct: 528 ITASDADSG---SNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLDREQRESYELKVVA 584
Query: 749 VDGGVGHNQKTGIATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLG 808
D G Q G ATV + +LD NDN P + + Y +++E P S V V +D D G
Sbjct: 585 ADRGSPSLQ--GTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGDKG 642
Query: 809 ENGTLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPL 868
EN + S++ N + + + TG I ++ DRE + +L D G PP
Sbjct: 643 ENAQVQLSVEQDNGDFVIQNGTGTILSS-LSFDREQQSTYTFQL------KAVDGGVPPR 695
Query: 869 KATSSATVFVNLLDLNDNDPTFQNLPFVAEVL--EGIPAGVSIYQVVAIDLDEGLNGLVS 926
A T +N+LD NDN P + L G ++ QV A D D G+N +
Sbjct: 696 SAYVGVT--INVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELI 753
Query: 927 YRMPVGMPRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHV 985
Y + G P F I S SG + E++R ++L V SD G P + T+ + ++V
Sbjct: 754 YSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
Score = 256 bits (653), Expect = 3e-67
Identities = 211/682 (30%), Positives = 321/682 (47%), Gaps = 51/682 (7%)
Query: 1514 QVTILDINDNPPVIESPFGYNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYITEGNKD 1573
Q+ + DINDN P SP +++ EN G+ A+DRD G N V SY + G +
Sbjct: 155 QIEVQDINDNTPNFASPV-ITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEA 213
Query: 1574 MA-FRMDRISGEIATRP-----APPDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDE 1627
F + + +P DRER Y L V+D G+P +++ + VT++D
Sbjct: 214 QELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDT 273
Query: 1628 NDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLDEGPNGTVTYAI-VAGNIVNTF-RI 1685
NDNAP F++P YE L E + S+I ++A D D+G N + Y A +V R+
Sbjct: 274 NDNAPKFERPSYEAELSEN-SPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332
Query: 1686 DRHMGVITAAKELDYE-ISHGRYTLIVTATDQCPILSHRLTSTTTVLVNVNDINDNVPTF 1744
DR+ G+IT +D E +S R++++ P ++ V+V V D+NDN PT
Sbjct: 333 DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNP-----KSARAQVVVTVKDMNDNAPTI 387
Query: 1745 P-------RDYEGPFEVTEGQPGPRVWTFL-AHDRDSGPN--------GQVEYSIMDGDP 1788
+G ++E + DRD G N G V + +
Sbjct: 388 EIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE 447
Query: 1789 LGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRGMPPLSSTMLVGIRVLDINDND 1848
G S + ++ LD E + Y + I A D G PPLSST + ++V+D+NDN
Sbjct: 448 TG----SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNA 503
Query: 1849 PVLLNLPMNITISENSPVSSFVAHVLASDADSGCNARLTFNITAGNRERAFF-INATTGI 1907
PV + EN+ +A + ASDADSG NA L +++ + F I+ TG
Sbjct: 504 PVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE 563
Query: 1908 VTVNRPLDRERIPEYKLTISVKDNPENPRIARRDYDLLLIFLSDENDNHPLFTKSTYQAE 1967
+ V LDRE+ Y+L + D +P + + +L+ + D NDN P F S Y
Sbjct: 564 IQVKTSLDREQRESYELKVVAADR-GSPSL--QGTATVLVNVLDCNDNDPKFMLSGYNFS 620
Query: 1968 VMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSGLFDINSSTGVVTVRSGVII 2027
VMEN PA +P+ G + +D D+ A V + +G F I + TG T+ S +
Sbjct: 621 VMENMPALSPV----GMVTVIDGDKGENAQVQLS-VEQDNGDFVIQNGTG--TILSSLSF 673
Query: 2028 DREAFSPPILELLLLAEDIGLLNSTAHLLITILDDNDNRPTFSPATLTVH--LLENCPPG 2085
DRE S +L + + ++ + I +LD+NDN P + + T H L G
Sbjct: 674 DREQQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLG 733
Query: 2086 FSVLQVTATDEDSGLNGELVYRIEAG-AQDRFLIHLVTGVIRVGNATIDREEQESYRLTV 2144
+V QV A D DSG+N EL+Y I G F I +G I + I+R +RL V
Sbjct: 734 ETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITL-EKEIERRHHGLHRLVV 792
Query: 2145 VATDRGTVPLSGTAIVTILIDD 2166
+DRG P GTA+V + +++
Sbjct: 793 KVSDRGKPPRYGTALVHLYVNE 814
Score = 253 bits (646), Expect = 2e-66
Identities = 213/701 (30%), Positives = 322/701 (45%), Gaps = 52/701 (7%)
Query: 1196 VYVEDINDEAPVFTQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGK 1255
+ V+DIND P F + L + E IG+ + A+DRD+G G+ +Y + +G E +
Sbjct: 156 IEVQDINDNTPNFASPVIT-LAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQ 214
Query: 1256 F--------EIDESTGLIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNEL 1307
+ +E +I + LD E SY + + D P + +T+L+
Sbjct: 215 ELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTN 274
Query: 1308 DEAVQFSNASYEAAILENLALGTEIVRVQAYSIDN--LNQITYRFNAYTSTQAKALFKID 1365
D A +F SYEA + EN +G +++V+A D +I Y F+ + L ++D
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEV-VRRLLRLD 333
Query: 1366 AITGVITVQGLVDREKGDFYTLTVVADDGGPKVDST-VKVYITVLDENDNSPRFDFTS-- 1422
TG+ITVQG VDRE +V+A D G S +V +TV D NDN+P +
Sbjct: 334 RNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGIG 393
Query: 1423 -----DSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLASG---NIAGAFEIVTTND 1474
D +I ED VA V+ D D G N V +A + A E T +D
Sbjct: 394 LVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASE--TGSD 451
Query: 1475 SIGEVFV--ARPLDREELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFG 1532
S + F+ PLD E++ Y +++VA D G PP + L+V ++D+NDN PV
Sbjct: 452 SKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFTQSVT 511
Query: 1533 YNVSVNENVGGGTAVVQVRATDRDIGINSVLSYYIT-EGNKDMAFRMDRISGEIATRPAP 1591
V+ EN G + ++ A+D D G N+ L Y + E F + +GEI + +
Sbjct: 512 -EVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSL 570
Query: 1592 PDRERQSFYHLVATVEDEGTPTLSATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLN 1651
DRE++ Y L D G+P+L T V V ++D NDN P F Y + E L+
Sbjct: 571 -DREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALS 629
Query: 1652 -TSLITIQALDLDEGPNGTVTYAIVAGNIVNTFRIDRHMGVITAAKELDYEISHGRYTLI 1710
++T+ +D D+G N V ++ N F I G I ++ D E YT
Sbjct: 630 PVGMVTV--IDGDKGENAQVQLSVEQDN--GDFVIQNGTGTILSSLSFDRE-QQSTYTFQ 684
Query: 1711 VTATDQ-CPILSHRLTSTTTVLVNVNDINDNVP--TFPRDYEGPFEVTEGQPGPRVWTFL 1767
+ A D P S + V +NV D NDN P T P + + + G V
Sbjct: 685 LKAVDGGVPPRS----AYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVA 740
Query: 1768 AHDRDSGPNGQVEYSIMDGDPLGEFVISPVEGVLRVRKDVELDRETIAFYNLTICARDRG 1827
A D DSG N ++ YSI G+P G F I G + + K++E R + L + DRG
Sbjct: 741 AEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE--RRHHGLHRLVVKVSDRG 798
Query: 1828 MPPLSSTMLVGIRVLDINDNDPVL-------LNLPMNITIS 1861
PP T LV + V + N +L L+ P++I I+
Sbjct: 799 KPPRYGTALVHLYVNETLANRTLLETLLGHSLDTPLDIDIA 839
Score = 252 bits (644), Expect = 4e-66
Identities = 235/801 (29%), Positives = 345/801 (43%), Gaps = 80/801 (9%)
Query: 927 YRMPVGMPRMDFLINSSSGVVVTT-TELDRERIAEYQLRVVASDAGTPTKSSTSTLT--- 982
Y++ VG P + ++ +G + TT T +DRE + E Q ++ + S + L
Sbjct: 90 YKLEVGAPYLR--VDGKTGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNG 147
Query: 983 --------IHVLDVNDETPTFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFI 1034
I V D+ND TP F V +++ E+ +D D G N SY +
Sbjct: 148 SPRLLEGQIEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYEL 207
Query: 1035 TGGNVDGKFSVGYRDAVVRT-------VVG-LDRETTAAYMLILEAIDNGPVGKRHTGTA 1086
G + + G + A + V+G LDRE +Y L ++ D G + +A
Sbjct: 208 QAGP-EAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPR--ASSA 264
Query: 1087 TVFVTVLDVNDNRPIFLQSSYEASVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNH 1146
+ VTVLD NDN P F + SYEA + E+ P GHS++Q+KA D+D+G + Y
Sbjct: 265 LLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPE 324
Query: 1147 --GNNFRIHVSNGLL-MRGPRPLDRERNSSHVLIVEAYNHDLGPMRSSVRVIVYVEDIND 1203
R+ + GL+ ++GP +DRE S+ V A + P + +V+V V+D+ND
Sbjct: 325 VVRRLLRLDRNTGLITVQGP--VDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMND 382
Query: 1204 EAPVF-------TQQQYSRLGLRETAGIGTSVIVVQATDRDSGDGGLVNYRILSGAEGKF 1256
AP Q + E T+V +VQ +DRD G+ V + +
Sbjct: 383 NAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQL 442
Query: 1257 EIDESTG-------LIITVNYLDYETKTSYMMNVSATDQAPPFNQGFCSVYITLLNELDE 1309
TG + T LDYE Y + + A D P S+ + +++ D
Sbjct: 443 RQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDN 502
Query: 1310 AVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAKALFKIDAITG 1369
A F+ + E A EN G I + A D+ + ++ AK LF I TG
Sbjct: 503 APVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETG 562
Query: 1370 VITVQGLVDREKGDFYTLTVV-ADDGGPKVDSTVKVYITVLDENDNSPRFDFTSDSAVSI 1428
I V+ +DRE+ + Y L VV AD G P + T V + VLD NDN P+F S S+
Sbjct: 563 EIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKF-MLSGYNFSV 621
Query: 1429 PEDCPVGQRVATVKAWDPDAGSNGQVVFSLASGNIAGAFEIVTTNDSIGEVFVARPLDRE 1488
E+ P V V D D G N QV S+ N G F I + G + + DRE
Sbjct: 622 MENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN--GDFVI---QNGTGTILSSLSFDRE 676
Query: 1489 ELDHYILQVVASDRGTPPRKKDHILQVTILDINDNPPVIESPFGYNVS-VNENVGGGTAV 1547
+ Y Q+ A D G PPR + + +LD NDN P I +P + + G V
Sbjct: 677 QQSTYTFQLKAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETV 736
Query: 1548 VQVRATDRDIGINSVLSYYITEGNKDMAFRMDRISGEIATRPAPPDRERQSFYHLVATVE 1607
QV A D D G+N+ L Y I GN F++ SG I T +R + LV V
Sbjct: 737 SQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAI-TLEKEIERRHHGLHRLVVKVS 795
Query: 1608 DEGTPTL--SATTHVYVTIVDENDNAPMFQQPHYEVLLDEGPDTLNTSLITIQALDLD-- 1663
D G P +A H+YV N + + E LL DT LD+D
Sbjct: 796 DRGKPPRYGTALVHLYV-------NETLANRTLLETLLGHSLDT---------PLDIDIA 839
Query: 1664 -------EGPNGTVTYAIVAG 1677
G + + +VAG
Sbjct: 840 GDPEYERSKQRGNILFGVVAG 860
Score = 230 bits (587), Expect = 2e-59
Identities = 194/691 (28%), Positives = 305/691 (44%), Gaps = 35/691 (5%)
Query: 530 TLTIIARDGGGEETTGRVRINVLDVNDNVPTFQKDAYVGALRENEPSVTQLVRLRATDED 589
++T + ++G G++ + D+NDN P F A+ EN + A+D D
Sbjct: 139 SITDLVQNGSPRLLEGQIEVQ--DINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRD 196
Query: 590 SPPNNQITYSIVSASAFGSYFDISLYEGYGV----ISVSRPLDYEQISNGLIYLTVMAMD 645
+ PN +Y + + F + + E + V LD E+ + LT+ D
Sbjct: 197 AGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDS--YDLTIKVQD 254
Query: 646 AGNPPLNSTVPVTIEVFDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYG 705
G+PP S+ + + V D NDN P F +P+Y + EN G +V+ + A D D+
Sbjct: 255 GGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAE 314
Query: 706 QESIIYSLEGSTQ--FRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGIAT 763
E + + R++ +G IT +DRE S V A D G N K+ A
Sbjct: 315 IEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTLRFSVLAKDRGT--NPKSARAQ 372
Query: 764 VNITLLDINDNHPTWKDAPYYI--------NLVEMTPPDSDVTTVVAVDPDLGENGTLVY 815
V +T+ D+NDN PT + + N+ E ++ V V D D GEN +
Sbjct: 373 VVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTC 432
Query: 816 SIQPPNKFYSLN-STTGKIRTTHAMLDRENPDPHEAELMRKIVVSVTDCGRPPLKATSSA 874
+ F S TG L P +E I + D G PPL +T+S
Sbjct: 433 VVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSL 492
Query: 875 TVFVNLLDLNDNDPTFQNLPFVAEVLEGIPAGVSIYQVVAIDLDEGLNGLVSYRM-PVGM 933
V V +D+NDN P F E G I ++ A D D G N + Y + P
Sbjct: 493 KVQV--VDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPA 550
Query: 934 PRMDFLINSSSGVVVTTTELDRERIAEYQLRVVASDAGTPTKSSTSTLTIHVLDVNDETP 993
+ F I+ +G + T LDRE+ Y+L+VVA+D G+P+ T+T+ ++VLD ND P
Sbjct: 551 AKGLFTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDP 610
Query: 994 TFFPAVYNVSVSEDVPREFRVVWLNCTDNDVGLNAELSYFITGGNVDGKFSVGYRDAVVR 1053
F + YN SV E++P V + D D G NA++ + N G F + +
Sbjct: 611 KFMLSGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDN--GDFVIQNGTGTIL 668
Query: 1054 TVVGLDRETTAAYMLILEAIDNG-PVGKRHTGTATVFVTVLDVNDNRPIFL---QSSYEA 1109
+ + DRE + Y L+A+D G P + G V + VLD NDN P +S++
Sbjct: 669 SSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG---VTINVLDENDNAPYITAPSNTSHKL 725
Query: 1110 SVPEDIPEGHSILQLKATDADEGEFGRVWYRILHGNHGNNFRIHVSNGLLMRGPRPLDRE 1169
P+ G ++ Q+ A D D G + Y I GN F+I +G + + ++R
Sbjct: 726 LTPQ-TRLGETVSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITL-EKEIERR 783
Query: 1170 RNSSHVLIVEAYNHDLGPMRSSVRVIVYVED 1200
+ H L+V+ + P + V +YV +
Sbjct: 784 HHGLHRLVVKVSDRGKPPRYGTALVHLYVNE 814
Score = 228 bits (581), Expect = 8e-59
Identities = 211/707 (29%), Positives = 329/707 (46%), Gaps = 66/707 (9%)
Query: 2162 ILIDDINDSRPEFLNPIQTVSVLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTD 2221
I + DIND+ P F +P+ T+++ E+ G++ A D D P G+ + +
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPN------GVASYEL-- 207
Query: 2222 RLVPNQEDAFAVNI------NTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVP 2275
+ P ++ F + + ++V ++RE +Y++T+ V D S P R+ S
Sbjct: 208 QAGPEAQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGS--PPRASS-- 263
Query: 2276 NAKLTVNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTL 2335
A L V VLD NDN P+F+ Y + E + G ++I V A D D+G N + YT
Sbjct: 264 -ALLRVTVLDTNDNAPKFER---PSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTF 319
Query: 2336 LDL--VPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIV 2393
V ++L D + G + VD E++ L F+V A D G+ P++A V + +
Sbjct: 320 HQAPEVVRRLLRL-DRNTGLITVQGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVK 378
Query: 2394 DINDNNPIFD-----QPSYQEA---VFEDVPVGTIILTVTATDADSG-NFALIEYSLGDG 2444
D+NDN P + ++Q+ + EDV T + V +D D G N A+ GD
Sbjct: 379 DMNDNAPTIEIRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDV 438
Query: 2445 ESKFAINPTTGD-------IYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVI 2497
+ TG + + LD EK Y + +A D+ S+ NS++V
Sbjct: 439 PFQLRQASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSST--NSLKV-- 494
Query: 2498 QVLDVNDCRPQFSKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEG-PGVEA- 2555
QV+DVND P F++ + EN G + + A+D D G N EL YSLE P +
Sbjct: 495 QVVDVNDNAPVFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGL 554
Query: 2556 FHVDMDSGLVTTQRPL--QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVR 2613
F + ++G + + L + E + L VVA D G P L GT +LV V+D NDN P F+
Sbjct: 555 FTISPETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFML 614
Query: 2614 PPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLI 2673
+G + E +P S V V D D+G N V+ S + G+ F+I +G I
Sbjct: 615 --SGYNFSVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGD-----FVIQNGTGTI 667
Query: 2674 QTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQ 2733
++ DRE Q+ Y+ L A D G P P + + + D +DN P P S ++
Sbjct: 668 LSSLSFDREQQSTYTFQLKAVDGGVP-PRSAYVGVTINVLDENDNAPYITAPSNTS--HK 724
Query: 2734 LLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHL-QPDGCLLVLRDLD 2792
LLT + G V V A D D G NA + Y IA GN F + G + + ++++
Sbjct: 725 LLT--PQTRLGETVSQVA-AEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIE 781
Query: 2793 REREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDI 2839
R + +VK S PPR + + L + TL R +LE +
Sbjct: 782 RRHHGLHRLVVKVSDRGK--PPRYGTALVHLYVNETLAN-RTLLETL 825
Score = 226 bits (576), Expect = 3e-58
Identities = 194/664 (29%), Positives = 301/664 (45%), Gaps = 52/664 (7%)
Query: 120 IQVGDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ--PPSQ- 176
I+V D+NDN P F + ++ IPENT +G+ I A+D D G G Y Q P +Q
Sbjct: 156 IEVQDINDNTPNFASPVITLAIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQE 215
Query: 177 FFAIDSA------RGIVTVIRELDYETTQAYQLTVNATDQDKTRPLSTLANLAIIITDVQ 230
F + A + + V+ LD E +Y LT+ D + P ++ A L + + D
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQD-GGSPPRASSALLRVTVLDTN 274
Query: 231 DMDPIFINLPYSTNIYEHSPPGTTVRIITAIDQDKGRPRGIGYTIVSGN--TNSIFALDY 288
D P F Y + E+SP G +V + A D D+G I YT + LD
Sbjct: 275 DNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDR 334
Query: 289 ISGVLTLNGLLDRENPLYSHGFILTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEF 348
+G++T+ G +DRE+ + T++ + L DR + + + V D+NDNAP
Sbjct: 335 NTGLITVQGPVDRED-------LSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTI 387
Query: 349 --------NSSEYSVAITELAQVGFALPLFIQVVDKDENLGLNSMFEVYLVGNNSHHF-I 399
+ I+E A+ L +QV D+DE G N+ + G+
Sbjct: 388 EIRGIGLVTHQDGMANISEDVAEETAVAL-VQVSDRDE--GENAAVTCVVAGDVPFQLRQ 444
Query: 400 ISPTSVQGKADIRIRVAIPLDYETVDRYDFDLFANES-VPDHVGYAKVKITLINENDNRP 458
S T K ++ PLDYE V Y ++ A +S P +K+ +++ NDN P
Sbjct: 445 ASETGSDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAP 504
Query: 459 IFSQPLYNISLYENVTVGTSVLTVLATDNDAGTFGEVSYFFSDDP---DRFSLDKDTGLI 515
+F+Q + ++ EN G + + A+D D+G+ E+ Y +P F++ +TG I
Sbjct: 505 VFTQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEI 564
Query: 516 MLIARLDYELIQRFTLTIIARDGGGE--ETTGRVRINVLDVNDNVPTFQKDAYVGALREN 573
+ LD E + + L ++A D G + T V +NVLD NDN P F Y ++ EN
Sbjct: 565 QVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMEN 624
Query: 574 EPSVTQLVRLRATDEDSPPNNQITYSIVSASAFGSYFDISLYEGYGVISVSRPLDYEQIS 633
P+++ + + D D N Q+ S+ + D + G G I S D EQ S
Sbjct: 625 MPALSPVGMVTVIDGDKGENAQVQLSVEQDNG-----DFVIQNGTGTILSSLSFDREQQS 679
Query: 634 NGLIYLTVMAMDAGNPPLNSTVPVTIEVFDENDNPPTFSKPA--YFVSVVENIMAGATVL 691
L A+D G PP ++ V VTI V DENDN P + P+ + G TV
Sbjct: 680 TYTFQL--KAVDGGVPPRSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVS 737
Query: 692 FLNATDLDRSREYGQESIIYSLEGSTQ---FRINARSGEITTTSLLDRETKSEYILIVRA 748
+ A D D +IYS+ G F+I + SG IT ++R + L+V+
Sbjct: 738 QVAAEDFDSG---VNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKV 794
Query: 749 VDGG 752
D G
Sbjct: 795 SDRG 798
Score = 213 bits (543), Expect = 2e-54
Identities = 190/636 (29%), Positives = 287/636 (45%), Gaps = 66/636 (10%)
Query: 2281 VNVLDVNDNTPQFKPFGITYYMERILEGATPGTTLIAVAAVDPDKGLNGLVTYTLL---- 2336
+ V D+NDNTP F IT I E G+ A D D G NG+ +Y L
Sbjct: 156 IEVQDINDNTPNFASPVITL---AIPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPE 212
Query: 2337 --DLVPPGYVQLEDSSAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVD 2394
+L + ++ ++I +D E + T++ D GSPPRA+ + + ++D
Sbjct: 213 AQELFGLQVAEDQEEKQPQLIVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLD 272
Query: 2395 INDNNPIFDQPSYQEAVFEDVPVGTIILTVTATDADSGNFALIEYSLGDG----ESKFAI 2450
NDN P F++PSY+ + E+ P+G ++ V A D+D G A IEY+ +
Sbjct: 273 TNDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRL 332
Query: 2451 NPTTGDIYVLSSLDREKKDHYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQF- 2509
+ TG I V +DRE + LAKD +N + QVV+ V D+ND P
Sbjct: 333 DRNTGLITVQGPVDREDLSTLRFSVLAKDR----GTNPKSARAQVVVTVKDMNDNAPTIE 388
Query: 2510 -------SKPQFSTSVYENEPAGTSVITMMATDQDEGPNGELTYSLEGPGVEAFHVDMDS 2562
+ ++ E+ T+V + +D+DEG N +T + G ++
Sbjct: 389 IRGIGLVTHQDGMANISEDVAEETAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASET 448
Query: 2563 G-------LVTTQRPLQSYEK---FSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFV 2612
G + T PL YEK +++ +VA D G PPL T L V+V+DVNDN PVF
Sbjct: 449 GSDSKKKYFLQTTTPL-DYEKVKDYTIEIVAVDSGNPPLSSTNSLKVQVVDVNDNAPVFT 507
Query: 2613 RPPNGTILHIREEIPLRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGL 2672
+ + T + E + E+ A+D D G N + YS + F I P +G
Sbjct: 508 Q--SVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKG--LFTISPETGE 563
Query: 2673 IQTAQRLDRESQAVYSLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQY 2732
IQ LDRE + Y L +VA+D G P T L V + D +DN+P F+
Sbjct: 564 IQVKTSLDREQRESYELKVVAADRGSPSLQGTATVL-VNVLDCNDNDPKFMLSGYN---- 618
Query: 2733 QLLTVPEHSPRGTLVGNVTGAVDADEGPNAIVYYFIAAGNEEKNFHLQ-PDGCLLVLRDL 2791
+V E+ P + VG VT +D D+G NA V + N + F +Q G +L
Sbjct: 619 --FSVMENMPALSPVGMVT-VIDGDKGENAQVQLSVEQDNGD--FVIQNGTGTILSSLSF 673
Query: 2792 DREREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEY 2851
DRE+++ ++F +KA PPR V + + D ND P T
Sbjct: 674 DREQQSTYTFQLKAVD--GGVPPRS-----------AYVGVTINVLDENDNAPYITAPSN 720
Query: 2852 TAG--VATDAKVGSELIQVLALDADIGNNSLVFYSI 2885
T+ + ++G + QV A D D G N+ + YSI
Sbjct: 721 TSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSI 756
Score = 213 bits (541), Expect = 3e-54
Identities = 208/744 (27%), Positives = 319/744 (42%), Gaps = 68/744 (9%)
Query: 1904 TTGIVTVNRPLDRERIPE-----------YKLTISVKDNPEN--PRIARRDYDLLLIFLS 1950
T I T +DRE + E + +S+ D +N PR+ ++
Sbjct: 105 TGDIFTTETSIDREGLRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEV-----Q 159
Query: 1951 DENDNHPLFTKSTYQAEVMENSPAGTPLTVLNGPILALDADQDIYAVVTYQLLGAQSG-- 2008
D NDN P F + EN+ G+ + LA D D V +Y+L
Sbjct: 160 DINDNTPNFASPVITLAIPENTNIGSLFPIP----LASDRDAGPNGVASYELQAGPEAQE 215
Query: 2009 LFDINSSTGVVTVRSGVII----DREAFSPPILELLLLAEDIGL--LNSTAHLLITILDD 2062
LF + + + +I+ DRE + +L + +D G S+A L +T+LD
Sbjct: 216 LFGLQVAEDQEEKQPQLIVMGNLDRERWDS--YDLTIKVQDGGSPPRASSALLRVTVLDT 273
Query: 2063 NDNRPTFSPATLTVHLLENCPPGFSVLQVTATDEDSGLNGELVYRI-EAGAQDRFLIHLV 2121
NDN P F + L EN P G SV+QV A D D G N E+ Y +A R L+ L
Sbjct: 274 NDNAPKFERPSYEAELSENSPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLD 333
Query: 2122 --TGVIRVGNATIDREEQESYRLTVVATDRGTVPLSGTAIVTILIDDINDSRPEF-LNPI 2178
TG+I V +DRE+ + R +V+A DRGT P S A V + + D+ND+ P + I
Sbjct: 334 RNTGLITV-QGPVDREDLSTLRFSVLAKDRGTNPKSARAQVVVTVKDMNDNAPTIEIRGI 392
Query: 2179 QTVS-------VLESAEPGTVIANITAIDHDLNPKLEYHIVGIVAKDDTDRLVPNQEDAF 2231
V+ + E T +A + D D E V V D + +
Sbjct: 393 GLVTHQDGMANISEDVAEETAVALVQVSDRDEG---ENAAVTCVVAGDVPFQLRQASETG 449
Query: 2232 AVNINTGSVMVKSPMNRELVATYEVTLSVIDNASDLPERSVSVPNAKLTVNVLDVNDNTP 2291
+ + + +P++ E V Y + + +D+ + +S N+ L V V+DVNDN P
Sbjct: 450 SDSKKKYFLQTTTPLDYEKVKDYTIEIVAVDSGNP----PLSSTNS-LKVQVVDVNDNAP 504
Query: 2292 QFKPFGITYYMERIL--EGATPGTTLIAVAAVDPDKGLNGLVTYTLLDLVPPGYVQLEDS 2349
F T + + E PG + + A D D G N + Y+L +
Sbjct: 505 VF-----TQSVTEVAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISP 559
Query: 2350 SAGKVIANRTVDYEEVHWLNFTVRASDNGSPPRAAEIPVYLEIVDINDNNPIFDQPSYQE 2409
G++ ++D E+ V A+D GSP V + ++D NDN+P F Y
Sbjct: 560 ETGEIQVKTSLDREQRESYELKVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNF 619
Query: 2410 AVFEDVPVGTIILTVTATDADSGNFALIEYSLGDGESKFAINPTTGDIYVLSSLDREKKD 2469
+V E++P + + VT D D G A ++ S+ F I TG I S DRE++
Sbjct: 620 SVMENMPALSPVGMVTVIDGDKGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQS 679
Query: 2470 HYILTALAKDNPGDVASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS--VYENEPAGTS 2527
Y A D G V R V V I VLD ND P + P ++ + G +
Sbjct: 680 TYTFQLKAVD--GGVPP--RSAYVGVTINVLDENDNAPYITAPSNTSHKLLTPQTRLGET 735
Query: 2528 VITMMATDQDEGPNGELTYSLEGPG-VEAFHVDMDSGLVTTQRPLQ--SYEKFSLTVVAT 2584
V + A D D G N EL YS+ G F + SG +T ++ ++ + L V +
Sbjct: 736 VSQVAAEDFDSGVNAELIYSIAGGNPYGLFQIGSHSGAITLEKEIERRHHGLHRLVVKVS 795
Query: 2585 DGGEPPLWGTTMLLVEVIDVNDNR 2608
D G+PP +GT ++ + V + NR
Sbjct: 796 DRGKPPRYGTALVHLYVNETLANR 819
Score = 166 bits (421), Expect = 3e-40
Identities = 174/657 (26%), Positives = 264/657 (40%), Gaps = 54/657 (8%)
Query: 40 LLISEDTPVGSSVTQLLAQDMDNDPLVFGVS------GEEASRFFAV------EPDTGVV 87
L I E+T +GS LA D D P GV+ G EA F + E +
Sbjct: 175 LAIPENTNIGSLFPIPLASDRDAGPN--GVASYELQAGPEAQELFGLQVAEDQEEKQPQL 232
Query: 88 WLRQPLDRETKSEFTVEFSVSDHQG---VITRKVNIQVGDVNDNAPTFHNQPYSVRIPEN 144
+ LDRE + + V D + + + V D NDNAP F Y + EN
Sbjct: 233 IVMGNLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEAELSEN 292
Query: 145 TPVGTPIFIVNATDPDLGAGGSVLYSF-QPPS---QFFAIDSARGIVTVIRELDYETTQA 200
+P+G + V A D D GA + Y+F Q P + +D G++TV +D E
Sbjct: 293 SPIGHSVIQVKANDSDQGANAEIEYTFHQAPEVVRRLLRLDRNTGLITVQGPVDREDLST 352
Query: 201 YQLTVNATDQDKTRPLSTLANLAIIITDVQDMDP--------IFINLPYSTNIYEHSPPG 252
+ +V A D+ T P S A + + + D+ D P + + NI E
Sbjct: 353 LRFSVLAKDRG-TNPKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEE 411
Query: 253 TTVRIITAIDQDKGRPRGIGYTIVSGNTNSIFALDYISGVLTLNGLLDRENPL-YSHGFI 311
T V ++ D+D+G + + + L PL Y
Sbjct: 412 TAVALVQVSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPLDYEKVKD 471
Query: 312 LTVKGTELNDDRTPSDATVTTTFNILVIDINDNAPEFNSSEYSVAITELAQVGFALPLFI 371
T++ ++ P + T + + V+D+NDNAP F S VA E + G +
Sbjct: 472 YTIEIVAVDSGNPPLSS--TNSLKVQVVDVNDNAPVFTQSVTEVAFPENNKPG---EVIA 526
Query: 372 QVVDKDENLGLNSMFEVYLVGNNSHH--FIISPTSVQGKADIRIRVAIPLDYETVDRYDF 429
++ D + G N+ L + F ISP + + I+V LD E + Y+
Sbjct: 527 EITASDADSGSNAELVYSLEPEPAAKGLFTISPETGE------IQVKTSLDREQRESYEL 580
Query: 430 DLF-ANESVPDHVGYAKVKITLINENDNRPIFSQPLYNISLYENVTVGTSVLTVLATDND 488
+ A+ P G A V + +++ NDN P F YN S+ EN+ + V V D D
Sbjct: 581 KVVAADRGSPSLQGTATVLVNVLDCNDNDPKFMLSGYNFSVMENMPALSPVGMVTVIDGD 640
Query: 489 AGTFGEVSYFFSDDPDRFSLDKDTGLIMLIARLDYELIQRFTLTIIARDGGGEETTG--R 546
G +V D F + TG I+ D E +T + A DGG +
Sbjct: 641 KGENAQVQLSVEQDNGDFVIQNGTGTILSSLSFDREQQSTYTFQLKAVDGGVPPRSAYVG 700
Query: 547 VRINVLDVNDNVP--TFQKDAYVGALRENEPSVTQLVRLRATDEDSPPNNQITYSIVSAS 604
V INVLD NDN P T + L + ++ A D DS N ++ YSI +
Sbjct: 701 VTINVLDENDNAPYITAPSNTSHKLLTPQTRLGETVSQVAAEDFDSGVNAELIYSIAGGN 760
Query: 605 AFGSYFDISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV 661
+G F I + G +++ + E+ +GL L V D G PP T V + V
Sbjct: 761 PYG-LFQIGSHSG----AITLEKEIERRHHGLHRLVVKVSDRGKPPRYGTALVHLYV 812
Score = 142 bits (357), Expect = 7e-33
Identities = 141/539 (26%), Positives = 226/539 (41%), Gaps = 73/539 (13%)
Query: 2413 EDVPVGTIILTVTATDA--DSGNFALIEYSLGDGESKFAINPTTGDIYVL-SSLDREKKD 2469
E+ P T+I ++ A D G+ Y L G ++ TGDI+ +S+DRE
Sbjct: 66 EEQPPNTLIGSLAADYGFPDVGHL----YKLEVGAPYLRVDGKTGDIFTTETSIDREG-- 119
Query: 2470 HYILTALAKDNPGD------------VASNRRENSVQVVIQVLDVNDCRPQFSKPQFSTS 2517
L PGD + N ++ I+V D+ND P F+ P + +
Sbjct: 120 ---LRECQNQLPGDPCILEFEVSITDLVQNGSPRLLEGQIEVQDINDNTPNFASPVITLA 176
Query: 2518 VYENEPAGTSVITMMATDQDEGPNGELTYSLE-GP-GVEAFHVDMDSGLVTTQRPL---- 2571
+ EN G+ +A+D+D GPNG +Y L+ GP E F + + Q L
Sbjct: 177 IPENTNIGSLFPIPLASDRDAGPNGVASYELQAGPEAQELFGLQVAEDQEEKQPQLIVMG 236
Query: 2572 ----QSYEKFSLTVVATDGGEPPLWGTTMLLVEVIDVNDNRPVFVRPPNGTILHIREEIP 2627
+ ++ + LT+ DGG PP + +L V V+D NDN P F RP + E P
Sbjct: 237 NLDRERWDSYDLTIKVQDGGSPPRASSALLRVTVLDTNDNAPKFERPSYEA--ELSENSP 294
Query: 2628 LRSNVYEVYATDKDEGLNGAVRYSFLKTAGNRDWEFFIIDPISGLIQTAQRLDRESQAVY 2687
+ +V +V A D D+G N + Y+F A +D +GLI +DRE +
Sbjct: 295 IGHSVIQVKANDSDQGANAEIEYTF-HQAPEVVRRLLRLDRNTGLITVQGPVDREDLSTL 353
Query: 2688 SLILVASDLGQPVPYETMQPLQVALEDIDDNEPLFVRPPKGSPQYQ--LLTVPEHSPRGT 2745
++A D G P + V ++D++DN P G +Q + + E T
Sbjct: 354 RFSVLAKDRGTN-PKSARAQVVVTVKDMNDNAPTIEIRGIGLVTHQDGMANISEDVAEET 412
Query: 2746 LVGNVTGAVDADEGPNAIVYYFIA-------------AGNEEKNFHLQPDGCLLVLRDLD 2792
V V D DEG NA V +A + +K + LQ L D +
Sbjct: 413 AVALVQ-VSDRDEGENAAVTCVVAGDVPFQLRQASETGSDSKKKYFLQTTTPL----DYE 467
Query: 2793 REREAIFSFIVKASSNRSWTPPRGPSPTLDLVADLTLQEVRVVLEDINDQPPRFTKAEYT 2852
+ ++ + S N PP + +L +V + D+ND P FT++
Sbjct: 468 KVKDYTIEIVAVDSGN----PPLSSTNSL-----------KVQVVDVNDNAPVFTQSVTE 512
Query: 2853 AGVATDAKVGSELIQVLALDADIGNNSLVFYSILAIHYFRALANDSEDVGQVFTMGSMD 2911
+ K G + ++ A DAD G+N+ + YS+ + L S + G++ S+D
Sbjct: 513 VAFPENNKPGEVIAEITASDADSGSNAELVYSLEPEPAAKGLFTISPETGEIQVKTSLD 571
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.136 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 124,664,309
Number of Sequences: 37866
Number of extensions: 5790916
Number of successful extensions: 49687
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 11426
Number of HSP's gapped (non-prelim): 3168
length of query: 3354
length of database: 18,247,518
effective HSP length: 121
effective length of query: 3233
effective length of database: 13,665,732
effective search space: 44181311556
effective search space used: 44181311556
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.