Search of human proteins with 189339233

Search of human proteins with 189339233

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189339233 cytochrome P450, family 2, subfamily A,
polypeptide 6 [Homo sapiens]
         (494 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   991   0.0  
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   936   0.0  
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   935   0.0  
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   808   0.0  
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   527   e-150
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   520   e-147
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   510   e-144
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   496   e-140
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   493   e-139
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   491   e-139
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   474   e-134
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   470   e-132
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   434   e-122
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   384   e-106
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   310   1e-84
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   309   3e-84
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   308   1e-83
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   295   8e-80
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   265   9e-71
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   247   2e-65
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   215   6e-56
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...   211   1e-54
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  192   4e-49
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   156   4e-38
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   127   2e-29
gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...   124   2e-28
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   119   6e-27
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   115   9e-26
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   115   9e-26
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   112   1e-24

>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  991 bits (2561), Expect = 0.0
 Identities = 494/494 (100%), Positives = 494/494 (100%)

Query: 1   MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK
Sbjct: 1   MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN 120
           ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN 120

Query: 121 GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSN 180
           GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSN 180

Query: 181 VISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL 240
           VISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL
Sbjct: 181 VISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL 240

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI 300
           LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI 300

Query: 301 GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ 360
           GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ
Sbjct: 301 GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ 360

Query: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEK 420
           RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEK
Sbjct: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEK 420

Query: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGF 480
           GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGF
Sbjct: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGF 480

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  936 bits (2419), Expect = 0.0
 Identities = 462/494 (93%), Positives = 477/494 (96%)

Query: 1   MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           MLASG+LLV LL CLTVMVLMSVW+QRKS+GKLPPGPTPLPFIGNYLQLNTEQMYNSLMK
Sbjct: 1   MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN 120
           ISERYGPVFTIHLGPRRVVVLCGHDAV+EALVDQAEEFSGRGEQATFDW+FKGYGV FSN
Sbjct: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120

Query: 121 GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSN 180
           GERAKQLRRFSIATLR FGVGKRGIEERIQEEAGFLIDALRGT GANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN 180

Query: 181 VISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL 240
           VISSIVFGDRFDY+DKEFLSLLRMMLG FQFT+TSTGQLYEMFSSVMKHLPGPQQQAF+ 
Sbjct: 181 VISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKE 240

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI 300
           LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLF 
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFF 300

Query: 301 GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ 360
            GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPY EAVIHEIQ
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQ 360

Query: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEK 420
           RFGD++PM LA RV KDTKFRDFFLPKGTEV+PMLGSVLRDP FFSNP+DFNPQHFL++K
Sbjct: 361 RFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKK 420

Query: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGF 480
           GQFKKSDAFVPFSIGKR CFGEGLARMELFLFFTT+MQNFR KS QSPKDIDVSPKHVGF
Sbjct: 421 GQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGF 480

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  935 bits (2416), Expect = 0.0
 Identities = 463/494 (93%), Positives = 480/494 (97%)

Query: 1   MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           MLASG+LLVALL CLTVMVLMSVWQQRKS+GKLPPGPTPLPFIGNYLQLNTE + +S+MK
Sbjct: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN 120
            SE YGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGV FSN
Sbjct: 61  FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120

Query: 121 GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSN 180
           GERAKQL RF+IATLRDFGVGKRGIEERIQEE+GFLI+A+R T GANIDPTFFLSRTVSN
Sbjct: 121 GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 180

Query: 181 VISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL 240
           VISSIVFGDRFDY+DKEFLSLL MMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF+L
Sbjct: 181 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 240

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI 300
           LQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQEEEKNPNTEFYLKNL+M+TLNLFI
Sbjct: 241 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 300

Query: 301 GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ 360
            GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR KMPYMEAVIHEIQ
Sbjct: 301 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 360

Query: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEK 420
           RFGDVIPMSLARRVKKDTKFRDFFLPKGTEV+PMLGSVLRDPSFFSNPQDFNPQHFL++K
Sbjct: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 420

Query: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGF 480
           GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHV F
Sbjct: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 480

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 481 ATIPRNYTMSFLPR 494


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  808 bits (2086), Expect = 0.0
 Identities = 412/494 (83%), Positives = 431/494 (87%), Gaps = 51/494 (10%)

Query: 1   MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           MLASG+LLVALL CLTVMVLMSVWQQRKS+GKLPPGPTPLPFIGNYLQLNTE + +S+MK
Sbjct: 1   MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN 120
           +S+                                                   GV FSN
Sbjct: 61  VSQ---------------------------------------------------GVAFSN 69

Query: 121 GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSN 180
           GERAKQL RF+IATLRDFGVGKRGIEERIQEE+GFLI+A+R T GANIDPTFFLSRTVSN
Sbjct: 70  GERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSN 129

Query: 181 VISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL 240
           VISSIVFGDRFDY+DKEFLSLL MMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF+L
Sbjct: 130 VISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKL 189

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFI 300
           LQGLEDFIAKKVEHNQRTLDPNSP+DFIDSFLI MQEEEKNPNTEFYLKNL+M+TLNLFI
Sbjct: 190 LQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFI 249

Query: 301 GGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQ 360
            GTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR KMPYMEAVIHEIQ
Sbjct: 250 AGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQ 309

Query: 361 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEK 420
           RFGDVIPMSLARRVKKDTKFRDFFLPKGTEV+PMLGSVLRDPSFFSNPQDFNPQHFL++K
Sbjct: 310 RFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDK 369

Query: 421 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGF 480
           GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHV F
Sbjct: 370 GQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVF 429

Query: 481 ATIPRNYTMSFLPR 494
           ATIPRNYTMSFLPR
Sbjct: 430 ATIPRNYTMSFLPR 443


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  527 bits (1358), Expect = e-150
 Identities = 250/487 (51%), Positives = 348/487 (71%)

Query: 8   LVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGP 67
           ++  L  LT ++L+ V +   +  +LPPGP PLP +GN LQ++   +  S ++  E+YG 
Sbjct: 5   VLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGD 64

Query: 68  VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQL 127
           VFT+HLGPR VV+LCG +A+REALVD+AE FSGRG+ A  D  F+GYGV+F+NG R K L
Sbjct: 65  VFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVL 124

Query: 128 RRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVF 187
           RRFS+ T+RDFG+GKR +EERIQEEA  LI+ LR + GA +DPTF      +N+I SIVF
Sbjct: 125 RRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVF 184

Query: 188 GDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDF 247
           G RF Y+D+EFL +L +    F   S+  GQL+E+FS  +K+ PG  +Q ++ LQ +  +
Sbjct: 185 GKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAY 244

Query: 248 IAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVS 307
           I   VE ++ TLDP++P+D ID++L+ M++E+ N ++EF  +NL + TL+LF  GTET S
Sbjct: 245 IGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTS 304

Query: 308 TTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIP 367
           TTLRYGFLL++K+P V  +V+ EI++VIG +R P+  DRAKMPY EAVI+EIQRF D++P
Sbjct: 305 TTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLP 364

Query: 368 MSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSD 427
           M +   V + T FR + +PK TEV+ +L + L DP +F  P  FNP HFL+  G  KK++
Sbjct: 365 MGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTE 424

Query: 428 AFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNY 487
           AF+PFS+GKR C GEG+AR ELFLFFTT++QNF + S  +P+DID++P+  G   IP  Y
Sbjct: 425 AFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTY 484

Query: 488 TMSFLPR 494
            + FLPR
Sbjct: 485 QIRFLPR 491


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  520 bits (1339), Expect = e-147
 Identities = 256/485 (52%), Positives = 344/485 (70%)

Query: 10  ALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVF 69
           A+L+ L  +V + +    + KGKLPPGP PL  +GN L L ++ M  SL K+S+ YG ++
Sbjct: 7   AILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMY 66

Query: 70  TIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRR 129
           T+HLGPRRVVVL G+ AV+EALVDQ EEFSGRG+   F    KG G+ FS+G+R K LR+
Sbjct: 67  TVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQ 126

Query: 130 FSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGD 189
           FSI  LR+FG+GKR IEERI EE  FL+  LR T G   DPTF LSR+VSN+I S++FG 
Sbjct: 127 FSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGS 186

Query: 190 RFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIA 249
           RFDY D+  L+++R++   FQ  S+  G+LY++F S++  +PGP Q+ FQ  + L D IA
Sbjct: 187 RFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIA 246

Query: 250 KKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTT 309
             V  +Q +LDP SPRDFI  FL +M EE+++P + F++  L+MTT NL  GGT+TVSTT
Sbjct: 247 HSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTT 306

Query: 310 LRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMS 369
           L + FL LMK+P+V+A+V EEID V+G+ R P  +DRA MPY +AVIHE+QRF D+IPM+
Sbjct: 307 LHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMN 366

Query: 370 LARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAF 429
           L  RV +DT FR F +PKGT+V  +L +V  DPS F  PQ+FNP+HFL+    FKKS AF
Sbjct: 367 LPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAF 426

Query: 430 VPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTM 489
           +PFS G+R C GE LARMELFL+ T ++Q+F L+   +P+DID++P   G   +PR + +
Sbjct: 427 MPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQL 486

Query: 490 SFLPR 494
              PR
Sbjct: 487 CLRPR 491


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  510 bits (1313), Expect = e-144
 Identities = 250/485 (51%), Positives = 345/485 (71%)

Query: 9   VALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68
           V L++CL+ ++L+S+W+Q   +GKLPPGPTPLP IGN LQ++ + +  SL  +S+ YGPV
Sbjct: 5   VVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLR 128
           FT++ G  R+VVL G++ V+EAL+D  EEFSGRG     +   +G+G+VFSNG+R K++R
Sbjct: 65  FTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIR 124

Query: 129 RFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFG 188
           RFS+ TLR+FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI SI+F 
Sbjct: 125 RFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQ 184

Query: 189 DRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFI 248
            RFDYKD++FL+L+  +    +  ST   Q+   F +++ + PG   +  + L  +E  I
Sbjct: 185 KRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDI 244

Query: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVST 308
            +KV+ +Q ++D N+PRDFID FLI+M++E++N  +EF ++NLV+T  +L   GTET ST
Sbjct: 245 LEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTST 304

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM 368
           TLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR  MPY +AV+HE+QR+ D+IP 
Sbjct: 305 TLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPT 364

Query: 369 SLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDA 428
           SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P+HFL+E G FKKS+ 
Sbjct: 365 SLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNY 424

Query: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF T ++QNF LKS   PKD+D +P   GFA++P  Y 
Sbjct: 425 FMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQ 484

Query: 489 MSFLP 493
           + F+P
Sbjct: 485 LCFIP 489


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  496 bits (1278), Expect = e-140
 Identities = 240/485 (49%), Positives = 340/485 (70%)

Query: 9   VALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68
           VAL++CL+ + L+S+W+Q   +G+LP GPTPLP IGN LQL+ + M  SL   S+ YGPV
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLR 128
           FT++ G + +VVL G++AV+EAL+D  EEFSGRG     + V KG G++FSNG+R K++R
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124

Query: 129 RFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFG 188
           RF + TLR+FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI S++F 
Sbjct: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184

Query: 189 DRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFI 248
           DRFDYKD+ FL+L+       +  S+   Q+   F +++ +LPG   +  +    ++ ++
Sbjct: 185 DRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYV 244

Query: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVST 308
            ++++ +Q +LD NS RDFID FLI+M++E+ N  +EF +++L+ T  ++F  GTET ST
Sbjct: 245 LERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTST 304

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM 368
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 305 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 364

Query: 369 SLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDA 428
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFL++ G FKKSD 
Sbjct: 365 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 424

Query: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 425 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 484

Query: 489 MSFLP 493
           + F+P
Sbjct: 485 LCFIP 489


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  493 bits (1269), Expect = e-139
 Identities = 241/486 (49%), Positives = 344/486 (70%)

Query: 8   LVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGP 67
           LV L++CL+ ++L+S+W+Q   +GKLPPGPTPLP IGN LQ+  + +  SL  +S+ YGP
Sbjct: 4   LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63

Query: 68  VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQL 127
           VFT++ G + +VVL G++AV+EAL+D  EEFSGRG     +   +G+G+VFSNG++ K++
Sbjct: 64  VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123

Query: 128 RRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVF 187
           RRFS+ TLR+FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI SI+F
Sbjct: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183

Query: 188 GDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDF 247
             RFDYKD++FL+L+  +    +  S+   Q+   FS ++ + PG   +  + +  ++ +
Sbjct: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSY 243

Query: 248 IAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVS 307
           I +KV+ +Q ++D N+P+DFID FL++M++E+ N  +EF +++L  T ++LF  GTET S
Sbjct: 244 ILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTS 303

Query: 308 TTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIP 367
           TTLRY  LLL+KHPEV AKV EEI+RVIG+NR P  +DR+ MPY +AV+HE+QR+ D++P
Sbjct: 304 TTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLP 363

Query: 368 MSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSD 427
            SL   V  D KFR++ +PKGT +   L SVL D   F NP+ F+P HFL+E G FKKS 
Sbjct: 364 TSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSK 423

Query: 428 AFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNY 487
            F+PFS GKR C GE LA MELFLF T+++QNF LKS   PK++D +P   GFA++P  Y
Sbjct: 424 YFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFY 483

Query: 488 TMSFLP 493
            + F+P
Sbjct: 484 QLCFIP 489


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  491 bits (1263), Expect = e-139
 Identities = 240/485 (49%), Positives = 333/485 (68%)

Query: 9   VALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68
           V L++CL+ M+L S+W+Q   + KLPPGPTPLP IGN LQ++ + +  S    S+ YGPV
Sbjct: 5   VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLR 128
           FT++ G   +VV  G++AV+EAL+D  EEFSGRG       + KG G++ SNG+R K++R
Sbjct: 65  FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124

Query: 129 RFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFG 188
           RFS+ TLR+FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI S+VF 
Sbjct: 125 RFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQ 184

Query: 189 DRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFI 248
            RFDYKD+ FL+L++     F+  ++   Q+   F  ++   PG   +  + +     +I
Sbjct: 185 KRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYI 244

Query: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVST 308
            +KV+ +Q +LD N+PRDFID FLI+M++E+ N  +EF ++NLV T  +LF+ GTET ST
Sbjct: 245 REKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTST 304

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM 368
           TLRYG LLL+KHPEV AKV EEID VIG++R P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 305 TLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPT 364

Query: 369 SLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDA 428
            +   V  DTKFR++ +PKGT +  +L SVL D   F NP  F+P HFL++ G FKKSD 
Sbjct: 365 GVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDY 424

Query: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS    K+++ +    G  ++P +Y 
Sbjct: 425 FMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQ 484

Query: 489 MSFLP 493
           + F+P
Sbjct: 485 ICFIP 489


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  474 bits (1221), Expect = e-134
 Identities = 232/486 (47%), Positives = 328/486 (67%), Gaps = 1/486 (0%)

Query: 9   VALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68
           VALLV    ++L+S+W+Q  S   LPPGP PLP IGN  QL  + +  S  ++++R+GPV
Sbjct: 8   VALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPV 67

Query: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLR 128
           FT+++G +R+VV+ G+ AV+EAL+D  +EFSGRG+   F    +  G++F+NG   K +R
Sbjct: 68  FTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFH-AHRDRGIIFNNGPTWKDIR 126

Query: 129 RFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFG 188
           RFS+ TLR++G+GK+G E RIQ EA FL++ALR T G   DPTF +     NVI+ I+F 
Sbjct: 127 RFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFR 186

Query: 189 DRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFI 248
             FDY D++FL L+ +    F   ST   QLY  F S + +LPG  ++  + +  +++++
Sbjct: 187 KHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYV 246

Query: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVST 308
           +++V+ + ++LDPN PRD  D  L+ M++E+ +    + +  + +T  +LF  GTET ST
Sbjct: 247 SERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTST 306

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM 368
           TLRYG L+LMK+PE+E K+HEEIDRVIG +R P  +DR +MPYM+AV+HEIQRF  ++P 
Sbjct: 307 TLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPS 366

Query: 369 SLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDA 428
           +L     +DT FR + +PKGT V P L SVL D   F +P+ F P+HFLNE G+FK SD 
Sbjct: 367 NLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDY 426

Query: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYT 488
           F PFS GKR C GEGLARMELFL    ++Q+F LK    PKDID+SP H+GF  IP  Y 
Sbjct: 427 FKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYK 486

Query: 489 MSFLPR 494
           +  +PR
Sbjct: 487 LCVIPR 492


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  470 bits (1209), Expect = e-132
 Identities = 235/487 (48%), Positives = 333/487 (68%), Gaps = 3/487 (0%)

Query: 10  ALLVCLTVMVLMSV-WQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68
           ALL+ L +++L+++     +++G LPPGPTPLP +GN LQL    +Y+ LM++S++YGPV
Sbjct: 8   ALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPV 67

Query: 69  FTIHLGP-RRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQL 127
           FTI+LGP R VVVL G +AVREAL  QAEEFSGRG  A  +  F G+GV FSNGER +QL
Sbjct: 68  FTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQL 127

Query: 128 RRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVF 187
           R+F++  LRD G+GKR  EE IQ EA  L++  +GT G   DP+  L++  SNV+ S++F
Sbjct: 128 RKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLF 187

Query: 188 GDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDF 247
           G RF Y+DKEF +++R   G     S+  GQ YEMFS  ++ LPGP +Q    +  L  F
Sbjct: 188 GLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAF 247

Query: 248 IAKKVEHNQRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETV 306
             ++V+ +Q  LD + P RD +D+FL++M +EE+NP TEF  KN++MT + L   GT TV
Sbjct: 248 TVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTV 307

Query: 307 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVI 366
           STT+ Y  LLLMK+P V+  V EE++R +G  + P   DR ++PY +AV+HE QR   ++
Sbjct: 308 STTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALV 367

Query: 367 PMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKS 426
           PM + R + + T+FR + LP+GTEV+P+LGS+L DP+ F +P++FNP  FL+  G+F+K 
Sbjct: 368 PMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKH 427

Query: 427 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRN 486
           +AF+PFS+GKR C GEGLA+ ELFLFFTT++Q F L+S   P  + + P   G   IP  
Sbjct: 428 EAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPA 487

Query: 487 YTMSFLP 493
           + +   P
Sbjct: 488 FQLQVRP 494


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  434 bits (1117), Expect = e-122
 Identities = 225/485 (46%), Positives = 306/485 (63%), Gaps = 59/485 (12%)

Query: 9   VALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPV 68
           VAL++CL+ + L+S+W+Q   +G+LP GPTPLP IGN LQL+ + M  SL   S+ YGPV
Sbjct: 5   VALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPV 64

Query: 69  FTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLR 128
           FT++ G + +VVL G++AV+EAL+D  EEFSGRG     + V KG G++FSNG+R K++R
Sbjct: 65  FTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIR 124

Query: 129 RFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFG 188
           RF + TLR+FG+GKR IE+R+QEEA  L++ LR T  +  DPTF L     NVI S++F 
Sbjct: 125 RFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFH 184

Query: 189 DRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFI 248
           DRFDYKD+ FL+L+                  E F+  ++ L  P  Q            
Sbjct: 185 DRFDYKDQRFLNLM------------------EKFNENLRILSSPWIQ------------ 214

Query: 249 AKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVST 308
                                        E+ N  +EF +++L+ T  ++F  GTET ST
Sbjct: 215 -----------------------------EKHNQQSEFTVESLIATVTDMFGAGTETTST 245

Query: 309 TLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPM 368
           TLRYG LLL+K+PEV AKV EEI+ V+G+NR P  +DR+ MPY +AV+HEIQR+ D++P 
Sbjct: 246 TLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPT 305

Query: 369 SLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDA 428
           +L   V  D KF+++ +PKGT +   L SVL +   F NP+ F+P HFL++ G FKKSD 
Sbjct: 306 NLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDY 365

Query: 429 FVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYT 488
           F+PFS GKR C GEGLARMELFLF TT++QNF LKS   PKDID++P    F  +P  Y 
Sbjct: 366 FMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQ 425

Query: 489 MSFLP 493
           + F+P
Sbjct: 426 LCFIP 430


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  384 bits (985), Expect = e-106
 Identities = 195/482 (40%), Positives = 297/482 (61%), Gaps = 8/482 (1%)

Query: 11  LLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFT 70
           LL+     +L + + +R+     PPGP  LPF+GN+  ++ EQ +  +    ++YG +F+
Sbjct: 21  LLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFS 80

Query: 71  IHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRF 130
           + LG    V++ G   ++EAL+   + F  R      + +FK  G++ S+G+  K+ RRF
Sbjct: 81  LELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRF 140

Query: 131 SIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDR 190
           ++  LR+FG+GK+ +EERIQEEA  L +A++   G   DP F ++  VSN+I SI FG+R
Sbjct: 141 TLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGER 200

Query: 191 FDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAK 250
           F+Y+D  F  LL+++  +    ++ T QLY +F  +MK LPGP Q  F   + L+ F++ 
Sbjct: 201 FEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSH 260

Query: 251 KVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTL 310
            ++ +++  +P   RDFID++L  M +   NP + F+ +NL+ +TL+LF  GTET STTL
Sbjct: 261 MIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTL 320

Query: 311 RYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSL 370
           R+  L +  +PE++ KV  EIDRVIG+ +QP    R  MPY  AVIHE+QR G++IP+++
Sbjct: 321 RWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNV 380

Query: 371 ARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFV 430
            R V  DT    + LPKGT +   L ++ RDP+ ++ P  FNP HFL E GQFKK +AF+
Sbjct: 381 PREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFL-ENGQFKKREAFM 439

Query: 431 PFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPK-------DIDVSPKHVGFATI 483
           PFSIGKR C GE LAR ELF+FFT++MQ F  +   + K        I +SP       +
Sbjct: 440 PFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAV 499

Query: 484 PR 485
           P+
Sbjct: 500 PQ 501


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  310 bits (795), Expect = 1e-84
 Identities = 184/486 (37%), Positives = 271/486 (55%), Gaps = 27/486 (5%)

Query: 10  ALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISER----- 64
           ALL+C  V +L   W +R+    +PPGPTP P +GN+  +           +S R     
Sbjct: 36  ALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAG 95

Query: 65  ------------------YGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQAT 106
                             YG +F+  +G   VVVL    +VREALV QAE FS R     
Sbjct: 96  IDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPL 155

Query: 107 FDWVFKGYGVVFSN-GERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGG 165
              V K  GVVF++ G   +Q R+FS +TLR FG+GK  +E +I EE  ++   ++  G 
Sbjct: 156 ISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGE 215

Query: 166 ANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSS 225
               P   +S  VSN+I S+ FG RFDY + EF  +L  M    +    S   L  +   
Sbjct: 216 DPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNI-CP 274

Query: 226 VMKHLP-GPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKN-PN 283
            + +LP GP ++  Q+ + +  F+ K ++ +Q +LD  +P+DFID +L+ M+EE KN  N
Sbjct: 275 WLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSN 334

Query: 284 TEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKF 343
           + F  + L     +LFI GT+T + +L +  L +  +P+V+ KVHEEI+RVIG NR P  
Sbjct: 335 SSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSL 394

Query: 344 EDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPS 403
            D+A+MPY EA I E+QR   V+P+++     ++T  + + +PKGT + P L SV RDP+
Sbjct: 395 TDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPA 454

Query: 404 FFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 463
            +  P+DF P  FL+++GQ  K + F+PF IGKR C GE LA+MELFL F ++MQ+F   
Sbjct: 455 IWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFA 514

Query: 464 SSQSPK 469
             +  K
Sbjct: 515 LPEDSK 520


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  309 bits (792), Expect = 3e-84
 Identities = 185/499 (37%), Positives = 281/499 (56%), Gaps = 19/499 (3%)

Query: 8   LVALLVCLTVMVLMSVWQQRKSK--GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65
           LV L V + + +L+     R+ +   + PPGP PLP +GN L ++ +       ++  R+
Sbjct: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65

Query: 66  GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKG---YGVVFSN-G 121
           G VF++ L    VVVL G  AVREALV   E+ + R        +  G    GV  +  G
Sbjct: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYG 125

Query: 122 ERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNV 181
              ++ RRFS++TLR+ G+GK+ +E+ + EEA  L  A     G    P   L + VSNV
Sbjct: 126 PAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNV 185

Query: 182 ISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSV--MKHLPGPQQQAFQ 239
           I+S+  G RF+Y D  FL LL +     +     +G L E+ ++V  + H+P    +  +
Sbjct: 186 IASLTCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVPVLLHIPALAGKVLR 242

Query: 240 LLQGLEDFIAKKVEHNQRTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNL 298
             +     + + +  ++ T DP   PRD  ++FL  M++ + NP + F  +NL +   +L
Sbjct: 243 FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADL 302

Query: 299 FIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHE 358
           F  G  T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  D+A MPY  AVIHE
Sbjct: 303 FSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHE 362

Query: 359 IQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLN 418
           +QRFGD++P+ +     +D + + F +PKGT +   L SVL+D + +  P  F+P+HFL+
Sbjct: 363 VQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLD 422

Query: 419 EKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHV 478
            +G F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F    S S       P H 
Sbjct: 423 AQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF----SFSVPTGQPRPSHH 478

Query: 479 G---FATIPRNYTMSFLPR 494
           G   F   P  Y +  +PR
Sbjct: 479 GVFAFLVTPSPYELCAVPR 497


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  308 bits (788), Expect = 1e-83
 Identities = 181/497 (36%), Positives = 273/497 (54%), Gaps = 24/497 (4%)

Query: 12  LVCLTVMVLMSVW-------QQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISER 64
           L+ L  + L+ +W       Q      + PPGP PLP +GN   L   Q   SLM++SER
Sbjct: 3   LLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSER 62

Query: 65  YGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERA 124
           YGPVFT+HLG ++ VVL G +AV+EAL    +E + R   A F  + +G G+ FS+G R 
Sbjct: 63  YGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARW 122

Query: 125 KQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISS 184
           +  R+F++  L   GVG+  + ++I +E   L   L G  G    P   L    SN+  +
Sbjct: 123 RAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPF-PLALLGWAPSNITFA 181

Query: 185 IVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMF----SSVMKHLPGPQQQAFQL 240
           ++FG RFDY+D  F+SLL ++  +     +   QL+ ++    + +  H P       + 
Sbjct: 182 LLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRP-----VLRK 236

Query: 241 LQGLEDFIAKKVEHNQRTLDPNSP-RDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLF 299
           ++ +   +   +E  +  + P  P   ++D+ +   Q +  +P   F   N V  TL++ 
Sbjct: 237 IEEVRAILRTLLEARRPHVCPGDPVCSYVDALI--QQGQGDDPEGLFAEANAVACTLDMV 294

Query: 300 IGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEI 359
           + GTET S TL++  LL+ +HP+V+ +V EE+DRV+G  R P+ ED+  +PY  AV+HE+
Sbjct: 295 MAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEV 354

Query: 360 QRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNE 419
           QRF  ++P  + R    DT+   F LPKGT V P+L SVL D + +  P  FNP HFL+ 
Sbjct: 355 QRFITLLP-HVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDA 413

Query: 420 KGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL--KSSQSPKDIDVSPKH 477
            G F K +AF+PFS G+R C GE LAR ELFL F  ++Q +RL      SP  +D +P  
Sbjct: 414 NGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPAR 473

Query: 478 VGFATIPRNYTMSFLPR 494
             F   PR   +  +PR
Sbjct: 474 -AFTMRPRAQALCAVPR 489


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  295 bits (754), Expect = 8e-80
 Identities = 167/483 (34%), Positives = 274/483 (56%), Gaps = 10/483 (2%)

Query: 10  ALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQL--NTEQMYNSLMKISERYGP 67
           AL + L  + +  + +QR+  G  PPGP  LPFIGN   L  ++E  +  + K S+ YG 
Sbjct: 17  ALFLLLFALGVRQLLKQRRPMG-FPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGE 75

Query: 68  VFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN-GERAKQ 126
           +F++ LG    VVL G+D V+E LV Q+E F+ R     F  + K  G++ S  G     
Sbjct: 76  IFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVD 135

Query: 127 LRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIV 186
            RR ++ + R FG G++  E +I EE  F  DA+    G   D    ++  VSN+ + I+
Sbjct: 136 HRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLII 195

Query: 187 FGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLED 246
           FG+RF Y+D +F  ++ +     +  ++++  LY  F  +     G  QQ F+    + D
Sbjct: 196 FGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVVYD 255

Query: 247 FIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETV 306
           F+++ +E       P  P+ F+D++L  M + + +P++ F  +NL+ +   L I GTET 
Sbjct: 256 FLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETT 315

Query: 307 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVI 366
           +  LR+  L +  +P ++ +V +EID ++G N +P ++D+ KMPY EAV+HE+ RF +++
Sbjct: 316 TNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPYTEAVLHEVLRFCNIV 375

Query: 367 PMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKS 426
           P+ +     +D   R + +PKGT V   L SV  D  ++ +P+ F+P+ FL+  G F K 
Sbjct: 376 PLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKK 435

Query: 427 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDI--DVSPKHVGFATIP 484
           +A VPFS+G+R+C GE LARME+FLFFT ++Q F L     P ++  D+ P+ +G    P
Sbjct: 436 EALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHL---HFPHELVPDLKPR-LGMTLQP 491

Query: 485 RNY 487
           + Y
Sbjct: 492 QPY 494


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  265 bits (676), Expect = 9e-71
 Identities = 168/495 (33%), Positives = 255/495 (51%), Gaps = 62/495 (12%)

Query: 8   LVALLVCLTVMVLMSVWQQRKSK--GKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65
           LV L V + + +L+     R+ +   + PPGP PLP +GN L ++ +       ++  R+
Sbjct: 6   LVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRF 65

Query: 66  GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAK 125
           G VF++ L    VVVL G  AVREALV   E+ + R                        
Sbjct: 66  GDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPP---------------------- 103

Query: 126 QLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSI 185
                 +   +  G G R                   + G    P   L + VSNVI+S+
Sbjct: 104 ------VPITQILGFGPR-------------------SQGRPFRPNGLLDKAVSNVIASL 138

Query: 186 VFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSV--MKHLPGPQQQAFQLLQG 243
             G RF+Y D  FL LL +     +     +G L E+ ++V  + H+P    +  +  + 
Sbjct: 139 TCGRRFEYDDPRFLRLLDLAQ---EGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKA 195

Query: 244 LEDFIAKKVEHNQRTLDP-NSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGG 302
               + + +  ++ T DP   PRD  ++FL  M++ + NP + F  +NL +   +LF  G
Sbjct: 196 FLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLCIVVADLFSAG 255

Query: 303 TETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRF 362
             T STTL +G LL++ HP+V+ +V +EID VIG+ R+P+  D+A MPY  AVIHE+QRF
Sbjct: 256 MVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRF 315

Query: 363 GDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQ 422
           GD++P+ +     +D + + F +PKGT +   L SVL+D + +  P  F+P+HFL+ +G 
Sbjct: 316 GDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGH 375

Query: 423 FKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVG--- 479
           F K +AF+PFS G+R C GE LARMELFLFFT+++Q+F    S S       P H G   
Sbjct: 376 FVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHF----SFSVPTGQPRPSHHGVFA 431

Query: 480 FATIPRNYTMSFLPR 494
           F   P  Y +  +PR
Sbjct: 432 FLVTPSPYELCAVPR 446


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  247 bits (630), Expect = 2e-65
 Identities = 154/491 (31%), Positives = 256/491 (52%), Gaps = 21/491 (4%)

Query: 1   MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
           M A+  LL +++ CL   V+ +   Q     K PPGP   P IG+ L L  +  + +L +
Sbjct: 7   MSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLG-KNPHLALSR 65

Query: 61  ISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFS- 119
           +S++YG V  I +G   VVVL G D +R+ALV Q ++F GR +  TF  +  G  + FS 
Sbjct: 66  MSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSP 125

Query: 120 -NGERAKQLRRFSIATLRDFGVGKRG-------IEERIQEEAGFLIDALRG--TGGANID 169
            +G      RR +   L+ F +           +EE + +EA  LI  L+    G  + +
Sbjct: 126 DSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFN 185

Query: 170 PTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKH 229
           P  ++  +V+NVI +I FG R+D+  +E LSL+ +     +   +        F  ++++
Sbjct: 186 PYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPA---DFIPILRY 242

Query: 230 LPGPQQQAFQ-LLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEE--KNPNTEF 286
           LP P   AF+ L +    F+ K V+ + +T +    RD  DS +   QE++  +N N + 
Sbjct: 243 LPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQL 302

Query: 287 YLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDR 346
             + ++   L+LF  G +TV+T + +  + L+ +P V+ K+ EE+D VIG++R+P+  DR
Sbjct: 303 SDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDR 362

Query: 347 AKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFS 406
           + +PYMEA I E  R    +P ++     +DT  + F++PKG  V+     +  D   + 
Sbjct: 363 SHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWV 422

Query: 407 NPQDFNPQHFLNEKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKS 464
           NP +F P+ FL   G   K  S+  + F +GKR C GE +AR E+FLF   ++Q      
Sbjct: 423 NPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSV 482

Query: 465 SQSPKDIDVSP 475
               K +D++P
Sbjct: 483 PLGVK-VDMTP 492


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  215 bits (548), Expect = 6e-56
 Identities = 145/489 (29%), Positives = 241/489 (49%), Gaps = 22/489 (4%)

Query: 3   ASGMLLVALLVCLTVMVLMSVWQQRKSKG-KLPPGPTPLPFIGNYLQLNTEQMYNSLMKI 61
           A+ +LL + + CL   VL  + + R  KG K PP P   P +G+ L L  +  + +L ++
Sbjct: 11  ATELLLASAIFCLVFWVLKGL-RPRVPKGLKSPPEPWGWPLLGHVLTLG-KNPHLALSRM 68

Query: 62  SERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFS-- 119
           S+RYG V  I +G   V+VL   D +R+ALV Q ++F GR +  T   +  G  + FS  
Sbjct: 69  SQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTD 128

Query: 120 NGERAKQLRRFSIATLRDFGVGKRG-------IEERIQEEAGFLIDALRG--TGGANIDP 170
           +G      RR +   L  F +           +EE + +EA  LI  L+    G  + DP
Sbjct: 129 SGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDP 188

Query: 171 TFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHL 230
              +  +V+NVI ++ FG  F     E LSL++      +F  T++      F  ++++L
Sbjct: 189 YNQVVVSVANVIGAMCFGQHFPESSDEMLSLVK---NTHEFVETASSGNPLDFFPILRYL 245

Query: 231 PGPQQQAFQLL-QGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLK 289
           P P  Q F+   Q    F+ K V+ + +  D NS RD   +     ++  +        +
Sbjct: 246 PNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQE 305

Query: 290 NLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKM 349
            +V    ++F  G +TV+T + +  + L+  PE++ K+ +E+D VIG+ R+P+  DR ++
Sbjct: 306 KIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQL 365

Query: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 409
           PY+EA I E  R    +P ++     +DT    F++PK   V+     V  DP  + +P 
Sbjct: 366 PYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPS 425

Query: 410 DFNPQHFLNEKG---QFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQ 466
           +F P+ FL   G       S+  + F +GKR C GE LA+ E+FLF   ++Q        
Sbjct: 426 EFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPP 485

Query: 467 SPKDIDVSP 475
             K +D++P
Sbjct: 486 GVK-VDLTP 493


>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score =  211 bits (537), Expect = 1e-54
 Identities = 149/484 (30%), Positives = 254/484 (52%), Gaps = 25/484 (5%)

Query: 7   LLVALLVCLTVMVLMSVWQQRKSKGK-LPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65
           LL+ L V  TV V   + +QR+ + +  PPGP   P IGN   +  +  + S  +++ RY
Sbjct: 23  LLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAHLSFARLARRY 81

Query: 66  GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN-GERA 124
           G VF I LG   +VVL G  A+ +ALV Q   F+ R   A+F  V  G  + F +  E  
Sbjct: 82  GDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHW 141

Query: 125 KQLRRFSIATLRDFGV----GKRGIEERIQEEAGFLIDAL-RGTG-GANIDPTFFLSRTV 178
           K  RR + + +R+F       ++ +E  +  EA  L+  L RG+  GA +DP       V
Sbjct: 142 KVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAV 201

Query: 179 SNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF 238
           +NV+S++ FG R+ + D EF  LL       +  +   G L ++    +++ P P +  F
Sbjct: 202 ANVMSAVCFGCRYSHDDPEFRELLSHNEEFGR--TVGAGSLVDVMPW-LQYFPNPVRTVF 258

Query: 239 ----QLLQGLEDFIAKKVEHNQRTLDPNS-PRDFIDSFLIRMQEEEKNPN----TEFYLK 289
               QL +   +FI  K   +  +L P + PRD +D+F++  +++    +        L+
Sbjct: 259 REFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLE 318

Query: 290 NLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKM 349
           N+  T  ++F    +T+ST L++  LL  ++P+V+ +V  E+D+V+G++R P   D+  +
Sbjct: 319 NVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNL 378

Query: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 409
           PY+ A ++E  RF   +P+++      +T    + +PK T V+    SV  DP  + NP+
Sbjct: 379 PYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPE 438

Query: 410 DFNPQHFLNEKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQ--NFRLKSS 465
           +F+P  FL++ G   K  +   + FS+GKR C GE L++M+LFLF + +    +FR   +
Sbjct: 439 NFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPN 498

Query: 466 QSPK 469
           +  K
Sbjct: 499 EPAK 502


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  192 bits (489), Expect = 4e-49
 Identities = 139/469 (29%), Positives = 240/469 (51%), Gaps = 19/469 (4%)

Query: 8   LVALLVCLTVMVLMSVWQQRKSKG-KLPPGPTPLPFIGNYLQLNTE-QMYNSLMKISERY 65
           LVALL+ LT+  L   W +R+  G K P     LP +G+   L     M+N+  K+ ++Y
Sbjct: 4   LVALLL-LTLAYLF--WPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY 60

Query: 66  GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGY-GVVFSNGERA 124
           GP++++ +G +  V++  H   +E L+ + ++FSGR + AT D       G+ F++    
Sbjct: 61  GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAH 120

Query: 125 KQL-RRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVIS 183
            QL RR ++AT   F  G + +E+ I +E   L D L    G +ID +F +   V+NVIS
Sbjct: 121 WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVIS 180

Query: 184 SIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQL-LQ 242
            I F   +   D E   +     GI    + S   L ++    +K  P    +  +  ++
Sbjct: 181 LICFNTSYKNGDPELNVIQNYNEGIID--NLSKDSLVDLVPW-LKIFPNKTLEKLKSHVK 237

Query: 243 GLEDFIAKKVEHNQRTLDPNSPRDFIDSFL-IRMQEEEKNP----NTEFYLKNLVMTTL- 296
              D + K +E+ +     +S  + +D+ +  +M  +  N     ++E    N ++TT+ 
Sbjct: 238 IRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIG 297

Query: 297 NLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVI 356
           ++F  G ET ++ +++    L+ +P+V+ K++EEID+ +G +R P   DR ++  +EA I
Sbjct: 298 DIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATI 357

Query: 357 HEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHF 416
            E+ R   V PM +  +   D+   +F + KGTEV   L ++  +   +  P  F P+ F
Sbjct: 358 REVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERF 417

Query: 417 LNEKGQ--FKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLK 463
           LN  G      S +++PF  G R+C GE LAR ELFL    ++Q F L+
Sbjct: 418 LNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLE 466


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  156 bits (395), Expect = 4e-38
 Identities = 124/471 (26%), Positives = 228/471 (48%), Gaps = 27/471 (5%)

Query: 6   MLLVALLVCLTVMV---LMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKIS 62
           MLL+ LL+ L ++    L+  W + +S    P  P        +L L    +   L+ ++
Sbjct: 1   MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLGLT 53

Query: 63  ERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGE 122
           +++GP++ +HLG + VVVL     + EA+V +  +F+GR E  T+  V + Y  + S G+
Sbjct: 54  QKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDL-SLGD 112

Query: 123 RAKQLRRFSIATLRDFGVGKRGIEERIQEE-AGFLIDALRGTGGANIDPTFFLSRTVSNV 181
            +   +     T     +G R   E + E+      + +R   G  +      S    ++
Sbjct: 113 YSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSI 172

Query: 182 ISSIVFGDRFDYKDKEFL-SLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF-Q 239
           I  + FGD+   KD   + +  + +  + +  S  + Q+ ++    ++  P P  +   Q
Sbjct: 173 ICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQ 229

Query: 240 LLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLV-MTTLNL 298
            ++  +  +  ++  ++ +L     RD +D  L  + +      +   L+  V M  ++L
Sbjct: 230 AIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDL 289

Query: 299 FIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRAKMPYMEA 354
            IGGTET + TL +  + L+ HPE++ ++ EE+D  +G     +R P ++DRA++P + A
Sbjct: 290 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNA 348

Query: 355 VIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQ 414
            I E+ R   V+P++L  R  + +    + +P+GT + P L     D + +  P +F P 
Sbjct: 349 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 408

Query: 415 HFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSS 465
            FL E G   K+   + F  G R C GE LAR+ELF+  T ++Q F L  S
Sbjct: 409 RFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 455


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  127 bits (320), Expect = 2e-29
 Identities = 113/471 (23%), Positives = 219/471 (46%), Gaps = 57/471 (12%)

Query: 6   MLLVALLVCLTVMV---LMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKIS 62
           MLL+ LL+ L ++    L+  W + +S    P  P        +L L    +   L+ ++
Sbjct: 1   MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLGLT 53

Query: 63  ERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGE 122
           +++GP++ +HLG            +++ LV +       G+   +  ++K +        
Sbjct: 54  QKFGPIYRLHLG------------LQDKLVSRNYPDLSLGD---YSLLWKAH-------- 90

Query: 123 RAKQLRRFSIAT-LRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNV 181
             K+L R ++   +RD       +E  +++      + +R   G  +      S    ++
Sbjct: 91  --KKLTRSALLLGIRD------SMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSI 142

Query: 182 ISSIVFGDRFDYKDKEFL-SLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF-Q 239
           I  + FGD+   KD   + +  + +  + +  S  + Q+ ++    ++  P P  +   Q
Sbjct: 143 ICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQ 199

Query: 240 LLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLV-MTTLNL 298
            ++  +  +  ++  ++ +L     RD +D  L  + +      +   L+  V M  ++L
Sbjct: 200 AIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDL 259

Query: 299 FIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRAKMPYMEA 354
            IGGTET + TL +  + L+ HPE++ ++ EE+D  +G     +R P ++DRA++P + A
Sbjct: 260 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNA 318

Query: 355 VIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQ 414
            I E+ R   V+P++L  R  + +    + +P+GT + P L     D + +  P +F P 
Sbjct: 319 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 378

Query: 415 HFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSS 465
            FL E G   K+   + F  G R C GE LAR+ELF+  T ++Q F L  S
Sbjct: 379 RFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 425


>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score =  124 bits (312), Expect = 2e-28
 Identities = 124/500 (24%), Positives = 224/500 (44%), Gaps = 54/500 (10%)

Query: 2   LASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTE--QMYNSLM 59
           LA   L+++LL    V      WQQ +    +P      P +G+ L +  +  + +  ++
Sbjct: 24  LAGASLVLSLLQ--RVASYARKWQQMRP---IPTVARAYPLVGHALLMKPDGREFFQQII 78

Query: 60  KISERYG--PVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVV 117
           + +E Y   P+  + +GP  +V L   + V   L    +       +    W+  G G++
Sbjct: 79  EYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWL--GLGLL 136

Query: 118 FSNGERAKQLRR-----FSIATLRDFGVGKRGIEERIQEEAGFLIDAL-RGTGGANIDPT 171
            S G + +  R+     F    L DF        + + E+A  L+  L +       +  
Sbjct: 137 TSTGNKWRSRRKMLTPTFHFTILEDF-------LDIMNEQANILVKKLEKHINQEAFNCF 189

Query: 172 FFLSRTVSNVISSIVFGDRFDYK---DKEFL-SLLRMMLGIFQFTSTSTGQL---YEMFS 224
           F+++    ++I     G     +   D E++ ++ RM   IF+        L   Y MF 
Sbjct: 190 FYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFK 249

Query: 225 SVMKHLPGPQQQAFQLLQGLED-FIAKKVEHNQRTLD-----------PNSPRDFIDSFL 272
              +H     +++ Q+L    +  IA++        D            N  R F+D  L
Sbjct: 250 EGWEH-----KKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLD-LL 303

Query: 273 IRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEID 332
           + + ++E N  +   ++  V T +     G +T +  + +   LL  +PEV+ KV  E+D
Sbjct: 304 LSVTDDEGNRLSHEDIREEVDTFM---FEGHDTTAAAINWSLYLLGSNPEVQKKVDHELD 360

Query: 333 RVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEV 391
            V GK+ +P   ED  K+ Y+E VI E  R    +P+  AR V +D +   + + KGTE 
Sbjct: 361 DVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL-FARSVSEDCEVAGYRVLKGTEA 419

Query: 392 YPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFL 451
             +  ++ RDP +F NP++F P+ F  E  Q +   A+VPFS G RNC G+  A ME   
Sbjct: 420 VIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKT 479

Query: 452 FFTTVMQNFRLKSSQSPKDI 471
             + ++++F ++S+Q  +++
Sbjct: 480 ILSCILRHFWIESNQKREEL 499


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  119 bits (298), Expect = 6e-27
 Identities = 123/482 (25%), Positives = 207/482 (42%), Gaps = 59/482 (12%)

Query: 11  LLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQ-MYNSLMKISERYGPVF 69
           L V L ++ L         K    PGPTPLPF+GN L  +    M++  M+  ++YG V+
Sbjct: 15  LAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFD--MECHKKYGKVW 72

Query: 70  TIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWV-FKGYGVVFSNGERAKQLR 128
             + G + V+ +   D ++  LV +   +S    +  F  V F    +  +  E  K+LR
Sbjct: 73  GFYDGQQPVLAITDPDMIKTVLVKEC--YSVFTNRRPFGPVGFMKSAISIAEDEEWKRLR 130

Query: 129 R-----FSIATLRDFG--VGKRG--IEERIQEEA-------------GFLIDALRGTG-G 165
                 F+   L++    + + G  +   ++ EA              + +D +  T  G
Sbjct: 131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFG 190

Query: 166 ANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSS 225
            NID    L+      + +     RFD+ D  FLS+      +F F              
Sbjct: 191 VNIDS---LNNPQDPFVENTKKLLRFDFLDPFFLSIT-----VFPFLIP--------ILE 234

Query: 226 VMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTE 285
           V+     P++        + +F+ K V+  + +   ++ +  +D FL  M + + +  TE
Sbjct: 235 VLNICVFPRE--------VTNFLRKSVKRMKESRLEDTQKHRVD-FLQLMIDSQNSKETE 285

Query: 286 FYLK----NLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQP 341
            +       LV  ++     G ET S+ L +    L  HP+V+ K+ EEID V+     P
Sbjct: 286 SHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPP 345

Query: 342 KFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRD 401
            ++   +M Y++ V++E  R    I M L R  KKD +    F+PKG  V     ++ RD
Sbjct: 346 TYDTVLQMEYLDMVVNETLRLFP-IAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRD 404

Query: 402 PSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFR 461
           P +++ P+ F P+ F  +         + PF  G RNC G   A M + L    V+QNF 
Sbjct: 405 PKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFS 464

Query: 462 LK 463
            K
Sbjct: 465 FK 466


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  115 bits (288), Expect = 9e-26
 Identities = 114/469 (24%), Positives = 202/469 (43%), Gaps = 61/469 (13%)

Query: 35  PGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQ 94
           PGPTPLP +GN L    + ++    +  ++YG ++  + G   V+ +   D +R  LV +
Sbjct: 39  PGPTPLPLLGNVLSYR-QGLWKFDTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKE 97

Query: 95  AEE-FSGRGEQATFDWVFKGYGVVFSNGERAKQLRR-----FSIATLRDFG--VGKRG-- 144
               F+ R         F    +  +  E  K++R      F+   L++    + + G  
Sbjct: 98  CYSVFTNRRSLGPVG--FMKSAISLAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDV 155

Query: 145 IEERIQEEA-------------GFLIDALRGTG-GANIDPTFFLSRTVSNVISSIVFGDR 190
           +   ++ EA              + +D + GT  G NID    L+      + S     +
Sbjct: 156 LVRNLRREAEKGKPVTLKDIFGAYSMDVITGTSFGVNIDS---LNNPQDPFVESTKKFLK 212

Query: 191 FDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAK 250
           F + D  FLS++     +F F       L  +F ++   L           +   +F++K
Sbjct: 213 FGFLDPLFLSII-----LFPF-------LTPVFEALNVSL---------FPKDTINFLSK 251

Query: 251 KVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLK----NLVMTTLNLFIGGTETV 306
            V   +++   +  +  +D FL  M + + +  TE +       L   ++     G ET 
Sbjct: 252 SVNRMKKSRLNDKQKHRLD-FLQLMIDSQNSKETESHKALSDLELAAQSIIFIFAGYETT 310

Query: 307 STTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVI 366
           S+ L +    L  HP+V+ K+ +EID V+     P ++   +M Y++ V++E  R   V 
Sbjct: 311 SSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVVNETLRLFPV- 369

Query: 367 PMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKS 426
            + L R  KKD +    F+PKG+ V     ++  DP +++ P++F P+ F  +K      
Sbjct: 370 AIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFSKKKDSIDPY 429

Query: 427 DAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRL---KSSQSPKDID 472
             + PF  G RNC G   A M + L    V+QNF     K +Q P  +D
Sbjct: 430 -IYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLD 477


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  115 bits (288), Expect = 9e-26
 Identities = 105/453 (23%), Positives = 192/453 (42%), Gaps = 22/453 (4%)

Query: 35  PGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQ 94
           PGPTPLPF+G  L      ++N   + +E+YG ++ ++ G + ++V+   D ++  LV +
Sbjct: 39  PGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97

Query: 95  AEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAG 154
                   +       F    + F+  E  K++R  ++ +     V  + +   I +   
Sbjct: 98  CYSVF-TNQMPLGPMGFLKSALSFAEDEEWKRIR--TLLSPAFTSVKFKEMVPIISQCGD 154

Query: 155 FLIDALR--GTGGANIDPTFFLSRTVSNVISSIVFG---DRFDYKDKEFLSLLRMMLGI- 208
            L+ +LR       +I+   F      +VI+  +FG   D  +     FL  ++ +L + 
Sbjct: 155 MLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLD 214

Query: 209 FQFTSTSTGQLYEMFSSVMKHLP---GPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPR 265
           F         L+   + V + L     P+     L   +E     +++  Q+        
Sbjct: 215 FLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQK-----HRV 269

Query: 266 DFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEA 325
           DF    +     +E   +       LV  ++ +     +T STTL +    L  HP+V+ 
Sbjct: 270 DFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQ 329

Query: 326 KVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFL 385
           K+ EEID V+       ++   +M Y++ V++E  R   V+   + R  KKD +    F+
Sbjct: 330 KLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVV-SRVTRVCKKDIEINGVFI 388

Query: 386 PKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLA 445
           PKG  V   + ++  DP +++ P+ F P+ F  +         ++PF  G RNC G   A
Sbjct: 389 PKGLAVMVPIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFA 448

Query: 446 RMELFLFFTTVMQNFRL---KSSQSPKDIDVSP 475
              + L     +QNF     K +Q P  +D  P
Sbjct: 449 LTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 481


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  112 bits (279), Expect = 1e-24
 Identities = 105/454 (23%), Positives = 194/454 (42%), Gaps = 23/454 (5%)

Query: 35  PGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQ 94
           PGPTPLPF+G  L      ++N   + +E+YG ++ ++ G + ++V+   D ++  LV +
Sbjct: 39  PGPTPLPFLGTIL-FYLRGLWNFDRECNEKYGEMWGLYEGQQPMLVIMDPDMIKTVLVKE 97

Query: 95  AEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAG 154
                   +       F    + F+  E  K++R  ++ +     V  + +   I +   
Sbjct: 98  CYSVF-TNQMPLGPMGFLKSALSFAEDEEWKRIR--TLLSPAFTSVKFKEMVPIISQCGD 154

Query: 155 FLIDALR--GTGGANIDPTFFLSRTVSNVISSIVFG---DRFDYKDKEFLSLLRMMLGI- 208
            L+ +LR       +I+   F      +VI+  +FG   D  +     FL  ++ +L + 
Sbjct: 155 MLVRSLRQEAENSKSINLKDFFGAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLD 214

Query: 209 FQFTSTSTGQLYEMFSSVMKHLP---GPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPR 265
           F         L+   + V + L     P+     L   +E     +++  Q+        
Sbjct: 215 FLDPFLLLISLFPFLTPVFEALNIGLFPKDVTHFLKNSIERMKESRLKDKQK-----HRV 269

Query: 266 DFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEA 325
           DF    +     +E   +       LV  ++ +     +T STTL +    L  HP+V+ 
Sbjct: 270 DFFQQMIDSQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQ 329

Query: 326 KVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFL 385
           K+ EEID V+       ++   +M Y++ V++E  R   V+   + R  KKD +    F+
Sbjct: 330 KLQEEIDAVLPNKAPVTYDALVQMEYLDMVVNETLRLFPVV-SRVTRVCKKDIEINGVFI 388

Query: 386 PKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFK-KSDAFVPFSIGKRNCFGEGL 444
           PKG  V   + ++  DP +++ P+ F P+   ++K +       ++PF  G RNC G   
Sbjct: 389 PKGLAVMVPIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRF 448

Query: 445 ARMELFLFFTTVMQNFRL---KSSQSPKDIDVSP 475
           A   + L     +QNF     K +Q P  +D  P
Sbjct: 449 ALTNIKLAVIRALQNFSFKPCKETQIPLKLDNLP 482


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.140    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,219,524
Number of Sequences: 37866
Number of extensions: 804967
Number of successful extensions: 2092
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 66
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 1903
Number of HSP's gapped (non-prelim): 102
length of query: 494
length of database: 18,247,518
effective HSP length: 106
effective length of query: 388
effective length of database: 14,233,722
effective search space: 5522684136
effective search space used: 5522684136
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.