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Search of human proteins with 18860859
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18860859 protein tyrosine phosphatase, receptor type, E
isoform 2 [Homo sapiens]
(642 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo... 1319 0.0
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor... 1295 0.0
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo... 924 0.0
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor... 924 0.0
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo... 924 0.0
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 551 e-157
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 551 e-157
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 550 e-156
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 550 e-156
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 550 e-156
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 550 e-156
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 550 e-156
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ... 549 e-156
gi|104487297 protein tyrosine phosphatase, receptor type, sigma ... 549 e-156
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ... 549 e-156
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 549 e-156
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo... 433 e-121
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo... 433 e-121
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo... 433 e-121
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo... 426 e-119
gi|157419150 protein tyrosine phosphatase, receptor type, M isof... 423 e-118
gi|157419152 protein tyrosine phosphatase, receptor type, M isof... 423 e-118
gi|148539860 protein tyrosine phosphatase, receptor type, T isof... 421 e-117
gi|148539858 protein tyrosine phosphatase, receptor type, T isof... 421 e-117
gi|208431815 protein tyrosine phosphatase, receptor type, K isof... 420 e-117
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p... 378 e-105
gi|110735404 protein tyrosine phosphatase, receptor type, U isof... 377 e-104
gi|110735402 protein tyrosine phosphatase, receptor type, U isof... 377 e-104
gi|194097398 protein tyrosine phosphatase, receptor type, G prec... 374 e-103
gi|110735406 protein tyrosine phosphatase, receptor type, U isof... 370 e-102
>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform
2 [Homo sapiens]
Length = 642
Score = 1319 bits (3413), Expect = 0.0
Identities = 642/642 (100%), Positives = 642/642 (100%)
Query: 1 MSNRSSFSRLTWFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVE 60
MSNRSSFSRLTWFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVE
Sbjct: 1 MSNRSSFSRLTWFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVE 60
Query: 61 HLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL 120
HLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL
Sbjct: 61 HLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL 120
Query: 121 SQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 180
SQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE
Sbjct: 121 SQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 180
Query: 181 RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 240
RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF
Sbjct: 181 RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 240
Query: 241 TSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAE 300
TSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAE
Sbjct: 241 TSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAE 300
Query: 301 QKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTT 360
QKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTT
Sbjct: 301 QKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTT 360
Query: 361 THFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEY 420
THFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEY
Sbjct: 361 THFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEY 420
Query: 421 TDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQ 480
TDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQ
Sbjct: 421 TDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQ 480
Query: 481 YWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI 540
YWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI
Sbjct: 481 YWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI 540
Query: 541 GIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDV 600
GIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDV
Sbjct: 541 GIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDV 600
Query: 601 FQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK 642
FQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK
Sbjct: 601 FQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK 642
>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
precursor [Homo sapiens]
Length = 700
Score = 1295 bits (3350), Expect = 0.0
Identities = 630/630 (100%), Positives = 630/630 (100%)
Query: 13 FRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSAD 72
FRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSAD
Sbjct: 71 FRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSAD 130
Query: 73 DCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYI 132
DCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYI
Sbjct: 131 DCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYI 190
Query: 133 NASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD 192
NASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD
Sbjct: 191 NASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD 250
Query: 193 QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTP 252
QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTP
Sbjct: 251 QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTP 310
Query: 253 IGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRI 312
IGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRI
Sbjct: 311 IGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRI 370
Query: 313 RNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEF 372
RNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEF
Sbjct: 371 RNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEF 430
Query: 373 RKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGY 432
RKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGY
Sbjct: 431 RKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGY 490
Query: 433 RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGE 492
RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGE
Sbjct: 491 RQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGE 550
Query: 493 ITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDL 552
ITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDL
Sbjct: 551 ITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDL 610
Query: 553 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 612
IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP
Sbjct: 611 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 670
Query: 613 HMVQTLEQYEFCYKVVQDFIDIFSDYANFK 642
HMVQTLEQYEFCYKVVQDFIDIFSDYANFK
Sbjct: 671 HMVQTLEQYEFCYKVVQDFIDIFSDYANFK 700
>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 924 bits (2387), Expect = 0.0
Identities = 449/632 (71%), Positives = 531/632 (84%), Gaps = 8/632 (1%)
Query: 13 FRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSAD 72
F+K ++A ++ ++ NG E+ E Q V LL+RSPS +KY P+PV+ LEEEI R AD
Sbjct: 168 FKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMAD 227
Query: 73 DCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYI 132
D K FREEFN+LP+ IQ T E A+KEEN+EKNRY NILP DHSRV L+ ++G+P SDYI
Sbjct: 228 DNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYI 287
Query: 133 NASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD 192
NAS+I+GY+EKNKFIAAQGPK+ETVNDFWRM+WEQ +ATIVM+TNLKERKE KC QYWPD
Sbjct: 288 NASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD 347
Query: 193 QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPD--GCKAPRLVSQLHFTSWPDFGVPF 250
QGCWTYGNIRV VED VLVDYT+RKFCIQ Q+ D K RL++Q HFTSWPDFGVPF
Sbjct: 348 QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQ-QVGDMTNRKPQRLITQFHFTSWPDFGVPF 406
Query: 251 TPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVS 310
TPIGMLKFLKKVK NP +AG IVVHCSAGVGRTGTF+VIDAM+ MMH E+KVDV+ FVS
Sbjct: 407 TPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVS 466
Query: 311 RIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEE 370
RIR QR QMVQTDMQY FIYQALLE+YLYGDTEL+V+SLE HLQ ++ GLEE
Sbjct: 467 RIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEE 526
Query: 371 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 430
EF+KLT+++I + MRTGNLPANMKK RV+QIIPY+FNRVI+ +KRG+E TDY+NASFID
Sbjct: 527 EFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFID 586
Query: 431 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTH 490
GYRQKD +IA+QGPL HT+EDFWRMIWEWKS +IVMLTE++ER Q+KC QYWP++G V++
Sbjct: 587 GYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSY 646
Query: 491 GEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMI 550
G+IT+E+K + E+ ++RD LVT +E + R +RQFHFHGWPE+GIP++GKGMI
Sbjct: 647 GDITVELKKEEECESYTVRDLLVT-----NTRENKSRQIRQFHFHGWPEVGIPSDGKGMI 701
Query: 551 DLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQ 610
+IAAVQKQQQQ+GNHPITVHCSAGAGRTGTF ALS +LERVKAEG+LDVFQ VKSLRLQ
Sbjct: 702 SIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQ 761
Query: 611 RPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK 642
RPHMVQTLEQYEFCYKVVQ++ID FSDYANFK
Sbjct: 762 RPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK 793
>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
precursor [Homo sapiens]
Length = 802
Score = 924 bits (2387), Expect = 0.0
Identities = 449/632 (71%), Positives = 531/632 (84%), Gaps = 8/632 (1%)
Query: 13 FRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSAD 72
F+K ++A ++ ++ NG E+ E Q V LL+RSPS +KY P+PV+ LEEEI R AD
Sbjct: 177 FKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMAD 236
Query: 73 DCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYI 132
D K FREEFN+LP+ IQ T E A+KEEN+EKNRY NILP DHSRV L+ ++G+P SDYI
Sbjct: 237 DNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYI 296
Query: 133 NASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD 192
NAS+I+GY+EKNKFIAAQGPK+ETVNDFWRM+WEQ +ATIVM+TNLKERKE KC QYWPD
Sbjct: 297 NASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD 356
Query: 193 QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPD--GCKAPRLVSQLHFTSWPDFGVPF 250
QGCWTYGNIRV VED VLVDYT+RKFCIQ Q+ D K RL++Q HFTSWPDFGVPF
Sbjct: 357 QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQ-QVGDMTNRKPQRLITQFHFTSWPDFGVPF 415
Query: 251 TPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVS 310
TPIGMLKFLKKVK NP +AG IVVHCSAGVGRTGTF+VIDAM+ MMH E+KVDV+ FVS
Sbjct: 416 TPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVS 475
Query: 311 RIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEE 370
RIR QR QMVQTDMQY FIYQALLE+YLYGDTEL+V+SLE HLQ ++ GLEE
Sbjct: 476 RIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEE 535
Query: 371 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 430
EF+KLT+++I + MRTGNLPANMKK RV+QIIPY+FNRVI+ +KRG+E TDY+NASFID
Sbjct: 536 EFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFID 595
Query: 431 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTH 490
GYRQKD +IA+QGPL HT+EDFWRMIWEWKS +IVMLTE++ER Q+KC QYWP++G V++
Sbjct: 596 GYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSY 655
Query: 491 GEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMI 550
G+IT+E+K + E+ ++RD LVT +E + R +RQFHFHGWPE+GIP++GKGMI
Sbjct: 656 GDITVELKKEEECESYTVRDLLVT-----NTRENKSRQIRQFHFHGWPEVGIPSDGKGMI 710
Query: 551 DLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQ 610
+IAAVQKQQQQ+GNHPITVHCSAGAGRTGTF ALS +LERVKAEG+LDVFQ VKSLRLQ
Sbjct: 711 SIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQ 770
Query: 611 RPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK 642
RPHMVQTLEQYEFCYKVVQ++ID FSDYANFK
Sbjct: 771 RPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK 802
>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform
2 precursor [Homo sapiens]
Length = 793
Score = 924 bits (2387), Expect = 0.0
Identities = 449/632 (71%), Positives = 531/632 (84%), Gaps = 8/632 (1%)
Query: 13 FRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSAD 72
F+K ++A ++ ++ NG E+ E Q V LL+RSPS +KY P+PV+ LEEEI R AD
Sbjct: 168 FKKYKQAGSHSNSFRLSNGRTEDVEPQSVPLLARSPSTNRKYPPLPVDKLEEEINRRMAD 227
Query: 73 DCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYI 132
D K FREEFN+LP+ IQ T E A+KEEN+EKNRY NILP DHSRV L+ ++G+P SDYI
Sbjct: 228 DNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYI 287
Query: 133 NASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPD 192
NAS+I+GY+EKNKFIAAQGPK+ETVNDFWRM+WEQ +ATIVM+TNLKERKE KC QYWPD
Sbjct: 288 NASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD 347
Query: 193 QGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPD--GCKAPRLVSQLHFTSWPDFGVPF 250
QGCWTYGNIRV VED VLVDYT+RKFCIQ Q+ D K RL++Q HFTSWPDFGVPF
Sbjct: 348 QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQ-QVGDMTNRKPQRLITQFHFTSWPDFGVPF 406
Query: 251 TPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVS 310
TPIGMLKFLKKVK NP +AG IVVHCSAGVGRTGTF+VIDAM+ MMH E+KVDV+ FVS
Sbjct: 407 TPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVS 466
Query: 311 RIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEE 370
RIR QR QMVQTDMQY FIYQALLE+YLYGDTEL+V+SLE HLQ ++ GLEE
Sbjct: 467 RIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEE 526
Query: 371 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 430
EF+KLT+++I + MRTGNLPANMKK RV+QIIPY+FNRVI+ +KRG+E TDY+NASFID
Sbjct: 527 EFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFID 586
Query: 431 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTH 490
GYRQKD +IA+QGPL HT+EDFWRMIWEWKS +IVMLTE++ER Q+KC QYWP++G V++
Sbjct: 587 GYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSY 646
Query: 491 GEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMI 550
G+IT+E+K + E+ ++RD LVT +E + R +RQFHFHGWPE+GIP++GKGMI
Sbjct: 647 GDITVELKKEEECESYTVRDLLVT-----NTRENKSRQIRQFHFHGWPEVGIPSDGKGMI 701
Query: 551 DLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQ 610
+IAAVQKQQQQ+GNHPITVHCSAGAGRTGTF ALS +LERVKAEG+LDVFQ VKSLRLQ
Sbjct: 702 SIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQ 761
Query: 611 RPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK 642
RPHMVQTLEQYEFCYKVVQ++ID FSDYANFK
Sbjct: 762 RPHMVQTLEQYEFCYKVVQEYIDAFSDYANFK 793
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
precursor [Homo sapiens]
Length = 1907
Score = 551 bits (1420), Expect = e-157
Identities = 287/632 (45%), Positives = 402/632 (63%), Gaps = 14/632 (2%)
Query: 13 FRKQRKAVVSTSDKK---MPNGIL-EEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRI 68
F+++R S+ D++ + + +L + + L+ G + + PIP+ L + I
Sbjct: 1284 FKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIER 1343
Query: 69 RSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPC 128
A+D +F +E+ S+ G Q T+E +N E N+ KNRY N++ DHSRVIL+ +DG+P
Sbjct: 1344 LKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG 1402
Query: 129 SDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQ 188
SDYINA+YIDGY+++N +IA QGP ET+ DFWRMVWEQ++AT+VM+T L+E+ KC Q
Sbjct: 1403 SDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ 1462
Query: 189 YWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGV 248
YWP +G T G I+V + D V L YT+R F + G R + Q F +WPD GV
Sbjct: 1463 YWPARGTETCGLIQVTLLDTVELATYTVRTFALHKS---GSSEKRELRQFQFMAWPDHGV 1519
Query: 249 PFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEF 308
P P +L FL++VK NP+ AGP+VVHCSAGVGRTG FIVIDAM+ M E+ VD++
Sbjct: 1520 PEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGH 1579
Query: 309 VSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGL 368
V+ +R+QR MVQT+ QY FI++ALLE G TE+ +L H+Q + +
Sbjct: 1580 VTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAM 1639
Query: 369 EEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASF 428
E EF+ L + + + NLP N K R++ I+PY+ RV L RG E +DYINASF
Sbjct: 1640 ELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASF 1699
Query: 429 IDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSV 488
+DGYRQ+ +IATQGPLA + EDFWRM+WE S IVMLT+++E ++KC+QYWP E S
Sbjct: 1700 LDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA 1759
Query: 489 THGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKG 548
+ ++ + +R+F VT ++ Q R +RQF F WPE G+P G+G
Sbjct: 1760 RYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTIRQFQFTDWPEQGVPKTGEG 1814
Query: 549 MIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 607
ID I V K ++Q G + PITVHCSAG GRTG FI LS +LER++ EG++D+FQ VK+L
Sbjct: 1815 FIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTL 1874
Query: 608 RLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
R QRP MVQT +QY+ CY+ +++ F YA
Sbjct: 1875 RTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1906
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
precursor [Homo sapiens]
Length = 1898
Score = 551 bits (1420), Expect = e-157
Identities = 287/632 (45%), Positives = 402/632 (63%), Gaps = 14/632 (2%)
Query: 13 FRKQRKAVVSTSDKK---MPNGIL-EEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRI 68
F+++R S+ D++ + + +L + + L+ G + + PIP+ L + I
Sbjct: 1275 FKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIER 1334
Query: 69 RSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPC 128
A+D +F +E+ S+ G Q T+E +N E N+ KNRY N++ DHSRVIL+ +DG+P
Sbjct: 1335 LKANDGLKFSQEYESIDPGQ-QFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPG 1393
Query: 129 SDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQ 188
SDYINA+YIDGY+++N +IA QGP ET+ DFWRMVWEQ++AT+VM+T L+E+ KC Q
Sbjct: 1394 SDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQ 1453
Query: 189 YWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGV 248
YWP +G T G I+V + D V L YT+R F + G R + Q F +WPD GV
Sbjct: 1454 YWPARGTETCGLIQVTLLDTVELATYTVRTFALHKS---GSSEKRELRQFQFMAWPDHGV 1510
Query: 249 PFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEF 308
P P +L FL++VK NP+ AGP+VVHCSAGVGRTG FIVIDAM+ M E+ VD++
Sbjct: 1511 PEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGH 1570
Query: 309 VSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGL 368
V+ +R+QR MVQT+ QY FI++ALLE G TE+ +L H+Q + +
Sbjct: 1571 VTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAM 1630
Query: 369 EEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASF 428
E EF+ L + + + NLP N K R++ I+PY+ RV L RG E +DYINASF
Sbjct: 1631 ELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASF 1690
Query: 429 IDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSV 488
+DGYRQ+ +IATQGPLA + EDFWRM+WE S IVMLT+++E ++KC+QYWP E S
Sbjct: 1691 LDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSA 1750
Query: 489 THGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKG 548
+ ++ + +R+F VT ++ Q R +RQF F WPE G+P G+G
Sbjct: 1751 RYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTIRQFQFTDWPEQGVPKTGEG 1805
Query: 549 MIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 607
ID I V K ++Q G + PITVHCSAG GRTG FI LS +LER++ EG++D+FQ VK+L
Sbjct: 1806 FIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTL 1865
Query: 608 RLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
R QRP MVQT +QY+ CY+ +++ F YA
Sbjct: 1866 RTQRPAMVQTEDQYQLCYRAALEYLGSFDHYA 1897
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
precursor [Homo sapiens]
Length = 1502
Score = 550 bits (1416), Expect = e-156
Identities = 282/591 (47%), Positives = 384/591 (64%), Gaps = 10/591 (1%)
Query: 50 GPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPN 109
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KNRY N
Sbjct: 920 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYAN 978
Query: 110 ILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKS 169
++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+WEQ+S
Sbjct: 979 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1038
Query: 170 ATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 229
AT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F + +G
Sbjct: 1039 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK---NGS 1095
Query: 230 KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 289
R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG FIV
Sbjct: 1096 SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV 1155
Query: 290 IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSL 349
IDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+ +L
Sbjct: 1156 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNL 1215
Query: 350 EKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNR 409
++Q + T + G+E EF++L + + + NLP N K R++ I+PY+ R
Sbjct: 1216 YAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1275
Query: 410 VILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTE 469
V L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+
Sbjct: 1276 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1335
Query: 470 VQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVV 529
++E ++KC+QYWP E S + ++ + +R+F VT ++ Q R V
Sbjct: 1336 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTV 1390
Query: 530 RQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNI 588
RQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +
Sbjct: 1391 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1450
Query: 589 LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 1451 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1501
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 550 bits (1416), Expect = e-156
Identities = 282/591 (47%), Positives = 384/591 (64%), Gaps = 10/591 (1%)
Query: 50 GPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPN 109
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KNRY N
Sbjct: 1330 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYAN 1388
Query: 110 ILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKS 169
++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+WEQ+S
Sbjct: 1389 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1448
Query: 170 ATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 229
AT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F + +G
Sbjct: 1449 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK---NGS 1505
Query: 230 KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 289
R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG FIV
Sbjct: 1506 SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV 1565
Query: 290 IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSL 349
IDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+ +L
Sbjct: 1566 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNL 1625
Query: 350 EKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNR 409
++Q + T + G+E EF++L + + + NLP N K R++ I+PY+ R
Sbjct: 1626 YAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1685
Query: 410 VILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTE 469
V L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+
Sbjct: 1686 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1745
Query: 470 VQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVV 529
++E ++KC+QYWP E S + ++ + +R+F VT ++ Q R V
Sbjct: 1746 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTV 1800
Query: 530 RQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNI 588
RQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +
Sbjct: 1801 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1860
Query: 589 LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 1861 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1911
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
precursor [Homo sapiens]
Length = 1899
Score = 550 bits (1416), Expect = e-156
Identities = 282/591 (47%), Positives = 384/591 (64%), Gaps = 10/591 (1%)
Query: 50 GPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPN 109
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KNRY N
Sbjct: 1317 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYAN 1375
Query: 110 ILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKS 169
++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+WEQ+S
Sbjct: 1376 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1435
Query: 170 ATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 229
AT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F + +G
Sbjct: 1436 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK---NGS 1492
Query: 230 KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 289
R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG FIV
Sbjct: 1493 SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV 1552
Query: 290 IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSL 349
IDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+ +L
Sbjct: 1553 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNL 1612
Query: 350 EKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNR 409
++Q + T + G+E EF++L + + + NLP N K R++ I+PY+ R
Sbjct: 1613 YAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1672
Query: 410 VILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTE 469
V L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+
Sbjct: 1673 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1732
Query: 470 VQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVV 529
++E ++KC+QYWP E S + ++ + +R+F VT ++ Q R V
Sbjct: 1733 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTV 1787
Query: 530 RQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNI 588
RQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +
Sbjct: 1788 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1847
Query: 589 LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 1848 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1898
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
precursor [Homo sapiens]
Length = 1903
Score = 550 bits (1416), Expect = e-156
Identities = 282/591 (47%), Positives = 384/591 (64%), Gaps = 10/591 (1%)
Query: 50 GPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPN 109
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KNRY N
Sbjct: 1321 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYAN 1379
Query: 110 ILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKS 169
++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+WEQ+S
Sbjct: 1380 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1439
Query: 170 ATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 229
AT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F + +G
Sbjct: 1440 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK---NGS 1496
Query: 230 KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 289
R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG FIV
Sbjct: 1497 SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV 1556
Query: 290 IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSL 349
IDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+ +L
Sbjct: 1557 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNL 1616
Query: 350 EKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNR 409
++Q + T + G+E EF++L + + + NLP N K R++ I+PY+ R
Sbjct: 1617 YAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1676
Query: 410 VILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTE 469
V L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+
Sbjct: 1677 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1736
Query: 470 VQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVV 529
++E ++KC+QYWP E S + ++ + +R+F VT ++ Q R V
Sbjct: 1737 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTV 1791
Query: 530 RQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNI 588
RQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +
Sbjct: 1792 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1851
Query: 589 LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 1852 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1902
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
precursor [Homo sapiens]
Length = 1501
Score = 550 bits (1416), Expect = e-156
Identities = 282/591 (47%), Positives = 384/591 (64%), Gaps = 10/591 (1%)
Query: 50 GPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPN 109
G + PIP+ L + I A+D +F +E+ S+ G Q T+E +N E N+ KNRY N
Sbjct: 919 GMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYAN 977
Query: 110 ILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKS 169
++ DHSRV+LS ++GIP SDY+NA+YIDGY+++N +IA QG ET DFWRM+WEQ+S
Sbjct: 978 VIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRS 1037
Query: 170 ATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGC 229
AT+VM+T L+ER KC QYWP +G T+G ++V + D V L Y +R F + +G
Sbjct: 1038 ATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYK---NGS 1094
Query: 230 KAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIV 289
R V Q FT+WPD GVP P L FL++VKT NP AGP+VVHCSAGVGRTG FIV
Sbjct: 1095 SEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIV 1154
Query: 290 IDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSL 349
IDAM+ + E+ VD++ V+ +R QR MVQT+ QY FI+ ALLE G+TE+ +L
Sbjct: 1155 IDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNL 1214
Query: 350 EKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNR 409
++Q + T + G+E EF++L + + + NLP N K R++ I+PY+ R
Sbjct: 1215 YAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTR 1274
Query: 410 VILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTE 469
V L RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+
Sbjct: 1275 VCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTK 1334
Query: 470 VQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVV 529
++E ++KC+QYWP E S + ++ + +R+F VT ++ Q R V
Sbjct: 1335 LREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTV 1389
Query: 530 RQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNI 588
RQF F WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +
Sbjct: 1390 RQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIV 1449
Query: 589 LERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
LER++ EG++D+FQ VK LR QRP MVQT +QY+F Y+ +++ F YA
Sbjct: 1450 LERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYA 1500
>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
isoform 4 precursor [Homo sapiens]
Length = 1505
Score = 549 bits (1414), Expect = e-156
Identities = 283/585 (48%), Positives = 381/585 (65%), Gaps = 10/585 (1%)
Query: 56 PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115
PIP+ + E A+D + +E+ S+ G Q T+E +N E N+ KNRY N++ DH
Sbjct: 929 PIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDH 987
Query: 116 SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175
SRVIL ++GI SDYINA+Y+DGY+ +N +IA QGP ET DFWRMVWEQ+SATIVM+
Sbjct: 988 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1047
Query: 176 TNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLV 235
T L+E+ KC QYWP++G TYG I+V + D + L + +R F + +G R V
Sbjct: 1048 TRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK---NGSSEKREV 1104
Query: 236 SQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA 295
Q FT+WPD GVP P L FL++VKT NP AGPIVVHCSAGVGRTG FIVIDAM+
Sbjct: 1105 RQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1164
Query: 296 MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQT 355
+ E+ VDV+ V+ +R+QR MVQT+ QY+FI++ALLE G+TE+ SL ++Q
Sbjct: 1165 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK 1224
Query: 356 MHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMK 415
+ G+E EF++L N + + NLP N K R++ I+PY+ RV L
Sbjct: 1225 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1284
Query: 416 RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ 475
RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+++E +
Sbjct: 1285 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR 1344
Query: 476 DKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFH 535
+KC+QYWP E S + ++ + +R+F VT ++ Q R VRQF F
Sbjct: 1345 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTVRQFQFT 1399
Query: 536 GWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKA 594
WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +LER++
Sbjct: 1400 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1459
Query: 595 EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
EG++D+FQ VK LR QRP MVQT ++Y+FCY+ +++ F YA
Sbjct: 1460 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1504
>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
Length = 1910
Score = 549 bits (1414), Expect = e-156
Identities = 283/585 (48%), Positives = 381/585 (65%), Gaps = 10/585 (1%)
Query: 56 PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115
PIP+ + E A+D + +E+ S+ G Q T+E +N E N+ KNRY N++ DH
Sbjct: 1334 PIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDH 1392
Query: 116 SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175
SRVIL ++GI SDYINA+Y+DGY+ +N +IA QGP ET DFWRMVWEQ+SATIVM+
Sbjct: 1393 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1452
Query: 176 TNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLV 235
T L+E+ KC QYWP++G TYG I+V + D + L + +R F + +G R V
Sbjct: 1453 TRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK---NGSSEKREV 1509
Query: 236 SQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA 295
Q FT+WPD GVP P L FL++VKT NP AGPIVVHCSAGVGRTG FIVIDAM+
Sbjct: 1510 RQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1569
Query: 296 MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQT 355
+ E+ VDV+ V+ +R+QR MVQT+ QY+FI++ALLE G+TE+ SL ++Q
Sbjct: 1570 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK 1629
Query: 356 MHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMK 415
+ G+E EF++L N + + NLP N K R++ I+PY+ RV L
Sbjct: 1630 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1689
Query: 416 RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ 475
RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+++E +
Sbjct: 1690 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR 1749
Query: 476 DKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFH 535
+KC+QYWP E S + ++ + +R+F VT ++ Q R VRQF F
Sbjct: 1750 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTVRQFQFT 1804
Query: 536 GWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKA 594
WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +LER++
Sbjct: 1805 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1864
Query: 595 EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
EG++D+FQ VK LR QRP MVQT ++Y+FCY+ +++ F YA
Sbjct: 1865 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1909
>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
isoform 3 precursor [Homo sapiens]
Length = 1501
Score = 549 bits (1414), Expect = e-156
Identities = 283/585 (48%), Positives = 381/585 (65%), Gaps = 10/585 (1%)
Query: 56 PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115
PIP+ + E A+D + +E+ S+ G Q T+E +N E N+ KNRY N++ DH
Sbjct: 925 PIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDH 983
Query: 116 SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175
SRVIL ++GI SDYINA+Y+DGY+ +N +IA QGP ET DFWRMVWEQ+SATIVM+
Sbjct: 984 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1043
Query: 176 TNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLV 235
T L+E+ KC QYWP++G TYG I+V + D + L + +R F + +G R V
Sbjct: 1044 TRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK---NGSSEKREV 1100
Query: 236 SQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA 295
Q FT+WPD GVP P L FL++VKT NP AGPIVVHCSAGVGRTG FIVIDAM+
Sbjct: 1101 RQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1160
Query: 296 MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQT 355
+ E+ VDV+ V+ +R+QR MVQT+ QY+FI++ALLE G+TE+ SL ++Q
Sbjct: 1161 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK 1220
Query: 356 MHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMK 415
+ G+E EF++L N + + NLP N K R++ I+PY+ RV L
Sbjct: 1221 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1280
Query: 416 RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ 475
RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+++E +
Sbjct: 1281 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR 1340
Query: 476 DKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFH 535
+KC+QYWP E S + ++ + +R+F VT ++ Q R VRQF F
Sbjct: 1341 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTVRQFQFT 1395
Query: 536 GWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKA 594
WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +LER++
Sbjct: 1396 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1455
Query: 595 EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
EG++D+FQ VK LR QRP MVQT ++Y+FCY+ +++ F YA
Sbjct: 1456 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1500
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 549 bits (1414), Expect = e-156
Identities = 283/585 (48%), Positives = 381/585 (65%), Gaps = 10/585 (1%)
Query: 56 PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115
PIP+ + E A+D + +E+ S+ G Q T+E +N E N+ KNRY N++ DH
Sbjct: 1372 PIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDH 1430
Query: 116 SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175
SRVIL ++GI SDYINA+Y+DGY+ +N +IA QGP ET DFWRMVWEQ+SATIVM+
Sbjct: 1431 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1490
Query: 176 TNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLV 235
T L+E+ KC QYWP++G TYG I+V + D + L + +R F + +G R V
Sbjct: 1491 TRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK---NGSSEKREV 1547
Query: 236 SQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA 295
Q FT+WPD GVP P L FL++VKT NP AGPIVVHCSAGVGRTG FIVIDAM+
Sbjct: 1548 RQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1607
Query: 296 MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQT 355
+ E+ VDV+ V+ +R+QR MVQT+ QY+FI++ALLE G+TE+ SL ++Q
Sbjct: 1608 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK 1667
Query: 356 MHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMK 415
+ G+E EF++L N + + NLP N K R++ I+PY+ RV L
Sbjct: 1668 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1727
Query: 416 RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ 475
RG E +DYINASFIDGYRQ+ +IATQGPLA T EDFWRM+WE S +VMLT+++E +
Sbjct: 1728 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR 1787
Query: 476 DKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFH 535
+KC+QYWP E S + ++ + +R+F VT ++ Q R VRQF F
Sbjct: 1788 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTVRQFQFT 1842
Query: 536 GWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKA 594
WPE G+P G+G ID I V K ++Q G + PI+VHCSAG GRTG FI LS +LER++
Sbjct: 1843 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1902
Query: 595 EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639
EG++D+FQ VK LR QRP MVQT ++Y+FCY+ +++ F YA
Sbjct: 1903 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1947
>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
precursor [Homo sapiens]
Length = 1256
Score = 433 bits (1113), Expect = e-121
Identities = 246/603 (40%), Positives = 352/603 (58%), Gaps = 39/603 (6%)
Query: 56 PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115
PI + L E + + AD+ + F EF S+P + + A K N+ KNRY +ILP D+
Sbjct: 582 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 641
Query: 116 SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175
+RV LS+++G S+YINASYIDG+KE K+IAAQGP+ ETV+DFWRM+WEQK+ IVM+
Sbjct: 642 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 701
Query: 176 TNLKERKEEKCHQYWP--DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPR 233
T +E KC +YWP ++G +G++ V + DY I+K I + R
Sbjct: 702 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA--TGR 759
Query: 234 LVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAM 293
V+ + FTSWPD GVP P +LK ++V + +GPIVVHCSAGVGRTGT+I IDAM
Sbjct: 760 EVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAM 819
Query: 294 MAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHL 353
+ + AE KVDV+ +V ++R QR MVQ + QY I+QAL+EY +G+TE+++S L +L
Sbjct: 820 LEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYL 879
Query: 354 QTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILS 413
M + LE EF++L + R + GN N K R +IPYD+NRV L
Sbjct: 880 HNMKKRDPPSEPSPLEAEFQRLPSYRSWR-TQHIGNQEENKSKNRNSNVIPYDYNRVPLK 938
Query: 414 MK-------------------RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWR 454
+ +E + YINASFI Y + + IA QGPL T+ DFW+
Sbjct: 939 HELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQ 998
Query: 455 MIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVT 514
MI++ K IVMLTE++ +Q+ C QYW EG T+G+I +++K+ S ++R F
Sbjct: 999 MIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF--- 1054
Query: 515 LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-----QKQQQQTGNH--- 566
+ + + + R V Q+ + W +PAE K +I +I V QK + H
Sbjct: 1055 --ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKS 1112
Query: 567 -PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCY 625
P+ +HC G+ +TG F AL N+LE + E ++D+FQ VK+LR RP MV T EQY+F Y
Sbjct: 1113 TPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172
Query: 626 KVV 628
V+
Sbjct: 1173 DVI 1175
Score = 173 bits (439), Expect = 4e-43
Identities = 98/264 (37%), Positives = 148/264 (56%), Gaps = 10/264 (3%)
Query: 371 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 430
EF+ + V K ++ P N K R + I+PYD+NRV LS G ++YINAS+ID
Sbjct: 606 EFQSIPRV-FSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID 664
Query: 431 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT--EGSV 488
G+++ +IA QGP TV+DFWRMIWE K+ IVM+T +E ++KC +YWP+ EG+
Sbjct: 665 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR 724
Query: 489 THGEITIEIKNDTLSEAISIRDFLVT-LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 547
G++ ++I D+++ LN +++ R V F WP+ G+P +
Sbjct: 725 AFGDVVVKINQHKRCP-----DYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPH 779
Query: 548 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 607
++ L V PI VHCSAG GRTGT+I + +LE ++AE +DV+ V L
Sbjct: 780 LLLKLRRRVNAFSNFFSG-PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL 838
Query: 608 RLQRPHMVQTLEQYEFCYKVVQDF 631
R QR MVQ QY ++ + ++
Sbjct: 839 RRQRCLMVQVEAQYILIHQALVEY 862
Score = 158 bits (399), Expect = 2e-38
Identities = 100/287 (34%), Positives = 146/287 (50%), Gaps = 33/287 (11%)
Query: 80 EFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL---------SQLDGIPCSD 130
EF LPS T + N+EEN+ KNR N++P D++RV L S+ D SD
Sbjct: 897 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 956
Query: 131 ----------YINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 180
YINAS+I Y + IAAQGP +ET+ DFW+M++++K IVMLT LK
Sbjct: 957 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1016
Query: 181 RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 240
+E C QYW +G TYG+I V ++D YT+R F ++ K R V Q +
Sbjct: 1017 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR---KDSRTVYQYQY 1072
Query: 241 TSWPDFGVPFTPIGMLKFLKKVKTLNPVH----------AGPIVVHCSAGVGRTGTFIVI 290
T+W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132
Query: 291 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY 337
++ E+ VD+F+ V +R RP MV T QY F+Y + Y
Sbjct: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1179
>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
precursor [Homo sapiens]
Length = 1304
Score = 433 bits (1113), Expect = e-121
Identities = 246/603 (40%), Positives = 352/603 (58%), Gaps = 39/603 (6%)
Query: 56 PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115
PI + L E + + AD+ + F EF S+P + + A K N+ KNRY +ILP D+
Sbjct: 630 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 689
Query: 116 SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175
+RV LS+++G S+YINASYIDG+KE K+IAAQGP+ ETV+DFWRM+WEQK+ IVM+
Sbjct: 690 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 749
Query: 176 TNLKERKEEKCHQYWP--DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPR 233
T +E KC +YWP ++G +G++ V + DY I+K I + R
Sbjct: 750 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA--TGR 807
Query: 234 LVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAM 293
V+ + FTSWPD GVP P +LK ++V + +GPIVVHCSAGVGRTGT+I IDAM
Sbjct: 808 EVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAM 867
Query: 294 MAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHL 353
+ + AE KVDV+ +V ++R QR MVQ + QY I+QAL+EY +G+TE+++S L +L
Sbjct: 868 LEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYL 927
Query: 354 QTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILS 413
M + LE EF++L + R + GN N K R +IPYD+NRV L
Sbjct: 928 HNMKKRDPPSEPSPLEAEFQRLPSYRSWR-TQHIGNQEENKSKNRNSNVIPYDYNRVPLK 986
Query: 414 MK-------------------RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWR 454
+ +E + YINASFI Y + + IA QGPL T+ DFW+
Sbjct: 987 HELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQ 1046
Query: 455 MIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVT 514
MI++ K IVMLTE++ +Q+ C QYW EG T+G+I +++K+ S ++R F
Sbjct: 1047 MIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF--- 1102
Query: 515 LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-----QKQQQQTGNH--- 566
+ + + + R V Q+ + W +PAE K +I +I V QK + H
Sbjct: 1103 --ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKS 1160
Query: 567 -PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCY 625
P+ +HC G+ +TG F AL N+LE + E ++D+FQ VK+LR RP MV T EQY+F Y
Sbjct: 1161 TPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220
Query: 626 KVV 628
V+
Sbjct: 1221 DVI 1223
Score = 173 bits (439), Expect = 4e-43
Identities = 98/264 (37%), Positives = 148/264 (56%), Gaps = 10/264 (3%)
Query: 371 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 430
EF+ + V K ++ P N K R + I+PYD+NRV LS G ++YINAS+ID
Sbjct: 654 EFQSIPRV-FSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID 712
Query: 431 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT--EGSV 488
G+++ +IA QGP TV+DFWRMIWE K+ IVM+T +E ++KC +YWP+ EG+
Sbjct: 713 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR 772
Query: 489 THGEITIEIKNDTLSEAISIRDFLVT-LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 547
G++ ++I D+++ LN +++ R V F WP+ G+P +
Sbjct: 773 AFGDVVVKINQHKRCP-----DYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPH 827
Query: 548 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 607
++ L V PI VHCSAG GRTGT+I + +LE ++AE +DV+ V L
Sbjct: 828 LLLKLRRRVNAFSNFFSG-PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL 886
Query: 608 RLQRPHMVQTLEQYEFCYKVVQDF 631
R QR MVQ QY ++ + ++
Sbjct: 887 RRQRCLMVQVEAQYILIHQALVEY 910
Score = 158 bits (399), Expect = 2e-38
Identities = 100/287 (34%), Positives = 146/287 (50%), Gaps = 33/287 (11%)
Query: 80 EFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL---------SQLDGIPCSD 130
EF LPS T + N+EEN+ KNR N++P D++RV L S+ D SD
Sbjct: 945 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 1004
Query: 131 ----------YINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 180
YINAS+I Y + IAAQGP +ET+ DFW+M++++K IVMLT LK
Sbjct: 1005 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 1064
Query: 181 RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 240
+E C QYW +G TYG+I V ++D YT+R F ++ K R V Q +
Sbjct: 1065 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR---KDSRTVYQYQY 1120
Query: 241 TSWPDFGVPFTPIGMLKFLKKVKTLNPVH----------AGPIVVHCSAGVGRTGTFIVI 290
T+W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 1121 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1180
Query: 291 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY 337
++ E+ VD+F+ V +R RP MV T QY F+Y + Y
Sbjct: 1181 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1227
>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
precursor [Homo sapiens]
Length = 1143
Score = 433 bits (1113), Expect = e-121
Identities = 246/603 (40%), Positives = 352/603 (58%), Gaps = 39/603 (6%)
Query: 56 PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115
PI + L E + + AD+ + F EF S+P + + A K N+ KNRY +ILP D+
Sbjct: 469 PIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDY 528
Query: 116 SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175
+RV LS+++G S+YINASYIDG+KE K+IAAQGP+ ETV+DFWRM+WEQK+ IVM+
Sbjct: 529 NRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMV 588
Query: 176 TNLKERKEEKCHQYWP--DQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPR 233
T +E KC +YWP ++G +G++ V + DY I+K I + R
Sbjct: 589 TRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA--TGR 646
Query: 234 LVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAM 293
V+ + FTSWPD GVP P +LK ++V + +GPIVVHCSAGVGRTGT+I IDAM
Sbjct: 647 EVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAM 706
Query: 294 MAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHL 353
+ + AE KVDV+ +V ++R QR MVQ + QY I+QAL+EY +G+TE+++S L +L
Sbjct: 707 LEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYL 766
Query: 354 QTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILS 413
M + LE EF++L + R + GN N K R +IPYD+NRV L
Sbjct: 767 HNMKKRDPPSEPSPLEAEFQRLPSYRSWR-TQHIGNQEENKSKNRNSNVIPYDYNRVPLK 825
Query: 414 MK-------------------RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWR 454
+ +E + YINASFI Y + + IA QGPL T+ DFW+
Sbjct: 826 HELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQ 885
Query: 455 MIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVT 514
MI++ K IVMLTE++ +Q+ C QYW EG T+G+I +++K+ S ++R F
Sbjct: 886 MIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF--- 941
Query: 515 LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAV-----QKQQQQTGNH--- 566
+ + + + R V Q+ + W +PAE K +I +I V QK + H
Sbjct: 942 --ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKS 999
Query: 567 -PITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCY 625
P+ +HC G+ +TG F AL N+LE + E ++D+FQ VK+LR RP MV T EQY+F Y
Sbjct: 1000 TPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059
Query: 626 KVV 628
V+
Sbjct: 1060 DVI 1062
Score = 173 bits (439), Expect = 4e-43
Identities = 98/264 (37%), Positives = 148/264 (56%), Gaps = 10/264 (3%)
Query: 371 EFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFID 430
EF+ + V K ++ P N K R + I+PYD+NRV LS G ++YINAS+ID
Sbjct: 493 EFQSIPRV-FSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYID 551
Query: 431 GYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPT--EGSV 488
G+++ +IA QGP TV+DFWRMIWE K+ IVM+T +E ++KC +YWP+ EG+
Sbjct: 552 GFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTR 611
Query: 489 THGEITIEIKNDTLSEAISIRDFLVT-LNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 547
G++ ++I D+++ LN +++ R V F WP+ G+P +
Sbjct: 612 AFGDVVVKINQHKRCP-----DYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPH 666
Query: 548 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 607
++ L V PI VHCSAG GRTGT+I + +LE ++AE +DV+ V L
Sbjct: 667 LLLKLRRRVNAFSNFFSG-PIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKL 725
Query: 608 RLQRPHMVQTLEQYEFCYKVVQDF 631
R QR MVQ QY ++ + ++
Sbjct: 726 RRQRCLMVQVEAQYILIHQALVEY 749
Score = 158 bits (399), Expect = 2e-38
Identities = 100/287 (34%), Positives = 146/287 (50%), Gaps = 33/287 (11%)
Query: 80 EFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVIL---------SQLDGIPCSD 130
EF LPS T + N+EEN+ KNR N++P D++RV L S+ D SD
Sbjct: 784 EFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSD 843
Query: 131 ----------YINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKE 180
YINAS+I Y + IAAQGP +ET+ DFW+M++++K IVMLT LK
Sbjct: 844 DDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKH 903
Query: 181 RKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHF 240
+E C QYW +G TYG+I V ++D YT+R F ++ K R V Q +
Sbjct: 904 GDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKR---KDSRTVYQYQY 959
Query: 241 TSWPDFGVPFTPIGMLKFLKKVKTLNPVH----------AGPIVVHCSAGVGRTGTFIVI 290
T+W +P P ++ ++ VK P + P+++HC G +TG F +
Sbjct: 960 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019
Query: 291 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYY 337
++ E+ VD+F+ V +R RP MV T QY F+Y + Y
Sbjct: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTY 1066
>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
[Homo sapiens]
Length = 1440
Score = 426 bits (1096), Expect = e-119
Identities = 238/583 (40%), Positives = 346/583 (59%), Gaps = 18/583 (3%)
Query: 57 IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHS 116
I V L + I + D F+EE+ S G ++++A K++NR KNRY NI+ DHS
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHS 926
Query: 117 RVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLT 176
RVIL ++ P SDYINA+YIDGY+ + +IA QGP ETV DFWRM+W+++SA IVM+T
Sbjct: 927 RVILQPVEDDPSSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVT 986
Query: 177 NLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVS 236
NL E KC++YWPD YG+ +V + L +Y +R F ++ + G R V
Sbjct: 987 NLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERR---GYNEIREVK 1042
Query: 237 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAM 296
Q HFT WPD GVP+ G+L F+++VK NP AGPIVVHCSAG GRTG +IVID M+ M
Sbjct: 1043 QFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDM 1102
Query: 297 MHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTM 356
E VD++ V +R++R MVQT+ QY FI+ A+LE L G+T + V + M
Sbjct: 1103 AEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDM 1162
Query: 357 HGTTTHFDKIGLEEEFRKLTNV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSM 414
+ + L++EF+ L +V R+ E+ LP N K R + ++P D L
Sbjct: 1163 IRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLIT 1222
Query: 415 KRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQERE 474
G E ++YINA+ +D YRQ FI TQ PL +TV+DFWR+++++ +IVML EV +
Sbjct: 1223 IDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQ 1281
Query: 475 QDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDF-LVTLNQPQARQEEQVRVVRQFH 533
C QYWP EG + +G I +E + ++ + R F + L +PQ E +V+QF
Sbjct: 1282 --GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ----EGYLMVQQFQ 1335
Query: 534 FHGW-PEIGIPAEGKGMIDLIAAVQKQQQ--QTGNHPITVHCSAGAGRTGTFIALSNILE 590
+ GW +P + + LI V+K Q+ + G +HC G GR+G F A+ ++E
Sbjct: 1336 YLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVE 1395
Query: 591 RVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID 633
VK + ++DVF AVK+LR +P+MV+ EQY FCY V ++++
Sbjct: 1396 MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1438
>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
precursor [Homo sapiens]
Length = 1452
Score = 423 bits (1087), Expect = e-118
Identities = 235/562 (41%), Positives = 333/562 (59%), Gaps = 16/562 (2%)
Query: 77 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136
F+EE+ S G ++ A K+ENR KNRY NI+ DHSRV L ++G SDYIN +Y
Sbjct: 900 FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNY 958
Query: 137 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 196
IDGY N +IA QGP QET+ DFWRMVW + +A+I+M+TNL E KC +YWPD
Sbjct: 959 IDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TE 1017
Query: 197 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 256
Y +I+V + + +L +Y IR F ++ + G R + Q HFT WPD GVP+ G+L
Sbjct: 1018 IYKDIKVTLIETELLAEYVIRTFAVEKR---GVHEIREIRQFHFTGWPDHGVPYHATGLL 1074
Query: 257 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 316
F+++VK+ +P AGP+VVHCSAG GRTG FIVID M+ M E VD++ V +R++R
Sbjct: 1075 GFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR 1134
Query: 317 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 376
MVQT+ QY FI+ A+LE L GDT + S + M+ + ++EEFR L
Sbjct: 1135 VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1194
Query: 377 NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 434
V + E+ LP N +K R + I+P D L G E ++YINA+ +D Y+Q
Sbjct: 1195 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1253
Query: 435 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 494
FI TQ PL +TV+DFWR++ ++ ++VML +V + C QYWP G HG I
Sbjct: 1254 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQ 1311
Query: 495 IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 553
+E + L E I R F + AR ++ R+V+QF F GWP P + + LI
Sbjct: 1312 VEFVSADLEEDIISRIFRI---YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLI 1368
Query: 554 AAVQKQQQQ--TGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 611
V K Q++ G VHC G GR+GTF A+S + E ++ + +DVF AVK+LR +
Sbjct: 1369 RQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNK 1428
Query: 612 PHMVQTLEQYEFCYKVVQDFID 633
P+MV L+QY+FCY+V ++++
Sbjct: 1429 PNMVDLLDQYKFCYEVALEYLN 1450
>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
precursor [Homo sapiens]
Length = 1465
Score = 423 bits (1087), Expect = e-118
Identities = 235/562 (41%), Positives = 333/562 (59%), Gaps = 16/562 (2%)
Query: 77 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136
F+EE+ S G ++ A K+ENR KNRY NI+ DHSRV L ++G SDYIN +Y
Sbjct: 913 FKEEYESFFEGQ-SAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNY 971
Query: 137 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 196
IDGY N +IA QGP QET+ DFWRMVW + +A+I+M+TNL E KC +YWPD
Sbjct: 972 IDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDD-TE 1030
Query: 197 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 256
Y +I+V + + +L +Y IR F ++ + G R + Q HFT WPD GVP+ G+L
Sbjct: 1031 IYKDIKVTLIETELLAEYVIRTFAVEKR---GVHEIREIRQFHFTGWPDHGVPYHATGLL 1087
Query: 257 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 316
F+++VK+ +P AGP+VVHCSAG GRTG FIVID M+ M E VD++ V +R++R
Sbjct: 1088 GFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRR 1147
Query: 317 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 376
MVQT+ QY FI+ A+LE L GDT + S + M+ + ++EEFR L
Sbjct: 1148 VNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLN 1207
Query: 377 NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 434
V + E+ LP N +K R + I+P D L G E ++YINA+ +D Y+Q
Sbjct: 1208 MVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQ 1266
Query: 435 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 494
FI TQ PL +TV+DFWR++ ++ ++VML +V + C QYWP G HG I
Sbjct: 1267 PSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQ--LCPQYWPENGVHRHGPIQ 1324
Query: 495 IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 553
+E + L E I R F + AR ++ R+V+QF F GWP P + + LI
Sbjct: 1325 VEFVSADLEEDIISRIFRI---YNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLI 1381
Query: 554 AAVQKQQQQ--TGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 611
V K Q++ G VHC G GR+GTF A+S + E ++ + +DVF AVK+LR +
Sbjct: 1382 RQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNK 1441
Query: 612 PHMVQTLEQYEFCYKVVQDFID 633
P+MV L+QY+FCY+V ++++
Sbjct: 1442 PNMVDLLDQYKFCYEVALEYLN 1463
>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
precursor [Homo sapiens]
Length = 1441
Score = 421 bits (1082), Expect = e-117
Identities = 230/564 (40%), Positives = 334/564 (59%), Gaps = 16/564 (2%)
Query: 77 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136
F+EE+ +LP G +++ A ++ENR KNRY NI+ DHSRV L LDG P SDYINA+Y
Sbjct: 889 FKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 947
Query: 137 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 196
IDGY +IA QGP QETV DFWRM+W++ SA+IVM+TNL E KC +YWPD
Sbjct: 948 IDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TE 1006
Query: 197 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 256
YG+I+V + + L +Y IR F +Q + G R + HFTSWPD GVP G+L
Sbjct: 1007 VYGDIKVTLIETEPLAEYVIRTFTVQKK---GYHEIRELRLFHFTSWPDHGVPCYATGLL 1063
Query: 257 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 316
F+++VK LNP AGPIVVHCSAG GRTG FI ID M+ M E VD+F V +R QR
Sbjct: 1064 GFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQR 1123
Query: 317 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 376
+VQT+ QY F++ A+LE L G+T + V + + +++EF+ L
Sbjct: 1124 VNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLN 1183
Query: 377 NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 434
V R+ E+ G LP N K R + ++P D L G E ++YINA+ +D ++Q
Sbjct: 1184 IVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQ 1242
Query: 435 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 494
F+ TQ PL +TV DFWR+++++ ++VML E+ + C QYWP + S +G I
Sbjct: 1243 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEKTSGCYGPIQ 1300
Query: 495 IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 553
+E + + E I R F + AR ++ R+V+ + GWP P + ++ ++
Sbjct: 1301 VEFVSADIDEDIIHRIFRIC---NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVV 1357
Query: 554 AAVQKQQQQTGNHP--ITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 611
++K Q+Q VHC G GR+GTF A+ ++ E ++ + ++DVF VK+LR +
Sbjct: 1358 RRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNK 1417
Query: 612 PHMVQTLEQYEFCYKVVQDFIDIF 635
+MV+TLEQY+F Y+V +++ F
Sbjct: 1418 SNMVETLEQYKFVYEVALEYLSSF 1441
>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
precursor [Homo sapiens]
Length = 1460
Score = 421 bits (1082), Expect = e-117
Identities = 230/564 (40%), Positives = 334/564 (59%), Gaps = 16/564 (2%)
Query: 77 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136
F+EE+ +LP G +++ A ++ENR KNRY NI+ DHSRV L LDG P SDYINA+Y
Sbjct: 908 FKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANY 966
Query: 137 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 196
IDGY +IA QGP QETV DFWRM+W++ SA+IVM+TNL E KC +YWPD
Sbjct: 967 IDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TE 1025
Query: 197 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 256
YG+I+V + + L +Y IR F +Q + G R + HFTSWPD GVP G+L
Sbjct: 1026 VYGDIKVTLIETEPLAEYVIRTFTVQKK---GYHEIRELRLFHFTSWPDHGVPCYATGLL 1082
Query: 257 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 316
F+++VK LNP AGPIVVHCSAG GRTG FI ID M+ M E VD+F V +R QR
Sbjct: 1083 GFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQR 1142
Query: 317 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 376
+VQT+ QY F++ A+LE L G+T + V + + +++EF+ L
Sbjct: 1143 VNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLN 1202
Query: 377 NV--RIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 434
V R+ E+ G LP N K R + ++P D L G E ++YINA+ +D ++Q
Sbjct: 1203 IVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQ 1261
Query: 435 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEIT 494
F+ TQ PL +TV DFWR+++++ ++VML E+ + C QYWP + S +G I
Sbjct: 1262 PAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEKTSGCYGPIQ 1319
Query: 495 IEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDLI 553
+E + + E I R F + AR ++ R+V+ + GWP P + ++ ++
Sbjct: 1320 VEFVSADIDEDIIHRIFRIC---NMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVV 1376
Query: 554 AAVQKQQQQTGNHP--ITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQR 611
++K Q+Q VHC G GR+GTF A+ ++ E ++ + ++DVF VK+LR +
Sbjct: 1377 RRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNK 1436
Query: 612 PHMVQTLEQYEFCYKVVQDFIDIF 635
+MV+TLEQY+F Y+V +++ F
Sbjct: 1437 SNMVETLEQYKFVYEVALEYLSSF 1460
>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
[Homo sapiens]
Length = 1446
Score = 420 bits (1079), Expect = e-117
Identities = 238/589 (40%), Positives = 346/589 (58%), Gaps = 24/589 (4%)
Query: 57 IPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHS 116
I V L + I + D F+EE+ S G ++++A K++NR KNRY NI+ DHS
Sbjct: 868 IRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHS 926
Query: 117 RVILSQLDGIPCSDYINASYID------GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSA 170
RVIL ++ P SDYINA+YID GY+ + +IA QGP ETV DFWRM+W+++SA
Sbjct: 927 RVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSA 986
Query: 171 TIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCK 230
IVM+TNL E KC++YWPD YG+ +V + L +Y +R F ++ + G
Sbjct: 987 CIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERR---GYN 1042
Query: 231 APRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVI 290
R V Q HFT WPD GVP+ G+L F+++VK NP AGPIVVHCSAG GRTG +IVI
Sbjct: 1043 EIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVI 1102
Query: 291 DAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLE 350
D M+ M E VD++ V +R++R MVQT+ QY FI+ A+LE L G+T + V +
Sbjct: 1103 DIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFK 1162
Query: 351 KHLQTMHGTTTHFDKIGLEEEFRKLTNV--RIMKENMRTGNLPANMKKARVIQIIPYDFN 408
M + + L++EF+ L +V R+ E+ LP N K R + ++P D
Sbjct: 1163 AAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRC 1222
Query: 409 RVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLT 468
L G E ++YINA+ +D YRQ FI TQ PL +TV+DFWR+++++ +IVML
Sbjct: 1223 LPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLN 1281
Query: 469 EVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDF-LVTLNQPQARQEEQVR 527
EV + C QYWP EG + +G I +E + ++ + R F + L +PQ E
Sbjct: 1282 EVDLSQ--GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ----EGYL 1335
Query: 528 VVRQFHFHGW-PEIGIPAEGKGMIDLIAAVQKQQQ--QTGNHPITVHCSAGAGRTGTFIA 584
+V+QF + GW +P + + LI V+K Q+ + G +HC G GR+G F A
Sbjct: 1336 MVQQFQYLGWASHREVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCA 1395
Query: 585 LSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFID 633
+ ++E VK + ++DVF AVK+LR +P+MV+ EQY FCY V ++++
Sbjct: 1396 IGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE 1444
>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
precursor [Homo sapiens]
Length = 2315
Score = 378 bits (971), Expect = e-105
Identities = 232/625 (37%), Positives = 342/625 (54%), Gaps = 39/625 (6%)
Query: 33 LEEQEQQRVMLLSRSPSGP--KKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGH-- 88
LE+ RV+ +P P IP++H + + A F EEF +L +
Sbjct: 1673 LEDSTSPRVISTPPTPIFPISDDVGAIPIKHFPKHVADLHASS--GFTEEFETLKEFYQE 1730
Query: 89 IQG-------TFELANKEENREKNRYPNILPNDHSRVILSQL---DGIPCSDYINASYID 138
+Q T + +N +N+ KNRY NI+ DHSRV L+QL DG +DYINA+Y+D
Sbjct: 1731 VQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDG-KLTDYINANYVD 1789
Query: 139 GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTY 198
GY +IAAQGP + T DFWRM+WE IVM+TNL E+ KC QYWP G Y
Sbjct: 1790 GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEY 1849
Query: 199 GNIRVCVEDCVVLVDYTIRKFC-----IQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPI 253
GN V + VL YT+R F I+ G + R+V+Q H+T WPD GVP +
Sbjct: 1850 GNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSL 1909
Query: 254 GMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIR 313
+L F++K GP+VVHCSAGVGRTGT+IV+D+M+ + E V++F F+ IR
Sbjct: 1910 PVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIR 1969
Query: 314 NQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFR 373
+QR +VQT+ QY FI+ L+E L +TE+ S + ++ + K LE++F+
Sbjct: 1970 SQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALL-IPGPAGKTKLEKQFQ 2028
Query: 374 KLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYR 433
L+ I + + N +K R IIP + +RV +S G E TDYINAS+I GY
Sbjct: 2029 LLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYY 2087
Query: 434 QKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGE- 492
Q + FI TQ PL HT++DFWRMIW+ + +VM+ + Q +D+ + YWP + + E
Sbjct: 2088 QSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKDEPINCES 2146
Query: 493 --ITI---EIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGK 547
+T+ E K + E + I+DF++ +A Q++ V VR F WP P
Sbjct: 2147 FKVTLMAEEHKCLSNEEKLIIQDFIL-----EATQDDYVLEVRHFQCPKWPNPDSPI--S 2199
Query: 548 GMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSL 607
+LI+ + K++ + P+ VH G GTF AL+ ++ +++ E +DV+Q K +
Sbjct: 2200 KTFELISVI-KEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMI 2258
Query: 608 RLQRPHMVQTLEQYEFCYKVVQDFI 632
L RP + +EQY+F YKV+ +
Sbjct: 2259 NLMRPGVFADIEQYQFLYKVILSLV 2283
Score = 125 bits (314), Expect = 1e-28
Identities = 86/285 (30%), Positives = 142/285 (49%), Gaps = 16/285 (5%)
Query: 76 QFREEFNSLPSGHIQGT-FELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINA 134
+ ++F L +IQ + + A K+ NREKNR +I+P + SRV +S L G +DYINA
Sbjct: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080
Query: 135 SYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQ- 193
SYI GY + N+FI Q P T+ DFWRM+W+ + +VM+ + + E++ YWP++
Sbjct: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FVYWPNKD 2139
Query: 194 ---GCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFT--SWPDFGV 248
C ++ + + E+ L + K IQ + + + ++ HF WP+
Sbjct: 2140 EPINCESF-KVTLMAEEHKCLSNE--EKLIIQDFILEATQDDYVLEVRHFQCPKWPN--- 2193
Query: 249 PFTPIGM-LKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFE 307
P +PI + + +K GP++VH G GTF + +M + E VDV++
Sbjct: 2194 PDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQ 2253
Query: 308 FVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKH 352
I RP + QY F+Y+ +L E +SL+ +
Sbjct: 2254 VAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSN 2298
>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
precursor [Homo sapiens]
Length = 1436
Score = 377 bits (967), Expect = e-104
Identities = 212/561 (37%), Positives = 313/561 (55%), Gaps = 17/561 (3%)
Query: 77 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136
F++E+ S G ++ K++ + +R + D RV L + G P +DYINA+Y
Sbjct: 884 FKQEYESFFEG-----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANY 938
Query: 137 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 196
IDGY N FIA QGPK E V DFWRMVW++ ++IVM+T L E KC +YWP+
Sbjct: 939 IDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD- 997
Query: 197 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 256
TYG+I++ + L +Y +R F ++ + G A V Q HFT+WP+ GVP+ G+L
Sbjct: 998 TYGDIKIMLVKTETLAEYVVRTFALERR---GYSARHEVRQFHFTAWPEHGVPYHATGLL 1054
Query: 257 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 316
F+++VK P AGPIV+HCSAG GRTG +IV+D M+ M E VD++ V + ++R
Sbjct: 1055 AFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRR 1114
Query: 317 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 376
M+QT+ QY FI+ A+LE L G+T + VS + + M + L EEF+ L
Sbjct: 1115 VNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLN 1174
Query: 377 NVR--IMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 434
+V + E LP N K R + ++P D L G + +YINA+ D Y +
Sbjct: 1175 SVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTR 1233
Query: 435 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEV-QEREQDKCYQYWPTEGSVTHGEI 493
FI T PL T DFWR+++++ +IVML ++ Q C QYWP G +G +
Sbjct: 1234 SAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLM 1293
Query: 494 TIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDL 552
+E + T E + R F V Q +R +E +VR F F W P K + L
Sbjct: 1294 EVEFMSGTADEDLVARVFRV---QNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHL 1350
Query: 553 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 612
+A V K Q ++G+ VHC G GR+GTF A + +LE ++ L+DVF A K+LR +P
Sbjct: 1351 LAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKP 1410
Query: 613 HMVQTLEQYEFCYKVVQDFID 633
+MV+T++QY FCY V ++++
Sbjct: 1411 NMVETMDQYHFCYDVALEYLE 1431
Score = 131 bits (329), Expect = 2e-30
Identities = 96/284 (33%), Positives = 131/284 (46%), Gaps = 16/284 (5%)
Query: 63 EEEIRIRSADDCKQFREEFNSLPSGHIQGTFE---LANKEENREKNRYPNILPNDHSRVI 119
+E IRI + Q REEF +L S E +A NR+KNR ++LP D
Sbjct: 1152 KEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPF 1211
Query: 120 LSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLK 179
L DG ++YINA+ D Y FI P Q T DFWR+V++ +IVML L
Sbjct: 1212 LISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1270
Query: 180 ERKEE-KCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ--PQLPDGCKAPRLVS 236
+ C QYWP+ G YG + V D R F +Q +L +G R
Sbjct: 1271 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1330
Query: 237 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA----GPIVVHCSAGVGRTGTFIVIDA 292
L ++++ D TP FL + ++ A G +VHC G GR+GTF
Sbjct: 1331 FLRWSAYRD-----TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1385
Query: 293 MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 336
++ M+ VDVF +RN +P MV+T QY F Y LEY
Sbjct: 1386 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1429
>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
precursor [Homo sapiens]
Length = 1446
Score = 377 bits (967), Expect = e-104
Identities = 212/561 (37%), Positives = 313/561 (55%), Gaps = 17/561 (3%)
Query: 77 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136
F++E+ S G ++ K++ + +R + D RV L + G P +DYINA+Y
Sbjct: 894 FKQEYESFFEG-----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANY 948
Query: 137 IDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCW 196
IDGY N FIA QGPK E V DFWRMVW++ ++IVM+T L E KC +YWP+
Sbjct: 949 IDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYWPEDSD- 1007
Query: 197 TYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGML 256
TYG+I++ + L +Y +R F ++ + G A V Q HFT+WP+ GVP+ G+L
Sbjct: 1008 TYGDIKIMLVKTETLAEYVVRTFALERR---GYSARHEVRQFHFTAWPEHGVPYHATGLL 1064
Query: 257 KFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQR 316
F+++VK P AGPIV+HCSAG GRTG +IV+D M+ M E VD++ V + ++R
Sbjct: 1065 AFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLCSRR 1124
Query: 317 PQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLT 376
M+QT+ QY FI+ A+LE L G+T + VS + + M + L EEF+ L
Sbjct: 1125 VNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQTLN 1184
Query: 377 NVR--IMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQ 434
+V + E LP N K R + ++P D L G + +YINA+ D Y +
Sbjct: 1185 SVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAALTDSYTR 1243
Query: 435 KDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEV-QEREQDKCYQYWPTEGSVTHGEI 493
FI T PL T DFWR+++++ +IVML ++ Q C QYWP G +G +
Sbjct: 1244 SAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQQYGLM 1303
Query: 494 TIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEGKGMIDL 552
+E + T E + R F V Q +R +E +VR F F W P K + L
Sbjct: 1304 EVEFMSGTADEDLVARVFRV---QNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFLHL 1360
Query: 553 IAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRP 612
+A V K Q ++G+ VHC G GR+GTF A + +LE ++ L+DVF A K+LR +P
Sbjct: 1361 LAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRNYKP 1420
Query: 613 HMVQTLEQYEFCYKVVQDFID 633
+MV+T++QY FCY V ++++
Sbjct: 1421 NMVETMDQYHFCYDVALEYLE 1441
Score = 131 bits (329), Expect = 2e-30
Identities = 96/284 (33%), Positives = 131/284 (46%), Gaps = 16/284 (5%)
Query: 63 EEEIRIRSADDCKQFREEFNSLPSGHIQGTFE---LANKEENREKNRYPNILPNDHSRVI 119
+E IRI + Q REEF +L S E +A NR+KNR ++LP D
Sbjct: 1162 KEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPF 1221
Query: 120 LSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLK 179
L DG ++YINA+ D Y FI P Q T DFWR+V++ +IVML L
Sbjct: 1222 LISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1280
Query: 180 ERKEE-KCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ--PQLPDGCKAPRLVS 236
+ C QYWP+ G YG + V D R F +Q +L +G R
Sbjct: 1281 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1340
Query: 237 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA----GPIVVHCSAGVGRTGTFIVIDA 292
L ++++ D TP FL + ++ A G +VHC G GR+GTF
Sbjct: 1341 FLRWSAYRD-----TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1395
Query: 293 MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 336
++ M+ VDVF +RN +P MV+T QY F Y LEY
Sbjct: 1396 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1439
>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
[Homo sapiens]
Length = 1445
Score = 374 bits (959), Expect = e-103
Identities = 225/594 (37%), Positives = 325/594 (54%), Gaps = 28/594 (4%)
Query: 57 IPVEHLEEEIRIRSADDCKQFREEFNSLP--SGHIQGTFELANKEENREKNRYPNILPND 114
IPV+ + I +++ F E+F + + + T E +N EN+ KNRY NIL D
Sbjct: 828 IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYD 887
Query: 115 HSRVILSQLDGIPC--SDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATI 172
HSRV L L G SDYINA+Y+DGY + +IA QGP + T DFWRM+WEQ + I
Sbjct: 888 HSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII 947
Query: 173 VMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCI--------QPQ 224
VM+TNL E+ KC QYWP + YGNI V ++ + YT+R+F I Q
Sbjct: 948 VMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKG 1007
Query: 225 LPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRT 284
P G + R+V Q H+T WPD GVP + +L F+++ GP++VHCSAGVGRT
Sbjct: 1008 NPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRT 1067
Query: 285 GTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTEL 344
GT+IVID+M+ + + V+V F+ IR QR +VQT+ QY FI+ ALLE L +TE+
Sbjct: 1068 GTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV 1127
Query: 345 DVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIP 404
+ L ++ ++ K LE++F+ +T + N +K R ++P
Sbjct: 1128 SSNQLHSYVNSILIPGVG-GKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVP 1186
Query: 405 YDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTI 464
+ RV L+ G + TDYINAS+I GY + + FI TQ PL HT +DFWRMIW+ + I
Sbjct: 1187 SERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII 1246
Query: 465 VMLTEVQEREQDKCYQYWPT-EGSVTHGEITIE-IKNDTL----SEAISIRDFLVTLNQP 518
VML + Q +D+ + YWP+ E S+ T+ I D L E I I DF++
Sbjct: 1247 VMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFIL----- 1300
Query: 519 QARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGR 578
+A Q++ V VR F WP P +LI + K++ T + P VH GA
Sbjct: 1301 EATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVI-KEEALTRDGPTIVHDEYGAVS 1357
Query: 579 TGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFI 632
G AL+ + ++++ E +DVFQ K + L RP + +EQY+F YK + +
Sbjct: 1358 AGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV 1411
>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
precursor [Homo sapiens]
Length = 1442
Score = 370 bits (950), Expect = e-102
Identities = 212/567 (37%), Positives = 313/567 (55%), Gaps = 23/567 (4%)
Query: 77 FREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASY 136
F++E+ S G ++ K++ + +R + D RV L + G P +DYINA+Y
Sbjct: 884 FKQEYESFFEG-----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNADYINANY 938
Query: 137 ID------GYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYW 190
ID GY N FIA QGPK E V DFWRMVW++ ++IVM+T L E KC +YW
Sbjct: 939 IDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYW 998
Query: 191 PDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPF 250
P+ TYG+I++ + L +Y +R F ++ + G A V Q HFT+WP+ GVP+
Sbjct: 999 PEDSD-TYGDIKIMLVKTETLAEYVVRTFALERR---GYSARHEVRQFHFTAWPEHGVPY 1054
Query: 251 TPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVS 310
G+L F+++VK P AGPIV+HCSAG GRTG +IV+D M+ M E VD++ V
Sbjct: 1055 HATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVK 1114
Query: 311 RIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEE 370
+ ++R M+QT+ QY FI+ A+LE L G+T + VS + + M + L E
Sbjct: 1115 TLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLRE 1174
Query: 371 EFRKLTNVR--IMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASF 428
EF+ L +V + E LP N K R + ++P D L G + +YINA+
Sbjct: 1175 EFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPFLISTDG-DSNNYINAAL 1233
Query: 429 IDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEV-QEREQDKCYQYWPTEGS 487
D Y + FI T PL T DFWR+++++ +IVML ++ Q C QYWP G
Sbjct: 1234 TDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGR 1293
Query: 488 VTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEI-GIPAEG 546
+G + +E + T E + R F V Q +R +E +VR F F W P
Sbjct: 1294 QQYGLMEVEFMSGTADEDLVARVFRV---QNISRLQEGHLLVRHFQFLRWSAYRDTPDSK 1350
Query: 547 KGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKS 606
K + L+A V K Q ++G+ VHC G GR+GTF A + +LE ++ L+DVF A K+
Sbjct: 1351 KAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKT 1410
Query: 607 LRLQRPHMVQTLEQYEFCYKVVQDFID 633
LR +P+MV+T++QY FCY V ++++
Sbjct: 1411 LRNYKPNMVETMDQYHFCYDVALEYLE 1437
Score = 131 bits (329), Expect = 2e-30
Identities = 96/284 (33%), Positives = 131/284 (46%), Gaps = 16/284 (5%)
Query: 63 EEEIRIRSADDCKQFREEFNSLPSGHIQGTFE---LANKEENREKNRYPNILPNDHSRVI 119
+E IRI + Q REEF +L S E +A NR+KNR ++LP D
Sbjct: 1158 KEMIRIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDRCLPF 1217
Query: 120 LSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLK 179
L DG ++YINA+ D Y FI P Q T DFWR+V++ +IVML L
Sbjct: 1218 LISTDG-DSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLN 1276
Query: 180 ERKEE-KCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQ--PQLPDGCKAPRLVS 236
+ C QYWP+ G YG + V D R F +Q +L +G R
Sbjct: 1277 QSNSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQ 1336
Query: 237 QLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHA----GPIVVHCSAGVGRTGTFIVIDA 292
L ++++ D TP FL + ++ A G +VHC G GR+GTF
Sbjct: 1337 FLRWSAYRD-----TPDSKKAFLHLLAEVDKWQAESGDGRTIVHCLNGGGRSGTFCACAT 1391
Query: 293 MMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEY 336
++ M+ VDVF +RN +P MV+T QY F Y LEY
Sbjct: 1392 VLEMIRCHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEY 1435
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.414
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,141,320
Number of Sequences: 37866
Number of extensions: 1101181
Number of successful extensions: 3567
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 111
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 2629
Number of HSP's gapped (non-prelim): 253
length of query: 642
length of database: 18,247,518
effective HSP length: 109
effective length of query: 533
effective length of database: 14,120,124
effective search space: 7526026092
effective search space used: 7526026092
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.