Search of human proteins with 187960086

Search of human proteins with 187960086

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|187960086 cytochrome P450, family 4, subfamily v,
polypeptide 2 [Homo sapiens]
         (525 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide...  1073   0.0  
gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide ...   293   3e-79
gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8...   288   6e-78
gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide...   280   2e-75
gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11...   280   2e-75
gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11...   280   2e-75
gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide...   278   1e-74
gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide ...   276   3e-74
gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide...   275   7e-74
gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide...   252   7e-67
gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide...   248   7e-66
gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide...   247   2e-65
gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide ...   234   2e-61
gi|30023836 cytochrome P450 4Z1 [Homo sapiens]                        230   2e-60
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...   170   3e-42
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...   168   1e-41
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ...   162   7e-40
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...   158   1e-38
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ...   157   2e-38
gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [H...   143   3e-34
gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [H...   143   3e-34
gi|5729796 cytochrome P450, family 46 [Homo sapiens]                  142   6e-34
gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide ...   132   1e-30
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   130   3e-30
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   127   2e-29
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   124   2e-28
gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide...   122   6e-28
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   120   3e-27
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   120   3e-27
gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide ...   120   4e-27

>gi|187960086 cytochrome P450, family 4, subfamily v, polypeptide 2
           [Homo sapiens]
          Length = 525

 Score = 1073 bits (2775), Expect = 0.0
 Identities = 525/525 (100%), Positives = 525/525 (100%)

Query: 1   MAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLV 60
           MAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLV
Sbjct: 1   MAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLV 60

Query: 61  GHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDK 120
           GHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDK
Sbjct: 61  GHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDK 120

Query: 121 SSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKH 180
           SSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKH
Sbjct: 121 SSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKH 180

Query: 181 INQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLW 240
           INQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLW
Sbjct: 181 INQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLW 240

Query: 241 LDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFL 300
           LDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFL
Sbjct: 241 LDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFL 300

Query: 301 DLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELD 360
           DLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELD
Sbjct: 301 DLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELD 360

Query: 361 DVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAV 420
           DVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAV
Sbjct: 361 DVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAV 420

Query: 421 IIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTI 480
           IIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTI
Sbjct: 421 IIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTI 480

Query: 481 LSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADER 525
           LSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADER
Sbjct: 481 LSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADER 525


>gi|13435391 cytochrome P450, family 4, subfamily F, polypeptide 2
           [Homo sapiens]
          Length = 520

 Score =  293 bits (750), Expect = 3e-79
 Identities = 184/529 (34%), Positives = 296/529 (55%), Gaps = 31/529 (5%)

Query: 6   LGLVWQKLLLWGAASA----LSLAGASLVLS-LLQRVASYARKWQQMRPIPTVARAYPLV 60
           L L W  L LW  A++    L L GAS +L+ +L    ++    +++R  P   R     
Sbjct: 4   LSLSW--LGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFW 61

Query: 61  GHALLMKP--DGREFFQQIIE-YTEEYRHMPLLKLWVGPV-PMVALYNAENVEVILTSSK 116
           GH  ++ P  +G     Q++  Y + +      K+W+GP+ P+++L + + +  ++ +S 
Sbjct: 62  GHQGMVNPTEEGMRVLTQLVATYPQGF------KVWMGPISPLLSLCHPDIIRSVINASA 115

Query: 117 QIDKSS--MYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILV 174
            I       Y FLEPWLG GLL S G+KW   R+MLTP FHF IL+ ++ I NE  NI+ 
Sbjct: 116 AIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMH 175

Query: 175 KKLEKHINQEA--FNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFR 232
            K +   ++ +   + F +I+L  LD + +     +   Q    SEY+ A+  +S ++ +
Sbjct: 176 AKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKP-SEYIAAILELSALVSK 234

Query: 233 RIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPS 292
           R     L +D  Y +  +G   +++ +++H FT++VI ER   + +      D    A +
Sbjct: 235 RHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGV---DDFLQAKA 291

Query: 293 KNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQ 352
           K+K   F+D+LL   D++G +LS EDIR E DTFMFEGHDTTA+ ++W LY L  +PE Q
Sbjct: 292 KSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQ 351

Query: 353 KKVDHELDDVFGKSDRPATVE--DLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAG 410
           ++   E+ ++  K   P  +E  DL  L +L   +KE+LRL P VP+ +R V++D  +  
Sbjct: 352 ERCRQEVQELL-KDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPD 410

Query: 411 YRVL-KGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIG 469
            RV+ KG   +I  +  H +P  +P+PE + P RF PEN + R P A++PFSAGPRNCIG
Sbjct: 411 GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIG 470

Query: 470 QKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLK 518
           Q FA+ E K +L+  L  F +  +    E   + +L+LR   G+W++++
Sbjct: 471 QTFAMAEMKVVLALTLLRFRVLPD--HTEPRRKPELVLRAEGGLWLRVE 517


>gi|6005737 cytochrome P450, family 4, subfamily F, polypeptide 8
           [Homo sapiens]
          Length = 520

 Score =  288 bits (738), Expect = 6e-78
 Identities = 183/527 (34%), Positives = 289/527 (54%), Gaps = 30/527 (5%)

Query: 5   WLGLVWQKLLLWGAASALSLAGASLVLS-LLQRVASYARKWQQMRPIPTVARAYPLVGHA 63
           WLGL       W     L + GAS +L+ +L    ++    +++R  P   +    +GH 
Sbjct: 8   WLGLRPVAASPW---LLLLVVGASWLLARILAWTYAFYHNGRRLRCFPQPRKQNWFLGHL 64

Query: 64  LLMKPDG---REFFQQIIEYTEEYRHMPLLKLWVGPV-PMVALYNAENVEVILTSSKQID 119
            L+ P     R   Q +  Y + +        W+GP+ P++ L + + V  ++ +S  I 
Sbjct: 65  GLVTPTEEGLRVLTQLVATYPQGFVR------WLGPITPIINLCHPDIVRSVINTSDAIT 118

Query: 120 KSSM--YKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKL 177
              +  YK L+PWLG GLL S G+KWR  R++LTP FHF IL+ ++ I ++ ANI+  K 
Sbjct: 119 DKDIVFYKTLKPWLGDGLLLSVGDKWRHHRRLLTPAFHFNILKPYIKIFSKSANIMHAKW 178

Query: 178 EKHINQEAFNC---FFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRI 234
           ++ +  E   C   F +I+L  LD + +     +   Q    SEY+ A+  +S ++ +R 
Sbjct: 179 QR-LAMEGSTCLDVFEHISLMTLDSLQKCIFSFDSNCQEKP-SEYITAIMELSALVVKRN 236

Query: 235 KMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKN 294
              + + D  Y +   G    ++ +++H FT++VI ER   + +      D    A +K+
Sbjct: 237 NQFFRYKDFLYFLTPCGRRFHRACRLVHDFTDAVIQERRRTLTSQGV---DDFLQAKAKS 293

Query: 295 KRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKK 354
           K   F+D+LL   D  G  LS EDIR E DTFMF GHDTTA+ ++W LY L  +PE Q++
Sbjct: 294 KTLDFIDVLLLSEDKNGKELSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQER 353

Query: 355 VDHELDDVFGKSDRPATVE--DLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYR 412
              E+ ++  K   P  +E  DL +L +L   +KE+LRL P +P FAR  ++D  +   R
Sbjct: 354 CRQEVQELL-KDREPKEIEWDDLAQLPFLTMCLKESLRLHPPIPTFARGCTQDVVLPDSR 412

Query: 413 VL-KGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQK 471
           V+ KG    I  +A+H +P  +P+PE + P RF PENAQ R P A++PFSAGPRNCIGQK
Sbjct: 413 VIPKGNVCNINIFAIHHNPSVWPDPEVYDPFRFDPENAQKRSPMAFIPFSAGPRNCIGQK 472

Query: 472 FAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLK 518
           FA+ E K +L+  L  F I  + +  E     +++LR  +G+W++++
Sbjct: 473 FAMAEMKVVLALTLLRFRILPDHR--EPRRTPEIVLRAEDGLWLRVE 517


>gi|150036266 cytochrome P450, family 4, subfamily F, polypeptide 12
           [Homo sapiens]
          Length = 524

 Score =  280 bits (717), Expect = 2e-75
 Identities = 175/529 (33%), Positives = 287/529 (54%), Gaps = 28/529 (5%)

Query: 5   WLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHAL 64
           WLGL    +  W     L + G+ L+  +L    ++    ++++  P   +     GH  
Sbjct: 8   WLGLRPVAMSPW--LLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNWFWGHLG 65

Query: 65  LMKPDG---REFFQQIIEYTEEYRHMPLLKLWVGPV-PMVALYNAENVEVILTSSKQI-D 119
           L+ P     ++  Q    Y++ +       +W+GP+ P + L + + +  I  +S  I  
Sbjct: 66  LITPTEEGLKDSTQMSATYSQGFT------VWLGPIIPFIVLCHPDTIRSITNASAAIAP 119

Query: 120 KSSMY-KFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLE 178
           K +++ +FL+PWLG G+L S G+KW   R+MLTP FHF IL+ ++ I N+ ANI++ K +
Sbjct: 120 KDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQ 179

Query: 179 KHINQEA---FNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIK 235
            H+  E     + F +I+L  LD + +     +   Q    SEY+  +  +S ++ +R +
Sbjct: 180 -HLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERP-SEYIATILELSALVEKRSQ 237

Query: 236 MPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNK 295
                +D  Y +  +G    ++ +++H FT++VI ER   +        D      +K+K
Sbjct: 238 HILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIRERRRTLPTQGI---DDFFKDKAKSK 294

Query: 296 RRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKV 355
              F+D+LL   D++G  LS EDIR E DTFMF GHDTTA+ ++W LY L  +PE Q++ 
Sbjct: 295 TLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERC 354

Query: 356 DHELDDVFGKSDRPATVE--DLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRV 413
             E+ ++    D P  +E  DL +L +L   +KE+LRL P  P  +R  ++D  +   RV
Sbjct: 355 RQEVQELLKDRD-PKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRV 413

Query: 414 L-KGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKF 472
           + KG   +I    +H +P  +P+PE + P RF PEN++GR P A++PFSAGPRNCIGQ F
Sbjct: 414 IPKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAF 473

Query: 473 AVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRN 521
           A+ E K +L+ +L HF    +       LE  LI+R   G+W++++  N
Sbjct: 474 AMAEMKVVLALMLLHFRFLPDHTEPRRKLE--LIMRAEGGLWLRVEPLN 520


>gi|193083180 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  280 bits (716), Expect = 2e-75
 Identities = 183/538 (34%), Positives = 289/538 (53%), Gaps = 38/538 (7%)

Query: 5   WLGL------VWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYP 58
           WLGL       W  LLL G        G+ L+  +L    ++    ++++  P   +   
Sbjct: 8   WLGLGPVAASPWLLLLLVG--------GSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNW 59

Query: 59  LVGHALLMKP--DGREFFQQIIE-YTEEYRHMPLLKLWVGPV-PMVALYNAENVEVILTS 114
             GH  L+ P  +G +   Q++  Y + +      KLW+GP  P++ L + + +  I ++
Sbjct: 60  FWGHQGLVTPTEEGMKTLTQLVTTYPQGF------KLWLGPTFPLLILCHPDIIRPITSA 113

Query: 115 SKQIDKSSM--YKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANI 172
           S  +    M  Y FL+PWLG GLL S G+KW   R+MLTP FHF IL+ ++ I N+  NI
Sbjct: 114 SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNI 173

Query: 173 LVKKLEKHINQEA--FNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMI 230
           +  K ++  ++ +   + F +I+L  LD + +         Q    SEY+ A+  +S  +
Sbjct: 174 MHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKP-SEYIAAILELSAFV 232

Query: 231 FRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSA 290
            +R +   L  D  Y +  +G   +++  ++H FT++VI ER   +        D     
Sbjct: 233 EKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGI---DDFLKN 289

Query: 291 PSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPE 350
            +K+K   F+D+LL   D++G  LS EDIR E DTFMFEGHDTTA+ ++W LY L  +PE
Sbjct: 290 KAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPE 349

Query: 351 VQKKVDHELDDVFGKSDRPATVE--DLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEV 408
            Q++   E+ ++  K   P  +E  DL +L +L   IKE+LRL P VP+ +R  ++D  +
Sbjct: 350 YQEQCRQEVQELL-KDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVL 408

Query: 409 AGYRVL-KGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNC 467
              RV+ KG   +I    +H +P  +P+PE + P RF  EN + R P A++PFSAGPRNC
Sbjct: 409 PDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNC 468

Query: 468 IGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADER 525
           IGQ FA+ E K +L+  L HF I       E   + +LILR   G+W++++   A+ +
Sbjct: 469 IGQAFAMAEMKVVLALTLLHFRILPT--HTEPRRKPELILRAEGGLWLRVEPLGANSQ 524


>gi|193083178 cytochrome P450 family 4 subfamily F polypeptide 11
           [Homo sapiens]
          Length = 524

 Score =  280 bits (716), Expect = 2e-75
 Identities = 183/538 (34%), Positives = 289/538 (53%), Gaps = 38/538 (7%)

Query: 5   WLGL------VWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYP 58
           WLGL       W  LLL G        G+ L+  +L    ++    ++++  P   +   
Sbjct: 8   WLGLGPVAASPWLLLLLVG--------GSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNW 59

Query: 59  LVGHALLMKP--DGREFFQQIIE-YTEEYRHMPLLKLWVGPV-PMVALYNAENVEVILTS 114
             GH  L+ P  +G +   Q++  Y + +      KLW+GP  P++ L + + +  I ++
Sbjct: 60  FWGHQGLVTPTEEGMKTLTQLVTTYPQGF------KLWLGPTFPLLILCHPDIIRPITSA 113

Query: 115 SKQIDKSSM--YKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANI 172
           S  +    M  Y FL+PWLG GLL S G+KW   R+MLTP FHF IL+ ++ I N+  NI
Sbjct: 114 SAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNI 173

Query: 173 LVKKLEKHINQEA--FNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMI 230
           +  K ++  ++ +   + F +I+L  LD + +         Q    SEY+ A+  +S  +
Sbjct: 174 MHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKP-SEYIAAILELSAFV 232

Query: 231 FRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSA 290
            +R +   L  D  Y +  +G   +++  ++H FT++VI ER   +        D     
Sbjct: 233 EKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGI---DDFLKN 289

Query: 291 PSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPE 350
            +K+K   F+D+LL   D++G  LS EDIR E DTFMFEGHDTTA+ ++W LY L  +PE
Sbjct: 290 KAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPE 349

Query: 351 VQKKVDHELDDVFGKSDRPATVE--DLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEV 408
            Q++   E+ ++  K   P  +E  DL +L +L   IKE+LRL P VP+ +R  ++D  +
Sbjct: 350 YQEQCRQEVQELL-KDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVL 408

Query: 409 AGYRVL-KGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNC 467
              RV+ KG   +I    +H +P  +P+PE + P RF  EN + R P A++PFSAGPRNC
Sbjct: 409 PDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNC 468

Query: 468 IGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRRNADER 525
           IGQ FA+ E K +L+  L HF I       E   + +LILR   G+W++++   A+ +
Sbjct: 469 IGQAFAMAEMKVVLALTLLHFRILPT--HTEPRRKPELILRAEGGLWLRVEPLGANSQ 524


>gi|158138530 cytochrome P450, family 4, subfamily F, polypeptide 22
           [Homo sapiens]
          Length = 531

 Score =  278 bits (710), Expect = 1e-74
 Identities = 171/498 (34%), Positives = 274/498 (55%), Gaps = 18/498 (3%)

Query: 29  LVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMP 88
           L+L  L+   S+    +++R  P   R   L+GH  +  P+     Q   +  +   H+ 
Sbjct: 38  LLLRFLRLCRSFYITCRRLRCFPQPPRRNWLLGHLGMYLPN-EAGLQDEKKVLDNMHHV- 95

Query: 89  LLKLWVGPV-PMVALYNAENVEVILTSSKQIDKSS--MYKFLEPWLGLGLLTSTGNKWRS 145
            L +W+GPV P++ L + + ++ +L +S  I       Y FL+PWLG GLL S G+KW  
Sbjct: 96  -LLVWMGPVLPLLVLVHPDYIKPLLGASAAIAPKDDLFYGFLKPWLGDGLLLSKGDKWSR 154

Query: 146 RRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEA---FNCFFYITLCALDIICE 202
            R++LTP FHF IL+ ++ I N+ A+I+  K  +H+ + +    + F +I+L  LD + +
Sbjct: 155 HRRLLTPAFHFDILKPYMKIFNQSADIMHAKW-RHLAEGSAVSLDMFEHISLMTLDSLQK 213

Query: 203 TAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILH 262
                N   Q    S+Y+ A+  +S +  RR      +LD  Y    +G   +++  ++H
Sbjct: 214 CVFSYNSNCQEKM-SDYISAIIELSALSVRRQYRLHHYLDFIYYRSADGRRFRQACDMVH 272

Query: 263 TFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREE 322
            FT  VI ER   +      +G        + K   F+D+LL   D++G  LS EDIR E
Sbjct: 273 HFTTEVIQERRRALRQ----QGAEAWLKAKQGKTLDFIDVLLLARDEDGKELSDEDIRAE 328

Query: 323 VDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVF-GKSDRPATVEDLKKLRYL 381
            DTFMFEGHDTT++ I+W L+ L   PE Q+K   E+ +V  G+       +DL +L + 
Sbjct: 329 ADTFMFEGHDTTSSGISWMLFNLAKYPEYQEKCREEIQEVMKGRELEELEWDDLTQLPFT 388

Query: 382 ECVIKETLRLFPSVPLFARSVSEDCEVAGYRVL-KGTEAVIIPYALHRDPRYFPNPEEFQ 440
              IKE+LR +P V L +R  +ED ++   R++ KG   ++  Y  H +P  +P+ + + 
Sbjct: 389 TMCIKESLRQYPPVTLVSRQCTEDIKLPDGRIIPKGIICLVSIYGTHHNPTVWPDSKVYN 448

Query: 441 PERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELG 500
           P RF P+N Q R P AYVPFSAGPRNCIGQ FA+ E + +++  L  F +  ++ R ++ 
Sbjct: 449 PYRFDPDNPQQRSPLAYVPFSAGPRNCIGQSFAMAELRVVVALTLLRFRLSVDRTR-KVR 507

Query: 501 LEGQLILRPSNGIWIKLK 518
            + +LILR  NG+W+K++
Sbjct: 508 RKPELILRTENGLWLKVE 525


>gi|29837648 cytochrome P450, family 4, subfamily X, polypeptide 1
           [Homo sapiens]
          Length = 509

 Score =  276 bits (706), Expect = 3e-74
 Identities = 168/501 (33%), Positives = 270/501 (53%), Gaps = 27/501 (5%)

Query: 29  LVLSLLQRVASYARKWQ---QMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYR 85
           L L LLQ +  Y R+ +    +RP P     +  +GH   ++ D  E  ++IIE     +
Sbjct: 22  LALGLLQAIKLYLRRQRLLRDLRPFPAPPTHW-FLGHQKFIQDDNMEKLEEIIE-----K 75

Query: 86  HMPLLKLWVGPVP-MVALYNAENVEVILTSSKQIDKSSMY--KFLEPWLGLGLLTSTGNK 142
           +      W+GP      +Y+ +  + +L+ +   D  S Y  KF  P LG GL    G K
Sbjct: 76  YPRAFPFWIGPFQAFFCIYDPDYAKTLLSRT---DPKSQYLQKFSPPLLGKGLAALDGPK 132

Query: 143 WRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQE--AFNCFFYITLCALDII 200
           W   R++LTP FHF IL+ ++++M     +++ K EK  + +  +   + +I   +LDII
Sbjct: 133 WFQHRRLLTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDII 192

Query: 201 CETAMGKNIGAQSNDDSE-YVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQ 259
            + A  K    Q+N   + Y +A++ +S++IF R+       D+ + +  +G+  +K  +
Sbjct: 193 MKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSR 252

Query: 260 ILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDI 319
           +L+ +T+++I ER   + A     G  + + P K K + FLD++LS  D+ G+  S  D+
Sbjct: 253 VLNQYTDTIIQERKKSLQA-----GVKQDNTP-KRKYQDFLDIVLSAKDESGSSFSDIDV 306

Query: 320 REEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLR 379
             EV TF+  GHDT AA+I+W LY L  NPE Q++   E+  + G      T + L ++ 
Sbjct: 307 HSEVSTFLLAGHDTLAASISWILYCLALNPEHQERCREEVRGILGDGSS-ITWDQLGEMS 365

Query: 380 YLECVIKETLRLFPSVPLFARSVSEDCEVA-GYRVLKGTEAVIIPYALHRDPRYFPNPEE 438
           Y    IKET RL P+VP  +R +S+      G  +  G   V+  + LH +P  + NP+ 
Sbjct: 366 YTTMCIKETCRLIPAVPSISRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKV 425

Query: 439 FQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREE 498
           F P RF  EN+  RHPYAY+PFSAG RNCIGQ+FA++E K  ++ IL HF +  +  R  
Sbjct: 426 FDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTR-P 484

Query: 499 LGLEGQLILRPSNGIWIKLKR 519
           L      IL+P NG+++ LK+
Sbjct: 485 LTFPNHFILKPKNGMYLHLKK 505


>gi|119220562 cytochrome P450, family 4, subfamily F, polypeptide 3
           [Homo sapiens]
          Length = 520

 Score =  275 bits (703), Expect = 7e-74
 Identities = 158/434 (36%), Positives = 250/434 (57%), Gaps = 15/434 (3%)

Query: 93  WVGPV-PMVALYNAENVEVILTSSKQIDKSS--MYKFLEPWLGLGLLTSTGNKWRSRRKM 149
           WVGP   +V +++   ++ +L +   I       Y FL+PWLG GLL S G KW   R+M
Sbjct: 91  WVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVFYSFLKPWLGDGLLLSAGEKWSRHRRM 150

Query: 150 LTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEA--FNCFFYITLCALDIICETAMGK 207
           LTP FHF IL+ ++ I NE  NI+  K +   ++ +   + F +I+L  LD + +     
Sbjct: 151 LTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARLDMFEHISLMTLDSLQKCVFSF 210

Query: 208 NIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNS 267
           +   Q    SEY+ A+  +S ++ +R +   L++D  Y +  +G   +++ +++H FT++
Sbjct: 211 DSHCQEKP-SEYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRACRLVHDFTDA 269

Query: 268 VIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFM 327
           VI ER   + +      D    A +K+K   F+D+LL   D++G +LS EDIR E DTFM
Sbjct: 270 VIQERRRTLPSQGV---DDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFM 326

Query: 328 FEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVE--DLKKLRYLECVI 385
           FEGHDTTA+ ++W LY L  +PE Q++   E+ ++  K   P  +E  DL +L +L   I
Sbjct: 327 FEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELL-KDREPKEIEWDDLAQLPFLTMCI 385

Query: 386 KETLRLFPSVPLFARSVSEDCEVAGYRVL-KGTEAVIIPYALHRDPRYFPNPEEFQPERF 444
           KE+LRL P VP  +R  ++D  +   RV+ KG   +I  +  H +P  +P+PE + P RF
Sbjct: 386 KESLRLHPPVPAVSRCCTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRF 445

Query: 445 FPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQ 504
            P+N + R P A++PFSAGPRNCIGQ FA+ E K +L   L  F +  +    E   + +
Sbjct: 446 DPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPD--HTEPRRKPE 503

Query: 505 LILRPSNGIWIKLK 518
           L+LR   G+W++++
Sbjct: 504 LVLRAEGGLWLRVE 517


>gi|158937242 cytochrome P450, family 4, subfamily A, polypeptide 11
           [Homo sapiens]
          Length = 519

 Score =  252 bits (643), Expect = 7e-67
 Identities = 173/516 (33%), Positives = 275/516 (53%), Gaps = 29/516 (5%)

Query: 15  LWGAASALSLAGASLVLSLL--QRVASYA-RKWQ----QMRPIPTVARAYPLVGHALLMK 67
           L G  S +  A + L+L LL  + V  Y  R+W     Q  P P    ++ L GH   ++
Sbjct: 11  LLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPP---SHWLFGHIQELQ 67

Query: 68  PDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFL 127
            D  +  Q+I ++ E +       LW G V  V LY+ + ++VIL  S      S Y+FL
Sbjct: 68  QD--QELQRIQKWVETFPSACPHWLWGGKV-RVQLYDPDYMKVILGRSDPKSHGS-YRFL 123

Query: 128 EPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEA-F 186
            PW+G GLL   G  W   R+MLTP FH+ IL+ ++ +M +   +++ K E+ + Q++  
Sbjct: 124 APWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPL 183

Query: 187 NCFFYITLCALDIICETAMGKNIGAQSNDDSE-YVRAVYRMSEMIFRRIKMPWLWLDLWY 245
             F +++L  LD I + A       Q + +S+ Y++A+  ++ ++F R++  +   D  Y
Sbjct: 184 EVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIY 243

Query: 246 LMFKEG-WEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL 304
            +   G W H+ + Q+ H  T+ VI  R  ++        +G      + +   FLD+LL
Sbjct: 244 SLTSAGRWTHR-ACQLAHQHTDQVIQLRKAQLQK------EGELEKIKRKRHLDFLDILL 296

Query: 305 SVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFG 364
               + G+ LS +D+R EVDTFMFEGHDTTA+ I+W LY L ++P+ Q++   E+  + G
Sbjct: 297 LAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLG 356

Query: 365 KSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVL-KGTEAVIIP 423
                 T   L ++ Y    IKE LRL+P VP   R +S        R L KG   ++  
Sbjct: 357 -DGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSI 415

Query: 424 YALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSC 483
           Y LH +P+ +PNPE F P RF P +AQ  H +A++PFS G RNCIG++FA+ E K   + 
Sbjct: 416 YGLHHNPKVWPNPEVFDPFRFAPGSAQ--HSHAFLPFSGGSRNCIGKQFAMNELKVATAL 473

Query: 484 ILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKR 519
            L  F +  +  R  + +  +L+L+  NGI ++L+R
Sbjct: 474 TLLRFELLPDPTRIPIPI-ARLVLKSKNGIHLRLRR 508


>gi|153218660 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform b [Homo sapiens]
          Length = 511

 Score =  248 bits (634), Expect = 7e-66
 Identities = 166/522 (31%), Positives = 263/522 (50%), Gaps = 23/522 (4%)

Query: 1   MAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLV 60
           M   +L L +  L LW +   L L    L+  LL+R  + A+   +    PT    + L 
Sbjct: 1   MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRR-QTLAKAMDKFPGPPT----HWLF 55

Query: 61  GHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGP-VPMVALYNAENVEVILTSSKQID 119
           GHAL ++  G     +++ +  ++ +     LW G  +  + +Y  +  + + +      
Sbjct: 56  GHALEIQETGS--LDKVVSWAHQFPYAH--PLWFGQFIGFLNIYEPDYAKAVYSRGDP-K 110

Query: 120 KSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEK 179
              +Y F   W+G GLL   G KW   RK+LTP FH+ +L+ ++ +  E   I++ K E+
Sbjct: 111 APDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEE 170

Query: 180 HINQ-EAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPW 238
              + ++F+ F  +   AL+ + +   G+      + DS Y  AV  ++ ++ +R+    
Sbjct: 171 KAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQ 230

Query: 239 LWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRA 298
              D  Y +   G    ++ Q+ H  T+ VI ER   +        D +     +N+R  
Sbjct: 231 YHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ-------DEKVRKKIQNRRHL 283

Query: 299 -FLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDH 357
            FLD+LL   D++  +LS  D+R EVDTFMFEGHDTT + I+W LY +   PE Q +   
Sbjct: 284 DFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCRE 343

Query: 358 ELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGT 417
           E+ ++ G  D     +DL K+ YL   IKE+ RL+P VP   R +S+       R L   
Sbjct: 344 EVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAG 402

Query: 418 EAVIIP-YALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVME 476
             + +  YALHR+   +P+PE F   RF  ENA  RHP+A++PFSAGPRNCIGQ+FA+ E
Sbjct: 403 SLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSE 462

Query: 477 EKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLK 518
            K + +  L  F    +  R  + +  QL+LR  NG  + LK
Sbjct: 463 MKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLK 503


>gi|153218662 cytochrome P450, family 4, subfamily B, polypeptide 1
           isoform a [Homo sapiens]
          Length = 512

 Score =  247 bits (631), Expect = 2e-65
 Identities = 167/523 (31%), Positives = 265/523 (50%), Gaps = 24/523 (4%)

Query: 1   MAGLWLGLVWQKLLLWGAASALSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLV 60
           M   +L L +  L LW +   L L    L+  LL+R  + A+   +    PT    + L 
Sbjct: 1   MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRR-QTLAKAMDKFPGPPT----HWLF 55

Query: 61  GHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGP-VPMVALYNAENVEVILTSSKQID 119
           GHAL ++  G     +++ +  ++ +     LW G  +  + +Y  +  + + +      
Sbjct: 56  GHALEIQETGS--LDKVVSWAHQFPYAH--PLWFGQFIGFLNIYEPDYAKAVYSRGDP-K 110

Query: 120 KSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEK 179
              +Y F   W+G GLL   G KW   RK+LTP FH+ +L+ ++ +  E   I++ K E+
Sbjct: 111 APDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEE 170

Query: 180 HINQ-EAFNCFFYITLCALDIICETAMGK-NIGAQSNDDSEYVRAVYRMSEMIFRRIKMP 237
              + ++F+ F  +   AL+ + +   G+ + G   + DS Y  AV  ++ ++ +R+   
Sbjct: 171 KAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHSRDSSYYLAVSDLTLLMQQRLVSF 230

Query: 238 WLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRR 297
               D  Y +   G    ++ Q+ H  T+ VI ER   +        D +     +N+R 
Sbjct: 231 QYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQ-------DEKVRKKIQNRRH 283

Query: 298 A-FLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVD 356
             FLD+LL   D++  +LS  D+R EVDTFMFEGHDTT + I+W LY +   PE Q +  
Sbjct: 284 LDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCR 343

Query: 357 HELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKG 416
            E+ ++ G  D     +DL K+ YL   IKE+ RL+P VP   R +S+       R L  
Sbjct: 344 EEVREILGDQDF-FQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPA 402

Query: 417 TEAVIIP-YALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVM 475
              + +  YALHR+   +P+PE F   RF  ENA  RHP+A++PFSAGPRNCIGQ+FA+ 
Sbjct: 403 GSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMS 462

Query: 476 EEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLK 518
           E K + +  L  F    +  R  + +  QL+LR  NG  + LK
Sbjct: 463 EMKVVTAMCLLRFEFSLDPSRLPIKMP-QLVLRSKNGFHLHLK 504


>gi|62952506 cytochrome P450, family 4, subfamily A, polypeptide 22
           [Homo sapiens]
          Length = 519

 Score =  234 bits (596), Expect = 2e-61
 Identities = 166/515 (32%), Positives = 268/515 (52%), Gaps = 28/515 (5%)

Query: 15  LWGAASALSLAGASLVLSLLQRVASYA--RKWQ----QMRPIPTVARAYPLVGHALLMKP 68
           L G +  L +    ++L LL + A     R+W     Q  P P    ++ L GH    + 
Sbjct: 12  LGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPP---SHWLFGHIQEFQH 68

Query: 69  DGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLE 128
           D  +  Q+I E  + +       +W G V  V LY+ + ++VIL  S      S YKFL 
Sbjct: 69  D--QELQRIQERVKTFPSACPYWIWGGKV-RVQLYDPDYMKVILGRSDPKSHGS-YKFLA 124

Query: 129 PWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEA-FN 187
           P +G GLL   G  W   R+MLTP FH  IL+ ++ +M +   +++ K E+ + Q++   
Sbjct: 125 PRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLE 184

Query: 188 CFFYITLCALDIICETAMGKNIGAQSNDDSE-YVRAVYRMSEMIFRRIKMPWLWLDLWYL 246
            F +++L  LD I ++A       Q + +S+ Y++A+  ++ ++F  ++  +   D  Y 
Sbjct: 185 VFQHVSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYS 244

Query: 247 MFKEG-WEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLS 305
           +   G W H+ + Q+ H  T+ VI  R  ++        +G      + +   FLD+LL 
Sbjct: 245 LTSAGRWTHR-ACQLAHQHTDQVIQLRKAQLQK------EGELEKIKRKRHLDFLDILLL 297

Query: 306 VTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGK 365
              + G+ LS +D+R EVDTFMFEGHDTTA+ I+W LY L ++P+ Q++   E+  + G 
Sbjct: 298 AKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLLG- 356

Query: 366 SDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVL-KGTEAVIIPY 424
                T   L ++ Y    IKE LRL+P VP   R +S        R L KG   ++  Y
Sbjct: 357 DGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIY 416

Query: 425 ALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCI 484
            LH +P+ +PN E F P RF P +AQ  H +A++PFS G RNCIG++FA+ + K   +  
Sbjct: 417 GLHHNPKVWPNLEVFDPSRFAPGSAQ--HSHAFLPFSGGSRNCIGKQFAMNQLKVARALT 474

Query: 485 LRHFWIESNQKREELGLEGQLILRPSNGIWIKLKR 519
           L  F +  +  R  + +  +L+L+  NGI ++L+R
Sbjct: 475 LLRFELLPDPTRIPIPM-ARLVLKSKNGIHLRLRR 508


>gi|30023836 cytochrome P450 4Z1 [Homo sapiens]
          Length = 505

 Score =  230 bits (587), Expect = 2e-60
 Identities = 157/495 (31%), Positives = 252/495 (50%), Gaps = 21/495 (4%)

Query: 31  LSLLQRVASYARKWQQMRPIPTVAR--AYPLVGHALLMKPDGREFFQQIIEYTEEYRHMP 88
           L L Q +  Y R+   +R +       A+   GH         E + +++E     ++  
Sbjct: 24  LLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKEFEVYHKLME-----KYPC 78

Query: 89  LLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRK 148
            + LWVGP  M    +  +   IL   +    +  +K LE W+G GL+T  G+KW+  R+
Sbjct: 79  AVPLWVGPFTMFFSVHDPDYAKILLKRQDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQ 138

Query: 149 MLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQEA-FNCFFYITLCALDIICETAMGK 207
           ++ P F+ +IL+ F+ +M+E   +++ K E+HI Q +    F +++L  LD I + A   
Sbjct: 139 IVKPGFNISILKIFITMMSESVRMMLNKWEEHIAQNSRLELFQHVSLMTLDSIMKCAFSH 198

Query: 208 --NIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKSLQILHTFT 265
             +I   S  DS Y++AV+ +S++  +R+       DL +    +G    K  Q LH FT
Sbjct: 199 QGSIQLDSTLDS-YLKAVFNLSKISNQRMNNFLHHNDLVFKFSSQGQIFSKFNQELHQFT 257

Query: 266 NSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDT 325
             VI +R   +        D      ++ +R  FLD+LLS   +     S  D++ EV T
Sbjct: 258 EKVIQDRKESLK-------DKLKQDTTQKRRWDFLDILLSAKSENTKDFSEADLQAEVKT 310

Query: 326 FMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVI 385
           FMF GHDTT++AI+W LY L   PE Q++   E+ ++ G      T E L ++ Y    I
Sbjct: 311 FMFAGHDTTSSAISWILYCLAKYPEHQQRCRDEIRELLGDGSS-ITWEHLSQMPYTTMCI 369

Query: 386 KETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIP-YALHRDPRYFPNPEEFQPERF 444
           KE LRL+  V   +R + +       R L     V I  +ALH +P ++ +P+ F P RF
Sbjct: 370 KECLRLYAPVVNISRLLDKPITFPDGRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRF 429

Query: 445 FPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQ 504
             EN++  HPYA++PFSAG RNCIGQ FA++E K  ++  L  F +  +  R    +  Q
Sbjct: 430 SRENSEKIHPYAFIPFSAGLRNCIGQHFAIIECKVAVALTLLRFKLAPDHSRPPQPVR-Q 488

Query: 505 LILRPSNGIWIKLKR 519
           ++L+  NGI +  K+
Sbjct: 489 VVLKSKNGIHVFAKK 503


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score =  170 bits (431), Expect = 3e-42
 Identities = 136/518 (26%), Positives = 252/518 (48%), Gaps = 55/518 (10%)

Query: 24  LAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEE 83
           L   SLVL  L    ++    +   P PT     PL+G+ L  +    +F       TE 
Sbjct: 14  LLAVSLVLLYLYGTRTHGLFKRLGIPGPT---PLPLLGNVLSYRQGLWKFD------TEC 64

Query: 84  YRHMPLLKLW---VGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEP--WLGLGLLTS 138
           Y+     K+W    G +P++A+ + + +  +L   +     +  + L P  ++   +  +
Sbjct: 65  YKKYG--KMWGTYEGQLPVLAITDPDVIRTVLVK-ECYSVFTNRRSLGPVGFMKSAISLA 121

Query: 139 TGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQ-------EAFNCFFY 191
              +W+  R +L+PTF    L++   I+ +  ++LV+ L +   +       + F  +  
Sbjct: 122 EDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAY-- 179

Query: 192 ITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEG 251
               ++D+I  T+ G NI + +N    +V +  +  +  F    +  L+L +    F   
Sbjct: 180 ----SMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGF----LDPLFLSIILFPFLTP 231

Query: 252 WEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEG 311
                ++ +    T + +++  N M  +              +K++  LD L  + D + 
Sbjct: 232 VFEALNVSLFPKDTINFLSKSVNRMKKSR-----------LNDKQKHRLDFLQLMIDSQN 280

Query: 312 NR-------LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFG 364
           ++       LS  ++  +   F+F G++TT++ ++++LY L ++P+VQ+K+  E+D V  
Sbjct: 281 SKETESHKALSDLELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL- 339

Query: 365 KSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPY 424
            +  P T + + ++ YL+ V+ ETLRLFP      R+  +D E+ G  + KG+  VI  Y
Sbjct: 340 PNKAPPTYDAVVQMEYLDMVVNETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTY 399

Query: 425 ALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCI 484
           ALH DP+Y+  PEEF+PER F +      PY Y PF  GPRNCIG +FA+M  K  L  +
Sbjct: 400 ALHHDPKYWTEPEEFRPER-FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRV 458

Query: 485 LRHFWIESNQKRE-ELGLEGQLILRPSNGIWIKLKRRN 521
           L++F  +  ++ +  L L+ Q +L+P   I +K+  R+
Sbjct: 459 LQNFSFKPCKETQIPLKLDTQGLLQPEKPIVLKVDSRD 496


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score =  168 bits (426), Expect = 1e-41
 Identities = 121/458 (26%), Positives = 220/458 (48%), Gaps = 47/458 (10%)

Query: 86  HMPLLKLWV---GPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTST--- 139
           H    K+W    G  P++A+ + + ++ +L      +  S++    P+  +G + S    
Sbjct: 65  HKKYGKVWGFYDGQQPVLAITDPDMIKTVLVK----ECYSVFTNRRPFGPVGFMKSAISI 120

Query: 140 --GNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHIN-------QEAFNCFF 190
               +W+  R +L+PTF    L++ + I+ +  ++LV+ L +          ++ F  + 
Sbjct: 121 AEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAY- 179

Query: 191 YITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKE 250
                ++D+I  T+ G NI + +N    +V    ++    F         LD ++L    
Sbjct: 180 -----SMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDF---------LDPFFLSITV 225

Query: 251 GWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLL----SV 306
                  + IL      V              R        ++  R  FL L++    S 
Sbjct: 226 ---FPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSK 282

Query: 307 TDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKS 366
             +    LS  ++  +   F+F G++TT++ +++ +Y L ++P+VQ+K+  E+D V   +
Sbjct: 283 ETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVL-PN 341

Query: 367 DRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYAL 426
             P T + + ++ YL+ V+ ETLRLFP      R   +D E+ G  + KG   +I  YAL
Sbjct: 342 KAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYAL 401

Query: 427 HRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILR 486
           HRDP+Y+  PE+F PERF  +N     PY Y PF +GPRNCIG +FA+M  K  L  +L+
Sbjct: 402 HRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQ 461

Query: 487 HFWIESNQKRE---ELGLEGQLILRPSNGIWIKLKRRN 521
           +F  +  ++ +   +L L G  +L+P   + +K++ R+
Sbjct: 462 NFSFKPCKETQIPLKLSLGG--LLQPEKPVVLKVESRD 497


>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 2 [Homo sapiens]
          Length = 503

 Score =  162 bits (410), Expect = 7e-40
 Identities = 121/461 (26%), Positives = 222/461 (48%), Gaps = 44/461 (9%)

Query: 79  EYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTS 138
           E  E+Y  M    L+ G  PM+ + + + ++ +L      +  S++    P   +G L S
Sbjct: 63  ECNEKYGEM--WGLYEGQQPMLVIMDPDMIKTVLVK----ECYSVFTNQMPLGPMGFLKS 116

Query: 139 T-----GNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHI-NQEAFNCFFYI 192
                   +W+  R +L+P F     ++ + I+++  ++LV+ L +   N ++ N   + 
Sbjct: 117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFF 176

Query: 193 TLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGW 252
               +D+I  T  G N+ + +N    +++ + ++ ++ F     P+L L   +      +
Sbjct: 177 GAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLD---PFLLLISLFPFLTPVF 233

Query: 253 EHKK----SLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTD 308
           E          + H   NS+  ER  E                 K+K++  +D    + D
Sbjct: 234 EALNIGLFPKDVTHFLKNSI--ERMKESRL--------------KDKQKHRVDFFQQMID 277

Query: 309 DEGNR-------LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDD 361
            + ++       LS  ++  +    +F  +DTT+  + + +Y L ++P+VQ+K+  E+D 
Sbjct: 278 SQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDA 337

Query: 362 VFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVI 421
           V   +  P T + L ++ YL+ V+ ETLRLFP V    R   +D E+ G  + KG   ++
Sbjct: 338 VL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMV 396

Query: 422 IPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTIL 481
             YALH DP+Y+  PE+F PERF  +N      Y Y+PF AGPRNCIG +FA+   K  +
Sbjct: 397 PIYALHHDPKYWTEPEKFCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAV 456

Query: 482 SCILRHFWIESNQKRE-ELGLEGQLILRPSNGIWIKLKRRN 521
              L++F  +  ++ +  L L+   IL+P   I +K+  R+
Sbjct: 457 IRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRD 497


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score =  158 bits (400), Expect = 1e-38
 Identities = 125/477 (26%), Positives = 232/477 (48%), Gaps = 39/477 (8%)

Query: 24  LAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEE 83
           L   SL+L  L    ++    +   P PT     P +G+AL  +   + ++   +E  ++
Sbjct: 14  LLAVSLILLYLYGTRTHGLFKKLGIPGPT---PLPFLGNALSFR---KGYWTFDMECYKK 67

Query: 84  YRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTST---- 139
           YR +    ++    PM+A+ + + ++ +L      +  S++    P+  +G + +     
Sbjct: 68  YRKV--WGIYDCQQPMLAITDPDMIKTVLVK----ECYSVFTNRRPFGPVGFMKNAISIA 121

Query: 140 -GNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQ-EAFNCFFYITLCAL 197
              +W+  R +L+PTF    L++ + I+ +  ++LV+ L +     +           ++
Sbjct: 122 EDEEWKRIRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKHVFGAYSM 181

Query: 198 DIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHKKS 257
           D+I  T+ G +I + +N    +V    ++         + +  LD + L  K        
Sbjct: 182 DVITSTSFGVSIDSLNNPQDPFVENTKKL---------LRFNPLDPFVLSIKVFPFLTPI 232

Query: 258 LQILH--TFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNR-- 313
           L+ L+   F   VI+     +   ++    GR     K+ R  FL L++   + + +   
Sbjct: 233 LEALNITVFPRKVISFLTKSVKQIKE----GRLKETQKH-RVDFLQLMIDSQNSKDSETH 287

Query: 314 --LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPAT 371
             LS  ++  +   F+F G++TT++ +++ +Y L ++P+VQ+KV  E+D V   +  P T
Sbjct: 288 KALSDLELMAQSIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVL-PNKAPPT 346

Query: 372 VEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPR 431
            + + +L YL+ V+ ETLRLFP      R   +D E+ G  + KG   +I  Y LH DP+
Sbjct: 347 YDTVLQLEYLDMVVNETLRLFPVAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHHDPK 406

Query: 432 YFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHF 488
           Y+  PE+F PERF  +N     PY Y PF +GPRNCIG +FA++  K  L  +L++F
Sbjct: 407 YWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNF 463


>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 1 [Homo sapiens]
          Length = 504

 Score =  157 bits (398), Expect = 2e-38
 Identities = 121/462 (26%), Positives = 222/462 (48%), Gaps = 45/462 (9%)

Query: 79  EYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTS 138
           E  E+Y  M    L+ G  PM+ + + + ++ +L      +  S++    P   +G L S
Sbjct: 63  ECNEKYGEM--WGLYEGQQPMLVIMDPDMIKTVLVK----ECYSVFTNQMPLGPMGFLKS 116

Query: 139 T-----GNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHI-NQEAFNCFFYI 192
                   +W+  R +L+P F     ++ + I+++  ++LV+ L +   N ++ N   + 
Sbjct: 117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFF 176

Query: 193 TLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGW 252
               +D+I  T  G N+ + +N    +++ + ++ ++ F     P+L L   +      +
Sbjct: 177 GAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLD---PFLLLISLFPFLTPVF 233

Query: 253 EHKK----SLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTD 308
           E          + H   NS+  ER  E                 K+K++  +D    + D
Sbjct: 234 EALNIGLFPKDVTHFLKNSI--ERMKESRL--------------KDKQKHRVDFFQQMID 277

Query: 309 DEGNR-------LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDD 361
            + ++       LS  ++  +    +F  +DTT+  + + +Y L ++P+VQ+K+  E+D 
Sbjct: 278 SQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDA 337

Query: 362 VFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVI 421
           V   +  P T + L ++ YL+ V+ ETLRLFP V    R   +D E+ G  + KG   ++
Sbjct: 338 VL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMV 396

Query: 422 IPYALHRDPRYFPNPEEFQPE-RFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTI 480
             YALH DP+Y+  PE+F PE RF  +N      Y Y+PF AGPRNCIG +FA+   K  
Sbjct: 397 PIYALHHDPKYWTEPEKFCPESRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLA 456

Query: 481 LSCILRHFWIESNQKRE-ELGLEGQLILRPSNGIWIKLKRRN 521
           +   L++F  +  ++ +  L L+   IL+P   I +K+  R+
Sbjct: 457 VIRALQNFSFKPCKETQIPLKLDNLPILQPEKPIVLKVHLRD 498


>gi|195972898 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  143 bits (361), Expect = 3e-34
 Identities = 131/544 (24%), Positives = 239/544 (43%), Gaps = 53/544 (9%)

Query: 12  KLLLWGAASALSLAGASLVLSLLQRVASYAR--KWQQMRPIPTVARAYPLVGHALLMKPD 69
           KL + G    ++L+ A L L      ++++R  K     P P+     P +G+    +  
Sbjct: 9   KLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPS-----PFIGNLTFFR-- 61

Query: 70  GREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLE- 128
            + F++  +E  + Y   PL   ++G    + +   + ++ +L  +     + M   LE 
Sbjct: 62  -QGFWESQMELRKLYG--PLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEF 118

Query: 129 PWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQ-EAFN 187
             +   +L     +W   R  L   F    L + + ++++  ++L+  L+++    +AF+
Sbjct: 119 KSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFD 178

Query: 188 CFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRR------IKMPWLWL 241
                     D++   A G  + +    +  +V+   R  E    R      +  P + +
Sbjct: 179 IQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMV 238

Query: 242 DLWYLMFKEGWEHKKSLQILHTFTNSVIAE--RANEMNANEDCRGD-------GRGSAPS 292
            L  ++        K+   L+ F N +I       +  A E+ R D        R SA  
Sbjct: 239 PLARIL------PNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASP 292

Query: 293 KNKRRAFLDLLLSVTDDEGNR---------------LSHEDIREEVDTFMFEGHDTTAAA 337
              +    D++  V    G +               L+ ++I  +   F+  G++     
Sbjct: 293 MGVQD--FDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNT 350

Query: 338 INWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL 397
           ++++ YLL +NP+ Q+K+  E+D    K   P      + L YL+ VI ETLR++P    
Sbjct: 351 LSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFR 410

Query: 398 FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAY 457
           F R  ++DCEV G R+  G    +   ALH DP ++P+PE F PERF  E  Q   P+ Y
Sbjct: 411 FTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTY 470

Query: 458 VPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIES-NQKREELGLEGQLILRPSNGIWIK 516
           +PF AGPR+C+G +  ++E K  L  +L  F  ++  + +  L LE +  L P NG++IK
Sbjct: 471 LPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIK 530

Query: 517 LKRR 520
           +  R
Sbjct: 531 IVSR 534


>gi|195972896 thromboxane A synthase 1, platelet isoform TXS-I [Homo
           sapiens]
          Length = 534

 Score =  143 bits (361), Expect = 3e-34
 Identities = 131/544 (24%), Positives = 239/544 (43%), Gaps = 53/544 (9%)

Query: 12  KLLLWGAASALSLAGASLVLSLLQRVASYAR--KWQQMRPIPTVARAYPLVGHALLMKPD 69
           KL + G    ++L+ A L L      ++++R  K     P P+     P +G+    +  
Sbjct: 9   KLEVNGPMVTVALSVALLALLKWYSTSAFSRLEKLGLRHPKPS-----PFIGNLTFFR-- 61

Query: 70  GREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLE- 128
            + F++  +E  + Y   PL   ++G    + +   + ++ +L  +     + M   LE 
Sbjct: 62  -QGFWESQMELRKLYG--PLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGLEF 118

Query: 129 PWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHINQ-EAFN 187
             +   +L     +W   R  L   F    L + + ++++  ++L+  L+++    +AF+
Sbjct: 119 KSVADSVLFLRDKRWEEVRGALMSAFSPEKLNEMVPLISQACDLLLAHLKRYAESGDAFD 178

Query: 188 CFFYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRR------IKMPWLWL 241
                     D++   A G  + +    +  +V+   R  E    R      +  P + +
Sbjct: 179 IQRCYCNYTTDVVASVAFGTPVDSWQAPEDPFVKHCKRFFEFCIPRPILVLLLSFPSIMV 238

Query: 242 DLWYLMFKEGWEHKKSLQILHTFTNSVIAE--RANEMNANEDCRGD-------GRGSAPS 292
            L  ++        K+   L+ F N +I       +  A E+ R D        R SA  
Sbjct: 239 PLARIL------PNKNRDELNGFFNKLIRNVIALRDQQAAEERRRDFLQMVLDARHSASP 292

Query: 293 KNKRRAFLDLLLSVTDDEGNR---------------LSHEDIREEVDTFMFEGHDTTAAA 337
              +    D++  V    G +               L+ ++I  +   F+  G++     
Sbjct: 293 MGVQD--FDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAFIFLIAGYEIITNT 350

Query: 338 INWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL 397
           ++++ YLL +NP+ Q+K+  E+D    K   P      + L YL+ VI ETLR++P    
Sbjct: 351 LSFATYLLATNPDCQEKLLREVDVFKEKHMAPEFCSLEEGLPYLDMVIAETLRMYPPAFR 410

Query: 398 FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAY 457
           F R  ++DCEV G R+  G    +   ALH DP ++P+PE F PERF  E  Q   P+ Y
Sbjct: 411 FTREAAQDCEVLGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQHRPFTY 470

Query: 458 VPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIES-NQKREELGLEGQLILRPSNGIWIK 516
           +PF AGPR+C+G +  ++E K  L  +L  F  ++  + +  L LE +  L P NG++IK
Sbjct: 471 LPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYIK 530

Query: 517 LKRR 520
           +  R
Sbjct: 531 IVSR 534


>gi|5729796 cytochrome P450, family 46 [Homo sapiens]
          Length = 500

 Score =  142 bits (359), Expect = 6e-34
 Identities = 137/512 (26%), Positives = 229/512 (44%), Gaps = 40/512 (7%)

Query: 22  LSLAGASLVLSLLQRVASYARKWQQMRPIPTVARAYPLVGHA-LLMKPD---GREFFQQI 77
           L L G++++L+         R   +   IP   R   L+GH     K D   GR      
Sbjct: 5   LLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVF 64

Query: 78  IEYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFL-----EPWLG 132
           +++ ++Y   P++++ V     V + + E+V+  L S+K    S MY+ L     E   G
Sbjct: 65  LDWAKKYG--PVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFG 122

Query: 133 LGLLTSTG-NKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLE-KHINQEAFNCFF 190
            GL++     +W  +R+++   F  + L   ++  NE+A  LV+ LE K   Q   +   
Sbjct: 123 QGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQD 182

Query: 191 YITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKE 250
            +T  A+DI+ + A G              +AV  M E I         +L       K+
Sbjct: 183 MLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLP---GKRKQ 239

Query: 251 GWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDE 310
             E ++S++ L       +  R   +   E+                   D+L  +   E
Sbjct: 240 LREVRESIRFLRQVGRDWVQRRREALKRGEEVPA----------------DILTQILKAE 283

Query: 311 GNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPA 370
                 E + +   TF   GH+T+A  + +++  L   PE+  ++  E+D+V G S R  
Sbjct: 284 EGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIG-SKRYL 342

Query: 371 TVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDP 430
             EDL +L+YL  V+KE+LRL+P      R + E+  + G RV   T  +   Y + R  
Sbjct: 343 DFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMD 402

Query: 431 RYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILR--HF 488
            YF +P  F P+RF P   + R  + Y PFS G R+CIGQ+FA ME K +++ +L+   F
Sbjct: 403 TYFEDPLTFNPDRFGPGAPKPR--FTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEF 460

Query: 489 WIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
            +   Q+    GL+ Q  L+P + +   L+ R
Sbjct: 461 RLVPGQR---FGLQEQATLKPLDPVLCTLRPR 489


>gi|4503211 cytochrome P450, family 27, subfamily A, polypeptide 1
           precursor [Homo sapiens]
          Length = 531

 Score =  132 bits (331), Expect = 1e-30
 Identities = 115/469 (24%), Positives = 208/469 (44%), Gaps = 63/469 (13%)

Query: 85  RHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPW--------LGLGLL 136
           ++ P+   ++GP   V L +A  +E ++   +Q  K  +   +E W        L  G  
Sbjct: 91  KYGPMWMSYLGPQMHVNLASAPLLEQVM---RQEGKYPVRNDMELWKEHRDQHDLTYGPF 147

Query: 137 TSTGNKWRSRRKML-------------TPTFHFTILEDFLDIMNEQANILVKKLEKHINQ 183
           T+ G+ W   R+ L             T  F+  +++DF+  +++   +  +    +   
Sbjct: 148 TTEGHHWYQLRQALNQRLLKPAEAALYTDAFN-EVIDDFMTRLDQ---LRAESASGNQVS 203

Query: 184 EAFNCFFYITLCALDIICETAMGKNIGAQSN----DDSEYVRAVYRMSEMIFRRIKMPWL 239
           +    F+Y    AL+ IC     K IG        D   +VR++  M +       +P  
Sbjct: 204 DMAQLFYYF---ALEAICYILFEKRIGCLQRSIPEDTVTFVRSIGLMFQNSLYATFLP-K 259

Query: 240 W----LDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNK 295
           W    L  W   + +GW        + +F   +I E+  +M A     G      P   +
Sbjct: 260 WTRPVLPFWK-RYLDGWN------AIFSFGKKLIDEKLEDMEAQLQAAG------PDGIQ 306

Query: 296 RRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKV 355
              +L  LL+       +LS  +    +   +  G DTT+  + W+LY L  +PE+Q+ +
Sbjct: 307 VSGYLHFLLA-----SGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEAL 361

Query: 356 DHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLK 415
             E+  V      P   +D   +  L+ V+KETLRL+P VP  +R + ++ EV G+   K
Sbjct: 362 HEEVVGVVPAGQVPQH-KDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVDGFLFPK 420

Query: 416 GTEAVIIPYALHRDPRYFPNPEEFQPERFF----PENAQGRHPYAYVPFSAGPRNCIGQK 471
            T+ V   Y + RDP  F  PE FQP R+     P   + +HP+  VPF  G R C+G++
Sbjct: 421 NTQFVFCHYVVSRDPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRR 480

Query: 472 FAVMEEKTILSCILRHFWIESNQKREELGLEGQLILRPSNGIWIKLKRR 520
            A +E + +L+ +++ + +    +  EL    +++L P+  + ++  +R
Sbjct: 481 IAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQR 529


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  130 bits (327), Expect = 3e-30
 Identities = 121/470 (25%), Positives = 214/470 (45%), Gaps = 50/470 (10%)

Query: 44  WQQM---RPIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMV 100
           W+Q    R +P      P++G+ L +  D ++  +    +++ Y   P+  ++ G  P+V
Sbjct: 20  WRQSCRRRKLPPGPTPLPIIGNMLQI--DVKDICKSFTNFSKVYG--PVFTVYFGMNPIV 75

Query: 101 ALYNAENV-EVILTSSKQIDKSSMYKFLEPWL-GLGLLTSTGNKWRSRRKMLTPTFHFTI 158
             +  E V E ++ + ++          +    GLG+++S G +W+  R+     F  T 
Sbjct: 76  VFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRR-----FSLTT 130

Query: 159 LEDF-------LDIMNEQANILVKKLEKHINQEAFNC--FFYITLCALDIICETAMGKNI 209
           L +F        D + E+A+ LV++L K    +A  C   F +     ++IC     K  
Sbjct: 131 LRNFGMGKRSIEDRVQEEAHCLVEELRK---TKASPCDPTFILGCAPCNVICSVVFQKRF 187

Query: 210 GAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWE--HKKSLQILHTFTNS 267
             +   D  ++  + R +E  FR +  PW+ +   + +  + +   H K L+ +   T S
Sbjct: 188 DYK---DQNFLTLMKRFNEN-FRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNV-ALTRS 242

Query: 268 VIAERANEMNANEDCRGDGRGSAPSKNKRRAFLD-LLLSVTDDEGNRLSHEDIREEVDT- 325
            I E+  E  A+ D            N  R F+D  L+ +  ++ N+ S  +I   V T 
Sbjct: 243 YIREKVKEHQASLDV-----------NNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTV 291

Query: 326 --FMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLEC 383
                 G +TT+  + + L LL  +PEV  KV  E+D V G+   P  ++D   + Y + 
Sbjct: 292 ADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC-MQDRSHMPYTDA 350

Query: 384 VIKETLRLFPSVPL-FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPE 442
           V+ E  R    VP     +V+ D +   Y + KGT  + +  ++  D + FPNP  F P 
Sbjct: 351 VVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPG 410

Query: 443 RFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIES 492
            F  +N   +    ++PFSAG R C G+  A ME    L+ IL++F ++S
Sbjct: 411 HFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKS 460


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  127 bits (319), Expect = 2e-29
 Identities = 113/467 (24%), Positives = 204/467 (43%), Gaps = 35/467 (7%)

Query: 50  IPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENV- 108
           +P   R  PL+G+ L M  D R   +  + + E+Y  +  + L  GP P+V L   E + 
Sbjct: 30  LPPGPRPLPLLGNLLQM--DRRGLLKSFLRFREKYGDVFTVHL--GPRPVVMLCGVEAIR 85

Query: 109 EVILTSSKQIDKSSMYKFLEPWL-GLGLLTSTGNKWRSRRKMLTPTFHFTILEDF----- 162
           E ++  ++          ++P+  G G++ + GN+W+  R+     F  T + DF     
Sbjct: 86  EALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRR-----FSVTTMRDFGMGKR 140

Query: 163 --LDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYV 220
              + + E+A  L+++L K         F + ++ A +IIC    GK    Q  +  + +
Sbjct: 141 SVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITA-NIICSIVFGKRFHYQDQEFLKML 199

Query: 221 RAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWEHK--KSLQILHTFTNSVIAERANEMNA 278
              Y+   +I   +      L   +L +  G   +  K+LQ ++ +    + +    ++ 
Sbjct: 200 NLFYQTFSLI-SSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDP 258

Query: 279 NEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAAI 338
                     SAP K+    +L  +     +  +  SH+++     +  F G +TT+  +
Sbjct: 259 ----------SAP-KDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTL 307

Query: 339 NWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL- 397
            +   L+   P V ++V  E++ V G   RP  + D  K+ Y E VI E  R    +P+ 
Sbjct: 308 RYGFLLMLKYPHVAERVYREIEQVIGPH-RPPELHDRAKMPYTEAVIYEIQRFSDLLPMG 366

Query: 398 FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAY 457
               V++     GY + K TE  +I      DP YF  P+ F P+ F   N   +   A+
Sbjct: 367 VPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAF 426

Query: 458 VPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGLEGQ 504
           +PFS G R C+G+  A  E     + IL++F + S    E++ L  Q
Sbjct: 427 IPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQ 473


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  124 bits (312), Expect = 2e-28
 Identities = 124/500 (24%), Positives = 224/500 (44%), Gaps = 54/500 (10%)

Query: 24  LAGASLVLSLLQ--RVASYARKWQQMRP---IPTVARAYPLVGHALLMKPDGREFFQQII 78
           LA   L+++LL    V      WQQ +    +P      P +G+ L +  +  + +  ++
Sbjct: 2   LASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTE--QMYNSLM 59

Query: 79  EYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWL--GLGLL 136
           + +E Y   P+  + +GP  +V L   + V   L    +       +    W+  G G++
Sbjct: 60  KISERYG--PVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVV 117

Query: 137 TSTGNKWRSRRKMLTPTFHFTILEDF-------LDIMNEQANILVKKLEKHINQEAFNCF 189
            S G + +  R+     F    L DF        + + E+A  L+  L +       +  
Sbjct: 118 FSNGERAKQLRR-----FSIATLRDFGVGKRGIEERIQEEAGFLIDAL-RGTGGANIDPT 171

Query: 190 FYITLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFK 249
           F+++    ++I     G     +   D E++ ++ RM   IF+        L   Y MF 
Sbjct: 172 FFLSRTVSNVISSIVFGDRFDYK---DKEFL-SLLRMMLGIFQFTSTSTGQL---YEMFS 224

Query: 250 EGWEH-----KKSLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLD-LL 303
              +H     +++ Q+L    +  IA++        D            N  R F+D  L
Sbjct: 225 SVMKHLPGPQQQAFQLLQGLED-FIAKKVEHNQRTLD-----------PNSPRDFIDSFL 272

Query: 304 LSVTDDEGNRLSHEDIREEVDTFM---FEGHDTTAAAINWSLYLLGSNPEVQKKVDHELD 360
           + + ++E N  +   ++  V T +     G +T +  + +   LL  +PEV+ KV  E+D
Sbjct: 273 IRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEID 332

Query: 361 DVFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPL-FARSVSEDCEVAGYRVLKGTEA 419
            V GK+ +P   ED  K+ Y+E VI E  R    +P+  AR V +D +   + + KGTE 
Sbjct: 333 RVIGKNRQPK-FEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEV 391

Query: 420 VIIPYALHRDPRYFPNPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKT 479
             +  ++ RDP +F NP++F P+ F  E  Q +   A+VPFS G RNC G+  A ME   
Sbjct: 392 YPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFL 451

Query: 480 ILSCILRHFWIESNQKREEL 499
             + ++++F ++S+Q  +++
Sbjct: 452 FFTTVMQNFRLKSSQSPKDI 471


>gi|16933530 cytochrome P450, family 26, subfamily A, polypeptide 1
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  122 bits (307), Expect = 6e-28
 Identities = 114/454 (25%), Positives = 194/454 (42%), Gaps = 49/454 (10%)

Query: 49  PIPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENV 108
           P+P     +P  G  L M    R+F Q      +  ++  + K  +   P V +  A+NV
Sbjct: 43  PLPPGTMGFPFFGETLQMVLQRRKFLQM-----KRRKYGFIYKTHLFGRPTVRVMGADNV 97

Query: 109 EVILTSSKQIDKSSMYKFLEPWLGLGLLTST-GNKWRSRRKMLTPTFHFTILEDFLDIMN 167
             IL    ++        +   LG G L++   +  + R+K++   F    LE ++ ++ 
Sbjct: 98  RRILLGEHRLVSVHWPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVIT 157

Query: 168 EQANILVKKLEKHIN---------QEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSE 218
           E+       LE+ ++          E     F I +  L + CE      +    + + +
Sbjct: 158 EEVG---SSLEQWLSCGERGLLVYPEVKRLMFRIAMRIL-LGCEP----QLAGDGDSEQQ 209

Query: 219 YVRAVYRMSEMIFRR-IKMPWLWLDLWYLMFKEGWEHKKSLQILHTFTNSVIAERANEMN 277
            V A   M+  +F   I +P+  L          +   K+  ++H      I  +   + 
Sbjct: 210 LVEAFEEMTRNLFSLPIDVPFSGL----------YRGMKARNLIHARIEQNIRAKICGLR 259

Query: 278 ANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDIREEVDTFMFEGHDTTAAA 337
           A+E   G G   A         L LL+  + + G RL  + +++     +F GH+TTA+A
Sbjct: 260 ASE--AGQGCKDA---------LQLLIEHSWERGERLDMQALKQSSTELLFGGHETTASA 308

Query: 338 INWSLYLLGSNPEVQKKVDHELDD----VFGKSDRPATVEDLKKLRYLECVIKETLRLFP 393
               +  LG  P V +KV  EL           D    +E L++L+Y+ CVIKETLRL P
Sbjct: 309 ATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNP 368

Query: 394 SVPLFARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRH 453
            VP   R   +  E+ GY++ KG   +      H     F N EEF P+RF   + +   
Sbjct: 369 PVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDAS 428

Query: 454 PYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRH 487
            ++++PF  G R+C+G++FA +  K     + RH
Sbjct: 429 RFSFIPFGGGLRSCVGKEFAKILLKIFTVELARH 462


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  120 bits (301), Expect = 3e-27
 Identities = 106/418 (25%), Positives = 189/418 (45%), Gaps = 33/418 (7%)

Query: 88  PLLKLWVGPVPMVALYNAENV-EVILTSSKQIDKSSMYKFLEPW-LGLGLLTSTGNKWRS 145
           P+  L+ G  P+V L+  E V E ++   ++     ++   E    G G++ S G KW+ 
Sbjct: 63  PVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKE 122

Query: 146 RRKMLTPTFHFTIL--EDFLDIMNEQANILVKKLEKHINQEAFNC--FFYITLCALDIIC 201
            R+    T     +      D + E+A  LV++L K    +A  C   F +     ++IC
Sbjct: 123 IRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRK---TKASPCDPTFILGCAPCNVIC 179

Query: 202 ETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGWE--HKKSLQ 259
                K    +   D +++  + +++E I + +  PW+ +   +    + +   H K L+
Sbjct: 180 SIIFHKRFDYK---DQQFLNLMEKLNENI-KILSSPWIQICNNFSPIIDYFPGTHNKLLK 235

Query: 260 ILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTDDEGNRLSHEDI 319
            +  F  S I E+  E   + D            N  + F+D  L   + E +    E  
Sbjct: 236 NV-AFMKSYILEKVKEHQESMDM-----------NNPQDFIDCFLMKMEKEKHNQPSEFT 283

Query: 320 REEVDTFMFE----GHDTTAAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDL 375
            E ++    +    G +TT+  + ++L LL  +PEV  KV  E++ V G++  P  ++D 
Sbjct: 284 IESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPC-MQDR 342

Query: 376 KKLRYLECVIKETLRLFPSVPL-FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFP 434
             + Y + V+ E  R    +P     +V+ D +   Y + KGT  +I   ++  D + FP
Sbjct: 343 SHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFP 402

Query: 435 NPEEFQPERFFPENAQGRHPYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIES 492
           NPE F P  F  E    +    ++PFSAG R C+G+  A ME    L+ IL++F ++S
Sbjct: 403 NPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKS 460


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  120 bits (301), Expect = 3e-27
 Identities = 113/468 (24%), Positives = 205/468 (43%), Gaps = 43/468 (9%)

Query: 50  IPTVARAYPLVGHALLMKPDGREFFQQIIEYTEEYRHMPLLKLWVGPVPMVALYNAENVE 109
           +P   R   ++G+ LL+    ++    + + ++EY  M  + L    V +++ Y A    
Sbjct: 30  LPPGPRPLSILGNLLLLC--SQDMLTSLTKLSKEYGSMYTVHLGPRRVVVLSGYQAVKEA 87

Query: 110 VILTSSKQIDKSSMYKFLEPWLGLGLLTSTGNKWRSRRKMLTPTFHFTILEDF------- 162
           ++    +   +     F     G G+  S+G++W+  R+     F   IL +F       
Sbjct: 88  LVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQ-----FSIQILRNFGMGKRSI 142

Query: 163 LDIMNEQANILVKKLEKHINQEAFNCFFYITLCALDIICETAMGKNIGAQSNDDSEYVRA 222
            + + E+ + L+ +L K    E F+  F ++    +IIC    G       + D E +  
Sbjct: 143 EERILEEGSFLLAELRK-TEGEPFDPTFVLSRSVSNIICSVLFGSRF----DYDDERLLT 197

Query: 223 VYRMSEMIFRRIKMPWLWLDLWYLMFKE--GWEHKKSLQILHTFT--NSVIAERANEMNA 278
           + R+    F+ +  PW  L   Y +F     W      +I   F     +IA   ++  A
Sbjct: 198 IIRLINDNFQIMSSPWGEL---YDIFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQA 254

Query: 279 NEDCRGDGRGSAPSKNKRRAFLDLLLS-VTDDEGNRLSH---EDIREEVDTFMFEGHDTT 334
           + D R             R F+   L+ + +++ + LSH   + +       +F G  T 
Sbjct: 255 SLDPRSP-----------RDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTV 303

Query: 335 AAAINWSLYLLGSNPEVQKKVDHELDDVFGKSDRPATVEDLKKLRYLECVIKETLRLFPS 394
           +  ++ +   L   P+VQ +V  E+D V G++  PA ++D   + Y + VI E  R    
Sbjct: 304 STTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPA-LKDRAAMPYTDAVIHEVQRFADI 362

Query: 395 VPL-FARSVSEDCEVAGYRVLKGTEAVIIPYALHRDPRYFPNPEEFQPERFFPENAQGRH 453
           +P+     V+ D    G+ + KGT+ + +   +H DP  F  P+EF PE F   N   + 
Sbjct: 363 IPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKK 422

Query: 454 PYAYVPFSAGPRNCIGQKFAVMEEKTILSCILRHFWIESNQKREELGL 501
             A++PFSAG R C+G+  A ME    L+ IL+ F ++     E++ L
Sbjct: 423 SPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDL 470


>gi|16933535 cytochrome P450, family 3, subfamily A, polypeptide 43
           isoform 3 [Homo sapiens]
          Length = 420

 Score =  120 bits (300), Expect = 4e-27
 Identities = 94/382 (24%), Positives = 179/382 (46%), Gaps = 43/382 (11%)

Query: 79  EYTEEYRHMPLLKLWVGPVPMVALYNAENVEVILTSSKQIDKSSMYKFLEPWLGLGLLTS 138
           E  E+Y  M    L+ G  PM+ + + + ++ +L      +  S++    P   +G L S
Sbjct: 63  ECNEKYGEM--WGLYEGQQPMLVIMDPDMIKTVLVK----ECYSVFTNQMPLGPMGFLKS 116

Query: 139 T-----GNKWRSRRKMLTPTFHFTILEDFLDIMNEQANILVKKLEKHI-NQEAFNCFFYI 192
                   +W+  R +L+P F     ++ + I+++  ++LV+ L +   N ++ N   + 
Sbjct: 117 ALSFAEDEEWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFF 176

Query: 193 TLCALDIICETAMGKNIGAQSNDDSEYVRAVYRMSEMIFRRIKMPWLWLDLWYLMFKEGW 252
               +D+I  T  G N+ + +N    +++ + ++ ++ F     P+L L   +      +
Sbjct: 177 GAYTMDVITGTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLD---PFLLLISLFPFLTPVF 233

Query: 253 EHKK----SLQILHTFTNSVIAERANEMNANEDCRGDGRGSAPSKNKRRAFLDLLLSVTD 308
           E          + H   NS+  ER  E                 K+K++  +D    + D
Sbjct: 234 EALNIGLFPKDVTHFLKNSI--ERMKESRL--------------KDKQKHRVDFFQQMID 277

Query: 309 DEGNR-------LSHEDIREEVDTFMFEGHDTTAAAINWSLYLLGSNPEVQKKVDHELDD 361
            + ++       LS  ++  +    +F  +DTT+  + + +Y L ++P+VQ+K+  E+D 
Sbjct: 278 SQNSKETKSHKALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDA 337

Query: 362 VFGKSDRPATVEDLKKLRYLECVIKETLRLFPSVPLFARSVSEDCEVAGYRVLKGTEAVI 421
           V   +  P T + L ++ YL+ V+ ETLRLFP V    R   +D E+ G  + KG   ++
Sbjct: 338 VL-PNKAPVTYDALVQMEYLDMVVNETLRLFPVVSRVTRVCKKDIEINGVFIPKGLAVMV 396

Query: 422 IPYALHRDPRYFPNPEEFQPER 443
             YALH DP+Y+  PE+F PER
Sbjct: 397 PIYALHHDPKYWTEPEKFCPER 418


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,203,694
Number of Sequences: 37866
Number of extensions: 890881
Number of successful extensions: 2121
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 73
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 1874
Number of HSP's gapped (non-prelim): 90
length of query: 525
length of database: 18,247,518
effective HSP length: 107
effective length of query: 418
effective length of database: 14,195,856
effective search space: 5933867808
effective search space used: 5933867808
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.