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Search of human proteins with 187828564
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187828564 BEN domain containing 5 [Homo sapiens]
(421 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187828564 BEN domain containing 5 [Homo sapiens] 843 0.0
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 44 2e-04
gi|45439327 periplakin [Homo sapiens] 44 3e-04
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 43 6e-04
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 43 6e-04
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 42 8e-04
gi|239748549 PREDICTED: hypothetical protein LOC100129791 [Homo ... 42 0.001
gi|239742533 PREDICTED: hypothetical protein LOC100129791 [Homo ... 42 0.001
gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta ... 41 0.002
gi|31542634 filamin A interacting protein 1 [Homo sapiens] 40 0.003
gi|239754018 PREDICTED: hypothetical protein LOC100129791 [Homo ... 40 0.004
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 40 0.005
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 40 0.005
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 40 0.005
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 40 0.005
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 40 0.005
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 40 0.005
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 40 0.005
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 40 0.005
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 39 0.007
gi|21735548 centrosomal protein 2 [Homo sapiens] 39 0.012
gi|239787821 syncoilin, intermediate filament 1 isoform 2 [Homo ... 38 0.015
gi|166706887 syncoilin, intermediate filament 1 isoform 1 [Homo ... 38 0.015
gi|58530840 desmoplakin isoform I [Homo sapiens] 38 0.015
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 38 0.015
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 37 0.026
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 37 0.026
gi|16262452 cingulin [Homo sapiens] 37 0.034
gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo s... 37 0.034
gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo... 37 0.044
>gi|187828564 BEN domain containing 5 [Homo sapiens]
Length = 421
Score = 843 bits (2178), Expect = 0.0
Identities = 421/421 (100%), Positives = 421/421 (100%)
Query: 1 MYAFVRFLEDNVCYALPVSCVRDFSPRSRLDFDNQKVYAVYRGPEELGAGPESPPRAPRD 60
MYAFVRFLEDNVCYALPVSCVRDFSPRSRLDFDNQKVYAVYRGPEELGAGPESPPRAPRD
Sbjct: 1 MYAFVRFLEDNVCYALPVSCVRDFSPRSRLDFDNQKVYAVYRGPEELGAGPESPPRAPRD 60
Query: 61 WGALLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIK 120
WGALLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIK
Sbjct: 61 WGALLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIK 120
Query: 121 RPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPR 180
RPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPR
Sbjct: 121 RPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPR 180
Query: 181 ALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMKELRDLNRRLQD 240
ALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMKELRDLNRRLQD
Sbjct: 181 ALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMKELRDLNRRLQD 240
Query: 241 VLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSEEANTSSYYPAPAPVMDKYILDNGKVH 300
VLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSEEANTSSYYPAPAPVMDKYILDNGKVH
Sbjct: 241 VLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSEEANTSSYYPAPAPVMDKYILDNGKVH 300
Query: 301 LGSGIWVDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTGVATKKKKDAVPKPPL 360
LGSGIWVDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTGVATKKKKDAVPKPPL
Sbjct: 301 LGSGIWVDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTGVATKKKKDAVPKPPL 360
Query: 361 SPHKLSIVRECLYDRIAQETVDETEIAQRLSKVNKYICEKIMDINKSCKNEERREAKYNL 420
SPHKLSIVRECLYDRIAQETVDETEIAQRLSKVNKYICEKIMDINKSCKNEERREAKYNL
Sbjct: 361 SPHKLSIVRECLYDRIAQETVDETEIAQRLSKVNKYICEKIMDINKSCKNEERREAKYNL 420
Query: 421 Q 421
Q
Sbjct: 421 Q 421
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 44.3 bits (103), Expect = 2e-04
Identities = 54/216 (25%), Positives = 96/216 (44%), Gaps = 34/216 (15%)
Query: 72 LALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKPSEVA 131
LA+A+ K+D + ++ IP + ++E GE +L+ ++R R E
Sbjct: 372 LAMAQQKADTASDTKGRQEPIPSDAAQEMQELGE---------KLQALERE--RTKVEEV 420
Query: 132 HKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDS-----------LEDAVVPR 180
++ A + +L K+ L E + E +P E++ L++ +
Sbjct: 421 NRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHT 480
Query: 181 ALYEE----LLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMKE-----L 231
+ +EE L R +QQQEE L+QE+ RQL +L + VS+++E +
Sbjct: 481 SSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLI 540
Query: 232 RDLNRRLQDV-LLLRLGS--GPAIDLEKVKSECLEP 264
+D + Q V +L RL GP + + K+E L P
Sbjct: 541 QDKDHLSQQVGMLERLAGPPGPELPVAGEKNEALVP 576
Score = 30.4 bits (67), Expect = 3.1
Identities = 41/214 (19%), Positives = 86/214 (40%), Gaps = 22/214 (10%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKP 127
+A +LA+ + K ++ + +K+ + ++GE + EE Q + +
Sbjct: 678 EASLLAVRKAKEAMKAQMAEKEAILQS-------KEGECQQLREEVEQCQQL-------- 722
Query: 128 SEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEELL 187
+E H+ + A+ ++ ++Q L + + V E + + +A E
Sbjct: 723 AEARHRELRALESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELAAQLALSQAQLEVHQ 782
Query: 188 RNYQQQQEEMRHLQQEL-------ERTRRQLVQQAKKLKEYGALVSEMKELRDLNRRLQD 240
Q+ Q ++ LQ ++ ++ + QL L+E+ LV ++KE + R
Sbjct: 783 GEVQRLQAQVVDLQAKMRAALDDQDKVQSQLSMAEAVLREHKTLVQQLKEQNEALNRAHV 842
Query: 241 VLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSE 274
LL+ E+ E + E ELR+ E
Sbjct: 843 QELLQCSEREGALQEERADEAQQREEELRALQEE 876
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 43.9 bits (102), Expect = 3e-04
Identities = 61/235 (25%), Positives = 105/235 (44%), Gaps = 51/235 (21%)
Query: 64 LLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPE 123
+LL + ++ ALAE+KS + V +K ++ KL N + + E + LQ H ++ +
Sbjct: 1031 VLLLQQRVAALAEEKSRAQEKVTEK--EVVKLQ-NDPQLEAEY-----QQLQEDHQRQDQ 1082
Query: 124 GRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTE-DMDSL-----EDAV 177
R+ E ++ + RLEK+ ++ G T E + VE TE ++ L ++A
Sbjct: 1083 LREKQEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAA 1142
Query: 178 VPRALYE---ELLRNYQQQQEEMRHL----------------QQELERTRRQLVQQAKKL 218
RA ELLR +EE + + E+ R +LV+Q +K
Sbjct: 1143 KARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKY 1202
Query: 219 KEYGA---LVSEMKELRDLNRRLQDVLLLRLGSGPAIDLEKVKSECL--EPEPEL 268
+ GA L S EL L RR GP +++++V E + + +PE+
Sbjct: 1203 R--GAEEQLRSYQSELEALRRR-----------GPQVEVKEVTKEVIKYKTDPEM 1244
Score = 29.3 bits (64), Expect = 7.0
Identities = 46/202 (22%), Positives = 77/202 (38%), Gaps = 24/202 (11%)
Query: 87 QKKIKIPKLSLNHVEEDGEVKDYGEEDL-QLRHIKRPEGRKPSEVAHKSIEAVVARLEKQ 145
Q K ++ L EE + D E Q I R E + S V + ++ V R E++
Sbjct: 1303 QTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKE-EELSRVKERVVQQEVVRYEEE 1361
Query: 146 NGLSLGHSTCPEEVFVEASP--------------GTEDMDSLEDAVVPRALYEELLRNYQ 191
GL S E + VE TE LE+ R E R Q
Sbjct: 1362 PGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELERERQARREAEREVQ 1421
Query: 192 QQQEEMRHLQQELERTRRQ--------LVQQAKKLKEYGALVSEMKELRDLNRRLQDVLL 243
+ Q+ + L+QE R + L Q ++ +E+ L +++E + + L+ L
Sbjct: 1422 RLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRLQLEEEQHRRQLLEGELE 1481
Query: 244 LRLGSGPAIDLEKVKSECLEPE 265
A++ +VK + + E
Sbjct: 1482 TLRRKLAALEKAEVKEKVVLSE 1503
Score = 28.9 bits (63), Expect = 9.2
Identities = 36/171 (21%), Positives = 81/171 (47%), Gaps = 16/171 (9%)
Query: 84 SVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKPSEVAHKSIEAVVARLE 143
++ +++++ + +LN + + EV + E LQ RP+ E A K + + E
Sbjct: 851 AINRQRLQNLEFALNLLRQQPEV-EVTHETLQRN---RPDSGV--EEAWKIRKELDEETE 904
Query: 144 KQNGLSLGHSTCPEEVFVEASPGTED-------MDSLEDAVVPRALYEELLRNYQQQQEE 196
++ L + EE++ + G ++ + + D V+ + +++L R ++Q +
Sbjct: 905 RRRQLENEVKSTQEEIWTLRNQGPQESVVRKEVLKKVPDPVLEES-FQQLQRTLAEEQHK 963
Query: 197 MRHLQQELERTRRQLVQQAKKLKEYGA--LVSEMKELRDLNRRLQDVLLLR 245
+ LQ+ELE + QL ++ ++ G +V E+ + + +VL LR
Sbjct: 964 NQLLQEELEALQLQLRALEQETRDGGQEYVVKEVLRIEPDRAQADEVLQLR 1014
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 42.7 bits (99), Expect = 6e-04
Identities = 83/374 (22%), Positives = 157/374 (41%), Gaps = 49/374 (13%)
Query: 65 LLHKAQILA--LAEDKSDLEN------SVMQKKIKIPKLSLNHVEEDGE--VKDYGEEDL 114
L K +IL + ++K L+N +M++K ++ K ++ + E+ E +K +E+
Sbjct: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK-TIETLRENSERQIKILEQENE 561
Query: 115 QLRHIKRPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLE 174
L R+ S++ S EA V +EK+N + E E S ++ E
Sbjct: 562 HLNQTVSSL-RQRSQI---SAEARVKDIEKENKIL-------HESIKETSSKLSKIE-FE 609
Query: 175 DAVVPRAL--YEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMKELR 232
+ + L Y+E ++ + E+ HL++E E ++++ ++ AL E EL
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE 669
Query: 233 DLNRRLQDVL-LLRLGSGPAIDLEKVKSECLEPEPELRSTFSEEANTSSYYPAPAPVMDK 291
NR+L+ L + + LEK S+ E ELR E +S A + +K
Sbjct: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV-ESLKCASMKMAQLQLENK 728
Query: 292 YILDNGKVHLGSGIWVDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTGVATKKK 351
L++ K L G L++ + K T+ L V G D+ R + K
Sbjct: 729 E-LESEKEQLKKG----------LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNK 777
Query: 352 KDAVPKPPLSPHKLSIVRECLYDRIAQETVDETEIA----QRLSKVNKYICEKIMDINKS 407
K + L ++ ++ Q+ ++E +I+ ++L K NK + ++ + K
Sbjct: 778 KIQQLESELQDLEME-------NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830
Query: 408 CKNEERREAKYNLQ 421
K E+ + Q
Sbjct: 831 KKQLEKENKRLRQQ 844
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 42.7 bits (99), Expect = 6e-04
Identities = 83/374 (22%), Positives = 157/374 (41%), Gaps = 49/374 (13%)
Query: 65 LLHKAQILA--LAEDKSDLEN------SVMQKKIKIPKLSLNHVEEDGE--VKDYGEEDL 114
L K +IL + ++K L+N +M++K ++ K ++ + E+ E +K +E+
Sbjct: 503 LSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEK-TIETLRENSERQIKILEQENE 561
Query: 115 QLRHIKRPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLE 174
L R+ S++ S EA V +EK+N + E E S ++ E
Sbjct: 562 HLNQTVSSL-RQRSQI---SAEARVKDIEKENKIL-------HESIKETSSKLSKIE-FE 609
Query: 175 DAVVPRAL--YEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMKELR 232
+ + L Y+E ++ + E+ HL++E E ++++ ++ AL E EL
Sbjct: 610 KRQIKKELEHYKEKGERAEELENELHHLEKENELLQKKITNLKITCEKIEALEQENSELE 669
Query: 233 DLNRRLQDVL-LLRLGSGPAIDLEKVKSECLEPEPELRSTFSEEANTSSYYPAPAPVMDK 291
NR+L+ L + + LEK S+ E ELR E +S A + +K
Sbjct: 670 RENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNV-ESLKCASMKMAQLQLENK 728
Query: 292 YILDNGKVHLGSGIWVDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTGVATKKK 351
L++ K L G L++ + K T+ L V G D+ R + K
Sbjct: 729 E-LESEKEQLKKG----------LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNK 777
Query: 352 KDAVPKPPLSPHKLSIVRECLYDRIAQETVDETEIA----QRLSKVNKYICEKIMDINKS 407
K + L ++ ++ Q+ ++E +I+ ++L K NK + ++ + K
Sbjct: 778 KIQQLESELQDLEME-------NQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKD 830
Query: 408 CKNEERREAKYNLQ 421
K E+ + Q
Sbjct: 831 KKQLEKENKRLRQQ 844
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 42.4 bits (98), Expect = 8e-04
Identities = 40/156 (25%), Positives = 74/156 (47%), Gaps = 19/156 (12%)
Query: 100 VEEDGEVKDYGEEDLQLRHIKRPEGRKPSEVAHKSIEAVVAR-LEKQNGLSLGHSTCPEE 158
+E + +K ++D+++ +K+ + + HK + V++ LE+Q L+ +E
Sbjct: 759 LEHEHLIKLNQKKDMEIAELKK--NIEQMDTDHKETKDVLSSSLEEQKQLT--QLINKKE 814
Query: 159 VFVE-----ASPGTEDMDSLEDAV----VPRALYEELLRNYQQQQEEMRHLQQELERTRR 209
+F+E +S E++D A+ + R EE R+ +EE HLQ+ELER R
Sbjct: 815 IFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLRE 874
Query: 210 QL-----VQQAKKLKEYGALVSEMKELRDLNRRLQD 240
+ V K L L SE+ +L + L++
Sbjct: 875 EQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEE 910
Score = 32.0 bits (71), Expect = 1.1
Identities = 42/209 (20%), Positives = 91/209 (43%), Gaps = 11/209 (5%)
Query: 60 DWGALLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHI 119
D+G ++ + +I L+ + S LE+ V + I + S ++ + + + ++ +
Sbjct: 163 DFGDIISSQQEINRLSNEVSRLESEVGHWR-HIAQTSKAQGTDNSDQSEICKLQNIIKEL 221
Query: 120 KRPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVP 179
K+ ++ + H+ A +K +S H E S E ++ LE+ +
Sbjct: 222 KQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHRE-------ELSDYEERIEELENLLQQ 274
Query: 180 --RALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMKELRDLNRR 237
+ E L + Q+ ++ LQ E + +++ Q K+K+ +S + RD+ RR
Sbjct: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
Query: 238 LQDVLLLRLGSGPAIDLEKVKSECLEPEP 266
Q+ L + + E +K EC + +P
Sbjct: 335 EQEQLNVEKRQ-IMEECENLKLECSKLQP 362
Score = 28.9 bits (63), Expect = 9.2
Identities = 45/180 (25%), Positives = 75/180 (41%), Gaps = 27/180 (15%)
Query: 74 LAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKPSEVAHK 133
L E+ L+ V+ KL +++ G ++ Y + + +L++ G++ ++V H
Sbjct: 1242 LQEELHQLQAQVLVDSDNNSKLQVDYT---GLIQSYEQNETKLKNF----GQELAQVQHS 1294
Query: 134 SIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYE--ELLRNYQ 191
+ +L L LG AS T A L E ELL Q
Sbjct: 1295 -----IGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELL---Q 1346
Query: 192 QQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMK---------ELRDLNRRLQDVL 242
Q+ EE+R QE + T R L + +L + A SE++ E++ L + QDVL
Sbjct: 1347 QELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEK-QDVL 1405
>gi|239748549 PREDICTED: hypothetical protein LOC100129791 [Homo
sapiens]
Length = 338
Score = 41.6 bits (96), Expect = 0.001
Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 6/102 (5%)
Query: 144 KQNGLSLGHSTCPEEVFVEASPGTE------DMDSLEDAVVPRALYEELLRNYQQQQEEM 197
++ G S S P +SP TE D D L +A R+ Y EL + Q + +++
Sbjct: 7 RKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTKGKKV 66
Query: 198 RHLQQELERTRRQLVQQAKKLKEYGALVSEMKELRDLNRRLQ 239
+ ++ LE ++ K LKE L ++ +ELR+ R L+
Sbjct: 67 ENFEKNLEECITRITNTEKCLKELMELKTKARELREECRSLR 108
>gi|239742533 PREDICTED: hypothetical protein LOC100129791 [Homo
sapiens]
Length = 338
Score = 41.6 bits (96), Expect = 0.001
Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 6/102 (5%)
Query: 144 KQNGLSLGHSTCPEEVFVEASPGTE------DMDSLEDAVVPRALYEELLRNYQQQQEEM 197
++ G S S P +SP TE D D L +A R+ Y EL + Q + +++
Sbjct: 7 RKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTKGKKV 66
Query: 198 RHLQQELERTRRQLVQQAKKLKEYGALVSEMKELRDLNRRLQ 239
+ ++ LE ++ K LKE L ++ +ELR+ R L+
Sbjct: 67 ENFEKNLEECITRITNTEKCLKELMELKTKARELREECRSLR 108
>gi|114842389 myosin, heavy polypeptide 7B, cardiac muscle, beta [Homo
sapiens]
Length = 1983
Score = 40.8 bits (94), Expect = 0.002
Identities = 42/172 (24%), Positives = 72/172 (41%), Gaps = 17/172 (9%)
Query: 62 GALLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEE-------DGEVKDYG---- 110
G L L + + A+DK LE + +K ++ +LSL +E ++K+
Sbjct: 1106 GDLKLTQESVADAAQDKQQLEEKLKKKDSELSQLSLRVEDEQLLGAQMQKKIKELQARAE 1165
Query: 111 --EEDLQLRHIKRPEGRKPSEVAHKSIEAVVARLEKQNGLSLG-HSTCPEEVFVEASPGT 167
EE+L+ R K A + +E + RLE+ G S G C + EA G
Sbjct: 1166 ELEEELEAERAARARVEKQRAEAARELEELSERLEEAGGASAGQREGCRKR---EAELGR 1222
Query: 168 EDMDSLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLK 219
+ E A+ A L R + E+ L+R R++L ++ +L+
Sbjct: 1223 LRRELEEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKSELR 1274
Score = 33.5 bits (75), Expect = 0.37
Identities = 43/177 (24%), Positives = 77/177 (43%), Gaps = 36/177 (20%)
Query: 112 EDLQLRH------IKRPEGRKPSEVAHK--SIEAVVARLEKQNGLSLGHSTCPEEVFVEA 163
E+ LRH ++R + +E+ + S++ V +LEK+ E+ +E
Sbjct: 1228 EEAALRHEATVAALRRKQAEGAAELGEQVDSLQRVRQKLEKEKS----------ELRMEV 1277
Query: 164 SPGTEDMDSLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGA 223
++++L A +A E+L R Y+ Q E + +EL+R Q A + G
Sbjct: 1278 DDLAANVETLTRA---KASAEKLCRTYEDQLSEAKIKVEELQR------QLADASTQRGR 1328
Query: 224 LVSEMKELRDLNRRLQDVLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSEEANTSS 280
L +E EL L ++ L+ +L G A+ + ++ ELR EE+ S
Sbjct: 1329 LQTESGELSRLLEE-KECLISQLSRGKALAAQSLE--------ELRRQLEEESKAKS 1376
>gi|31542634 filamin A interacting protein 1 [Homo sapiens]
Length = 1213
Score = 40.4 bits (93), Expect = 0.003
Identities = 49/209 (23%), Positives = 92/209 (44%), Gaps = 47/209 (22%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGE----EDLQLRHIK--- 120
K+ + L +++ ++ + Q++ K+ L+ N E G+V D E E +L +K
Sbjct: 502 KSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEM 561
Query: 121 ------------------RPEGRKPSEVAHKSIEAVVARL----EKQNGLSLGHS----- 153
+ E K SE++ S++ + RL E + ++ G S
Sbjct: 562 EEKVYNLTRERDELIGKLKSEEEKSSELSC-SVDLLKKRLDGIEEVEREITRGRSRKGSE 620
Query: 154 -TCPE-----EVFVEASPGTEDMDSLE----DAVVPRALYEELLRNYQQQQEEMRHLQQE 203
TCPE E+ +E + + LE D + Y++L + ++ +Q++ L Q+
Sbjct: 621 LTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQ 680
Query: 204 LERTRRQLVQQAKKLKEYGALVSEMKELR 232
LE + Q+ + K E G +VS+ ELR
Sbjct: 681 LEEIKHQIAK--NKAIEKGEVVSQEAELR 707
>gi|239754018 PREDICTED: hypothetical protein LOC100129791 [Homo
sapiens]
Length = 338
Score = 40.0 bits (92), Expect = 0.004
Identities = 29/102 (28%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 144 KQNGLSLGHSTCPEEVFVEASPGTE------DMDSLEDAVVPRALYEELLRNYQQQQEEM 197
++ G S S P +SP TE D D L +A R+ Y EL + Q + +E+
Sbjct: 7 RKTGNSKKQSASPPPKECSSSPATEQSWMENDFDELREAGFRRSNYSELREDIQTKGKEV 66
Query: 198 RHLQQELERTRRQLVQQAKKLKEYGALVSEMKELRDLNRRLQ 239
+ ++ LE ++ K LKE L ++ +EL + R L+
Sbjct: 67 ENFEKNLEECITRITNTEKCLKELMELKTKARELCEECRSLR 108
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 39.7 bits (91), Expect = 0.005
Identities = 32/151 (21%), Positives = 68/151 (45%), Gaps = 3/151 (1%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSL--NHVEEDGEVKDYGEEDLQLRHIKRPEGR 125
KA+ A +S +E + ++++ +LS +E + ++D R ++ E
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAE 2271
Query: 126 KPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEE 185
K +VA ++ VA E L ++ + E M ++++A +A E
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2331
Query: 186 LLRNYQQQQEEMRHLQQELERTRRQLVQQAK 216
L + + QE+ R LQ++ E+ +QL ++ +
Sbjct: 2332 LQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Score = 37.7 bits (86), Expect = 0.020
Identities = 52/210 (24%), Positives = 96/210 (45%), Gaps = 21/210 (10%)
Query: 49 AGPESPPRAPRDWGALLLHKAQILALAEDKSDLENSVMQK---KIKIPKLSLNHVEEDGE 105
A E+ RA + AL +A + + K E ++ QK + ++ L L +EE
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDH 2200
Query: 106 VKDYGEEDLQLRHIKRPEG-RKPSEVAHK---------SIEAVVARLEKQNGLSLGHSTC 155
K+ +E+LQ + E R+ S+V + + + AR+E +N +
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2260
Query: 156 PEEVFVEASPGTEDMDSL-EDAVVPRALYEELLRNYQQQQEEM---RHLQQELERTRRQL 211
+ F++ E M + E+A +E R Q +E++ R L +++ + + Q
Sbjct: 2261 NTQRFLQEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 212 VQQAKKLKEYGALVSEMKEL-RDLNRRLQD 240
VQ+A +LK L+ + KEL ++ RRLQ+
Sbjct: 2319 VQEATRLKAEAELLQQQKELAQEQARRLQE 2348
Score = 30.0 bits (66), Expect = 4.1
Identities = 42/192 (21%), Positives = 78/192 (40%), Gaps = 27/192 (14%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKP 127
+ Q + E E + +K + L + + D + + E +L K ++
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2466
Query: 128 SEVAHKSIEAVVARLEK---------QNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVV 178
+ KS E + E+ Q+ LS S E F+E ++ LE
Sbjct: 2467 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE-----QEKAKLEQ--- 2518
Query: 179 PRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSE-----MKELRD 233
L+++ + QQ +EE + QQ++E+ R++LV ++ + E +EL+
Sbjct: 2519 ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 234 L--NRRLQDVLL 243
L RR Q+ LL
Sbjct: 2576 LEQQRRQQEELL 2587
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 39.7 bits (91), Expect = 0.005
Identities = 32/151 (21%), Positives = 68/151 (45%), Gaps = 3/151 (1%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSL--NHVEEDGEVKDYGEEDLQLRHIKRPEGR 125
KA+ A +S +E + ++++ +LS +E + ++D R ++ E
Sbjct: 2217 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAE 2275
Query: 126 KPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEE 185
K +VA ++ VA E L ++ + E M ++++A +A E
Sbjct: 2276 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2335
Query: 186 LLRNYQQQQEEMRHLQQELERTRRQLVQQAK 216
L + + QE+ R LQ++ E+ +QL ++ +
Sbjct: 2336 LQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Score = 37.7 bits (86), Expect = 0.020
Identities = 52/210 (24%), Positives = 96/210 (45%), Gaps = 21/210 (10%)
Query: 49 AGPESPPRAPRDWGALLLHKAQILALAEDKSDLENSVMQK---KIKIPKLSLNHVEEDGE 105
A E+ RA + AL +A + + K E ++ QK + ++ L L +EE
Sbjct: 2146 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDH 2204
Query: 106 VKDYGEEDLQLRHIKRPEG-RKPSEVAHK---------SIEAVVARLEKQNGLSLGHSTC 155
K+ +E+LQ + E R+ S+V + + + AR+E +N +
Sbjct: 2205 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2264
Query: 156 PEEVFVEASPGTEDMDSL-EDAVVPRALYEELLRNYQQQQEEM---RHLQQELERTRRQL 211
+ F++ E M + E+A +E R Q +E++ R L +++ + + Q
Sbjct: 2265 NTQRFLQEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2322
Query: 212 VQQAKKLKEYGALVSEMKEL-RDLNRRLQD 240
VQ+A +LK L+ + KEL ++ RRLQ+
Sbjct: 2323 VQEATRLKAEAELLQQQKELAQEQARRLQE 2352
Score = 30.0 bits (66), Expect = 4.1
Identities = 42/192 (21%), Positives = 78/192 (40%), Gaps = 27/192 (14%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKP 127
+ Q + E E + +K + L + + D + + E +L K ++
Sbjct: 2411 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2470
Query: 128 SEVAHKSIEAVVARLEK---------QNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVV 178
+ KS E + E+ Q+ LS S E F+E ++ LE
Sbjct: 2471 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE-----QEKAKLEQ--- 2522
Query: 179 PRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSE-----MKELRD 233
L+++ + QQ +EE + QQ++E+ R++LV ++ + E +EL+
Sbjct: 2523 ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2579
Query: 234 L--NRRLQDVLL 243
L RR Q+ LL
Sbjct: 2580 LEQQRRQQEELL 2591
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 39.7 bits (91), Expect = 0.005
Identities = 32/151 (21%), Positives = 68/151 (45%), Gaps = 3/151 (1%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSL--NHVEEDGEVKDYGEEDLQLRHIKRPEGR 125
KA+ A +S +E + ++++ +LS +E + ++D R ++ E
Sbjct: 2213 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAE 2271
Query: 126 KPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEE 185
K +VA ++ VA E L ++ + E M ++++A +A E
Sbjct: 2272 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2331
Query: 186 LLRNYQQQQEEMRHLQQELERTRRQLVQQAK 216
L + + QE+ R LQ++ E+ +QL ++ +
Sbjct: 2332 LQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Score = 37.7 bits (86), Expect = 0.020
Identities = 52/210 (24%), Positives = 96/210 (45%), Gaps = 21/210 (10%)
Query: 49 AGPESPPRAPRDWGALLLHKAQILALAEDKSDLENSVMQK---KIKIPKLSLNHVEEDGE 105
A E+ RA + AL +A + + K E ++ QK + ++ L L +EE
Sbjct: 2142 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDH 2200
Query: 106 VKDYGEEDLQLRHIKRPEG-RKPSEVAHK---------SIEAVVARLEKQNGLSLGHSTC 155
K+ +E+LQ + E R+ S+V + + + AR+E +N +
Sbjct: 2201 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2260
Query: 156 PEEVFVEASPGTEDMDSL-EDAVVPRALYEELLRNYQQQQEEM---RHLQQELERTRRQL 211
+ F++ E M + E+A +E R Q +E++ R L +++ + + Q
Sbjct: 2261 NTQRFLQEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2318
Query: 212 VQQAKKLKEYGALVSEMKEL-RDLNRRLQD 240
VQ+A +LK L+ + KEL ++ RRLQ+
Sbjct: 2319 VQEATRLKAEAELLQQQKELAQEQARRLQE 2348
Score = 30.0 bits (66), Expect = 4.1
Identities = 42/192 (21%), Positives = 78/192 (40%), Gaps = 27/192 (14%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKP 127
+ Q + E E + +K + L + + D + + E +L K ++
Sbjct: 2407 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2466
Query: 128 SEVAHKSIEAVVARLEK---------QNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVV 178
+ KS E + E+ Q+ LS S E F+E ++ LE
Sbjct: 2467 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE-----QEKAKLEQ--- 2518
Query: 179 PRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSE-----MKELRD 233
L+++ + QQ +EE + QQ++E+ R++LV ++ + E +EL+
Sbjct: 2519 ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2575
Query: 234 L--NRRLQDVLL 243
L RR Q+ LL
Sbjct: 2576 LEQQRRQQEELL 2587
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 39.7 bits (91), Expect = 0.005
Identities = 32/151 (21%), Positives = 68/151 (45%), Gaps = 3/151 (1%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSL--NHVEEDGEVKDYGEEDLQLRHIKRPEGR 125
KA+ A +S +E + ++++ +LS +E + ++D R ++ E
Sbjct: 2181 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAE 2239
Query: 126 KPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEE 185
K +VA ++ VA E L ++ + E M ++++A +A E
Sbjct: 2240 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2299
Query: 186 LLRNYQQQQEEMRHLQQELERTRRQLVQQAK 216
L + + QE+ R LQ++ E+ +QL ++ +
Sbjct: 2300 LQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Score = 37.7 bits (86), Expect = 0.020
Identities = 52/210 (24%), Positives = 96/210 (45%), Gaps = 21/210 (10%)
Query: 49 AGPESPPRAPRDWGALLLHKAQILALAEDKSDLENSVMQK---KIKIPKLSLNHVEEDGE 105
A E+ RA + AL +A + + K E ++ QK + ++ L L +EE
Sbjct: 2110 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDH 2168
Query: 106 VKDYGEEDLQLRHIKRPEG-RKPSEVAHK---------SIEAVVARLEKQNGLSLGHSTC 155
K+ +E+LQ + E R+ S+V + + + AR+E +N +
Sbjct: 2169 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2228
Query: 156 PEEVFVEASPGTEDMDSL-EDAVVPRALYEELLRNYQQQQEEM---RHLQQELERTRRQL 211
+ F++ E M + E+A +E R Q +E++ R L +++ + + Q
Sbjct: 2229 NTQRFLQEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2286
Query: 212 VQQAKKLKEYGALVSEMKEL-RDLNRRLQD 240
VQ+A +LK L+ + KEL ++ RRLQ+
Sbjct: 2287 VQEATRLKAEAELLQQQKELAQEQARRLQE 2316
Score = 30.0 bits (66), Expect = 4.1
Identities = 42/192 (21%), Positives = 78/192 (40%), Gaps = 27/192 (14%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKP 127
+ Q + E E + +K + L + + D + + E +L K ++
Sbjct: 2375 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2434
Query: 128 SEVAHKSIEAVVARLEK---------QNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVV 178
+ KS E + E+ Q+ LS S E F+E ++ LE
Sbjct: 2435 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE-----QEKAKLEQ--- 2486
Query: 179 PRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSE-----MKELRD 233
L+++ + QQ +EE + QQ++E+ R++LV ++ + E +EL+
Sbjct: 2487 ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2543
Query: 234 L--NRRLQDVLL 243
L RR Q+ LL
Sbjct: 2544 LEQQRRQQEELL 2555
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 39.7 bits (91), Expect = 0.005
Identities = 32/151 (21%), Positives = 68/151 (45%), Gaps = 3/151 (1%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSL--NHVEEDGEVKDYGEEDLQLRHIKRPEGR 125
KA+ A +S +E + ++++ +LS +E + ++D R ++ E
Sbjct: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAE 2408
Query: 126 KPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEE 185
K +VA ++ VA E L ++ + E M ++++A +A E
Sbjct: 2409 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2468
Query: 186 LLRNYQQQQEEMRHLQQELERTRRQLVQQAK 216
L + + QE+ R LQ++ E+ +QL ++ +
Sbjct: 2469 LQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Score = 37.7 bits (86), Expect = 0.020
Identities = 52/210 (24%), Positives = 96/210 (45%), Gaps = 21/210 (10%)
Query: 49 AGPESPPRAPRDWGALLLHKAQILALAEDKSDLENSVMQK---KIKIPKLSLNHVEEDGE 105
A E+ RA + AL +A + + K E ++ QK + ++ L L +EE
Sbjct: 2279 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDH 2337
Query: 106 VKDYGEEDLQLRHIKRPEG-RKPSEVAHK---------SIEAVVARLEKQNGLSLGHSTC 155
K+ +E+LQ + E R+ S+V + + + AR+E +N +
Sbjct: 2338 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2397
Query: 156 PEEVFVEASPGTEDMDSL-EDAVVPRALYEELLRNYQQQQEEM---RHLQQELERTRRQL 211
+ F++ E M + E+A +E R Q +E++ R L +++ + + Q
Sbjct: 2398 NTQRFLQEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2455
Query: 212 VQQAKKLKEYGALVSEMKEL-RDLNRRLQD 240
VQ+A +LK L+ + KEL ++ RRLQ+
Sbjct: 2456 VQEATRLKAEAELLQQQKELAQEQARRLQE 2485
Score = 30.0 bits (66), Expect = 4.1
Identities = 42/192 (21%), Positives = 78/192 (40%), Gaps = 27/192 (14%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKP 127
+ Q + E E + +K + L + + D + + E +L K ++
Sbjct: 2544 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2603
Query: 128 SEVAHKSIEAVVARLEK---------QNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVV 178
+ KS E + E+ Q+ LS S E F+E ++ LE
Sbjct: 2604 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE-----QEKAKLEQ--- 2655
Query: 179 PRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSE-----MKELRD 233
L+++ + QQ +EE + QQ++E+ R++LV ++ + E +EL+
Sbjct: 2656 ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2712
Query: 234 L--NRRLQDVLL 243
L RR Q+ LL
Sbjct: 2713 LEQQRRQQEELL 2724
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 39.7 bits (91), Expect = 0.005
Identities = 32/151 (21%), Positives = 68/151 (45%), Gaps = 3/151 (1%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSL--NHVEEDGEVKDYGEEDLQLRHIKRPEGR 125
KA+ A +S +E + ++++ +LS +E + ++D R ++ E
Sbjct: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAE 2249
Query: 126 KPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEE 185
K +VA ++ VA E L ++ + E M ++++A +A E
Sbjct: 2250 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2309
Query: 186 LLRNYQQQQEEMRHLQQELERTRRQLVQQAK 216
L + + QE+ R LQ++ E+ +QL ++ +
Sbjct: 2310 LQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Score = 37.7 bits (86), Expect = 0.020
Identities = 52/210 (24%), Positives = 96/210 (45%), Gaps = 21/210 (10%)
Query: 49 AGPESPPRAPRDWGALLLHKAQILALAEDKSDLENSVMQK---KIKIPKLSLNHVEEDGE 105
A E+ RA + AL +A + + K E ++ QK + ++ L L +EE
Sbjct: 2120 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDH 2178
Query: 106 VKDYGEEDLQLRHIKRPEG-RKPSEVAHK---------SIEAVVARLEKQNGLSLGHSTC 155
K+ +E+LQ + E R+ S+V + + + AR+E +N +
Sbjct: 2179 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2238
Query: 156 PEEVFVEASPGTEDMDSL-EDAVVPRALYEELLRNYQQQQEEM---RHLQQELERTRRQL 211
+ F++ E M + E+A +E R Q +E++ R L +++ + + Q
Sbjct: 2239 NTQRFLQEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2296
Query: 212 VQQAKKLKEYGALVSEMKEL-RDLNRRLQD 240
VQ+A +LK L+ + KEL ++ RRLQ+
Sbjct: 2297 VQEATRLKAEAELLQQQKELAQEQARRLQE 2326
Score = 30.0 bits (66), Expect = 4.1
Identities = 42/192 (21%), Positives = 78/192 (40%), Gaps = 27/192 (14%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKP 127
+ Q + E E + +K + L + + D + + E +L K ++
Sbjct: 2385 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2444
Query: 128 SEVAHKSIEAVVARLEK---------QNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVV 178
+ KS E + E+ Q+ LS S E F+E ++ LE
Sbjct: 2445 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE-----QEKAKLEQ--- 2496
Query: 179 PRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSE-----MKELRD 233
L+++ + QQ +EE + QQ++E+ R++LV ++ + E +EL+
Sbjct: 2497 ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2553
Query: 234 L--NRRLQDVLL 243
L RR Q+ LL
Sbjct: 2554 LEQQRRQQEELL 2565
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 39.7 bits (91), Expect = 0.005
Identities = 32/151 (21%), Positives = 68/151 (45%), Gaps = 3/151 (1%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSL--NHVEEDGEVKDYGEEDLQLRHIKRPEGR 125
KA+ A +S +E + ++++ +LS +E + ++D R ++ E
Sbjct: 2199 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAE 2257
Query: 126 KPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEE 185
K +VA ++ VA E L ++ + E M ++++A +A E
Sbjct: 2258 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2317
Query: 186 LLRNYQQQQEEMRHLQQELERTRRQLVQQAK 216
L + + QE+ R LQ++ E+ +QL ++ +
Sbjct: 2318 LQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2348
Score = 37.7 bits (86), Expect = 0.020
Identities = 52/210 (24%), Positives = 96/210 (45%), Gaps = 21/210 (10%)
Query: 49 AGPESPPRAPRDWGALLLHKAQILALAEDKSDLENSVMQK---KIKIPKLSLNHVEEDGE 105
A E+ RA + AL +A + + K E ++ QK + ++ L L +EE
Sbjct: 2128 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDH 2186
Query: 106 VKDYGEEDLQLRHIKRPEG-RKPSEVAHK---------SIEAVVARLEKQNGLSLGHSTC 155
K+ +E+LQ + E R+ S+V + + + AR+E +N +
Sbjct: 2187 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2246
Query: 156 PEEVFVEASPGTEDMDSL-EDAVVPRALYEELLRNYQQQQEEM---RHLQQELERTRRQL 211
+ F++ E M + E+A +E R Q +E++ R L +++ + + Q
Sbjct: 2247 NTQRFLQEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2304
Query: 212 VQQAKKLKEYGALVSEMKEL-RDLNRRLQD 240
VQ+A +LK L+ + KEL ++ RRLQ+
Sbjct: 2305 VQEATRLKAEAELLQQQKELAQEQARRLQE 2334
Score = 30.0 bits (66), Expect = 4.1
Identities = 42/192 (21%), Positives = 78/192 (40%), Gaps = 27/192 (14%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKP 127
+ Q + E E + +K + L + + D + + E +L K ++
Sbjct: 2393 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2452
Query: 128 SEVAHKSIEAVVARLEK---------QNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVV 178
+ KS E + E+ Q+ LS S E F+E ++ LE
Sbjct: 2453 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE-----QEKAKLEQ--- 2504
Query: 179 PRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSE-----MKELRD 233
L+++ + QQ +EE + QQ++E+ R++LV ++ + E +EL+
Sbjct: 2505 ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2561
Query: 234 L--NRRLQDVLL 243
L RR Q+ LL
Sbjct: 2562 LEQQRRQQEELL 2573
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 39.7 bits (91), Expect = 0.005
Identities = 32/151 (21%), Positives = 68/151 (45%), Gaps = 3/151 (1%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSL--NHVEEDGEVKDYGEEDLQLRHIKRPEGR 125
KA+ A +S +E + ++++ +LS +E + ++D R ++ E
Sbjct: 2240 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE-EAE 2298
Query: 126 KPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEE 185
K +VA ++ VA E L ++ + E M ++++A +A E
Sbjct: 2299 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2358
Query: 186 LLRNYQQQQEEMRHLQQELERTRRQLVQQAK 216
L + + QE+ R LQ++ E+ +QL ++ +
Sbjct: 2359 LQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
Score = 37.7 bits (86), Expect = 0.020
Identities = 52/210 (24%), Positives = 96/210 (45%), Gaps = 21/210 (10%)
Query: 49 AGPESPPRAPRDWGALLLHKAQILALAEDKSDLENSVMQK---KIKIPKLSLNHVEEDGE 105
A E+ RA + AL +A + + K E ++ QK + ++ L L +EE
Sbjct: 2169 AEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQ-LEETDH 2227
Query: 106 VKDYGEEDLQLRHIKRPEG-RKPSEVAHK---------SIEAVVARLEKQNGLSLGHSTC 155
K+ +E+LQ + E R+ S+V + + + AR+E +N +
Sbjct: 2228 QKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD 2287
Query: 156 PEEVFVEASPGTEDMDSL-EDAVVPRALYEELLRNYQQQQEEM---RHLQQELERTRRQL 211
+ F++ E M + E+A +E R Q +E++ R L +++ + + Q
Sbjct: 2288 NTQRFLQEE--AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQA 2345
Query: 212 VQQAKKLKEYGALVSEMKEL-RDLNRRLQD 240
VQ+A +LK L+ + KEL ++ RRLQ+
Sbjct: 2346 VQEATRLKAEAELLQQQKELAQEQARRLQE 2375
Score = 30.0 bits (66), Expect = 4.1
Identities = 42/192 (21%), Positives = 78/192 (40%), Gaps = 27/192 (14%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKP 127
+ Q + E E + +K + L + + D + + E +L K ++
Sbjct: 2434 RKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA 2493
Query: 128 SEVAHKSIEAVVARLEK---------QNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVV 178
+ KS E + E+ Q+ LS S E F+E ++ LE
Sbjct: 2494 KLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE-----QEKAKLEQ--- 2545
Query: 179 PRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSE-----MKELRD 233
L+++ + QQ +EE + QQ++E+ R++LV ++ + E +EL+
Sbjct: 2546 ---LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQ 2602
Query: 234 L--NRRLQDVLL 243
L RR Q+ LL
Sbjct: 2603 LEQQRRQQEELL 2614
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 39.3 bits (90), Expect = 0.007
Identities = 41/200 (20%), Positives = 91/200 (45%), Gaps = 11/200 (5%)
Query: 77 DKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKPSEVAHKSIE 136
++ + N ++Q + K + + +EE + ++ + LQL + +E K +E
Sbjct: 932 EEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVT-------AEAKIKKME 984
Query: 137 AVVARLEKQNGLSLGHSTCPEEVFVEASPG-TEDMDSLEDAVVPRALYEELLRNYQQQQE 195
+ LE QN + E+ E S E+ + ++ R E ++ + +++ +
Sbjct: 985 EEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK 1044
Query: 196 EMRHLQQELERTRRQLVQQAKKLKEYGA-LVSEMKELRDLNRRLQDVLLLRLGSGPAIDL 254
+ +QELE+ +R+L + L++ A L +++ EL+ + ++ L L G L
Sbjct: 1045 KEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETL 1104
Query: 255 EKVKSECLEPEPELRSTFSE 274
K+ L+ EL++ +E
Sbjct: 1105 H--KNNALKVVRELQAQIAE 1122
Score = 29.3 bits (64), Expect = 7.0
Identities = 39/201 (19%), Positives = 85/201 (42%), Gaps = 31/201 (15%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEE-----DGEVKDYGEE---------D 113
KA+ LA +K ++ S +++++K + + +E+ DGE D ++ +
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080
Query: 114 LQLRHIKRPE------GRKPSEVAHKS--------IEAVVARLEKQNGLSLGHSTCPEEV 159
L+L+ K+ E R E HK+ ++A +A L++ E+
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQ 1140
Query: 160 FVEASPGTEDMDS-LEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKL 218
+ S E + + LED + A +EL +Q+ E++ +E + +Q +
Sbjct: 1141 KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMR-- 1198
Query: 219 KEYGALVSEMKELRDLNRRLQ 239
+ + + E+ E + +R +
Sbjct: 1199 QRHATALEELSEQLEQAKRFK 1219
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 38.5 bits (88), Expect = 0.012
Identities = 40/167 (23%), Positives = 81/167 (48%), Gaps = 12/167 (7%)
Query: 64 LLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEE--DLQLRHIKR 121
L + + QI L +D+ N + + +++ K + G+V+D ++ L+ ++
Sbjct: 1503 LTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALEL 1562
Query: 122 PEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCP-EEVFVEASPGTEDMDSLED--AVV 178
E E K I+ + + E Q ++L H T EE E + + LE V+
Sbjct: 1563 EENHHKMECQQKLIKELEGQRETQR-VALTHLTLDLEERSQELQAQSSQIHDLESHSTVL 1621
Query: 179 PRALYE--ELLRNYQQQQEEMR----HLQQELERTRRQLVQQAKKLK 219
R L E + +++ ++Q EE++ HL Q+LER ++L+ Q ++++
Sbjct: 1622 ARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQ 1668
Score = 33.9 bits (76), Expect = 0.28
Identities = 43/187 (22%), Positives = 81/187 (43%), Gaps = 16/187 (8%)
Query: 85 VMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKPSEVAHKSIEAVVARLEK 144
+++ K K + H+ E E+KD E+ LQ H R G ++ + E VV + +
Sbjct: 1730 ILRDKEKEVECQQEHIHELQELKDQLEQQLQGLH--RKVGETSLLLSQREQEIVVLQQQL 1787
Query: 145 QNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEELLRNYQQQ-QEEMRHLQQE 203
Q G ++ +D + A+ R E L+ QQQ Q + ++++
Sbjct: 1788 QEAREQGE--------LKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEK 1839
Query: 204 LERTRRQLVQQAKKLKEYGALVSEMKELRDLNRRLQDVLLLRLGSGPAID--LEKVKSEC 261
+ + L Q LKE E+++ ++ RRL++ L + A++ L +++E
Sbjct: 1840 ADALQGALEQAHMTLKERH---GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES 1896
Query: 262 LEPEPEL 268
E E L
Sbjct: 1897 REQEKAL 1903
Score = 30.8 bits (68), Expect = 2.4
Identities = 39/164 (23%), Positives = 72/164 (43%), Gaps = 19/164 (11%)
Query: 68 KAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEE-DLQLRHIKRPEGRK 126
KAQ LAL+ ++ S +Q+ + S+ +E D E + +E +L R +++
Sbjct: 2172 KAQDLALSLAQTKASVSSLQEVAMFLQASV--LERDSEQQRLQDELELTRRALEKERLHS 2229
Query: 127 PSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDS------LEDAVVPR 180
P + + + + G+ LG E VEA P + M+ LE
Sbjct: 2230 PGATSTAELGS-----RGEQGVQLG-----EVSGVEAEPSPDGMEKQSWRQRLEHLQQAV 2279
Query: 181 ALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGAL 224
A E Q+ ++R +++ER RR+L ++A + + G+L
Sbjct: 2280 ARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSL 2323
Score = 30.0 bits (66), Expect = 4.1
Identities = 20/62 (32%), Positives = 36/62 (58%), Gaps = 5/62 (8%)
Query: 186 LLRNYQQQQEEMRHLQQELERTRRQL-VQQAKKLKEYGALVSEM----KELRDLNRRLQD 240
LL Q Q+E+ Q+LER R+ + VQ+ K+ + G L +++ +EL++ R+ +D
Sbjct: 930 LLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRD 989
Query: 241 VL 242
L
Sbjct: 990 DL 991
Score = 29.6 bits (65), Expect = 5.4
Identities = 28/117 (23%), Positives = 53/117 (45%), Gaps = 13/117 (11%)
Query: 133 KSIEAVVARLEKQNGLSLGHSTCPEEVF--VEASPGTEDMDSLEDAVVPRALYEELLRNY 190
+S+EA A L+ HS EE E +D+ ED ++L +
Sbjct: 1992 RSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDV-------QQLQQAL 2044
Query: 191 QQQQEEMRHLQQELERTRRQLVQQAK----KLKEYGALVSEMKELRDLNRRLQDVLL 243
Q+ EE+RH Q+ + + L Q+ + + K+ E +E+R L++ ++++ L
Sbjct: 2045 AQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQL 2101
>gi|239787821 syncoilin, intermediate filament 1 isoform 2 [Homo
sapiens]
Length = 476
Score = 38.1 bits (87), Expect = 0.015
Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 19/131 (14%)
Query: 99 HVEEDGE------VKDYGEEDLQLRHIKRP-EGRKPSEVAHKSIEA-VVARLEKQNGLSL 150
HVEE G V++ E D +++ ++ P E KP+ H E V R EK N
Sbjct: 96 HVEEPGNPEETVCVEETTEPD-RIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSN---- 150
Query: 151 GHSTCPEEVF-VEASPGTEDMDSLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRR 209
PEE E SP E+ S+ED + +++ ++ Q +EE L EL R
Sbjct: 151 -----PEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLRE 205
Query: 210 QLVQQAKKLKE 220
+Q+ +++ +
Sbjct: 206 PALQEVQQVHQ 216
Score = 30.0 bits (66), Expect = 4.1
Identities = 23/94 (24%), Positives = 51/94 (54%), Gaps = 5/94 (5%)
Query: 187 LRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMK--ELRDLNRRLQDVLLL 244
L+ Q + +EM+ + L+ RQL Q + L++ ALV + + E++ +L+++
Sbjct: 361 LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER 420
Query: 245 RLGSGPAIDLEKVKSECLEPEPELRSTFSEEANT 278
+ + L++ K++ +E +LR + +EE +T
Sbjct: 421 QRQLRNGVQLQQQKNKEME---QLRLSLAEELST 451
>gi|166706887 syncoilin, intermediate filament 1 isoform 1 [Homo
sapiens]
Length = 482
Score = 38.1 bits (87), Expect = 0.015
Identities = 37/131 (28%), Positives = 60/131 (45%), Gaps = 19/131 (14%)
Query: 99 HVEEDGE------VKDYGEEDLQLRHIKRP-EGRKPSEVAHKSIEA-VVARLEKQNGLSL 150
HVEE G V++ E D +++ ++ P E KP+ H E V R EK N
Sbjct: 96 HVEEPGNPEETVCVEETTEPD-RIQFVEGPVEPGKPTSPEHVVYEGETVTRAEKSN---- 150
Query: 151 GHSTCPEEVF-VEASPGTEDMDSLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRR 209
PEE E SP E+ S+ED + +++ ++ Q +EE L EL R
Sbjct: 151 -----PEESLRAEQSPSVEENLSIEDLELLEGRFQQCVQAVAQLEEERDQLIHELVLLRE 205
Query: 210 QLVQQAKKLKE 220
+Q+ +++ +
Sbjct: 206 PALQEVQQVHQ 216
Score = 30.0 bits (66), Expect = 4.1
Identities = 23/94 (24%), Positives = 51/94 (54%), Gaps = 5/94 (5%)
Query: 187 LRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMK--ELRDLNRRLQDVLLL 244
L+ Q + +EM+ + L+ RQL Q + L++ ALV + + E++ +L+++
Sbjct: 361 LQRTQAEIQEMKEALRPLQAEARQLRLQNRNLEDQIALVRQKRDEEVQQYREQLEEMEER 420
Query: 245 RLGSGPAIDLEKVKSECLEPEPELRSTFSEEANT 278
+ + L++ K++ +E +LR + +EE +T
Sbjct: 421 QRQLRNGVQLQQQKNKEME---QLRLSLAEELST 451
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 38.1 bits (87), Expect = 0.015
Identities = 35/103 (33%), Positives = 54/103 (52%), Gaps = 9/103 (8%)
Query: 172 SLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSE--MK 229
S +D R + + LR Q+ QEE+R L E+E RRQL+Q+ + +K+ L +E K
Sbjct: 1629 SEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQ-AHLRNEHFQK 1687
Query: 230 ELRDLNRRLQD--VLLLRLGSGPAIDLEKVKSECLEPEPELRS 270
+ D +R L + + + RL S E + E L E ELR+
Sbjct: 1688 AIEDKSRSLNESKIEIERLQS----LTENLTKEHLMLEEELRN 1726
Score = 37.0 bits (84), Expect = 0.034
Identities = 35/167 (20%), Positives = 79/167 (47%), Gaps = 8/167 (4%)
Query: 80 DLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHIKRPEGRKPSEVAHKSIEAVV 139
D ++ K +I +L +E + K +E+ +L+ ++ + +K + A ++I +
Sbjct: 1471 DAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQY-DLQKANSSATETINKLK 1529
Query: 140 ARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSLEDAVVPRALYEELLRNYQQQQEE--- 196
+ ++ L + + +E V+ T +SL++ + + EE L ++ E
Sbjct: 1530 VQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSC 1589
Query: 197 -MRHLQQELERTRRQLVQQAKKLKEYGALVSEMKELRDLNRRLQDVL 242
+ L++ELE RR L +QA K+ L ++++ + +R +D L
Sbjct: 1590 KRKKLEEELEGMRRSLKEQAIKITN---LTQQLEQASIVKKRSEDDL 1633
Score = 29.3 bits (64), Expect = 7.0
Identities = 44/193 (22%), Positives = 76/193 (39%), Gaps = 26/193 (13%)
Query: 71 ILALAEDKSDLENSVMQKKIKIPKL--SLNHVE-EDGEVKDYGEEDLQLRHIKRPEGRKP 127
IL E + E + +Q+K ++ H+E E +V ED E K
Sbjct: 1260 ILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLEEAAKT 1319
Query: 128 SEVAHKSIEAVVA--------RLEKQNGLSLGHSTCPEEVF------------VEASPGT 167
+ +K IE + A R E +N LS + EE+ + +
Sbjct: 1320 IQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQ 1379
Query: 168 EDMDSLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTR---RQLVQQAKKLKEYGAL 224
M ED RA + L R + EE++ L+ L +T R++ + ++ K G+
Sbjct: 1380 LTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSE 1439
Query: 225 VSEMKELRDLNRR 237
VS+ K+ ++ R
Sbjct: 1440 VSQRKQQLEVELR 1452
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 38.1 bits (87), Expect = 0.015
Identities = 49/228 (21%), Positives = 98/228 (42%), Gaps = 29/228 (12%)
Query: 61 WGALLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRH-- 118
W L ++LA AE+ S +E S ++K L LN + E+ + L L +
Sbjct: 1799 WEKKLAQTKRVLAAAEENSKMEQSNLEK------LELNVRKLQQELDQLNRDKLSLHNDI 1852
Query: 119 IKRPEGRKPSEVAHKSIEAVVARLEKQNGLS---LGHSTCPEEVFVEASPGTEDMDSLED 175
+ + A S++ +A ++ L+ L H+T ++V + +E +D
Sbjct: 1853 SAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLL-----SEQTRLQKD 1907
Query: 176 AVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQ--------QAKKLKEYGALVSE 227
+E+ + + +Q++++ LQ E+E + +LVQ Q ++ E L +
Sbjct: 1908 ISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQKERESEESKLETS 1967
Query: 228 MKELRDLNRRLQDVLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSEE 275
L++ +L+ L + L++V S+ L E +R+ EE
Sbjct: 1968 KVTLKEQQHQLEKEL-----TDQKSKLDQVLSKVLAAEERVRTLQEEE 2010
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 37.4 bits (85), Expect = 0.026
Identities = 70/377 (18%), Positives = 146/377 (38%), Gaps = 58/377 (15%)
Query: 62 GALLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDG-------EVKDYG---- 110
G L L + I+ + +K L+ + +K+ +I L +E ++K+
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE 1122
Query: 111 --EEDLQLRHIKRPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTE 168
EE+++ R + K + +E + RLE+ G + ++ E
Sbjct: 1123 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182
Query: 169 DMDSLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEM 228
D++ E + A L + + E+ L+R +++L ++ ++K
Sbjct: 1183 DLE--EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK--------- 1231
Query: 229 KELRDLNRRLQDVLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSEEANTSSYYPAPAPV 288
E+ DL ++ V S +LEK+ + EL+S E+ +
Sbjct: 1232 MEIDDLASNVETV------SKAKGNLEKMCRTLEDQLSELKSKEEEQQR----------L 1275
Query: 289 MDKYILDNGKVHLGSGIW---VDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTG 345
++ G++ SG + +DE++ Q+++G +T+ + + LK +
Sbjct: 1276 INDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQI-------EELKRQLEEE 1328
Query: 346 VATKKKKDAVPKPPLSPHKLSIVRECLYDRIAQETVDETEIAQRLSKVNKYICE--KIMD 403
+ K K S H ++RE + +E + E+ + LSK N + + +
Sbjct: 1329 I--KAKNALAHALQSSRHDCDLLRE----QYEEEQESKAELQRALSKANTEVAQWRTKYE 1382
Query: 404 INKSCKNEERREAKYNL 420
+ + EE EAK L
Sbjct: 1383 TDAIQRTEELEEAKKKL 1399
Score = 28.9 bits (63), Expect = 9.2
Identities = 26/115 (22%), Positives = 53/115 (46%), Gaps = 15/115 (13%)
Query: 157 EEVFVEASPGTEDMDSLEDAVVP-RALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQA 215
EE E ++ SL + + YEE L + + E ++LQQE+ Q+ +
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 216 KKLKEYGALVSEMKELR-DLNRRLQDV---------LLLRLGSGPAIDLEKVKSE 260
K++ E + ++++ + +L L++ +LR+ ++L +VKSE
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI----QLELNQVKSE 1577
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 37.4 bits (85), Expect = 0.026
Identities = 70/377 (18%), Positives = 146/377 (38%), Gaps = 58/377 (15%)
Query: 62 GALLLHKAQILALAEDKSDLENSVMQKKIKIPKLSLNHVEEDG-------EVKDYG---- 110
G L L + I+ + +K L+ + +K+ +I L +E ++K+
Sbjct: 1063 GDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIE 1122
Query: 111 --EEDLQLRHIKRPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTE 168
EE+++ R + K + +E + RLE+ G + ++ E
Sbjct: 1123 ELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRR 1182
Query: 169 DMDSLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEM 228
D++ E + A L + + E+ L+R +++L ++ ++K
Sbjct: 1183 DLE--EATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMK--------- 1231
Query: 229 KELRDLNRRLQDVLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSEEANTSSYYPAPAPV 288
E+ DL ++ V S +LEK+ + EL+S E+ +
Sbjct: 1232 MEIDDLASNVETV------SKAKGNLEKMCRTLEDQLSELKSKEEEQQR----------L 1275
Query: 289 MDKYILDNGKVHLGSGIW---VDEEKWHQLQVTQGDSKYTKNLAVMIWGTDVLKNRSVTG 345
++ G++ SG + +DE++ Q+++G +T+ + + LK +
Sbjct: 1276 INDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQI-------EELKRQLEEE 1328
Query: 346 VATKKKKDAVPKPPLSPHKLSIVRECLYDRIAQETVDETEIAQRLSKVNKYICE--KIMD 403
+ K K S H ++RE + +E + E+ + LSK N + + +
Sbjct: 1329 I--KAKNALAHALQSSRHDCDLLRE----QYEEEQESKAELQRALSKANTEVAQWRTKYE 1382
Query: 404 INKSCKNEERREAKYNL 420
+ + EE EAK L
Sbjct: 1383 TDAIQRTEELEEAKKKL 1399
Score = 28.9 bits (63), Expect = 9.2
Identities = 26/115 (22%), Positives = 53/115 (46%), Gaps = 15/115 (13%)
Query: 157 EEVFVEASPGTEDMDSLEDAVVP-RALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQA 215
EE E ++ SL + + YEE L + + E ++LQQE+ Q+ +
Sbjct: 1467 EETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGG 1526
Query: 216 KKLKEYGALVSEMKELR-DLNRRLQDV---------LLLRLGSGPAIDLEKVKSE 260
K++ E + ++++ + +L L++ +LR+ ++L +VKSE
Sbjct: 1527 KRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKILRI----QLELNQVKSE 1577
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 37.0 bits (84), Expect = 0.034
Identities = 54/227 (23%), Positives = 90/227 (39%), Gaps = 23/227 (10%)
Query: 60 DWGALLLH--KAQILALAEDKSDLENSVMQKKIKIPKL--SLNHVEEDGEVKDYGEEDLQ 115
D G L H + Q++ L ++ K++ + L + +EE E K EE L+
Sbjct: 432 DQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLR 491
Query: 116 LRH--IKRPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGTEDMDSL 173
LR + +G EVA + E R + Q E++ T+D L
Sbjct: 492 LRERELTALKGALKEEVASRDQEVEHVRQQYQRDT--------EQLRRSMQDATQDHAVL 543
Query: 174 E-DAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMKE-- 230
E + AL L R ++ EE H Q ++ + L ++L + EM+E
Sbjct: 544 EAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEEEL 603
Query: 231 ---LRDLNRRLQDVLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSE 274
+ L R L+ R +G +E +K E L + EL+ +E
Sbjct: 604 GEKIEVLQRELEQA---RASAGDTRQVEVLKKELLRTQEELKELQAE 647
Score = 30.8 bits (68), Expect = 2.4
Identities = 48/241 (19%), Positives = 103/241 (42%), Gaps = 30/241 (12%)
Query: 22 RDFSPRSRLDFDNQKVYAVYRGPEELGAGPESPPRAPRDWGALLLHKAQILALAEDKS-- 79
++ +P +D +Y + R G + R +L+L K Q L + S
Sbjct: 303 QEAAPPGSVDHMKATIYGILR------EGSSESETSVRRKVSLVLEKMQPLVMVSSGSTK 356
Query: 80 -------------DLENSVMQKKIKIPKLSLNHVEEDGEVKDYGEEDLQLRHI-KRPEGR 125
+L+ + ++ K KL + V + ++++ EE +L+ + +R +G
Sbjct: 357 AVAGQGELTRKVEELQRKLDEEVKKRQKLEPSQVGLERQLEEKTEECSRLQELLERRKGE 416
Query: 126 KPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVF--VEASPGTEDMDS--LEDAVVPRA 181
++ ++K ++ + L++ L G T E+ ++ G E L+D + R
Sbjct: 417 --AQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLLKDLLETRE 474
Query: 182 LYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSE--MKELRDLNRRLQ 239
L EE+L Q+ +E++R ++EL + L ++ + V + ++ L R +Q
Sbjct: 475 LLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQ 534
Query: 240 D 240
D
Sbjct: 535 D 535
>gi|81295816 nasopharyngeal epithelium specific protein 1 [Homo
sapiens]
Length = 551
Score = 37.0 bits (84), Expect = 0.034
Identities = 27/122 (22%), Positives = 65/122 (53%), Gaps = 3/122 (2%)
Query: 174 EDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSEMKELRD 233
E+ + + + E ++ Q+Q+E R ++E R RRQ+V+Q +K +E +L++E +E ++
Sbjct: 224 EEKRLDQMMEVERQKSIQRQEELERKRREERIRGRRQIVEQMEKNQEERSLLAEQRE-QE 282
Query: 234 LNRRLQDVLLLRLGSGPAIDLEKVKSECLEPEPELRSTFSEEANTSSYYPAPAPVMDKYI 293
+ L+ + +L D+E+ + + L+ + E++ E + A + D+ +
Sbjct: 283 KEQMLE--YMEQLQEEDLKDMERRQQQKLKMQAEIKRINDENQKQKAELLAQEKLADQMV 340
Query: 294 LD 295
++
Sbjct: 341 ME 342
>gi|22027525 Rac/Cdc42 guanine nucleotide exchange factor 6 [Homo
sapiens]
Length = 776
Score = 36.6 bits (83), Expect = 0.044
Identities = 46/220 (20%), Positives = 83/220 (37%), Gaps = 37/220 (16%)
Query: 50 GPESPPRAPRDWGALLLHKAQIL--ALAEDKSDLENSVMQKKIKIPKLSLNHVEEDGEVK 107
GP PP+ + W L A L + A + + ++++ K PK +
Sbjct: 578 GPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLH------ 631
Query: 108 DYGEEDLQLRHIKRPEGRKPSEVAHKSIEAVVARLEKQNGLSLGHSTCPEEVFVEASPGT 167
KR RKPSE + ++ A E L + + C F + +
Sbjct: 632 ------------KRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSS 679
Query: 168 EDMDSLEDAVVPRALYEELLRNYQQQQEEMRHLQQELERTRRQLVQQAKKLKEYGALVSE 227
DS+ ++P EE + + +E + ++++ + AL E
Sbjct: 680 TRKDSIPQVLLP---------------EEEKLIIEETRSNGQTIMEEKSLVDTVYALKDE 724
Query: 228 MKELRDLNRRLQDVLLLRLGSGPAIDLEKVKSECLEPEPE 267
++EL+ N+R++ L L S DLEK+ L+ E
Sbjct: 725 VRELKQENKRMKQCLEEELKS--RRDLEKLVRRLLKQTDE 762
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.132 0.377
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,479,209
Number of Sequences: 37866
Number of extensions: 851077
Number of successful extensions: 5475
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 111
Number of HSP's successfully gapped in prelim test: 326
Number of HSP's that attempted gapping in prelim test: 4192
Number of HSP's gapped (non-prelim): 1479
length of query: 421
length of database: 18,247,518
effective HSP length: 105
effective length of query: 316
effective length of database: 14,271,588
effective search space: 4509821808
effective search space used: 4509821808
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.