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Search of human proteins with 187608516
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187608516 centaurin, beta 2 [Homo sapiens]
(778 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187608516 centaurin, beta 2 [Homo sapiens] 1546 0.0
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 912 0.0
gi|7661880 centaurin beta1 [Homo sapiens] 736 0.0
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 184 2e-46
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 184 2e-46
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 184 3e-46
gi|46094081 development and differentiation enhancing factor 1 [... 180 5e-45
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 177 3e-44
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 132 9e-31
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 132 1e-30
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 131 2e-30
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 131 3e-30
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 130 4e-30
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 130 5e-30
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 129 8e-30
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 129 8e-30
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 129 1e-29
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 129 1e-29
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 129 1e-29
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 129 1e-29
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 129 1e-29
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 127 3e-29
gi|208022687 GTPase regulator associated with the focal adhesion... 121 3e-27
gi|7662208 GTPase regulator associated with the focal adhesion k... 121 3e-27
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 114 5e-25
gi|21264558 stromal membrane-associated GTPase-activating protei... 110 5e-24
gi|24586663 adaptor protein, phosphotyrosine interaction, PH dom... 109 1e-23
gi|6912242 adaptor protein, phosphotyrosine interaction, PH doma... 106 9e-23
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 102 1e-21
gi|113204622 stromal membrane-associated GTPase-activating prote... 102 1e-21
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 1546 bits (4002), Expect = 0.0
Identities = 778/778 (100%), Positives = 778/778 (100%)
Query: 1 MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFM 60
MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFM
Sbjct: 1 MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFM 60
Query: 61 NGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKF 120
NGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKF
Sbjct: 61 NGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKF 120
Query: 121 KDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVL 180
KDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVL
Sbjct: 121 KDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVL 180
Query: 181 QSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQ 240
QSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQ
Sbjct: 181 QSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQ 240
Query: 241 KHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQK 300
KHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQK
Sbjct: 241 KHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQK 300
Query: 301 KFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSI 360
KFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSI
Sbjct: 301 KFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSI 360
Query: 361 ATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLA 420
ATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLA
Sbjct: 361 ATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLA 420
Query: 421 DPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYE 480
DPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYE
Sbjct: 421 DPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYE 480
Query: 481 ANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFVSKSSEEKRLS 540
ANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFVSKSSEEKRLS
Sbjct: 481 ANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFVSKSSEEKRLS 540
Query: 541 ISKFGPGDQVRASAQSSVRSNDSGIQQSSDDGRESLPSTVSANSLYEPEGERQDSSMFLD 600
ISKFGPGDQVRASAQSSVRSNDSGIQQSSDDGRESLPSTVSANSLYEPEGERQDSSMFLD
Sbjct: 541 ISKFGPGDQVRASAQSSVRSNDSGIQQSSDDGRESLPSTVSANSLYEPEGERQDSSMFLD 600
Query: 601 SKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFL 660
SKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFL
Sbjct: 601 SKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFL 660
Query: 661 LQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANA 720
LQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANA
Sbjct: 661 LQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANA 720
Query: 721 DIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF 778
DIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF
Sbjct: 721 DIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF 778
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 912 bits (2357), Expect = 0.0
Identities = 480/808 (59%), Positives = 593/808 (73%), Gaps = 64/808 (7%)
Query: 3 MTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNG 62
MTV+FEEC+KDSPRFRA ++EVE DV E+E KLDKLVKLC M++ GKA+ ++ F++G
Sbjct: 1 MTVEFEECVKDSPRFRATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSG 60
Query: 63 IRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKD 122
+RDL+Q D V+ L +F+DSLQE++N+H ILFDQ QRS++ QLQ+FVKED+RKFK+
Sbjct: 61 VRDLSQQCQGDTVISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFKE 120
Query: 123 AKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVLQS 182
KKQF+KV E+ E +LV+NAQ R++ HEVEEAT LT TRKCFRH+ALDYVLQINVLQ+
Sbjct: 121 TKKQFDKVREDLELSLVRNAQAPRHRPHEVEEATGALTLTRKCFRHLALDYVLQINVLQA 180
Query: 183 KRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKH 242
K++ EIL SMLSFM+A +FF QGY L +L PYMK L A+LD+LV+D+A EKREME+KH
Sbjct: 181 KKKFEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKH 240
Query: 243 STIQQK----DFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVY 298
+ IQQ+ DFS D+SK+E++VDA +G+VMEGYLFKRASNAFKTWNRRWFSIQN+QLVY
Sbjct: 241 AAIQQRTLLQDFSYDESKVEFDVDAPSGVVMEGYLFKRASNAFKTWNRRWFSIQNSQLVY 300
Query: 299 QKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQT 358
QKK KD TVVV+DLRLC+VK CEDIERRFCFEV+SPTKSCMLQADSEKLRQAW++AVQ
Sbjct: 301 QKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKLRQAWVQAVQA 360
Query: 359 SIATAYREKGDE--SEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCD 416
SIA+AYRE D SE+LD+ +SPST S+DS +++E+ +KGES LQRVQ + GN+ C D
Sbjct: 361 SIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGESVLQRVQSVAGNSQCGD 420
Query: 417 CGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVIN 476
CG DPRWASINLG+ LCIECSGIHRSLGVH SKVRSLTLD+WEPELLKLMCELGN +N
Sbjct: 421 CGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPELLKLMCELGNSAVN 480
Query: 477 RVYEANVEKMGIKKP-QPGQRQEKEAYIRAKYVERKFVDKYSI--SLSPPEQ---QKKFV 530
++YEA E G +KP RQ+KEA+I+ KYVE+KF+ K + +L P + QK
Sbjct: 481 QIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRKAPMAPALEAPRRWRVQKCLR 540
Query: 531 SKSSEE------------------------------KRLSI-------SKFGPGDQVRAS 553
SS +R S+ S F D A
Sbjct: 541 PHSSPRAPTARRKVRLEPVLPCVAALSSVGTLDRKFRRDSLFCPDELDSLFSYFDAGAAG 600
Query: 554 AQSSVRSNDSGIQQSSDDGRESLP--STVSANSLYEPEGERQDSSM-------------F 598
A S+DSG+ SSD + L S +S+ E EG + S
Sbjct: 601 AGPRSLSSDSGLGGSSDGSSDVLAFGSGSVVDSVTEEEGAESEESSGEADGDTEAEAWGL 660
Query: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLGGSLVTCE 658
D + L+PGL +RA+ ++LP +A ALAHGA+VNWA++E+ TPL+QAVLGGSL+ CE
Sbjct: 661 ADVRELHPGLLAHRAARARDLPALAAALAHGAEVNWADAEDEGKTPLVQAVLGGSLIVCE 720
Query: 659 FLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAA 718
FLLQNGA+VNQRD +GR PLHHAT+LG TGQVCLFLKRGA+QHA D+E +DPL+IAV+AA
Sbjct: 721 FLLQNGADVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAA 780
Query: 719 NADIVTLLRLARMNEEMRESEGLYGQPG 746
NADIVTLLRLARM EEMRE+E G PG
Sbjct: 781 NADIVTLLRLARMAEEMREAEAAPGPPG 808
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 736 bits (1900), Expect = 0.0
Identities = 403/783 (51%), Positives = 525/783 (67%), Gaps = 56/783 (7%)
Query: 1 MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFM 60
M + +DFEECLKDSPRFRA++E VE +V+ELE +L+KL+KL ++++G+ + A++ F+
Sbjct: 1 MTVKLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGTGLLESGRHYLAASRAFV 60
Query: 61 NGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKF 120
GI DLA+ + ++ L KF+ SL ++ H L D TQ +++ Q+Q VKE LR F
Sbjct: 61 VGICDLARLGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGF 120
Query: 121 KDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVL 180
++A++ F + +E E AL NA+V R + E EEA L R +R ALDY LQINV+
Sbjct: 121 REARRDFWRGAESLEAALTHNAEVPRRRAQEAEEAGAALRTARAGYRGRALDYALQINVI 180
Query: 181 QSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQ 240
+ KR+ +I++ +L + A F QG++ S L Y K+LGAQL +LV+++A+EKR+MEQ
Sbjct: 181 EDKRKFDIMEFVLRLVEAQATHFQQGHEELSRLSQYRKELGAQLHQLVLNSAREKRDMEQ 240
Query: 241 KHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFSIQNNQLVYQK 300
+H ++QK+ ++ + + G+VMEG+LFKRASNAFKTW+RRWF+IQ+NQLVYQK
Sbjct: 241 RHVLLKQKELGGEEPEPSLR-EGPGGLVMEGHLFKRASNAFKTWSRRWFTIQSNQLVYQK 299
Query: 301 KFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQTSI 360
K+KD TVVV+DLRLCTVK C D ERRFCFEVVS +KSC+LQADSE+L Q W+ AVQ+SI
Sbjct: 300 KYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLLQLWVSAVQSSI 359
Query: 361 ATAYRE-KGDESEKLDKKSSP-----STGSLDSGNESKEKLLKGES-ALQRVQCIPGNAS 413
A+A+ + + D+S + + S S +L SG ++ + G + +VQ + GNA
Sbjct: 360 ASAFSQARLDDSPRGPGQGSGHLAIGSAATLGSGGMARGREPGGVGHVVAQVQSVDGNAQ 419
Query: 414 CCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGND 473
CCDC P WASINLG+TLCI+CSGIHRSLGVHFSKVRSLTLD+WEPEL+KLMCELGN
Sbjct: 420 CCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNV 479
Query: 474 VINRVYEANVEKMGIKKPQPG-QRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFVSK 532
+IN++YEA VE M +KKP P RQEKEA+I AKYVE KKF++K
Sbjct: 480 IINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVE-----------------KKFLTK 522
Query: 533 SSEEKRLSISKFGPGDQVRASAQSSVRSNDSGIQQSSDDGRESLPSTVSANSLYEPEGER 592
E + + P Q + S+R P S S EP E
Sbjct: 523 LPEIRGRRGGRGRPRGQPPVPPKPSIR-----------------PRPGSLRSKPEPPSE- 564
Query: 593 QDSSMFLDSKHLNPGLQLYRAS-YEKNLPKMAEALAHGADVNWANSEENKATPLIQAVLG 651
D L+PG L+RAS + +LP MA+ALAHGADVNW N ++ ATPLIQA
Sbjct: 565 -------DLGSLHPGALLFRASGHPPSLPTMADALAHGADVNWVNGGQDNATPLIQATAA 617
Query: 652 GSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPL 711
SL+ CEFLLQNGANVNQ D GRGPLHHAT+LGHTG CLFLKRGA+ A D EG+DPL
Sbjct: 618 NSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDSEGRDPL 677
Query: 712 SIAVEAANADIVTLLRLARMNEEMRESEGLYGQPGDETYQDIFRDFSQMASNNPEKLNRF 771
+IA+E ANADIVTLLRLA+ MRE+E GQ GDETY DIFRDFS MAS++PEKL+R
Sbjct: 678 TIAMETANADIVTLLRLAK----MREAEAAQGQAGDETYLDIFRDFSLMASDDPEKLSRR 733
Query: 772 QQD 774
D
Sbjct: 734 SHD 736
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 184 bits (468), Expect = 2e-46
Identities = 147/527 (27%), Positives = 243/527 (46%), Gaps = 56/527 (10%)
Query: 19 AALEEVEGDVAELEL-KLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQ--YSSNDAV 75
AA+EE DV + L K+ K VK A+ +G A +Q+ + +D
Sbjct: 38 AAIEEAL-DVDRMVLYKMKKSVK---AINSSGLAHVENEEQYTQALEKFGGNCVCRDDPD 93
Query: 76 VETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFK-DAKKQFEKVSEEK 134
+ ++ KFS +E+ L I L + +K DL+ K D KK F+K ++
Sbjct: 94 LGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDY 153
Query: 135 ENALVKNAQVQRNKQHEVE------------EATNILTATRKCFRHIALDYVLQINVLQS 182
E + K +++ K+ + E + R+ F+ +Y+L++N ++
Sbjct: 154 ETKITK---IEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKI 210
Query: 183 KRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKH 242
K+ ++L++++ + +A FF G L P ++ L L + +E+R++ Q
Sbjct: 211 KKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLR 270
Query: 243 ST------IQQKDFSSDDSKLEYNV-----DAANGIVMEGYLFKRASNAFKTWNRRWFSI 291
++QK+ S Y++ + +G G L+K++ K W +R S+
Sbjct: 271 DILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSV 330
Query: 292 QNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQA 351
+N L + P + +L C VK + E + CF+++S ++ QA+ E+ Q
Sbjct: 331 KNGFLTISHGTANRPPAKL-NLLTCQVK--TNPEEKKCFDLISHDRTYHFQAEDEQECQI 387
Query: 352 WIKAVQTSIATAYRE--KGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIP 409
W+ +Q S A KGD++ TG N ++L K + VQ +
Sbjct: 388 WMSVLQNSKEEALNNAFKGDDN----------TGE----NNIVQELTK--EIISEVQRMT 431
Query: 410 GNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCE 469
GN CCDCG DP W S NLGI CIECSGIHR LGVH+S+++SLTLD L L
Sbjct: 432 GNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKN 491
Query: 470 LGNDVINRVYEANVEKMGIKKPQPG-QRQEKEAYIRAKYVERKFVDK 515
+GN N + E + KP PG ++ YI AKY+ER++ K
Sbjct: 492 IGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARK 538
Score = 40.0 bits (92), Expect = 0.008
Identities = 33/123 (26%), Positives = 60/123 (48%), Gaps = 10/123 (8%)
Query: 602 KHLNPGLQLY---RASYEKNLPKMAEALAHGADVN----WANSEENKATPL---IQAVLG 651
KH + +L+ A +++ + +A A G D+ AN E T L +++V
Sbjct: 539 KHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDR 598
Query: 652 GSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPL 711
SL +FL+QN N++++ +G LH+ + + + L L+ A+ +E G+ PL
Sbjct: 599 TSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPL 658
Query: 712 SIA 714
IA
Sbjct: 659 DIA 661
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 184 bits (468), Expect = 2e-46
Identities = 147/527 (27%), Positives = 243/527 (46%), Gaps = 56/527 (10%)
Query: 19 AALEEVEGDVAELEL-KLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQ--YSSNDAV 75
AA+EE DV + L K+ K VK A+ +G A +Q+ + +D
Sbjct: 38 AAIEEAL-DVDRMVLYKMKKSVK---AINSSGLAHVENEEQYTQALEKFGGNCVCRDDPD 93
Query: 76 VETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFK-DAKKQFEKVSEEK 134
+ ++ KFS +E+ L I L + +K DL+ K D KK F+K ++
Sbjct: 94 LGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDY 153
Query: 135 ENALVKNAQVQRNKQHEVE------------EATNILTATRKCFRHIALDYVLQINVLQS 182
E + K +++ K+ + E + R+ F+ +Y+L++N ++
Sbjct: 154 ETKITK---IEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKI 210
Query: 183 KRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKH 242
K+ ++L++++ + +A FF G L P ++ L L + +E+R++ Q
Sbjct: 211 KKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLR 270
Query: 243 ST------IQQKDFSSDDSKLEYNV-----DAANGIVMEGYLFKRASNAFKTWNRRWFSI 291
++QK+ S Y++ + +G G L+K++ K W +R S+
Sbjct: 271 DILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSV 330
Query: 292 QNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQA 351
+N L + P + +L C VK + E + CF+++S ++ QA+ E+ Q
Sbjct: 331 KNGFLTISHGTANRPPAKL-NLLTCQVK--TNPEEKKCFDLISHDRTYHFQAEDEQECQI 387
Query: 352 WIKAVQTSIATAYRE--KGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIP 409
W+ +Q S A KGD++ TG N ++L K + VQ +
Sbjct: 388 WMSVLQNSKEEALNNAFKGDDN----------TGE----NNIVQELTK--EIISEVQRMT 431
Query: 410 GNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCE 469
GN CCDCG DP W S NLGI CIECSGIHR LGVH+S+++SLTLD L L
Sbjct: 432 GNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKN 491
Query: 470 LGNDVINRVYEANVEKMGIKKPQPG-QRQEKEAYIRAKYVERKFVDK 515
+GN N + E + KP PG ++ YI AKY+ER++ K
Sbjct: 492 IGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARK 538
Score = 40.0 bits (92), Expect = 0.008
Identities = 33/123 (26%), Positives = 60/123 (48%), Gaps = 10/123 (8%)
Query: 602 KHLNPGLQLY---RASYEKNLPKMAEALAHGADVN----WANSEENKATPL---IQAVLG 651
KH + +L+ A +++ + +A A G D+ AN E T L +++V
Sbjct: 539 KHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDR 598
Query: 652 GSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPL 711
SL +FL+QN N++++ +G LH+ + + + L L+ A+ +E G+ PL
Sbjct: 599 TSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPL 658
Query: 712 SIA 714
IA
Sbjct: 659 DIA 661
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 184 bits (467), Expect = 3e-46
Identities = 145/558 (25%), Positives = 249/558 (44%), Gaps = 44/558 (7%)
Query: 15 PRFRAAL----EEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDL--AQ 68
PR+R A E +EGD A L+ ++ K A+ +G +Q+ + L +
Sbjct: 32 PRYRGAALAREEILEGDQAILQ----RIKKAVRAIHSSGLGHVENEEQYREAVESLGNSH 87
Query: 69 YSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFK-DAKKQF 127
S N + T + +E+ L + L + +K LR + D+KKQ
Sbjct: 88 LSQNSHELSTGFLNLAVFTREVAALFKNLIQNLNNIVSFPLDSLMKGQLRDGRQDSKKQL 147
Query: 128 EKVSEEKENALVKNAQVQRNKQHEVE----EATNILTATRKCFRHIALDYVLQINVLQSK 183
EK ++ E + K + +R++ E + R+ F+ +Y+L+ Q K
Sbjct: 148 EKAWKDYEAKMAK-LEKERDRARVTGGIPGEVAQDMQRERRIFQLHMCEYLLKAGESQMK 206
Query: 184 RRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRL-------------VVD 230
+ + L+S++ F +A FF G+ L P+++ L A + L + D
Sbjct: 207 QGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFIEKLAASVHALHQAQEDELQKLTQLRD 266
Query: 231 AAKEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWFS 290
+ + ++E + + +K+ S ++ + G G+L+K++ + W +R
Sbjct: 267 SLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCG 326
Query: 291 IQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQ 350
++ L + P V L L T + + E + CF++V+ ++ QA+ E +
Sbjct: 327 VKYGCLTISHSTINRPPV---KLTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHECE 383
Query: 351 AWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPG 410
AW+ +Q S +++ S L + S+ GS S E + + V+ PG
Sbjct: 384 AWVSVLQNS-----KDEALSSAFLGEPSA-GPGSWGSAGHDGEPHDLTKLLIAEVKSRPG 437
Query: 411 NASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCEL 470
N+ CCDCG ADP W S NLG+ CI+CSG+HR LGV FS+++SLTLD P L L +
Sbjct: 438 NSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSELLLALNM 497
Query: 471 GNDVINRVYEANVEKMGIKKPQ-PGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKF 529
GN N V EA + G KP + YI AKYVE +F + + PE Q+ +
Sbjct: 498 GNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCT-----PEPQRLW 552
Query: 530 VSKSSEEKRLSISKFGPG 547
+ + + + F G
Sbjct: 553 TAICNRDLLSVLEAFANG 570
Score = 39.7 bits (91), Expect = 0.011
Identities = 31/129 (24%), Positives = 56/129 (43%), Gaps = 7/129 (5%)
Query: 609 QLYRASYEKNLPKMAEALAHGADVNWANSEENKATP-------LIQAVLGGSLVTCEFLL 661
+L+ A ++L + EA A+G D + P ++ SL +F++
Sbjct: 550 RLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFII 609
Query: 662 QNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANAD 721
QNG +++ + G LH+A + + L LK A +E G+ L IA + + +
Sbjct: 610 QNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKE 669
Query: 722 IVTLLRLAR 730
LL A+
Sbjct: 670 CEELLEQAQ 678
>gi|46094081 development and differentiation enhancing factor 1
[Homo sapiens]
Length = 1129
Score = 180 bits (456), Expect = 5e-45
Identities = 129/458 (28%), Positives = 213/458 (46%), Gaps = 38/458 (8%)
Query: 78 TSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFK-DAKKQFEKVSEEKEN 136
T+ KFS +E+ L ++ L + +K DL+ K D KK F+K ++ E
Sbjct: 116 TAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYET 175
Query: 137 ALVKNAQVQRN--KQHEV-------EEATNILTATRKCFRHIALDYVLQINVLQSKRRSE 187
K + +R KQH + E + R+ F+ +Y++++N +++K+ +
Sbjct: 176 KFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVD 235
Query: 188 ILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKHSTI-- 245
+L++++ + +A FF G +L Y++ L A L + +EK+++ I
Sbjct: 236 LLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKS 295
Query: 246 -----QQKDFSSDDSKLEYNVDAAN---GIVMEGYLFKRASNAFKTWNRRWFSIQNNQLV 297
Q++D S + N G +GYL K++ K W RR S++N L
Sbjct: 296 SLQLDQKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILT 355
Query: 298 YQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQ 357
+ + +L C VK + E + F+++S ++ QA+ E+ AWI +
Sbjct: 356 ISHATSNRQPAKL-NLLTCQVK--PNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLT 412
Query: 358 TSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDC 417
S K + + G +G S E L K + ++ VQ +PGN CCDC
Sbjct: 413 NS-------------KEEALTMAFRGEQSAGENSLEDLTK--AIIEDVQRLPGNDICCDC 457
Query: 418 GLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINR 477
G ++P W S NLGI CIECSGIHR +GVH S+++SL LD L L +GN+ N
Sbjct: 458 GSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFND 517
Query: 478 VYEANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDK 515
+ EAN+ K ++ YI AKYV+ +F K
Sbjct: 518 IMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRK 555
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 177 bits (450), Expect = 3e-44
Identities = 143/559 (25%), Positives = 245/559 (43%), Gaps = 55/559 (9%)
Query: 15 PRFRAAL----EEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDL--AQ 68
PR+R A E +EGD A L+ ++ K A+ +G +Q+ + L +
Sbjct: 32 PRYRGAALAREEILEGDQAILQ----RIKKAVRAIHSSGLGHVENEEQYREAVESLGNSH 87
Query: 69 YSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDAKKQF- 127
S N + T + +E+ L + L + +K LR + A
Sbjct: 88 LSQNSHELSTGFLNLAVFTREVAALFKNLIQNLNNIVSFPLDSLMKGQLRDGRQASLSLG 147
Query: 128 --EKVSEEKENALVKNA---QVQRNKQHEVEEATNILTATRKCFRHIALDYVLQINVLQS 182
K+ +E++ A V +V ++ Q E R+ F+ +Y+L+ Q
Sbjct: 148 SRAKLEKERDRARVTGGIPGEVAQDMQRE-----------RRIFQLHMCEYLLKAGESQM 196
Query: 183 KRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRL-------------VV 229
K+ + L+S++ F +A FF G+ L P+++ L A + L +
Sbjct: 197 KQGPDFLQSLIKFFHAQHNFFQDGWKAAQSLFPFIEKLAASVHALHQAQEDELQKLTQLR 256
Query: 230 DAAKEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKTWNRRWF 289
D+ + ++E + + +K+ S ++ + G G+L+K++ + W +R
Sbjct: 257 DSLRGTLQLESREEHLSRKNSGCGYSIHQHQGNKQFGTEKVGFLYKKSDGIRRVWQKRKC 316
Query: 290 SIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLR 349
++ L + P V L L T + + E + CF++V+ ++ QA+ E
Sbjct: 317 GVKYGCLTISHSTINRPPV---KLTLLTCQVRPNPEEKKCFDLVTHNRTYHFQAEDEHEC 373
Query: 350 QAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIP 409
+AW+ +Q S +++ S L + S+ GS S E + + V+ P
Sbjct: 374 EAWVSVLQNS-----KDEALSSAFLGEPSA-GPGSWGSAGHDGEPHDLTKLLIAEVKSRP 427
Query: 410 GNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCE 469
GN+ CCDCG ADP W S NLG+ CI+CSG+HR LGV FS+++SLTLD P L L
Sbjct: 428 GNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSELLLALN 487
Query: 470 LGNDVINRVYEANVEKMGIKKPQ-PGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKK 528
+GN N V EA + G KP + YI AKYVE +F + + PE Q+
Sbjct: 488 MGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAKYVEHRFARRCT-----PEPQRL 542
Query: 529 FVSKSSEEKRLSISKFGPG 547
+ + + + + F G
Sbjct: 543 WTAICNRDLLSVLEAFANG 561
Score = 39.7 bits (91), Expect = 0.011
Identities = 31/129 (24%), Positives = 56/129 (43%), Gaps = 7/129 (5%)
Query: 609 QLYRASYEKNLPKMAEALAHGADVNWANSEENKATP-------LIQAVLGGSLVTCEFLL 661
+L+ A ++L + EA A+G D + P ++ SL +F++
Sbjct: 541 RLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVLHLAVKVANQASLPLVDFII 600
Query: 662 QNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANAD 721
QNG +++ + G LH+A + + L LK A +E G+ L IA + + +
Sbjct: 601 QNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKE 660
Query: 722 IVTLLRLAR 730
LL A+
Sbjct: 661 CEELLEQAQ 669
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 132 bits (333), Expect = 9e-31
Identities = 76/186 (40%), Positives = 111/186 (59%), Gaps = 21/186 (11%)
Query: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388
F +VS T ++ +A + + R AW++A+Q+ I + + +SS S L S
Sbjct: 388 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSC---------ESSKSKSQLTSQ 438
Query: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448
+E+ ALQ +Q + GNA C DC +P+WAS+NLG+ +CIECSGIHRSLG
Sbjct: 439 SEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRL 490
Query: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKP-QPGQRQEKEAYIRAKY 507
S+VRSL LD W EL K+M +GND+ N ++E + G KP + R+EKE +IR+KY
Sbjct: 491 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS--SQGRTKPTEKSTREEKERWIRSKY 548
Query: 508 VERKFV 513
E+ F+
Sbjct: 549 EEKLFL 554
Score = 38.5 bits (88), Expect = 0.024
Identities = 28/85 (32%), Positives = 42/85 (49%), Gaps = 2/85 (2%)
Query: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
L L+ G QL RA+ +++L LAHG+ +VN E + T L A G++V
Sbjct: 557 LPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL 616
Query: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681
+ L+ G +V RD G L +A
Sbjct: 617 AQLLIWYGVDVMARDAHGNTALTYA 641
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 132 bits (332), Expect = 1e-30
Identities = 75/186 (40%), Positives = 110/186 (59%), Gaps = 21/186 (11%)
Query: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388
F +VS T ++C +A + + R AW++A+Q+ I + + +SS S L S
Sbjct: 275 FMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSC---------ESSKSKSQLTSQ 325
Query: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448
+E+ ALQ +Q + GN+ C DC +P+WAS+NLG+ +CIECSGIHRSLG
Sbjct: 326 SEAM--------ALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRL 377
Query: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQ-PGQRQEKEAYIRAKY 507
S+VRSL LD W EL K+M +GND+ N ++E + G KP R+EKE +IR+KY
Sbjct: 378 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS--SQGQTKPSIESTREEKERWIRSKY 435
Query: 508 VERKFV 513
+ F+
Sbjct: 436 EHKLFL 441
Score = 36.2 bits (82), Expect = 0.12
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
L L+ G L RA+ +++L LAHG+ +VN E + T L A G++V
Sbjct: 444 LPCTELSLGQHLLRATADEDLRTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL 503
Query: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681
+ L+ G +V RD G L +A
Sbjct: 504 AQLLIWYGVDVMARDAHGNTALTYA 528
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 131 bits (330), Expect = 2e-30
Identities = 76/186 (40%), Positives = 111/186 (59%), Gaps = 21/186 (11%)
Query: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388
F +VS T ++ +A + + R AW++A+Q+ I + + +SS S L S
Sbjct: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSC---------ESSKSKSQLTSQ 461
Query: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448
+E+ ALQ +Q + GNA C DC +P+WAS+NLG+ +CIECSGIHRSLG H
Sbjct: 462 SEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHL 513
Query: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKP-QPGQRQEKEAYIRAKY 507
S+VRSL LD W EL K+M + ND+ N ++E + G KP + R+EKE +IR+KY
Sbjct: 514 SRVRSLELDDWPVELRKVMSSIVNDLANSIWEGS--SQGQTKPSEKSTREEKERWIRSKY 571
Query: 508 VERKFV 513
E+ F+
Sbjct: 572 EEKLFL 577
Score = 39.3 bits (90), Expect = 0.014
Identities = 41/143 (28%), Positives = 62/143 (43%), Gaps = 15/143 (10%)
Query: 549 QVRASAQSSVRSNDSGIQQSSDDGRESLPSTVSANSLYEPEGERQDSSMFLDSKHLNP-- 606
++R S V + I + S G ++ PS S E ER S + + L P
Sbjct: 527 ELRKVMSSIVNDLANSIWEGSSQG-QTKPSEKSTRE----EKERWIRSKYEEKLFLAPLP 581
Query: 607 ------GLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVTCE 658
G QL RA+ +++L LAHG+ +VN E + T L A G++V +
Sbjct: 582 CTELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQ 641
Query: 659 FLLQNGANVNQRDVQGRGPLHHA 681
L+ G +V RD G L +A
Sbjct: 642 LLIWYGVDVMARDAHGNTALTYA 664
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 131 bits (329), Expect = 3e-30
Identities = 75/186 (40%), Positives = 111/186 (59%), Gaps = 21/186 (11%)
Query: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388
F +VS T ++ +A + + R AW++A+Q+ I + + +SS S L S
Sbjct: 388 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSC---------ESSKSKSQLTSQ 438
Query: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448
+++ ALQ +Q + GNA C DC +P+WAS+NLG+ +CIECSGIHRSLG
Sbjct: 439 SKAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRL 490
Query: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKP-QPGQRQEKEAYIRAKY 507
S+VRSL LD W EL K+M +GND+ N ++E + G KP + R+EKE +IR+KY
Sbjct: 491 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS--SQGQTKPSEKSTREEKERWIRSKY 548
Query: 508 VERKFV 513
E+ F+
Sbjct: 549 EEKLFL 554
Score = 38.5 bits (88), Expect = 0.024
Identities = 28/85 (32%), Positives = 42/85 (49%), Gaps = 2/85 (2%)
Query: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
L L+ G QL RA+ +++L LAHG+ +VN E + T L A G++V
Sbjct: 557 LPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL 616
Query: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681
+ L+ G +V RD G L +A
Sbjct: 617 AQLLIWYGVDVMARDAHGNTALTYA 641
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 130 bits (328), Expect = 4e-30
Identities = 75/186 (40%), Positives = 110/186 (59%), Gaps = 21/186 (11%)
Query: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388
F +VS T ++ +A + + R AW++A+Q+ I + + +SS S L S
Sbjct: 388 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSC---------ESSKSKSQLTSQ 438
Query: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448
+E+ ALQ +Q + GNA C DC +P+WAS+NLG+ +CIECSGIH SLG
Sbjct: 439 SEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRL 490
Query: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKP-QPGQRQEKEAYIRAKY 507
S+VRSL LD W EL K+M +GND+ N ++E + G KP + R+EKE +IR+KY
Sbjct: 491 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS--SQGQTKPSEKSTREEKERWIRSKY 548
Query: 508 VERKFV 513
E+ F+
Sbjct: 549 EEKLFL 554
Score = 35.4 bits (80), Expect = 0.20
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
L L+ G QL A+ +++L LAHG+ +VN E + T L A G++V
Sbjct: 557 LPCTELSLGQQLLWATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL 616
Query: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681
+ L+ G +V RD G L +A
Sbjct: 617 AQLLIWYGVDVMARDAHGNTALTYA 641
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 130 bits (327), Expect = 5e-30
Identities = 82/211 (38%), Positives = 112/211 (53%), Gaps = 29/211 (13%)
Query: 322 EDIERRFCFEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSP 380
E+ E F F VVS T ++ +A + + R+ W+++VQ I
Sbjct: 601 EEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILA------------------ 642
Query: 381 STGSLDSGNESKEKLLKGES----ALQRVQCIPGNASCCDCGLADPRWASINLGITLCIE 436
SL +K+K G A+Q V+ + GN+ C DC +P WAS+NLG +CIE
Sbjct: 643 ---SLQGCRSAKDKTRLGNQNAALAVQAVRTVRGNSFCIDCDAPNPDWASLNLGALMCIE 699
Query: 437 CSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQPGQ- 495
CSGIHR LG H S+VRSL LD W PELL +M +GN + N V+E + G KP P
Sbjct: 700 CSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALG--GYSKPGPDAC 757
Query: 496 RQEKEAYIRAKYVERKFVDKYSISLSPPEQQ 526
R+EKE +IRAKY ++ F+ S P QQ
Sbjct: 758 REEKERWIRAKYEQKLFLAPLPSSDVPLGQQ 788
Score = 37.7 bits (86), Expect = 0.041
Identities = 29/101 (28%), Positives = 47/101 (46%), Gaps = 2/101 (1%)
Query: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
L S + G QL RA E +L + LAHG+ +VN + + T L + ++V
Sbjct: 778 LPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVF 837
Query: 657 CEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRG 697
+ L+ G +V RD +G PL +A G + ++ G
Sbjct: 838 TQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHG 878
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 129 bits (325), Expect = 8e-30
Identities = 75/186 (40%), Positives = 109/186 (58%), Gaps = 21/186 (11%)
Query: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388
F +VS T ++ +A + + R AW++A+Q+ I + + KSS S L S
Sbjct: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSC---------KSSKSKSQLTSQ 461
Query: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448
+E+ ALQ +Q + GNA C DC +P+WAS+NLG+ +CIECSGIHRS G
Sbjct: 462 SEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRL 513
Query: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQ-PGQRQEKEAYIRAKY 507
S+VRSL LD W EL K+M +GN++ N ++E + G KP R+EKE +IR+KY
Sbjct: 514 SRVRSLELDDWPVELRKVMSSIGNELANSIWEGS--SQGQTKPSIKSTREEKEWWIRSKY 571
Query: 508 VERKFV 513
E+ F+
Sbjct: 572 EEKLFL 577
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 129 bits (325), Expect = 8e-30
Identities = 75/186 (40%), Positives = 109/186 (58%), Gaps = 21/186 (11%)
Query: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388
F +VS T ++ +A + + R AW++A+Q+ I + + KSS S L S
Sbjct: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSC---------KSSKSKSQLTSQ 461
Query: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448
+E+ ALQ +Q + GNA C DC +P+WAS+NLG+ +CIECSGIHRS G
Sbjct: 462 SEAM--------ALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRL 513
Query: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQ-PGQRQEKEAYIRAKY 507
S+VRSL LD W EL K+M +GN++ N ++E + G KP R+EKE +IR+KY
Sbjct: 514 SRVRSLELDDWPVELRKVMSSIGNELANSIWEGS--SQGQTKPSIKSTREEKEWWIRSKY 571
Query: 508 VERKFV 513
E+ F+
Sbjct: 572 EEKLFL 577
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 129 bits (324), Expect = 1e-29
Identities = 79/204 (38%), Positives = 119/204 (58%), Gaps = 21/204 (10%)
Query: 325 ERRFCFEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTG 383
E F F +VS T ++ +A S + R AW++A+++ I + + ES K+ ++
Sbjct: 873 EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQ--CCESSKVKLRT----- 925
Query: 384 SLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRS 443
DS +E+ A+Q ++ GN+ C DCG +P WAS+NLG +CIECSGIHR+
Sbjct: 926 --DSQSEAV--------AIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRN 975
Query: 444 LGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKP-QPGQRQEKEAY 502
LG H S+VRSL LD W EL ++ +GND NRV+E++ G KP + R+E+E++
Sbjct: 976 LGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTR--GRAKPSRDSSREERESW 1033
Query: 503 IRAKYVERKFVDKYSISLSPPEQQ 526
IRAKY + F+ S S P +Q
Sbjct: 1034 IRAKYEQLLFLAPLSTSEEPLGRQ 1057
Score = 33.1 bits (74), Expect = 1.0
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 7/96 (7%)
Query: 635 ANSEENKATPLIQAVLGGSLVTCEFLLQNGAN----VNQRDVQGRGPLHHATVLGHTGQV 690
+ SEE L AV + T LL + + + D Q R PLH A L H
Sbjct: 1048 STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVIT 1107
Query: 691 CLFLKRGANQHATDEEGKDPLSIAVEAAN---ADIV 723
L L GA+ A D +G+ L A +A + ADI+
Sbjct: 1108 QLLLWYGADVAARDAQGRTALFYARQAGSQLCADIL 1143
Score = 31.6 bits (70), Expect = 2.9
Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 4/87 (4%)
Query: 607 GLQLYRASYEKNLPKMAEALAHGADVNWANSEENKA--TPLIQAVLGGSLVTCEFLLQNG 664
G QL+ A +++ + LAH S E+ +PL A +V + LL G
Sbjct: 1055 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 1114
Query: 665 ANVNQRDVQGRGPLHHATVLGHTGQVC 691
A+V RD QGR L +A G Q+C
Sbjct: 1115 ADVAARDAQGRTALFYARQAG--SQLC 1139
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 129 bits (324), Expect = 1e-29
Identities = 79/204 (38%), Positives = 119/204 (58%), Gaps = 21/204 (10%)
Query: 325 ERRFCFEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTG 383
E F F +VS T ++ +A S + R AW++A+++ I + + ES K+ ++
Sbjct: 517 EENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQ--CCESSKVKLRT----- 569
Query: 384 SLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRS 443
DS +E+ A+Q ++ GN+ C DCG +P WAS+NLG +CIECSGIHR+
Sbjct: 570 --DSQSEAV--------AIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRN 619
Query: 444 LGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKP-QPGQRQEKEAY 502
LG H S+VRSL LD W EL ++ +GND NRV+E++ G KP + R+E+E++
Sbjct: 620 LGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTR--GRAKPSRDSSREERESW 677
Query: 503 IRAKYVERKFVDKYSISLSPPEQQ 526
IRAKY + F+ S S P +Q
Sbjct: 678 IRAKYEQLLFLAPLSTSEEPLGRQ 701
Score = 33.1 bits (74), Expect = 1.0
Identities = 31/96 (32%), Positives = 42/96 (43%), Gaps = 7/96 (7%)
Query: 635 ANSEENKATPLIQAVLGGSLVTCEFLLQNGAN----VNQRDVQGRGPLHHATVLGHTGQV 690
+ SEE L AV + T LL + + + D Q R PLH A L H
Sbjct: 692 STSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVIT 751
Query: 691 CLFLKRGANQHATDEEGKDPLSIAVEAAN---ADIV 723
L L GA+ A D +G+ L A +A + ADI+
Sbjct: 752 QLLLWYGADVAARDAQGRTALFYARQAGSQLCADIL 787
Score = 31.6 bits (70), Expect = 2.9
Identities = 28/87 (32%), Positives = 40/87 (45%), Gaps = 4/87 (4%)
Query: 607 GLQLYRASYEKNLPKMAEALAHGADVNWANSEENKA--TPLIQAVLGGSLVTCEFLLQNG 664
G QL+ A +++ + LAH S E+ +PL A +V + LL G
Sbjct: 699 GRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYG 758
Query: 665 ANVNQRDVQGRGPLHHATVLGHTGQVC 691
A+V RD QGR L +A G Q+C
Sbjct: 759 ADVAARDAQGRTALFYARQAG--SQLC 783
>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
Length = 786
Score = 129 bits (324), Expect = 1e-29
Identities = 102/404 (25%), Positives = 190/404 (47%), Gaps = 48/404 (11%)
Query: 5 VDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIR 64
++F +C DSP FR + E ++ + +L+K +I K+ VA ++F + +R
Sbjct: 6 LEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLR 65
Query: 65 DLAQYSSNDAV------VETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLR 118
D DAV ++ SL +FS+ L+ + I+ ++ L+ F KE L
Sbjct: 66 DFKFEFIGDAVTDDERCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLG 125
Query: 119 KFKDAKKQFEKVSEEKENALVKNAQVQ-RNKQHEVEEATNILTATRKCFRHIALDYVLQI 177
K+ KK+F+K +E+ + + K+ + + K ++EA + R+ F ++L+YV ++
Sbjct: 126 AVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHLQEADIQVEQNRQHFYELSLEYVCKL 185
Query: 178 NVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKRE 237
+Q +++ E ++ MLSF F+HQG++L + Y +L + + E
Sbjct: 186 QEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFEGTRSE 245
Query: 238 MEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLF---KRASNAFKTWNRRWFSIQNN 294
+E+ + I+Q + D K A+ EGYL+ KR + +W + +
Sbjct: 246 VEELMNKIRQ---NPKDHK------RASQFTAEGYLYVQEKRPAPFGSSWVKHY------ 290
Query: 295 QLVYQKKFKDNPTVVVED-------------LRLCTVKHCEDIERRFCFEVVS---PTKS 338
+Y+K K + E L+ CT +H + I+RRFCF++ + P S
Sbjct: 291 -CMYRKAAKKFNMIPFEHRSGGKLGDGEVFFLKECTKRHTDSIDRRFCFDIEAADRPGVS 349
Query: 339 CMLQADSEKLRQAWI------KAVQTSIATAYREKGDESEKLDK 376
+QA SE+ R+ W+ +A+ S TA + + + +LDK
Sbjct: 350 LTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDK 393
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 129 bits (324), Expect = 1e-29
Identities = 75/194 (38%), Positives = 114/194 (58%), Gaps = 21/194 (10%)
Query: 322 EDIERRFCFEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSP 380
E+ E F F +VS T ++ +A + + R AW++A+++ I + + +SS
Sbjct: 495 EEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSC---------ESSK 545
Query: 381 STGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGI 440
+ L S +E+ ALQ ++ + GN+ C DC +P WAS+NLG +CIECSGI
Sbjct: 546 NKSRLTSQSEAM--------ALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGI 597
Query: 441 HRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQ-PGQRQEK 499
HR+LG H S+VRSL LD W EL+K+M +GN++ N V+E + G KP R+EK
Sbjct: 598 HRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEES--SQGRTKPSVDSTREEK 655
Query: 500 EAYIRAKYVERKFV 513
E +IRAKY ++ F+
Sbjct: 656 ERWIRAKYEQKLFL 669
Score = 36.6 bits (83), Expect = 0.092
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
L L+ G L RA+ +++L LAHG+ +VN E + T L A G++V
Sbjct: 672 LPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVL 731
Query: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681
+ L+ G +V RD G L +A
Sbjct: 732 AQLLIWYGVDVTARDAHGNTALAYA 756
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 129 bits (324), Expect = 1e-29
Identities = 75/194 (38%), Positives = 114/194 (58%), Gaps = 21/194 (10%)
Query: 322 EDIERRFCFEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSP 380
E+ E F F +VS T ++ +A + + R AW++A+++ I + + +SS
Sbjct: 548 EEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSC---------ESSK 598
Query: 381 STGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGI 440
+ L S +E+ ALQ ++ + GN+ C DC +P WAS+NLG +CIECSGI
Sbjct: 599 NKSRLTSQSEAM--------ALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGI 650
Query: 441 HRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQ-PGQRQEK 499
HR+LG H S+VRSL LD W EL+K+M +GN++ N V+E + G KP R+EK
Sbjct: 651 HRNLGTHLSRVRSLDLDDWPVELIKVMSSIGNELANSVWEES--SQGRTKPSVDSTREEK 708
Query: 500 EAYIRAKYVERKFV 513
E +IRAKY ++ F+
Sbjct: 709 ERWIRAKYEQKLFL 722
Score = 36.6 bits (83), Expect = 0.092
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
L L+ G L RA+ +++L LAHG+ +VN E + T L A G++V
Sbjct: 725 LPCTELSLGQHLLRATADEDLRTAILLLAHGSRDEVNETCGEGDGRTALHLACRKGNVVL 784
Query: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681
+ L+ G +V RD G L +A
Sbjct: 785 AQLLIWYGVDVTARDAHGNTALAYA 809
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 127 bits (320), Expect = 3e-29
Identities = 75/186 (40%), Positives = 109/186 (58%), Gaps = 21/186 (11%)
Query: 330 FEVVSPT-KSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSG 388
F +VS T ++ +A + + R AW++A+Q+ I + + +SS S L S
Sbjct: 411 FMIVSATGQTWHFEATTYEERDAWVQAIQSQILASLQSC---------ESSKSKSQLTSQ 461
Query: 389 NESKEKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHF 448
+E+ ALQ +Q + GNA C D +P+WAS+NLG+ +CIECSGIHRSLG
Sbjct: 462 SEAM--------ALQSIQNMRGNAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRL 513
Query: 449 SKVRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQ-PGQRQEKEAYIRAKY 507
S+VRSL LD W EL K+M +GND+ N ++E + G KP R+EKE +IR+KY
Sbjct: 514 SRVRSLELDDWPVELRKVMSSIGNDLANSIWEGS--SQGQTKPSVKSTREEKERWIRSKY 571
Query: 508 VERKFV 513
E+ F+
Sbjct: 572 EEKLFL 577
Score = 36.6 bits (83), Expect = 0.092
Identities = 27/85 (31%), Positives = 41/85 (48%), Gaps = 2/85 (2%)
Query: 599 LDSKHLNPGLQLYRASYEKNLPKMAEALAHGA--DVNWANSEENKATPLIQAVLGGSLVT 656
L L+ G L RA+ +++L LAHG+ +VN E + T L A G++V
Sbjct: 580 LPCTELSLGQHLLRATADEDLQTAILLLAHGSREEVNETCGEGDGCTALHLACRKGNVVL 639
Query: 657 CEFLLQNGANVNQRDVQGRGPLHHA 681
+ L+ G +V RD G L +A
Sbjct: 640 AQLLIWYGVDVMARDAHGNTALTYA 664
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 121 bits (303), Expect = 3e-27
Identities = 102/441 (23%), Positives = 198/441 (44%), Gaps = 31/441 (7%)
Query: 5 VDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIR 64
++F +C DSP FR L+ E ++ + + +L+K ++I K A ++F + +
Sbjct: 6 LEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLN 65
Query: 65 DLAQYSSNDA------VVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLR 118
+ DA + SL +F+ L+ + + + + + L+ F KE +
Sbjct: 66 EFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIG 125
Query: 119 KFKDAKKQFEKVSEEKENALVKNAQVQ-RNKQHEVEEATNILTATRKCFRHIALDYVLQI 177
K+AKK+++K +E+ L K+ + + K+ +++EA + + R+ F ++L+YV ++
Sbjct: 126 AAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKV 185
Query: 178 NVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKRE 237
+Q ++ E ++ +L+F+ F+H GY+L KD G +L + +
Sbjct: 186 QEVQERKMFEFVEPLLAFLQGLFTFYHHGYEL-------AKDFGDFKTQLTISIQNTRNR 238
Query: 238 MEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKT-WNRRWFSIQNNQL 296
E S ++ ++ LE+ + MEGYL+ + F T W + + + Q +
Sbjct: 239 FEGTRSEVESLMKKMKENPLEHK--TISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSK 296
Query: 297 VY------QK---KFKDNPTVVVEDLRLCTVKHCEDIERRFCFEV--VSPTKSCMLQADS 345
QK K ++ +V+ L+ CT + + IE+RFCF+V V +QA S
Sbjct: 297 QITMVPFDQKSGGKGGEDESVI---LKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALS 353
Query: 346 EKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRV 405
E+ R+ W++A+ K +SE + S + + E E L R+
Sbjct: 354 EEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRI 413
Query: 406 QCIPGNASCCDCGLADPRWAS 426
+ L DP+ AS
Sbjct: 414 VGVNSRVQKLLSVLMDPKTAS 434
>gi|7662208 GTPase regulator associated with the focal adhesion
kinase pp125 isoform a [Homo sapiens]
Length = 814
Score = 121 bits (303), Expect = 3e-27
Identities = 102/441 (23%), Positives = 198/441 (44%), Gaps = 31/441 (7%)
Query: 5 VDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIR 64
++F +C DSP FR L+ E ++ + + +L+K ++I K A ++F + +
Sbjct: 6 LEFSDCCLDSPHFRETLKSHEAELDKTNKFIKELIKDGKSLISALKNLSSAKRKFADSLN 65
Query: 65 DLAQYSSNDA------VVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLR 118
+ DA + SL +F+ L+ + + + + + L+ F KE +
Sbjct: 66 EFKFQCIGDAETDDEMCIARSLQEFATVLRNLEDERIRMIENASEVLITPLEKFRKEQIG 125
Query: 119 KFKDAKKQFEKVSEEKENALVKNAQVQ-RNKQHEVEEATNILTATRKCFRHIALDYVLQI 177
K+AKK+++K +E+ L K+ + + K+ +++EA + + R+ F ++L+YV ++
Sbjct: 126 AAKEAKKKYDKETEKYCGILEKHLNLSSKKKESQLQEADSQVDLVRQHFYEVSLEYVFKV 185
Query: 178 NVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKRE 237
+Q ++ E ++ +L+F+ F+H GY+L KD G +L + +
Sbjct: 186 QEVQERKMFEFVEPLLAFLQGLFTFYHHGYEL-------AKDFGDFKTQLTISIQNTRNR 238
Query: 238 MEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFKT-WNRRWFSIQNNQL 296
E S ++ ++ LE+ + MEGYL+ + F T W + + + Q +
Sbjct: 239 FEGTRSEVESLMKKMKENPLEHK--TISPYTMEGYLYVQEKRHFGTSWVKHYCTYQRDSK 296
Query: 297 VY------QK---KFKDNPTVVVEDLRLCTVKHCEDIERRFCFEV--VSPTKSCMLQADS 345
QK K ++ +V+ L+ CT + + IE+RFCF+V V +QA S
Sbjct: 297 QITMVPFDQKSGGKGGEDESVI---LKSCTRRKTDSIEKRFCFDVEAVDRPGVITMQALS 353
Query: 346 EKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRV 405
E+ R+ W++A+ K +SE + S + + E E L R+
Sbjct: 354 EEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAVETRGINEQGLYRI 413
Query: 406 QCIPGNASCCDCGLADPRWAS 426
+ L DP+ AS
Sbjct: 414 VGVNSRVQKLLSVLMDPKTAS 434
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 114 bits (284), Expect = 5e-25
Identities = 94/375 (25%), Positives = 177/375 (47%), Gaps = 32/375 (8%)
Query: 4 TVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGI 63
T++F + DSP FR L+ E ++ + +L+K +I + +A ++F +
Sbjct: 5 TLEFSDSYLDSPDFRERLQCHEIELERTNKFIKELIKDGSLLIGALRNLSMAVQKFSQSL 64
Query: 64 RDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIK-------AQLQNFVKED 116
+D DA + ++ + SL+E + ++ +R I+ A L+ F KE
Sbjct: 65 QDFQFECIGDAETDDEIS-IAQSLKEFARLLIAVEEERRRLIQNANDVLIAPLEKFRKEQ 123
Query: 117 LRKFKDAKKQFEKVSEEKENALVKNAQVQ-RNKQHEVEEATNILTATRKCFRHIALDYVL 175
+ KD KK+F+K SE+ + L K+ + + K+ ++EA + + F +L+YV
Sbjct: 124 IGAAKDGKKKFDKESEKYYSILEKHLNLSAKKKESHLQEADTQIDREHQNFYEASLEYVF 183
Query: 176 QINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEK 235
+I +Q K++ E ++ +LSF+ F+H+GY+L E PY + L L + +
Sbjct: 184 KIQEVQEKKKFEFVEPLLSFLQGLFTFYHEGYELAQEFAPYKQQLQFNLQNTRNNFESTR 243
Query: 236 REMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKRASNAFK-TWNRRW------ 288
+E+E+ +Q+ ++ D + + MEGYL+ + TW + +
Sbjct: 244 QEVER---LMQRMKSANQDYR------PPSQWTMEGYLYVQEKRPLGFTWIKHYCTYDKG 294
Query: 289 ---FSIQNNQLVYQKKFKDNPTVVVE--DLRLCTVKHCEDIERRFCF--EVVSPTKSCML 341
F++ +++ K T E L+ C + + I++RFCF EVV L
Sbjct: 295 SKTFTMSVSEMKSSGKMNGLVTSSPEMFKLKSCIRRKTDSIDKRFCFDIEVVERHGIITL 354
Query: 342 QADSEKLRQAWIKAV 356
QA SE R+ W++A+
Sbjct: 355 QAFSEANRKLWLEAM 369
>gi|21264558 stromal membrane-associated GTPase-activating protein 1
isoform B [Homo sapiens]
Length = 440
Score = 110 bits (275), Expect = 5e-24
Identities = 53/127 (41%), Positives = 82/127 (64%), Gaps = 3/127 (2%)
Query: 411 NASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCEL 470
N C DC PRWAS N+G+ +CI C+GIHR+LGVH S+V+S+ LD W E ++ M ++
Sbjct: 30 NKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTAEQIQCMQDM 89
Query: 471 GNDVINRVYEANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFV 530
GN +YEAN+ + ++PQ Q E +IR KY ++K+ DK +I+++ E++KK
Sbjct: 90 GNTKARLLYEANLPE-NFRRPQTD--QAVEFFIRDKYEKKKYYDKNAIAITNKEKEKKKE 146
Query: 531 SKSSEEK 537
K E++
Sbjct: 147 EKKREKE 153
>gi|24586663 adaptor protein, phosphotyrosine interaction, PH domain
and leucine zipper containing 2 [Homo sapiens]
Length = 664
Score = 109 bits (272), Expect = 1e-23
Identities = 97/385 (25%), Positives = 174/385 (45%), Gaps = 30/385 (7%)
Query: 8 EECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLA 67
EE L+DSP+ R+ L E D L ++L++ + C+A +Q + LA
Sbjct: 10 EEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSKQL--LA 67
Query: 68 QYSSN------DAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFK 121
N D V ++L FS + E+ HT L Q ++ + F ++DL +
Sbjct: 68 YEKQNFALGKGDEEVISTLHYFSKVVDELNLLHTELAKQLADTMVLPIIQFREKDLTEVS 127
Query: 122 DAKKQFEKVSEEKENALVKNAQVQRNKQHE---VEEATNILTATRKCFRHIA-LDYVLQI 177
K F S E + ++ K +++ + K++E E + A RK +H++ L Y +
Sbjct: 128 TLKDLFGLASNEHDLSMAKYSRLPKKKENEKVKTEVGKEVAAARRK--QHLSSLQYYCAL 185
Query: 178 NVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSE-LGPYMKDLGAQLDRLVVDAAKEKR 236
N LQ +++ +++ M+ F + + FF +G ++FS+ + ++ + + + V+ E
Sbjct: 186 NALQYRKQMAMMEPMIGFAHGQINFFKKGAEMFSKRMDSFLSSVADMVQSIQVELEAEAE 245
Query: 237 EMEQKHSTIQQKDFSSDDSKLEYNVDAA------NGIVMEGYLFKRASNAF--KTWNRRW 288
+M QQ+ S D+S + D A N I GYL R TW R +
Sbjct: 246 KMR----VSQQELLSVDESVYTPDSDVAAPQINRNLIQKAGYLNLRNKTGLVTTTWERLY 301
Query: 289 FSIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPT--KSCMLQADSE 346
F Q L+ Q + +++DL C+V + +RR+CF++ +P +LQA+S
Sbjct: 302 FFTQGGNLMCQPR-GAVAGGLIQDLDNCSVMAVDCEDRRYCFQITTPNGKSGIILQAESR 360
Query: 347 KLRQAWIKAVQTSIATAYREKGDES 371
K + WI A+ Y E+
Sbjct: 361 KENEEWICAINNISRQIYLTDNPEA 385
>gi|6912242 adaptor protein, phosphotyrosine interaction, PH domain
and leucine zipper containing 1 [Homo sapiens]
Length = 709
Score = 106 bits (264), Expect = 9e-23
Identities = 89/386 (23%), Positives = 176/386 (45%), Gaps = 34/386 (8%)
Query: 8 EECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLA 67
EE L+DSP+ R+ L E D + +++L + + D A +++
Sbjct: 10 EETLEDSPQTRSLLGVFEEDATAISNYMNQLYQAMHRIYDAQNELSAATHLTSKLLKEYE 69
Query: 68 QY----SSNDAVVETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFKDA 123
+ +D V+ ++L +FS + E+ + H +L Q ++ + F + DL++
Sbjct: 70 KQRFPLGGDDEVMSSTLQQFSKVIDELSSCHAVLSTQLADAMMFPITQFKERDLKEILTL 129
Query: 124 KKQFEKVSEEKENALVKNAQVQRNKQHE--VEEATNILTATRKCFRHIALDYVLQINVLQ 181
K+ F+ S + + A+ + +++ + ++++ E T + +RK + Y +N LQ
Sbjct: 130 KEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYTSRKKQHQTMMHYFCALNTLQ 189
Query: 182 SKRRSEILKSMLSFMYAHLAFFHQGYD-LFSELGPYMKDLGAQLDRLVVDAAKEKREMEQ 240
K++ +L+ +L +M A ++FF G + L +L ++ ++G + + +REM+
Sbjct: 190 YKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNV-------RREMDS 242
Query: 241 KHSTIQQ--KDF----------SSDDSKLEYNVDAANGIVMEGYLFKRASNAF--KTWNR 286
T+QQ +D D +K N N GYL R TW+R
Sbjct: 243 DIETMQQTIEDLEVASDPLYVPDPDPTKFPVN---RNLTRKAGYLNARNKTGLVSSTWDR 299
Query: 287 RWFSIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVS--PTKSCMLQAD 344
+++ Q L+ Q + D + D+ C+V + +RR+CF++ S KS +LQA+
Sbjct: 300 QFYFTQGGNLMSQAR-GDVAGGLAMDIDNCSVMAVDCEDRRYCFQITSFDGKKSSILQAE 358
Query: 345 SEKLRQAWIKAVQTSIATAYREKGDE 370
S+K + WI + Y + E
Sbjct: 359 SKKDHEEWICTINNISKQIYLSENPE 384
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
2 [Homo sapiens]
Length = 1704
Score = 102 bits (255), Expect = 1e-21
Identities = 73/231 (31%), Positives = 109/231 (47%), Gaps = 36/231 (15%)
Query: 299 QKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQAWIKAVQT 358
++ FK + + + + VK + ++ FE+++P +S A++EK +Q WI+AVQ
Sbjct: 618 EQDFKSGLGITIIPMNVANVKQVDRTVKQ-SFEIITPYRSFSFTAETEKEKQDWIEAVQQ 676
Query: 359 SIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCG 418
SIA S E EK+ ES N SC DC
Sbjct: 677 SIAETL----------------------SDYEVAEKIWFNES----------NRSCADCK 704
Query: 419 LADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDT--WEPELLKLMCELGNDVIN 476
DP WASINL + +C +C+G HRSLG SKVRSL +D W EL++L +GN N
Sbjct: 705 APDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRAN 764
Query: 477 RVYEANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQK 527
+ N++K + ++++ +I KY E KF SL+ E K
Sbjct: 765 DFWAGNLQK-DEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNK 814
>gi|113204622 stromal membrane-associated GTPase-activating protein
1 isoform A [Homo sapiens]
Length = 467
Score = 102 bits (254), Expect = 1e-21
Identities = 48/111 (43%), Positives = 73/111 (65%), Gaps = 3/111 (2%)
Query: 411 NASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCEL 470
N C DC PRWAS N+G+ +CI C+GIHR+LGVH S+V+S+ LD W E ++ M ++
Sbjct: 30 NKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTAEQIQCMQDM 89
Query: 471 GNDVINRVYEANVEKMGIKKPQPGQRQEKEAYIRAKYVERKFVDKYSISLS 521
GN +YEAN+ + ++PQ Q E +IR KY ++K+ DK +I+++
Sbjct: 90 GNTKARLLYEANLPE-NFRRPQTD--QAVEFFIRDKYEKKKYYDKNAIAIT 137
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.369
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,980,087
Number of Sequences: 37866
Number of extensions: 1234291
Number of successful extensions: 7355
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 348
Number of HSP's successfully gapped in prelim test: 177
Number of HSP's that attempted gapping in prelim test: 5199
Number of HSP's gapped (non-prelim): 1817
length of query: 778
length of database: 18,247,518
effective HSP length: 110
effective length of query: 668
effective length of database: 14,082,258
effective search space: 9406948344
effective search space used: 9406948344
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.