Search of human proteins with 104487297

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|104487297 protein tyrosine phosphatase, receptor type, sigma
isoform 2 precursor [Homo sapiens]
         (1910 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|104487297 protein tyrosine phosphatase, receptor type, sigma ...  3880   0.0  
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ...  3846   0.0  
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo...  2810   0.0  
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo...  2804   0.0  
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor...  2796   0.0  
gi|109633039 protein tyrosine phosphatase, receptor type, F isof...  2572   0.0  
gi|109633041 protein tyrosine phosphatase, receptor type, F isof...  2564   0.0  
gi|104487611 protein tyrosine phosphatase, receptor type, sigma ...  1912   0.0  
gi|104487295 protein tyrosine phosphatase, receptor type, sigma ...  1912   0.0  
gi|104487002 protein tyrosine phosphatase, receptor type, D isof...  1519   0.0  
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo...  1506   0.0  
gi|4506303 protein tyrosine phosphatase, receptor type, A isofor...   592   e-168
gi|18450371 protein tyrosine phosphatase, receptor type, A isofo...   589   e-167
gi|18450369 protein tyrosine phosphatase, receptor type, A isofo...   589   e-167
gi|5729993 protein tyrosine phosphatase, receptor type, E isofor...   552   e-156
gi|18860859 protein tyrosine phosphatase, receptor type, E isofo...   549   e-155
gi|18860902 protein tyrosine phosphatase, receptor type, K isofo...   513   e-145
gi|208431815 protein tyrosine phosphatase, receptor type, K isof...   506   e-143
gi|157419150 protein tyrosine phosphatase, receptor type, M isof...   498   e-140
gi|157419152 protein tyrosine phosphatase, receptor type, M isof...   498   e-140
gi|148539860 protein tyrosine phosphatase, receptor type, T isof...   480   e-135
gi|148539858 protein tyrosine phosphatase, receptor type, T isof...   473   e-133
gi|194097398 protein tyrosine phosphatase, receptor type, G prec...   456   e-127
gi|110735404 protein tyrosine phosphatase, receptor type, U isof...   456   e-127
gi|110735406 protein tyrosine phosphatase, receptor type, U isof...   449   e-126
gi|110735402 protein tyrosine phosphatase, receptor type, U isof...   445   e-124
gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1 p...   412   e-114
gi|18641364 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110
gi|18641347 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110
gi|18641362 protein tyrosine phosphatase, receptor type, C isofo...   397   e-110

>gi|104487297 protein tyrosine phosphatase, receptor type, sigma
            isoform 2 precursor [Homo sapiens]
          Length = 1910

 Score = 3880 bits (10061), Expect = 0.0
 Identities = 1910/1910 (100%), Positives = 1910/1910 (100%)

Query: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
            MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
            KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
            KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181  NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240
            NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS
Sbjct: 181  NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240

Query: 241  HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300
            HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA
Sbjct: 241  HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300

Query: 301  MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360
            MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD
Sbjct: 301  MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360

Query: 361  GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
            GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV
Sbjct: 361  GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420

Query: 421  QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
            QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE
Sbjct: 421  QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480

Query: 481  DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540
            DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI
Sbjct: 481  DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540

Query: 541  IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 600
            IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT
Sbjct: 541  IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 600

Query: 601  LQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNG 660
            LQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNG
Sbjct: 601  LQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNG 660

Query: 661  IPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALN 720
            IPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALN
Sbjct: 661  IPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALN 720

Query: 721  ATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPE 780
            ATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPE
Sbjct: 721  ATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPE 780

Query: 781  TAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQ 840
            TAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQ
Sbjct: 781  TAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQ 840

Query: 841  VLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLS 900
            VLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLS
Sbjct: 841  VLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLS 900

Query: 901  IPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETE 960
            IPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETE
Sbjct: 901  IPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARETE 960

Query: 961  LPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKV 1020
            LPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKV
Sbjct: 961  LPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKV 1020

Query: 1021 KMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNR 1080
            KMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNR
Sbjct: 1021 KMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTNR 1080

Query: 1081 GSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLR 1140
            GSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLR
Sbjct: 1081 GSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLR 1140

Query: 1141 KSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHP 1200
            KSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHP
Sbjct: 1141 KSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHP 1200

Query: 1201 GDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEG 1260
            GDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEG
Sbjct: 1201 GDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPFQLDNPDPQPIVDGEEG 1260

Query: 1261 LIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMR 1320
            LIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMR
Sbjct: 1261 LIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMR 1320

Query: 1321 RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKP 1380
            RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKP
Sbjct: 1321 RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKP 1380

Query: 1381 KNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRM 1440
            KNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRM
Sbjct: 1381 KNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRM 1440

Query: 1441 VWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK 1500
            VWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK
Sbjct: 1441 VWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK 1500

Query: 1501 NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGC 1560
            NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGC
Sbjct: 1501 NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGC 1560

Query: 1561 FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPA 1620
            FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPA
Sbjct: 1561 FIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPA 1620

Query: 1621 RSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE 1680
            RSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE
Sbjct: 1621 RSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYE 1680

Query: 1681 STRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM 1740
            STRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM
Sbjct: 1681 STRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVM 1740

Query: 1741 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQ 1800
            LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQ
Sbjct: 1741 LTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQ 1800

Query: 1801 FQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE 1860
            FQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE
Sbjct: 1801 FQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLE 1860

Query: 1861 RMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1910
            RMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT
Sbjct: 1861 RMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1910


>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
            isoform 1 precursor [Homo sapiens]
          Length = 1948

 Score = 3846 bits (9973), Expect = 0.0
 Identities = 1909/1948 (97%), Positives = 1909/1948 (97%), Gaps = 38/1948 (1%)

Query: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
            MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
            KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
            KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181  NGRIKQLRS---------GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR----V 227
            NGRIKQLRS         GALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR    V
Sbjct: 181  NGRIKQLRSETFESTPIRGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREV 240

Query: 228  RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 287
            RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL
Sbjct: 241  RRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLEL 300

Query: 288  TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 347
            TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV
Sbjct: 301  TDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPV 360

Query: 348  SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 407
            SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR
Sbjct: 361  SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTR 420

Query: 408  TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 467
            TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV
Sbjct: 421  TGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNV 480

Query: 468  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 527
            DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS
Sbjct: 481  DDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETS 540

Query: 528  ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 587
            ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ
Sbjct: 541  ITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 600

Query: 588  GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 647
            GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP
Sbjct: 601  GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 660

Query: 648  LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 707
            LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP
Sbjct: 661  LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 720

Query: 708  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 767
            SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA
Sbjct: 721  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 780

Query: 768  DAQ---------EMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 818
            DAQ         EMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV
Sbjct: 781  DAQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSV 840

Query: 819  QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT 878
            QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT
Sbjct: 841  QQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGAT 900

Query: 879  YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNG 938
            YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNG
Sbjct: 901  YVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNG 960

Query: 939  AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 998
            AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP
Sbjct: 961  AIVKYTVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 1020

Query: 999  FSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR 1058
            FSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR
Sbjct: 1021 FSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGR 1080

Query: 1059 TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMV 1118
            TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMV
Sbjct: 1081 TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMV 1140

Query: 1119 YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSR 1178
            YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSR
Sbjct: 1141 YLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSR 1200

Query: 1179 QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAAS 1238
            QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAAS
Sbjct: 1201 QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAAS 1260

Query: 1239 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 1298
            PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR
Sbjct: 1261 PFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPR 1320

Query: 1299 TKCLLNNADLAPHHPKDPVEMRRINFQTP----------------GMLSHPPIPIADMAE 1342
            TKCLLNNADLAPHHPKDPVEMRRINFQTP                 MLSHPPIPIADMAE
Sbjct: 1321 TKCLLNNADLAPHHPKDPVEMRRINFQTPDSGLRSPLREPGFHFESMLSHPPIPIADMAE 1380

Query: 1343 HTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG 1402
            HTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG
Sbjct: 1381 HTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG 1440

Query: 1403 IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK 1462
            IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK
Sbjct: 1441 IMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIK 1500

Query: 1463 CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV 1522
            CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV
Sbjct: 1501 CDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGV 1560

Query: 1523 PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH 1582
            PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH
Sbjct: 1561 PEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGH 1620

Query: 1583 VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM 1642
            VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM
Sbjct: 1621 VTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGM 1680

Query: 1643 ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF 1702
            ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF
Sbjct: 1681 ELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF 1740

Query: 1703 IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA 1762
            IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA
Sbjct: 1741 IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA 1800

Query: 1763 RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1822
            RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI
Sbjct: 1801 RYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFI 1860

Query: 1823 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP 1882
            GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP
Sbjct: 1861 GQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRP 1920

Query: 1883 AMVQTEDEYQFCYQAALEYLGSFDHYAT 1910
            AMVQTEDEYQFCYQAALEYLGSFDHYAT
Sbjct: 1921 AMVQTEDEYQFCYQAALEYLGSFDHYAT 1948


>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform 2
            precursor [Homo sapiens]
          Length = 1899

 Score = 2810 bits (7284), Expect = 0.0
 Identities = 1373/1895 (72%), Positives = 1593/1895 (84%), Gaps = 28/1895 (1%)

Query: 29   AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
            AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20   AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 89   AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
            +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 149  TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECV 208
            TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSGALQIE SEE+DQGKYECV
Sbjct: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGALQIEQSEESDQGKYECV 199

Query: 209  ATNSAGVRYSSPANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVKWMQG 268
            ATNSAG RYS+PANLYVRVRRV PRFSI P +HEIMPGG+VNITCVAVGSPMPYVKWM G
Sbjct: 200  ATNSAGTRYSAPANLYVRVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLG 259

Query: 269  AEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSLPKAPGTPMVT 328
            AEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+LPK PGTP+VT
Sbjct: 260  AEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVT 319

Query: 329  ENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIW 388
            E+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS+ GLSP S+YE  
Sbjct: 320  ESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAGLSPYSDYEFR 379

Query: 389  VSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYR 448
            V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP EPNG I+GYR
Sbjct: 380  VVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYR 439

Query: 449  VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQ 508
            VYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+GDGPLS  IQV TQ
Sbjct: 440  VYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQ 499

Query: 509  QGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTTSYVV 568
             GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E   T +P TSY +
Sbjct: 500  TGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRITIEPGTSYRL 559

Query: 569  EDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRP 628
            + LKPN+ Y FRLAARSPQGLGA T  +  RT+QSKPSAPPQD+ C S  ST+ILVSW+P
Sbjct: 560  QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQP 619

Query: 629  PPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTE 688
            PP E  NG +  YS++Y  +  ED +P E+ GIP  TT+ LLE LEKWT+YRIT  AHT+
Sbjct: 620  PPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTD 679

Query: 689  VGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYV 748
            VGPGPES  V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +QHGQIRGYQVHYV
Sbjct: 680  VGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYV 739

Query: 749  RMEGAEARGPPRIKDVMLADAQ---------EMVITNLQPETAYSITVAAYTMKGDGARS 799
            RME  E +G P +KDVMLADAQ         +M+I+ LQPET+YS+TV AYT KGDGARS
Sbjct: 740  RMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARS 799

Query: 800  KPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTPLATL 859
            KPK+V T GAV G+P L +  T   + L +W PP  T    + GYRL+FGR+D  PL TL
Sbjct: 800  KPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRLKFGRKDMEPLTTL 858

Query: 860  EFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNA 919
            EF   ED +TA+ +HKGA+YVFRL+AR++ G GEE  + +SIPE+ P G PQ L + G  
Sbjct: 859  EFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHSEGTT 918

Query: 920  SAGTVLLRWLPPVPAERNGAIVKYTVAVREAGA-LGPARETELPAAAEPGAENALTLQGL 978
            S  +V L W PPV AERNG I KYT+  R+    L P  +  +PA      +  +TL GL
Sbjct: 919  ST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPA------DTTMTLTGL 971

Query: 979  KPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNY 1038
            KPDT YD++VRAHT +GPGP+SP V++RT   DQV  KNF VK +MKTSVLLSWE P+NY
Sbjct: 972  KPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENY 1031

Query: 1039 NSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTA 1096
            NS  P+KI Y+   +  +VDGR T+KLI +LKP   Y+FVLTNRG+S GGLQ  VTA TA
Sbjct: 1032 NSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTA 1091

Query: 1097 FNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPED 1156
             ++L  KP+   K + DG I V LP+  +   ++ Y+I++VPL+KSRG +F+ P  SP++
Sbjct: 1092 PDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDE 1150

Query: 1157 MDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEP 1216
            M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP  F  GD K YGGF N+ L+ 
Sbjct: 1151 MELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQS 1208

Query: 1217 GHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFII 1275
            G  YV FVLAV++ +E   +A SP+SDP    + DPQPI D EEGLIWV+GPVLAVVFII
Sbjct: 1209 GQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFII 1268

Query: 1276 CIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPI 1335
            CIVIAILLYK K    R +S+ R   + NN ++  HHP DPVE+RR+NFQTPGM SHPPI
Sbjct: 1269 CIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPI 1324

Query: 1336 PIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 1395
            PI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV
Sbjct: 1325 PILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV 1384

Query: 1396 ILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRL 1455
            +L  IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+L
Sbjct: 1385 LLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKL 1444

Query: 1456 EEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFT 1515
            EE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFT
Sbjct: 1445 EERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFT 1504

Query: 1516 AWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEK 1575
            AWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EK
Sbjct: 1505 AWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEK 1564

Query: 1576 TVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEP 1635
            TVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E 
Sbjct: 1565 TVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIET 1624

Query: 1636 GEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1695
            GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS
Sbjct: 1625 GENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGS 1684

Query: 1696 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQY 1755
            DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQY
Sbjct: 1685 DYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQY 1744

Query: 1756 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1815
            WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG
Sbjct: 1745 WPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSG 1804

Query: 1816 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1875
            EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK
Sbjct: 1805 EGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVK 1864

Query: 1876 MLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1910
            MLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1865 MLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1899


>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform 3
            precursor [Homo sapiens]
          Length = 1903

 Score = 2804 bits (7269), Expect = 0.0
 Identities = 1373/1899 (72%), Positives = 1593/1899 (83%), Gaps = 32/1899 (1%)

Query: 29   AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
            AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20   AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 89   AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
            +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 149  TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
            TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS         GALQIE SEE
Sbjct: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199

Query: 200  TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255
            +DQGKYECVATNSAG RYS+PANLYVR    VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200  SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259

Query: 256  VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315
            VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260  VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319

Query: 316  KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375
            K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 320  KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379

Query: 376  IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
            + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380  VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439

Query: 436  EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
            EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 440  EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499

Query: 496  DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
            DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 500  DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559

Query: 556  VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 615
               T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QSKPSAPPQD+ C 
Sbjct: 560  QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619

Query: 616  SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 675
            S  ST+ILVSW+PPP E  NG +  YS++Y  +  ED +P E+ GIP  TT+ LLE LEK
Sbjct: 620  SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679

Query: 676  WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 735
            WT+YRIT  AHT+VGPGPES  V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +
Sbjct: 680  WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739

Query: 736  QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGD 795
            QHGQIRGYQVHYVRME  E +G P +KDVMLADAQ+M+I+ LQPET+YS+TV AYT KGD
Sbjct: 740  QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGD 799

Query: 796  GARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQFGREDSTP 855
            GARSKPK+V T GAV G+P L +  T   + L +W PP  T    + GYRL+FGR+D  P
Sbjct: 800  GARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRLKFGRKDMEP 858

Query: 856  LATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEA 915
            L TLEF   ED +TA+ +HKGA+YVFRL+AR++ G GEE  + +SIPE+ P G PQ L +
Sbjct: 859  LTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQNLHS 918

Query: 916  AGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGA-LGPARETELPAAAEPGAENALT 974
             G  S  +V L W PPV AERNG I KYT+  R+    L P  +  +PA      +  +T
Sbjct: 919  EGTTST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPA------DTTMT 971

Query: 975  LQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMKTSVLLSWEF 1034
            L GLKPDT YD++VRAHT +GPGP+SP V++RT   DQV  KNF VK +MKTSVLLSWE 
Sbjct: 972  LTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEI 1031

Query: 1035 PDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVT 1092
            P+NYNS  P+KI Y+   +  +VDGR T+KLI +LKP   Y+FVLTNRG+S GGLQ  VT
Sbjct: 1032 PENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVT 1091

Query: 1093 AWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSRGGQFLTPLG 1152
            A TA ++L  KP+   K + DG I V LP+  +   ++ Y+I++VPL+KSRG +F+ P  
Sbjct: 1092 AKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSRG-KFIKPWE 1150

Query: 1153 SPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNR 1212
            SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP  F  GD K YGGF N+
Sbjct: 1151 SPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDDKHYGGFTNK 1208

Query: 1213 GLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAV 1271
             L+ G  YV FVLAV++ +E   +A SP+SDP    + DPQPI D EEGLIWV+GPVLAV
Sbjct: 1209 QLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAV 1268

Query: 1272 VFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLS 1331
            VFIICIVIAILLYK K    R +S+ R   + NN ++  HHP DPVE+RR+NFQTPGM S
Sbjct: 1269 VFIICIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRRLNFQTPGMAS 1324

Query: 1332 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1391
            HPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD
Sbjct: 1325 HPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1384

Query: 1392 HSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM 1451
            HSRV+L  IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+WEQRSAT+VM
Sbjct: 1385 HSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVM 1444

Query: 1452 MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1511
            MT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNGSSEKREVRQ
Sbjct: 1445 MTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQ 1504

Query: 1512 FQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI 1571
            FQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFIVIDAMLERI
Sbjct: 1505 FQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERI 1564

Query: 1572 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA 1631
            K EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+LYAYIQKL 
Sbjct: 1565 KHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLT 1624

Query: 1632 QVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRG 1691
            Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRG
Sbjct: 1625 QIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRG 1684

Query: 1692 VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREK 1751
            VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLTKLREMGREK
Sbjct: 1685 VEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREK 1744

Query: 1752 CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV 1811
            CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV
Sbjct: 1745 CHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGV 1804

Query: 1812 PKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1871
            PKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF
Sbjct: 1805 PKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1864

Query: 1872 QTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1910
            QTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1865 QTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1903


>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
            precursor [Homo sapiens]
          Length = 1912

 Score = 2796 bits (7249), Expect = 0.0
 Identities = 1373/1908 (71%), Positives = 1593/1908 (83%), Gaps = 41/1908 (2%)

Query: 29   AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
            AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20   AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 89   AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
            +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80   SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 149  TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
            TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS         GALQIE SEE
Sbjct: 140  TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199

Query: 200  TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255
            +DQGKYECVATNSAG RYS+PANLYVR    VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200  SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259

Query: 256  VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315
            VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260  VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319

Query: 316  KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375
            K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 320  KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379

Query: 376  IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
            + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380  VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439

Query: 436  EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
            EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 440  EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499

Query: 496  DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
            DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 500  DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559

Query: 556  VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 615
               T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QSKPSAPPQD+ C 
Sbjct: 560  QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619

Query: 616  SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 675
            S  ST+ILVSW+PPP E  NG +  YS++Y  +  ED +P E+ GIP  TT+ LLE LEK
Sbjct: 620  SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679

Query: 676  WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 735
            WT+YRIT  AHT+VGPGPES  V++RT+EDVPS PPRKVE EA+N+T+++V WRSP P +
Sbjct: 680  WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739

Query: 736  QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ---------EMVITNLQPETAYSIT 786
            QHGQIRGYQVHYVRME  E +G P +KDVMLADAQ         +M+I+ LQPET+YS+T
Sbjct: 740  QHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLT 799

Query: 787  VAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRL 846
            V AYT KGDGARSKPK+V T GAV G+P L +  T   + L +W PP  T    + GYRL
Sbjct: 800  VTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTF-GPLQGYRL 858

Query: 847  QFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTP 906
            +FGR+D  PL TLEF   ED +TA+ +HKGA+YVFRL+AR++ G GEE  + +SIPE+ P
Sbjct: 859  KFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISIPEEVP 918

Query: 907  RGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGA-LGPARETELPAAA 965
             G PQ L + G  S  +V L W PPV AERNG I KYT+  R+    L P  +  +PA  
Sbjct: 919  TGFPQNLHSEGTTST-SVQLSWQPPVLAERNGIITKYTLLYRDINIPLLPMEQLIVPA-- 975

Query: 966  EPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKMIMK 1025
                +  +TL GLKPDT YD++VRAHT +GPGP+SP V++RT   DQV  KNF VK +MK
Sbjct: 976  ----DTTMTLTGLKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMK 1031

Query: 1026 TSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTKKLITHLKPHTFYNFVLTNRGSS 1083
            TSVLLSWE P+NYNS  P+KI Y+   +  +VDGR T+KLI +LKP   Y+FVLTNRG+S
Sbjct: 1032 TSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNS 1091

Query: 1084 LGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPLRKSR 1143
             GGLQ  VTA TA ++L  KP+   K + DG I V LP+  +   ++ Y+I++VPL+KSR
Sbjct: 1092 AGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPANENIKGYYIIIVPLKKSR 1151

Query: 1144 GGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTFHPGDQ 1203
            G +F+ P  SP++M+L+EL+++ISR +RRS+R+ R++E+ +PYIAA F VLP  F  GD 
Sbjct: 1152 G-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVEL-KPYIAAHFDVLPTEFTLGDD 1208

Query: 1204 KQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPFSDPFQLDNPDPQPIVDGEEGLI 1262
            K YGGF N+ L+ G  YV FVLAV++ +E   +A SP+SDP    + DPQPI D EEGLI
Sbjct: 1209 KHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLI 1268

Query: 1263 WVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLAPHHPKDPVEMRRI 1322
            WV+GPVLAVVFIICIVIAILLYK K    R +S+ R   + NN ++  HHP DPVE+RR+
Sbjct: 1269 WVVGPVLAVVFIICIVIAILLYKRK----RAESDSRKSSIPNNKEIPSHHPTDPVELRRL 1324

Query: 1323 NFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKN 1382
            NFQTPGM SHPPIPI ++A+H ERLKAND+LK SQEYESIDPGQQFTWEHSNLEVNKPKN
Sbjct: 1325 NFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKN 1384

Query: 1383 RYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVW 1442
            RYANVIAYDHSRV+L  IEGI GSDY+NANY+DGYR QNAYIATQG LPETFGDFWRM+W
Sbjct: 1385 RYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIW 1444

Query: 1443 EQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNG 1502
            EQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QVTLLDT+ELAT+CVRTF+L+KNG
Sbjct: 1445 EQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNG 1504

Query: 1503 SSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFI 1562
            SSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCNPPDAGP+VVHCSAGVGRTGCFI
Sbjct: 1505 SSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFI 1564

Query: 1563 VIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARS 1622
            VIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY FIH+ALLEAV CGNTEVPAR+
Sbjct: 1565 VIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARN 1624

Query: 1623 LYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYEST 1682
            LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFISANLPCNKFKNRLVNIMPYEST
Sbjct: 1625 LYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYEST 1684

Query: 1683 RVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLT 1742
            RVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE+NSTIVVMLT
Sbjct: 1685 RVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLT 1744

Query: 1743 KLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1802
            KLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ
Sbjct: 1745 KLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQ 1804

Query: 1803 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1862
            FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM
Sbjct: 1805 FTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERM 1864

Query: 1863 RYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1910
            RYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALEYLGSFDHYAT
Sbjct: 1865 RYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALEYLGSFDHYAT 1912


>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform 2
            precursor [Homo sapiens]
          Length = 1898

 Score = 2572 bits (6666), Expect = 0.0
 Identities = 1301/1918 (67%), Positives = 1500/1918 (78%), Gaps = 28/1918 (1%)

Query: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
            MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60

Query: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
            KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120

Query: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
            KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180

Query: 181  NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240
            NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVRVRRVAPRFSI P S
Sbjct: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240

Query: 241  HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300
             E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V  SANYTCVA
Sbjct: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300

Query: 301  MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360
            +SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV+YY I+Y++   +
Sbjct: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360

Query: 361  GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
            GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  RTGEQAP+S PR V
Sbjct: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420

Query: 421  QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
            QARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN D  LLTTVGSLL 
Sbjct: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480

Query: 481  DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540
              TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T I LSW  P QE I
Sbjct: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540

Query: 541  IKYELLFREG-DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQR 599
            I YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS  G+G FTP +  R
Sbjct: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600

Query: 600  TLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVN 659
            T QS PSAPPQ V CVS+ ST + VSW PPP ++ NG +  YSV Y  +  ED     V+
Sbjct: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660

Query: 660  GIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEAL 719
            GI    +   L  LEKWT+YR+   AHT+VGPGPESSPV+VRTDEDVPS PPRKVE E L
Sbjct: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720

Query: 720  NATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQP 779
            N+TA+ V W+ P P +QHGQIRGYQV YVR+E  E RG P I+DVMLA+AQE  I+ L P
Sbjct: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTP 780

Query: 780  ETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAED 839
            ET YS+TVAAYT KGDGARSKPK+V T GAV GRPT+ +  T   + L +W PP      
Sbjct: 781  ETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPK-ELPG 839

Query: 840  QVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVL 899
            ++LGYRLQ+ R D     T++F   +  +T +G+HKG TY+FRLAA++R GLGEE  + +
Sbjct: 840  ELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 899

Query: 900  SIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARET 959
              PED P G PQ L   G  +  T  L W PPV AERNG I+ YTV  R+  +     + 
Sbjct: 900  RTPEDLPSGFPQNLHVTG-LTTSTTELAWDPPVLAERNGRIISYTVVFRDINS-----QQ 953

Query: 960  ELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFK 1019
            EL        +   TL GLKPDT YD++VRA T +G GP SP ++ RT   +QV  KNF+
Sbjct: 954  ELQNIT---TDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFR 1010

Query: 1020 VKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHTFYNFVLTN 1079
            V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG + +KLI  L+P+T Y+FVL N
Sbjct: 1011 VAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMN 1070

Query: 1080 RGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQSYFIVMVPL 1139
            RGSS GGLQ  V+  TA +LL  KP  A     DG   + +P  Q P  V+ ++IV+VP+
Sbjct: 1071 RGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPI 1130

Query: 1140 RKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPTF 1198
             +  GG  LTP  S PE+++L+EL++ I +      R  RQ E  +PY+AA+  VLP TF
Sbjct: 1131 DRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETF 1189

Query: 1199 HPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQLDNPDPQPIVD 1256
              GD+K Y GF NR L P   Y  FVLA L++   +  +A+SP+SD   +     Q   +
Sbjct: 1190 TLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEE 1249

Query: 1257 GEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKCLLNNADLAPHH 1312
             E  ++WV GPVLAV+ II IVIAILL+K K    P SK + S      LL        H
Sbjct: 1250 PE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLA-------H 1300

Query: 1313 PKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEH 1372
              DPVEMRR+N+QTPGM  HPPIPI D+A++ ERLKAND LK SQEYESIDPGQQFTWE+
Sbjct: 1301 SSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWEN 1360

Query: 1373 SNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPE 1432
            SNLEVNKPKNRYANVIAYDHSRVIL  I+G+ GSDYINANY+DGYR QNAYIATQGPLPE
Sbjct: 1361 SNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPE 1420

Query: 1433 TFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFC 1492
            T GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVTLLDT+ELAT+ 
Sbjct: 1421 TMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYT 1480

Query: 1493 VRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCS 1552
            VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP DAGP+VVHCS
Sbjct: 1481 VRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCS 1540

Query: 1553 AGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVG 1612
            AGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY FIHEALLEA  
Sbjct: 1541 AGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAT 1600

Query: 1613 CGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNR 1672
            CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFISANLPCNKFKNR
Sbjct: 1601 CGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNR 1660

Query: 1673 LVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWE 1732
            LVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+TEDFWRMLWE
Sbjct: 1661 LVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWE 1720

Query: 1733 NNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD 1792
            +NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD
Sbjct: 1721 HNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARD 1780

Query: 1793 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1852
            GQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCSAGVGRTGVF
Sbjct: 1781 GQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVF 1840

Query: 1853 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYAT 1910
            ITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEYLGSFDHYAT
Sbjct: 1841 ITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT 1898


>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform 1
            precursor [Homo sapiens]
          Length = 1907

 Score = 2564 bits (6646), Expect = 0.0
 Identities = 1301/1927 (67%), Positives = 1500/1927 (77%), Gaps = 37/1927 (1%)

Query: 1    MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
            MAP   PG   V     L+++ LV G   +  P FIK P+DQ G+SGGVASFVCQATG+P
Sbjct: 1    MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEP 60

Query: 61   KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
            KPR+TW KKGKKV+SQRFE IEFD+ AG+VLRIQPLR  RDE +YEC A NS+GEI   A
Sbjct: 61   KPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSA 120

Query: 121  KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
            KL+VL E+QLP GFP+IDMGPQLKVVE+ RTATMLCAA GNPDPEI+WFKDFLPVDP+ S
Sbjct: 121  KLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATS 180

Query: 181  NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240
            NGRIKQLRSGALQIESSEE+DQGKYECVATNSAG RYS+PANLYVRVRRVAPRFSI P S
Sbjct: 181  NGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSS 240

Query: 241  HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300
             E+MPGG+VN+TCVAVG+PMPYVKWM GAE+LT ED+MPVGRNVLEL++V  SANYTCVA
Sbjct: 241  QEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVA 300

Query: 301  MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360
            +SSLG+IEA AQ+TVK+LPK P   +VTE TATS+T+TWDSGN +PV+YY I+Y++   +
Sbjct: 301  ISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTE 360

Query: 361  GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
            GP+Q  + + TTRYSIGGLSP SEY   V AVNSIG+GPPSE+V  RTGEQAP+S PR V
Sbjct: 361  GPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRV 420

Query: 421  QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
            QARMLSA+TM+VQWE P EPNGL+RGYRVYYT +   P   W KHN D  LLTTVGSLL 
Sbjct: 421  QARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLP 480

Query: 481  DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540
              TY++RVLAFT+VGDGP S  IQVKTQQGVP QP + +AE  S+T I LSW  P QE I
Sbjct: 481  GITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERI 540

Query: 541  IKYELLFREG-DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQR 599
            I YEL++    D  ++   TFDPT+SY +EDLKP+T Y F+LAARS  G+G FTP +  R
Sbjct: 541  IMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEAR 600

Query: 600  TLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVN 659
            T QS PSAPPQ V CVS+ ST + VSW PPP ++ NG +  YSV Y  +  ED     V+
Sbjct: 601  TAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVD 660

Query: 660  GIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEAL 719
            GI    +   L  LEKWT+YR+   AHT+VGPGPESSPV+VRTDEDVPS PPRKVE E L
Sbjct: 661  GISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPL 720

Query: 720  NATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ--------- 770
            N+TA+ V W+ P P +QHGQIRGYQV YVR+E  E RG P I+DVMLA+AQ         
Sbjct: 721  NSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDY 780

Query: 771  EMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARW 830
            E  I+ L PET YS+TVAAYT KGDGARSKPK+V T GAV GRPT+ +  T   + L +W
Sbjct: 781  ETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQW 840

Query: 831  EPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGG 890
             PP      ++LGYRLQ+ R D     T++F   +  +T +G+HKG TY+FRLAA++R G
Sbjct: 841  HPPK-ELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAG 899

Query: 891  LGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREA 950
            LGEE  + +  PED P G PQ L   G  +  T  L W PPV AERNG I+ YTV  R+ 
Sbjct: 900  LGEEFEKEIRTPEDLPSGFPQNLHVTG-LTTSTTELAWDPPVLAERNGRIISYTVVFRDI 958

Query: 951  GALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLR 1010
             +     + EL        +   TL GLKPDT YD++VRA T +G GP SP ++ RT   
Sbjct: 959  NS-----QQELQNIT---TDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPV 1010

Query: 1011 DQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLKPH 1070
            +QV  KNF+V   MKTSVLLSWE PD+Y S  P+KI YNG +++VDG + +KLI  L+P+
Sbjct: 1011 EQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPN 1070

Query: 1071 TFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQSPVPVQ 1130
            T Y+FVL NRGSS GGLQ  V+  TA +LL  KP  A     DG   + +P  Q P  V+
Sbjct: 1071 TEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVR 1130

Query: 1131 SYFIVMVPLRKSRGGQFLTPLGS-PEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAA 1189
             ++IV+VP+ +  GG  LTP  S PE+++L+EL++ I +      R  RQ E  +PY+AA
Sbjct: 1131 WFYIVVVPIDRV-GGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAA 1189

Query: 1190 RFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQK--SEPTFAASPFSDPFQLD 1247
            +  VLP TF  GD+K Y GF NR L P   Y  FVLA L++   +  +A+SP+SD   + 
Sbjct: 1190 QLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQ 1249

Query: 1248 NPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNK----PDSKRKDSEPRTKCLL 1303
                Q   + E  ++WV GPVLAV+ II IVIAILL+K K    P SK + S      LL
Sbjct: 1250 VTPAQQQEEPE--MLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLL 1307

Query: 1304 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 1363
                    H  DPVEMRR+N+QTPGM  HPPIPI D+A++ ERLKAND LK SQEYESID
Sbjct: 1308 A-------HSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESID 1360

Query: 1364 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1423
            PGQQFTWE+SNLEVNKPKNRYANVIAYDHSRVIL  I+G+ GSDYINANY+DGYR QNAY
Sbjct: 1361 PGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAY 1420

Query: 1424 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1483
            IATQGPLPET GDFWRMVWEQR+AT+VMMTRLEEKSR+KCDQYWP RGTET G IQVTLL
Sbjct: 1421 IATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLL 1480

Query: 1484 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1543
            DT+ELAT+ VRTF+LHK+GSSEKRE+RQFQF AWPDHGVPEYPTP LAFLRRVK CNP D
Sbjct: 1481 DTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLD 1540

Query: 1544 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1603
            AGP+VVHCSAGVGRTGCFIVIDAMLER+K EKTVD+YGHVT MRSQRNYMVQTEDQY FI
Sbjct: 1541 AGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFI 1600

Query: 1604 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISAN 1663
            HEALLEA  CG+TEVPAR+LYA+IQKL QV PGE VT MELEFK LA+SKAHTSRFISAN
Sbjct: 1601 HEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISAN 1660

Query: 1664 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1723
            LPCNKFKNRLVNIMPYE TRVCLQPIRGVEGSDYINASF+DGYRQQKAYIATQGPLAE+T
Sbjct: 1661 LPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAEST 1720

Query: 1724 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1783
            EDFWRMLWE+NSTI+VMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR
Sbjct: 1721 EDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1780

Query: 1784 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCS 1843
            EFKVTDARDGQSRT+RQFQFTDWPEQGVPK+GEGFIDFIGQVHKTKEQFGQDGPI+VHCS
Sbjct: 1781 EFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCS 1840

Query: 1844 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1903
            AGVGRTGVFITLSIVLERMRYEGVVD+FQTVK LRTQRPAMVQTED+YQ CY+AALEYLG
Sbjct: 1841 AGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLG 1900

Query: 1904 SFDHYAT 1910
            SFDHYAT
Sbjct: 1901 SFDHYAT 1907


>gi|104487611 protein tyrosine phosphatase, receptor type, sigma
            isoform 4 precursor [Homo sapiens]
          Length = 1505

 Score = 1912 bits (4952), Expect = 0.0
 Identities = 985/1266 (77%), Positives = 1047/1266 (82%), Gaps = 36/1266 (2%)

Query: 649  GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS 708
            G+ED  P++   +P     + L  ++    Y  T VA + +G     + + V++   +P 
Sbjct: 272  GAEDLTPED--DMPVGRNVLELTDVKDSANY--TCVAMSSLGVIEAVAQITVKS---LPK 324

Query: 709  APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLAD 768
            AP   +  E   AT+I + W S  P      +  Y + Y   +     GP +IK+ +   
Sbjct: 325  APGTPMVTEN-TATSITITWDSGNPD----PVSYYVIEY---KSKSQDGPYQIKEDITTT 376

Query: 769  AQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQ--QTPEGSL 826
                 I  L P + Y I V+A    G G  S+  V  T          +VQ       ++
Sbjct: 377  RYS--IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTM 434

Query: 827  LARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRY--TASGVHKGATYVFRLA 884
            + +WE P       + GYR+ +  E   P+   +    +D    T   + +  TY  R+ 
Sbjct: 435  IVQWEEPV-EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVL 493

Query: 885  ARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYT 944
            A +  G G  +  +    +    G P  L A   +   ++ L W PP    R  +I+KY 
Sbjct: 494  AFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPP----RQESIIKYE 548

Query: 945  VAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVR 1004
            +  RE          E+    +P    +  ++ LKP+T Y  ++ A + +G G F+P VR
Sbjct: 549  LLFREGD-----HGREVGRTFDP--TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVR 601

Query: 1005 YRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI 1064
             RT     +SPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI
Sbjct: 602  QRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI 659

Query: 1065 THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ 1124
            THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ
Sbjct: 660  THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ 719

Query: 1125 SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR 1184
            SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR
Sbjct: 720  SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR 779

Query: 1185 PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF 1244
            PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF
Sbjct: 780  PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF 839

Query: 1245 QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN 1304
            QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN
Sbjct: 840  QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN 899

Query: 1305 NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP 1364
            NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP
Sbjct: 900  NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP 959

Query: 1365 GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI 1424
            GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI
Sbjct: 960  GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI 1019

Query: 1425 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1484
            ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD
Sbjct: 1020 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1079

Query: 1485 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1544
            TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA
Sbjct: 1080 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1139

Query: 1545 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1604
            GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH
Sbjct: 1140 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1199

Query: 1605 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL 1664
            EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL
Sbjct: 1200 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL 1259

Query: 1665 PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE 1724
            PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE
Sbjct: 1260 PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE 1319

Query: 1725 DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE 1784
            DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE
Sbjct: 1320 DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE 1379

Query: 1785 FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1844
            FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA
Sbjct: 1380 FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1439

Query: 1845 GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1904
            GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS
Sbjct: 1440 GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1499

Query: 1905 FDHYAT 1910
            FDHYAT
Sbjct: 1500 FDHYAT 1505



 Score = 1221 bits (3160), Expect = 0.0
 Identities = 614/652 (94%), Positives = 624/652 (95%), Gaps = 10/652 (1%)

Query: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
           MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
           KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
           KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSI 236
           NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVR    VRRVAPRFSI
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRELREVRRVAPRFSI 240

Query: 237 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 296
           LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY
Sbjct: 241 LPMSHEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANY 300

Query: 297 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 356
           TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS
Sbjct: 301 TCVAMSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKS 360

Query: 357 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 416
           KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA
Sbjct: 361 KSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASA 420

Query: 417 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 476
           PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG
Sbjct: 421 PRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVG 480

Query: 477 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 536
           SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR
Sbjct: 481 SLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPR 540

Query: 537 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 596
           QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV
Sbjct: 541 QESIIKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVV 600

Query: 597 RQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPL 648
           RQRTLQ   S  P++ K   +  T++L+SW    P+ +N     Y ++Y  L
Sbjct: 601 RQRTLQ---SISPKNFKVKMIMKTSVLLSWE--FPDNYNSP-TPYKIQYNGL 646



 Score =  116 bits (291), Expect = 2e-25
 Identities = 159/721 (22%), Positives = 290/721 (40%), Gaps = 103/721 (14%)

Query: 152 ATMLCAASGNPDPEITWFKD--------FLPVDPSASNG---RIKQLRSGALQIESSEET 200
           A+ +C A+G+P P +TW K         F  ++   S G   RI+ LR+           
Sbjct: 50  ASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRT---------PR 100

Query: 201 DQGKYECVATNSAGVRYSSPANLYV----RVRRVAPRFSILPMSHEIMPGGNVNITCVAV 256
           D+  YECVA NS G   +  A L V    ++    P   + P    +       + C A 
Sbjct: 101 DENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS 159

Query: 257 GSPMPYVKWMQGAEDLTPE------DDMPVGRNVLELTDVKDSANYTCVAMSSLGV-IEA 309
           G+P P + W +    + P         +  G   +E ++  D   Y CVA +S GV   +
Sbjct: 160 GNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSS 219

Query: 310 VAQITVKSL-------PKAPGTPMVTE-NTATSITITWDS-GNPDPVSYYVIEYKSKSQD 360
            A + V+ L       P+    PM  E     ++ IT  + G+P P     +++   ++D
Sbjct: 220 PANLYVRELREVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY----VKWMQGAED 275

Query: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
                ++D+   R  +              A++S+G     E+V   T +  P  AP   
Sbjct: 276 --LTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGV---IEAVAQITVKSLP-KAPGTP 329

Query: 421 QARMLSATTMIVQWE----EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT-- 474
                +AT++ + W+    +PV           YY +E +    +   + + + + TT  
Sbjct: 330 MVTENTATSITITWDSGNPDPVS----------YYVIEYKSKSQDGP-YQIKEDITTTRY 378

Query: 475 -VGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSW 532
            +G L  +  Y + V A  S+G GP S+ +  +T +  P   P N++A   S T++ + W
Sbjct: 379 SIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQW 438

Query: 533 SPPRQES--IIKYELLFR-EGDH--GREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQ 587
             P + +  I  Y + +  E +H  G       D +    V  L  +  Y  R+ A +  
Sbjct: 439 EEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSV 498

Query: 588 GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRP 647
           G G  +  ++ +T Q  P  P  +++  +   T+I +SW PP  E+         ++Y  
Sbjct: 499 GDGPLSDPIQVKTQQGVPGQP-MNLRAEARSETSITLSWSPPRQES--------IIKYEL 549

Query: 648 LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 707
           L  E    +EV      TT  ++E L+  T+Y     A +  G G  +  V  RT   + 
Sbjct: 550 LFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT---LQ 606

Query: 708 SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRME-GAEARGPPRIKDVML 766
           S  P+  + + +  T++ + W  P     +     Y++ Y  +    + R          
Sbjct: 607 SISPKNFKVKMIMKTSVLLSWEFP---DNYNSPTPYKIQYNGLTLDVDGR---------- 653

Query: 767 ADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSL 826
               + +IT+L+P T Y+  +        G +           + G+P+++ +   +G +
Sbjct: 654 --TTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFI 711

Query: 827 L 827
           +
Sbjct: 712 M 712


>gi|104487295 protein tyrosine phosphatase, receptor type, sigma
            isoform 3 precursor [Homo sapiens]
          Length = 1501

 Score = 1912 bits (4952), Expect = 0.0
 Identities = 985/1266 (77%), Positives = 1047/1266 (82%), Gaps = 36/1266 (2%)

Query: 649  GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS 708
            G+ED  P++   +P     + L  ++    Y  T VA + +G     + + V++   +P 
Sbjct: 268  GAEDLTPED--DMPVGRNVLELTDVKDSANY--TCVAMSSLGVIEAVAQITVKS---LPK 320

Query: 709  APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLAD 768
            AP   +  E   AT+I + W S  P      +  Y + Y   +     GP +IK+ +   
Sbjct: 321  APGTPMVTEN-TATSITITWDSGNPD----PVSYYVIEY---KSKSQDGPYQIKEDITTT 372

Query: 769  AQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQ--QTPEGSL 826
                 I  L P + Y I V+A    G G  S+  V  T          +VQ       ++
Sbjct: 373  RYS--IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTM 430

Query: 827  LARWEPPAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRY--TASGVHKGATYVFRLA 884
            + +WE P       + GYR+ +  E   P+   +    +D    T   + +  TY  R+ 
Sbjct: 431  IVQWEEPV-EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVL 489

Query: 885  ARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYT 944
            A +  G G  +  +    +    G P  L A   +   ++ L W PP    R  +I+KY 
Sbjct: 490  AFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSET-SITLSWSPP----RQESIIKYE 544

Query: 945  VAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVR 1004
            +  RE          E+    +P    +  ++ LKP+T Y  ++ A + +G G F+P VR
Sbjct: 545  LLFREGD-----HGREVGRTFDP--TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVR 597

Query: 1005 YRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI 1064
             RT     +SPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI
Sbjct: 598  QRTL--QSISPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLI 655

Query: 1065 THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ 1124
            THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ
Sbjct: 656  THLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLPDGQ 715

Query: 1125 SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR 1184
            SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR
Sbjct: 716  SPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPR 775

Query: 1185 PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF 1244
            PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF
Sbjct: 776  PYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFAASPFSDPF 835

Query: 1245 QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN 1304
            QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN
Sbjct: 836  QLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLN 895

Query: 1305 NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP 1364
            NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP
Sbjct: 896  NADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDP 955

Query: 1365 GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI 1424
            GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI
Sbjct: 956  GQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYI 1015

Query: 1425 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1484
            ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD
Sbjct: 1016 ATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLD 1075

Query: 1485 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1544
            TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA
Sbjct: 1076 TIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDA 1135

Query: 1545 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1604
            GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH
Sbjct: 1136 GPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIH 1195

Query: 1605 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL 1664
            EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL
Sbjct: 1196 EALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANL 1255

Query: 1665 PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE 1724
            PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE
Sbjct: 1256 PCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTE 1315

Query: 1725 DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE 1784
            DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE
Sbjct: 1316 DFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILRE 1375

Query: 1785 FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1844
            FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA
Sbjct: 1376 FKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSA 1435

Query: 1845 GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1904
            GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS
Sbjct: 1436 GVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1495

Query: 1905 FDHYAT 1910
            FDHYAT
Sbjct: 1496 FDHYAT 1501



 Score = 1227 bits (3175), Expect = 0.0
 Identities = 614/648 (94%), Positives = 624/648 (96%), Gaps = 6/648 (0%)

Query: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60
           MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP
Sbjct: 1   MAPTWGPGMVSVVGPMGLLVVLLVGGCAAEEPPRFIKEPKDQIGVSGGVASFVCQATGDP 60

Query: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120
           KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA
Sbjct: 61  KPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRTPRDENVYECVAQNSVGEITVHA 120

Query: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180
           KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS
Sbjct: 121 KLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDPSAS 180

Query: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240
           NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS
Sbjct: 181 NGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSSPANLYVRVRRVAPRFSILPMS 240

Query: 241 HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300
           HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA
Sbjct: 241 HEIMPGGNVNITCVAVGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVA 300

Query: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360
           MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD
Sbjct: 301 MSSLGVIEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQD 360

Query: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420
           GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV
Sbjct: 361 GPYQIKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNV 420

Query: 421 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480
           QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE
Sbjct: 421 QARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLE 480

Query: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540
           DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI
Sbjct: 481 DETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESI 540

Query: 541 IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 600
           IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT
Sbjct: 541 IKYELLFREGDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT 600

Query: 601 LQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPL 648
           LQ   S  P++ K   +  T++L+SW    P+ +N     Y ++Y  L
Sbjct: 601 LQ---SISPKNFKVKMIMKTSVLLSWE--FPDNYNSP-TPYKIQYNGL 642



 Score =  116 bits (290), Expect = 2e-25
 Identities = 159/717 (22%), Positives = 289/717 (40%), Gaps = 99/717 (13%)

Query: 152 ATMLCAASGNPDPEITWFKD--------FLPVDPSASNG---RIKQLRSGALQIESSEET 200
           A+ +C A+G+P P +TW K         F  ++   S G   RI+ LR+           
Sbjct: 50  ASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAGAVLRIQPLRT---------PR 100

Query: 201 DQGKYECVATNSAGVRYSSPANLYV----RVRRVAPRFSILPMSHEIMPGGNVNITCVAV 256
           D+  YECVA NS G   +  A L V    ++    P   + P    +       + C A 
Sbjct: 101 DENVYECVAQNSVG-EITVHAKLTVLREDQLPSGFPNIDMGPQLKVVERTRTATMLCAAS 159

Query: 257 GSPMPYVKWMQGAEDLTPE------DDMPVGRNVLELTDVKDSANYTCVAMSSLGV-IEA 309
           G+P P + W +    + P         +  G   +E ++  D   Y CVA +S GV   +
Sbjct: 160 GNPDPEITWFKDFLPVDPSASNGRIKQLRSGALQIESSEETDQGKYECVATNSAGVRYSS 219

Query: 310 VAQITVKSLPKAPG---TPMVTE-NTATSITITWDS-GNPDPVSYYVIEYKSKSQDGPYQ 364
            A + V+    AP     PM  E     ++ IT  + G+P P     +++   ++D    
Sbjct: 220 PANLYVRVRRVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPY----VKWMQGAED--LT 273

Query: 365 IKEDITTTRYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARM 424
            ++D+   R  +              A++S+G     E+V   T +  P  AP       
Sbjct: 274 PEDDMPVGRNVLELTDVKDSANYTCVAMSSLGV---IEAVAQITVKSLP-KAPGTPMVTE 329

Query: 425 LSATTMIVQWE----EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTT---VGS 477
            +AT++ + W+    +PV           YY +E +    +   + + + + TT   +G 
Sbjct: 330 NTATSITITWDSGNPDPVS----------YYVIEYKSKSQDGP-YQIKEDITTTRYSIGG 378

Query: 478 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSPPR 536
           L  +  Y + V A  S+G GP S+ +  +T +  P   P N++A   S T++ + W  P 
Sbjct: 379 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 438

Query: 537 QES--IIKYELLFR-EGDH--GREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGA 591
           + +  I  Y + +  E +H  G       D +    V  L  +  Y  R+ A +  G G 
Sbjct: 439 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498

Query: 592 FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSE 651
            +  ++ +T Q  P  P  +++  +   T+I +SW PP  E+         ++Y  L  E
Sbjct: 499 LSDPIQVKTQQGVPGQP-MNLRAEARSETSITLSWSPPRQES--------IIKYELLFRE 549

Query: 652 DPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPP 711
               +EV      TT  ++E L+  T+Y     A +  G G  +  V  RT   + S  P
Sbjct: 550 GDHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRT---LQSISP 606

Query: 712 RKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRME-GAEARGPPRIKDVMLADAQ 770
           +  + + +  T++ + W  P     +     Y++ Y  +    + R              
Sbjct: 607 KNFKVKMIMKTSVLLSWEFP---DNYNSPTPYKIQYNGLTLDVDGR------------TT 651

Query: 771 EMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLL 827
           + +IT+L+P T Y+  +        G +           + G+P+++ +   +G ++
Sbjct: 652 KKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIM 708


>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform 5
            precursor [Homo sapiens]
          Length = 1502

 Score = 1519 bits (3932), Expect = 0.0
 Identities = 797/1270 (62%), Positives = 950/1270 (74%), Gaps = 42/1270 (3%)

Query: 648  LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 707
            LG+ED  P++   +P     + L  + +   Y  T VA + +G     + + V+    +P
Sbjct: 268  LGAEDLTPED--DMPIGRNVLELNDVRQSANY--TCVAMSTLGVIEAIAQITVKA---LP 320

Query: 708  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 767
              P   V  E+  AT+I + W S  P           V Y  ++          K++   
Sbjct: 321  KPPGTPVVTES-TATSITLTWDSGNPE---------PVSYYIIQHKPKNSEELYKEIDGV 370

Query: 768  DAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGS-- 825
                  +  L P + Y   V A    G G  S+P +  T           VQ     S  
Sbjct: 371  ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT 430

Query: 826  LLARWEPPAGTAEDQVLGYRLQFGREDSTPLAT-LEFPPSEDRYTASG-VHKGATYVFRL 883
            +L +W+ P      Q+ GYR+ +  + +  +   ++   ++ + T  G +    TY  ++
Sbjct: 431  ILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKV 489

Query: 884  AARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKY 943
             A +  G G  ++++  I +    G P   +A   +   ++LL W PP    R+  I  Y
Sbjct: 490  LAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET-SILLSWTPP----RSDTIANY 544

Query: 944  TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1003
             +  ++ G  G  +   +    EPG   +  LQGLKP++ Y  ++ A + +G G  +  +
Sbjct: 545  ELVYKD-GEHGEEQRITI----EPGT--SYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 597

Query: 1004 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTK 1061
              RT     +  KNF VK +MKTSVLLSWE P+NYNS  P+KI Y+   +  +VDGR T+
Sbjct: 598  SARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQ 655

Query: 1062 KLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLP 1121
            KLI +LKP   Y+FVLTNRG+S GGLQ  VTA TA ++L  KP+   K + DG I V LP
Sbjct: 656  KLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLP 715

Query: 1122 DGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLE 1181
            +  +   ++ Y+I++VPL+KSRG +F+ P  SP++M+L+EL+++ISR +RRS+R+ R++E
Sbjct: 716  EVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVE 773

Query: 1182 VPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPF 1240
            + +PYIAA F VLP  F  GD K YGGF N+ L+ G  YV FVLAV++ +E   +A SP+
Sbjct: 774  L-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPY 832

Query: 1241 SDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTK 1300
            SDP    + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK+KPD KR +S+ R  
Sbjct: 833  SDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKSKPDRKRAESDSRKS 892

Query: 1301 CLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYE 1360
             + NN ++  HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERLKAND+LK SQEYE
Sbjct: 893  SIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYE 952

Query: 1361 SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQ 1420
            SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L  IEGI GSDY+NANY+DGYR Q
Sbjct: 953  SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQ 1012

Query: 1421 NAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQV 1480
            NAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QV
Sbjct: 1013 NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQV 1072

Query: 1481 TLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN 1540
            TLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCN
Sbjct: 1073 TLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCN 1132

Query: 1541 PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQY 1600
            PPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY
Sbjct: 1133 PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1192

Query: 1601 SFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFI 1660
             FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFI
Sbjct: 1193 IFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFI 1252

Query: 1661 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720
            SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA
Sbjct: 1253 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1312

Query: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1780
            ETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY
Sbjct: 1313 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1372

Query: 1781 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1840
            ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV
Sbjct: 1373 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1432

Query: 1841 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1900
            HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALE
Sbjct: 1433 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE 1492

Query: 1901 YLGSFDHYAT 1910
            YLGSFDHYAT
Sbjct: 1493 YLGSFDHYAT 1502



 Score =  884 bits (2285), Expect = 0.0
 Identities = 455/738 (61%), Positives = 557/738 (75%), Gaps = 28/738 (3%)

Query: 29  AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
           AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20  AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 89  AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
           +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80  SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRSG------ALQIESSEETDQ 202
           TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRSG      ALQIE SEE+DQ
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSGGTPIRGALQIEQSEESDQ 199

Query: 203 GKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVAVGS 258
           GKYECVATNSAG RYS+PANLYVR    VRRV PRFSI P +HEIMPGG+VNITCVAVGS
Sbjct: 200 GKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGS 259

Query: 259 PMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITVKSL 318
           PMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITVK+L
Sbjct: 260 PMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKAL 319

Query: 319 PKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGG 378
           PK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS+ G
Sbjct: 320 PKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYSVAG 379

Query: 379 LSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPV 438
           LSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+EP 
Sbjct: 380 LSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPE 439

Query: 439 EPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVGDGP 498
           EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+GDGP
Sbjct: 440 EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGP 499

Query: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGR 558
           LS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E   
Sbjct: 500 LSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEEQRI 559

Query: 559 TFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVR 618
           T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QS  +   ++    +V 
Sbjct: 560 TIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA---KNFHVKAVM 616

Query: 619 STAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQ 678
            T++L+SW    PE +N A+      ++ L  +    +EV+G     TQ L+  L+    
Sbjct: 617 KTSVLLSWE--IPENYNSAM-----PFKILYDDGKMVEEVDG---RATQKLIVNLKPEKS 666

Query: 679 YRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 738
           Y            G +   V  +T  DV    P  +    L+      L   PA    + 
Sbjct: 667 YSFVLTNRGNSAGGLQHR-VTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA----NE 721

Query: 739 QIRGYQVHYVRMEGAEAR 756
            I+GY +  V ++ +  +
Sbjct: 722 NIKGYYIIIVPLKKSRGK 739


>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform 4
            precursor [Homo sapiens]
          Length = 1501

 Score = 1506 bits (3899), Expect = 0.0
 Identities = 794/1270 (62%), Positives = 946/1270 (74%), Gaps = 46/1270 (3%)

Query: 648  LGSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVP 707
            LG+ED  P++   +P     + L  + +   Y  T VA + +G     + + V+    +P
Sbjct: 271  LGAEDLTPED--DMPIGRNVLELNDVRQSANY--TCVAMSTLGVIEAIAQITVKA---LP 323

Query: 708  SAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLA 767
              P   V  E+  AT+I + W S  P           V Y  ++          K++   
Sbjct: 324  KPPGTPVVTES-TATSITLTWDSGNPE---------PVSYYIIQHKPKNSEELYKEIDGV 373

Query: 768  DAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGS-- 825
                  +  L P + Y   V A    G G  S+P +  T           VQ     S  
Sbjct: 374  ATTRYSVAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTT 433

Query: 826  LLARWEPPAGTAEDQVLGYRLQFGREDSTPLAT-LEFPPSEDRYTASG-VHKGATYVFRL 883
            +L +W+ P      Q+ GYR+ +  + +  +   ++   ++ + T  G +    TY  ++
Sbjct: 434  ILVQWKEPE-EPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKV 492

Query: 884  AARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKY 943
             A +  G G  ++++  I +    G P   +A   +   ++LL W PP    R+  I  Y
Sbjct: 493  LAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESET-SILLSWTPP----RSDTIANY 547

Query: 944  TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1003
             +  ++ G  G  +   +    EPG   +  LQGLKP++ Y  ++ A + +G G  +  +
Sbjct: 548  ELVYKD-GEHGEEQRITI----EPGT--SYRLQGLKPNSLYYFRLAARSPQGLGASTAEI 600

Query: 1004 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNG--LTLDVDGRTTK 1061
              RT     +  KNF VK +MKTSVLLSWE P+NYNS  P+KI Y+   +  +VDGR T+
Sbjct: 601  SARTM--QSMFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQ 658

Query: 1062 KLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPDADGFIMVYLP 1121
            KLI +LKP   Y+FVLTNRG+S GGLQ  VTA TA ++L  KP+   K + DG I V LP
Sbjct: 659  KLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLP 718

Query: 1122 DGQSPVPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLE 1181
            +  +   ++ Y+I++VPL+KSRG +F+ P  SP++M+L+EL+++ISR +RRS+R+ R++E
Sbjct: 719  EVPANENIKGYYIIIVPLKKSRG-KFIKPWESPDEMELDELLKEISR-KRRSIRYGREVE 776

Query: 1182 VPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT-FAASPF 1240
            + +PYIAA F VLP  F  GD K YGGF N+ L+ G  YV FVLAV++ +E   +A SP+
Sbjct: 777  L-KPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMEHAESKMYATSPY 835

Query: 1241 SDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTK 1300
            SDP    + DPQPI D EEGLIWV+GPVLAVVFIICIVIAILLYK K    R +S+ R  
Sbjct: 836  SDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRK----RAESDSRKS 891

Query: 1301 CLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYE 1360
             + NN ++  HHP DPVE+RR+NFQTPGM SHPPIPI ++A+H ERLKAND+LK SQEYE
Sbjct: 892  SIPNNKEIPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYE 951

Query: 1361 SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQ 1420
            SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRV+L  IEGI GSDY+NANY+DGYR Q
Sbjct: 952  SIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQ 1011

Query: 1421 NAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQV 1480
            NAYIATQG LPETFGDFWRM+WEQRSAT+VMMT+LEE+SR+KCDQYWP+RGTET+G +QV
Sbjct: 1012 NAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQV 1071

Query: 1481 TLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCN 1540
            TLLDT+ELAT+CVRTF+L+KNGSSEKREVRQFQFTAWPDHGVPE+PTPFLAFLRRVKTCN
Sbjct: 1072 TLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCN 1131

Query: 1541 PPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQY 1600
            PPDAGP+VVHCSAGVGRTGCFIVIDAMLERIK EKTVD+YGHVTLMR+QRNYMVQTEDQY
Sbjct: 1132 PPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQY 1191

Query: 1601 SFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFI 1660
             FIH+ALLEAV CGNTEVPAR+LYAYIQKL Q+E GE+VTGMELEFKRLA+SKAHTSRFI
Sbjct: 1192 IFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFI 1251

Query: 1661 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720
            SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA
Sbjct: 1252 SANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1311

Query: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1780
            ETTEDFWRMLWE+NSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY
Sbjct: 1312 ETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQY 1371

Query: 1781 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1840
            ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV
Sbjct: 1372 ILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISV 1431

Query: 1841 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1900
            HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTED+YQF Y+AALE
Sbjct: 1432 HCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFSYRAALE 1491

Query: 1901 YLGSFDHYAT 1910
            YLGSFDHYAT
Sbjct: 1492 YLGSFDHYAT 1501



 Score =  883 bits (2282), Expect = 0.0
 Identities = 455/741 (61%), Positives = 557/741 (75%), Gaps = 31/741 (4%)

Query: 29  AEEPPRFIKEPKDQIGVSGGVASFVCQATGDPKPRVTWNKKGKKVNSQRFETIEFDESAG 88
           AE PPRF + P DQ GVSGGVASF+CQATGDP+P++ WNKKGKKV++QRFE IEFD+ +G
Sbjct: 20  AETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSG 79

Query: 89  AVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPNIDMGPQLKVVER 148
           +VLRIQPLRTPRDE +YECVA N+VGEI+V  +LTVLREDQ+P GFP IDMGPQLKVVER
Sbjct: 80  SVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVER 139

Query: 149 TRTATMLCAASGNPDPEITWFKDFLPVDPSASNGRIKQLRS---------GALQIESSEE 199
           TRTATMLCAASGNPDPEITWFKDFLPVD S +NGRIKQLRS         GALQIE SEE
Sbjct: 140 TRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEE 199

Query: 200 TDQGKYECVATNSAGVRYSSPANLYVR----VRRVAPRFSILPMSHEIMPGGNVNITCVA 255
           +DQGKYECVATNSAG RYS+PANLYVR    VRRV PRFSI P +HEIMPGG+VNITCVA
Sbjct: 200 SDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVA 259

Query: 256 VGSPMPYVKWMQGAEDLTPEDDMPVGRNVLELTDVKDSANYTCVAMSSLGVIEAVAQITV 315
           VGSPMPYVKWM GAEDLTPEDDMP+GRNVLEL DV+ SANYTCVAMS+LGVIEA+AQITV
Sbjct: 260 VGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITV 319

Query: 316 KSLPKAPGTPMVTENTATSITITWDSGNPDPVSYYVIEYKSKSQDGPYQIKEDITTTRYS 375
           K+LPK PGTP+VTE+TATSIT+TWDSGNP+PVSYY+I++K K+ +  Y+  + + TTRYS
Sbjct: 320 KALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEELYKEIDGVATTRYS 379

Query: 376 IGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWE 435
           + GLSP S+YE  V AVN+IG+GPPSE V+T+T EQAP+SAPR+VQARMLS+TT++VQW+
Sbjct: 380 VAGLSPYSDYEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWK 439

Query: 436 EPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLEDETYTVRVLAFTSVG 495
           EP EPNG I+GYRVYYTM+P   V NW KHNV DS +TT+G+L+  +TY+V+VLAFTS+G
Sbjct: 440 EPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIG 499

Query: 496 DGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGRE 555
           DGPLS  IQV TQ GVPGQP+N +AE  SETSI LSW+PPR ++I  YEL++++G+HG E
Sbjct: 500 DGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIANYELVYKDGEHGEE 559

Query: 556 VGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCV 615
              T +P TSY ++ LKPN+ Y FRLAARSPQGLGA T  +  RT+QS  +   ++    
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSMFA---KNFHVK 616

Query: 616 SVRSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEK 675
           +V  T++L+SW    PE +N A+      ++ L  +    +EV+G     TQ L+  L+ 
Sbjct: 617 AVMKTSVLLSWE--IPENYNSAM-----PFKILYDDGKMVEEVDG---RATQKLIVNLKP 666

Query: 676 WTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 735
              Y            G +   V  +T  DV    P  +    L+      L   PA   
Sbjct: 667 EKSYSFVLTNRGNSAGGLQHR-VTAKTAPDVLRTKPAFIGKTNLDGMITVQLPEVPA--- 722

Query: 736 QHGQIRGYQVHYVRMEGAEAR 756
            +  I+GY +  V ++ +  +
Sbjct: 723 -NENIKGYYIIIVPLKKSRGK 742


>gi|4506303 protein tyrosine phosphatase, receptor type, A isoform 1
            precursor [Homo sapiens]
          Length = 802

 Score =  592 bits (1525), Expect = e-168
 Identities = 312/682 (45%), Positives = 426/682 (62%), Gaps = 22/682 (3%)

Query: 1234 TFAASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRK 1293
            TF  S  SD    D  D  PI+     ++  +  +L +VFII ++  +   K K      
Sbjct: 134  TFPPSGNSD--SKDRRDETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHS 187

Query: 1294 DSEPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDS 1352
            +S       L+N       P+    + R    +P     +PP+P+  + E   R  A+D+
Sbjct: 188  NS-----FRLSNGRTEDVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDN 238

Query: 1353 LKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1411
                +E+ ++     Q T E ++ E NK KNRY N++ YDHSRV L P+EG+  SDYINA
Sbjct: 239  KLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINA 298

Query: 1412 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1471
            ++++GY+ +N +IA QGP  ET  DFWRM+WEQ +ATIVM+T L+E+   KC QYWP++G
Sbjct: 299  SFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG 358

Query: 1472 TETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPT 1527
              TYG I+V++ D   L  + VR F + + G    R+    + QF FT+WPD GVP  P 
Sbjct: 359  CWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPI 418

Query: 1528 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1587
              L FL++VK CNP  AG IVVHCSAGVGRTG F+VIDAML+ +  E+ VDVYG V+ +R
Sbjct: 419  GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIR 478

Query: 1588 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1647
            +QR  MVQT+ QY FI++ALLE    G+TE+   SL  ++QK+    PG    G+E EFK
Sbjct: 479  AQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFK 538

Query: 1648 RLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYR 1707
            +L + K    +  + NLP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYR
Sbjct: 539  KLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYR 598

Query: 1708 QQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYF 1767
            Q+ +YIA+QGPL  T EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y   
Sbjct: 599  QKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDI 658

Query: 1768 VVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHK 1827
             V+   E     Y +R+  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K
Sbjct: 659  TVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK 718

Query: 1828 TKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQT 1887
             ++Q G + PI+VHCSAG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT
Sbjct: 719  QQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQT 777

Query: 1888 EDEYQFCYQAALEYLGSFDHYA 1909
             ++Y+FCY+   EY+ +F  YA
Sbjct: 778  LEQYEFCYKVVQEYIDAFSDYA 799


>gi|18450371 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  589 bits (1518), Expect = e-167
 Identities = 306/666 (45%), Positives = 420/666 (63%), Gaps = 20/666 (3%)

Query: 1250 DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA 1309
            D  PI+     ++  +  +L +VFII ++  +   K K      +S       L+N    
Sbjct: 139  DETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS-----FRLSNGRTE 189

Query: 1310 PHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-Q 1367
               P+    + R    +P     +PP+P+  + E   R  A+D+    +E+ ++     Q
Sbjct: 190  DVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQ 245

Query: 1368 FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1427
             T E ++ E NK KNRY N++ YDHSRV L P+EG+  SDYINA++++GY+ +N +IA Q
Sbjct: 246  ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQ 305

Query: 1428 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1487
            GP  ET  DFWRM+WEQ +ATIVM+T L+E+   KC QYWP++G  TYG I+V++ D   
Sbjct: 306  GPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTV 365

Query: 1488 LATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1543
            L  + VR F + + G    R+    + QF FT+WPD GVP  P   L FL++VK CNP  
Sbjct: 366  LVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY 425

Query: 1544 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1603
            AG IVVHCSAGVGRTG F+VIDAML+ +  E+ VDVYG V+ +R+QR  MVQT+ QY FI
Sbjct: 426  AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFI 485

Query: 1604 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISAN 1663
            ++ALLE    G+TE+   SL  ++QK+    PG    G+E EFK+L + K    +  + N
Sbjct: 486  YQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGN 545

Query: 1664 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1723
            LP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ +YIA+QGPL  T 
Sbjct: 546  LPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTI 605

Query: 1724 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1783
            EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+   E     Y +R
Sbjct: 606  EDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVR 665

Query: 1784 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCS 1843
            +  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++Q G + PI+VHCS
Sbjct: 666  DLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCS 724

Query: 1844 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1903
            AG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT ++Y+FCY+   EY+ 
Sbjct: 725  AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784

Query: 1904 SFDHYA 1909
            +F  YA
Sbjct: 785  AFSDYA 790


>gi|18450369 protein tyrosine phosphatase, receptor type, A isoform 2
            precursor [Homo sapiens]
          Length = 793

 Score =  589 bits (1518), Expect = e-167
 Identities = 306/666 (45%), Positives = 420/666 (63%), Gaps = 20/666 (3%)

Query: 1250 DPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNNADLA 1309
            D  PI+     ++  +  +L +VFII ++  +   K K      +S       L+N    
Sbjct: 139  DETPII----AVMVALSSLLVIVFIIIVLYMLRFKKYKQAGSHSNS-----FRLSNGRTE 189

Query: 1310 PHHPKDPVEMRRINFQTPGM-LSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-Q 1367
               P+    + R    +P     +PP+P+  + E   R  A+D+    +E+ ++     Q
Sbjct: 190  DVEPQSVPLLAR----SPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQ 245

Query: 1368 FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1427
             T E ++ E NK KNRY N++ YDHSRV L P+EG+  SDYINA++++GY+ +N +IA Q
Sbjct: 246  ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQ 305

Query: 1428 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1487
            GP  ET  DFWRM+WEQ +ATIVM+T L+E+   KC QYWP++G  TYG I+V++ D   
Sbjct: 306  GPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTV 365

Query: 1488 LATFCVRTFSLHKNGSSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1543
            L  + VR F + + G    R+    + QF FT+WPD GVP  P   L FL++VK CNP  
Sbjct: 366  LVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY 425

Query: 1544 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1603
            AG IVVHCSAGVGRTG F+VIDAML+ +  E+ VDVYG V+ +R+QR  MVQT+ QY FI
Sbjct: 426  AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFI 485

Query: 1604 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISAN 1663
            ++ALLE    G+TE+   SL  ++QK+    PG    G+E EFK+L + K    +  + N
Sbjct: 486  YQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGN 545

Query: 1664 LPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETT 1723
            LP N  KNR++ I+PYE  RV +   RG E +DY+NASFIDGYRQ+ +YIA+QGPL  T 
Sbjct: 546  LPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTI 605

Query: 1724 EDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILR 1783
            EDFWRM+WE  S  +VMLT+L E G+EKC QYWP++    Y    V+   E     Y +R
Sbjct: 606  EDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVR 665

Query: 1784 EFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCS 1843
            +  VT+ R+ +SR +RQF F  WPE G+P  G+G I  I  V K ++Q G + PI+VHCS
Sbjct: 666  DLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCS 724

Query: 1844 AGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLG 1903
            AG GRTG F  LS VLER++ EG++D+FQTVK LR QRP MVQT ++Y+FCY+   EY+ 
Sbjct: 725  AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID 784

Query: 1904 SFDHYA 1909
            +F  YA
Sbjct: 785  AFSDYA 790


>gi|5729993 protein tyrosine phosphatase, receptor type, E isoform 1
            precursor [Homo sapiens]
          Length = 700

 Score =  552 bits (1423), Expect = e-156
 Identities = 297/676 (43%), Positives = 416/676 (61%), Gaps = 32/676 (4%)

Query: 1249 PDP---QPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN 1305
            PDP   QP+      L W++ P+L ++ ++ +      ++ +  +    S+ +       
Sbjct: 39   PDPGASQPL------LAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKM------ 86

Query: 1306 ADLAPHHPKDPVEMRRINFQT---PGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESI 1362
                P+   +  E +R+   +    G   + PIP+  + E      A+D  +  +E+ S+
Sbjct: 87   ----PNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSL 142

Query: 1363 DPGQ-QFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQN 1421
              G  Q T+E +N E N+ KNRY N++  DHSRVIL  ++GI  SDYINA+Y+DGY+ +N
Sbjct: 143  PSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKN 202

Query: 1422 AYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVT 1481
             +IA QGP  ET  DFWRMVWEQ+SATIVM+T L+E+   KC QYWP++G  TYG I+V 
Sbjct: 203  KFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVC 262

Query: 1482 LLDTIELATFCVRTFSLHK---NGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT 1538
            + D + L  + +R F +     +G    R V Q  FT+WPD GVP  P   L FL++VKT
Sbjct: 263  VEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKT 322

Query: 1539 CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1598
             NP  AGPIVVHCSAGVGRTG FIVIDAM+  +  E+ VDV+  V+ +R+QR  MVQT+ 
Sbjct: 323  LNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDM 382

Query: 1599 QYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSR 1658
            QY+FI++ALLE    G+TE+   SL  ++Q +          G+E EF++L N +     
Sbjct: 383  QYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKEN 442

Query: 1659 FISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGP 1718
              + NLP N  K R++ I+PY+  RV L   RG E +DYINASFIDGYRQ+  +IATQGP
Sbjct: 443  MRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGP 502

Query: 1719 LAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMP 1778
            LA T EDFWRM+WE  S  +VMLT+++E  ++KC+QYWP E S  +    ++   +    
Sbjct: 503  LAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSE 562

Query: 1779 QYILREFKVT-----DARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFG 1833
               +R+F VT       ++ Q R VRQF F  WPE G+P  G+G ID I  V K ++Q G
Sbjct: 563  AISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTG 622

Query: 1834 QDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQF 1893
             + PI+VHCSAG GRTG FI LS +LER++ EG++D+FQ VK LR QRP MVQT ++Y+F
Sbjct: 623  -NHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEF 681

Query: 1894 CYQAALEYLGSFDHYA 1909
            CY+   +++  F  YA
Sbjct: 682  CYKVVQDFIDIFSDYA 697


>gi|18860859 protein tyrosine phosphatase, receptor type, E isoform 2
            [Homo sapiens]
          Length = 642

 Score =  549 bits (1414), Expect = e-155
 Identities = 283/585 (48%), Positives = 381/585 (65%), Gaps = 10/585 (1%)

Query: 1334 PIPIADMAEHTERLKANDSLKLSQEYESIDPGQ-QFTWEHSNLEVNKPKNRYANVIAYDH 1392
            PIP+  + E      A+D  +  +E+ S+  G  Q T+E +N E N+ KNRY N++  DH
Sbjct: 56   PIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDH 115

Query: 1393 SRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMM 1452
            SRVIL  ++GI  SDYINA+Y+DGY+ +N +IA QGP  ET  DFWRMVWEQ+SATIVM+
Sbjct: 116  SRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVML 175

Query: 1453 TRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHK---NGSSEKREV 1509
            T L+E+   KC QYWP++G  TYG I+V + D + L  + +R F +     +G    R V
Sbjct: 176  TNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLV 235

Query: 1510 RQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLE 1569
             Q  FT+WPD GVP  P   L FL++VKT NP  AGPIVVHCSAGVGRTG FIVIDAM+ 
Sbjct: 236  SQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMA 295

Query: 1570 RIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQK 1629
             +  E+ VDV+  V+ +R+QR  MVQT+ QY+FI++ALLE    G+TE+   SL  ++Q 
Sbjct: 296  MMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQT 355

Query: 1630 LAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1689
            +          G+E EF++L N +       + NLP N  K R++ I+PY+  RV L   
Sbjct: 356  MHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMK 415

Query: 1690 RGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGR 1749
            RG E +DYINASFIDGYRQ+  +IATQGPLA T EDFWRM+WE  S  +VMLT+++E  +
Sbjct: 416  RGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQ 475

Query: 1750 EKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVT-----DARDGQSRTVRQFQFT 1804
            +KC+QYWP E S  +    ++   +       +R+F VT       ++ Q R VRQF F 
Sbjct: 476  DKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFH 535

Query: 1805 DWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRY 1864
             WPE G+P  G+G ID I  V K ++Q G + PI+VHCSAG GRTG FI LS +LER++ 
Sbjct: 536  GWPEIGIPAEGKGMIDLIAAVQKQQQQTG-NHPITVHCSAGAGRTGTFIALSNILERVKA 594

Query: 1865 EGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGSFDHYA 1909
            EG++D+FQ VK LR QRP MVQT ++Y+FCY+   +++  F  YA
Sbjct: 595  EGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYA 639


>gi|18860902 protein tyrosine phosphatase, receptor type, K isoform b
            [Homo sapiens]
          Length = 1440

 Score =  513 bits (1321), Expect = e-145
 Identities = 349/987 (35%), Positives = 507/987 (51%), Gaps = 126/987 (12%)

Query: 1011 DQVSPKNFKVKMIMKTS----VLLSWEFPDNYNSP-TPYKIQYNGL-------------- 1051
            D+  P    VK +  TS    + L+W+ P + N   T Y+I Y+ +              
Sbjct: 486  DEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQ 545

Query: 1052 TLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPD 1111
            T+     +T  +  HL P T Y F +  R S++ G           N+     S    PD
Sbjct: 546  TVSNLWNSTHHVFMHLHPGTTYQFFI--RASTVKGFGPATAINVTTNI-----SAPTLPD 598

Query: 1112 ADGF----------IMVYLPDGQSP-VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE 1160
             +G           I V L   Q+   P+ +Y IV+  L   R  +     G+ E   + 
Sbjct: 599  YEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKR---EAGAMECYQVP 655

Query: 1161 ELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPP-------TFHPGDQKQYGGFDNRG 1213
               Q+              +    PY  A  + LPP        F  GD + Y GF N  
Sbjct: 656  VTYQNA-------------MSGGAPYYFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPP 700

Query: 1214 LEPGHRYVLFVLAVLQKSEPTFA--------ASPFSDPFQLDNPDPQPIVDGEEGLIWVI 1265
            L P   Y ++  A+    + T          A+   +P  +  PDP    D    +  + 
Sbjct: 701  LAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI--PDPAKQTDRVVKIAGIS 758

Query: 1266 GPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN---------ADLAPHHPKDP 1316
              +L  + ++ +VI +++ K+K   KRKD+   T+  + +         AD +  H +DP
Sbjct: 759  AGILVFILLLLVVI-LIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDP 817

Query: 1317 VE---MRRINFQ-----------------TPGMLS------------HPPIPIADMAEHT 1344
            +    M + NF                   P  L             HP I +AD+ +H 
Sbjct: 818  LSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHI 877

Query: 1345 ERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIM 1404
              +K +DS    +EYES   GQ  +W+ +  + N+ KNRY N+IAYDHSRVILQP+E   
Sbjct: 878  NLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDP 937

Query: 1405 GSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCD 1464
             SDYINANY+DGY+  + YIATQGP+ ET  DFWRM+W+++SA IVM+T L E  R+KC 
Sbjct: 938  SSDYINANYIDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCY 997

Query: 1465 QYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPE 1524
            +YWP+  TE YG  +VT ++   LA + VRTF+L + G +E REV+QF FT WPDHGVP 
Sbjct: 998  KYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPY 1056

Query: 1525 YPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVT 1584
            + T  L+F+RRVK  NPP AGPIVVHCSAG GRTGC+IVID ML+  + E  VD+Y  V 
Sbjct: 1057 HATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVK 1116

Query: 1585 LMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMEL 1644
             +RS+R  MVQTE+QY FIH+A+LEA  CG T +P     A    + +++   + + ++ 
Sbjct: 1117 ALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKD 1176

Query: 1645 EFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASF 1702
            EF+ L     +        A LP N  KNR ++++P +     L  I G E S+YINA+ 
Sbjct: 1177 EFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAAL 1235

Query: 1703 IDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSA 1762
            +D YRQ  A+I TQ PL  T +DFWR++++   T +VML ++     + C QYWP E   
Sbjct: 1236 MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGML 1293

Query: 1763 RYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQFQFTDW-PEQGVPKSGEGF 1818
            RY    V+ M+   + ++   I R   +T  ++G    V+QFQ+  W   + VP S   F
Sbjct: 1294 RYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQFQYLGWASHREVPGSKRSF 1352

Query: 1819 IDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKML 1877
            +  I QV K +E+  + +G   +HC  G GR+G+F  + IV+E ++ + VVD+F  VK L
Sbjct: 1353 LKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTL 1412

Query: 1878 RTQRPAMVQTEDEYQFCYQAALEYLGS 1904
            R  +P MV+  ++Y+FCY  ALEYL S
Sbjct: 1413 RNSKPNMVEAPEQYRFCYDVALEYLES 1439



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 100/450 (22%), Positives = 167/450 (37%), Gaps = 70/450 (15%)

Query: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 288
           E+  G N    C+A G    + K W+Q        +D+PV   +N+          L+  
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260

Query: 289 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 344
              D   Y CV  S  G  +   AQ+ V+  P+    P +     T + I  ++ +    
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 345 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 402
            P+    +EY+  S  G +     +    Y +  L P++EYEI V  +     G G P  
Sbjct: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 460
            ++TRT    P   P+ ++   + A  + V WE          GY +   +T        
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 461 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 512
            ++ HN        +D      V + L   T     +  T+      S+   ++T + VP
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490

Query: 513 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 562
           G  P+        E  I L+W  P   +  I +YE+ +          R+FDP       
Sbjct: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543

Query: 563 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVK 613
                    +T +V   L P T Y F + A + +G G  T  +   T  S P+ P  +  
Sbjct: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGV 602

Query: 614 CVSVRSTAILVSWRPPPPETHNGALVGYSV 643
             S+  TA  ++    P +     +  Y +
Sbjct: 603 DASLNETATTITVLLRPAQAKGAPISAYQI 632



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)

Query: 320 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 372
           + P T  + E  A  I + W+S   +    +          ++  ++     +  D    
Sbjct: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450

Query: 373 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 432
           ++ +  L P +   + +   N  G+   SE  + +T E  P   P            + +
Sbjct: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509

Query: 433 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 486
            W+EP++PNG+I  Y + Y    + +P  PV    +   N+ +S       L    TY  
Sbjct: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569

Query: 487 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 541
            + A T  G GP +  I V T    P  P     +A    + T+IT+   P + +   I 
Sbjct: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628

Query: 542 KYELLFRE 549
            Y+++  E
Sbjct: 629 AYQIVVEE 636



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 101/420 (24%), Positives = 157/420 (37%), Gaps = 55/420 (13%)

Query: 565 SYVVEDLKPNTEYAFRLAARSPQGLGAFT---PVVRQRTLQSKPSAPPQDVKCVSVRSTA 621
           S+ ++++    +  +R   +S +G G       +VR+     +P APPQ    + V  T 
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQ---LLGVGPTY 307

Query: 622 ILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQY-- 679
           +L+          +G ++   V YR       E   VN   PT     L  L+  T+Y  
Sbjct: 308 LLIQLNANSI-IGDGPIILKEVEYRMTSGSWTETHAVNA--PTYK---LWHLDPDTEYEI 361

Query: 680 RITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQ 739
           R+      E G G    P++ RT    P   P+ ++   + A  I V W S         
Sbjct: 362 RVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCH 421

Query: 740 IRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARS 799
                + Y    G        +   M   A + V+ +L P T  S+ +     +G    S
Sbjct: 422 TFNVTICYHYFRGHNESKADCLD--MDPKAPQHVVNHLPPYTNVSLKMILTNPEG-RKES 478

Query: 800 KPKVVVTKGAVLGR-PTLSVQQTP-EGSLLARW-EP--PAGTAEDQVLGYRLQFGREDST 854
           +  ++ T   V G  P  S+Q T  E  +   W EP  P G      + Y      + + 
Sbjct: 479 EETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAV 538

Query: 855 PLA----TLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHP 910
           P+A    T+    +   +    +H G TY F + A +  G G   A    I   T    P
Sbjct: 539 PVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA----INVTTNISAP 594

Query: 911 QILEAAG-------NASAGTVLLRWLPPVPAERNGA-IVKYTVAV---------REAGAL 953
            + +  G        A+  TVLLR     PA+  GA I  Y + V         REAGA+
Sbjct: 595 TLPDYEGVDASLNETATTITVLLR-----PAQAKGAPISAYQIVVEELHPHRTKREAGAM 649



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 50/242 (20%), Positives = 86/242 (35%), Gaps = 31/242 (12%)

Query: 776 NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAG 835
           +L P+T Y I V   T  G+G    P   +        P     +TP+   +A  +    
Sbjct: 352 HLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEP----MRTPKTLKIAEIQARRI 406

Query: 836 TAEDQVLGYRLQ-------------FGREDSTPLATLEFPPSEDRYTASGVHKGATYVFR 882
             + + LGY +              F   + +    L+  P   ++  + +        +
Sbjct: 407 AVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLK 466

Query: 883 LAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVK 942
           +   +  G  E    ++   ED P G   +    G +    + L W  P+  + NG I +
Sbjct: 467 MILTNPEGRKESEETIIQTDEDVP-GPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQ 523

Query: 943 YTVAVREAGALGPARETELPAAAEPGAENAL------TLQGLKPDTAYDLQVRAHTRRGP 996
           Y ++     +  PA    +P A  P   + L          L P T Y   +RA T +G 
Sbjct: 524 YEISYSSIRSFDPA----VPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGF 579

Query: 997 GP 998
           GP
Sbjct: 580 GP 581



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 21/134 (15%)

Query: 966  EPGAENALT--LQGLKPDTAYDLQVRAHTRRGPGPFS---PPVRYRTFLRDQV-SPKNFK 1019
            E  A NA T  L  L PDT Y+++V   TR G G      PP+  RT   + + +PK  K
Sbjct: 339  ETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLK 397

Query: 1020 VKMIMKTSVLLSWEFPD-------NYNSPTPYKI-----QYNGLTLDVDGRTTKKLITHL 1067
            +  I    + + WE           +N    Y       +     LD+D +  + ++ HL
Sbjct: 398  IAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHL 457

Query: 1068 KPHT--FYNFVLTN 1079
             P+T      +LTN
Sbjct: 458  PPYTNVSLKMILTN 471



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)

Query: 30  EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
           ++ P F++    ++  +G  A+F C ATG D      W   + G+ +   + + I     
Sbjct: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251

Query: 87  AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
           A A  R+Q + T  D+++Y CV Q+  G    +    ++RE   P   P  + +GP   +
Sbjct: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309

Query: 146 VE 147
           ++
Sbjct: 310 IQ 311


>gi|208431815 protein tyrosine phosphatase, receptor type, K isoform a
            [Homo sapiens]
          Length = 1446

 Score =  506 bits (1304), Expect = e-143
 Identities = 349/993 (35%), Positives = 507/993 (51%), Gaps = 132/993 (13%)

Query: 1011 DQVSPKNFKVKMIMKTS----VLLSWEFPDNYNSP-TPYKIQYNGL-------------- 1051
            D+  P    VK +  TS    + L+W+ P + N   T Y+I Y+ +              
Sbjct: 486  DEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQ 545

Query: 1052 TLDVDGRTTKKLITHLKPHTFYNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSVAPKPD 1111
            T+     +T  +  HL P T Y F +  R S++ G           N+     S    PD
Sbjct: 546  TVSNLWNSTHHVFMHLHPGTTYQFFI--RASTVKGFGPATAINVTTNI-----SAPTLPD 598

Query: 1112 ADGF----------IMVYLPDGQSP-VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLE 1160
             +G           I V L   Q+   P+ +Y IV+  L   R  +     G+ E   + 
Sbjct: 599  YEGVDASLNETATTITVLLRPAQAKGAPISAYQIVVEELHPHRTKR---EAGAMECYQVP 655

Query: 1161 ELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPP-------TFHPGDQKQYGGFDNRG 1213
               Q+              +    PY  A  + LPP        F  GD + Y GF N  
Sbjct: 656  VTYQNA-------------MSGGAPYYFA--AELPPGNLPEPAPFTVGDNRTYQGFWNPP 700

Query: 1214 LEPGHRYVLFVLAVLQKSEPTFA--------ASPFSDPFQLDNPDPQPIVDGEEGLIWVI 1265
            L P   Y ++  A+    + T          A+   +P  +  PDP    D    +  + 
Sbjct: 701  LAPRKGYNIYFQAMSSVEKETKTQCVRIATKAAATEEPEVI--PDPAKQTDRVVKIAGIS 758

Query: 1266 GPVLAVVFIICIVIAILLYKNKPDSKRKDSEPRTKCLLNN---------ADLAPHHPKDP 1316
              +L  + ++ +VI +++ K+K   KRKD+   T+  + +         AD +  H +DP
Sbjct: 759  AGILVFILLLLVVI-LIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYADQSTLHAEDP 817

Query: 1317 VE---MRRINFQ-----------------TPGMLS------------HPPIPIADMAEHT 1344
            +    M + NF                   P  L             HP I +AD+ +H 
Sbjct: 818  LSITFMDQHNFSPRYENHSATAESSRLLDVPRYLCEGTESPYQTGQLHPAIRVADLLQHI 877

Query: 1345 ERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIM 1404
              +K +DS    +EYES   GQ  +W+ +  + N+ KNRY N+IAYDHSRVILQP+E   
Sbjct: 878  NLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDP 937

Query: 1405 GSDYINANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEK 1458
             SDYINANY+D      GY+  + YIATQGP+ ET  DFWRM+W+++SA IVM+T L E 
Sbjct: 938  SSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEV 997

Query: 1459 SRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWP 1518
             R+KC +YWP+  TE YG  +VT ++   LA + VRTF+L + G +E REV+QF FT WP
Sbjct: 998  GRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWP 1056

Query: 1519 DHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVD 1578
            DHGVP + T  L+F+RRVK  NPP AGPIVVHCSAG GRTGC+IVID ML+  + E  VD
Sbjct: 1057 DHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVD 1116

Query: 1579 VYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEH 1638
            +Y  V  +RS+R  MVQTE+QY FIH+A+LEA  CG T +P     A    + +++   +
Sbjct: 1117 IYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTN 1176

Query: 1639 VTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSD 1696
             + ++ EF+ L     +        A LP N  KNR ++++P +     L  I G E S+
Sbjct: 1177 SSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSN 1235

Query: 1697 YINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYW 1756
            YINA+ +D YRQ  A+I TQ PL  T +DFWR++++   T +VML ++     + C QYW
Sbjct: 1236 YINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYW 1293

Query: 1757 PAERSARYQYFVVDPMA---EYNMPQYILREFKVTDARDGQSRTVRQFQFTDW-PEQGVP 1812
            P E   RY    V+ M+   + ++   I R   +T  ++G    V+QFQ+  W   + VP
Sbjct: 1294 PEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY-LMVQQFQYLGWASHREVP 1352

Query: 1813 KSGEGFIDFIGQVHKTKEQFGQ-DGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIF 1871
             S   F+  I QV K +E+  + +G   +HC  G GR+G+F  + IV+E ++ + VVD+F
Sbjct: 1353 GSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVF 1412

Query: 1872 QTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1904
              VK LR  +P MV+  ++Y+FCY  ALEYL S
Sbjct: 1413 HAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES 1445



 Score = 72.8 bits (177), Expect = 3e-12
 Identities = 100/450 (22%), Positives = 167/450 (37%), Gaps = 70/450 (15%)

Query: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAEDLTPEDDMPVG--RNV----------LELT 288
           E+  G N    C+A G    + K W+Q        +D+PV   +N+          L+  
Sbjct: 205 EVNAGQNATFQCIATGRDAVHNKLWLQRRNG----EDIPVAQTKNINHRRFAASFRLQEV 260

Query: 289 DVKDSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---P 344
              D   Y CV  S  G  +   AQ+ V+  P+    P +     T + I  ++ +    
Sbjct: 261 TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLLIQLNANSIIGD 320

Query: 345 DPVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSE 402
            P+    +EY+  S  G +     +    Y +  L P++EYEI V  +     G G P  
Sbjct: 321 GPIILKEVEYRMTS--GSWTETHAVNAPTYKLWHLDPDTEYEIRVLLTRPGEGGTGLPGP 378

Query: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRV--YYTMEPEHPVG 460
            ++TRT    P   P+ ++   + A  + V WE          GY +   +T        
Sbjct: 379 PLITRTKCAEPMRTPKTLKIAEIQARRIAVDWES--------LGYNITRCHTFNVTICYH 430

Query: 461 NWQKHN--------VDDSLLTTVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVP 512
            ++ HN        +D      V + L   T     +  T+      S+   ++T + VP
Sbjct: 431 YFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLKMILTNPEGRKESEETIIQTDEDVP 490

Query: 513 GQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP------- 562
           G  P+        E  I L+W  P   +  I +YE+ +          R+FDP       
Sbjct: 491 GPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSS-------IRSFDPAVPVAGP 543

Query: 563 ---------TTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVK 613
                    +T +V   L P T Y F + A + +G G  T  +   T  S P+ P  +  
Sbjct: 544 PQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPAT-AINVTTNISAPTLPDYEGV 602

Query: 614 CVSVRSTAILVSWRPPPPETHNGALVGYSV 643
             S+  TA  ++    P +     +  Y +
Sbjct: 603 DASLNETATTITVLLRPAQAKGAPISAYQI 632



 Score = 46.2 bits (108), Expect = 3e-04
 Identities = 53/248 (21%), Positives = 96/248 (38%), Gaps = 20/248 (8%)

Query: 320 KAPGTPMVTENTATSITITWDSGNPDPVSYYVIE-------YKSKSQDGPYQIKEDITTT 372
           + P T  + E  A  I + W+S   +    +          ++  ++     +  D    
Sbjct: 391 RTPKTLKIAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAP 450

Query: 373 RYSIGGLSPNSEYEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIV 432
           ++ +  L P +   + +   N  G+   SE  + +T E  P   P            + +
Sbjct: 451 QHVVNHLPPYTNVSLKMILTNPEGR-KESEETIIQTDEDVPGPVPVKSLQGTSFENKIFL 509

Query: 433 QWEEPVEPNGLIRGYRVYY----TMEPEHPVGNWQK--HNVDDSLLTTVGSLLEDETYTV 486
            W+EP++PNG+I  Y + Y    + +P  PV    +   N+ +S       L    TY  
Sbjct: 510 NWKEPLDPNGIITQYEISYSSIRSFDPAVPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQF 569

Query: 487 RVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA---RSETSITLSWSPPRQES--II 541
            + A T  G GP +  I V T    P  P     +A    + T+IT+   P + +   I 
Sbjct: 570 FIRASTVKGFGP-ATAINVTTNISAPTLPDYEGVDASLNETATTITVLLRPAQAKGAPIS 628

Query: 542 KYELLFRE 549
            Y+++  E
Sbjct: 629 AYQIVVEE 636



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 101/420 (24%), Positives = 157/420 (37%), Gaps = 55/420 (13%)

Query: 565 SYVVEDLKPNTEYAFRLAARSPQGLGAFT---PVVRQRTLQSKPSAPPQDVKCVSVRSTA 621
           S+ ++++    +  +R   +S +G G       +VR+     +P APPQ    + V  T 
Sbjct: 254 SFRLQEVTKTDQDLYRCVTQSERGSGVSNFAQLIVRE---PPRPIAPPQ---LLGVGPTY 307

Query: 622 ILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKWTQY-- 679
           +L+          +G ++   V YR       E   VN   PT     L  L+  T+Y  
Sbjct: 308 LLIQLNANSI-IGDGPIILKEVEYRMTSGSWTETHAVNA--PTYK---LWHLDPDTEYEI 361

Query: 680 RITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQ 739
           R+      E G G    P++ RT    P   P+ ++   + A  I V W S         
Sbjct: 362 RVLLTRPGEGGTGLPGPPLITRTKCAEPMRTPKTLKIAEIQARRIAVDWESLGYNITRCH 421

Query: 740 IRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARS 799
                + Y    G        +   M   A + V+ +L P T  S+ +     +G    S
Sbjct: 422 TFNVTICYHYFRGHNESKADCLD--MDPKAPQHVVNHLPPYTNVSLKMILTNPEG-RKES 478

Query: 800 KPKVVVTKGAVLGR-PTLSVQQTP-EGSLLARW-EP--PAGTAEDQVLGYRLQFGREDST 854
           +  ++ T   V G  P  S+Q T  E  +   W EP  P G      + Y      + + 
Sbjct: 479 EETIIQTDEDVPGPVPVKSLQGTSFENKIFLNWKEPLDPNGIITQYEISYSSIRSFDPAV 538

Query: 855 PLA----TLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRGHP 910
           P+A    T+    +   +    +H G TY F + A +  G G   A    I   T    P
Sbjct: 539 PVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPATA----INVTTNISAP 594

Query: 911 QILEAAG-------NASAGTVLLRWLPPVPAERNGA-IVKYTVAV---------REAGAL 953
            + +  G        A+  TVLLR     PA+  GA I  Y + V         REAGA+
Sbjct: 595 TLPDYEGVDASLNETATTITVLLR-----PAQAKGAPISAYQIVVEELHPHRTKREAGAM 649



 Score = 45.4 bits (106), Expect = 5e-04
 Identities = 50/242 (20%), Positives = 86/242 (35%), Gaps = 31/242 (12%)

Query: 776 NLQPETAYSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAG 835
           +L P+T Y I V   T  G+G    P   +        P     +TP+   +A  +    
Sbjct: 352 HLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEP----MRTPKTLKIAEIQARRI 406

Query: 836 TAEDQVLGYRLQ-------------FGREDSTPLATLEFPPSEDRYTASGVHKGATYVFR 882
             + + LGY +              F   + +    L+  P   ++  + +        +
Sbjct: 407 AVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHLPPYTNVSLK 466

Query: 883 LAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVK 942
           +   +  G  E    ++   ED P G   +    G +    + L W  P+  + NG I +
Sbjct: 467 MILTNPEGRKESEETIIQTDEDVP-GPVPVKSLQGTSFENKIFLNWKEPL--DPNGIITQ 523

Query: 943 YTVAVREAGALGPARETELPAAAEPGAENAL------TLQGLKPDTAYDLQVRAHTRRGP 996
           Y ++     +  PA    +P A  P   + L          L P T Y   +RA T +G 
Sbjct: 524 YEISYSSIRSFDPA----VPVAGPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGF 579

Query: 997 GP 998
           GP
Sbjct: 580 GP 581



 Score = 34.3 bits (77), Expect = 1.2
 Identities = 38/134 (28%), Positives = 57/134 (42%), Gaps = 21/134 (15%)

Query: 966  EPGAENALT--LQGLKPDTAYDLQVRAHTRRGPGPFS---PPVRYRTFLRDQV-SPKNFK 1019
            E  A NA T  L  L PDT Y+++V   TR G G      PP+  RT   + + +PK  K
Sbjct: 339  ETHAVNAPTYKLWHLDPDTEYEIRVLL-TRPGEGGTGLPGPPLITRTKCAEPMRTPKTLK 397

Query: 1020 VKMIMKTSVLLSWEFPD-------NYNSPTPYKI-----QYNGLTLDVDGRTTKKLITHL 1067
            +  I    + + WE           +N    Y       +     LD+D +  + ++ HL
Sbjct: 398  IAEIQARRIAVDWESLGYNITRCHTFNVTICYHYFRGHNESKADCLDMDPKAPQHVVNHL 457

Query: 1068 KPHT--FYNFVLTN 1079
             P+T      +LTN
Sbjct: 458  PPYTNVSLKMILTN 471



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 30/122 (24%), Positives = 57/122 (46%), Gaps = 7/122 (5%)

Query: 30  EEPPRFIKEPKDQIGVSGGVASFVCQATG-DPKPRVTW--NKKGKKVNSQRFETIEFDES 86
           ++ P F++    ++  +G  A+F C ATG D      W   + G+ +   + + I     
Sbjct: 193 DKSPHFLRLGDVEVN-AGQNATFQCIATGRDAVHNKLWLQRRNGEDIPVAQTKNINHRRF 251

Query: 87  AGAVLRIQPLRTPRDENVYECVAQNSVGEITVHAKLTVLREDQLPSGFPN-IDMGPQLKV 145
           A A  R+Q + T  D+++Y CV Q+  G    +    ++RE   P   P  + +GP   +
Sbjct: 252 A-ASFRLQEV-TKTDQDLYRCVTQSERGSGVSNFAQLIVREPPRPIAPPQLLGVGPTYLL 309

Query: 146 VE 147
           ++
Sbjct: 310 IQ 311


>gi|157419150 protein tyrosine phosphatase, receptor type, M isoform 2
            precursor [Homo sapiens]
          Length = 1452

 Score =  498 bits (1283), Expect = e-140
 Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)

Query: 1304 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 1363
            + + L   H     E   + +QT G L HP I +AD+ +H  ++K  +     +EYES  
Sbjct: 851  DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 908

Query: 1364 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1423
             GQ   W+ +  + N+ KNRY N+IAYDHSRV LQ IEG   SDYIN NY+DGY   N Y
Sbjct: 909  EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 968

Query: 1424 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1483
            IATQGP+ ET  DFWRMVW + +A+I+M+T L E  R+KC +YWP+  TE Y  I+VTL+
Sbjct: 969  IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1027

Query: 1484 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1543
            +T  LA + +RTF++ K G  E RE+RQF FT WPDHGVP + T  L F+R+VK+ +PP 
Sbjct: 1028 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1087

Query: 1544 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1603
            AGP+VVHCSAG GRTGCFIVID ML+  + E  VD+Y  V  +RS+R  MVQTE+QY FI
Sbjct: 1088 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1147

Query: 1604 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1661
            H+A+LEA  CG+T VPA  + +    + +++P  + + ++ EF+ L N    T R     
Sbjct: 1148 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1206

Query: 1662 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720
             A LP N  KNR ++I+P +     L  I G E S+YINA+ +D Y+Q  A+I TQ PL 
Sbjct: 1207 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1265

Query: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1777
             T +DFWR++ + + T VVML  +     + C QYWP     R    Q   V    E ++
Sbjct: 1266 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1323

Query: 1778 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1835
               I R +     +DG  R V+QFQF  WP  +  P S   F+  I QV K +E++ G +
Sbjct: 1324 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1382

Query: 1836 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1895
            G   VHC  G GR+G F  +SIV E +R++  VD+F  VK LR  +P MV   D+Y+FCY
Sbjct: 1383 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1442

Query: 1896 QAALEYLGS 1904
            + ALEYL S
Sbjct: 1443 EVALEYLNS 1451



 Score =  133 bits (334), Expect = 2e-30
 Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1378 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1437
            N  KNR  +++  D     L  I+G   S+YINA  +D Y+  +A+I TQ PLP T  DF
Sbjct: 1213 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1271

Query: 1438 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1497
            WR+V +    ++VM+  ++      C QYWP  G   +G IQV  +          R F 
Sbjct: 1272 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1329

Query: 1498 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1551
            ++     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1330 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1389

Query: 1552 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1611
              G GR+G F  I  + E ++ ++TVDV+  V  +R+ +  MV   DQY F +E  LE +
Sbjct: 1390 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1449

Query: 1612 GCG 1614
              G
Sbjct: 1450 NSG 1452



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 100/408 (24%), Positives = 172/408 (42%), Gaps = 44/408 (10%)

Query: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 291
           E+  G      C A+G  +   + W+QG +          +T         NV+  T  +
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253

Query: 292 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 347
           D+  Y C+  +  GV I   A++ VK  P     P +    AT + I  ++ + +   P+
Sbjct: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313

Query: 348 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 405
               +EY + S  G +  ++ + +T Y IG L P++EYEI V  +     G G P  ++ 
Sbjct: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371

Query: 406 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 465
           TRT    P   PR ++   + +  + ++W EP   N + R +    T+   + VG  ++ 
Sbjct: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429

Query: 466 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 517
             + S  T       T+ +L      +V+++     G    S  + V+T + +PG  P  
Sbjct: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488

Query: 518 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 566
               +  E  I L W  P Q    I  YE+ ++       E D   + GR       T +
Sbjct: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548

Query: 567 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ-SKPSAPPQDVK 613
           +   L P T Y+F + A + +G G   P   Q T + S PS P  +++
Sbjct: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAPSMPAYELE 594



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 64/245 (26%), Positives = 104/245 (42%), Gaps = 18/245 (7%)

Query: 563 TTSYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRST 620
           +TSY +  L P+TEY   +    P   G G+  P +R RT  + P   P+ ++ V V+S 
Sbjct: 335 STSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSR 394

Query: 621 AILVSWRPPPPETHNGALVGYSVRY-RPLGSEDPEPKEVN-GIPPTTTQILLEALEKWTQ 678
            I + W P             +V Y   +G ++   +EV+     +  Q  +  L  +T 
Sbjct: 395 QITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTN 454

Query: 679 YRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 738
             +  +     G   ES  ++V+TDED+P A P +    +     I + WR P   + +G
Sbjct: 455 VSVKLILMNPEG-RKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYG 511

Query: 739 QIRGYQVHYVRMEGAEARGPPRI-------KDVMLADAQEMVITNLQPETAYSITVAAYT 791
            I  Y++ Y  +   +    P I       +   L +    +   L P T YS T+ A T
Sbjct: 512 VITLYEITYKAVSSFD----PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRAST 567

Query: 792 MKGDG 796
            KG G
Sbjct: 568 AKGFG 572



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 78/332 (23%), Positives = 119/332 (35%), Gaps = 42/332 (12%)

Query: 687 TEVGPGPESSPVVVRTDEDVPSAPPRKVEAEA------LNATAIRVLWRSPAPGRQHGQI 740
           TE G G  +   +V  +  VP APP+     A      LNA +I             G I
Sbjct: 264 TEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSIN----------GDGPI 313

Query: 741 RGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSK 800
              +V Y    G+     P        D+    I +L P+T Y I+V   T  G+G    
Sbjct: 314 VAREVEYCTASGSWNDRQP-------VDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGS 365

Query: 801 PKVVV---TKGA--VLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF------- 848
           P   +   TK A  + G   L V +     +  RWEP  G    +   Y L         
Sbjct: 366 PGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEP-FGYNVTRCHSYNLTVHYCYQVG 424

Query: 849 GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRG 908
           G+E      + +   S  ++T + +        +L   +  G  E    ++   ED P  
Sbjct: 425 GQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGA 484

Query: 909 HPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARE--TELPAAAE 966
            P      G+     + L+W  P   +  G I  Y +  +   +  P  +   +    ++
Sbjct: 485 VPTE-SIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSK 541

Query: 967 PGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 998
            G E      GL P T Y   +RA T +G GP
Sbjct: 542 LGNETHFLFFGLYPGTTYSFTIRASTAKGFGP 573



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 77/321 (23%), Positives = 121/321 (37%), Gaps = 34/321 (10%)

Query: 662 PPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSP---VVVRTDEDVPSAPPRKVEAEA 718
           P  +T   +  L+  T+Y I+ +  T  G G   SP   +  RT    P   PRK+E   
Sbjct: 332 PVDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVE 390

Query: 719 LNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ----EMVI 774
           + +  I + W                VHY    G    G  ++++ +  D +    +  I
Sbjct: 391 VKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG----GQEQVREEVSWDTENSHPQHTI 446

Query: 775 TNLQPETAYSITVAAYTMKGDGARSKPKVVVTK-----GAVLGRPTLSVQ-QTPEGSLLA 828
           TNL P T  +++V    M  +G +   +++V       GAV   PT S+Q  T E  +  
Sbjct: 447 TNLSPYT--NVSVKLILMNPEGRKESQELIVQTDEDLPGAV---PTESIQGSTFEEKIFL 501

Query: 829 RWEPPA---GTAEDQVLGYRLQFGREDSTPLATLEFPPS----EDRYTASGVHKGATYVF 881
           +W  P    G      + Y+     +    L+      S    E  +   G++ G TY F
Sbjct: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561

Query: 882 RLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIV 941
            + A +  G G  A    +     P      LE   N +  TV +      PA   GA V
Sbjct: 562 TIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML---KPAHSRGAPV 618

Query: 942 K-YTVAVREAGALGPARETEL 961
             Y + V E       + TE+
Sbjct: 619 SVYQIVVEEERPRRTKKTTEI 639



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 73/305 (23%), Positives = 111/305 (36%), Gaps = 54/305 (17%)

Query: 1028 VLLSWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTF 1072
            + L W  P   Y   T Y+I Y  ++    ++D           G  T  L   L P T 
Sbjct: 499  IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558

Query: 1073 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP 1126
            Y+F +  R S+  G     T    F      PS+       P    D  + V L    S 
Sbjct: 559  YSFTI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614

Query: 1127 -VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 1185
              PV  Y IV+   R  R         + +  ++ +        Q  SL +S+       
Sbjct: 615  GAPVSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------ 659

Query: 1186 YIAARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------F 1235
            Y AA F          F  GD K Y G+ N  L P   Y ++  A  + +  T       
Sbjct: 660  YFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQV 719

Query: 1236 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1295
            A    + P  +  P+P+   D    +  VI  +L  V II + + +++ K K   KRK++
Sbjct: 720  ATKGAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKET 776

Query: 1296 EPRTK 1300
               T+
Sbjct: 777  MSSTR 781


>gi|157419152 protein tyrosine phosphatase, receptor type, M isoform 1
            precursor [Homo sapiens]
          Length = 1465

 Score =  498 bits (1283), Expect = e-140
 Identities = 276/609 (45%), Positives = 373/609 (61%), Gaps = 16/609 (2%)

Query: 1304 NNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESID 1363
            + + L   H     E   + +QT G L HP I +AD+ +H  ++K  +     +EYES  
Sbjct: 864  DTSSLVQSHTYKKREPADVPYQT-GQL-HPAIRVADLLQHITQMKCAEGYGFKEEYESFF 921

Query: 1364 PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAY 1423
             GQ   W+ +  + N+ KNRY N+IAYDHSRV LQ IEG   SDYIN NY+DGY   N Y
Sbjct: 922  EGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHY 981

Query: 1424 IATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLL 1483
            IATQGP+ ET  DFWRMVW + +A+I+M+T L E  R+KC +YWP+  TE Y  I+VTL+
Sbjct: 982  IATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPD-DTEIYKDIKVTLI 1040

Query: 1484 DTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPD 1543
            +T  LA + +RTF++ K G  E RE+RQF FT WPDHGVP + T  L F+R+VK+ +PP 
Sbjct: 1041 ETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPS 1100

Query: 1544 AGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFI 1603
            AGP+VVHCSAG GRTGCFIVID ML+  + E  VD+Y  V  +RS+R  MVQTE+QY FI
Sbjct: 1101 AGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFI 1160

Query: 1604 HEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFIS-- 1661
            H+A+LEA  CG+T VPA  + +    + +++P  + + ++ EF+ L N    T R     
Sbjct: 1161 HDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTL-NMVTPTLRVEDCS 1219

Query: 1662 -ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLA 1720
             A LP N  KNR ++I+P +     L  I G E S+YINA+ +D Y+Q  A+I TQ PL 
Sbjct: 1220 IALLPRNHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLP 1278

Query: 1721 ETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWP---AERSARYQYFVVDPMAEYNM 1777
             T +DFWR++ + + T VVML  +     + C QYWP     R    Q   V    E ++
Sbjct: 1279 NTVKDFWRLVLDYHCTSVVMLNDVDP--AQLCPQYWPENGVHRHGPIQVEFVSADLEEDI 1336

Query: 1778 PQYILREFKVTDARDGQSRTVRQFQFTDWP-EQGVPKSGEGFIDFIGQVHKTKEQF-GQD 1835
               I R +     +DG  R V+QFQF  WP  +  P S   F+  I QV K +E++ G +
Sbjct: 1337 ISRIFRIYNAARPQDGY-RMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGE 1395

Query: 1836 GPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1895
            G   VHC  G GR+G F  +SIV E +R++  VD+F  VK LR  +P MV   D+Y+FCY
Sbjct: 1396 GRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCY 1455

Query: 1896 QAALEYLGS 1904
            + ALEYL S
Sbjct: 1456 EVALEYLNS 1464



 Score =  133 bits (334), Expect = 2e-30
 Identities = 83/243 (34%), Positives = 120/243 (49%), Gaps = 9/243 (3%)

Query: 1378 NKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDF 1437
            N  KNR  +++  D     L  I+G   S+YINA  +D Y+  +A+I TQ PLP T  DF
Sbjct: 1226 NHEKNRCMDILPPDRCLPFLITIDG-ESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDF 1284

Query: 1438 WRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFS 1497
            WR+V +    ++VM+  ++      C QYWP  G   +G IQV  +          R F 
Sbjct: 1285 WRLVLDYHCTSVVMLNDVDPAQL--CPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFR 1342

Query: 1498 LHKNGSSEK--REVRQFQFTAWPDH-GVPEYPTPFLAFLRRVKTCNPP---DAGPIVVHC 1551
            ++     +   R V+QFQF  WP +   P     FL  +R+V           G  VVHC
Sbjct: 1343 IYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHC 1402

Query: 1552 SAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAV 1611
              G GR+G F  I  + E ++ ++TVDV+  V  +R+ +  MV   DQY F +E  LE +
Sbjct: 1403 LNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYL 1462

Query: 1612 GCG 1614
              G
Sbjct: 1463 NSG 1465



 Score = 79.3 bits (194), Expect = 3e-14
 Identities = 100/408 (24%), Positives = 172/408 (42%), Gaps = 44/408 (10%)

Query: 242 EIMPGGNVNITCVAVGSPMPYVK-WMQGAE---------DLTPEDDMPVGRNVLELTDVK 291
           E+  G      C A+G  +   + W+QG +          +T         NV+  T  +
Sbjct: 195 EVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTK-R 253

Query: 292 DSANYTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGNPD---PV 347
           D+  Y C+  +  GV I   A++ VK  P     P +    AT + I  ++ + +   P+
Sbjct: 254 DAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPI 313

Query: 348 SYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVV 405
               +EY + S  G +  ++ + +T Y IG L P++EYEI V  +     G G P  ++ 
Sbjct: 314 VAREVEYCTAS--GSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALR 371

Query: 406 TRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKH 465
           TRT    P   PR ++   + +  + ++W EP   N + R +    T+   + VG  ++ 
Sbjct: 372 TRTKCADPMRGPRKLEVVEVKSRQITIRW-EPFGYN-VTRCHSYNLTVHYCYQVGGQEQV 429

Query: 466 NVDDSLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQ-PMN 517
             + S  T       T+ +L      +V+++     G    S  + V+T + +PG  P  
Sbjct: 430 REEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKE-SQELIVQTDEDLPGAVPTE 488

Query: 518 LRAEARSETSITLSWSPPRQE--SIIKYELLFR-------EGDHGREVGRT--FDPTTSY 566
               +  E  I L W  P Q    I  YE+ ++       E D   + GR       T +
Sbjct: 489 SIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHF 548

Query: 567 VVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQ-SKPSAPPQDVK 613
           +   L P T Y+F + A + +G G   P   Q T + S PS P  +++
Sbjct: 549 LFFGLYPGTTYSFTIRASTAKGFG--PPATNQFTTKISAPSMPAYELE 594



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 64/245 (26%), Positives = 104/245 (42%), Gaps = 18/245 (7%)

Query: 563 TTSYVVEDLKPNTEYAFRLAARSPQ--GLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRST 620
           +TSY +  L P+TEY   +    P   G G+  P +R RT  + P   P+ ++ V V+S 
Sbjct: 335 STSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSR 394

Query: 621 AILVSWRPPPPETHNGALVGYSVRY-RPLGSEDPEPKEVN-GIPPTTTQILLEALEKWTQ 678
            I + W P             +V Y   +G ++   +EV+     +  Q  +  L  +T 
Sbjct: 395 QITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTN 454

Query: 679 YRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGRQHG 738
             +  +     G   ES  ++V+TDED+P A P +    +     I + WR P   + +G
Sbjct: 455 VSVKLILMNPEG-RKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPT--QTYG 511

Query: 739 QIRGYQVHYVRMEGAEARGPPRI-------KDVMLADAQEMVITNLQPETAYSITVAAYT 791
            I  Y++ Y  +   +    P I       +   L +    +   L P T YS T+ A T
Sbjct: 512 VITLYEITYKAVSSFD----PEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRAST 567

Query: 792 MKGDG 796
            KG G
Sbjct: 568 AKGFG 572



 Score = 57.0 bits (136), Expect = 2e-07
 Identities = 78/332 (23%), Positives = 119/332 (35%), Gaps = 42/332 (12%)

Query: 687 TEVGPGPESSPVVVRTDEDVPSAPPRKVEAEA------LNATAIRVLWRSPAPGRQHGQI 740
           TE G G  +   +V  +  VP APP+     A      LNA +I             G I
Sbjct: 264 TEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSIN----------GDGPI 313

Query: 741 RGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSK 800
              +V Y    G+     P        D+    I +L P+T Y I+V   T  G+G    
Sbjct: 314 VAREVEYCTASGSWNDRQP-------VDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGS 365

Query: 801 PKVVV---TKGA--VLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF------- 848
           P   +   TK A  + G   L V +     +  RWEP  G    +   Y L         
Sbjct: 366 PGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEP-FGYNVTRCHSYNLTVHYCYQVG 424

Query: 849 GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDTPRG 908
           G+E      + +   S  ++T + +        +L   +  G  E    ++   ED P  
Sbjct: 425 GQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGA 484

Query: 909 HPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALGPARE--TELPAAAE 966
            P      G+     + L+W  P   +  G I  Y +  +   +  P  +   +    ++
Sbjct: 485 VPTE-SIQGSTFEEKIFLQWREPT--QTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSK 541

Query: 967 PGAENALTLQGLKPDTAYDLQVRAHTRRGPGP 998
            G E      GL P T Y   +RA T +G GP
Sbjct: 542 LGNETHFLFFGLYPGTTYSFTIRASTAKGFGP 573



 Score = 53.9 bits (128), Expect = 1e-06
 Identities = 77/321 (23%), Positives = 121/321 (37%), Gaps = 34/321 (10%)

Query: 662 PPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSP---VVVRTDEDVPSAPPRKVEAEA 718
           P  +T   +  L+  T+Y I+ +  T  G G   SP   +  RT    P   PRK+E   
Sbjct: 332 PVDSTSYKIGHLDPDTEYEISVLL-TRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVE 390

Query: 719 LNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQ----EMVI 774
           + +  I + W                VHY    G    G  ++++ +  D +    +  I
Sbjct: 391 VKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVG----GQEQVREEVSWDTENSHPQHTI 446

Query: 775 TNLQPETAYSITVAAYTMKGDGARSKPKVVVTK-----GAVLGRPTLSVQ-QTPEGSLLA 828
           TNL P T  +++V    M  +G +   +++V       GAV   PT S+Q  T E  +  
Sbjct: 447 TNLSPYT--NVSVKLILMNPEGRKESQELIVQTDEDLPGAV---PTESIQGSTFEEKIFL 501

Query: 829 RWEPPA---GTAEDQVLGYRLQFGREDSTPLATLEFPPS----EDRYTASGVHKGATYVF 881
           +W  P    G      + Y+     +    L+      S    E  +   G++ G TY F
Sbjct: 502 QWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSF 561

Query: 882 RLAARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIV 941
            + A +  G G  A    +     P      LE   N +  TV +      PA   GA V
Sbjct: 562 TIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVML---KPAHSRGAPV 618

Query: 942 K-YTVAVREAGALGPARETEL 961
             Y + V E       + TE+
Sbjct: 619 SVYQIVVEEERPRRTKKTTEI 639



 Score = 38.5 bits (88), Expect = 0.063
 Identities = 73/305 (23%), Positives = 111/305 (36%), Gaps = 54/305 (17%)

Query: 1028 VLLSWEFP-DNYNSPTPYKIQYNGLTL---DVD-----------GRTTKKLITHLKPHTF 1072
            + L W  P   Y   T Y+I Y  ++    ++D           G  T  L   L P T 
Sbjct: 499  IFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTT 558

Query: 1073 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQSP 1126
            Y+F +  R S+  G     T    F      PS+       P    D  + V L    S 
Sbjct: 559  YSFTI--RASTAKGFGPPAT--NQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSR 614

Query: 1127 -VPVQSYFIVMVPLRKSRGGQFLTPLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRP 1185
              PV  Y IV+   R  R         + +  ++ +        Q  SL +S+       
Sbjct: 615  GAPVSVYQIVVEEERPRR---------TKKTTEILKCYPVPIHFQNASLLNSQY------ 659

Query: 1186 YIAARFSV----LPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPT------F 1235
            Y AA F          F  GD K Y G+ N  L P   Y ++  A  + +  T       
Sbjct: 660  YFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQV 719

Query: 1236 AASPFSDPFQLDNPDPQPIVDGEEGLIWVIGPVLAVVFIICIVIAILLYKNKPDSKRKDS 1295
            A    + P  +  P+P+   D    +  VI  +L  V II + + +++ K K   KRK++
Sbjct: 720  ATKGAATPKPV--PEPEKQTDHTVKIAGVIAGILLFV-IIFLGVVLVMKKRKLAKKRKET 776

Query: 1296 EPRTK 1300
               T+
Sbjct: 777  MSSTR 781


>gi|148539860 protein tyrosine phosphatase, receptor type, T isoform 2
            precursor [Homo sapiens]
          Length = 1441

 Score =  480 bits (1236), Expect = e-135
 Identities = 323/973 (33%), Positives = 490/973 (50%), Gaps = 128/973 (13%)

Query: 1028 VLLSWEFPDNYNSP-TPYKIQYNGL-TLDVDG-------------RTTKKLITHLKPHTF 1072
            + + W+ P+  N   T Y+I Y  + +LD                  T  L   L P T 
Sbjct: 502  IYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTT 561

Query: 1073 YNFVLTNRGSSLGGLQQTVTAWTAFNLLNGKPSV------APKPDADGFIMVYLPDGQS- 1125
            Y+F +  + S+  G    VT   A  +    PS+       P  + D  I V L   QS 
Sbjct: 562  YSFTI--KASTAKGFGPPVTTRIATKI--SAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617

Query: 1126 --PVPVQSYFIVMVPLRKSRGGQ-----FLTPLGSPEDMDLEELIQDISRLQRRSLRHSR 1178
              PV V    +    L+KSR        F  P+       L+ L    + L+  +L    
Sbjct: 618  GAPVSVYQLVVKEERLQKSRRAADIIECFSVPVSYRNASSLDSLHYFAAELKPANL---- 673

Query: 1179 QLEVPRPYIAARFSVLPPTFHPGDQKQYGGFDNRGLEPGHRYVLFVLAVLQKSEPTFA-- 1236
               V +P+              GD K Y G+ N  L P   Y ++  A+ + +  T    
Sbjct: 674  --PVTQPFTV------------GDNKTYNGYWNPPLSPLKSYSIYFQALSKANGETKINC 719

Query: 1237 ---ASPFSDPFQLDNPDPQPIVDGEEGLIWVI-GPVLAVVFIICIVIAILLYKN------ 1286
               A+  +     +  +P+  VD    +  VI G ++ ++ ++ +++ I   +N      
Sbjct: 720  VRLATKGASTQNSNTVEPEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAYSYSY 779

Query: 1287 --KPDSKRKDSE---------------PRTKCLLNNADLA-------------------- 1309
              K   K+K+++               P TK   +  D                      
Sbjct: 780  YLKLAKKQKETQSGAQREMGPVASADKPTTKLSASRNDEGFSSSSQDVNGFTDGSRGELS 839

Query: 1310 ---------PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQE 1358
                     P+   DPVEM   R  FQ       P I +AD+ +H  ++K        +E
Sbjct: 840  QPTLTIQTHPYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEE 892

Query: 1359 YESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYR 1418
            YE++  GQ  +W+ +  + N+ KNRY N+I+YDHSRV L  ++G   SDYINANY+DGY 
Sbjct: 893  YEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYH 952

Query: 1419 CQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFI 1478
                YIATQGP+ ET  DFWRM+W++ SA+IVM+T L E  R+KC +YWP+  TE YG I
Sbjct: 953  RPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDI 1011

Query: 1479 QVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKT 1538
            +VTL++T  LA + +RTF++ K G  E RE+R F FT+WPDHGVP Y T  L F+R+VK 
Sbjct: 1012 KVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKF 1071

Query: 1539 CNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTED 1598
             NPP+AGPIVVHCSAG GRTGCFI ID ML+  + E  VD++  V  +R+QR  +VQTE+
Sbjct: 1072 LNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEE 1131

Query: 1599 QYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHT 1656
            QY F+H+A+LEA  CGNT +P     +    +++++P  + + ++ EF+ L     +   
Sbjct: 1132 QYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRP 1191

Query: 1657 SRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQ 1716
                   LP N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ
Sbjct: 1192 EDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQ 1250

Query: 1717 GPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN 1776
             PL  T  DFWR++++ N + VVML ++     + C QYWP + S  Y    V+ ++   
Sbjct: 1251 HPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADI 1308

Query: 1777 MPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF- 1832
                I R F++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +EQ+ 
Sbjct: 1309 DEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYD 1368

Query: 1833 GQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQ 1892
            G++G   VHC  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T ++Y+
Sbjct: 1369 GREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYK 1428

Query: 1893 FCYQAALEYLGSF 1905
            F Y+ ALEYL SF
Sbjct: 1429 FVYEVALEYLSSF 1441



 Score = 87.8 bits (216), Expect = 9e-17
 Identities = 114/437 (26%), Positives = 182/437 (41%), Gaps = 50/437 (11%)

Query: 229 RVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPEDDMPVGRNV 284
           R AP F  L  + E+  G N    C+A G    + K W+Q   G +       +   R  
Sbjct: 190 RKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRF 248

Query: 285 LELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITIT 338
                V D+A      Y CV  S  G  +   A++ VK  P     P   E  A   T  
Sbjct: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL 305

Query: 339 WDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--S 390
           W   N +      P+    +EY++ +  G +     + +  Y +  L P+ EYEI V  +
Sbjct: 306 WIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVEYEIRVLLT 363

Query: 391 AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG--LIRGYR 448
                G GPP   + TRT    P   P+NV+   + A  + +QW    EP G  + R + 
Sbjct: 364 RPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHS 419

Query: 449 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGPL-SDPIQV 505
              T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G + S+ + V
Sbjct: 420 YNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478

Query: 506 KTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR-------EGDHGRE 555
           +T++ VPG  P+        E  I + W PP + +  I  YE+ ++         D   +
Sbjct: 479 QTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQ 538

Query: 556 VGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV-VRQRTLQSKPSAPPQDV 612
            G+ F     T ++   L P T Y+F + A + +G G   PV  R  T  S PS P  D 
Sbjct: 539 RGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG--PPVTTRIATKISAPSMPEYDT 596

Query: 613 KC-VSVRSTAILVSWRP 628
              ++   T I V  +P
Sbjct: 597 DTPLNETDTTITVMLKP 613



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 83/351 (23%), Positives = 124/351 (35%), Gaps = 26/351 (7%)

Query: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 462
           S V+   E      P  +    L A      W +P   + +  G  +   +E     G W
Sbjct: 275 SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334

Query: 463 QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 519
            + ++ DS    +  L  D  Y +RVL       G GP   P+  +T+   P   P N+ 
Sbjct: 335 AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394

Query: 520 AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 571
                   +TL W P              ++Y+ +F +  +  E       ++ Y +  L
Sbjct: 395 IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452

Query: 572 KPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPP 631
           +P      RL   +P+G      +V Q T +  P A P +          I + W+PP  
Sbjct: 453 RPFMTIRLRLLLSNPEGRMESEELVVQ-TEEDVPGAVPLESIQGGPFEEKIYIQWKPPN- 510

Query: 632 ETHNGALVGYSVRYRPLGSEDPEPKEVNGIPP-----TTTQILLEALEKWTQYRITTVAH 686
           ET NG +  Y + Y+ +GS DP     +           T  L   L   T Y  T  A 
Sbjct: 511 ET-NGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKAS 569

Query: 687 TEVGPGPESSPVVVR--TDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 735
           T  G GP   PV  R  T    PS P    +           +   PA  R
Sbjct: 570 TAKGFGP---PVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 86/354 (24%), Positives = 128/354 (36%), Gaps = 35/354 (9%)

Query: 665  TTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAI 724
            T  +   A    ++YR   V  ++ G G  +   ++  +   P APP   E  A+ AT  
Sbjct: 251  TVSVADTAQRSVSKYRC--VIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGAT-- 303

Query: 725  RVLWRSPAPGR--QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETA 782
              LW  P        G I   +V Y    G  A       +  + D+    + +L P+  
Sbjct: 304  -YLWIKPNANSIIGDGPIILKEVEYRTTTGTWA-------ETHIVDSPNYKLWHLDPDVE 355

Query: 783  YSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLAR-----WEPPAGTA 837
            Y I V   T  G+G    P   +T       P    Q      + AR     WEP  G A
Sbjct: 356  YEIRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP-FGYA 413

Query: 838  EDQVLGYRLQFGRE---DSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE 894
              +   Y L    +   +       E   +   YT  G+    T   RL   +  G  E 
Sbjct: 414  VTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473

Query: 895  AAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALG 954
               V+   ED P   P +    G      + ++W PP   E NG I  Y +  +  G+L 
Sbjct: 474  EELVVQTEEDVPGAVP-LESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLD 530

Query: 955  PARE--TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYR 1006
            P+ +  ++     +   E      GL P T Y   ++A T +G   F PPV  R
Sbjct: 531  PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKG---FGPPVTTR 581


>gi|148539858 protein tyrosine phosphatase, receptor type, T isoform 1
            precursor [Homo sapiens]
          Length = 1460

 Score =  473 bits (1217), Expect = e-133
 Identities = 251/604 (41%), Positives = 368/604 (60%), Gaps = 19/604 (3%)

Query: 1310 PHHPKDPVEMR--RINFQTPGMLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQ 1367
            P+   DPVEM   R  FQ       P I +AD+ +H  ++K        +EYE++  GQ 
Sbjct: 868  PYRTCDPVEMSYPRDQFQ-------PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQT 920

Query: 1368 FTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQ 1427
             +W+ +  + N+ KNRY N+I+YDHSRV L  ++G   SDYINANY+DGY     YIATQ
Sbjct: 921  ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQ 980

Query: 1428 GPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIE 1487
            GP+ ET  DFWRM+W++ SA+IVM+T L E  R+KC +YWP+  TE YG I+VTL++T  
Sbjct: 981  GPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEP 1039

Query: 1488 LATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPI 1547
            LA + +RTF++ K G  E RE+R F FT+WPDHGVP Y T  L F+R+VK  NPP+AGPI
Sbjct: 1040 LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPI 1099

Query: 1548 VVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEAL 1607
            VVHCSAG GRTGCFI ID ML+  + E  VD++  V  +R+QR  +VQTE+QY F+H+A+
Sbjct: 1100 VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI 1159

Query: 1608 LEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLP 1665
            LEA  CGNT +P     +    +++++P  + + ++ EF+ L     +          LP
Sbjct: 1160 LEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLP 1219

Query: 1666 CNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1725
             N  KNR ++++P +     L  + G E S+YINA+ +D ++Q  A++ TQ PL  T  D
Sbjct: 1220 RNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVAD 1278

Query: 1726 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1785
            FWR++++ N + VVML ++     + C QYWP + S  Y    V+ ++       I R F
Sbjct: 1279 FWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIF 1336

Query: 1786 KVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFIDFIGQVHKTKEQF-GQDGPISVH 1841
            ++ +    Q   R V+  Q+  WP  +  P S    +  + ++ K +EQ+ G++G   VH
Sbjct: 1337 RICNMARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVH 1396

Query: 1842 CSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEY 1901
            C  G GR+G F  +  V E ++ + ++D+F  VK LR  +  MV+T ++Y+F Y+ ALEY
Sbjct: 1397 CLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY 1456

Query: 1902 LGSF 1905
            L SF
Sbjct: 1457 LSSF 1460



 Score = 87.8 bits (216), Expect = 9e-17
 Identities = 114/437 (26%), Positives = 182/437 (41%), Gaps = 50/437 (11%)

Query: 229 RVAPRFSILPMSHEIMPGGNVNITCVAVGSPMPYVK-WMQ---GAEDLTPEDDMPVGRNV 284
           R AP F  L  + E+  G N    C+A G    + K W+Q   G +       +   R  
Sbjct: 190 RKAPHFLRL-QNVEVNVGQNATFQCIAGGKWSQHDKLWLQQWNGRDTALMVTRVVNHRRF 248

Query: 285 LELTDVKDSAN-----YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITIT 338
                V D+A      Y CV  S  G  +   A++ VK  P     P   E  A   T  
Sbjct: 249 SATVSVADTAQRSVSKYRCVIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGATYL 305

Query: 339 WDSGNPD------PVSYYVIEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--S 390
           W   N +      P+    +EY++ +  G +     + +  Y +  L P+ EYEI V  +
Sbjct: 306 WIKPNANSIIGDGPIILKEVEYRTTT--GTWAETHIVDSPNYKLWHLDPDVEYEIRVLLT 363

Query: 391 AVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNG--LIRGYR 448
                G GPP   + TRT    P   P+NV+   + A  + +QW    EP G  + R + 
Sbjct: 364 RPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQW----EPFGYAVTRCHS 419

Query: 449 VYYTMEPEHPVGNWQKHNVDDSLLTTVGSLLED--ETYTVRVLAFTSVGDGPL-SDPIQV 505
              T++ ++ V N Q++  ++ + T+    L       T+R+    S  +G + S+ + V
Sbjct: 420 YNLTVQYQY-VFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVV 478

Query: 506 KTQQGVPGQ-PMNLRAEARSETSITLSWSPPRQES--IIKYELLFR-------EGDHGRE 555
           +T++ VPG  P+        E  I + W PP + +  I  YE+ ++         D   +
Sbjct: 479 QTEEDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQ 538

Query: 556 VGRTFD--PTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPV-VRQRTLQSKPSAPPQDV 612
            G+ F     T ++   L P T Y+F + A + +G G   PV  R  T  S PS P  D 
Sbjct: 539 RGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKGFG--PPVTTRIATKISAPSMPEYDT 596

Query: 613 KC-VSVRSTAILVSWRP 628
              ++   T I V  +P
Sbjct: 597 DTPLNETDTTITVMLKP 613



 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 83/351 (23%), Positives = 124/351 (35%), Gaps = 26/351 (7%)

Query: 403 SVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNW 462
           S V+   E      P  +    L A      W +P   + +  G  +   +E     G W
Sbjct: 275 SGVSNYAELIVKEPPTPIAPPELLAVGATYLWIKPNANSIIGDGPIILKEVEYRTTTGTW 334

Query: 463 QKHNVDDSLLTTVGSLLEDETYTVRVLAFT--SVGDGPLSDPIQVKTQQGVPGQ-PMNLR 519
            + ++ DS    +  L  D  Y +RVL       G GP   P+  +T+   P   P N+ 
Sbjct: 335 AETHIVDSPNYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTTRTKCADPVHGPQNVE 394

Query: 520 AEARSETSITLSWSP--------PRQESIIKYELLFREGDHGREVGRTFDPTTSYVVEDL 571
                   +TL W P              ++Y+ +F +  +  E       ++ Y +  L
Sbjct: 395 IVDIRARQLTLQWEPFGYAVTRCHSYNLTVQYQYVFNQQQY--EAEEVIQTSSHYTLRGL 452

Query: 572 KPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPP 631
           +P      RL   +P+G      +V Q T +  P A P +          I + W+PP  
Sbjct: 453 RPFMTIRLRLLLSNPEGRMESEELVVQ-TEEDVPGAVPLESIQGGPFEEKIYIQWKPPN- 510

Query: 632 ETHNGALVGYSVRYRPLGSEDPEPKEVNGIPP-----TTTQILLEALEKWTQYRITTVAH 686
           ET NG +  Y + Y+ +GS DP     +           T  L   L   T Y  T  A 
Sbjct: 511 ET-NGVITLYEINYKAVGSLDPSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKAS 569

Query: 687 TEVGPGPESSPVVVR--TDEDVPSAPPRKVEAEALNATAIRVLWRSPAPGR 735
           T  G GP   PV  R  T    PS P    +           +   PA  R
Sbjct: 570 TAKGFGP---PVTTRIATKISAPSMPEYDTDTPLNETDTTITVMLKPAQSR 617



 Score = 62.0 bits (149), Expect = 5e-09
 Identities = 86/354 (24%), Positives = 128/354 (36%), Gaps = 35/354 (9%)

Query: 665  TTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAI 724
            T  +   A    ++YR   V  ++ G G  +   ++  +   P APP   E  A+ AT  
Sbjct: 251  TVSVADTAQRSVSKYRC--VIRSDGGSGVSNYAELIVKEPPTPIAPP---ELLAVGAT-- 303

Query: 725  RVLWRSPAPGR--QHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETA 782
              LW  P        G I   +V Y    G  A       +  + D+    + +L P+  
Sbjct: 304  -YLWIKPNANSIIGDGPIILKEVEYRTTTGTWA-------ETHIVDSPNYKLWHLDPDVE 355

Query: 783  YSITVAAYTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLAR-----WEPPAGTA 837
            Y I V   T  G+G    P   +T       P    Q      + AR     WEP  G A
Sbjct: 356  YEIRVLL-TRPGEGGTGPPGPPLTTRTKCADPVHGPQNVEIVDIRARQLTLQWEP-FGYA 413

Query: 838  EDQVLGYRLQFGRE---DSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE 894
              +   Y L    +   +       E   +   YT  G+    T   RL   +  G  E 
Sbjct: 414  VTRCHSYNLTVQYQYVFNQQQYEAEEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMES 473

Query: 895  AAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKYTVAVREAGALG 954
               V+   ED P   P +    G      + ++W PP   E NG I  Y +  +  G+L 
Sbjct: 474  EELVVQTEEDVPGAVP-LESIQGGPFEEKIYIQWKPP--NETNGVITLYEINYKAVGSLD 530

Query: 955  PARE--TELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYR 1006
            P+ +  ++     +   E      GL P T Y   ++A T +G   F PPV  R
Sbjct: 531  PSADLSSQRGKVFKLRNETHHLFVGLYPGTTYSFTIKASTAKG---FGPPVTTR 581


>gi|194097398 protein tyrosine phosphatase, receptor type, G precursor
            [Homo sapiens]
          Length = 1445

 Score =  456 bits (1173), Expect = e-127
 Identities = 267/687 (38%), Positives = 378/687 (55%), Gaps = 55/687 (8%)

Query: 1263 WVIGPVL--AVVFI-ICIVIAILLY----------------KNKPDSKRKDSEPRTKCLL 1303
            W+I  ++  A+ F+ + ++IA+L+Y                +  P S  +  +   KC  
Sbjct: 737  WIIPLIVVSALTFVCLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCF- 795

Query: 1304 NNADLAPHHPKDPVEMRRINFQTPGMLSHPP----IPIADMAEHTERLKANDSLKLSQEY 1359
                 A  + +D    R +  ++  ++  P     IP+    +H   L +N+    S+++
Sbjct: 796  ---QTAHFYVEDSSSPRVVPNESIPIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDF 852

Query: 1360 ESID---PGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEG--IMGSDYINANYV 1414
            E +         T EHSN   NK KNRY N++AYDHSRV L+P+ G     SDYINANYV
Sbjct: 853  EEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYV 912

Query: 1415 DGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRGTET 1474
            DGY    AYIATQGPL  TF DFWRM+WEQ +  IVM+T L EK R KCDQYWP   +E 
Sbjct: 913  DGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEE 972

Query: 1475 YGFIQVTLLDTIELATFCVRTFSLHKN-----------GSSEKREVRQFQFTAWPDHGVP 1523
            YG I VTL  T   A + VR FS+              G   +R V Q+ +T WPD GVP
Sbjct: 973  YGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDMGVP 1032

Query: 1524 EYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHV 1583
            EY  P L F+RR      P+ GP++VHCSAGVGRTG +IVID+ML++IK + TV+V G +
Sbjct: 1033 EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFL 1092

Query: 1584 TLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGME 1643
              +R+QRNY+VQTE+QY FIH+ALLEA+    TEV +  L++Y+  +     G   T +E
Sbjct: 1093 KHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVNSILIPGVGGK-TRLE 1151

Query: 1644 LEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFI 1703
             +FK +    A      SA   CNK KNR  +++P E  RV L P+ G++G+DYINAS+I
Sbjct: 1152 KQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYI 1211

Query: 1704 DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA-ERSA 1762
             GY +   +I TQ PL  TT+DFWRM+W++N+ I+VML   + +  ++   YWP+ E S 
Sbjct: 1212 MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREESM 1270

Query: 1763 RYQYFVV-----DPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEG 1817
              + F V     D +   N  Q I+ +F +   +D     VR FQ   WP    P S   
Sbjct: 1271 NCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST- 1329

Query: 1818 FIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKML 1877
              + I  +   +E   +DGP  VH   G    G+   L+ + +++  E  VD+FQ  KM+
Sbjct: 1330 -FELINVI--KEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMI 1386

Query: 1878 RTQRPAMVQTEDEYQFCYQAALEYLGS 1904
               RP +    ++YQF Y+A L  + +
Sbjct: 1387 NLMRPGVFTDIEQYQFIYKAMLSLVST 1413



 Score = 34.7 bits (78), Expect = 0.92
 Identities = 18/92 (19%), Positives = 41/92 (44%), Gaps = 7/92 (7%)

Query: 499 LSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWS-------PPRQESIIKYELLFREGD 551
           L +P+  +  +     P++++ +  ++T++ +SWS       PP    +I Y     E +
Sbjct: 334 LENPLGTEASKVCSSPPIHMKVQPLNQTALQVSWSQPETIYHPPIMNYMISYSWTKNEDE 393

Query: 552 HGREVGRTFDPTTSYVVEDLKPNTEYAFRLAA 583
             +   +  D      +  + P++ Y FR+ A
Sbjct: 394 KEKTFTKDSDKDLKATISHVSPDSLYLFRVQA 425



 Score = 32.3 bits (72), Expect = 4.5
 Identities = 23/85 (27%), Positives = 40/85 (47%), Gaps = 5/85 (5%)

Query: 706 VPSAPPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVM 765
           V S+PP  ++ + LN TA++V W  P     H  I  Y + Y   +  + +     KD  
Sbjct: 345 VCSSPPIHMKVQPLNQTALQVSWSQPET-IYHPPIMNYMISYSWTKNEDEKEKTFTKD-- 401

Query: 766 LADAQ-EMVITNLQPETAYSITVAA 789
            +D   +  I+++ P++ Y   V A
Sbjct: 402 -SDKDLKATISHVSPDSLYLFRVQA 425


>gi|110735404 protein tyrosine phosphatase, receptor type, U isoform 1
            precursor [Homo sapiens]
          Length = 1436

 Score =  456 bits (1173), Expect = e-127
 Identities = 322/983 (32%), Positives = 478/983 (48%), Gaps = 117/983 (11%)

Query: 1007 TFLRDQVSPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNGL-----TLDVD 1056
            TF  D+  P     + +    ++  + L WE P   N   T Y+I Y  +      ++V 
Sbjct: 478  TFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVP 537

Query: 1057 G--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTAWTAFNLLNGKP 1104
            G  RT  KL        ++L P T Y F +   T +G     L +  T  +A +  +   
Sbjct: 538  GPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYAD 596

Query: 1105 SVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQFLTPLGSPEDMD 1158
              +P  +++  I V L   Q    P+  Y +++       LR+  GGQ   P+    +  
Sbjct: 597  MPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAA 656

Query: 1159 LEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQYGGFDNRGLEP 1216
            L            R L H    E+         S LP    F  GD + Y GF N  LEP
Sbjct: 657  LA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQTYRGFWNPPLEP 698

Query: 1217 GHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIWVIGPV---LAV 1271
               Y+++  A    K E        +      ++  P  +    E +  ++G     LAV
Sbjct: 699  RKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAV 758

Query: 1272 VFIICIVIAILLYKNKPDSKRKDS------------------------------------ 1295
            + ++   I +++ K KP +  K +                                    
Sbjct: 759  LILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMD 818

Query: 1296 --------EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERL 1347
                    + R+  +   + L    P+ P   +   + T G L HP + +AD+ +H  ++
Sbjct: 819  THGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHT-GQL-HPAVRVADLLQHINQM 876

Query: 1348 KANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 1407
            K  +     QEYES   G    W+ +  +     +R   + AYD  RV L P+ G   +D
Sbjct: 877  KTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNAD 932

Query: 1408 YINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYW 1467
            YINANY+DGY   N +IATQGP PE   DFWRMVW++  ++IVM+T+L E  R+KC +YW
Sbjct: 933  YINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRVKCSRYW 992

Query: 1468 PNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPT 1527
            P   ++TYG I++ L+ T  LA + VRTF+L + G S + EVRQF FTAWP+HGVP + T
Sbjct: 993  PE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHGVPYHAT 1051

Query: 1528 PFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTLMR 1587
              LAF+RRVK   PPDAGPIV+HCSAG GRTGC+IV+D ML+  + E  VD+Y  V  + 
Sbjct: 1052 GLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYNCVKTLC 1111

Query: 1588 SQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFK 1647
            S+R  M+QTE+QY FIH+A+LEA  CG T +P     A  +++ +++P  + + +  EF+
Sbjct: 1112 SRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQLREEFQ 1171

Query: 1648 RL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDYINASFI 1703
             L              A LP N+ KNR ++++P +    CL  +   +G  ++YINA+  
Sbjct: 1172 TLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNYINAALT 1228

Query: 1704 DGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE-KCHQYWPAERSA 1762
            D Y +  A+I T  PL  TT DFWR++++   T +VML +L +      C QYWP     
Sbjct: 1229 DSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYWPEPGRQ 1288

Query: 1763 RYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPKSGEGFI 1819
            +Y    V+ M+       + R F+V +    Q     VR FQF  W   +  P S + F+
Sbjct: 1289 QYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPDSKKAFL 1348

Query: 1820 DFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRT 1879
              + +V K + + G DG   VHC  G GR+G F   + VLE +R   +VD+F   K LR 
Sbjct: 1349 HLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFAAKTLRN 1407

Query: 1880 QRPAMVQTEDEYQFCYQAALEYL 1902
             +P MV+T D+Y FCY  ALEYL
Sbjct: 1408 YKPNMVETMDQYHFCYDVALEYL 1430



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)

Query: 296 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 351
           Y CV+ +  G  +   A++ VK  P     P +     T + I  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 352 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 409
           IEY+     GP+     ++   Y +  L P++EYEI V  +     G G P   +++RT 
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 410 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469
              P  AP+ +    + A  + +QW EP+  N + R +    ++   + +G+     + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437

Query: 470 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 522
            + T       T+ +LL      VR L  T+         +  +T + VP     + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493

Query: 523 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 567
            +    E  I L W  P++ +  I +YE+ ++  +          P          T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 568 VEDLKPNTEYAFRLAARSPQGLG 590
             +L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 77/350 (22%), Positives = 118/350 (33%), Gaps = 46/350 (13%)

Query: 670 LEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWR 729
           L A+ +  Q     V+    G G  +   ++  +   P APP+ + A         ++  
Sbjct: 251 LAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRA----GPTYLIIQL 306

Query: 730 SPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAA 789
           +       G I   ++ Y RM    ARGP    +V     Q   + +L P+T Y I+V  
Sbjct: 307 NTNSIIGDGPIVRKEIEY-RM----ARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLL 359

Query: 790 YTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF- 848
            T  GDG   +P   +        P     + P+G   A  +    T + + LGY +   
Sbjct: 360 -TRPGDGGTGRPGPPLISRTKCAEP----MRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414

Query: 849 --------------GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE 894
                            + T    ++      RYT   +        RL   +  G  E 
Sbjct: 415 HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474

Query: 895 AAEVLSIPEDTPRGHPQILEAAGNASAGT-----VLLRWLPPVPAERNGAIVKYTVAVRE 949
                   ED P G       A  +   T     + L+W    P E NG I +Y ++ + 
Sbjct: 475 KEVTFQTDEDVPSG------IAAESLTFTPLEDMIFLKW--EEPQEPNGLITQYEISYQS 526

Query: 950 AGALGPARETELPAAAEPGAENAL--TLQGLKPDTAYDLQVRAHTRRGPG 997
             +  PA     P        N        L P T Y   VRA T +G G
Sbjct: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 85/405 (20%), Positives = 146/405 (36%), Gaps = 51/405 (12%)

Query: 579 FRLAARSPQGLGA--FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNG 636
           +R  +++P+G G   F  ++ +      P APPQ ++      T +++       + +  
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEP--PTPIAPPQLLRA---GPTYLII-------QLNTN 309

Query: 637 ALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKW-----TQYRITTVAHT--EV 689
           +++G      P+  ++ E +   G       + L+  + W     T+Y I+ +     + 
Sbjct: 310 SIIGDG----PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDG 365

Query: 690 GPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPG--RQHGQIRGYQVHY 747
           G G    P++ RT    P   P+ +    + A  + + W        R H        HY
Sbjct: 366 GTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHY 425

Query: 748 VRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTK 807
                        +K           I NL P     + +     +G     +      +
Sbjct: 426 TLGSSHNQTIRECVKTEQ--GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDE 483

Query: 808 GAVLGRPTLSVQQTP-EGSLLARWEPPAGTAEDQVLGYRLQFGREDST--------PLAT 858
               G    S+  TP E  +  +WE P       +  Y + +   +S+        P  T
Sbjct: 484 DVPSGIAAESLTFTPLEDMIFLKWEEPQ-EPNGLITQYEISYQSIESSDPAVNVPGPRRT 542

Query: 859 LEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGE----EAAEVLSIPEDTPRGHPQILE 914
           +    +E  +  S +H G TY+F + AR+  G G+    E    +S P       P  L 
Sbjct: 543 ISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLG 602

Query: 915 AAGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGPARE 958
            + N    TVLLR     PA+  GA I  Y V V E  A    RE
Sbjct: 603 ESENTI--TVLLR-----PAQGRGAPISVYQVIVEEERARRLRRE 640


>gi|110735406 protein tyrosine phosphatase, receptor type, U isoform 2
            precursor [Homo sapiens]
          Length = 1442

 Score =  449 bits (1156), Expect = e-126
 Identities = 322/989 (32%), Positives = 478/989 (48%), Gaps = 123/989 (12%)

Query: 1007 TFLRDQVSPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNGL-----TLDVD 1056
            TF  D+  P     + +    ++  + L WE P   N   T Y+I Y  +      ++V 
Sbjct: 478  TFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVP 537

Query: 1057 G--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTAWTAFNLLNGKP 1104
            G  RT  KL        ++L P T Y F +   T +G     L +  T  +A +  +   
Sbjct: 538  GPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYAD 596

Query: 1105 SVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQFLTPLGSPEDMD 1158
              +P  +++  I V L   Q    P+  Y +++       LR+  GGQ   P+    +  
Sbjct: 597  MPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAA 656

Query: 1159 LEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQYGGFDNRGLEP 1216
            L            R L H    E+         S LP    F  GD + Y GF N  LEP
Sbjct: 657  LA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQTYRGFWNPPLEP 698

Query: 1217 GHRYVLFVLAVLQ-KSEPTFAASPFSDPFQL-DNPDPQPIVDGEEGLIWVIGPV---LAV 1271
               Y+++  A    K E        +      ++  P  +    E +  ++G     LAV
Sbjct: 699  RKAYLIYFQAASHLKGETRLNCIRIARKAACKESKRPLEVSQRSEEMGLILGICAGGLAV 758

Query: 1272 VFIICIVIAILLYKNKPDSKRKDS------------------------------------ 1295
            + ++   I +++ K KP +  K +                                    
Sbjct: 759  LILLLGAIIVIIRKGKPVNMTKATVNYRQEKTHMMSAVDRSFTDQSTLQEDERLGLSFMD 818

Query: 1296 --------EPRTKCLLNNADLAPHHPKDPVEMRRINFQTPGMLSHPPIPIADMAEHTERL 1347
                    + R+  +   + L    P+ P   +   + T G L HP + +AD+ +H  ++
Sbjct: 819  THGYSTRGDQRSGGVTEASSLLGGSPRRPCGRKGSPYHT-GQL-HPAVRVADLLQHINQM 876

Query: 1348 KANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSD 1407
            K  +     QEYES   G    W+ +  +     +R   + AYD  RV L P+ G   +D
Sbjct: 877  KTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYDRHRVKLHPMLGDPNAD 932

Query: 1408 YINANYVD------GYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRI 1461
            YINANY+D      GY   N +IATQGP PE   DFWRMVW++  ++IVM+T+L E  R+
Sbjct: 933  YINANYIDIRINREGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVMITKLVEVGRV 992

Query: 1462 KCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHG 1521
            KC +YWP   ++TYG I++ L+ T  LA + VRTF+L + G S + EVRQF FTAWP+HG
Sbjct: 993  KCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQFHFTAWPEHG 1051

Query: 1522 VPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYG 1581
            VP + T  LAF+RRVK   PPDAGPIV+HCSAG GRTGC+IV+D ML+  + E  VD+Y 
Sbjct: 1052 VPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMAECEGVVDIYN 1111

Query: 1582 HVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTG 1641
             V  + S+R  M+QTE+QY FIH+A+LEA  CG T +P     A  +++ +++P  + + 
Sbjct: 1112 CVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMIRIDPQSNSSQ 1171

Query: 1642 MELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEG--SDY 1697
            +  EF+ L              A LP N+ KNR ++++P +    CL  +   +G  ++Y
Sbjct: 1172 LREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFLISTDGDSNNY 1228

Query: 1698 INASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGRE-KCHQYW 1756
            INA+  D Y +  A+I T  PL  TT DFWR++++   T +VML +L +      C QYW
Sbjct: 1229 INAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQSNSAWPCLQYW 1288

Query: 1757 PAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFTDWPE-QGVPK 1813
            P     +Y    V+ M+       + R F+V +    Q     VR FQF  W   +  P 
Sbjct: 1289 PEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFLRWSAYRDTPD 1348

Query: 1814 SGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQT 1873
            S + F+  + +V K + + G DG   VHC  G GR+G F   + VLE +R   +VD+F  
Sbjct: 1349 SKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIRCHNLVDVFFA 1407

Query: 1874 VKMLRTQRPAMVQTEDEYQFCYQAALEYL 1902
             K LR  +P MV+T D+Y FCY  ALEYL
Sbjct: 1408 AKTLRNYKPNMVETMDQYHFCYDVALEYL 1436



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)

Query: 296 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 351
           Y CV+ +  G  +   A++ VK  P     P +     T + I  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 352 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 409
           IEY+     GP+     ++   Y +  L P++EYEI V  +     G G P   +++RT 
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 410 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469
              P  AP+ +    + A  + +QW EP+  N + R +    ++   + +G+     + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437

Query: 470 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 522
            + T       T+ +LL      VR L  T+         +  +T + VP     + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493

Query: 523 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 567
            +    E  I L W  P++ +  I +YE+ ++  +          P          T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 568 VEDLKPNTEYAFRLAARSPQGLG 590
             +L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 77/350 (22%), Positives = 118/350 (33%), Gaps = 46/350 (13%)

Query: 670 LEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWR 729
           L A+ +  Q     V+    G G  +   ++  +   P APP+ + A         ++  
Sbjct: 251 LAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRA----GPTYLIIQL 306

Query: 730 SPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAA 789
           +       G I   ++ Y RM    ARGP    +V     Q   + +L P+T Y I+V  
Sbjct: 307 NTNSIIGDGPIVRKEIEY-RM----ARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLL 359

Query: 790 YTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF- 848
            T  GDG   +P   +        P     + P+G   A  +    T + + LGY +   
Sbjct: 360 -TRPGDGGTGRPGPPLISRTKCAEP----MRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414

Query: 849 --------------GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE 894
                            + T    ++      RYT   +        RL   +  G  E 
Sbjct: 415 HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474

Query: 895 AAEVLSIPEDTPRGHPQILEAAGNASAGT-----VLLRWLPPVPAERNGAIVKYTVAVRE 949
                   ED P G       A  +   T     + L+W    P E NG I +Y ++ + 
Sbjct: 475 KEVTFQTDEDVPSG------IAAESLTFTPLEDMIFLKW--EEPQEPNGLITQYEISYQS 526

Query: 950 AGALGPARETELPAAAEPGAENAL--TLQGLKPDTAYDLQVRAHTRRGPG 997
             +  PA     P        N        L P T Y   VRA T +G G
Sbjct: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 85/405 (20%), Positives = 146/405 (36%), Gaps = 51/405 (12%)

Query: 579 FRLAARSPQGLGA--FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNG 636
           +R  +++P+G G   F  ++ +      P APPQ ++      T +++       + +  
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEP--PTPIAPPQLLRA---GPTYLII-------QLNTN 309

Query: 637 ALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKW-----TQYRITTVAHT--EV 689
           +++G      P+  ++ E +   G       + L+  + W     T+Y I+ +     + 
Sbjct: 310 SIIGDG----PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDG 365

Query: 690 GPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPG--RQHGQIRGYQVHY 747
           G G    P++ RT    P   P+ +    + A  + + W        R H        HY
Sbjct: 366 GTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHY 425

Query: 748 VRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTK 807
                        +K           I NL P     + +     +G     +      +
Sbjct: 426 TLGSSHNQTIRECVKTEQ--GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDE 483

Query: 808 GAVLGRPTLSVQQTP-EGSLLARWEPPAGTAEDQVLGYRLQFGREDST--------PLAT 858
               G    S+  TP E  +  +WE P       +  Y + +   +S+        P  T
Sbjct: 484 DVPSGIAAESLTFTPLEDMIFLKWEEPQ-EPNGLITQYEISYQSIESSDPAVNVPGPRRT 542

Query: 859 LEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGE----EAAEVLSIPEDTPRGHPQILE 914
           +    +E  +  S +H G TY+F + AR+  G G+    E    +S P       P  L 
Sbjct: 543 ISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLG 602

Query: 915 AAGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGPARE 958
            + N    TVLLR     PA+  GA I  Y V V E  A    RE
Sbjct: 603 ESENTI--TVLLR-----PAQGRGAPISVYQVIVEEERARRLRRE 640


>gi|110735402 protein tyrosine phosphatase, receptor type, U isoform 3
            precursor [Homo sapiens]
          Length = 1446

 Score =  445 bits (1145), Expect = e-124
 Identities = 240/579 (41%), Positives = 340/579 (58%), Gaps = 17/579 (2%)

Query: 1332 HPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYD 1391
            HP + +AD+ +H  ++K  +     QEYES   G    W+ +  +     +R   + AYD
Sbjct: 871  HPAVRVADLLQHINQMKTAEGYGFKQEYESFFEG----WDATKKKDKVKGSRQEPMPAYD 926

Query: 1392 HSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVM 1451
              RV L P+ G   +DYINANY+DGY   N +IATQGP PE   DFWRMVW++  ++IVM
Sbjct: 927  RHRVKLHPMLGDPNADYINANYIDGYHRSNHFIATQGPKPEMVYDFWRMVWQEHCSSIVM 986

Query: 1452 MTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQ 1511
            +T+L E  R+KC +YWP   ++TYG I++ L+ T  LA + VRTF+L + G S + EVRQ
Sbjct: 987  ITKLVEVGRVKCSRYWPE-DSDTYGDIKIMLVKTETLAEYVVRTFALERRGYSARHEVRQ 1045

Query: 1512 FQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI 1571
            F FTAWP+HGVP + T  LAF+RRVK   PPDAGPIV+HCSAG GRTGC+IV+D ML+  
Sbjct: 1046 FHFTAWPEHGVPYHATGLLAFIRRVKASTPPDAGPIVIHCSAGTGRTGCYIVLDVMLDMA 1105

Query: 1572 KPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLA 1631
            + E  VD+Y  V  + S+R  M+QTE+QY FIH+A+LEA  CG T +P     A  +++ 
Sbjct: 1106 ECEGVVDIYNCVKTLCSRRVNMIQTEEQYIFIHDAILEACLCGETTIPVSEFKATYKEMI 1165

Query: 1632 QVEPGEHVTGMELEFKRL--ANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPI 1689
            +++P  + + +  EF+ L              A LP N+ KNR ++++P +    CL  +
Sbjct: 1166 RIDPQSNSSQLREEFQTLNSVTPPLDVEECSIALLPRNRDKNRSMDVLPPDR---CLPFL 1222

Query: 1690 RGVEG--SDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREM 1747
               +G  ++YINA+  D Y +  A+I T  PL  TT DFWR++++   T +VML +L + 
Sbjct: 1223 ISTDGDSNNYINAALTDSYTRSAAFIVTLHPLQSTTPDFWRLVYDYGCTSIVMLNQLNQS 1282

Query: 1748 GRE-KCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQS--RTVRQFQFT 1804
                 C QYWP     +Y    V+ M+       + R F+V +    Q     VR FQF 
Sbjct: 1283 NSAWPCLQYWPEPGRQQYGLMEVEFMSGTADEDLVARVFRVQNISRLQEGHLLVRHFQFL 1342

Query: 1805 DWPE-QGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMR 1863
             W   +  P S + F+  + +V K + + G DG   VHC  G GR+G F   + VLE +R
Sbjct: 1343 RWSAYRDTPDSKKAFLHLLAEVDKWQAESG-DGRTIVHCLNGGGRSGTFCACATVLEMIR 1401

Query: 1864 YEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYL 1902
               +VD+F   K LR  +P MV+T D+Y FCY  ALEYL
Sbjct: 1402 CHNLVDVFFAAKTLRNYKPNMVETMDQYHFCYDVALEYL 1440



 Score = 63.5 bits (153), Expect = 2e-09
 Identities = 74/323 (22%), Positives = 134/323 (41%), Gaps = 36/323 (11%)

Query: 296 YTCVAMSSLGV-IEAVAQITVKSLPKAPGTPMVTENTATSITITWDSGN---PDPVSYYV 351
           Y CV+ +  G  +   A++ VK  P     P +     T + I  ++ +     P+    
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRAGPTYLIIQLNTNSIIGDGPIVRKE 321

Query: 352 IEYKSKSQDGPYQIKEDITTTRYSIGGLSPNSEYEIWV--SAVNSIGQGPPSESVVTRTG 409
           IEY+     GP+     ++   Y +  L P++EYEI V  +     G G P   +++RT 
Sbjct: 322 IEYRMAR--GPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDGGTGRPGPPLISRTK 379

Query: 410 EQAPASAPRNVQARMLSATTMIVQWEEPVEPNGLIRGYRVYYTMEPEHPVGNWQKHNVDD 469
              P  AP+ +    + A  + +QW EP+  N + R +    ++   + +G+     + +
Sbjct: 380 CAEPMRAPKGLAFAEIQARQLTLQW-EPLGYN-VTRCHTYTVSLCYHYTLGSSHNQTIRE 437

Query: 470 SLLT-------TVGSLLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEA 522
            + T       T+ +LL      VR L  T+         +  +T + VP     + AE+
Sbjct: 438 CVKTEQGVSRYTIKNLLPYRNVHVR-LVLTNPEGRKEGKEVTFQTDEDVPS---GIAAES 493

Query: 523 RS----ETSITLSWSPPRQES--IIKYELLFREGDHGREVGRTFDP---------TTSYV 567
            +    E  I L W  P++ +  I +YE+ ++  +          P          T +V
Sbjct: 494 LTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVPGPRRTISKLRNETYHV 553

Query: 568 VEDLKPNTEYAFRLAARSPQGLG 590
             +L P T Y F + AR+ +G G
Sbjct: 554 FSNLHPGTTYLFSVRARTGKGFG 576



 Score = 43.5 bits (101), Expect = 0.002
 Identities = 77/350 (22%), Positives = 118/350 (33%), Gaps = 46/350 (13%)

Query: 670 LEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWR 729
           L A+ +  Q     V+    G G  +   ++  +   P APP+ + A         ++  
Sbjct: 251 LAAVSRAEQDLYRCVSQAPRGAGVSNFAELIVKEPPTPIAPPQLLRA----GPTYLIIQL 306

Query: 730 SPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAA 789
           +       G I   ++ Y RM    ARGP    +V     Q   + +L P+T Y I+V  
Sbjct: 307 NTNSIIGDGPIVRKEIEY-RM----ARGP--WAEVHAVSLQTYKLWHLDPDTEYEISVLL 359

Query: 790 YTMKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEGSLLARWEPPAGTAEDQVLGYRLQF- 848
            T  GDG   +P   +        P     + P+G   A  +    T + + LGY +   
Sbjct: 360 -TRPGDGGTGRPGPPLISRTKCAEP----MRAPKGLAFAEIQARQLTLQWEPLGYNVTRC 414

Query: 849 --------------GREDSTPLATLEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGEE 894
                            + T    ++      RYT   +        RL   +  G  E 
Sbjct: 415 HTYTVSLCYHYTLGSSHNQTIRECVKTEQGVSRYTIKNLLPYRNVHVRLVLTNPEGRKEG 474

Query: 895 AAEVLSIPEDTPRGHPQILEAAGNASAGT-----VLLRWLPPVPAERNGAIVKYTVAVRE 949
                   ED P G       A  +   T     + L+W    P E NG I +Y ++ + 
Sbjct: 475 KEVTFQTDEDVPSG------IAAESLTFTPLEDMIFLKW--EEPQEPNGLITQYEISYQS 526

Query: 950 AGALGPARETELPAAAEPGAENAL--TLQGLKPDTAYDLQVRAHTRRGPG 997
             +  PA     P        N        L P T Y   VRA T +G G
Sbjct: 527 IESSDPAVNVPGPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFG 576



 Score = 40.4 bits (93), Expect = 0.017
 Identities = 85/405 (20%), Positives = 146/405 (36%), Gaps = 51/405 (12%)

Query: 579 FRLAARSPQGLGA--FTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNG 636
           +R  +++P+G G   F  ++ +      P APPQ ++      T +++       + +  
Sbjct: 262 YRCVSQAPRGAGVSNFAELIVKEP--PTPIAPPQLLRA---GPTYLII-------QLNTN 309

Query: 637 ALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQILLEALEKW-----TQYRITTVAHT--EV 689
           +++G      P+  ++ E +   G       + L+  + W     T+Y I+ +     + 
Sbjct: 310 SIIGDG----PIVRKEIEYRMARGPWAEVHAVSLQTYKLWHLDPDTEYEISVLLTRPGDG 365

Query: 690 GPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLWRSPAPG--RQHGQIRGYQVHY 747
           G G    P++ RT    P   P+ +    + A  + + W        R H        HY
Sbjct: 366 GTGRPGPPLISRTKCAEPMRAPKGLAFAEIQARQLTLQWEPLGYNVTRCHTYTVSLCYHY 425

Query: 748 VRMEGAEARGPPRIKDVMLADAQEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVTK 807
                        +K           I NL P     + +     +G     +      +
Sbjct: 426 TLGSSHNQTIRECVKTEQ--GVSRYTIKNLLPYRNVHVRLVLTNPEGRKEGKEVTFQTDE 483

Query: 808 GAVLGRPTLSVQQTP-EGSLLARWEPPAGTAEDQVLGYRLQFGREDST--------PLAT 858
               G    S+  TP E  +  +WE P       +  Y + +   +S+        P  T
Sbjct: 484 DVPSGIAAESLTFTPLEDMIFLKWEEPQ-EPNGLITQYEISYQSIESSDPAVNVPGPRRT 542

Query: 859 LEFPPSEDRYTASGVHKGATYVFRLAARSRGGLGE----EAAEVLSIPEDTPRGHPQILE 914
           +    +E  +  S +H G TY+F + AR+  G G+    E    +S P       P  L 
Sbjct: 543 ISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSFDYADMPSPLG 602

Query: 915 AAGNASAGTVLLRWLPPVPAERNGA-IVKYTVAVREAGALGPARE 958
            + N    TVLLR     PA+  GA I  Y V V E  A    RE
Sbjct: 603 ESENTI--TVLLR-----PAQGRGAPISVYQVIVEEERARRLRRE 640



 Score = 36.2 bits (82), Expect = 0.32
 Identities = 62/250 (24%), Positives = 96/250 (38%), Gaps = 49/250 (19%)

Query: 1007 TFLRDQVSPKNFKVKMI----MKTSVLLSWEFPDNYNSP-TPYKIQYNGL-----TLDVD 1056
            TF  D+  P     + +    ++  + L WE P   N   T Y+I Y  +      ++V 
Sbjct: 478  TFQTDEDVPSGIAAESLTFTPLEDMIFLKWEEPQEPNGLITQYEISYQSIESSDPAVNVP 537

Query: 1057 G--RTTKKL-------ITHLKPHTFYNFVL---TNRGSSLGGLQQTVTAWTAFNLLNGKP 1104
            G  RT  KL        ++L P T Y F +   T +G     L +  T  +A +  +   
Sbjct: 538  GPRRTISKLRNETYHVFSNLHPGTTYLFSVRARTGKGFGQAALTEITTNISAPSF-DYAD 596

Query: 1105 SVAPKPDADGFIMVYLPDGQSP-VPVQSYFIVMVP-----LRKSRGGQFLTPLGSPEDMD 1158
              +P  +++  I V L   Q    P+  Y +++       LR+  GGQ   P+    +  
Sbjct: 597  MPSPLGESENTITVLLRPAQGRGAPISVYQVIVEEERARRLRREPGGQDCFPVPLTFEAA 656

Query: 1159 LEELIQDISRLQRRSLRHSRQLEVPRPYIAARFSVLPPT--FHPGDQKQYGGFDNRGLEP 1216
            L            R L H    E+         S LP    F  GD + Y GF N  LEP
Sbjct: 657  LA-----------RGLVHYFGAELAA-------SSLPEAMPFTVGDNQTYRGFWNPPLEP 698

Query: 1217 GHRYVLFVLA 1226
               Y+++  A
Sbjct: 699  RKAYLIYFQA 708


>gi|91208428 protein tyrosine phosphatase, receptor-type, zeta1
            precursor [Homo sapiens]
          Length = 2315

 Score =  412 bits (1058), Expect = e-114
 Identities = 241/592 (40%), Positives = 336/592 (56%), Gaps = 24/592 (4%)

Query: 1330 LSHPPIPIADMAEHTERLKANDSLK-LSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVI 1388
            + H P  +AD+   +   +  ++LK   QE +S       T + SN   NK KNRY N++
Sbjct: 1701 IKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIV 1760

Query: 1389 AYDHSRVILQPIEGIMG--SDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRS 1446
            AYDHSRV L  +    G  +DYINANYVDGY    AYIA QGPL  T  DFWRM+WE   
Sbjct: 1761 AYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV 1820

Query: 1447 ATIVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLH----KNG 1502
              IVM+T L EK R KCDQYWP  G+E YG   VT      LA + VR F+L     K G
Sbjct: 1821 EVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKG 1880

Query: 1503 SSEKRE----VRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRT 1558
            S + R     V Q+ +T WPD GVPEY  P L F+R+         GP+VVHCSAGVGRT
Sbjct: 1881 SQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRT 1940

Query: 1559 GCFIVIDAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1618
            G +IV+D+ML++I+ E TV+++G +  +RSQRNY+VQTE+QY FIH+ L+EA+    TEV
Sbjct: 1941 GTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV 2000

Query: 1619 PARSLYAYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMP 1678
                ++AY+  L    P    T +E +F+ L+ S    S + +A   CN+ KNR  +I+P
Sbjct: 2001 LDSHIHAYVNALLIPGPAGK-TKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIP 2059

Query: 1679 YESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIV 1738
             E +RV +  + G EG+DYINAS+I GY Q   +I TQ PL  T +DFWRM+W++N+ +V
Sbjct: 2060 VERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV 2118

Query: 1739 VMLTKLREMGREKCHQYWP-AERSARYQYFVVDPMAE-----YNMPQYILREFKVTDARD 1792
            VM+   + M  ++   YWP  +     + F V  MAE      N  + I+++F +   +D
Sbjct: 2119 VMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQD 2177

Query: 1793 GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVF 1852
                 VR FQ   WP    P S     + I  +   +E   +DGP+ VH   G    G F
Sbjct: 2178 DYVLEVRHFQCPKWPNPDSPISKT--FELISVI--KEEAANRDGPMIVHDEHGGVTAGTF 2233

Query: 1853 ITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS 1904
              L+ ++ ++  E  VD++Q  KM+   RP +    ++YQF Y+  L  + +
Sbjct: 2234 CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST 2285



 Score =  117 bits (292), Expect = 1e-25
 Identities = 79/278 (28%), Positives = 133/278 (47%), Gaps = 12/278 (4%)

Query: 1354 KLSQEYESIDPG--QQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINA 1411
            KL ++++ +     QQ  +  +  + N+ KNR +++I  + SRV +  + G  G+DYINA
Sbjct: 2022 KLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINA 2080

Query: 1412 NYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTRLEEKSRIKCDQYWPNRG 1471
            +Y+ GY   N +I TQ PL  T  DFWRM+W+  +  +VM+   +  +  +   YWPN+ 
Sbjct: 2081 SYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEF-VYWPNKD 2139

Query: 1472 TE-TYGFIQVTLLDTIELAT-----FCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEY 1525
                    +VTL+              ++ F L         EVR FQ   WP+   P  
Sbjct: 2140 EPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPIS 2199

Query: 1526 PTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERIKPEKTVDVYGHVTL 1585
             T  L  + + +  N    GP++VH   G    G F  +  ++ +++ E +VDVY    +
Sbjct: 2200 KTFELISVIKEEAANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKM 2257

Query: 1586 MRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSL 1623
            +   R  +    +QY F+++ +L  V     E P+ SL
Sbjct: 2258 INLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSL 2295



 Score = 33.1 bits (74), Expect = 2.7
 Identities = 22/84 (26%), Positives = 41/84 (48%), Gaps = 9/84 (10%)

Query: 514 QPMNLRAEARSETSITLSWSPPR---QESIIKYELLFREGDHGREVGRTFDPTTSY---- 566
           +P N++A+  + TS+ ++W  PR      I K+ +L+++ D   +    F  T  Y    
Sbjct: 314 EPENVQADPENYTSLLVTWERPRVVYDTMIEKFAVLYQQLDGEDQTKHEF-LTDGYQDLG 372

Query: 567 -VVEDLKPNTEYAFRLAARSPQGL 589
            ++ +L PN  Y  ++ A    GL
Sbjct: 373 AILNNLLPNMSYVLQIVAICTNGL 396


>gi|18641364 protein tyrosine phosphatase, receptor type, C isoform 3
            precursor [Homo sapiens]
          Length = 1256

 Score =  397 bits (1019), Expect = e-110
 Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)

Query: 1329 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 1387
            +++  PI    + E  +R  A++      E++SI     +F  + +    N+ KNRY ++
Sbjct: 577  LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 636

Query: 1388 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1447
            + YD++RV L  I G  GS+YINA+Y+DG++    YIA QGP  ET  DFWRM+WEQ++ 
Sbjct: 637  LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 696

Query: 1448 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1504
             IVM+TR EE +R KC +YWP+   GT  +G + V +        + ++  ++ +K   +
Sbjct: 697  VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 756

Query: 1505 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1564
              REV   QFT+WPDHGVPE P   L   RRV   +   +GPIVVHCSAGVGRTG +I I
Sbjct: 757  TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 816

Query: 1565 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1624
            DAMLE ++ E  VDVYG+V  +R QR  MVQ E QY  IH+AL+E    G TEV    L+
Sbjct: 817  DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 876

Query: 1625 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1684
             Y+  + + +P    + +E EF+RL + ++  ++ I  N   NK KNR  N++PY+  RV
Sbjct: 877  PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 935

Query: 1685 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1725
             L+                        E S YINASFI  Y + +  IA QGPL ET  D
Sbjct: 936  PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 995

Query: 1726 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1785
            FW+M+++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F
Sbjct: 996  FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 1054

Query: 1786 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1837
            ++  ++   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P
Sbjct: 1055 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1114

Query: 1838 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1895
            + +HC  G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T ++YQF Y
Sbjct: 1115 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1172



 Score =  198 bits (503), Expect = 5e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1662 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1721
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 622  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 681

Query: 1722 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1779
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 682  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 741

Query: 1780 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1838
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 742  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 799

Query: 1839 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1898
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E +Y   +QA 
Sbjct: 800  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 859

Query: 1899 LEY 1901
            +EY
Sbjct: 860  VEY 862



 Score =  155 bits (392), Expect = 4e-37
 Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)

Query: 1355 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 1398
            L  E++ +   + +  +H  N E NK KNR +NVI YD++RV L+               
Sbjct: 894  LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 953

Query: 1399 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1454
                  +    S YINA+++  Y      IA QGPL ET GDFW+M+++++   IVM+T 
Sbjct: 954  SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1013

Query: 1455 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1514
            L+   +  C QYW   G +TYG I+V L DT + +T+ +R F L  +   + R V Q+Q+
Sbjct: 1014 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1072

Query: 1515 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1564
            T W    +P  P   ++ ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 1073 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1132

Query: 1565 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1618
              +LE  + E+ VD++  V  +R  R  MV T +QY F+++ +       N +V
Sbjct: 1133 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1186



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 17/133 (12%)

Query: 505 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 564
           +KT  G PG+P  +   + +     ++W+PP Q S   + L + + +  ++         
Sbjct: 335 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 392

Query: 565 SYVVEDLKPNTEY-----AFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRS 619
            Y +++LKP T+Y     A+ +A     G  A      +       SAPP  V  ++V  
Sbjct: 393 KYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-------SAPPSQVWNMTVSM 445

Query: 620 T---AILVSWRPP 629
           T   ++ V  RPP
Sbjct: 446 TSDNSMHVKCRPP 458


>gi|18641347 protein tyrosine phosphatase, receptor type, C isoform 1
            precursor [Homo sapiens]
          Length = 1304

 Score =  397 bits (1019), Expect = e-110
 Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)

Query: 1329 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 1387
            +++  PI    + E  +R  A++      E++SI     +F  + +    N+ KNRY ++
Sbjct: 625  LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 684

Query: 1388 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1447
            + YD++RV L  I G  GS+YINA+Y+DG++    YIA QGP  ET  DFWRM+WEQ++ 
Sbjct: 685  LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 744

Query: 1448 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1504
             IVM+TR EE +R KC +YWP+   GT  +G + V +        + ++  ++ +K   +
Sbjct: 745  VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 804

Query: 1505 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1564
              REV   QFT+WPDHGVPE P   L   RRV   +   +GPIVVHCSAGVGRTG +I I
Sbjct: 805  TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 864

Query: 1565 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1624
            DAMLE ++ E  VDVYG+V  +R QR  MVQ E QY  IH+AL+E    G TEV    L+
Sbjct: 865  DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 924

Query: 1625 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1684
             Y+  + + +P    + +E EF+RL + ++  ++ I  N   NK KNR  N++PY+  RV
Sbjct: 925  PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 983

Query: 1685 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1725
             L+                        E S YINASFI  Y + +  IA QGPL ET  D
Sbjct: 984  PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 1043

Query: 1726 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1785
            FW+M+++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F
Sbjct: 1044 FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 1102

Query: 1786 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1837
            ++  ++   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P
Sbjct: 1103 ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1162

Query: 1838 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1895
            + +HC  G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T ++YQF Y
Sbjct: 1163 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1220



 Score =  198 bits (503), Expect = 5e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1662 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1721
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 670  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 729

Query: 1722 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1779
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 730  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 789

Query: 1780 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1838
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 790  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 847

Query: 1839 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1898
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E +Y   +QA 
Sbjct: 848  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 907

Query: 1899 LEY 1901
            +EY
Sbjct: 908  VEY 910



 Score =  155 bits (392), Expect = 4e-37
 Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)

Query: 1355 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 1398
            L  E++ +   + +  +H  N E NK KNR +NVI YD++RV L+               
Sbjct: 942  LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 1001

Query: 1399 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1454
                  +    S YINA+++  Y      IA QGPL ET GDFW+M+++++   IVM+T 
Sbjct: 1002 SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 1061

Query: 1455 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1514
            L+   +  C QYW   G +TYG I+V L DT + +T+ +R F L  +   + R V Q+Q+
Sbjct: 1062 LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 1120

Query: 1515 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1564
            T W    +P  P   ++ ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 1121 TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1180

Query: 1565 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1618
              +LE  + E+ VD++  V  +R  R  MV T +QY F+++ +       N +V
Sbjct: 1181 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1234



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 17/133 (12%)

Query: 505 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 564
           +KT  G PG+P  +   + +     ++W+PP Q S   + L + + +  ++         
Sbjct: 383 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 440

Query: 565 SYVVEDLKPNTEY-----AFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRS 619
            Y +++LKP T+Y     A+ +A     G  A      +       SAPP  V  ++V  
Sbjct: 441 KYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-------SAPPSQVWNMTVSM 493

Query: 620 T---AILVSWRPP 629
           T   ++ V  RPP
Sbjct: 494 TSDNSMHVKCRPP 506


>gi|18641362 protein tyrosine phosphatase, receptor type, C isoform 2
            precursor [Homo sapiens]
          Length = 1143

 Score =  397 bits (1019), Expect = e-110
 Identities = 235/598 (39%), Positives = 333/598 (55%), Gaps = 33/598 (5%)

Query: 1329 MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPG-QQFTWEHSNLEVNKPKNRYANV 1387
            +++  PI    + E  +R  A++      E++SI     +F  + +    N+ KNRY ++
Sbjct: 464  LMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDI 523

Query: 1388 IAYDHSRVILQPIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSA 1447
            + YD++RV L  I G  GS+YINA+Y+DG++    YIA QGP  ET  DFWRM+WEQ++ 
Sbjct: 524  LPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKAT 583

Query: 1448 TIVMMTRLEEKSRIKCDQYWPN--RGTETYGFIQVTLLDTIELATFCVRTFSL-HKNGSS 1504
             IVM+TR EE +R KC +YWP+   GT  +G + V +        + ++  ++ +K   +
Sbjct: 584  VIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKA 643

Query: 1505 EKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVI 1564
              REV   QFT+WPDHGVPE P   L   RRV   +   +GPIVVHCSAGVGRTG +I I
Sbjct: 644  TGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGI 703

Query: 1565 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLY 1624
            DAMLE ++ E  VDVYG+V  +R QR  MVQ E QY  IH+AL+E    G TEV    L+
Sbjct: 704  DAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELH 763

Query: 1625 AYIQKLAQVEPGEHVTGMELEFKRLANSKAHTSRFISANLPCNKFKNRLVNIMPYESTRV 1684
             Y+  + + +P    + +E EF+RL + ++  ++ I  N   NK KNR  N++PY+  RV
Sbjct: 764  PYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHI-GNQEENKSKNRNSNVIPYDYNRV 822

Query: 1685 CLQ-------------------PIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTED 1725
             L+                        E S YINASFI  Y + +  IA QGPL ET  D
Sbjct: 823  PLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGD 882

Query: 1726 FWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREF 1785
            FW+M+++    ++VMLT+L+   +E C QYW  E    Y    VD         Y LR F
Sbjct: 883  FWQMIFQRKVKVIVMLTELKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVF 941

Query: 1786 KVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQV-HKTKEQFGQDG-------P 1837
            ++  ++   SRTV Q+Q+T+W  + +P   +  I  I  V  K  ++   +G       P
Sbjct: 942  ELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTP 1001

Query: 1838 ISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCY 1895
            + +HC  G  +TG+F  L  +LE    E VVDIFQ VK LR  RP MV T ++YQF Y
Sbjct: 1002 LLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLY 1059



 Score =  198 bits (503), Expect = 5e-50
 Identities = 103/243 (42%), Positives = 145/243 (59%), Gaps = 5/243 (2%)

Query: 1662 ANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAE 1721
            A  P N+ KNR V+I+PY+  RV L  I G  GS+YINAS+IDG+++ + YIA QGP  E
Sbjct: 509  ARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDE 568

Query: 1722 TTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPA--ERSARYQYFVVDPMAEYNMPQ 1779
            T +DFWRM+WE  +T++VM+T+  E  R KC +YWP+  E +  +   VV        P 
Sbjct: 569  TVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPD 628

Query: 1780 YILREFKVTDARD-GQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPI 1838
            YI+++  + + ++    R V   QFT WP+ GVP+     +    +V+     F   GPI
Sbjct: 629  YIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFS--GPI 686

Query: 1839 SVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAA 1898
             VHCSAGVGRTG +I +  +LE +  E  VD++  V  LR QR  MVQ E +Y   +QA 
Sbjct: 687  VVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQAL 746

Query: 1899 LEY 1901
            +EY
Sbjct: 747  VEY 749



 Score =  155 bits (392), Expect = 4e-37
 Identities = 93/294 (31%), Positives = 149/294 (50%), Gaps = 31/294 (10%)

Query: 1355 LSQEYESIDPGQQFTWEH-SNLEVNKPKNRYANVIAYDHSRVILQ--------------- 1398
            L  E++ +   + +  +H  N E NK KNR +NVI YD++RV L+               
Sbjct: 781  LEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDE 840

Query: 1399 ----PIEGIMGSDYINANYVDGYRCQNAYIATQGPLPETFGDFWRMVWEQRSATIVMMTR 1454
                  +    S YINA+++  Y      IA QGPL ET GDFW+M+++++   IVM+T 
Sbjct: 841  SSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTE 900

Query: 1455 LEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQF 1514
            L+   +  C QYW   G +TYG I+V L DT + +T+ +R F L  +   + R V Q+Q+
Sbjct: 901  LKHGDQEICAQYW-GEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQY 959

Query: 1515 TAWPDHGVPEYPTPFLAFLRRVKTCNPPD----------AGPIVVHCSAGVGRTGCFIVI 1564
            T W    +P  P   ++ ++ VK   P            + P+++HC  G  +TG F  +
Sbjct: 960  TNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCAL 1019

Query: 1565 DAMLERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEV 1618
              +LE  + E+ VD++  V  +R  R  MV T +QY F+++ +       N +V
Sbjct: 1020 LNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQV 1073



 Score = 33.9 bits (76), Expect = 1.6
 Identities = 33/133 (24%), Positives = 58/133 (43%), Gaps = 17/133 (12%)

Query: 505 VKTQQGVPGQPMNLRAEARSETSITLSWSPPRQESIIKYELLFREGDHGREVGRTFDPTT 564
           +KT  G PG+P  +   + +     ++W+PP Q S   + L + + +  ++         
Sbjct: 222 IKTDFGSPGEPQIIFCRSEAAHQGVITWNPP-QRSFHNFTLCYIK-ETEKDCLNLDKNLI 279

Query: 565 SYVVEDLKPNTEY-----AFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQDVKCVSVRS 619
            Y +++LKP T+Y     A+ +A     G  A      +       SAPP  V  ++V  
Sbjct: 280 KYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTK-------SAPPSQVWNMTVSM 332

Query: 620 T---AILVSWRPP 629
           T   ++ V  RPP
Sbjct: 333 TSDNSMHVKCRPP 345


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.405 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 82,352,515
Number of Sequences: 37866
Number of extensions: 4210397
Number of successful extensions: 21918
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 324
Number of HSP's successfully gapped in prelim test: 220
Number of HSP's that attempted gapping in prelim test: 9766
Number of HSP's gapped (non-prelim): 4073
length of query: 1910
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1793
effective length of database: 13,817,196
effective search space: 24774232428
effective search space used: 24774232428
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 70 (31.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.