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Search of human proteins with 18252778
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18252778 ankyrin repeat and SOCS box-containing protein 2
[Homo sapiens]
(587 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Ho... 1182 0.0
gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo sapi... 325 7e-89
gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1... 282 5e-76
gi|18390333 ankyrin repeat and SOCS box-containing 14 isoform 2 ... 191 2e-48
gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isof... 189 8e-48
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 166 6e-41
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 166 6e-41
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 166 6e-41
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 152 1e-36
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 150 2e-36
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 150 2e-36
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 150 2e-36
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 150 2e-36
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 150 2e-36
gi|22208951 ankyrin repeat and SOCS box-containing protein 3 iso... 150 2e-36
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 140 3e-33
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 140 3e-33
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 140 3e-33
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 140 3e-33
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 140 3e-33
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 139 6e-33
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 139 9e-33
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 139 9e-33
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 134 2e-31
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 131 2e-30
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 128 2e-29
gi|70995267 ankyrin repeat domain 29 [Homo sapiens] 123 5e-28
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 122 7e-28
gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens] 122 1e-27
gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens] 122 1e-27
>gi|18252778 ankyrin repeat and SOCS box-containing protein 2 [Homo
sapiens]
Length = 587
Score = 1182 bits (3059), Expect = 0.0
Identities = 587/587 (100%), Positives = 587/587 (100%)
Query: 1 MTRFSYAEYFSLFHSCSAPSRSTAPPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADP 60
MTRFSYAEYFSLFHSCSAPSRSTAPPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADP
Sbjct: 1 MTRFSYAEYFSLFHSCSAPSRSTAPPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADP 60
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR
Sbjct: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN
Sbjct: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR
Sbjct: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
Query: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKG 300
FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKG
Sbjct: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKG 300
Query: 301 NYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYE 360
NYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYE
Sbjct: 301 NYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYE 360
Query: 361 DRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANID 420
DRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANID
Sbjct: 361 DRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANID 420
Query: 421 AYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDA 480
AYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDA
Sbjct: 421 AYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDA 480
Query: 481 PAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKE 540
PAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKE
Sbjct: 481 PAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKE 540
Query: 541 KAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ 587
KAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
Sbjct: 541 KAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ 587
>gi|92087060 ankyrin repeat and SOCS box-containing 15 [Homo
sapiens]
Length = 588
Score = 325 bits (833), Expect = 7e-89
Identities = 183/532 (34%), Positives = 300/532 (56%), Gaps = 10/532 (1%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK-VLQRAYPGTIDQ 119
L++AIK G L+ +K + E +++GW PLHEA L+ VL +Y +
Sbjct: 47 LVEAIKQGHIPELQEYVKYKYAMDEADEKGWFPLHEAVVQPIQQILEIVLDASYKTLWEF 106
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+T ET + LA G ++ + +LL+ G P+ N ETPL A ++ + + V L++H
Sbjct: 107 KTCDGETPLTLAVKAGLVENVRTLLEKGVWPNTKNDKGETPLLIAVKKGSYDMVSTLIKH 166
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
N + C + W+A+HE+ + +++ +L+ G V ++ +G+TPL VAA+ G + L
Sbjct: 167 NTSLDQPCVKRWSAMHEAAKQGRKDIVALLLKHGGNVHLRDGFGVTPLGVAAEYGHCDVL 226
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
L G D+ A D AS L+EA + + + LL G N N+ G LP+H A+ +
Sbjct: 227 EHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYE 286
Query: 300 GNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359
G+Y ++ L+PVTS+ IR+SG++P+H AA+ + + LE L+ FDVNT LA ++ Y
Sbjct: 287 GHYLALKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLIENGFDVNTLLADHISQSY 346
Query: 360 EDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANI 419
+D R +ALYF V NN+V+ TE+LL GADPN D ++ LLVA+R ++LLL HGAN+
Sbjct: 347 DDERKTALYFGVSNNDVHCTEVLLAAGADPNLDPLNCLLVAVRANNYEIVRLLLSHGANV 406
Query: 420 DAYIA-THPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFN 478
+ Y + T FP+ I +A+ +L+ L++ G E CF C++G+ S
Sbjct: 407 NCYFMHVNDTRFPSVIQYALNDEVMLRLLLNNGYQVEMCFDCMHGDIFGNSFVW--SEIQ 464
Query: 479 DAPAADKEPSVVQ---FCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDW 535
+ V++ FCEF++ P + G + VL+DY+ V LC++LK ++ +W
Sbjct: 465 EEVLPGWTSCVIKDNPFCEFITVPWMKHLVGRVTRVLIDYMDYVPLCAKLKSALEVQREW 524
Query: 536 AVIKEKAEPPRPLAHLCRLRVRKAIGKYRI---KLLDTLPLPGRLIRYLKYE 584
I++ E P L HLCRL++R+ +G ++ ++ LPLP + RY+ ++
Sbjct: 525 PEIRQILENPCSLKHLCRLKIRRLMGLQKLCQPASVEKLPLPPAIQRYILFK 576
Score = 93.2 bits (230), Expect = 6e-19
Identities = 74/262 (28%), Positives = 119/262 (45%), Gaps = 20/262 (7%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL+ A+K G + + T+IK +L +P + W +HEAA G+ + +L + + G +
Sbjct: 147 PLLIAVKKGSYDMVSTLIKHNTSLDQPCVKRWSAMHEAAKQGRKDIVALLLK-HGGNVHL 205
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
R T + +A GH D L L+ G + + L++A N + + +L+++
Sbjct: 206 RDGFGVTPLGVAAEYGHCDVLEHLIHKGGDVLALADDGASVLFEAAGGGNPDCISLLLEY 265
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAY---GITPLFVAAQSGQL 236
N G +H + ++ L+ V SKNA G+TP+ AA
Sbjct: 266 GGSGNVPNRAGHLPIHRAAYEGHYLALKYLI----PVTSKNAIRKSGLTPIHSAADGQNA 321
Query: 237 EALRFLAKYGADINTQASDNAS---------ALYEACKNEHEEVVEFLLSQGADANKTNK 287
+ L L + G D+NT +D+ S ALY N E LL+ GAD N
Sbjct: 322 QCLELLIENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGAD---PNL 378
Query: 288 DGLLPLHIASKKGNYRIVQMLL 309
D L L +A + NY IV++LL
Sbjct: 379 DPLNCLLVAVRANNYEIVRLLL 400
Score = 60.5 bits (145), Expect = 4e-09
Identities = 50/202 (24%), Positives = 86/202 (42%), Gaps = 47/202 (23%)
Query: 58 ADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTI 117
A L +A G+ + + +++ G + PN+ G LP+H AAY G
Sbjct: 244 ASVLFEAAGGGNPDCISLLLEYGGSGNVPNRAGHLPIHRAAYEGH--------------- 288
Query: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
YLA L L + KS TP++ A + +NA+ +++L+
Sbjct: 289 -----------YLA---------LKYLIPVTSKNAIRKSGLTPIHSAADGQNAQCLELLI 328
Query: 178 QHNADTNHRC---------NRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLF 228
++ D N + TAL+ VS ND+ ++L++ GA N + L
Sbjct: 329 ENGFDVNTLLADHISQSYDDERKTALYFGVSNNDVHCTEVLLAAGA---DPNLDPLNCLL 385
Query: 229 VAAQSGQLEALRFLAKYGADIN 250
VA ++ E +R L +GA++N
Sbjct: 386 VAVRANNYEIVRLLLSHGANVN 407
>gi|218505706 ankyrin repeat and SOCS box-containing 14 isoform 1
[Homo sapiens]
Length = 423
Score = 282 bits (722), Expect = 5e-76
Identities = 152/413 (36%), Positives = 240/413 (58%), Gaps = 10/413 (2%)
Query: 175 ILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSG 234
+L+ + AD N RC TALHE+ +++++++ GA + ++ YG TPL +AAQSG
Sbjct: 4 LLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSG 63
Query: 235 QLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLH 294
E + L + GA+ + QASD++S L EA + + V LL GADAN G LP+H
Sbjct: 64 HTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIH 123
Query: 295 IASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPE 354
+A+ +G+ +++L+PVT I++SG+SP+H AA H + LE L+ A FDVN L
Sbjct: 124 VAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQR 183
Query: 355 RARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLD 414
+ Y+D R SALYFAV N+++ + +LLL GA PN+D ++ L +A+R G + LLL
Sbjct: 184 INKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLR 243
Query: 415 HGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPS 474
HGAN++ + +P FP+ + + +K +L+ L++ G D E CF C +G+ HP
Sbjct: 244 HGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHP--SYTV 301
Query: 475 SRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFED 534
+ D +FCE ++ + +G ++ V+LDYV V++CS+LK +
Sbjct: 302 EGWTSTVIKD-----TKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGI 356
Query: 535 WAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLKYE 584
W+ I PR L HLCRL++RK +G+ ++ + LPLP RL Y+ Y+
Sbjct: 357 WSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYK 409
Score = 55.1 bits (131), Expect = 2e-07
Identities = 59/238 (24%), Positives = 108/238 (45%), Gaps = 20/238 (8%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A + G E ++ ++++G N + L EAA G + +L Y +
Sbjct: 55 PLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLE-YGADANI 113
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+++A RGHL L +L + +S +P++ A + + +++L+Q
Sbjct: 114 PKNSGHLPIHVAADRGHL-LALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQA 172
Query: 180 NADTN----HRCNRGW-----TALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVA 230
D N R N+ + +AL+ +VS +DL +++L+S GA N + L +A
Sbjct: 173 GFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGA---LPNQDPVNCLQIA 229
Query: 231 AQSGQLEALRFLAKYGADINTQASDN----ASALYEACKNEHEEVVEFLLSQGADANK 284
+ G E + L ++GA++N N SAL K+ E ++ LL+ G D +
Sbjct: 230 LRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQYTLKD--EVMLRMLLNYGYDTER 285
>gi|18390333 ankyrin repeat and SOCS box-containing 14 isoform 2
[Homo sapiens]
Length = 302
Score = 191 bits (485), Expect = 2e-48
Identities = 104/285 (36%), Positives = 164/285 (57%), Gaps = 10/285 (3%)
Query: 303 RIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDR 362
R +++L+PVT I++SG+SP+H AA H + LE L+ A FDVN L + Y+D
Sbjct: 11 RALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDH 70
Query: 363 RSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAY 422
R SALYFAV N+++ + +LLL GA PN+D ++ L +A+R G + LLL HGAN++ +
Sbjct: 71 RKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNYF 130
Query: 423 IATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPA 482
+P FP+ + + +K +L+ L++ G D E CF C +G+ HP +
Sbjct: 131 CRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHP--SYTVEGWTSTVI 188
Query: 483 ADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKA 542
D +FCE ++ + +G ++ V+LDYV V++CS+LK + W+ I
Sbjct: 189 KD-----TKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFIL 243
Query: 543 EPPRPLAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLKYE 584
PR L HLCRL++RK +G+ ++ + LPLP RL Y+ Y+
Sbjct: 244 TNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYK 288
Score = 45.8 bits (107), Expect = 1e-04
Identities = 43/137 (31%), Positives = 61/137 (44%), Gaps = 17/137 (12%)
Query: 223 GITPLFVAAQSGQLEALRFLAKYGADINTQASDNA---------SALYEACKNEHEEVVE 273
GI+P+ AA + L L + G D+N SALY A N V+
Sbjct: 29 GISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVK 88
Query: 274 FLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNH 333
LLS GA N+D + L IA + GNY ++ +LL + V+PLH + +
Sbjct: 89 LLLSAGA---LPNQDPVNCLQIALRMGNYELISLLLRHGANVNY-FCRVNPLHFPSALQY 144
Query: 334 ---DEV-LEALLSARFD 346
DEV L LL+ +D
Sbjct: 145 TLKDEVMLRMLLNYGYD 161
Score = 40.8 bits (94), Expect = 0.004
Identities = 40/135 (29%), Positives = 62/135 (45%), Gaps = 12/135 (8%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA---YPGTI 117
++K I ALK +I +LA + G P+H AA CL++L +A +
Sbjct: 1 MLKCILKFFLRALKILIPV-TDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFML 59
Query: 118 DQRTLQE-----ETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172
DQR + ++A+Y A L + LL AGA P N+ L A N E
Sbjct: 60 DQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALP---NQDPVNCLQIALRMGNYEL 116
Query: 173 VKILVQHNADTNHRC 187
+ +L++H A+ N+ C
Sbjct: 117 ISLLLRHGANVNYFC 131
>gi|7705831 ankyrin repeat and SOCS box-containing protein 3 isoform
a [Homo sapiens]
Length = 518
Score = 189 bits (479), Expect = 8e-48
Identities = 104/284 (36%), Positives = 177/284 (62%), Gaps = 6/284 (2%)
Query: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGT--IDQRT 121
A ++G+ + L+ ++K+G+++ + GW+P+HEAAY+ V CL++L A I +T
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMKT 76
Query: 122 LQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNA 181
+ A++LA +GH + LL+AGA+P+ + TPL+ A E + +++L+QH A
Sbjct: 77 FEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGA 136
Query: 182 DTNHRCNR-GWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
+ N + GW +LH++ + + E++++L+ GA E ++ +GITPLFVAAQ G+LE+L
Sbjct: 137 NVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLESLS 196
Query: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDG-LLPLHIASK 298
L GA++N QA D A+ L+ A + H + VE LLS GAD + N+D LP+H A++
Sbjct: 197 ILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQ 256
Query: 299 KGNYRIVQMLLPVTSRT-RIRRSGVSPLHLAAERNHDEVLEALL 341
G+ +I+ +L+P+T+R + VSP++ A H++ LE LL
Sbjct: 257 MGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 300
Score = 78.6 bits (192), Expect = 2e-14
Identities = 76/313 (24%), Positives = 130/313 (41%), Gaps = 52/313 (16%)
Query: 164 ACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYG 223
A N + ++ L++ + NRGW +HE+ N +E +Q+L++ +S Y
Sbjct: 17 AAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINA----DSSENY- 71
Query: 224 ITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN 283
I + + AL+ A H ++V+ LL GAD N
Sbjct: 72 -------------------------IKMKTFEGFCALHLAASQGHWKIVQILLEAGADPN 106
Query: 284 KTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRS--GVSPLHLAAERNHDEVLEALL 341
T + PL +A + G ++++LL + S G + LH A+ + + E+++ LL
Sbjct: 107 ATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLL 166
Query: 342 SARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLL 398
R N +D + L+ A + + +L+ GA+ N D +PL
Sbjct: 167 --RKGANK-------ECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLF 217
Query: 399 VAIRHGCLRTMQLLLDHGANIDAYIATHPTAFP---ATIMFAMKCLSLLKFLMDLGCDG- 454
+A + G + ++LLL GA+ D Y P A M K L LL L + CD
Sbjct: 218 IAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTG 277
Query: 455 ----EPCFSCLYG 463
P +S ++G
Sbjct: 278 LNKVSPVYSAVFG 290
Score = 68.9 bits (167), Expect = 1e-11
Identities = 60/224 (26%), Positives = 104/224 (46%), Gaps = 16/224 (7%)
Query: 229 VAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNK- 287
+AA+ G ++ LR L K G ++ + ++EA + E ++ L++ + N
Sbjct: 16 LAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQMLINADSSENYIKMK 75
Query: 288 --DGLLPLHIASKKGNYRIVQMLLPVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLSAR 344
+G LH+A+ +G+++IVQ+LL + +PL LA E +VL LL
Sbjct: 76 TFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHG 135
Query: 345 FDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDV---ISPLLVAI 401
+VN + ++L+ A N +LLL+ GA+ I+PL VA
Sbjct: 136 ANVNGS--------HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAA 187
Query: 402 RHGCLRTMQLLLDHGANIDAYIATHPT-AFPATIMFAMKCLSLL 444
++G L ++ +L+ GAN++ T F A KC+ LL
Sbjct: 188 QYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELL 231
Score = 68.2 bits (165), Expect = 2e-11
Identities = 56/243 (23%), Positives = 108/243 (44%), Gaps = 19/243 (7%)
Query: 55 LAPADPLIKAIKDGDEEALKTMIKEGKNL-AEPNKEGWLPLHEAAYYGQVGCLKVLQRAY 113
L PL A+++G + L+ +++ G N+ + GW LH+A++ +K+L R
Sbjct: 110 LEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 169
Query: 114 PGTIDQRTLQEE---TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNA 170
+ Q++ T +++A G L+ L L+ +GA + + TPL+ A + +
Sbjct: 170 A----NKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHT 225
Query: 171 EAVKILVQHNADTNHRCNR-GW-TALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLF 228
+ V++L+ AD + CN W +H + +++ +L+ + ++P++
Sbjct: 226 KCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVY 285
Query: 229 VAAQSGQLEALRFLAKYGADINTQA-------SDNASALYEACKNEHEEVVEFLLSQGAD 281
A G + L L + G + QA S A + C E +V LL GA
Sbjct: 286 SAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC--EFFGIVNILLKYGAQ 343
Query: 282 ANK 284
N+
Sbjct: 344 INE 346
Score = 56.2 bits (134), Expect = 8e-08
Identities = 40/144 (27%), Positives = 74/144 (51%), Gaps = 10/144 (6%)
Query: 281 DANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRS-GVSPLHLAAERNHDEVLEA 339
D + D + +A+++GN ++++ LL + + G P+H AA N E L+
Sbjct: 2 DFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHEAAYHNSVECLQM 61
Query: 340 LLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVI---SP 396
L++A N + + +E AL+ A + ++LL+ GADPN + +P
Sbjct: 62 LINADSSENYI----KMKTFEG--FCALHLAASQGHWKIVQILLEAGADPNATTLEETTP 115
Query: 397 LLVAIRHGCLRTMQLLLDHGANID 420
L +A+ +G + ++LLL HGAN++
Sbjct: 116 LFLAVENGQIDVLRLLLQHGANVN 139
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 166 bits (420), Expect = 6e-41
Identities = 107/368 (29%), Positives = 189/368 (51%), Gaps = 18/368 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A K + ++ ++K G ++ + G P+H AA+ G + + +L + + D
Sbjct: 380 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDV 438
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
++ ETA+++A G ++ + LL+ GA D + +TPL+ A E V++L+QH
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A + G+T LH S ++V +L+ GA G TPL VAA+ G L+
Sbjct: 499 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 558
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
+ L + A ++ + + L+ A ++++V LL +GA + T K+G PLHIA+KK
Sbjct: 559 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 618
Query: 300 GNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
+I LL + T I + GV+PLHLA++ H +++ LL + A +
Sbjct: 619 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-----------KGANI 667
Query: 359 YEDRRS--SALYFAVVNNNVYATELLLQHGADPNRDV---ISPLLVAIRHGCLRTMQLLL 413
+ +S ++L+ A + V ++L +HGAD + +PL+VA +G ++ + LL
Sbjct: 668 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 727
Query: 414 DHGANIDA 421
GAN++A
Sbjct: 728 KQGANVNA 735
Score = 149 bits (375), Expect = 9e-36
Identities = 109/389 (28%), Positives = 186/389 (47%), Gaps = 31/389 (7%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK-VLQRAYPGTID 118
PL A + G ++ ++ +++ G L K G PLH AA V C+K +LQ P +D
Sbjct: 281 PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP--VD 338
Query: 119 QRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178
TL TA+++A GH LL A P+ + TPL+ AC++ + +++LV+
Sbjct: 339 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 398
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
+ A G T +H + L ++ +L+ GA + N G T L +AA++GQ+E
Sbjct: 399 YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV 458
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASK 298
+R L + GA ++ +A + + L+ A + E+V+ LL A + +G PLHI+++
Sbjct: 459 VRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAR 518
Query: 299 KGNYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTP----LAP 353
+G + +LL + + + G +PLH+AA+ +V + LL R ++ L P
Sbjct: 519 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 578
Query: 354 ERARLYEDRRSSA--------------------LYFAVVNNNVYATELLLQHGADPN--- 390
+ D + A L+ A N + LL +GA+ N
Sbjct: 579 LHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 638
Query: 391 RDVISPLLVAIRHGCLRTMQLLLDHGANI 419
+ ++PL +A + G + LLLD GANI
Sbjct: 639 KQGVTPLHLASQEGHTDMVTLLLDKGANI 667
Score = 138 bits (347), Expect = 2e-32
Identities = 113/434 (26%), Positives = 208/434 (47%), Gaps = 59/434 (13%)
Query: 62 IKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRT 121
++A + G+ + + +K G ++ N+ G LH AA G VG ++ L ++D T
Sbjct: 15 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL-GRGSSVDSAT 73
Query: 122 LQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNA 181
+ TA+++A+ G + + L++ GA + +++ TPLY A + + + VK L+++ A
Sbjct: 74 KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 133
Query: 182 DTNHRCNRGWT-----------------------------ALHESVSRNDLEVMQILVSG 212
+ + G+T ALH + ++D + +L+
Sbjct: 134 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 193
Query: 213 --GAKVESK------NAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEAC 264
A V+SK G TPL +AA G + L GA ++ A + + L+ A
Sbjct: 194 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 253
Query: 265 KNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL----PVTSRTRIRRS 320
K + +V+ LL +G + +DGL PLH A++ G+ ++V++LL P+ +RT ++
Sbjct: 254 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART---KN 310
Query: 321 GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATE 380
G+SPLH+AA+ +H E ++ LL + V+ +AL+ A + T+
Sbjct: 311 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD---------YLTALHVAAHCGHYRVTK 361
Query: 381 LLLQHGADPNRDVI---SPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFA 437
LLL A+PN + +PL +A + ++ M+LL+ +GA+I A T P +
Sbjct: 362 LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITESGLTPIHVAAF 419
Query: 438 MKCLSLLKFLMDLG 451
M L+++ L+ G
Sbjct: 420 MGHLNIVLLLLQNG 433
Score = 132 bits (333), Expect = 7e-31
Identities = 110/370 (29%), Positives = 178/370 (48%), Gaps = 36/370 (9%)
Query: 68 GDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEE-- 125
G E +K ++KEG N+ ++ G+ PL+ AA + +K L +Q T E+
Sbjct: 87 GQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE---NGANQSTATEDGF 143
Query: 126 TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ--HNADT 183
T + +A +GH + LL E D K R L+ A + + ++ +L+Q HNAD
Sbjct: 144 TPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 199
Query: 184 ------NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
N G+T LH + ++ V +L++ GA V+ GITPL VA++ G
Sbjct: 200 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 259
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
++ L G I+ + D + L+ A ++ H++VVE LL +GA K+GL PLH+A+
Sbjct: 260 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 319
Query: 298 KKGNYRIVQMLL----PVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAP 353
+ + V+ LL PV + ++ LH+AA H V + LL R + N
Sbjct: 320 QGDHVECVKHLLQHKAPVDD---VTLDYLTALHVAAHCGHYRVTKLLLDKRANPN----- 371
Query: 354 ERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTMQ 410
AR + L+ A N + ELL+++GA ++P+ VA G L +
Sbjct: 372 --ARALNG--FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 427
Query: 411 LLLDHGANID 420
LLL +GA+ D
Sbjct: 428 LLLQNGASPD 437
Score = 126 bits (317), Expect = 5e-29
Identities = 101/402 (25%), Positives = 183/402 (45%), Gaps = 49/402 (12%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL---------- 109
PL A ++ + +K +++ G N + ++G+ PL A G + +L
Sbjct: 112 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 171
Query: 110 --------------------QRAYPGTIDQRTLQEETA------VYLATCRGHLDCLLSL 143
Q + + + + T +++A G+++ L
Sbjct: 172 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 231
Query: 144 LQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDL 203
L GA D + ++ TPL+ A +R N VK+L+ + + G T LH +
Sbjct: 232 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 291
Query: 204 EVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEA 263
+V+++L+ GA + ++ G++PL +AAQ +E ++ L ++ A ++ D +AL+ A
Sbjct: 292 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 351
Query: 264 CKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPV-TSRTRIRRSGV 322
H V + LL + A+ N +G PLHIA KK +++++L+ S I SG+
Sbjct: 352 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL 411
Query: 323 SPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELL 382
+P+H+AA H ++ LL +P+ + R +AL+ A V L
Sbjct: 412 TPIHVAAFMGHLNIVLLLL------QNGASPDVTNI---RGETALHMAARAGQVEVVRCL 462
Query: 383 LQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421
L++GA + R+ +PL +A R G +QLLL H A+ DA
Sbjct: 463 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 504
Score = 123 bits (309), Expect = 4e-28
Identities = 121/455 (26%), Positives = 195/455 (42%), Gaps = 64/455 (14%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A G+ ++ G + + G PLH A+ G +K+L G ID
Sbjct: 215 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR-GGQIDA 273
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+T T ++ A GH + LL+ GA K+ +PL+ A + + E VK L+QH
Sbjct: 274 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 333
Query: 180 ---------------------------------NADTNHRCNRGWTALHESVSRNDLEVM 206
A+ N R G+T LH + +N ++VM
Sbjct: 334 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 393
Query: 207 QILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKN 266
++LV GA +++ G+TP+ VAA G L + L + GA + +AL+ A +
Sbjct: 394 ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARA 453
Query: 267 EHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLP-VTSRTRIRRSGVSPL 325
EVV LL GA + ++ PLHIAS+ G IVQ+LL + +G +PL
Sbjct: 454 GQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPL 513
Query: 326 HLAAERNHDEVLEALLSARFDVN-------TPL-------APERARLYEDRRSSA----- 366
H++A +V LL A + TPL + + A+L RR++A
Sbjct: 514 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 573
Query: 367 -----LYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGAN 418
L+ A +N LLL+ GA P+ ++ +PL +A + ++ LL++GA
Sbjct: 574 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA- 632
Query: 419 IDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453
+ I T P + ++ L+D G +
Sbjct: 633 -ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 666
Score = 115 bits (287), Expect = 1e-25
Identities = 80/282 (28%), Positives = 130/282 (46%), Gaps = 6/282 (2%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYY-GQVGCLKVLQRAYPGTID 118
PL A K G + K +++ K G PLH AA+Y Q L +L++ G
Sbjct: 545 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK---GASP 601
Query: 119 QRTLQEE-TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
T + T +++A + + +LL GAE +I K TPL+ A + + + V +L+
Sbjct: 602 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 661
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
A+ + G T+LH + + + V IL GA ++ G TPL VA G ++
Sbjct: 662 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 721
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
+ FL K GA++N + + + L++A + H ++ LL GA N T +G L IA
Sbjct: 722 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781
Query: 298 KKGNYRIVQMLLPVTSRTRIRRSGVSPLH-LAAERNHDEVLE 338
+ G +V L VT + ++ H L EVL+
Sbjct: 782 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLD 823
Score = 107 bits (266), Expect = 4e-23
Identities = 99/373 (26%), Positives = 156/373 (41%), Gaps = 84/373 (22%)
Query: 124 EETAVYLATCR-GHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNAD 182
+ A +L R G+LD ++ L+ G + + N++ L+ A + + V+ L+ +
Sbjct: 9 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 68
Query: 183 TNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFL 242
+ +G TALH + EV+++LV GA + +++ G TPL++AAQ ++ +++L
Sbjct: 69 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128
Query: 243 AKYGADINTQASDNASALYEACKNEHEEVVEFLL-------------------------- 276
+ GA+ +T D + L A + H + V LL
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 188
Query: 277 -----SQGAD------ANKTNKDGLLPLHIASKKGNYRIVQMLL------PVTSRTRI-- 317
AD N+T + G PLHIA+ GN + +LL T+R I
Sbjct: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 248
Query: 318 --------------------------RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPL 351
R G++PLH AA HD+V+E LL
Sbjct: 249 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG------- 301
Query: 352 APERARLYEDRRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRT 408
AP AR S L+ A ++V + LLQH A D D ++ L VA G R
Sbjct: 302 APLLAR--TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRV 359
Query: 409 MQLLLDHGANIDA 421
+LLLD AN +A
Sbjct: 360 TKLLLDKRANPNA 372
Score = 65.1 bits (157), Expect = 2e-10
Identities = 49/168 (29%), Positives = 87/168 (51%), Gaps = 14/168 (8%)
Query: 252 QASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL-P 310
++ NAS L A ++VVE+L G D N N++GL LH+A+K+G+ +VQ LL
Sbjct: 7 KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 65
Query: 311 VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFA 370
+S + G + LH+A+ EV++ L+ ++N + LY A
Sbjct: 66 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA---------QSQNGFTPLYMA 116
Query: 371 VVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDH 415
N++ + LL++GA+ + D +PL VA++ G + + +LL++
Sbjct: 117 AQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 164
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 166 bits (420), Expect = 6e-41
Identities = 107/368 (29%), Positives = 189/368 (51%), Gaps = 18/368 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A K + ++ ++K G ++ + G P+H AA+ G + + +L + + D
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDV 459
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
++ ETA+++A G ++ + LL+ GA D + +TPL+ A E V++L+QH
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A + G+T LH S ++V +L+ GA G TPL VAA+ G L+
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
+ L + A ++ + + L+ A ++++V LL +GA + T K+G PLHIA+KK
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639
Query: 300 GNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
+I LL + T I + GV+PLHLA++ H +++ LL + A +
Sbjct: 640 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-----------KGANI 688
Query: 359 YEDRRS--SALYFAVVNNNVYATELLLQHGADPNRDV---ISPLLVAIRHGCLRTMQLLL 413
+ +S ++L+ A + V ++L +HGAD + +PL+VA +G ++ + LL
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748
Query: 414 DHGANIDA 421
GAN++A
Sbjct: 749 KQGANVNA 756
Score = 149 bits (375), Expect = 9e-36
Identities = 109/389 (28%), Positives = 186/389 (47%), Gaps = 31/389 (7%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK-VLQRAYPGTID 118
PL A + G ++ ++ +++ G L K G PLH AA V C+K +LQ P +D
Sbjct: 302 PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP--VD 359
Query: 119 QRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178
TL TA+++A GH LL A P+ + TPL+ AC++ + +++LV+
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 419
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
+ A G T +H + L ++ +L+ GA + N G T L +AA++GQ+E
Sbjct: 420 YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV 479
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASK 298
+R L + GA ++ +A + + L+ A + E+V+ LL A + +G PLHI+++
Sbjct: 480 VRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAR 539
Query: 299 KGNYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTP----LAP 353
+G + +LL + + + G +PLH+AA+ +V + LL R ++ L P
Sbjct: 540 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 599
Query: 354 ERARLYEDRRSSA--------------------LYFAVVNNNVYATELLLQHGADPN--- 390
+ D + A L+ A N + LL +GA+ N
Sbjct: 600 LHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 659
Query: 391 RDVISPLLVAIRHGCLRTMQLLLDHGANI 419
+ ++PL +A + G + LLLD GANI
Sbjct: 660 KQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Score = 138 bits (347), Expect = 2e-32
Identities = 113/434 (26%), Positives = 208/434 (47%), Gaps = 59/434 (13%)
Query: 62 IKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRT 121
++A + G+ + + +K G ++ N+ G LH AA G VG ++ L ++D T
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL-GRGSSVDSAT 94
Query: 122 LQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNA 181
+ TA+++A+ G + + L++ GA + +++ TPLY A + + + VK L+++ A
Sbjct: 95 KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154
Query: 182 DTNHRCNRGWT-----------------------------ALHESVSRNDLEVMQILVSG 212
+ + G+T ALH + ++D + +L+
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 213 --GAKVESK------NAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEAC 264
A V+SK G TPL +AA G + L GA ++ A + + L+ A
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274
Query: 265 KNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL----PVTSRTRIRRS 320
K + +V+ LL +G + +DGL PLH A++ G+ ++V++LL P+ +RT ++
Sbjct: 275 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART---KN 331
Query: 321 GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATE 380
G+SPLH+AA+ +H E ++ LL + V+ +AL+ A + T+
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD---------YLTALHVAAHCGHYRVTK 382
Query: 381 LLLQHGADPNRDVI---SPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFA 437
LLL A+PN + +PL +A + ++ M+LL+ +GA+I A T P +
Sbjct: 383 LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITESGLTPIHVAAF 440
Query: 438 MKCLSLLKFLMDLG 451
M L+++ L+ G
Sbjct: 441 MGHLNIVLLLLQNG 454
Score = 132 bits (333), Expect = 7e-31
Identities = 110/370 (29%), Positives = 178/370 (48%), Gaps = 36/370 (9%)
Query: 68 GDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEE-- 125
G E +K ++KEG N+ ++ G+ PL+ AA + +K L +Q T E+
Sbjct: 108 GQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE---NGANQSTATEDGF 164
Query: 126 TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ--HNADT 183
T + +A +GH + LL E D K R L+ A + + ++ +L+Q HNAD
Sbjct: 165 TPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 220
Query: 184 ------NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
N G+T LH + ++ V +L++ GA V+ GITPL VA++ G
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
++ L G I+ + D + L+ A ++ H++VVE LL +GA K+GL PLH+A+
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 340
Query: 298 KKGNYRIVQMLL----PVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAP 353
+ + V+ LL PV + ++ LH+AA H V + LL R + N
Sbjct: 341 QGDHVECVKHLLQHKAPVDD---VTLDYLTALHVAAHCGHYRVTKLLLDKRANPN----- 392
Query: 354 ERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTMQ 410
AR + L+ A N + ELL+++GA ++P+ VA G L +
Sbjct: 393 --ARALNG--FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448
Query: 411 LLLDHGANID 420
LLL +GA+ D
Sbjct: 449 LLLQNGASPD 458
Score = 126 bits (317), Expect = 5e-29
Identities = 101/402 (25%), Positives = 183/402 (45%), Gaps = 49/402 (12%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL---------- 109
PL A ++ + +K +++ G N + ++G+ PL A G + +L
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
Query: 110 --------------------QRAYPGTIDQRTLQEETA------VYLATCRGHLDCLLSL 143
Q + + + + T +++A G+++ L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
Query: 144 LQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDL 203
L GA D + ++ TPL+ A +R N VK+L+ + + G T LH +
Sbjct: 253 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 312
Query: 204 EVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEA 263
+V+++L+ GA + ++ G++PL +AAQ +E ++ L ++ A ++ D +AL+ A
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372
Query: 264 CKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPV-TSRTRIRRSGV 322
H V + LL + A+ N +G PLHIA KK +++++L+ S I SG+
Sbjct: 373 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL 432
Query: 323 SPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELL 382
+P+H+AA H ++ LL +P+ + R +AL+ A V L
Sbjct: 433 TPIHVAAFMGHLNIVLLLL------QNGASPDVTNI---RGETALHMAARAGQVEVVRCL 483
Query: 383 LQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421
L++GA + R+ +PL +A R G +QLLL H A+ DA
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Score = 123 bits (309), Expect = 4e-28
Identities = 121/455 (26%), Positives = 195/455 (42%), Gaps = 64/455 (14%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A G+ ++ G + + G PLH A+ G +K+L G ID
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR-GGQIDA 294
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+T T ++ A GH + LL+ GA K+ +PL+ A + + E VK L+QH
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 180 ---------------------------------NADTNHRCNRGWTALHESVSRNDLEVM 206
A+ N R G+T LH + +N ++VM
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414
Query: 207 QILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKN 266
++LV GA +++ G+TP+ VAA G L + L + GA + +AL+ A +
Sbjct: 415 ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARA 474
Query: 267 EHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLP-VTSRTRIRRSGVSPL 325
EVV LL GA + ++ PLHIAS+ G IVQ+LL + +G +PL
Sbjct: 475 GQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPL 534
Query: 326 HLAAERNHDEVLEALLSARFDVN-------TPL-------APERARLYEDRRSSA----- 366
H++A +V LL A + TPL + + A+L RR++A
Sbjct: 535 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 594
Query: 367 -----LYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGAN 418
L+ A +N LLL+ GA P+ ++ +PL +A + ++ LL++GA
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA- 653
Query: 419 IDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453
+ I T P + ++ L+D G +
Sbjct: 654 -ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
Score = 115 bits (287), Expect = 1e-25
Identities = 80/282 (28%), Positives = 130/282 (46%), Gaps = 6/282 (2%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYY-GQVGCLKVLQRAYPGTID 118
PL A K G + K +++ K G PLH AA+Y Q L +L++ G
Sbjct: 566 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK---GASP 622
Query: 119 QRTLQEE-TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
T + T +++A + + +LL GAE +I K TPL+ A + + + V +L+
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
A+ + G T+LH + + + V IL GA ++ G TPL VA G ++
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
+ FL K GA++N + + + L++A + H ++ LL GA N T +G L IA
Sbjct: 743 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Query: 298 KKGNYRIVQMLLPVTSRTRIRRSGVSPLH-LAAERNHDEVLE 338
+ G +V L VT + ++ H L EVL+
Sbjct: 803 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLD 844
Score = 107 bits (266), Expect = 4e-23
Identities = 99/373 (26%), Positives = 156/373 (41%), Gaps = 84/373 (22%)
Query: 124 EETAVYLATCR-GHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNAD 182
+ A +L R G+LD ++ L+ G + + N++ L+ A + + V+ L+ +
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 183 TNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFL 242
+ +G TALH + EV+++LV GA + +++ G TPL++AAQ ++ +++L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 243 AKYGADINTQASDNASALYEACKNEHEEVVEFLL-------------------------- 276
+ GA+ +T D + L A + H + V LL
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209
Query: 277 -----SQGAD------ANKTNKDGLLPLHIASKKGNYRIVQMLL------PVTSRTRI-- 317
AD N+T + G PLHIA+ GN + +LL T+R I
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269
Query: 318 --------------------------RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPL 351
R G++PLH AA HD+V+E LL
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG------- 322
Query: 352 APERARLYEDRRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRT 408
AP AR S L+ A ++V + LLQH A D D ++ L VA G R
Sbjct: 323 APLLAR--TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRV 380
Query: 409 MQLLLDHGANIDA 421
+LLLD AN +A
Sbjct: 381 TKLLLDKRANPNA 393
Score = 65.1 bits (157), Expect = 2e-10
Identities = 49/168 (29%), Positives = 87/168 (51%), Gaps = 14/168 (8%)
Query: 252 QASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL-P 310
++ NAS L A ++VVE+L G D N N++GL LH+A+K+G+ +VQ LL
Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 311 VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFA 370
+S + G + LH+A+ EV++ L+ ++N + LY A
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA---------QSQNGFTPLYMA 137
Query: 371 VVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDH 415
N++ + LL++GA+ + D +PL VA++ G + + +LL++
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 166 bits (420), Expect = 6e-41
Identities = 107/368 (29%), Positives = 189/368 (51%), Gaps = 18/368 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A K + ++ ++K G ++ + G P+H AA+ G + + +L + + D
Sbjct: 401 PLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQN-GASPDV 459
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
++ ETA+++A G ++ + LL+ GA D + +TPL+ A E V++L+QH
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A + G+T LH S ++V +L+ GA G TPL VAA+ G L+
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
+ L + A ++ + + L+ A ++++V LL +GA + T K+G PLHIA+KK
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKK 639
Query: 300 GNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
+I LL + T I + GV+PLHLA++ H +++ LL + A +
Sbjct: 640 NQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLD-----------KGANI 688
Query: 359 YEDRRS--SALYFAVVNNNVYATELLLQHGADPNRDV---ISPLLVAIRHGCLRTMQLLL 413
+ +S ++L+ A + V ++L +HGAD + +PL+VA +G ++ + LL
Sbjct: 689 HMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLL 748
Query: 414 DHGANIDA 421
GAN++A
Sbjct: 749 KQGANVNA 756
Score = 149 bits (375), Expect = 9e-36
Identities = 109/389 (28%), Positives = 186/389 (47%), Gaps = 31/389 (7%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK-VLQRAYPGTID 118
PL A + G ++ ++ +++ G L K G PLH AA V C+K +LQ P +D
Sbjct: 302 PLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAP--VD 359
Query: 119 QRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178
TL TA+++A GH LL A P+ + TPL+ AC++ + +++LV+
Sbjct: 360 DVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVK 419
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
+ A G T +H + L ++ +L+ GA + N G T L +AA++GQ+E
Sbjct: 420 YGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEV 479
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASK 298
+R L + GA ++ +A + + L+ A + E+V+ LL A + +G PLHI+++
Sbjct: 480 VRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAR 539
Query: 299 KGNYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTP----LAP 353
+G + +LL + + + G +PLH+AA+ +V + LL R ++ L P
Sbjct: 540 EGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTP 599
Query: 354 ERARLYEDRRSSA--------------------LYFAVVNNNVYATELLLQHGADPN--- 390
+ D + A L+ A N + LL +GA+ N
Sbjct: 600 LHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVT 659
Query: 391 RDVISPLLVAIRHGCLRTMQLLLDHGANI 419
+ ++PL +A + G + LLLD GANI
Sbjct: 660 KQGVTPLHLASQEGHTDMVTLLLDKGANI 688
Score = 138 bits (347), Expect = 2e-32
Identities = 113/434 (26%), Positives = 208/434 (47%), Gaps = 59/434 (13%)
Query: 62 IKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRT 121
++A + G+ + + +K G ++ N+ G LH AA G VG ++ L ++D T
Sbjct: 36 LRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELL-GRGSSVDSAT 94
Query: 122 LQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNA 181
+ TA+++A+ G + + L++ GA + +++ TPLY A + + + VK L+++ A
Sbjct: 95 KKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGA 154
Query: 182 DTNHRCNRGWT-----------------------------ALHESVSRNDLEVMQILVSG 212
+ + G+T ALH + ++D + +L+
Sbjct: 155 NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQN 214
Query: 213 --GAKVESK------NAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEAC 264
A V+SK G TPL +AA G + L GA ++ A + + L+ A
Sbjct: 215 DHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVAS 274
Query: 265 KNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL----PVTSRTRIRRS 320
K + +V+ LL +G + +DGL PLH A++ G+ ++V++LL P+ +RT ++
Sbjct: 275 KRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLART---KN 331
Query: 321 GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATE 380
G+SPLH+AA+ +H E ++ LL + V+ +AL+ A + T+
Sbjct: 332 GLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLD---------YLTALHVAAHCGHYRVTK 382
Query: 381 LLLQHGADPNRDVI---SPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFA 437
LLL A+PN + +PL +A + ++ M+LL+ +GA+I A T P +
Sbjct: 383 LLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQA--ITESGLTPIHVAAF 440
Query: 438 MKCLSLLKFLMDLG 451
M L+++ L+ G
Sbjct: 441 MGHLNIVLLLLQNG 454
Score = 132 bits (333), Expect = 7e-31
Identities = 110/370 (29%), Positives = 178/370 (48%), Gaps = 36/370 (9%)
Query: 68 GDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEE-- 125
G E +K ++KEG N+ ++ G+ PL+ AA + +K L +Q T E+
Sbjct: 108 GQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLE---NGANQSTATEDGF 164
Query: 126 TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ--HNADT 183
T + +A +GH + LL E D K R L+ A + + ++ +L+Q HNAD
Sbjct: 165 TPLAVALQQGHNQAVAILL----ENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 220
Query: 184 ------NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
N G+T LH + ++ V +L++ GA V+ GITPL VA++ G
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTN 280
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
++ L G I+ + D + L+ A ++ H++VVE LL +GA K+GL PLH+A+
Sbjct: 281 MVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAA 340
Query: 298 KKGNYRIVQMLL----PVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAP 353
+ + V+ LL PV + ++ LH+AA H V + LL R + N
Sbjct: 341 QGDHVECVKHLLQHKAPVDD---VTLDYLTALHVAAHCGHYRVTKLLLDKRANPN----- 392
Query: 354 ERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTMQ 410
AR + L+ A N + ELL+++GA ++P+ VA G L +
Sbjct: 393 --ARALNG--FTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448
Query: 411 LLLDHGANID 420
LLL +GA+ D
Sbjct: 449 LLLQNGASPD 458
Score = 126 bits (317), Expect = 5e-29
Identities = 101/402 (25%), Positives = 183/402 (45%), Gaps = 49/402 (12%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL---------- 109
PL A ++ + +K +++ G N + ++G+ PL A G + +L
Sbjct: 133 PLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVR 192
Query: 110 --------------------QRAYPGTIDQRTLQEETA------VYLATCRGHLDCLLSL 143
Q + + + + T +++A G+++ L
Sbjct: 193 LPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLL 252
Query: 144 LQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDL 203
L GA D + ++ TPL+ A +R N VK+L+ + + G T LH +
Sbjct: 253 LNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHD 312
Query: 204 EVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEA 263
+V+++L+ GA + ++ G++PL +AAQ +E ++ L ++ A ++ D +AL+ A
Sbjct: 313 QVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372
Query: 264 CKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPV-TSRTRIRRSGV 322
H V + LL + A+ N +G PLHIA KK +++++L+ S I SG+
Sbjct: 373 AHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGL 432
Query: 323 SPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELL 382
+P+H+AA H ++ LL +P+ + R +AL+ A V L
Sbjct: 433 TPIHVAAFMGHLNIVLLLL------QNGASPDVTNI---RGETALHMAARAGQVEVVRCL 483
Query: 383 LQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421
L++GA + R+ +PL +A R G +QLLL H A+ DA
Sbjct: 484 LRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Score = 123 bits (309), Expect = 4e-28
Identities = 121/455 (26%), Positives = 195/455 (42%), Gaps = 64/455 (14%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A G+ ++ G + + G PLH A+ G +K+L G ID
Sbjct: 236 PLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDR-GGQIDA 294
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+T T ++ A GH + LL+ GA K+ +PL+ A + + E VK L+QH
Sbjct: 295 KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQH 354
Query: 180 ---------------------------------NADTNHRCNRGWTALHESVSRNDLEVM 206
A+ N R G+T LH + +N ++VM
Sbjct: 355 KAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVM 414
Query: 207 QILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKN 266
++LV GA +++ G+TP+ VAA G L + L + GA + +AL+ A +
Sbjct: 415 ELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARA 474
Query: 267 EHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLP-VTSRTRIRRSGVSPL 325
EVV LL GA + ++ PLHIAS+ G IVQ+LL + +G +PL
Sbjct: 475 GQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPL 534
Query: 326 HLAAERNHDEVLEALLSARFDVN-------TPL-------APERARLYEDRRSSA----- 366
H++A +V LL A + TPL + + A+L RR++A
Sbjct: 535 HISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK 594
Query: 367 -----LYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGAN 418
L+ A +N LLL+ GA P+ ++ +PL +A + ++ LL++GA
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA- 653
Query: 419 IDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453
+ I T P + ++ L+D G +
Sbjct: 654 -ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGAN 687
Score = 115 bits (287), Expect = 1e-25
Identities = 80/282 (28%), Positives = 130/282 (46%), Gaps = 6/282 (2%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYY-GQVGCLKVLQRAYPGTID 118
PL A K G + K +++ K G PLH AA+Y Q L +L++ G
Sbjct: 566 PLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEK---GASP 622
Query: 119 QRTLQEE-TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
T + T +++A + + +LL GAE +I K TPL+ A + + + V +L+
Sbjct: 623 HATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLL 682
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
A+ + G T+LH + + + V IL GA ++ G TPL VA G ++
Sbjct: 683 DKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVK 742
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
+ FL K GA++N + + + L++A + H ++ LL GA N T +G L IA
Sbjct: 743 MVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802
Query: 298 KKGNYRIVQMLLPVTSRTRIRRSGVSPLH-LAAERNHDEVLE 338
+ G +V L VT + ++ H L EVL+
Sbjct: 803 RLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLD 844
Score = 107 bits (266), Expect = 4e-23
Identities = 99/373 (26%), Positives = 156/373 (41%), Gaps = 84/373 (22%)
Query: 124 EETAVYLATCR-GHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNAD 182
+ A +L R G+LD ++ L+ G + + N++ L+ A + + V+ L+ +
Sbjct: 30 DSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSS 89
Query: 183 TNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFL 242
+ +G TALH + EV+++LV GA + +++ G TPL++AAQ ++ +++L
Sbjct: 90 VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149
Query: 243 AKYGADINTQASDNASALYEACKNEHEEVVEFLL-------------------------- 276
+ GA+ +T D + L A + H + V LL
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209
Query: 277 -----SQGAD------ANKTNKDGLLPLHIASKKGNYRIVQMLL------PVTSRTRI-- 317
AD N+T + G PLHIA+ GN + +LL T+R I
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269
Query: 318 --------------------------RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPL 351
R G++PLH AA HD+V+E LL
Sbjct: 270 LHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERG------- 322
Query: 352 APERARLYEDRRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRT 408
AP AR S L+ A ++V + LLQH A D D ++ L VA G R
Sbjct: 323 APLLAR--TKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRV 380
Query: 409 MQLLLDHGANIDA 421
+LLLD AN +A
Sbjct: 381 TKLLLDKRANPNA 393
Score = 65.1 bits (157), Expect = 2e-10
Identities = 49/168 (29%), Positives = 87/168 (51%), Gaps = 14/168 (8%)
Query: 252 QASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL-P 310
++ NAS L A ++VVE+L G D N N++GL LH+A+K+G+ +VQ LL
Sbjct: 28 KSDSNASFLRAARAGNLDKVVEYLKG-GIDINTCNQNGLNALHLAAKEGHVGLVQELLGR 86
Query: 311 VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFA 370
+S + G + LH+A+ EV++ L+ ++N + LY A
Sbjct: 87 GSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA---------QSQNGFTPLYMA 137
Query: 371 VVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDH 415
N++ + LL++GA+ + D +PL VA++ G + + +LL++
Sbjct: 138 AQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLEN 185
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 152 bits (383), Expect = 1e-36
Identities = 106/368 (28%), Positives = 171/368 (46%), Gaps = 18/368 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQR--AYPGTI 117
PL A K + ++ ++K G ++ + G P+H AA+ G V + L A P T
Sbjct: 403 PLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTT 462
Query: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
+ R ETA+++A G + + L+Q GA+ + K +TPL+ + A+ V+ L+
Sbjct: 463 NVRG---ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
Q A N G+T LH S +V L+ GA + G TPL VAA+ G+LE
Sbjct: 520 QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLE 579
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
L + A + + L+ A ++++V LL QGA + K+G PLHIA+
Sbjct: 580 VANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAA 639
Query: 298 KKGNYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERA 356
KK I LL + R G++ +HLAA+ H +++ LL +VN
Sbjct: 640 KKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVN-------- 691
Query: 357 RLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDV---ISPLLVAIRHGCLRTMQLLL 413
L + L+ A + V E+L+ GA + +PL V +G ++ + LL
Sbjct: 692 -LSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL 750
Query: 414 DHGANIDA 421
H A ++A
Sbjct: 751 QHSAKVNA 758
Score = 149 bits (375), Expect = 9e-36
Identities = 117/401 (29%), Positives = 186/401 (46%), Gaps = 22/401 (5%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL-QRAYPGTID 118
PL A K G+ +K ++ G + ++G PLH A G +++L RA P I
Sbjct: 271 PLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAP--IL 328
Query: 119 QRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178
+T + +++AT HL+C+ LLQ D T L+ A + + K+L+
Sbjct: 329 SKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLD 388
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
A+ N + G+T LH + +N ++VM++L+ GA +++ G+TP+ VAA G +
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASK 298
+ L +GA NT +AL+ A ++ EVV +L+ GA KD PLHI+++
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
Query: 299 KGNYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALL--SARFDVNTPLAPER 355
G IVQ LL S SG +PLHL+A H++V LL A + T
Sbjct: 509 LGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITT------ 562
Query: 356 ARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLL 412
+ + L+ A + LLLQ A P+ + ++PL VA + + LL
Sbjct: 563 -----KKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLL 617
Query: 413 LDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453
LD GA+ A T P I + + L++ G D
Sbjct: 618 LDQGASPHAAAKNGYT--PLHIAAKKNQMDIATTLLEYGAD 656
Score = 138 bits (347), Expect = 2e-32
Identities = 110/427 (25%), Positives = 199/427 (46%), Gaps = 53/427 (12%)
Query: 62 IKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCL-KVLQRAYPGTIDQR 120
++A + G E IK G ++ N+ G LH A+ G V + ++LQR +D
Sbjct: 46 LRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQRE--ANVDAA 103
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
T + TA+++A+ G + + L+ GA + +++ TPLY A + + E VK L+ +
Sbjct: 104 TKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNG 163
Query: 181 ADTNHRCNRGWT-----------------------------ALHESVSRNDLEVMQILVS 211
A + G+T ALH + ++D + +L+
Sbjct: 164 ASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQ 223
Query: 212 GGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEV 271
+ ++ G TPL +AA G + L A ++ A ++ + L+ A K + +
Sbjct: 224 NDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANM 283
Query: 272 VEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL----PVTSRTRIRRSGVSPLHL 327
V+ LL +GA + +DGL PLH ++ G+ ++V+MLL P+ S+T ++G+SPLH+
Sbjct: 284 VKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKT---KNGLSPLHM 340
Query: 328 AAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGA 387
A + +H ++ LL V+ + +AL+ A + ++LL A
Sbjct: 341 ATQGDHLNCVQLLLQHNVPVDD---------VTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Query: 388 DPNRDVI---SPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLL 444
+PN + +PL +A + ++ M+LLL HGA+I A T P + M ++++
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA--VTESGLTPIHVAAFMGHVNIV 449
Query: 445 KFLMDLG 451
LM G
Sbjct: 450 SQLMHHG 456
Score = 136 bits (342), Expect = 6e-32
Identities = 96/358 (26%), Positives = 169/358 (47%), Gaps = 14/358 (3%)
Query: 68 GDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETA 127
G + K ++ + N G+ PLH A ++ +++L + + +I T T
Sbjct: 378 GHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLK-HGASIQAVTESGLTP 436
Query: 128 VYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRC 187
+++A GH++ + L+ GA P+ +N ET L+ A AE V+ LVQ A +
Sbjct: 437 IHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKA 496
Query: 188 NRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGA 247
T LH S +++Q L+ GA + G TPL ++A+ G + FL +GA
Sbjct: 497 KDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGA 556
Query: 248 DINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQM 307
++ + L+ A K EV LL + A + K GL PLH+A+ N ++ +
Sbjct: 557 SLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALL 616
Query: 308 LLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSA 366
LL S ++G +PLH+AA++N ++ LL D N A R + ++
Sbjct: 617 LLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADAN---AVTRQGI------AS 667
Query: 367 LYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421
++ A +V LLL A+ N+ ++PL +A + + ++L++ GA++DA
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDA 725
Score = 129 bits (324), Expect = 7e-30
Identities = 89/342 (26%), Positives = 159/342 (46%), Gaps = 15/342 (4%)
Query: 52 TSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL-- 109
T+ + L A + G E ++ ++++G + K+ PLH +A G+ ++ L
Sbjct: 461 TTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQ 520
Query: 110 QRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKN 169
Q A P T T ++L+ GH D LL GA I+ K TPL+ A +
Sbjct: 521 QGASPNAA---TTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGK 577
Query: 170 AEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFV 229
E +L+Q +A + G T LH + ++ +V +L+ GA + G TPL +
Sbjct: 578 LEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHI 637
Query: 230 AAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDG 289
AA+ Q++ L +YGAD N ++++ A + H ++V LL + A+ N +NK G
Sbjct: 638 AAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
Query: 290 LLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEALLSARFDVN 348
L PLH+A+++ + ++L+ + + + G +PLH+ + +++ LL VN
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVN 757
Query: 349 TPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN 390
L++ A + + +LLQ+ A PN
Sbjct: 758 AKTKNGYTPLHQ---------AAQQGHTHIINVLLQNNASPN 790
Score = 124 bits (311), Expect = 2e-28
Identities = 94/362 (25%), Positives = 160/362 (44%), Gaps = 47/362 (12%)
Query: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQ 123
A + D +A +++ N +K G+ PLH AA+YG + +L
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLL-------------- 254
Query: 124 EETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT 183
L A D + ++ TPL+ A +R NA VK+L+ A
Sbjct: 255 --------------------LNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKI 294
Query: 184 NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLA 243
+ + G T LH +V+++L+ A + SK G++PL +A Q L ++ L
Sbjct: 295 DAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLL 354
Query: 244 KYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYR 303
++ ++ +D +AL+ A H +V + LL + A+ N +G PLHIA KK +
Sbjct: 355 QHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIK 414
Query: 304 IVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDR 362
++++LL S + SG++P+H+AA H ++ L+ NT R
Sbjct: 415 VMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTT---------NVR 465
Query: 363 RSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANI 419
+AL+ A + L+Q GA +D +PL ++ R G +Q LL GA+
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525
Query: 420 DA 421
+A
Sbjct: 526 NA 527
Score = 122 bits (306), Expect = 9e-28
Identities = 93/308 (30%), Positives = 150/308 (48%), Gaps = 20/308 (6%)
Query: 118 DQRTLQEETAVYLATCR-GHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKIL 176
D++ + A YL R GHL+ L ++ G + +I N++ L+ A + + E V L
Sbjct: 34 DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
Query: 177 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQL 236
+Q A+ + +G TALH + EV+++LV+ GA V +++ G TPL++AAQ L
Sbjct: 94 LQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHL 153
Query: 237 EALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLP-LHI 295
E ++FL GA + D + L A + H++VV LL N T LP LHI
Sbjct: 154 EVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLE-----NDTKGKVRLPALHI 208
Query: 296 ASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPE 354
A++K + + +LL + + +SG +PLH+AA + V LL+ V+ +
Sbjct: 209 AARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARND 268
Query: 355 RARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTMQL 411
+ L+ A N +LLL GA RD ++PL R G + +++
Sbjct: 269 ---------ITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEM 319
Query: 412 LLDHGANI 419
LLD A I
Sbjct: 320 LLDRAAPI 327
Score = 112 bits (280), Expect = 9e-25
Identities = 83/275 (30%), Positives = 135/275 (49%), Gaps = 16/275 (5%)
Query: 151 DISNKSRETPLY-KACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQIL 209
D KS Y +A + E +++ D N G ALH + +EV+ L
Sbjct: 34 DRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSEL 93
Query: 210 VSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHE 269
+ A V++ G T L +A+ +GQ E ++ L GA++N Q+ + + LY A + H
Sbjct: 94 LQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHL 153
Query: 270 EVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAA 329
EVV+FLL GA + +DG PL +A ++G+ ++V +LL ++ ++R + LH+AA
Sbjct: 154 EVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVR---LPALHIAA 210
Query: 330 ERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADP 389
+ D+ A L + D N + + + L+ A N+ LLL A
Sbjct: 211 RK--DDTKAAALLLQNDNNADVESKSG-------FTPLHIAAHYGNINVATLLLNRAAAV 261
Query: 390 N---RDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421
+ R+ I+PL VA + G ++LLLD GA IDA
Sbjct: 262 DFTARNDITPLHVASKRGNANMVKLLLDRGAKIDA 296
Score = 107 bits (268), Expect = 2e-23
Identities = 72/281 (25%), Positives = 130/281 (46%), Gaps = 5/281 (1%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYG--QVGCLKVLQRAYPGTI 117
PL A K G E ++++ + K G PLH AA+Y +V L + Q A P
Sbjct: 568 PLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAA 627
Query: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
+ T +++A + +D +LL+ GA+ + + ++ A + + + V +L+
Sbjct: 628 AKNGY---TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
NA+ N G T LH + + + V ++LV+ GA V+++ G TPL V G ++
Sbjct: 685 GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIK 744
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
+ FL ++ A +N + + + L++A + H ++ LL A N+ +G L IA
Sbjct: 745 IVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIAR 804
Query: 298 KKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLE 338
+ G +V L VT T + + +EVL+
Sbjct: 805 RLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLD 845
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 150 bits (380), Expect = 2e-36
Identities = 109/364 (29%), Positives = 177/364 (48%), Gaps = 16/364 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A + G+ ++ ++ G + K+ PLH AA G V ++L + I
Sbjct: 275 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD-HGAPIQA 333
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+T + +++A HLDC+ LLQ AE D TPL+ A + K+L+
Sbjct: 334 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 393
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A N R G+T LH + +N + VM++L+ GA +++ G+TPL VA+ G L +
Sbjct: 394 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 453
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
+ L + GA N + L+ A + H EV ++LL A N KD PLH A++
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513
Query: 300 GNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ +V++LL + + +G +PLH+AA H E + ALL E ++
Sbjct: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE----------KEASQA 563
Query: 359 YEDRRS-SALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLD 414
++ + L+ A V ELLL+ A PN ++ ++PL VA+ H L ++LLL
Sbjct: 564 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 623
Query: 415 HGAN 418
G +
Sbjct: 624 RGGS 627
Score = 150 bits (379), Expect = 3e-36
Identities = 111/386 (28%), Positives = 187/386 (48%), Gaps = 26/386 (6%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL--QRAYPGTI 117
PL A + G E K +++ + K+ PLH AA G +K+L A P
Sbjct: 473 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 532
Query: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
T T +++A GH++ +L+LL+ A K TPL+ A + ++L+
Sbjct: 533 ---TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 589
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
+ +A N G T LH +V N+L+++++L+ G S G TPL +AA+ Q+E
Sbjct: 590 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 649
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
R L +YG N ++ + L+ A + H E+V LLS+ A+ N NK GL PLH+ +
Sbjct: 650 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 709
Query: 298 KKGNYRIVQMLLP----VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAP 353
++G+ + +L+ V + TR+ G +PLH+A+ + ++++ LL + DVN
Sbjct: 710 QEGHVPVADVLIKHGVMVDATTRM---GYTPLHVASHYGNIKLVKFLLQHQADVNA---- 762
Query: 354 ERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNR---DVISPLLVAIRHGCLRTMQ 410
+ +L S L+ A + LLL++GA PN D +PL +A R G +
Sbjct: 763 -KTKL----GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 817
Query: 411 LL--LDHGANIDAYIATHPTAFPATI 434
+L + + H +FP T+
Sbjct: 818 VLKVVTDETSFVLVSDKHRMSFPETV 843
Score = 139 bits (351), Expect = 6e-33
Identities = 100/367 (27%), Positives = 174/367 (47%), Gaps = 16/367 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK-VLQRAYPGTID 118
PL A K ++ ++K G ++ + G PLH A++ G + +K +LQR +
Sbjct: 407 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 466
Query: 119 QRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178
++ ET +++A GH + LLQ A+ + K +TPL+ A + VK+L++
Sbjct: 467 N--VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
+NA+ N G T LH + +E + L+ A G TPL VAA+ G++
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 584
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASK 298
L + A N + + L+ A + + ++V+ LL +G + +G PLHIA+K
Sbjct: 585 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 644
Query: 299 KGNYRIVQMLLPVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
+ + + LL GV+PLHLAA+ H E++ LLS + + N
Sbjct: 645 QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN--------- 695
Query: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRTMQLLLD 414
L + L+ +V ++L++HG R +PL VA +G ++ ++ LL
Sbjct: 696 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 755
Query: 415 HGANIDA 421
H A+++A
Sbjct: 756 HQADVNA 762
Score = 128 bits (321), Expect = 2e-29
Identities = 104/395 (26%), Positives = 184/395 (46%), Gaps = 26/395 (6%)
Query: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQ 123
A K+G + + ++ + L K+G LH AA GQ ++ L Y ++ ++ +
Sbjct: 85 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 143
Query: 124 EETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT 183
T +Y+A HL+ + LL+ GA +++ + TPL A ++ + V L+ +
Sbjct: 144 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 203
Query: 184 NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLA 243
R ALH + +D +L+ + + G TPL +AA L + L
Sbjct: 204 KVRL----PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 259
Query: 244 KYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYR 303
GA +N + + L+ A + + +V LL +GA KD L PLH A++ G+ R
Sbjct: 260 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 319
Query: 304 IVQMLL----PVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359
I ++LL P+ ++T+ +G+SP+H+AA+ +H + + LL +++
Sbjct: 320 ISEILLDHGAPIQAKTK---NGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHL---- 372
Query: 360 EDRRSSALYFAVVNNNVYATELLLQHGADPNRDVIS---PLLVAIRHGCLRTMQLLLDHG 416
+ L+ A + ++LL GA PN ++ PL +A + +R M+LLL G
Sbjct: 373 -----TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 427
Query: 417 ANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLG 451
A+IDA T P + M L ++K L+ G
Sbjct: 428 ASIDA--VTESGLTPLHVASFMGHLPIVKNLLQRG 460
Score = 127 bits (319), Expect = 3e-29
Identities = 101/363 (27%), Positives = 170/363 (46%), Gaps = 18/363 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A++ G E + +I G K LH AA VL + P D
Sbjct: 180 PLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNP-DV 234
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+ T +++A +L+ LL GA + + ++ TPL+ A R N V++L+
Sbjct: 235 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 294
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A + T LH + + + +IL+ GA +++K G++P+ +AAQ L+ +
Sbjct: 295 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 354
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
R L +Y A+I+ D+ + L+ A H V + LL +GA N +G PLHIA KK
Sbjct: 355 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 414
Query: 300 GNYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
+ R++++LL S + SG++PLH+A+ H +++ LL N +
Sbjct: 415 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN---------V 465
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDH 415
+ + L+ A + + LLQ+ A N +D +PL A R G ++LLL++
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 525
Query: 416 GAN 418
AN
Sbjct: 526 NAN 528
Score = 119 bits (298), Expect = 8e-27
Identities = 94/309 (30%), Positives = 149/309 (48%), Gaps = 18/309 (5%)
Query: 118 DQRTLQEETAVYLATCR-GHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKIL 176
D++ + +L R G+LD L L+ G + + N++ L+ A + + + V L
Sbjct: 38 DRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVEL 97
Query: 177 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQL 236
+ +G TALH + EV++ LV+ GA V +++ G TPL++AAQ L
Sbjct: 98 LHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHL 157
Query: 237 EALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIA 296
E ++FL + GA+ N D + L A + HE VV L++ G K L LHIA
Sbjct: 158 EVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPALHIA 213
Query: 297 SKKGNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPER 355
++ + R +LL + ++G +PLH+AA + V + LL+ VN P+
Sbjct: 214 ARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN--FTPQN 271
Query: 356 ARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTMQLL 412
+ L+ A NV LLL GA +D ++PL A R+G +R ++L
Sbjct: 272 G-------ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324
Query: 413 LDHGANIDA 421
LDHGA I A
Sbjct: 325 LDHGAPIQA 333
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 150 bits (380), Expect = 2e-36
Identities = 109/364 (29%), Positives = 177/364 (48%), Gaps = 16/364 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A + G+ ++ ++ G + K+ PLH AA G V ++L + I
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD-HGAPIQA 300
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+T + +++A HLDC+ LLQ AE D TPL+ A + K+L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A N R G+T LH + +N + VM++L+ GA +++ G+TPL VA+ G L +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
+ L + GA N + L+ A + H EV ++LL A N KD PLH A++
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 300 GNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ +V++LL + + +G +PLH+AA H E + ALL E ++
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE----------KEASQA 530
Query: 359 YEDRRS-SALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLD 414
++ + L+ A V ELLL+ A PN ++ ++PL VA+ H L ++LLL
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 415 HGAN 418
G +
Sbjct: 591 RGGS 594
Score = 150 bits (379), Expect = 3e-36
Identities = 111/386 (28%), Positives = 187/386 (48%), Gaps = 26/386 (6%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL--QRAYPGTI 117
PL A + G E K +++ + K+ PLH AA G +K+L A P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
T T +++A GH++ +L+LL+ A K TPL+ A + ++L+
Sbjct: 500 ---TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
+ +A N G T LH +V N+L+++++L+ G S G TPL +AA+ Q+E
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
R L +YG N ++ + L+ A + H E+V LLS+ A+ N NK GL PLH+ +
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 298 KKGNYRIVQMLLP----VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAP 353
++G+ + +L+ V + TR+ G +PLH+A+ + ++++ LL + DVN
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRM---GYTPLHVASHYGNIKLVKFLLQHQADVNA---- 729
Query: 354 ERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNR---DVISPLLVAIRHGCLRTMQ 410
+ +L S L+ A + LLL++GA PN D +PL +A R G +
Sbjct: 730 -KTKL----GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Query: 411 LL--LDHGANIDAYIATHPTAFPATI 434
+L + + H +FP T+
Sbjct: 785 VLKVVTDETSFVLVSDKHRMSFPETV 810
Score = 139 bits (351), Expect = 6e-33
Identities = 100/367 (27%), Positives = 174/367 (47%), Gaps = 16/367 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK-VLQRAYPGTID 118
PL A K ++ ++K G ++ + G PLH A++ G + +K +LQR +
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 119 QRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178
++ ET +++A GH + LLQ A+ + K +TPL+ A + VK+L++
Sbjct: 434 N--VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
+NA+ N G T LH + +E + L+ A G TPL VAA+ G++
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASK 298
L + A N + + L+ A + + ++V+ LL +G + +G PLHIA+K
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611
Query: 299 KGNYRIVQMLLPVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
+ + + LL GV+PLHLAA+ H E++ LLS + + N
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN--------- 662
Query: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRTMQLLLD 414
L + L+ +V ++L++HG R +PL VA +G ++ ++ LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 415 HGANIDA 421
H A+++A
Sbjct: 723 HQADVNA 729
Score = 128 bits (321), Expect = 2e-29
Identities = 104/395 (26%), Positives = 184/395 (46%), Gaps = 26/395 (6%)
Query: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQ 123
A K+G + + ++ + L K+G LH AA GQ ++ L Y ++ ++ +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110
Query: 124 EETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT 183
T +Y+A HL+ + LL+ GA +++ + TPL A ++ + V L+ +
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 184 NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLA 243
R ALH + +D +L+ + + G TPL +AA L + L
Sbjct: 171 KVRL----PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 244 KYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYR 303
GA +N + + L+ A + + +V LL +GA KD L PLH A++ G+ R
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 304 IVQMLL----PVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359
I ++LL P+ ++T ++G+SP+H+AA+ +H + + LL +++
Sbjct: 287 ISEILLDHGAPIQAKT---KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD------ 337
Query: 360 EDRRSSALYFAVVNNNVYATELLLQHGADPNRDVI---SPLLVAIRHGCLRTMQLLLDHG 416
+ L+ A + ++LL GA PN + +PL +A + +R M+LLL G
Sbjct: 338 ---HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 417 ANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLG 451
A+IDA T P + M L ++K L+ G
Sbjct: 395 ASIDA--VTESGLTPLHVASFMGHLPIVKNLLQRG 427
Score = 127 bits (319), Expect = 3e-29
Identities = 101/363 (27%), Positives = 170/363 (46%), Gaps = 18/363 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A++ G E + +I G K LH AA VL + P D
Sbjct: 147 PLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNP-DV 201
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+ T +++A +L+ LL GA + + ++ TPL+ A R N V++L+
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A + T LH + + + +IL+ GA +++K G++P+ +AAQ L+ +
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
R L +Y A+I+ D+ + L+ A H V + LL +GA N +G PLHIA KK
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381
Query: 300 GNYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
+ R++++LL S + SG++PLH+A+ H +++ LL N +
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN---------V 432
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDH 415
+ + L+ A + + LLQ+ A N +D +PL A R G ++LLL++
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 416 GAN 418
AN
Sbjct: 493 NAN 495
Score = 120 bits (302), Expect = 3e-27
Identities = 95/312 (30%), Positives = 149/312 (47%), Gaps = 17/312 (5%)
Query: 114 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV 173
P ++ R T+ A G+LD L L+ G + + N++ L+ A + + + V
Sbjct: 2 PYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV 61
Query: 174 KILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQS 233
L+ +G TALH + EV++ LV+ GA V +++ G TPL++AAQ
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 234 GQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPL 293
LE ++FL + GA+ N D + L A + HE VV L++ G K L L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPAL 177
Query: 294 HIASKKGNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLA 352
HIA++ + R +LL + ++G +PLH+AA + V + LL+ VN
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN--FT 235
Query: 353 PERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTM 409
P+ + L+ A NV LLL GA +D ++PL A R+G +R
Sbjct: 236 PQNG-------ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 410 QLLLDHGANIDA 421
++LLDHGA I A
Sbjct: 289 EILLDHGAPIQA 300
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 150 bits (380), Expect = 2e-36
Identities = 109/364 (29%), Positives = 177/364 (48%), Gaps = 16/364 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A + G+ ++ ++ G + K+ PLH AA G V ++L + I
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD-HGAPIQA 300
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+T + +++A HLDC+ LLQ AE D TPL+ A + K+L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A N R G+T LH + +N + VM++L+ GA +++ G+TPL VA+ G L +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
+ L + GA N + L+ A + H EV ++LL A N KD PLH A++
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 300 GNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ +V++LL + + +G +PLH+AA H E + ALL E ++
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE----------KEASQA 530
Query: 359 YEDRRS-SALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLD 414
++ + L+ A V ELLL+ A PN ++ ++PL VA+ H L ++LLL
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 415 HGAN 418
G +
Sbjct: 591 RGGS 594
Score = 150 bits (379), Expect = 3e-36
Identities = 111/386 (28%), Positives = 187/386 (48%), Gaps = 26/386 (6%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL--QRAYPGTI 117
PL A + G E K +++ + K+ PLH AA G +K+L A P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
T T +++A GH++ +L+LL+ A K TPL+ A + ++L+
Sbjct: 500 ---TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
+ +A N G T LH +V N+L+++++L+ G S G TPL +AA+ Q+E
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
R L +YG N ++ + L+ A + H E+V LLS+ A+ N NK GL PLH+ +
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 298 KKGNYRIVQMLLP----VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAP 353
++G+ + +L+ V + TR+ G +PLH+A+ + ++++ LL + DVN
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRM---GYTPLHVASHYGNIKLVKFLLQHQADVNA---- 729
Query: 354 ERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNR---DVISPLLVAIRHGCLRTMQ 410
+ +L S L+ A + LLL++GA PN D +PL +A R G +
Sbjct: 730 -KTKL----GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Query: 411 LL--LDHGANIDAYIATHPTAFPATI 434
+L + + H +FP T+
Sbjct: 785 VLKVVTDETSFVLVSDKHRMSFPETV 810
Score = 139 bits (351), Expect = 6e-33
Identities = 100/367 (27%), Positives = 174/367 (47%), Gaps = 16/367 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK-VLQRAYPGTID 118
PL A K ++ ++K G ++ + G PLH A++ G + +K +LQR +
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 119 QRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178
++ ET +++A GH + LLQ A+ + K +TPL+ A + VK+L++
Sbjct: 434 N--VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
+NA+ N G T LH + +E + L+ A G TPL VAA+ G++
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASK 298
L + A N + + L+ A + + ++V+ LL +G + +G PLHIA+K
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611
Query: 299 KGNYRIVQMLLPVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
+ + + LL GV+PLHLAA+ H E++ LLS + + N
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN--------- 662
Query: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRTMQLLLD 414
L + L+ +V ++L++HG R +PL VA +G ++ ++ LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 415 HGANIDA 421
H A+++A
Sbjct: 723 HQADVNA 729
Score = 128 bits (321), Expect = 2e-29
Identities = 104/395 (26%), Positives = 184/395 (46%), Gaps = 26/395 (6%)
Query: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQ 123
A K+G + + ++ + L K+G LH AA GQ ++ L Y ++ ++ +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110
Query: 124 EETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT 183
T +Y+A HL+ + LL+ GA +++ + TPL A ++ + V L+ +
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 184 NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLA 243
R ALH + +D +L+ + + G TPL +AA L + L
Sbjct: 171 KVRL----PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 244 KYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYR 303
GA +N + + L+ A + + +V LL +GA KD L PLH A++ G+ R
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 304 IVQMLL----PVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359
I ++LL P+ ++T ++G+SP+H+AA+ +H + + LL +++
Sbjct: 287 ISEILLDHGAPIQAKT---KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD------ 337
Query: 360 EDRRSSALYFAVVNNNVYATELLLQHGADPNRDVI---SPLLVAIRHGCLRTMQLLLDHG 416
+ L+ A + ++LL GA PN + +PL +A + +R M+LLL G
Sbjct: 338 ---HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 417 ANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLG 451
A+IDA T P + M L ++K L+ G
Sbjct: 395 ASIDA--VTESGLTPLHVASFMGHLPIVKNLLQRG 427
Score = 127 bits (319), Expect = 3e-29
Identities = 101/363 (27%), Positives = 170/363 (46%), Gaps = 18/363 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A++ G E + +I G K LH AA VL + P D
Sbjct: 147 PLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNP-DV 201
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+ T +++A +L+ LL GA + + ++ TPL+ A R N V++L+
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A + T LH + + + +IL+ GA +++K G++P+ +AAQ L+ +
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
R L +Y A+I+ D+ + L+ A H V + LL +GA N +G PLHIA KK
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381
Query: 300 GNYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
+ R++++LL S + SG++PLH+A+ H +++ LL N +
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN---------V 432
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDH 415
+ + L+ A + + LLQ+ A N +D +PL A R G ++LLL++
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 416 GAN 418
AN
Sbjct: 493 NAN 495
Score = 120 bits (302), Expect = 3e-27
Identities = 95/312 (30%), Positives = 149/312 (47%), Gaps = 17/312 (5%)
Query: 114 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV 173
P ++ R T+ A G+LD L L+ G + + N++ L+ A + + + V
Sbjct: 2 PYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV 61
Query: 174 KILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQS 233
L+ +G TALH + EV++ LV+ GA V +++ G TPL++AAQ
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 234 GQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPL 293
LE ++FL + GA+ N D + L A + HE VV L++ G K L L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPAL 177
Query: 294 HIASKKGNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLA 352
HIA++ + R +LL + ++G +PLH+AA + V + LL+ VN
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN--FT 235
Query: 353 PERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTM 409
P+ + L+ A NV LLL GA +D ++PL A R+G +R
Sbjct: 236 PQNG-------ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 410 QLLLDHGANIDA 421
++LLDHGA I A
Sbjct: 289 EILLDHGAPIQA 300
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 150 bits (380), Expect = 2e-36
Identities = 109/364 (29%), Positives = 177/364 (48%), Gaps = 16/364 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A + G+ ++ ++ G + K+ PLH AA G V ++L + I
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD-HGAPIQA 300
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+T + +++A HLDC+ LLQ AE D TPL+ A + K+L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A N R G+T LH + +N + VM++L+ GA +++ G+TPL VA+ G L +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
+ L + GA N + L+ A + H EV ++LL A N KD PLH A++
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 300 GNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ +V++LL + + +G +PLH+AA H E + ALL E ++
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE----------KEASQA 530
Query: 359 YEDRRS-SALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLD 414
++ + L+ A V ELLL+ A PN ++ ++PL VA+ H L ++LLL
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 415 HGAN 418
G +
Sbjct: 591 RGGS 594
Score = 150 bits (379), Expect = 3e-36
Identities = 111/386 (28%), Positives = 187/386 (48%), Gaps = 26/386 (6%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL--QRAYPGTI 117
PL A + G E K +++ + K+ PLH AA G +K+L A P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
T T +++A GH++ +L+LL+ A K TPL+ A + ++L+
Sbjct: 500 ---TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
+ +A N G T LH +V N+L+++++L+ G S G TPL +AA+ Q+E
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
R L +YG N ++ + L+ A + H E+V LLS+ A+ N NK GL PLH+ +
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 298 KKGNYRIVQMLLP----VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAP 353
++G+ + +L+ V + TR+ G +PLH+A+ + ++++ LL + DVN
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRM---GYTPLHVASHYGNIKLVKFLLQHQADVNA---- 729
Query: 354 ERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNR---DVISPLLVAIRHGCLRTMQ 410
+ +L S L+ A + LLL++GA PN D +PL +A R G +
Sbjct: 730 -KTKL----GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Query: 411 LL--LDHGANIDAYIATHPTAFPATI 434
+L + + H +FP T+
Sbjct: 785 VLKVVTDETSFVLVSDKHRMSFPETV 810
Score = 139 bits (351), Expect = 6e-33
Identities = 100/367 (27%), Positives = 174/367 (47%), Gaps = 16/367 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK-VLQRAYPGTID 118
PL A K ++ ++K G ++ + G PLH A++ G + +K +LQR +
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 119 QRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178
++ ET +++A GH + LLQ A+ + K +TPL+ A + VK+L++
Sbjct: 434 N--VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
+NA+ N G T LH + +E + L+ A G TPL VAA+ G++
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASK 298
L + A N + + L+ A + + ++V+ LL +G + +G PLHIA+K
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611
Query: 299 KGNYRIVQMLLPVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
+ + + LL GV+PLHLAA+ H E++ LLS + + N
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN--------- 662
Query: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRTMQLLLD 414
L + L+ +V ++L++HG R +PL VA +G ++ ++ LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 415 HGANIDA 421
H A+++A
Sbjct: 723 HQADVNA 729
Score = 128 bits (321), Expect = 2e-29
Identities = 104/395 (26%), Positives = 184/395 (46%), Gaps = 26/395 (6%)
Query: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQ 123
A K+G + + ++ + L K+G LH AA GQ ++ L Y ++ ++ +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110
Query: 124 EETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT 183
T +Y+A HL+ + LL+ GA +++ + TPL A ++ + V L+ +
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 184 NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLA 243
R ALH + +D +L+ + + G TPL +AA L + L
Sbjct: 171 KVRL----PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 244 KYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYR 303
GA +N + + L+ A + + +V LL +GA KD L PLH A++ G+ R
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 304 IVQMLL----PVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359
I ++LL P+ ++T ++G+SP+H+AA+ +H + + LL +++
Sbjct: 287 ISEILLDHGAPIQAKT---KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD------ 337
Query: 360 EDRRSSALYFAVVNNNVYATELLLQHGADPNRDVI---SPLLVAIRHGCLRTMQLLLDHG 416
+ L+ A + ++LL GA PN + +PL +A + +R M+LLL G
Sbjct: 338 ---HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 417 ANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLG 451
A+IDA T P + M L ++K L+ G
Sbjct: 395 ASIDA--VTESGLTPLHVASFMGHLPIVKNLLQRG 427
Score = 127 bits (319), Expect = 3e-29
Identities = 101/363 (27%), Positives = 170/363 (46%), Gaps = 18/363 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A++ G E + +I G K LH AA VL + P D
Sbjct: 147 PLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNP-DV 201
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+ T +++A +L+ LL GA + + ++ TPL+ A R N V++L+
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A + T LH + + + +IL+ GA +++K G++P+ +AAQ L+ +
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
R L +Y A+I+ D+ + L+ A H V + LL +GA N +G PLHIA KK
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381
Query: 300 GNYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
+ R++++LL S + SG++PLH+A+ H +++ LL N +
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN---------V 432
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDH 415
+ + L+ A + + LLQ+ A N +D +PL A R G ++LLL++
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 416 GAN 418
AN
Sbjct: 493 NAN 495
Score = 120 bits (302), Expect = 3e-27
Identities = 95/312 (30%), Positives = 149/312 (47%), Gaps = 17/312 (5%)
Query: 114 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV 173
P ++ R T+ A G+LD L L+ G + + N++ L+ A + + + V
Sbjct: 2 PYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV 61
Query: 174 KILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQS 233
L+ +G TALH + EV++ LV+ GA V +++ G TPL++AAQ
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 234 GQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPL 293
LE ++FL + GA+ N D + L A + HE VV L++ G K L L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPAL 177
Query: 294 HIASKKGNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLA 352
HIA++ + R +LL + ++G +PLH+AA + V + LL+ VN
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN--FT 235
Query: 353 PERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTM 409
P+ + L+ A NV LLL GA +D ++PL A R+G +R
Sbjct: 236 PQNG-------ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 410 QLLLDHGANIDA 421
++LLDHGA I A
Sbjct: 289 EILLDHGAPIQA 300
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 150 bits (380), Expect = 2e-36
Identities = 109/364 (29%), Positives = 177/364 (48%), Gaps = 16/364 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A + G+ ++ ++ G + K+ PLH AA G V ++L + I
Sbjct: 242 PLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD-HGAPIQA 300
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+T + +++A HLDC+ LLQ AE D TPL+ A + K+L+
Sbjct: 301 KTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDK 360
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A N R G+T LH + +N + VM++L+ GA +++ G+TPL VA+ G L +
Sbjct: 361 GAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIV 420
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
+ L + GA N + L+ A + H EV ++LL A N KD PLH A++
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 300 GNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ +V++LL + + +G +PLH+AA H E + ALL E ++
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLE----------KEASQA 530
Query: 359 YEDRRS-SALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLD 414
++ + L+ A V ELLL+ A PN ++ ++PL VA+ H L ++LLL
Sbjct: 531 CMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLP 590
Query: 415 HGAN 418
G +
Sbjct: 591 RGGS 594
Score = 150 bits (379), Expect = 3e-36
Identities = 111/386 (28%), Positives = 187/386 (48%), Gaps = 26/386 (6%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL--QRAYPGTI 117
PL A + G E K +++ + K+ PLH AA G +K+L A P
Sbjct: 440 PLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLA 499
Query: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
T T +++A GH++ +L+LL+ A K TPL+ A + ++L+
Sbjct: 500 ---TTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLL 556
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
+ +A N G T LH +V N+L+++++L+ G S G TPL +AA+ Q+E
Sbjct: 557 ERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVE 616
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
R L +YG N ++ + L+ A + H E+V LLS+ A+ N NK GL PLH+ +
Sbjct: 617 VARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVA 676
Query: 298 KKGNYRIVQMLLP----VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAP 353
++G+ + +L+ V + TR+ G +PLH+A+ + ++++ LL + DVN
Sbjct: 677 QEGHVPVADVLIKHGVMVDATTRM---GYTPLHVASHYGNIKLVKFLLQHQADVNA---- 729
Query: 354 ERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNR---DVISPLLVAIRHGCLRTMQ 410
+ +L S L+ A + LLL++GA PN D +PL +A R G +
Sbjct: 730 -KTKL----GYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTD 784
Query: 411 LL--LDHGANIDAYIATHPTAFPATI 434
+L + + H +FP T+
Sbjct: 785 VLKVVTDETSFVLVSDKHRMSFPETV 810
Score = 139 bits (351), Expect = 6e-33
Identities = 100/367 (27%), Positives = 174/367 (47%), Gaps = 16/367 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK-VLQRAYPGTID 118
PL A K ++ ++K G ++ + G PLH A++ G + +K +LQR +
Sbjct: 374 PLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVS 433
Query: 119 QRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178
++ ET +++A GH + LLQ A+ + K +TPL+ A + VK+L++
Sbjct: 434 N--VKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
+NA+ N G T LH + +E + L+ A G TPL VAA+ G++
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASK 298
L + A N + + L+ A + + ++V+ LL +G + +G PLHIA+K
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611
Query: 299 KGNYRIVQMLLPVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
+ + + LL GV+PLHLAA+ H E++ LLS + + N
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGN--------- 662
Query: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGA---DPNRDVISPLLVAIRHGCLRTMQLLLD 414
L + L+ +V ++L++HG R +PL VA +G ++ ++ LL
Sbjct: 663 LGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQ 722
Query: 415 HGANIDA 421
H A+++A
Sbjct: 723 HQADVNA 729
Score = 128 bits (321), Expect = 2e-29
Identities = 104/395 (26%), Positives = 184/395 (46%), Gaps = 26/395 (6%)
Query: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQ 123
A K+G + + ++ + L K+G LH AA GQ ++ L Y ++ ++ +
Sbjct: 52 ASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVN-YGANVNAQSQK 110
Query: 124 EETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT 183
T +Y+A HL+ + LL+ GA +++ + TPL A ++ + V L+ +
Sbjct: 111 GFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKG 170
Query: 184 NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLA 243
R ALH + +D +L+ + + G TPL +AA L + L
Sbjct: 171 KVRL----PALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLL 226
Query: 244 KYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYR 303
GA +N + + L+ A + + +V LL +GA KD L PLH A++ G+ R
Sbjct: 227 NRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVR 286
Query: 304 IVQMLL----PVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359
I ++LL P+ ++T ++G+SP+H+AA+ +H + + LL +++
Sbjct: 287 ISEILLDHGAPIQAKT---KNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLD------ 337
Query: 360 EDRRSSALYFAVVNNNVYATELLLQHGADPNRDVI---SPLLVAIRHGCLRTMQLLLDHG 416
+ L+ A + ++LL GA PN + +PL +A + +R M+LLL G
Sbjct: 338 ---HLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTG 394
Query: 417 ANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLG 451
A+IDA T P + M L ++K L+ G
Sbjct: 395 ASIDA--VTESGLTPLHVASFMGHLPIVKNLLQRG 427
Score = 127 bits (319), Expect = 3e-29
Identities = 101/363 (27%), Positives = 170/363 (46%), Gaps = 18/363 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A++ G E + +I G K LH AA VL + P D
Sbjct: 147 PLAVALQQGHENVVAHLINYGTK----GKVRLPALHIAARNDDTRTAAVLLQNDPNP-DV 201
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+ T +++A +L+ LL GA + + ++ TPL+ A R N V++L+
Sbjct: 202 LSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDR 261
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A + T LH + + + +IL+ GA +++K G++P+ +AAQ L+ +
Sbjct: 262 GAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
R L +Y A+I+ D+ + L+ A H V + LL +GA N +G PLHIA KK
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKK 381
Query: 300 GNYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
+ R++++LL S + SG++PLH+A+ H +++ LL N +
Sbjct: 382 NHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN---------V 432
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDH 415
+ + L+ A + + LLQ+ A N +D +PL A R G ++LLL++
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492
Query: 416 GAN 418
AN
Sbjct: 493 NAN 495
Score = 120 bits (302), Expect = 3e-27
Identities = 95/312 (30%), Positives = 149/312 (47%), Gaps = 17/312 (5%)
Query: 114 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV 173
P ++ R T+ A G+LD L L+ G + + N++ L+ A + + + V
Sbjct: 2 PYSVGFREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMV 61
Query: 174 KILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQS 233
L+ +G TALH + EV++ LV+ GA V +++ G TPL++AAQ
Sbjct: 62 VELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQE 121
Query: 234 GQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPL 293
LE ++FL + GA+ N D + L A + HE VV L++ G K L L
Sbjct: 122 NHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGT----KGKVRLPAL 177
Query: 294 HIASKKGNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLA 352
HIA++ + R +LL + ++G +PLH+AA + V + LL+ VN
Sbjct: 178 HIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN--FT 235
Query: 353 PERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTM 409
P+ + L+ A NV LLL GA +D ++PL A R+G +R
Sbjct: 236 PQNG-------ITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRIS 288
Query: 410 QLLLDHGANIDA 421
++LLDHGA I A
Sbjct: 289 EILLDHGAPIQA 300
>gi|22208951 ankyrin repeat and SOCS box-containing protein 3
isoform b [Homo sapiens]
Length = 445
Score = 150 bits (380), Expect = 2e-36
Identities = 85/226 (37%), Positives = 141/226 (62%), Gaps = 4/226 (1%)
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+T + A++LA +GH + LL+AGA+P+ + TPL+ A E + +++L+QH
Sbjct: 2 KTFEGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQH 61
Query: 180 NADTNHRCNR-GWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
A+ N + GW +LH++ + + E++++L+ GA E ++ +GITPLFVAAQ G+LE+
Sbjct: 62 GANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQYGKLES 121
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDG-LLPLHIA 296
L L GA++N QA D A+ L+ A + H + VE LLS GAD + N+D LP+H A
Sbjct: 122 LSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIHAA 181
Query: 297 SKKGNYRIVQMLLPVTSRT-RIRRSGVSPLHLAAERNHDEVLEALL 341
++ G+ +I+ +L+P+T+R + VSP++ A H++ LE LL
Sbjct: 182 AQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFGGHEDCLEILL 227
Score = 68.2 bits (165), Expect = 2e-11
Identities = 56/243 (23%), Positives = 108/243 (44%), Gaps = 19/243 (7%)
Query: 55 LAPADPLIKAIKDGDEEALKTMIKEGKNL-AEPNKEGWLPLHEAAYYGQVGCLKVLQRAY 113
L PL A+++G + L+ +++ G N+ + GW LH+A++ +K+L R
Sbjct: 37 LEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCGWNSLHQASFQENAEIIKLLLRKG 96
Query: 114 PGTIDQRTLQEE---TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNA 170
+ Q++ T +++A G L+ L L+ +GA + + TPL+ A + +
Sbjct: 97 A----NKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHT 152
Query: 171 EAVKILVQHNADTNHRCNR-GW-TALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLF 228
+ V++L+ AD + CN W +H + +++ +L+ + ++P++
Sbjct: 153 KCVELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVY 212
Query: 229 VAAQSGQLEALRFLAKYGADINTQA-------SDNASALYEACKNEHEEVVEFLLSQGAD 281
A G + L L + G + QA S A + C E +V LL GA
Sbjct: 213 SAVFGGHEDCLEILLRNGYSPDAQACLVFGFSSPVCMAFQKDC--EFFGIVNILLKYGAQ 270
Query: 282 ANK 284
N+
Sbjct: 271 INE 273
Score = 65.5 bits (158), Expect = 1e-10
Identities = 60/218 (27%), Positives = 98/218 (44%), Gaps = 22/218 (10%)
Query: 259 ALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR 318
AL+ A H ++V+ LL GAD N T + PL +A + G ++++LL +
Sbjct: 9 ALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGANVNGS 68
Query: 319 RS--GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNV 376
S G + LH A+ + + E+++ LL R N +D + L+ A +
Sbjct: 69 HSMCGWNSLHQASFQENAEIIKLLL--RKGANK-------ECQDDFGITPLFVAAQYGKL 119
Query: 377 YATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFP-- 431
+ +L+ GA+ N D +PL +A + G + ++LLL GA+ D Y P
Sbjct: 120 ESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDSWQLPIH 179
Query: 432 -ATIMFAMKCLSLLKFLMDLGCDG-----EPCFSCLYG 463
A M K L LL L + CD P +S ++G
Sbjct: 180 AAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSAVFG 217
Score = 53.9 bits (128), Expect = 4e-07
Identities = 47/162 (29%), Positives = 76/162 (46%), Gaps = 13/162 (8%)
Query: 288 DGLLPLHIASKKGNYRIVQMLLPVTSRTRIRR-SGVSPLHLAAERNHDEVLEALLSARFD 346
+G LH+A+ +G+++IVQ+LL + +PL LA E +VL LL +
Sbjct: 5 EGFCALHLAASQGHWKIVQILLEAGADPNATTLEETTPLFLAVENGQIDVLRLLLQHGAN 64
Query: 347 VNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDV---ISPLLVAIRH 403
VN + ++L+ A N +LLL+ GA+ I+PL VA ++
Sbjct: 65 VNGS--------HSMCGWNSLHQASFQENAEIIKLLLRKGANKECQDDFGITPLFVAAQY 116
Query: 404 GCLRTMQLLLDHGANIDAYIATHPT-AFPATIMFAMKCLSLL 444
G L ++ +L+ GAN++ T F A KC+ LL
Sbjct: 117 GKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKCVELL 158
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 140 bits (353), Expect = 3e-33
Identities = 106/365 (29%), Positives = 181/365 (49%), Gaps = 14/365 (3%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
+I +++ + ALK ++++ K++ E N+ G PL AA G + +K L + +
Sbjct: 9 VINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKN-GANCNLE 67
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
L TA+ A+ GH+ + LL+ G + + T L AC + + V++L+ H
Sbjct: 68 DLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHG 127
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
A+ + + + R +++ +L+ GAKV + YG TPL AA+ G LE ++
Sbjct: 128 ANPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVK 187
Query: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKG 300
L GAD++ + +++ +AL A K + + V+ +L + + N T+KDG L IASK+G
Sbjct: 188 HLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEG 247
Query: 301 NYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359
+ IVQ LL + I RSG + L A H E++ ALL D++ +
Sbjct: 248 HTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADID---------IR 298
Query: 360 EDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHG 416
+ALY+AV N +LQ D +D +PL+ A + + ++LLLD G
Sbjct: 299 GQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKG 358
Query: 417 ANIDA 421
A + A
Sbjct: 359 AKVSA 363
Score = 105 bits (262), Expect = 1e-22
Identities = 90/329 (27%), Positives = 143/329 (43%), Gaps = 33/329 (10%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKV------------ 108
LI A K+G ++ ++K G NL + GW L A Y G+ +++
Sbjct: 75 LISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGANPSVTG 134
Query: 109 LQRAYP---------GTIDQRTLQE-----------ETAVYLATCRGHLDCLLSLLQAGA 148
L YP I LQ T + A +GHL+C+ LL GA
Sbjct: 135 LYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGA 194
Query: 149 EPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQI 208
+ D + T L A + ++VK +++ N + N G TAL + E++Q
Sbjct: 195 DVDQEGANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQD 254
Query: 209 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH 268
L+ G V + G T L A + G +E +R L + ADI+ + DN +ALY A + +
Sbjct: 255 LLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGN 314
Query: 269 EEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSR-TRIRRSGVSPLHL 327
+V +L D KDG PL A+K N +V++LL ++ + + + G +PLH+
Sbjct: 315 ATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHI 374
Query: 328 AAERNHDEVLEALLSARFDVNTPLAPERA 356
A ++ E LL D P +A
Sbjct: 375 AIRGRSRKLAELLLRNPKDGRLLYRPNKA 403
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 140 bits (353), Expect = 3e-33
Identities = 105/371 (28%), Positives = 174/371 (46%), Gaps = 10/371 (2%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L +A DGD A++ ++ EG+++ E +EG L A G +VL + D+
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
+ T + A+ G+LD + LL A+ + + + T L AC + VK+L+
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVES-KNAYGITPLFVAAQSGQLEAL 239
A+ G T L E+ S +EV ++L+ GA + + N + + L +A G L+ +
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
RFL + GAD + + +AL EAC + H EV LL GA N PL +A+
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
Query: 300 GNYRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ + +L+ + + G +PL AA H+E++ LL+ ++N
Sbjct: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------- 501
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN 418
E+ + +AL A + L++ GAD +PL+ A + G L ++ LL GAN
Sbjct: 502 -EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGAN 560
Query: 419 IDAYIATHPTA 429
+ A AT TA
Sbjct: 561 VHATTATGDTA 571
Score = 102 bits (255), Expect = 8e-22
Identities = 90/331 (27%), Positives = 155/331 (46%), Gaps = 14/331 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL+ A G + +K ++ ++ + G L A G V +KVL I+
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE-GANIED 333
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI-SNKSRETPLYKACERKNAEAVKILVQ 178
T + A GH++ LL GA + SN+ +E+ L AC + + + V+ L++
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
AD H+ + TAL E+ +EV ++L+ GA+V +PL +AA G +E
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDGLLPLHIAS 297
L + GA++ + + L EA + HEE+V LL+QGA+ N +T + L +A
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
Query: 298 KKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
G + L+ + + S +PL A++ H E+++ LL++ +V+ A
Sbjct: 514 CGGFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLASGANVHATTA----- 566
Query: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGAD 388
+AL +A N + ++LLQ GAD
Sbjct: 567 ----TGDTALTYACENGHTDVADVLLQAGAD 593
Score = 89.7 bits (221), Expect = 7e-18
Identities = 71/288 (24%), Positives = 118/288 (40%), Gaps = 64/288 (22%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L A G + +K ++ EG N+ + N+ G PL EAA G V +VL G
Sbjct: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKIL---- 176
+E+A+ LA +GHLD + LL+AGA+ + T L +AC + E ++L
Sbjct: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
Query: 177 -----------------------------VQHNADTNHRCNRGWTALHESVSRNDLEVMQ 207
++ A+ + G+T L E+ E++
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
Query: 208 ILVSGGAKVESKNAYG-------------------------------ITPLFVAAQSGQL 236
+L++ GA + ++ TPL A+Q G L
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHL 548
Query: 237 EALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANK 284
E +++L GA+++ + +AL AC+N H +V + LL GAD +K
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 596
Score = 67.8 bits (164), Expect = 3e-11
Identities = 52/167 (31%), Positives = 78/167 (46%), Gaps = 7/167 (4%)
Query: 57 PAD----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA 112
PAD PL A G E +I+ G NL E N EG+ PL EAA G + +L
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 113 YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172
Q +ETA+ LA C G + L++AGA+ ++ TPL +A + + E
Sbjct: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 550
Query: 173 VKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESK 219
VK L+ A+ + G TAL + +V +L+ GA ++ +
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 597
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 140 bits (353), Expect = 3e-33
Identities = 105/371 (28%), Positives = 174/371 (46%), Gaps = 10/371 (2%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L +A DGD A++ ++ EG+++ E +EG L A G +VL + D+
Sbjct: 198 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 257
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
+ T + A+ G+LD + LL A+ + + + T L AC + VK+L+
Sbjct: 258 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 317
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVES-KNAYGITPLFVAAQSGQLEAL 239
A+ G T L E+ S +EV ++L+ GA + + N + + L +A G L+ +
Sbjct: 318 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 377
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
RFL + GAD + + +AL EAC + H EV LL GA N PL +A+
Sbjct: 378 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 437
Query: 300 GNYRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ + +L+ + + G +PL AA H+E++ LL+ ++N
Sbjct: 438 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------- 490
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN 418
E+ + +AL A + L++ GAD +PL+ A + G L ++ LL GAN
Sbjct: 491 -EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGAN 549
Query: 419 IDAYIATHPTA 429
+ A AT TA
Sbjct: 550 VHATTATGDTA 560
Score = 102 bits (255), Expect = 8e-22
Identities = 90/331 (27%), Positives = 155/331 (46%), Gaps = 14/331 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL+ A G + +K ++ ++ + G L A G V +KVL I+
Sbjct: 264 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE-GANIED 322
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI-SNKSRETPLYKACERKNAEAVKILVQ 178
T + A GH++ LL GA + SN+ +E+ L AC + + + V+ L++
Sbjct: 323 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 382
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
AD H+ + TAL E+ +EV ++L+ GA+V +PL +AA G +E
Sbjct: 383 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 442
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDGLLPLHIAS 297
L + GA++ + + L EA + HEE+V LL+QGA+ N +T + L +A
Sbjct: 443 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 502
Query: 298 KKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
G + L+ + + S +PL A++ H E+++ LL++ +V+ A
Sbjct: 503 CGGFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLASGANVHATTA----- 555
Query: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGAD 388
+AL +A N + ++LLQ GAD
Sbjct: 556 ----TGDTALTYACENGHTDVADVLLQAGAD 582
Score = 89.7 bits (221), Expect = 7e-18
Identities = 71/288 (24%), Positives = 118/288 (40%), Gaps = 64/288 (22%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L A G + +K ++ EG N+ + N+ G PL EAA G V +VL G
Sbjct: 298 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 357
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKIL---- 176
+E+A+ LA +GHLD + LL+AGA+ + T L +AC + E ++L
Sbjct: 358 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 417
Query: 177 -----------------------------VQHNADTNHRCNRGWTALHESVSRNDLEVMQ 207
++ A+ + G+T L E+ E++
Sbjct: 418 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 477
Query: 208 ILVSGGAKVESKNAYG-------------------------------ITPLFVAAQSGQL 236
+L++ GA + ++ TPL A+Q G L
Sbjct: 478 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHL 537
Query: 237 EALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANK 284
E +++L GA+++ + +AL AC+N H +V + LL GAD +K
Sbjct: 538 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDK 585
Score = 67.8 bits (164), Expect = 3e-11
Identities = 52/167 (31%), Positives = 78/167 (46%), Gaps = 7/167 (4%)
Query: 57 PAD----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA 112
PAD PL A G E +I+ G NL E N EG+ PL EAA G + +L
Sbjct: 423 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 482
Query: 113 YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172
Q +ETA+ LA C G + L++AGA+ ++ TPL +A + + E
Sbjct: 483 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 539
Query: 173 VKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESK 219
VK L+ A+ + G TAL + +V +L+ GA ++ +
Sbjct: 540 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLDKQ 586
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 140 bits (353), Expect = 3e-33
Identities = 105/371 (28%), Positives = 174/371 (46%), Gaps = 10/371 (2%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L +A DGD A++ ++ EG+++ E +EG L A G +VL + D+
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
+ T + A+ G+LD + LL A+ + + + T L AC + VK+L+
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVES-KNAYGITPLFVAAQSGQLEAL 239
A+ G T L E+ S +EV ++L+ GA + + N + + L +A G L+ +
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
RFL + GAD + + +AL EAC + H EV LL GA N PL +A+
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
Query: 300 GNYRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ + +L+ + + G +PL AA H+E++ LL+ ++N
Sbjct: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------- 501
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN 418
E+ + +AL A + L++ GAD +PL+ A + G L ++ LL GAN
Sbjct: 502 -EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGAN 560
Query: 419 IDAYIATHPTA 429
+ A AT TA
Sbjct: 561 VHATTATGDTA 571
Score = 136 bits (342), Expect = 6e-32
Identities = 116/401 (28%), Positives = 176/401 (43%), Gaps = 33/401 (8%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L A G + +K ++ EG N+ + N+ G PL EAA G V +VL G
Sbjct: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
+E+A+ LA +GHLD + LL+AGA+ + T L +AC + E ++L+
Sbjct: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
A N + + L + +E+ +L+ GA +E N G TPL AA+ G E +
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
Query: 241 FLAKYGADINTQASDNA-SALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
L GA+IN Q + +AL AC EV +FL+ GAD PL AS++
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCST---PLMEASQE 545
Query: 300 GNYRIVQMLLPVTSRTRIRRS-GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ +V+ LL + + G + L A E H +V + LL A D+ R L
Sbjct: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
Query: 359 YEDRRSSALYF-------------AVVNNN------------VYATELLLQHGADPN--- 390
+ R+ L A NN+ + ELLL HGADP
Sbjct: 606 MKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRL 665
Query: 391 RDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFP 431
+D + L+ A + G + LLD+ N+ + T + P
Sbjct: 666 KDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLP 706
Score = 119 bits (299), Expect = 6e-27
Identities = 88/258 (34%), Positives = 127/258 (49%), Gaps = 8/258 (3%)
Query: 57 PAD----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA 112
PAD PL A G E +I+ G NL E N EG+ PL EAA G + +L
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 113 YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172
Q +ETA+ LA C G + L++AGA+ ++ TPL +A + + E
Sbjct: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 550
Query: 173 VKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232
VK L+ A+ + G TAL + +V +L+ GA +E ++ G TPL AA+
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 610
Query: 233 SGQLEALRFLAKYGADINTQASDNASALYE-ACKNEHEEVVEFLLSQGADANKTNKDGLL 291
+G L ++FL GA++N ++N + AC H VVE LL+ GAD KDG
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670
Query: 292 PLHIASKKGNYRIVQMLL 309
L A+K G+ +V LL
Sbjct: 671 MLIEAAKGGHTNVVSYLL 688
Score = 118 bits (295), Expect = 2e-26
Identities = 108/399 (27%), Positives = 188/399 (47%), Gaps = 18/399 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL+ A G + +K ++ ++ + G L A G V +KVL I+
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE-GANIED 333
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI-SNKSRETPLYKACERKNAEAVKILVQ 178
T + A GH++ LL GA + SN+ +E+ L AC + + + V+ L++
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
AD H+ + TAL E+ +EV ++L+ GA+V +PL +AA G +E
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDGLLPLHIAS 297
L + GA++ + + L EA + HEE+V LL+QGA+ N +T + L +A
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
Query: 298 KKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
G + L+ + + S +PL A++ H E+++ LL++ +V+ A
Sbjct: 514 CGGFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLASGANVHATTA----- 566
Query: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDV---ISPLLVAIRHGCLRTMQLLLD 414
+AL +A N + ++LLQ GAD + +PL+ A R G L T+Q L+
Sbjct: 567 ----TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622
Query: 415 HGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453
GAN++ A + ++ A L++++ L+ G D
Sbjct: 623 KGANVNRATANNDHTV-VSLACAGGHLAVVELLLAHGAD 660
Score = 112 bits (279), Expect = 1e-24
Identities = 90/309 (29%), Positives = 152/309 (49%), Gaps = 23/309 (7%)
Query: 117 IDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI-SNKSRETPLYKACERKNAEAVKI 175
I+ R + T + LA GH+ + LL G + + S ++++TPL AC E V +
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
Query: 176 LVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESK--NAYGITPLFVAAQS 233
L+ A+ HR +T L + S + +++IL++ GA++ S+ + GI+PL +AA +
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
Query: 234 GQLEALRFLAKYGADINTQASDNA-SALYEACKNEHEEVVEFLLSQGADANKTNKDGLLP 292
G + A++ L G+DIN Q N +AL AC EVV LL + A+ K GL P
Sbjct: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
Query: 293 LHIASKKGNYRIVQMLLPV---TSRTRIRRSGVSPLHLAAERNHDEVLEALL--SARFDV 347
L A+ G + ++LL + + S + L +AA++ H + E L+ A DV
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
Query: 348 NTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHG 404
+ ++ L+ A + +LL+Q GAD + I+PL+ A R G
Sbjct: 1321 R-----------NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
Query: 405 CLRTMQLLL 413
++ +Q L+
Sbjct: 1370 HVKVVQYLV 1378
Score = 111 bits (277), Expect = 2e-24
Identities = 117/404 (28%), Positives = 177/404 (43%), Gaps = 26/404 (6%)
Query: 30 PARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKE 89
P A G QG++ + L + PA L + D A+ T + G N + E
Sbjct: 964 PQIAITGHDQGLLVQEPDGLMVAT---PAQTLTDTLDDLIA-AVSTRVPTGSNSSSQTTE 1019
Query: 90 GWLPLHEAAYYGQVGCLKVLQRAYPGT-IDQRT-LQEETAVYLATCRGHLDCLLSLLQAG 147
P + V + + YP ID T +TA+ LA GH + + L+
Sbjct: 1020 CLTPESCSQTTSNVAS-QSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARD 1078
Query: 148 AEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGW-TALHESVSRNDLEVM 206
A+ + +K TPL A + V+IL+ D + R T L + S EV+
Sbjct: 1079 AKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVV 1138
Query: 207 QILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASD--NASALYEAC 264
+L++ GA E +N TPL +AA G + ++ L GA+IN++ S L A
Sbjct: 1139 DLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAA 1198
Query: 265 KNEHEEVVEFLLSQGADAN---KTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RS 320
N H V+ LL G+D N +TN++ L L A +G +V +LL + R ++
Sbjct: 1199 MNGHVPAVKLLLDMGSDINAQIETNRNTALTL--ACFQGRAEVVSLLLDRKANVEHRAKT 1256
Query: 321 GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATE 380
G++PL AA + EV LL DVN P P R +AL A + E
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP-------SSRDTALTIAADKGHYKFCE 1309
Query: 381 LLLQHGAD---PNRDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421
LL+ GA N+ +PL +A G +QLL+ GA++DA
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Score = 100 bits (250), Expect = 3e-21
Identities = 76/255 (29%), Positives = 119/255 (46%), Gaps = 6/255 (2%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A G +E + ++ G N N + PL AA G V +K+L A I+
Sbjct: 1125 PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA-GAEINS 1183
Query: 120 RTLQEE--TAVYLATCRGHLDCLLSLLQAGAEPDIS-NKSRETPLYKACERKNAEAVKIL 176
RT + + + LA GH+ + LL G++ + +R T L AC + AE V +L
Sbjct: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243
Query: 177 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGI--TPLFVAAQSG 234
+ A+ HR G T L E+ S EV ++L+ GA V + T L +AA G
Sbjct: 1244 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1303
Query: 235 QLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLH 294
+ L GA I+ + + L+ A H +VV+ L+ GAD + + + PL
Sbjct: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLM 1363
Query: 295 IASKKGNYRIVQMLL 309
A +KG+ ++VQ L+
Sbjct: 1364 SAFRKGHVKVVQYLV 1378
Score = 66.6 bits (161), Expect = 6e-11
Identities = 57/186 (30%), Positives = 94/186 (50%), Gaps = 17/186 (9%)
Query: 248 DINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQM 307
D +T+ S++ +AL AC HEE+V L+++ A +K G PL +A+ G+ +V++
Sbjct: 1048 DAHTE-SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 308 LLPVTS--RTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSS 365
LL + R+ +PL LA EV++ LL+ A + R D +
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARG-------ANKEHRNVSDY--T 1157
Query: 366 ALYFAVVNNNVYATELLLQHGADPNRDV-----ISPLLVAIRHGCLRTMQLLLDHGANID 420
L A V ++LL GA+ N ISPL++A +G + ++LLLD G++I+
Sbjct: 1158 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
Query: 421 AYIATH 426
A I T+
Sbjct: 1218 AQIETN 1223
Score = 53.9 bits (128), Expect = 4e-07
Identities = 48/208 (23%), Positives = 85/208 (40%), Gaps = 35/208 (16%)
Query: 54 QLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAY 113
+L + PL++A ++G E +K ++ G N
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGAN------------------------------- 560
Query: 114 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV 173
+ T +TA+ A GH D LLQAGA+ + ++ TPL KA + V
Sbjct: 561 ---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617
Query: 174 KILVQHNADTNH-RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232
+ L+ A+ N N T + + + L V+++L++ GA + G T L AA+
Sbjct: 618 QFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 677
Query: 233 SGQLEALRFLAKYGADINTQASDNASAL 260
G + +L Y ++ + + + S L
Sbjct: 678 GGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 140 bits (353), Expect = 3e-33
Identities = 105/371 (28%), Positives = 174/371 (46%), Gaps = 10/371 (2%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L +A DGD A++ ++ EG+++ E +EG L A G +VL + D+
Sbjct: 209 LAEACSDGDVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 268
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
+ T + A+ G+LD + LL A+ + + + T L AC + VK+L+
Sbjct: 269 NKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEG 328
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVES-KNAYGITPLFVAAQSGQLEAL 239
A+ G T L E+ S +EV ++L+ GA + + N + + L +A G L+ +
Sbjct: 329 ANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMV 388
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
RFL + GAD + + +AL EAC + H EV LL GA N PL +A+
Sbjct: 389 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 448
Query: 300 GNYRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ + +L+ + + G +PL AA H+E++ LL+ ++N
Sbjct: 449 GHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQT------- 501
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN 418
E+ + +AL A + L++ GAD +PL+ A + G L ++ LL GAN
Sbjct: 502 -EETQETALTLACCGGFSEVADFLIKAGADIELGCSTPLMEASQEGHLELVKYLLASGAN 560
Query: 419 IDAYIATHPTA 429
+ A AT TA
Sbjct: 561 VHATTATGDTA 571
Score = 136 bits (342), Expect = 6e-32
Identities = 116/401 (28%), Positives = 176/401 (43%), Gaps = 33/401 (8%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L A G + +K ++ EG N+ + N+ G PL EAA G V +VL G
Sbjct: 309 LTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHS 368
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
+E+A+ LA +GHLD + LL+AGA+ + T L +AC + E ++L+
Sbjct: 369 NEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 428
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
A N + + L + +E+ +L+ GA +E N G TPL AA+ G E +
Sbjct: 429 AQVNMPADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVA 488
Query: 241 FLAKYGADINTQASDNA-SALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
L GA+IN Q + +AL AC EV +FL+ GAD PL AS++
Sbjct: 489 LLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCST---PLMEASQE 545
Query: 300 GNYRIVQMLLPVTSRTRIRRS-GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ +V+ LL + + G + L A E H +V + LL A D+ R L
Sbjct: 546 GHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 605
Query: 359 YEDRRSSALYF-------------AVVNNN------------VYATELLLQHGADPN--- 390
+ R+ L A NN+ + ELLL HGADP
Sbjct: 606 MKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRL 665
Query: 391 RDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFP 431
+D + L+ A + G + LLD+ N+ + T + P
Sbjct: 666 KDGSTMLIEAAKGGHTNVVSYLLDYPNNVLSVPTTDVSQLP 706
Score = 119 bits (299), Expect = 6e-27
Identities = 88/258 (34%), Positives = 127/258 (49%), Gaps = 8/258 (3%)
Query: 57 PAD----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA 112
PAD PL A G E +I+ G NL E N EG+ PL EAA G + +L
Sbjct: 434 PADSFESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQ 493
Query: 113 YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172
Q +ETA+ LA C G + L++AGA+ ++ TPL +A + + E
Sbjct: 494 GANINAQTEETQETALTLACCGGFSEVADFLIKAGADIELGCS---TPLMEASQEGHLEL 550
Query: 173 VKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232
VK L+ A+ + G TAL + +V +L+ GA +E ++ G TPL AA+
Sbjct: 551 VKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 610
Query: 233 SGQLEALRFLAKYGADINTQASDNASALYE-ACKNEHEEVVEFLLSQGADANKTNKDGLL 291
+G L ++FL GA++N ++N + AC H VVE LL+ GAD KDG
Sbjct: 611 AGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGST 670
Query: 292 PLHIASKKGNYRIVQMLL 309
L A+K G+ +V LL
Sbjct: 671 MLIEAAKGGHTNVVSYLL 688
Score = 118 bits (295), Expect = 2e-26
Identities = 108/399 (27%), Positives = 188/399 (47%), Gaps = 18/399 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL+ A G + +K ++ ++ + G L A G V +KVL I+
Sbjct: 275 PLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNE-GANIED 333
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI-SNKSRETPLYKACERKNAEAVKILVQ 178
T + A GH++ LL GA + SN+ +E+ L AC + + + V+ L++
Sbjct: 334 HNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLE 393
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
AD H+ + TAL E+ +EV ++L+ GA+V +PL +AA G +E
Sbjct: 394 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 453
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDGLLPLHIAS 297
L + GA++ + + L EA + HEE+V LL+QGA+ N +T + L +A
Sbjct: 454 AALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLAC 513
Query: 298 KKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
G + L+ + + S +PL A++ H E+++ LL++ +V+ A
Sbjct: 514 CGGFSEVADFLIKAGADIELGCS--TPLMEASQEGHLELVKYLLASGANVHATTA----- 566
Query: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDV---ISPLLVAIRHGCLRTMQLLLD 414
+AL +A N + ++LLQ GAD + +PL+ A R G L T+Q L+
Sbjct: 567 ----TGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLIS 622
Query: 415 HGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCD 453
GAN++ A + ++ A L++++ L+ G D
Sbjct: 623 KGANVNRATANNDHTV-VSLACAGGHLAVVELLLAHGAD 660
Score = 112 bits (279), Expect = 1e-24
Identities = 90/309 (29%), Positives = 152/309 (49%), Gaps = 23/309 (7%)
Query: 117 IDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI-SNKSRETPLYKACERKNAEAVKI 175
I+ R + T + LA GH+ + LL G + + S ++++TPL AC E V +
Sbjct: 1081 IEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDL 1140
Query: 176 LVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESK--NAYGITPLFVAAQS 233
L+ A+ HR +T L + S + +++IL++ GA++ S+ + GI+PL +AA +
Sbjct: 1141 LLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMN 1200
Query: 234 GQLEALRFLAKYGADINTQASDNA-SALYEACKNEHEEVVEFLLSQGADANKTNKDGLLP 292
G + A++ L G+DIN Q N +AL AC EVV LL + A+ K GL P
Sbjct: 1201 GHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTP 1260
Query: 293 LHIASKKGNYRIVQMLLPV---TSRTRIRRSGVSPLHLAAERNHDEVLEALL--SARFDV 347
L A+ G + ++LL + + S + L +AA++ H + E L+ A DV
Sbjct: 1261 LMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDV 1320
Query: 348 NTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHG 404
+ ++ L+ A + +LL+Q GAD + I+PL+ A R G
Sbjct: 1321 R-----------NKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKG 1369
Query: 405 CLRTMQLLL 413
++ +Q L+
Sbjct: 1370 HVKVVQYLV 1378
Score = 111 bits (277), Expect = 2e-24
Identities = 117/404 (28%), Positives = 177/404 (43%), Gaps = 26/404 (6%)
Query: 30 PARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKE 89
P A G QG++ + L + PA L + D A+ T + G N + E
Sbjct: 964 PQIAITGHDQGLLVQEPDGLMVAT---PAQTLTDTLDDLIA-AVSTRVPTGSNSSSQTTE 1019
Query: 90 GWLPLHEAAYYGQVGCLKVLQRAYPGT-IDQRT-LQEETAVYLATCRGHLDCLLSLLQAG 147
P + V + + YP ID T +TA+ LA GH + + L+
Sbjct: 1020 CLTPESCSQTTSNVAS-QSMPPVYPSVDIDAHTESNHDTALTLACAGGHEELVSVLIARD 1078
Query: 148 AEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGW-TALHESVSRNDLEVM 206
A+ + +K TPL A + V+IL+ D + R T L + S EV+
Sbjct: 1079 AKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVV 1138
Query: 207 QILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASD--NASALYEAC 264
+L++ GA E +N TPL +AA G + ++ L GA+IN++ S L A
Sbjct: 1139 DLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAA 1198
Query: 265 KNEHEEVVEFLLSQGADAN---KTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RS 320
N H V+ LL G+D N +TN++ L L A +G +V +LL + R ++
Sbjct: 1199 MNGHVPAVKLLLDMGSDINAQIETNRNTALTL--ACFQGRAEVVSLLLDRKANVEHRAKT 1256
Query: 321 GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATE 380
G++PL AA + EV LL DVN P P R +AL A + E
Sbjct: 1257 GLTPLMEAASGGYAEVGRVLLDKGADVNAPPVP-------SSRDTALTIAADKGHYKFCE 1309
Query: 381 LLLQHGAD---PNRDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421
LL+ GA N+ +PL +A G +QLL+ GA++DA
Sbjct: 1310 LLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDA 1353
Score = 100 bits (250), Expect = 3e-21
Identities = 76/255 (29%), Positives = 119/255 (46%), Gaps = 6/255 (2%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A G +E + ++ G N N + PL AA G V +K+L A I+
Sbjct: 1125 PLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA-GAEINS 1183
Query: 120 RTLQEE--TAVYLATCRGHLDCLLSLLQAGAEPDIS-NKSRETPLYKACERKNAEAVKIL 176
RT + + + LA GH+ + LL G++ + +R T L AC + AE V +L
Sbjct: 1184 RTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRAEVVSLL 1243
Query: 177 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGI--TPLFVAAQSG 234
+ A+ HR G T L E+ S EV ++L+ GA V + T L +AA G
Sbjct: 1244 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1303
Query: 235 QLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLH 294
+ L GA I+ + + L+ A H +VV+ L+ GAD + + + PL
Sbjct: 1304 HYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLLVQAGADVDAADNRKITPLM 1363
Query: 295 IASKKGNYRIVQMLL 309
A +KG+ ++VQ L+
Sbjct: 1364 SAFRKGHVKVVQYLV 1378
Score = 66.6 bits (161), Expect = 6e-11
Identities = 57/186 (30%), Positives = 94/186 (50%), Gaps = 17/186 (9%)
Query: 248 DINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQM 307
D +T+ S++ +AL AC HEE+V L+++ A +K G PL +A+ G+ +V++
Sbjct: 1048 DAHTE-SNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEI 1106
Query: 308 LLPVTS--RTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSS 365
LL + R+ +PL LA EV++ LL+ A + R D +
Sbjct: 1107 LLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARG-------ANKEHRNVSDY--T 1157
Query: 366 ALYFAVVNNNVYATELLLQHGADPNRDV-----ISPLLVAIRHGCLRTMQLLLDHGANID 420
L A V ++LL GA+ N ISPL++A +G + ++LLLD G++I+
Sbjct: 1158 PLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDIN 1217
Query: 421 AYIATH 426
A I T+
Sbjct: 1218 AQIETN 1223
Score = 53.9 bits (128), Expect = 4e-07
Identities = 48/208 (23%), Positives = 85/208 (40%), Gaps = 35/208 (16%)
Query: 54 QLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAY 113
+L + PL++A ++G E +K ++ G N
Sbjct: 532 ELGCSTPLMEASQEGHLELVKYLLASGAN------------------------------- 560
Query: 114 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV 173
+ T +TA+ A GH D LLQAGA+ + ++ TPL KA + V
Sbjct: 561 ---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLCTV 617
Query: 174 KILVQHNADTNH-RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232
+ L+ A+ N N T + + + L V+++L++ GA + G T L AA+
Sbjct: 618 QFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 677
Query: 233 SGQLEALRFLAKYGADINTQASDNASAL 260
G + +L Y ++ + + + S L
Sbjct: 678 GGHTNVVSYLLDYPNNVLSVPTTDVSQL 705
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 139 bits (351), Expect = 6e-33
Identities = 113/385 (29%), Positives = 179/385 (46%), Gaps = 32/385 (8%)
Query: 68 GDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL----QRAYPGTIDQRTLQ 123
G E+ + +++ G + + + EG L AAY G ++ L +D RT
Sbjct: 655 GHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTAL 714
Query: 124 EETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT 183
A+ + +GH + L+ GAE D +K TPL A + + V +L++ AD
Sbjct: 715 SVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADV 774
Query: 184 NHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLA 243
+H N G T L + S V+ L+ GA V+S ++ G T L +A+ G +E +R L
Sbjct: 775 DHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLL 834
Query: 244 KYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYR 303
G D N + + L+ A H + E L+ QGA N+ + DG +P +AS++G+Y
Sbjct: 835 DRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYD 894
Query: 304 IVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY--- 359
VQ+LL S R G + L +AA H +++E L S DVN A R LY
Sbjct: 895 CVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILA 954
Query: 360 -EDRRSSALYFAVVNNNVYAT--------------------ELLLQHGADPN---RDVIS 395
E++ + A YF NV A+ ++L+ + AD N + S
Sbjct: 955 LENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRS 1014
Query: 396 PLLVAIRHGCLRTMQLLLDHGANID 420
L A G ++ +QLL++HGA +D
Sbjct: 1015 ALQSAAWQGHVKVVQLLIEHGAVVD 1039
Score = 139 bits (350), Expect = 7e-33
Identities = 118/406 (29%), Positives = 182/406 (44%), Gaps = 40/406 (9%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGT-ID 118
PL A + G + + +I G N+ +++GW L AA+ G + L Y G +D
Sbjct: 581 PLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSAL--LYAGVKVD 638
Query: 119 QRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQ 178
TA+ A GH D +L+LLQ GAE + ++ T L A + E V+ L+
Sbjct: 639 CADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLD 698
Query: 179 HNADTNHRCNRGWTALHES-----VSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQS 233
H A+ NH G TAL + S+ V+ +L+ GA+V+ + G+TPL VAA
Sbjct: 699 HGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYE 758
Query: 234 GQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPL 293
G ++ + L + GAD++ ++ + L A H VV LL GA + + +G L
Sbjct: 759 GHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL 818
Query: 294 HIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEALL----------- 341
IAS +GN +V+ LL R +G +PLH+AA H + EAL+
Sbjct: 819 SIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDN 878
Query: 342 -----------SARFDVNTPLAPERARL----YEDRRSSALYFAVVNNNVYATELLLQHG 386
+D L ++ + Y+ R +AL A + + ELL HG
Sbjct: 879 DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGR--NALRVAALEGHRDIVELLFSHG 936
Query: 387 ADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTA 429
AD N D L + L + L++GAN++A A TA
Sbjct: 937 ADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTA 982
Score = 128 bits (321), Expect = 2e-29
Identities = 97/379 (25%), Positives = 169/379 (44%), Gaps = 29/379 (7%)
Query: 68 GDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETA 127
G + +I G + +K+G PL AAY G V + +L +D T
Sbjct: 726 GHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEG-GADVDHTDNNGRTP 784
Query: 128 VYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRC 187
+ A GH + +LL GA D + T L A + N E V+ L+ D NHR
Sbjct: 785 LLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRD 844
Query: 188 NRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGA 247
+ GWT LH + + + L+ GA+ + G P +A+Q G + ++ L + +
Sbjct: 845 DAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKS 904
Query: 248 DINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQM 307
+I+ + D +AL A H ++VE L S GAD N + DG L+I + + + +
Sbjct: 905 NIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEY 964
Query: 308 LLPVTSRTRIRRS-GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYE------ 360
L + + G + LH++ + H E+++ L++ DVN +R+ L
Sbjct: 965 FLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGH 1024
Query: 361 ------------------DRRSSALYFAVVNNNVYATELLLQHGADPNR-DVI--SPLLV 399
++ ++AL A ++ ++LL+HGADPN D + + V
Sbjct: 1025 VKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRV 1084
Query: 400 AIRHGCLRTMQLLLDHGAN 418
A ++G + ++LL +GA+
Sbjct: 1085 AAKNGHSQIIKLLEKYGAS 1103
Score = 112 bits (281), Expect = 7e-25
Identities = 80/280 (28%), Positives = 130/280 (46%), Gaps = 6/280 (2%)
Query: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL--QRAYPGTIDQRT 121
A G+ E ++T++ G + + GW PLH AA+ G + L Q A ID
Sbjct: 821 ASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDN-- 878
Query: 122 LQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNA 181
LA+ GH DC+ LL+ + D L A + + V++L H A
Sbjct: 879 -DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGA 937
Query: 182 DTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRF 241
D N + G L+ N L + + + GA VE+ +A G T L V+ G +E ++
Sbjct: 938 DVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQV 997
Query: 242 LAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGN 301
L Y AD+N ++ SAL A H +VV+ L+ GA + T G L IA+++G+
Sbjct: 998 LIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGH 1057
Query: 302 YRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEAL 340
+VQ+LL + G + + +AA+ H ++++ L
Sbjct: 1058 IDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 107 bits (268), Expect = 2e-23
Identities = 92/335 (27%), Positives = 147/335 (43%), Gaps = 33/335 (9%)
Query: 116 TIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKI 175
+++Q T + A G LD + L+ GA+ +I + TPL A + + + V
Sbjct: 537 SVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNC 596
Query: 176 LVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQ 235
L+ A+ NH GWTAL + EV+ L+ G KV+ +A T L AA G
Sbjct: 597 LIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGH 656
Query: 236 LEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHI 295
+ + L ++GA++N ++ +AL A H E+VE LL GA+ N + DG L +
Sbjct: 657 EDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSV 716
Query: 296 A-----SKKGNYRIVQMLLPVTSRT-RIRRSGVSPLHLAAERNHDEVLEALLSARFDVN- 348
A + KG+ +V +L+ + + G++PL +AA H +V++ LL DV+
Sbjct: 717 AALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDH 776
Query: 349 ------TPLAPERARLY-----------------EDRRSSALYFAVVNNNVYATELLLQH 385
TPL + + + + L A NV LL
Sbjct: 777 TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Query: 386 GADPN-RDVI--SPLLVAIRHGCLRTMQLLLDHGA 417
G D N RD +PL +A G + L++ GA
Sbjct: 837 GLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGA 871
Score = 92.0 bits (227), Expect = 1e-18
Identities = 69/273 (25%), Positives = 121/273 (44%), Gaps = 36/273 (13%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A +G + +I++G E + +G +P A+ G C+++L IDQ
Sbjct: 850 PLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLEN-KSNIDQ 908
Query: 120 RTLQEETAVYLATCRGHLDCLLSL---------------------------------LQA 146
R A+ +A GH D + L L+
Sbjct: 909 RGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLEN 968
Query: 147 GAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVM 206
GA + S+ T L+ +C + + E V++L+ ++AD N N +AL + + ++V+
Sbjct: 969 GANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVV 1028
Query: 207 QILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKN 266
Q+L+ GA V+ G T L +AAQ G ++ ++ L ++GAD N +A+ A KN
Sbjct: 1029 QLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKN 1088
Query: 267 EHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
H ++++ L G A+ N P+H +K
Sbjct: 1089 GHSQIIKLLEKYG--ASSLNGCSPSPVHTMEQK 1119
Score = 88.6 bits (218), Expect = 1e-17
Identities = 92/361 (25%), Positives = 157/361 (43%), Gaps = 61/361 (16%)
Query: 138 DCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHES 197
+ L L++AGA + + + +A ER+ ++++ L+ + A N + G T L +
Sbjct: 495 EVLQLLVKAGAHVNSEDDRTSCIVRQALERE--DSIRTLLDNGASVNQCDSNGRTLLANA 552
Query: 198 VSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADIN------- 250
L+V+ +LVS GA +E ++A+G TPL +AA+ G + + L GA+IN
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612
Query: 251 --------------------------TQASDNASALYEACKNEHEEVVEFLLSQGADANK 284
+D+ +AL A HE++V LL GA+ NK
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNK 672
Query: 285 TNKDGLLPLHIASKKGNYRIVQMLL---------PVTSRTRIRRSGVSPLHLAAERNHDE 335
+ +G L A+ G+ IV+ LL V RT + V+ L + A + H
Sbjct: 673 ADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTAL---SVAALCVPASKGHAS 729
Query: 336 VLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRD 392
V+ L+ +V+ + + L A +V +LLL+ GAD + +
Sbjct: 730 VVSLLIDRGAEVDH---------CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNN 780
Query: 393 VISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGC 452
+PLL A G + LL GA +D+ + T +I A + +++ L+D G
Sbjct: 781 GRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVL--SIASAQGNVEVVRTLLDRGL 838
Query: 453 D 453
D
Sbjct: 839 D 839
Score = 76.6 bits (187), Expect = 6e-14
Identities = 76/276 (27%), Positives = 126/276 (45%), Gaps = 21/276 (7%)
Query: 192 TALHESVSR---NDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGAD 248
T + +S+S + EV+Q+LV GA V S++ T V + +++R L GA
Sbjct: 480 TPVRDSLSTLIPKEQEVLQLLVKAGAHVNSED--DRTSCIVRQALEREDSIRTLLDNGAS 537
Query: 249 INTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQML 308
+N S+ + L A + +VV L+S+GAD + G PL +A+++G+ ++V L
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCL 597
Query: 309 LPVTSR-TRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSAL 367
+ + + G + L AA H EV+ ALL A V+ A R +AL
Sbjct: 598 IGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSR---------TAL 648
Query: 368 YFAVVNNNVYATELLLQHGADPNR---DVISPLLVAIRHGCLRTMQLLLDHGANIDAYIA 424
A + LLQHGA+ N+ + + L+ A G ++ LLDHGA ++
Sbjct: 649 RAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDV 708
Query: 425 THPTAFPATIMFAMKC---LSLLKFLMDLGCDGEPC 457
TA + S++ L+D G + + C
Sbjct: 709 DGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHC 744
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 139 bits (349), Expect = 9e-33
Identities = 105/371 (28%), Positives = 172/371 (46%), Gaps = 10/371 (2%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L +A +GD A++ ++ EG+++ E +EG L A G +VL + D+
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
+ T + A GH+ + LL A+ + + + T L AC + VK+L++
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVES-KNAYGITPLFVAAQSGQLEAL 239
A G T L E+ S +EV ++L+ GA + + N + + L +A G LE +
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
RFL + GAD + + +AL EAC + H EV LL GA N PL +A+
Sbjct: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477
Query: 300 GNYRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ + +L+ S + G +PL AA H+E++ LL ++N
Sbjct: 478 GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT------- 530
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN 418
E+ + +AL A + + L++ GAD +PL+ A + G L ++ LL GAN
Sbjct: 531 -EETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGAN 589
Query: 419 IDAYIATHPTA 429
+ A AT TA
Sbjct: 590 VHATTATGDTA 600
Score = 127 bits (319), Expect = 3e-29
Identities = 103/364 (28%), Positives = 166/364 (45%), Gaps = 18/364 (4%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L A G + +K +++ G ++ + N+ G PL EA G V ++L G
Sbjct: 338 LTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
+E+A+ LA +GHL+ + LL+AGA+ + T L +AC + E ++L+
Sbjct: 398 NEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
A N + + L + +E+ +L+ GA +E N G TPL AA+ G E +
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
Query: 241 FLAKYGADINTQASD-NASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
L GA+IN Q + +AL AC EV +FL+ GAD PL A+++
Sbjct: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQE 574
Query: 300 GNYRIVQMLLPVTSRTR-IRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ +V+ LL + +G + L A E H +V + LL A D+ R L
Sbjct: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 634
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVI----SPLLVAIRHGCLRTMQLLLD 414
+ R+ +V + L+ GA+ NR + L +A G L ++LLL
Sbjct: 635 MKAARA---------GHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 415 HGAN 418
HGA+
Sbjct: 686 HGAD 689
Score = 122 bits (307), Expect = 7e-28
Identities = 105/372 (28%), Positives = 177/372 (47%), Gaps = 17/372 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL+ A G + +K ++ ++ + G L A G V +KVL + +I+
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES-GASIED 362
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI-SNKSRETPLYKACERKNAEAVKILVQ 178
T + A GH++ LL+ GA + SN+ +E+ L AC + + E V+ L++
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
AD H+ + TAL E+ +EV ++L+ GA+V +PL +AA G +E
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDGLLPLHIAS 297
L + GA + + + L EA + HEE+V LL QGA+ N +T + L +A
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
Query: 298 KKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
G + L+ + + S +PL AA+ H E+++ LL+A +V+ A
Sbjct: 543 CGGFLEVADFLIKAGADIELGCS--TPLMEAAQEGHLELVKYLLAAGANVHATTATG--- 597
Query: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVI---SPLLVAIRHGCLRTMQLLLD 414
+AL +A N + ++LLQ GAD + +PL+ A R G + T+Q L+
Sbjct: 598 ------DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
Query: 415 HGANIDAYIATH 426
GAN++ A +
Sbjct: 652 KGANVNRTTANN 663
Score = 120 bits (300), Expect = 5e-27
Identities = 104/321 (32%), Positives = 156/321 (48%), Gaps = 21/321 (6%)
Query: 113 YPGT-IDQRT-LQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNA 170
YP ID +T +TA+ LA GH + + +LL+ GA + +K TPL A +
Sbjct: 1070 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHV 1129
Query: 171 EAVKILVQHNADTNHRCNRGW-TALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFV 229
V+IL+ + AD + R T L + S EV+++L++ GA E +N TPL +
Sbjct: 1130 GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 1189
Query: 230 AAQSGQLEALRFLAKYGADINTQASD--NASALYEACKNEHEEVVEFLLSQGADAN---K 284
AA G + ++ L GA+IN++ S L A N H V+ LL G+D N +
Sbjct: 1190 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE 1249
Query: 285 TNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEALLSA 343
TN++ L L A +G +V +LL + R ++G++PL AA + EV LL
Sbjct: 1250 TNRNTALTL--ACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1307
Query: 344 RFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVA 400
DVN P P R +AL A + ELL+ GA N+ +PL +A
Sbjct: 1308 GADVNAPPVP-------SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLA 1360
Query: 401 IRHGCLRTMQLLLDHGANIDA 421
G L +QLL+ GA++DA
Sbjct: 1361 ANGGHLDVVQLLVQAGADVDA 1381
Score = 119 bits (298), Expect = 8e-27
Identities = 89/258 (34%), Positives = 131/258 (50%), Gaps = 8/258 (3%)
Query: 57 PAD----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA 112
PAD PL A G E +I+ G +L E N EG+ PL EAA G + +L
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 113 YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172
Q +ETA+ LA C G L+ L++AGA+ ++ TPL +A + + E
Sbjct: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQEGHLEL 579
Query: 173 VKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232
VK L+ A+ + G TAL + +V +L+ GA +E ++ G TPL AA+
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
Query: 233 SGQLEALRFLAKYGADIN-TQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLL 291
+G + ++FL GA++N T A+++ + L AC H VVE LL+ GAD KDG
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
Query: 292 PLHIASKKGNYRIVQMLL 309
L A+K G+ +V LL
Sbjct: 700 MLIEAAKGGHTSVVCYLL 717
Score = 115 bits (289), Expect = 9e-26
Identities = 109/416 (26%), Positives = 189/416 (45%), Gaps = 66/416 (15%)
Query: 11 SLFHSCSAPSRSTAPPESSPARAPMGLFQGV-MQKYSSSLFKTSQLAPADPLIKAIKDGD 69
S+ S S P T P SP+ A + ++ + + + S T+ L A G
Sbjct: 1044 SIAASISQPQTPTPSPIISPS-AMLPIYPAIDIDAQTESNHDTA-------LTLACAGGH 1095
Query: 70 EEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVY 129
EE ++T+++ G ++ +K+G+ PL
Sbjct: 1096 EELVQTLLERGASIEHRDKKGFTPL----------------------------------I 1121
Query: 130 LATCRGHLDCLLSLLQAGAEPDI-SNKSRETPLYKACERKNAEAVKILVQHNADTNHRCN 188
LA GH+ + LL GA+ + S ++++TPL AC E V++L+ A+ HR
Sbjct: 1122 LAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNV 1181
Query: 189 RGWTALHESVSRNDLEVMQILVSGGAKVESK--NAYGITPLFVAAQSGQLEALRFLAKYG 246
+T L + S + +++IL++ GA++ S+ + GI+PL +AA +G A++ L G
Sbjct: 1182 SDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMG 1241
Query: 247 ADINTQASDNA-SALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIV 305
+DIN Q N +AL AC EVV LL + A+ K GL PL A+ G +
Sbjct: 1242 SDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVG 1301
Query: 306 QMLLPV---TSRTRIRRSGVSPLHLAAERNHDEVLEALL--SARFDVNTPLAPERARLYE 360
++LL + + S + L +AA++ H + E L+ A DV
Sbjct: 1302 RVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVR-----------N 1350
Query: 361 DRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTMQLLL 413
+ ++ L+ A ++ +LL+Q GAD + I+PL+ A R G ++ ++ L+
Sbjct: 1351 KKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Score = 102 bits (255), Expect = 8e-22
Identities = 84/289 (29%), Positives = 133/289 (46%), Gaps = 32/289 (11%)
Query: 141 LSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSR 200
+S Q I + S P+Y A + + ++NH TAL + +
Sbjct: 1049 ISQPQTPTPSPIISPSAMLPIYPAID----------IDAQTESNHD-----TALTLACAG 1093
Query: 201 NDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQAS-DNASA 259
E++Q L+ GA +E ++ G TPL +AA +G + + L GADI Q+ +
Sbjct: 1094 GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 1153
Query: 260 LYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL----PVTSRT 315
L AC +EVVE LL++GA+ N PL +A+ G I+++LL + SRT
Sbjct: 1154 LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 1213
Query: 316 RIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNN 375
+ G+SPL LAA H ++ LL D+N + E R++AL A
Sbjct: 1214 G-SKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI--------ETNRNTALTLACFQGR 1264
Query: 376 VYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421
LLL A+ + ++PL+ A G ++LLD GA+++A
Sbjct: 1265 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1313
Score = 84.7 bits (208), Expect = 2e-16
Identities = 67/257 (26%), Positives = 110/257 (42%), Gaps = 39/257 (15%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A G +E ++ ++ G N N + PL AA G V +K+L A I+
Sbjct: 1153 PLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA-GAEINS 1211
Query: 120 RTLQEE--TAVYLATCRGHLDCLLSLLQAGAEPDIS-NKSRETPLYKACERKNAEAVKIL 176
RT + + + LA GH + LL G++ + +R T L AC + E V +L
Sbjct: 1212 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1271
Query: 177 VQHNADTNHRCNRGWTALHESVSRNDLEV------------------------------- 205
+ A+ HR G T L E+ S EV
Sbjct: 1272 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1331
Query: 206 ----MQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALY 261
++L+ GA ++ +N G TPL++AA G L+ ++ L + GAD++ + + L
Sbjct: 1332 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM 1391
Query: 262 EACKNEHEEVVEFLLSQ 278
A + H +VV +L+ +
Sbjct: 1392 AAFRKGHVKVVRYLVKE 1408
Score = 72.8 bits (177), Expect = 8e-13
Identities = 61/187 (32%), Positives = 92/187 (49%), Gaps = 17/187 (9%)
Query: 248 DINTQASDNA-SALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQ 306
DI+ Q N +AL AC HEE+V+ LL +GA +K G PL +A+ G+ +V+
Sbjct: 1074 DIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVE 1133
Query: 307 MLLP--VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRS 364
+LL + R+ +PL LA EV+E LL+ A + R D
Sbjct: 1134 ILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARG-------ANKEHRNVSD--Y 1184
Query: 365 SALYFAVVNNNVYATELLLQHGADPNRDV-----ISPLLVAIRHGCLRTMQLLLDHGANI 419
+ L A V ++LL GA+ N ISPL++A +G ++LLLD G++I
Sbjct: 1185 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 1244
Query: 420 DAYIATH 426
+A I T+
Sbjct: 1245 NAQIETN 1251
Score = 53.5 bits (127), Expect = 5e-07
Identities = 47/193 (24%), Positives = 78/193 (40%), Gaps = 35/193 (18%)
Query: 54 QLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAY 113
+L + PL++A ++G E +K ++ G N
Sbjct: 561 ELGCSTPLMEAAQEGHLELVKYLLAAGAN------------------------------- 589
Query: 114 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV 173
+ T +TA+ A GH D LLQAGA+ + ++ TPL KA + V
Sbjct: 590 ---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646
Query: 174 KILVQHNADTNH-RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232
+ L+ A+ N N T L + + L V+++L++ GA + G T L AA+
Sbjct: 647 QFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 706
Query: 233 SGQLEALRFLAKY 245
G + +L Y
Sbjct: 707 GGHTSVVCYLLDY 719
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 139 bits (349), Expect = 9e-33
Identities = 105/371 (28%), Positives = 172/371 (46%), Gaps = 10/371 (2%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L +A +GD A++ ++ EG+++ E +EG L A G +VL + D+
Sbjct: 238 LAEACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRG 297
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
+ T + A GH+ + LL A+ + + + T L AC + VK+L++
Sbjct: 298 IKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESG 357
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVES-KNAYGITPLFVAAQSGQLEAL 239
A G T L E+ S +EV ++L+ GA + + N + + L +A G LE +
Sbjct: 358 ASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMV 417
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
RFL + GAD + + +AL EAC + H EV LL GA N PL +A+
Sbjct: 418 RFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACG 477
Query: 300 GNYRIVQMLLP-VTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ + +L+ S + G +PL AA H+E++ LL ++N
Sbjct: 478 GHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQT------- 530
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGAN 418
E+ + +AL A + + L++ GAD +PL+ A + G L ++ LL GAN
Sbjct: 531 -EETQETALTLACCGGFLEVADFLIKAGADIELGCSTPLMEAAQEGHLELVKYLLAAGAN 589
Query: 419 IDAYIATHPTA 429
+ A AT TA
Sbjct: 590 VHATTATGDTA 600
Score = 127 bits (319), Expect = 3e-29
Identities = 103/364 (28%), Positives = 166/364 (45%), Gaps = 18/364 (4%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L A G + +K +++ G ++ + N+ G PL EA G V ++L G
Sbjct: 338 LTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHS 397
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
+E+A+ LA +GHL+ + LL+AGA+ + T L +AC + E ++L+
Sbjct: 398 NEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSG 457
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
A N + + L + +E+ +L+ GA +E N G TPL AA+ G E +
Sbjct: 458 AQVNMPADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVA 517
Query: 241 FLAKYGADINTQASD-NASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKK 299
L GA+IN Q + +AL AC EV +FL+ GAD PL A+++
Sbjct: 518 LLLGQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIELGCS---TPLMEAAQE 574
Query: 300 GNYRIVQMLLPVTSRTR-IRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARL 358
G+ +V+ LL + +G + L A E H +V + LL A D+ R L
Sbjct: 575 GHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPL 634
Query: 359 YEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVI----SPLLVAIRHGCLRTMQLLLD 414
+ R+ +V + L+ GA+ NR + L +A G L ++LLL
Sbjct: 635 MKAARA---------GHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 415 HGAN 418
HGA+
Sbjct: 686 HGAD 689
Score = 122 bits (307), Expect = 7e-28
Identities = 105/372 (28%), Positives = 177/372 (47%), Gaps = 17/372 (4%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL+ A G + +K ++ ++ + G L A G V +KVL + +I+
Sbjct: 304 PLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLES-GASIED 362
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI-SNKSRETPLYKACERKNAEAVKILVQ 178
T + A GH++ LL+ GA + SN+ +E+ L AC + + E V+ L++
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
AD H+ + TAL E+ +EV ++L+ GA+V +PL +AA G +E
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVEL 482
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN-KTNKDGLLPLHIAS 297
L + GA + + + L EA + HEE+V LL QGA+ N +T + L +A
Sbjct: 483 AALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLAC 542
Query: 298 KKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERAR 357
G + L+ + + S +PL AA+ H E+++ LL+A +V+ A
Sbjct: 543 CGGFLEVADFLIKAGADIELGCS--TPLMEAAQEGHLELVKYLLAAGANVHATTATG--- 597
Query: 358 LYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVI---SPLLVAIRHGCLRTMQLLLD 414
+AL +A N + ++LLQ GAD + +PL+ A R G + T+Q L+
Sbjct: 598 ------DTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLIS 651
Query: 415 HGANIDAYIATH 426
GAN++ A +
Sbjct: 652 KGANVNRTTANN 663
Score = 120 bits (300), Expect = 5e-27
Identities = 104/321 (32%), Positives = 156/321 (48%), Gaps = 21/321 (6%)
Query: 113 YPGT-IDQRT-LQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNA 170
YP ID +T +TA+ LA GH + + +LL+ GA + +K TPL A +
Sbjct: 819 YPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHV 878
Query: 171 EAVKILVQHNADTNHRCNRGW-TALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFV 229
V+IL+ + AD + R T L + S EV+++L++ GA E +N TPL +
Sbjct: 879 GVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 938
Query: 230 AAQSGQLEALRFLAKYGADINTQASDNA--SALYEACKNEHEEVVEFLLSQGADAN---K 284
AA G + ++ L GA+IN++ S L A N H V+ LL G+D N +
Sbjct: 939 AASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIE 998
Query: 285 TNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEALLSA 343
TN++ L L A +G +V +LL + R ++G++PL AA + EV LL
Sbjct: 999 TNRNTALTL--ACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDK 1056
Query: 344 RFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVA 400
DVN P P R +AL A + ELL+ GA N+ +PL +A
Sbjct: 1057 GADVNAPPVP-------SSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLA 1109
Query: 401 IRHGCLRTMQLLLDHGANIDA 421
G L +QLL+ GA++DA
Sbjct: 1110 ANGGHLDVVQLLVQAGADVDA 1130
Score = 119 bits (298), Expect = 8e-27
Identities = 89/258 (34%), Positives = 131/258 (50%), Gaps = 8/258 (3%)
Query: 57 PAD----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRA 112
PAD PL A G E +I+ G +L E N EG+ PL EAA G + +L
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 113 YPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEA 172
Q +ETA+ LA C G L+ L++AGA+ ++ TPL +A + + E
Sbjct: 523 GANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHLEL 579
Query: 173 VKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232
VK L+ A+ + G TAL + +V +L+ GA +E ++ G TPL AA+
Sbjct: 580 VKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAAR 639
Query: 233 SGQLEALRFLAKYGADIN-TQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLL 291
+G + ++FL GA++N T A+++ + L AC H VVE LL+ GAD KDG
Sbjct: 640 AGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGST 699
Query: 292 PLHIASKKGNYRIVQMLL 309
L A+K G+ +V LL
Sbjct: 700 MLIEAAKGGHTSVVCYLL 717
Score = 102 bits (255), Expect = 8e-22
Identities = 84/289 (29%), Positives = 132/289 (45%), Gaps = 32/289 (11%)
Query: 141 LSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSR 200
+S Q I + S P+Y A + + ++NH TAL + +
Sbjct: 798 ISQPQTPTPSPIISPSAMLPIYPAID----------IDAQTESNHD-----TALTLACAG 842
Query: 201 NDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASA- 259
E++Q L+ GA +E ++ G TPL +AA +G + + L GADI Q+
Sbjct: 843 GHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTP 902
Query: 260 LYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL----PVTSRT 315
L AC +EVVE LL++GA+ N PL +A+ G I+++LL + SRT
Sbjct: 903 LSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRT 962
Query: 316 RIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNN 375
+ G+SPL LAA H ++ LL D+N + E R++AL A
Sbjct: 963 G-SKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQI--------ETNRNTALTLACFQGR 1013
Query: 376 VYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDHGANIDA 421
LLL A+ + ++PL+ A G ++LLD GA+++A
Sbjct: 1014 TEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1062
Score = 97.8 bits (242), Expect = 2e-20
Identities = 74/255 (29%), Positives = 118/255 (46%), Gaps = 6/255 (2%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A G +E ++ ++ G N N + PL AA G V +K+L A I+
Sbjct: 902 PLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNA-GAEINS 960
Query: 120 RTLQEE--TAVYLATCRGHLDCLLSLLQAGAEPDIS-NKSRETPLYKACERKNAEAVKIL 176
RT + + + LA GH + LL G++ + +R T L AC + E V +L
Sbjct: 961 RTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020
Query: 177 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGI--TPLFVAAQSG 234
+ A+ HR G T L E+ S EV ++L+ GA V + T L +AA G
Sbjct: 1021 LDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALTIAADKG 1080
Query: 235 QLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLH 294
+ L GA I+ + + L+ A H +VV+ L+ GAD + + + PL
Sbjct: 1081 HYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQAGADVDAADNRKITPLM 1140
Query: 295 IASKKGNYRIVQMLL 309
A +KG+ ++V+ L+
Sbjct: 1141 AAFRKGHVKVVRYLV 1155
Score = 85.9 bits (211), Expect = 9e-17
Identities = 106/409 (25%), Positives = 166/409 (40%), Gaps = 52/409 (12%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L A ++G + +++ G +L ++ G PL +AA G V ++ L
Sbjct: 601 LTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTT 660
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
+ T + LA GHL + LL GA+P K T L +A + + V L+ +
Sbjct: 661 ANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLDYP 720
Query: 181 ADT--------------NHRCNRGWTALHESVSR---------------NDLEVMQILVS 211
+ +H NR +++ L + VS
Sbjct: 721 NNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVS 780
Query: 212 GGAKVESKN-----AYGITPLFVAAQSGQLEALRFLAKYGA-DINTQASDNA-SALYEAC 264
G A S A I+ S + L Y A DI+ Q N +AL AC
Sbjct: 781 GRASAMSNTPTHSIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLAC 840
Query: 265 KNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLP--VTSRTRIRRSGV 322
HEE+V+ LL +GA +K G PL +A+ G+ +V++LL + R+
Sbjct: 841 AGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKD 900
Query: 323 SPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELL 382
+PL LA EV+E LL+ A + R D + L A V ++L
Sbjct: 901 TPLSLACSGGRQEVVELLLARG-------ANKEHRNVSD--YTPLSLAASGGYVNIIKIL 951
Query: 383 LQHGADPNRDV-----ISPLLVAIRHGCLRTMQLLLDHGANIDAYIATH 426
L GA+ N ISPL++A +G ++LLLD G++I+A I T+
Sbjct: 952 LNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETN 1000
Score = 69.3 bits (168), Expect = 9e-12
Identities = 99/434 (22%), Positives = 165/434 (38%), Gaps = 71/434 (16%)
Query: 54 QLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAY 113
+L + PL++A ++G E +K ++ G N
Sbjct: 561 ELGCSTPLMEAAQEGHLELVKYLLAAGAN------------------------------- 589
Query: 114 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV 173
+ T +TA+ A GH D LLQAGA+ + ++ TPL KA + V
Sbjct: 590 ---VHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTV 646
Query: 174 KILVQHNADTNH-RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQ 232
+ L+ A+ N N T L + + L V+++L++ GA + G T L AA+
Sbjct: 647 QFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAK 706
Query: 233 SGQLEALRFLAKYGADI-------NTQASDNASALYEACKNEHEEVVEFLLSQGADANKT 285
G + +L Y ++ TQ + + L A + + + + Q D
Sbjct: 707 GGHTSVVCYLLDYPNNLLSAPPPDVTQLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPA 766
Query: 286 NKDGLLPLHIASKKGN-------------YRIVQMLLPVTSRTRIRRSGVSPLHLA---- 328
N LP+ + G I Q P S I S + P++ A
Sbjct: 767 NVATTLPIRNKAVSGRASAMSNTPTHSIAASISQPQTPTPSPI-ISPSAMLPIYPAIDID 825
Query: 329 --AERNHDEVLEALLSARFDVNTPLAPERARLYEDRRS---SALYFAVVNNNVYATELLL 383
E NHD L + + ER E R + L A +V E+LL
Sbjct: 826 AQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILL 885
Query: 384 QHGAD----PNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMK 439
+GAD R +PL +A G ++LLL GAN + + T P ++ +
Sbjct: 886 DNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYT--PLSLAASGG 943
Query: 440 CLSLLKFLMDLGCD 453
++++K L++ G +
Sbjct: 944 YVNIIKILLNAGAE 957
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 134 bits (338), Expect = 2e-31
Identities = 107/399 (26%), Positives = 183/399 (45%), Gaps = 48/399 (12%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL +A+ EEA++ +IK ++ +K PLH AA V C +V+ +++
Sbjct: 52 PLHRAVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLL-SSVNV 110
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
TA++ A GH++ + LL GA + +K L+ A + + V +L+ H
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A+ + +G+T LH + S + V++ L++ G +++ N YG T L +A +GQ +
Sbjct: 171 GAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVV 230
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEV-VEFLLSQGADANKTNKDGLLPLHIASK 298
L YGA++N ++ + L+ A + H + +E L++ GAD N +KDG PLH+ +
Sbjct: 231 NELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAV 290
Query: 299 KGNYRIVQML-----------------LPVTSR-------TRIRRSGVS----------P 324
G + Q L L V +R +R SG P
Sbjct: 291 HGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFP 350
Query: 325 LHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQ 384
LHLAA H + LLS+ F+++TP + + L+ A NV +LL
Sbjct: 351 LHLAALNAHSDCCRKLLSSGFEIDTP---------DKFGRTCLHAAAAGGNVECIKLLQS 401
Query: 385 HGAD---PNRDVISPLLVAIRHGCLRTMQLLLDHGANID 420
GAD ++ +PL A + ++ L+ GAN++
Sbjct: 402 SGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVN 440
Score = 123 bits (308), Expect = 5e-28
Identities = 91/312 (29%), Positives = 150/312 (48%), Gaps = 16/312 (5%)
Query: 116 TIDQRTLQEE--TAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV 173
T D TL E T +++A G + + L+ +GA + + TPL++A ++ EAV
Sbjct: 6 TEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAV 65
Query: 174 KILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQS 233
++L++H+AD N R T LH + + ++ ++++ + V + G T L AA +
Sbjct: 66 QVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALN 125
Query: 234 GQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPL 293
G +E + L GA+IN + AL+ A H +VV L++ GA+ +K G PL
Sbjct: 126 GHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPL 185
Query: 294 HIASKKGNYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLA 352
H A+ G +V+ LL + I G + LH+A D V+ L+ +VN P
Sbjct: 186 HAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQP-- 243
Query: 353 PERARLYEDRRSSALYFAVVN-NNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRT 408
+ + L+FA + + ELL+ +GAD N +D SPL + HG
Sbjct: 244 -------NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTR 296
Query: 409 MQLLLDHGANID 420
Q L+ +G ID
Sbjct: 297 SQTLIQNGGEID 308
Score = 118 bits (295), Expect = 2e-26
Identities = 111/411 (27%), Positives = 181/411 (44%), Gaps = 51/411 (12%)
Query: 74 KTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATC 133
+T+I+ G + +K+G PLH AA YG + L+ + T + + ++LA
Sbjct: 298 QTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGADTA-KCGIHSMFPLHLAAL 356
Query: 134 RGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTA 193
H DC LL +G E D +K T L+ A N E +K+L AD + + G T
Sbjct: 357 NAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTP 416
Query: 194 LHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQA 253
LH + + ++ LV+ GA V + +G T L AA S L A
Sbjct: 417 LHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGN--------A 468
Query: 254 SDNASALYEACKNEHEEV---VEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLP 310
DN+ L A + + +E +EFLL A+ + +K+G +H A+ G+ + +++LL
Sbjct: 469 HDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLE 528
Query: 311 VT-SRTRIRRSGV--SPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYED------ 361
T S SG SPLHLAA H + LE LL + D++ + E+ R D
Sbjct: 529 RTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLD--IRDEKGRTALDLAAFKG 586
Query: 362 ---------------------RRSSALYFAVVNNNVYATELLLQHGADPNRDVI------ 394
+ + L+ +V+N + LLL+ +P +
Sbjct: 587 HTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQ 646
Query: 395 SPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFA-MKCLSLL 444
+PL++A+ +G + + LLL+ AN+D TA IM +C+ +L
Sbjct: 647 TPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQML 697
Score = 105 bits (261), Expect = 2e-22
Identities = 98/370 (26%), Positives = 166/370 (44%), Gaps = 22/370 (5%)
Query: 73 LKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVL-QRAYPGTIDQRTLQEETAVYLA 131
L+ +++ N + +KEG+ +H AA YG CL++L +R G + + ++ ++LA
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549
Query: 132 TCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCN-RG 190
GH L LLQ+ + DI ++ T L A + + E V+ L+ A + N
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK 609
Query: 191 WTALHESVSRNDLEVMQILVS---GGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGA 247
T LH SV +++L+ V+ K+A G TPL +A G ++A+ L + A
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEA 669
Query: 248 DINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGN----YR 303
+++T +AL+ HEE V+ LL Q + G PLH A+ +G+
Sbjct: 670 NVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSE 729
Query: 304 IVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSA---RFDVNTPLAPERARLYE 360
++QM L G +PLH A ++ +E LL R + P P +
Sbjct: 730 LLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNPFTPLHCAIIN 789
Query: 361 DRRSSA-LYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANI 419
D + A L +++++ + D R +PL A + +QLLL H A +
Sbjct: 790 DHGNCASLLLGAIDSSIVSCR------DDKGR---TPLRAAAFADHVECLQLLLRHSAPV 840
Query: 420 DAYIATHPTA 429
+A + TA
Sbjct: 841 NAVDNSGKTA 850
Score = 98.6 bits (244), Expect = 1e-20
Identities = 97/387 (25%), Positives = 169/387 (43%), Gaps = 23/387 (5%)
Query: 41 VMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYY 100
++++ +S ++ A PL A +G +AL+ +++ +L +++G L AA+
Sbjct: 526 LLERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFK 585
Query: 101 GQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEP---DISNKSR 157
G C++ L + + + T ++ + GH CL LL+ P D+ +
Sbjct: 586 GHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKG 645
Query: 158 ETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVE 217
+TPL A + +AV +L++ A+ + G TALH + E +Q+L+ +
Sbjct: 646 QTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSIL 705
Query: 218 SKNAYGITPLFVAAQSGQ---LEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEF 274
K++ G TPL AA G L L +A D + + + L+ AC N +E +E
Sbjct: 706 CKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEV 765
Query: 275 LLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR---RSGVSPLHLAAER 331
LL Q K + PLH A + +LL + + G +PL AA
Sbjct: 766 LLEQKC-FRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFA 824
Query: 332 NHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHG-AD-- 388
+H E L+ LL VN ++ +AL A N A ++L+ AD
Sbjct: 825 DHVECLQLLLRHSAPVNA---------VDNSGKTALMMAAENGQAGAVDILVNSAQADLT 875
Query: 389 -PNRDVISPLLVAIRHGCLRTMQLLLD 414
++D+ +PL +A G + L+LD
Sbjct: 876 VKDKDLNTPLHLACSKGHEKCALLILD 902
Score = 95.1 bits (235), Expect = 2e-19
Identities = 96/387 (24%), Positives = 167/387 (43%), Gaps = 57/387 (14%)
Query: 68 GDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETA 127
G + + +I G + +K+G+ PLH AA GQ+ +K L ID+ + TA
Sbjct: 159 GHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGV-EIDEINVYGNTA 217
Query: 128 VYLATCRGHLDCLLSLLQAGAEPDISNKSRETPL-YKACERKNAEAVKILVQHNADTNHR 186
+++A G + L+ GA + N + TPL + A A +++LV + AD N +
Sbjct: 218 LHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQ 277
Query: 187 CNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYG 246
G + LH + Q L+ G +++ + G TPL VAA+ G + L G
Sbjct: 278 SKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSG 337
Query: 247 AD---------------------------------INTQASDNASALYEACKNEHEEVVE 273
AD I+T + L+ A + E ++
Sbjct: 338 ADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIK 397
Query: 274 FLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRS---GVSPLHLAAE 330
L S GAD +K +K G PLH A+ ++ ++ L VT+ + + G + LH AA
Sbjct: 398 LLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETL--VTTGANVNETDDWGRTALHYAAA 455
Query: 331 RNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADP- 389
+ D + +L D + L ERAR +++ ++ E LLQ+ A+P
Sbjct: 456 SDMDR-NKTILGNAHDNSEEL--ERARELKEKEAT-----------LCLEFLLQNDANPS 501
Query: 390 --NRDVISPLLVAIRHGCLRTMQLLLD 414
+++ + + A +G + ++LLL+
Sbjct: 502 IRDKEGYNSIHYAAAYGHRQCLELLLE 528
Score = 89.4 bits (220), Expect = 9e-18
Identities = 76/285 (26%), Positives = 133/285 (46%), Gaps = 49/285 (17%)
Query: 175 ILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSG 234
+L+ D N + T LH + D E++++L+ GA+V +K+ +TPL A S
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 235 QLEALRFLAKYGADINTQ---------------------------ASDNAS------ALY 261
EA++ L K+ AD+N + +S N S AL+
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALH 120
Query: 262 EACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RS 320
A N H E+V LL++GA+ N +K LH A+ G+ +V +L+ + + +
Sbjct: 121 HAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKK 180
Query: 321 GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATE 380
G +PLH AA V++ LL+ ++ + +Y ++AL+ A N
Sbjct: 181 GYTPLHAAASNGQINVVKHLLNLGVEI------DEINVY---GNTALHIACYNGQDAVVN 231
Query: 381 LLLQHGAD---PNRDVISPL--LVAIRHGCLRTMQLLLDHGANID 420
L+ +GA+ PN + +PL A HG L ++LL+++GA+++
Sbjct: 232 ELIDYGANVNQPNNNGFTPLHFAAASTHGAL-CLELLVNNGADVN 275
Score = 64.7 bits (156), Expect = 2e-10
Identities = 64/266 (24%), Positives = 113/266 (42%), Gaps = 39/266 (14%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL+ A+ G +A+ ++++ N+ + G LH G C+++L + +
Sbjct: 648 PLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCK 707
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQ-AGAEPDISNKSRE--TPLYKACERKNAEAVKIL 176
+ + T ++ A RGH L LLQ A +E D K + TPL+ AC N +++L
Sbjct: 708 DS-RGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVL 766
Query: 177 VQ---------------HNADTNHRCN-------------------RGWTALHESVSRND 202
++ H A N N +G T L + +
Sbjct: 767 LEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADH 826
Query: 203 LEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYG-ADINTQASDNASALY 261
+E +Q+L+ A V + + G T L +AA++GQ A+ L AD+ + D + L+
Sbjct: 827 VECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLH 886
Query: 262 EACKNEHEEVVEFLLSQGADANKTNK 287
AC HE+ +L + D + N+
Sbjct: 887 LACSKGHEKCALLILDKIQDESLINE 912
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 131 bits (329), Expect = 2e-30
Identities = 133/487 (27%), Positives = 204/487 (41%), Gaps = 54/487 (11%)
Query: 56 APADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPG 115
A PL A G +AL+ +++ +L N G PL AA+ G V C+ VL
Sbjct: 549 ATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGAS 608
Query: 116 TIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEP----DISNKSRETPLYKACERKNAE 171
+ + + + T ++ A GH +C L LL AEP DI + + +TPL + + +
Sbjct: 609 ILVKDYILKRTPIHAAATNGHSEC-LRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTD 667
Query: 172 AVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAA 231
V L+ A+ + + G TALH E + L+ GAK +++ G TP+ ++A
Sbjct: 668 CVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSA 727
Query: 232 QSGQLEALRFLAKYGA--DINTQASDN--ASALYEACKNEHEEVVEFLLSQGADANKTNK 287
G + L L + A D N +DN +AL+ AC N HE VE LL Q KT
Sbjct: 728 ACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV-FQKTEG 786
Query: 288 DGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRS---GVSPLHLAAERNHDEVLEALLSAR 344
+ PLH A N +ML+ + + + G +PLH AA +H E L+ LLS
Sbjct: 787 NAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHN 846
Query: 345 FDVN-------TPL------------------APERARLYEDRRSSALYFAVVNNNVYAT 379
VN TPL A L ++ +++AL+ A + +
Sbjct: 847 AQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSA 906
Query: 380 ELLLQHGAD------PNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPAT 433
L+L+ D N + +PL VA R+G +Q LL GA++ +A +
Sbjct: 907 LLILEKITDRNLINATNAALQTPLHVAARNGLTMVVQELLGKGASV---LAVDENGYTPA 963
Query: 434 IMFA-----MKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPS 488
+ A CL+L+ M P S + + F P EPS
Sbjct: 964 LACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRNEPS 1023
Query: 489 VVQFCEF 495
+C F
Sbjct: 1024 --SYCSF 1028
Score = 117 bits (294), Expect = 2e-26
Identities = 98/365 (26%), Positives = 163/365 (44%), Gaps = 48/365 (13%)
Query: 61 LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQR 120
L++AI +GD + ++ +I + +++ + E PLH AAY G +++
Sbjct: 12 LVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIEL------------ 59
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
L+ +GA + + TPL++A + EAV++L++H+
Sbjct: 60 ----------------------LILSGARVNAKDSKWLTPLHRAVASCSEEAVQVLLKHS 97
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
AD N R T LH + + ++ + LV + V + G T L AA SG E ++
Sbjct: 98 ADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVK 157
Query: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKG 300
L GA+IN + A++ A H EVV+ L+S GA+ +K PLH A+ G
Sbjct: 158 LLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSG 217
Query: 301 NYRIVQMLLPV-TSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLY 359
+V+ LL + G +PLH+A D V+ L+ VN
Sbjct: 218 MISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQK--------- 268
Query: 360 EDRRSSALYFAVVN-NNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTMQLLLDH 415
++ + L+FA + + ELL+ +GAD N +D +PL + HG Q ++
Sbjct: 269 NEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQS 328
Query: 416 GANID 420
GA ID
Sbjct: 329 GAVID 333
Score = 117 bits (293), Expect = 3e-26
Identities = 109/432 (25%), Positives = 194/432 (44%), Gaps = 32/432 (7%)
Query: 37 LFQGVMQKYSSSLFKTSQLAPAD-----PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGW 91
+F G + + +FK + D PL A GD E ++ +I G + + +
Sbjct: 16 IFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWL 75
Query: 92 LPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPD 151
PLH A ++VL + + ++ R +T +++A + C +L+ + +
Sbjct: 76 TPLHRAVASCSEEAVQVLLK-HSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVN 134
Query: 152 ISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVS 211
+S+++ T L+ A + E VK+L+ A+ N + A+H + +EV+++LVS
Sbjct: 135 VSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVS 194
Query: 212 GGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEV 271
GA+V K+ TPL AA SG + +++L G D+N + + L+ AC N + V
Sbjct: 195 HGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVV 254
Query: 272 VEFLLSQGADANKTNKDGLLPLHIASKKGNYRI-VQMLLPVTSRTRIR-RSGVSPLHLAA 329
V L+ GA N+ N+ G PLH A+ + + +++L+ + ++ + G +PLH+ A
Sbjct: 255 VNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTA 314
Query: 330 ERNHDEVLEALLSARFDVNTPLAPERARL-YEDRR-SSALYFAVVNNNVYATELLLQHGA 387
L RF + + A + ED+ ++ L+ A + L+ GA
Sbjct: 315 -----------LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA 363
Query: 388 DPNRDVIS---PLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKC---L 441
D + I PL +A G + LL G +ID P F T + A L
Sbjct: 364 DTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDT-----PDDFGRTCLHAAAAGGNL 418
Query: 442 SLLKFLMDLGCD 453
L L++ G D
Sbjct: 419 ECLNLLLNTGAD 430
Score = 108 bits (269), Expect = 2e-23
Identities = 104/397 (26%), Positives = 180/397 (45%), Gaps = 14/397 (3%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAY--YGQVGCLKVLQRAYPGTI 117
PL A +G + + +I G + + N++G+ PLH AA +G + CL++L +
Sbjct: 242 PLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGAL-CLELLV-GNGADV 299
Query: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
+ ++ +T +++ G +++Q+GA D +K+ TPL+ A + + L+
Sbjct: 300 NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
ADT R G LH + + + L+S G +++ + +G T L AA G LE
Sbjct: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLE 419
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
L L GAD N + S L+ A N + + + L+ GA N ++ G PLH A+
Sbjct: 420 CLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAA 479
Query: 298 KKG-NYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEALLS-ARFDVNTPLAPE 354
+ + ++ LL + IR + G + +H +A H L+ + S DV +
Sbjct: 480 TSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGT 539
Query: 355 RARLYEDRRS--SALYFAVVNNNVYATELLLQHGAD---PNRDVISPLLVAIRHGCLRTM 409
D R+ S L+ A + + A E+L+Q D N +PL +A G + +
Sbjct: 540 DMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECV 599
Query: 410 QLLLDHGANI--DAYIATHPTAFPATIMFAMKCLSLL 444
+L++ GA+I YI A +CL LL
Sbjct: 600 DVLINQGASILVKDYILKRTPIHAAATNGHSECLRLL 636
Score = 37.7 bits (86), Expect = 0.030
Identities = 33/160 (20%), Positives = 66/160 (41%), Gaps = 3/160 (1%)
Query: 36 GLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLH 95
G + ++ +S+ + PL A E L+ ++ + + G PL
Sbjct: 802 GAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLM 861
Query: 96 EAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI--- 152
AA GQ +++L + + + + TA++LA +GH L +L+ + ++
Sbjct: 862 MAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINA 921
Query: 153 SNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWT 192
+N + +TPL+ A V+ L+ A G+T
Sbjct: 922 TNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYT 961
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 128 bits (321), Expect = 2e-29
Identities = 87/287 (30%), Positives = 145/287 (50%), Gaps = 6/287 (2%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAY--YGQVGCLKVLQRAYPGTI 117
PL A ++GD+ + ++ G + +EGW PLH AA + V L V ++A P
Sbjct: 431 PLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLH 490
Query: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV 177
+ + +T +++A GH+ + L GAE D ++ TPL+ A ER A++ L+
Sbjct: 491 EA---EGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547
Query: 178 QHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLE 237
+ A + G+ LH + +R + ++L+ GA +E G TPL +AA G LE
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLE 607
Query: 238 ALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIAS 297
+ LA+ A++ + N + L+ A ++ E VV LL GAD N + G PLH+A
Sbjct: 608 IIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAV 667
Query: 298 KKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLEALLSA 343
++ + V LL + R + G +P HLAA + + +L+ L+ A
Sbjct: 668 QRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEA 714
Score = 122 bits (305), Expect = 1e-27
Identities = 103/374 (27%), Positives = 170/374 (45%), Gaps = 21/374 (5%)
Query: 93 PLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDI 152
PLH G V +++L A+ +D +T T + +A D LL GA+ +
Sbjct: 365 PLHFLVAQGSVEQVRLLL-AHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANR 423
Query: 153 SNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSG 212
++ PL+ A + + ++L+ H A + + GWT LH + N V ++LVS
Sbjct: 424 VDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSR 483
Query: 213 GAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVV 272
A A G TPL VAA G + ++ L GA+++ Q + + L+ A + +
Sbjct: 484 QADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAI 543
Query: 273 EFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAER 331
+ LL GA + ++ G PLH A+ +G Y I +MLL + + G +PLHLAA +
Sbjct: 544 QHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYK 603
Query: 332 NHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN- 390
H E++ L + ++ A + L+ A + LLQ GADPN
Sbjct: 604 GHLEIIHLLAESHANMGALGAV---------NWTPLHLAARHGEEAVVSALLQCGADPNA 654
Query: 391 --RDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLM 448
+ +PL +A++ ++ LL+H AN+ A T PA + ++LK L+
Sbjct: 655 AEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWT--PAHLAALKGNTAILKVLV 712
Query: 449 DLGC-----DGEPC 457
+ G DG C
Sbjct: 713 EAGAQLDVQDGVSC 726
Score = 95.1 bits (235), Expect = 2e-19
Identities = 73/278 (26%), Positives = 130/278 (46%), Gaps = 13/278 (4%)
Query: 155 KSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGA 214
+++ TPL+ + + E V++L+ H D + + G+T L + ++ +L++ GA
Sbjct: 360 ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGA 419
Query: 215 KVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEF 274
+ G PL AAQ+G R L +GA ++ Q + + L+ A +N E V
Sbjct: 420 DANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARL 479
Query: 275 LLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGV-SPLHLAAERNH 333
L+S+ AD N +G PLH+A+ G+ +V++L + ++ + +PLHLA ER
Sbjct: 480 LVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGK 539
Query: 334 DEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD---PN 390
++ LL + P+ + L+ A ++LL++GA P
Sbjct: 540 VRAIQHLL------KSGAVPD---ALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPT 590
Query: 391 RDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPT 428
+PL +A G L + LL + AN+ A A + T
Sbjct: 591 HQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWT 628
Score = 92.8 bits (229), Expect = 8e-19
Identities = 64/216 (29%), Positives = 105/216 (48%), Gaps = 1/216 (0%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A++ G A++ ++K G ++ G+ PLH AA G+ K+L R Y +++
Sbjct: 530 PLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLR-YGASLEL 588
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
T Q T ++LA +GHL+ + L ++ A TPL+ A V L+Q
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC 648
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
AD N GWT LH +V R+ + L+ A V ++N G TP +AA G L
Sbjct: 649 GADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAIL 708
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFL 275
+ L + GA ++ Q + + L A ++ + ++ FL
Sbjct: 709 KVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFL 744
Score = 77.8 bits (190), Expect = 3e-14
Identities = 80/319 (25%), Positives = 129/319 (40%), Gaps = 76/319 (23%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPN---KEGWLPLHEAAYYGQVGCLKVLQRAYPGT 116
PL A ++ E + ++ A+PN EG PLH AAY+G V +K+L +
Sbjct: 464 PLHLAAQNNFENVARLLVSRQ---ADPNLHEAEGKTPLHVAAYFGHVSLVKLLT-SQGAE 519
Query: 117 IDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKIL 176
+D + T ++LA RG + + LL++GA PD ++S PL+ A R K+L
Sbjct: 520 LDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKML 579
Query: 177 VQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSG------------------------ 212
+++ A ++GWT LH + + LE++ +L
Sbjct: 580 LRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEE 639
Query: 213 ---------GAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEA 263
GA + G TPL +A Q FL+
Sbjct: 640 AVVSALLQCGADPNAAEQSGWTPLHLAVQRS-----TFLS-------------------- 674
Query: 264 CKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVS 323
V LL A+ + NK G P H+A+ KGN I+++L+ ++ + + GVS
Sbjct: 675 --------VINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDV-QDGVS 725
Query: 324 --PLHLAAERNHDEVLEAL 340
PL LA ++ L
Sbjct: 726 CTPLQLALRSRKQGIMSFL 744
Score = 48.9 bits (115), Expect = 1e-05
Identities = 45/135 (33%), Positives = 61/135 (45%), Gaps = 19/135 (14%)
Query: 297 SKKGNY--RIVQM-----LLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNT 349
S GNY R +Q+ L+P I + V+PLH + E + LL+ DV+
Sbjct: 331 SDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDC 390
Query: 350 PLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNR---DVISPLLVAIRHGCL 406
A + L A + LLL HGAD NR D +PL A ++G
Sbjct: 391 QTA---------SGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDD 441
Query: 407 RTMQLLLDHGANIDA 421
T +LLLDHGA +DA
Sbjct: 442 GTARLLLDHGACVDA 456
>gi|70995267 ankyrin repeat domain 29 [Homo sapiens]
Length = 301
Score = 123 bits (308), Expect = 5e-28
Identities = 79/258 (30%), Positives = 128/258 (49%), Gaps = 4/258 (1%)
Query: 93 PLHEAAYY----GQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGA 148
PL AA++ G + LK+L + +D R T + +A GH+DC+ L+ GA
Sbjct: 11 PLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGA 70
Query: 149 EPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQI 208
+ ++ +S T L+ A ++ + + V+ L A T R G TAL + ++V++
Sbjct: 71 DINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVET 130
Query: 209 LVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEH 268
L+ GA + + G T LF+AAQ G L+ +R L GA +N D + L+ A + H
Sbjct: 131 LLKHGANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGH 190
Query: 269 EEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLA 328
EVV +L +GAD + DG L A+ KG +++ LL + I ++G S LH A
Sbjct: 191 SEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAA 250
Query: 329 AERNHDEVLEALLSARFD 346
+ + + LL A D
Sbjct: 251 VLSGNIKTVALLLEAGAD 268
Score = 120 bits (301), Expect = 3e-27
Identities = 87/266 (32%), Positives = 137/266 (51%), Gaps = 12/266 (4%)
Query: 127 AVYLATCRGHLDCLLSLLQAG-AEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNH 185
A + A RG+L L LL +G + D + T L A + + V+ LV AD N
Sbjct: 15 AAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADINL 74
Query: 186 RCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKY 245
+ G TAL + + +V++ L GA E + G T L A+Q G ++ + L K+
Sbjct: 75 QRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKH 134
Query: 246 GADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIV 305
GA+I+ Q D A+AL+ A + + +V+ LL+ GA N+ +DG PL IAS+ G+ +V
Sbjct: 135 GANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVV 194
Query: 306 Q-MLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRS 364
+ MLL R R G + L AA + +++V++ LL +P L +
Sbjct: 195 RVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLK--------FSPTLGILKNG--T 244
Query: 365 SALYFAVVNNNVYATELLLQHGADPN 390
SAL+ AV++ N+ LLL+ GADP+
Sbjct: 245 SALHAAVLSGNIKTVALLLEAGADPS 270
Score = 88.2 bits (217), Expect = 2e-17
Identities = 74/280 (26%), Positives = 126/280 (45%), Gaps = 41/280 (14%)
Query: 64 AIKDGDEEALKTMIKEGK-NLAEPNKEGWLPLHEAAYYGQVGCLK--VLQRAYPGTIDQR 120
A + G+ LK ++ G+ ++ + G L AAY G + C++ VLQ A I+ +
Sbjct: 19 AARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGA---DINLQ 75
Query: 121 TLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHN 180
TA++ A +GH D + L GA + K T L A + + + V+ L++H
Sbjct: 76 RESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVETLLKHG 135
Query: 181 ADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALR 240
A+ + + G TAL + L+V+++L++ GAKV G PL++A+Q G E +R
Sbjct: 136 ANIHDQLYDGATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTAPLWIASQMGHSEVVR 195
Query: 241 FLAKYGADINTQASDNASALYEACKNEHEEVVE--------------------------- 273
+ GAD + +D +AL +A + +V++
Sbjct: 196 VMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGILKNGTSALHAAVLSGN 255
Query: 274 -----FLLSQGADANKTNKDGLLPLHIASKKGNYRIVQML 308
LL GAD + NK LP + N RI+++L
Sbjct: 256 IKTVALLLEAGADPSLRNKANELPAELTK---NERILRLL 292
Score = 68.2 bits (165), Expect = 2e-11
Identities = 60/206 (29%), Positives = 100/206 (48%), Gaps = 18/206 (8%)
Query: 225 TPL----FVAAQSGQLEALRFLAKYG-ADINTQASDNASALYEACKNEHEEVVEFLLSQG 279
TPL F AA+ G L L+ L G D++ + S + L A H + V L+ QG
Sbjct: 10 TPLANAAFWAARRGNLALLKLLLNSGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQG 69
Query: 280 ADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIR-RSGVSPLHLAAERNHDEVLE 338
AD N + G L A+++G+ +V+ L + T R + G + L A++ H +V+E
Sbjct: 70 ADINLQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVVE 129
Query: 339 ALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGA---DPNRDVIS 395
LL +++ +LY+ ++AL+ A + LLL GA P +D +
Sbjct: 130 TLLKHGANIHD-------QLYDG--ATALFLAAQGGYLDVIRLLLASGAKVNQPRQDGTA 180
Query: 396 PLLVAIRHGCLRTMQLLLDHGANIDA 421
PL +A + G ++++L GA+ DA
Sbjct: 181 PLWIASQMGHSEVVRVMLLRGADRDA 206
Score = 42.0 bits (97), Expect = 0.002
Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 6/103 (5%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYP--GTI 117
PL A + G E ++ M+ G + +G L +AA G +K L + P G +
Sbjct: 181 PLWIASQMGHSEVVRVMLLRGADRDAARNDGTTALLKAANKGYNDVIKELLKFSPTLGIL 240
Query: 118 DQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETP 160
T +A++ A G++ + LL+AGA+P + NK+ E P
Sbjct: 241 KNGT----SALHAAVLSGNIKTVALLLEAGADPSLRNKANELP 279
Score = 39.7 bits (91), Expect = 0.008
Identities = 36/140 (25%), Positives = 65/140 (46%), Gaps = 16/140 (11%)
Query: 296 ASKKGNYRIVQMLLPVTSRTRIR---RSGVSPLHLAAERNHDEVLEALLSARFDVNTPLA 352
A+++GN ++++LL + R + G + L +AA H + + L+ D+N
Sbjct: 19 AARRGNLALLKLLLN-SGRVDVDCRDSHGTTLLMVAAYAGHIDCVRELVLQGADIN---- 73
Query: 353 PERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPN---RDVISPLLVAIRHGCLRTM 409
L + ++AL+FA + L GA +D + LL A ++G ++ +
Sbjct: 74 -----LQRESGTTALFFAAQQGHNDVVRFLFGFGASTEFRTKDGGTALLAASQYGHMQVV 128
Query: 410 QLLLDHGANIDAYIATHPTA 429
+ LL HGANI + TA
Sbjct: 129 ETLLKHGANIHDQLYDGATA 148
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 122 bits (307), Expect = 7e-28
Identities = 85/285 (29%), Positives = 136/285 (47%), Gaps = 14/285 (4%)
Query: 106 LKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKAC 165
+K+LQ P +D + ++LA G +C LL A P++SN+ TPL+ A
Sbjct: 423 MKILQ---PQDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAV 479
Query: 166 ERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGIT 225
ER+ V++L+ N + WTALH + D ++L+ A V + G T
Sbjct: 480 ERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRT 539
Query: 226 PLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQ-GADANK 284
P+ VA Q GQ +R L + G D++ Q D L+ A H +V+ L Q G N
Sbjct: 540 PMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNA 599
Query: 285 TNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRI-RRSGVSPLHLAAERNHDEVLEALLSA 343
DG PLH+A+++G+YR+ ++L+ + S + +PLH+AAE H LL
Sbjct: 600 QTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHR 659
Query: 344 RFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGAD 388
A + A + +AL+ A N ++ +LL++ AD
Sbjct: 660 G-------AGKEAMTSDG--YTALHLAARNGHLATVKLLVEEKAD 695
Score = 121 bits (303), Expect = 2e-27
Identities = 89/329 (27%), Positives = 150/329 (45%), Gaps = 13/329 (3%)
Query: 64 AIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQ 123
A++ G EE K ++ N N+ G PLH A G +++L A +++ +
Sbjct: 445 AVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLL-ARKISVNAKDED 503
Query: 124 EETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADT 183
+ TA++ A G LL+ A + + TP++ AC+ V+IL++ D
Sbjct: 504 QWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDV 563
Query: 184 NHRCNRGWTALHESVSRNDLEVMQILVSG-GAKVESKNAYGITPLFVAAQSGQLEALRFL 242
+ + W LH + + L ++++L G V ++ G TPL +AAQ G R L
Sbjct: 564 SLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARIL 623
Query: 243 AKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNY 302
+D+N + + L+ A + H LL +GA DG LH+A++ G+
Sbjct: 624 IDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHL 683
Query: 303 RIVQMLLPVTSRTRIRRS-GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYED 361
V++L+ + R + LHLAA H EV+E L+SA + L+++
Sbjct: 684 ATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEELVSA----------DVIDLFDE 733
Query: 362 RRSSALYFAVVNNNVYATELLLQHGADPN 390
+ SAL+ A + E LL+HGA N
Sbjct: 734 QGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 105 bits (262), Expect = 1e-22
Identities = 108/414 (26%), Positives = 167/414 (40%), Gaps = 48/414 (11%)
Query: 24 APPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNL 83
+PPE P L + + + + L+ D + +G EE ++ +
Sbjct: 305 SPPEPRSEVVPARLKRASAPTFDNDYSLSELLSQLDSGVSQAVEGPEELSRSSSESKLPS 364
Query: 84 AEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQ-EETAVYLATCRGHLDCLLS 142
+ K + + G L + P T D T ++ + A G L+
Sbjct: 365 SGSGKRLSGVSSVDSAFSSRGSLSLSFEREPSTSDLGTTDVQKKKLVDAIVSGDTSKLMK 424
Query: 143 LLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRND 202
+LQ + D++ S + L+ A E E K L+ +NA+ N RG T LH +V R
Sbjct: 425 ILQP-QDVDLALDSGASLLHLAVEAGQEECAKWLLLNNANPNLSNRRGSTPLHMAVERRV 483
Query: 203 LEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYE 262
V+++L++ V +K+ T L AAQ+G + R L + A +N + + ++
Sbjct: 484 RGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHV 543
Query: 263 ACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL--PVTSRTRIRRS 320
AC++ E +V LL +G D + KD LPLH A+ +G+ IV++L P S
Sbjct: 544 ACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLD 603
Query: 321 GVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATE 380
G +PLHLAA+R H V L+ DVN
Sbjct: 604 GRTPLHLAAQRGHYRVARILIDLCSDVNV-----------------------------CS 634
Query: 381 LLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGA-----NIDAYIATHPTA 429
LL Q +PL VA G T +LLL GA D Y A H A
Sbjct: 635 LLAQ----------TPLHVAAETGHTSTARLLLHRGAGKEAMTSDGYTALHLAA 678
Score = 100 bits (249), Expect = 4e-21
Identities = 62/224 (27%), Positives = 110/224 (49%), Gaps = 1/224 (0%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
P+ A + G E ++ +++ G +++ K+ WLPLH AA+ G + +K+L + +++
Sbjct: 540 PMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNA 599
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQH 179
+TL T ++LA RGH L+ ++ ++ + +TPL+ A E + ++L+
Sbjct: 600 QTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHR 659
Query: 180 NADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEAL 239
A + G+TALH + L +++LV A V ++ T L +AA G E +
Sbjct: 660 GAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVV 719
Query: 240 RFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADAN 283
L I+ SAL+ A + H + VE LL GA N
Sbjct: 720 EELVSADV-IDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
Score = 98.6 bits (244), Expect = 1e-20
Identities = 74/290 (25%), Positives = 129/290 (44%), Gaps = 2/290 (0%)
Query: 60 PLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQ 119
PL A++ ++ ++ ++ +++ W LH AA G ++L ++++
Sbjct: 474 PLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKN-ASVNE 532
Query: 120 RTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILV-Q 178
+ T +++A G + + LL+ G + + K PL+ A + + VK+L Q
Sbjct: 533 VDFEGRTPMHVACQHGQENIVRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQ 592
Query: 179 HNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEA 238
N + G T LH + R V +IL+ + V + TPL VAA++G
Sbjct: 593 PGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAETGHTST 652
Query: 239 LRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASK 298
R L GA SD +AL+ A +N H V+ L+ + AD LH+A+
Sbjct: 653 ARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAA 712
Query: 299 KGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVN 348
G+ +V+ L+ G+S LHLAA+ H + +E LL +N
Sbjct: 713 HGHSEVVEELVSADVIDLFDEQGLSALHLAAQGRHAQTVETLLRHGAHIN 762
>gi|58331113 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 122 bits (305), Expect = 1e-27
Identities = 104/353 (29%), Positives = 158/353 (44%), Gaps = 27/353 (7%)
Query: 57 PADP--LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYP 114
P DP L + +++G ALK ++ P G LH AA +G L L A+
Sbjct: 4 PGDPRRLCRLVQEGRLRALKEELQAAGGC--PGPAGDTLLHCAARHGHRDVLAYLAEAWG 61
Query: 115 GTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVK 174
I+ + ++ A GH DC+ LL GA D K+ TPL AC RKN ++
Sbjct: 62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQ 121
Query: 175 ILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVS---GGAKVESKNAYGITPLFVAA 231
LV+H A+ + GW + H + D ++Q L++ G K ESK TPL AA
Sbjct: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESK--IRRTPLHTAA 179
Query: 232 QSGQLEALRFLAK---YGADINTQASDNASALYEACKNEHEEVVEFLLSQ-GADANKTNK 287
G LEA++ L K Y D +AL +A + H +V LL + GA + +
Sbjct: 180 MHGHLEAVKVLLKRCQYEPDYRDNC--GVTALMDAIQCGHIDVARLLLDEHGACLSAEDS 237
Query: 288 DGLLPLHIASKKGNYRIVQML---LPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSAR 344
G LH A+ G ++ L L V R + ++ LH AA+ H ++ LLS
Sbjct: 238 LGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLG 297
Query: 345 FDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPL 397
D+N+ +++ SAL+ A ++ + LLQ G + D+ L
Sbjct: 298 ADINSK---------DEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTL 341
>gi|58331111 ankyrin repeat domain 16 isoform a [Homo sapiens]
Length = 361
Score = 122 bits (305), Expect = 1e-27
Identities = 104/353 (29%), Positives = 158/353 (44%), Gaps = 27/353 (7%)
Query: 57 PADP--LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYP 114
P DP L + +++G ALK ++ P G LH AA +G L L A+
Sbjct: 4 PGDPRRLCRLVQEGRLRALKEELQAAGGC--PGPAGDTLLHCAARHGHRDVLAYLAEAWG 61
Query: 115 GTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVK 174
I+ + ++ A GH DC+ LL GA D K+ TPL AC RKN ++
Sbjct: 62 MDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAAVDCLKKADWTPLMMACTRKNLGVIQ 121
Query: 175 ILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVS---GGAKVESKNAYGITPLFVAA 231
LV+H A+ + GW + H + D ++Q L++ G K ESK TPL AA
Sbjct: 122 ELVEHGANPLLKNKDGWNSFHIASREGDPLILQYLLTVCPGAWKTESK--IRRTPLHTAA 179
Query: 232 QSGQLEALRFLAK---YGADINTQASDNASALYEACKNEHEEVVEFLLSQ-GADANKTNK 287
G LEA++ L K Y D +AL +A + H +V LL + GA + +
Sbjct: 180 MHGHLEAVKVLLKRCQYEPDYRDNC--GVTALMDAIQCGHIDVARLLLDEHGACLSAEDS 237
Query: 288 DGLLPLHIASKKGNYRIVQML---LPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSAR 344
G LH A+ G ++ L L V R + ++ LH AA+ H ++ LLS
Sbjct: 238 LGAQALHRAAVTGQDEAIRFLVSELGVDVDVRATSTHLTALHYAAKEGHTSTIQTLLSLG 297
Query: 345 FDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPL 397
D+N+ +++ SAL+ A ++ + LLQ G + D+ L
Sbjct: 298 ADINSK---------DEKNRSALHLACAGQHLACAKFLLQSGLKDSEDITGTL 341
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,199,635
Number of Sequences: 37866
Number of extensions: 1077702
Number of successful extensions: 8976
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 334
Number of HSP's successfully gapped in prelim test: 50
Number of HSP's that attempted gapping in prelim test: 3467
Number of HSP's gapped (non-prelim): 2164
length of query: 587
length of database: 18,247,518
effective HSP length: 108
effective length of query: 479
effective length of database: 14,157,990
effective search space: 6781677210
effective search space used: 6781677210
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.