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Search of human proteins with 18079216
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18079216 CASK interacting protein 1 [Homo sapiens]
(1431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18079216 CASK interacting protein 1 [Homo sapiens] 2890 0.0
gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens] 865 0.0
gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens] 763 0.0
gi|50511945 cajalin 2 isoform a [Homo sapiens] 206 1e-52
gi|140161500 ankyrin repeat and sterile alpha motif domain conta... 189 2e-47
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 124 6e-28
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 124 8e-28
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 124 8e-28
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 124 8e-28
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 124 8e-28
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 124 8e-28
gi|163965366 nascent polypeptide-associated complex alpha subuni... 121 5e-27
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 120 7e-27
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 120 7e-27
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 120 7e-27
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 119 2e-26
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 119 2e-26
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 116 2e-25
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 115 4e-25
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 115 4e-25
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 114 5e-25
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 114 7e-25
gi|153792074 proline rich 12 [Homo sapiens] 113 1e-24
gi|89363047 death-associated protein kinase 1 [Homo sapiens] 112 2e-24
gi|34304381 inversin isoform a [Homo sapiens] 111 4e-24
gi|34304379 inversin isoform b [Homo sapiens] 111 4e-24
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 111 6e-24
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 110 1e-23
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ... 110 1e-23
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 108 5e-23
>gi|18079216 CASK interacting protein 1 [Homo sapiens]
Length = 1431
Score = 2890 bits (7491), Expect = 0.0
Identities = 1431/1431 (100%), Positives = 1431/1431 (100%)
Query: 1 MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNG 60
MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNG
Sbjct: 1 MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNG 60
Query: 61 NTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLH 120
NTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLH
Sbjct: 61 NTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLH 120
Query: 121 LAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPR 180
LAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPR
Sbjct: 121 LAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPR 180
Query: 181 PGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLL 240
PGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLL
Sbjct: 181 PGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLL 240
Query: 241 LDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTS 300
LDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTS
Sbjct: 241 LDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTS 300
Query: 301 LNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIVKRAGSRAGTEPSLP 360
LNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIVKRAGSRAGTEPSLP
Sbjct: 301 LNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIVKRAGSRAGTEPSLP 360
Query: 361 QGSSSSGPSAPPEEIWVLRKPFAGGDRSGSISGMAGGRGSGGHALHAGSEGVKLLATVLS 420
QGSSSSGPSAPPEEIWVLRKPFAGGDRSGSISGMAGGRGSGGHALHAGSEGVKLLATVLS
Sbjct: 361 QGSSSSGPSAPPEEIWVLRKPFAGGDRSGSISGMAGGRGSGGHALHAGSEGVKLLATVLS 420
Query: 421 QKSVSESGPGDSPAKPPEGSAGVARSQPPVAHAGQVYGEQPPKKLEPASEGKSSEAVSQW 480
QKSVSESGPGDSPAKPPEGSAGVARSQPPVAHAGQVYGEQPPKKLEPASEGKSSEAVSQW
Sbjct: 421 QKSVSESGPGDSPAKPPEGSAGVARSQPPVAHAGQVYGEQPPKKLEPASEGKSSEAVSQW 480
Query: 481 LTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWLPE 540
LTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWLPE
Sbjct: 481 LTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWLPE 540
Query: 541 HKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVR 600
HKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVR
Sbjct: 541 HKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVR 600
Query: 601 KLAELQKAEYAKYEGGPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDE 660
KLAELQKAEYAKYEGGPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDE
Sbjct: 601 KLAELQKAEYAKYEGGPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDE 660
Query: 661 LQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSP 720
LQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSP
Sbjct: 661 LQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSP 720
Query: 721 MSRSQEYLLDEGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTP 780
MSRSQEYLLDEGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTP
Sbjct: 721 MSRSQEYLLDEGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTP 780
Query: 781 TKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPV 840
TKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPV
Sbjct: 781 TKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPV 840
Query: 841 EGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLV 900
EGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLV
Sbjct: 841 EGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLV 900
Query: 901 PAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASA 960
PAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASA
Sbjct: 901 PAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASA 960
Query: 961 NLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAA 1020
NLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAA
Sbjct: 961 NLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAA 1020
Query: 1021 RRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRG 1080
RRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRG
Sbjct: 1021 RRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRG 1080
Query: 1081 PGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKF 1140
PGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKF
Sbjct: 1081 PGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKF 1140
Query: 1141 ILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEP 1200
ILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEP
Sbjct: 1141 ILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEP 1200
Query: 1201 PPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEV 1260
PPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEV
Sbjct: 1201 PPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEV 1260
Query: 1261 KRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPS 1320
KRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPS
Sbjct: 1261 KRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPS 1320
Query: 1321 LGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACL 1380
LGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACL
Sbjct: 1321 LGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACL 1380
Query: 1381 AAALQAVEEKIRQEDAQGPRDSAAEKSTGSILDDIGSMFDDLADQLDAMLE 1431
AAALQAVEEKIRQEDAQGPRDSAAEKSTGSILDDIGSMFDDLADQLDAMLE
Sbjct: 1381 AAALQAVEEKIRQEDAQGPRDSAAEKSTGSILDDIGSMFDDLADQLDAMLE 1431
>gi|217416347 cask-interacting protein 2 isoform a [Homo sapiens]
Length = 1202
Score = 865 bits (2236), Expect = 0.0
Identities = 615/1475 (41%), Positives = 763/1475 (51%), Gaps = 317/1475 (21%)
Query: 1 MGKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNG 60
MG+EQ+L+ AVK DV Q+L+ + + K KLLGSTK++NVN+QD DGFSALHHAAL G
Sbjct: 1 MGREQDLILAVKNGDVTGVQKLVAKVKATKTKLLGSTKRLNVNYQDADGFSALHHAALGG 60
Query: 61 NTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLH 120
+ ELI+LLLEAQA VDIKD+ GMRPLHYAAWQGR EP++L+L+A +AVN S +G IPLH
Sbjct: 61 SLELIALLLEAQATVDIKDSNGMRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLH 120
Query: 121 LAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPR 180
LAAQ+GHY+VSEMLLQHQSNPC+V+ + KTPLDLACEFGR+ V QLLL+S++C ALLE
Sbjct: 121 LAAQYGHYEVSEMLLQHQSNPCLVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGE 180
Query: 181 PGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLL 240
D DPN T+PLHLAAKNGH ++IR LL+AGI+INRQTK+GTALHEAAL GKTEVVRLL
Sbjct: 181 AKDPCDPNYTTPLHLAAKNGHREVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLL 240
Query: 241 LDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTS 300
L+ G++ ++RNTY+QTALDIV+QFTTSQASREIKQLLREAS L+VRA KD+ N +D T+
Sbjct: 241 LEGGVDVNIRNTYNQTALDIVNQFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTA 300
Query: 301 LNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPSSLGEAIVKRAGSRAGTEPSLP 360
LNV+AGD+ITVLEQHPDGRWKG IH+++ G DR+GYFP + E + KR G A PS P
Sbjct: 301 LNVRAGDVITVLEQHPDGRWKGHIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAP 360
Query: 361 QG-----SSSSGPSA--PPEEIWVLRKPFAGGDRSGSISGMAGGRGSGGHALHAGSEGVK 413
S + P A PP + + P G S AG R S G GS ++
Sbjct: 361 TPLRPGFSRTPQPPAEEPPHPLTYSQLPRVG----LSPDSPAGDRNSVGSEGSVGS--IR 414
Query: 414 LLATVLSQKSVSESGPG----DSPAKPPEGSAGVARSQPPVAHAGQV---------YGEQ 460
+ S + + GPG ++ P G V P + A + GEQ
Sbjct: 415 SAGSGQSSEGTNGHGPGLLIENAQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQ 474
Query: 461 ---PPKKLEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVT 517
+ E EGK ++A+ WL+ FQL+ Y +F+ AGYD+PTISRMTPEDLTAIGVT
Sbjct: 475 IFTQDVRPEQLLEGKDAQAIHNWLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVT 534
Query: 518 KPGHRKKIAAEISGLSIPDWLPEHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDIT 577
KPGHRKKIA+EI+ LSI +WLP + P +L WL +GL QY+K LV +GY+++ + D+T
Sbjct: 535 KPGHRKKIASEIAQLSIAEWLPSYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLT 594
Query: 578 WEDLQEIGITKLGHQKKLMLAVRKLAELQKA---EYAKYEGGPLRRKAPQSLEVMAIESP 634
WE+LQEIG+ KLGHQKKLML V++LAEL++ A EGG K P+ + + +E+
Sbjct: 595 WEELQEIGVNKLGHQKKLMLGVKRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENG 654
Query: 635 PPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDS 694
P P++ TFQ SELS ELQAAM G GP P P A +
Sbjct: 655 EGPATA-----GPRLLTFQGSELSPELQAAMAGG---GPEP-------LPLPPARSPSQE 699
Query: 695 SLGGRARHMSSSQELLGDGPPG--PSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSIK 752
S+G R+R SQE P G PS P R+ L EG PP K
Sbjct: 700 SIGARSRGSGHSQEQPAPQPSGGDPSPPQERN----LPEGTE--RPP------------K 741
Query: 753 RASVPPVPGKPRQVL--PPGTSHFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQL 810
S P G P V P G+ P P PG+P A GP PAT
Sbjct: 742 LCSSLPGQGPPPYVFMYPQGSPSSPAPGPP----PGAPWAFSYLAGP-PAT--------- 787
Query: 811 LPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEAD 870
PP P P R + P P EG+ A GP
Sbjct: 788 -PPD---------PPRPKRRSHSLSRPGPTEGDAEGEAEGPV------------------ 819
Query: 871 AEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNV 930
+L YA P R L+ R+ P A +
Sbjct: 820 ---------GSTLGSYATLTRRPGRSALV----------------RTSPSVTPTPA-RGT 853
Query: 931 NRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAE---PEDGLLGVRAQCRRAS 987
RSQSFA+R R+KGPPPPPPKR SS + + EP P E P++G G R R S
Sbjct: 854 PRSQSFALRARRKGPPPPPPKRLSSV---SGPSPEPPPLDESPGPKEGATGPRR--RTLS 908
Query: 988 DLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASV 1047
+ AG P E P PA P AS
Sbjct: 909 EPAG-------------------------------PSEPPGPPAPAGP---------ASD 928
Query: 1048 KHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPGESADPGPFVEDG--TGRQRPR--GP 1103
+E GP G +R G S + PF E+G T +QRP+ GP
Sbjct: 929 TEEEEPGPEGTPPSR-------------------GSSGEGLPFAEEGNLTIKQRPKPAGP 969
Query: 1104 SKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEP 1163
E V PP + F LTESDTVKRRPK +ERE
Sbjct: 970 PPRETPV--PP----------------------GLDFNLTESDTVKRRPKCRERE----- 1000
Query: 1164 PPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAK 1223
PL T + AS GP P P P E PP A P P P +
Sbjct: 1001 --PLQ-----TALLAFGVASATPGPAAPLPSPTPGESPP---ASSLPQPEPSSLPAQGVP 1050
Query: 1224 PPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPG--SPEVKRAHG-TPPPVSP----KPPP 1276
P++P P + PVP P PGPG S R +G T PP +P K P
Sbjct: 1051 TPLAPSPAMQPPVP-------------PCPGPGLESSAASRWNGETEPPAAPAALLKVPG 1097
Query: 1277 PPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPAL 1336
TAPKPV +VA +GP A P LG P PP P +
Sbjct: 1098 AGTAPKPV-SVACTQLAFSGPKLA------------------PRLGPRPVPPPRPESTGT 1138
Query: 1337 HVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDA 1396
PG A+Q+LE+TS+ LAAAL+A E+ I ++
Sbjct: 1139 --------------------------VGPG-QAQQRLEQTSSSLAAALRAAEKSIGTKEQ 1171
Query: 1397 QGPRDSAAEKSTGSILDDIGSMFDDLADQLDAMLE 1431
+G ST ILDDI +MFD LADQLDAML+
Sbjct: 1172 EG----TPSASTKHILDDISTMFDALADQLDAMLD 1202
>gi|217416350 cask-interacting protein 2 isoform b [Homo sapiens]
Length = 1120
Score = 763 bits (1970), Expect = 0.0
Identities = 562/1393 (40%), Positives = 697/1393 (50%), Gaps = 317/1393 (22%)
Query: 83 MRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPC 142
MRPLHYAAWQGR EP++L+L+A +AVN S +G IPLHLAAQ+GHY+VSEMLLQHQSNPC
Sbjct: 1 MRPLHYAAWQGRLEPVRLLLRASAAVNAASLDGQIPLHLAAQYGHYEVSEMLLQHQSNPC 60
Query: 143 MVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHI 202
+V+ + KTPLDLACEFGR+ V QLLL+S++C ALLE D DPN T+PLHLAAKNGH
Sbjct: 61 LVNKAKKTPLDLACEFGRLKVAQLLLNSHLCVALLEGEAKDPCDPNYTTPLHLAAKNGHR 120
Query: 203 DIIRLLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVH 262
++IR LL+AGI+INRQTK+GTALHEAAL GKTEVVRLLL+ G++ ++RNTY+QTALDIV+
Sbjct: 121 EVIRQLLRAGIEINRQTKTGTALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVN 180
Query: 263 QFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTSLNVKAGDIITVLEQHPDGRWKG 322
QFTTSQASREIKQLLREAS L+VRA KD+ N +D T+LNV+AGD+ITVLEQHPDGRWKG
Sbjct: 181 QFTTSQASREIKQLLREASGILKVRALKDFWNLHDPTALNVRAGDVITVLEQHPDGRWKG 240
Query: 323 CIHDNRTGNDRVGYFPSSLGEAIVKRAGSRAGTEPSLPQG-----SSSSGPSA--PPEEI 375
IH+++ G DR+GYFP + E + KR G A PS P S + P A PP +
Sbjct: 241 HIHESQRGTDRIGYFPPGIVEVVSKRVGIPAARLPSAPTPLRPGFSRTPQPPAEEPPHPL 300
Query: 376 WVLRKPFAGGDRSGSISGMAGGRGSGGHALHAGSEGVKLLATVLSQKSVSESGPG----D 431
+ P G S AG R S G GS ++ + S + + GPG +
Sbjct: 301 TYSQLPRVG----LSPDSPAGDRNSVGSEGSVGS--IRSAGSGQSSEGTNGHGPGLLIEN 354
Query: 432 SPAKPPEGSAGVARSQPPVAHAGQV---------YGEQ---PPKKLEPASEGKSSEAVSQ 479
+ P G V P + A + GEQ + E EGK ++A+
Sbjct: 355 AQPLPSAGEDQVLPGLHPPSLADNLSHRPLANCRSGEQIFTQDVRPEQLLEGKDAQAIHN 414
Query: 480 WLTAFQLQLYAPNFISAGYDLPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWLP 539
WL+ FQL+ Y +F+ AGYD+PTISRMTPEDLTAIGVTKPGHRKKIA+EI+ LSI +WLP
Sbjct: 415 WLSEFQLEGYTAHFLQAGYDVPTISRMTPEDLTAIGVTKPGHRKKIASEIAQLSIAEWLP 474
Query: 540 EHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAV 599
+ P +L WL +GL QY+K LV +GY+++ + D+TWE+LQEIG+ KLGHQKKLML V
Sbjct: 475 SYIPTDLLEWLCALGLPQYHKQLVSSGYDSMGLVADLTWEELQEIGVNKLGHQKKLMLGV 534
Query: 600 RKLAELQKA---EYAKYEGGPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSE 656
++LAEL++ A EGG K P+ + + +E+ P P++ TFQ SE
Sbjct: 535 KRLAELRRGLLQGEALSEGGRRLAKGPELMAIEGLENGEGPATA-----GPRLLTFQGSE 589
Query: 657 LSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPG 716
LS ELQAAM G GP P P A + S+G R+R SQE P G
Sbjct: 590 LSPELQAAMAGG---GPEP-------LPLPPARSPSQESIGARSRGSGHSQEQPAPQPSG 639
Query: 717 --PSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQVL--PPGTS 772
PS P R+ L EG PP K S P G P V P G+
Sbjct: 640 GDPSPPQERN----LPEGTE--RPP------------KLCSSLPGQGPPPYVFMYPQGSP 681
Query: 773 HFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGF 832
P P PG+P A GP PAT PP P P R
Sbjct: 682 SSPAPGPP----PGAPWAFSYLAGP-PAT----------PPD---------PPRPKRRSH 717
Query: 833 AYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSE 892
+ P P EG+ A GP +L YA
Sbjct: 718 SLSRPGPTEGDAEGEAEGPV---------------------------GSTLGSYATLTRR 750
Query: 893 PERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKR 952
P R L+ R+ P A + RSQSFA+R R+KGPPPPPPKR
Sbjct: 751 PGRSALV----------------RTSPSVTPTPA-RGTPRSQSFALRARRKGPPPPPPKR 793
Query: 953 SSSALASANLADEPVPDAE---PEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLE 1009
SS + + EP P E P++G G R R S+ AG
Sbjct: 794 LSSV---SGPSPEPPPLDESPGPKEGATGPRR--RTLSEPAG------------------ 830
Query: 1010 LSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGP 1069
P E P PA P AS +E GP G +R
Sbjct: 831 -------------PSEPPGPPAPAGP---------ASDTEEEEPGPEGTPPSR------- 861
Query: 1070 VTGLLATARRGPGESADPGPFVEDG--TGRQRPR--GPSKGEAGVEGPPLAKVEASATLK 1125
G S + PF E+G T +QRP+ GP E V PP
Sbjct: 862 ------------GSSGEGLPFAEEGNLTIKQRPKPAGPPPRETPV--PP----------- 896
Query: 1126 RRIRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQ 1185
+ F LTESDTVKRRPK +ERE PL T + AS
Sbjct: 897 -----------GLDFNLTESDTVKRRPKCRERE-------PLQ-----TALLAFGVASAT 933
Query: 1186 AGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTP 1245
GP P P P E PP A P P P + P++P P + PVP
Sbjct: 934 PGPAAPLPSPTPGESPP---ASSLPQPEPSSLPAQGVPTPLAPSPAMQPPVP-------- 982
Query: 1246 TSKKVPLPGPG--SPEVKRAHG-TPPPVSP----KPPPPPTAPKPVKAVAGLPSGSAGPS 1298
P PGPG S R +G T PP +P K P TAPKPV +VA +GP
Sbjct: 983 -----PCPGPGLESSAASRWNGETEPPAAPAALLKVPGAGTAPKPV-SVACTQLAFSGPK 1036
Query: 1299 PAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPA 1358
A P LG P PP P +
Sbjct: 1037 LA------------------PRLGPRPVPPPRPESTGT---------------------- 1056
Query: 1359 PPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGPRDSAAEKSTGSILDDIGSM 1418
PG A+Q+LE+TS+ LAAAL+A E+ I ++ +G ST ILDDI +M
Sbjct: 1057 ----VGPG-QAQQRLEQTSSSLAAALRAAEKSIGTKEQEG----TPSASTKHILDDISTM 1107
Query: 1419 FDDLADQLDAMLE 1431
FD LADQLDAML+
Sbjct: 1108 FDALADQLDAMLD 1120
Score = 42.7 bits (99), Expect = 0.002
Identities = 28/79 (35%), Positives = 42/79 (53%), Gaps = 1/79 (1%)
Query: 46 DPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAG 105
DP+ + LH AA NG+ E+I LL A ++ + K LH AA G+ E ++L+L+ G
Sbjct: 104 DPNYTTPLHLAAKNGHREVIRQLLRAGIEIN-RQTKTGTALHEAALYGKTEVVRLLLEGG 162
Query: 106 SAVNIPSDEGHIPLHLAAQ 124
VNI + L + Q
Sbjct: 163 VDVNIRNTYNQTALDIVNQ 181
Score = 37.7 bits (86), Expect = 0.080
Identities = 33/106 (31%), Positives = 51/106 (48%), Gaps = 11/106 (10%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPL----HYAAWQGRK 95
I +N Q G +ALH AAL G TE++ LLLE V+I++ L + Q +
Sbjct: 131 IEINRQTKTG-TALHEAALYGKTEVVRLLLEGGVDVNIRNTYNQTALDIVNQFTTSQASR 189
Query: 96 EPMKLVLKAGSAVNIPSDEG----HIPLHLAAQHGHYDVSEMLLQH 137
E +L+ +A + + + + H P L + G DV +L QH
Sbjct: 190 EIKQLLREASGILKVRALKDFWNLHDPTALNVRAG--DVITVLEQH 233
>gi|50511945 cajalin 2 isoform a [Homo sapiens]
Length = 1248
Score = 206 bits (524), Expect = 1e-52
Identities = 115/292 (39%), Positives = 189/292 (64%), Gaps = 22/292 (7%)
Query: 1 MGKEQELVQAVKAEDVGTAQRLLQRPRPG----------KAKLLGSTKKINVNFQDPDGF 50
MGK+QEL++A + +V ++LL + G + LL + NVN D G+
Sbjct: 1 MGKDQELLEAARTGNVALVEKLLSGRKGGILGGGSGPLPLSNLLSIWRGPNVNCTDSSGY 60
Query: 51 SALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAG---SA 107
+ALHHAALNG+ +++ LL+ +A+ ++ DNKG P+H AAW+G E +K+++ G S
Sbjct: 61 TALHHAALNGHKDIVLKLLQYEASTNVADNKGYFPIHLAAWKGDVEIVKILIHHGPSHSR 120
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
VN ++E LH AAQ+GH +V +LL+ ++P + ++ +TPLDLA +GR+ VV+++
Sbjct: 121 VNEQNNENETALHCAAQYGHSEVVAVLLEELTDPTIRNSKLETPLDLAALYGRLRVVKMI 180
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHE 227
+S++ R +PLHLAA+NGH ++++LL+AG+D++ QT+ G+ALHE
Sbjct: 181 ISAHPNLMSCNTRKH--------TPLHLAARNGHKAVVQVLLEAGMDVSCQTEKGSALHE 232
Query: 228 AALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLRE 279
AAL GK +VVR+LL++GI+A+++++ +T LDI+ + SQ S +I LL+E
Sbjct: 233 AALFGKVDVVRVLLETGIDANIKDSLGRTVLDILKEH-PSQKSLQIATLLQE 283
Score = 59.7 bits (143), Expect = 2e-08
Identities = 40/134 (29%), Positives = 67/134 (50%), Gaps = 12/134 (8%)
Query: 475 EAVSQWLTAFQLQLYAPNFISAGYDLPTI---SRMTPEDLTAIGVTKPGHRKKIAAEISG 531
+ V QWL + L Y + ++ G+D + M +DL IG+ GHR++I I
Sbjct: 813 QTVGQWLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQL 872
Query: 532 LSIPDWLP----EHKPANLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWED--LQEIG 585
L P P + P ++A WL I L Y K + NGY ++D + I WE + +
Sbjct: 873 L--PKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKI-WEVELINVLK 929
Query: 586 ITKLGHQKKLMLAV 599
I +GH+K+++ ++
Sbjct: 930 INLIGHRKRILASL 943
Score = 48.5 bits (114), Expect = 5e-05
Identities = 24/67 (35%), Positives = 40/67 (59%), Gaps = 2/67 (2%)
Query: 549 WLSMIGLAQYYKVLVDNGYENIDFITDITWE--DLQEIGITKLGHQKKLMLAVRKLAELQ 606
WL IGL QY L+ NG++N+ F+ E DL EIGI GH+++++ A++ L +++
Sbjct: 818 WLESIGLPQYENHLMANGFDNVQFMGSNVMEDQDLLEIGILNSGHRQRILQAIQLLPKMR 877
Query: 607 KAEYAKY 613
+ Y
Sbjct: 878 PIGHDGY 884
Score = 32.0 bits (71), Expect = 4.4
Identities = 22/89 (24%), Positives = 41/89 (46%), Gaps = 3/89 (3%)
Query: 462 PKKLEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGYDLPTISR--MTPEDLTAIGVTKP 519
PK +G +V++WL + +L Y F+ GY + + E + + +
Sbjct: 874 PKMRPIGHDGYHPTSVAEWLDSIELGDYTKAFLINGYTSMDLLKKIWEVELINVLKINLI 933
Query: 520 GHRKKIAAEISGLSIPDWLPEHKPANLAV 548
GHRK+I A + G + D P+ P ++ +
Sbjct: 934 GHRKRILASL-GDRLHDDPPQKPPRSITL 961
>gi|140161500 ankyrin repeat and sterile alpha motif domain
containing 1 [Homo sapiens]
Length = 1134
Score = 189 bits (480), Expect = 2e-47
Identities = 113/313 (36%), Positives = 183/313 (58%), Gaps = 43/313 (13%)
Query: 1 MGKEQELVQAVKAEDVGTAQRLLQRPRPGK------------------------------ 30
MGKEQEL++A + + ++LL R
Sbjct: 1 MGKEQELLEAARTGHLPAVEKLLSGKRLSSGFGGGGGGGSGGGGGGSGGGGGGLGSSSHP 60
Query: 31 -AKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYA 89
+ LL + NVN D G++ LHHAALNG+ +++ +LL A ++ D+KG PLH A
Sbjct: 61 LSSLLSMWRGPNVNCVDSTGYTPLHHAALNGHKDVVEVLLRNDALTNVADSKGCYPLHLA 120
Query: 90 AWQGRKEPMKLVLKAG---SAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDN 146
AW+G + ++L++ G + VN +++ LH AAQ+GH +V ++LL+ ++P M +N
Sbjct: 121 AWKGDAQIVRLLIHQGPSHTRVNEQNNDNETALHCAAQYGHTEVVKVLLEELTDPTMRNN 180
Query: 147 SGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIR 206
+TPLDLA +GR+ VV++LL+++ LL + + +PLHLAA+NGH +++
Sbjct: 181 KFETPLDLAALYGRLEVVKMLLNAH--PNLL------SCNTKKHTPLHLAARNGHKAVVQ 232
Query: 207 LLLQAGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTT 266
+LL AG+D N QT+ G+ALHEAAL GKT+VV++LL +G + ++++ + TALD V +
Sbjct: 233 VLLDAGMDSNYQTEMGSALHEAALFGKTDVVQILLAAGTDVNIKDNHGLTALDTVREL-P 291
Query: 267 SQASREIKQLLRE 279
SQ S++I L+ +
Sbjct: 292 SQKSQQIAALIED 304
Score = 70.9 bits (172), Expect = 9e-12
Identities = 137/645 (21%), Positives = 232/645 (35%), Gaps = 132/645 (20%)
Query: 53 LHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPS 112
LH AA NG+ ++ +LL+A + + G LH AA G+ + ++++L AG+ VNI
Sbjct: 219 LHLAARNGHKAVVQVLLDAGMDSNYQTEMGSA-LHEAALFGKTDVVQILLAAGTDVNIKD 277
Query: 113 DEGHIPLHLAAQ---HGHYDVSEMLLQHQSNPCMVDNSGKTP------------------ 151
+ G L + ++ ++ H + KTP
Sbjct: 278 NHGLTALDTVRELPSQKSQQIAALIEDHMTGKRSTKEVDKTPPPQPPLISSMDSISQKSQ 337
Query: 152 -----------LDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAA--- 197
+D G + L ++ C +L G ++D + T+ AA
Sbjct: 338 GDVEKAVTELIIDFDANAEEEGPYEALYNAISCHSLDSMASGRSSDQDSTNKEAEAAGVK 397
Query: 198 ---------------------KNGHIDIIRLLLQAGIDINRQTK-SGTAL-------HEA 228
+ HID L A ++ + + G+A +E
Sbjct: 398 PAGVRPRERPPPPAKPPPDEEEEDHIDKKYFPLTASEVLSMRPRIHGSAAREEDEHPYEL 457
Query: 229 ALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRA 288
L +T+ V +L+D H R++ S++ Q Q + LL +S +V
Sbjct: 458 LLTAETKKV-VLVDGKTKDHRRSSSSRSQDSAEGQ--DGQVPEQFSGLLHGSSPVCEV-- 512
Query: 289 TKDYCNNYDLTSLNVKAGDIITVLEQHPDGR-WKGCIHDNRTGNDRVGYFPSSLGEAIVK 347
D L AG + HPDG +G H + G +
Sbjct: 513 ------GQDPFQLLCTAG------QSHPDGSPQQGACHKASMQLEETGVHAPGASQPSAL 560
Query: 348 RAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAGGDRSGSISGMAGGRGSGGHALHA 407
R G LP +S S P E + P GG G SG A
Sbjct: 561 DQSKRVGYLTGLPTTNSRSHP----ETLTHTASPHPGGAEEGDRSG----------ARSR 606
Query: 408 GSEGVKLLATVLSQKSVSESGPGDSPAKPPEGSAGVARSQP-PVAHAGQVYGEQPP---- 462
K A + +S+S+S P E + +RS+ G+ E+ P
Sbjct: 607 APPTSKPKAELKLSRSLSKSDSDLLTCSPTEDATMGSRSESLSNCSIGKKRLEKSPSFAS 666
Query: 463 ------KKLEPASEGKS--------------SEAVSQWLTAFQLQLYAPNFISAGYD--- 499
K + EG ++V +WL + LQ Y + G+D
Sbjct: 667 EWDEIEKIMSSIGEGIDFSQERQKISGLRTLEQSVGEWLESIGLQQYESKLLLNGFDDVH 726
Query: 500 LPTISRMTPEDLTAIGVTKPGHRKKIAAEISGLSIPDWL--PEHKPANLAVWLSMIGLAQ 557
+ M +DL IG++ P HR+K+ L L + P ++ WL +GL
Sbjct: 727 FLGSNVMEEQDLRDIGISDPQHRRKLLQAARSLPKVKALGYDGNSPPSVPSWLDSLGLQD 786
Query: 558 YYKVLVDNGYENIDFITDITWEDLQEIGITK---LGHQKKLMLAV 599
Y + +GY +ID + ++ WE L+ + + K LGH+K+++ ++
Sbjct: 787 YVHSFLSSGYSSIDTVKNL-WE-LELVNVLKVQLLGHRKRIIASL 829
Score = 38.5 bits (88), Expect = 0.047
Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 4/84 (4%)
Query: 462 PKKLEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGY-DLPTISRMTPEDL-TAIGVTKP 519
PK +G S +V WL + LQ Y +F+S+GY + T+ + +L + V
Sbjct: 760 PKVKALGYDGNSPPSVPSWLDSLGLQDYVHSFLSSGYSSIDTVKNLWELELVNVLKVQLL 819
Query: 520 GHRKKIAAEISGLSIPDWLPEHKP 543
GHRK+I A ++ + P KP
Sbjct: 820 GHRKRIIASLADRPYEE--PPQKP 841
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 124 bits (311), Expect = 6e-28
Identities = 87/272 (31%), Positives = 136/272 (50%), Gaps = 14/272 (5%)
Query: 12 KAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEA 71
K ED TA + + L K +VN D +G + +H A +G ++ +LL
Sbjct: 500 KDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRR 559
Query: 72 QAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLK-AGSAVNIPSDEGHIPLHLAAQHGHYDV 130
V ++ PLHYAAWQG +KL+ K G +VN + +G PLHLAAQ GHY V
Sbjct: 560 GVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRV 619
Query: 131 SEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGT 190
+ +L+ S+ + +TPL +A E G +LLL +A +G
Sbjct: 620 ARILIDLCSDVNVCSLLAQTPLHVAAETGHTSTARLLLHRG--------AGKEAMTSDGY 671
Query: 191 SPLHLAAKNGHIDIIRLLLQAGIDI-NRQTKSGTALHEAALCGKTEVVRLLLDSGINAHV 249
+ LHLAA+NGH+ ++LL++ D+ R + TALH AA G +EVV L ++A V
Sbjct: 672 TALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVEEL----VSADV 727
Query: 250 RNTYSQTALDIVHQFTTSQASREIKQLLREAS 281
+ + + L +H + ++ ++ LLR +
Sbjct: 728 IDLFDEQGLSALHLAAQGRHAQTVETLLRHGA 759
Score = 120 bits (302), Expect = 7e-27
Identities = 79/242 (32%), Positives = 123/242 (50%), Gaps = 18/242 (7%)
Query: 38 KKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEP 97
+KI+VN +D D ++ALH AA NG+ LLLE A+V+ D +G P+H A G++
Sbjct: 493 RKISVNAKDEDQWTALHFAAQNGDESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENI 552
Query: 98 MKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDN-SGKTPLDLAC 156
++++L+ G V++ + +PLH AA GH + ++L + G+TPL LA
Sbjct: 553 VRILLRRGVDVSLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAA 612
Query: 157 EFGRVGVVQLLL----SSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAG 212
+ G V ++L+ N+C+ L + +PLH+AA+ GH RLLL G
Sbjct: 613 QRGHYRVARILIDLCSDVNVCSLLAQ------------TPLHVAAETGHTSTARLLLHRG 660
Query: 213 IDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASR 271
T G TALH AA G V+LL++ + R +QTAL + S+
Sbjct: 661 AGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTALHLAAAHGHSEVVE 720
Query: 272 EI 273
E+
Sbjct: 721 EL 722
Score = 105 bits (263), Expect = 2e-22
Identities = 80/266 (30%), Positives = 130/266 (48%), Gaps = 19/266 (7%)
Query: 15 DVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPD-------GFSALHHAALNGNTELISL 67
D+GT +Q+ + A + G T K+ Q D G S LH A G E
Sbjct: 399 DLGTTD--VQKKKLVDAIVSGDTSKLMKILQPQDVDLALDSGASLLHLAVEAGQEECAKW 456
Query: 68 LLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGH 127
LL A ++ + +G PLH A + + ++L+L +VN ++ LH AAQ+G
Sbjct: 457 LLLNNANPNLSNRRGSTPLHMAVERRVRGVVELLLARKISVNAKDEDQWTALHFAAQNGD 516
Query: 128 YDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDP 187
+ +LL+ ++ VD G+TP+ +AC+ G+ +V++LL + +L
Sbjct: 517 ESSTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRILLRRGVDVSL--------QGK 568
Query: 188 NGTSPLHLAAKNGHIDIIRLLL-QAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGI 245
+ PLH AA GH+ I++LL Q G+ +N QT G T LH AA G V R+L+D
Sbjct: 569 DAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCS 628
Query: 246 NAHVRNTYSQTALDIVHQFTTSQASR 271
+ +V + +QT L + + + +R
Sbjct: 629 DVNVCSLLAQTPLHVAAETGHTSTAR 654
Score = 89.7 bits (221), Expect = 2e-17
Identities = 58/188 (30%), Positives = 94/188 (50%), Gaps = 9/188 (4%)
Query: 32 KLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAW 91
KLL ++VN Q DG + LH AA G+ + +L++ + V++ PLH AA
Sbjct: 587 KLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNVCSLLAQTPLHVAAE 646
Query: 92 QGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTP 151
G +L+L G+ + +G+ LHLAA++GH ++L++ +++ +T
Sbjct: 647 TGHTSTARLLLHRGAGKEAMTSDGYTALHLAARNGHLATVKLLVEEKADVLARGPLNQTA 706
Query: 152 LDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQA 211
L LA G VV+ L+S+++ D D G S LHLAA+ H + LL+
Sbjct: 707 LHLAAAHGHSEVVEELVSADVI---------DLFDEQGLSALHLAAQGRHAQTVETLLRH 757
Query: 212 GIDINRQT 219
G IN Q+
Sbjct: 758 GAHINLQS 765
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 124 bits (310), Expect = 8e-28
Identities = 89/263 (33%), Positives = 130/263 (49%), Gaps = 26/263 (9%)
Query: 4 EQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTE 63
E L A +A A+ LLQ K VN + D + LH AA G+T
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQN-------------KAKVNAKAKDDQTPLHCAARIGHTN 517
Query: 64 LISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAA 123
++ LLLE A ++ G PLH AA +G E + +L+ ++ + +G PLH+AA
Sbjct: 518 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 577
Query: 124 QHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGD 183
++G V+E+LL+ ++P +G TPL +A + +V+LLL PR G
Sbjct: 578 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL----------PRGGS 627
Query: 184 ATDP--NGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240
P NG +PLH+AAK +++ R LLQ G N ++ G T LH AA G E+V LL
Sbjct: 628 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 687
Query: 241 LDSGINAHVRNTYSQTALDIVHQ 263
L N ++ N T L +V Q
Sbjct: 688 LSKQANGNLGNKSGLTPLHLVAQ 710
Score = 124 bits (310), Expect = 8e-28
Identities = 81/243 (33%), Positives = 126/243 (51%), Gaps = 9/243 (3%)
Query: 43 NFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102
N +G + LH A + N +++ LLL + G PLH AA Q + E + +L
Sbjct: 596 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 655
Query: 103 KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVG 162
+ G + N S +G PLHLAAQ GH ++ +LL Q+N + + SG TPL L + G V
Sbjct: 656 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 715
Query: 163 VVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG 222
V +L+ + DAT G +PLH+A+ G+I +++ LLQ D+N +TK G
Sbjct: 716 VADVLIKHGVMV--------DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 767
Query: 223 -TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREAS 281
+ LH+AA G T++V LLL +G + + ++ T L I + + +K + E S
Sbjct: 768 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 827
Query: 282 AAL 284
L
Sbjct: 828 FVL 830
Score = 116 bits (291), Expect = 1e-25
Identities = 82/285 (28%), Positives = 137/285 (48%), Gaps = 22/285 (7%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLL 69
A E++ AQ LL R +VNF +G + LH A+ GN ++ LLL
Sbjct: 246 AAHYENLNVAQLLLNRGA-------------SVNFTPQNGITPLHIASRRGNVIMVRLLL 292
Query: 70 EAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYD 129
+ A ++ K + PLH AA G +++L G+ + + G P+H+AAQ H D
Sbjct: 293 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 352
Query: 130 VSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNG 189
+LLQ+ + + TPL +A G V ++LL +P ++ NG
Sbjct: 353 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG-------AKP-NSRALNG 404
Query: 190 TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAH 248
+PLH+A K H+ ++ LLL+ G I+ T+SG T LH A+ G +V+ LL G + +
Sbjct: 405 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 464
Query: 249 VRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYC 293
V N +T L + + ++ ++ + Q + +A + T +C
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 509
Score = 113 bits (282), Expect = 1e-24
Identities = 70/214 (32%), Positives = 112/214 (52%), Gaps = 9/214 (4%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
+GF+ LH A + ++ LLL+ A++D G+ PLH A++ G +K +L+ G++
Sbjct: 403 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 462
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
N+ + + PLH+AA+ GH +V++ LLQ+++ +TPL A G +V+LL
Sbjct: 463 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 522
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
L +N P AT G +PLH+AA+ GH++ + LL+ TK G T LH
Sbjct: 523 LENN-------ANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 574
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
AA GK V LLL+ + + T L +
Sbjct: 575 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 608
Score = 106 bits (265), Expect = 1e-22
Identities = 71/241 (29%), Positives = 119/241 (49%), Gaps = 22/241 (9%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
+++N + +G + LH A+ G+ +++ LL + ++ KG LH AA G+ E ++
Sbjct: 69 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 128
Query: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFG 159
++ G+ VN S +G PL++AAQ H +V + LL++ +N + G TPL +A + G
Sbjct: 129 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 188
Query: 160 RVGVVQLLLS--------------------SNMCAALLEPRPG-DATDPNGTSPLHLAAK 198
VV L++ + A LL+ P D G +PLH+AA
Sbjct: 189 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 248
Query: 199 NGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTA 257
++++ +LLL G +N ++G T LH A+ G +VRLLLD G + T
Sbjct: 249 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 308
Query: 258 L 258
L
Sbjct: 309 L 309
Score = 87.4 bits (215), Expect = 9e-17
Identities = 51/168 (30%), Positives = 90/168 (53%), Gaps = 8/168 (4%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
+ N + G + LH AA G+ E+++LLL QA ++ + G+ PLH A +G +
Sbjct: 660 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 719
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
++K G V+ + G+ PLH+A+ +G+ + + LLQHQ++ G +PL A + G
Sbjct: 720 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 779
Query: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLL 208
+V LLL + P + + +GT+PL +A + G+I + +L
Sbjct: 780 TDIVTLLLKNG-------ASPNEVSS-DGTTPLAIAKRLGYISVTDVL 819
Score = 79.7 bits (195), Expect = 2e-14
Identities = 49/160 (30%), Positives = 81/160 (50%), Gaps = 2/160 (1%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGS--TKKINVNFQDPDGFSALHHAALNGNTELISL 67
+ AE V L + G A+++ +K+ N N + G + LH A G+ + +
Sbjct: 660 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 719
Query: 68 LLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGH 127
L++ VD G PLH A+ G + +K +L+ + VN + G+ PLH AAQ GH
Sbjct: 720 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 779
Query: 128 YDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
D+ +LL++ ++P V + G TPL +A G + V +L
Sbjct: 780 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 124 bits (310), Expect = 8e-28
Identities = 89/263 (33%), Positives = 130/263 (49%), Gaps = 26/263 (9%)
Query: 4 EQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTE 63
E L A +A A+ LLQ K VN + D + LH AA G+T
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQN-------------KAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 64 LISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAA 123
++ LLLE A ++ G PLH AA +G E + +L+ ++ + +G PLH+AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 124 QHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGD 183
++G V+E+LL+ ++P +G TPL +A + +V+LLL PR G
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL----------PRGGS 594
Query: 184 ATDP--NGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240
P NG +PLH+AAK +++ R LLQ G N ++ G T LH AA G E+V LL
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 241 LDSGINAHVRNTYSQTALDIVHQ 263
L N ++ N T L +V Q
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQ 677
Score = 124 bits (310), Expect = 8e-28
Identities = 81/243 (33%), Positives = 126/243 (51%), Gaps = 9/243 (3%)
Query: 43 NFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102
N +G + LH A + N +++ LLL + G PLH AA Q + E + +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 103 KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVG 162
+ G + N S +G PLHLAAQ GH ++ +LL Q+N + + SG TPL L + G V
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 163 VVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG 222
V +L+ + DAT G +PLH+A+ G+I +++ LLQ D+N +TK G
Sbjct: 683 VADVLIKHGVMV--------DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 223 -TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREAS 281
+ LH+AA G T++V LLL +G + + ++ T L I + + +K + E S
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Query: 282 AAL 284
L
Sbjct: 795 FVL 797
Score = 116 bits (291), Expect = 1e-25
Identities = 82/285 (28%), Positives = 137/285 (48%), Gaps = 22/285 (7%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLL 69
A E++ AQ LL R +VNF +G + LH A+ GN ++ LLL
Sbjct: 213 AAHYENLNVAQLLLNRGA-------------SVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 70 EAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYD 129
+ A ++ K + PLH AA G +++L G+ + + G P+H+AAQ H D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 130 VSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNG 189
+LLQ+ + + TPL +A G V ++LL +P ++ NG
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG-------AKP-NSRALNG 371
Query: 190 TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAH 248
+PLH+A K H+ ++ LLL+ G I+ T+SG T LH A+ G +V+ LL G + +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 249 VRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYC 293
V N +T L + + ++ ++ + Q + +A + T +C
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Score = 113 bits (282), Expect = 1e-24
Identities = 70/214 (32%), Positives = 112/214 (52%), Gaps = 9/214 (4%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
+GF+ LH A + ++ LLL+ A++D G+ PLH A++ G +K +L+ G++
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
N+ + + PLH+AA+ GH +V++ LLQ+++ +TPL A G +V+LL
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
L +N P AT G +PLH+AA+ GH++ + LL+ TK G T LH
Sbjct: 490 LENN-------ANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
AA GK V LLL+ + + T L +
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 106 bits (265), Expect = 1e-22
Identities = 71/241 (29%), Positives = 119/241 (49%), Gaps = 22/241 (9%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
+++N + +G + LH A+ G+ +++ LL + ++ KG LH AA G+ E ++
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFG 159
++ G+ VN S +G PL++AAQ H +V + LL++ +N + G TPL +A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 160 RVGVVQLLLS--------------------SNMCAALLEPRPG-DATDPNGTSPLHLAAK 198
VV L++ + A LL+ P D G +PLH+AA
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 199 NGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTA 257
++++ +LLL G +N ++G T LH A+ G +VRLLLD G + T
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 258 L 258
L
Sbjct: 276 L 276
Score = 87.4 bits (215), Expect = 9e-17
Identities = 51/168 (30%), Positives = 90/168 (53%), Gaps = 8/168 (4%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
+ N + G + LH AA G+ E+++LLL QA ++ + G+ PLH A +G +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
++K G V+ + G+ PLH+A+ +G+ + + LLQHQ++ G +PL A + G
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLL 208
+V LLL + P + + +GT+PL +A + G+I + +L
Sbjct: 747 TDIVTLLLKNG-------ASPNEVSS-DGTTPLAIAKRLGYISVTDVL 786
Score = 79.7 bits (195), Expect = 2e-14
Identities = 49/160 (30%), Positives = 81/160 (50%), Gaps = 2/160 (1%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGS--TKKINVNFQDPDGFSALHHAALNGNTELISL 67
+ AE V L + G A+++ +K+ N N + G + LH A G+ + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 68 LLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGH 127
L++ VD G PLH A+ G + +K +L+ + VN + G+ PLH AAQ GH
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 128 YDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
D+ +LL++ ++P V + G TPL +A G + V +L
Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 124 bits (310), Expect = 8e-28
Identities = 89/263 (33%), Positives = 130/263 (49%), Gaps = 26/263 (9%)
Query: 4 EQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTE 63
E L A +A A+ LLQ K VN + D + LH AA G+T
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQN-------------KAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 64 LISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAA 123
++ LLLE A ++ G PLH AA +G E + +L+ ++ + +G PLH+AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 124 QHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGD 183
++G V+E+LL+ ++P +G TPL +A + +V+LLL PR G
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL----------PRGGS 594
Query: 184 ATDP--NGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240
P NG +PLH+AAK +++ R LLQ G N ++ G T LH AA G E+V LL
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 241 LDSGINAHVRNTYSQTALDIVHQ 263
L N ++ N T L +V Q
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQ 677
Score = 124 bits (310), Expect = 8e-28
Identities = 81/243 (33%), Positives = 126/243 (51%), Gaps = 9/243 (3%)
Query: 43 NFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102
N +G + LH A + N +++ LLL + G PLH AA Q + E + +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 103 KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVG 162
+ G + N S +G PLHLAAQ GH ++ +LL Q+N + + SG TPL L + G V
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 163 VVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG 222
V +L+ + DAT G +PLH+A+ G+I +++ LLQ D+N +TK G
Sbjct: 683 VADVLIKHGVMV--------DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 223 -TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREAS 281
+ LH+AA G T++V LLL +G + + ++ T L I + + +K + E S
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Query: 282 AAL 284
L
Sbjct: 795 FVL 797
Score = 116 bits (291), Expect = 1e-25
Identities = 82/285 (28%), Positives = 137/285 (48%), Gaps = 22/285 (7%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLL 69
A E++ AQ LL R +VNF +G + LH A+ GN ++ LLL
Sbjct: 213 AAHYENLNVAQLLLNRGA-------------SVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 70 EAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYD 129
+ A ++ K + PLH AA G +++L G+ + + G P+H+AAQ H D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 130 VSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNG 189
+LLQ+ + + TPL +A G V ++LL +P ++ NG
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG-------AKP-NSRALNG 371
Query: 190 TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAH 248
+PLH+A K H+ ++ LLL+ G I+ T+SG T LH A+ G +V+ LL G + +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 249 VRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYC 293
V N +T L + + ++ ++ + Q + +A + T +C
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Score = 113 bits (282), Expect = 1e-24
Identities = 70/214 (32%), Positives = 112/214 (52%), Gaps = 9/214 (4%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
+GF+ LH A + ++ LLL+ A++D G+ PLH A++ G +K +L+ G++
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
N+ + + PLH+AA+ GH +V++ LLQ+++ +TPL A G +V+LL
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
L +N P AT G +PLH+AA+ GH++ + LL+ TK G T LH
Sbjct: 490 LENN-------ANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
AA GK V LLL+ + + T L +
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 106 bits (265), Expect = 1e-22
Identities = 71/241 (29%), Positives = 119/241 (49%), Gaps = 22/241 (9%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
+++N + +G + LH A+ G+ +++ LL + ++ KG LH AA G+ E ++
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFG 159
++ G+ VN S +G PL++AAQ H +V + LL++ +N + G TPL +A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 160 RVGVVQLLLS--------------------SNMCAALLEPRPG-DATDPNGTSPLHLAAK 198
VV L++ + A LL+ P D G +PLH+AA
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 199 NGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTA 257
++++ +LLL G +N ++G T LH A+ G +VRLLLD G + T
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 258 L 258
L
Sbjct: 276 L 276
Score = 87.4 bits (215), Expect = 9e-17
Identities = 51/168 (30%), Positives = 90/168 (53%), Gaps = 8/168 (4%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
+ N + G + LH AA G+ E+++LLL QA ++ + G+ PLH A +G +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
++K G V+ + G+ PLH+A+ +G+ + + LLQHQ++ G +PL A + G
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLL 208
+V LLL + P + + +GT+PL +A + G+I + +L
Sbjct: 747 TDIVTLLLKNG-------ASPNEVSS-DGTTPLAIAKRLGYISVTDVL 786
Score = 79.7 bits (195), Expect = 2e-14
Identities = 49/160 (30%), Positives = 81/160 (50%), Gaps = 2/160 (1%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGS--TKKINVNFQDPDGFSALHHAALNGNTELISL 67
+ AE V L + G A+++ +K+ N N + G + LH A G+ + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 68 LLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGH 127
L++ VD G PLH A+ G + +K +L+ + VN + G+ PLH AAQ GH
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 128 YDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
D+ +LL++ ++P V + G TPL +A G + V +L
Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 124 bits (310), Expect = 8e-28
Identities = 89/263 (33%), Positives = 130/263 (49%), Gaps = 26/263 (9%)
Query: 4 EQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTE 63
E L A +A A+ LLQ K VN + D + LH AA G+T
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQN-------------KAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 64 LISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAA 123
++ LLLE A ++ G PLH AA +G E + +L+ ++ + +G PLH+AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 124 QHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGD 183
++G V+E+LL+ ++P +G TPL +A + +V+LLL PR G
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL----------PRGGS 594
Query: 184 ATDP--NGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240
P NG +PLH+AAK +++ R LLQ G N ++ G T LH AA G E+V LL
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 241 LDSGINAHVRNTYSQTALDIVHQ 263
L N ++ N T L +V Q
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQ 677
Score = 124 bits (310), Expect = 8e-28
Identities = 81/243 (33%), Positives = 126/243 (51%), Gaps = 9/243 (3%)
Query: 43 NFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102
N +G + LH A + N +++ LLL + G PLH AA Q + E + +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 103 KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVG 162
+ G + N S +G PLHLAAQ GH ++ +LL Q+N + + SG TPL L + G V
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 163 VVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG 222
V +L+ + DAT G +PLH+A+ G+I +++ LLQ D+N +TK G
Sbjct: 683 VADVLIKHGVMV--------DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 223 -TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREAS 281
+ LH+AA G T++V LLL +G + + ++ T L I + + +K + E S
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Query: 282 AAL 284
L
Sbjct: 795 FVL 797
Score = 116 bits (291), Expect = 1e-25
Identities = 82/285 (28%), Positives = 137/285 (48%), Gaps = 22/285 (7%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLL 69
A E++ AQ LL R +VNF +G + LH A+ GN ++ LLL
Sbjct: 213 AAHYENLNVAQLLLNRGA-------------SVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 70 EAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYD 129
+ A ++ K + PLH AA G +++L G+ + + G P+H+AAQ H D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 130 VSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNG 189
+LLQ+ + + TPL +A G V ++LL +P ++ NG
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG-------AKP-NSRALNG 371
Query: 190 TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAH 248
+PLH+A K H+ ++ LLL+ G I+ T+SG T LH A+ G +V+ LL G + +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 249 VRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYC 293
V N +T L + + ++ ++ + Q + +A + T +C
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Score = 113 bits (282), Expect = 1e-24
Identities = 70/214 (32%), Positives = 112/214 (52%), Gaps = 9/214 (4%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
+GF+ LH A + ++ LLL+ A++D G+ PLH A++ G +K +L+ G++
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
N+ + + PLH+AA+ GH +V++ LLQ+++ +TPL A G +V+LL
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
L +N P AT G +PLH+AA+ GH++ + LL+ TK G T LH
Sbjct: 490 LENN-------ANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
AA GK V LLL+ + + T L +
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 106 bits (265), Expect = 1e-22
Identities = 71/241 (29%), Positives = 119/241 (49%), Gaps = 22/241 (9%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
+++N + +G + LH A+ G+ +++ LL + ++ KG LH AA G+ E ++
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFG 159
++ G+ VN S +G PL++AAQ H +V + LL++ +N + G TPL +A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 160 RVGVVQLLLS--------------------SNMCAALLEPRPG-DATDPNGTSPLHLAAK 198
VV L++ + A LL+ P D G +PLH+AA
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 199 NGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTA 257
++++ +LLL G +N ++G T LH A+ G +VRLLLD G + T
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 258 L 258
L
Sbjct: 276 L 276
Score = 87.4 bits (215), Expect = 9e-17
Identities = 51/168 (30%), Positives = 90/168 (53%), Gaps = 8/168 (4%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
+ N + G + LH AA G+ E+++LLL QA ++ + G+ PLH A +G +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
++K G V+ + G+ PLH+A+ +G+ + + LLQHQ++ G +PL A + G
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLL 208
+V LLL + P + + +GT+PL +A + G+I + +L
Sbjct: 747 TDIVTLLLKNG-------ASPNEVSS-DGTTPLAIAKRLGYISVTDVL 786
Score = 79.7 bits (195), Expect = 2e-14
Identities = 49/160 (30%), Positives = 81/160 (50%), Gaps = 2/160 (1%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGS--TKKINVNFQDPDGFSALHHAALNGNTELISL 67
+ AE V L + G A+++ +K+ N N + G + LH A G+ + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 68 LLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGH 127
L++ VD G PLH A+ G + +K +L+ + VN + G+ PLH AAQ GH
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 128 YDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
D+ +LL++ ++P V + G TPL +A G + V +L
Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 124 bits (310), Expect = 8e-28
Identities = 89/263 (33%), Positives = 130/263 (49%), Gaps = 26/263 (9%)
Query: 4 EQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTE 63
E L A +A A+ LLQ K VN + D + LH AA G+T
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQN-------------KAKVNAKAKDDQTPLHCAARIGHTN 484
Query: 64 LISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAA 123
++ LLLE A ++ G PLH AA +G E + +L+ ++ + +G PLH+AA
Sbjct: 485 MVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAA 544
Query: 124 QHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGD 183
++G V+E+LL+ ++P +G TPL +A + +V+LLL PR G
Sbjct: 545 KYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLL----------PRGGS 594
Query: 184 ATDP--NGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240
P NG +PLH+AAK +++ R LLQ G N ++ G T LH AA G E+V LL
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 241 LDSGINAHVRNTYSQTALDIVHQ 263
L N ++ N T L +V Q
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQ 677
Score = 124 bits (310), Expect = 8e-28
Identities = 81/243 (33%), Positives = 126/243 (51%), Gaps = 9/243 (3%)
Query: 43 NFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102
N +G + LH A + N +++ LLL + G PLH AA Q + E + +L
Sbjct: 563 NAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLL 622
Query: 103 KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVG 162
+ G + N S +G PLHLAAQ GH ++ +LL Q+N + + SG TPL L + G V
Sbjct: 623 QYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVP 682
Query: 163 VVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG 222
V +L+ + DAT G +PLH+A+ G+I +++ LLQ D+N +TK G
Sbjct: 683 VADVLIKHGVMV--------DATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLG 734
Query: 223 -TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREAS 281
+ LH+AA G T++V LLL +G + + ++ T L I + + +K + E S
Sbjct: 735 YSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLKVVTDETS 794
Query: 282 AAL 284
L
Sbjct: 795 FVL 797
Score = 116 bits (291), Expect = 1e-25
Identities = 82/285 (28%), Positives = 137/285 (48%), Gaps = 22/285 (7%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLL 69
A E++ AQ LL R +VNF +G + LH A+ GN ++ LLL
Sbjct: 213 AAHYENLNVAQLLLNRGA-------------SVNFTPQNGITPLHIASRRGNVIMVRLLL 259
Query: 70 EAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYD 129
+ A ++ K + PLH AA G +++L G+ + + G P+H+AAQ H D
Sbjct: 260 DRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLD 319
Query: 130 VSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNG 189
+LLQ+ + + TPL +A G V ++LL +P ++ NG
Sbjct: 320 CVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG-------AKP-NSRALNG 371
Query: 190 TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAH 248
+PLH+A K H+ ++ LLL+ G I+ T+SG T LH A+ G +V+ LL G + +
Sbjct: 372 FTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPN 431
Query: 249 VRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYC 293
V N +T L + + ++ ++ + Q + +A + T +C
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHC 476
Score = 113 bits (282), Expect = 1e-24
Identities = 70/214 (32%), Positives = 112/214 (52%), Gaps = 9/214 (4%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
+GF+ LH A + ++ LLL+ A++D G+ PLH A++ G +K +L+ G++
Sbjct: 370 NGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGAS 429
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
N+ + + PLH+AA+ GH +V++ LLQ+++ +TPL A G +V+LL
Sbjct: 430 PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLL 489
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
L +N P AT G +PLH+AA+ GH++ + LL+ TK G T LH
Sbjct: 490 LENN-------ANPNLATTA-GHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLH 541
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
AA GK V LLL+ + + T L +
Sbjct: 542 VAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHV 575
Score = 106 bits (265), Expect = 1e-22
Identities = 71/241 (29%), Positives = 119/241 (49%), Gaps = 22/241 (9%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
+++N + +G + LH A+ G+ +++ LL + ++ KG LH AA G+ E ++
Sbjct: 36 VDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVR 95
Query: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFG 159
++ G+ VN S +G PL++AAQ H +V + LL++ +N + G TPL +A + G
Sbjct: 96 ELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQG 155
Query: 160 RVGVVQLLLS--------------------SNMCAALLEPRPG-DATDPNGTSPLHLAAK 198
VV L++ + A LL+ P D G +PLH+AA
Sbjct: 156 HENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAH 215
Query: 199 NGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTA 257
++++ +LLL G +N ++G T LH A+ G +VRLLLD G + T
Sbjct: 216 YENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTP 275
Query: 258 L 258
L
Sbjct: 276 L 276
Score = 87.4 bits (215), Expect = 9e-17
Identities = 51/168 (30%), Positives = 90/168 (53%), Gaps = 8/168 (4%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
+ N + G + LH AA G+ E+++LLL QA ++ + G+ PLH A +G +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
++K G V+ + G+ PLH+A+ +G+ + + LLQHQ++ G +PL A + G
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLL 208
+V LLL + P + + +GT+PL +A + G+I + +L
Sbjct: 747 TDIVTLLLKNG-------ASPNEVSS-DGTTPLAIAKRLGYISVTDVL 786
Score = 79.7 bits (195), Expect = 2e-14
Identities = 49/160 (30%), Positives = 81/160 (50%), Gaps = 2/160 (1%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGS--TKKINVNFQDPDGFSALHHAALNGNTELISL 67
+ AE V L + G A+++ +K+ N N + G + LH A G+ + +
Sbjct: 627 SANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADV 686
Query: 68 LLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGH 127
L++ VD G PLH A+ G + +K +L+ + VN + G+ PLH AAQ GH
Sbjct: 687 LIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGH 746
Query: 128 YDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
D+ +LL++ ++P V + G TPL +A G + V +L
Sbjct: 747 TDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
>gi|163965366 nascent polypeptide-associated complex alpha subunit
isoform a [Homo sapiens]
Length = 2078
Score = 121 bits (303), Expect = 5e-27
Identities = 190/775 (24%), Positives = 247/775 (31%), Gaps = 119/775 (15%)
Query: 633 SPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPA-EVGPTTEKPSSHLPPTPRATTR 691
+P PP TP SPK S A T P+ + GP T P PTP A T
Sbjct: 939 APTPPAATPP---SPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKG--APTPPAAT- 992
Query: 692 QDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSI 751
S GG A PP + P + TPP P G
Sbjct: 993 PPSPKGGPATPSPKGAPT----PPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPA 1048
Query: 752 KRASVPPVPGKPRQVLP-----PGTSHFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKP 806
P P LP P T TP P SP+ GGP P+P A
Sbjct: 1049 ATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPK--GGPATPSPKGAP--- 1103
Query: 807 TPQLLPPTERPMSPRSLPQSPTHRGF-------------AYVLPQPVEGEVGPAAPGPAP 853
+PP P SP+ +P H+G P P PAA P+P
Sbjct: 1104 ----MPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSP 1159
Query: 854 P-----PVPTAVPTL--CLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAG- 905
P P PT PP P + A S + L P+ G
Sbjct: 1160 KGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSP--KGGLATPSPKGA 1217
Query: 906 ---PYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANL 962
P AT G + +P GA + A P KG P PP + + +A
Sbjct: 1218 PTTPAATPPSPKG-GLATPSPKGAP-----TTPAATPPSPKGGPATPPPKGAPTPPAATP 1271
Query: 963 ADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARR 1022
A P A S G + G+ AA + G
Sbjct: 1272 PSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAA----TPPSPKGSPGTP 1327
Query: 1023 PPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPG 1082
PP+G PTP +P + L + GP + GP + +G
Sbjct: 1328 PPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGP-----TTPSSKEGPTPPAATPSHKGGP 1382
Query: 1083 ESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFIL 1142
P P + G P+G A + PL+ +A AT R A + ++
Sbjct: 1383 AMTPPSP--KRGPAIPSPKGDPTSPAVI---PLSPKKAPATPVTREGAATPSKGDLTPPA 1437
Query: 1143 TESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPP--PPPPAEP 1200
++K+ P + GP P G P LP PP P EP
Sbjct: 1438 VTPVSLKKAPATSAPKGGPATP-------------------SSKGDPTLPAVTPPSPKEP 1478
Query: 1201 P-PTDLA------HLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLP 1253
P P +A P P P G PA P SPK V TP+S++ P+
Sbjct: 1479 PAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEV----------PATPSSRRDPIA 1528
Query: 1254 GPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAK 1313
+ K+ T P PP T P P K A A +P+ A PPA
Sbjct: 1529 PTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPS 1588
Query: 1314 P-PGTP-------PSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPP 1360
G P P SP+ +P PA+ P+ P A A P +PP
Sbjct: 1589 TYKGAPSPKELLIPPAVTSPSPKEAPTPPAVTPPS--PEKGPATPAPKGTPTSPP 1641
Score = 119 bits (299), Expect = 2e-26
Identities = 223/874 (25%), Positives = 284/874 (32%), Gaps = 159/874 (18%)
Query: 617 PLRRKAPQSLEVMAIESP-PPPEPTPADCQS------PKMTTFQDSE-LSDELQAAMTGP 668
P+ K P + + P PP P P D ++ K T +D + + L+ A P
Sbjct: 487 PVAPKEPSTQVATTLRIPVSPPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAPFSP 546
Query: 669 AEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYL 728
A+ G TT+K + LP A S + SSS E+ P SP + +
Sbjct: 547 AQAGLTTKKDPTVLPLVQAAPKNSPSF-----QSTSSSPEI-------PLSPEATLAKKS 594
Query: 729 LDEGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSP 788
L E P P P + G + S V P T T P
Sbjct: 595 LGE-PLPIGKPASSMTSPLGVN----SSASVIKTDSYAGPDSAGPLLKSSLITPTVAAFP 649
Query: 789 QALGGPHGPAPATAKVKPT------PQL-----LPPTERPMSP---RSLPQSPTHRGFAY 834
P G AP TAK T P L L P P+ +LP PT
Sbjct: 650 LESADPAGVAPTTAKGTSTYTTTASPFLEGTVSLAPKNHPVKEGTLTTLPLVPTASENCP 709
Query: 835 VLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPK----KRAHSLNRYAASD 890
V P P + P A P +P +VP+ LPP A PG K +L A+S
Sbjct: 710 VAPSP-QNTCAPLATLVLAPEIPKSVPSPSLPP-AGTPPGTKKVDGISHTSALAPVASSP 767
Query: 891 SEPERDELLVPAAAGPYAT--------------VQRRVGRSHSVRAPAGADKNVNRSQSF 936
E ++ A A T V + R + + AG D + S
Sbjct: 768 KECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGNLSS- 826
Query: 937 AVRPRKKG---------------------PPPPPPKRSSSALASANLADEPV---PDAEP 972
V P + P PP PK + + A L+ + V P P
Sbjct: 827 PVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETP 886
Query: 973 EDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPR- 1031
+ V + + A S+ S + ++ G A P+G PTP
Sbjct: 887 TPSV--VNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPA 944
Query: 1032 ---------PASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPG 1082
PA+P P T A+ GP + G T AT G
Sbjct: 945 ATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATP------SPKGAPTPPAATPPSPKG 998
Query: 1083 ESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFIL 1142
A P P P P A P A +AT +
Sbjct: 999 GPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPT 1058
Query: 1143 TESDTV---KRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPP---- 1195
T + T+ K P + P PP G G P P PP P
Sbjct: 1059 TPAATLPSPKGGPATPSLKGAPTPPAATPPSPKG-GPATPSPKGAPMPPAATPPSPKGGL 1117
Query: 1196 --PPAEPPPTDLAHLPP-------LPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPT 1246
PP + PT A PP PPP+G PA P SPK L P PK G+PT
Sbjct: 1118 ATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPK--GAPTTP 1175
Query: 1247 SKKVPLP--GPGSPEVKRAHGTPPPVSPKP------PPPPTAPKPVKAVAGLPSGSAG-- 1296
+ P P G +P K A TP P P P P AP A P G
Sbjct: 1176 AATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATP 1235
Query: 1297 -------------PSPAPSPARQPPAALAKPPG-TPPSLGASPAKPPSPGAP--ALHVP- 1339
PSP PA PP PP TPPSL A PP GAP A+ P
Sbjct: 1236 SPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPP 1295
Query: 1340 -------AKPPRAAAAAAAAAAAPPAPPEGASPG 1366
PP+ A AA PP+P SPG
Sbjct: 1296 SPKGGPATSPPKGAP--TPPAATPPSPK--GSPG 1325
Score = 117 bits (293), Expect = 8e-26
Identities = 193/733 (26%), Positives = 239/733 (32%), Gaps = 141/733 (19%)
Query: 678 PSSHLPP--TPRATTRQD--SSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGP 733
PS LPP TP T + D S A SS +E + ++ S+ L + P
Sbjct: 735 PSPSLPPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSP 794
Query: 734 AP---GTPPREARPGRHGHSIKRASVPPVP-GKPRQVLPPGTSHFTPPQTPTKTRPGSPQ 789
+P P+ RP K ++ P P G + P + F P + + GS
Sbjct: 795 SPLGVSVSPQTKRPPTK----KGSAGPDTPIGNLSSPVSPVEASFLPENS--LSFQGSKD 848
Query: 790 ALGGPHGPAPATAKVKPTPQLLPPTERPMSPR--SLPQSPTHRGFAYVLPQPVEGEVGPA 847
+ H P P + K PTP + P +SP+ +LP T LP P EG PA
Sbjct: 849 SPATTHSPTPPSPKGAPTPSAVTP----LSPKGVTLPPKETPTPSVVNLPFPKEG---PA 901
Query: 848 APGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPY 907
P AP P T P +A A P PK + P P AA P
Sbjct: 902 TP--APKQAPALSMTSSSPKKARATPA-PK----------GIPASPSPKGAPTPPAATP- 947
Query: 908 ATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPV 967
P+ S +A P PP P + A S A P
Sbjct: 948 ---------------PSPKGGPATPSPKWAPTPPAATPPSP---KGGPATPSPKGAPTP- 988
Query: 968 PDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGH 1027
P A P G + + +V S G AA P+G
Sbjct: 989 PAATPPSPKGGPATPSPKGAPTPPAVTPPSPK----------------GSPAATPFPKGA 1032
Query: 1028 PTP---RPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRG-PGE 1083
TP P SP+ AT L P G TL P G + +G P
Sbjct: 1033 STPPAATPPSPKGSPAATPL----------PKGAPTTPAATLPSPKGGPATPSLKGAPTP 1082
Query: 1084 SADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILT 1143
A P + G P+G A P + K T
Sbjct: 1083 PAATPPSPKGGPATPSPKGAPMPPAATPPSPKGGLATPPH---------------KGAPT 1127
Query: 1144 ESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPT 1203
PK G PPP T P A PP P PA PP+
Sbjct: 1128 TPAATPPSPKG-----GLATPPPKGAPTTPAATPPS-PKGGLATPPPKGAPTTPAATPPS 1181
Query: 1204 DLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLP--GPGSPEVK 1261
L P P+G PA P SPK L P PK G+PT + P P G +P K
Sbjct: 1182 PKGGLAT-PSPKGAPTTPAATPPSPKGGLATPSPK--GAPTTPAATPPSPKGGLATPSPK 1238
Query: 1262 RAHGTPPPVSPKP------PPPPTAPKPVKAV---------------AGLPSGSAGPSPA 1300
A TP P P PPP AP P A A P+ PSP
Sbjct: 1239 GAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPK 1298
Query: 1301 PSPARQPPAALAKPP-GTPPSLGASPAKPPSPGAPALHVPAKP-----PRAAAAAAAAAA 1354
PA PP PP TPPS SP PP GAP P P A ++
Sbjct: 1299 GGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKG 1358
Query: 1355 AP--PAPPEGASP 1365
P P+ EG +P
Sbjct: 1359 GPTTPSSKEGPTP 1371
Score = 111 bits (278), Expect = 4e-24
Identities = 211/896 (23%), Positives = 288/896 (32%), Gaps = 150/896 (16%)
Query: 633 SPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQ 692
+P PP TP SPK S + A T P+ G P P TP AT
Sbjct: 1079 APTPPAATPP---SPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATP-- 1133
Query: 693 DSSLGGRARHMSSSQELLGDG-PPGPSSPMSRSQEYLLDEGPAPGTPPRE----ARPGRH 747
S GG A PP P ++ PA TPP A P
Sbjct: 1134 PSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPA-ATPPSPKGGLATPSPK 1192
Query: 748 GHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPG--SPQALGGPHGPAPATAKVK 805
G A+ PP P P + TP TP + G +P G P PA K
Sbjct: 1193 GAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPK 1252
Query: 806 PTPQLLPPTERPMSPRSLPQS-------PTHRGF---AYVLPQPVEGEVGPAAPGPAPPP 855
P PP P P + P S P H+G A V P +G GPA P P
Sbjct: 1253 GGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKG--GPATSPPKGAP 1310
Query: 856 VPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELL---VPAAAGPYATVQR 912
P A PP PG P + + A + P+ L P++ G T
Sbjct: 1311 TPPAAT----PPSPKGSPGTPPPKG-APTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSS 1365
Query: 913 RVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEP 972
+ G + P A + + K+GP P PK ++ A L+ + P A P
Sbjct: 1366 KEGPT-----PPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAP-ATP 1419
Query: 973 EDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRP 1032
+ A+ G + + V A + GG + + P P
Sbjct: 1420 V-------TREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTP 1472
Query: 1033 ASPE----PGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPGESADPG 1088
SP+ P +VAT + K P G TL + P DP
Sbjct: 1473 PSPKEPPAPKQVATSSSPKKAPATPAPMGAP-----TLPAVIPSSPKEVPATPSSRRDPI 1527
Query: 1089 PFVEDGTGRQRPRGPSKGEA----GVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTE 1144
++ P + EA + P K A T K +++ + +T
Sbjct: 1528 APTATLLSKKTPATLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTP 1587
Query: 1145 SDTVKRRPKAKEREAGP--------EPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPP 1196
S T K P KE P E P P +V P S + GP P
Sbjct: 1588 S-TYKGAPSPKELLIPPAVTSPSPKEAPTPPAV----------TPPSPEKGPATPAPKGT 1636
Query: 1197 PAEPP--PTDLAHLPPLPP----------PEGEARKPAKP-PVSPKPVLTQPVPKLQGSP 1243
P PP P+ L P P P+ PAK P + K VL P P+
Sbjct: 1637 PTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVAPAPESTPII 1696
Query: 1244 TPTSKKVPLPGPGSPEVKRAHGTPPPVSPKP----------------------------- 1274
T ++K P+ K++ T PP+ P P
Sbjct: 1697 TAPTRK-------GPQTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTA 1749
Query: 1275 --------PPPPTAPKPVKAVAGLPSG----------SAGPSPAPSPARQPPAALAKPPG 1316
P P AP KA L + SA S APSP P A + P
Sbjct: 1750 KGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSPVPT 1809
Query: 1317 TPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKL-EE 1375
PP P SPG L P+KP A PP P G P S +
Sbjct: 1810 LPPK---QQFLPSSPGL-VLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTP 1865
Query: 1376 TSACLAAALQAVEEKIRQEDAQGPRDSAAEKSTGSILDDIGSMFDDLADQLDAMLE 1431
SA + + ++ + + + +S +++S + + + QL A E
Sbjct: 1866 KSAGIPVPTPSAKQPVTKNNKGSGTESDSDESVPELEEQDSTQATTQQAQLAAAAE 1921
Score = 111 bits (277), Expect = 6e-24
Identities = 190/818 (23%), Positives = 259/818 (31%), Gaps = 118/818 (14%)
Query: 614 EGGPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGP 673
+GGP +P+ +PP P+ +PA PK + A T P+ G
Sbjct: 997 KGGPAT-PSPKGAPTPPAVTPPSPKGSPAATPFPKGAS---------TPPAATPPSPKGS 1046
Query: 674 TTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPP----GPSSPMSRSQEYLL 729
P PT A T G + + PP GP++P +
Sbjct: 1047 PAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPM-- 1104
Query: 730 DEGPAPGTPPRE----ARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRP 785
P TPP A P G A+ PP P PP + TP TP +
Sbjct: 1105 ---PPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKG 1161
Query: 786 G--SPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGE 843
G +P G P PA K P P +P + P SP P P
Sbjct: 1162 GLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKG---GLATPSPKGAP 1218
Query: 844 VGPAAPGPAPP-----PVPTAVPTL--CLPPEADAEPGRPKKRAHSLNRYAASDSEPERD 896
PAA P+P P P PT PP P P + P
Sbjct: 1219 TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKG-----------APTPP 1267
Query: 897 ELLVPAAAGPYATVQRRVGRSHSV-------RAPAGADKNVNRSQSFAVRPRKKGPPPPP 949
P+ G AT + + +V PA + + A P KG P P
Sbjct: 1268 AATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTP 1327
Query: 950 PKRSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLE 1009
P + + P P A G G T S+ + A
Sbjct: 1328 PPKGA-----------PTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATP 1376
Query: 1010 LSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEA--IGPGGEVVNRRRTLS 1067
S GG P G P P +P A + S K A + G + L+
Sbjct: 1377 -SHKGGPAMTPPSPKRGPAIPSPKG-DPTSPAVIPLSPKKAPATPVTREGAATPSKGDLT 1434
Query: 1068 GPVTGLLATARRGPGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRR 1127
P ++ + + GP G P P+ + PP K A+++ ++
Sbjct: 1435 PPAVTPVSLKKAPATSAPKGGPATPSSKGD--PTLPAVTPPSPKEPPAPKQVATSSSPKK 1492
Query: 1128 IRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRR-----PA 1182
A + K P P P + T+ + PA
Sbjct: 1493 APATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPA 1552
Query: 1183 SEQAGPPELPPPPPPAEPPPTDL---AHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKL 1239
P + P P P E P T A PP P P+ + P +T P PK
Sbjct: 1553 MTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIPPAVTSPSPKE 1612
Query: 1240 QGSPTPTSKKVPLPGPGSPEVKRAHGTP--PPVSPKP-PPPPTAPKPV---------KAV 1287
+P + P GP +P K GTP PPV+P PT+P V +A
Sbjct: 1613 APTPPAVTPPSPEKGPATPAPK---GTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQAS 1669
Query: 1288 AGLPSGSAGPSP------APSPARQP--PAALAKPPGTPPSLGASPAKPPSPG------- 1332
GLP+ GP+ AP+P P A K P T S SP P P
Sbjct: 1670 KGLPA-KKGPTALKEVLVAPAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNGSKG 1728
Query: 1333 -----APALHVPAKPPRAAAA----AAAAAAAPPAPPE 1361
APA +P + + A A+ + P APPE
Sbjct: 1729 PLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPE 1766
Score = 46.6 bits (109), Expect = 2e-04
Identities = 139/610 (22%), Positives = 202/610 (33%), Gaps = 127/610 (20%)
Query: 759 VPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQ-----ALG--GPHGPAPATAKVKPTPQLL 811
+PG+ + +P PQ T P S ALG GP P P + P PQ
Sbjct: 1 MPGEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCS----PAPQQC 56
Query: 812 P-PTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEAD 870
P SP P + PQ G A P P PT +P L PP +
Sbjct: 57 PLSAANQASPFPSPSTIASTPLEVPFPQ---SSSGTALPLGTAPEAPTFLPNLIGPPISP 113
Query: 871 AEPGRPKKRAHSLNRYAASDSEPERDELL--VPAAAGPYATVQRRVGRSHSVRAPAGADK 928
A A + + P L P+++ P A V A A
Sbjct: 114 A---------------ALALASPMIAPTLKGTPSSSAPLALV-------------ALAPH 145
Query: 929 NVNRSQSFAVRPRKKGPP---PPPPKRSSSALASANLADEPVPDAEPEDGLLGVRAQCRR 985
+V +S +F PP PP + + S P+ +EP+ L V ++
Sbjct: 146 SVQKSSAF--------PPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEV-- 195
Query: 986 ASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLA 1045
+ G+ S + ++SI G + P+ PT A P T ++
Sbjct: 196 VPNPKGTPSPPCIVSTVPYHCVTPMASIQSGVASL---PQTTPTTTLAIASPQVKDTTIS 252
Query: 1046 SVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPGESADPGPFVEDGTGRQRPRGPSK 1105
SV PG +L GPV+ A + S P V T Q+ GP+
Sbjct: 253 SVLISPQ-NPGS------LSLKGPVSPPAALSL-----STQSLPVV---TSSQKTAGPNT 297
Query: 1106 GEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPP 1165
PP + + L Q+ +V+ + + P K
Sbjct: 298 -------PPDFPISLGSHLAP---LHQSSFGSVQLLGQTGPSALSDPTVKT--------- 338
Query: 1166 PLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPP 1225
+SV H+ TG AS + +PP P E P +A P + P K P
Sbjct: 339 -ISVDHSSTG------ASYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVD------KGP 385
Query: 1226 VSPKPVLTQPVPKLQG----SPTPTSKKVPLPGPGS----PEVKR----AHGTPPPVSPK 1273
+ + P L S +PT+ + P + P V + + GT P V
Sbjct: 386 STISSITCSPSGSLNVATSFSLSPTTSLILKSSPNATYHYPLVAQMPVSSVGTTPLVVTN 445
Query: 1274 PPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGA 1333
P AP VA S P + PAAL P +P +P + A
Sbjct: 446 PCTIAAAPTTTFEVATCVSPPMSSGPISNIEPTSPAALVMAP-------VAPKEPSTQVA 498
Query: 1334 PALHVPAKPP 1343
L +P PP
Sbjct: 499 TTLRIPVSPP 508
Score = 46.6 bits (109), Expect = 2e-04
Identities = 175/838 (20%), Positives = 267/838 (31%), Gaps = 148/838 (17%)
Query: 634 PPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQD 693
PPP P P C P Q S A T P EV P P++++
Sbjct: 46 PPPCSPAPQQC--PLSAANQASPFPSPSTIAST-PLEV------------PFPQSSSGTA 90
Query: 694 SSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSIKR 753
LG + L+G P SP + + + GTP A +
Sbjct: 91 LPLGTAPEAPTFLPNLIGP----PISPAALALASPMIAPTLKGTPSSSA-------PLAL 139
Query: 754 ASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPP 813
++ P + PP T P + GS L P P+ + P + P
Sbjct: 140 VALAPHSVQKSSAFPPNL--LTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVP 197
Query: 814 TER------------------PMSP-----RSLPQSPTHRGFAYVLPQPVEGEVG----- 845
+ PM+ SLPQ+ A PQ + +
Sbjct: 198 NPKGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIASPQVKDTTISSVLIS 257
Query: 846 PAAPG------PAPPPVPTAVPTLCLP----PEADAEPGRPKKRAHSLNRYAASDSEPER 895
P PG P PP ++ T LP + A P P SL + A +
Sbjct: 258 PQNPGSLSLKGPVSPPAALSLSTQSLPVVTSSQKTAGPNTPPDFPISLGSHLAPLHQSSF 317
Query: 896 DELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSS 955
+ + GP A + P +V+ S + A P ++ PP P R+
Sbjct: 318 GSVQLLGQTGPSA-----------LSDPTVKTISVDHSSTGASYPSQRSVIPPLPSRNE- 365
Query: 956 ALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGG 1015
+ A +A PV + G + + S GS++ ++ S+ +++ SS
Sbjct: 366 -VVPATVAAFPVVAPSVDKGPSTISSITCSPS---GSLNVATSFSLSPTTSLILKSS--- 418
Query: 1016 GGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLA 1075
P + P A V T V + I + P T
Sbjct: 419 -------PNATYHYPLVAQMPVSSVGTTPLVVTNPCTIA------------AAPTTTFEV 459
Query: 1076 TARRGPGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQ 1135
P S+ P +E P P+ P + + TL+ +
Sbjct: 460 ATCVSPPMSSGPISNIE-------PTSPAALVMAPVAPKEPSTQVATTLRIPVSPPLPDP 512
Query: 1136 ENVKFILTESDTVKRRPKAKEREAGPEP--PPPLSVYHNGTGTVRRRPAS---EQAGPPE 1190
E++K + S + + P K+ + P P S G T ++ P QA P
Sbjct: 513 EDLKNL--PSSVLVKFPTQKDLQTVPASLEGAPFSPAQAGL-TTKKDPTVLPLVQAAPKN 569
Query: 1191 LPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVS-PKPVLTQPVPKLQGSPTPTSKK 1249
P + P PL P A+K P+ KP + P S K
Sbjct: 570 SPSFQSTSSSPEI------PLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKT 623
Query: 1250 VPLPGPGS--PEVKRAHGTPPPVS-PKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQ 1306
GP S P +K + TP + P P P A G++ + SP +
Sbjct: 624 DSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTA-----KGTSTYTTTASPFLE 678
Query: 1307 PPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAA----------AAAAP 1356
+LA P P G P P A A P+ A A + +P
Sbjct: 679 GTVSLA-PKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSP 737
Query: 1357 PAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGPRDSAAEKSTGSILDD 1414
PP G PG + TSA A + + ++ ED+ G +A+ K T + L D
Sbjct: 738 SLPPAGTPPGTKKVDGISHTSA--LAPVASSPKECPTEDS-GASATASSKGTLTYLAD 792
Score = 43.5 bits (101), Expect = 0.001
Identities = 44/141 (31%), Positives = 55/141 (39%), Gaps = 15/141 (10%)
Query: 1233 TQPVPKL-QGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLP 1291
T+ VP Q P P ++ LP + V A G P P P P P P+ A
Sbjct: 6 TETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSA----- 60
Query: 1292 SGSAGPSPAPSPARQPPAALAKP---PGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAA 1348
+ A P P+PS P + P GT LG +P P P L P P A
Sbjct: 61 ANQASPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTF--LPNLIGPPISP----A 114
Query: 1349 AAAAAAAPPAPPEGASPGDSA 1369
A A A+ AP +P SA
Sbjct: 115 ALALASPMIAPTLKGTPSSSA 135
Score = 42.7 bits (99), Expect = 0.002
Identities = 47/188 (25%), Positives = 67/188 (35%), Gaps = 17/188 (9%)
Query: 1182 ASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQG 1241
A+E E P P AE ++ + G+ PP SP P Q
Sbjct: 5 ATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQQCPLSAANQA 64
Query: 1242 SPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPV-----KAVAGLPSGSAG 1296
SP P+ + P + + GT P+ P P P + A L S
Sbjct: 65 SPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIA 124
Query: 1297 PSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAA--- 1353
P+ +P+ P AL P S+ S A PP ++ PP A A + +
Sbjct: 125 PTLKGTPSSSAPLALVAL--APHSVQKSSAFPP-------NLLTSPPSVAVAESGSVITL 175
Query: 1354 AAPPAPPE 1361
+AP AP E
Sbjct: 176 SAPIAPSE 183
Score = 32.3 bits (72), Expect = 3.4
Identities = 52/204 (25%), Positives = 69/204 (33%), Gaps = 58/204 (28%)
Query: 713 GPPGPSSPMSRSQEYLLDEGPAPGTPPREAR------PGRHGHSIKRASVPPVPGKPRQV 766
G PGP+ P S PAP P A P + VP
Sbjct: 39 GQPGPTLPPPCS--------PAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTA 90
Query: 767 LPPGTSHFTPPQTPTKTRPGSPQALGGPHGPAP---ATAKVKPTPQLLPPTERPMS---- 819
LP GT+ P+ PT P +G P PA A+ + PT + P + P++
Sbjct: 91 LPLGTA----PEAPTFL----PNLIGPPISPAALALASPMIAPTLKGTPSSSAPLALVAL 142
Query: 820 -----------PRSLPQSP-----THRGFAYVLPQP------------VEGEVGPAAPG- 850
P +L SP G L P V EV P G
Sbjct: 143 APHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKTNLNKVPSEVVPNPKGT 202
Query: 851 PAPPPVPTAVPTLCLPPEADAEPG 874
P+PP + + VP C+ P A + G
Sbjct: 203 PSPPCIVSTVPYHCVTPMASIQSG 226
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 120 bits (302), Expect = 7e-27
Identities = 100/332 (30%), Positives = 152/332 (45%), Gaps = 37/332 (11%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLL 69
A + +D +A LLQ + K+ VN GF+ LH AA GN + +LLL
Sbjct: 178 AARKDDTKSAALLLQNDHNADVQ-----SKMMVNRTTESGFTPLHIAAHYGNVNVATLLL 232
Query: 70 EAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYD 129
AAVD G+ PLH A+ +G +KL+L G ++ + +G PLH AA+ GH
Sbjct: 233 NRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQ 292
Query: 130 VSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSS------------------- 170
V E+LL+ + +G +PL +A + V V+ LL
Sbjct: 293 VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 352
Query: 171 -----NMCAALLEPRPG-DATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-T 223
+ LL+ R +A NG +PLH+A K I ++ LL++ G I T+SG T
Sbjct: 353 HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLT 412
Query: 224 ALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAA 283
+H AA G +V LLL +G + V N +TAL H + ++ LLR A
Sbjct: 413 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL---HMAARAGQVEVVRCLLRN-GAL 468
Query: 284 LQVRATKDYCNNYDLTSLNVKAGDIITVLEQH 315
+ RA ++ + + L +I+ +L QH
Sbjct: 469 VDARAREEQTPLHIASRLG--KTEIVQLLLQH 498
Score = 114 bits (286), Expect = 5e-25
Identities = 80/269 (29%), Positives = 136/269 (50%), Gaps = 23/269 (8%)
Query: 49 GFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAV 108
G + +H AA G+ ++ LLL+ A+ D+ + +G LH AA G+ E ++ +L+ G+ V
Sbjct: 410 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 469
Query: 109 NIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLL 168
+ + E PLH+A++ G ++ ++LLQH ++P +G TPL ++ G+V V +LL
Sbjct: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 529
Query: 169 SSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHE 227
+ +L + G +PLH+AAK G +D+ +LLLQ + K+G T LH
Sbjct: 530 EAGAAHSLATKK--------GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 581
Query: 228 AALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVR 287
AA +V LLL+ G + H T L I + K ++ AS L
Sbjct: 582 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK----------KNQMQIASTLLNYG 631
Query: 288 ATKDYCNNYDLTSLNVKA----GDIITVL 312
A + +T L++ + D++T+L
Sbjct: 632 AETNIVTKQGVTPLHLASQEGHTDMVTLL 660
Score = 114 bits (285), Expect = 7e-25
Identities = 85/278 (30%), Positives = 132/278 (47%), Gaps = 34/278 (12%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
I++N + +G +ALH AA G+ L+ LL ++VD KG LH A+ G+ E +K
Sbjct: 34 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 93
Query: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFG 159
+++K G+ +N S G PL++AAQ H DV + LL++ +N G TPL +A + G
Sbjct: 94 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 153
Query: 160 RVGVVQLLLSSN-------------------MCAALLEPRPGDA----------TDPNGT 190
V +LL ++ AALL +A T +G
Sbjct: 154 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 213
Query: 191 SPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHV 249
+PLH+AA G++++ LLL G ++ ++G T LH A+ G T +V+LLLD G
Sbjct: 214 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 273
Query: 250 RNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVR 287
+ T L ++ +LL E A L R
Sbjct: 274 KTRDGLTPL----HCAARSGHDQVVELLLERGAPLLAR 307
Score = 112 bits (281), Expect = 2e-24
Identities = 78/235 (33%), Positives = 123/235 (52%), Gaps = 19/235 (8%)
Query: 31 AKLLGSTKKINVNFQD---PD-----GFSALHHAALNGNTELISLLLEAQAAVDIKDNKG 82
A LG T+ + + Q PD G++ LH +A G ++ S+LLEA AA + KG
Sbjct: 483 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 542
Query: 83 MRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPC 142
PLH AA G + KL+L+ +A + G PLH+AA + + V+ +LL+ ++P
Sbjct: 543 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 602
Query: 143 MVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHI 202
+G TPL +A + ++ + LL+ ++ + G +PLHLA++ GH
Sbjct: 603 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ--------GVTPLHLASQEGHT 654
Query: 203 DIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGI--NAHVRNTYS 254
D++ LLL G +I+ TKSG T+LH AA K V +L G +AH + Y+
Sbjct: 655 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 709
Score = 109 bits (273), Expect = 2e-23
Identities = 76/248 (30%), Positives = 115/248 (46%), Gaps = 9/248 (3%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
+G + LH AA N ++ LLLE A+ G PLH AA + + + +L G+
Sbjct: 574 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 633
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
NI + +G PLHLA+Q GH D+ +LL +N M SG T L LA + +V V +L
Sbjct: 634 TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 693
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
DA G +PL +A G++ ++ LL+ G ++N +TK+G T LH
Sbjct: 694 TKHGA--------DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 745
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQV 286
+AA G T ++ +LL G + TAL I + +K + E +
Sbjct: 746 QAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTT 805
Query: 287 RATKDYCN 294
K N
Sbjct: 806 ITEKHKLN 813
Score = 102 bits (255), Expect = 2e-21
Identities = 71/212 (33%), Positives = 106/212 (50%), Gaps = 9/212 (4%)
Query: 30 KAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYA 89
K LL K + + +G++ LH AA ++ S LL A +I +G+ PLH A
Sbjct: 589 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 648
Query: 90 AWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGK 149
+ +G + + L+L G+ +++ + G LHLAAQ +V+++L +H ++ G
Sbjct: 649 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 708
Query: 150 TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209
TPL +AC +G V +V LL +A NG +PLH AA+ GH II +LL
Sbjct: 709 TPLIVACHYGNVKMVNFLLKQGANV--------NAKTKNGYTPLHQAAQQGHTHIINVLL 760
Query: 210 QAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240
Q G N T +G TAL A G VV L
Sbjct: 761 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 792
Score = 61.6 bits (148), Expect = 5e-09
Identities = 40/105 (38%), Positives = 57/105 (54%), Gaps = 6/105 (5%)
Query: 188 NGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGIN 246
NG + LHLAAK GH+ +++ LL G ++ TK G TALH A+L G+ EVV++L+ G N
Sbjct: 42 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 101
Query: 247 AHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKD 291
N SQ ++ +K LL + A Q AT+D
Sbjct: 102 I---NAQSQNGFTPLYMAAQENHIDVVKYLLE--NGANQSTATED 141
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 120 bits (302), Expect = 7e-27
Identities = 100/332 (30%), Positives = 152/332 (45%), Gaps = 37/332 (11%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLL 69
A + +D +A LLQ + K+ VN GF+ LH AA GN + +LLL
Sbjct: 199 AARKDDTKSAALLLQNDHNADVQ-----SKMMVNRTTESGFTPLHIAAHYGNVNVATLLL 253
Query: 70 EAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYD 129
AAVD G+ PLH A+ +G +KL+L G ++ + +G PLH AA+ GH
Sbjct: 254 NRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQ 313
Query: 130 VSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSS------------------- 170
V E+LL+ + +G +PL +A + V V+ LL
Sbjct: 314 VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 373
Query: 171 -----NMCAALLEPRPG-DATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-T 223
+ LL+ R +A NG +PLH+A K I ++ LL++ G I T+SG T
Sbjct: 374 HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLT 433
Query: 224 ALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAA 283
+H AA G +V LLL +G + V N +TAL H + ++ LLR A
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL---HMAARAGQVEVVRCLLRN-GAL 489
Query: 284 LQVRATKDYCNNYDLTSLNVKAGDIITVLEQH 315
+ RA ++ + + L +I+ +L QH
Sbjct: 490 VDARAREEQTPLHIASRLG--KTEIVQLLLQH 519
Score = 114 bits (286), Expect = 5e-25
Identities = 80/269 (29%), Positives = 136/269 (50%), Gaps = 23/269 (8%)
Query: 49 GFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAV 108
G + +H AA G+ ++ LLL+ A+ D+ + +G LH AA G+ E ++ +L+ G+ V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 109 NIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLL 168
+ + E PLH+A++ G ++ ++LLQH ++P +G TPL ++ G+V V +LL
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550
Query: 169 SSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHE 227
+ +L + G +PLH+AAK G +D+ +LLLQ + K+G T LH
Sbjct: 551 EAGAAHSLATKK--------GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602
Query: 228 AALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVR 287
AA +V LLL+ G + H T L I + K ++ AS L
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK----------KNQMQIASTLLNYG 652
Query: 288 ATKDYCNNYDLTSLNVKA----GDIITVL 312
A + +T L++ + D++T+L
Sbjct: 653 AETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 114 bits (285), Expect = 7e-25
Identities = 85/278 (30%), Positives = 132/278 (47%), Gaps = 34/278 (12%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
I++N + +G +ALH AA G+ L+ LL ++VD KG LH A+ G+ E +K
Sbjct: 55 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 114
Query: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFG 159
+++K G+ +N S G PL++AAQ H DV + LL++ +N G TPL +A + G
Sbjct: 115 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174
Query: 160 RVGVVQLLLSSN-------------------MCAALLEPRPGDA----------TDPNGT 190
V +LL ++ AALL +A T +G
Sbjct: 175 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 234
Query: 191 SPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHV 249
+PLH+AA G++++ LLL G ++ ++G T LH A+ G T +V+LLLD G
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 250 RNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVR 287
+ T L ++ +LL E A L R
Sbjct: 295 KTRDGLTPL----HCAARSGHDQVVELLLERGAPLLAR 328
Score = 112 bits (281), Expect = 2e-24
Identities = 78/235 (33%), Positives = 123/235 (52%), Gaps = 19/235 (8%)
Query: 31 AKLLGSTKKINVNFQD---PD-----GFSALHHAALNGNTELISLLLEAQAAVDIKDNKG 82
A LG T+ + + Q PD G++ LH +A G ++ S+LLEA AA + KG
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Query: 83 MRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPC 142
PLH AA G + KL+L+ +A + G PLH+AA + + V+ +LL+ ++P
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623
Query: 143 MVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHI 202
+G TPL +A + ++ + LL+ ++ + G +PLHLA++ GH
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ--------GVTPLHLASQEGHT 675
Query: 203 DIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGI--NAHVRNTYS 254
D++ LLL G +I+ TKSG T+LH AA K V +L G +AH + Y+
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730
Score = 109 bits (273), Expect = 2e-23
Identities = 76/248 (30%), Positives = 115/248 (46%), Gaps = 9/248 (3%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
+G + LH AA N ++ LLLE A+ G PLH AA + + + +L G+
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
NI + +G PLHLA+Q GH D+ +LL +N M SG T L LA + +V V +L
Sbjct: 655 TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
DA G +PL +A G++ ++ LL+ G ++N +TK+G T LH
Sbjct: 715 TKHGA--------DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 766
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQV 286
+AA G T ++ +LL G + TAL I + +K + E +
Sbjct: 767 QAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTT 826
Query: 287 RATKDYCN 294
K N
Sbjct: 827 ITEKHKLN 834
Score = 102 bits (255), Expect = 2e-21
Identities = 71/212 (33%), Positives = 106/212 (50%), Gaps = 9/212 (4%)
Query: 30 KAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYA 89
K LL K + + +G++ LH AA ++ S LL A +I +G+ PLH A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 90 AWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGK 149
+ +G + + L+L G+ +++ + G LHLAAQ +V+++L +H ++ G
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 150 TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209
TPL +AC +G V +V LL +A NG +PLH AA+ GH II +LL
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANV--------NAKTKNGYTPLHQAAQQGHTHIINVLL 781
Query: 210 QAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240
Q G N T +G TAL A G VV L
Sbjct: 782 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 61.6 bits (148), Expect = 5e-09
Identities = 40/105 (38%), Positives = 57/105 (54%), Gaps = 6/105 (5%)
Query: 188 NGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGIN 246
NG + LHLAAK GH+ +++ LL G ++ TK G TALH A+L G+ EVV++L+ G N
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 247 AHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKD 291
N SQ ++ +K LL + A Q AT+D
Sbjct: 123 I---NAQSQNGFTPLYMAAQENHIDVVKYLLE--NGANQSTATED 162
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 120 bits (302), Expect = 7e-27
Identities = 100/332 (30%), Positives = 152/332 (45%), Gaps = 37/332 (11%)
Query: 10 AVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLL 69
A + +D +A LLQ + K+ VN GF+ LH AA GN + +LLL
Sbjct: 199 AARKDDTKSAALLLQNDHNADVQ-----SKMMVNRTTESGFTPLHIAAHYGNVNVATLLL 253
Query: 70 EAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYD 129
AAVD G+ PLH A+ +G +KL+L G ++ + +G PLH AA+ GH
Sbjct: 254 NRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQ 313
Query: 130 VSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSS------------------- 170
V E+LL+ + +G +PL +A + V V+ LL
Sbjct: 314 VVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAA 373
Query: 171 -----NMCAALLEPRPG-DATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-T 223
+ LL+ R +A NG +PLH+A K I ++ LL++ G I T+SG T
Sbjct: 374 HCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLT 433
Query: 224 ALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAA 283
+H AA G +V LLL +G + V N +TAL H + ++ LLR A
Sbjct: 434 PIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETAL---HMAARAGQVEVVRCLLRN-GAL 489
Query: 284 LQVRATKDYCNNYDLTSLNVKAGDIITVLEQH 315
+ RA ++ + + L +I+ +L QH
Sbjct: 490 VDARAREEQTPLHIASRLG--KTEIVQLLLQH 519
Score = 114 bits (286), Expect = 5e-25
Identities = 80/269 (29%), Positives = 136/269 (50%), Gaps = 23/269 (8%)
Query: 49 GFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAV 108
G + +H AA G+ ++ LLL+ A+ D+ + +G LH AA G+ E ++ +L+ G+ V
Sbjct: 431 GLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 109 NIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLL 168
+ + E PLH+A++ G ++ ++LLQH ++P +G TPL ++ G+V V +LL
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550
Query: 169 SSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHE 227
+ +L + G +PLH+AAK G +D+ +LLLQ + K+G T LH
Sbjct: 551 EAGAAHSLATKK--------GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602
Query: 228 AALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVR 287
AA +V LLL+ G + H T L I + K ++ AS L
Sbjct: 603 AAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAK----------KNQMQIASTLLNYG 652
Query: 288 ATKDYCNNYDLTSLNVKA----GDIITVL 312
A + +T L++ + D++T+L
Sbjct: 653 AETNIVTKQGVTPLHLASQEGHTDMVTLL 681
Score = 114 bits (285), Expect = 7e-25
Identities = 85/278 (30%), Positives = 132/278 (47%), Gaps = 34/278 (12%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
I++N + +G +ALH AA G+ L+ LL ++VD KG LH A+ G+ E +K
Sbjct: 55 IDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVK 114
Query: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFG 159
+++K G+ +N S G PL++AAQ H DV + LL++ +N G TPL +A + G
Sbjct: 115 VLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174
Query: 160 RVGVVQLLLSSN-------------------MCAALLEPRPGDA----------TDPNGT 190
V +LL ++ AALL +A T +G
Sbjct: 175 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGF 234
Query: 191 SPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHV 249
+PLH+AA G++++ LLL G ++ ++G T LH A+ G T +V+LLLD G
Sbjct: 235 TPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDA 294
Query: 250 RNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVR 287
+ T L ++ +LL E A L R
Sbjct: 295 KTRDGLTPL----HCAARSGHDQVVELLLERGAPLLAR 328
Score = 112 bits (281), Expect = 2e-24
Identities = 78/235 (33%), Positives = 123/235 (52%), Gaps = 19/235 (8%)
Query: 31 AKLLGSTKKINVNFQD---PD-----GFSALHHAALNGNTELISLLLEAQAAVDIKDNKG 82
A LG T+ + + Q PD G++ LH +A G ++ S+LLEA AA + KG
Sbjct: 504 ASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKG 563
Query: 83 MRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPC 142
PLH AA G + KL+L+ +A + G PLH+AA + + V+ +LL+ ++P
Sbjct: 564 FTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPH 623
Query: 143 MVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHI 202
+G TPL +A + ++ + LL+ ++ + G +PLHLA++ GH
Sbjct: 624 ATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQ--------GVTPLHLASQEGHT 675
Query: 203 DIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGI--NAHVRNTYS 254
D++ LLL G +I+ TKSG T+LH AA K V +L G +AH + Y+
Sbjct: 676 DMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730
Score = 109 bits (273), Expect = 2e-23
Identities = 76/248 (30%), Positives = 115/248 (46%), Gaps = 9/248 (3%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
+G + LH AA N ++ LLLE A+ G PLH AA + + + +L G+
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
NI + +G PLHLA+Q GH D+ +LL +N M SG T L LA + +V V +L
Sbjct: 655 TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADIL 714
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
DA G +PL +A G++ ++ LL+ G ++N +TK+G T LH
Sbjct: 715 TKHGA--------DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLH 766
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQV 286
+AA G T ++ +LL G + TAL I + +K + E +
Sbjct: 767 QAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTT 826
Query: 287 RATKDYCN 294
K N
Sbjct: 827 ITEKHKLN 834
Score = 102 bits (255), Expect = 2e-21
Identities = 71/212 (33%), Positives = 106/212 (50%), Gaps = 9/212 (4%)
Query: 30 KAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYA 89
K LL K + + +G++ LH AA ++ S LL A +I +G+ PLH A
Sbjct: 610 KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLA 669
Query: 90 AWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGK 149
+ +G + + L+L G+ +++ + G LHLAAQ +V+++L +H ++ G
Sbjct: 670 SQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGY 729
Query: 150 TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209
TPL +AC +G V +V LL +A NG +PLH AA+ GH II +LL
Sbjct: 730 TPLIVACHYGNVKMVNFLLKQGANV--------NAKTKNGYTPLHQAAQQGHTHIINVLL 781
Query: 210 QAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240
Q G N T +G TAL A G VV L
Sbjct: 782 QHGAKPNATTANGNTALAIAKRLGYISVVDTL 813
Score = 61.6 bits (148), Expect = 5e-09
Identities = 40/105 (38%), Positives = 57/105 (54%), Gaps = 6/105 (5%)
Query: 188 NGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGIN 246
NG + LHLAAK GH+ +++ LL G ++ TK G TALH A+L G+ EVV++L+ G N
Sbjct: 63 NGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGAN 122
Query: 247 AHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKD 291
N SQ ++ +K LL + A Q AT+D
Sbjct: 123 I---NAQSQNGFTPLYMAAQENHIDVVKYLLE--NGANQSTATED 162
Score = 55.8 bits (133), Expect = 3e-07
Identities = 89/383 (23%), Positives = 128/383 (33%), Gaps = 82/383 (21%)
Query: 1074 LATARRGPGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQN 1133
LA R E D P T +Q K G++ P ++R+++ KQ
Sbjct: 1669 LAVGRSSEKEGKDIPPDETQSTQKQH-----KPSLGIKKP----------VRRKLKEKQK 1713
Query: 1134 QQENVKFILTESDTVKRRPK----AKEREAGPEPPP------------PLSVYHNGTGTV 1177
Q+E E +K+ ++ PEP P P+ + +
Sbjct: 1714 QKEEGLQASAEKAELKKGSSEESLGEDPGLAPEPLPTVKATSPLIEETPIGSIKDKVKAL 1773
Query: 1178 RRRPASEQAGPPELP---------------PPPPPAEPPPTDLAHLPPLPPPEGE----- 1217
++R EQ G +LP P P A P H P P P+ E
Sbjct: 1774 QKRVEDEQKGRSKLPIRVKGKEDVPKKTTHRPHPAASPSLKSERHAPGSPSPKTERHSTL 1833
Query: 1218 ---ARKPAKPPVSP-----KPVLTQPVPKLQG-SPTPTSKKVPLPGPGSPEVKRAHGTPP 1268
A+ PPVSP K P K + SP +S K P SP K +P
Sbjct: 1834 SSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPV 1893
Query: 1269 PVSPKPPPPPTAP--KPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPA 1326
+ PP +P K K PSG P SP R P G
Sbjct: 1894 SSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGR-----TDKH 1948
Query: 1327 KPPS-PGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSAC--LAAA 1383
+P S G H+P P + PP P S +++EET + L A
Sbjct: 1949 QPVSTAGKTEKHLPVSP------SGKTEKQPPVSP------TSKTERIEETMSVRELMKA 1996
Query: 1384 LQAVEEKIRQEDAQGPRDSAAEK 1406
Q+ ++ + + SA +K
Sbjct: 1997 FQSGQDPSKHKTGLFEHKSAKQK 2019
Score = 43.5 bits (101), Expect = 0.001
Identities = 62/253 (24%), Positives = 86/253 (33%), Gaps = 39/253 (15%)
Query: 587 TKLGHQKKLMLAVRKLAELQKAEYAKYEGGPLRRKAPQSLEVMAIESPPPPEPTPADCQ- 645
T +G K + A++K E ++ +K P+R K + + P P +
Sbjct: 1761 TPIGSIKDKVKALQKRVEDEQKGRSKL---PIRVKGKEDVPKKTTHRPHPAASPSLKSER 1817
Query: 646 ----SPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRAR 701
SP T + S LS + P TEK H P +P A T + S
Sbjct: 1818 HAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEK---HSPVSPSAKTERHSPA----- 1869
Query: 702 HMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARP-GRHGHSIKRASVPPVP 760
SSS + P PS+ R P T P G + KR PPV
Sbjct: 1870 --SSSSKTEKHSPVSPSTKTER-------HSPVSSTKTERHPPVSPSGKTDKR---PPVS 1917
Query: 761 GKPRQVLPPGTSHFTPPQTPTKTR---PGSPQALGGPHGPAPATAKVKPTPQLLPPTERP 817
P G + PP +P +T P SP H P K + + P +
Sbjct: 1918 -------PSGRTEKHPPVSPGRTEKRLPVSPSGRTDKHQPVSTAGKTEKHLPVSPSGKTE 1970
Query: 818 MSPRSLPQSPTHR 830
P P S T R
Sbjct: 1971 KQPPVSPTSKTER 1983
Score = 32.7 bits (73), Expect = 2.6
Identities = 66/331 (19%), Positives = 113/331 (34%), Gaps = 54/331 (16%)
Query: 849 PGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYA 908
PG AP P+PT T L E G K + +L + D + R +L + G
Sbjct: 1741 PGLAPEPLPTVKATSPLIEETPI--GSIKDKVKALQK-RVEDEQKGRSKLPI-RVKGKED 1796
Query: 909 TVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVP 968
++ R H +P +++ + P P PK + S++ E P
Sbjct: 1797 VPKKTTHRPHPAASP-------------SLKSERHAPGSPSPKTERHSTLSSSAKTERHP 1843
Query: 969 DAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPP---- 1024
P ++ + S ++ S T S + + S + + R P
Sbjct: 1844 PVSPS-------SKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSST 1896
Query: 1025 --EGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPG 1082
E HP P SP + + P G G L + G
Sbjct: 1897 KTERHP---PVSPS--------GKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSPSGRT 1945
Query: 1083 ESADPGPFVEDGTGRQRPRGPS-KGEAGVEGPPLAK---VEASATLKRRIRAKQNQQENV 1138
+ P T + P PS K E P +K +E + +++ ++A Q+ Q+
Sbjct: 1946 DKHQP-VSTAGKTEKHLPVSPSGKTEKQPPVSPTSKTERIEETMSVRELMKAFQSGQDPS 2004
Query: 1139 KF---ILTESDTVKRRPKAK-----EREAGP 1161
K + +++P+ K E+E GP
Sbjct: 2005 KHKTGLFEHKSAKQKQPQEKGKVRVEKEKGP 2035
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 119 bits (299), Expect = 2e-26
Identities = 79/224 (35%), Positives = 119/224 (53%), Gaps = 9/224 (4%)
Query: 38 KKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEP 97
KK +VNFQD + + LH AA G+ E+I LL+ + A V+ KD+K + PLH A +E
Sbjct: 30 KKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEEA 89
Query: 98 MKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACE 157
++++LK + VN PLH+AA + +E L+ SN + D +G+T L A
Sbjct: 90 VQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAF 149
Query: 158 FGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDIN- 216
G +V+LLLS +A D +H AA GHI++++LL+ G ++
Sbjct: 150 SGHGEMVKLLLSRGANI--------NAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTC 201
Query: 217 RQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
+ KS T LH AA G VV+ LLD G++ + N Y T L +
Sbjct: 202 KDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHV 245
Score = 108 bits (271), Expect = 3e-23
Identities = 70/221 (31%), Positives = 117/221 (52%), Gaps = 10/221 (4%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKE-PM 98
+++N + G + LH A NG +++ L++ A V+ K+ KG PLH+AA +
Sbjct: 230 VDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCL 289
Query: 99 KLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEF 158
+L++ G+ VN+ S +G PLH+ A HG + S+ ++Q + D +G TPL +A +
Sbjct: 290 ELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARY 349
Query: 159 GRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQ 218
G ++ L++S A +G PLHLAA +G D R LL +G DI+
Sbjct: 350 GHELLINTLITSGADTA--------KRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTP 401
Query: 219 TKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTAL 258
G T LH AA G E + LLL++G + + ++ + ++ L
Sbjct: 402 DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPL 442
Score = 105 bits (262), Expect = 3e-22
Identities = 100/346 (28%), Positives = 151/346 (43%), Gaps = 57/346 (16%)
Query: 33 LLGSTKKIN-VNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAW 91
L+G+ + N V+ QD +G + L + LNG+T+ + LL A VD KD G LH A
Sbjct: 636 LIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAV 695
Query: 92 QGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQH----QSNPCMVDNS 147
G +E + +L+ G+ + G P+HL+A GH V LLQ +NP DN
Sbjct: 696 TGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNH 755
Query: 148 GKTPLDLACEFGRVGVVQLLLS------------SNMCAALLEPRPG------------- 182
G T L AC G V+LLL S + A++ G
Sbjct: 756 GYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASI 815
Query: 183 -DATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLL 240
+ATD G +PLH AA H++ ++LLL +N +G T L AA G+T V +L
Sbjct: 816 VNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEML 875
Query: 241 LDSG-----INAHVRNTYSQTALDIVHQFTTSQASREI--KQLLREASAALQVRATKDYC 293
+ S + + +NT A H+ + +I + L+ +AALQ
Sbjct: 876 VSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQ-------- 927
Query: 294 NNYDLTSLNVKAGDIITVLEQHPDGRWKGCIHDNRTGNDRVGYFPS 339
T L+V A + +T++ Q G+ + D GY P+
Sbjct: 928 -----TPLHVAARNGLTMVVQELLGKGASVL-----AVDENGYTPA 963
Score = 102 bits (253), Expect = 3e-21
Identities = 91/305 (29%), Positives = 140/305 (45%), Gaps = 49/305 (16%)
Query: 41 NVNFQDPDGFSALHHAALNGNT-ELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
+VN D G + LH+AA + + + LL A I+D +G +HY+A G + ++
Sbjct: 463 SVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCLQ 522
Query: 100 L--------VLKAGSAVNIPSDEGH----IPLHLAAQHGHYDVSEMLLQHQSNPCMVDNS 147
L VL S ++ SD + PLHLAA HGH+ E+L+Q + + ++S
Sbjct: 523 LIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSS 582
Query: 148 GKTPLDLACEFGRVGVVQLLLSS------------------------NMCAALL----EP 179
G+TPLDLA G V V +L++ + C LL EP
Sbjct: 583 GRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRLLIGNAEP 642
Query: 180 RPG-DATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVV 237
+ D D NG +PL L+ NGH D + LL G +++ + K G TALH A+ G E V
Sbjct: 643 QNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECV 702
Query: 238 RLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYD 297
LL G +R++ +T + + S A I L +A + A +N+
Sbjct: 703 DALLQHGAKCLLRDSRGRTPIHL------SAACGHIGVLGALLQSAASMDANPATADNHG 756
Query: 298 LTSLN 302
T+L+
Sbjct: 757 YTALH 761
Score = 99.0 bits (245), Expect = 3e-20
Identities = 75/253 (29%), Positives = 112/253 (44%), Gaps = 43/253 (16%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
N+N D A+H AA G+ E++ LL+ A V KD K PLH AA G +K
Sbjct: 165 NINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKY 224
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHG--------------------------HYDVS--- 131
+L G +N P+ G+ PLH+A +G H+ +
Sbjct: 225 LLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTH 284
Query: 132 -----EMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATD 186
E+L+ + ++ M GKTPL + GR Q ++ S D D
Sbjct: 285 GALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVI--------DCED 336
Query: 187 PNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGT-ALHEAALCGKTEVVRLLLDSGI 245
NG +PLH+AA+ GH +I L+ +G D ++ G LH AAL G ++ R LL SG
Sbjct: 337 KNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGF 396
Query: 246 NAHVRNTYSQTAL 258
+ + + +T L
Sbjct: 397 DIDTPDDFGRTCL 409
Score = 97.4 bits (241), Expect = 8e-20
Identities = 63/194 (32%), Positives = 99/194 (51%), Gaps = 7/194 (3%)
Query: 53 LHHAALNGNTELISLLL---EAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVN 109
+H AA NG++E + LL+ E Q AVDI+D G PL + G + + +L G+ V+
Sbjct: 621 IHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVD 680
Query: 110 IPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLS 169
G LH A GH + + LLQH + + D+ G+TP+ L+ G +GV+ LL
Sbjct: 681 AKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQ 740
Query: 170 SNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAA 229
S AA ++ P A D +G + LH A NGH + LLL+ + + + + LH A
Sbjct: 741 S---AASMDANPATA-DNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNAFSPLHCAV 796
Query: 230 LCGKTEVVRLLLDS 243
+ +L+D+
Sbjct: 797 INDNEGAAEMLIDT 810
Score = 92.0 bits (227), Expect = 4e-18
Identities = 70/229 (30%), Positives = 114/229 (49%), Gaps = 16/229 (6%)
Query: 52 ALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIP 111
+L A NG+ + + L+ + V+ +DN+ PLH AA+ G E ++L++ +G+ VN
Sbjct: 11 SLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAK 70
Query: 112 SDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL--LS 169
+ PLH A + ++LL+H ++ D + +TPL +A V + L L
Sbjct: 71 DSKWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLL 130
Query: 170 SNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINR-QTKSGTALHEA 228
SN+ + +D G + LH AA +GH ++++LLL G +IN K A+H A
Sbjct: 131 SNV----------NVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA 180
Query: 229 ALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLL 277
A G EVV+LL+ G ++ S T L H +S +K LL
Sbjct: 181 AYMGHIEVVKLLVSHGAEVTCKDKKSYTPL---HAAASSGMISVVKYLL 226
Score = 80.5 bits (197), Expect = 1e-14
Identities = 63/220 (28%), Positives = 99/220 (45%), Gaps = 10/220 (4%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
+VN + DG + LH AL+G ++++ A +D +D G PLH AA G + +
Sbjct: 298 DVNMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT 357
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
++ +G+ G PLHLAA G D LL + D+ G+T L A G
Sbjct: 358 LITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGN 417
Query: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTK 220
+ + LLL++ + D G SPLH AA N + + L+ +G +N +
Sbjct: 418 LECLNLLLNTG--------ADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDE 469
Query: 221 SG-TALHEAALCGKT-EVVRLLLDSGINAHVRNTYSQTAL 258
G T LH AA + + LL + N +R+ A+
Sbjct: 470 RGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAV 509
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 119 bits (299), Expect = 2e-26
Identities = 89/299 (29%), Positives = 137/299 (45%), Gaps = 30/299 (10%)
Query: 19 AQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIK 78
A + R KA L N + + GF+ LH AA GN + +LLL AAVD
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264
Query: 79 DNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQ 138
+ PLH A+ +G +KL+L G+ ++ + +G PLH A+ GH V EMLL
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324
Query: 139 SNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSN------------------------MCA 174
+ +G +PL +A + + VQLLL N +
Sbjct: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAK 384
Query: 175 ALLEPRPG-DATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCG 232
LL+ + +A NG +PLH+A K I ++ LLL+ G I T+SG T +H AA G
Sbjct: 385 VLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMG 444
Query: 233 KTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKD 291
+V L+ G + + N +TAL H S + ++ L+++ A ++ +A D
Sbjct: 445 HVNIVSQLMHHGASPNTTNVRGETAL---HMAARSGQAEVVRYLVQD-GAQVEAKAKDD 499
Score = 119 bits (299), Expect = 2e-26
Identities = 80/241 (33%), Positives = 120/241 (49%), Gaps = 26/241 (10%)
Query: 49 GFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAV 108
G +ALH AA +G E++ L++ A V+ K PLH +A G+ + ++ +L+ G++
Sbjct: 466 GETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASP 525
Query: 109 NIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLL 168
N + G+ PLHL+A+ GH DV+ LL H ++ + G TPL +A ++G++ V LLL
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585
Query: 169 S----------------------SNMCAALLEPRPG---DATDPNGTSPLHLAAKNGHID 203
N ALL G A NG +PLH+AAK +D
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMD 645
Query: 204 IIRLLLQAGIDINRQTKSGTA-LHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVH 262
I LL+ G D N T+ G A +H AA G ++V LLL N ++ N T L +
Sbjct: 646 IATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAA 705
Query: 263 Q 263
Q
Sbjct: 706 Q 706
Score = 115 bits (288), Expect = 3e-25
Identities = 81/267 (30%), Positives = 133/267 (49%), Gaps = 25/267 (9%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
+++N + +G +ALH A+ G+ E++S LL+ +A VD KG LH A+ G+ E +K
Sbjct: 65 VDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVK 124
Query: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFG 159
+++ G+ VN S G PL++AAQ H +V + LL + ++ + G TPL +A + G
Sbjct: 125 VLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQG 184
Query: 160 RVGVVQLLLSSN-------------------MCAALL--EPRPGDATDPNGTSPLHLAAK 198
VV LLL ++ AALL D +G +PLH+AA
Sbjct: 185 HDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAH 244
Query: 199 NGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTA 257
G+I++ LLL ++ ++ T LH A+ G +V+LLLD G + ++
Sbjct: 245 YGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAK---TRDG 301
Query: 258 LDIVHQFTTSQASREIKQLLREASAAL 284
L +H S + ++ LL A+ L
Sbjct: 302 LTPLHCGARSGHEQVVEMLLDRAAPIL 328
Score = 112 bits (279), Expect = 3e-24
Identities = 81/259 (31%), Positives = 129/259 (49%), Gaps = 19/259 (7%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
D +ALH AA G+ ++ +LL+ +A + K G PLH A + R + M+L+LK G++
Sbjct: 366 DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGAS 425
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
+ ++ G P+H+AA GH ++ L+ H ++P + G+T L +A G+ VV+ L
Sbjct: 426 IQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYL 485
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
+ A +E + D +PLH++A+ G DI++ LLQ G N T SG T LH
Sbjct: 486 VQD---GAQVEAKAKD-----DQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLH 537
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQV 286
+A G +V LLD G + + T L + ++ L A+ LQ
Sbjct: 538 LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGK----------LEVANLLLQK 587
Query: 287 RATKDYCNNYDLTSLNVKA 305
A+ D LT L+V A
Sbjct: 588 SASPDAAGKSGLTPLHVAA 606
Score = 110 bits (276), Expect = 7e-24
Identities = 71/216 (32%), Positives = 110/216 (50%), Gaps = 9/216 (4%)
Query: 49 GFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAV 108
G + LH AA N ++ LLL+ A+ G PLH AA + + + +L+ G+
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA 657
Query: 109 NIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLL 168
N + +G +HLAAQ GH D+ +LL +N + + SG TPL LA + RV V ++L+
Sbjct: 658 NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717
Query: 169 SSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHE 227
+ DA G +PLH+ G+I I+ LLQ +N +TK+G T LH+
Sbjct: 718 NQGAHV--------DAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQ 769
Query: 228 AALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQ 263
AA G T ++ +LL + + + TAL I +
Sbjct: 770 AAQQGHTHIINVLLQNNASPNELTVNGNTALGIARR 805
Score = 108 bits (270), Expect = 4e-23
Identities = 73/256 (28%), Positives = 118/256 (46%), Gaps = 13/256 (5%)
Query: 38 KKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEP 97
KK N N + +GF+ LH A +++ LLL+ A++ G+ P+H AA+ G
Sbjct: 389 KKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNI 448
Query: 98 MKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACE 157
+ ++ G++ N + G LH+AA+ G +V L+Q + +TPL ++
Sbjct: 449 VSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISAR 508
Query: 158 FGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINR 217
G+ +VQ LL +A +G +PLHL+A+ GH D+ LL G ++
Sbjct: 509 LGKADIVQQLLQQGASP--------NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSI 560
Query: 218 QTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQL 276
TK G T LH AA GK EV LLL + T L + + ++++ L
Sbjct: 561 TTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYD----NQKVALL 616
Query: 277 LREASAALQVRATKDY 292
L + A+ A Y
Sbjct: 617 LLDQGASPHAAAKNGY 632
Score = 108 bits (269), Expect = 5e-23
Identities = 87/272 (31%), Positives = 135/272 (49%), Gaps = 27/272 (9%)
Query: 37 TKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKE 96
T NVN Q +GF+ L+ AA + E++ LL+ A+ + G PL A QG +
Sbjct: 128 TNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQ 187
Query: 97 PMKLVLK--AGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDL 154
+ L+L+ V +P+ LH+AA+ + +LLQ+ +N + SG TPL +
Sbjct: 188 VVSLLLENDTKGKVRLPA------LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHI 241
Query: 155 ACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGID 214
A +G + V LLL N AA+ D T N +PLH+A+K G+ ++++LLL G
Sbjct: 242 AAHYGNINVATLLL--NRAAAV------DFTARNDITPLHVASKRGNANMVKLLLDRGAK 293
Query: 215 INRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREI 273
I+ +T+ G T LH A G +VV +LLD A + ++ L +H T +
Sbjct: 294 IDAKTRDGLTPLHCGARSGHEQVVEMLLD---RAAPILSKTKNGLSPLHMATQGDHLNCV 350
Query: 274 KQLLREASAALQVRATKDYCNNYDLTSLNVKA 305
+ LL+ V T DY LT+L+V A
Sbjct: 351 QLLLQHNVPVDDV--TNDY-----LTALHVAA 375
Score = 105 bits (262), Expect = 3e-22
Identities = 65/219 (29%), Positives = 110/219 (50%), Gaps = 9/219 (4%)
Query: 43 NFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102
N G++ LH +A G+ ++ + LL+ A++ I KG PLH AA G+ E L+L
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585
Query: 103 KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVG 162
+ ++ + G PLH+AA + + V+ +LL ++P +G TPL +A + ++
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMD 645
Query: 163 VVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG 222
+ LL A +A G + +HLAA+ GH+D++ LLL ++N KSG
Sbjct: 646 IATTLLEYGADA--------NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSG 697
Query: 223 -TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
T LH AA + V +L++ G + + T L +
Sbjct: 698 LTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHV 736
Score = 103 bits (257), Expect = 1e-21
Identities = 68/246 (27%), Positives = 115/246 (46%), Gaps = 13/246 (5%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
+G S LH A + + LLL+ VD N + LH AA G + K++L +
Sbjct: 333 NGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKAN 392
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
N + G PLH+A + V E+LL+H ++ V SG TP+ +A G V +V L
Sbjct: 393 PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQL 452
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
+ + T+ G + LH+AA++G +++R L+Q G + + K T LH
Sbjct: 453 MHHGASP--------NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLH 504
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQV 286
+A GK ++V+ LL G + + T T L + + + ++ L + A+L +
Sbjct: 505 ISARLGKADIVQQLLQQGASPNAATTSGYTPLHL----SAREGHEDVAAFLLDHGASLSI 560
Query: 287 RATKDY 292
K +
Sbjct: 561 TTKKGF 566
Score = 98.2 bits (243), Expect = 5e-20
Identities = 71/240 (29%), Positives = 113/240 (47%), Gaps = 18/240 (7%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
+G++ LH AA ++ + LLE A + +G+ +H AA +G + + L+L +
Sbjct: 630 NGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNAN 689
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
VN+ + G PLHLAAQ +V+E+L+ ++ G TPL + C +G + +V L
Sbjct: 690 VNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFL 749
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
L + +A NG +PLH AA+ GH II +LLQ N T +G TAL
Sbjct: 750 LQHSAKV--------NAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALG 801
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQL----LREASA 282
A G VV L T + T + H+ + E+ + +R+A+A
Sbjct: 802 IARRLGYISVVDTL-----KIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANA 856
Score = 75.5 bits (184), Expect = 3e-13
Identities = 44/135 (32%), Positives = 67/135 (49%), Gaps = 2/135 (1%)
Query: 33 LLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQ 92
LLG + NVN + G + LH AA + +L+ A VD + G PLH
Sbjct: 683 LLG--RNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHY 740
Query: 93 GRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPL 152
G + + +L+ + VN + G+ PLH AAQ GH + +LLQ+ ++P + +G T L
Sbjct: 741 GNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800
Query: 153 DLACEFGRVGVVQLL 167
+A G + VV L
Sbjct: 801 GIARRLGYISVVDTL 815
Score = 73.2 bits (178), Expect = 2e-12
Identities = 68/259 (26%), Positives = 119/259 (45%), Gaps = 27/259 (10%)
Query: 48 DGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
D ++ AA G+ E ++ ++I + G+ LH A+ +G E + +L+ +
Sbjct: 40 DANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREAN 99
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
V+ + +G+ LH+A+ G +V ++L+ + +N +G TPL +A + + VV+ L
Sbjct: 100 VDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFL 159
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGT---A 224
L + +L AT+ +G +PL +A + GH ++ LLL+ TK A
Sbjct: 160 LDNGASQSL-------ATE-DGFTPLAVALQQGHDQVVSLLLE------NDTKGKVRLPA 205
Query: 225 LHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAAL 284
LH AA T+ LLL + NA V + T L I + + A+ L
Sbjct: 206 LHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGN----------INVATLLL 255
Query: 285 QVRATKDYCNNYDLTSLNV 303
A D+ D+T L+V
Sbjct: 256 NRAAAVDFTARNDITPLHV 274
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 855
Score = 116 bits (290), Expect = 2e-25
Identities = 171/670 (25%), Positives = 236/670 (35%), Gaps = 120/670 (17%)
Query: 825 QSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLN 884
++P R + P+P P +P P PP P A+ L +P +RA +
Sbjct: 15 RTPAARAPGLLTPRP------PGSPRPPPPVTPAALRVLGAAGAVGRKP--LAERAGGIG 66
Query: 885 RYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKG 944
+S P AGP R G S R PA R +
Sbjct: 67 GATIPESAPR---------AGP----TRSAGTSS--RNPASRPPASGRGERAPPAKNTSP 111
Query: 945 PPPPPPKRSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSI 1004
P P R+S L + + + E G + + S L+ ++G
Sbjct: 112 GPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGT 171
Query: 1005 A--AMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASVKH----------KEA 1052
AM S G RP P+ RP P G +V ++ +H +
Sbjct: 172 PSPAMARRSRAAGTEVGLPRPA---PSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRP 228
Query: 1053 IGPGGEVVNRRRTLSGPVTGLLATARRGPGESADPGPFVEDGTGRQRPRG---------- 1102
GG R+LS T L + AR GP SA P + +P+G
Sbjct: 229 SAGGGLQRPASRSLSSSATPLSSPARSGP--SARGTPRAPAHPSQPKPKGLQALRPPQVT 286
Query: 1103 -PSKGEAGVEGP----PLAKVEASATLKRR----IRAKQNQQENVKFILTESDTVKRRPK 1153
P K A GP PLA SA L+ + + A + + T P
Sbjct: 287 PPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPS 346
Query: 1154 A----KEREAGPEPPPPLSVYHNGTGTVRRR-------PASEQAGPPE-------LPP-- 1193
A + + P PP + G+ T++ P S A PP LPP
Sbjct: 347 APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQ 406
Query: 1194 --PPPPAEPPPTDLA------------HL-------PPLPPPEGEARKPAKPPVSPKPVL 1232
P PPA PP + LA HL PP PP + PA PPVSP
Sbjct: 407 APPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATP 466
Query: 1233 -TQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKP----PPPPTAP-----K 1282
+Q P L P P P SP PPP++ P PPP AP
Sbjct: 467 PSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATP 526
Query: 1283 PVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASP--AKPPSPGA-PALHVP 1339
P++A+ P+ G +P A P + LA PP P + A+P PPSP A P L P
Sbjct: 527 PLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAP 586
Query: 1340 AKPP-----RAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQE 1394
+PP + + A P PP S S+ + + ++A EE +R
Sbjct: 587 RRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEE-LRGY 645
Query: 1395 DAQGPRDSAA 1404
D+ GP AA
Sbjct: 646 DS-GPEGGAA 654
Score = 78.6 bits (192), Expect = 4e-14
Identities = 149/589 (25%), Positives = 204/589 (34%), Gaps = 141/589 (23%)
Query: 615 GGPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPT 674
GG L+R A +SL A P P+ +P+ LQA P +V P
Sbjct: 231 GGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR--PPQVTPP 288
Query: 675 TEKPSSHLPP---TPRATTRQDSSLGGRAR-------HMSSSQELLGD----GPPGPSSP 720
+ + L P +P AT ++L +A H SS L PP PS+P
Sbjct: 289 RKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAP 348
Query: 721 MSRSQEYLLDEGPAP-GTPPREARPGRHGHSIKRA------------SVPPVPGKPRQVL 767
S L P+P TPP +A +++ + PP P L
Sbjct: 349 PS------LQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALAL 402
Query: 768 PPGTSHFTPPQTPTKTRPGSPQALGGPHGP---------APATAKVKPTPQ--LLPPTER 816
PP + +PP +P P SP A P P AP + P Q PP
Sbjct: 403 PPLQAPPSPPASP----PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 458
Query: 817 PMSPRSLPQSPTHRGFA----YVLPQ-PVEGEVGPAA--PGPAPPPV-----------PT 858
P+SP + P S A V P P + P+A P APPP+ P
Sbjct: 459 PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQ 518
Query: 859 AVPTLCLPP------EADAEPGR-PKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQ 911
A P L PP + PG+ P + SL + P+ P A P V
Sbjct: 519 APPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAP----PVLAAPLLQVP 574
Query: 912 RRVGRSHSVRAP-----AGADKNVNRSQ-SFAVRPRKKGPPPPPPKRSSSALASANLADE 965
S +++AP G D +V+ + + A+ P GPPPPP + SS L+ +LA
Sbjct: 575 PSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAP---GPPPPPSRSPSSTLSGPDLAGH 631
Query: 966 PVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPE 1025
+ L G D+G GG AA PP+
Sbjct: 632 SSSATSTPEELRG--------------YDSGPE-----------------GGAAASPPPD 660
Query: 1026 G-----HPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRG 1080
HP P P + + A PG + T G GL
Sbjct: 661 AELAACHPAAWSRGPAP--------PLAFRGA--PGAPLPWPPATGPGSADGLCTIYETE 710
Query: 1081 PGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIR 1129
ESA P P D GPS G +G + A AS+ ++ R
Sbjct: 711 GPESATPAPGALD-------PGPSPGTSGGKAAAGAGAGASSRSPKQAR 752
Score = 71.6 bits (174), Expect = 5e-12
Identities = 147/632 (23%), Positives = 200/632 (31%), Gaps = 105/632 (16%)
Query: 634 PPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGP--TTEKPSSHLPPTPRATTR 691
P P P+PA + + + L +A P GP + S H P R
Sbjct: 167 PTPGTPSPAMARRSRAAGTEVG-LPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAAR 225
Query: 692 QDSSLGG-----RARHMSSSQELLGDG----------PPGPSSPMSRSQEYLLDEGPAPG 736
+ S GG +R +SSS L P P+ P + L P
Sbjct: 226 RRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQV 285
Query: 737 TPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGPHG 796
TPPR+ G P P Q P T TP + + +P L P
Sbjct: 286 TPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSP 345
Query: 797 PAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPV 856
AP + + P+P PP++ S S TH LP P P +P PPP
Sbjct: 346 SAPPSLQTLPSPPATPPSQATTSLGSPTLQATHS----FLPSP------PLSPLATPPP- 394
Query: 857 PTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGR 916
A P L LPP A P P + P L P+ P A
Sbjct: 395 -QAPPALALPP-LQAPPSPP--------------ASPPLSPLATPSPQAPNALAV----- 433
Query: 917 SHSVRAPAGADKNVNRSQSFAVRPRKKGPPPP---PPKRSSSALASANLADEPVPDAEPE 973
H ++AP + F+ P P P PP ++ +LA+ L P P A P
Sbjct: 434 -HLLQAPFSPPPSPPVQAPFS--PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPP 490
Query: 974 DGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPA 1033
++ S A L+L+ A P P P
Sbjct: 491 ---------------MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPP 535
Query: 1034 SPEPGRVA-TVLASVKHKEAIGPGGEV--VNRRRTL----SGPVTGLLATARRGPGESAD 1086
+ PG+ + AS+ P + V L S P + L RR P D
Sbjct: 536 ASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPD 595
Query: 1087 P---GPFVEDGTGRQRPRGPSKGEAG-VEGPPLAKVEASATLKRRIRAKQNQQENVKFIL 1142
GP + P PS+ + + GP LA +SAT
Sbjct: 596 TSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT------------------- 636
Query: 1143 TESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQA--GPPELPPPPPPAEP 1200
+ + ++ E A PPP + R PA A G P P P PPA
Sbjct: 637 STPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATG 696
Query: 1201 PPT--DLAHLPPLPPPEGEARKPAKPPVSPKP 1230
P + L + PE P P P
Sbjct: 697 PGSADGLCTIYETEGPESATPAPGALDPGPSP 728
Score = 70.1 bits (170), Expect = 1e-11
Identities = 188/833 (22%), Positives = 254/833 (30%), Gaps = 164/833 (19%)
Query: 666 TGPAEVGPTTEKPSSHLPPTP-RAT-TRQDSSLGGRARHMSSSQELL-GDGPPGPSSPMS 722
+G E P + S +P RA+ T + LG + +S+ + + G P
Sbjct: 97 SGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSAL 156
Query: 723 RSQEYLLDEGPAPGTP-PREARPGRHGHS---IKRASV-----PPVPGKPRQVLPPGTSH 773
+ GP PGTP P AR R + + R + PP G PR+ + + H
Sbjct: 157 SAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTEG-PRKSVSSASEH 215
Query: 774 FTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTH---- 829
T +P R P A GG PA + TP P P S R P++P H
Sbjct: 216 STTEPSPAARR--RPSAGGGLQRPASRSLSSSATPLSSPARSGP-SARGTPRAPAHPSQP 272
Query: 830 --RGFAYVLPQPVEGE-------VGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPK--- 877
+G + P V +GP + P P P+A PP A P
Sbjct: 273 KPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTC 332
Query: 878 KRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFA 937
+ A L S S P + L A P + +G + + SF
Sbjct: 333 QLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLG-----------SPTLQATHSFL 381
Query: 938 VRPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGS 997
P P PP ++ ALA L P P A P S LA T S
Sbjct: 382 PSP-PLSPLATPPPQAPPALALPPLQAPPSPPASPP------------LSPLA----TPS 424
Query: 998 AGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGG 1057
+ ++A L +A PP P P SP
Sbjct: 425 PQAPNALAVHLL--------QAPFSPPPSPPVQAPFSPPA-------------------- 456
Query: 1058 EVVNRRRTLSGPVTGLLATARRGPGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAK 1117
S PV+ + P A P V P PS PPLA
Sbjct: 457 ---------SPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAA 507
Query: 1118 VEASATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTV 1177
AK Q + P + +A P L + T
Sbjct: 508 PPLQL-------AKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPP 560
Query: 1178 RRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPA---------KPPVSP 1228
+ P P L PP P P PP P P+ P PP S
Sbjct: 561 QAPPV---LAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSR 617
Query: 1229 KPVLTQPVPKLQG-SPTPTSKKVPLPGPGS-PEVKRAHGTPP------------------ 1268
P T P L G S + TS L G S PE A PP
Sbjct: 618 SPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAAWSRGPAP 677
Query: 1269 -------PVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSL 1321
P +P P PP T P + + S P+P P G +
Sbjct: 678 PLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAAA 737
Query: 1322 GA-SPAKPPSPGAPAL--------------HVPAKPPRAAAA--AAAAAAAPPAPPEGAS 1364
GA + A SP L H+ ++ AAA AA + P EG
Sbjct: 738 GAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPGGAEGGG 797
Query: 1365 PGDSARQKLEETS----ACLAAALQAVEEKIRQEDAQGPRDSAAEKSTGSILD 1413
AR L + A L + L I + P D A+ + ++++
Sbjct: 798 VTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVASPQGDWTVVE 850
Score = 51.2 bits (121), Expect = 7e-06
Identities = 66/256 (25%), Positives = 88/256 (34%), Gaps = 28/256 (10%)
Query: 1175 GTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQ 1234
G R PA+ G PP P PPP A L L RKP L +
Sbjct: 11 GAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKP----------LAE 60
Query: 1235 PVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPK----PPPPPTAPKPVKAVAGL 1290
+ G+ P S P + R + PP S + PP T+P PV + G
Sbjct: 61 RAGGIGGATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSS-PGR 119
Query: 1291 PSGSAGPSPAPSPARQPPA--------ALAKPPGTPPSLGA-SPAKPPSPGAPALHVPAK 1341
SG+ P P + A A P + S GA P+PG P+ PA
Sbjct: 120 ASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS---PAM 176
Query: 1342 PPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGPRD 1401
R+ AA PAP P +K +SA + + R+ A G
Sbjct: 177 ARRSRAAGTEVGLPRPAPSARPRPPTEGPRK-SVSSASEHSTTEPSPAARRRPSAGGGLQ 235
Query: 1402 SAAEKSTGSILDDIGS 1417
A +S S + S
Sbjct: 236 RPASRSLSSSATPLSS 251
Score = 34.7 bits (78), Expect = 0.68
Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 15/192 (7%)
Query: 332 DRVGYFPSSLGEAIVKRAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAGGDRSGSI 391
D G P + A+ +R+ + AGTE LP+ + S+ P P E RK + +
Sbjct: 163 DTSGPTPGTPSPAMARRSRA-AGTEVGLPRPAPSARPRPPTEG---PRKSVSSASEHSTT 218
Query: 392 SGMAGGR---GSGGHALHAGSEGVKLLATVLSQKSVSESGPGDSPAKPPEGSAGVARSQP 448
R +GG S + AT LS S + SGP S P A ++ +P
Sbjct: 219 EPSPAARRRPSAGGGLQRPASRSLSSSATPLS--SPARSGP--SARGTPRAPAHPSQPKP 274
Query: 449 PVAHAGQVYGEQPPKK-LEPASEGKSSEAVSQWLTAFQLQLYAPNFISAGYDLPTISRMT 507
A + PP+K PA SS ++ + LQ AP + A P S +T
Sbjct: 275 KGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPA---TPHSSSLT 331
Query: 508 PEDLTAIGVTKP 519
+ T + + P
Sbjct: 332 CQLATPLPLAPP 343
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 115 bits (287), Expect = 4e-25
Identities = 104/356 (29%), Positives = 157/356 (44%), Gaps = 45/356 (12%)
Query: 39 KINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPM 98
+++V+ Q G++ L AA + +L +LLL A + D G PLH+AA G
Sbjct: 385 EVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTA 444
Query: 99 KLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEF 158
+L+L G+ V+ EG PLHLAAQ+ +V+ +L+ Q++P + + GKTPL +A F
Sbjct: 445 RLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYF 504
Query: 159 GRVGVVQLLLSS---------NMCAAL-LEPRPG---------------DATDPNGTSPL 193
G V +V+LL S N+ L L G DA D +G PL
Sbjct: 505 GHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPL 564
Query: 194 HLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNT 252
H AA G I ++LL+ G + T G T LH AA G E++ LL +S N
Sbjct: 565 HTAAARGKYLICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGA 624
Query: 253 YSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYCNNYDLTSLNVKAGDIITVL 312
+ T L + + + Q + +AA Q T + T L+V I +L
Sbjct: 625 VNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSV-----INLL 679
Query: 313 EQHPDGRWKGCIHDNRTGNDRVGYFPSSL----GEAIVKRAGSRAGTEPSLPQGSS 364
E H N ++VG+ P+ L G + + AG + + G S
Sbjct: 680 EHHA----------NVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVS 725
Score = 103 bits (258), Expect = 9e-22
Identities = 80/258 (31%), Positives = 125/258 (48%), Gaps = 14/258 (5%)
Query: 31 AKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAA 90
A+LL S ++ + N + +G + LH AA G+ L+ LL A +D + PLH A
Sbjct: 477 ARLLVS-RQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAV 535
Query: 91 WQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKT 150
+G+ ++ +LK+G+ + G+ PLH AA G Y + +MLL++ ++ + + G T
Sbjct: 536 ERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWT 595
Query: 151 PLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQ 210
PL LA G + ++ LL S+ A +PLHLAA++G ++ LLQ
Sbjct: 596 PLHLAAYKGHLEIIHLLAESHANMG--------ALGAVNWTPLHLAARHGEEAVVSALLQ 647
Query: 211 AGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQA 269
G D N +SG T LH A V LL+ N H RN T + +
Sbjct: 648 CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHL----AALKG 703
Query: 270 SREIKQLLREASAALQVR 287
+ I ++L EA A L V+
Sbjct: 704 NTAILKVLVEAGAQLDVQ 721
Score = 103 bits (257), Expect = 1e-21
Identities = 69/209 (33%), Positives = 110/209 (52%), Gaps = 9/209 (4%)
Query: 53 LHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPS 112
LH A G I LL++ A D D G PLH AA +G+ K++L+ G+++ +P+
Sbjct: 531 LHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPT 590
Query: 113 DEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNM 172
+G PLHLAA GH ++ +L + +N + TPL LA G VV LL
Sbjct: 591 HQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALL---Q 647
Query: 173 CAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALC 231
C A +P +A + +G +PLHLA + + LL+ +++ + K G T H AAL
Sbjct: 648 CGA--DP---NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALK 702
Query: 232 GKTEVVRLLLDSGINAHVRNTYSQTALDI 260
G T ++++L+++G V++ S T L +
Sbjct: 703 GNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
Score = 92.4 bits (228), Expect = 3e-18
Identities = 63/193 (32%), Positives = 94/193 (48%), Gaps = 9/193 (4%)
Query: 53 LHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPS 112
LH G+ E + LLL + VD + G PL AA + + L+L G+ N
Sbjct: 366 LHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVD 425
Query: 113 DEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNM 172
++G PLH AAQ+G + +LL H + + G TPL LA + V +LL+S
Sbjct: 426 EDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQA 485
Query: 173 CAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKS-GTALHEAALC 231
L E G +PLH+AA GH+ +++LL G +++ Q ++ T LH A
Sbjct: 486 DPNLHE--------AEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVER 537
Query: 232 GKTEVVRLLLDSG 244
GK ++ LL SG
Sbjct: 538 GKVRAIQHLLKSG 550
Score = 90.1 bits (222), Expect = 1e-17
Identities = 67/206 (32%), Positives = 96/206 (46%), Gaps = 13/206 (6%)
Query: 77 IKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQ 136
I +NK + PLH+ QG E ++L+L V+ + G+ PL +AAQ D+ +LL
Sbjct: 358 IYENK-VTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLA 416
Query: 137 HQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLA 196
H ++ VD G PL A + G G +LLL C DA + G +PLHLA
Sbjct: 417 HGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACV--------DAQEREGWTPLHLA 468
Query: 197 AKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQ 255
A+N ++ RLL+ D N G T LH AA G +V+LL G + +
Sbjct: 469 AQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLR 528
Query: 256 TALDIVHQFTTSQASREIKQLLREAS 281
T L H R I+ LL+ +
Sbjct: 529 TPL---HLAVERGKVRAIQHLLKSGA 551
Score = 48.5 bits (114), Expect = 5e-05
Identities = 34/128 (26%), Positives = 60/128 (46%)
Query: 50 FSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVN 109
++ LH AA +G ++S LL+ A + + G PLH A + + +L+ + V+
Sbjct: 627 WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH 686
Query: 110 IPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLS 169
+ G P HLAA G+ + ++L++ + + D TPL LA + G++ L
Sbjct: 687 ARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEG 746
Query: 170 SNMCAALL 177
A L
Sbjct: 747 KEPSVATL 754
Score = 40.4 bits (93), Expect = 0.012
Identities = 19/49 (38%), Positives = 31/49 (63%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYA 89
NV+ ++ G++ H AAL GNT ++ +L+EA A +D++D PL A
Sbjct: 684 NVHARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLA 732
Score = 39.7 bits (91), Expect = 0.021
Identities = 23/80 (28%), Positives = 39/80 (48%)
Query: 43 NFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102
N + G++ LH A + LLE A V ++ G P H AA +G +K+++
Sbjct: 653 NAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLV 712
Query: 103 KAGSAVNIPSDEGHIPLHLA 122
+AG+ +++ PL LA
Sbjct: 713 EAGAQLDVQDGVSCTPLQLA 732
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 115 bits (287), Expect = 4e-25
Identities = 94/308 (30%), Positives = 139/308 (45%), Gaps = 65/308 (21%)
Query: 4 EQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSA--LHHAALNGN 61
+++L++A KA DV T ++L +VN +D +G + LH AA
Sbjct: 493 DRQLLEAAKAGDVETVKKLCTVQ--------------SVNCRDIEGRQSTPLHFAAGYNR 538
Query: 62 TELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHL 121
++ LL+ A V KD G+ PLH A G E +L++K G+ VN+ PLH
Sbjct: 539 VSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHE 598
Query: 122 AAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL--------LSSNMC 173
AA G Y++ ++LLQH ++P + G TPLDL + G + LL + C
Sbjct: 599 AAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKD-GDTDIQDLLRGDAALLDAAKKGC 657
Query: 174 AA----LLEPRPGDATDPNG--TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG----- 222
A L P + D G ++PLHLAA ++++ LLQ G D+N Q K G
Sbjct: 658 LARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLH 717
Query: 223 -----------------------------TALHEAALCGKTEVVRLLLDSGINAHVRNTY 253
T LHEAA G+T++ LLL G + ++N
Sbjct: 718 NAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQE 777
Query: 254 SQTALDIV 261
QT LD+V
Sbjct: 778 GQTPLDLV 785
Score = 102 bits (254), Expect = 3e-21
Identities = 82/257 (31%), Positives = 126/257 (49%), Gaps = 17/257 (6%)
Query: 19 AQRLLQRPRPG---KAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAV 75
A+ L + R G + K L + +K+N + LH AA G +++ LL+ A V
Sbjct: 25 ARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV 84
Query: 76 DIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLL 135
+D+ G+ PLH A G E + L+L+ G+ N + + PLH AA G DV +LL
Sbjct: 85 QARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLL 144
Query: 136 QHQSNPCMVDNSGKTPLDLA---------CEFGRVGVVQLLLSSN--MCAALLEPRPGD- 183
QH + P + + G+T LDLA E+ + +++ S N ALL P +
Sbjct: 145 QHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNC 204
Query: 184 -ATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLL 241
A+D ++PLHLAA + I++LLLQ G D++ + K LH A G EV LL+
Sbjct: 205 HASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLV 264
Query: 242 DSGINAHVRNTYSQTAL 258
G + + + T L
Sbjct: 265 KHGACVNAMDLWQFTPL 281
Score = 93.6 bits (231), Expect = 1e-18
Identities = 82/284 (28%), Positives = 123/284 (43%), Gaps = 43/284 (15%)
Query: 38 KKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEP 97
K N+N + + + LH A+ + +++ ++++ +A V+ DN G LH AA+ G +
Sbjct: 389 KGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQT 448
Query: 98 MKLVLKAGSAVNIPSDEGHIPLHL--------------------------AAQHGHYDVS 131
+L+L G NI S +G L + AA+ G +
Sbjct: 449 CRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETV 508
Query: 132 EMLLQHQSNPCM-VDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGT 190
+ L QS C ++ TPL A + RV VV+ LL A D G
Sbjct: 509 KKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADV--------HAKDKGGL 560
Query: 191 SPLHLAAKNGHIDIIRLLLQAGIDIN-RQTKSGTALHEAALCGKTEVVRLLLDSGINAHV 249
PLH A GH ++ LL++ G +N T LHEAA GK E+ +LLL G +
Sbjct: 561 VPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTK 620
Query: 250 RNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDYC 293
+N T LD+V T +I+ LLR +A L A K C
Sbjct: 621 KNRDGNTPLDLVKDGDT-----DIQDLLRGDAALLD--AAKKGC 657
Score = 73.9 bits (180), Expect = 1e-12
Identities = 50/134 (37%), Positives = 68/134 (50%), Gaps = 11/134 (8%)
Query: 145 DNSGK--TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHI 202
D +G+ TPL A FGR VV+ LL + A D G PLH A GH
Sbjct: 53 DTAGRKSTPLHFAAGFGRKDVVEYLLQNGANV--------QARDDGGLIPLHNACSFGHA 104
Query: 203 DIIRLLLQAGIDIN-RQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIV 261
+++ LLL+ G D N R + T LHEAA+ GK +V +LL G +RNT +TALD+
Sbjct: 105 EVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLA 164
Query: 262 HQFTTSQASREIKQ 275
+ + E K+
Sbjct: 165 DPSAKAVLTGEYKK 178
Score = 71.6 bits (174), Expect = 5e-12
Identities = 92/355 (25%), Positives = 131/355 (36%), Gaps = 102/355 (28%)
Query: 30 KAKLLGSTKKINVNFQDPDGFSALHHAALNGNTE-LISLLLEAQAAVDIKDNKGMRPLHY 88
KA L G KK L +A +GN E +++LL D + PLH
Sbjct: 169 KAVLTGEYKK-----------DELLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHL 217
Query: 89 AAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSG 148
AA R + ++L+L+ G+ V+ +PLH A +GHY+V+E+L++H + +D
Sbjct: 218 AAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQ 277
Query: 149 KTPLDLACEFGRVGVVQLLLS----------SNMCAALLEPRP----------------- 181
TPL A RV V LLLS N A L P P
Sbjct: 278 FTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQ 337
Query: 182 ----GDAT---------------DPNGTSPLHLAAKNGH---IDIIRLLLQAGIDINRQT 219
D T + LH AA + + I LLL+ G +IN +T
Sbjct: 338 AAREADVTRIKKHLSLEMVNFKHPQTHETALHCAAASPYPKRKQICELLLRKGANINEKT 397
Query: 220 K----------------------------------SGTALHEAALCGKTEVVRLLLDSGI 245
K T+LH AA CG + RLLL G
Sbjct: 398 KEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGC 457
Query: 246 NAHVRNTYSQTALDI-------VHQFTTSQASREIKQLLREASAALQVRATKDYC 293
+ ++ + TAL + + Q S + E + L EA+ A V K C
Sbjct: 458 DPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLC 512
Score = 58.5 bits (140), Expect = 4e-08
Identities = 51/165 (30%), Positives = 76/165 (46%), Gaps = 14/165 (8%)
Query: 49 GFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMR--PLHYAAWQGRKEPMKLVLKAGS 106
G +AL AA G + L + V+ +D +G PLH AA E + +L+ G+
Sbjct: 645 GDAALLDAAKKGCLARVKKL-SSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGA 703
Query: 107 AVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQL 166
VN G IPLH AA +GH DV+ +L+++ + D TPL A + GR + L
Sbjct: 704 DVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCAL 763
Query: 167 LLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQA 211
LL+ L + G +PL L + + D+ LL A
Sbjct: 764 LLAHGADPTL--------KNQEGQTPLDLVSAD---DVSALLTAA 797
Score = 57.0 bits (136), Expect = 1e-07
Identities = 34/94 (36%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
+VN QD G LH+AA G+ ++ +LL++ A V+ D PLH AA +GR + L
Sbjct: 704 DVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCAL 763
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEML 134
+L G+ + + EG PL L + DVS +L
Sbjct: 764 LLAHGADPTLKNQEGQTPLDLVSAD---DVSALL 794
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 114 bits (286), Expect = 5e-25
Identities = 176/677 (25%), Positives = 223/677 (32%), Gaps = 126/677 (18%)
Query: 778 QTPTKTRPG--SPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYV 835
+TP PG +P+ G P P P T P + R L + V
Sbjct: 15 RTPAARAPGLLTPRPPGSPRPPPPVT---------------PAALRVLGAAGA------V 53
Query: 836 LPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPER 895
+P+ G P P A PT P A GR ++ + N S P R
Sbjct: 54 GRKPLAERAGGIGGATIPESAPRAGPTRTSRPPAS---GRGERAPPAKNTSPGPVSSPGR 110
Query: 896 DELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPK---- 951
GP R+ +V + + S R GP P P
Sbjct: 111 AS--GTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMA 168
Query: 952 RSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELS 1011
R S A + P P A P G R KS+++ E S
Sbjct: 169 RRSRAAGTEVGLPRPAPSARPRPPTEGPR---------------------KSVSSASEHS 207
Query: 1012 SIGGGGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVT 1071
+ A RRP G RPAS AT L+S SGP
Sbjct: 208 TTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPAR-----------------SGP-- 248
Query: 1072 GLLATARRGPGESADPGPFVEDGTGRQRP---RGPSKGEAGVEGP----PLAKVEASATL 1124
+AR P A P G RP P K A GP PLA SA
Sbjct: 249 ----SARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPP 304
Query: 1125 KRRIRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASE 1184
+ T + P PPLS T + PA
Sbjct: 305 SPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPL--ATPPPQAPPAL- 361
Query: 1185 QAGPPELPPPPPPAEPPPTDLA------------HL-------PPLPPPEGEARKPAKPP 1225
A PP PP PPA PP + LA HL PP PP + PA PP
Sbjct: 362 -ALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 420
Query: 1226 VSPKPVL-TQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKP----PPPPTA 1280
VSP +Q P L P P P SP PPP++ P PPP A
Sbjct: 421 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQA 480
Query: 1281 P-----KPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASP--AKPPSPGA 1333
P P++A+ P+ G +P A P + LA PP P + A+P PPSP A
Sbjct: 481 PPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPA 540
Query: 1334 -PALHVPAKPP-----RAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAV 1387
P L P +PP + + A P PP S S+ + + ++A
Sbjct: 541 SPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTP 600
Query: 1388 EEKIRQEDAQGPRDSAA 1404
EE +R D+ GP AA
Sbjct: 601 EE-LRGYDS-GPEGGAA 615
Score = 74.3 bits (181), Expect = 8e-13
Identities = 141/574 (24%), Positives = 191/574 (33%), Gaps = 141/574 (24%)
Query: 615 GGPLRRKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPT 674
GG L+R A +SL A P P+ +P+ LQA P +V P
Sbjct: 222 GGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALR--PPQVTPP 279
Query: 675 TEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPA 734
+ + L P SS L P P SP + L PA
Sbjct: 280 RKDAAPALGPL-------------------SSSPLATPSPSAPPSPSAPPSLQTLPSPPA 320
Query: 735 PGTPPREARPGRHGHSIKRA------------SVPPVPGKPRQVLPPGTSHFTPPQTPTK 782
TPP +A +++ + PP P LPP + +PP +P
Sbjct: 321 --TPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASP-- 376
Query: 783 TRPGSPQALGGPHGP---------APATAKVKPTPQ--LLPPTERPMSPRSLPQSPTHRG 831
P SP A P P AP + P Q PP P+SP + P S
Sbjct: 377 --PLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPS 434
Query: 832 FA----YVLPQ-PVEGEVGPAA--PGPAPPPV-----------PTAVPTLCLPP------ 867
A V P P + P+A P APPP+ P A P L PP
Sbjct: 435 LAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPS 494
Query: 868 EADAEPGR-PKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAP--- 923
+ PG+ P + SL + P+ P A P V S +++AP
Sbjct: 495 PPASFPGQAPFSPSASLPMSPLATPPPQAP----PVLAAPLLQVPPSPPASPTLQAPRRP 550
Query: 924 --AGADKNVNRSQ-SFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGLLGVR 980
G D +V+ + + A+ P GPPPPP + SS L+ +LA + L G
Sbjct: 551 PTPGPDTSVSGPRLTLALAP---GPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRG-- 605
Query: 981 AQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEG-----HPTPRPASP 1035
D+G GG AA PP+ HP P
Sbjct: 606 ------------YDSGPE-----------------GGAAASPPPDAELAACHPAAWSRGP 636
Query: 1036 EPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPGESADPGPFVEDGT 1095
P + + A PG + T G GL ESA P P D
Sbjct: 637 AP--------PLAFRGA--PGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALD-- 684
Query: 1096 GRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIR 1129
GPS G +G + A AS+ ++ R
Sbjct: 685 -----PGPSPGTSGGKAAAGAGAGASSRSPKQAR 713
Score = 70.5 bits (171), Expect = 1e-11
Identities = 149/624 (23%), Positives = 203/624 (32%), Gaps = 119/624 (19%)
Query: 634 PPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGP--TTEKPSSHLPPTPRATTR 691
P P P+PA + + + L +A P GP + S H P R
Sbjct: 158 PTPGTPSPAMARRSRAAGTEVG-LPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAAR 216
Query: 692 QDSSLGG-----RARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARPGR 746
+ S GG +R +SSS L P S P +R GTP A P +
Sbjct: 217 RRPSAGGGLQRPASRSLSSSATPLSS--PARSGPSAR------------GTPRAPAHPSQ 262
Query: 747 HGHSIKRASVPPVPGKPRQVLPP--GTSHFTPPQTPTKTRPGSPQALGGPHGPAPATAKV 804
+A PP PR+ P G +P TP+ + P SP A P + +
Sbjct: 263 PKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSA--------PPSLQT 314
Query: 805 KPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLC 864
P+P PP++ S S TH LP P P +P PPP A P L
Sbjct: 315 LPSPPATPPSQATTSLGSPTLQATHS----FLPSP------PLSPLATPPP--QAPPALA 362
Query: 865 LPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPA 924
LPP A P P + P L P+ P A H ++AP
Sbjct: 363 LPP-LQAPPSPP--------------ASPPLSPLATPSPQAPNALAV------HLLQAPF 401
Query: 925 GADKNVNRSQSFAVRPRKKGPPPP---PPKRSSSALASANLADEPVPDAEPEDGLLGVRA 981
+ F+ P P P PP ++ +LA+ L P P A P
Sbjct: 402 SPPPSPPVQAPFS--PPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPP-------- 451
Query: 982 QCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRVA 1041
++ S A L+L+ A P P P + PG+
Sbjct: 452 -------MSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAP 504
Query: 1042 -TVLASVKHKEAIGPGGEV--VNRRRTL----SGPVTGLLATARRGPGESADP---GPFV 1091
+ AS+ P + V L S P + L RR P D GP +
Sbjct: 505 FSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRL 564
Query: 1092 EDGTGRQRPRGPSKGEAG-VEGPPLAKVEASATLKRRIRAKQNQQENVKFILTESDTVKR 1150
P PS+ + + GP LA +SAT + + ++
Sbjct: 565 TLALAPGPPPPPSRSPSSTLSGPDLAGHSSSAT-------------------STPEELRG 605
Query: 1151 RPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQA--GPPELPPPPPPAEPPPT--DLA 1206
E A PPP + R PA A G P P P PPA P + L
Sbjct: 606 YDSGPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLC 665
Query: 1207 HLPPLPPPEGEARKPAKPPVSPKP 1230
+ PE P P P
Sbjct: 666 TIYETEGPESATPAPGALDPGPSP 689
Score = 66.2 bits (160), Expect = 2e-10
Identities = 194/842 (23%), Positives = 260/842 (30%), Gaps = 153/842 (18%)
Query: 691 RQDSSLGGRARHMSSSQE--LLGDGPPG---PSSPMSRSQEYLLDEGPAPGTPPREARPG 745
++D + G A +++ LL PPG P P++ + +L A G P R G
Sbjct: 4 KRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAG 63
Query: 746 RHGHSIKRASVPPVPGKPRQVLPP--GTSHFTPPQTPTKTRP-GSPQALGGPHGPAPATA 802
G + S P G R PP G PP T P SP G P P
Sbjct: 64 GIGGATIPESAPRA-GPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQ 122
Query: 803 K-----VKPTPQLLPPTERPMSPRSLPQSPTHR---GFAYVLPQPVEGEVGPAA------ 848
K + T TE P RS + R G P P AA
Sbjct: 123 KGLRISAEETVARGKATEAPK--RSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGL 180
Query: 849 PGPAP---PPVPTAVPTLCLPPEAD---AEPGRPKKRAHS----LNRYAASDSEPERDEL 898
P PAP P PT P + ++ EP +R S L R A+ L
Sbjct: 181 PRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPL 240
Query: 899 LVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALA 958
PA +GP A R S P G + + V P +K P SSS LA
Sbjct: 241 SSPARSGPSARGTPRAPAHPSQPKPKG----LQALRPPQVTPPRKDAAPALGPLSSSPLA 296
Query: 959 SANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGG--- 1015
+ + + P P A P L S S+ + + + S LS +
Sbjct: 297 TPSPSAPPSPSAPPSLQTLP-SPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPP 355
Query: 1016 -GGRAARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLL 1074
A PP P PASP +AT + A+ LL
Sbjct: 356 QAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVH------------------LL 397
Query: 1075 ATARRGPGESADPGPFVEDGTGRQRPRG--PSKGEAGVEGPPL-AKVEASATLKRRIRAK 1131
P PF + P PS+ + PPL A+ A
Sbjct: 398 QAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSAT 457
Query: 1132 QNQQENVKFILTESDTVKRRPKAKEREAGPE----PPPPLSVYHNGTGTVRRRPASEQAG 1187
Q K P+A A P P PP S + P S A
Sbjct: 458 PPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASF-------PGQAPFSPSAS 510
Query: 1188 PPELPPPPPPAEPPPT---DLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQ---- 1240
P P PP + PP L +PP PP + P +PP +P P + P+L
Sbjct: 511 LPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPP-TPGPDTSVSGPRLTLALA 569
Query: 1241 -GSPTPTSKKVP--LPGP--------------------GSPEVKRAHGTPP--------- 1268
G P P S+ L GP PE A PP
Sbjct: 570 PGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHP 629
Query: 1269 ----------------PVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALA 1312
P +P P PP T P + + S P+P P
Sbjct: 630 AAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSP 689
Query: 1313 KPPGTPPSLGA-SPAKPPSPGAPAL--------------HVPAKPPRAAAA--AAAAAAA 1355
G + GA + A SP L H+ ++ AAA AA +
Sbjct: 690 GTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGG 749
Query: 1356 PPAPPEGASPGDSARQKLEETS----ACLAAALQAVEEKIRQEDAQGPRDSAAEKSTGSI 1411
P EG AR L + A L + L I + P D A+ + ++
Sbjct: 750 GPGGAEGGGVTGGARAALSDAELGRWAELLSPLDESRASITSVTSFSPDDVASPQGDWTV 809
Query: 1412 LD 1413
++
Sbjct: 810 VE 811
Score = 51.2 bits (121), Expect = 7e-06
Identities = 67/252 (26%), Positives = 86/252 (34%), Gaps = 29/252 (11%)
Query: 1175 GTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQ 1234
G R PA+ G PP P PPP A L L RKP T
Sbjct: 11 GAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATI 70
Query: 1235 PVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGS 1294
P + PT TS+ P S +RA PP T+P PV + G SG+
Sbjct: 71 PESAPRAGPTRTSRP-----PASGRGERA----------PPAKNTSPGPVSS-PGRASGT 114
Query: 1295 AGPSPAPSPARQPPA--------ALAKPPGTPPSLGA-SPAKPPSPGAPALHVPAKPPRA 1345
P P + A A P + S GA P+PG P+ PA R+
Sbjct: 115 TRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS---PAMARRS 171
Query: 1346 AAAAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGPRDSAAE 1405
AA PAP P +K +SA + + R+ A G A
Sbjct: 172 RAAGTEVGLPRPAPSARPRPPTEGPRK-SVSSASEHSTTEPSPAARRRPSAGGGLQRPAS 230
Query: 1406 KSTGSILDDIGS 1417
+S S + S
Sbjct: 231 RSLSSSATPLSS 242
Score = 31.2 bits (69), Expect = 7.5
Identities = 37/136 (27%), Positives = 55/136 (40%), Gaps = 11/136 (8%)
Query: 332 DRVGYFPSSLGEAIVKRAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAGGDRSGSI 391
D G P + A+ +R+ + AGTE LP+ + S+ P P E RK + +
Sbjct: 154 DTSGPTPGTPSPAMARRSRA-AGTEVGLPRPAPSARPRPPTEG---PRKSVSSASEHSTT 209
Query: 392 SGMAGGR---GSGGHALHAGSEGVKLLATVLSQKSVSESGPGDSPAKPPEGSAGVARSQP 448
R +GG S + AT LS S + SGP S P A ++ +P
Sbjct: 210 EPSPAARRRPSAGGGLQRPASRSLSSSATPLS--SPARSGP--SARGTPRAPAHPSQPKP 265
Query: 449 PVAHAGQVYGEQPPKK 464
A + PP+K
Sbjct: 266 KGLQALRPPQVTPPRK 281
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 114 bits (285), Expect = 7e-25
Identities = 74/212 (34%), Positives = 109/212 (51%), Gaps = 10/212 (4%)
Query: 49 GFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEP-MKLVLKAGSA 107
G +ALH A NG +++ L++ A V+ +N G PLH+AA ++L++ G+
Sbjct: 214 GNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGAD 273
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL 167
VNI S +G PLH+ A HG + S+ L+Q+ VD G TPL +A +G ++ L
Sbjct: 274 VNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTL 333
Query: 168 LSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALH 226
+S A + PLHLAA N H D R LL +G +I+ K G T LH
Sbjct: 334 RTSGADTA--------KCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLH 385
Query: 227 EAALCGKTEVVRLLLDSGINAHVRNTYSQTAL 258
AA G E ++LL SG + H ++ +T L
Sbjct: 386 AAAAGGNVECIKLLQSSGADFHKKDKCGRTPL 417
Score = 109 bits (272), Expect = 2e-23
Identities = 75/224 (33%), Positives = 114/224 (50%), Gaps = 9/224 (4%)
Query: 38 KKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEP 97
K +VN D + + LH AA G+ E+I LL+ + A V+ KDN + PLH A +E
Sbjct: 5 KTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEA 64
Query: 98 MKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACE 157
+++++K + VN PLH+AA + +E+++ S+ + D G+T L A
Sbjct: 65 VQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAAL 124
Query: 158 FGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINR 217
G V +V LLL+ +A D LH AA GH+D++ LL+ G ++
Sbjct: 125 NGHVEMVNLLLAKGANI--------NAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176
Query: 218 QTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
+ K G T LH AA G+ VV+ LL+ G+ N Y TAL I
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHI 220
Score = 109 bits (272), Expect = 2e-23
Identities = 72/206 (34%), Positives = 113/206 (54%), Gaps = 10/206 (4%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
+VN D G +ALHHAALNG+ E+++LLL A ++ D K R LH+AA+ G + + L
Sbjct: 107 SVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVAL 166
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
++ G+ V +G+ PLH AA +G +V + LL ++ G T L +AC G+
Sbjct: 167 LINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQ 226
Query: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDI-IRLLLQAGIDINRQT 219
VV L+ A + +P + NG +PLH AA + H + + LL+ G D+N Q+
Sbjct: 227 DAVVNELIDYG--ANVNQP------NNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Query: 220 KSG-TALHEAALCGKTEVVRLLLDSG 244
K G + LH A+ G+ + L+ +G
Sbjct: 279 KDGKSPLHMTAVHGRFTRSQTLIQNG 304
Score = 96.3 bits (238), Expect = 2e-19
Identities = 82/282 (29%), Positives = 124/282 (43%), Gaps = 60/282 (21%)
Query: 37 TKKINVNFQDPDGFSALHHAALN---------GN-------------------TELISLL 68
T NVN D G +ALH+AA + GN T + L
Sbjct: 434 TTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFL 493
Query: 69 LEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEG--HIPLHLAAQHG 126
L+ A I+D +G +HYAA G ++ ++L+L+ ++ SD G PLHLAA +G
Sbjct: 494 LQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNG 553
Query: 127 HYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLS----------------- 169
H+ E+LLQ + + D G+T LDLA G V+ L++
Sbjct: 554 HHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPL 613
Query: 170 -------SNMCAALL-----EPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINR 217
+C LL P D D G +PL LA GHID + LLL+ +++
Sbjct: 614 HASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDT 673
Query: 218 QTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTAL 258
G TALH + G E V++LL+ ++ +++ +T L
Sbjct: 674 VDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPL 715
Score = 95.1 bits (235), Expect = 4e-19
Identities = 68/233 (29%), Positives = 118/233 (50%), Gaps = 13/233 (5%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
+VN +D + + LH AA N + +++ ++V++ D G LH+AA G E + L
Sbjct: 74 DVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNL 133
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
+L G+ +N + LH AA GH DV +L+ H + D G TPL A G+
Sbjct: 134 LLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQ 193
Query: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTK 220
+ VV+ LL+ + D + G + LH+A NG ++ L+ G ++N+
Sbjct: 194 INVVKHLLNLGV--------EIDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNN 245
Query: 221 SG-TALHEAALCGKTEV-VRLLLDSGINAHVRNTYSQTALDI--VH-QFTTSQ 268
+G T LH AA + + LL+++G + ++++ ++ L + VH +FT SQ
Sbjct: 246 NGFTPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQ 298
Score = 87.8 bits (216), Expect = 7e-17
Identities = 63/217 (29%), Positives = 106/217 (48%), Gaps = 16/217 (7%)
Query: 38 KKINVNFQDPDGF---SALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGR 94
++ N F++ D S LH AA NG+ + + +LL++ +DI+D KG L AA++G
Sbjct: 528 ERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGH 587
Query: 95 KEPMKLVLKAGSAVNIPSD-EGHIPLHLAAQHGHYDVSEMLLQHQSNPCMV---DNSGKT 150
E ++ ++ G+++ + + PLH + +GH +LL+ NP V D G+T
Sbjct: 588 TECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQT 647
Query: 151 PLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQ 210
PL LA +G + V LLL D D G + LH GH + +++LL+
Sbjct: 648 PLMLAVAYGHIDAVSLLLEKEANV--------DTVDILGCTALHRGIMTGHEECVQMLLE 699
Query: 211 AGIDI-NRQTKSGTALHEAALCGKTEVVRLLLDSGIN 246
+ I + ++ T LH AA G + LL ++
Sbjct: 700 QEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALS 736
Score = 87.8 bits (216), Expect = 7e-17
Identities = 70/232 (30%), Positives = 103/232 (44%), Gaps = 30/232 (12%)
Query: 42 VNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLV 101
V+ +D G + L A G+ + +SLLLE +A VD D G LH G +E ++++
Sbjct: 638 VDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQML 697
Query: 102 LKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQ---HQSNPCMVDNSGKTPLDLACEF 158
L+ ++ G PLH AA GH LLQ + + C DN G TPL AC
Sbjct: 698 LEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYN 757
Query: 159 GRVGVVQLLLSSNM----------------------CAALL----EPRPGDATDPNGTSP 192
G +++LL CA+LL + D G +P
Sbjct: 758 GNENCIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTP 817
Query: 193 LHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDS 243
L AA H++ ++LLL+ +N SG TAL AA G+ V +L++S
Sbjct: 818 LRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS 869
Score = 82.8 bits (203), Expect = 2e-15
Identities = 62/214 (28%), Positives = 103/214 (48%), Gaps = 16/214 (7%)
Query: 67 LLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHG 126
+L+ V+ D++ PLH AA+ G E ++L++ +G+ VN + PLH A
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 127 HYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEP--RPGDA 184
+ ++L++H ++ D + +TPL +A V CA ++ P +
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAV----------KCAEVIIPLLSSVNV 110
Query: 185 TDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINR-QTKSGTALHEAALCGKTEVVRLLLDS 243
+D G + LH AA NGH++++ LLL G +IN K ALH AA G +VV LL++
Sbjct: 111 SDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Query: 244 GINAHVRNTYSQTALDIVHQFTTSQASREIKQLL 277
G ++ T L H ++ +K LL
Sbjct: 171 GAEVTCKDKKGYTPL---HAAASNGQINVVKHLL 201
Score = 82.8 bits (203), Expect = 2e-15
Identities = 58/168 (34%), Positives = 81/168 (48%), Gaps = 10/168 (5%)
Query: 44 FQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLK 103
F+D G++ LH A NGN I +LLE + N PLH A L+L
Sbjct: 742 FKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP-FTPLHCAIINDHGNCASLLLG 800
Query: 104 A--GSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRV 161
A S V+ D+G PL AA H + ++LL+H + VDNSGKT L +A E G+
Sbjct: 801 AIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQA 860
Query: 162 GVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209
G V +L++S ++ D + +PLHLA GH L+L
Sbjct: 861 GAVDILVNSAQADLTVK-------DKDLNTPLHLACSKGHEKCALLIL 901
Score = 80.9 bits (198), Expect = 8e-15
Identities = 62/190 (32%), Positives = 81/190 (42%), Gaps = 9/190 (4%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
+VN Q DG S LH A++G L++ +D D G PLH AA G + +
Sbjct: 273 DVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINT 332
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
+ +G+ PLHLAA + H D LL D G+T L A G
Sbjct: 333 LRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGN 392
Query: 161 VGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTK 220
V ++LL SS D G +PLH AA N H I L+ G ++N
Sbjct: 393 VECIKLLQSSG--------ADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDD 444
Query: 221 SG-TALHEAA 229
G TALH AA
Sbjct: 445 WGRTALHYAA 454
Score = 73.6 bits (179), Expect = 1e-12
Identities = 70/234 (29%), Positives = 107/234 (45%), Gaps = 22/234 (9%)
Query: 32 KLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAW 91
KLL S +I+ D G + LH AA GN E I LL + A KD G PLHYAA
Sbjct: 365 KLLSSGFEIDT--PDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAA 422
Query: 92 QGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTP 151
++ ++ G+ VN D G LH AA D ++ +L + DNS +
Sbjct: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAA-SDMDRNKTILGNAH-----DNSEE-- 474
Query: 152 LDLACEFGRVGVVQLLLSSNMCAALLEPRPGDAT--DPNGTSPLHLAAKNGHIDIIRLLL 209
L+ A E + +C L + + D G + +H AA GH + LLL
Sbjct: 475 LERARELKEK-------EATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLL 527
Query: 210 Q---AGIDINRQTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
+ +G + + + + LH AA G + + +LL S ++ +R+ +TALD+
Sbjct: 528 ERTNSGFEESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDL 581
Score = 58.9 bits (141), Expect = 3e-08
Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 3/134 (2%)
Query: 50 FSALHHAALNGNTELISLLLEA--QAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSA 107
F+ LH A +N + SLLL A + V +D+KG PL AA+ E ++L+L+ +
Sbjct: 780 FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAP 839
Query: 108 VNIPSDEGHIPLHLAAQHGHYDVSEMLLQH-QSNPCMVDNSGKTPLDLACEFGRVGVVQL 166
VN + G L +AA++G ++L+ Q++ + D TPL LAC G L
Sbjct: 840 VNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALL 899
Query: 167 LLSSNMCAALLEPR 180
+L +L+ +
Sbjct: 900 ILDKIQDESLINEK 913
Score = 47.8 bits (112), Expect = 8e-05
Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 1/114 (0%)
Query: 33 LLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQ 92
LLG+ V+ +D G + L AA + E + LLL A V+ DN G L AA
Sbjct: 798 LLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAEN 857
Query: 93 GRKEPMKLVLKAGSA-VNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVD 145
G+ + +++ + A + + + + PLHLA GH + ++L + +++
Sbjct: 858 GQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLIN 911
>gi|153792074 proline rich 12 [Homo sapiens]
Length = 2036
Score = 113 bits (283), Expect = 1e-24
Identities = 209/795 (26%), Positives = 282/795 (35%), Gaps = 136/795 (17%)
Query: 667 GPAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQE 726
GPA +GP P PP P R H+ + LL ++ S +
Sbjct: 215 GPAGLGPAQTPPYRPGPPDPPPPPR----------HLPTQFNLLASSSAAAAAAEQSSPQ 264
Query: 727 YLLDEGPAPGTPPREARPGRHGHSIKR-----ASVPPVPGKPRQVLPP----GTSHFTPP 777
G APG PP E R IK ++ PP P P L G S+ P
Sbjct: 265 LYNFSGAAPGPPPPERALPRQDTVIKHYQRPASAQPPPPPPPAHALQHYLSCGGSY--PS 322
Query: 778 QTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRG---FAY 834
SP G P A +K P+ + R P + G +
Sbjct: 323 MGHRANLACSPLGGGEPSPGAGEPSKAGPSGATAGASGRATGPEAAGGGGAGGGGGGYRP 382
Query: 835 VLPQPV----EGEVGPAAPGPAPPPVP--TAVPTL-CLPPEADAEPGRPKKRAHSLNRYA 887
++ P +G G AA G PP P TA P L A A A A
Sbjct: 383 IIQSPGYKTGKGGYGAAAGGATRPPPPRSTATPKCQSLGGPAAAYATGKASGAGGAGGQA 442
Query: 888 ASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPP 947
S +P+ GP A Q G G ++++++ S++ P + P
Sbjct: 443 YSPGQPQ-------GLLGPQAYGQGFGG---------GQAQDLSKAPSYSGGPPQPPSGP 486
Query: 948 PPPKRSSSALASANLADEPV--PDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIA 1005
PPP ++ S + + EP G +Q + + S TG + ++
Sbjct: 487 PPPGLATCQSYSPDQLQGQLYGVQGEPYPGP-AAHSQGLPTASPSLSYSTGHSPALSGHG 545
Query: 1006 AMLELSSIGGGGRAA--------RRPPEGHPTPRPASP-EPGR-VATVLASVKH------ 1049
SS+GGGG A+ + PP P SP PG+ +++VLAS
Sbjct: 546 GGWGPSSLGGGGEASPSHIIRPLQSPPATGRPPGVGSPGAPGKYLSSVLASAPFLAPPGA 605
Query: 1050 -----------------KEAIGPGGEVVNRRRTLSGPVTGLLATARRGPGESADPGPFVE 1092
+ GPGG R + LL A P S G E
Sbjct: 606 GSYAAGAGGYKGKGDGSELLAGPGGPPAERTEDEEFLIQHLLQ-APSPPRTSGADGLVGE 664
Query: 1093 DGTG-RQRPRGPSKGEAGVEGPP--LAKVEASAT-LKRRIRAKQNQQENVKFILTESDTV 1148
DG + G S G G G P LAK + L+ IR + E L E
Sbjct: 665 DGAADASKGLGGSGGAGGPPGTPYELAKEDPQRYHLQSVIRTSASLDEGATAAL-ELGLG 723
Query: 1149 KRRPKAKEREAGPEPPPPL--SVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLA 1206
+ + K K E G E P L SV H G G + A Q PP PPPP A+
Sbjct: 724 RLKEKKKGPERGGETPEGLATSVVHYGAGA-KELGAFLQKSPP---PPPPTAQSTQ---- 775
Query: 1207 HLPPLPPPEG---EARKPAKPPV--SPKPVLTQPVPKLQGSPTPTSKKV------PLPGP 1255
P P G EA P P V P P L V SP+P++ KV P
Sbjct: 776 -----PTPHGLLLEAGGPDLPLVLPPPPPQLLPSVLSHAPSPSPSASKVGVHLLEPATRD 830
Query: 1256 GSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPP 1315
G+P+ PPP P PP P P++ A L S P+ APSP +P +L P
Sbjct: 831 GAPQ------PPPPPPPPPP-----PMPLQLEAHLRSHGLEPA-APSPRLRPEESLDPPG 878
Query: 1316 GTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEE 1375
LGA PP+PG + PP + A A P+P G A + +
Sbjct: 879 AMQELLGALEPLPPAPGDTGV----GPPNSEGKDPAGAYRSPSP-----QGTKAPRFVPL 929
Query: 1376 TSACLAAALQAVEEK 1390
TS C +L EE+
Sbjct: 930 TSICFPDSLLQDEER 944
Score = 90.1 bits (222), Expect = 1e-17
Identities = 203/833 (24%), Positives = 274/833 (32%), Gaps = 154/833 (18%)
Query: 632 ESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTGPAEVGPTTEKPSSHLPPTPRATTR 691
+SPPPP PT Q ++ D P ++ P+ SH P + ++
Sbjct: 762 KSPPPPPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSV---LSHAPSPSPSASK 818
Query: 692 QDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSI 751
L A + Q PP P P+ + + +L G P P RP
Sbjct: 819 VGVHLLEPATRDGAPQPPPPPPPPPPPMPL-QLEAHLRSHGLEPAAPSPRLRP------- 870
Query: 752 KRASVPPVPGKPRQVL--------PPGTSHFTPPQTPTKTRPG-----SPQALGGPHGPA 798
S+ P PG +++L PG + PP + K G SPQ P
Sbjct: 871 -EESLDP-PGAMQELLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSPQGTKAPRF-V 927
Query: 799 PATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPT 858
P T+ P LL ER P Y P E E P A G PPP P
Sbjct: 928 PLTSICFP-DSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPEDEGDPKA-GAGPPPGPP 985
Query: 859 AVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPA------AAGPYATVQR 912
A P PGR ++P V A +GP+
Sbjct: 986 A-----YDPYGPYCPGRASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPP 1040
Query: 913 RVGRSHSVRAPAGADKNVNRSQSF-AVRP------------RKKGPPPPPPKRSSSALAS 959
APA K S F + +P R++ PP PK+ +
Sbjct: 1041 PPPPPPPPPAPASEPKGGLTSPIFCSTKPKKLLKTSSFHLLRRRDPPFQTPKKLYAQEYE 1100
Query: 960 ANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRA 1019
ADE D P D +R RR DL S + A LS +G
Sbjct: 1101 FE-ADEDKADV-PAD----IRLNPRRLPDLVSSCRSRPA-----------LSPLGDIDFC 1143
Query: 1020 ARRPPEGHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARR 1079
P P R P K K P R R L P T
Sbjct: 1144 PPNPGPDGPRRRGRKP-----------TKAKRDGPPRPRGRPRIRPLEVPTTA------- 1185
Query: 1080 GPGESADPGPFVEDGTGRQRPRGPSKGEA-GVEGPPLAKVEASATLKRRIR----AKQNQ 1134
GP ++ P + GR R RG EA G PL ++ ++ + + +
Sbjct: 1186 GPASASTPTDGAKKPRGRGRGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDA 1245
Query: 1135 QENVKFILTESDTVKRRPKAKEREAGPEPPPP----LSVYHNGTGTVRRRPASEQAG--P 1188
+S + + +AK +E + P ++ + + + +R P QAG P
Sbjct: 1246 ISGTDHNSLDSSLTREKIEAKIKEVEEKQPEMKSGFMASFLDFLKSGKRHPPLYQAGLTP 1305
Query: 1189 PELPPPPPPAEPPPTDLAHLPPL------PPPEG-----------EARKPAKPPVSPKPV 1231
P PP P P L PP PPP G E+ SP
Sbjct: 1306 PLSPPKSVPPSVPARGLQPQPPATPAVPHPPPSGAFGLGGALEAAESEGLGLGCPSPCKR 1365
Query: 1232 LTQPVPK-LQGSPTPTS-------KKVPLPGPGSPEVKRAHGTPPPVSPK----PPPPPT 1279
L + + + L+ P+ +S K L S + A PP PK P PP
Sbjct: 1366 LDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAIS-ALDDPPLAGPKDTSTPDGPPL 1424
Query: 1280 APKPV----KAVAGLPSGSAG---------------PSPAPSPARQPPAALAKP----PG 1316
AP + GLPS ++ P PAP+P QPP P P
Sbjct: 1425 APAAAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQPALPS 1484
Query: 1317 TPPSLGASPAKPPSPGAPALHVPA--KPPRAAAAAAAAAAAPPAPPEGASPGD 1367
PP + +P+ PP P P PA PP AAA AAPP P SP D
Sbjct: 1485 PPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPEEPAAPSPED 1537
Score = 79.0 bits (193), Expect = 3e-14
Identities = 62/190 (32%), Positives = 71/190 (37%), Gaps = 27/190 (14%)
Query: 1195 PPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVL----TQPVPKLQGSPTPTSKKV 1250
PP A P T PPL P A P PP+ P T P L+ P PT
Sbjct: 1408 PPLAGPKDTSTPDGPPLAPA---AAVPGPPPLPGLPSANSNGTPEPPLLEEKPPPTPPPA 1464
Query: 1251 PLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAA 1310
P P P PPP P PPP P P P VA PS P P P P PPA
Sbjct: 1465 PTPQP----------QPPP--PPPPPQPALPSPPPLVAPTPS---SPPPPPLPPPPPPAM 1509
Query: 1311 LAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPR-----AAAAAAAAAAAPPAPPEGASP 1365
+ PP PP+ A P P AP+ P P A AA G S
Sbjct: 1510 PSPPPPPPPAAAPLAAPPEEPAAPSPEDPELPDTRPLHLAKKQETAAVCGETDEEAGESG 1569
Query: 1366 GDSARQKLEE 1375
G+ ++ +E
Sbjct: 1570 GEGIFRERDE 1579
Score = 73.6 bits (179), Expect = 1e-12
Identities = 67/223 (30%), Positives = 88/223 (39%), Gaps = 51/223 (22%)
Query: 1128 IRAKQNQQENVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAG 1187
+ ++ QE++ ++ D P A ++ PPL+ PA+ G
Sbjct: 1388 VAKNRDLQESISSAISALDDP---PLAGPKDTSTPDGPPLA------------PAAAVPG 1432
Query: 1188 PPELP----------PPPPPAE--PPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQP 1235
PP LP P PP E PPPT PP P P+ + P PP P+P L P
Sbjct: 1433 PPPLPGLPSANSNGTPEPPLLEEKPPPTP----PPAPTPQPQ---PPPPPPPPQPALPSP 1485
Query: 1236 VPKLQGSPTPTSKKVP-LPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGS 1294
P + +PTP+S P LP P PPP P PPPPP P +A P
Sbjct: 1486 PPLV--APTPSSPPPPPLPPP-----------PPPAMPSPPPPP--PPAAAPLAAPPEEP 1530
Query: 1295 AGPSPA-PSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPAL 1336
A PSP P P LAK T G + + G +
Sbjct: 1531 AAPSPEDPELPDTRPLHLAKKQETAAVCGETDEEAGESGGEGI 1573
Score = 64.3 bits (155), Expect = 8e-10
Identities = 160/735 (21%), Positives = 217/735 (29%), Gaps = 176/735 (23%)
Query: 668 PAEVGPTTEKPSSHLPPTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEY 727
P EV PTT P+S PT A + GR R E G P P+ + +
Sbjct: 1178 PLEV-PTTAGPASASTPTDGAKKPR-----GRGRGRGRKAEEAGGTRLEPLKPL-KIKLS 1230
Query: 728 LLDEGPAPGTPPREARPGRHGHSIK--------RASVPPVPGKPRQV-----------LP 768
+ G GT +A G +S+ A + V K ++ L
Sbjct: 1231 VPKAGEGLGTSSGDAISGTDHNSLDSSLTREKIEAKIKEVEEKQPEMKSGFMASFLDFLK 1290
Query: 769 PGTSH-------FTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPR 821
G H TPP +P K+ P S A G P PAT V PP
Sbjct: 1291 SGKRHPPLYQAGLTPPLSPPKSVPPSVPARGLQPQP-PATPAVPH-----PPPSGAFGLG 1344
Query: 822 SLPQSPTHRGFAYVLPQPV-------------------EGEVGPAAPGPAPPPVPTAVPT 862
++ G P P + E A + +A+
Sbjct: 1345 GALEAAESEGLGLGCPSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISA 1404
Query: 863 LCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAA--GPYATVQRRVGRSHSV 920
L PP A PK + D P L PAAA GP S+
Sbjct: 1405 LDDPPLAG-----PKDTS-------TPDGPP-----LAPAAAVPGPPPLPGLPSANSNGT 1447
Query: 921 RAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEPVPDAEPEDGLLGVR 980
P ++ + A P+ + PPPPPP + AL S P P + P L
Sbjct: 1448 PEPPLLEEKPPPTPPPAPTPQPQPPPPPPPPQP--ALPSPPPLVAPTPSSPPPPPL---- 1501
Query: 981 AQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPEPGRV 1040
PP P P P P
Sbjct: 1502 -----------------------------------------PPPPPPAMPSPPPPPPPAA 1520
Query: 1041 ATVLASVKHKEAIGPGGEVVNRRRTL----SGPVTGLLATARRGPGESADPGPFVEDGT- 1095
A + A + A P + R L + GES G F E
Sbjct: 1521 APLAAPPEEPAAPSPEDPELPDTRPLHLAKKQETAAVCGETDEEAGESGGEGIFRERDEF 1580
Query: 1096 ---GRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQE---------------- 1136
P + G E PP+ +V+ + K K Q++
Sbjct: 1581 VIRAEDIPSLKLALQTGREPPPIWRVQKALLQKFTPEIKDGQRQFCATSNYLGYFGDAKN 1640
Query: 1137 -----NVKFILTESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPEL 1191
VKF+ + V ++ + P PP+ V +G A PP+
Sbjct: 1641 RYQRLYVKFL----ENVNKKDYVRVCARKPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKA 1696
Query: 1192 PPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVP 1251
P PPP E P + PP PE +PP KP L +PV K + T + P
Sbjct: 1697 PAPPPKPETPEKTTSEKPPEQTPE---TAMPEPPAPEKPSLLRPVEKEKEKEKVTRGERP 1753
Query: 1252 LPG----------------PGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSA 1295
L G G P R P PPP K +K G +
Sbjct: 1754 LRGERATSGRQTRPERSLATGQPATSRLPKARPTKVKAEPPPKKRKKWLKEAGGNATAGG 1813
Query: 1296 GPSPAPSPARQPPAA 1310
GP + S + P A
Sbjct: 1814 GPPGSSSDSESSPGA 1828
Score = 60.1 bits (144), Expect = 2e-08
Identities = 69/264 (26%), Positives = 90/264 (34%), Gaps = 51/264 (19%)
Query: 620 RKAPQSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTG------PAEVGP 673
+ P S+ ++ PP TPA P F L L+AA + P+
Sbjct: 1311 KSVPPSVPARGLQPQPPA--TPAVPHPPPSGAFG---LGGALEAAESEGLGLGCPSPCKR 1365
Query: 674 TTEKPSSHLPPTPRATTRQDSSLGGRA---RHMSSSQELLGDGP-PGPSSPMSRSQEYLL 729
E+ +L P ++ ++ S+ +SS+ L D P GP + L
Sbjct: 1366 LDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTSTPDGPPLA 1425
Query: 730 DEGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQ 789
PG PP P + + P P + PP TPP PT PQ
Sbjct: 1426 PAAAVPGPPPLPGLPSANSNGT------PEPPLLEEKPPP-----TPPPAPT------PQ 1468
Query: 790 ALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAP 849
P P P A P P + P P P P P PA P
Sbjct: 1469 PQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPP------------------PAMP 1510
Query: 850 GPAPPPVPTAVPTLCLPPEADAEP 873
P PPP P A P L PPE A P
Sbjct: 1511 SPPPPPPPAAAP-LAAPPEEPAAP 1533
Score = 58.5 bits (140), Expect = 4e-08
Identities = 158/658 (24%), Positives = 211/658 (32%), Gaps = 114/658 (17%)
Query: 776 PPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYV 835
PP T T+P L GP P PQLLP +S P SP+
Sbjct: 767 PPPTAQSTQPTPHGLLLEAGGPDLPLVLPPPPPQLLPSV---LSHAPSP-SPSASKVGVH 822
Query: 836 LPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPER 895
L +P + P P P PPP P +P + +A R+H L A S
Sbjct: 823 LLEPATRDGAPQPPPPPPPPPPP------MPLQLEAH-----LRSHGLEPAAPSPRLRPE 871
Query: 896 DELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPRKKGPPPPPPKRSSS 955
+ L P A +Q +G + PA D V S P P P + +
Sbjct: 872 ESLDPPGA------MQELLGALEPL-PPAPGDTGVGPPNSEGKDPAGAYRSPSP--QGTK 922
Query: 956 ALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIGG 1015
A L PD+ +D + D G AG + G
Sbjct: 923 APRFVPLTSICFPDSLLQDEERSFFPTMEEMFGGGAADDYGKAGPPED----------EG 972
Query: 1016 GGRAARRPPEGHPTPRPASPE-PGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGL- 1073
+A PP G P P P PGR AS E G G + N+ L V
Sbjct: 973 DPKAGAGPPPGPPAYDPYGPYCPGR-----ASGAGPETPGLGLDP-NKPPELPSTVNAEP 1026
Query: 1074 LATARRGPGESADPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRR----IR 1129
L + GP ++A P P P S+ + G+ P + LK +R
Sbjct: 1027 LGLIQSGPHQAAPPPP----PPPPPPPAPASEPKGGLTSPIFCSTKPKKLLKTSSFHLLR 1082
Query: 1130 AKQNQQENVKFILT-----ESDTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASE 1184
+ + K + E+D K A R P P L + R RPA
Sbjct: 1083 RRDPPFQTPKKLYAQEYEFEADEDKADVPADIR-LNPRRLPDL------VSSCRSRPALS 1135
Query: 1185 QAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPT 1244
G + PP P + P P +G R +P + P V T P +PT
Sbjct: 1136 PLGDIDFCPPNPGPDGPRRR-GRKPTKAKRDGPPRPRGRPRIRPLEVPTTAGPASASTPT 1194
Query: 1245 PTSKKVPLPGPG-SPEVKRAHGTP----PPVSPKPPPPPTAP----KPVKAVAGLPSGSA 1295
+KK G G + + A GT P+ K P A++G S
Sbjct: 1195 DGAKKPRGRGRGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAISGTDHNSL 1254
Query: 1296 GPSPA------------------------------PSPARQPPA-------ALAKPPGTP 1318
S S R PP L+ P P
Sbjct: 1255 DSSLTREKIEAKIKEVEEKQPEMKSGFMASFLDFLKSGKRHPPLYQAGLTPPLSPPKSVP 1314
Query: 1319 PSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPEGASPG-DSARQKLEE 1375
PS+ A +P P PA VP PP A A A A EG G S ++L+E
Sbjct: 1315 PSVPARGLQPQPPATPA--VPHPPPSGAFGLGGALEA--AESEGLGLGCPSPCKRLDE 1368
Score = 54.3 bits (129), Expect = 8e-07
Identities = 202/900 (22%), Positives = 280/900 (31%), Gaps = 215/900 (23%)
Query: 624 QSLEVMAIESPPPPEPTPADCQSPKMTTFQDSELSDELQAAMTG-PAEVGPTTEKPSSHL 682
Q L S PP+P P+ P + T Q S D+LQ + G E P S L
Sbjct: 467 QDLSKAPSYSGGPPQP-PSGPPPPGLATCQ-SYSPDQLQGQLYGVQGEPYPGPAAHSQGL 524
Query: 683 P---PTPRATTRQDSSLGGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPAPGTPP 739
P P+ +T +L G S LG G S + R L PA G PP
Sbjct: 525 PTASPSLSYSTGHSPALSGHGGGWGPSS--LGGGGEASPSHIIRP----LQSPPATGRPP 578
Query: 740 REARPGRHGHSIKR--ASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGPHGP 797
PG G + AS P + PPG + K + + L GP GP
Sbjct: 579 GVGSPGAPGKYLSSVLASAP-------FLAPPGAGSYAAGAGGYKGKGDGSELLAGPGGP 631
Query: 798 APATAKVKPTPQLLPPTERPMSPRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVP 857
P ER L Q ++L P A
Sbjct: 632 ---------------PAERTEDEEFLIQ--------HLLQAPSPPRTSGADGLVGEDGAA 668
Query: 858 TAVPTLCLPPEADAEPGRPKKRAHSLNRYAASDSEPERDELL----VPAAAGPYATVQRR 913
A L A PG P Y + +P+R L A+ AT
Sbjct: 669 DASKGLGGSGGAGGPPGTP---------YELAKEDPQRYHLQSVIRTSASLDEGATAALE 719
Query: 914 VGRSHSVRAPAGADKNVNRSQSFAVRP-------------RKKGPPPPPPKRSSSA---- 956
+G G ++ + A +K PPPPPP S+
Sbjct: 720 LGLGRLKEKKKGPERGGETPEGLATSVVHYGAGAKELGAFLQKSPPPPPPTAQSTQPTPH 779
Query: 957 --LASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVDTGSAGSVKSIAAMLELSSIG 1014
L A D P+ P LL + + S + K +LE ++
Sbjct: 780 GLLLEAGGPDLPLVLPPPPPQLL---------PSVLSHAPSPSPSASKVGVHLLEPATRD 830
Query: 1015 GGGRAARRPPEGHPTPRPASPEPGRVATVLAS-----------VKHKEAIGPGGEVVNRR 1063
G A +PP P P P P P ++ L S ++ +E++ P G +
Sbjct: 831 G----APQPPP--PPPPPPPPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQE-- 882
Query: 1064 RTLSGPVTGLLATARRGPGESADPGPFVE--DGTGRQRPRGPSKGEAGVEGPPLAKVEAS 1121
+ G L PG++ P E D G R P +A P +
Sbjct: 883 ------LLGALEPLPPAPGDTGVGPPNSEGKDPAGAYRSPSPQGTKAPRFVPLTSICFPD 936
Query: 1122 ATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKERE----AGPEPPPPLSVYH------ 1171
+ L+ R+ E + D K P E + AGP P PP +
Sbjct: 937 SLLQDEERSFFPTMEEMFGGGAADDYGKAGPPEDEGDPKAGAGPPPGPPAYDPYGPYCPG 996
Query: 1172 --NGTG------------------TVRRRPAS------EQAGPPELPPPPPPAEPP---- 1201
+G G TV P QA PP PPPPPP P
Sbjct: 997 RASGAGPETPGLGLDPNKPPELPSTVNAEPLGLIQSGPHQAAPPPPPPPPPPPAPASEPK 1056
Query: 1202 -----------------PTDLAHL-----PPLPPP-------------EGEARKPAKPPV 1226
T HL PP P E +A PA +
Sbjct: 1057 GGLTSPIFCSTKPKKLLKTSSFHLLRRRDPPFQTPKKLYAQEYEFEADEDKADVPADIRL 1116
Query: 1227 SPKPVLTQPVPKLQGSPTPTSKKVPL-------PGPGSPEVKRAHGTPPPVSPKPPPPPT 1279
+P+ +P L S PL P PG P+ R G P + + PP
Sbjct: 1117 NPR-----RLPDLVSSCRSRPALSPLGDIDFCPPNPG-PDGPRRRGRKPTKAKRDGPPRP 1170
Query: 1280 APKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVP 1339
+P +P+ +AGP+ A +P KP G G K G L P
Sbjct: 1171 RGRPRIRPLEVPT-TAGPASASTPT----DGAKKPRGRGRGRG---RKAEEAGGTRLE-P 1221
Query: 1340 AKPPRAAAAAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGP 1399
KP + + A G S GD A + S + + +E KI++ + + P
Sbjct: 1222 LKPLKIKLSVPKAGEG-----LGTSSGD-AISGTDHNSLDSSLTREKIEAKIKEVEEKQP 1275
Score = 53.9 bits (128), Expect = 1e-06
Identities = 131/601 (21%), Positives = 191/601 (31%), Gaps = 102/601 (16%)
Query: 661 LQAAMTGPAEVGPTTEKPSSHLPPTPRATTRQDS-------SLGGRARHMSSSQELLGDG 713
L ++ P V P+ P+ L P P AT LGG ++ E LG G
Sbjct: 1303 LTPPLSPPKSVPPSV--PARGLQPQPPATPAVPHPPPSGAFGLGGALE--AAESEGLGLG 1358
Query: 714 PPGPSSPMSRSQEYLLDEGPAPGTPPREARPGRH------GHSIKRASVPPVPGKPRQVL 767
P P + + L+ P+ + ++ +I PP+ G
Sbjct: 1359 CPSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLAGPKDTST 1418
Query: 768 PPGTSHFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLL---PPTERPMSPRSLP 824
P G PP P PG P G P + T P P LL PP P +P P
Sbjct: 1419 PDG-----PPLAPAAAVPGPPPLPGLPSANSNGT----PEPPLLEEKPPPTPPPAPTPQP 1469
Query: 825 QSPTHRGFAY-VLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRPKKRAHSL 883
Q P LP P V P P PPP+P P P P A
Sbjct: 1470 QPPPPPPPPQPALPSPPP-LVAPTPSSPPPPPLPPPPPPAMPSPPPPPPPAAAPLAAPPE 1528
Query: 884 NRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSFAVRPR-- 941
A S +PE + P G + +G + F +R
Sbjct: 1529 EPAAPSPEDPELPDTR-PLHLAKKQETAAVCGETDEEAGESGGEGIFRERDEFVIRAEDI 1587
Query: 942 -------KKGPPPPPPKRSSSALASANLADEPVPDAEPEDGLLGVRAQCRRASDLAGSVD 994
+ G PPP R A L + P+ + G R C ++ L
Sbjct: 1588 PSLKLALQTGREPPPIWRVQKA-----LLQKFTPEIKD-----GQRQFCATSNYL----- 1632
Query: 995 TGSAGSVKSIAAMLELSSIGGGGR------AARRPPEGHPTPRPASPEPGRVATVLASVK 1048
G G K+ L + + + AR+P P P V S +
Sbjct: 1633 -GYFGDAKNRYQRLYVKFLENVNKKDYVRVCARKPWHRPPVP------------VRRSGQ 1679
Query: 1049 HKEAIGPGGEVVNRRRTLS---GPVTGLLATARRGP---GESADPGPFVEDGTGRQRPRG 1102
K + GG + + P T T+ + P E+A P P + RP
Sbjct: 1680 AKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETAMPEPPAPEKPSLLRPVE 1739
Query: 1103 PSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTESDTVKRRPKAKEREAGPE 1162
K E + + E +R +Q + E + + T R PKA+ + E
Sbjct: 1740 KEK-----EKEKVTRGERPLRGERATSGRQTRPE--RSLATGQPATSRLPKARPTKVKAE 1792
Query: 1163 PPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPA 1222
PPP +R+ ++AG PP ++ + P P E E P
Sbjct: 1793 PPPK-----------KRKKWLKEAGGNATAGGGPPGSSSDSESS---PGAPSEDERAVPG 1838
Query: 1223 K 1223
+
Sbjct: 1839 R 1839
Score = 52.4 bits (124), Expect = 3e-06
Identities = 150/661 (22%), Positives = 199/661 (30%), Gaps = 102/661 (15%)
Query: 713 GPPGPSSPMSRSQEYLLDEGPAPGTPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTS 772
G GP + + L GP PG S + A P P T
Sbjct: 80 GSAGPDASVMNLISALESRGPQPGPSASSLLSQFRSPSWQTAMHTPGP----------TE 129
Query: 773 HFTPPQTPTKTRPGSPQALGGPHGPAPATAKVKPTPQLLPPTERPMS------------- 819
F P + S AL PA ++ P P L + P S
Sbjct: 130 LFISGALPGSSTFPSSSALSAYQHPASFGSRPFPVPSSLSLQDPPFSPPANGLLSPHDVL 189
Query: 820 ---PRSLPQSPTHRGFAYVLPQPVEGEVGPAAPGPAPPPVPTAVPTLCLPPEADAEPGRP 876
P P P+ GF + G +GPA GPA P P PP+ P P
Sbjct: 190 HLKPSQAPTVPSSLGFERLAG---GGVLGPAGLGPAQTP-----PYRPGPPD---PPPPP 238
Query: 877 KKRAHSLNRYAASDSEPERDELLVPAAAGPYATVQRRVGRSHSVRAPAGADKNVNRSQSF 936
+ N A+S + AAA + + S + P ++ + R +
Sbjct: 239 RHLPTQFNLLASSSA----------AAAAAEQSSPQLYNFSGAAPGPPPPERALPRQDTV 288
Query: 937 A---VRPRKKGPPPPPPKRSS------------SALASANLADEPVPDAEPEDGL----- 976
RP PPPPPP + S ANLA P+ EP G
Sbjct: 289 IKHYQRPASAQPPPPPPPAHALQHYLSCGGSYPSMGHRANLACSPLGGGEPSPGAGEPSK 348
Query: 977 LGVRAQCRRAS------DLAGSVDTGSAGS-----VKSIAAMLELSSIGGGGRAARRPPE 1025
G AS + AG G G ++S G A RPP
Sbjct: 349 AGPSGATAGASGRATGPEAAGGGGAGGGGGGYRPIIQSPGYKTGKGGYGAAAGGATRPPP 408
Query: 1026 GHPTPRPASPEPGRVATVLASVKHKEAIGPGGEVVNRRRTLSGPVTGLLATARRGPGESA 1085
T P G A A+ K A G GG+ + G GLL G G
Sbjct: 409 PRSTATPKCQSLGGPAAAYATGKASGAGGAGGQAYS-----PGQPQGLLGPQAYGQGFGG 463
Query: 1086 DPGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQNQQENVKFILTES 1145
G + GP + +G P LA ++ + + + + Q E S
Sbjct: 464 --GQAQDLSKAPSYSGGPPQPPSGPPPPGLATCQSYSPDQLQGQLYGVQGEPYPGPAAHS 521
Query: 1146 DTVKRRPKAKEREAGPEPPPPLSVYHNGTGTVRRRPASEQAGPPEL--PPPPPPAEPPPT 1203
+ + G P LS + G G E A P + P PPA P
Sbjct: 522 QGLPTASPSLSYSTGHS--PALSGHGGGWGPSSLGGGGE-ASPSHIIRPLQSPPATGRPP 578
Query: 1204 DLAHLPPLPPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKRA 1263
+ P P + + A P P G L GPG P +R
Sbjct: 579 GVG--SPGAPGKYLSSVLASAPFLAPPGAGSYAAGAGGYKGKGDGSELLAGPGGPPAERT 636
Query: 1264 HGTP---PPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPS 1320
+ P PP T+ GL G G + A S PPGTP
Sbjct: 637 EDEEFLIQHLLQAPSPPRTS-----GADGL-VGEDGAADA-SKGLGGSGGAGGPPGTPYE 689
Query: 1321 L 1321
L
Sbjct: 690 L 690
Score = 35.4 bits (80), Expect = 0.40
Identities = 43/178 (24%), Positives = 61/178 (34%), Gaps = 65/178 (36%)
Query: 1251 PLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPA- 1309
P PGP + + +P + P PT + LP S PS + A Q PA
Sbjct: 100 PQPGPSASSLLSQFRSPSWQTAMHTPGPTE---LFISGALPGSSTFPSSSALSAYQHPAS 156
Query: 1310 ------------ALAKPPGTPPS------------------------------------- 1320
+L PP +PP+
Sbjct: 157 FGSRPFPVPSSLSLQDPPFSPPANGLLSPHDVLHLKPSQAPTVPSSLGFERLAGGGVLGP 216
Query: 1321 LGASPAK-------PPSPGAPALHVPAKPPRAAAAAAAAAAAPPAPPE-----GASPG 1366
G PA+ PP P P H+P + A+++AAAAAA + P+ GA+PG
Sbjct: 217 AGLGPAQTPPYRPGPPDPPPPPRHLPTQFNLLASSSAAAAAAEQSSPQLYNFSGAAPG 274
Score = 34.7 bits (78), Expect = 0.68
Identities = 32/136 (23%), Positives = 49/136 (36%), Gaps = 15/136 (11%)
Query: 362 GSSSSGPSAPP--EEIWVLRKPFAGGDRSGSISGMAGGRGSGGHALHAGSEGVKLL---- 415
G+++ G + PP + GG + +G A G G G ++ + LL
Sbjct: 397 GAAAGGATRPPPPRSTATPKCQSLGGPAAAYATGKASGAGGAGGQAYSPGQPQGLLGPQA 456
Query: 416 ---------ATVLSQKSVSESGPGDSPAKPPEGSAGVARSQPPVAHAGQVYGEQPPKKLE 466
A LS+ GP P+ PP +S P GQ+YG Q
Sbjct: 457 YGQGFGGGQAQDLSKAPSYSGGPPQPPSGPPPPGLATCQSYSPDQLQGQLYGVQGEPYPG 516
Query: 467 PASEGKSSEAVSQWLT 482
PA+ + S L+
Sbjct: 517 PAAHSQGLPTASPSLS 532
Score = 33.9 bits (76), Expect = 1.2
Identities = 30/117 (25%), Positives = 40/117 (34%), Gaps = 18/117 (15%)
Query: 1300 APSPARQPPAALAKP--PGTPPSLGAS-------PAKPPSPGAPALHVPAKPPRAAAAAA 1350
A P +PP + + P S G S PA PP P P KPP A
Sbjct: 1663 ARKPWHRPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPETA 1722
Query: 1351 AAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGPRDSAAEKS 1407
P P P + ++K + T E +R E A R + E+S
Sbjct: 1723 MPEPPAPEKPSLLRPVEKEKEKEKVTRG---------ERPLRGERATSGRQTRPERS 1770
Score = 30.8 bits (68), Expect = 9.8
Identities = 21/73 (28%), Positives = 29/73 (39%), Gaps = 6/73 (8%)
Query: 1273 KPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQP----PAALAKPPGTPPSLGASPAKP 1328
+PP P K SA P AP+P +P KPP P + +P
Sbjct: 1669 RPPVPVRRSGQAKNPVSAGGSSAPPPKAPAPPPKPETPEKTTSEKPPEQTPE--TAMPEP 1726
Query: 1329 PSPGAPALHVPAK 1341
P+P P+L P +
Sbjct: 1727 PAPEKPSLLRPVE 1739
>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
Length = 1430
Score = 112 bits (281), Expect = 2e-24
Identities = 85/287 (29%), Positives = 136/287 (47%), Gaps = 14/287 (4%)
Query: 11 VKAEDVGTAQRLLQRPRPGKAKLLG--STKKINVNFQDPDGFSALHHAALNGNTELISLL 68
+ +D G + + R G L S K ++ +D G ALH AA G+ ++ LL
Sbjct: 405 IDVQDKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLL 464
Query: 69 LEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHY 128
+ +I+D + PLH AAW G K + +AG VNI + EG PL A+ G++
Sbjct: 465 CSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYH 524
Query: 129 DVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPN 188
D+ E L +H ++ D G L LA ++ V++ LLS D D +
Sbjct: 525 DIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFV--------DYQDRH 576
Query: 189 GTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINA 247
G +PLH+A K+G++ I+ L +A +++ K G T LH AA G +VVR L G +
Sbjct: 577 GNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASV 636
Query: 248 HVRNTYSQTALDIVHQFTTSQASREIKQLLREASAAL---QVRATKD 291
T +TA D+ + + +L ++ L Q+R T++
Sbjct: 637 EALTTDGKTAEDLARSEQHEHVAGLLARLRKDTHRGLFIQQLRPTQN 683
Score = 111 bits (277), Expect = 6e-24
Identities = 81/281 (28%), Positives = 134/281 (47%), Gaps = 19/281 (6%)
Query: 28 PGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLH 87
PG LLGS +VN + G L AA GN +++ LL++ + +D++D G ++
Sbjct: 358 PGLQHLLGSLSNYDVNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVY 417
Query: 88 YAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNS 147
+AA G + +K + + +++ G + LH+AA++GH DV+++L SNP + D
Sbjct: 418 WAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKE 477
Query: 148 GKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRL 207
+TPL A G V + L + C ++ R G+ +PL A+ G+ DI+
Sbjct: 478 EETPLHCAAWHGYYSVAKALCEAG-CNVNIKNREGE-------TPLLTASARGYHDIVEC 529
Query: 208 LLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTT 266
L + G D+N K G ALH A + EV++ LL G ++ + T L +
Sbjct: 530 LAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHV----AC 585
Query: 267 SQASREIKQLLREASAALQVRATKDYCNNYDLTSLNVKAGD 307
+ I L EA+ L D N Y T L++ A +
Sbjct: 586 KDGNMPIVVALCEANCNL------DISNKYGRTPLHLAANN 620
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 111 bits (278), Expect = 4e-24
Identities = 70/215 (32%), Positives = 115/215 (53%), Gaps = 11/215 (5%)
Query: 33 LLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQ 92
+L I++N D G +ALH AAL+G+ + LLLE A VD D PL A
Sbjct: 341 MLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEM 400
Query: 93 GRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPL 152
G K+ ++ ++K G+ V++ +GH LH AA G+ DV ++L++++ NP + D +G+TPL
Sbjct: 401 GHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 460
Query: 153 DLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAG 212
A G + + +L+ +N +P + D G + LH + NG++D I+LLL
Sbjct: 461 QCAAYGGYINCMAVLMENN-----ADP---NIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512
Query: 213 IDINRQTKSG---TALHEAALCGKTEVVRLLLDSG 244
N+ + T L A L + EV++ +L+ G
Sbjct: 513 AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547
Score = 97.8 bits (242), Expect = 7e-20
Identities = 77/230 (33%), Positives = 116/230 (50%), Gaps = 12/230 (5%)
Query: 33 LLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDI-KDNKGMRPLHYAAW 91
+L S + N+ D + LH AAL G+ +++ LLLE + I D++G PLHYAA
Sbjct: 239 VLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQ 298
Query: 92 QGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPC--MVDNSGK 149
E +K+ LK S + EG AA G DV +L +S+ M D G
Sbjct: 299 SNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG 358
Query: 150 TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209
T L A G V V+LLL +N DATD +PL A + GH D+I+ L+
Sbjct: 359 TALHAAALSGHVSTVKLLLENNAQV--------DATDVMKHTPLFRACEMGHKDVIQTLI 410
Query: 210 QAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTAL 258
+ G ++ + G + LH AAL G +V ++L+++ IN +V++ +T L
Sbjct: 411 KGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 460
Score = 85.5 bits (210), Expect = 3e-16
Identities = 80/293 (27%), Positives = 116/293 (39%), Gaps = 71/293 (24%)
Query: 37 TKKINVNFQDPDGFSALHHAALNGNTELISLLLE--AQAAVDIKDNKGMRPLHYAAWQGR 94
T++ N +D + + LH + + + ++LLL+ A VD +D LH++A+
Sbjct: 102 TRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNN 161
Query: 95 KEPMKLVLKAGSAVNIPSDEGHIPLHLAAQH----------------------------- 125
E +KL++K S + IP EG IPLH AA H
Sbjct: 162 PEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEG 221
Query: 126 ----------GHYDVSEMLLQHQS-NPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCA 174
G+ V ++L ++S N DN +TPL A G +V LLL N
Sbjct: 222 RTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSG 281
Query: 175 A--------------------------LLEPRPGDATDPNGTSPLHLAAKNGHIDIIR-- 206
L P D +D G + AA G D++R
Sbjct: 282 TIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTM 341
Query: 207 LLLQAGIDINRQTK-SGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTAL 258
L L++ IDIN K GTALH AAL G V+LLL++ + T L
Sbjct: 342 LSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPL 394
Score = 68.2 bits (165), Expect = 6e-11
Identities = 58/194 (29%), Positives = 86/194 (44%), Gaps = 8/194 (4%)
Query: 38 KKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAV-DIKDNKGMRPLHYAAWQGRKE 96
K N+ F S +H AA+NG+ + L+ +A+ D +D G PL Y R +
Sbjct: 3 KSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLD 62
Query: 97 PMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLAC 156
+LKAG+ VN LHLAAQ G+Y ++LL ++N D TPL L
Sbjct: 63 CADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTT 122
Query: 157 EFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDIN 216
+ LLL + P D D N + LH +A + + ++LL++ +I
Sbjct: 123 RHRSPKCLALLLK------FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 217 RQTKSG-TALHEAA 229
G LH AA
Sbjct: 177 IPDVEGKIPLHWAA 190
Score = 37.0 bits (84), Expect = 0.14
Identities = 38/129 (29%), Positives = 53/129 (41%), Gaps = 12/129 (9%)
Query: 159 GRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQ 218
G G +Q L+ N D D G +PL +D LL+AG D+N+
Sbjct: 25 GDKGALQRLIVGNSALK-------DKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 219 TKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLL 277
S TALH AA G ++LLL N ++ T L + TT S + LL
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL----TTRHRSPKCLALL 133
Query: 278 REASAALQV 286
+ A +V
Sbjct: 134 LKFMAPGEV 142
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 111 bits (278), Expect = 4e-24
Identities = 70/215 (32%), Positives = 115/215 (53%), Gaps = 11/215 (5%)
Query: 33 LLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQ 92
+L I++N D G +ALH AAL+G+ + LLLE A VD D PL A
Sbjct: 341 MLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEM 400
Query: 93 GRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPL 152
G K+ ++ ++K G+ V++ +GH LH AA G+ DV ++L++++ NP + D +G+TPL
Sbjct: 401 GHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 460
Query: 153 DLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAG 212
A G + + +L+ +N +P + D G + LH + NG++D I+LLL
Sbjct: 461 QCAAYGGYINCMAVLMENN-----ADP---NIQDKEGRTALHWSCNNGYLDAIKLLLDFA 512
Query: 213 IDINRQTKSG---TALHEAALCGKTEVVRLLLDSG 244
N+ + T L A L + EV++ +L+ G
Sbjct: 513 AFPNQMENNEERYTPLDYALLGERHEVIQFMLEHG 547
Score = 97.8 bits (242), Expect = 7e-20
Identities = 77/230 (33%), Positives = 116/230 (50%), Gaps = 12/230 (5%)
Query: 33 LLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDI-KDNKGMRPLHYAAW 91
+L S + N+ D + LH AAL G+ +++ LLLE + I D++G PLHYAA
Sbjct: 239 VLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQ 298
Query: 92 QGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPC--MVDNSGK 149
E +K+ LK S + EG AA G DV +L +S+ M D G
Sbjct: 299 SNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGG 358
Query: 150 TPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLL 209
T L A G V V+LLL +N DATD +PL A + GH D+I+ L+
Sbjct: 359 TALHAAALSGHVSTVKLLLENNAQV--------DATDVMKHTPLFRACEMGHKDVIQTLI 410
Query: 210 QAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTAL 258
+ G ++ + G + LH AAL G +V ++L+++ IN +V++ +T L
Sbjct: 411 KGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 460
Score = 85.5 bits (210), Expect = 3e-16
Identities = 80/293 (27%), Positives = 116/293 (39%), Gaps = 71/293 (24%)
Query: 37 TKKINVNFQDPDGFSALHHAALNGNTELISLLLE--AQAAVDIKDNKGMRPLHYAAWQGR 94
T++ N +D + + LH + + + ++LLL+ A VD +D LH++A+
Sbjct: 102 TRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNN 161
Query: 95 KEPMKLVLKAGSAVNIPSDEGHIPLHLAAQH----------------------------- 125
E +KL++K S + IP EG IPLH AA H
Sbjct: 162 PEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEG 221
Query: 126 ----------GHYDVSEMLLQHQS-NPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCA 174
G+ V ++L ++S N DN +TPL A G +V LLL N
Sbjct: 222 RTPLHFAVADGNVTVVDVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSG 281
Query: 175 A--------------------------LLEPRPGDATDPNGTSPLHLAAKNGHIDIIR-- 206
L P D +D G + AA G D++R
Sbjct: 282 TIPSDSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTM 341
Query: 207 LLLQAGIDINRQTK-SGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTAL 258
L L++ IDIN K GTALH AAL G V+LLL++ + T L
Sbjct: 342 LSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPL 394
Score = 68.2 bits (165), Expect = 6e-11
Identities = 58/194 (29%), Positives = 86/194 (44%), Gaps = 8/194 (4%)
Query: 38 KKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAV-DIKDNKGMRPLHYAAWQGRKE 96
K N+ F S +H AA+NG+ + L+ +A+ D +D G PL Y R +
Sbjct: 3 KSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLD 62
Query: 97 PMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLAC 156
+LKAG+ VN LHLAAQ G+Y ++LL ++N D TPL L
Sbjct: 63 CADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTT 122
Query: 157 EFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDIN 216
+ LLL + P D D N + LH +A + + ++LL++ +I
Sbjct: 123 RHRSPKCLALLLK------FMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIG 176
Query: 217 RQTKSG-TALHEAA 229
G LH AA
Sbjct: 177 IPDVEGKIPLHWAA 190
Score = 37.0 bits (84), Expect = 0.14
Identities = 38/129 (29%), Positives = 53/129 (41%), Gaps = 12/129 (9%)
Query: 159 GRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQ 218
G G +Q L+ N D D G +PL +D LL+AG D+N+
Sbjct: 25 GDKGALQRLIVGNSALK-------DKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77
Query: 219 TKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLL 277
S TALH AA G ++LLL N ++ T L + TT S + LL
Sbjct: 78 DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL----TTRHRSPKCLALL 133
Query: 278 REASAALQV 286
+ A +V
Sbjct: 134 LKFMAPGEV 142
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 111 bits (277), Expect = 6e-24
Identities = 78/226 (34%), Positives = 110/226 (48%), Gaps = 14/226 (6%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
N+N D DG++AL AA G+TE++S LL A VD D L AAW G ++ +
Sbjct: 603 NINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLN 662
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLA----- 155
+L+ G+ VN +EG L AA GH ++ E LL H + D G+T L +A
Sbjct: 663 LLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVP 722
Query: 156 CEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDI 215
G VV LL+ D D +G +PL +AA GH+D++ LLL+ G D+
Sbjct: 723 ASKGHASVVSLLIDRG--------AEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADV 774
Query: 216 NRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
+ +G T L AA G VV LL G ++ +T L I
Sbjct: 775 DHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSI 820
Score = 100 bits (250), Expect = 8e-21
Identities = 78/251 (31%), Positives = 122/251 (48%), Gaps = 31/251 (12%)
Query: 42 VNFQDPDGFSALHHAAL-----NGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKE 96
VN +D DG +AL AAL G+ ++SLL++ A VD D GM PL AA++G +
Sbjct: 703 VNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVD 762
Query: 97 PMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLAC 156
+ L+L+ G+ V+ + G PL AA GH V LL + +D+ G+T L +A
Sbjct: 763 VVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIAS 822
Query: 157 EFGRVGVVQLLLSSNM------------------------CAALLEP-RPGDATDPNGTS 191
G V VV+ LL + C AL+E + D +G
Sbjct: 823 AQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRI 882
Query: 192 PLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDSGINAHVR 250
P LA++ GH D +++LL+ +I+++ G AL AAL G ++V LL G + + +
Sbjct: 883 PFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942
Query: 251 NTYSQTALDIV 261
+ + L I+
Sbjct: 943 DADGRPTLYIL 953
Score = 99.0 bits (245), Expect = 3e-20
Identities = 87/305 (28%), Positives = 136/305 (44%), Gaps = 40/305 (13%)
Query: 41 NVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKL 100
+V+ D +G + L AA G+ +++ LL AAVD D++G L A+ QG E ++
Sbjct: 773 DVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRT 832
Query: 101 VLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGR 160
+L G N D G PLH+AA GH + E L++ + +DN G+ P LA + G
Sbjct: 833 LLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGH 892
Query: 161 VGVVQLLL--SSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQ 218
VQ+LL SN+ D +G + L +AA GH DI+ LL G D+N +
Sbjct: 893 YDCVQILLENKSNI----------DQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCK 942
Query: 219 TKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALD--------------IVHQ 263
G L+ AL + + L++G N + +TAL I +
Sbjct: 943 DADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYH 1002
Query: 264 FTTSQASREIKQLLREASAALQVR---------ATKDYCNNYDLTSLNVKAG----DIIT 310
+ A E + L+ A+ V+ A D+ N T+L + A D++
Sbjct: 1003 ADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQ 1062
Query: 311 VLEQH 315
VL +H
Sbjct: 1063 VLLEH 1067
Score = 99.0 bits (245), Expect = 3e-20
Identities = 70/246 (28%), Positives = 124/246 (50%), Gaps = 11/246 (4%)
Query: 39 KINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPM 98
K N++ + DG +AL AAL G+ +++ LL A V+ KD G L+ A + +
Sbjct: 903 KSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMA 962
Query: 99 KLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEF 158
+ L+ G+ V EG LH++ GH ++ ++L+ + ++ DN ++ L A
Sbjct: 963 EYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQ 1022
Query: 159 GRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQ 218
G V VVQLL+ D T G + L +AA+ GHID++++LL+ G D N
Sbjct: 1023 GHVKVVQLLIEHGAVV--------DHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHA 1074
Query: 219 TKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLL 277
+ G TA+ AA G +++++LL G A N S + + + Q S +++ L
Sbjct: 1075 DQFGRTAMRVAAKNGHSQIIKLLEKYG--ASSLNGCSPSPVHTMEQKPLQSLSSKVQSLT 1132
Query: 278 REASAA 283
+++++
Sbjct: 1133 IKSNSS 1138
Score = 93.2 bits (230), Expect = 2e-18
Identities = 100/391 (25%), Positives = 175/391 (44%), Gaps = 58/391 (14%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
++ N +D G++ LH AA G+ + L+E A + DN G P A+ +G + ++
Sbjct: 838 LDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQ 897
Query: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFG 159
++L+ S ++ +G L +AA GH D+ E+L H ++ D G+ L +
Sbjct: 898 ILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALEN 957
Query: 160 RVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDIN-RQ 218
++ + + L + +A+D G + LH++ GH++++++L+ D+N
Sbjct: 958 QLTMAEYFLENGANV--------EASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAAD 1009
Query: 219 TKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQ--TALDIVHQFTTSQASREIKQL 276
+ +AL AA G +VV+LL++ G A V +T +Q TAL I Q + ++ Q+
Sbjct: 1010 NEKRSALQSAAWQGHVKVVQLLIEHG--AVVDHTCNQGATALCIAAQ----EGHIDVVQV 1063
Query: 277 LREASAALQVRATKDYCNNYDLTSLNVKA----GDIITVLEQHPDGRWKGCIHDNRTGND 332
L L+ A ++ + + T++ V A II +LE++ GC
Sbjct: 1064 L------LEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGASSLNGC--------- 1108
Query: 333 RVGYFPSSLGEAIVKRAGSRAGTEPSLPQGSSSSGPSAPPEEIWVLRKPFAGGDRSGSIS 392
PS + K S + SL S+SSG + GGD S+
Sbjct: 1109 ----SPSPVHTMEQKPLQSLSSKVQSLTIKSNSSGST-------------GGGDMQPSLR 1151
Query: 393 GMAGGRGSGGHALHAGSEGVKLLATVLSQKS 423
G+ G HA + SE +TV QKS
Sbjct: 1152 GLPNG---PTHAFSSPSESPD--STVDRQKS 1177
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 110 bits (274), Expect = 1e-23
Identities = 91/307 (29%), Positives = 136/307 (44%), Gaps = 65/307 (21%)
Query: 4 EQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDG--FSALHHAALNGN 61
+ L++A KA D+ T ++L NVN +D +G + LH AA
Sbjct: 651 DYRLLEASKAGDLETVKQLCSSQ--------------NVNCRDLEGRHSTPLHFAAGYNR 696
Query: 62 TELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHL 121
++ LL A V KD G+ PLH A G E +L+++ G++VN+ PLH
Sbjct: 697 VSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHE 756
Query: 122 AAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLL--------LSSNMC 173
AA G Y++ ++LL+H ++P + G TPLDL E G + LL + C
Sbjct: 757 AAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKE-GDTDIQDLLRGDAALLDAAKKGC 815
Query: 174 AA----LLEPRPGDATDPNG--TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG----- 222
A L P + D G ++PLHLAA ++++ LL+ G D+N Q K G
Sbjct: 816 LARVQKLCTPENINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLH 875
Query: 223 -----------------------------TALHEAALCGKTEVVRLLLDSGINAHVRNTY 253
T LHEAA G+T++ LLL G + ++N
Sbjct: 876 NAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQE 935
Query: 254 SQTALDI 260
QT LD+
Sbjct: 936 GQTPLDL 942
Score = 108 bits (269), Expect = 5e-23
Identities = 90/273 (32%), Positives = 133/273 (48%), Gaps = 30/273 (10%)
Query: 2 GKEQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDG--FSALHHAALN 59
G +EL++A + DV +RL+ NVN +D G S LH AA
Sbjct: 181 GALRELLEACRNGDVSRVKRLVDAA--------------NVNAKDMAGRKSSPLHFAAGF 226
Query: 60 GNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPL 119
G +++ LL+ A V +D+ G+ PLH A G E + L+L G+ N + + PL
Sbjct: 227 GRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPL 286
Query: 120 HLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLA---------CEFGRVGVVQLLLSS 170
H AA G DV +LLQH ++P + + GK+ LDLA E+ + +++ S
Sbjct: 287 HEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSG 346
Query: 171 N--MCAALLEPRPGD--ATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TAL 225
N ALL P + A+D ++PLHLAA + I++LLLQ G D++ + K G L
Sbjct: 347 NEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPL 406
Query: 226 HEAALCGKTEVVRLLLDSGINAHVRNTYSQTAL 258
H A G EV LLL G + + + T L
Sbjct: 407 HNACSYGHYEVTELLLKHGACVNAMDLWQFTPL 439
Score = 99.8 bits (247), Expect = 2e-20
Identities = 95/337 (28%), Positives = 147/337 (43%), Gaps = 60/337 (17%)
Query: 22 LLQRPRPG-KAKLLGSTKKINVNFQDPDGFSA--LHHAALNGNTELISLLLEAQAAVDIK 78
LL+ R G + KL+ +NVN DG + LH AA ++ LLL+ A V K
Sbjct: 339 LLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAK 398
Query: 79 DNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQ 138
D G+ PLH A G E +L+LK G+ VN PLH AA +V +LL H
Sbjct: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458
Query: 139 SNPCMVDNSGKTPLDLA----------CEFGRVGVVQLLLSSNM---------------- 172
++P +V+ GK+ +D+A EF ++Q +++
Sbjct: 459 ADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQ 518
Query: 173 ---------CA-ALLEPRPGDATD-------------PNGTSPLHLAAKNGHIDIIRLLL 209
CA A L P+ T+ + +PLH+AA+ H D++ +L
Sbjct: 519 PQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLH 578
Query: 210 QAGIDINR-QTKSGTALHEAALCGKTEVVRLLLDSGINAHVRN----TYSQTALDIVHQF 264
+ G +N T TALH AAL G + RLLL G + + + T +Q + V Q
Sbjct: 579 KHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQI 638
Query: 265 ---TTSQASREIKQLLREASAALQVRATKDYCNNYDL 298
+T + ++ L EAS A + K C++ ++
Sbjct: 639 LSESTPIRTSDVDYRLLEASKAGDLETVKQLCSSQNV 675
Score = 86.7 bits (213), Expect = 1e-16
Identities = 91/334 (27%), Positives = 135/334 (40%), Gaps = 73/334 (21%)
Query: 22 LLQRPRPGKAKLLGSTKKINV-NFQDPDGFSALHHAALNG----NTELISLLLEAQAAVD 76
LLQ R + T + + NF+ P H A+ ++ LLL A V+
Sbjct: 493 LLQAAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVN 552
Query: 77 IKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQ 136
K+ M PLH AA + + M+++ K G+ +N G LH AA GH +LL
Sbjct: 553 EKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLS 612
Query: 137 HQSNPCMVDNSGKTPLDLACEFGRVGVVQLL------LSSNMCAALLE-PRPGD------ 183
+ S+P ++ G T A + G V Q+L +S++ LLE + GD
Sbjct: 613 YGSDPSIISLQGFT----AAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVKQ 668
Query: 184 --------ATDPNG--TSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG----------- 222
D G ++PLH AA + ++ LL G D++ + K G
Sbjct: 669 LCSSQNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYG 728
Query: 223 -----------------------TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALD 259
T LHEAA GK E+ +LLL G + +N T LD
Sbjct: 729 HYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLD 788
Query: 260 IVHQFTTSQASREIKQLLREASAALQVRATKDYC 293
+V + T +I+ LLR +A L A K C
Sbjct: 789 LVKEGDT-----DIQDLLRGDAALLD--AAKKGC 815
Score = 77.8 bits (190), Expect = 7e-14
Identities = 78/278 (28%), Positives = 114/278 (41%), Gaps = 33/278 (11%)
Query: 30 KAKLLGSTKKINVNFQDPDGFSALHHAALNGNTE-LISLLLEAQAAVDIKDNKGMRPLHY 88
KA L G KK L AA +GN E L++LL D + PLH
Sbjct: 327 KAVLTGEYKK-----------DELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHL 375
Query: 89 AAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSG 148
AA R ++L+L+ G+ V+ G +PLH A +GHY+V+E+LL+H + +D
Sbjct: 376 AAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQ 435
Query: 149 KTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDP--------------NGTSPLH 194
TPL A RV V LLLS L+ A D G S L
Sbjct: 436 FTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQ 495
Query: 195 LAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAALC---GKTEVVRLLLDSGINAHVRN 251
A + + + L I+ + TALH A + +V LLL G N + +N
Sbjct: 496 AAREADLAKVKKTLALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKN 555
Query: 252 TYSQTALDIVHQFTTSQASREIKQLLREASAALQVRAT 289
T L + +A ++ ++L + A + T
Sbjct: 556 KDFMTPLHV----AAERAHNDVMEVLHKHGAKMNALDT 589
Score = 76.3 bits (186), Expect = 2e-13
Identities = 46/117 (39%), Positives = 64/117 (54%), Gaps = 2/117 (1%)
Query: 41 NVNFQDPDGFSA--LHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPM 98
N+N +D G ++ LH AA N E+ LLE A V+ +D G+ PLH AA G +
Sbjct: 827 NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIA 886
Query: 99 KLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLA 155
L++K + VN PLH AAQ G + +LL H ++P M + G+TPLDLA
Sbjct: 887 ALLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943
Score = 70.9 bits (172), Expect = 9e-12
Identities = 60/177 (33%), Positives = 87/177 (49%), Gaps = 15/177 (8%)
Query: 104 AGSAVNIPSDEGHI-PLHLAAQHGHYDVSEML-LQHQSNPCMVDNSGK--TPLDLACEFG 159
AG +P+ G + L A ++G DVS + L +N D +G+ +PL A FG
Sbjct: 170 AGPGTGVPAVSGALRELLEACRNG--DVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFG 227
Query: 160 RVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDIN-RQ 218
R VV+ LL A D G PLH A GH +++ LLL G D N R
Sbjct: 228 RKDVVEHLLQMGANV--------HARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARD 279
Query: 219 TKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQ 275
+ T LHEAA+ GK +V +LL G + ++RNT ++ALD+ + + E K+
Sbjct: 280 NWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKK 336
Score = 60.5 bits (145), Expect = 1e-08
Identities = 54/167 (32%), Positives = 79/167 (47%), Gaps = 18/167 (10%)
Query: 49 GFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMR--PLHYAAWQGRKEPMKLVLKAGS 106
G +AL AA G + L + ++ +D +G PLH AA E + +L+ G+
Sbjct: 803 GDAALLDAAKKGCLARVQKLCTPEN-INCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGA 861
Query: 107 AVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQL 166
VN G IPLH AA +GH D++ +L+++ + D TPL A + GR
Sbjct: 862 DVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEAAQKGR------ 915
Query: 167 LLSSNMCAALLEPRPGDATDPN--GTSPLHLAAKNGHIDIIRLLLQA 211
+ +CA LL D T N G +PL LA + DI LL+ A
Sbjct: 916 ---TQLCALLL-AHGADPTMKNQEGQTPLDLATAD---DIRALLIDA 955
Score = 51.2 bits (121), Expect = 7e-06
Identities = 60/241 (24%), Positives = 91/241 (37%), Gaps = 29/241 (12%)
Query: 1168 SVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPPLPPPEGEARKPAKPPVS 1227
S +H+ + +PA + PP PPPPPP P L P P P S
Sbjct: 7 SQHHHHHHQQQLQPAPGASAPP--PPPPPPLSPG------LAPGTTPASPTASGLAPFAS 58
Query: 1228 PKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAV 1287
P+ L +P+ GS P + P SP+ GT + A V AV
Sbjct: 59 PRHGLA--LPEGDGSRDPPDR------PRSPDP--VDGTSCCSTTSTICTVAAAPVVPAV 108
Query: 1288 AGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAA 1347
+ + P+PA S + P++ + P +S + P SPG+ A+ P AA
Sbjct: 109 STSSAAGVAPNPAGSGSNNSPSSSSSP------TSSSSSSPSSPGSSL----AESPEAAG 158
Query: 1348 AAAAAAAAPPAPPEGASPGDSARQKLEETSACLAAALQAVEEKIRQEDAQGPRDSAAEKS 1407
++ A P A G + E AC + V+ + + +D A KS
Sbjct: 159 VSSTAPLGPGAAGPGTGVPAVSGALRELLEACRNGDVSRVKRLVDAANVNA-KDMAGRKS 217
Query: 1408 T 1408
+
Sbjct: 218 S 218
Score = 41.2 bits (95), Expect = 0.007
Identities = 53/195 (27%), Positives = 69/195 (35%), Gaps = 60/195 (30%)
Query: 1161 PEPPPPLSVYHNGTGTVRRRPASEQAGPPELPPPPPPAEPPPTDLAHLPP----LPPPEG 1216
P PPPPLS P L P PA P + LA L PEG
Sbjct: 29 PPPPPPLS--------------------PGLAPGTTPASPTASGLAPFASPRHGLALPEG 68
Query: 1217 E-ARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKPP 1275
+ +R P P SP PV G+ ++ T V+ P
Sbjct: 69 DGSRDPPDRPRSPDPV--------DGTSCCSTT----------------STICTVAAAPV 104
Query: 1276 PPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPS--------LGASPAK 1327
P + VA P+GS G + +PS + P ++ + P +P S G S
Sbjct: 105 VPAVSTSSAAGVAPNPAGS-GSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVSSTA 163
Query: 1328 PPSPGA--PALHVPA 1340
P PGA P VPA
Sbjct: 164 PLGPGAAGPGTGVPA 178
Score = 38.1 bits (87), Expect = 0.061
Identities = 25/94 (26%), Positives = 48/94 (51%), Gaps = 7/94 (7%)
Query: 545 NLAVWLSMIGLAQYYKVLVDNGYENIDFITDITWEDLQEIGITKLGHQKKLMLAVRKLAE 604
N++ +L +GL ++ + + + +D + D+ E+L+EIGI GH+ KL+ V +L
Sbjct: 1030 NISQFLKSLGL-EHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLG 1088
Query: 605 LQKAE------YAKYEGGPLRRKAPQSLEVMAIE 632
Q+ + +G L AP+ E ++E
Sbjct: 1089 GQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVE 1122
Score = 36.6 bits (83), Expect = 0.18
Identities = 44/182 (24%), Positives = 60/182 (32%), Gaps = 37/182 (20%)
Query: 742 ARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGPHGPAPAT 801
+R +H H + + P PG PP PP +P G AP T
Sbjct: 4 SRRSQHHHHHHQQQLQPAPGASAPPPPP-----PPPLSP---------------GLAPGT 43
Query: 802 AKVKPTPQLLPPTERPMSPRSLPQ-----SPTHRGFAYVLPQPVEG--------EVGPAA 848
PT L P P +LP+ P R + P PV+G + A
Sbjct: 44 TPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRS---PDPVDGTSCCSTTSTICTVA 100
Query: 849 PGPAPPPVPTAVPTLCLP-PEADAEPGRPKKRAHSLNRYAASDSEPERDELLVPAAAGPY 907
P P V T+ P P P + + ++S S P P AAG
Sbjct: 101 AAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAESPEAAGVS 160
Query: 908 AT 909
+T
Sbjct: 161 ST 162
Score = 33.9 bits (76), Expect = 1.2
Identities = 53/227 (23%), Positives = 67/227 (29%), Gaps = 71/227 (31%)
Query: 931 NRSQSFAVRPRKKGPPPPPPKRSSSALASANLADEP-----VPDAEPEDGLLGVRAQCRR 985
+ Q P PPPPPP S LA P P A P GL
Sbjct: 13 HHQQQLQPAPGASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHGL--------- 63
Query: 986 ASDLAGSVDTGSAGSVKSIAAMLELSSIGGGGRAARRPPEGHPTPRPASPEP-------- 1037
A+ E G +R PP+ RP SP+P
Sbjct: 64 --------------------ALPE-------GDGSRDPPD-----RPRSPDPVDGTSCCS 91
Query: 1038 -------GRVATVLASVKHKEAIG----PGGEVVNRRRTLSGPVTGLLATARRGPGESAD 1086
A V+ +V A G P G N + S T +++ PG S
Sbjct: 92 TTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLA 151
Query: 1087 PGPFVEDGTGRQRPRGPSKGEAGVEGPPLAKVEASATLKRRIRAKQN 1133
P G P GP G GP S L+ + A +N
Sbjct: 152 ESPEAA-GVSSTAPLGP-----GAAGPGTGVPAVSGALRELLEACRN 192
Score = 33.1 bits (74), Expect = 2.0
Identities = 29/121 (23%), Positives = 39/121 (32%), Gaps = 15/121 (12%)
Query: 1293 GSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALHVPAKPPRAAAAAAAA 1352
G++ P P P P P A P +P + G +P P G A
Sbjct: 23 GASAPPPPPPPPLSPGLAPGTTPASPTASGLAPFASPRHG------------LALPEGDG 70
Query: 1353 AAAPPAPPEGASPGDSARQKLEETSACLAAA---LQAVEEKIRQEDAQGPRDSAAEKSTG 1409
+ PP P P D ++ C AA + AV A P S + S
Sbjct: 71 SRDPPDRPRSPDPVDGTSCCSTTSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPS 130
Query: 1410 S 1410
S
Sbjct: 131 S 131
>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
sapiens]
Length = 522
Score = 110 bits (274), Expect = 1e-23
Identities = 84/296 (28%), Positives = 139/296 (46%), Gaps = 38/296 (12%)
Query: 4 EQELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTE 63
E++L +A + +VG Q L+ R ++N ++ G ALH AA G+ +
Sbjct: 16 ERQLHEAARQNNVGRMQELIGR-------------RVNTRARNHVGRVALHWAAGAGHEQ 62
Query: 64 LISLLLEAQAAVDIKDNKG----------MRPLHYAAWQGRKEPMKLVLKAGSAVNIPSD 113
+ LLLE +AAVD +D G M L +AW G +++++ +G+ ++ S
Sbjct: 63 AVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESK 122
Query: 114 EGHIPLHLAAQHGHYDVSEMLLQHQSNPCM--VDNSGKTPLDLACEFGRVGVVQLLLSSN 171
+G LH AAQ GH V +++ + + VD G+T A E G++ + L+ S
Sbjct: 123 DGLTLLHCAAQKGHVPVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSG 182
Query: 172 MCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAAL 230
+ D G + LHLAA GH+ +++ L+ G+D+ Q G TALH AA
Sbjct: 183 C--------DHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAG 234
Query: 231 CGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQV 286
+ V+LLL +G N +Q L +H + S ++ ++L A V
Sbjct: 235 GSHPDCVQLLLRAGSTV---NALTQKNLSCLH-YAALSGSEDVSRVLIHAGGCANV 286
Score = 98.6 bits (244), Expect = 4e-20
Identities = 78/267 (29%), Positives = 135/267 (50%), Gaps = 12/267 (4%)
Query: 43 NFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVL 102
N +D +G +ALH AA G+ ++ L++ ++ ++ +G+ LH AA + ++L+L
Sbjct: 186 NVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLL 245
Query: 103 KAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVG 162
+AGS VN + + LH AA G DVS +L+ +VD+ G +PL LA
Sbjct: 246 RAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPA 305
Query: 163 VVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG 222
+V+LL++S+ +A D +PLHLAA++ DI +LL AG+D+N + K G
Sbjct: 306 LVRLLINSDSDV--------NAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQG 357
Query: 223 -TALHEAALCGKTEVVRLLL--DSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLL-R 278
TAL A +V +++ D + + + + Q +++++ +L R
Sbjct: 358 KTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSLSFKQDHRQETQQLRSVLWR 417
Query: 279 EASAALQVRATKDYCNNYDLTSLNVKA 305
AS LQ R K +++ T +V A
Sbjct: 418 LASRYLQPREWKKLAYSWEFTEAHVDA 444
Score = 88.6 bits (218), Expect = 4e-17
Identities = 49/172 (28%), Positives = 90/172 (52%), Gaps = 8/172 (4%)
Query: 40 INVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMK 99
+++ Q+ +G +ALH AA + + + LLL A + V+ K + LHYAA G ++ +
Sbjct: 216 LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSR 275
Query: 100 LVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFG 159
+++ AG N+ +G PLHLA +H + +L+ S+ VDN +TPL LA E
Sbjct: 276 VLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHA 335
Query: 160 RVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQA 211
+ +LL + + L D G + L +A ++ H+ ++ ++++A
Sbjct: 336 WQDIADMLLIAGVDLNL--------RDKQGKTALAVAVRSNHVSLVDMIIKA 379
Score = 87.4 bits (215), Expect = 9e-17
Identities = 62/234 (26%), Positives = 113/234 (48%), Gaps = 9/234 (3%)
Query: 28 PGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLH 87
P A ++ + + ++ D G +A H AA +G + + L+ + ++KD +G LH
Sbjct: 138 PVLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALH 197
Query: 88 YAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNS 147
AA +G ++ ++ G + + EG LH AA H D ++LL+ S +
Sbjct: 198 LAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQK 257
Query: 148 GKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRL 207
+ L A G V ++L+ + CA + D G SPLHLA ++ ++RL
Sbjct: 258 NLSCLHYAALSGSEDVSRVLIHAGGCA--------NVVDHQGASPLHLAVRHNFPALVRL 309
Query: 208 LLQAGIDINR-QTKSGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
L+ + D+N + T LH AA ++ +LL +G++ ++R+ +TAL +
Sbjct: 310 LINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAV 363
Score = 77.0 bits (188), Expect = 1e-13
Identities = 48/160 (30%), Positives = 82/160 (51%), Gaps = 6/160 (3%)
Query: 42 VNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLV 101
VN S LH+AAL+G+ ++ +L+ A ++ D++G PLH A ++L+
Sbjct: 251 VNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLL 310
Query: 102 LKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRV 161
+ + S VN + PLHLAA+H D+++MLL + + D GKT L +A V
Sbjct: 311 INSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHV 370
Query: 162 GVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGH 201
+V +++ ++ + P +DP+G S L+ K H
Sbjct: 371 SLVDMIIKADRFYRWEKDHP---SDPSGKS---LSFKQDH 404
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 108 bits (269), Expect = 5e-23
Identities = 80/211 (37%), Positives = 108/211 (51%), Gaps = 9/211 (4%)
Query: 51 SALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNI 110
+AL A G+ EL+ LLE A+++ +D KG PL AA G ++++L G+ +
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 111 PSDE-GHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLS 169
S+ PL LA G +V E+LL +N + S TPL LA G V ++++LL+
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
Query: 170 SNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQ--TKSGTALHE 227
+ A + R G G SPL LAA NGH ++LLL G DIN Q T TAL
Sbjct: 1205 A---GAEINSRTGSKL---GISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTL 1258
Query: 228 AALCGKTEVVRLLLDSGINAHVRNTYSQTAL 258
A G+TEVV LLLD N R T L
Sbjct: 1259 ACFQGRTEVVSLLLDRKANVEHRAKTGLTPL 1289
Score = 94.4 bits (233), Expect = 7e-19
Identities = 74/225 (32%), Positives = 113/225 (50%), Gaps = 11/225 (4%)
Query: 39 KINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPM 98
K +VN Q G +AL +A G +++ +LLE+ A+++ + G PL A G E
Sbjct: 324 KADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVA 383
Query: 99 KLVLKAGSAVNIPSDE-GHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACE 157
+L+L+ G+ +N S+E L LA GH ++ LL+ ++ + T L AC
Sbjct: 384 RLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACM 443
Query: 158 FGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINR 217
G V V +LLL S + P D+ + SPL LAA GH+++ LL++ G +
Sbjct: 444 DGHVEVARLLLDSGAQVNM----PADSFE----SPLTLAACGGHVELAALLIERGASLEE 495
Query: 218 QTKSG-TALHEAALCGKTEVVRLLLDSGINAHVRNTYSQ-TALDI 260
G T L EAA G E+V LLL G N + + +Q TAL +
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTL 540
Score = 93.2 bits (230), Expect = 2e-18
Identities = 72/235 (30%), Positives = 112/235 (47%), Gaps = 13/235 (5%)
Query: 51 SALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNI 110
SAL A G+ E++ LLEA A + K ++ L A G E +L+L +G+ VN+
Sbjct: 403 SALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNM 462
Query: 111 PSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSS 170
P+D PL LAA GH +++ +L++ ++ V++ G TPL A G +V LLL
Sbjct: 463 PADSFESPLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQ 522
Query: 171 NMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSGTALHEAAL 230
T+ + L LA G +++ L++AG DI + T L EAA
Sbjct: 523 G-------ANINAQTEETQETALTLACCGGFLEVADFLIKAGADI--ELGCSTPLMEAAQ 573
Query: 231 CGKTEVVRLLLDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQ 285
G E+V+ LL +G N H TAL + ++ +L +A A L+
Sbjct: 574 EGHLELVKYLLAAGANVHATTATGDTAL----TYACENGHTDVADVLLQAGADLE 624
Score = 89.7 bits (221), Expect = 2e-17
Identities = 91/285 (31%), Positives = 131/285 (45%), Gaps = 30/285 (10%)
Query: 5 QELVQAVKAEDVGTAQRLLQRPRPGKAKLLGSTKKINVNFQDPDGFSALHHAALNGNTEL 64
+ L +A DV ++LL R +VN +G S L A G EL
Sbjct: 236 RSLAEACSEGDVNAVRKLLIEGR-------------SVNEHTEEGESLLCLACSAGYYEL 282
Query: 65 ISLLLEAQAAVDIKDNKG-MRPLHYAAWQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAA 123
+LL A V+ + KG + PL AA G + +KL+L + VN S G+ L A
Sbjct: 283 AQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYAC 342
Query: 124 QHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGD 183
G+ DV ++LL+ ++ + +G TPL A G V V +L LLE G
Sbjct: 343 AGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARL---------LLENGAGI 393
Query: 184 ATDPN--GTSPLHLAAKNGHIDIIRLLLQAGIDINRQT-KSGTALHEAALCGKTEVVRLL 240
T N S L LA GH++++R LL+AG D +T + TAL EA + G EV RLL
Sbjct: 394 NTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Query: 241 LDSGINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQ 285
LDSG ++ ++ L + E+ LL E A+L+
Sbjct: 454 LDSGAQVNMPADSFESPLTL----AACGGHVELAALLIERGASLE 494
Score = 87.0 bits (214), Expect = 1e-16
Identities = 72/213 (33%), Positives = 102/213 (47%), Gaps = 12/213 (5%)
Query: 31 AKLLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAA 90
A LLG IN ++ +AL A G E+ L++A A +++ + PL AA
Sbjct: 517 ALLLGQGANINAQTEETQE-TALTLACCGGFLEVADFLIKAGADIELGCST---PLMEAA 572
Query: 91 WQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKT 150
+G E +K +L AG+ V+ + G L A ++GH DV+++LLQ ++ G+T
Sbjct: 573 QEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRT 632
Query: 151 PLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQ 210
PL A G V VQ L+S T N + L LA GH+ ++ LLL
Sbjct: 633 PLMKAARAGHVCTVQFLISKG-------ANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 211 AGIDINRQTKSG-TALHEAALCGKTEVVRLLLD 242
G D + K G T L EAA G T VV LLD
Sbjct: 686 HGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
Score = 81.3 bits (199), Expect = 6e-15
Identities = 68/214 (31%), Positives = 105/214 (49%), Gaps = 14/214 (6%)
Query: 33 LLGSTKKINVNFQDPDGFSALHHAALNGNTELISLLLEAQAAVD--IKDNKGMRPLHYAA 90
LL + +IN G S L AA+NG+T + LLL+ + ++ I+ N+ L A
Sbjct: 1202 LLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTA-LTLAC 1260
Query: 91 WQGRKEPMKLVLKAGSAVNIPSDEGHIPLHLAAQHGHYDVSEMLLQHQS--NPCMVDNSG 148
+QGR E + L+L + V + G PL AA G+ +V +LL + N V +S
Sbjct: 1261 FQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSR 1320
Query: 149 KTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLL 208
T L +A + G +LL+ D + G +PL LAA GH+D+++LL
Sbjct: 1321 DTALTIAADKGHYKFCELLIGRGAHI--------DVRNKKGNTPLWLAANGGHLDVVQLL 1372
Query: 209 LQAGIDIN-RQTKSGTALHEAALCGKTEVVRLLL 241
+QAG D++ + T L A G +VVR L+
Sbjct: 1373 VQAGADVDAADNRKITPLMAAFRKGHVKVVRYLV 1406
Score = 80.1 bits (196), Expect = 1e-14
Identities = 54/162 (33%), Positives = 83/162 (51%), Gaps = 10/162 (6%)
Query: 51 SALHHAALNGNTELISLLLEAQAAVDIKDNKGMRPLHYAAWQGRKEPMKLVLKAGSAVNI 110
+AL A G TE++SLLL+ +A V+ + G+ PL AA G E +++L G+ VN
Sbjct: 1254 TALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNA 1313
Query: 111 P--SDEGHIPLHLAAQHGHYDVSEMLLQHQSNPCMVDNSGKTPLDLACEFGRVGVVQLLL 168
P L +AA GHY E+L+ ++ + + G TPL LA G + VVQLL+
Sbjct: 1314 PPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLV 1373
Query: 169 SSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDIIRLLLQ 210
+ DA D +PL A + GH+ ++R L++
Sbjct: 1374 QAGADV--------DAADNRKITPLMAAFRKGHVKVVRYLVK 1407
Score = 59.3 bits (142), Expect = 3e-08
Identities = 44/118 (37%), Positives = 58/118 (49%), Gaps = 10/118 (8%)
Query: 145 DNSGKTPLDLACEFGRVGVVQLLLSSNMCAALLEPRPGDATDPNGTSPLHLAAKNGHIDI 204
+++ T L LAC G +VQ LL A +E R D G +PL LAA GH+ +
Sbjct: 1080 ESNHDTALTLACAGGHEELVQTLLERG---ASIEHR-----DKKGFTPLILAATAGHVGV 1131
Query: 205 IRLLLQAGIDINRQTK--SGTALHEAALCGKTEVVRLLLDSGINAHVRNTYSQTALDI 260
+ +LL G DI Q++ T L A G+ EVV LLL G N RN T L +
Sbjct: 1132 VEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSL 1189
Score = 48.1 bits (113), Expect = 6e-05
Identities = 34/109 (31%), Positives = 51/109 (46%), Gaps = 4/109 (3%)
Query: 185 TDPNGTSPLHLAAKNGHIDIIRLLLQAGIDINRQTKSG-TALHEAALCGKTEVVRLLLDS 243
T+ N + L LA GH ++++ LL+ G I + K G T L AA G VV +LLD+
Sbjct: 1079 TESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDN 1138
Query: 244 GINAHVRNTYSQTALDIVHQFTTSQASREIKQLLREASAALQVRATKDY 292
G + + S+ D S +E+ +LL A + R DY
Sbjct: 1139 GADIEAQ---SERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDY 1184
Score = 43.9 bits (102), Expect = 0.001
Identities = 43/165 (26%), Positives = 58/165 (35%), Gaps = 15/165 (9%)
Query: 1181 PASEQAGPPELPPPP-PPAEP------PPTDLAHLPPLPPPEGEARKPAKPPVSPKPVLT 1233
P +++ P P P PPA+P P D P ++ PPV
Sbjct: 2032 PTAKEHYPVSSPSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTR 2091
Query: 1234 QP-VPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVSPKPPPPPTAPKPVKAVAGLPS 1292
P GS + S + PG S E + PP+ PPP V +A +
Sbjct: 2092 PPNSSSSSGSSSAHSNQQQPPGSVSQEPR------PPLQQSQVPPPEVRMTVPPLATSSA 2145
Query: 1293 GSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSPGAPALH 1337
A PS AP P + P T P + +PP G A H
Sbjct: 2146 PVAVPSTAPVTYPMPQTPMGCPQPT-PKMETPAIRPPPHGTTAPH 2189
Score = 43.1 bits (100), Expect = 0.002
Identities = 38/148 (25%), Positives = 51/148 (34%), Gaps = 14/148 (9%)
Query: 1212 PPPEGEARKPAKPPVSPKPVLTQPVPKLQGSPTPTSKKVPLPGPGSPEVKRAHGTPPPVS 1271
P P + P P SP P QP + SP P S E + G+PP V
Sbjct: 2030 PMPTAKEHYPVSSPSSPSPP-AQPGGVSRNSPLDCGSASPNKVASSSEQEA--GSPPVVE 2086
Query: 1272 PKPPPPPTAPKPVKAVAGLPSGSAGPSPAPSPARQPPAALAKPPGTPPSLGASPAKPPSP 1331
PP + S S+G S A S +QPP ++++ P P P
Sbjct: 2087 TTNTRPPNS-----------SSSSGSSSAHSNQQQPPGSVSQEPRPPLQQSQVPPPEVRM 2135
Query: 1332 GAPALHVPAKPPRAAAAAAAAAAAPPAP 1359
P L + P + A P P
Sbjct: 2136 TVPPLATSSAPVAVPSTAPVTYPMPQTP 2163
Score = 33.5 bits (75), Expect = 1.5
Identities = 34/145 (23%), Positives = 51/145 (35%), Gaps = 12/145 (8%)
Query: 678 PSSHLPPTPRATTRQDSSL---GGRARHMSSSQELLGDGPPGPSSPMSRSQEYLLDEGPA 734
PSS PP ++S L ++SS E PP + +R G +
Sbjct: 2043 PSSPSPPAQPGGVSRNSPLDCGSASPNKVASSSEQEAGSPPVVETTNTRPPNSSSSSGSS 2102
Query: 735 PGTPPREARPGRHGHSIKRASVPPVPGKPRQVLPPGTSHFTPPQTPTKTRPGSPQALGGP 794
++ PG S P P + +PP T P T + P + +
Sbjct: 2103 SAHSNQQQPPGS-------VSQEPRPPLQQSQVPPPEVRMTVPPLATSSAPVAVPSTAPV 2155
Query: 795 HGPAPATAK--VKPTPQLLPPTERP 817
P P T +PTP++ P RP
Sbjct: 2156 TYPMPQTPMGCPQPTPKMETPAIRP 2180
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.131 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 80,970,876
Number of Sequences: 37866
Number of extensions: 6122623
Number of successful extensions: 133707
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1558
Number of HSP's successfully gapped in prelim test: 2898
Number of HSP's that attempted gapping in prelim test: 30155
Number of HSP's gapped (non-prelim): 44941
length of query: 1431
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1316
effective length of database: 13,892,928
effective search space: 18283093248
effective search space used: 18283093248
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.