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Search of human proteins with 170784846
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
(586 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|170784846 kelch-like 7 isoform 1 [Homo sapiens] 1199 0.0
gi|170784844 kelch-like 7 isoform 2 [Homo sapiens] 1125 0.0
gi|166235129 kelch-like 3 [Homo sapiens] 312 5e-85
gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens] 311 1e-84
gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens] 311 1e-84
gi|38194229 kelch-like 17 [Homo sapiens] 306 3e-83
gi|55925604 kelch-like 18 [Homo sapiens] 301 1e-81
gi|40807500 kelch-like 20 [Homo sapiens] 299 4e-81
gi|11056006 kelch-like 12 [Homo sapiens] 293 2e-79
gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens] 275 6e-74
gi|55770880 kelch-like 5 isoform 3 [Homo sapiens] 268 8e-72
gi|65289292 kelch-like 5 isoform 1 [Homo sapiens] 268 8e-72
gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens] 267 2e-71
gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens] 267 2e-71
gi|17017982 kelch-like 4 isoform 1 [Homo sapiens] 265 7e-71
gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens] 265 9e-71
gi|14780904 kelch-like 1 protein [Homo sapiens] 264 2e-70
gi|17017980 kelch-like 4 isoform 2 [Homo sapiens] 263 4e-70
gi|5174473 intracisternal A particle-promoted polypeptide isofor... 247 2e-65
gi|34101268 kelch-like 8 [Homo sapiens] 243 5e-64
gi|223890235 intracisternal A particle-promoted polypeptide isof... 240 3e-63
gi|65289632 kelch-like 5 isoform 2 [Homo sapiens] 239 5e-63
gi|148664209 kelch-like 10 [Homo sapiens] 238 1e-62
gi|40018614 DRE1 protein [Homo sapiens] 220 3e-57
gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens] 211 1e-54
gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain contai... 211 1e-54
gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo... 210 3e-54
gi|8922854 kelch-like 26 [Homo sapiens] 208 1e-53
gi|109150407 kelch-like 6 [Homo sapiens] 201 2e-51
gi|45643138 kelch-like 13 [Homo sapiens] 198 1e-50
>gi|170784846 kelch-like 7 isoform 1 [Homo sapiens]
Length = 586
Score = 1199 bits (3101), Expect = 0.0
Identities = 586/586 (100%), Positives = 586/586 (100%)
Query: 1 MAASGVEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRV 60
MAASGVEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRV
Sbjct: 1 MAASGVEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRV 60
Query: 61 VLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDA 120
VLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDA
Sbjct: 61 VLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDA 120
Query: 121 ANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTD 180
ANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTD
Sbjct: 121 ANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTD 180
Query: 181 EFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISK 240
EFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISK
Sbjct: 181 EFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISK 240
Query: 241 NFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGG 300
NFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGG
Sbjct: 241 NFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGG 300
Query: 301 SQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKD 360
SQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKD
Sbjct: 301 SQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVVKD 360
Query: 361 SWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQR 420
SWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQR
Sbjct: 361 SWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQR 420
Query: 421 CSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVK 480
CSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVK
Sbjct: 421 CSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVK 480
Query: 481 DKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVG 540
DKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVG
Sbjct: 481 DKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVG 540
Query: 541 RLGHILEYNTETDKWVANSKVRAFPVTSCLICVVDTCGANEETLET 586
RLGHILEYNTETDKWVANSKVRAFPVTSCLICVVDTCGANEETLET
Sbjct: 541 RLGHILEYNTETDKWVANSKVRAFPVTSCLICVVDTCGANEETLET 586
>gi|170784844 kelch-like 7 isoform 2 [Homo sapiens]
Length = 564
Score = 1125 bits (2911), Expect = 0.0
Identities = 546/552 (98%), Positives = 550/552 (99%)
Query: 35 NNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 94
+++ +KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI
Sbjct: 13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI 72
Query: 95 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 154
IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE
Sbjct: 73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAE 132
Query: 155 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 214
CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW
Sbjct: 133 CLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 192
Query: 215 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 274
LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP
Sbjct: 193 LKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSP 252
Query: 275 EDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFW 334
EDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFW
Sbjct: 253 EDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFW 312
Query: 335 DNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 394
DNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN
Sbjct: 313 DNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGN 372
Query: 395 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 454
SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY
Sbjct: 373 SALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVY 432
Query: 455 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 514
DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM
Sbjct: 433 DPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 492
Query: 515 PWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICVV 574
PWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICVV
Sbjct: 493 PWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICVV 552
Query: 575 DTCGANEETLET 586
DTCGANEETLET
Sbjct: 553 DTCGANEETLET 564
>gi|166235129 kelch-like 3 [Homo sapiens]
Length = 587
Score = 312 bits (800), Expect = 5e-85
Identities = 185/530 (34%), Positives = 285/530 (53%), Gaps = 11/530 (2%)
Query: 33 VMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEP 92
VMN +R ++ LCDV+++ ++ +I AHRVVLAA S +F MFT +M ESK+ ++E+KD +
Sbjct: 39 VMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDG 98
Query: 93 DIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVL 152
+ +L+++ YTA I V NVQ LL AA+ Q+ V++ C DFL+ Q+ +NCLGI
Sbjct: 99 QTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQNCCDFLQSQLHPTNCLGIRAF 158
Query: 153 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAV 212
A+ C +L A+ + QHF EV +EFL L + +V L++ D LTV +E++V++A +
Sbjct: 159 ADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVI 218
Query: 213 RWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLL 272
W+ Y++ R M ++ VR PL+ +++L +TV+ E LI++N C +I M+YHLL
Sbjct: 219 SWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYHLL 278
Query: 273 SPEDREELVDG--TRPRRKKHDYRIAL-FGGSQPQSCRYFNPKDYS---WTDIRCPFEKR 326
P D+ L+ T+PR ++ + GG P++ R D+ W I +R
Sbjct: 279 -PLDQRLLIKNPRTKPRTPVSLPKVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRR 337
Query: 327 RDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIY 385
A VF VY +GG + ++ +D Y+ VKD W S R +L A +Y
Sbjct: 338 CRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQWTSIASMQERRSTLGAAVLNDLLY 397
Query: 386 TSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSG 445
GG + G++ L E Y +T W M T+R S G+ G +Y GG G S
Sbjct: 398 AVGGFD-GSTGLASVEAYSYKTNEWFFVAPMNTRRSSVGVGVVEGKLYAVGGYDG--ASR 454
Query: 446 RVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKL 505
+ L++ E Y+PAT W + M R G+ + +++A GG +G +VE YD
Sbjct: 455 QCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLYATGGHDGPLVRKSVEVYDPGT 514
Query: 506 NEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
N WK V+ M AV ++YV+ G G L + YN TDKW
Sbjct: 515 NTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPVTDKW 564
Score = 36.2 bits (82), Expect = 0.086
Identities = 18/76 (23%), Positives = 34/76 (44%)
Query: 482 KIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGR 541
K+ V G + +VE YD + + W ++ +P + + VY + GF G R
Sbjct: 301 KVMIVVGGQAPKAIRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLR 360
Query: 542 LGHILEYNTETDKWVA 557
+ + Y+ D+W +
Sbjct: 361 VRTVDVYDGVKDQWTS 376
>gi|239835722 kelch-like 2, Mayven isoform 2 [Homo sapiens]
Length = 597
Score = 311 bits (797), Expect = 1e-84
Identities = 180/550 (32%), Positives = 292/550 (53%), Gaps = 11/550 (2%)
Query: 33 VMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEP 92
VMN +R Q LCDV ++ ++ +I AHRVVLAA S +F+ MFT M ES++ V +K+ +
Sbjct: 49 VMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDG 108
Query: 93 DIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVL 152
+ L+++ YTA I V NVQ LL AA Q++ VKK C +FL+ Q+ NCLGI
Sbjct: 109 WTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 168
Query: 153 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAV 212
A+ C +L A+ + QHF +V ++EFL L +++V L++ D LT+ +E++V++A +
Sbjct: 169 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 228
Query: 213 RWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLL 272
W+ +D+ RQ FM ++ VR PL+ + +L + V+ E L++++ C +I M+YHLL
Sbjct: 229 AWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL 288
Query: 273 SPEDREELVDGTRPRRK---KHDYRIALFGGSQPQSCR---YFNPKDYSWTDIRCPFEKR 326
P ++ L+ R R + + + GG P++ R ++ K+ W + +R
Sbjct: 289 -PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRR 347
Query: 327 RDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIY 385
A V+ +V+ +GG + ++ +D Y+ VKD W S R +L A G +Y
Sbjct: 348 CRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLY 407
Query: 386 TSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSG 445
GG + G++ L E Y+ ++ W M T+R S G+ GL+Y GG G S
Sbjct: 408 AVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG--ASR 464
Query: 446 RVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKL 505
+ L++ E Y+ T WT + M R G+ + + ++AVGG +G +VE YD
Sbjct: 465 QCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTT 524
Query: 506 NEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFP 565
N W+ V+ M AV ++YV+ G G L + YN TDKW S +
Sbjct: 525 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTG 584
Query: 566 VTSCLICVVD 575
+ + V+D
Sbjct: 585 RSYAGVTVID 594
Score = 63.5 bits (153), Expect = 5e-10
Identities = 53/195 (27%), Positives = 79/195 (40%), Gaps = 11/195 (5%)
Query: 293 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 347
Y + F GS S +N K W + P RR + V ++Y +GG +
Sbjct: 407 YAVGGFDGSTGLSSVEAYNIKSNEWFHV-APMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 465
Query: 348 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 407
+ ++CYN + W T R +Y GG + G E YD T
Sbjct: 466 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRKSVEVYDPTT 524
Query: 408 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 467
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT +
Sbjct: 525 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPTTDKWTVVSSC 580
Query: 468 IEARKNHGLVFVKDK 482
+ +++ V V DK
Sbjct: 581 MSTGRSYAGVTVIDK 595
>gi|239835720 kelch-like 2, Mayven isoform 1 [Homo sapiens]
Length = 593
Score = 311 bits (797), Expect = 1e-84
Identities = 180/550 (32%), Positives = 292/550 (53%), Gaps = 11/550 (2%)
Query: 33 VMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEP 92
VMN +R Q LCDV ++ ++ +I AHRVVLAA S +F+ MFT M ES++ V +K+ +
Sbjct: 45 VMNELRSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDG 104
Query: 93 DIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVL 152
+ L+++ YTA I V NVQ LL AA Q++ VKK C +FL+ Q+ NCLGI
Sbjct: 105 WTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAF 164
Query: 153 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAV 212
A+ C +L A+ + QHF +V ++EFL L +++V L++ D LT+ +E++V++A +
Sbjct: 165 ADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVI 224
Query: 213 RWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLL 272
W+ +D+ RQ FM ++ VR PL+ + +L + V+ E L++++ C +I M+YHLL
Sbjct: 225 AWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLL 284
Query: 273 SPEDREELVDGTRPRRK---KHDYRIALFGGSQPQSCR---YFNPKDYSWTDIRCPFEKR 326
P ++ L+ R R + + + GG P++ R ++ K+ W + +R
Sbjct: 285 -PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRR 343
Query: 327 RDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIY 385
A V+ +V+ +GG + ++ +D Y+ VKD W S R +L A G +Y
Sbjct: 344 CRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLY 403
Query: 386 TSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSG 445
GG + G++ L E Y+ ++ W M T+R S G+ GL+Y GG G S
Sbjct: 404 AVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDG--ASR 460
Query: 446 RVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKL 505
+ L++ E Y+ T WT + M R G+ + + ++AVGG +G +VE YD
Sbjct: 461 QCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTT 520
Query: 506 NEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFP 565
N W+ V+ M AV ++YV+ G G L + YN TDKW S +
Sbjct: 521 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTG 580
Query: 566 VTSCLICVVD 575
+ + V+D
Sbjct: 581 RSYAGVTVID 590
Score = 63.5 bits (153), Expect = 5e-10
Identities = 53/195 (27%), Positives = 79/195 (40%), Gaps = 11/195 (5%)
Query: 293 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 347
Y + F GS S +N K W + P RR + V ++Y +GG +
Sbjct: 403 YAVGGFDGSTGLSSVEAYNIKSNEWFHV-APMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 461
Query: 348 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 407
+ ++CYN + W T R +Y GG + G E YD T
Sbjct: 462 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRKSVEVYDPTT 520
Query: 408 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 467
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT +
Sbjct: 521 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPTTDKWTVVSSC 576
Query: 468 IEARKNHGLVFVKDK 482
+ +++ V V DK
Sbjct: 577 MSTGRSYAGVTVIDK 591
>gi|38194229 kelch-like 17 [Homo sapiens]
Length = 642
Score = 306 bits (785), Expect = 3e-83
Identities = 183/533 (34%), Positives = 288/533 (54%), Gaps = 13/533 (2%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
M+ MR++ LCD++L V ++I AH+VVLA+ S +F+ MFT M ES+ V L D +P
Sbjct: 82 MSRMRQRGLLCDIVLHVAAKEIRAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQ 141
Query: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
++QLV+FAYTA I V NVQ+LL AA+ Q+ V+ C FL Q+D SNCLGI A
Sbjct: 142 ALDQLVQFAYTAEIVVGEGNVQTLLPAASLLQLNGVRDACCKFLLSQLDPSNCLGIRGFA 201
Query: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
+ C +L A ++ QHF +V KT+EF+ L +K+V L++ D+L V +E++VY A +
Sbjct: 202 DAHSCSDLLKAAHRYVLQHFVDVAKTEEFMLLPLKQVLELVSSDSLNVPSEEEVYRAVLS 261
Query: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
W+K+D R+ + ++ VR PL+S++FL V AE L++ +P+C ++I +++HLL
Sbjct: 262 WVKHDVDARRQHVPRLMKCVRLPLLSRDFLLGHVDAESLVRHHPDCKDLLIEALKFHLL- 320
Query: 274 PEDREEL-VDGTRPRRKK--HDYRIALFGGSQ---PQSCRYFNPKDYSWTDIRCPFEKRR 327
PE R L TRPRR + A+ GGS C ++ + W + +R
Sbjct: 321 PEQRGVLGTSRTRPRRCEGAGPVLFAVGGGSLFAIHGDCEAYDTRTDRWHVVASMSTRRA 380
Query: 328 DAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYT 386
N +Y +GG + ++ Y+ V ++W ++ T R L A G +Y+
Sbjct: 381 RVGVAAVGNRLYAVGGYDGTSDLATVESYDPVTNTWQPEVSMGTRRSCLGVAALHGLLYS 440
Query: 387 SGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGR 446
+GG + G S L E YD T +W + +M T+R + +G +Y GG S
Sbjct: 441 AGGYD-GASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGG----YDSSS 495
Query: 447 VLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLN 506
L + E Y+P W+ + M+ R + G+ ++ ++ GG +G L++VE Y K
Sbjct: 496 HLATVEKYEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGNDGTSCLNSVERYSPKAG 555
Query: 507 EWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANS 559
W+ V+PM + T A+ +Y + G G L I +YN T+KWVA S
Sbjct: 556 AWESVAPMNIRRSTHDLVAMDGWLYAVGGNDGSSSLNSIEKYNPRTNKWVAAS 608
Score = 70.9 bits (172), Expect = 3e-12
Identities = 49/186 (26%), Positives = 81/186 (43%), Gaps = 12/186 (6%)
Query: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG----SQLFPIKRMDC 354
G S S ++P +WT + +RR D +Y +GG S L +++
Sbjct: 446 GASCLNSAERYDPLTGTWTSVAAMSTRRRYVRVATLDGNLYAVGGYDSSSHLATVEK--- 502
Query: 355 YNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKP 414
Y + W + R S EG +Y +GG++ G S L E Y + +W +
Sbjct: 503 YEPQVNVWSPVASMLSRRSSAGVAVLEGALYVAGGND-GTSCLNSVERYSPKAGAWESVA 561
Query: 415 SMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNH 474
M +R +H +V +G +Y GG+ G++ LNS E Y+P T W M R +
Sbjct: 562 PMNIRRSTHDLVAMDGWLYAVGGNDGSSS----LNSIEKYNPRTNKWVAASCMFTRRSSV 617
Query: 475 GLVFVK 480
G+ ++
Sbjct: 618 GVAVLE 623
>gi|55925604 kelch-like 18 [Homo sapiens]
Length = 574
Score = 301 bits (770), Expect = 1e-81
Identities = 177/532 (33%), Positives = 273/532 (51%), Gaps = 14/532 (2%)
Query: 32 GVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAE 91
GVM +R+Q LCDV L + + K AHR+VLAA+ +F+ MFT +M+E K E+ ++ +
Sbjct: 26 GVMEEIRRQGKLCDVTLKIGDHKFSAHRIVLAASIPYFHAMFTNDMMECKQDEIVMQGMD 85
Query: 92 PDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISV 151
P +E L+ FAY ++++ NVQSLL A+ Q++ +K C FL+E++ NCLG+
Sbjct: 86 PSALEALINFAYNGNLAIDQQNVQSLLMGASFLQLQSIKDACCTFLRERLHPKNCLGVRQ 145
Query: 152 LAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAA 211
AE + C L A+ FIHQHF EV ++EFL L ++ V L+++D L V++E+QV++AA
Sbjct: 146 FAETMMCAVLYDAANSFIHQHFVEVSMSEEFLALPLEDVLELVSRDELNVKSEEQVFEAA 205
Query: 212 VRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHL 271
+ W++YD R P++ ++L+ +R PL FLS VQ + L++ +C +V YHL
Sbjct: 206 LAWVRYDREQRGPYLPELLSNIRLPLCRPQFLSDRVQQDDLVRCCHKCRDLVDEAKDYHL 265
Query: 272 LSPEDREEL-VDGTRPR--RKKHDYRIALFG----GSQPQSCRYFNPKDYSWTDIRCPFE 324
+ PE R L TRPR A+ G G F+P W R
Sbjct: 266 M-PERRPHLPAFRTRPRCCTSIAGLIYAVGGLNSAGDSLNVVEVFDPIANCWERCRPMTT 324
Query: 325 KRRDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGK 383
R + ++Y +GG + ++ YN D+W + R ++ +G+
Sbjct: 325 ARSRVGVAVVNGLLYAIGGYDGQLRLSTVEAYNPETDTWTRVGSMNSKRSAMGTVVLDGQ 384
Query: 384 IYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNV 443
IY GG + GNS+L E Y T+ W SM + R + G+ G IYV GG G
Sbjct: 385 IYVCGGYD-GNSSLSSVETYSPETDKWTVVTSMSSNRSAAGVTVFEGRIYVSGGHDGL-- 441
Query: 444 SGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDI 503
++ +S E Y+ T TW M+ R HG + K+F GG +G G L E Y
Sbjct: 442 --QIFSSVEHYNHHTATWHPAAGMLNKRCRHGAASLGSKMFVCGGYDGSGFLSIAEMYSS 499
Query: 504 KLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
++W ++ PM + V A +Y + G+ G L + Y+ ETD W
Sbjct: 500 VADQWCLIVPMHTRRSRVSLVASCGRLYAVGGYDGQSNLSSVEMYDPETDCW 551
>gi|40807500 kelch-like 20 [Homo sapiens]
Length = 609
Score = 299 bits (766), Expect = 4e-81
Identities = 183/535 (34%), Positives = 285/535 (53%), Gaps = 22/535 (4%)
Query: 33 VMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEP 92
V+N +RK + LCDV+L+V +KI AHRV+L+A S +F MFT + ES+ EV ++D +
Sbjct: 57 VINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVVIRDIDE 116
Query: 93 DIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVL 152
+E L++FAYT++I+V NVQ+LL AA Q+ +++ C +FLK Q+D SNCLGI
Sbjct: 117 RAMELLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEACCEFLKRQLDPSNCLGIRAF 176
Query: 153 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAV 212
A+ C EL AD F +F EV +++EF+ L ++ +++ D L VR+E+QV++A +
Sbjct: 177 ADTHSCRELLRIADKFTQHNFQEVMESEEFMLLPANQLIDIISSDELNVRSEEQVFNAVM 236
Query: 213 RWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLL 272
W+KY R+P + +L VR PL+S FL TV ++PLI+ + EC +V Y LL
Sbjct: 237 AWVKYSIQERRPQLPQVLQHVRLPLLSPKFLVGTVGSDPLIKSDEECRDLVDEAKNY-LL 295
Query: 273 SPEDREELVDGTRPRRKK----HDYRIALFG---GSQPQSCRYFNPKDYSWTDIRCPFEK 325
P++R L+ G R R +K + A+ G G S ++P+ W + ++
Sbjct: 296 LPQER-PLMQGPRTRPRKPIRCGEVLFAVGGWCSGDAISSVERYDPQTNEWRMVASMSKR 354
Query: 326 RRDAACVFWDNVVYILGG----SQLFPIKRMDCYNVVKDSWYSKLGP-PTPRDSLAACAA 380
R D+++Y +GG S L ++R Y+ + W S + P T R S+
Sbjct: 355 RCGVGVSVLDDLLYAVGGHDGSSYLNSVER---YDPKTNQWSSDVAPTSTCRTSVGVAVL 411
Query: 381 EGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLG 440
G +Y GG + G S L + E YD + W SM T+R + G +Y GGS G
Sbjct: 412 GGFLYAVGGQD-GVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDG 470
Query: 441 NNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEY 500
+ LN+ E Y+P W + PM RK+ G +D I+AVGG++ L + E
Sbjct: 471 TS----PLNTVERYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRDDTTELSSAER 526
Query: 501 YDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
Y+ + N+W V M + V A V + + GF G L I ++ + + W
Sbjct: 527 YNPRTNQWSPVVAMTSRRSGVGLAVVNGQLMAVGGFDGTTYLKTIEVFDPDANTW 581
Score = 68.6 bits (166), Expect = 2e-11
Identities = 50/187 (26%), Positives = 77/187 (41%), Gaps = 10/187 (5%)
Query: 299 GGSQPQSC----RYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMD 353
GG SC ++PK+ WT + +R A +Y +GGS P+ ++
Sbjct: 419 GGQDGVSCLNIVERYDPKENKWTRVASMSTRRLGVAVAVLGGFLYAVGGSDGTSPLNTVE 478
Query: 354 CYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTK 413
YN ++ W++ T R L + IY GG + + L E Y+ RT W
Sbjct: 479 RYNPQENRWHTIAPMGTRRKHLGCAVYQDMIYAVGGRD-DTTELSSAERYNPRTNQWSPV 537
Query: 414 PSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKN 473
+M ++R G+ NG + GG G L + EV+DP TW M R
Sbjct: 538 VAMTSRRSGVGLAVVNGQLMAVGGFDGTTY----LKTIEVFDPDANTWRLYGGMNYRRLG 593
Query: 474 HGLVFVK 480
G+ +K
Sbjct: 594 GGVGVIK 600
>gi|11056006 kelch-like 12 [Homo sapiens]
Length = 568
Score = 293 bits (751), Expect = 2e-79
Identities = 183/533 (34%), Positives = 280/533 (52%), Gaps = 19/533 (3%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
MN++RK TLCDV L V+++ PAHR+VLAA S +F MFT+ + E V+++
Sbjct: 23 MNSLRKSNTLCDVTLRVEQKDFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTAS 82
Query: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
+E L++F YT + V NVQ LL AA Q++ VK+ C +FL+ Q+D SNCLGI A
Sbjct: 83 TMEILLDFVYTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFA 142
Query: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
E +C +L A+ F +HF EV + +EF+ L V L+ D + V +E+ V++A +
Sbjct: 143 ETHNCVDLMQAAEVFSQKHFPEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVIN 202
Query: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
W+K+ + R+ + ++L VR PL++ +++ + AEP I+ + +C +V ++H L
Sbjct: 203 WVKHAKKEREESLPNLLQYVRMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFH-LR 261
Query: 274 PEDREELV-DGTRPRRKKHDYRIALFGGSQPQS----CRYFNPKDYSWTDIRCPFEKRRD 328
PE R ++ TR R ++ + + G QS ++PK W+ + KRR
Sbjct: 262 PELRSQMQGPRTRARLGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRY 321
Query: 329 AACVFWDNVVYILGG----SQLFPIKRMDCYNVVKDS-WYSKLGPPTPRDSLAACAAEG- 382
A V + +Y++GG S+L ++ +D Y +D WYS + P R LA G
Sbjct: 322 VASVSLHDRIYVIGGYDGRSRLSSVECLD-YTADEDGVWYS-VAPMNVRRGLAGATTLGD 379
Query: 383 KIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNN 442
IY SGG + G+ E YD + W M T R G+V A+G+IY GG G N
Sbjct: 380 MIYVSGGFD-GSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLN 438
Query: 443 VSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYD 502
+LNS E YDP T WT + PM R G+ + D I+ VGG +G L +VE Y+
Sbjct: 439 ----ILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYN 494
Query: 503 IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
I+ + W V+ M V + +Y +AG+ G L I Y+ D W
Sbjct: 495 IRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAGYDGNSLLSSIECYDPIIDSW 547
Score = 72.4 bits (176), Expect = 1e-12
Identities = 52/185 (28%), Positives = 79/185 (42%), Gaps = 6/185 (3%)
Query: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMDCYNV 357
G + S ++P W+ + R A V V+Y LGG L + ++ Y+
Sbjct: 389 GSRRHTSMERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDP 448
Query: 358 VKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSML 417
W + T R IY GG + G + L E Y+ RT+SW T SM
Sbjct: 449 HTGHWTNVTPMATKRSGAGVALLNDHIYVVGGFD-GTAHLSSVEAYNIRTDSWTTVTSMT 507
Query: 418 TQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLV 477
T RC G G +Y G GN++ L+S E YDP ++W + M R + G+
Sbjct: 508 TPRCYVGATVLRGRLYAIAGYDGNSL----LSSIECYDPIIDSWEVVTSMGTQRCDAGVC 563
Query: 478 FVKDK 482
+++K
Sbjct: 564 VLREK 568
>gi|44680141 BTB (POZ) domain containing 5 [Homo sapiens]
Length = 571
Score = 275 bits (704), Expect = 6e-74
Identities = 173/539 (32%), Positives = 274/539 (50%), Gaps = 25/539 (4%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
+N +R+ LCD+IL V + KI AH+VVLA+ S +F MFT N+ E ++ EVE + +
Sbjct: 25 LNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTGNLSEKENSEVEFQCIDET 84
Query: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
++ +VE+AYT + ++ + V+SLL AAN QI+ V K C FL+ Q+D NC+GIS A
Sbjct: 85 ALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLDPGNCIGISRFA 144
Query: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
E C +L A +I Q+F V +T+EF +L + +++ D L V E+ V+ A
Sbjct: 145 ETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETVFYALES 204
Query: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
W+KYD RQ ++ +L VR PL+S FL++ +A LI+D+ C ++ ++YH +
Sbjct: 205 WIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFM- 263
Query: 274 PEDR--EELVDGTRPRRKKHDYRIALFGGSQP-----QSCRYFNPKDYSWTDIRCPFEKR 326
PE R + V TRPR + GG S + P++ SW + R
Sbjct: 264 PEHRLSHQTVLMTRPRCAPK--VLCAVGGKSGLFACLDSVEMYFPQNDSWIGLAPLNIPR 321
Query: 327 RDAACVFWDNVVYILGG--SQLFP---IKR----MDCYNVVKDSWYSKLGPPTPRDSLAA 377
+ D VY++GG + + P I++ ++C+N ++W S R +L
Sbjct: 322 YEFGICVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNPDTNTWTSLERMNESRSTLGV 381
Query: 378 CAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGG 437
G++Y GG + G S L E Y + W M T R +G+IY GG
Sbjct: 382 VVLAGELYALGGYD-GQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGG 440
Query: 438 SLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDN 497
+NS E YDP+ ++W + M + R + G+ + IF VGG NG+ L +
Sbjct: 441 -----YGPAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVSHLSS 495
Query: 498 VEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWV 556
+E YD N+W + PM V A + + +YV+ G G L + +Y+ +D W+
Sbjct: 496 IERYDPHQNQWTVCRPMKEPRTGVGAAVIDNYLYVVGGHSGSSYLNTVQKYDPISDTWL 554
Score = 68.2 bits (165), Expect = 2e-11
Identities = 51/178 (28%), Positives = 70/178 (39%), Gaps = 5/178 (2%)
Query: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDCYNVV 358
G S QS + PK W + R A D ++Y +GG + ++ Y+
Sbjct: 396 GQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGYGPAHMNSVERYDPS 455
Query: 359 KDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLT 418
KDSW R G I+ GG G S L E YD W M
Sbjct: 456 KDSWEMVASMADKRIHFGVGVMLGFIFVVGGHN-GVSHLSSIERYDPHQNQWTVCRPMKE 514
Query: 419 QRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGL 476
R G + +YV GG G++ LN+ + YDP ++TW + MI R N GL
Sbjct: 515 PRTGVGAAVIDNYLYVVGGHSGSSY----LNTVQKYDPISDTWLDSAGMIYCRCNFGL 568
>gi|55770880 kelch-like 5 isoform 3 [Homo sapiens]
Length = 709
Score = 268 bits (686), Expect = 8e-72
Identities = 161/537 (29%), Positives = 268/537 (49%), Gaps = 61/537 (11%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
M N + K LCDVIL+ +R+IPAHR+VL++ S +F MFT ++ E++ E++++ EP+
Sbjct: 164 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 223
Query: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
+ L+++AYT R+ + +N++ LL A Q+ V + C FL +Q+ SNCLGI A
Sbjct: 224 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 283
Query: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
+ C +L A ++ +HF EV + EF+ L + LL D + + E+ + +A +
Sbjct: 284 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 343
Query: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
W+++D R+ + +LA +R PL++ FL+ ++ L +D+ EC K+++ M+YHLL
Sbjct: 344 WVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLL- 401
Query: 274 PEDREELVD-GTRPRRKKHDYRIALFGGSQPQ---SCRYFNPKDYSWTDIRCPFEKRRDA 329
PE R L T+PR+ A+ G + S ++ + WT + +R
Sbjct: 402 PERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF 461
Query: 330 ACVFWDNVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPP------------------- 369
D+ +Y++GG L + ++CYN +W + PP
Sbjct: 462 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTW--SVMPPMSTHRHGLGVAVLEGPMYA 519
Query: 370 ------------------------------TPRDSLAACAAEGKIYTSGGSEVGNSALYL 399
TPR ++ GK+Y GG + G+S L
Sbjct: 520 VGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKS 578
Query: 400 FECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGG--SLGNNVSGRVLNSCEVYDPA 457
EC+D T W M +R G+ NGL+Y GG + +N++ R+ + E YDP
Sbjct: 579 VECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPK 638
Query: 458 TETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 514
T+ WT + M +R G+ + DK++AVGG +G L+ VE YD + NEW V+P+
Sbjct: 639 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 695
>gi|65289292 kelch-like 5 isoform 1 [Homo sapiens]
Length = 755
Score = 268 bits (686), Expect = 8e-72
Identities = 161/537 (29%), Positives = 268/537 (49%), Gaps = 61/537 (11%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
M N + K LCDVIL+ +R+IPAHR+VL++ S +F MFT ++ E++ E++++ EP+
Sbjct: 210 MENYLRHKQLCDVILVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPN 269
Query: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
+ L+++AYT R+ + +N++ LL A Q+ V + C FL +Q+ SNCLGI A
Sbjct: 270 SLWSLIQYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFA 329
Query: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
+ C +L A ++ +HF EV + EF+ L + LL D + + E+ + +A +
Sbjct: 330 DAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLLPASEIAKLLASDDMNIPNEETILNALLT 389
Query: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
W+++D R+ + +LA +R PL++ FL+ ++ L +D+ EC K+++ M+YHLL
Sbjct: 390 WVRHDLEQRRKDLSKLLAYIRLPLLAPQFLA-DMENNVLFRDDIECQKLIMEAMKYHLL- 447
Query: 274 PEDREELVD-GTRPRRKKHDYRIALFGGSQPQ---SCRYFNPKDYSWTDIRCPFEKRRDA 329
PE R L T+PR+ A+ G + S ++ + WT + +R
Sbjct: 448 PERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQF 507
Query: 330 ACVFWDNVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPP------------------- 369
D+ +Y++GG L + ++CYN +W + PP
Sbjct: 508 GVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTW--SVMPPMSTHRHGLGVAVLEGPMYA 565
Query: 370 ------------------------------TPRDSLAACAAEGKIYTSGGSEVGNSALYL 399
TPR ++ GK+Y GG + G+S L
Sbjct: 566 VGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKS 624
Query: 400 FECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGG--SLGNNVSGRVLNSCEVYDPA 457
EC+D T W M +R G+ NGL+Y GG + +N++ R+ + E YDP
Sbjct: 625 VECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPK 684
Query: 458 TETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 514
T+ WT + M +R G+ + DK++AVGG +G L+ VE YD + NEW V+P+
Sbjct: 685 TDMWTAVASMSISRDAVGVCLLGDKLYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 741
>gi|45269145 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 267 bits (683), Expect = 2e-71
Identities = 173/540 (32%), Positives = 268/540 (49%), Gaps = 29/540 (5%)
Query: 32 GVMNNMRKQKTLCDVILMVQERKIPA-----HRVVLAAASHFFNLMFTTNMLESKSFEVE 86
G+MN +R + LCDV L V+ + PA H+VVLA++S F MFT + E V
Sbjct: 65 GIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVS 124
Query: 87 LKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNC 146
++ P ++E+L+EFAYTA IS+ V +++ A YQI+ V + C DFL +Q+D SN
Sbjct: 125 IEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNA 184
Query: 147 LGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 206
+GI+ AE + C EL A ++I+ HF EV K +EF L ++ L+++D L VR E +
Sbjct: 185 IGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESE 244
Query: 207 VYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISG 266
V+ A + W+KYD R+ ++ +L VR ++ NFL +Q ++Q + C ++
Sbjct: 245 VFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVK- 303
Query: 267 MRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRY---FNPKDYSW---TDIR 320
+ L+ +++ P+ + Y GG QS Y +NP D +W D++
Sbjct: 304 -IFEELTLHKPTQVMPCRAPKVGRLIYTA---GGYFRQSLSYLEAYNPSDGTWLRLADLQ 359
Query: 321 CPFEKRRDAACVFWDNVVYILGGSQLFP-----IKRMDCYNVVKDSWYSKLGPPTPRDSL 375
P + A CV ++Y +GG P +DCYN + + W PR+ +
Sbjct: 360 VP--RSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRI 416
Query: 376 AACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVC 435
+G IY GGS G E Y+ + WH MLT+R G+ N L+Y
Sbjct: 417 GVGVIDGHIYAVGGSH-GCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV 475
Query: 436 GGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGL 495
GG G N LNS E Y P W + M R G+ + + I+A GG +G L
Sbjct: 476 GGFDGTN----RLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
Query: 496 DNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
++VE YD++ W V+PM + + +YVL G+ G L + Y+ +TD W
Sbjct: 532 NSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
Score = 71.6 bits (174), Expect = 2e-12
Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 10/190 (5%)
Query: 292 DYRIALFGGSQP----QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-L 346
D I GGS S + P+ W + +R + ++Y +GG
Sbjct: 422 DGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGT 481
Query: 347 FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTR 406
+ +CY ++ W T R C IY +GG + G L E YD
Sbjct: 482 NRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD-GQDQLNSVERYDVE 540
Query: 407 TESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 466
TE+W M +R + G+ G IYV GG G+ L+S E YDP T+TW+E+
Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF----LDSVECYDPDTDTWSEVTR 596
Query: 467 MIEARKNHGL 476
M R G+
Sbjct: 597 MTSGRSGVGV 606
>gi|22027642 kelch-like ECH-associated protein 1 [Homo sapiens]
Length = 624
Score = 267 bits (683), Expect = 2e-71
Identities = 173/540 (32%), Positives = 268/540 (49%), Gaps = 29/540 (5%)
Query: 32 GVMNNMRKQKTLCDVILMVQERKIPA-----HRVVLAAASHFFNLMFTTNMLESKSFEVE 86
G+MN +R + LCDV L V+ + PA H+VVLA++S F MFT + E V
Sbjct: 65 GIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGMEVVS 124
Query: 87 LKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNC 146
++ P ++E+L+EFAYTA IS+ V +++ A YQI+ V + C DFL +Q+D SN
Sbjct: 125 IEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLDPSNA 184
Query: 147 LGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 206
+GI+ AE + C EL A ++I+ HF EV K +EF L ++ L+++D L VR E +
Sbjct: 185 IGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVRCESE 244
Query: 207 VYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISG 266
V+ A + W+KYD R+ ++ +L VR ++ NFL +Q ++Q + C ++
Sbjct: 245 VFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDYLVK- 303
Query: 267 MRYHLLSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRY---FNPKDYSW---TDIR 320
+ L+ +++ P+ + Y GG QS Y +NP D +W D++
Sbjct: 304 -IFEELTLHKPTQVMPCRAPKVGRLIYTA---GGYFRQSLSYLEAYNPSDGTWLRLADLQ 359
Query: 321 CPFEKRRDAACVFWDNVVYILGGSQLFP-----IKRMDCYNVVKDSWYSKLGPPTPRDSL 375
P + A CV ++Y +GG P +DCYN + + W PR+ +
Sbjct: 360 VP--RSGLAGCVV-GGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRI 416
Query: 376 AACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVC 435
+G IY GGS G E Y+ + WH MLT+R G+ N L+Y
Sbjct: 417 GVGVIDGHIYAVGGSH-GCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAV 475
Query: 436 GGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGL 495
GG G N LNS E Y P W + M R G+ + + I+A GG +G L
Sbjct: 476 GGFDGTN----RLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQL 531
Query: 496 DNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
++VE YD++ W V+PM + + +YVL G+ G L + Y+ +TD W
Sbjct: 532 NSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTW 591
Score = 71.6 bits (174), Expect = 2e-12
Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 10/190 (5%)
Query: 292 DYRIALFGGSQP----QSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-L 346
D I GGS S + P+ W + +R + ++Y +GG
Sbjct: 422 DGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDGT 481
Query: 347 FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTR 406
+ +CY ++ W T R C IY +GG + G L E YD
Sbjct: 482 NRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYD-GQDQLNSVERYDVE 540
Query: 407 TESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 466
TE+W M +R + G+ G IYV GG G+ L+S E YDP T+TW+E+
Sbjct: 541 TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTF----LDSVECYDPDTDTWSEVTR 596
Query: 467 MIEARKNHGL 476
M R G+
Sbjct: 597 MTSGRSGVGV 606
>gi|17017982 kelch-like 4 isoform 1 [Homo sapiens]
Length = 718
Score = 265 bits (678), Expect = 7e-71
Identities = 168/551 (30%), Positives = 267/551 (48%), Gaps = 18/551 (3%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
M N K+K LCDV+L+ +IPAHR+VL+A S +F MFT ++LE+K EV ++ +P+
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
+ LV++AYT + + + ++SLL AA Q+ V +C +FL +Q+ SNCLGI
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
+ C EL A + +HF EV K EFL L ++ LL D + V E+ ++ A ++
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
W+ +D NRQ + +L+ +R PL+ L+ ++ + + EC K+++ M+YHLL
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLA-DLETSSMFTGDLECQKLLMEAMKYHLL- 409
Query: 274 PEDREELVDGTRPRRKKHDYRIALFGGSQPQ----SCRYFNPKDYSWTDIRCPFEKRRDA 329
PE R + RK + GG + ++ + SW I +R
Sbjct: 410 PERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
Query: 330 ACVFWDNVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG 388
DN +Y++GG L + ++C+N V W T R L EG +Y G
Sbjct: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
Query: 389 GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL 448
G + G S L E +D W+ SM T R + G+V N +Y GG G++ L
Sbjct: 530 GHD-GWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS----CL 584
Query: 449 NSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYD 502
S E +DP T W+ PM + R G+ ++ VGG + D VE YD
Sbjct: 585 KSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYD 644
Query: 503 IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVR 562
K + W V+P+ V +G +YV+ G+ G L + Y+ + ++W V
Sbjct: 645 PKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEWKEEVPVN 704
Query: 563 AFPVTSCLICV 573
+C++ V
Sbjct: 705 IGRAGACVVVV 715
>gi|239835724 kelch-like 2, Mayven isoform 3 [Homo sapiens]
Length = 505
Score = 265 bits (677), Expect = 9e-71
Identities = 157/506 (31%), Positives = 261/506 (51%), Gaps = 11/506 (2%)
Query: 77 MLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDF 136
M ES++ V +K+ + + L+++ YTA I V NVQ LL AA Q++ VKK C +F
Sbjct: 1 MSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEF 60
Query: 137 LKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQ 196
L+ Q+ NCLGI A+ C +L A+ + QHF +V ++EFL L +++V L++
Sbjct: 61 LESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISS 120
Query: 197 DTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDN 256
D LT+ +E++V++A + W+ +D+ RQ FM ++ VR PL+ + +L + V+ E L++++
Sbjct: 121 DKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNS 180
Query: 257 PECLKMVISGMRYHLLSPEDREELVDGTRPRRK---KHDYRIALFGGSQPQSCR---YFN 310
C +I M+YHLL P ++ L+ R R + + + GG P++ R ++
Sbjct: 181 SACKDYLIEAMKYHLL-PTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYD 239
Query: 311 PKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG-SQLFPIKRMDCYNVVKDSWYSKLGPP 369
K+ W + +R A V+ +V+ +GG + ++ +D Y+ VKD W S
Sbjct: 240 FKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMR 299
Query: 370 TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEAN 429
R +L A G +Y GG + G++ L E Y+ ++ W M T+R S G+
Sbjct: 300 DRRSTLGAAVLNGLLYAVGGFD-GSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVG 358
Query: 430 GLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQ 489
GL+Y GG G S + L++ E Y+ T WT + M R G+ + + ++AVGG
Sbjct: 359 GLLYAVGGYDG--ASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGH 416
Query: 490 NGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 549
+G +VE YD N W+ V+ M AV ++YV+ G G L + YN
Sbjct: 417 DGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYN 476
Query: 550 TETDKWVANSKVRAFPVTSCLICVVD 575
TDKW S + + + V+D
Sbjct: 477 PTTDKWTVVSSCMSTGRSYAGVTVID 502
Score = 63.5 bits (153), Expect = 5e-10
Identities = 53/195 (27%), Positives = 79/195 (40%), Gaps = 11/195 (5%)
Query: 293 YRIALFGGSQP-QSCRYFNPKDYSWTDIRCPFEKRRDAACV-FWDNVVYILGG---SQLF 347
Y + F GS S +N K W + P RR + V ++Y +GG +
Sbjct: 315 YAVGGFDGSTGLSSVEAYNIKSNEWFHV-APMNTRRSSVGVGVVGGLLYAVGGYDGASRQ 373
Query: 348 PIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 407
+ ++CYN + W T R +Y GG + G E YD T
Sbjct: 374 CLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHD-GPLVRKSVEVYDPTT 432
Query: 408 ESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPM 467
+W M R + G+ NGL+YV GG G+ L S E Y+P T+ WT +
Sbjct: 433 NAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCN----LASVEYYNPTTDKWTVVSSC 488
Query: 468 IEARKNHGLVFVKDK 482
+ +++ V V DK
Sbjct: 489 MSTGRSYAGVTVIDK 503
>gi|14780904 kelch-like 1 protein [Homo sapiens]
Length = 748
Score = 264 bits (674), Expect = 2e-70
Identities = 167/551 (30%), Positives = 274/551 (49%), Gaps = 18/551 (3%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
M + KQ+ LCDVIL+V RKIPAHR+VL++ S +F MFT+++ E+K E++++ +P+
Sbjct: 202 MESYLKQQQLCDVILIVGNRKIPAHRLVLSSVSDYFAAMFTSDVCEAKQEEIKMEGIDPN 261
Query: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
+ LV+FAYT + + + +++LL AA Q+ V ++C FL + + SNCLGI A
Sbjct: 262 ALWDLVQFAYTGCLELKEDTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFA 321
Query: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
+ C EL A + ++ EV + EFL L + + LL D + V E+ ++ A +
Sbjct: 322 DAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMM 381
Query: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
W+KYD +R + +LA +R PL+ L+ ++ L +++ EC K+++ M+YHLL
Sbjct: 382 WVKYDMQSRCNDLSMLLAFIRLPLLPPQILA-DLENHALFKNDLECQKLILEAMKYHLL- 439
Query: 274 PEDREELVD-GTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYS---WTDIRCPFEKRRDA 329
PE R + T+PR+ A+ G + D W +R
Sbjct: 440 PERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGATTIEKYDLRTNLWIQAGMMNGRRLQF 499
Query: 330 ACVFWDNVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG 388
D+ ++++GG L + ++CYN +W T R L EG IY G
Sbjct: 500 GVAVIDDKLFVIGGRDGLKTLNTVECYNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVG 559
Query: 389 GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL 448
G + G S L E +D +++ W SM R + G+ NG +Y GG G++ L
Sbjct: 560 GHD-GWSYLNTVERWDPQSQQWTFVASMSIARSTVGVAALNGKLYSVGGRDGSS----CL 614
Query: 449 NSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYD 502
+S E YDP T W PM + R G+ ++AVGG + LD VE YD
Sbjct: 615 SSMEYYDPHTNKWNMCAPMCKRRGGVGVATCDGFLYAVGGHDAPASNHCSRLLDYVERYD 674
Query: 503 IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVR 562
K + W MV+P+ V +G +Y + G+ G L + Y+ +T++W + +
Sbjct: 675 PKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGGYDGQTYLNTMESYDPQTNEWTQMASLN 734
Query: 563 AFPVTSCLICV 573
+C++ +
Sbjct: 735 IGRAGACVVVI 745
>gi|17017980 kelch-like 4 isoform 2 [Homo sapiens]
Length = 720
Score = 263 bits (671), Expect = 4e-70
Identities = 165/533 (30%), Positives = 261/533 (48%), Gaps = 18/533 (3%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
M N K+K LCDV+L+ +IPAHR+VL+A S +F MFT ++LE+K EV ++ +P+
Sbjct: 172 MENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAMFTNDVLEAKQEEVRMEGVDPN 231
Query: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
+ LV++AYT + + + ++SLL AA Q+ V +C +FL +Q+ SNCLGI
Sbjct: 232 ALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDVCSNFLIKQLHPSNCLGIRSFG 291
Query: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
+ C EL A + +HF EV K EFL L ++ LL D + V E+ ++ A ++
Sbjct: 292 DAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISKLLCSDDINVPDEETIFHALMQ 351
Query: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
W+ +D NRQ + +L+ +R PL+ L+ ++ + + EC K+++ M+YHLL
Sbjct: 352 WVGHDVQNRQGELGMLLSYIRLPLLPPQLLA-DLETSSMFTGDLECQKLLMEAMKYHLL- 409
Query: 274 PEDREELVDGTRPRRKKHDYRIALFGGSQPQ----SCRYFNPKDYSWTDIRCPFEKRRDA 329
PE R + RK + GG + ++ + SW I +R
Sbjct: 410 PERRSMMQSPRTKPRKSTVGALYAVGGMDAMKGTTTIEKYDLRTNSWLHIGTMNGRRLQF 469
Query: 330 ACVFWDNVVYILGGSQ-LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG 388
DN +Y++GG L + ++C+N V W T R L EG +Y G
Sbjct: 470 GVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTVMPPMSTHRHGLGVATLEGPMYAVG 529
Query: 389 GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL 448
G + G S L E +D W+ SM T R + G+V N +Y GG G++ L
Sbjct: 530 GHD-GWSYLNTVERWDPEGRQWNYVASMSTPRSTVGVVALNNKLYAIGGRDGSS----CL 584
Query: 449 NSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGG------LDNVEYYD 502
S E +DP T W+ PM + R G+ ++ VGG + D VE YD
Sbjct: 585 KSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGHDAPASNHCSRLSDCVERYD 644
Query: 503 IKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
K + W V+P+ V +G +YV+ G+ G L + Y+ + ++W
Sbjct: 645 PKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLNTVESYDAQRNEW 697
>gi|5174473 intracisternal A particle-promoted polypeptide isoform 1
[Homo sapiens]
Length = 584
Score = 247 bits (631), Expect = 2e-65
Identities = 174/582 (29%), Positives = 272/582 (46%), Gaps = 61/582 (10%)
Query: 12 KKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNL 71
K + ++ + A+L+ + +N MR + CDV L V + AHR+VLAA+S +F
Sbjct: 8 KAADSPFSSDKHAQLI---LAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAA 64
Query: 72 MFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKK 131
+FT M ES V + E I + L++F YT +++ NNVQ L+ AA+ Q+ V
Sbjct: 65 LFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVH 124
Query: 132 MCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVT 191
+C +FLK Q+D NC+GI +E + C +L ++++IH HF EV+ +EFL L ++
Sbjct: 125 LCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLI 184
Query: 192 HLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQA-- 249
+L + L++ E QV+ AA++W+ D R+ +V++L +RFPL+ L K ++
Sbjct: 185 KILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVS 244
Query: 250 --------EPLIQDNPECLKMVISGMRYHLLSPEDREEL----VDGTRPRRKKHDYRIAL 297
+ L+++ E K SP++ + RPR+K Y A+
Sbjct: 245 DFNLRVALQTLLKEYCEVCK-----------SPKENKFCSFLQTSKVRPRKKARKYLYAV 293
Query: 298 FGGSQPQSCRYFNPKDYS-----------WTDIRCPFEKRRDAACVFWDNVVYILGG--- 343
G ++ Q R+ + + S WT + + R +VY +GG
Sbjct: 294 GGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKD 353
Query: 344 SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG---GSEVGNSALYLF 400
S +F +CY+ V W + PR L C G IY G G+E+GN+
Sbjct: 354 SMIFDC--TECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNT----I 407
Query: 401 ECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATET 460
E +D W +M R G E GLIYV GG + L S EVYDP ++
Sbjct: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIE---LRSFEVYDPLSKR 464
Query: 461 WTELCPMIEARKNHGLVFVKDKIFAVGGQNGL-GGLDNVEYYDIKLNEWKMVSPMPWKGV 519
W+ L PM R G+ + D I++VGG N L VE Y + +W V+ M
Sbjct: 465 WSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRA 524
Query: 520 TVKCAAVGSIVYVLAG------FQGVGRLGHILEYNTETDKW 555
+ AV ++YV G F G L + YN +D W
Sbjct: 525 GMCVVAVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTW 566
Score = 75.5 bits (184), Expect = 1e-13
Identities = 49/172 (28%), Positives = 78/172 (45%), Gaps = 4/172 (2%)
Query: 309 FNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGG--SQLFPIKRMDCYNVVKDSWYSKL 366
F+P + W + R C ++Y++GG ++ ++ + Y+ + W
Sbjct: 410 FDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRWSPLP 469
Query: 367 GPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMV 426
T R L A IY+ GG AL+ E Y E W SM R +V
Sbjct: 470 PMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRAGMCVV 529
Query: 427 EANGLIYVCGGSLGNN--VSGRVLNSCEVYDPATETWTELCPMIEARKNHGL 476
NGL+YV GG ++ ++ L+S EVY+P ++TWTE+ MI +R G+
Sbjct: 530 AVNGLLYVSGGRSSSHDFLAPGTLDSVEVYNPHSDTWTEIGNMITSRCEGGV 581
>gi|34101268 kelch-like 8 [Homo sapiens]
Length = 620
Score = 243 bits (619), Expect = 5e-64
Identities = 154/527 (29%), Positives = 249/527 (47%), Gaps = 46/527 (8%)
Query: 30 FMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKD 89
F G + + LCDV L V + I H++VLA +F MF + M E+K +E++D
Sbjct: 53 FHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRD 112
Query: 90 AEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGI 149
+ D IE LV+F Y++R+++ +NVQ LL AA Q+E V + C +++K SNCL +
Sbjct: 113 FDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAV 172
Query: 150 SVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYD 209
AE + +L AD + HFTEV + ++F+ + + + LL+ L + E QVY+
Sbjct: 173 RAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYN 232
Query: 210 AAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRY 269
AA++WL + + ++ + LA+VR PL+ +FL V E +++ N +C ++ Y
Sbjct: 233 AAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNY 292
Query: 270 HL-LSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRD 328
HL LS + R +KH + G +
Sbjct: 293 HLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGR-------------------------- 326
Query: 329 AACVFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG 388
GGS P + ++CY++ K+SW+ + R + + EGK+Y G
Sbjct: 327 -------------GGSG-DPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVG 372
Query: 389 GSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL 448
G + GN L E +D T W K SM T+R + G IY GG N
Sbjct: 373 GHD-GNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNT----CF 427
Query: 449 NSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEW 508
N E YD ++ W+ + PM R G V + + ++AVGG +G+ L +VE YD L++W
Sbjct: 428 NDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKW 487
Query: 509 KMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
V M + + + +YV+ GF L + Y+ ++KW
Sbjct: 488 IEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKW 534
Score = 91.7 bits (226), Expect = 2e-18
Identities = 56/187 (29%), Positives = 83/187 (44%), Gaps = 9/187 (4%)
Query: 370 TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEAN 429
TPR A G ++ GG ECY SW P M ++R G++
Sbjct: 311 TPRKHTA-----GVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVE 365
Query: 430 GLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQ 489
G +Y GG GN G S E++DP T W M R+ L + I+A+GG
Sbjct: 366 GKVYAVGGHDGNEHLG----SMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGL 421
Query: 490 NGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYN 549
+ ++VE YDI+ ++W V+PM V A+ + VY + G G+ L + Y+
Sbjct: 422 DDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYD 481
Query: 550 TETDKWV 556
DKW+
Sbjct: 482 PHLDKWI 488
Score = 52.8 bits (125), Expect = 9e-07
Identities = 48/188 (25%), Positives = 70/188 (37%), Gaps = 12/188 (6%)
Query: 295 IALFGGSQPQSC-----RYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFP 348
I GG +C RY D W+ + R V N VY +GG+ +
Sbjct: 415 IYAIGGLDDNTCFNDVERYDIESD-QWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMAS 473
Query: 349 IKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTE 408
+ ++ Y+ D W R G +Y GG + NS L E YD R+
Sbjct: 474 LSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFD-DNSPLSSVERYDPRSN 532
Query: 409 SWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMI 468
W ++ T R G+ G I+ GG GN LN+ E +DP W + +
Sbjct: 533 KWDYVAALTTPRGGVGIATVMGKIFAVGGHNGN----AYLNTVEAFDPVLNRWELVGSVS 588
Query: 469 EARKNHGL 476
R G+
Sbjct: 589 HCRAGAGV 596
Score = 38.5 bits (88), Expect = 0.017
Identities = 27/91 (29%), Positives = 41/91 (45%), Gaps = 5/91 (5%)
Query: 483 IFAVGGQNGLGG-LDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGR 541
+F VGG+ G G ++E Y I N W M + V +V VY + G G
Sbjct: 320 LFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEH 379
Query: 542 LGHILEYNTETDKWV----ANSKVRAFPVTS 568
LG + ++ T+KW+ N+K R + S
Sbjct: 380 LGSMEMFDPLTNKWMMKASMNTKRRGIALAS 410
>gi|223890235 intracisternal A particle-promoted polypeptide isoform
2 [Homo sapiens]
Length = 582
Score = 240 bits (612), Expect = 3e-63
Identities = 167/556 (30%), Positives = 263/556 (47%), Gaps = 55/556 (9%)
Query: 12 KKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNL 71
K + ++ + A+L+ + +N MR + CDV L V + AHR+VLAA+S +F
Sbjct: 8 KAADSPFSSDKHAQLI---LAQINKMRNGQHFCDVQLQVGQESFKAHRLVLAASSPYFAA 64
Query: 72 MFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKK 131
+FT M ES V + E I + L++F YT +++ NNVQ L+ AA+ Q+ V
Sbjct: 65 LFTGGMKESSKDVVPILGIEAGIFQILLDFIYTGIVNIGVNNVQELIIAADMLQLTEVVH 124
Query: 132 MCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVT 191
+C +FLK Q+D NC+GI +E + C +L ++++IH HF EV+ +EFL L ++
Sbjct: 125 LCCEFLKGQIDPLNCIGIFQFSEQIACHDLLEFSENYIHVHFLEVHSGEEFLALTKDQLI 184
Query: 192 HLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQA-- 249
+L + L++ E QV+ AA++W+ D R+ +V++L +RFPL+ L K ++
Sbjct: 185 KILRSEELSIEDEYQVFLAAMQWILKDLGKRRKHVVEVLDPIRFPLLPPQRLLKYIEGVS 244
Query: 250 --------EPLIQDNPECLKMVISGMRYHLLSPEDREEL----VDGTRPRRKKHDYRIAL 297
+ L+++ E K SP++ + RPR+K Y A+
Sbjct: 245 DFNLRVALQTLLKEYCEVCK-----------SPKENKFCSFLQTSKVRPRKKARKYLYAV 293
Query: 298 FGGSQPQSCRYFNPKDYS-----------WTDIRCPFEKRRDAACVFWDNVVYILGG--- 343
G ++ Q R+ + + S WT + + R +VY +GG
Sbjct: 294 GGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGEKD 353
Query: 344 SQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSG---GSEVGNSALYLF 400
S +F +CY+ V W + PR L C G IY G G+E+GN+
Sbjct: 354 SMIFDC--TECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNT----I 407
Query: 401 ECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATET 460
E +D W +M R G E GLIYV GG + L S EVYDP ++
Sbjct: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIE---LRSFEVYDPLSKR 464
Query: 461 WTELCPMIEARKNHGLVFVKDKIFAVGGQNGL-GGLDNVEYYDIKLNEWKMVSPMPWKGV 519
W+ L PM R G+ + D I++VGG N L VE Y + +W V+ M
Sbjct: 465 WSPLPPMGTRRAYLGVAALNDCIYSVGGWNETQDALHTVEKYSFEEEKWVEVASMKVPRA 524
Query: 520 TVKCAAVGSIVYVLAG 535
+ AV ++YV G
Sbjct: 525 GMCVVAVNGLLYVSGG 540
Score = 71.2 bits (173), Expect = 2e-12
Identities = 47/178 (26%), Positives = 76/178 (42%), Gaps = 5/178 (2%)
Query: 379 AAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGS 438
A G GG + AL E +DT ++ W T S+ R G+ G++Y GG
Sbjct: 292 AVGGYTRLQGGRWSDSRALSCVERFDTFSQYWTTVSSLHQARSGLGVTVLGGMVYAIGGE 351
Query: 439 LGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNV 498
+ + + E YDP T+ WT + M R G+ I+A+GG G + +
Sbjct: 352 KDS----MIFDCTECYDPVTKQWTTVASMNHPRCGLGVCVCYGAIYALGGWVGAEIGNTI 407
Query: 499 EYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVG-RLGHILEYNTETDKW 555
E +D N+W++V M C + ++YV+ G G L Y+ + +W
Sbjct: 408 ERFDPDENKWEVVGNMAVSRYYFGCCEMQGLIYVIGGISNEGIELRSFEVYDPLSKRW 465
>gi|65289632 kelch-like 5 isoform 2 [Homo sapiens]
Length = 694
Score = 239 bits (610), Expect = 5e-63
Identities = 147/512 (28%), Positives = 250/512 (48%), Gaps = 61/512 (11%)
Query: 59 RVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLL 118
R+VL++ S +F MFT ++ E++ E++++ EP+ + L+++AYT R+ + +N++ LL
Sbjct: 174 RLVLSSVSDYFAAMFTNDVREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLL 233
Query: 119 DAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYK 178
A Q+ V + C FL +Q+ SNCLGI A+ C +L A ++ +HF EV +
Sbjct: 234 STACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIR 293
Query: 179 TDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLI 238
EF+ L + LL D + + E+ + +A + W+++D R+ + +LA +R PL+
Sbjct: 294 NQEFVLLPASEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSKLLAYIRLPLL 353
Query: 239 SKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVD-GTRPRRKKHDYRIAL 297
+ FL+ ++ L +D+ EC K+++ M+YHLL PE R L T+PR+ A+
Sbjct: 354 APQFLA-DMENNVLFRDDIECQKLIMEAMKYHLL-PERRPMLQSPRTKPRKSTVGTLFAV 411
Query: 298 FGGSQPQ---SCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQ-LFPIKRMD 353
G + S ++ + WT + +R D+ +Y++GG L + ++
Sbjct: 412 GGMDSTKGATSIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVE 471
Query: 354 CYNVVKDSWYSKLGPP-------------------------------------------- 369
CYN +W + PP
Sbjct: 472 CYNPKTKTW--SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNF 529
Query: 370 -----TPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHG 424
TPR ++ GK+Y GG + G+S L EC+D T W M +R G
Sbjct: 530 VATMSTPRSTVGVAVLSGKLYAVGGRD-GSSCLKSVECFDPHTNKWTLCAQMSKRRGGVG 588
Query: 425 MVEANGLIYVCGG--SLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDK 482
+ NGL+Y GG + +N++ R+ + E YDP T+ WT + M +R G+ + DK
Sbjct: 589 VTTWNGLLYAIGGHDAPASNLTSRLSDCVERYDPKTDMWTAVASMSISRDAVGVCLLGDK 648
Query: 483 IFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPM 514
++AVGG +G L+ VE YD + NEW V+P+
Sbjct: 649 LYAVGGYDGQAYLNTVEAYDPQTNEWTQVAPL 680
>gi|148664209 kelch-like 10 [Homo sapiens]
Length = 608
Score = 238 bits (607), Expect = 1e-62
Identities = 158/575 (27%), Positives = 268/575 (46%), Gaps = 28/575 (4%)
Query: 23 EAKLLAGFMGVMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKS 82
E K+ A + N +R + LCDV++ V + AH+ +L + S +F +FT+ ++
Sbjct: 18 ERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEK 77
Query: 83 FEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVD 142
+ PD+++ ++E+AYT + + +NV+ LL AA+Q+ I + + C +FLK ++
Sbjct: 78 KVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELC 137
Query: 143 ASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTD-EFLQLDVKRVTHLLNQDTLTV 201
NC+GI + CPEL+ A FI +F E+ K EFL+L V + ++ +D L V
Sbjct: 138 LDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNV 197
Query: 202 RAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLK 261
+ ED V++A ++W+ +D NR+ + +L KVR L+ + V+ ++D+ EC
Sbjct: 198 KQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKP 257
Query: 262 MVISGMR----YHLLSPEDREELVDGTRPRRKKHDYRIAL-----FGGSQPQSCRYFNPK 312
++I+ ++ ++ P + + TRPR Y I GGS + ++ +
Sbjct: 258 VIINALKAMYDLNMNGPSNSDFTNPLTRPRL---PYAILFAIGGWSGGSPTNAIEAYDAR 314
Query: 313 DYSWTDIRCPFEK-RRDAACVFWDNVVYILGG----SQLFPIKRMDCYNVVKDSWYSKLG 367
W ++ C E R + VYI+GG +KR D VK +W+
Sbjct: 315 ADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFD---PVKKTWHQVAP 371
Query: 368 PPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVE 427
+ R ++ IY GG + G L E Y+ T W M QR
Sbjct: 372 MHSRRCYVSVTVLGNFIYAMGGFD-GYVRLNTAERYEPETNQWTLIAPMHEQRSDASATT 430
Query: 428 ANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVG 487
G +Y+CGG GN L + EVY+ + WT + PM R G++ + ++AVG
Sbjct: 431 LYGKVYICGGFNGN----ECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVG 486
Query: 488 GQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILE 547
G +G L + E Y N W+ + M V +++V+ GF G ++
Sbjct: 487 GFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVEC 546
Query: 548 YNTETDKWVANSKVRAFPVTSCLICVVDTCGANEE 582
Y+ +TD+W + + S L C V AN E
Sbjct: 547 YDEKTDEWYDAHDMSIY--RSALSCCVVPGLANVE 579
>gi|40018614 DRE1 protein [Homo sapiens]
Length = 600
Score = 220 bits (560), Expect = 3e-57
Identities = 141/509 (27%), Positives = 238/509 (46%), Gaps = 60/509 (11%)
Query: 33 VMNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEP 92
+ N R + DVI+ V+ ++ P HR VL+A S +F MF + ES+ VE+
Sbjct: 55 IFNEFRDSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILA 114
Query: 93 DIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVL 152
+ +E +++ YT ++ + + NVQ L + ++ +QI ++ C FL+EQ+D NCLGI
Sbjct: 115 EAMECFLQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRF 174
Query: 153 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAV 212
A+ L +F Q F +V + +EFL+LD + + D L + E+ V++A +
Sbjct: 175 ADTHSLKTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVM 234
Query: 213 RWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLL 272
RW+ R+P + ++L VR PL+ N+ +TV+ + LIQ++PEC +++ RYH+L
Sbjct: 235 RWVYRAVDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHIL 294
Query: 273 SPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACV 332
E + TRPRR
Sbjct: 295 G---NEMMSPRTRPRRS------------------------------------------T 309
Query: 333 FWDNVVYILGGSQL---FPIKRMDCYNVVKDSWYS--KLGPPTPRDSLAACAAEGKIYTS 387
+ V+ ++GG + F + +CY+ V W S KL P + A CA I S
Sbjct: 310 GYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKL-PEFTKSEYAVCALRNDILVS 368
Query: 388 GGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRV 447
GG + + +++ Y+++ W S+ R H M G +YV GG G N
Sbjct: 369 GG-RINSRDVWI---YNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQN----R 420
Query: 448 LNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAV-GGQNGLGGLDNVEYYDIKLN 506
L+S E YD + WTE+ P+ EA + + K+F + GG + D V+ YD + N
Sbjct: 421 LSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETN 480
Query: 507 EWKMVSPMPWKGVTVKCAAVGSIVYVLAG 535
W + + +P + ++ +++YV G
Sbjct: 481 SWLLRAAIPIAKRCITAVSLNNLIYVAGG 509
Score = 57.8 bits (138), Expect = 3e-08
Identities = 51/229 (22%), Positives = 88/229 (38%), Gaps = 17/229 (7%)
Query: 353 DCYNVVKDSW-YSKLG----PPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRT 407
+CY ++ ++ Y LG P R + +E + G VG L ECYD T
Sbjct: 280 ECYQLLHEARRYHILGNEMMSPRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVT 339
Query: 408 ESWHTKPSMLT-QRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 466
W + + + + + I V GG + + +Y+ W +
Sbjct: 340 GEWKSLAKLPEFTKSEYAVCALRNDILVSGGRINSR-------DVWIYNSQLNIWIRVAS 392
Query: 467 MIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWK-GVTVKCAA 525
+ + R H + + K++ VGG +G L +VE YD N W V+P+ +
Sbjct: 393 LNKGRWRHKMAVLLGKVYVVGGYDGQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSC 452
Query: 526 VGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICVV 574
VG + + G + Y+ ET+ W+ + A P+ I V
Sbjct: 453 VGKLFVIGGGPDDNTCSDKVQSYDPETNSWLLRA---AIPIAKRCITAV 498
Score = 52.0 bits (123), Expect = 2e-06
Identities = 43/183 (23%), Positives = 74/183 (40%), Gaps = 11/183 (6%)
Query: 299 GGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGS--QLFPIKRMDCYN 356
G ++ S ++ WT++ E A ++++GG ++ Y+
Sbjct: 417 GQNRLSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYD 476
Query: 357 VVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSM 416
+SW + P + + A + IY +GG A+Y CYD + W +
Sbjct: 477 PETNSWLLRAAIPIAKRCITAVSLNNLIYVAGGL---TKAIY---CYDPVEDYWMHVQNT 530
Query: 417 LTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGL 476
+++ + GM NG IY+ GG N G ++ YDPAT T + M HG
Sbjct: 531 FSRQENCGMSVCNGKIYILGGRREN---GEATDTILCYDPATSIITGVAAMPRPVSYHGC 587
Query: 477 VFV 479
V +
Sbjct: 588 VTI 590
>gi|239753123 PREDICTED: kelch-like 29 (Drosophila) [Homo sapiens]
Length = 875
Score = 211 bits (538), Expect = 1e-54
Identities = 144/472 (30%), Positives = 230/472 (48%), Gaps = 22/472 (4%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES-----KSFEVELK 88
+N R+ K D+ ++V+ R+ H+ VLA+ S +F + ++ +S + E+ L
Sbjct: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
Query: 89 DAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLG 148
+ + D++E L+EF YT + ++S N ++LL+AA+++Q K+CV FL++Q+ ASNCLG
Sbjct: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Query: 149 ISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVY 208
+ +AE + C EL A F Q F EV +E L + ++ D+L +AE+ VY
Sbjct: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
Query: 209 DAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMR 268
+ ++W+K D R + ++LA VR P I ++L V E LI+ + C +V R
Sbjct: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
Query: 269 YHLLSPEDREELVDGTRPRRKKHDYR-IALFGGSQP--------QSCRYFNPKDYSWTDI 319
YH+L +E TRPR I L GG Q + +NP++ W +
Sbjct: 559 YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
Query: 320 -RCPFEKRRDAACVFWDNVVYILGGSQL-FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAA 377
PF R + V + +Y+ GG + + + CY + D+W PR +
Sbjct: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNS 678
Query: 378 CAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGG 437
+GKIYT GG V + ++ E YDT T W + S G IYV GG
Sbjct: 679 LVYDGKIYTLGGLGVAGNVDHV-ERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGG 737
Query: 438 SLGNNVSGRVLNSCEVYDPATETWTEL-CPMIEARKNHGLVFVKDKIFAVGG 488
N +GR + Y P T TW+ + PMI+ K V + +F +GG
Sbjct: 738 V---NEAGRAAGVLQSYVPQTNTWSFIESPMID-NKYAPAVTLNGFVFILGG 785
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 8/191 (4%)
Query: 369 PTPRDSLAACAAEGKIYTSGGSEVGNS--ALYLFECYDTRTESWHTKPSM-LTQRCSHGM 425
P R L+A AE + G VG + +L C++ + W+ S+ R +
Sbjct: 572 PRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSV 631
Query: 426 VEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFA 485
V A IY+ GG SG L Y + W + M R H + KI+
Sbjct: 632 VSAGDNIYLSGGM----ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYT 687
Query: 486 VGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHI 545
+GG G +D+VE YD N+W+ V+P+P + G +YV G GR +
Sbjct: 688 LGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGV 747
Query: 546 LE-YNTETDKW 555
L+ Y +T+ W
Sbjct: 748 LQSYVPQTNTW 758
Score = 45.4 bits (106), Expect = 1e-04
Identities = 39/152 (25%), Positives = 61/152 (40%), Gaps = 8/152 (5%)
Query: 411 HTKPSMLTQRC----SHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 466
H + M T R S G+ E +I + GG ++ R L + ++P W L
Sbjct: 564 HARQEMQTPRTRPRLSAGVAE---VIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLAS 620
Query: 467 M-IEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAA 525
+ R+ +V D I+ GG L +V Y L+ W +VS M
Sbjct: 621 LPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV 680
Query: 526 VGSIVYVLAGFQGVGRLGHILEYNTETDKWVA 557
+Y L G G + H+ Y+T T++W A
Sbjct: 681 YDGKIYTLGGLGVAGNVDHVERYDTITNQWEA 712
Score = 41.2 bits (95), Expect = 0.003
Identities = 41/142 (28%), Positives = 60/142 (42%), Gaps = 15/142 (10%)
Query: 294 RIALFGGSQPQS-----CRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP 348
+I +FGG + + P+ +W+ I P + A V + V+ILGG+
Sbjct: 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAY--- 787
Query: 349 IKRMDCYNVVKDSWYSKLGPPT--PRDSLAACAAEGKIYTSGG--SEVGNSALYLFECYD 404
+ Y+ K + K GP R +A +GKIY +GG S G AL E Y+
Sbjct: 788 ARATTIYDPEKGN--IKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEG-PALGNMEAYE 844
Query: 405 TRTESWHTKPSMLTQRCSHGMV 426
T +W P M HG V
Sbjct: 845 PTTNTWTLLPHMPCPVFRHGCV 866
>gi|239741555 PREDICTED: kelch repeat and BTB (POZ) domain
containing 9 [Homo sapiens]
Length = 875
Score = 211 bits (538), Expect = 1e-54
Identities = 144/472 (30%), Positives = 230/472 (48%), Gaps = 22/472 (4%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES-----KSFEVELK 88
+N R+ K D+ ++V+ R+ H+ VLA+ S +F + ++ +S + E+ L
Sbjct: 319 LNQQRRAKAFTDLKIVVEGREFEVHQNVLASCSLYFKDLIQRSVQDSGQGGREKLELVLS 378
Query: 89 DAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLG 148
+ + D++E L+EF YT + ++S N ++LL+AA+++Q K+CV FL++Q+ ASNCLG
Sbjct: 379 NLQADVLELLLEFVYTGSLVIDSANAKTLLEAASKFQFHTFCKVCVSFLEKQLTASNCLG 438
Query: 149 ISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVY 208
+ +AE + C EL A F Q F EV +E L + ++ D+L +AE+ VY
Sbjct: 439 VLAMAEAMQCSELYHMAKAFALQIFPEVAAQEEILSISKDDFIAYVSNDSLNTKAEELVY 498
Query: 209 DAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMR 268
+ ++W+K D R + ++LA VR P I ++L V E LI+ + C +V R
Sbjct: 499 ETVIKWIKKDPATRTQYAAELLAVVRLPFIHPSYLLNVVDNEELIKSSEACRDLVNEAKR 558
Query: 269 YHLLSPEDREELVDGTRPRRKKHDYR-IALFGGSQP--------QSCRYFNPKDYSWTDI 319
YH+L +E TRPR I L GG Q + +NP++ W +
Sbjct: 559 YHMLPHARQEMQTPRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPL 618
Query: 320 -RCPFEKRRDAACVFWDNVVYILGGSQL-FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAA 377
PF R + V + +Y+ GG + + + CY + D+W PR +
Sbjct: 619 ASLPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNS 678
Query: 378 CAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGG 437
+GKIYT GG V + ++ E YDT T W + S G IYV GG
Sbjct: 679 LVYDGKIYTLGGLGVAGNVDHV-ERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGG 737
Query: 438 SLGNNVSGRVLNSCEVYDPATETWTEL-CPMIEARKNHGLVFVKDKIFAVGG 488
N +GR + Y P T TW+ + PMI+ K V + +F +GG
Sbjct: 738 V---NEAGRAAGVLQSYVPQTNTWSFIESPMID-NKYAPAVTLNGFVFILGG 785
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/191 (27%), Positives = 81/191 (42%), Gaps = 8/191 (4%)
Query: 369 PTPRDSLAACAAEGKIYTSGGSEVGNS--ALYLFECYDTRTESWHTKPSM-LTQRCSHGM 425
P R L+A AE + G VG + +L C++ + W+ S+ R +
Sbjct: 572 PRTRPRLSAGVAEVIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLASLPFYDREFFSV 631
Query: 426 VEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFA 485
V A IY+ GG SG L Y + W + M R H + KI+
Sbjct: 632 VSAGDNIYLSGGM----ESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLVYDGKIYT 687
Query: 486 VGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHI 545
+GG G +D+VE YD N+W+ V+P+P + G +YV G GR +
Sbjct: 688 LGGLGVAGNVDHVERYDTITNQWEAVAPLPKAVHSAAATVCGGKIYVFGGVNEAGRAAGV 747
Query: 546 LE-YNTETDKW 555
L+ Y +T+ W
Sbjct: 748 LQSYVPQTNTW 758
Score = 45.4 bits (106), Expect = 1e-04
Identities = 39/152 (25%), Positives = 61/152 (40%), Gaps = 8/152 (5%)
Query: 411 HTKPSMLTQRC----SHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCP 466
H + M T R S G+ E +I + GG ++ R L + ++P W L
Sbjct: 564 HARQEMQTPRTRPRLSAGVAE---VIVLVGGRQMVGMTQRSLVAVTCWNPQNNKWYPLAS 620
Query: 467 M-IEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAA 525
+ R+ +V D I+ GG L +V Y L+ W +VS M
Sbjct: 621 LPFYDREFFSVVSAGDNIYLSGGMESGVTLADVWCYMSLLDNWNLVSRMTVPRCRHNSLV 680
Query: 526 VGSIVYVLAGFQGVGRLGHILEYNTETDKWVA 557
+Y L G G + H+ Y+T T++W A
Sbjct: 681 YDGKIYTLGGLGVAGNVDHVERYDTITNQWEA 712
Score = 41.2 bits (95), Expect = 0.003
Identities = 41/142 (28%), Positives = 60/142 (42%), Gaps = 15/142 (10%)
Query: 294 RIALFGGSQPQS-----CRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFP 348
+I +FGG + + P+ +W+ I P + A V + V+ILGG+
Sbjct: 731 KIYVFGGVNEAGRAAGVLQSYVPQTNTWSFIESPMIDNKYAPAVTLNGFVFILGGAY--- 787
Query: 349 IKRMDCYNVVKDSWYSKLGPPT--PRDSLAACAAEGKIYTSGG--SEVGNSALYLFECYD 404
+ Y+ K + K GP R +A +GKIY +GG S G AL E Y+
Sbjct: 788 ARATTIYDPEKGN--IKAGPNMNHSRQFCSAVVLDGKIYATGGIVSSEG-PALGNMEAYE 844
Query: 405 TRTESWHTKPSMLTQRCSHGMV 426
T +W P M HG V
Sbjct: 845 PTTNTWTLLPHMPCPVFRHGCV 866
>gi|4505461 ectodermal-neural cortex (with BTB-like domain) [Homo
sapiens]
Length = 589
Score = 210 bits (535), Expect = 3e-54
Identities = 148/540 (27%), Positives = 239/540 (44%), Gaps = 59/540 (10%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDA-EP 92
+N +R+Q+ DV+L R P HR VLAA S +F MF+ + ES+ EV ++ P
Sbjct: 36 LNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHP 95
Query: 93 DIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVL 152
+++E L+++AY++R+ +N N +SLL+A + + + ++ C +FL++ + +NCLG+ +L
Sbjct: 96 EVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLL 155
Query: 153 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAV 212
++ C +L + +F + K ++FLQL V LL+ + L E VY++A+
Sbjct: 156 SDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAI 215
Query: 213 RWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHL- 271
W+ YD R ++ ++L VR L+ +L + V E LI + ++V +R L
Sbjct: 216 NWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLK 275
Query: 272 LSPEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAAC 331
+ D RPR+ H
Sbjct: 276 ILQNDGVVTSLCARPRKTGH---------------------------------------- 295
Query: 332 VFWDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSE 391
+++LGG Q F ++ + K P+PR +ACA K+Y +GG
Sbjct: 296 -----ALFLLGG-QTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRG 349
Query: 392 VGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNN----VSGRV 447
N YDT E W ML R HG E +YV GG S V
Sbjct: 350 SENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSV 409
Query: 448 -LNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQN-GLGGLDNVEYYDIKL 505
L E YDP WT + P+ E N +V K K+FA GG + L V+ YD
Sbjct: 410 SLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCE 469
Query: 506 NEWKM--VSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRA 563
N W + P PW+ A +G+ ++++ G ++N+ET +W V A
Sbjct: 470 NRWTVPATCPQPWR--YTAAAVLGNQIFIMGGDTEFSACS-AYKFNSETYQWTKVGDVTA 526
>gi|8922854 kelch-like 26 [Homo sapiens]
Length = 615
Score = 208 bits (529), Expect = 1e-53
Identities = 155/544 (28%), Positives = 249/544 (45%), Gaps = 36/544 (6%)
Query: 37 MRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIE 96
+R Q L DV+L + PAH+VVLAA S +F MFT M E+ +ELK +
Sbjct: 56 LRAQGQLLDVVLTINREAFPAHKVVLAACSDYFRAMFTGGMREASQDVIELKGVSARGLR 115
Query: 97 QLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECL 156
+++FAY+A ++++ + VQ +L AA Q+ PV ++C +FLK + CL I +A
Sbjct: 116 HIIDFAYSAEVTLDLDCVQDVLGAAVFLQMLPVVELCEEFLKAAMSVETCLNIGQMATTF 175
Query: 157 DCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLK 216
L+ + D F +HF ++ + ++FL+L ++R+ L + L AE ++ AAVRWL+
Sbjct: 176 SLASLRESVDAFTFRHFLQIAEEEDFLRLPLERLVFFLQSNRLQSCAEIDLFRAAVRWLQ 235
Query: 217 YDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPED 276
+D P R+P +L +RFPL+ + L +VQ ++ ++ C + ++ Y +L
Sbjct: 236 HD-PARRPRASHVLCHIRFPLMQSSELVDSVQTLDIMVEDVLCRQYLLEAFNYQVL--PF 292
Query: 277 REELVDGTRPRRKKHDYRIALFGGS-QPQSCRYFNPKDYSWTDIRC-------PFEKRRD 328
R+ + R + + FGG+ S R + K Y + E
Sbjct: 293 RQHEMQSPRTAVRSDVPSLVTFGGTPYTDSDRSVSSKVYQLPEPGARHFRELTEMEVGCS 352
Query: 329 AACV-FWDNVVYILGGSQL------FPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAE 381
CV DN VY+ GG L + Y+ + W R
Sbjct: 353 HTCVAVLDNFVYVAGGQHLQYRSGEGAVDACYRYDPHLNRWLRLQAMQESRIQFQLNVLC 412
Query: 382 GKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGN 441
G +Y +GG S L E Y R W S+ + H + G +Y+ GG G
Sbjct: 413 GMVYATGGRNRAGS-LASVERYCPRRNEWGYACSLKRRTWGHAGAASGGRLYISGG-YGI 470
Query: 442 NVSGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDN---- 497
+V + C YDP + W PM E R H +V +I+A+GG+ + +D
Sbjct: 471 SVEDKKALHC--YDPVADQWEFKAPMSEPRVLHAMVGAGGRIYALGGR--MDHVDRCFDV 526
Query: 498 --VEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRL----GHILEYNTE 551
VEYY + ++W VSPM C + +Y++ G+ RL G + YNT+
Sbjct: 527 LAVEYYVPETDQWTSVSPMRAGQSEAGCCLLERKIYIVGGYN--WRLNNVTGIVQVYNTD 584
Query: 552 TDKW 555
TD+W
Sbjct: 585 TDEW 588
>gi|109150407 kelch-like 6 [Homo sapiens]
Length = 621
Score = 201 bits (510), Expect = 2e-51
Identities = 136/523 (26%), Positives = 231/523 (44%), Gaps = 47/523 (8%)
Query: 34 MNNMRKQKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPD 93
+ +R + L DVIL V ++ HRVVLAAAS++F MF ++ E + +K + +
Sbjct: 62 LETLRMENALTDVILCVDIQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAE 121
Query: 94 IIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLGISVLA 153
+ L+++ YT++ + NVQ +L+AAN +Q + C FL E ++ NC+GI LA
Sbjct: 122 TMHTLLDYTYTSKALITKQNVQRVLEAANLFQFLRMVDACASFLTEALNPENCVGILRLA 181
Query: 154 ECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVR 213
+ LK +I Q+F ++ ++EFL L V + H+L D L V E QV++ +
Sbjct: 182 DTHSLDSLKKQVQSYIIQNFVQILNSEEFLDLPVDTLHHILKSDDLYVTEEAQVFETVMS 241
Query: 214 WLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHLLS 273
W+++ R + +L VR PL+ + +TV+A+PLI+ PE ++ YHL
Sbjct: 242 WVRHKPSERLCLLPYVLENVRLPLLDPWYFVETVEADPLIRQCPEVFPLLQEARMYHL-- 299
Query: 274 PEDREELVDGTRPRRKKHDYRIALFGGSQPQSCRYFNPKDYSWTDIRCPFEKRRDAACVF 333
E + + T+PR + + + G + R+ ++ C RR V
Sbjct: 300 -SGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFV-------AEVTCLDPLRRSRLEV- 350
Query: 334 WDNVVYILGGSQLFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVG 393
P+ + + K W A + ++Y SGG E
Sbjct: 351 -----------AKLPLTEHELESENK-KWV----------EFACVTLKNEVYISGGKETQ 388
Query: 394 NSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEV 453
+ Y++ W + R H MV G +YV GG G + +N+ E
Sbjct: 389 HDVWK----YNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVIGGFDGL----QRINNVET 440
Query: 454 YDPATETWTELCPMIEARKNHGLVFVKDKIFAV-GGQNGLGGLDNVEYYDIKLNEWKMVS 512
YDP W+E P++ + K K++ + GG NG D + YD N+W + +
Sbjct: 441 YDPFHNCWSEAAPLLVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWSLKA 500
Query: 513 PMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 555
MP + + + +YV+ G + + Y+ D W
Sbjct: 501 AMPVEAKCINAVSFRDRIYVVG-----GAMRALYAYSPLEDSW 538
Score = 51.2 bits (121), Expect = 3e-06
Identities = 36/145 (24%), Positives = 60/145 (41%), Gaps = 11/145 (7%)
Query: 338 VYILGGSQ--LFPIKRMDCYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNS 395
+Y++GG + CY+ + W K P + A + +IY GG+
Sbjct: 470 LYVIGGGPNGKLATDKTQCYDPSTNKWSLKAAMPVEAKCINAVSFRDRIYVVGGAM---R 526
Query: 396 ALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYD 455
ALY Y +SW + +R S G+ N +Y+ GG N V+ + +D
Sbjct: 527 ALY---AYSPLEDSWCLVTQLSHERASCGIAPCNNRLYITGGRDEKN---EVIATVLCWD 580
Query: 456 PATETWTELCPMIEARKNHGLVFVK 480
P + TE C + +HG V ++
Sbjct: 581 PEAQKLTEECVLPRGVSHHGSVTIR 605
>gi|45643138 kelch-like 13 [Homo sapiens]
Length = 655
Score = 198 bits (504), Expect = 1e-50
Identities = 140/574 (24%), Positives = 253/574 (44%), Gaps = 33/574 (5%)
Query: 3 ASGVEKSSKKKTEKKLAAREEAKLLAGFMGVMNNMRKQKTLCDVILMVQERK--IPAHRV 60
+S ++ S T + + +L GF + +R + LCDV LM + P HRV
Sbjct: 55 SSHLQSSKAGPTRIFTSNTHSSVVLQGF----DQLRLEGLLCDVTLMPGDTDDAFPVHRV 110
Query: 61 VLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDA 120
++A+AS +F MFT M E ++L + ++++F YTA++S+N +N+Q L+A
Sbjct: 111 MMASASDYFKAMFTGGMKEQDLMCIKLHGVSKVGLRKIIDFIYTAKLSLNMDNLQDTLEA 170
Query: 121 ANQYQIEPVKKMCVDFLKEQVDASNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTD 180
A+ QI PV C FL V NC+ + +A + E+ + F+ ++F + T
Sbjct: 171 ASFLQILPVLDFCKVFLISGVTLDNCVEVGRIANTYNLTEVDKYVNSFVLKNFPALLSTG 230
Query: 181 EFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISK 240
EFL+L +R+ +L+ ++L E +++ A RWL+ +EP R F ++ +RFPL++
Sbjct: 231 EFLKLPFERLAFVLSSNSLKHCTELELFKATCRWLRLEEP-RMDFAAKLMKNIRFPLMTP 289
Query: 241 NFLSKTVQAEPLIQDNPECLKMVISGMRYHLLSPEDREELVDGTRPRRKKHDYRIALFGG 300
L VQ ++ + C+ +++ Y ++ + ++ R + + GG
Sbjct: 290 QELINYVQTVDFMRTDNTCVNLLLEASNYQMM--PYMQPVMQSDRTAIRSDTTHLVTLGG 347
Query: 301 SQPQ------SCRYFNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQLFPIKRMDC 354
Q R ++ K + W + R N +Y++GG + K
Sbjct: 348 VLRQQLVVSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTA 407
Query: 355 YNVV------KDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTE 408
+ V + W R A +G +Y GG L ECY+ RT
Sbjct: 408 VDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGE-LPTVECYNPRTN 466
Query: 409 SWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVLNSCEVYDPATETWTELCPMI 468
W M H G++Y+ GG + ++ +DP T+ W + PM
Sbjct: 467 EWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQKELM----CFDPDTDKWIQKAPMT 522
Query: 469 EARKNHGLVFVKDKIFAVGGQNGLGGLD-----NVEYYDIKLNEWKMVSPMPWKGVTVKC 523
R H + V ++++ +GG + G D + EYY L++W ++ M V
Sbjct: 523 TVRGLHCMCTVGERLYVIGGNHFRGTSDYDDVLSCEYYSPILDQWTPIAAMLRGQSDVGV 582
Query: 524 AAVGSIVYVLAGFQGVGR--LGHILEYNTETDKW 555
A + +YV+ G+ R + + +Y+ + D+W
Sbjct: 583 AVFENKIYVVGGYSWNNRCMVEIVQKYDPDKDEW 616
Score = 76.6 bits (187), Expect = 6e-14
Identities = 43/172 (25%), Positives = 75/172 (43%), Gaps = 1/172 (0%)
Query: 403 YDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRV-LNSCEVYDPATETW 461
YD + W + M R HG+ +YV GG + G+ +++ +DP W
Sbjct: 362 YDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKW 421
Query: 462 TELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTV 521
++ + E R L +K ++AVGG+N G L VE Y+ + NEW V+ M
Sbjct: 422 MQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGH 481
Query: 522 KCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKVRAFPVTSCLICV 573
G ++Y+ G ++ ++ +TDKW+ + + C+ V
Sbjct: 482 AGTVYGGVMYISGGITHDTFQKELMCFDPDTDKWIQKAPMTTVRGLHCMCTV 533
Score = 58.9 bits (141), Expect = 1e-08
Identities = 32/120 (26%), Positives = 54/120 (45%), Gaps = 5/120 (4%)
Query: 447 VLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQN-----GLGGLDNVEYY 501
V +YD W L PM R HG+ + + ++ VGGQ+ G +D V +
Sbjct: 355 VSKELRMYDEKAHEWKSLAPMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDTVFRF 414
Query: 502 DIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVANSKV 561
D + N+W V+ + K +A+ +Y + G G L + YN T++W +K+
Sbjct: 415 DPRYNKWMQVASLNEKRTFFHLSALKGYLYAVGGRNAAGELPTVECYNPRTNEWTYVAKM 474
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,050,917
Number of Sequences: 37866
Number of extensions: 968494
Number of successful extensions: 3211
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 171
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2028
Number of HSP's gapped (non-prelim): 348
length of query: 586
length of database: 18,247,518
effective HSP length: 108
effective length of query: 478
effective length of database: 14,157,990
effective search space: 6767519220
effective search space used: 6767519220
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.