Search of human proteins with 111607457

Search of human proteins with 111607457

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|111607457 deafness, autosomal recessive 59 [Homo sapiens]
         (352 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|111607457 deafness, autosomal recessive 59 [Homo sapiens]          707   0.0  
gi|4758154 deafness, autosomal dominant 5 protein isoform a [Hom...   137   1e-32
gi|188536092 deafness, autosomal dominant 5 protein isoform a [H...   137   1e-32
gi|150456463 gasdermin 1 [Homo sapiens]                                63   3e-10
gi|188536094 deafness, autosomal dominant 5 protein isoform b [H...    51   2e-06
gi|83320070 gasdermin D [Homo sapiens]                                 50   4e-06
gi|109689703 gasdermin-like isoform 1 [Homo sapiens]                   38   0.012
gi|109689711 gasdermin-like isoform 2 [Homo sapiens]                   38   0.012
gi|25777746 piggyBac transposable element derived 4 [Homo sapiens]     30   2.5  
gi|4885391 hyaluronan synthase 2 [Homo sapiens]                        28   9.5  
gi|15619013 43 kD receptor-associated protein of the synapse iso...    28   9.5  

>gi|111607457 deafness, autosomal recessive 59 [Homo sapiens]
          Length = 352

 Score =  707 bits (1824), Expect = 0.0
 Identities = 352/352 (100%), Positives = 352/352 (100%)

Query: 1   MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKD 60
           MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKD
Sbjct: 1   MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKD 60

Query: 61  ILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVT 120
           ILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVT
Sbjct: 61  ILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVT 120

Query: 121 KHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGE 180
           KHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGE
Sbjct: 121 KHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGE 180

Query: 181 AMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVSKGGFEREETA 240
           AMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVSKGGFEREETA
Sbjct: 181 AMRFHFMDEQNPKGRDKAIVFPAHTTIAFSVFELFIYLDGAFDLCVTSVSKGGFEREETA 240

Query: 241 TFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLL 300
           TFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLL
Sbjct: 241 TFALLYRLRNILFERNRRVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLL 300

Query: 301 NHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK 352
           NHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK
Sbjct: 301 NHNIPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKRMK 352


>gi|4758154 deafness, autosomal dominant 5 protein isoform a [Homo
           sapiens]
          Length = 496

 Score =  137 bits (346), Expect = 1e-32
 Identities = 85/258 (32%), Positives = 142/258 (55%), Gaps = 30/258 (11%)

Query: 1   MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKR--CFLFPRYKFTSTPFTL 58
           MFA AT++F+++V   G L+ V +L+++DK Q LSLV KKKR  C+  P+Y+F S   TL
Sbjct: 1   MFAKATRNFLREVDADGDLIAVSNLNDSDKLQLLSLVTKKKRFWCWQRPKYQFLS--LTL 58

Query: 59  KDILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHI-------VNDVGINVAGSDSIA 111
            D+L+ D+  S  +     + YE        G+  NH+       +  V +N+ GS  + 
Sbjct: 59  GDVLIEDQFPSPVVVESDFVKYE--------GKFANHVSGTLETALGKVKLNLGGSSRVE 110

Query: 112 VKASFGIVTKHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSL 171
            ++SFG + K EV++  L+++   R IN  + +++Q    R  VLCV+ + I T ++C +
Sbjct: 111 SQSSFGTLRKQEVDLQQLIRDSAERTINLRNPVLQQVLEGRNEVLCVLTQKITTMQKCVI 170

Query: 172 SVH----------AGIRGEAMRFHFMDEQN-PKGRDKAIVFPAHTTIAFSVFELFIYLDG 220
           S H           GI+ + ++    ++ N  K  +  +  PA TTIA+ V EL++ LDG
Sbjct: 171 SEHMQVEEKCGGIVGIQTKTVQVSATEDGNVTKDSNVVLEIPAATTIAYGVIELYVKLDG 230

Query: 221 AFDLCVTSVSKGGFEREE 238
            F+ C+    +GGFE ++
Sbjct: 231 QFEFCLLRGKQGGFENKK 248


>gi|188536092 deafness, autosomal dominant 5 protein isoform a [Homo
           sapiens]
          Length = 496

 Score =  137 bits (346), Expect = 1e-32
 Identities = 85/258 (32%), Positives = 142/258 (55%), Gaps = 30/258 (11%)

Query: 1   MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKR--CFLFPRYKFTSTPFTL 58
           MFA AT++F+++V   G L+ V +L+++DK Q LSLV KKKR  C+  P+Y+F S   TL
Sbjct: 1   MFAKATRNFLREVDADGDLIAVSNLNDSDKLQLLSLVTKKKRFWCWQRPKYQFLS--LTL 58

Query: 59  KDILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHI-------VNDVGINVAGSDSIA 111
            D+L+ D+  S  +     + YE        G+  NH+       +  V +N+ GS  + 
Sbjct: 59  GDVLIEDQFPSPVVVESDFVKYE--------GKFANHVSGTLETALGKVKLNLGGSSRVE 110

Query: 112 VKASFGIVTKHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSL 171
            ++SFG + K EV++  L+++   R IN  + +++Q    R  VLCV+ + I T ++C +
Sbjct: 111 SQSSFGTLRKQEVDLQQLIRDSAERTINLRNPVLQQVLEGRNEVLCVLTQKITTMQKCVI 170

Query: 172 SVH----------AGIRGEAMRFHFMDEQN-PKGRDKAIVFPAHTTIAFSVFELFIYLDG 220
           S H           GI+ + ++    ++ N  K  +  +  PA TTIA+ V EL++ LDG
Sbjct: 171 SEHMQVEEKCGGIVGIQTKTVQVSATEDGNVTKDSNVVLEIPAATTIAYGVIELYVKLDG 230

Query: 221 AFDLCVTSVSKGGFEREE 238
            F+ C+    +GGFE ++
Sbjct: 231 QFEFCLLRGKQGGFENKK 248


>gi|150456463 gasdermin 1 [Homo sapiens]
          Length = 445

 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 57/225 (25%), Positives = 101/225 (44%), Gaps = 24/225 (10%)

Query: 1   MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKD 60
           MF   T++  +Q+   G L P+ SL +  ++ P  LV++K++  LF   ++  T +TL D
Sbjct: 3   MFENVTRALARQLNPRGDLTPLDSLIDFKRFHPFCLVLRKRKSTLFWGARYVRTDYTLLD 62

Query: 61  ILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVT 120
           +L        G S        D +D   +G + N +   V  +V    ++ VK + G+  
Sbjct: 63  VL------EPGSSP------SDPTDTGNFGFK-NMLDTRVEGDVDVPKTVKVKGTAGLSQ 109

Query: 121 KHEVEVSTL------LKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVH 174
              +EV TL      L+ +  RK+  DH  +++ +   +  L VVME + T ++ +L   
Sbjct: 110 NSTLEVQTLSVAPKALETVQERKLAADHPFLKEMQDQGEN-LYVVMEVVETVQEVTLE-R 167

Query: 175 AGIRGEAMRFHF---MDEQNPKGRDKAIVFPAHTTIAFSVFELFI 216
           AG         F   +  Q      +A+  P    +AF V +L +
Sbjct: 168 AGKAEACFSLPFFAPLGLQGSINHKEAVTIPKGCVLAFRVRQLMV 212


>gi|188536094 deafness, autosomal dominant 5 protein isoform b [Homo
           sapiens]
          Length = 332

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 27/83 (32%), Positives = 47/83 (56%), Gaps = 3/83 (3%)

Query: 157 CVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQN-PKGRDKAIVFPAHTTIAFSVFELF 215
           CV+ E ++   +C   V  GI+ + ++    ++ N  K  +  +  PA TTIA+ V EL+
Sbjct: 4   CVISEHMQVEEKCGGIV--GIQTKTVQVSATEDGNVTKDSNVVLEIPAATTIAYGVIELY 61

Query: 216 IYLDGAFDLCVTSVSKGGFEREE 238
           + LDG F+ C+    +GGFE ++
Sbjct: 62  VKLDGQFEFCLLRGKQGGFENKK 84


>gi|83320070 gasdermin D [Homo sapiens]
          Length = 484

 Score = 49.7 bits (117), Expect = 4e-06
 Identities = 60/232 (25%), Positives = 104/232 (44%), Gaps = 24/232 (10%)

Query: 2   FAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLF--PRYKFTSTPFTLK 59
           F    +  V+++  GG  +PV SL  +  +QP  LVV+K     F  PRYK  +   ++K
Sbjct: 5   FERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVN--LSIK 62

Query: 60  DILLGDR---EISAGIS--SYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKA 114
           DIL  D    ++  G S   Y  ++ + +  V L       I     ++ + S S+ V +
Sbjct: 63  DILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYS 122

Query: 115 SFGIVTKHEVEVSTLLKEITTRKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVH 174
               ++       TLL E   R+   +H +++Q R SR   + VV E ++T ++  ++  
Sbjct: 123 ----LSVDPNTWQTLLHERHLRQP--EHKVLQQLR-SRGDNVYVVTEVLQTQKEVEVT-R 174

Query: 175 AGIRGEAMRFHFM-------DEQNPKGRDKAIVFPAHTTIAFSVFELFIYLD 219
              R  + RF          + Q    + K +  P+ +T+AF V +L I  D
Sbjct: 175 THKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSD 226


>gi|109689703 gasdermin-like isoform 1 [Homo sapiens]
          Length = 403

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 38/147 (25%), Positives = 64/147 (43%), Gaps = 23/147 (15%)

Query: 1   MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKD 60
           +F   T+  VK++  GG ++ V SL +AD+++   LV +K+  F    Y   +T  TL D
Sbjct: 4   VFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHY---TTGLTLMD 60

Query: 61  ILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVT 120
           IL  D +            + DE D  L G++    + D   NV  +  + V+       
Sbjct: 61  ILDTDGD-----------KWLDELDSGLQGQKAEFQILD---NVDSTGELIVR------L 100

Query: 121 KHEVEVSTLLKEITTRKINFDHSLIRQ 147
             E+ +S   +    +KI    + I Q
Sbjct: 101 PKEITISGSFQGFHHQKIKISENRISQ 127


>gi|109689711 gasdermin-like isoform 2 [Homo sapiens]
          Length = 394

 Score = 38.1 bits (87), Expect = 0.012
 Identities = 38/147 (25%), Positives = 64/147 (43%), Gaps = 23/147 (15%)

Query: 1   MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRYKFTSTPFTLKD 60
           +F   T+  VK++  GG ++ V SL +AD+++   LV +K+  F    Y   +T  TL D
Sbjct: 4   VFEEITRIVVKEMDAGGDMIAVRSLVDADRFRCFHLVGEKRTFFGCRHY---TTGLTLMD 60

Query: 61  ILLGDREISAGISSYQLLNYEDESDVSLYGRRGNHIVNDVGINVAGSDSIAVKASFGIVT 120
           IL  D +            + DE D  L G++    + D   NV  +  + V+       
Sbjct: 61  ILDTDGD-----------KWLDELDSGLQGQKAEFQILD---NVDSTGELIVR------L 100

Query: 121 KHEVEVSTLLKEITTRKINFDHSLIRQ 147
             E+ +S   +    +KI    + I Q
Sbjct: 101 PKEITISGSFQGFHHQKIKISENRISQ 127


>gi|25777746 piggyBac transposable element derived 4 [Homo sapiens]
          Length = 585

 Score = 30.4 bits (67), Expect = 2.5
 Identities = 17/52 (32%), Positives = 24/52 (46%), Gaps = 12/52 (23%)

Query: 305 PKGPCILCGMG------NFKRETVYGCFQCSVDGQKYVRLHAVPCFDIWHKR 350
           P G C +C           ++ET Y C +C V       L  VPCF+I+H +
Sbjct: 537 PTGRCKICCSQYDKDGKKIRKETRYFCAECDVP------LCVVPCFEIYHTK 582


>gi|4885391 hyaluronan synthase 2 [Homo sapiens]
          Length = 552

 Score = 28.5 bits (62), Expect = 9.5
 Identities = 27/95 (28%), Positives = 41/95 (43%), Gaps = 18/95 (18%)

Query: 259 VMDVISRSQLYLDDLFSD---------------YYDKPLSMTDISLKEGTHIRVNLLNHN 303
           V+D  S   LY+ D+FS+               +++K    TD S KE +     L+  N
Sbjct: 119 VIDGNSEDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETDESHKESSQHVTQLVLSN 178

Query: 304 IPKGPCILCGMGNFKRETVYGCFQCSVDGQKYVRL 338
             K  CI+   G  KRE +Y  F+       YV++
Sbjct: 179 --KSICIMQKWGG-KREVMYTAFRALGRSVDYVQV 210


>gi|15619013 43 kD receptor-associated protein of the synapse
           isoform 1 [Homo sapiens]
          Length = 412

 Score = 28.5 bits (62), Expect = 9.5
 Identities = 23/94 (24%), Positives = 38/94 (40%), Gaps = 9/94 (9%)

Query: 258 RVMDVISRSQLYLDDLFSDYYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNF 317
           + +D I R+Q   +++ +      L     S+     ++  L  H +    C+       
Sbjct: 304 KALDAIERAQDLAEEVGNKLSQLKLHCLSESIYRSKGLQRELRAHVVRFHECV------- 356

Query: 318 KRETVYGCFQCSVD-GQKYVRLHAVPCFDIWHKR 350
             ET   C  C    G+K  RL A+PC  I+H R
Sbjct: 357 -EETELYCGLCGESIGEKNSRLQALPCSHIFHLR 389


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.139    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,132,505
Number of Sequences: 37866
Number of extensions: 497528
Number of successful extensions: 1123
Number of sequences better than 10.0: 11
Number of HSP's better than 10.0 without gapping: 8
Number of HSP's successfully gapped in prelim test: 3
Number of HSP's that attempted gapping in prelim test: 1111
Number of HSP's gapped (non-prelim): 11
length of query: 352
length of database: 18,247,518
effective HSP length: 103
effective length of query: 249
effective length of database: 14,347,320
effective search space: 3572482680
effective search space used: 3572482680
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.