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Search of human proteins with 169203021
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169203021 PREDICTED: similar to Shank2E [Homo sapiens]
(385 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169203021 PREDICTED: similar to Shank2E [Homo sapiens] 789 0.0
gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1... 759 0.0
gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap... 474 e-134
gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 472 e-133
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 96 7e-20
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 96 7e-20
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 96 7e-20
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 96 7e-20
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 96 7e-20
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 94 3e-19
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 94 3e-19
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 94 3e-19
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 93 5e-19
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 91 1e-18
gi|157743284 ankyrin repeat domain 52 [Homo sapiens] 89 5e-18
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 86 4e-17
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 85 1e-16
gi|38327522 cardiac ankyrin repeat protein [Homo sapiens] 84 2e-16
gi|68131557 ankyrin repeat domain 28 [Homo sapiens] 83 4e-16
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 82 8e-16
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 79 5e-15
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 79 5e-15
gi|55742857 ankyrin repeat domain 6 [Homo sapiens] 79 5e-15
gi|55770876 notch4 preproprotein [Homo sapiens] 77 2e-14
gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens] 77 3e-14
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 75 1e-13
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 75 1e-13
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens] 74 2e-13
gi|30348954 mindbomb homolog 1 [Homo sapiens] 74 3e-13
gi|148833508 notch1 preproprotein [Homo sapiens] 73 4e-13
>gi|169203021 PREDICTED: similar to Shank2E [Homo sapiens]
Length = 385
Score = 789 bits (2037), Expect = 0.0
Identities = 385/385 (100%), Positives = 385/385 (100%)
Query: 1 MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR 60
MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR
Sbjct: 1 MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR 60
Query: 61 VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER 120
VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER
Sbjct: 61 VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER 120
Query: 121 LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT 180
LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT
Sbjct: 121 LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT 180
Query: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR
Sbjct: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
Query: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH
Sbjct: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
Query: 301 EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK 360
EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK
Sbjct: 301 EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK 360
Query: 361 NYNSQTPFQVKEISASGRMCVDHSG 385
NYNSQTPFQVKEISASGRMCVDHSG
Sbjct: 361 NYNSQTPFQVKEISASGRMCVDHSG 385
>gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1
[Homo sapiens]
Length = 1849
Score = 759 bits (1960), Expect = 0.0
Identities = 371/376 (98%), Positives = 373/376 (99%)
Query: 1 MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR 60
MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR
Sbjct: 1 MPRSPTSSEDEMAQSFSDYSVGSESDSSKEETIYDTIRATAEKPGGARTEESQGNTLVIR 60
Query: 61 VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER 120
VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER
Sbjct: 61 VVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGKFLDEER 120
Query: 121 LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT 180
LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT
Sbjct: 121 LLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKIT 180
Query: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR
Sbjct: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
Query: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH
Sbjct: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
Query: 301 EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK 360
EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK
Sbjct: 301 EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK 360
Query: 361 NYNSQTPFQVKEISAS 376
NYNSQTPFQV I+ +
Sbjct: 361 NYNSQTPFQVAIIAGN 376
>gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo
sapiens]
Length = 1747
Score = 474 bits (1221), Expect = e-134
Identities = 222/322 (68%), Positives = 266/322 (82%)
Query: 55 NTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGLFQPASNGRDGK 114
+ +V+RV I DLQQTKC+R +P A VW AKQR+LC L SL+D LNYGLFQP S GR GK
Sbjct: 7 SAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGK 66
Query: 115 FLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHR 174
FLDEERLL+EYP + +P LEFRYK+RVY Q +D+KQ AKLHTK NLKK MD++Q
Sbjct: 67 FLDEERLLQEYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLH 126
Query: 175 LVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTA 234
+K+ ++LD+GLDPNFHDP++GE PL+LAAQLD++ +++K LKNGGAHLDFR +DG+TA
Sbjct: 127 STDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLKNGGAHLDFRTRDGLTA 186
Query: 235 LHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCK 294
+H A R RN AL TLL+LGASPDYKDS GLTPLYH+A+ GGD CCELLLH+HA +
Sbjct: 187 VHCATRQRNAAALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGIT 246
Query: 295 DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354
DENGW EIHQACR+GHVQHLEHLLFYGADM AQNASGNTALHICALYNQ+SCARVLLFRG
Sbjct: 247 DENGWQEIHQACRFGHVQHLEHLLFYGADMGAQNASGNTALHICALYNQESCARVLLFRG 306
Query: 355 GNKELKNYNSQTPFQVKEISAS 376
N++++NYNSQT FQV I+ +
Sbjct: 307 ANRDVRNYNSQTAFQVAIIAGN 328
>gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo
sapiens]
Length = 2161
Score = 472 bits (1214), Expect = e-133
Identities = 238/393 (60%), Positives = 295/393 (75%), Gaps = 18/393 (4%)
Query: 1 MPRSPTSSEDEMAQSFSDYSVG-SESDSSKEETIYDTIRATAEKPGGAR----------- 48
M SP +SEDE S S+ G SESDSS + R T + GA
Sbjct: 1 MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGP-RGTRGQGSGAPGSLASVRGLQG 59
Query: 49 -----TEESQGNTLVIRVVIHDLQQTKCIRFNPDATVWVAKQRILCTLTQSLKDVLNYGL 103
+++ + +V R+ I DL QTKC+RFNPDAT+W AKQ++LC L++SL+DVLNYGL
Sbjct: 60 RSMSVPDDAHFSMMVFRIGIPDLHQTKCLRFNPDATIWTAKQQVLCALSESLQDVLNYGL 119
Query: 104 FQPASNGRDGKFLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTN 163
FQPA++GRD FL+EERLLREYPQ +GVP LEFRYK RVYKQ +LDEKQLAKLHTKT
Sbjct: 120 FQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTG 179
Query: 164 LKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAH 223
LKK ++++Q +K+ ++LD+GLDPN+HD ++GETPLTLAAQ + SVEVI+ L GGAH
Sbjct: 180 LKKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAH 239
Query: 224 LDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCEL 283
+DFRA+DGMTALHKAA AR+ +AL LL+LG SP+YKD GLTPL+HTA+VGGDP CCEL
Sbjct: 240 IDFRARDGMTALHKAACARHCLALTALLDLGGSPNYKDRRGLTPLFHTAMVGGDPRCCEL 299
Query: 284 LLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQ 343
LL A + DENGW EIHQAC+ GH QHLEHLLFYGA+ AQNASGNTALHICALYN+
Sbjct: 300 LLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNK 359
Query: 344 DSCARVLLFRGGNKELKNYNSQTPFQVKEISAS 376
++CAR+LL+RG +K++KN N QTPFQV I+ +
Sbjct: 360 ETCARILLYRGADKDVKNNNGQTPFQVAVIAGN 392
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 95.5 bits (236), Expect = 7e-20
Identities = 66/192 (34%), Positives = 97/192 (50%), Gaps = 3/192 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L RG PN + + ETPL +AA+ + EV K L A ++ +AKD T LH A
Sbjct: 453 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHT-EVAKYLLQNKAKVNAKAKDDQTPLHCA 510
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
AR + +K LLE A+P+ + G TPL H A G LL + A+ C + G
Sbjct: 511 ARIGHTNMVKLLLENNANPNLATTAGHTPL-HIAAREGHVETVLALLEKEASQACMTKKG 569
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+ +H A +YG V+ E LL A +A +G T LH+ +N ++LL RGG+
Sbjct: 570 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 629
Query: 359 LKNYNSQTPFQV 370
+N TP +
Sbjct: 630 SPAWNGYTPLHI 641
Score = 88.2 bits (217), Expect = 1e-17
Identities = 59/176 (33%), Positives = 89/176 (50%), Gaps = 2/176 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
+TG TPL +AA ++ + V + L N GA ++F ++G+T LH A+R N + ++ LL+ G
Sbjct: 237 KTGFTPLHIAAHYEN-LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 295
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + K LTPL H A G E+LL A + K +NG IH A + H+ +
Sbjct: 296 AQIETKTKDELTPL-HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 354
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL Y A++ T LH+ A A+VLL +G + N TP +
Sbjct: 355 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 410
Score = 79.7 bits (195), Expect = 4e-15
Identities = 64/222 (28%), Positives = 98/222 (44%), Gaps = 36/222 (16%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG NF P+ G TPL +A++ + + +++ L + GA ++ + KD +T LH AAR
Sbjct: 258 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 315
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHE-------------- 287
+ + LL+ GA K GL+P+ H A G C LLL
Sbjct: 316 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 374
Query: 288 -HATVCCKDE------------------NGWHEIHQACRYGHVQHLEHLLFYGADMSAQN 328
H C NG+ +H AC+ HV+ +E LL GA + A
Sbjct: 375 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 434
Query: 329 ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
SG T LH+ + + LL RG + + N +TP +
Sbjct: 435 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 476
Score = 76.3 bits (186), Expect = 4e-14
Identities = 62/204 (30%), Positives = 90/204 (44%), Gaps = 5/204 (2%)
Query: 167 CMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDF 226
C I H + K+ +L+ +PN G TPL +AA+ + VE + AL A
Sbjct: 509 CAARIGHTNMVKL--LLENNANPNLATT-AGHTPLHIAAR-EGHVETVLALLEKEASQAC 564
Query: 227 RAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH 286
K G T LH AA+ + LLE A P+ GLTPL H A+ + +LLL
Sbjct: 565 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLP 623
Query: 287 EHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSC 346
+ NG+ +H A + V+ LL YG +A++ G T LH+ A
Sbjct: 624 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 683
Query: 347 ARVLLFRGGNKELKNYNSQTPFQV 370
+LL + N L N + TP +
Sbjct: 684 VALLLSKQANGNLGNKSGLTPLHL 707
Score = 75.9 bits (185), Expect = 6e-14
Identities = 65/216 (30%), Positives = 97/216 (44%), Gaps = 9/216 (4%)
Query: 156 AKLHTKTNLK----KCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSV 211
A++ TKT + C H + +I +LD G P + G +P+ +AAQ D +
Sbjct: 296 AQIETKTKDELTPLHCAARNGHVRISEI--LLDHGA-PIQAKTKNGLSPIHMAAQ-GDHL 351
Query: 212 EVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHT 271
+ ++ L A +D D +T LH AA + K LL+ GA P+ + G TPL H
Sbjct: 352 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL-HI 410
Query: 272 AIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASG 331
A ELLL A++ E+G +H A GH+ +++LL GA + N
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
Query: 332 NTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
T LH+ A A+ LL K + QTP
Sbjct: 471 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 506
Score = 73.9 bits (180), Expect = 2e-13
Identities = 56/201 (27%), Positives = 96/201 (47%), Gaps = 5/201 (2%)
Query: 171 IQHRLVEKITKMLDRGLDPNFHDPE-TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
+ H ++ + +L RG P H P G TPL +AA+ + VEV ++L G + +
Sbjct: 610 VHHNNLDIVKLLLPRGGSP--HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESV 666
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G+T LH AA+ + + LL A+ + + GLTPL+ A G P ++L+
Sbjct: 667 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-DVLIKHGV 725
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V G+ +H A YG+++ ++ LL + AD++A+ G + LH A +
Sbjct: 726 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 785
Query: 350 LLFRGGNKELKNYNSQTPFQV 370
LL G + + + TP +
Sbjct: 786 LLKNGASPNEVSSDGTTPLAI 806
Score = 62.8 bits (151), Expect = 5e-10
Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 7/191 (3%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + ++++ G + N + G TPL +AAQ ++ +EV+K L GA+ + +DG T L
Sbjct: 125 EVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLA 182
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + ++ + L+ G + P H A D +LL +
Sbjct: 183 VALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G+ +H A Y ++ + LL GA ++ +G T LHI + R+LL RG
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297
Query: 357 KELKNYNSQTP 367
E K + TP
Sbjct: 298 IETKTKDELTP 308
Score = 62.0 bits (149), Expect = 9e-10
Identities = 54/175 (30%), Positives = 77/175 (44%), Gaps = 3/175 (1%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
VE +L G N + G TPL LAAQ + E++ L + A+ + K G+T L
Sbjct: 648 VEVARSLLQYGGSANAESVQ-GVTPLHLAAQ-EGHAEMVALLLSKQANGNLGNKSGLTPL 705
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A+ + L++ G D G TPL H A G+ + LL A V K
Sbjct: 706 HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL-HVASHYGNIKLVKFLLQHQADVNAKT 764
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVL 350
+ G+ +HQA + GH + LL GA + ++ G T L I S VL
Sbjct: 765 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 58.5 bits (140), Expect = 1e-08
Identities = 62/237 (26%), Positives = 99/237 (41%), Gaps = 44/237 (18%)
Query: 163 NLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGA 222
NL K +DH+++ G+D N + + G L LA++ + V+++ L +
Sbjct: 57 NLDKALDHLRN------------GVDINTCN-QNGLNGLHLASK-EGHVKMVVELLHKEI 102
Query: 223 HLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCE 282
L+ K G TALH AA A ++ L+ GA+ + + G TPLY A +
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLY-MAAQENHLEVVK 161
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGA---------DMSAQN----- 328
LL A E+G+ + A + GH + HL+ YG ++A+N
Sbjct: 162 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 221
Query: 329 ---------------ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
+G T LHI A Y + A++LL RG + N TP +
Sbjct: 222 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 278
Score = 46.2 bits (108), Expect = 5e-05
Identities = 39/141 (27%), Positives = 61/141 (43%), Gaps = 1/141 (0%)
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
D T+ +AAR+ N L G + + GL L H A G LLH+
Sbjct: 44 DAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGL-HLASKEGHVKMVVELLHKEI 102
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
+ + G +H A G + + L+ YGA+++AQ+ G T L++ A N +
Sbjct: 103 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKF 162
Query: 350 LLFRGGNKELKNYNSQTPFQV 370
LL G N+ + + TP V
Sbjct: 163 LLENGANQNVATEDGFTPLAV 183
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 95.5 bits (236), Expect = 7e-20
Identities = 66/192 (34%), Positives = 97/192 (50%), Gaps = 3/192 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L RG PN + + ETPL +AA+ + EV K L A ++ +AKD T LH A
Sbjct: 420 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHT-EVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
AR + +K LLE A+P+ + G TPL H A G LL + A+ C + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPL-HIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+ +H A +YG V+ E LL A +A +G T LH+ +N ++LL RGG+
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 359 LKNYNSQTPFQV 370
+N TP +
Sbjct: 597 SPAWNGYTPLHI 608
Score = 88.2 bits (217), Expect = 1e-17
Identities = 59/176 (33%), Positives = 89/176 (50%), Gaps = 2/176 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
+TG TPL +AA ++ + V + L N GA ++F ++G+T LH A+R N + ++ LL+ G
Sbjct: 204 KTGFTPLHIAAHYEN-LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + K LTPL H A G E+LL A + K +NG IH A + H+ +
Sbjct: 263 AQIETKTKDELTPL-HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL Y A++ T LH+ A A+VLL +G + N TP +
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 79.7 bits (195), Expect = 4e-15
Identities = 64/222 (28%), Positives = 98/222 (44%), Gaps = 36/222 (16%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG NF P+ G TPL +A++ + + +++ L + GA ++ + KD +T LH AAR
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHE-------------- 287
+ + LL+ GA K GL+P+ H A G C LLL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 288 -HATVCCKDE------------------NGWHEIHQACRYGHVQHLEHLLFYGADMSAQN 328
H C NG+ +H AC+ HV+ +E LL GA + A
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 329 ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
SG T LH+ + + LL RG + + N +TP +
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Score = 76.3 bits (186), Expect = 4e-14
Identities = 62/204 (30%), Positives = 90/204 (44%), Gaps = 5/204 (2%)
Query: 167 CMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDF 226
C I H + K+ +L+ +PN G TPL +AA+ + VE + AL A
Sbjct: 476 CAARIGHTNMVKL--LLENNANPNLATT-AGHTPLHIAAR-EGHVETVLALLEKEASQAC 531
Query: 227 RAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH 286
K G T LH AA+ + LLE A P+ GLTPL H A+ + +LLL
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLP 590
Query: 287 EHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSC 346
+ NG+ +H A + V+ LL YG +A++ G T LH+ A
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 347 ARVLLFRGGNKELKNYNSQTPFQV 370
+LL + N L N + TP +
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHL 674
Score = 75.9 bits (185), Expect = 6e-14
Identities = 65/216 (30%), Positives = 97/216 (44%), Gaps = 9/216 (4%)
Query: 156 AKLHTKTNLK----KCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSV 211
A++ TKT + C H + +I +LD G P + G +P+ +AAQ D +
Sbjct: 263 AQIETKTKDELTPLHCAARNGHVRISEI--LLDHGA-PIQAKTKNGLSPIHMAAQ-GDHL 318
Query: 212 EVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHT 271
+ ++ L A +D D +T LH AA + K LL+ GA P+ + G TPL H
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL-HI 377
Query: 272 AIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASG 331
A ELLL A++ E+G +H A GH+ +++LL GA + N
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 332 NTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
T LH+ A A+ LL K + QTP
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 73.9 bits (180), Expect = 2e-13
Identities = 56/201 (27%), Positives = 96/201 (47%), Gaps = 5/201 (2%)
Query: 171 IQHRLVEKITKMLDRGLDPNFHDPE-TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
+ H ++ + +L RG P H P G TPL +AA+ + VEV ++L G + +
Sbjct: 577 VHHNNLDIVKLLLPRGGSP--HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESV 633
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G+T LH AA+ + + LL A+ + + GLTPL+ A G P ++L+
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-DVLIKHGV 692
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V G+ +H A YG+++ ++ LL + AD++A+ G + LH A +
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 350 LLFRGGNKELKNYNSQTPFQV 370
LL G + + + TP +
Sbjct: 753 LLKNGASPNEVSSDGTTPLAI 773
Score = 62.8 bits (151), Expect = 5e-10
Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 7/191 (3%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + ++++ G + N + G TPL +AAQ ++ +EV+K L GA+ + +DG T L
Sbjct: 92 EVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + ++ + L+ G + P H A D +LL +
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G+ +H A Y ++ + LL GA ++ +G T LHI + R+LL RG
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 357 KELKNYNSQTP 367
E K + TP
Sbjct: 265 IETKTKDELTP 275
Score = 62.0 bits (149), Expect = 9e-10
Identities = 54/175 (30%), Positives = 77/175 (44%), Gaps = 3/175 (1%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
VE +L G N + G TPL LAAQ + E++ L + A+ + K G+T L
Sbjct: 615 VEVARSLLQYGGSANAESVQ-GVTPLHLAAQ-EGHAEMVALLLSKQANGNLGNKSGLTPL 672
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A+ + L++ G D G TPL H A G+ + LL A V K
Sbjct: 673 HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL-HVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVL 350
+ G+ +HQA + GH + LL GA + ++ G T L I S VL
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 58.5 bits (140), Expect = 1e-08
Identities = 62/237 (26%), Positives = 99/237 (41%), Gaps = 44/237 (18%)
Query: 163 NLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGA 222
NL K +DH+++ G+D N + + G L LA++ + V+++ L +
Sbjct: 24 NLDKALDHLRN------------GVDINTCN-QNGLNGLHLASK-EGHVKMVVELLHKEI 69
Query: 223 HLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCE 282
L+ K G TALH AA A ++ L+ GA+ + + G TPLY A +
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLY-MAAQENHLEVVK 128
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGA---------DMSAQN----- 328
LL A E+G+ + A + GH + HL+ YG ++A+N
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188
Query: 329 ---------------ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
+G T LHI A Y + A++LL RG + N TP +
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Score = 49.7 bits (117), Expect = 4e-06
Identities = 41/145 (28%), Positives = 63/145 (43%), Gaps = 1/145 (0%)
Query: 226 FRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLL 285
FR D T+ +AAR+ N L G + + GL L H A G LL
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGL-HLASKEGHVKMVVELL 65
Query: 286 HEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDS 345
H+ + + G +H A G + + L+ YGA+++AQ+ G T L++ A N
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 346 CARVLLFRGGNKELKNYNSQTPFQV 370
+ LL G N+ + + TP V
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAV 150
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 95.5 bits (236), Expect = 7e-20
Identities = 66/192 (34%), Positives = 97/192 (50%), Gaps = 3/192 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L RG PN + + ETPL +AA+ + EV K L A ++ +AKD T LH A
Sbjct: 420 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHT-EVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
AR + +K LLE A+P+ + G TPL H A G LL + A+ C + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPL-HIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+ +H A +YG V+ E LL A +A +G T LH+ +N ++LL RGG+
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 359 LKNYNSQTPFQV 370
+N TP +
Sbjct: 597 SPAWNGYTPLHI 608
Score = 88.2 bits (217), Expect = 1e-17
Identities = 59/176 (33%), Positives = 89/176 (50%), Gaps = 2/176 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
+TG TPL +AA ++ + V + L N GA ++F ++G+T LH A+R N + ++ LL+ G
Sbjct: 204 KTGFTPLHIAAHYEN-LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + K LTPL H A G E+LL A + K +NG IH A + H+ +
Sbjct: 263 AQIETKTKDELTPL-HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL Y A++ T LH+ A A+VLL +G + N TP +
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 79.7 bits (195), Expect = 4e-15
Identities = 64/222 (28%), Positives = 98/222 (44%), Gaps = 36/222 (16%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG NF P+ G TPL +A++ + + +++ L + GA ++ + KD +T LH AAR
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHE-------------- 287
+ + LL+ GA K GL+P+ H A G C LLL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 288 -HATVCCKDE------------------NGWHEIHQACRYGHVQHLEHLLFYGADMSAQN 328
H C NG+ +H AC+ HV+ +E LL GA + A
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 329 ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
SG T LH+ + + LL RG + + N +TP +
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Score = 76.3 bits (186), Expect = 4e-14
Identities = 62/204 (30%), Positives = 90/204 (44%), Gaps = 5/204 (2%)
Query: 167 CMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDF 226
C I H + K+ +L+ +PN G TPL +AA+ + VE + AL A
Sbjct: 476 CAARIGHTNMVKL--LLENNANPNLATT-AGHTPLHIAAR-EGHVETVLALLEKEASQAC 531
Query: 227 RAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH 286
K G T LH AA+ + LLE A P+ GLTPL H A+ + +LLL
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLP 590
Query: 287 EHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSC 346
+ NG+ +H A + V+ LL YG +A++ G T LH+ A
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 347 ARVLLFRGGNKELKNYNSQTPFQV 370
+LL + N L N + TP +
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHL 674
Score = 75.9 bits (185), Expect = 6e-14
Identities = 65/216 (30%), Positives = 97/216 (44%), Gaps = 9/216 (4%)
Query: 156 AKLHTKTNLK----KCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSV 211
A++ TKT + C H + +I +LD G P + G +P+ +AAQ D +
Sbjct: 263 AQIETKTKDELTPLHCAARNGHVRISEI--LLDHGA-PIQAKTKNGLSPIHMAAQ-GDHL 318
Query: 212 EVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHT 271
+ ++ L A +D D +T LH AA + K LL+ GA P+ + G TPL H
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL-HI 377
Query: 272 AIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASG 331
A ELLL A++ E+G +H A GH+ +++LL GA + N
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 332 NTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
T LH+ A A+ LL K + QTP
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 73.9 bits (180), Expect = 2e-13
Identities = 56/201 (27%), Positives = 96/201 (47%), Gaps = 5/201 (2%)
Query: 171 IQHRLVEKITKMLDRGLDPNFHDPE-TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
+ H ++ + +L RG P H P G TPL +AA+ + VEV ++L G + +
Sbjct: 577 VHHNNLDIVKLLLPRGGSP--HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESV 633
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G+T LH AA+ + + LL A+ + + GLTPL+ A G P ++L+
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-DVLIKHGV 692
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V G+ +H A YG+++ ++ LL + AD++A+ G + LH A +
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 350 LLFRGGNKELKNYNSQTPFQV 370
LL G + + + TP +
Sbjct: 753 LLKNGASPNEVSSDGTTPLAI 773
Score = 62.8 bits (151), Expect = 5e-10
Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 7/191 (3%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + ++++ G + N + G TPL +AAQ ++ +EV+K L GA+ + +DG T L
Sbjct: 92 EVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + ++ + L+ G + P H A D +LL +
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G+ +H A Y ++ + LL GA ++ +G T LHI + R+LL RG
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 357 KELKNYNSQTP 367
E K + TP
Sbjct: 265 IETKTKDELTP 275
Score = 62.0 bits (149), Expect = 9e-10
Identities = 54/175 (30%), Positives = 77/175 (44%), Gaps = 3/175 (1%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
VE +L G N + G TPL LAAQ + E++ L + A+ + K G+T L
Sbjct: 615 VEVARSLLQYGGSANAESVQ-GVTPLHLAAQ-EGHAEMVALLLSKQANGNLGNKSGLTPL 672
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A+ + L++ G D G TPL H A G+ + LL A V K
Sbjct: 673 HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL-HVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVL 350
+ G+ +HQA + GH + LL GA + ++ G T L I S VL
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 58.5 bits (140), Expect = 1e-08
Identities = 62/237 (26%), Positives = 99/237 (41%), Gaps = 44/237 (18%)
Query: 163 NLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGA 222
NL K +DH+++ G+D N + + G L LA++ + V+++ L +
Sbjct: 24 NLDKALDHLRN------------GVDINTCN-QNGLNGLHLASK-EGHVKMVVELLHKEI 69
Query: 223 HLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCE 282
L+ K G TALH AA A ++ L+ GA+ + + G TPLY A +
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLY-MAAQENHLEVVK 128
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGA---------DMSAQN----- 328
LL A E+G+ + A + GH + HL+ YG ++A+N
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188
Query: 329 ---------------ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
+G T LHI A Y + A++LL RG + N TP +
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Score = 49.7 bits (117), Expect = 4e-06
Identities = 41/145 (28%), Positives = 63/145 (43%), Gaps = 1/145 (0%)
Query: 226 FRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLL 285
FR D T+ +AAR+ N L G + + GL L H A G LL
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGL-HLASKEGHVKMVVELL 65
Query: 286 HEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDS 345
H+ + + G +H A G + + L+ YGA+++AQ+ G T L++ A N
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 346 CARVLLFRGGNKELKNYNSQTPFQV 370
+ LL G N+ + + TP V
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAV 150
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 95.5 bits (236), Expect = 7e-20
Identities = 66/192 (34%), Positives = 97/192 (50%), Gaps = 3/192 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L RG PN + + ETPL +AA+ + EV K L A ++ +AKD T LH A
Sbjct: 420 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHT-EVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
AR + +K LLE A+P+ + G TPL H A G LL + A+ C + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPL-HIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+ +H A +YG V+ E LL A +A +G T LH+ +N ++LL RGG+
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 359 LKNYNSQTPFQV 370
+N TP +
Sbjct: 597 SPAWNGYTPLHI 608
Score = 88.2 bits (217), Expect = 1e-17
Identities = 59/176 (33%), Positives = 89/176 (50%), Gaps = 2/176 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
+TG TPL +AA ++ + V + L N GA ++F ++G+T LH A+R N + ++ LL+ G
Sbjct: 204 KTGFTPLHIAAHYEN-LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + K LTPL H A G E+LL A + K +NG IH A + H+ +
Sbjct: 263 AQIETKTKDELTPL-HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL Y A++ T LH+ A A+VLL +G + N TP +
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 79.7 bits (195), Expect = 4e-15
Identities = 64/222 (28%), Positives = 98/222 (44%), Gaps = 36/222 (16%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG NF P+ G TPL +A++ + + +++ L + GA ++ + KD +T LH AAR
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHE-------------- 287
+ + LL+ GA K GL+P+ H A G C LLL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 288 -HATVCCKDE------------------NGWHEIHQACRYGHVQHLEHLLFYGADMSAQN 328
H C NG+ +H AC+ HV+ +E LL GA + A
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 329 ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
SG T LH+ + + LL RG + + N +TP +
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Score = 76.3 bits (186), Expect = 4e-14
Identities = 62/204 (30%), Positives = 90/204 (44%), Gaps = 5/204 (2%)
Query: 167 CMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDF 226
C I H + K+ +L+ +PN G TPL +AA+ + VE + AL A
Sbjct: 476 CAARIGHTNMVKL--LLENNANPNLATT-AGHTPLHIAAR-EGHVETVLALLEKEASQAC 531
Query: 227 RAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH 286
K G T LH AA+ + LLE A P+ GLTPL H A+ + +LLL
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLP 590
Query: 287 EHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSC 346
+ NG+ +H A + V+ LL YG +A++ G T LH+ A
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 347 ARVLLFRGGNKELKNYNSQTPFQV 370
+LL + N L N + TP +
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHL 674
Score = 75.9 bits (185), Expect = 6e-14
Identities = 65/216 (30%), Positives = 97/216 (44%), Gaps = 9/216 (4%)
Query: 156 AKLHTKTNLK----KCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSV 211
A++ TKT + C H + +I +LD G P + G +P+ +AAQ D +
Sbjct: 263 AQIETKTKDELTPLHCAARNGHVRISEI--LLDHGA-PIQAKTKNGLSPIHMAAQ-GDHL 318
Query: 212 EVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHT 271
+ ++ L A +D D +T LH AA + K LL+ GA P+ + G TPL H
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL-HI 377
Query: 272 AIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASG 331
A ELLL A++ E+G +H A GH+ +++LL GA + N
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 332 NTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
T LH+ A A+ LL K + QTP
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 73.9 bits (180), Expect = 2e-13
Identities = 56/201 (27%), Positives = 96/201 (47%), Gaps = 5/201 (2%)
Query: 171 IQHRLVEKITKMLDRGLDPNFHDPE-TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
+ H ++ + +L RG P H P G TPL +AA+ + VEV ++L G + +
Sbjct: 577 VHHNNLDIVKLLLPRGGSP--HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESV 633
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G+T LH AA+ + + LL A+ + + GLTPL+ A G P ++L+
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-DVLIKHGV 692
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V G+ +H A YG+++ ++ LL + AD++A+ G + LH A +
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 350 LLFRGGNKELKNYNSQTPFQV 370
LL G + + + TP +
Sbjct: 753 LLKNGASPNEVSSDGTTPLAI 773
Score = 62.8 bits (151), Expect = 5e-10
Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 7/191 (3%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + ++++ G + N + G TPL +AAQ ++ +EV+K L GA+ + +DG T L
Sbjct: 92 EVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + ++ + L+ G + P H A D +LL +
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G+ +H A Y ++ + LL GA ++ +G T LHI + R+LL RG
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 357 KELKNYNSQTP 367
E K + TP
Sbjct: 265 IETKTKDELTP 275
Score = 62.0 bits (149), Expect = 9e-10
Identities = 54/175 (30%), Positives = 77/175 (44%), Gaps = 3/175 (1%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
VE +L G N + G TPL LAAQ + E++ L + A+ + K G+T L
Sbjct: 615 VEVARSLLQYGGSANAESVQ-GVTPLHLAAQ-EGHAEMVALLLSKQANGNLGNKSGLTPL 672
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A+ + L++ G D G TPL H A G+ + LL A V K
Sbjct: 673 HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL-HVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVL 350
+ G+ +HQA + GH + LL GA + ++ G T L I S VL
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 58.5 bits (140), Expect = 1e-08
Identities = 62/237 (26%), Positives = 99/237 (41%), Gaps = 44/237 (18%)
Query: 163 NLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGA 222
NL K +DH+++ G+D N + + G L LA++ + V+++ L +
Sbjct: 24 NLDKALDHLRN------------GVDINTCN-QNGLNGLHLASK-EGHVKMVVELLHKEI 69
Query: 223 HLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCE 282
L+ K G TALH AA A ++ L+ GA+ + + G TPLY A +
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLY-MAAQENHLEVVK 128
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGA---------DMSAQN----- 328
LL A E+G+ + A + GH + HL+ YG ++A+N
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188
Query: 329 ---------------ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
+G T LHI A Y + A++LL RG + N TP +
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Score = 49.7 bits (117), Expect = 4e-06
Identities = 41/145 (28%), Positives = 63/145 (43%), Gaps = 1/145 (0%)
Query: 226 FRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLL 285
FR D T+ +AAR+ N L G + + GL L H A G LL
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGL-HLASKEGHVKMVVELL 65
Query: 286 HEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDS 345
H+ + + G +H A G + + L+ YGA+++AQ+ G T L++ A N
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 346 CARVLLFRGGNKELKNYNSQTPFQV 370
+ LL G N+ + + TP V
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAV 150
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 95.5 bits (236), Expect = 7e-20
Identities = 66/192 (34%), Positives = 97/192 (50%), Gaps = 3/192 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L RG PN + + ETPL +AA+ + EV K L A ++ +AKD T LH A
Sbjct: 420 VKNLLQRGASPNVSNVKV-ETPLHMAARAGHT-EVAKYLLQNKAKVNAKAKDDQTPLHCA 477
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
AR + +K LLE A+P+ + G TPL H A G LL + A+ C + G
Sbjct: 478 ARIGHTNMVKLLLENNANPNLATTAGHTPL-HIAAREGHVETVLALLEKEASQACMTKKG 536
Query: 299 WHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKE 358
+ +H A +YG V+ E LL A +A +G T LH+ +N ++LL RGG+
Sbjct: 537 FTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPH 596
Query: 359 LKNYNSQTPFQV 370
+N TP +
Sbjct: 597 SPAWNGYTPLHI 608
Score = 88.2 bits (217), Expect = 1e-17
Identities = 59/176 (33%), Positives = 89/176 (50%), Gaps = 2/176 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
+TG TPL +AA ++ + V + L N GA ++F ++G+T LH A+R N + ++ LL+ G
Sbjct: 204 KTGFTPLHIAAHYEN-LNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRG 262
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + K LTPL H A G E+LL A + K +NG IH A + H+ +
Sbjct: 263 AQIETKTKDELTPL-HCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCV 321
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL Y A++ T LH+ A A+VLL +G + N TP +
Sbjct: 322 RLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Score = 79.7 bits (195), Expect = 4e-15
Identities = 64/222 (28%), Positives = 98/222 (44%), Gaps = 36/222 (16%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG NF P+ G TPL +A++ + + +++ L + GA ++ + KD +T LH AAR
Sbjct: 225 LLNRGASVNF-TPQNGITPLHIASRRGNVI-MVRLLLDRGAQIETKTKDELTPLHCAARN 282
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHE-------------- 287
+ + LL+ GA K GL+P+ H A G C LLL
Sbjct: 283 GHVRISEILLDHGAPIQAKTKNGLSPI-HMAAQGDHLDCVRLLLQYDAEIDDITLDHLTP 341
Query: 288 -HATVCCKDE------------------NGWHEIHQACRYGHVQHLEHLLFYGADMSAQN 328
H C NG+ +H AC+ HV+ +E LL GA + A
Sbjct: 342 LHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVT 401
Query: 329 ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
SG T LH+ + + LL RG + + N +TP +
Sbjct: 402 ESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHM 443
Score = 76.3 bits (186), Expect = 4e-14
Identities = 62/204 (30%), Positives = 90/204 (44%), Gaps = 5/204 (2%)
Query: 167 CMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDF 226
C I H + K+ +L+ +PN G TPL +AA+ + VE + AL A
Sbjct: 476 CAARIGHTNMVKL--LLENNANPNLATT-AGHTPLHIAAR-EGHVETVLALLEKEASQAC 531
Query: 227 RAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH 286
K G T LH AA+ + LLE A P+ GLTPL H A+ + +LLL
Sbjct: 532 MTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPL-HVAVHHNNLDIVKLLLP 590
Query: 287 EHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSC 346
+ NG+ +H A + V+ LL YG +A++ G T LH+ A
Sbjct: 591 RGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Query: 347 ARVLLFRGGNKELKNYNSQTPFQV 370
+LL + N L N + TP +
Sbjct: 651 VALLLSKQANGNLGNKSGLTPLHL 674
Score = 75.9 bits (185), Expect = 6e-14
Identities = 65/216 (30%), Positives = 97/216 (44%), Gaps = 9/216 (4%)
Query: 156 AKLHTKTNLK----KCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSV 211
A++ TKT + C H + +I +LD G P + G +P+ +AAQ D +
Sbjct: 263 AQIETKTKDELTPLHCAARNGHVRISEI--LLDHGA-PIQAKTKNGLSPIHMAAQ-GDHL 318
Query: 212 EVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHT 271
+ ++ L A +D D +T LH AA + K LL+ GA P+ + G TPL H
Sbjct: 319 DCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPL-HI 377
Query: 272 AIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASG 331
A ELLL A++ E+G +H A GH+ +++LL GA + N
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 332 NTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
T LH+ A A+ LL K + QTP
Sbjct: 438 ETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTP 473
Score = 73.9 bits (180), Expect = 2e-13
Identities = 56/201 (27%), Positives = 96/201 (47%), Gaps = 5/201 (2%)
Query: 171 IQHRLVEKITKMLDRGLDPNFHDPE-TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAK 229
+ H ++ + +L RG P H P G TPL +AA+ + VEV ++L G + +
Sbjct: 577 VHHNNLDIVKLLLPRGGSP--HSPAWNGYTPLHIAAK-QNQVEVARSLLQYGGSANAESV 633
Query: 230 DGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHA 289
G+T LH AA+ + + LL A+ + + GLTPL+ A G P ++L+
Sbjct: 634 QGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA-DVLIKHGV 692
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V G+ +H A YG+++ ++ LL + AD++A+ G + LH A +
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 350 LLFRGGNKELKNYNSQTPFQV 370
LL G + + + TP +
Sbjct: 753 LLKNGASPNEVSSDGTTPLAI 773
Score = 62.8 bits (151), Expect = 5e-10
Identities = 51/191 (26%), Positives = 85/191 (44%), Gaps = 7/191 (3%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E + ++++ G + N + G TPL +AAQ ++ +EV+K L GA+ + +DG T L
Sbjct: 92 EVVRELVNYGANVNAQS-QKGFTPLYMAAQ-ENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + ++ + L+ G + P H A D +LL +
Sbjct: 150 VALQQGHENVVAHLINYGTKGKVR-----LPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G+ +H A Y ++ + LL GA ++ +G T LHI + R+LL RG
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264
Query: 357 KELKNYNSQTP 367
E K + TP
Sbjct: 265 IETKTKDELTP 275
Score = 62.0 bits (149), Expect = 9e-10
Identities = 54/175 (30%), Positives = 77/175 (44%), Gaps = 3/175 (1%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
VE +L G N + G TPL LAAQ + E++ L + A+ + K G+T L
Sbjct: 615 VEVARSLLQYGGSANAESVQ-GVTPLHLAAQ-EGHAEMVALLLSKQANGNLGNKSGLTPL 672
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A+ + L++ G D G TPL H A G+ + LL A V K
Sbjct: 673 HLVAQEGHVPVADVLIKHGVMVDATTRMGYTPL-HVASHYGNIKLVKFLLQHQADVNAKT 731
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVL 350
+ G+ +HQA + GH + LL GA + ++ G T L I S VL
Sbjct: 732 KLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 58.5 bits (140), Expect = 1e-08
Identities = 62/237 (26%), Positives = 99/237 (41%), Gaps = 44/237 (18%)
Query: 163 NLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGA 222
NL K +DH+++ G+D N + + G L LA++ + V+++ L +
Sbjct: 24 NLDKALDHLRN------------GVDINTCN-QNGLNGLHLASK-EGHVKMVVELLHKEI 69
Query: 223 HLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCE 282
L+ K G TALH AA A ++ L+ GA+ + + G TPLY A +
Sbjct: 70 ILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLY-MAAQENHLEVVK 128
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGA---------DMSAQN----- 328
LL A E+G+ + A + GH + HL+ YG ++A+N
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRT 188
Query: 329 ---------------ASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
+G T LHI A Y + A++LL RG + N TP +
Sbjct: 189 AAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHI 245
Score = 49.7 bits (117), Expect = 4e-06
Identities = 41/145 (28%), Positives = 63/145 (43%), Gaps = 1/145 (0%)
Query: 226 FRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLL 285
FR D T+ +AAR+ N L G + + GL L H A G LL
Sbjct: 7 FREADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGL-HLASKEGHVKMVVELL 65
Query: 286 HEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDS 345
H+ + + G +H A G + + L+ YGA+++AQ+ G T L++ A N
Sbjct: 66 HKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 346 CARVLLFRGGNKELKNYNSQTPFQV 370
+ LL G N+ + + TP V
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAV 150
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 93.6 bits (231), Expect = 3e-19
Identities = 62/176 (35%), Positives = 89/176 (50%), Gaps = 2/176 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
E+G TPL +AA + V V L N GA +DF A++G+T LH A++ N +K LL+ G
Sbjct: 210 ESGFTPLHIAAHYGN-VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 268
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
D K GLTPL H A G ELLL A + + +NG +H A + HV+ +
Sbjct: 269 GQIDAKTRDGLTPL-HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 327
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
+HLL + A + TALH+ A ++LL + N + N TP +
Sbjct: 328 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 383
Score = 79.7 bits (195), Expect = 4e-15
Identities = 65/189 (34%), Positives = 88/189 (46%), Gaps = 3/189 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG P + G +PL +AAQ D VE +K L A +D D +TALH AA
Sbjct: 297 LLERGA-PLLARTKNGLSPLHMAAQ-GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 354
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ K LL+ A+P+ + G TPL H A ELL+ A++ E+G
Sbjct: 355 GHYRVTKLLLDKRANPNARALNGFTPL-HIACKKNRIKVMELLVKYGASIQAITESGLTP 413
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
IH A GH+ + LL GA N G TALH+ A Q R LL G + +
Sbjct: 414 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 473
Query: 362 YNSQTPFQV 370
QTP +
Sbjct: 474 REEQTPLHI 482
Score = 79.0 bits (193), Expect = 7e-15
Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 3/189 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L G P+ + GET L +AA+ VEV++ L GA +D RA++ T LH A+R
Sbjct: 429 LLQNGASPDVTNIR-GETALHMAARAGQ-VEVVRCLLRNGALVDARAREEQTPLHIASRL 486
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
++ LL+ A PD + G TPL H + G +LL A + G+
Sbjct: 487 GKTEIVQLLLQHMAHPDAATTNGYTPL-HISAREGQVDVASVLLEAGAAHSLATKKGFTP 545
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A +YG + + LL A + +G T LH+ A Y+ A +LL +G +
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 605
Query: 362 YNSQTPFQV 370
N TP +
Sbjct: 606 KNGYTPLHI 614
Score = 78.2 bits (191), Expect = 1e-14
Identities = 63/251 (25%), Positives = 109/251 (43%), Gaps = 34/251 (13%)
Query: 148 ASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQL 207
A + K + T++ + V T +L+RG +F G TPL +A++
Sbjct: 197 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKR 255
Query: 208 DDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTP 267
++ ++K L + G +D + +DG+T LH AAR+ + ++ LLE GA + GL+P
Sbjct: 256 GNT-NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 314
Query: 268 LY--------------------------------HTAIVGGDPYCCELLLHEHATVCCKD 295
L+ H A G +LLL + A +
Sbjct: 315 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 374
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
NG+ +H AC+ ++ +E L+ YGA + A SG T +H+ A + +LL G
Sbjct: 375 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 434
Query: 356 NKELKNYNSQT 366
+ ++ N +T
Sbjct: 435 SPDVTNIRGET 445
Score = 77.4 bits (189), Expect = 2e-14
Identities = 54/156 (34%), Positives = 80/156 (51%), Gaps = 3/156 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+ G + N + G TPL LA+Q + +++ L + GA++ K G+T+LH AA+
Sbjct: 627 LLNYGAETNIVTKQ-GVTPLHLASQ-EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 684
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
L + GA D G TPL A G+ LL + A V K +NG+
Sbjct: 685 DKVNVADILTKHGADQDAHTKLGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTP 743
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHI 337
+HQA + GH + LL +GA +A A+GNTAL I
Sbjct: 744 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 779
Score = 73.6 bits (179), Expect = 3e-13
Identities = 58/174 (33%), Positives = 80/174 (45%), Gaps = 2/174 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL +AA+ S++V K L A D K+G+T LH AA NQ LLE GAS
Sbjct: 542 GFTPLHVAAKYG-SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 600
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
P G TPL H A LL+ A + G +H A + GH +
Sbjct: 601 PHATAKNGYTPL-HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTL 659
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL GA++ SG T+LH+ A ++ + A +L G +++ TP V
Sbjct: 660 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIV 713
Score = 72.8 bits (177), Expect = 5e-13
Identities = 56/173 (32%), Positives = 74/173 (42%), Gaps = 2/173 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
+ G TPL +AA D+ +V L GA AK+G T LH AA+ TLL G
Sbjct: 573 KNGLTPLHVAAHYDNQ-KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG 631
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + G+TPL H A G LLL + A + ++G +H A + V
Sbjct: 632 AETNIVTKQGVTPL-HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 690
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
+ L +GAD A G T L + Y LL +G N K N TP
Sbjct: 691 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 743
Score = 70.5 bits (171), Expect = 2e-12
Identities = 61/176 (34%), Positives = 78/176 (44%), Gaps = 2/176 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
E+G TP+ +AA + V+ L+NG A D G TALH AARA ++ LL G
Sbjct: 408 ESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 466
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A D + TPL H A G +LLL A NG+ +H + R G V
Sbjct: 467 ALVDARAREEQTPL-HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 525
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL GA S G T LH+ A Y A++LL R + N TP V
Sbjct: 526 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 581
Score = 70.1 bits (170), Expect = 3e-12
Identities = 53/189 (28%), Positives = 86/189 (45%), Gaps = 3/189 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L++G P+ + G TPL +AA+ + +++ L N GA + K G+T LH A++
Sbjct: 594 LLEKGASPHA-TAKNGYTPLHIAAK-KNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 651
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ + LL+ GA+ GLT L H A ++L A + G+
Sbjct: 652 GHTDMVTLLLDKGANIHMSTKSGLTSL-HLAAQEDKVNVADILTKHGADQDAHTKLGYTP 710
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+ AC YG+V+ + LL GA+++A+ +G T LH A VLL G
Sbjct: 711 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 770
Query: 362 YNSQTPFQV 370
N T +
Sbjct: 771 ANGNTALAI 779
Score = 60.8 bits (146), Expect = 2e-09
Identities = 58/207 (28%), Positives = 87/207 (42%), Gaps = 37/207 (17%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G T L +A+ L EV+K L GA+++ ++++G T L+ AA+ + +K LLE GA+
Sbjct: 76 GNTALHIAS-LAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 134
Query: 257 PDYKDSYGLTPL----------------------------YHTAIVGGDPYCCELLLH-- 286
G TPL H A D LLL
Sbjct: 135 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 194
Query: 287 EHATVCCK------DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICAL 340
+A V K E+G+ +H A YG+V LL GA + +G T LH+ +
Sbjct: 195 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 254
Query: 341 YNQDSCARVLLFRGGNKELKNYNSQTP 367
+ ++LL RGG + K + TP
Sbjct: 255 RGNTNMVKLLLDRGGQIDAKTRDGLTP 281
Score = 56.6 bits (135), Expect = 4e-08
Identities = 62/232 (26%), Positives = 96/232 (41%), Gaps = 40/232 (17%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
++K+ + L G+D N + + G L LAA+ + V +++ L G+ +D K G TAL
Sbjct: 23 LDKVVEYLKGGIDINTCN-QNGLNALHLAAK-EGHVGLVQELLGRGSSVDSATKKGNTAL 80
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A+ A +K L++ GA+ + + G TPLY A + LL A
Sbjct: 81 HIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY-MAAQENHIDVVKYLLENGANQSTAT 139
Query: 296 ENGWHEIHQACRYGHVQHLEHLL-------------------------------FYGADM 324
E+G+ + A + GH Q + LL + AD+
Sbjct: 140 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 199
Query: 325 SAQ------NASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
++ SG T LHI A Y + A +LL RG + N TP V
Sbjct: 200 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 251
Score = 43.5 bits (101), Expect = 3e-04
Identities = 43/167 (25%), Positives = 68/167 (40%), Gaps = 38/167 (22%)
Query: 204 AAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSY 263
A LD VE +K GG ++ ++G+ ALH AA+ + ++ LL G+S D
Sbjct: 20 AGNLDKVVEYLK----GGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75
Query: 264 GLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGAD 323
G T L H A + G ++L+ E GA+
Sbjct: 76 GNTAL-HIASLAGQAEVVKVLVKE---------------------------------GAN 101
Query: 324 MSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
++AQ+ +G T L++ A N + LL G N+ + TP V
Sbjct: 102 INAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAV 148
Score = 29.6 bits (65), Expect = 4.8
Identities = 17/76 (22%), Positives = 32/76 (42%)
Query: 304 QACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYN 363
+A R G++ + L G D++ N +G ALH+ A + LL RG + +
Sbjct: 16 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 75
Query: 364 SQTPFQVKEISASGRM 379
T + ++ +
Sbjct: 76 GNTALHIASLAGQAEV 91
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 93.6 bits (231), Expect = 3e-19
Identities = 62/176 (35%), Positives = 89/176 (50%), Gaps = 2/176 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
E+G TPL +AA + V V L N GA +DF A++G+T LH A++ N +K LL+ G
Sbjct: 231 ESGFTPLHIAAHYGN-VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
D K GLTPL H A G ELLL A + + +NG +H A + HV+ +
Sbjct: 290 GQIDAKTRDGLTPL-HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
+HLL + A + TALH+ A ++LL + N + N TP +
Sbjct: 349 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404
Score = 79.7 bits (195), Expect = 4e-15
Identities = 65/189 (34%), Positives = 88/189 (46%), Gaps = 3/189 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG P + G +PL +AAQ D VE +K L A +D D +TALH AA
Sbjct: 318 LLERGA-PLLARTKNGLSPLHMAAQ-GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ K LL+ A+P+ + G TPL H A ELL+ A++ E+G
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPL-HIACKKNRIKVMELLVKYGASIQAITESGLTP 434
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
IH A GH+ + LL GA N G TALH+ A Q R LL G + +
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
Query: 362 YNSQTPFQV 370
QTP +
Sbjct: 495 REEQTPLHI 503
Score = 79.0 bits (193), Expect = 7e-15
Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 3/189 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L G P+ + GET L +AA+ VEV++ L GA +D RA++ T LH A+R
Sbjct: 450 LLQNGASPDVTNIR-GETALHMAARAGQ-VEVVRCLLRNGALVDARAREEQTPLHIASRL 507
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
++ LL+ A PD + G TPL H + G +LL A + G+
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPL-HISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A +YG + + LL A + +G T LH+ A Y+ A +LL +G +
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 362 YNSQTPFQV 370
N TP +
Sbjct: 627 KNGYTPLHI 635
Score = 78.2 bits (191), Expect = 1e-14
Identities = 63/251 (25%), Positives = 109/251 (43%), Gaps = 34/251 (13%)
Query: 148 ASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQL 207
A + K + T++ + V T +L+RG +F G TPL +A++
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKR 276
Query: 208 DDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTP 267
++ ++K L + G +D + +DG+T LH AAR+ + ++ LLE GA + GL+P
Sbjct: 277 GNT-NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335
Query: 268 LY--------------------------------HTAIVGGDPYCCELLLHEHATVCCKD 295
L+ H A G +LLL + A +
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
NG+ +H AC+ ++ +E L+ YGA + A SG T +H+ A + +LL G
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 356 NKELKNYNSQT 366
+ ++ N +T
Sbjct: 456 SPDVTNIRGET 466
Score = 77.4 bits (189), Expect = 2e-14
Identities = 54/156 (34%), Positives = 80/156 (51%), Gaps = 3/156 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+ G + N + G TPL LA+Q + +++ L + GA++ K G+T+LH AA+
Sbjct: 648 LLNYGAETNIVTKQ-GVTPLHLASQ-EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
L + GA D G TPL A G+ LL + A V K +NG+
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHI 337
+HQA + GH + LL +GA +A A+GNTAL I
Sbjct: 765 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 800
Score = 73.6 bits (179), Expect = 3e-13
Identities = 58/174 (33%), Positives = 80/174 (45%), Gaps = 2/174 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL +AA+ S++V K L A D K+G+T LH AA NQ LLE GAS
Sbjct: 563 GFTPLHVAAKYG-SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
P G TPL H A LL+ A + G +H A + GH +
Sbjct: 622 PHATAKNGYTPL-HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTL 680
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL GA++ SG T+LH+ A ++ + A +L G +++ TP V
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIV 734
Score = 72.8 bits (177), Expect = 5e-13
Identities = 56/173 (32%), Positives = 74/173 (42%), Gaps = 2/173 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
+ G TPL +AA D+ +V L GA AK+G T LH AA+ TLL G
Sbjct: 594 KNGLTPLHVAAHYDNQ-KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG 652
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + G+TPL H A G LLL + A + ++G +H A + V
Sbjct: 653 AETNIVTKQGVTPL-HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
+ L +GAD A G T L + Y LL +G N K N TP
Sbjct: 712 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764
Score = 70.5 bits (171), Expect = 2e-12
Identities = 61/176 (34%), Positives = 78/176 (44%), Gaps = 2/176 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
E+G TP+ +AA + V+ L+NG A D G TALH AARA ++ LL G
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A D + TPL H A G +LLL A NG+ +H + R G V
Sbjct: 488 ALVDARAREEQTPL-HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL GA S G T LH+ A Y A++LL R + N TP V
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602
Score = 70.1 bits (170), Expect = 3e-12
Identities = 53/189 (28%), Positives = 86/189 (45%), Gaps = 3/189 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L++G P+ + G TPL +AA+ + +++ L N GA + K G+T LH A++
Sbjct: 615 LLEKGASPHA-TAKNGYTPLHIAAK-KNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ + LL+ GA+ GLT L H A ++L A + G+
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSL-HLAAQEDKVNVADILTKHGADQDAHTKLGYTP 731
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+ AC YG+V+ + LL GA+++A+ +G T LH A VLL G
Sbjct: 732 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791
Query: 362 YNSQTPFQV 370
N T +
Sbjct: 792 ANGNTALAI 800
Score = 60.8 bits (146), Expect = 2e-09
Identities = 58/207 (28%), Positives = 87/207 (42%), Gaps = 37/207 (17%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G T L +A+ L EV+K L GA+++ ++++G T L+ AA+ + +K LLE GA+
Sbjct: 97 GNTALHIAS-LAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 257 PDYKDSYGLTPL----------------------------YHTAIVGGDPYCCELLLH-- 286
G TPL H A D LLL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215
Query: 287 EHATVCCK------DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICAL 340
+A V K E+G+ +H A YG+V LL GA + +G T LH+ +
Sbjct: 216 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 275
Query: 341 YNQDSCARVLLFRGGNKELKNYNSQTP 367
+ ++LL RGG + K + TP
Sbjct: 276 RGNTNMVKLLLDRGGQIDAKTRDGLTP 302
Score = 56.6 bits (135), Expect = 4e-08
Identities = 62/232 (26%), Positives = 96/232 (41%), Gaps = 40/232 (17%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
++K+ + L G+D N + + G L LAA+ + V +++ L G+ +D K G TAL
Sbjct: 44 LDKVVEYLKGGIDINTCN-QNGLNALHLAAK-EGHVGLVQELLGRGSSVDSATKKGNTAL 101
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A+ A +K L++ GA+ + + G TPLY A + LL A
Sbjct: 102 HIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY-MAAQENHIDVVKYLLENGANQSTAT 160
Query: 296 ENGWHEIHQACRYGHVQHLEHLL-------------------------------FYGADM 324
E+G+ + A + GH Q + LL + AD+
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 220
Query: 325 SAQ------NASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
++ SG T LHI A Y + A +LL RG + N TP V
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 272
Score = 45.8 bits (107), Expect = 6e-05
Identities = 48/169 (28%), Positives = 74/169 (43%), Gaps = 7/169 (4%)
Query: 204 AAQLDDSVEVIKALKNGGAHLDFRAK--DGMTALHKAARARNQVALKTLLELGASPDYKD 261
AAQ DS E NG + R K D + +AARA N + L+ G + +
Sbjct: 6 AAQKSDSGEKF----NGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCN 61
Query: 262 SYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYG 321
GL L H A G + LL ++V + G +H A G + ++ L+ G
Sbjct: 62 QNGLNAL-HLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 322 ADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
A+++AQ+ +G T L++ A N + LL G N+ + TP V
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAV 169
Score = 29.6 bits (65), Expect = 4.8
Identities = 17/76 (22%), Positives = 32/76 (42%)
Query: 304 QACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYN 363
+A R G++ + L G D++ N +G ALH+ A + LL RG + +
Sbjct: 37 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 364 SQTPFQVKEISASGRM 379
T + ++ +
Sbjct: 97 GNTALHIASLAGQAEV 112
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 93.6 bits (231), Expect = 3e-19
Identities = 62/176 (35%), Positives = 89/176 (50%), Gaps = 2/176 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
E+G TPL +AA + V V L N GA +DF A++G+T LH A++ N +K LL+ G
Sbjct: 231 ESGFTPLHIAAHYGN-VNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRG 289
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
D K GLTPL H A G ELLL A + + +NG +H A + HV+ +
Sbjct: 290 GQIDAKTRDGLTPL-HCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECV 348
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
+HLL + A + TALH+ A ++LL + N + N TP +
Sbjct: 349 KHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404
Score = 79.7 bits (195), Expect = 4e-15
Identities = 65/189 (34%), Positives = 88/189 (46%), Gaps = 3/189 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+RG P + G +PL +AAQ D VE +K L A +D D +TALH AA
Sbjct: 318 LLERGA-PLLARTKNGLSPLHMAAQ-GDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHC 375
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ K LL+ A+P+ + G TPL H A ELL+ A++ E+G
Sbjct: 376 GHYRVTKLLLDKRANPNARALNGFTPL-HIACKKNRIKVMELLVKYGASIQAITESGLTP 434
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
IH A GH+ + LL GA N G TALH+ A Q R LL G + +
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARA 494
Query: 362 YNSQTPFQV 370
QTP +
Sbjct: 495 REEQTPLHI 503
Score = 79.0 bits (193), Expect = 7e-15
Identities = 58/189 (30%), Positives = 89/189 (47%), Gaps = 3/189 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L G P+ + GET L +AA+ VEV++ L GA +D RA++ T LH A+R
Sbjct: 450 LLQNGASPDVTNIR-GETALHMAARAGQ-VEVVRCLLRNGALVDARAREEQTPLHIASRL 507
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
++ LL+ A PD + G TPL H + G +LL A + G+
Sbjct: 508 GKTEIVQLLLQHMAHPDAATTNGYTPL-HISAREGQVDVASVLLEAGAAHSLATKKGFTP 566
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A +YG + + LL A + +G T LH+ A Y+ A +LL +G +
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATA 626
Query: 362 YNSQTPFQV 370
N TP +
Sbjct: 627 KNGYTPLHI 635
Score = 78.2 bits (191), Expect = 1e-14
Identities = 63/251 (25%), Positives = 109/251 (43%), Gaps = 34/251 (13%)
Query: 148 ASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQL 207
A + K + T++ + V T +L+RG +F G TPL +A++
Sbjct: 218 ADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDF-TARNGITPLHVASKR 276
Query: 208 DDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTP 267
++ ++K L + G +D + +DG+T LH AAR+ + ++ LLE GA + GL+P
Sbjct: 277 GNT-NMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSP 335
Query: 268 LY--------------------------------HTAIVGGDPYCCELLLHEHATVCCKD 295
L+ H A G +LLL + A +
Sbjct: 336 LHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARA 395
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
NG+ +H AC+ ++ +E L+ YGA + A SG T +H+ A + +LL G
Sbjct: 396 LNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGA 455
Query: 356 NKELKNYNSQT 366
+ ++ N +T
Sbjct: 456 SPDVTNIRGET 466
Score = 77.4 bits (189), Expect = 2e-14
Identities = 54/156 (34%), Positives = 80/156 (51%), Gaps = 3/156 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L+ G + N + G TPL LA+Q + +++ L + GA++ K G+T+LH AA+
Sbjct: 648 LLNYGAETNIVTKQ-GVTPLHLASQ-EGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQE 705
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
L + GA D G TPL A G+ LL + A V K +NG+
Sbjct: 706 DKVNVADILTKHGADQDAHTKLGYTPLI-VACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHI 337
+HQA + GH + LL +GA +A A+GNTAL I
Sbjct: 765 LHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAI 800
Score = 73.6 bits (179), Expect = 3e-13
Identities = 58/174 (33%), Positives = 80/174 (45%), Gaps = 2/174 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL +AA+ S++V K L A D K+G+T LH AA NQ LLE GAS
Sbjct: 563 GFTPLHVAAKYG-SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGAS 621
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
P G TPL H A LL+ A + G +H A + GH +
Sbjct: 622 PHATAKNGYTPL-HIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTL 680
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL GA++ SG T+LH+ A ++ + A +L G +++ TP V
Sbjct: 681 LLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIV 734
Score = 72.8 bits (177), Expect = 5e-13
Identities = 56/173 (32%), Positives = 74/173 (42%), Gaps = 2/173 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
+ G TPL +AA D+ +V L GA AK+G T LH AA+ TLL G
Sbjct: 594 KNGLTPLHVAAHYDNQ-KVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYG 652
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + G+TPL H A G LLL + A + ++G +H A + V
Sbjct: 653 AETNIVTKQGVTPL-HLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
+ L +GAD A G T L + Y LL +G N K N TP
Sbjct: 712 DILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTP 764
Score = 70.5 bits (171), Expect = 2e-12
Identities = 61/176 (34%), Positives = 78/176 (44%), Gaps = 2/176 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
E+G TP+ +AA + V+ L+NG A D G TALH AARA ++ LL G
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNG-ASPDVTNIRGETALHMAARAGQVEVVRCLLRNG 487
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A D + TPL H A G +LLL A NG+ +H + R G V
Sbjct: 488 ALVDARAREEQTPL-HIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVA 546
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL GA S G T LH+ A Y A++LL R + N TP V
Sbjct: 547 SVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHV 602
Score = 70.1 bits (170), Expect = 3e-12
Identities = 53/189 (28%), Positives = 86/189 (45%), Gaps = 3/189 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L++G P+ + G TPL +AA+ + +++ L N GA + K G+T LH A++
Sbjct: 615 LLEKGASPHA-TAKNGYTPLHIAAK-KNQMQIASTLLNYGAETNIVTKQGVTPLHLASQE 672
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ + LL+ GA+ GLT L H A ++L A + G+
Sbjct: 673 GHTDMVTLLLDKGANIHMSTKSGLTSL-HLAAQEDKVNVADILTKHGADQDAHTKLGYTP 731
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+ AC YG+V+ + LL GA+++A+ +G T LH A VLL G
Sbjct: 732 LIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATT 791
Query: 362 YNSQTPFQV 370
N T +
Sbjct: 792 ANGNTALAI 800
Score = 60.8 bits (146), Expect = 2e-09
Identities = 58/207 (28%), Positives = 87/207 (42%), Gaps = 37/207 (17%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G T L +A+ L EV+K L GA+++ ++++G T L+ AA+ + +K LLE GA+
Sbjct: 97 GNTALHIAS-LAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGAN 155
Query: 257 PDYKDSYGLTPL----------------------------YHTAIVGGDPYCCELLLH-- 286
G TPL H A D LLL
Sbjct: 156 QSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQND 215
Query: 287 EHATVCCK------DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICAL 340
+A V K E+G+ +H A YG+V LL GA + +G T LH+ +
Sbjct: 216 HNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASK 275
Query: 341 YNQDSCARVLLFRGGNKELKNYNSQTP 367
+ ++LL RGG + K + TP
Sbjct: 276 RGNTNMVKLLLDRGGQIDAKTRDGLTP 302
Score = 56.6 bits (135), Expect = 4e-08
Identities = 62/232 (26%), Positives = 96/232 (41%), Gaps = 40/232 (17%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
++K+ + L G+D N + + G L LAA+ + V +++ L G+ +D K G TAL
Sbjct: 44 LDKVVEYLKGGIDINTCN-QNGLNALHLAAK-EGHVGLVQELLGRGSSVDSATKKGNTAL 101
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A+ A +K L++ GA+ + + G TPLY A + LL A
Sbjct: 102 HIASLAGQAEVVKVLVKEGANINAQSQNGFTPLY-MAAQENHIDVVKYLLENGANQSTAT 160
Query: 296 ENGWHEIHQACRYGHVQHLEHLL-------------------------------FYGADM 324
E+G+ + A + GH Q + LL + AD+
Sbjct: 161 EDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADV 220
Query: 325 SAQ------NASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
++ SG T LHI A Y + A +LL RG + N TP V
Sbjct: 221 QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHV 272
Score = 45.8 bits (107), Expect = 6e-05
Identities = 48/169 (28%), Positives = 74/169 (43%), Gaps = 7/169 (4%)
Query: 204 AAQLDDSVEVIKALKNGGAHLDFRAK--DGMTALHKAARARNQVALKTLLELGASPDYKD 261
AAQ DS E NG + R K D + +AARA N + L+ G + +
Sbjct: 6 AAQKSDSGEKF----NGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCN 61
Query: 262 SYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYG 321
GL L H A G + LL ++V + G +H A G + ++ L+ G
Sbjct: 62 QNGLNAL-HLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEG 120
Query: 322 ADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
A+++AQ+ +G T L++ A N + LL G N+ + TP V
Sbjct: 121 ANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAV 169
Score = 29.6 bits (65), Expect = 4.8
Identities = 17/76 (22%), Positives = 32/76 (42%)
Query: 304 QACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYN 363
+A R G++ + L G D++ N +G ALH+ A + LL RG + +
Sbjct: 37 RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKK 96
Query: 364 SQTPFQVKEISASGRM 379
T + ++ +
Sbjct: 97 GNTALHIASLAGQAEV 112
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 92.8 bits (229), Expect = 5e-19
Identities = 64/195 (32%), Positives = 96/195 (49%), Gaps = 4/195 (2%)
Query: 177 EKITKML-DRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
E + ++L R DPN H+ E G+TPL +AA V ++K L + GA LD + ++ T L
Sbjct: 474 ENVARLLVSRQADPNLHEAE-GKTPLHVAAYFGH-VSLVKLLTSQGAELDAQQRNLRTPL 531
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A A++ LL+ GA PD D G PL HTA G C++LL A++
Sbjct: 532 HLAVERGKVRAIQHLLKSGAVPDALDQSGYGPL-HTAAARGKYLICKMLLRYGASLELPT 590
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
GW +H A GH++ + L A+M A A T LH+ A + +++ LL G
Sbjct: 591 HQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGA 650
Query: 356 NKELKNYNSQTPFQV 370
+ + TP +
Sbjct: 651 DPNAAEQSGWTPLHL 665
Score = 63.9 bits (154), Expect = 2e-10
Identities = 53/177 (29%), Positives = 75/177 (42%), Gaps = 4/177 (2%)
Query: 195 ETGETPLT-LAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLEL 253
E TPL L AQ SVE ++ L +D + G T L AA+ + LL
Sbjct: 360 ENKVTPLHFLVAQ--GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAH 417
Query: 254 GASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQH 313
GA + D G PL H A GD LLL A V ++ GW +H A +
Sbjct: 418 GADANRVDEDGWAPL-HFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENV 476
Query: 314 LEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
L+ AD + A G T LH+ A + S ++L +G + + N +TP +
Sbjct: 477 ARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHL 533
Score = 60.5 bits (145), Expect = 3e-09
Identities = 62/223 (27%), Positives = 98/223 (43%), Gaps = 9/223 (4%)
Query: 148 ASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQL 207
A LD +Q L T +L ++ V I +L G P+ D ++G PL AA
Sbjct: 518 AELDAQQ-RNLRTPLHLA-----VERGKVRAIQHLLKSGAVPDALD-QSGYGPLHTAAAR 570
Query: 208 DDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTP 267
+ + K L GA L+ G T LH AA + + L E A+ + TP
Sbjct: 571 GKYL-ICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTP 629
Query: 268 LYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQ 327
L H A G+ LL A +++GW +H A + + +LL + A++ A+
Sbjct: 630 L-HLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHAR 688
Query: 328 NASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
N G T H+ AL + +VL+ G ++++ S TP Q+
Sbjct: 689 NKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQL 731
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 91.3 bits (225), Expect = 1e-18
Identities = 72/241 (29%), Positives = 111/241 (46%), Gaps = 5/241 (2%)
Query: 132 GVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRL--VEKITKMLDRGLDP 189
G L KK K L K A + T H+ + V +++++ G P
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASP 459
Query: 190 NFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKT 249
N + GET L +AA+ EV++ L GA ++ +AKD T LH +AR ++
Sbjct: 460 NTTNVR-GETALHMAAR-SGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQ 517
Query: 250 LLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYG 309
LL+ GASP+ + G TPL+ +A G + LL H A++ + G+ +H A +YG
Sbjct: 518 LLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH-GASLSITTKKGFTPLHVAAKYG 576
Query: 310 HVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQ 369
++ LL A A SG T LH+ A Y+ A +LL +G + N TP
Sbjct: 577 KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLH 636
Query: 370 V 370
+
Sbjct: 637 I 637
Score = 87.8 bits (216), Expect = 1e-17
Identities = 63/194 (32%), Positives = 89/194 (45%), Gaps = 2/194 (1%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
E++ +ML P + G +PL +A Q D + ++ L +D D +TALH
Sbjct: 314 EQVVEMLLDRAAPILSKTKNGLSPLHMATQ-GDHLNCVQLLLQHNVPVDDVTNDYLTALH 372
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
AA + K LL+ A+P+ K G TPL H A ELLL A++ E
Sbjct: 373 VAAHCGHYKVAKVLLDKKANPNAKALNGFTPL-HIACKKNRIKVMELLLKHGASIQAVTE 431
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
+G IH A GHV + L+ +GA + N G TALH+ A Q R L+ G
Sbjct: 432 SGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQ 491
Query: 357 KELKNYNSQTPFQV 370
E K + QTP +
Sbjct: 492 VEAKAKDDQTPLHI 505
Score = 84.3 bits (207), Expect = 2e-16
Identities = 58/178 (32%), Positives = 86/178 (48%), Gaps = 2/178 (1%)
Query: 193 DPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLE 252
+ ++G TPL +AA + + V L N A +DF A++ +T LH A++ N +K LL+
Sbjct: 231 ESKSGFTPLHIAAHYGN-INVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD 289
Query: 253 LGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQ 312
GA D K GLTPL H G E+LL A + K +NG +H A + H+
Sbjct: 290 RGAKIDAKTRDGLTPL-HCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLN 348
Query: 313 HLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
++ LL + + TALH+ A A+VLL + N K N TP +
Sbjct: 349 CVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406
Score = 82.8 bits (203), Expect = 5e-16
Identities = 65/203 (32%), Positives = 93/203 (45%), Gaps = 5/203 (2%)
Query: 170 HIQHRL--VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFR 227
HI RL + + ++L +G PN +G TPL L+A+ + +V L + GA L
Sbjct: 504 HISARLGKADIVQQLLQQGASPNAATT-SGYTPLHLSAR-EGHEDVAAFLLDHGASLSIT 561
Query: 228 AKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHE 287
K G T LH AA+ LL+ ASPD GLTPL H A + LLL +
Sbjct: 562 TKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPL-HVAAHYDNQKVALLLLDQ 620
Query: 288 HATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCA 347
A+ +NG+ +H A + + LL YGAD +A G ++H+ A
Sbjct: 621 GASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMV 680
Query: 348 RVLLFRGGNKELKNYNSQTPFQV 370
+LL R N L N + TP +
Sbjct: 681 SLLLGRNANVNLSNKSGLTPLHL 703
Score = 75.5 bits (184), Expect = 8e-14
Identities = 61/189 (32%), Positives = 84/189 (44%), Gaps = 3/189 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+LD G + + G TPL +AA+ +EV L A D K G+T LH AA
Sbjct: 551 LLDHGASLSI-TTKKGFTPLHVAAKYG-KLEVANLLLQKSASPDAAGKSGLTPLHVAAHY 608
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
NQ LL+ GASP G TPL H A LL A G
Sbjct: 609 DNQKVALLLLDQGASPHAAAKNGYTPL-HIAAKKNQMDIATTLLEYGADANAVTRQGIAS 667
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A + GHV + LL A+++ N SG T LH+ A ++ + A VL+ +G + + +
Sbjct: 668 VHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQT 727
Query: 362 YNSQTPFQV 370
TP V
Sbjct: 728 KMGYTPLHV 736
Score = 68.9 bits (167), Expect = 7e-12
Identities = 55/173 (31%), Positives = 75/173 (43%), Gaps = 2/173 (1%)
Query: 195 ETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
++G TPL +AA D+ +V L + GA AK+G T LH AA+ TLLE G
Sbjct: 596 KSGLTPLHVAAHYDNQ-KVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYG 654
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHL 314
A + G+ + H A G LLL +A V +++G +H A + V
Sbjct: 655 ADANAVTRQGIASV-HLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVA 713
Query: 315 EHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
E L+ GA + AQ G T LH+ Y LL K N TP
Sbjct: 714 EVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTP 766
Score = 68.6 bits (166), Expect = 9e-12
Identities = 50/185 (27%), Positives = 89/185 (48%), Gaps = 3/185 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+LD+G P+ + G TPL +AA+ + +++ L GA + + G+ ++H AA+
Sbjct: 617 LLDQGASPHAA-AKNGYTPLHIAAK-KNQMDIATTLLEYGADANAVTRQGIASVHLAAQE 674
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ + LL A+ + + GLTPL H A E+L+++ A V + + G+
Sbjct: 675 GHVDMVSLLLGRNANVNLSNKSGLTPL-HLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTP 733
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H C YG+++ + LL + A ++A+ +G T LH A VLL +
Sbjct: 734 LHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELT 793
Query: 362 YNSQT 366
N T
Sbjct: 794 VNGNT 798
Score = 68.2 bits (165), Expect = 1e-11
Identities = 51/158 (32%), Positives = 75/158 (47%), Gaps = 3/158 (1%)
Query: 180 TKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAA 239
T +L+ G D N + G + LAAQ + V+++ L A+++ K G+T LH AA
Sbjct: 648 TTLLEYGADANAVTRQ-GIASVHLAAQ-EGHVDMVSLLLGRNANVNLSNKSGLTPLHLAA 705
Query: 240 RARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGW 299
+ + L+ GA D + G TPL H G+ LL A V K +NG+
Sbjct: 706 QEDRVNVAEVLVNQGAHVDAQTKMGYTPL-HVGCHYGNIKIVNFLLQHSAKVNAKTKNGY 764
Query: 300 HEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHI 337
+HQA + GH + LL A + +GNTAL I
Sbjct: 765 TPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGI 802
Score = 64.3 bits (155), Expect = 2e-10
Identities = 68/267 (25%), Positives = 114/267 (42%), Gaps = 35/267 (13%)
Query: 141 KKRVYKQASLDEKQLAKLHTKT-------NLKKCMDHIQHRL------------------ 175
KKR +++ S D K+ + + +L+K +D+I++ +
Sbjct: 24 KKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASK 83
Query: 176 ---VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGM 232
VE ++++L R + + + G T L +A+ L EV+K L GA+++ ++++G
Sbjct: 84 EGHVEVVSELLQREANVDAATKK-GNTALHIAS-LAGQAEVVKVLVTNGANVNAQSQNGF 141
Query: 233 TALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVC 292
T L+ AA+ + +K LL+ GAS G TPL A+ G LLL
Sbjct: 142 TPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPL-AVALQQGHDQVVSLLLENDT--- 197
Query: 293 CKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLF 352
K + +H A R + LL + ++ SG T LHI A Y + A +LL
Sbjct: 198 -KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256
Query: 353 RGGNKELKNYNSQTPFQVKEISASGRM 379
R + N TP V + M
Sbjct: 257 RAAAVDFTARNDITPLHVASKRGNANM 283
Score = 60.1 bits (144), Expect = 3e-09
Identities = 47/142 (33%), Positives = 71/142 (50%), Gaps = 3/142 (2%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
V+ ++ +L R + N + ++G TPL LAAQ +D V V + L N GAH+D + K G T L
Sbjct: 677 VDMVSLLLGRNANVNLSN-KSGLTPLHLAAQ-EDRVNVAEVLVNQGAHVDAQTKMGYTPL 734
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H N + LL+ A + K G TPL H A G + +LL +A+
Sbjct: 735 HVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPL-HQAAQQGHTHIINVLLQNNASPNELT 793
Query: 296 ENGWHEIHQACRYGHVQHLEHL 317
NG + A R G++ ++ L
Sbjct: 794 VNGNTALGIARRLGYISVVDTL 815
>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
Length = 1076
Score = 89.4 bits (220), Expect = 5e-18
Identities = 63/201 (31%), Positives = 100/201 (49%), Gaps = 3/201 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L D N D + +TPL +AA + + + +AL + L+ + G +ALH A +
Sbjct: 93 LLAHSADVNARD-KLWQTPLHVAAA-NRATKCAEALAPLLSSLNVADRSGRSALHHAVHS 150
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ + LL GAS + D PL+ A +G +LL+ A + CKD G+
Sbjct: 151 GHLETVNLLLNKGASLNVCDKKERQPLHWAAFLG-HLEVLKLLVARGADLGCKDRKGYGL 209
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A G ++ +++LL GA++ NA GNTALHI QD+ A L+ G N N
Sbjct: 210 LHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPN 269
Query: 362 YNSQTPFQVKEISASGRMCVD 382
TP V +S +G +C++
Sbjct: 270 DKGFTPLHVAAVSTNGALCLE 290
Score = 72.4 bits (176), Expect = 6e-13
Identities = 52/205 (25%), Positives = 86/205 (41%), Gaps = 2/205 (0%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
+E + ++ RG D D + T AA +EV+K L GA +D G TAL
Sbjct: 186 LEVLKLLVARGADLGCKDRKGYGLLHTAAAS--GQIEVVKYLLRMGAEIDEPNAFGNTAL 243
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A L+ GA+ + + G TPL+ A+ C ELL++ A V +
Sbjct: 244 HIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGADVNYQS 303
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
+ G +H A +G + L+ G+++ + GNT LH+ A Y + L+ G
Sbjct: 304 KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363
Query: 356 NKELKNYNSQTPFQVKEISASGRMC 380
+ + + P + + C
Sbjct: 364 DTARRGIHDMFPLHLAVLFGFSDCC 388
Score = 71.2 bits (173), Expect = 1e-12
Identities = 50/159 (31%), Positives = 76/159 (47%), Gaps = 3/159 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARN-QVALKTLLELGA 255
G T L +A L I+ L N GA+++ G T LH AA + N + L+ L+ GA
Sbjct: 239 GNTALHIACYLGQDAVAIE-LVNAGANVNQPNDKGFTPLHVAAVSTNGALCLELLVNNGA 297
Query: 256 SPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLE 315
+Y+ G +PL H A + G ++L+ + + C D+ G +H A RYGH +
Sbjct: 298 DVNYQSKEGKSPL-HMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLIS 356
Query: 316 HLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354
L+ GAD + + LH+ L+ C R LL G
Sbjct: 357 TLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395
Score = 67.4 bits (163), Expect = 2e-11
Identities = 61/221 (27%), Positives = 94/221 (42%), Gaps = 21/221 (9%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+++ G D N+ E G++PL +AA + + L G+ +D K G T LH AAR
Sbjct: 292 LVNNGADVNYQSKE-GKSPLHMAA-IHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARY 349
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLL-------------HEH 288
+++ + TL+ GA + + + PL H A++ G CC LL +EH
Sbjct: 350 GHELLISTLMTNGADTARRGIHDMFPL-HLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEH 408
Query: 289 ATVCCKDEN-----GWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQ 343
D N G +H A G+V+ L LL GAD+ ++ G T LH A
Sbjct: 409 VLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGS 468
Query: 344 DSCARVLLFRGGNKELKNYNSQTPFQVKEISASGRMCVDHS 384
CA L+ G + +P S + R H+
Sbjct: 469 YQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAEPHT 509
Score = 56.6 bits (135), Expect = 4e-08
Identities = 54/190 (28%), Positives = 84/190 (44%), Gaps = 7/190 (3%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHL-DFRAKDGMTALHKAAR 240
+LD G DP+ D + G T + AA + + L+ L D + ++ LH AA
Sbjct: 536 LLDNGADPSLRDRQ-GYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAY 594
Query: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD-ENGW 299
+ ALKTL E + D +D G T L+ A G C E+L A+ K+ + W
Sbjct: 595 NGHCEALKTLAETLVNLDVRDHKGRTALF-LATERGSTECVEVLTAHGASALIKERKRKW 653
Query: 300 HEIHQACRYGHVQHLEHLLFYG--ADMS-AQNASGNTALHICALYNQDSCARVLLFRGGN 356
+H A GH L L+ G AD++ +A G T L + + C +LL +G
Sbjct: 654 TPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGST 713
Query: 357 KELKNYNSQT 366
+ + +T
Sbjct: 714 ADAADLRGRT 723
Score = 55.5 bits (132), Expect = 8e-08
Identities = 61/199 (30%), Positives = 82/199 (41%), Gaps = 9/199 (4%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L G D N D G T L AA +VE + L + GA L R K G T LH AA
Sbjct: 409 VLSAGFDINTPD-NLGRTCLHAAAS-GGNVECLNLLLSSGADLRRRDKFGRTPLHYAAAN 466
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ TL+ GA + D G +PL++ A D Y E T D
Sbjct: 467 GSYQCAVTLVTAGAGVNEADCKGCSPLHYAA--ASDTY----RRAEPHTPSSHDAEEDEP 520
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+ ++ R LE LL GAD S ++ G TA+H A Y +LL N L++
Sbjct: 521 LKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNLELLLEMSFNC-LED 579
Query: 362 YNSQTPFQVKEISASGRMC 380
S P ++A C
Sbjct: 580 VESTIPVSPLHLAAYNGHC 598
Score = 54.7 bits (130), Expect = 1e-07
Identities = 49/160 (30%), Positives = 73/160 (45%), Gaps = 8/160 (5%)
Query: 197 GETPLTLAAQLDDS--VEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELG 254
G T L LA + + VEV+ A +G + L K T LH AA + + +L L++ G
Sbjct: 618 GRTALFLATERGSTECVEVLTA--HGASALIKERKRKWTPLHAAAASGHTDSLHLLIDSG 675
Query: 255 ASPDYKD---SYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHV 311
D D +YG TPL AI+ G C LLL + +T D G +H+ G
Sbjct: 676 ERADITDVMDAYGQTPLM-LAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCE 734
Query: 312 QHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLL 351
L LL + A + ++ G T +H+ + + R LL
Sbjct: 735 DCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLL 774
Score = 51.6 bits (122), Expect = 1e-06
Identities = 57/195 (29%), Positives = 83/195 (42%), Gaps = 10/195 (5%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G+TPL LA ++ V+ + L G+ D G TALH+ A + L LL+ A
Sbjct: 688 GQTPLMLAI-MNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAF 746
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELL---LHEHATVCCKDENGWHEIHQACRYGHVQH 313
+D G TP++ + G LL L D +G+ +H A GH
Sbjct: 747 VLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDC 806
Query: 314 LEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNK--ELKNYNSQTPFQVK 371
LE LL + + S + T LH + NQDS +LL G K ++ +TP
Sbjct: 807 LELLLEH-SPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAA 865
Query: 372 EI--SASG-RMCVDH 383
+ SG RM + H
Sbjct: 866 AFADNVSGLRMLLQH 880
Score = 49.7 bits (117), Expect = 4e-06
Identities = 53/186 (28%), Positives = 74/186 (39%), Gaps = 6/186 (3%)
Query: 199 TPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPD 258
+PL LAA + E +K L +LD R G TAL A + ++ L GAS
Sbjct: 587 SPLHLAAY-NGHCEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASAL 645
Query: 259 YKDSYGLTPLYHTAIVGGDPYCCELLLH--EHATVC-CKDENGWHEIHQACRYGHVQHLE 315
K+ H A G LL+ E A + D G + A GHV +
Sbjct: 646 IKERKRKWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVH 705
Query: 316 HLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVKEISA 375
LL G+ A + G TALH A+ + C LL +++ +TP + SA
Sbjct: 706 LLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHL--ASA 763
Query: 376 SGRMCV 381
G V
Sbjct: 764 CGHTAV 769
Score = 49.3 bits (116), Expect = 6e-06
Identities = 51/202 (25%), Positives = 81/202 (40%), Gaps = 36/202 (17%)
Query: 196 TGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGA 255
T + PL A D VE +++L + +++ ++ T LH AA + L+ LL GA
Sbjct: 7 TDQPPLVQAIFSRD-VEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGA 65
Query: 256 SPDYKDSYGLTPLYHTAIVGGDPYCCELLLH--------------------EHATVCCK- 294
+ + KD+ LTPL+ A + LL H AT C +
Sbjct: 66 NVNAKDTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEA 125
Query: 295 -----------DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQ 343
D +G +H A GH++ + LL GA ++ + LH A
Sbjct: 126 LAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGH 185
Query: 344 DSCARVLLFRG---GNKELKNY 362
++L+ RG G K+ K Y
Sbjct: 186 LEVLKLLVARGADLGCKDRKGY 207
Score = 48.9 bits (115), Expect = 8e-06
Identities = 47/152 (30%), Positives = 62/152 (40%), Gaps = 5/152 (3%)
Query: 220 GGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPY 279
G ++ R G T LH AA A N L+ LL+ A + D G T L TA G
Sbjct: 847 GAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALM-TAAENGQTA 905
Query: 280 CCELLLHE-HATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNT---AL 335
E LL+ A + DEN +H AC GH + +L D+ NA+ + L
Sbjct: 906 AVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPL 965
Query: 336 HICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
HI A S + LL G + TP
Sbjct: 966 HIAARNGLASVVQALLSHGATVLAVDEEGHTP 997
Score = 32.7 bits (73), Expect = 0.57
Identities = 23/87 (26%), Positives = 38/87 (43%)
Query: 284 LLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQ 343
LL + + D+ +H A G V L+ LL GA+++A++ T LH A
Sbjct: 27 LLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRAAASRN 86
Query: 344 DSCARVLLFRGGNKELKNYNSQTPFQV 370
+ +LL + ++ QTP V
Sbjct: 87 EKVLGLLLAHSADVNARDKLWQTPLHV 113
Score = 30.0 bits (66), Expect = 3.7
Identities = 43/135 (31%), Positives = 56/135 (41%), Gaps = 8/135 (5%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
V + +L + N D TG T L AA+ + V L G A L ++ TAL
Sbjct: 871 VSGLRMLLQHQAEVNATD-HTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTAL 929
Query: 236 HKA-ARARNQVALKTLLE---LGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATV 291
H A ++ + AL L E LG + +S PL H A G + LL ATV
Sbjct: 930 HLACSKGHEKCALMILAETQDLGLI-NATNSALQMPL-HIAARNGLASVVQALLSHGATV 987
Query: 292 CCKDENGWHEIHQAC 306
DE G H AC
Sbjct: 988 LAVDEEG-HTPALAC 1001
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 86.3 bits (212), Expect = 4e-17
Identities = 78/286 (27%), Positives = 126/286 (44%), Gaps = 39/286 (13%)
Query: 126 PQPVGEGVPSLEFRYKKRVYKQA--SLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKML 183
P +G P L K + A +LD ++ KL + + K+ + ++K+ ML
Sbjct: 701 PAGLGRPTPGLSQGPGKETLESALIALDSEKPKKL--RFHPKQLYFSARQGELQKVLLML 758
Query: 184 DRGLDPNFH-DPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARAR 242
G+DPNF + + +PL AA+ V++ L GA++D ++D T L +AA
Sbjct: 759 VDGIDPNFKMEHQNKRSPLHAAAEA-GHVDICHMLVQAGANIDTCSEDQRTPLMEAAENN 817
Query: 243 NQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEI 302
+ A+K L++ GA D KD+ G T L+ A G LL + V C+D+ GW +
Sbjct: 818 HLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPM 877
Query: 303 HQACRYGHVQHLEHLLFYGADMS---------------------------------AQNA 329
A Y HV ++ LL G+D++ A N
Sbjct: 878 IWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNI 937
Query: 330 SGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVKEISA 375
G++ LHI A N+ C + L R + LKN +TP Q +++
Sbjct: 938 HGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLNS 983
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 85.1 bits (209), Expect = 1e-16
Identities = 65/229 (28%), Positives = 106/229 (46%), Gaps = 5/229 (2%)
Query: 156 AKLHTKTNLKKCMDH--IQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEV 213
A+++ K N+ H + R E + ++ D N D + +TPL +AA + +V+
Sbjct: 40 ARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHSADVNARD-KNWQTPLHVAAA-NKAVKC 97
Query: 214 IKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAI 273
+ + + ++ + G TALH AA + + LL GA+ + D L+ A
Sbjct: 98 AEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAY 157
Query: 274 VGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNT 333
+G LL++ A V CKD+ G+ +H A G + ++HLL G ++ N GNT
Sbjct: 158 MGHLDVVA-LLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNT 216
Query: 334 ALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVKEISASGRMCVD 382
ALHI QD+ L+ G N N N TP S G +C++
Sbjct: 217 ALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLE 265
Score = 77.8 bits (190), Expect = 2e-14
Identities = 52/205 (25%), Positives = 91/205 (44%), Gaps = 2/205 (0%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
++ + +++ G + D + G TPL AA + + V+K L N G +D G TAL
Sbjct: 161 LDVVALLINHGAEVTCKDKK-GYTPLHAAAS-NGQINVVKHLLNLGVEIDEINVYGNTAL 218
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A + L++ GA+ + ++ G TPL+ A C ELL++ A V +
Sbjct: 219 HIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVNIQS 278
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
++G +H +G + L+ G ++ + GNT LH+ A Y + L G
Sbjct: 279 KDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGA 338
Query: 356 NKELKNYNSQTPFQVKEISASGRMC 380
+ +S P + ++A C
Sbjct: 339 DTAKCGIHSMFPLHLAALNAHSDCC 363
Score = 72.4 bits (176), Expect = 6e-13
Identities = 54/180 (30%), Positives = 87/180 (48%), Gaps = 3/180 (1%)
Query: 188 DPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVAL 247
D N D E TPL +AA L D+ E+I+ L GA ++ + +T LH+A +R++ A+
Sbjct: 8 DVNTLDSEK-RTPLHVAAFLGDA-EIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAV 65
Query: 248 KTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACR 307
+ L++ A + +D TPL H A C E+++ ++V D G +H A
Sbjct: 66 QVLIKHSADVNARDKNWQTPL-HVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAAL 124
Query: 308 YGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
GHV+ + LL GA+++A + ALH A +L+ G K+ TP
Sbjct: 125 NGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTP 184
Score = 63.9 bits (154), Expect = 2e-10
Identities = 60/200 (30%), Positives = 84/200 (42%), Gaps = 31/200 (15%)
Query: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
K+L G + + D + G T L AA +VE IK L++ GA + K G T LH AA
Sbjct: 365 KLLSSGFEIDTPD-KFGRTCLHAAAA-GGNVECIKLLQSSGADFHKKDKCGRTPLHYAAA 422
Query: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGD----------------------- 277
+ ++TL+ GA+ + D +G T L++ A D
Sbjct: 423 NCHFHCIETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELK 482
Query: 278 ----PYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNT 333
C E LL A +D+ G++ IH A YGH Q LE LL ++ SG T
Sbjct: 483 EKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGAT 542
Query: 334 --ALHICALYNQDSCARVLL 351
LH+ A VLL
Sbjct: 543 KSPLHLAAYNGHHQALEVLL 562
Score = 63.2 bits (152), Expect = 4e-10
Identities = 64/233 (27%), Positives = 94/233 (40%), Gaps = 48/233 (20%)
Query: 160 TKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKN 219
TK+ L + H+ +E + + L +D + D E G T L LAA E ++AL N
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSL---VDLDIRD-EKGRTALDLAA-FKGHTECVEALIN 596
Query: 220 GGAHLDFRAKDGMTA---LHKAARARNQVALKTLLELGASP---DYKDSYGLTPLY---- 269
GA + KD +T LH + + + L+ LLE+ +P D KD+ G TPL
Sbjct: 597 PGASIF--VKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVA 654
Query: 270 ----------------------------HTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
H I+ G C ++LL + ++ CKD G
Sbjct: 655 YGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTP 714
Query: 302 IHQACRYGHVQHLEHLL---FYGADMSAQNASGNTALHICALYNQDSCARVLL 351
+H A GH L LL D ++ G T LH ++C VLL
Sbjct: 715 LHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLL 767
Score = 62.8 bits (151), Expect = 5e-10
Identities = 55/186 (29%), Positives = 83/186 (44%), Gaps = 8/186 (4%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL +AA+ + +I L+ GA M LH AA + + LL G
Sbjct: 314 GNTPLHVAARYGHEL-LINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFE 372
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
D D +G T L H A GG+ C +LL A KD+ G +H A H +E
Sbjct: 373 IDTPDKFGRTCL-HAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIET 431
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVKEISAS 376
L+ GA+++ + G TALH A + D +L GN + + ++KE A+
Sbjct: 432 LVTTGANVNETDDWGRTALHYAAASDMDRNKTIL----GNAHDNSEELERARELKEKEAT 487
Query: 377 GRMCVD 382
+C++
Sbjct: 488 --LCLE 491
Score = 62.8 bits (151), Expect = 5e-10
Identities = 52/182 (28%), Positives = 82/182 (45%), Gaps = 6/182 (3%)
Query: 191 FHDPETGET--PLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALK 248
F + ++G T PL LAA + + ++ L LD R + G TAL AA + ++
Sbjct: 534 FEESDSGATKSPLHLAAY-NGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVE 592
Query: 249 TLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH---EHATVCCKDENGWHEIHQA 305
L+ GAS KD+ H +++ G C LLL V KD G + A
Sbjct: 593 ALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLA 652
Query: 306 CRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQ 365
YGH+ + LL A++ + G TALH + + C ++LL + + K+ +
Sbjct: 653 VAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGR 712
Query: 366 TP 367
TP
Sbjct: 713 TP 714
Score = 60.8 bits (146), Expect = 2e-09
Identities = 50/159 (31%), Positives = 73/159 (45%), Gaps = 8/159 (5%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G+TPL LA ++ + L A++D G TALH+ ++ ++ LLE S
Sbjct: 645 GQTPLMLAVAYGH-IDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVS 703
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELL--LHEHATVCCKDENGWHEIHQACRYGHVQHL 314
KDS G TPL++ A G + ELL C KD G+ +H AC G+ +
Sbjct: 704 ILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCI 763
Query: 315 EHLLFYGADMSAQNASGN--TALHICALYNQDSCARVLL 351
E LL + GN T LH + + +CA +LL
Sbjct: 764 EVLL---EQKCFRKFIGNPFTPLHCAIINDHGNCASLLL 799
Score = 54.7 bits (130), Expect = 1e-07
Identities = 48/159 (30%), Positives = 74/159 (46%), Gaps = 6/159 (3%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLD--FRAKDGMTALHKAARARNQVALKTLLELG 254
G TPL AA + + + L+ + D F+ G T LH A N+ ++ LLE
Sbjct: 711 GRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQK 770
Query: 255 ASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH--EHATVCCKDENGWHEIHQACRYGHVQ 312
+ + TPL H AI+ C LLL + + V C+D+ G + A HV+
Sbjct: 771 CFRKFIGN-PFTPL-HCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVE 828
Query: 313 HLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLL 351
L+ LL + A ++A + SG TAL + A Q +L+
Sbjct: 829 CLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILV 867
Score = 53.5 bits (127), Expect = 3e-07
Identities = 47/163 (28%), Positives = 72/163 (44%), Gaps = 7/163 (4%)
Query: 214 IKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLT--PLYHT 271
++ L A+ R K+G ++H AA ++ L+ LLE S + G T PL H
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPL-HL 548
Query: 272 AIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQ-NAS 330
A G E+LL + +DE G + A GH + +E L+ GA + + N +
Sbjct: 549 AAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608
Query: 331 GNTALHICALYNQDSCARVLLFRGGNKE---LKNYNSQTPFQV 370
T LH + C R+LL N E +K+ QTP +
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLML 651
Score = 35.4 bits (80), Expect = 0.087
Identities = 22/88 (25%), Positives = 39/88 (44%)
Query: 283 LLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYN 342
+L+H+ V D +H A G + +E L+ GA ++A++ T LH
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 343 QDSCARVLLFRGGNKELKNYNSQTPFQV 370
+ +VL+ + ++ N QTP V
Sbjct: 61 SEEAVQVLIKHSADVNARDKNWQTPLHV 88
Score = 28.9 bits (63), Expect = 8.2
Identities = 26/84 (30%), Positives = 35/84 (41%)
Query: 227 RAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLH 286
R G T L AA A + L+ LL A + D+ G T L A G L+
Sbjct: 810 RDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVNS 869
Query: 287 EHATVCCKDENGWHEIHQACRYGH 310
A + KD++ +H AC GH
Sbjct: 870 AQADLTVKDKDLNTPLHLACSKGH 893
>gi|38327522 cardiac ankyrin repeat protein [Homo sapiens]
Length = 319
Score = 84.3 bits (207), Expect = 2e-16
Identities = 75/280 (26%), Positives = 130/280 (46%), Gaps = 23/280 (8%)
Query: 109 NGRDGKFLDEERLLREYPQPVG----EGVPSL--------EFRYKKRVYKQASLDEKQLA 156
NG G+FL E+ EY V E + +L E ++K ++A L +K+L
Sbjct: 17 NGEAGEFLPEDFRDGEYEAAVTLEKQEDLKTLLAHPVTLGEQQWKSEKQREAELKKKKLE 76
Query: 157 KLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETG------ETPLTLAAQLDDS 210
+ NL+ IQ + +K K P +PE + P L A L++
Sbjct: 77 QRSKLENLEDLEIIIQLKKRKKYRKTKV----PVVKEPEPEIITEPVDVPTFLKAALENK 132
Query: 211 VEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYH 270
+ V++ + + D + TALH+A + ++ L+E GA +++D T + H
Sbjct: 133 LPVVEKFLSDKNNPDVCDEYKRTALHRACLEGHLAIVEKLMEAGAQIEFRDMLESTAI-H 191
Query: 271 TAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNAS 330
A GG+ +LLL++ A + +D+ +H A R GH + EHL+ AD++A++
Sbjct: 192 WASRGGNLDVLKLLLNKGAKISARDKLLSTALHVAVRTGHYECAEHLIACEADLNAKDRE 251
Query: 331 GNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
G+T LH N+ R+L+ G + +KN +TP +
Sbjct: 252 GDTPLHDAVRLNRYKMIRLLIMYGADLNIKNCAGKTPMDL 291
>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
Length = 1053
Score = 83.2 bits (204), Expect = 4e-16
Identities = 68/232 (29%), Positives = 105/232 (45%), Gaps = 12/232 (5%)
Query: 151 DEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDS 210
D K L LH + C + E + +L D N D + +TPL +AA + +
Sbjct: 71 DSKWLTPLHRA--VASCSE-------EAVQVLLKHSADVNARD-KNWQTPLHIAAA-NKA 119
Query: 211 VEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYH 270
V+ +AL ++++ + G TALH AA + + +K LL GA+ + D + H
Sbjct: 120 VKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAI-H 178
Query: 271 TAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNAS 330
A G +LL+ A V CKD+ + +H A G + +++LL G DM+ NA
Sbjct: 179 WAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAY 238
Query: 331 GNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVKEISASGRMCVD 382
GNT LH+ QD L+ G KN TP S G +C++
Sbjct: 239 GNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLE 290
Score = 80.1 bits (196), Expect = 3e-15
Identities = 59/182 (32%), Positives = 90/182 (49%), Gaps = 6/182 (3%)
Query: 175 LVEKITKMLDRGLDPNFHDPET-GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMT 233
++ + +LD G+D N +P G TPL +A V V+ L + GA ++ + + G T
Sbjct: 218 MISVVKYLLDLGVDMN--EPNAYGNTPLHVACYNGQDV-VVNELIDCGAIVNQKNEKGFT 274
Query: 234 ALH-KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVC 292
LH AA + L+ L+ GA + K G TPL+ TA+ G + ++ A +
Sbjct: 275 PLHFAAASTHGALCLELLVGNGADVNMKSKDGKTPLHMTALHGRFSRS-QTIIQSGAVID 333
Query: 293 CKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLF 352
C+D+NG +H A RYGH + L+ GAD + + G LH+ AL C R LL
Sbjct: 334 CEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLS 393
Query: 353 RG 354
G
Sbjct: 394 SG 395
Score = 76.3 bits (186), Expect = 4e-14
Identities = 52/205 (25%), Positives = 89/205 (43%), Gaps = 2/205 (0%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
+E + ++ G + D ++ TPL AA + V+K L + G ++ G T L
Sbjct: 186 IEVVKLLVSHGAEVTCKDKKS-YTPLHAAAS-SGMISVVKYLLDLGVDMNEPNAYGNTPL 243
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
H A V + L++ GA + K+ G TPL+ A C ELL+ A V K
Sbjct: 244 HVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNMKS 303
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGG 355
++G +H +G + ++ GA + ++ +GNT LHI A Y + L+ G
Sbjct: 304 KDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA 363
Query: 356 NKELKNYNSQTPFQVKEISASGRMC 380
+ + + P + +S C
Sbjct: 364 DTAKRGIHGMFPLHLAALSGFSDCC 388
Score = 73.6 bits (179), Expect = 3e-13
Identities = 58/205 (28%), Positives = 98/205 (47%), Gaps = 5/205 (2%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
+++ ++ + D NF D E TPL AA L D+ E+I+ L GA ++ + +T LH
Sbjct: 22 DEVRALIFKKEDVNFQDNEK-RTPLHAAAYLGDA-EIIELLILSGARVNAKDSKWLTPLH 79
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
+A + ++ A++ LL+ A + +D TPL H A C E L+ + V D
Sbjct: 80 RAVASCSEEAVQVLLKHSADVNARDKNWQTPL-HIAAANKAVKCAEALVPLLSNVNVSDR 138
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
G +H A GH + ++ LL GA+++A + A+H A ++L+ G
Sbjct: 139 AGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAE 198
Query: 357 KELKNYNSQTPFQVKEISASGRMCV 381
K+ S TP ++SG + V
Sbjct: 199 VTCKDKKSYTPLHA--AASSGMISV 221
Score = 73.6 bits (179), Expect = 3e-13
Identities = 56/202 (27%), Positives = 91/202 (45%), Gaps = 3/202 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
++ G D N + G+TPL + A L + + GA +D K+G T LH AAR
Sbjct: 292 LVGNGADVNMKSKD-GKTPLHMTA-LHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARY 349
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+++ + TL+ GA + +G+ PL H A + G CC LL + D+ G
Sbjct: 350 GHELLINTLITSGADTAKRGIHGMFPL-HLAALSGFSDCCRKLLSSGFDIDTPDDFGRTC 408
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A G+++ L LL GAD + ++ G + LH A C L+ G + +
Sbjct: 409 LHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLD 468
Query: 362 YNSQTPFQVKEISASGRMCVDH 383
TP S + C+++
Sbjct: 469 ERGCTPLHYAATSDTDGKCLEY 490
Score = 71.2 bits (173), Expect = 1e-12
Identities = 61/214 (28%), Positives = 95/214 (44%), Gaps = 15/214 (7%)
Query: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAAR 240
K+L G D + D + G T L AA ++E + L N GA + + K G + LH AA
Sbjct: 390 KLLSSGFDIDTPD-DFGRTCLHAAAA-GGNLECLNLLLNTGADFNKKDKFGRSPLHYAAA 447
Query: 241 ARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
N L L+ GAS + D G TPL++ A D C E LL A +D+ G++
Sbjct: 448 NCNYQCLFALVGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYN 507
Query: 301 EIHQACRYGHVQHLEHLL----------FYGADM--SAQNASGNTALHICALYNQDSCAR 348
+H + YGH L+ + G DM + N + + LH+ A +
Sbjct: 508 AVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALE 567
Query: 349 VLLFRGGNKELKNYNSQTPFQVKEISASGRMCVD 382
VL+ + +++N + +TP + CVD
Sbjct: 568 VLVQSLLDLDVRNSSGRTPLDLAAFKGHVE-CVD 600
Score = 62.4 bits (150), Expect = 7e-10
Identities = 49/160 (30%), Positives = 77/160 (48%), Gaps = 9/160 (5%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G+TPL L+ L+ + + +L N GA++D + K G TALH+ A ++ + LL+ GA
Sbjct: 653 GQTPLMLSV-LNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAK 711
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELL---LHEHATVCCKDENGWHEIHQACRYGHVQH 313
+DS G TP++ +A G LL A D +G+ +H AC GH
Sbjct: 712 CLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETC 771
Query: 314 LEHLLFYGADMSAQNASGN--TALHICALYNQDSCARVLL 351
+E LL Q GN + LH + + + A +L+
Sbjct: 772 VELLL---EQEVFQKTEGNAFSPLHCAVINDNEGAAEMLI 808
Score = 58.9 bits (141), Expect = 7e-09
Identities = 44/159 (27%), Positives = 75/159 (47%), Gaps = 1/159 (0%)
Query: 198 ETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASP 257
+ P + A + + ++AL ++F+ + T LH AA + ++ L+ GA
Sbjct: 8 DQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARV 67
Query: 258 DYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL 317
+ KDS LTPL H A+ ++LL A V +D+N +H A V+ E L
Sbjct: 68 NAKDSKWLTPL-HRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL 126
Query: 318 LFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGN 356
+ ++++ + +G TALH A ++LL RG N
Sbjct: 127 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGAN 165
Score = 56.2 bits (134), Expect = 5e-08
Identities = 50/175 (28%), Positives = 72/175 (41%), Gaps = 4/175 (2%)
Query: 199 TPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPD 258
+PL LAA + ++ L LD R G T L AA + + L+ GAS
Sbjct: 552 SPLHLAAYHGHH-QALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASIL 610
Query: 259 YKDSYGLTPLYHTAIVGGDPYCCELLL---HEHATVCCKDENGWHEIHQACRYGHVQHLE 315
KD H A G C LL+ V +D NG + + GH +
Sbjct: 611 VKDYILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVY 670
Query: 316 HLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL GA++ A++ G TALH A+ + C LL G L++ +TP +
Sbjct: 671 SLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHL 725
Score = 43.5 bits (101), Expect = 3e-04
Identities = 41/140 (29%), Positives = 58/140 (41%), Gaps = 3/140 (2%)
Query: 231 GMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHAT 290
G T LH AA + L+ LL A + DS G TPL A G L+ A
Sbjct: 823 GRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVEMLVSSASAE 882
Query: 291 VCCKDENGWHEIHQACRYGHVQHLEHLLFYGAD---MSAQNASGNTALHICALYNQDSCA 347
+ +D + +H AC GH +L D ++A NA+ T LH+ A
Sbjct: 883 LTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVAARNGLTMVV 942
Query: 348 RVLLFRGGNKELKNYNSQTP 367
+ LL +G + + N TP
Sbjct: 943 QELLGKGASVLAVDENGYTP 962
Score = 40.4 bits (93), Expect = 0.003
Identities = 26/99 (26%), Positives = 44/99 (44%)
Query: 272 AIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASG 331
AI GDP L+ + V +D +H A G + +E L+ GA ++A+++
Sbjct: 15 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKW 74
Query: 332 NTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
T LH + +VLL + ++ N QTP +
Sbjct: 75 LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHI 113
Score = 38.1 bits (87), Expect = 0.013
Identities = 36/127 (28%), Positives = 56/127 (44%), Gaps = 5/127 (3%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
VE + +L N D TG+TPL +AA+ + V + + A L + TAL
Sbjct: 836 VECLQLLLSHNAQVNSVD-STGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTAL 894
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGL---TPLYHTAIVGGDPYCCELLLHEHATVC 292
H A ++ + +LE + ++ TPL H A G + LL + A+V
Sbjct: 895 HLACSKGHETSALLILEKITDRNLINATNAALQTPL-HVAARNGLTMVVQELLGKGASVL 953
Query: 293 CKDENGW 299
DENG+
Sbjct: 954 AVDENGY 960
>gi|116875852 HECT domain and ankyrin repeat containing, E3
ubiquitin protein ligase 1 [Homo sapiens]
Length = 909
Score = 82.0 bits (201), Expect = 8e-16
Identities = 64/209 (30%), Positives = 100/209 (47%), Gaps = 5/209 (2%)
Query: 172 QHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDG 231
QHR V ++ + + D N+ + L +AA SVE + L GA+ +++ G
Sbjct: 42 QHRSVSEL--LSNSKFDVNYAFGRVKRSLLHIAANCG-SVECLVLLLKKGANPNYQDISG 98
Query: 232 MTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATV 291
T LH AAR + + LLE A + ++ GLT ++ A+ G +L+ H + V
Sbjct: 99 CTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHV-SDV 157
Query: 292 CCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLL 351
+D G +H AC+ GH ++ LL GAD++ N SG T L+ + Q A++LL
Sbjct: 158 DVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILL 217
Query: 352 FRGGNKELKNYNSQTPFQVKEISASGRMC 380
RG K L + N TP + G C
Sbjct: 218 LRGA-KYLPDKNGVTPLDLCVQGGYGETC 245
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 79.3 bits (194), Expect = 5e-15
Identities = 68/244 (27%), Positives = 109/244 (44%), Gaps = 11/244 (4%)
Query: 128 PVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGL 187
P+G G +LE K + Q S K+L + + ++ ++ ++K+ ML L
Sbjct: 590 PLGPGREALE----KALVIQESERRKKL-----RFHPRQLYLSVKQGELQKVILMLLDNL 640
Query: 188 DPNFH-DPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVA 246
DPNF D ++ TPL AAQ SVE+ L GA+++ K T L +A +
Sbjct: 641 DPNFQSDQQSKRTPLHAAAQ-KGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEV 699
Query: 247 LKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQAC 306
+ +++ G K+ G T L+H A +G LL V +D GW I A
Sbjct: 700 ARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAA 759
Query: 307 RYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQT 366
+ H++ + LL GAD++ + N LH + + A VLL + NY+ T
Sbjct: 760 EHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDT 819
Query: 367 PFQV 370
P +
Sbjct: 820 PLHI 823
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 79.3 bits (194), Expect = 5e-15
Identities = 68/244 (27%), Positives = 109/244 (44%), Gaps = 11/244 (4%)
Query: 128 PVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNLKKCMDHIQHRLVEKITKMLDRGL 187
P+G G +LE K + Q S K+L + + ++ ++ ++K+ ML L
Sbjct: 624 PLGPGREALE----KALVIQESERRKKL-----RFHPRQLYLSVKQGELQKVILMLLDNL 674
Query: 188 DPNFH-DPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVA 246
DPNF D ++ TPL AAQ SVE+ L GA+++ K T L +A +
Sbjct: 675 DPNFQSDQQSKRTPLHAAAQ-KGSVEICHVLLQAGANINAVDKQQRTPLMEAVVNNHLEV 733
Query: 247 LKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQAC 306
+ +++ G K+ G T L+H A +G LL V +D GW I A
Sbjct: 734 ARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAA 793
Query: 307 RYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQT 366
+ H++ + LL GAD++ + N LH + + A VLL + NY+ T
Sbjct: 794 EHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDT 853
Query: 367 PFQV 370
P +
Sbjct: 854 PLHI 857
>gi|55742857 ankyrin repeat domain 6 [Homo sapiens]
Length = 722
Score = 79.3 bits (194), Expect = 5e-15
Identities = 58/174 (33%), Positives = 80/174 (45%), Gaps = 2/174 (1%)
Query: 197 GETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGAS 256
G TPL LAA + V++ L G LD + TALH+A N + L+ G +
Sbjct: 42 GRTPLHLAAN-KGHLPVVQILLKAGCDLDVQDDGDQTALHRATVVGNTEIIAALIHEGCA 100
Query: 257 PDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEH 316
D +D G T L H A G +LL+ A V K++ G +H AC+ H Q
Sbjct: 101 LDRQDKDGNTAL-HEASWHGFSQSAKLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRV 159
Query: 317 LLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LL G+ +N +G+T LH+ A YN S R+LL + KN T V
Sbjct: 160 LLLAGSRADLKNNAGDTCLHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHV 213
Score = 77.4 bits (189), Expect = 2e-14
Identities = 58/188 (30%), Positives = 89/188 (47%), Gaps = 3/188 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+L G D + D G+ A + + E+I AL + G LD + KDG TALH+A+
Sbjct: 61 LLKAGCDLDVQDD--GDQTALHRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWH 118
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ K L++ GA+ K+ G T L H A +LL + K+ G
Sbjct: 119 GFSQSAKLLVKAGANVLAKNKAGNTAL-HLACQNSHSQSTRVLLLAGSRADLKNNAGDTC 177
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKN 361
+H A RY H+ + LL + +N +G+TALH+ A N A++LL G + + N
Sbjct: 178 LHVAARYNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVN 237
Query: 362 YNSQTPFQ 369
QTP +
Sbjct: 238 NAGQTPLE 245
Score = 76.6 bits (187), Expect = 3e-14
Identities = 55/168 (32%), Positives = 80/168 (47%), Gaps = 2/168 (1%)
Query: 203 LAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDS 262
L A E + L N GA + K G T LH AA + ++ LL+ G D +D
Sbjct: 15 LVAAYKGQTENVVQLINKGARVAV-TKHGRTPLHLAANKGHLPVVQILLKAGCDLDVQDD 73
Query: 263 YGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGA 322
T L H A V G+ L+HE + +D++G +H+A +G Q + L+ GA
Sbjct: 74 GDQTAL-HRATVVGNTEIIAALIHEGCALDRQDKDGNTALHEASWHGFSQSAKLLVKAGA 132
Query: 323 DMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
++ A+N +GNTALH+ + RVLL G +LKN T V
Sbjct: 133 NVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCLHV 180
Score = 50.8 bits (120), Expect = 2e-06
Identities = 42/136 (30%), Positives = 62/136 (45%), Gaps = 1/136 (0%)
Query: 215 KALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIV 274
K L GA++ + K G TALH A + + + + LL G+ D K++ G T L H A
Sbjct: 125 KLLVKAGANVLAKNKAGNTALHLACQNSHSQSTRVLLLAGSRADLKNNAGDTCL-HVAAR 183
Query: 275 GGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTA 334
LLL +V K++ G +H A H + + LL GAD + N +G T
Sbjct: 184 YNHLSIIRLLLTAFCSVHEKNQAGDTALHVAAALNHKKVAKILLEAGADTTIVNNAGQTP 243
Query: 335 LHICALYNQDSCARVL 350
L +N A +L
Sbjct: 244 LETARYHNNPEVALLL 259
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 77.4 bits (189), Expect = 2e-14
Identities = 52/138 (37%), Positives = 69/138 (50%), Gaps = 2/138 (1%)
Query: 231 GMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHAT 290
G T LH AAR A + LLE GA+P+ D G TPL H A+ C+LLL T
Sbjct: 1634 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPL-HAAVAADAREVCQLLLRSRQT 1692
Query: 291 -VCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARV 349
V + E+G + A R +E L+ AD+ A++ G TALH A N AR
Sbjct: 1693 AVDARTEDGTTPLMLAARLAVEDLVEELIAAQADVGARDKWGKTALHWAAAVNNARAARS 1752
Query: 350 LLFRGGNKELKNYNSQTP 367
LL G +K+ ++ QTP
Sbjct: 1753 LLQAGADKDAQDNREQTP 1770
Score = 62.4 bits (150), Expect = 7e-10
Identities = 57/190 (30%), Positives = 84/190 (44%), Gaps = 3/190 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+LD G P H TGETPL LAA+ + L+ GA+ + + G T LH A A
Sbjct: 1619 LLDGGACPQAHTVGTGETPLHLAARFSRPTAARRLLE-AGANPNQPDRAGRTPLHAAVAA 1677
Query: 242 RNQVALKTLLELGASP-DYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWH 300
+ + LL + D + G TPL A + + EL+ + A V +D+ G
Sbjct: 1678 DAREVCQLLLRSRQTAVDARTEDGTTPLMLAARLAVEDLVEELIAAQ-ADVGARDKWGKT 1736
Query: 301 EIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELK 360
+H A + + LL GAD AQ+ T L + A A++LL G +EL+
Sbjct: 1737 ALHWAAAVNNARAARSLLQAGADKDAQDNREQTPLFLAAREGAVEVAQLLLGLGAARELR 1796
Query: 361 NYNSQTPFQV 370
+ P V
Sbjct: 1797 DQAGLAPADV 1806
Score = 31.6 bits (70), Expect = 1.3
Identities = 25/93 (26%), Positives = 39/93 (41%), Gaps = 3/93 (3%)
Query: 289 ATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNA-SGNTALHICALYNQDSCA 347
+ VCC + Q G + E LL GA A +G T LH+ A +++ + A
Sbjct: 1593 SAVCCGEVQSG--TFQGAWLGCPEPWEPLLDGGACPQAHTVGTGETPLHLAARFSRPTAA 1650
Query: 348 RVLLFRGGNKELKNYNSQTPFQVKEISASGRMC 380
R LL G N + +TP + + +C
Sbjct: 1651 RRLLEAGANPNQPDRAGRTPLHAAVAADAREVC 1683
>gi|116063534 ankyrin repeat domain 27 (VPS9 domain) [Homo sapiens]
Length = 1050
Score = 76.6 bits (187), Expect = 3e-14
Identities = 57/194 (29%), Positives = 88/194 (45%), Gaps = 6/194 (3%)
Query: 181 KMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKD--GMTALHKA 238
K ++R L HD +T + DD +++ N + + ++D G T LH A
Sbjct: 411 KEVERLLSQEDHDKDTVQKMCHPLCFCDDCEKLVSGRLNDPSVVTPFSRDDRGHTPLHVA 470
Query: 239 ARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENG 298
A + L+ GA + D +G TPL H A G LLLH A+ +D NG
Sbjct: 471 AVCGQASLIDLLVSKGAMVNATDYHGATPL-HLACQKGYQSVTLLLLHYKASAEVQDNNG 529
Query: 299 WHEIHQACRYGHVQHLEHLLFYGAD---MSAQNASGNTALHICALYNQDSCARVLLFRGG 355
+H AC YGH ++ L++Y + + N G+T LHI A + LL G
Sbjct: 530 NTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHIAARWGYQGVIETLLQNGA 589
Query: 356 NKELKNYNSQTPFQ 369
+ E++N +TP +
Sbjct: 590 STEIQNRLKETPLK 603
Score = 62.4 bits (150), Expect = 7e-10
Identities = 53/166 (31%), Positives = 78/166 (46%), Gaps = 4/166 (2%)
Query: 177 EKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALH 236
+++ K+ GL N + G +PL +AA L ++I L GA+ R D LH
Sbjct: 725 KRLAKVPASGLGVNVTSQD-GSSPLHVAA-LHGRADLIPLLLKHGANAGARNADQAVPLH 782
Query: 237 KAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE 296
A + + +K LL+ A P+ KD G TPL + A GG LLL A++ +
Sbjct: 783 LACQQGHFQVVKCLLDSNAKPNKKDLSGNTPLIY-ACSGGHHELVALLLQHGASINASNN 841
Query: 297 NGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYN 342
G +H+A HV +E LL +GA + N TA+ CA N
Sbjct: 842 KGNTALHEAVIEKHVFVVELLLLHGASVQVLNKRQRTAVD-CAEQN 886
Score = 58.9 bits (141), Expect = 7e-09
Identities = 36/118 (30%), Positives = 55/118 (46%), Gaps = 4/118 (3%)
Query: 256 SPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLE 315
+P +D G TPL H A V G +LL+ + A V D +G +H AC+ G+
Sbjct: 455 TPFSRDDRGHTPL-HVAAVCGQASLIDLLVSKGAMVNATDYHGATPLHLACQKGYQSVTL 513
Query: 316 HLLFYGADMSAQNASGNTALHICALYNQDSCARVLLF---RGGNKELKNYNSQTPFQV 370
LL Y A Q+ +GNT LH+ Y + C + L++ ++ N TP +
Sbjct: 514 LLLHYKASAEVQDNNGNTPLHLACTYGHEDCVKALVYYDVESCRLDIGNEKGDTPLHI 571
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 75.1 bits (183), Expect = 1e-13
Identities = 53/182 (29%), Positives = 90/182 (49%), Gaps = 2/182 (1%)
Query: 203 LAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKDS 262
L A ++ ++VI+ G D + TALH+A+ + L+ LL+ GA+ D++D
Sbjct: 153 LKAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVDFQDR 212
Query: 263 YGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGA 322
T + H A GG +LL A +D+ +H A R G V+ +EH L G
Sbjct: 213 LDCTAM-HWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRTGQVEIVEHFLSLGL 271
Query: 323 DMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQVKEI-SASGRMCV 381
+++A++ G+TALH N+ ++LL G + KN +TP + ++ A R +
Sbjct: 272 EINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLWQADTRHAL 331
Query: 382 DH 383
+H
Sbjct: 332 EH 333
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 75.1 bits (183), Expect = 1e-13
Identities = 61/200 (30%), Positives = 92/200 (46%), Gaps = 8/200 (4%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
++ + ++ RG D D G TPLTLAA+ +V+ L GA+++ +DG TAL
Sbjct: 558 LDVVNLLVSRGADLEIEDAH-GHTPLTLAAR-QGHTKVVNCLIGCGANINHTDQDGWTAL 615
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
AA + + LL G D D+ T L A G + LL H A V D
Sbjct: 616 RSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQH-GAEVNKAD 674
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICAL-----YNQDSCARVL 350
G + A GH + +EHLL +GA+++ ++ G TAL + AL S +L
Sbjct: 675 NEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLL 734
Query: 351 LFRGGNKELKNYNSQTPFQV 370
+ RG + + + TP V
Sbjct: 735 IDRGAEVDHCDKDGMTPLLV 754
Score = 75.1 bits (183), Expect = 1e-13
Identities = 60/227 (26%), Positives = 96/227 (42%), Gaps = 34/227 (14%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
V+ + +L+ G D + H G TPL AA + + V+ L GA +D +G T L
Sbjct: 761 VDVVDLLLEGGADVD-HTDNNGRTPLLAAASMGHA-SVVNTLLFWGAAVDSIDSEGRTVL 818
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVG-------------------- 275
A+ N ++TLL+ G +++D G TPL+ A G
Sbjct: 819 SIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDN 878
Query: 276 ------------GDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGAD 323
G C ++LL + + + +G + + A GH +E L +GAD
Sbjct: 879 DGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGAD 938
Query: 324 MSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
++ ++A G L+I AL NQ + A L G N E + +T V
Sbjct: 939 VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHV 985
Score = 70.5 bits (171), Expect = 2e-12
Identities = 60/207 (28%), Positives = 91/207 (43%), Gaps = 8/207 (3%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
+ +L G + N D E G T L AA + E+++ L + GA ++ DG TAL A
Sbjct: 660 VLNLLQHGAEVNKADNE-GRTALIAAAYMGHR-EIVEHLLDHGAEVNHEDVDGRTALSVA 717
Query: 239 ARA-----RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCC 293
A + + L++ GA D+ D G+TPL A G +LLL A V
Sbjct: 718 ALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLL-VAAYEGHVDVVDLLLEGGADVDH 776
Query: 294 KDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFR 353
D NG + A GH + LLF+GA + + ++ G T L I + R LL R
Sbjct: 777 TDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDR 836
Query: 354 GGNKELKNYNSQTPFQVKEISASGRMC 380
G ++ ++ TP + +C
Sbjct: 837 GLDENHRDDAGWTPLHMAAFEGHRLIC 863
Score = 66.2 bits (160), Expect = 5e-11
Identities = 61/203 (30%), Positives = 92/203 (45%), Gaps = 8/203 (3%)
Query: 170 HIQHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDS----VEVIKALKNGGAHLD 225
++ HR E + +LD G + N H+ G T L++AA + V+ L + GA +D
Sbjct: 686 YMGHR--EIVEHLLDHGAEVN-HEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVD 742
Query: 226 FRAKDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLL 285
KDGMT L AA + + LLE GA D+ D+ G TPL A +G LL
Sbjct: 743 HCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMG-HASVVNTLL 801
Query: 286 HEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDS 345
A V D G + A G+V+ + LL G D + ++ +G T LH+ A
Sbjct: 802 FWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRL 861
Query: 346 CARVLLFRGGNKELKNYNSQTPF 368
L+ +G + + + PF
Sbjct: 862 ICEALIEQGARTNEIDNDGRIPF 884
Score = 63.5 bits (153), Expect = 3e-10
Identities = 53/176 (30%), Positives = 81/176 (46%), Gaps = 3/176 (1%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTAL 235
VE + +LDRGLD N D + G TPL +AA + + +AL GA + DG
Sbjct: 827 VEVVRTLLDRGLDENHRD-DAGWTPLHMAA-FEGHRLICEALIEQGARTNEIDNDGRIPF 884
Query: 236 HKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKD 295
A++ + ++ LLE ++ D + G L A + G ELL A V CKD
Sbjct: 885 ILASQEGHYDCVQILLENKSNIDQRGYDGRNAL-RVAALEGHRDIVELLFSHGADVNCKD 943
Query: 296 ENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLL 351
+G ++ + E+ L GA++ A +A G TALH+ +VL+
Sbjct: 944 ADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLI 999
Score = 52.8 bits (125), Expect = 5e-07
Identities = 44/165 (26%), Positives = 78/165 (47%), Gaps = 3/165 (1%)
Query: 202 TLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASPDYKD 261
+L+ + EV++ L GAH++ ++D T+ + +++TLL+ GAS + D
Sbjct: 485 SLSTLIPKEQEVLQLLVKAGAHVN--SEDDRTSCIVRQALEREDSIRTLLDNGASVNQCD 542
Query: 262 SYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYG 321
S G T L + A G LL+ A + +D +G + A R GH + + L+ G
Sbjct: 543 SNGRTLLANAAY-SGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCG 601
Query: 322 ADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQT 366
A+++ + G TAL A LL+ G + + +S+T
Sbjct: 602 ANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRT 646
Score = 52.8 bits (125), Expect = 5e-07
Identities = 51/196 (26%), Positives = 85/196 (43%), Gaps = 10/196 (5%)
Query: 175 LVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTA 234
L+E + + RG D G L +AA L+ ++++ L + GA ++ + DG
Sbjct: 899 LLENKSNIDQRGYD--------GRNALRVAA-LEGHRDIVELLFSHGADVNCKDADGRPT 949
Query: 235 LHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCK 294
L+ A + LE GA+ + D+ G T L H + G ++L+ HA V
Sbjct: 950 LYILALENQLTMAEYFLENGANVEASDAEGRTAL-HVSCWQGHMEMVQVLIAYHADVNAA 1008
Query: 295 DENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRG 354
D + A GHV+ ++ L+ +GA + G TAL I A +VLL G
Sbjct: 1009 DNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHG 1068
Query: 355 GNKELKNYNSQTPFQV 370
+ + +T +V
Sbjct: 1069 ADPNHADQFGRTAMRV 1084
Score = 47.8 bits (112), Expect = 2e-05
Identities = 51/181 (28%), Positives = 75/181 (41%), Gaps = 7/181 (3%)
Query: 192 HDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLL 251
H + G T L AA EV+ AL G +D D TAL AA ++ + LL
Sbjct: 606 HTDQDGWTALRSAAW-GGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLL 664
Query: 252 ELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQA-----C 306
+ GA + D+ G T L A + G E LL A V +D +G + A
Sbjct: 665 QHGAEVNKADNEGRTALIAAAYM-GHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPA 723
Query: 307 RYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQT 366
GH + L+ GA++ + G T L + A +LL G + + + N +T
Sbjct: 724 SKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRT 783
Query: 367 P 367
P
Sbjct: 784 P 784
Score = 43.1 bits (100), Expect = 4e-04
Identities = 39/169 (23%), Positives = 73/169 (43%), Gaps = 3/169 (1%)
Query: 182 MLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARA 241
+ G D N D + T LA L++ + + + GA+++ +G TALH +
Sbjct: 932 LFSHGADVNCKDADGRPTLYILA--LENQLTMAEYFLENGANVEASDAEGRTALHVSCWQ 989
Query: 242 RNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHE 301
+ ++ L+ A + D+ + L +A G +LL+ A V G
Sbjct: 990 GHMEMVQVLIAYHADVNAADNEKRSAL-QSAAWQGHVKVVQLLIEHGAVVDHTCNQGATA 1048
Query: 302 IHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVL 350
+ A + GH+ ++ LL +GAD + + G TA+ + A ++L
Sbjct: 1049 LCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLL 1097
Score = 32.0 bits (71), Expect = 0.96
Identities = 21/65 (32%), Positives = 34/65 (52%), Gaps = 1/65 (1%)
Query: 192 HDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLL 251
H G T L +AAQ + ++V++ L GA + + G TA+ AA+ + +K L
Sbjct: 1040 HTCNQGATALCIAAQ-EGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLE 1098
Query: 252 ELGAS 256
+ GAS
Sbjct: 1099 KYGAS 1103
>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
Length = 305
Score = 74.3 bits (181), Expect = 2e-13
Identities = 69/240 (28%), Positives = 112/240 (46%), Gaps = 19/240 (7%)
Query: 146 KQASLDEKQLAKLHTKTNLKKCMDHIQ--HRLVEKITKMLDRGLDPNFHDP------ETG 197
++ L+E++ KL + + +D++ LV++ K L + P +P +
Sbjct: 47 EKLKLEEEKKKKLERFNSTRFNLDNLADLENLVQRRKKRLRHRVPPRKPEPLVKPQSQAQ 106
Query: 198 ETPLTLAAQLDDSVE-----VIKALKNGGAHLDFRAKDGM--TALHKAARARNQVALKTL 250
P+ L L + E + K L +GG D A D + TALH A + + L
Sbjct: 107 VEPVGLEMFLKAAAENQEYLIDKYLTDGG---DPNAHDKLHRTALHWACLKGHSQLVNKL 163
Query: 251 LELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGH 310
L GA+ D +D TP++ A GG + LL++ A V +D+ G +H A R H
Sbjct: 164 LVAGATVDARDLLDRTPVFW-ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRH 222
Query: 311 VQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTPFQV 370
LEHL+ GA ++AQ+ G+TALH + ++LL G ++N S TP Q+
Sbjct: 223 PDCLEHLIECGAHLNAQDKEGDTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQL 282
>gi|30348954 mindbomb homolog 1 [Homo sapiens]
Length = 1006
Score = 73.6 bits (179), Expect = 3e-13
Identities = 63/199 (31%), Positives = 95/199 (47%), Gaps = 7/199 (3%)
Query: 172 QHRLVEKITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDG 231
Q+ V+ + +L + +D D + G+ + AA D+ VI+ L G A L+ R K
Sbjct: 473 QNGHVDILKLLLKQNVDVEAEDKD-GDRAVHHAAFGDEGA-VIEVLHRGSADLNARNKRR 530
Query: 232 MTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATV 291
T LH A + +KTLL+ G P +DS G TPL H AI +LL A V
Sbjct: 531 QTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPL-HDAISKKRDDILAVLLEAGADV 589
Query: 292 CCKDENGWHEIHQACRYGHVQHLEHLLFYGAD---MSAQNASGNTALHICALYNQDSCAR 348
+ NG++ +H A G+ + LL + + G TALH+ AL N A
Sbjct: 590 TITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAE 649
Query: 349 VLLFRG-GNKELKNYNSQT 366
+L+ +G N +++N N QT
Sbjct: 650 LLVHQGNANLDIQNVNQQT 668
Score = 70.1 bits (170), Expect = 3e-12
Identities = 50/174 (28%), Positives = 82/174 (47%), Gaps = 6/174 (3%)
Query: 198 ETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASP 257
+TPL +A ++V+K L + G H + +G T LH A + L LLE GA
Sbjct: 531 QTPLHIAVN-KGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADV 589
Query: 258 DYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDE---NGWHEIHQACRYGHVQHL 314
++ G L+H A+ G+P +LL + DE +G+ +H A HV+
Sbjct: 590 TITNNNGFNALHHAAL-RGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVA 648
Query: 315 EHLLFYG-ADMSAQNASGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
E L+ G A++ QN + TALH+ R+L+ G ++++ + TP
Sbjct: 649 ELLVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTP 702
Score = 62.0 bits (149), Expect = 9e-10
Identities = 51/167 (30%), Positives = 79/167 (47%), Gaps = 11/167 (6%)
Query: 176 VEKITKMLDRGLDPNFHDPETGETPL--TLAAQLDDSVEVIKALKNGGAHLDFRAKDGMT 233
++ + +LD G P+ D E G+TPL ++ + DD ++ L GA + +G
Sbjct: 543 LQVVKTLLDFGCHPSLQDSE-GDTPLHDAISKKRDD---ILAVLLEAGADVTITNNNGFN 598
Query: 234 ALHKAARARNQVALKTLLELGASP---DYKDSYGLTPLYHTAIVGGDPYCCELLLHE-HA 289
ALH AA N A++ LL P D K G T L H A + ELL+H+ +A
Sbjct: 599 ALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTAL-HLAALNNHVEVAELLVHQGNA 657
Query: 290 TVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALH 336
+ ++ N +H A H Q + L+ GA + Q+ G+T LH
Sbjct: 658 NLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLH 704
Score = 35.8 bits (81), Expect = 0.067
Identities = 35/138 (25%), Positives = 53/138 (38%), Gaps = 6/138 (4%)
Query: 233 TALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVC 292
+A+ A+ R LK L E S D + A GD E LL
Sbjct: 405 SAISNASGERLSQLLKKLFETQESGDLNEELV------KAAANGDVAKVEDLLKRPDVDV 458
Query: 293 CKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLF 352
G + A + GHV L+ LL D+ A++ G+ A+H A ++ + VL
Sbjct: 459 NGQCAGHTAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHR 518
Query: 353 RGGNKELKNYNSQTPFQV 370
+ +N QTP +
Sbjct: 519 GSADLNARNKRRQTPLHI 536
Score = 34.7 bits (78), Expect = 0.15
Identities = 36/141 (25%), Positives = 56/141 (39%), Gaps = 27/141 (19%)
Query: 198 ETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKAARARNQVALKTLLELGASP 257
+T L LA + + ++++ L GA LD + KDG T LH+A R L+ L ++
Sbjct: 667 QTALHLAVERQHT-QIVRLLVRAGAKLDIQDKDGDTPLHEALRHHTLSQLRQLQDM--QD 723
Query: 258 DYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHL 317
K P +T I+G E A++ C L
Sbjct: 724 VGKVDAAWEPSKNTLIMGLGTQGAE--KKSAASIAC----------------------FL 759
Query: 318 LFYGADMSAQNASGNTALHIC 338
GAD+S +N G + L +C
Sbjct: 760 AANGADLSIRNKKGQSPLDLC 780
Score = 34.3 bits (77), Expect = 0.19
Identities = 24/86 (27%), Positives = 39/86 (45%)
Query: 282 ELLLHEHATVCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALY 341
+LLL ++ V +D++G +H A +E L AD++A+N T LHI
Sbjct: 481 KLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNK 540
Query: 342 NQDSCARVLLFRGGNKELKNYNSQTP 367
+ LL G + L++ TP
Sbjct: 541 GHLQVVKTLLDFGCHPSLQDSEGDTP 566
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 73.2 bits (178), Expect = 4e-13
Identities = 78/278 (28%), Positives = 125/278 (44%), Gaps = 23/278 (8%)
Query: 105 QPASNGRDGKFLDEERLLREYPQPVGEGVPSLEFRYKKRVYKQASLDEKQLAKLHTKTNL 164
+P N DG +D+ + E+ E + + +FR+++ V LD++ + T+ +L
Sbjct: 1795 KPLKNASDGALMDDNQ--NEWGD---EDLETKKFRFEEPVVLP-DLDDQTDHRQWTQQHL 1848
Query: 165 KKCMDHIQHRLVEKITKMLDRG-LDPNFHDPETGETPLTLAA------------QLDDSV 211
+ +D +D N P+ G TPL +A+ + +D+
Sbjct: 1849 DAADLRMSAMAPTPPQGEVDADCMDVNVRGPD-GFTPLMIASCSGGGLETGNSEEEEDAP 1907
Query: 212 EVIKALKNGGAHLDFRA-KDGMTALHKAARARNQVALKTLLELGASPDYKDSYGLTPLYH 270
VI GA L + + G TALH AAR A K LLE A + +D+ G TPL H
Sbjct: 1908 AVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPL-H 1966
Query: 271 TAIVGGDPYCCELLLHEHAT-VCCKDENGWHEIHQACRYGHVQHLEHLLFYGADMSAQNA 329
A+ ++L+ AT + + +G + A R LE L+ AD++A +
Sbjct: 1967 AAVSADAQGVFQILIRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDD 2026
Query: 330 SGNTALHICALYNQDSCARVLLFRGGNKELKNYNSQTP 367
G +ALH A N A VLL G NK+++N +TP
Sbjct: 2027 LGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNREETP 2064
Score = 57.4 bits (137), Expect = 2e-08
Identities = 54/195 (27%), Positives = 84/195 (43%), Gaps = 3/195 (1%)
Query: 179 ITKMLDRGLDPNFHDPETGETPLTLAAQLDDSVEVIKALKNGGAHLDFRAKDGMTALHKA 238
I+ + +G + TGET L LAA+ S + K L A + + G T LH A
Sbjct: 1910 ISDFIYQGASLHNQTDRTGETALHLAARYSRS-DAAKRLLEASADANIQDNMGRTPLHAA 1968
Query: 239 ARARNQVALKTLLELGASP-DYKDSYGLTPLYHTAIVGGDPYCCELLLHEHATVCCKDEN 297
A Q + L+ A+ D + G TPL A + + E L++ HA V D+
Sbjct: 1969 VSADAQGVFQILIRNRATDLDARMHDGTTPLILAARLAVEGML-EDLINSHADVNAVDDL 2027
Query: 298 GWHEIHQACRYGHVQHLEHLLFYGADMSAQNASGNTALHICALYNQDSCARVLLFRGGNK 357
G +H A +V LL GA+ QN T L + A A+VLL N+
Sbjct: 2028 GKSALHWAAAVNNVDAAVVLLKNGANKDMQNNREETPLFLAAREGSYETAKVLLDHFANR 2087
Query: 358 ELKNYNSQTPFQVKE 372
++ ++ + P + +
Sbjct: 2088 DITDHMDRLPRDIAQ 2102
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,514,256
Number of Sequences: 37866
Number of extensions: 716219
Number of successful extensions: 4580
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 337
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 1641
Number of HSP's gapped (non-prelim): 1597
length of query: 385
length of database: 18,247,518
effective HSP length: 104
effective length of query: 281
effective length of database: 14,309,454
effective search space: 4020956574
effective search space used: 4020956574
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.