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Search of human proteins with 167555104
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|167555104 interferon regulatory factor 4 [Homo sapiens]
(451 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|167555104 interferon regulatory factor 4 [Homo sapiens] 963 0.0
gi|4504567 interferon regulatory factor 8 [Homo sapiens] 302 4e-82
gi|5453700 interferon regulatory factor 6 [Homo sapiens] 224 2e-58
gi|148833515 interferon regulatory factor 5 isoform c [Homo sapi... 209 5e-54
gi|148833492 interferon regulatory factor 5 isoform c [Homo sapi... 209 5e-54
gi|148833488 interferon regulatory factor 5 isoform c [Homo sapi... 209 5e-54
gi|148833496 interferon regulatory factor 5 isoform b [Homo sapi... 207 1e-53
gi|14249182 interferon regulatory factor 5 isoform b [Homo sapiens] 207 1e-53
gi|25282407 interferon-stimulated transcription factor 3, gamma ... 207 1e-53
gi|4504727 interferon regulatory factor 5 isoform a [Homo sapiens] 205 6e-53
gi|148833494 interferon regulatory factor 5 isoform d [Homo sapi... 204 1e-52
gi|4504725 interferon regulatory factor 3 [Homo sapiens] 138 1e-32
gi|98985819 interferon regulatory factor 7 isoform d [Homo sapiens] 121 1e-27
gi|4758610 interferon regulatory factor 7 isoform a [Homo sapiens] 121 1e-27
gi|153082752 interferon regulatory factor 2 [Homo sapiens] 121 1e-27
gi|4809284 interferon regulatory factor 7 isoform b [Homo sapiens] 121 1e-27
gi|4504721 interferon regulatory factor 1 [Homo sapiens] 115 6e-26
gi|239757474 PREDICTED: similar to hCG1785205 [Homo sapiens] 63 6e-10
gi|239751984 PREDICTED: similar to hCG1785205 [Homo sapiens] 63 6e-10
gi|239746471 PREDICTED: hypothetical protein XP_002343764 [Homo ... 63 6e-10
gi|51173727 Sma- and Mad-related protein 1 [Homo sapiens] 45 2e-04
gi|5174509 Sma- and Mad-related protein 1 [Homo sapiens] 45 2e-04
gi|118421085 leucine-rich repeat kinase 1 [Homo sapiens] 33 0.40
gi|239048862 checkpoint with forkhead and ring finger domains is... 33 0.69
gi|187828357 SMAD family member 9 isoform a [Homo sapiens] 33 0.69
gi|47778931 SMAD, mothers against DPP homolog 5 [Homo sapiens] 32 0.90
gi|47778929 SMAD, mothers against DPP homolog 5 [Homo sapiens] 32 0.90
gi|47778925 SMAD, mothers against DPP homolog 5 [Homo sapiens] 32 0.90
gi|239047795 pleckstrin homology domain containing, family A mem... 32 1.2
gi|239750586 PREDICTED: hypothetical protein XP_002347439 [Homo ... 32 1.2
>gi|167555104 interferon regulatory factor 4 [Homo sapiens]
Length = 451
Score = 963 bits (2489), Expect = 0.0
Identities = 451/451 (100%), Positives = 451/451 (100%)
Query: 1 MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQ 60
MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQ
Sbjct: 1 MNLEGGGRGGEFGMSAVSCGNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQ 60
Query: 61 DYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISD 120
DYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISD
Sbjct: 61 DYNREEDAALFKAWALFKGKFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISD 120
Query: 121 PYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRD 180
PYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRD
Sbjct: 121 PYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRD 180
Query: 181 YVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIR 240
YVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIR
Sbjct: 181 YVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIR 240
Query: 241 SAEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQ 300
SAEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQ
Sbjct: 241 SAEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQ 300
Query: 301 RKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFD 360
RKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFD
Sbjct: 301 RKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFD 360
Query: 361 TQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQN 420
TQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQN
Sbjct: 361 TQQFLSELQAFAHHGRSLPRFQVTLCFGEEFPDPQRQRKLITAHVEPLLARQLYYFAQQN 420
Query: 421 SGHFLRGYDLPEHISNPEDYHRSIRHSSIQE 451
SGHFLRGYDLPEHISNPEDYHRSIRHSSIQE
Sbjct: 421 SGHFLRGYDLPEHISNPEDYHRSIRHSSIQE 451
>gi|4504567 interferon regulatory factor 8 [Homo sapiens]
Length = 426
Score = 302 bits (774), Expect = 4e-82
Identities = 181/415 (43%), Positives = 233/415 (56%), Gaps = 46/415 (11%)
Query: 20 GNGKLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKG 79
G +LRQWLI+QIDS YPGL+WENEEKS+FRIPWKHAGKQDYN+E DA++FKAWA+FKG
Sbjct: 6 GGRRLRQWLIEQIDSSMYPGLIWENEEKSMFRIPWKHAGKQDYNQEVDASIFKAWAVFKG 65
Query: 80 KFREGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQL 139
KF+EG DK +P TWKTRLRCALNKS DFEE+ +RSQLDIS+PYKVYRIVPE +K +
Sbjct: 66 KFKEG-DKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKCKLGV 124
Query: 140 TLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFG 199
++ ++ + P + + P P
Sbjct: 125 ATAGCVNEVTE--------MECGRSEIDELIKEPSVDDYMGMIKRSPSPP---------- 166
Query: 200 PRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYR 259
AC + Q+ ++A P + GVP + +A + ++ I YY
Sbjct: 167 --------EACRS--QLLPDWWAQQP----STGVPLVTGYTTYDAHHSAFSQMVISFYYG 212
Query: 260 EILVKELTTSSPEGCRISHGH-------TYDASNLDQVLFPYPED----NGQRKNIEKLL 308
LV + TT+ PEGCR+S Y L+ V FP P D QR+ KL
Sbjct: 213 GKLVGQATTTCPEGCRLSLSQPGLPGTKLYGPEGLELVRFP-PADAIPSERQRQVTRKLF 271
Query: 309 SHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFDTQQFLSEL 368
HLERGV+L + G++ KRLCQ R++ G +C RPNKLERD+ ++FDT QF EL
Sbjct: 272 GHLERGVLLHSSRQGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTSQFFREL 331
Query: 369 QAFAHHGRSLPRFQVTLCFGEEFPDPQRQR-KLITAHVEPLLARQLYYFAQQNSG 422
Q F + LP +V LCFGEEFPD R KLI +E L RQL A ++ G
Sbjct: 332 QQFYNSQGRLPDGRVVLCFGEEFPDMAPLRSKLILVQIEQLYVRQLAEEAGKSCG 386
>gi|5453700 interferon regulatory factor 6 [Homo sapiens]
Length = 467
Score = 224 bits (570), Expect = 2e-58
Identities = 146/433 (33%), Positives = 221/433 (51%), Gaps = 52/433 (12%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
+L+ WL+ Q+DSG YPGL+W + + F+IPWKHA + +EE+ +FKAWA+ GK++
Sbjct: 9 RLKPWLVAQVDSGLYPGLIWLHRDSKRFQIPWKHATRHSPQQEEENTIFKAWAVETGKYQ 68
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLE 142
EG+D PDP WK +LRCALNKS +F + + ++ +P K+Y++ +
Sbjct: 69 EGVDDPDPAKWKAQLRCALNKSREFNLMYDGTKEVPMNPVKIYQV-----------CDIP 117
Query: 143 DPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTF---- 198
PQ S+ +P + S P + N +D + DQ +P Q F
Sbjct: 118 QPQGSIINPGST----GSAPWDEKDN----DVDEEDEEDELDQSQHHVPIQDTFPFLNIN 169
Query: 199 -GPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIRSAE----ALAFSDCRLH 253
P G C + P E + P P +P S E +L +D L
Sbjct: 170 GSPMAPASVGNCSVGNCSPEAVWPKTEPLEMEVPQAPIQPFYSSPELWISSLPMTD--LD 227
Query: 254 ICLYYR-EILVKELTTSSPEGCRISHG---------HTYDASNLDQVLFPYPE---DNGQ 300
I YR + + +T S+P+GCR+ +G + +L+QV FP PE + Q
Sbjct: 228 IKFQYRGKEYGQTMTVSNPQGCRLFYGDLGPMPDQEELFGPVSLEQVKFPGPEHITNEKQ 287
Query: 301 RKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFD 360
+ KLL ++RG++L ++ +YA RLCQ ++YW GP A PN +ER + KLF
Sbjct: 288 KLFTSKLLDVMDRGLILEVSGHAIYAIRLCQCKVYWSGPCAPSLVAPNLIERQKKVKLFC 347
Query: 361 TQQFLSELQAFAHHGRSL---PRFQVTLCFGEEFPDPQ-RQRKLITAHVEPLLARQLYYF 416
+ FLS+L AH + P F++ LCFGEE+PD + +RKLI V P++AR +Y
Sbjct: 348 LETFLSDL--IAHQKGQIEKQPPFEIYLCFGEEWPDGKPLERKLILVQVIPVVARMIY-- 403
Query: 417 AQQNSGHFLRGYD 429
+ SG F R +D
Sbjct: 404 -EMFSGDFTRSFD 415
>gi|148833515 interferon regulatory factor 5 isoform c [Homo
sapiens]
Length = 488
Score = 209 bits (531), Expect = 5e-54
Identities = 149/445 (33%), Positives = 214/445 (48%), Gaps = 50/445 (11%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
+L+ WL+ Q++S +YPGL W N EK +F IPW+HA + +++ D +FKAWA GK+
Sbjct: 16 RLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYT 75
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIV-----------PEG 131
EG+D+ DP WK LRCALNKS DF + + + PYK+Y + PE
Sbjct: 76 EGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPED 135
Query: 132 AKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIP 191
GA + E+ ++ P T P + PP+ V P P+
Sbjct: 136 YSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLQPPV-------VLGPPAPDPS 188
Query: 192 YQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPP--ESQAPGVPTEPSIRSAEALAFSD 249
P P G + G A PP E P + P + L +D
Sbjct: 189 PLAPPPGNPAGFR----ELLSEVLEPGPLPASLPPAGEQLLPDLLISPHM-----LPLTD 239
Query: 250 CRLHICLYYREILVKELTTSSPEGCRISHG---------HTYDASNLDQVLFPYPED--- 297
L I YR + LT S+P GCR+ + + +L+QV FP PED
Sbjct: 240 --LEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPS 297
Query: 298 NGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDR-PNKLERDQTC 356
+ QR +LL L+RG++L + LYA RLCQ +++W GP A +D PN ++R+
Sbjct: 298 DKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKT 357
Query: 357 KLFDTQQFLSELQAFAH-HGRSLPRFQVTLCFGEEFPDPQ-RQRKLITAHVEPLLARQLY 414
KLF + FL+EL F + P F++ CFGEE+PD + R++KLIT V P+ AR L
Sbjct: 358 KLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLL- 416
Query: 415 YFAQQNSGHFLRGYD-LPEHISNPE 438
+ SG D + ISNP+
Sbjct: 417 --LEMFSGELSWSADSIRLQISNPD 439
>gi|148833492 interferon regulatory factor 5 isoform c [Homo
sapiens]
Length = 488
Score = 209 bits (531), Expect = 5e-54
Identities = 149/445 (33%), Positives = 214/445 (48%), Gaps = 50/445 (11%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
+L+ WL+ Q++S +YPGL W N EK +F IPW+HA + +++ D +FKAWA GK+
Sbjct: 16 RLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYT 75
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIV-----------PEG 131
EG+D+ DP WK LRCALNKS DF + + + PYK+Y + PE
Sbjct: 76 EGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPED 135
Query: 132 AKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIP 191
GA + E+ ++ P T P + PP+ V P P+
Sbjct: 136 YSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLQPPV-------VLGPPAPDPS 188
Query: 192 YQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPP--ESQAPGVPTEPSIRSAEALAFSD 249
P P G + G A PP E P + P + L +D
Sbjct: 189 PLAPPPGNPAGFR----ELLSEVLEPGPLPASLPPAGEQLLPDLLISPHM-----LPLTD 239
Query: 250 CRLHICLYYREILVKELTTSSPEGCRISHG---------HTYDASNLDQVLFPYPED--- 297
L I YR + LT S+P GCR+ + + +L+QV FP PED
Sbjct: 240 --LEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPS 297
Query: 298 NGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDR-PNKLERDQTC 356
+ QR +LL L+RG++L + LYA RLCQ +++W GP A +D PN ++R+
Sbjct: 298 DKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKT 357
Query: 357 KLFDTQQFLSELQAFAH-HGRSLPRFQVTLCFGEEFPDPQ-RQRKLITAHVEPLLARQLY 414
KLF + FL+EL F + P F++ CFGEE+PD + R++KLIT V P+ AR L
Sbjct: 358 KLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLL- 416
Query: 415 YFAQQNSGHFLRGYD-LPEHISNPE 438
+ SG D + ISNP+
Sbjct: 417 --LEMFSGELSWSADSIRLQISNPD 439
>gi|148833488 interferon regulatory factor 5 isoform c [Homo
sapiens]
Length = 488
Score = 209 bits (531), Expect = 5e-54
Identities = 149/445 (33%), Positives = 214/445 (48%), Gaps = 50/445 (11%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
+L+ WL+ Q++S +YPGL W N EK +F IPW+HA + +++ D +FKAWA GK+
Sbjct: 16 RLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYT 75
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIV-----------PEG 131
EG+D+ DP WK LRCALNKS DF + + + PYK+Y + PE
Sbjct: 76 EGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPED 135
Query: 132 AKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIP 191
GA + E+ ++ P T P + PP+ V P P+
Sbjct: 136 YSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLQPPV-------VLGPPAPDPS 188
Query: 192 YQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPP--ESQAPGVPTEPSIRSAEALAFSD 249
P P G + G A PP E P + P + L +D
Sbjct: 189 PLAPPPGNPAGFR----ELLSEVLEPGPLPASLPPAGEQLLPDLLISPHM-----LPLTD 239
Query: 250 CRLHICLYYREILVKELTTSSPEGCRISHG---------HTYDASNLDQVLFPYPED--- 297
L I YR + LT S+P GCR+ + + +L+QV FP PED
Sbjct: 240 --LEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPS 297
Query: 298 NGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDR-PNKLERDQTC 356
+ QR +LL L+RG++L + LYA RLCQ +++W GP A +D PN ++R+
Sbjct: 298 DKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKT 357
Query: 357 KLFDTQQFLSELQAFAH-HGRSLPRFQVTLCFGEEFPDPQ-RQRKLITAHVEPLLARQLY 414
KLF + FL+EL F + P F++ CFGEE+PD + R++KLIT V P+ AR L
Sbjct: 358 KLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLL- 416
Query: 415 YFAQQNSGHFLRGYD-LPEHISNPE 438
+ SG D + ISNP+
Sbjct: 417 --LEMFSGELSWSADSIRLQISNPD 439
>gi|148833496 interferon regulatory factor 5 isoform b [Homo
sapiens]
Length = 498
Score = 207 bits (528), Expect = 1e-53
Identities = 149/445 (33%), Positives = 215/445 (48%), Gaps = 40/445 (8%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
+L+ WL+ Q++S +YPGL W N EK +F IPW+HA + +++ D +FKAWA GK+
Sbjct: 16 RLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYT 75
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIV-----------PEG 131
EG+D+ DP WK LRCALNKS DF + + + PYK+Y + PE
Sbjct: 76 EGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPED 135
Query: 132 AKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIP 191
GA + E+ ++ P T P + PP + P P P
Sbjct: 136 YSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAP 195
Query: 192 YQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPP--ESQAPGVPTEPSIRSAEALAFSD 249
P+ P G+ + G A PP E P + P + L +D
Sbjct: 196 DPSPLA-PPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDLLISPHM-----LPLTD 249
Query: 250 CRLHICLYYREILVKELTTSSPEGCRISHG---------HTYDASNLDQVLFPYPED--- 297
L I YR + LT S+P GCR+ + + +L+QV FP PED
Sbjct: 250 --LEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPS 307
Query: 298 NGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDR-PNKLERDQTC 356
+ QR +LL L+RG++L + LYA RLCQ +++W GP A +D PN ++R+
Sbjct: 308 DKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKT 367
Query: 357 KLFDTQQFLSELQAFAH-HGRSLPRFQVTLCFGEEFPDPQ-RQRKLITAHVEPLLARQLY 414
KLF + FL+EL F + P F++ CFGEE+PD + R++KLIT V P+ AR L
Sbjct: 368 KLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLL- 426
Query: 415 YFAQQNSGHFLRGYD-LPEHISNPE 438
+ SG D + ISNP+
Sbjct: 427 --LEMFSGELSWSADSIRLQISNPD 449
>gi|14249182 interferon regulatory factor 5 isoform b [Homo sapiens]
Length = 498
Score = 207 bits (528), Expect = 1e-53
Identities = 149/445 (33%), Positives = 215/445 (48%), Gaps = 40/445 (8%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
+L+ WL+ Q++S +YPGL W N EK +F IPW+HA + +++ D +FKAWA GK+
Sbjct: 16 RLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYT 75
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIV-----------PEG 131
EG+D+ DP WK LRCALNKS DF + + + PYK+Y + PE
Sbjct: 76 EGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPED 135
Query: 132 AKKGAKQLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIP 191
GA + E+ ++ P T P + PP + P P P
Sbjct: 136 YSFGAGEEEEEEEELQRMLPSLSLTEDVKWPPTLQPPTLRPPTLQPPTLQPPVVLGPPAP 195
Query: 192 YQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPP--ESQAPGVPTEPSIRSAEALAFSD 249
P+ P G+ + G A PP E P + P + L +D
Sbjct: 196 DPSPLA-PPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDLLISPHM-----LPLTD 249
Query: 250 CRLHICLYYREILVKELTTSSPEGCRISHG---------HTYDASNLDQVLFPYPED--- 297
L I YR + LT S+P GCR+ + + +L+QV FP PED
Sbjct: 250 --LEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGPISLEQVRFPSPEDIPS 307
Query: 298 NGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLALCNDR-PNKLERDQTC 356
+ QR +LL L+RG++L + LYA RLCQ +++W GP A +D PN ++R+
Sbjct: 308 DKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCASAHDSCPNPIQREVKT 367
Query: 357 KLFDTQQFLSELQAFAH-HGRSLPRFQVTLCFGEEFPDPQ-RQRKLITAHVEPLLARQLY 414
KLF + FL+EL F + P F++ CFGEE+PD + R++KLIT V P+ AR L
Sbjct: 368 KLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREKKLITVQVVPVAARLL- 426
Query: 415 YFAQQNSGHFLRGYD-LPEHISNPE 438
+ SG D + ISNP+
Sbjct: 427 --LEMFSGELSWSADSIRLQISNPD 449
>gi|25282407 interferon-stimulated transcription factor 3, gamma
48kDa [Homo sapiens]
Length = 393
Score = 207 bits (528), Expect = 1e-53
Identities = 136/395 (34%), Positives = 208/395 (52%), Gaps = 31/395 (7%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
KLR W+++Q++SG++PG+ W++ K++FRIPWKHAGKQD+ ++DAA FKAWA+FKGK++
Sbjct: 11 KLRNWVVEQVESGQFPGVCWDDTAKTMFRIPWKHAGKQDFREDQDAAFFKAWAIFKGKYK 70
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLE 142
EG D P WKTRLRCALNKS++F+E+ ER ++D+++PYKVY+++P G G
Sbjct: 71 EG-DTGGPAVWKTRLRCALNKSSEFKEVPERGRMDVAEPYKVYQLLPPGIVSG------- 122
Query: 143 DPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRG 202
P T +P+++ H+ + + D + + Q + G
Sbjct: 123 -------QPGTQ-----KVPSKRQHSSVSSE-RKEEEDAMQNCTLSPSVLQDSLNNEEEG 169
Query: 203 HHWQGPACENGCQVTGTFYACAPPE-SQAPGVPTEPSIRSAEAL--AFSDCRLHICLYYR 259
G A + + + + P E + P + RS E L D L + Y
Sbjct: 170 A--SGGAVHSDIGSSSSSSSPEPQEVTDTTEAPFQGDQRSLEFLLPPEPDYSLLLTFIYN 227
Query: 260 EILVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWM 319
+V E S + CR+ + S+++QVLFP P G + ++LLS LERG+++
Sbjct: 228 GRVVGEAQVQSLD-CRLVAEPSGSESSMEQVLFPKP---GPLEPTQRLLSQLERGILVAS 283
Query: 320 APDGLYAKRLCQSRIYWDGPLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHGRSLP 379
P GL+ +RLC I W+ P A P+ L ++ +LF T F +L + P
Sbjct: 284 NPRGLFVQRLCPIPISWNAPQAPPGPGPHLLPSNECVELFRTAYFCRDLVRYFQGLGPPP 343
Query: 380 RFQVTLCFGEE-FPDPQRQRKLITAHVEPLLARQL 413
+FQVTL F EE + LIT +E AR L
Sbjct: 344 KFQVTLNFWEESHGSSHTPQNLITVKMEQAFARYL 378
>gi|4504727 interferon regulatory factor 5 isoform a [Homo sapiens]
Length = 504
Score = 205 bits (522), Expect = 6e-53
Identities = 153/461 (33%), Positives = 218/461 (47%), Gaps = 66/461 (14%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
+L+ WL+ Q++S +YPGL W N EK +F IPW+HA + +++ D +FKAWA GK+
Sbjct: 16 RLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYT 75
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIV-----------PEG 131
EG+D+ DP WK LRCALNKS DF + + + PYK+Y + PE
Sbjct: 76 EGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPED 135
Query: 132 AKKGAKQ--------------LTLEDPQMSMSH--PYTMTTPYPSLPAQQVHNYMMPPLD 175
GA + L+L D S H PY++ P + PP+
Sbjct: 136 YSFGAGEEEEEEEELQRMLPSLSLTDAVQSGPHMTPYSLLKEDVKWPPTLQPPTLQPPV- 194
Query: 176 RSWRDYVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPP--ESQAPGV 233
V P P+ P P G + G A PP E P +
Sbjct: 195 ------VLGPPAPDPSPLAPPPGNPAGFR----ELLSEVLEPGPLPASLPPAGEQLLPDL 244
Query: 234 PTEPSIRSAEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHGHT---------YDA 284
P + L +D L I YR + LT S+P GCR+ + +
Sbjct: 245 LISPHM-----LPLTD--LEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGP 297
Query: 285 SNLDQVLFPYPED---NGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLA 341
+L+QV FP PED + QR +LL L+RG++L + LYA RLCQ +++W GP A
Sbjct: 298 ISLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCA 357
Query: 342 LCNDR-PNKLERDQTCKLFDTQQFLSELQAFAH-HGRSLPRFQVTLCFGEEFPDPQ-RQR 398
+D PN ++R+ KLF + FL+EL F + P F++ CFGEE+PD + R++
Sbjct: 358 SAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREK 417
Query: 399 KLITAHVEPLLARQLYYFAQQNSGHFLRGYD-LPEHISNPE 438
KLIT V P+ AR L + SG D + ISNP+
Sbjct: 418 KLITVQVVPVAARLL---LEMFSGELSWSADSIRLQISNPD 455
>gi|148833494 interferon regulatory factor 5 isoform d [Homo
sapiens]
Length = 514
Score = 204 bits (519), Expect = 1e-52
Identities = 153/461 (33%), Positives = 219/461 (47%), Gaps = 56/461 (12%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
+L+ WL+ Q++S +YPGL W N EK +F IPW+HA + +++ D +FKAWA GK+
Sbjct: 16 RLKPWLVAQVNSCQYPGLQWVNGEKKLFCIPWRHATRHGPSQDGDNTIFKAWAKETGKYT 75
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIV-----------PEG 131
EG+D+ DP WK LRCALNKS DF + + + PYK+Y + PE
Sbjct: 76 EGVDEADPAKWKANLRCALNKSRDFRLIYDGPRDMPPQPYKIYEVCSNGPAPTDSQPPED 135
Query: 132 AKKGAKQ--------------LTLEDPQMSMSH--PYTMTTPYPSLPAQQVHNYMMPPLD 175
GA + L+L D S H PY++ P + PP
Sbjct: 136 YSFGAGEEEEEEEELQRMLPSLSLTDAVQSGPHMTPYSLLKEDVKWPPTLQPPTLRPPTL 195
Query: 176 RSWRDYVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPP--ESQAPGV 233
+ P P P P+ P G+ + G A PP E P +
Sbjct: 196 QPPTLQPPVVLGPPAPDPSPLA-PPPGNPAGFRELLSEVLEPGPLPASLPPAGEQLLPDL 254
Query: 234 PTEPSIRSAEALAFSDCRLHICLYYREILVKELTTSSPEGCRISHG---------HTYDA 284
P + L +D L I YR + LT S+P GCR+ + +
Sbjct: 255 LISPHM-----LPLTD--LEIKFQYRGRPPRALTISNPHGCRLFYSQLEATQEQVELFGP 307
Query: 285 SNLDQVLFPYPED---NGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWDGPLA 341
+L+QV FP PED + QR +LL L+RG++L + LYA RLCQ +++W GP A
Sbjct: 308 ISLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCA 367
Query: 342 LCNDR-PNKLERDQTCKLFDTQQFLSELQAFAH-HGRSLPRFQVTLCFGEEFPDPQ-RQR 398
+D PN ++R+ KLF + FL+EL F + P F++ CFGEE+PD + R++
Sbjct: 368 SAHDSCPNPIQREVKTKLFSLEHFLNELILFQKGQTNTPPPFEIFFCFGEEWPDRKPREK 427
Query: 399 KLITAHVEPLLARQLYYFAQQNSGHFLRGYD-LPEHISNPE 438
KLIT V P+ AR L + SG D + ISNP+
Sbjct: 428 KLITVQVVPVAARLL---LEMFSGELSWSADSIRLQISNPD 465
>gi|4504725 interferon regulatory factor 3 [Homo sapiens]
Length = 427
Score = 138 bits (347), Expect = 1e-32
Identities = 121/427 (28%), Positives = 179/427 (41%), Gaps = 49/427 (11%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
++ WL+ Q+D G+ G+ W N+ ++ FRIPWKH +QD ++ED +F+AWA G +
Sbjct: 7 RILPWLVSQLDLGQLEGVAWVNKSRTRFRIPWKHGLRQD-AQQEDFGIFQAWAEATGAYV 65
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQLTLE 142
G DKPD PTWK R ALN+ +RS+ D DP+K+Y V G ++ T
Sbjct: 66 PGRDKPDLPTWKRNFRSALNRKEGLRLAEDRSK-DPHDPHKIYEFVNSGVGDFSQPDTSP 124
Query: 143 DPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEI---PYQCPMTFG 199
D S T L + N ++ PL PD P + P CP
Sbjct: 125 DTNGGGSTSDTQEDILDEL----LGNMVLAPL--------PDPGPPSLAVAPEPCPQPL- 171
Query: 200 PRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYR 259
+ P+ +N F P E+ P + + E F + +YR
Sbjct: 172 ------RSPSLDN----PTPFPNLGPSEN-----PLKRLLVPGEEWEF-----EVTAFYR 211
Query: 260 EILVKELTTSSPEGCRISHGHTYDASNLD-QVLFPYP----EDNGQRKNIEKLLSHLERG 314
V + T S PEG R+ D + V P P D G + +LS L G
Sbjct: 212 GRQVFQQTISCPEGLRLVGSEVGDRTLPGWPVTLPDPGMSLTDRGVMSYVRHVLSCLGGG 271
Query: 315 VVLWMAPDGLYAKRLCQSRIYWDGPLALC----NDRPNKLERDQTCKLFDTQQFLSELQA 370
+ LW A L+A+RL YW L + ++ +D+ +FD F+ +L
Sbjct: 272 LALWRAGQWLWAQRLGHCHTYWAVSEELLPNSGHGPDGEVPKDKEGGVFDLGPFIVDLIT 331
Query: 371 FAHHGRSLPRFQVTLCFGEEFPDPQR-QRKLITAHVEPLLARQLYYFAQQNSGHFLRGYD 429
F PR+ + C GE +P Q ++L+ V P R L A+ L
Sbjct: 332 FTEGSGRSPRYALWFCVGESWPQDQPWTKRLVMVKVVPTCLRALVEMARVGGASSLEN-T 390
Query: 430 LPEHISN 436
+ HISN
Sbjct: 391 VDLHISN 397
>gi|98985819 interferon regulatory factor 7 isoform d [Homo sapiens]
Length = 516
Score = 121 bits (304), Expect = 1e-27
Identities = 127/448 (28%), Positives = 190/448 (42%), Gaps = 66/448 (14%)
Query: 26 QWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKF---- 81
+WL+ +I SG Y GL W +E ++ FR+PWKH ++D + E DA +FKAWA+ +G++
Sbjct: 29 EWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLS-EADARIFKAWAVARGRWPPSS 87
Query: 82 REGIDKPDPPT-----WKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKK-- 134
R G P+ T WKT RCAL + F L + S D +DP+KVY + E +
Sbjct: 88 RGGGPPPEAETAERAGWKTNFRCALRSTRRFVMLRDNSG-DPADPHKVYALSRELCWREG 146
Query: 135 -GAKQLTLE------DPQMSMSHPYTMTT--------PYPS---------LPAQQVHNYM 170
G Q E PQ P+ T P P+ L A Q
Sbjct: 147 PGTDQTEAEAPAAVPPPQGGPPGPFLAHTHAGLQAPGPLPAPAGDKGDLLLQAVQQSCLA 206
Query: 171 MPPLDRSW-RDYVPDQPHPEIPYQCPMTFGPRG---------HHW-----QGPACENGCQ 215
L SW D VP + E P+T G + W P +
Sbjct: 207 DHLLTASWGADPVPTKAPGEGQEGLPLTGACAGGPGLPAGELYGWAVETTPSPGPQPAAL 266
Query: 216 VTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREILVKELTTSSPEGCR 275
TG A P P + PS +A S L + + Y+ V + P C
Sbjct: 267 TTGEAAAPESPHQAEPYLSPSPSACTA-VQEPSPGALDVTIMYKGRTVLQKVVGHP-SCT 324
Query: 276 ISHG---HTYDASNLDQVLFPYP---EDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKRL 329
+G A++ QV FP P D Q + E+LL H+ G+ L + L+A+R+
Sbjct: 325 FLYGPPDPAVRATDPQQVAFPSPAELPDQKQLRYTEELLRHVAPGLHLELRGPQLWARRM 384
Query: 330 CQSRIYWD--GPLALCNDRPNK--LERDQTCKLFDTQQFLSELQAF-AHHGRSLPRFQVT 384
+ ++YW+ GP + L R+ +FD + F EL F A R PR+ +
Sbjct: 385 GKCKVYWEVGGPPGSASPSTPACLLPRNCDTPIFDFRVFFQELVEFRARQRRGSPRYTIY 444
Query: 385 LCFGEEFPDPQ-RQRKLITAHVEPLLAR 411
L FG++ + +++ L+ +EP L R
Sbjct: 445 LGFGQDLSAGRPKEKSLVLVKLEPWLCR 472
>gi|4758610 interferon regulatory factor 7 isoform a [Homo sapiens]
Length = 503
Score = 121 bits (304), Expect = 1e-27
Identities = 127/448 (28%), Positives = 190/448 (42%), Gaps = 66/448 (14%)
Query: 26 QWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKF---- 81
+WL+ +I SG Y GL W +E ++ FR+PWKH ++D + E DA +FKAWA+ +G++
Sbjct: 16 EWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLS-EADARIFKAWAVARGRWPPSS 74
Query: 82 REGIDKPDPPT-----WKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKK-- 134
R G P+ T WKT RCAL + F L + S D +DP+KVY + E +
Sbjct: 75 RGGGPPPEAETAERAGWKTNFRCALRSTRRFVMLRDNSG-DPADPHKVYALSRELCWREG 133
Query: 135 -GAKQLTLE------DPQMSMSHPYTMTT--------PYPS---------LPAQQVHNYM 170
G Q E PQ P+ T P P+ L A Q
Sbjct: 134 PGTDQTEAEAPAAVPPPQGGPPGPFLAHTHAGLQAPGPLPAPAGDKGDLLLQAVQQSCLA 193
Query: 171 MPPLDRSW-RDYVPDQPHPEIPYQCPMTFGPRG---------HHW-----QGPACENGCQ 215
L SW D VP + E P+T G + W P +
Sbjct: 194 DHLLTASWGADPVPTKAPGEGQEGLPLTGACAGGPGLPAGELYGWAVETTPSPGPQPAAL 253
Query: 216 VTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREILVKELTTSSPEGCR 275
TG A P P + PS +A S L + + Y+ V + P C
Sbjct: 254 TTGEAAAPESPHQAEPYLSPSPSACTA-VQEPSPGALDVTIMYKGRTVLQKVVGHP-SCT 311
Query: 276 ISHG---HTYDASNLDQVLFPYP---EDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKRL 329
+G A++ QV FP P D Q + E+LL H+ G+ L + L+A+R+
Sbjct: 312 FLYGPPDPAVRATDPQQVAFPSPAELPDQKQLRYTEELLRHVAPGLHLELRGPQLWARRM 371
Query: 330 CQSRIYWD--GPLALCNDRPNK--LERDQTCKLFDTQQFLSELQAF-AHHGRSLPRFQVT 384
+ ++YW+ GP + L R+ +FD + F EL F A R PR+ +
Sbjct: 372 GKCKVYWEVGGPPGSASPSTPACLLPRNCDTPIFDFRVFFQELVEFRARQRRGSPRYTIY 431
Query: 385 LCFGEEFPDPQ-RQRKLITAHVEPLLAR 411
L FG++ + +++ L+ +EP L R
Sbjct: 432 LGFGQDLSAGRPKEKSLVLVKLEPWLCR 459
>gi|153082752 interferon regulatory factor 2 [Homo sapiens]
Length = 349
Score = 121 bits (303), Expect = 1e-27
Identities = 55/127 (43%), Positives = 84/127 (66%), Gaps = 3/127 (2%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
++R WL +QI+S PGL W N+EK IF+IPW HA + ++ E+DA LF+ WA+ GK +
Sbjct: 7 RMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQ 66
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVP---EGAKKGAKQL 139
G+DKPDP TWK RCA+N D EE+ ++S ++ ++VYR++P +KKG K
Sbjct: 67 PGVDKPDPKTWKANFRCAMNSLPDIEEVKDKSIKKGNNAFRVYRMLPLSERPSKKGKKPK 126
Query: 140 TLEDPQM 146
T ++ ++
Sbjct: 127 TEKEDKV 133
>gi|4809284 interferon regulatory factor 7 isoform b [Homo sapiens]
Length = 474
Score = 121 bits (303), Expect = 1e-27
Identities = 123/432 (28%), Positives = 194/432 (44%), Gaps = 63/432 (14%)
Query: 26 QWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKF---- 81
+WL+ +I SG Y GL W +E ++ FR+PWKH ++D + E DA +FKAWA+ +G++
Sbjct: 16 EWLLGEISSGCYEGLQWLDEARTCFRVPWKHFARKDLS-EADARIFKAWAVARGRWPPSS 74
Query: 82 REGIDKPDPPT-----WKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKK-- 134
R G P+ T WKT RCAL + F L + S D +DP+KVY + E +
Sbjct: 75 RGGGPPPEAETAERAGWKTNFRCALRSTRRFVMLRDNSG-DPADPHKVYALSRELCWREG 133
Query: 135 -GAKQLTLE------DPQMSMSHPYTMTT--------PYPSLPAQQVHNYMMPPLDRS-W 178
G Q E PQ P+ T P P+ PA + ++ + +S
Sbjct: 134 PGTDQTEAEAPAAVPPPQGGPPGPFLAHTHAGLQAPGPLPA-PAGDKGDLLLQAVQQSCL 192
Query: 179 RDYVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVP--TE 236
D++ P P +G + G +TG ACA E+ AP P E
Sbjct: 193 ADHLLTASWGADPV-------PTKAPGEG---QEGLPLTG---ACAGGEAAAPESPHQAE 239
Query: 237 PSIRSAEALAF-----SDCRLHICLYYREILVKELTTSSPEGCRISHG---HTYDASNLD 288
P + + + S L + + Y+ V + P C +G A++
Sbjct: 240 PYLSPSPSACTAVQEPSPGALDVTIMYKGRTVLQKVVGHP-SCTFLYGPPDPAVRATDPQ 298
Query: 289 QVLFPYP---EDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKRLCQSRIYWD--GPLALC 343
QV FP P D Q + E+LL H+ G+ L + L+A+R+ + ++YW+ GP
Sbjct: 299 QVAFPSPAELPDQKQLRYTEELLRHVAPGLHLELRGPQLWARRMGKCKVYWEVGGPPGSA 358
Query: 344 NDRPNK--LERDQTCKLFDTQQFLSELQAF-AHHGRSLPRFQVTLCFGEEFPDPQ-RQRK 399
+ L R+ +FD + F EL F A R PR+ + L FG++ + +++
Sbjct: 359 SPSTPACLLPRNCDTPIFDFRVFFQELVEFRARQRRGSPRYTIYLGFGQDLSAGRPKEKS 418
Query: 400 LITAHVEPLLAR 411
L+ +EP L R
Sbjct: 419 LVLVKLEPWLCR 430
>gi|4504721 interferon regulatory factor 1 [Homo sapiens]
Length = 325
Score = 115 bits (289), Expect = 6e-26
Identities = 50/116 (43%), Positives = 77/116 (66%)
Query: 23 KLRQWLIDQIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFR 82
++R WL QI+S + PGL+W N+E+ IF+IPWKHA K ++ +DA LF++WA+ G+++
Sbjct: 7 RMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYK 66
Query: 83 EGIDKPDPPTWKTRLRCALNKSNDFEELVERSQLDISDPYKVYRIVPEGAKKGAKQ 138
G +PDP TWK RCA+N D EE+ ++S+ S +VYR++P K K+
Sbjct: 67 AGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTKNQRKE 122
>gi|239757474 PREDICTED: similar to hCG1785205 [Homo sapiens]
Length = 362
Score = 62.8 bits (151), Expect = 6e-10
Identities = 30/61 (49%), Positives = 37/61 (60%), Gaps = 9/61 (14%)
Query: 31 QIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDP 90
QI+SG Y GL WE+ K++FRIPWKH KQ Y +AW + KGK EG +K P
Sbjct: 16 QIESGCYVGLCWEDAGKTLFRIPWKHVAKQGY---------QAWMVHKGKHLEGTNKEAP 66
Query: 91 P 91
P
Sbjct: 67 P 67
Score = 40.8 bits (94), Expect = 0.003
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 24/85 (28%)
Query: 346 RPNKLERDQTCKLFDTQQFLSELQAFAHHGRSL----------------------PRFQV 383
+PNK+ER +TC L +T+ FL + R P++Q+
Sbjct: 227 QPNKVERRRTCHLLNTRGFLQAVGRLEEWNRVAWERGHKDACRIIVCPPAGWSPDPKYQI 286
Query: 384 TLCFGEEFPDPQRQRK--LITAHVE 406
LCFGEE P P + K LI A V+
Sbjct: 287 CLCFGEEDPGPTQHPKEQLIMADVQ 311
>gi|239751984 PREDICTED: similar to hCG1785205 [Homo sapiens]
Length = 362
Score = 62.8 bits (151), Expect = 6e-10
Identities = 30/61 (49%), Positives = 37/61 (60%), Gaps = 9/61 (14%)
Query: 31 QIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDP 90
QI+SG Y GL WE+ K++FRIPWKH KQ Y +AW + KGK EG +K P
Sbjct: 16 QIESGCYVGLCWEDAGKTLFRIPWKHVAKQGY---------QAWMVHKGKHLEGTNKEAP 66
Query: 91 P 91
P
Sbjct: 67 P 67
Score = 40.8 bits (94), Expect = 0.003
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 24/85 (28%)
Query: 346 RPNKLERDQTCKLFDTQQFLSELQAFAHHGRSL----------------------PRFQV 383
+PNK+ER +TC L +T+ FL + R P++Q+
Sbjct: 227 QPNKVERRRTCHLLNTRGFLQAVGRLEEWNRVAWERGHKDACRIIVCPPAGWSPDPKYQI 286
Query: 384 TLCFGEEFPDPQRQRK--LITAHVE 406
LCFGEE P P + K LI A V+
Sbjct: 287 CLCFGEEDPGPTQHPKEQLIMADVQ 311
>gi|239746471 PREDICTED: hypothetical protein XP_002343764 [Homo
sapiens]
Length = 362
Score = 62.8 bits (151), Expect = 6e-10
Identities = 30/61 (49%), Positives = 37/61 (60%), Gaps = 9/61 (14%)
Query: 31 QIDSGKYPGLVWENEEKSIFRIPWKHAGKQDYNREEDAALFKAWALFKGKFREGIDKPDP 90
QI+SG Y GL WE+ K++FRIPWKH KQ Y +AW + KGK EG +K P
Sbjct: 16 QIESGCYVGLCWEDAGKTLFRIPWKHVAKQGY---------QAWMVHKGKHLEGTNKEAP 66
Query: 91 P 91
P
Sbjct: 67 P 67
Score = 40.8 bits (94), Expect = 0.003
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 24/85 (28%)
Query: 346 RPNKLERDQTCKLFDTQQFLSELQAFAHHGRSL----------------------PRFQV 383
+PNK+ER +TC L +T+ FL + R P++Q+
Sbjct: 227 QPNKVERRRTCHLLNTRGFLQAVGRLEEWNRVAWERGHKDACRIIVCPPAGWSPDPKYQI 286
Query: 384 TLCFGEEFPDPQRQRK--LITAHVE 406
LCFGEE P P + K LI A V+
Sbjct: 287 CLCFGEEDPGPTQHPKEQLIMADVQ 311
>gi|51173727 Sma- and Mad-related protein 1 [Homo sapiens]
Length = 465
Score = 44.7 bits (104), Expect = 2e-04
Identities = 53/246 (21%), Positives = 94/246 (38%), Gaps = 38/246 (15%)
Query: 145 QMSMSHPY--TMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRG 202
Q SHP+ + + YP+ P Y + P P P+Q P P
Sbjct: 177 QQPNSHPFPHSPNSSYPNSPGSSSSTY----------PHSPTSSDPGSPFQMPADTPPPA 226
Query: 203 H-HWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREI 261
+ + P ++G Q T AP +P+E + +A+A+ + + + Y E+
Sbjct: 227 YLPPEDPMTQDGSQPMDT-------NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYEL 279
Query: 262 --LVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWM 319
V E +S + G T ++N ++ + + IE H+ +GV L+
Sbjct: 280 NNRVGEAFHASSTSVLVD-GFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYY 338
Query: 320 APDGLYAKRLCQSRIYWDG----------PLALCNDRPNKLERDQTCKLFDTQQFLSELQ 369
+YA+ L S I+ P +C K+ + K+F+ Q+F L
Sbjct: 339 VGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVC-----KIPSGCSLKIFNNQEFAQLLA 393
Query: 370 AFAHHG 375
+HG
Sbjct: 394 QSVNHG 399
>gi|5174509 Sma- and Mad-related protein 1 [Homo sapiens]
Length = 465
Score = 44.7 bits (104), Expect = 2e-04
Identities = 53/246 (21%), Positives = 94/246 (38%), Gaps = 38/246 (15%)
Query: 145 QMSMSHPY--TMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRG 202
Q SHP+ + + YP+ P Y + P P P+Q P P
Sbjct: 177 QQPNSHPFPHSPNSSYPNSPGSSSSTY----------PHSPTSSDPGSPFQMPADTPPPA 226
Query: 203 H-HWQGPACENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREI 261
+ + P ++G Q T AP +P+E + +A+A+ + + + Y E+
Sbjct: 227 YLPPEDPMTQDGSQPMDT-------NMMAPPLPSEINRGDVQAVAYEEPKHWCSIVYYEL 279
Query: 262 --LVKELTTSSPEGCRISHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWM 319
V E +S + G T ++N ++ + + IE H+ +GV L+
Sbjct: 280 NNRVGEAFHASSTSVLVD-GFTDPSNNKNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYY 338
Query: 320 APDGLYAKRLCQSRIYWDG----------PLALCNDRPNKLERDQTCKLFDTQQFLSELQ 369
+YA+ L S I+ P +C K+ + K+F+ Q+F L
Sbjct: 339 VGGEVYAECLSDSSIFVQSRNCNYHHGFHPTTVC-----KIPSGCSLKIFNNQEFAQLLA 393
Query: 370 AFAHHG 375
+HG
Sbjct: 394 QSVNHG 399
>gi|118421085 leucine-rich repeat kinase 1 [Homo sapiens]
Length = 1910
Score = 33.5 bits (75), Expect = 0.40
Identities = 27/101 (26%), Positives = 39/101 (38%), Gaps = 24/101 (23%)
Query: 138 QLTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMT 197
+L ++PQMS S +++ P PS P + R+ D VP P ++ +C T
Sbjct: 1337 ELDQKEPQMSPSVAASLSCPVPSTPPEL--------SQRATLDTVPPPPPSKVGKRCRKT 1388
Query: 198 FGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEPS 238
PR + C P S PGV T S
Sbjct: 1389 SDPR----------------RSIVECQPDASATPGVGTADS 1413
>gi|239048862 checkpoint with forkhead and ring finger domains
isoform 2 [Homo sapiens]
Length = 663
Score = 32.7 bits (73), Expect = 0.69
Identities = 37/137 (27%), Positives = 50/137 (36%), Gaps = 22/137 (16%)
Query: 104 SNDFEEL--VERSQLDISDPYKVYRIVPEGAKKGAKQLTLEDPQMSMSHPYTM-TTPYPS 160
S D EL V+ DIS PY V R PE ++ A+ P+ P + P S
Sbjct: 405 SEDLLELSDVDSESSDISQPYVVCRQCPEYRRQAAQPPHCPAPEGEPGAPQALGDAPSTS 464
Query: 161 LPAQQVHNYMMPPLDRSWRDYVPDQPHPE-----------IPYQCPMTFGPRGH-HWQGP 208
+ V +Y+ P QP P+ P QC + P H +W
Sbjct: 465 VSLTTVQDYVCPLQGSHALCTCCFQPMPDRRAEREQDPRVAPQQCAVCLQPFCHLYW--- 521
Query: 209 ACENGCQVTGTFYACAP 225
GC TG + AP
Sbjct: 522 ----GCTRTGCYGCLAP 534
>gi|187828357 SMAD family member 9 isoform a [Homo sapiens]
Length = 467
Score = 32.7 bits (73), Expect = 0.69
Identities = 52/237 (21%), Positives = 81/237 (34%), Gaps = 38/237 (16%)
Query: 157 PYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRGHH-WQGPACENGCQ 215
P +LP H + P S+ PE PYQ + P +H + ++G
Sbjct: 185 PCSALPPSPSHAFSQSPCTASYPHSPGSPSEPESPYQHSVDTPPLPYHATEASETQSGQP 244
Query: 216 VTGT----FYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHIC-LYYREI--LVKELTT 268
V T P P EP H C + Y E+ V E
Sbjct: 245 VDATADRHVVLSIPNGDFRPVCYEEPQ--------------HWCSVAYYELNNRVGETFQ 290
Query: 269 SSPEGCRISHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKR 328
+S I G T ++N ++ + + IE H+ +GV L+ +YA+
Sbjct: 291 ASSRSVLID-GFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAEC 349
Query: 329 LCQSRIYWDG----------PLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHG 375
+ S I+ P +C K+ + K+F+ Q F L HHG
Sbjct: 350 VSDSSIFVQSRNCNYQHGFHPATVC-----KIPSGCSLKVFNNQLFAQLLAQSVHHG 401
>gi|47778931 SMAD, mothers against DPP homolog 5 [Homo sapiens]
Length = 465
Score = 32.3 bits (72), Expect = 0.90
Identities = 47/237 (19%), Positives = 82/237 (34%), Gaps = 35/237 (14%)
Query: 151 PYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRGHHWQGPAC 210
P + +PYP PA + P P P+Q P P + P
Sbjct: 186 PLSPNSPYPPSPASSTYPNS------------PASSGPGSPFQLPADTPPPAY--MPPDD 231
Query: 211 ENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREI--LVKELTT 268
+ G + P + S R + +A+ + + + Y E+ V E
Sbjct: 232 QMG---QDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFH 288
Query: 269 SSPEGCRISHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKR 328
+S + G T ++N + + + IE H+ +GV L+ +YA+
Sbjct: 289 ASSTSVLVD-GFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAEC 347
Query: 329 LCQSRIYWDG----------PLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHG 375
L S I+ P +C K+ + K+F+ Q+F L +HG
Sbjct: 348 LSDSSIFVQSRNCNFHHGFHPTTVC-----KIPSSCSLKIFNNQEFAQLLAQSVNHG 399
>gi|47778929 SMAD, mothers against DPP homolog 5 [Homo sapiens]
Length = 465
Score = 32.3 bits (72), Expect = 0.90
Identities = 47/237 (19%), Positives = 82/237 (34%), Gaps = 35/237 (14%)
Query: 151 PYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRGHHWQGPAC 210
P + +PYP PA + P P P+Q P P + P
Sbjct: 186 PLSPNSPYPPSPASSTYPNS------------PASSGPGSPFQLPADTPPPAY--MPPDD 231
Query: 211 ENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREI--LVKELTT 268
+ G + P + S R + +A+ + + + Y E+ V E
Sbjct: 232 QMG---QDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFH 288
Query: 269 SSPEGCRISHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKR 328
+S + G T ++N + + + IE H+ +GV L+ +YA+
Sbjct: 289 ASSTSVLVD-GFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAEC 347
Query: 329 LCQSRIYWDG----------PLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHG 375
L S I+ P +C K+ + K+F+ Q+F L +HG
Sbjct: 348 LSDSSIFVQSRNCNFHHGFHPTTVC-----KIPSSCSLKIFNNQEFAQLLAQSVNHG 399
>gi|47778925 SMAD, mothers against DPP homolog 5 [Homo sapiens]
Length = 465
Score = 32.3 bits (72), Expect = 0.90
Identities = 47/237 (19%), Positives = 82/237 (34%), Gaps = 35/237 (14%)
Query: 151 PYTMTTPYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRGHHWQGPAC 210
P + +PYP PA + P P P+Q P P + P
Sbjct: 186 PLSPNSPYPPSPASSTYPNS------------PASSGPGSPFQLPADTPPPAY--MPPDD 231
Query: 211 ENGCQVTGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREI--LVKELTT 268
+ G + P + S R + +A+ + + + Y E+ V E
Sbjct: 232 QMG---QDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFH 288
Query: 269 SSPEGCRISHGHTYDASNLDQVLFPYPEDNGQRKNIEKLLSHLERGVVLWMAPDGLYAKR 328
+S + G T ++N + + + IE H+ +GV L+ +YA+
Sbjct: 289 ASSTSVLVD-GFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAEC 347
Query: 329 LCQSRIYWDG----------PLALCNDRPNKLERDQTCKLFDTQQFLSELQAFAHHG 375
L S I+ P +C K+ + K+F+ Q+F L +HG
Sbjct: 348 LSDSSIFVQSRNCNFHHGFHPTTVC-----KIPSSCSLKIFNNQEFAQLLAQSVNHG 399
>gi|239047795 pleckstrin homology domain containing, family A member
7 [Homo sapiens]
Length = 1121
Score = 32.0 bits (71), Expect = 1.2
Identities = 31/116 (26%), Positives = 43/116 (37%), Gaps = 5/116 (4%)
Query: 125 YRIVPEGAKKGAKQ---LTLEDPQMSMSHPYTMTTPYPSLPAQQVHNYMMPPLDRSWRDY 181
+RI+ E K ++ L P S+S + P PS P V + L + Y
Sbjct: 829 FRILVESVKNPERKTVPLFPHPPVPSLSTSESKPPPQPSPPTSPVRTPLEVRLFPQLQTY 888
Query: 182 VPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQVTGTFYACAPPESQAPGVPTEP 237
VP +PHP P +T + P E+ PE Q P VP P
Sbjct: 889 VPYRPHP--PQLRKVTSPLQSPTKAKPKVEDEAPPRPPLPELYSPEDQPPAVPPLP 942
>gi|239750586 PREDICTED: hypothetical protein XP_002347439 [Homo
sapiens]
Length = 300
Score = 32.0 bits (71), Expect = 1.2
Identities = 38/142 (26%), Positives = 54/142 (38%), Gaps = 24/142 (16%)
Query: 157 PYPSLPAQQVHNYMMPPLDRSWRDYVPDQPHPEIPYQCPMTFGPRGHHWQGPACENGCQV 216
P+P +P P R W + V Q P PRG W P +G V
Sbjct: 109 PFPPVPGLHALLVCGQPRSREWTERV----------QLP----PRGRAWPPPPFTSGRPV 154
Query: 217 TGTFYACAPPESQAPGVPTEPSIRSAEALAFSDCRLHICLYYREILVKELTTSSPEGCRI 276
G A A +AP V + R+A ++ S+ C+++ I ++ TS P R
Sbjct: 155 AGVEAAEAAAAQRAPSV-WPHATRAAPSIPASN---RACVHHSSI--RQQCTSIPASNRA 208
Query: 277 SHGHTYDASNLDQVLFPYPEDN 298
S H S + Q PE N
Sbjct: 209 SVYH----SGIWQQCTSIPESN 226
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.443
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,717,637
Number of Sequences: 37866
Number of extensions: 1129335
Number of successful extensions: 2738
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 2640
Number of HSP's gapped (non-prelim): 70
length of query: 451
length of database: 18,247,518
effective HSP length: 106
effective length of query: 345
effective length of database: 14,233,722
effective search space: 4910634090
effective search space used: 4910634090
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.