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Search of human proteins with 166362713
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens]
(784 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens] 1580 0.0
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 549 e-156
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 538 e-153
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 536 e-152
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens] 531 e-151
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 530 e-150
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 530 e-150
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] 527 e-149
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 513 e-145
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 513 e-145
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens] 509 e-144
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 499 e-141
gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens] 494 e-139
gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens] 480 e-135
gi|16753221 cadherin 22 precursor [Homo sapiens] 464 e-130
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 354 2e-97
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 350 4e-96
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 328 9e-90
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens] 306 4e-83
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens] 284 3e-76
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 219 6e-57
gi|29570800 cadherin-like 26 isoform a [Homo sapiens] 212 1e-54
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 201 2e-51
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens] 199 6e-51
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi... 199 6e-51
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 193 6e-49
gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo ... 191 3e-48
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 186 9e-47
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 185 2e-46
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 182 1e-45
>gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens]
Length = 784
Score = 1580 bits (4091), Expect = 0.0
Identities = 784/784 (100%), Positives = 784/784 (100%)
Query: 1 MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEK 60
MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEK
Sbjct: 1 MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEK 60
Query: 61 NTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTA 120
NTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTA
Sbjct: 61 NTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTA 120
Query: 121 VIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADD 180
VIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADD
Sbjct: 121 VIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADD 180
Query: 181 PTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSG 240
PTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSG
Sbjct: 181 PTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSG 240
Query: 241 TATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRG 300
TATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRG
Sbjct: 241 TATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRG 300
Query: 301 DYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVI 360
DYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVI
Sbjct: 301 DYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVI 360
Query: 361 INITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFR 420
INITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFR
Sbjct: 361 INITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFR 420
Query: 421 VTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFA 480
VTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFA
Sbjct: 421 VTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFA 480
Query: 481 KPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKY 540
KPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKY
Sbjct: 481 KPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKY 540
Query: 541 GQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQA 600
GQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQA
Sbjct: 541 GQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQA 600
Query: 601 VVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDV 660
VVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDV
Sbjct: 601 VVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDV 660
Query: 661 SVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDG 720
SVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDG
Sbjct: 661 SVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDG 720
Query: 721 DGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPRE 780
DGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPRE
Sbjct: 721 DGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPRE 780
Query: 781 ELLY 784
ELLY
Sbjct: 781 ELLY 784
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 549 bits (1415), Expect = e-156
Identities = 321/783 (40%), Positives = 459/783 (58%), Gaps = 35/783 (4%)
Query: 16 GLLAVAAVAAAGANPAQRDTHSLLP----THRRQKRDWIWNQMHIDEEKNTSLPHHVGKI 71
GL+ + + Q + +LL +H+R KR W+WNQ + EE + P +VGK+
Sbjct: 24 GLMDLTTTVLSDTPTPQGELEALLSDKPQSHQRTKRSWVWNQFFVLEEYTGTDPLYVGKL 83
Query: 72 KSSVSRKNA--KYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGE 129
S + R + KY+L GE G VF +D TGD+ AI+RLDRE ++Y L A +D+ TG
Sbjct: 84 HSDMDRGDGSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRTGR 143
Query: 130 NLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASV 189
+E S F IK+ D+NDN P F + A+VPE S VGTSVI VTA DADDPT G+ A V
Sbjct: 144 PMEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTATDADDPTYGNSARV 203
Query: 190 MYQILKGKEYFAIDN-SGRIITITKSLDREKQARYEIVVEARDAQG-LRGDSGTATVLVT 247
+Y IL+G+ YF++D+ +G I T ++DRE + YE++++A+D G L G +GT TV +T
Sbjct: 204 VYSILQGQPYFSVDSKTGVIRTALMNMDREAKEYYEVIIQAKDMGGQLGGLAGTTTVNIT 263
Query: 248 LQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFT 307
L D+NDN P F Q Y V E + ++VG +F +D DE N KY+I+ GD DAF
Sbjct: 264 LSDVNDNPPRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFD 323
Query: 308 IETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS-PPAGNRAQVIINITDV 366
I T+P GII KPL +E + Y+ VE +P +++R+++ P + V I++ DV
Sbjct: 324 ISTDPNFQVGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQDTTTVHISVEDV 383
Query: 367 DEPPIFQQPFYHFQLKENQKKPLIGTVL----AMDPDAARHSIGYSIRRTSDKGQFFRV- 421
DEPP+F+ FY ++ E+ IGT + A DPD +SI YSI R+SD G+FF V
Sbjct: 384 DEPPVFEPGFYFVEVPED---VAIGTTIQIISAKDPDVTNNSIRYSIDRSSDPGRFFYVD 440
Query: 422 TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAK 481
G + + LDRE + W+N+TV A E+++ + V V I+VLD NDNAPEF +
Sbjct: 441 ITTGALMTARPLDREEFSWHNITVLAMEMNN----PSQVGSVPVTIKVLDVNDNAPEFPR 496
Query: 482 PYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTE----NNFTLTDNHDNTANIT 537
Y+ VCENA GQL+ +SA+D+D F + L E NFT+ DN DNTA I
Sbjct: 497 FYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNTARIL 556
Query: 538 VKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVS 597
+ F ++ V LP++I+D+G P + T TLT+ VC C++ G C A + VS
Sbjct: 557 TRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAYMLPVS 616
Query: 598 IQ--AVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDT 655
+ A++AIL CI + V+ LLI RR RKQ IHE +V YD+EGGGE DT
Sbjct: 617 LSRGALIAILACIFVLLVLVLLILSMRRHRKQPYIIDDE-ENIHENIVRYDDEGGGEEDT 675
Query: 656 TSYDVSVLNSVR--RGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKK 713
++D++ + + R + GA P R + +++ R+ P + + + K
Sbjct: 676 EAFDIAAMWNPREAQAGAAP-----KTRQDMLPEIESLSRYVPQTCAVNSTVHSYVLAKL 730
Query: 714 DEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAEL 773
EAD D PP+D+L Y +EG S+A SLSSL + +SDS+ +DFL DWGPRF+ LAEL
Sbjct: 731 YEADMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAEL 790
Query: 774 YGS 776
YG+
Sbjct: 791 YGA 793
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 538 bits (1387), Expect = e-153
Identities = 315/753 (41%), Positives = 447/753 (59%), Gaps = 32/753 (4%)
Query: 43 RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRK--NAKYLLKGEYVGKVFRVDAETG 100
+R KR W+WNQ + EE P VG++ S + N KY+L GE G +F +D ++G
Sbjct: 49 QRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIFVIDDKSG 108
Query: 101 DVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASV 160
++ A + LDRE ++Y L A VD+DT LE PS F +KV D+NDN P F H ++A+V
Sbjct: 109 NIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLHETYHANV 168
Query: 161 PESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDREK 219
PE S VGTSVI VTA DADDPT G+ A ++Y IL+G+ YF+++ +G I T ++DRE
Sbjct: 169 PERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTALPNMDREA 228
Query: 220 QARYEIVVEARDAQG-LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVG 278
+ Y +V++A+D G + G SGT V +TL D+NDN P F Q+ Y V E G VG
Sbjct: 229 KEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAAVPGEEVG 288
Query: 279 SLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVE 338
+ +DPD +N + Y+I+ GD ++F I T+ EG+IK KP+D+E + YS VE
Sbjct: 289 RVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKRAYSLKVE 348
Query: 339 ATDPTIDLRYMS-PPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKK-PLIGTVLAM 396
A + ID +++S P + V I++ D DEPP+F P Y +++EN ++G V A
Sbjct: 349 AANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTVVGRVHAK 408
Query: 397 DPDAARHSIGYSIRRTSDKGQFFRVT-KKGDIYNEKELDREVYPWYNLTVEAKELDSTGT 455
DPDAA I YSI R +D +FF + + G I K LDRE W N+TV A E+ +
Sbjct: 409 DPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAAEIHN--- 465
Query: 456 PTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCEN----AVHGQLVLQISAIDKDITPRN 511
+E+ V V I VLD NDNAP+FA PY+ +CE+ + Q ++ ISA DKD T
Sbjct: 466 -RHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDTANG 524
Query: 512 VKFKFILNTE----NNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTG 567
+F F L E NFT+ DN DNTA + + G F R+ ++ LP+VISD G+P +
Sbjct: 525 PRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPPMSS 584
Query: 568 TSTLTVAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLR 625
T+TLT+ VC C+ G C E G+S A++AIL CI+ + VI +L RR +
Sbjct: 585 TNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLRRQK 644
Query: 626 KQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLY 685
K+ + ++ E ++TYD+EGGGE DT ++D++ L + G P D +P
Sbjct: 645 KEPLIVFEE-EDVRENIITYDDEGGGEEDTEAFDIATLQN--PDGINGFIPRKDIKP--- 698
Query: 686 AQVQKPPRHAPGAHGGPG--EMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESL 743
+ Q PR PG P ++ I + EAD+D PPYD++ IYGYEG S+A SL
Sbjct: 699 -EYQYMPR--PGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSL 755
Query: 744 SSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGS 776
SSL + ++DSD+DYD+L +WGPRFK LA+LYGS
Sbjct: 756 SSLESATTDSDLDYDYLQNWGPRFKKLADLYGS 788
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 536 bits (1382), Expect = e-152
Identities = 309/747 (41%), Positives = 430/747 (57%), Gaps = 25/747 (3%)
Query: 42 HRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAET 99
H R KR W+WNQ + EE P +VGK+ S+ + + KY+L GE G +F +D T
Sbjct: 48 HHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFIIDDTT 107
Query: 100 GDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNAS 159
GD+ + + LDRE + Y L A +D+ T + LE S F IKV D+NDN P FT + +
Sbjct: 108 GDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVT 167
Query: 160 VPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDRE 218
VPE S +GTSV+ VTA DADDPT G+ A V+Y IL+G+ YF++D +G I T ++DRE
Sbjct: 168 VPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDRE 227
Query: 219 KQARYEIVVEARDAQG-LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSV 277
+ Y +V++A+D G + G SG+ TV +TL D+NDN P F Q Y VPE +VG++V
Sbjct: 228 AREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVGSAV 287
Query: 278 GSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIV 337
G + D D N YSI+ GD F+I T+ EGI+ KPL+YE + Y+ +
Sbjct: 288 GKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNI 347
Query: 338 EATDPTIDLRYMS-PPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQK-KPLIGTVLA 395
E + +D R+ P + + I + DVDEPP+F P Y ++ EN K ++GTVLA
Sbjct: 348 EGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLA 407
Query: 396 MDPDAARHSIGYSIRRTSDKGQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTG 454
DPD+ + Y I + +FF + G I K LDRE PWYN+TV A E+D+
Sbjct: 408 QDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPD 467
Query: 455 TPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKF 514
S V V I VLD NDN PE A+ Y VCEN+ GQ++ ISA DKD +F
Sbjct: 468 L----LSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRF 523
Query: 515 KFILN----TENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTST 570
F L+ NFTL DN DNTA+I + +F R V++LP++ISD G+PS + +ST
Sbjct: 524 NFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSST 583
Query: 571 LTVAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQA 628
LT+ VC C G C E + G+S A++AILLC+L + I +L RR +K+
Sbjct: 584 LTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEP 643
Query: 629 RAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQV 688
S ++ E +VTYD+EGGGE DT ++D++ L + A+ + D RP +V
Sbjct: 644 LI--ISEEDVRENVVTYDDEGGGEEDTEAFDITALRN--PSAAEELKYRRDIRP----EV 695
Query: 689 QKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGT 748
+ PRH + ++ I+ + EAD D PPYD+L Y YEG S A S+SSL +
Sbjct: 696 KLTPRHQTSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDS 755
Query: 749 DSSDSDVDYDFLNDWGPRFKMLAELYG 775
++ SD DY +L DWGP FK LAELYG
Sbjct: 756 ATTQSDQDYHYLGDWGPEFKKLAELYG 782
>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
Length = 789
Score = 531 bits (1369), Expect = e-151
Identities = 308/751 (41%), Positives = 443/751 (58%), Gaps = 31/751 (4%)
Query: 43 RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRK--NAKYLLKGEYVGKVFRVDAETG 100
RR KR W+WNQ + EE + +VGK+ + + N KY+L G+ G +F +D TG
Sbjct: 49 RRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFVIDENTG 108
Query: 101 DVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASV 160
D+ A ++LDRE S Y L A +D+ TG +E S F IK+HD+NDN P FT L+ ASV
Sbjct: 109 DIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKDLYTASV 168
Query: 161 PESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDREK 219
PE S VGTSVI VTA DADD G+ A V+Y IL+G+ YF++D SG I T + RE
Sbjct: 169 PEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALPDMSREN 228
Query: 220 QARYEIVVEARDAQG-LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVG 278
+ +Y++V++A+D G + G SGT TV +TL D+N+N P F Q+ Y F PE +GT +G
Sbjct: 229 REQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVPLGTHLG 288
Query: 279 SLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVE 338
+ DPD +N +YSI GD D F + T+ EGII + LD+E Y+ V+
Sbjct: 289 RIKANDPDVGENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQMLYTLRVD 348
Query: 339 ATDPTIDLRYMS-PPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKK-PLIGTVLAM 396
A++ D R++ P + A V I++ D+DEPP+F + Y ++ E+ K+ +IG V A
Sbjct: 349 ASNTHPDPRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSIIGQVTAY 408
Query: 397 DPDAARHSIGYSIRRTSDKGQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGT 455
DPDA + I YS+ R +D + F + ++ G I+ K LDRE PW+N+TV A E+++
Sbjct: 409 DPDARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATEINN--- 465
Query: 456 PTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKF- 514
+ S + V I +LD ND+APEFA Y+ VCENA GQL+ +S +DKD PR KF
Sbjct: 466 -PKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHKFF 524
Query: 515 -----KFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTS 569
+F LN NFT+ DN DNTA I + + R + LP++I DN P ++ T
Sbjct: 525 FEPVPEFTLNP--NFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTG 582
Query: 570 TLTVAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQ 627
TLT+ VC C+ QG C E + G+S A+VAILLC+L + ++ +L +R RK+
Sbjct: 583 TLTIRVCACDNQGNMQSCTAEALILSAGLSTGALVAILLCVLILLILVVLFAALKRQRKK 642
Query: 628 ARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVL-NSVRRGGAKPPRPALDARPSLYA 686
S ++ + +VTY++EGGGE DT ++D+ L N R +K R D P
Sbjct: 643 EPLI-ISKDDVRDNIVTYNDEGGGEEDTQAFDIGTLRNPEAREDSKLRR---DVMPETIF 698
Query: 687 QVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSL 746
Q+++ ++ I + E D D PPYD+L Y YEG++SIA+SLSSL
Sbjct: 699 QIRRTVPLWENI-----DVQDFIHRRLKENDADPSAPPYDSLATYAYEGNDSIADSLSSL 753
Query: 747 GTDSSDSDVDYDFLNDWGPRFKMLAELYGSD 777
+ ++D + DYD+L+DWGPRFK LA++YG D
Sbjct: 754 ESLTADCNQDYDYLSDWGPRFKKLADMYGGD 784
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 530 bits (1365), Expect = e-150
Identities = 314/761 (41%), Positives = 442/761 (58%), Gaps = 27/761 (3%)
Query: 30 PAQRDTHSLLPTH-----RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNA--KY 82
P QR S +P RQKR W+WNQ + EE S +VGK+ S + + KY
Sbjct: 32 PQQRILSSRVPRSDGKILHRQKRGWMWNQFFLLEEYTGSDYQYVGKLHSDQDKGDGSLKY 91
Query: 83 LLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVH 142
+L G+ G +F +D +TGD+ A R+DRE + Y L A +++ T +E S F IK+H
Sbjct: 92 ILSGDGAGTLFIIDEKTGDIHATRRIDREEKAFYTLRAQAINRRTLRPVEPESEFVIKIH 151
Query: 143 DVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAI 202
D+NDN P F ++ ASVPE S VGTSV+ VTA DADDP+ G+ A V+Y IL+G+ YF++
Sbjct: 152 DINDNEPTFPEEIYTASVPEMSVVGTSVVQVTATDADDPSYGNSARVIYSILQGQPYFSV 211
Query: 203 D-NSGRIITITKSLDREKQARYEIVVEARDAQG-LRGDSGTATVLVTLQDINDNFPFFTQ 260
+ +G I T +++RE + +Y++V++A+D G + G SGT TV +TL D+NDN P F Q
Sbjct: 212 EPETGIIRTALPNMNRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQ 271
Query: 261 TKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIK 320
V E + VGT++GS+ D D +N +Y I+ GD D F I T EGII
Sbjct: 272 NTIHLRVLESSPVGTAIGSVKATDADTGKNAEVEYRIIDGDGTDMFDIVTEKDTQEGIIT 331
Query: 321 PMKPLDYEYIQQYSFIVEATDPTIDLR-YMSPPAGNRAQVIINITDVDEPPIFQQPFYHF 379
KPLDYE + Y+ VEA + +D R Y P + V I+I DVDEPP+F + Y F
Sbjct: 332 VKKPLDYESRRLYTLKVEAENTHVDPRFYYLGPFKDTTIVKISIEDVDEPPVFSRSSYLF 391
Query: 380 QLKEN-QKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRV-TKKGDIYNEKELDREV 437
++ E+ + +IGTV+A DPD+ I +S+ R +D + F + + G +Y K LDRE+
Sbjct: 392 EVHEDIEVGTIIGTVMARDPDSISSPIRFSLDRHTDLDRIFNIHSGNGSLYTSKPLDREL 451
Query: 438 YPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLV 497
W+NLTV A E+++ T V V + +LD NDNAP+FA Y VCENA GQL+
Sbjct: 452 SQWHNLTVIAAEINNPKETTR----VAVFVRILDVNDNAPQFAVFYDTFVCENARPGQLI 507
Query: 498 LQISAIDKDITPRNVKFKFILNTEN-NFTLTDNHDNTANITVKYGQFDREHTKVHFLPVV 556
ISA+DKD KF F L N NFT+ DN DNTA I + F+R + LPVV
Sbjct: 508 QTISAVDKDDPLGGQKFFFSLAAVNPNFTVQDNEDNTARILTRKNGFNRHEISTYLLPVV 567
Query: 557 ISDNGMPSRTGTSTLTVAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVI 614
ISDN P ++ T TLT+ VC C+ QG C E + G+S A++AILLCI+ + VI
Sbjct: 568 ISDNDYPIQSSTGTLTIRVCACDSQGNMQSCSAEALLLPAGLSTGALIAILLCIIILLVI 627
Query: 615 TLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPP 674
+L +R RK+ S +I + +V+Y++EGGGE DT ++D+ L + K
Sbjct: 628 VVLFAALKRQRKKEPLI-LSKEDIRDNIVSYNDEGGGEEDTQAFDIGTLRNPAAIEEK-- 684
Query: 675 RPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYE 734
R + + PR P A ++ I + E D D PPYD+L Y YE
Sbjct: 685 ----KLRRDIIPETLFIPRRTPTAPDNT-DVRDFINERLKEHDLDPTAPPYDSLATYAYE 739
Query: 735 GSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 775
G++SIAESLSSL + +++ D +YD+L +WGPRF LAE+YG
Sbjct: 740 GNDSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEMYG 780
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 530 bits (1365), Expect = e-150
Identities = 308/749 (41%), Positives = 450/749 (60%), Gaps = 33/749 (4%)
Query: 44 RQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAETGD 101
R KR W+WNQ + EE S +VGK+ S R + KY+L G+ G +F ++ TGD
Sbjct: 50 RSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGD 109
Query: 102 VFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVP 161
+ A +RLDRE Y L A +++ TG +E S F IK+HD+NDN P+FT ++ A+VP
Sbjct: 110 IQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVP 169
Query: 162 ESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDN-SGRIITITKSLDREKQ 220
E S VGT V+ VTA DADDPT G+ A V+Y IL+G+ YF++++ +G I T ++DRE +
Sbjct: 170 EMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENR 229
Query: 221 ARYEIVVEARDAQG-LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGS 279
+Y++V++A+D G + G SGT TV +TL D+NDN P F Q+ Y F PE + GT +G
Sbjct: 230 EQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGR 289
Query: 280 LFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEA 339
+ D D +N +YSI G+ D F + T+ EGII K LD+E + Y+ VEA
Sbjct: 290 IKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEA 349
Query: 340 TDPTIDLRYM-SPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKEN-QKKPLIGTVLAMD 397
++P ++ R++ P + A V I + DVDEPP+F + Y Q++E+ Q IG+V A D
Sbjct: 350 SNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQD 409
Query: 398 PDAARHSIGYSIRRTSDKGQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTP 456
PDAAR+ + YS+ R +D + F + + G I+ K LDRE W+N+TV A E+++
Sbjct: 410 PDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINN---- 465
Query: 457 TGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKF 516
+ S V ++I+VLD NDNAPEFA+ Y+ VCE A QL+ + A+DKD +F F
Sbjct: 466 PKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSF 525
Query: 517 ILNTE----NNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLT 572
L E +NFT+ DN DNTA I + ++R + LPVVISDN P ++ T T+T
Sbjct: 526 SLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVT 585
Query: 573 VAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVITLLIF--LRRRLRKQA 628
V VC C+ G C E + G+S A+VAILLCI+ I ++T+++F LRR+ +K+
Sbjct: 586 VRVCACDHHGNMQSCHAEALIHPTGLSTGALVAILLCIV-ILLVTVVLFAALRRQRKKEP 644
Query: 629 RAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALD--ARPSLYA 686
K +I + +V+Y++EGGGE DT ++D+ L + P D R +
Sbjct: 645 LIISKE--DIRDNIVSYNDEGGGEEDTQAFDIGTLRN--------PEAIEDNKLRRDIVP 694
Query: 687 QVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSL 746
+ PR P A ++ I + E D D PPYD+L Y YEG+ S+A+SLSSL
Sbjct: 695 EALFLPRRTPTARDNT-DVRDFINQRLKENDTDPTAPPYDSLATYAYEGTGSVADSLSSL 753
Query: 747 GTDSSDSDVDYDFLNDWGPRFKMLAELYG 775
+ ++D+D DYD+L+DWGPRFK LA++YG
Sbjct: 754 ESVTTDADQDYDYLSDWGPRFKKLADMYG 782
>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
Length = 799
Score = 527 bits (1357), Expect = e-149
Identities = 308/744 (41%), Positives = 438/744 (58%), Gaps = 24/744 (3%)
Query: 44 RQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVS--RKNAKYLLKGEYVGKVFRVDAETGD 101
R KR W+WNQM + EE + P VG++ + + K KY+L G+ G +F+++ TGD
Sbjct: 58 RSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGD 117
Query: 102 VFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVP 161
+ AI+RLDRE +EY LTA VD +T + LE PS F IKV D+NDN P F + ++A+VP
Sbjct: 118 IHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVP 177
Query: 162 ESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRII-TITKSLDREKQ 220
E S +GTSV +VTA DADDP G+ A ++Y IL+G+ YF+I+ II T ++DRE +
Sbjct: 178 EMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAK 237
Query: 221 ARYEIVVEARDAQGLRGD-SGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGS 279
Y +V++A+D G G SGT T+ VTL D+NDN P F Q+ Y F VPED +GT++G
Sbjct: 238 EEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGR 297
Query: 280 LFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEA 339
+ D D +N + Y I+ GD F I ++ +GII+ KPLD+E + Y+ VEA
Sbjct: 298 VKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEA 357
Query: 340 TDPTIDLRYMS-PPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQK-KPLIGTVLAMD 397
+ ID R+ P + A V I + D DEPP+F P Y ++ EN +IG V A D
Sbjct: 358 ANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARD 417
Query: 398 PDAARHSIGYSIRRTSDKGQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTP 456
PD I +SI R +D + F + G I LDRE+ W+N+T+ A E+ +
Sbjct: 418 PDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRN---- 473
Query: 457 TGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKF 516
+ S V V I+VLD NDNAPEFA Y+ +CEN GQ++ +SA+DKD F +
Sbjct: 474 HSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLY 533
Query: 517 ILNTE----NNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLT 572
L E NFT+ N DN+ +I K+ F+R+ +V+ LP++ISD+G P + TSTLT
Sbjct: 534 SLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLT 593
Query: 573 VAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARA 630
+ VC C+ G C E +G+S+ A++AIL CI+ + VI +L F+ R K
Sbjct: 594 IRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVL-FVTLRRHKNEPL 652
Query: 631 HGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQK 690
K ++ E ++ YD+EGGGE DT ++D++ L + G P D +P L Q
Sbjct: 653 IIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQN--PDGINGFLPRKDIKPDL----QF 706
Query: 691 PPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDS 750
PR ++ I V+ EAD+D PPYD++ IYGYEG S+A SLSSL + +
Sbjct: 707 MPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTT 766
Query: 751 SDSDVDYDFLNDWGPRFKMLAELY 774
SDSD ++D+L+DWGPRFK L ELY
Sbjct: 767 SDSDQNFDYLSDWGPRFKRLGELY 790
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 513 bits (1321), Expect = e-145
Identities = 308/754 (40%), Positives = 434/754 (57%), Gaps = 26/754 (3%)
Query: 44 RQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAETGD 101
R KR W+WNQ + EE S P +VGK+ S V + + KY+L GE +F +D TGD
Sbjct: 44 RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGD 103
Query: 102 VFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVP 161
+ A +RLDRE + Y L A +D+ T + +E S F IK+ D+NDN P F + A VP
Sbjct: 104 IHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVP 163
Query: 162 ESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDREKQ 220
E S VGTSV+ VTA DADDPT G+ A V+Y IL+G+ YF+++ +G I T ++DRE +
Sbjct: 164 EMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAK 223
Query: 221 ARYEIVVEARDAQGLRGD-SGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGS 279
+Y +V++A+D G G SGT +V VTL D+NDN P F + Y + VPE V + V
Sbjct: 224 DQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVAR 283
Query: 280 LFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEA 339
+ D D N +Y I+ GD F I + EGII K LD+E Y+ +EA
Sbjct: 284 IKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEA 343
Query: 340 TDPTIDLRYMS-PPAGNRAQVIINITDVDEPPIFQQPFYHFQLKE-NQKKPLIGTVLAMD 397
+ D R++S P + V I + DVDEPP+F P Y ++ E Q +IGTV A D
Sbjct: 344 ANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHD 403
Query: 398 PDAARHSIGYSIRRTSDKGQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTP 456
PD++ + YSI R +D ++F + G I K LDRE +N+TV A E +
Sbjct: 404 PDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAME-SQNPSQ 462
Query: 457 TGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKF 516
G+ V I +LD NDNAPEFA Y+ VCENA GQ++ +ISA+DKD +F F
Sbjct: 463 VGRG---YVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYF 519
Query: 517 ILNTE----NNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLT 572
L T+ +NF+L DN DNTA+I + F R+ V++LP+ I D+G PS + T+TLT
Sbjct: 520 SLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLT 579
Query: 573 VAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARA 630
+ VC C+ G C E G+S A++AIL C+LT+ V+ LLI RR +K+
Sbjct: 580 IRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLI 639
Query: 631 HGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQK 690
+ +I E +V YD+EGGGE DT ++D++ L ++ + + D P ++Q
Sbjct: 640 FDEE-RDIRENIVRYDDEGGGEEDTEAFDMAALRNL--NVIRDTKTRRDVTP----EIQF 692
Query: 691 PPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDS 750
R A + I + EAD D PPYD+L Y +EG+ S+AESLSSL + S
Sbjct: 693 LSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSIS 752
Query: 751 SDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY 784
S+SD +YD+L+DWGPRFK LA++YG+ +E LY
Sbjct: 753 SNSDQNYDYLSDWGPRFKRLADMYGTG--QESLY 784
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 513 bits (1321), Expect = e-145
Identities = 308/754 (40%), Positives = 434/754 (57%), Gaps = 26/754 (3%)
Query: 44 RQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAETGD 101
R KR W+WNQ + EE S P +VGK+ S V + + KY+L GE +F +D TGD
Sbjct: 44 RTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTGD 103
Query: 102 VFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVP 161
+ A +RLDRE + Y L A +D+ T + +E S F IK+ D+NDN P F + A VP
Sbjct: 104 IHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGVP 163
Query: 162 ESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDREKQ 220
E S VGTSV+ VTA DADDPT G+ A V+Y IL+G+ YF+++ +G I T ++DRE +
Sbjct: 164 EMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREAK 223
Query: 221 ARYEIVVEARDAQGLRGD-SGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGS 279
+Y +V++A+D G G SGT +V VTL D+NDN P F + Y + VPE V + V
Sbjct: 224 DQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVAR 283
Query: 280 LFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEA 339
+ D D N +Y I+ GD F I + EGII K LD+E Y+ +EA
Sbjct: 284 IKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIEA 343
Query: 340 TDPTIDLRYMS-PPAGNRAQVIINITDVDEPPIFQQPFYHFQLKE-NQKKPLIGTVLAMD 397
+ D R++S P + V I + DVDEPP+F P Y ++ E Q +IGTV A D
Sbjct: 344 ANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAHD 403
Query: 398 PDAARHSIGYSIRRTSDKGQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTP 456
PD++ + YSI R +D ++F + G I K LDRE +N+TV A E +
Sbjct: 404 PDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAME-SQNPSQ 462
Query: 457 TGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKF 516
G+ V I +LD NDNAPEFA Y+ VCENA GQ++ +ISA+DKD +F F
Sbjct: 463 VGRG---YVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYF 519
Query: 517 ILNTE----NNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLT 572
L T+ +NF+L DN DNTA+I + F R+ V++LP+ I D+G PS + T+TLT
Sbjct: 520 SLTTDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLT 579
Query: 573 VAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARA 630
+ VC C+ G C E G+S A++AIL C+LT+ V+ LLI RR +K+
Sbjct: 580 IRVCDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLI 639
Query: 631 HGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQK 690
+ +I E +V YD+EGGGE DT ++D++ L ++ + + D P ++Q
Sbjct: 640 FDEE-RDIRENIVRYDDEGGGEEDTEAFDMAALRNL--NVIRDTKTRRDVTP----EIQF 692
Query: 691 PPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDS 750
R A + I + EAD D PPYD+L Y +EG+ S+AESLSSL + S
Sbjct: 693 LSRPAFKSIPDNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSIS 752
Query: 751 SDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY 784
S+SD +YD+L+DWGPRFK LA++YG+ +E LY
Sbjct: 753 SNSDQNYDYLSDWGPRFKRLADMYGTG--QESLY 784
>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
Length = 781
Score = 509 bits (1310), Expect = e-144
Identities = 312/789 (39%), Positives = 448/789 (56%), Gaps = 34/789 (4%)
Query: 3 RLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNT 62
RL++ C+G LA A A AG+ P R +R W+WNQ + EE
Sbjct: 6 RLLLAWLGGWGCMGRLAAPARAWAGSREHPG------PALLRTRRSWVWNQFFVIEEYAG 59
Query: 63 SLPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTA 120
P +GK+ S V R KYLL GE G VF +D TG++ + LDRE ++Y L A
Sbjct: 60 PEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLA 119
Query: 121 VIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADD 180
VD+ + LE PS F IKV D+NDN P+F ++A+VPE S VGTSVI VTA DADD
Sbjct: 120 QAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADD 179
Query: 181 PTVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDREKQARYEIVVEARDAQG-LRGD 238
P+ G+ A ++Y +L G +F++D +G + T ++DRE Q + +V++A+D G + G
Sbjct: 180 PSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGL 239
Query: 239 SGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSIL 298
SG+ TV VTL D+NDN P F Q+ Y F V E GT VG L +DPD N + YSIL
Sbjct: 240 SGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSIL 299
Query: 299 RGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYM-SPPAGNRA 357
G+ +AF+I T+ +G++ KPLD+E + YSF VEAT+ ID Y+ P + A
Sbjct: 300 DGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVA 359
Query: 358 QVIINITDVDEPPIFQQPFYHFQLKENQKK-PLIGTVLAMDPDAARHSIGYSIRRTSDKG 416
V + + D EPP F Q YH + EN+ L+G + A D D+ I YSI SD
Sbjct: 360 SVRVAVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPE 419
Query: 417 QFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDN 475
+ F + ++G I+ LDRE W+NLTV A ELDS + + S VQV I+ LDENDN
Sbjct: 420 RCFSIQPEEGTIHTAAPLDREARAWHNLTVLATELDS----SAQASRVQVAIQTLDENDN 475
Query: 476 APEFAKPYQPKVCENAVHGQLVLQISAIDKDI--TPRNVKFKFILNTENNFTLTDNHDNT 533
AP+ A+PY VC++A GQL+ I A+D+D +V F+ L + NFT+ DN D +
Sbjct: 476 APQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSHVSFQGPLGPDANFTVQDNRDGS 535
Query: 534 ANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFC--EDMA 591
A++ + H + +P+ + D G P+ + T+T+TV+VC+C G C E
Sbjct: 536 ASLLLPSRPAPPRHAP-YLVPIELWDWGQPALSSTATVTVSVCRCQPDGSVASCWPEAHL 594
Query: 592 AQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGG 651
+ G+S A++AI+ C+ + + +L F+ R +KQ ++ E ++TYD+EGGG
Sbjct: 595 SAAGLSTGALLAIITCVGALLALVVL-FVALRRQKQEALMVLEEEDVRENIITYDDEGGG 653
Query: 652 EMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLY--AQVQKPPRHAPGAHGGPGEMAAMI 709
E DT ++D++ L + GA PP P AR + A+V + PR GP ++A ++
Sbjct: 654 EEDTEAFDITALQN--PDGAAPPAPGPPARRDVLPRARVSRQPRPP-----GPADVAQLL 706
Query: 710 EVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDV--DYDFLNDWGPRF 767
++ EAD D PPYD++ +YGYEG S SLSSLG+ S + L+DWGP F
Sbjct: 707 ALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGAPGPAEPLDDWGPLF 766
Query: 768 KMLAELYGS 776
+ LAELYG+
Sbjct: 767 RTLAELYGA 775
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 499 bits (1284), Expect = e-141
Identities = 298/758 (39%), Positives = 440/758 (58%), Gaps = 45/758 (5%)
Query: 43 RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAETG 100
+R KR W+WNQ + EE S P +VGK+ S + + KY L G+ G VF +D TG
Sbjct: 50 QRVKRGWVWNQFFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTG 109
Query: 101 DVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASV 160
D+ AI LDRE Y L A VD +T + LE S F IKV D+NDN P F + A+V
Sbjct: 110 DIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATV 169
Query: 161 PESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDREK 219
PE S VG V+ V A DADDPT G+ A V+Y IL+G+ YF+ID +G I T ++DRE
Sbjct: 170 PEMSPVGAYVLQVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREV 229
Query: 220 QARYEIVVEARDAQG-LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVG 278
+ +Y+++++A+D G L G +GT V +TL D+NDN P F ++ + VPE + +G+++G
Sbjct: 230 KEQYQVLIQAKDMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIG 289
Query: 279 SLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVE 338
+ DPD QN +Y+I+ GD + F I T+ EG+IK KPLD+E + Y+F VE
Sbjct: 290 RIRAVDPDFGQNAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVE 349
Query: 339 ATDPTIDLRYMSP-PAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQK-KPLIGTVLAM 396
A++ +D R+ S P + A V I++ DVDEPP+F +P Y ++ E+ +IG V A
Sbjct: 350 ASNLHLDHRFHSAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQ 409
Query: 397 DPDAARHSIGYSIRRTSDKGQFFRVT-KKGDIYNEKELDREVYPWYNLTVEAKELDSTGT 455
D D ++ Y I SD +F + +G I + LDRE YN ++ A ++ S
Sbjct: 410 DLDVGSSAVRYFIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKV-SNPL 468
Query: 456 PTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFK 515
T K V + I VLD N+ PE + PY+ VCENA GQ++ +SA D+D++P +F
Sbjct: 469 LTSK---VNILINVLDVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFS 525
Query: 516 FILNTE----NNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTL 571
F L+ E NFT+ D +NTA I + + R +++FLPVVI D+ P ++ T+T+
Sbjct: 526 FRLSPEAAIKPNFTVRDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTM 585
Query: 572 TVAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCI-LTITVITLLIFLRRRLRKQA 628
T+ VC+C+ G C E + VG+S A++AILLCI + + ++ L + LRR+ +K
Sbjct: 586 TIRVCRCDSDGTILSCNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDT 645
Query: 629 RAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVL--------NSVRRGGAKPPRPALDA 680
K +I + ++ YD+EGGGE DT ++D+ L N +RR D
Sbjct: 646 LMTSKE--DIRDNVIHYDDEGGGEEDTQAFDIGALRNPKVIEENKIRR----------DI 693
Query: 681 RP-SLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESI 739
+P SL Q+PP ++ I + E D D PPYD+L Y YEGS S+
Sbjct: 694 KPDSLCLPRQRPPME------DNTDIRDFIHQRLQENDVDPTAPPYDSLATYAYEGSGSV 747
Query: 740 AESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSD 777
AESLSS+ + ++++D DYD+L DWGPRFK+LA+++G +
Sbjct: 748 AESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGEE 785
>gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens]
Length = 819
Score = 494 bits (1272), Expect = e-139
Identities = 312/823 (37%), Positives = 449/823 (54%), Gaps = 64/823 (7%)
Query: 3 RLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNT 62
RL++ C+G LA A A AG+ P R +R W+WNQ + EE
Sbjct: 6 RLLLAWLGGWGCMGRLAAPARAWAGSREHPG------PALLRTRRSWVWNQFFVIEEYAG 59
Query: 63 SLPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTA 120
P +GK+ S V R KYLL GE G VF +D TG++ + LDRE ++Y L A
Sbjct: 60 PEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEATGNIHVTKSLDREEKAQYVLLA 119
Query: 121 VIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADD 180
VD+ + LE PS F IKV D+NDN P+F ++A+VPE S VGTSVI VTA DADD
Sbjct: 120 QAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHATVPEMSNVGTSVIQVTAHDADD 179
Query: 181 PTVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDREKQARYEIVVEARDAQG-LRGD 238
P+ G+ A ++Y +L G +F++D +G + T ++DRE Q + +V++A+D G + G
Sbjct: 180 PSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRETQEEFLVVIQAKDMGGHMGGL 239
Query: 239 SGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSIL 298
SG+ TV VTL D+NDN P F Q+ Y F V E GT VG L +DPD N + YSIL
Sbjct: 240 SGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLVGRLRAQDPDLGDNALMAYSIL 299
Query: 299 RGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYM-SPPAGNRA 357
G+ +AF+I T+ +G++ KPLD+E + YSF VEAT+ ID Y+ P + A
Sbjct: 300 DGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRVEATNTLIDPAYLRRGPFKDVA 359
Query: 358 QVIINITDVDEPPIFQQPFYHFQLKENQKK-PLIGTVLAMDPDAARHSIGYSIRRTSDKG 416
V + + D EPP F Q YH + EN+ L+G + A D D+ I YSI SD
Sbjct: 360 SVRVAVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISAADLDSPASPIRYSILPHSDPE 419
Query: 417 QFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKEL------------------------- 450
+ F + ++G I+ LDRE W+NLTV A EL
Sbjct: 420 RCFSIQPEEGTIHTAAPLDREARAWHNLTVLATELGWSWGPERGWVPLLVAEWSAPAAPP 479
Query: 451 ------DSTGTP---TGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQIS 501
+ G P + + S VQV I+ LDENDNAP+ A+PY VC++A GQL+ I
Sbjct: 480 QRSPVGSAVGIPQDSSAQASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIR 539
Query: 502 AIDKDI--TPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISD 559
A+D+D +V F+ L + NFT+ DN D +A++ + H + +P+ + D
Sbjct: 540 ALDRDEVGNSSHVSFQGPLGPDANFTVQDNRDGSASLLLPSRPAPPRHAP-YLVPIELWD 598
Query: 560 NGMPSRTGTSTLTVAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVITLL 617
G P+ + T+T+TV+VC+C G C E + G+S A++AI+ C+ + + +L
Sbjct: 599 WGQPALSSTATVTVSVCRCQPDGSVASCWPEAHLSAAGLSTGALLAIITCVGALLALVVL 658
Query: 618 IFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPA 677
F+ R +KQ ++ E ++TYD+EGGGE DT ++D++ L + GA PP P
Sbjct: 659 -FVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDTEAFDITALQN--PDGAAPPAPG 715
Query: 678 LDARPSLY--AQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEG 735
AR + A+V + PR GP ++A ++ ++ EAD D PPYD++ +YGYEG
Sbjct: 716 PPARRDVLPRARVSRQPRPP-----GPADVAQLLALRLREADEDPGVPPYDSVQVYGYEG 770
Query: 736 SESIAESLSSLGTDSSDSDV--DYDFLNDWGPRFKMLAELYGS 776
S SLSSLG+ S + L+DWGP F+ LAELYG+
Sbjct: 771 RGSSCGSLSSLGSGSEAGGAPGPAEPLDDWGPLFRTLAELYGA 813
>gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens]
Length = 772
Score = 480 bits (1235), Expect = e-135
Identities = 288/775 (37%), Positives = 430/775 (55%), Gaps = 32/775 (4%)
Query: 15 LGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSS 74
LG+ + A N + + +H R KR W+WNQ + EE NT+ HH+G+++S
Sbjct: 11 LGIPLLWPCLGATENSQTKKVKQPVRSHLRVKRGWVWNQFFVPEEMNTT-SHHIGQLRSD 69
Query: 75 VSRKNA--KYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLE 132
+ N +Y L G G F +D TGD++AI++LDRE S Y L A ++D TG +E
Sbjct: 70 LDNGNNSFQYKLLGAGAGSTFIIDERTGDIYAIQKLDREERSLYILRAQVIDIATGRAVE 129
Query: 133 TPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQ 192
S F IKV D+NDN P F + A VPE S GT VI VTA DADDP+ G++A ++Y
Sbjct: 130 PESEFVIKVSDINDNEPKFLDEPYEAIVPEMSPEGTLVIQVTASDADDPSSGNNARLLYS 189
Query: 193 ILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGD-SGTATVLVTLQDI 251
+L+G+ YF+++ + +I I+ +DRE Q Y ++++A+D G G SGT +VL+ L D+
Sbjct: 190 LLQGQPYFSVEPTTGVIRISSKMDRELQDEYWVIIQAKDMIGQPGALSGTTSVLIKLSDV 249
Query: 252 NDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETN 311
NDN P F ++ Y V E GTS+G++ D D +N YSI D Q F I TN
Sbjct: 250 NDNKPIFKESLYRLTVSESAPTGTSIGTIMAYDNDIGENAEMDYSIEEDDSQ-TFDIITN 308
Query: 312 PAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS-PPAGNRAQVIINITDVDEPP 370
EGI+ K +D+E+ Y + + + + M + + I + DVDEPP
Sbjct: 309 HETQEGIVILKKKVDFEHQNHYGIRAKVKNHHVPEQLMKYHTEASTTFIKIQVEDVDEPP 368
Query: 371 IFQQPFYHFQL-KENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYN 429
+F P+Y F++ +E + +G V A DPD + I YSI R+ + F + G I
Sbjct: 369 LFLLPYYVFEVFEETPQGSFVGVVSATDPDNRKSPIRYSITRS----KVFNINDNGTITT 424
Query: 430 EKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCE 489
LDRE+ WYNL++ A E + + S + ++++VL+ ND+APEF++ Y+ VCE
Sbjct: 425 SNSLDREISAWYNLSITATEKYN----IEQISSIPLYVQVLNINDHAPEFSQYYETYVCE 480
Query: 490 NAVHGQLVLQISAIDKDITPRNVKFKFILNTE----NNFTLTDNHDNTANITVKYGQFDR 545
NA GQ++ ISA+D+D + F F L+ E ++FT+ DN DNTA I F+
Sbjct: 481 NAGSGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFTIIDNQDNTAVILTNRTGFNL 540
Query: 546 EHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVA 603
+ V ++ ++I+DNG+PS T T+TLT+ VC C + G C +++ +G + ++A
Sbjct: 541 QEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIA 600
Query: 604 ILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVL 663
IL+CI+ I L ++ RKQ KS + E + YD+EGGGE DT ++D++ L
Sbjct: 601 ILICIMIIFGFIFLTLGLKQRRKQILFPEKS-EDFRENIFQYDDEGGGEEDTEAFDIAEL 659
Query: 664 NSVRRGGAKPPRPALDAR-PSLYAQ-VQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGD 721
S + R A SLY Q +Q P A I K +EA+ D
Sbjct: 660 RSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSA--------IFRKFILEKLEEANTDPC 711
Query: 722 GPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGS 776
PP+D+L Y +EG+ S+A SLSSL + SD D YD+LN+ GPRFK LA ++GS
Sbjct: 712 APPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLNELGPRFKRLACMFGS 766
>gi|16753221 cadherin 22 precursor [Homo sapiens]
Length = 828
Score = 464 bits (1194), Expect = e-130
Identities = 297/803 (36%), Positives = 422/803 (52%), Gaps = 40/803 (4%)
Query: 4 LMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTS 63
L++LL LG L A + A A++D R KR W+WNQ + EE +
Sbjct: 22 LLLLLPPPPTLLGRLWAAGTPSPSAPGARQDGAL---GAGRVKRGWVWNQFFVVEEYTGT 78
Query: 64 LPHHVGKIKSSVSRKNA--KYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAV 121
P +VGKI S + KY + GE G +F +D TGD+ A+ERLDRE + Y L A
Sbjct: 79 EPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTFYTLRAQ 138
Query: 122 IVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDP 181
D+ T LE S F IKV D+ND+ P F H + SV E S GTSV+ V A DADDP
Sbjct: 139 ARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMASDADDP 198
Query: 182 TVGDHASVMYQILKGKEYFAID-NSGRIITITKSLDREKQARYEIVVEARDAQG-LRGDS 239
T G A ++Y +L G+ +F +D +G I T LDRE Q RYE+V++A D G L G S
Sbjct: 199 TYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAGQLGGLS 258
Query: 240 GTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSIL- 298
G+ TV + + D+NDN P F Q Y F + E +GT+VG + ED D +N Y +
Sbjct: 259 GSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDMTYHLKD 318
Query: 299 -RGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS-PPAGNR 356
D F + T+ E II K LD+E ++ I+EA + +D R+ ++
Sbjct: 319 ESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADLGTFRDQ 378
Query: 357 AQVIINITDVDEPPIFQQPFYHFQLKEN-QKKPLIGTVLAMDPDAARHSIGYSIRRTSDK 415
A V + +TDVDEPP F+ P +++E+ Q L+G V A DPDAA + Y+I R SD
Sbjct: 379 AIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAIDRESDL 438
Query: 416 GQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDEND 474
Q F + G I K LDRE W+N+TV A E D+ + S + I +LD ND
Sbjct: 439 DQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADN----HAQLSRASLRIRILDVND 494
Query: 475 NAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTE----NNFTLTDNH 530
N PE A PY+ VCE+A GQL+ IS +D+D +F F L E +F+L D
Sbjct: 495 NPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLDIQ 554
Query: 531 DNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDM 590
DNTA + ++ F+R+ V FLP+++ D+G P+ + T TLT+ +C C+ G C
Sbjct: 555 DNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCNTT 614
Query: 591 AAQVGVSIQ--AVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEE 648
A + S+ A++A+L+C+L + V+ LLI RR K + + ++ + ++ Y++E
Sbjct: 615 AFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDED-EDMRDNVIKYNDE 673
Query: 649 GGGEMDTTSYDVSVLNSV-----------------RRGGAKPPRPALDARPSLYAQVQKP 691
GGGE DT +YD+S L S+ GG + L ++
Sbjct: 674 GGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERHSL 733
Query: 692 PRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSS 751
P+ P I K AD D PPYD Y +EG++S A SLSSL + SS
Sbjct: 734 PQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGSS 793
Query: 752 DSDVDYDFLNDWGPRFKMLAELY 774
S+ D+ +L+ WGPRF+ LA LY
Sbjct: 794 GSEQDFAYLSSWGPRFRPLAALY 816
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 354 bits (908), Expect = 2e-97
Identities = 256/765 (33%), Positives = 400/765 (52%), Gaps = 49/765 (6%)
Query: 43 RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRK-NAKYLLKGEYVGK----VFRVDA 97
+RQKRDW+ +++ E P + +I+S + + +Y + G + +F ++
Sbjct: 155 QRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDKNLSLRYSVTGPGADQPPTGIFIINP 214
Query: 98 ETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFN 157
+G + + LDRE I+ +HL A VD + G +E P I V D+NDN P F H+++N
Sbjct: 215 ISGQLSVTKPLDREQIARFHLRAHAVDIN-GNQVENPIDIVINVIDMNDNRPEFLHQVWN 273
Query: 158 ASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILK------GKEYFAIDN-SGRIIT 210
+VPE S GT V++VTA+DADDP + + Y+I+ F I+N +G IIT
Sbjct: 274 GTVPEGSKPGTYVMTVTAIDADDPNALN-GMLRYRIVSQAPSTPSPNMFTINNETGDIIT 332
Query: 211 ITKSLDREKQARYEIVVEARDAQG--LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVP 268
+ LDREK +Y ++++A D +G G S TAT ++T+ D+NDN P FT + VP
Sbjct: 333 VAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGEVP 392
Query: 269 EDTRVGTSVGSLFVEDPDEPQNRMTK--YSILRGDYQDAFTIETNPAHNEGIIKPMKPLD 326
E+ RV V +L V D D+P Y I GD F I+T+P N+G++ +KP+D
Sbjct: 393 EN-RVDIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKPID 451
Query: 327 YEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQ-QPFYHFQLKENQ 385
+E + + V A + + + P + A V + + DV+E P F P Q +
Sbjct: 452 FETNRMFVLTVAAENQVPLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQEEGLH 511
Query: 386 KKPLIGTVLAMDPDA-ARHSIGYSIRRTSDKGQFFRVTK-KGDIYNEKELDREVYPWYNL 443
++ T A DPD + +I Y+ + SD + ++ G I LDRE N
Sbjct: 512 AGTMLTTFTAQDPDRYMQQNIRYT--KLSDPANWLKIDPVNGQITTIAVLDRESPNVKNN 569
Query: 444 TVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAI 503
A L S + I +LD NDNAP+ P + + CE + I+A+
Sbjct: 570 IYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVL-PQEAETCETPDPNSI--NITAL 626
Query: 504 DKDITPRNVKFKFIL-----NTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVIS 558
D DI P F F L + N+T+T + + A + +K + ++ +P++I+
Sbjct: 627 DYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLKIKFLE---AGIYEVPIIIT 683
Query: 559 DNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLL- 617
D+G P ++ S L V VC+C+ G+ T D G+ A++AILLCI+ + ++ L+
Sbjct: 684 DSGNPPKSNISILRVKVCQCDSNGDCTDV-DRIVGAGLGTGAIIAILLCIIILLILVLMF 742
Query: 618 -IFLRRRLRKQARAHGKSVPE--IHEQLVTYDEEGGGEMDTTSYDVSVL---NSVRRGGA 671
++++RR +++ PE + + ++ YDEEGGGE D YD+S L ++V
Sbjct: 743 VVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQ-DYDLSQLQQPDTVEPDAI 801
Query: 672 KPPR-PALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHI 730
KP +D RP ++A+ Q P R A H PG++ I AD+D PPYD+L +
Sbjct: 802 KPVGIRRMDERP-IHAEPQYPVRSA-APH--PGDIGDFINEGLKAADNDPTAPPYDSLLV 857
Query: 731 YGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 775
+ YEGS S A SLSSL + SS + DYD+LNDWGPRFK LA++YG
Sbjct: 858 FDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYG 902
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 350 bits (897), Expect = 4e-96
Identities = 264/796 (33%), Positives = 411/796 (51%), Gaps = 66/796 (8%)
Query: 23 VAAAGANPAQRDTHSLLPTH------RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVS 76
V A +P +DT P H RR+KRDW+ +++ E P + +I+S
Sbjct: 139 VVALDPSPPPKDTLLPWPQHQNANGLRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKD 198
Query: 77 RK-NAKYLLKGEYVG------KVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGE 129
+Y + G VG +VF +D+ +G ++ +DRE + YHL A VD + G
Sbjct: 199 NDIPIRYSITG--VGADQPPMEVFSIDSMSGRMYVTRPMDREEHASYHLRAHAVDMN-GN 255
Query: 130 NLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASV 189
+E P I V D+NDN P F ++++N SV E S GT V++VTA DADD T + V
Sbjct: 256 KVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTYVMTVTANDADDSTTA-NGMV 314
Query: 190 MYQIL------KGKEYFAIDN-SGRIITITKSLDREKQARYEIVVEARDAQG--LRGDSG 240
Y+I+ + F I++ +G I+T+ LDREK +Y ++V+A D +G G S
Sbjct: 315 RYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSN 374
Query: 241 TATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQ--NRMTKYSIL 298
TAT ++T+ D+NDN P FT + + VPE+ RV T V +L V D D+P N Y I+
Sbjct: 375 TATAIITVTDVNDNPPEFTASTFAGEVPEN-RVETVVANLTVMDRDQPHSPNWNAVYRII 433
Query: 299 RGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQ 358
GD F++ T+P NEG++ +K +DYE + + V ++ + + A
Sbjct: 434 SGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQSTAG 493
Query: 359 VIINITDVDEPPIFQQPFYHFQLKEN-QKKPLIGTVLAMDPDA-ARHSIGYSIRRTSDKG 416
V I+I D++E P F +L+E ++ T A+DPD + ++ YS + SD
Sbjct: 494 VTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYS--KLSDPA 551
Query: 417 QFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKEL--DSTGTPTGKESIVQVHIEVLDEN 473
+ + G I LDRE N EA L D+ P +Q+++ +D N
Sbjct: 552 SWLHINATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYL--IDIN 609
Query: 474 DNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFIL-----NTENNFTLTD 528
DNAPE P + ++CE + I+A D D+ P + F L N+T+T
Sbjct: 610 DNAPELL-PKEAQICEKP--NLNAINITAADADVDPNIGPYVFELPFVPAAVRKNWTITR 666
Query: 529 NHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCE 588
+ + A ++++ + ++ +P++++D+G P + TS + V VC C++ G+ T
Sbjct: 667 LNGDYAQLSLRILYLE---AGMYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIG 723
Query: 589 DMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSV-----PEIHEQLV 643
+AA G+ A+VAIL+CIL + + LL + + R++ R H K + ++ + ++
Sbjct: 724 AVAA-AGLGTGAIVAILICILILLTMVLLFVMWMKRREKER-HTKQLLIDPEDDVRDNIL 781
Query: 644 TYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRP----ALDARPSLYAQVQKPPRHAPGAH 699
YDEEGGGE D YD+S L G P + +D RP + A+ Q P R
Sbjct: 782 KYDEEGGGEED-QDYDLSQLQQPEAMGHVPSKAPGVRRVDERP-VGAEPQYPIRPMV--- 836
Query: 700 GGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDF 759
PG++ I AD+D PPYD+L ++ YEGS S A S+SSL + SS D DYD+
Sbjct: 837 PHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGSVSSLNS-SSSGDQDYDY 895
Query: 760 LNDWGPRFKMLAELYG 775
LNDWGPRFK LA++YG
Sbjct: 896 LNDWGPRFKKLADMYG 911
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 328 bits (842), Expect = 9e-90
Identities = 262/799 (32%), Positives = 387/799 (48%), Gaps = 64/799 (8%)
Query: 15 LGLLAVAAVAAAGANPAQRDTHSLLPTHR-----RQKRDWIWNQMHIDEEKNTSLPHHVG 69
LGLLA + + G P R +L P R R +R W+ + + E + LP+ +
Sbjct: 9 LGLLAQSLCLSLGV-PGWRRPTTLYPWRRAPALSRVRRAWVIPPISVSEN-HKRLPYPLV 66
Query: 70 KIKSSVSRKNAK-YLLKGEYVGK----VFRVDAETGDVFAIERLDRENISEYHLTAVIVD 124
+IKS + + Y ++G V + VF +D TG VF LDRE + L A +D
Sbjct: 67 QIKSDKQQLGSVIYSIQGPGVDEEPRGVFSIDKFTGKVFLNAMLDREKTDRFRLRAFALD 126
Query: 125 KDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVG 184
G LE P+ I V D NDN P F F V E + GT V A DADDP
Sbjct: 127 LG-GSTLEDPTDLEIVVVDQNDNRPAFLQEAFTGRVLEGAVPGTYVTRAEATDADDPET- 184
Query: 185 DHASVMYQILK--GKEYFAIDN-SGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGT 241
D+A++ + IL+ E F+ID +G I T+ LDRE A Y + ++ D G G + T
Sbjct: 185 DNAALRFSILQQGSPELFSIDELTGEIRTVQVGLDREVVAVYNLTLQVADMSG-DGLTAT 243
Query: 242 ATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEP--QNRMTKYSILR 299
A+ ++TL DINDN P FT+ ++ F+ + G VG L VED D P N + +++IL
Sbjct: 244 ASAIITLDDINDNAPEFTRDEF-FMEAIEAVSGVDVGRLEVEDRDLPGSPNWVARFTILE 302
Query: 300 GDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQV 359
GD FTI T+P NEG++ +K LDYE + Y V + +A+V
Sbjct: 303 GDPDGQFTIRTDPKTNEGVLSIVKALDYESCEHYELKVSVQNEAPLQAAALRAERGQAKV 362
Query: 360 IINITDVDEPPIFQQPFYHFQLKENQKK-PLIGTVLAMDPDAAR-HSIGYSIRRTSDKGQ 417
+++ D +EPP+FQ+ L E L+ T A DPD + + YS + D
Sbjct: 363 RVHVQDTNEPPVFQENPLRTSLAEGAPPGTLVATFSARDPDTEQLQRLSYS--KDYDPED 420
Query: 418 FFRVTKKGDIYNEKELDREVYP-----WYNLTVEAKE-LDSTGTPTGKESIVQVHIEVLD 471
+ +V + + P WY V A++ T TG SI E+L+
Sbjct: 421 WLQVDAATGRIQTQHVLSPASPFLKGGWYRAIVLAQDDASQPRTATGTLSI-----EILE 475
Query: 472 ENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTE-----NNFTL 526
ND+AP A P +C G +L + A D+D+ P F F L+ N++L
Sbjct: 476 VNDHAPVLAPPPPGSLCSEPHQGPGLL-LGATDEDLPPHGAPFHFQLSPRLPELGRNWSL 534
Query: 527 TDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFT- 585
+ + + A + ++ + +H L +++ D+G P + L V VC+C + G
Sbjct: 535 SQVNVSHARLRPRH----QVPEGLHRLSLLLRDSGQPPQQREQPLNVTVCRCGKDGVCLP 590
Query: 586 -FCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGK---SVPEIHEQ 641
+A G+S+ A+V +L L + V+ LL+ LR R KQ+R G ++ +
Sbjct: 591 GAAALLAGGTGLSLGALVIVLASALLLLVLVLLVALRARFWKQSRGKGLLHGPQDDLRDN 650
Query: 642 LVTYDEEGGGEMDTTSYDVSVLN-----SVRRGGAKPPRPALDARPSLYAQVQKPPRHAP 696
++ YDE+GGGE D +YD+S L S+ G R A R L+ Q PPR P
Sbjct: 651 VLNYDEQGGGEEDQDAYDISQLRHPTALSLPLGPPPLRRDAPQGR--LHPQ---PPRVLP 705
Query: 697 GAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVD 756
+ P ++A I + AD D PPYDT IY YEG S+A +LSS+ + D D D
Sbjct: 706 TS---PLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDGSVAGTLSSILSSQGDEDQD 762
Query: 757 YDFLNDWGPRFKMLAELYG 775
YD+L DWGPRF LA++YG
Sbjct: 763 YDYLRDWGPRFARLADMYG 781
>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
Length = 882
Score = 306 bits (785), Expect = 4e-83
Identities = 261/773 (33%), Positives = 376/773 (48%), Gaps = 79/773 (10%)
Query: 40 PTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAK-YLLKGEYVGK----VFR 94
P RRQKRDW+ + E + P ++ +IKS+ ++ Y + G+ VF
Sbjct: 147 PGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFI 206
Query: 95 VDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHR 154
++ ETG + E LDRE I+ Y L + V + G +E P I V D NDN P FT
Sbjct: 207 IERETGWLKVTEPLDRERIATYTLFSHAVSSN-GNAVEDPMEILITVTDQNDNKPEFTQE 265
Query: 155 LFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILK------GKEYFAID-NSGR 207
+F SV E + GTSV+ VTA DADD +A++ Y IL K F I+ N+G
Sbjct: 266 VFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGV 325
Query: 208 IITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVV 267
I +T LDRE Y +VV+A D QG G S TAT ++T+ D NDN P F T Y V
Sbjct: 326 ISVVTTGLDRESFPTYTLVVQAADLQG-EGLSTTATAVITVTDTNDNPPIFNPTTYKGQV 384
Query: 268 PEDTRVGTSVGSLFVEDPDEPQNRMTK--YSILRGDYQDAFTIETNPAHNEGIIKPMKPL 325
PE+ + +L V D D P + Y+IL D F + TNP +N+GI+K K L
Sbjct: 385 PEN-EANVVITTLKVTDADAPNTPAWEAVYTILNDD-GGQFVVTTNPVNNDGILKTAKGL 442
Query: 326 DYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKEN- 384
D+E QQY V T+ + + + A V +++ DV+E PIF P ++ E+
Sbjct: 443 DFEAKQQYILHVAVTNV---VPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDF 499
Query: 385 QKKPLIGTVLAMDPDA-ARHSIGYSIRRTSDKGQFFRVTKK-GDIYNEKELDREVYPWYN 442
I + A +PD I Y I R D + + G I ELDRE +
Sbjct: 500 GVGQEITSYTAQEPDTFMEQKITYRIWR--DTANWLEINPDTGAISTRAELDREDFEHVK 557
Query: 443 LTVEAKELDST--GTP--TGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVL 498
+ + +T G+P TG +++ + + D NDNAP +P CE Q+
Sbjct: 558 NSTYTALIIATDNGSPVATGTGTLLLI---LSDVNDNAP-IPEPRTIFFCERNPKPQV-- 611
Query: 499 QISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKV-------- 550
I+ ID D+ P + FT H +AN T++Y +E +
Sbjct: 612 -INIIDADLPPNT----------SPFTAELTHGASANWTIQYNDPTQESIILKPKMALEV 660
Query: 551 --HFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCED-MAAQVGVSIQAVVAIL-- 605
+ + + + DN ++ +TL V+VC C +G C + G+ I A++ IL
Sbjct: 661 GDYKINLKLMDN--QNKDQVTTLEVSVCDC--EGAAGVCRKAQPVEAGLQIPAILGILGG 716
Query: 606 LCILTITVITLLIFLRRRLRKQARAHGKSVP---EIHEQLVTYDEEGGGEMDTTSYDVSV 662
+ L I ++ LL+FLRRR A +P + + + YDEEGGGE D +D+S
Sbjct: 717 ILALLILILLLLLFLRRR----AVVKEPLLPPEDDTRDNVYYYDEEGGGEEDQ-DFDLSQ 771
Query: 663 LNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDG 722
L+ R A+P D P+L + + PR A P E+ I+ AD D
Sbjct: 772 LH--RGLDARPEVTRNDVAPTLMSVPRYLPRPA-----NPDEIGNFIDENLKAADTDPTA 824
Query: 723 PPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 775
PPYD+L ++ YEGS S A SLSSL + SD D DYD+LN+WG RFK LA++YG
Sbjct: 825 PPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLADMYG 877
>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
Length = 829
Score = 284 bits (726), Expect = 3e-76
Identities = 238/762 (31%), Positives = 365/762 (47%), Gaps = 69/762 (9%)
Query: 43 RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAK-YLLKGEYVGK----VFRVDA 97
RR KRDW+ + + E P + ++KS+ R Y + G VF V+
Sbjct: 103 RRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTKIFYSITGPGADSPPEGVFAVEK 162
Query: 98 ETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFN 157
ETG + + LDRE I++Y L V ++ G ++E P + +I V D ND+ P FT F
Sbjct: 163 ETGWLLLNKPLDREEIAKYELFGHAVSEN-GASVEDPMNISIIVTDQNDHKPKFTQDTFR 221
Query: 158 ASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE------YFAIDNS-GRIIT 210
SV E GTSV+ VTA D DD + V Y I + F I S G I
Sbjct: 222 GSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRSTGTISV 281
Query: 211 ITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPED 270
I+ LDREK Y + ++A D G G + TA +V + D NDN P F KY VPE+
Sbjct: 282 ISSGLDREKVPEYTLTIQATDMDG-DGSTTTAVAVVEILDANDNAPMFDPQKYEAHVPEN 340
Query: 271 TRVGTSVGSLFVEDPDEPQNRMTK--YSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYE 328
VG V L V D D P + + Y I+ GD D FTI T+P N+GI+ K LD+E
Sbjct: 341 A-VGHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTRKGLDFE 399
Query: 329 YIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKEN--QK 386
Q++ VE T+ + ++ + A +++++ DV+E P+F P +++E
Sbjct: 400 AKNQHTLYVEVTN---EAPFVLKLPTSTATIVVHVEDVNEAPVFVPPSKVVEVQEGIPTG 456
Query: 387 KPLIGTVLAMDPDAARHSIGYSIRRTS--------DKGQFFRVTKKGDIYNEKE--LDRE 436
+P+ A DPD I Y I R D GQ VT G + E E +
Sbjct: 457 EPVC-VYTAEDPDKENQKISYRILRDPAGWLAMDPDSGQ---VTAVGTLDREDEQFVRNN 512
Query: 437 VYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQL 496
+Y L ++ +TGT T + + ++D ND+ P +P Q +C + Q+
Sbjct: 513 IYEVMVLAMDNGSPPTTGTGT-------LLLTLIDVNDHGP-VPEPRQITICNQSPVRQV 564
Query: 497 VLQISAIDKDITPRNVKFKFILNTENNFTLT-DNHDNTANITVKYGQFDREHTKVHFLPV 555
++ DKD++P F+ L +++ T + ++ + + +F ++ T + + +
Sbjct: 565 ---LNITDKDLSPHTSPFQAQLTDDSDIYWTAEVNEEGDTVVLSLKKFLKQDT--YDVHL 619
Query: 556 VISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVIT 615
+SD+G ++ + + VC C+ G C G I V+ +L +L + ++
Sbjct: 620 SLSDHG--NKEQLTVIRATVCDCH--GHVETCP--GPWKGGFILPVLGAVLALLFLLLVL 673
Query: 616 LLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPR 675
LL+ ++R K+ + + + + Y EEGGGE D YD++ L+ RG P
Sbjct: 674 LLLVRKKRKIKEPLLLPED--DTRDNVFYYGEEGGGEEDQ-DYDITQLH---RGLEARPE 727
Query: 676 PAL--DARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGY 733
L D P++ PR A P E+ I A+ D PPYDTL ++ Y
Sbjct: 728 VVLRNDVAPTIIPTPMYRPRPA-----NPDEIGNFIIENLKAANTDPTAPPYDTLLVFDY 782
Query: 734 EGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYG 775
EGS S A SLSSL + +SD D DYD+LN+WG RFK LA++YG
Sbjct: 783 EGSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYG 824
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 219 bits (559), Expect = 6e-57
Identities = 184/569 (32%), Positives = 287/569 (50%), Gaps = 55/569 (9%)
Query: 44 RQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGK----VFRVDAET 99
RQKR + + + I E + P VGK+ S + +K+ L G+ V + +FR++ T
Sbjct: 135 RQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRPERSKFRLTGKGVDQEPKGIFRINENT 194
Query: 100 GDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNAS 159
G V LDRE I+ Y L D + G+ LE P + V D NDN P+F +
Sbjct: 195 GSVSVTRTLDREVIAVYQLFVETTDVN-GKTLEGPVPLEVIVIDQNDNRPIFREGPYIGH 253
Query: 160 VPESSAVGTSVISVTAVDADDPTVGDHASVMYQILK------GKEYFAID-NSGRIITIT 212
V E S GT+V+ +TA DADDP D+A + Y I + F ID G I+T+
Sbjct: 254 VMEGSPTGTTVMRMTAFDADDPAT-DNALLRYNIRQQTPDKPSPNMFYIDPEKGDIVTVV 312
Query: 213 KS--LDRE--KQARYEIVVEARDAQGLR-GDSGTATVLVTLQDINDNFPFFTQTKYTFVV 267
LDRE + +YE+++EA+D GL G +GTAT + + D ND+ P FT+ ++ V
Sbjct: 313 SPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQATV 372
Query: 268 PEDTRVGTSVGSLFVEDPDEPQNRMTK--YSILRGDYQDAFTIETNPAHNEGIIKPMKPL 325
E+ VG V +L VED D+P + Y+I+ G+ +F I TNP NEG++ +KPL
Sbjct: 373 -EEGAVGVIV-NLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKPL 430
Query: 326 DYEYIQQYSFI--VEATDPTI-DLRYMSPPAGNRAQVIINITDVDEPPIF-QQPFYHFQL 381
DYE ++ + VE DP + D+ Y + A V I + DV+E P+F P +
Sbjct: 431 DYEISAFHTLLIKVENEDPLVPDVSY---GPSSTATVHITVLDVNEGPVFYPDPMMVTRQ 487
Query: 382 KENQKKPLIGTVLAMDPDAARH-SIGYSIRRTSDKGQFFRVTK-KGDIYNEKELDRE--- 436
++ ++ TV A DPD+ +H +I YS+ + D + + G + LDRE
Sbjct: 488 EDLSVGSVLLTVNATDPDSLQHQTIRYSVYK--DPAGWLNINPINGTVDTTAVLDRESPF 545
Query: 437 ----VYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAV 492
VY L +++ +TGT T + I + D NDNAP F P +VC++A
Sbjct: 546 VDNSVYTALFLAIDSGNPPATGTGT-------LLITLEDVNDNAP-FIYPTVAEVCDDAK 597
Query: 493 HGQLVLQISAIDKDITPRNVKFKFILNTE---NNFTLTDNHDNTANITVKYGQFDREHTK 549
+ +V+ + A DKD+ P FKF ++ + + +NT + ++ +
Sbjct: 598 NLSVVI-LGASDKDLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKAN-- 654
Query: 550 VHFLPVVISDNGMPSRTGTSTLTVAVCKC 578
+ LP++++D+G P T + L V VC C
Sbjct: 655 -YNLPIMVTDSGKPPMTNITDLRVQVCSC 682
Score = 89.4 bits (220), Expect = 1e-17
Identities = 104/412 (25%), Positives = 170/412 (41%), Gaps = 32/412 (7%)
Query: 197 KEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFP 256
K F I+ + +++T++LDRE A Y++ VE D G + G + V + D NDN P
Sbjct: 185 KGIFRINENTGSVSVTRTLDREVIAVYQLFVETTDVNG-KTLEGPVPLEVIVIDQNDNRP 243
Query: 257 FFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEP--QNRMTKYSILRGDYQ----DAFTIET 310
F + Y V E + GT+V + D D+P N + +Y+I + + F I+
Sbjct: 244 IFREGPYIGHVMEGSPTGTTVMRMTAFDADDPATDNALLRYNIRQQTPDKPSPNMFYIDP 303
Query: 311 NPAHNEGIIKPMKPLDYEYIQ--QYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-D 367
++ P LD E ++ +Y I+EA D + + A I I D D
Sbjct: 304 EKGDIVTVVSPAL-LDRETLENPKYELIIEAQD----MAGLDVGLTGTATATIMIDDKND 358
Query: 368 EPPIFQQPFYHFQLKENQKKPLIGTVLAM--DPDAARHSIGYSIRRTSDKGQFFRV---- 421
P F + + ++E ++ + DP Y+I + GQ F +
Sbjct: 359 HSPKFTKKEFQATVEEGAVGVIVNLTVEDKDDPTTGAWRAAYTIIN-GNPGQSFEIHTNP 417
Query: 422 -TKKGDIYNEKELDREVYPWYNLTVEAKELDST--GTPTGKESIVQVHIEVLDENDNAPE 478
T +G + K LD E+ ++ L ++ + D G S VHI VLD N+
Sbjct: 418 QTNEGMLSVVKPLDYEISAFHTLLIKVENEDPLVPDVSYGPSSTATVHITVLDVNEGPVF 477
Query: 479 FAKPYQPKVCENAVHGQLVLQISAIDKDI----TPRNVKFKFILNTENNFTLTDNHDNTA 534
+ P E+ G ++L ++A D D T R +K N + D TA
Sbjct: 478 YPDPMMVTRQEDLSVGSVLLTVNATDPDSLQHQTIRYSVYKDPAGWLNINPINGTVDTTA 537
Query: 535 NITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTF 586
+ + D FL + D+G P TGT TL + + N+ F +
Sbjct: 538 VLDRESPFVDNSVYTALFLAI---DSGNPPATGTGTLLITLEDVNDNAPFIY 586
>gi|29570800 cadherin-like 26 isoform a [Homo sapiens]
Length = 832
Score = 212 bits (539), Expect = 1e-54
Identities = 225/803 (28%), Positives = 353/803 (43%), Gaps = 98/803 (12%)
Query: 43 RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVS-RKNAKYLLKG----EY--VGKVFRV 95
RR KR W+ + ++EE P +G++ +++S + YL+ G EY +G
Sbjct: 50 RRSKRRWVITTLELEEEDPGPFPKLIGELFNNMSYNMSLMYLISGPGVDEYPEIGLFSLE 109
Query: 96 DAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRL 155
D E G ++ +DRE + + +V++ TG+ ++T F I++ DVND+ P F +
Sbjct: 110 DHENGRIYVHRPVDREMTPSFTVYFDVVERSTGKIVDTSLIFNIRISDVNDHAPQFPEKE 169
Query: 156 FNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQI-----LKGKEYFAIDNSGRIIT 210
FN +V E+ + G + + AVD D+ ++ V+Y + L + F +D I
Sbjct: 170 FNITVQENQSAGQPIFQMLAVDLDEENT-PNSQVLYFLISQTPLLKESGFRVDRLSGEIR 228
Query: 211 ITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPED 270
++ LD E ++ +++ ARD G S T TV V +Q+ N++ P FTQ Y +PE
Sbjct: 229 LSGCLDYETAPQFTLLIRARDC-GEPSLSSTTTVHVDVQEGNNHRPAFTQENYKVQIPEG 287
Query: 271 TRVGTSVGSLFVEDPDEPQNR--MTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYE 328
R V L V+D D P K++IL G+ + F I T+P NEGI+ +KPLDYE
Sbjct: 288 -RASQGVLRLLVQDRDSPFTSAWRAKFNILHGNEEGHFDISTDPETNEGILNVIKPLDYE 346
Query: 329 Y--IQQYSFIVEATDPTI--DLRYMSPP--AGNRAQVIINITDVDEPPIFQQPFYHFQLK 382
Q +VE + + + + PP A A V + +TD ++PP F P K
Sbjct: 347 TRPAQSLIIVVENEERLVFCERGKLQPPRKAAASATVSVQVTDANDPPAF-HPQSFIVNK 405
Query: 383 ENQKKP--LIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTK-KGDIYNEKELDREV-- 437
E +P L+GT AMDPD+ I Y + D + V K G + + +DRE
Sbjct: 406 EEGARPGTLLGTFNAMDPDS---QIRYEL--VHDPANWVSVDKNSGVVITVEPIDRESPH 460
Query: 438 --YPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEF-AKPYQPKVCENAVHG 494
+Y + + A +D P + + + D NDN P + +VCE+AVH
Sbjct: 461 VNNSFYVIIIHA--VDDGFPPQTATGTLMLFLS--DINDNVPTLRPRSRYMEVCESAVHE 516
Query: 495 QLVLQISAIDKDITPRNVKFKFIL-----NTENNFTLTDNHDNTANITVKYGQFDREHTK 549
L I A D D+ P + F F L N E+ + L N + + + R +
Sbjct: 517 P--LHIEAEDPDLEPFSDPFTFELDNTWGNAEDTWKLGRNWGQSVEL-LTLRSLPRGN-- 571
Query: 550 VHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCIL 609
+ +P+ I D S+ T+ V +C C T E A+VG+ + A+ + +
Sbjct: 572 -YLVPLFIGDKQGLSQ--KQTVHVRICPC--ASGLTCVELADAEVGLHVGALFPVCAAFV 626
Query: 610 TITVITLLIFLRRRLRKQARAHGKSV--PEIHEQLVTYDEEGGGEMDTTSYDVS------ 661
+ V LL LR + + HG SV E H+ LV Y+ E G T DV
Sbjct: 627 ALAV-ALLFLLRCYFVLEPKRHGCSVSNDEGHQTLVMYNAESKGTSAQTWSDVEGQRPAL 685
Query: 662 VLNSVRRGGAKPPRPALDARPSLYAQ------------VQKP--PRHAPGAHGGP----- 702
++ + G + + + PS +Q KP PR H P
Sbjct: 686 LICTAAAGPTQGVKDLEEVPPSAASQSAQARCALGSWGYGKPFEPRSVKNIHSTPAYPDA 745
Query: 703 -----------GEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSS 751
G MA + K A+ D P Y H+Y EG A SLSSL S
Sbjct: 746 TMHRQLLAPVEGRMAETLNQKLHVANVLEDDPGY-LPHVYSEEGECGGAPSLSSLA--SL 802
Query: 752 DSDVDYDFLNDWGPRFKMLAELY 774
+ ++ D L+ G + E+Y
Sbjct: 803 EQELQPDLLDSLGSKATPFEEIY 825
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 201 bits (511), Expect = 2e-51
Identities = 170/498 (34%), Positives = 235/498 (47%), Gaps = 32/498 (6%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
F +D ETG + + +DRE+ Y L I D + + TI V D NDN PVF
Sbjct: 774 FNIDMETGQLKVLMPMDREHTDLYLLNITIYDLGNPQK-SSWRLLTINVEDANDNSPVFI 832
Query: 153 HRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITIT 212
++ ++ ESS +GT +I V A D D +G + V Y +L + FAI++S I+ +
Sbjct: 833 QDSYSVNILESSGIGTEIIQVEARDKD---LGSNGEVTYSVLTDTQQFAINSSTGIVYVA 889
Query: 213 KSLDREKQARYEIVVEARD-AQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDT 271
LDRE +A Y + +EARD A+ + T+ V L D+ND P F + Y+ V ED
Sbjct: 890 DQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDL 949
Query: 272 RVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQ 331
VGT + L DPD +YS++ DY F I+ G I+ K LDYE Q
Sbjct: 950 PVGTVIAWLETHDPDLGLGGQVRYSLV-NDYNGRFEID----KASGAIRLSKELDYEKQQ 1004
Query: 332 QYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDE---PPIFQQPFYHFQLKENQKKP 388
Y+ V A D + S + V + + DV+E P F +KEN +
Sbjct: 1005 FYNLTVRAKDKGRPVSLSSV-----SFVEVEVVDVNENLHTPYFPDFAVVGSVKENSR-- 1057
Query: 389 LIGT----VLAMDPDAARH-SIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNL 443
IGT V A D D+ R I YSIR S G+F + G I LDRE Y L
Sbjct: 1058 -IGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDESGVITAADILDRETMGSYWL 1116
Query: 444 TVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQISA 502
TV A D P S ++V+IEV D NDNAP ++P Y P V EN+ V+QI A
Sbjct: 1117 TVYA--TDRGVVPL--YSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPKDVSVIQIQA 1172
Query: 503 IDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGM 562
D D + N K + + + N + T IT + DRE HFL V ++D G
Sbjct: 1173 EDPD-SSSNEKLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFLEVTVTDGGP 1231
Query: 563 PSRTGTSTLTVAVCKCNE 580
+ T + V V N+
Sbjct: 1232 SPKQSTIWVVVQVLDEND 1249
Score = 183 bits (465), Expect = 5e-46
Identities = 171/525 (32%), Positives = 243/525 (46%), Gaps = 48/525 (9%)
Query: 70 KIKSSVSRKNA--------KYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAV 121
KI VS K+A +Y L G + F +D E+G++ + LDRE I Y L A
Sbjct: 3046 KIILKVSAKDADIGSNGYIRYSLYGSGNSEFF-LDPESGELKTLALLDRERIPVYSLMAK 3104
Query: 122 IVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDP 181
D G S+ + + DVNDN PVF+ +N V E++A + V AVD P
Sbjct: 3105 ATD---GGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTRVQAVD---P 3158
Query: 182 TVGDHASVMYQILKGKE-YFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSG 240
+G + V+Y + F+ID+S II + + LDRE+Q+ Y I V A D + S
Sbjct: 3159 DIGINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRATDQSPGQSLSS 3218
Query: 241 TATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRG 300
TV +T+ DINDN P F + Y VPEDT GT V ++F D N Y I G
Sbjct: 3219 LTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTNAEITYLIRSG 3278
Query: 301 DYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVI 360
+ Q F I NP G I + LDYE +++ +VEA D +P A V
Sbjct: 3279 NEQGKFKI--NP--KTGGISVSEVLDYELCKRFYLVVEAKDGG------TPALSAVATVN 3328
Query: 361 INITDV-DEPPIFQQPFYHFQLKENQKKPLIG----TVLAMDPDAARH-SIGYSIRRTSD 414
IN+TDV D PP F Q Y + E+ L+G ++A D D+ + I +SI
Sbjct: 3329 INLTDVNDNPPKFSQDVYSAVISED---ALVGDSVILLIAEDVDSQPNGQIHFSIVNGDR 3385
Query: 415 KGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDEND 474
+F G + +K+LDRE Y+L V+A + +G P S V+I++ D ND
Sbjct: 3386 DNEFTVDPVLGLVKVKKKLDRERVSGYSLLVQAVD---SGIP-AMSSTATVNIDISDVND 3441
Query: 475 NAPEFAKP-YQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFIL---NTENNFTLTDNH 530
N+P F Y + EN G +LQ+ D+D F F + N E F L D H
Sbjct: 3442 NSPVFTPANYTAVIQENKPVGTSILQLVVTDRDSFHNGPPFSFSILSGNEEEEFVL-DPH 3500
Query: 531 DNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAV 575
+ V F + + L V D+G P + + + V V
Sbjct: 3501 GILRSAVV----FQHTESLEYVLCVQAKDSGKPQQVSHTYIRVRV 3541
Score = 159 bits (402), Expect = 9e-39
Identities = 145/498 (29%), Positives = 230/498 (46%), Gaps = 44/498 (8%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDK-DTGENLETPSSFTIKVHDVNDNWPVF 151
F +++ TG V+ ++LDRE+ + Y L DK ++G+ L + + + + DVND P F
Sbjct: 877 FAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQLFSVVTLKVFLDDVNDCSPAF 936
Query: 152 THRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE-YFAIDNSGRIIT 210
++ V E VGT + ++ DP +G V Y ++ F ID + I
Sbjct: 937 IPSSYSVKVLEDLPVGTVI---AWLETHDPDLGLGGQVRYSLVNDYNGRFEIDKASGAIR 993
Query: 211 ITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNF--PFFTQTKYTFVVP 268
++K LD EKQ Y + V A+D S + V V + D+N+N P+F V
Sbjct: 994 LSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVVDVNENLHTPYFPDFAVVGSVK 1053
Query: 269 EDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYE 328
E++R+GTSV + D D ++ +YSI G F+I+ G+I LD E
Sbjct: 1054 ENSRIGTSVLQVTARDEDSGRDGEIQYSIRDGSGLGRFSIDDE----SGVITAADILDRE 1109
Query: 329 YIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQLKENQKK 387
+ Y V ATD + P + +V I + DV D P+ +P Y+ + EN K
Sbjct: 1110 TMGSYWLTVYATDRGV------VPLYSTIEVYIEVEDVNDNAPLTSEPIYYPVVMENSPK 1163
Query: 388 PL-IGTVLAMDPDAARHSIGYSIRRTSDKGQ-FFRVTKKGDIYN--EKELDREVYPWYNL 443
+ + + A DPD++ + + R TS Q FF + K + ++LDRE + L
Sbjct: 1164 DVSVIQIQAEDPDSSSNE-KLTYRITSGNPQNFFAINIKTGLITTTSRKLDREQQAEHFL 1222
Query: 444 TVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEF-AKPYQPKVCE--NAVHGQLVLQI 500
V + G P+ K+S + V ++VLDENDN P+F K YQ K+ E G+ + +
Sbjct: 1223 EVTVTD----GGPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPERDRKKRGEPIYRA 1278
Query: 501 SAIDKDITPRNVKFKFILNTENNFTLTD-NHDNTANITVKYGQFDREHT----KVHFLPV 555
A D+D P N E ++++ D N D I K G L +
Sbjct: 1279 FAFDRDEGP---------NAEISYSIVDGNDDGKFFIDPKTGMVSSRKQFTAGSYDILTI 1329
Query: 556 VISDNGMPSRTGTSTLTV 573
DNG P ++ T+ L +
Sbjct: 1330 KAVDNGRPQKSSTARLHI 1347
Score = 156 bits (395), Expect = 6e-38
Identities = 153/534 (28%), Positives = 241/534 (45%), Gaps = 41/534 (7%)
Query: 87 EYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVND 146
E V + F +D+ TG + ++ LD E + + V D +L + + +++V D+ND
Sbjct: 2860 EKVMEAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDIND 2919
Query: 147 NWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQIL----KGKEYFAI 202
N PVF ++ +V ES G V ++ D D V + V Y I +G+ +
Sbjct: 2920 NAPVFAQEVYRGNVKESDPPGEVVAVLSTWDRDTSDV--NRQVSYHITGGNPRGRFALGL 2977
Query: 203 DNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTK 262
S + + + LDRE+Q Y + + A D + A V V++ D+NDN P Q
Sbjct: 2978 VQSEWKVYVKRPLDREEQDIYFLNITATDGLFVT----QAMVEVSVSDVNDNSPVCDQVA 3033
Query: 263 YTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPM 322
YT ++PED + + +D D N +YS L G F ++ G +K +
Sbjct: 3034 YTALLPEDIPSNKIILKVSAKDADIGSNGYIRYS-LYGSGNSEFFLDP----ESGELKTL 3088
Query: 323 KPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNR---AQVIINITDV-DEPPIFQQPFYH 378
LD E I YS + +ATD G R + + + + DV D PP+F Y+
Sbjct: 3089 ALLDRERIPVYSLMAKATD-----------GGGRFCQSNIHLILEDVNDNPPVFSSDHYN 3137
Query: 379 FQLKEN-QKKPLIGTVLAMDPD-AARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDRE 436
+ EN K L+ V A+DPD + YS+ S G F + G I E+ LDRE
Sbjct: 3138 TCVYENTATKALLTRVQAVDPDIGINRKVVYSL-ADSAGGVFSIDSSSGIIILEQPLDRE 3196
Query: 437 VYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEF-AKPYQPKVCENAVHGQ 495
YN++V A + S G S+ V I VLD NDN P F + Y V E+ G
Sbjct: 3197 QQSSYNISVRATD-QSPG--QSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGT 3253
Query: 496 LVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPV 555
VL + A KDI N + +++ + N + T I+V D E K +L V
Sbjct: 3254 QVLAVFATSKDI-GTNAEITYLIRSGNEQGKFKINPKTGGISVS-EVLDYELCKRFYLVV 3311
Query: 556 VISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCIL 609
D G P+ + +T+ + + N+ F +D+ + V +S A+V + +L
Sbjct: 3312 EAKDGGTPALSAVATVNINLTDVNDNPP-KFSQDVYSAV-ISEDALVGDSVILL 3363
Score = 150 bits (378), Expect = 6e-36
Identities = 147/508 (28%), Positives = 232/508 (45%), Gaps = 55/508 (10%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
FR+D TG ++ ERLD E ++ L ++ D++ + + V D ND+ P FT
Sbjct: 1509 FRIDPSTGVLYTAERLDHEAQDKHILNIMVRDQEFPYRRNL-ARVIVNVEDANDHSPYFT 1567
Query: 153 HRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGK--EYFAIDNSGRIIT 210
+ L+ ASV ES+A+G++V+ VTA+D D G++A ++Y I G F I+ IIT
Sbjct: 1568 NPLYEASVFESAALGSAVLQVTALDKDK---GENAELIYTIEAGNTGNMFKIEPVLGIIT 1624
Query: 211 ITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPED 270
I K D ++ + ++ D QG S TA V +++ +++ P F Y V E+
Sbjct: 1625 ICKEPDMTTMGQFVLSIKVTD-QGSPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNEN 1683
Query: 271 TRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYI 330
+GTSV + Y + GD FTI NP G+I K LDYE
Sbjct: 1684 VDIGTSVILI-----SAISQSTLIYEVKDGDINGIFTI--NP--YSGVITTQKALDYERT 1734
Query: 331 QQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDE---PPIFQQPFYHFQLKEN--- 384
Y I++AT+ AG + +NI VDE P+F Y L E
Sbjct: 1735 SSYQLIIQATN----------MAGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPI 1784
Query: 385 -------QKKPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDRE 436
PL+ + A D D+ R++ + Y I ++ K F + G I LD E
Sbjct: 1785 NSIVRSLDNSPLV--IRATDADSNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHE 1842
Query: 437 VYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQ 495
++ V + DS ES V+V+IEV D NDN P F + ++ + G
Sbjct: 1843 TIAHFHFHVHVR--DSGSPQLTAESPVEVNIEVTDVNDNPPVFTQAVFETILLLPTYVGV 1900
Query: 496 LVLQISAIDKDI-TPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLP 554
VL++SA D D P + + + + ++F + N+ +T+K ++H + L
Sbjct: 1901 EVLKVSATDPDSEVPPELTYSLMEGSLDHFLI---DSNSGVLTIKNNNLSKDH---YMLI 1954
Query: 555 VVISDNGMPSRTGTSTLTVAVCKCNEQG 582
V +SD S TS +T+ V + + G
Sbjct: 1955 VKVSDGKFYS---TSMVTIMVKEAMDSG 1979
Score = 150 bits (378), Expect = 6e-36
Identities = 140/487 (28%), Positives = 220/487 (45%), Gaps = 37/487 (7%)
Query: 102 VFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVP 161
V+ LDRE Y L D T + + V DVNDN PV + A +P
Sbjct: 2984 VYVKRPLDREEQDIYFLNITATDG----LFVTQAMVEVSVSDVNDNSPVCDQVAYTALLP 3039
Query: 162 ESSAVGTSVISVTAVDADDPTVGDHASVMYQILKG--KEYFAIDNSGRIITITKSLDREK 219
E ++ V+A DAD +G + + Y + E+F SG + T+ LDRE+
Sbjct: 3040 EDIPSNKIILKVSAKDAD---IGSNGYIRYSLYGSGNSEFFLDPESGELKTLAL-LDRER 3095
Query: 220 QARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGS 279
Y ++ +A D G S + + L+D+NDN P F+ Y V E+T +
Sbjct: 3096 IPVYSLMAKATDGGGRFCQSN---IHLILEDVNDNPPVFSSDHYNTCVYENTATKALLTR 3152
Query: 280 LFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEA 339
+ DPD NR YS L F+I+++ GII +PLD E Y+ V A
Sbjct: 3153 VQAVDPDIGINRKVVYS-LADSAGGVFSIDSS----SGIIILEQPLDREQQSSYNISVRA 3207
Query: 340 TDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQLKENQKKPL-IGTVLAMD 397
TD + + V I + D+ D PP+F++ Y + E+ + V A
Sbjct: 3208 TDQS-----PGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATS 3262
Query: 398 PDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTP 456
D ++ I Y IR +++G+F K G I + LD E+ + L VEAK+ GTP
Sbjct: 3263 KDIGTNAEITYLIRSGNEQGKFKINPKTGGISVSEVLDYELCKRFYLVVEAKD---GGTP 3319
Query: 457 TGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQISAIDKDITPRNVKFK 515
++ V+I + D NDN P+F++ Y + E+A+ G V+ + A D D P
Sbjct: 3320 A-LSAVATVNINLTDVNDNPPKFSQDVYSAVISEDALVGDSVILLIAEDVDSQPNGQIHF 3378
Query: 516 FILN--TENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTV 573
I+N +N FT+ D + + DRE + L V D+G+P+ + T+T+ +
Sbjct: 3379 SIVNGDRDNEFTV----DPVLGLVKVKKKLDRERVSGYSLLVQAVDSGIPAMSSTATVNI 3434
Query: 574 AVCKCNE 580
+ N+
Sbjct: 3435 DISDVND 3441
Score = 149 bits (377), Expect = 7e-36
Identities = 140/505 (27%), Positives = 225/505 (44%), Gaps = 43/505 (8%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
F +D E+G + A + LDRE + Y LT D+ T + I+V DVNDN P+ +
Sbjct: 1091 FSIDDESGVITAADILDRETMGSYWLTVYATDRGVVPLYSTIEVY-IEVEDVNDNAPLTS 1149
Query: 153 HRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKG--KEYFAID-NSGRII 209
++ V E+S SVI + A+DP + + Y+I G + +FAI+ +G I
Sbjct: 1150 EPIYYPVVMENSPKDVSVIQI---QAEDPDSSSNEKLTYRITSGNPQNFFAINIKTGLIT 1206
Query: 210 TITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPE 269
T ++ LDRE+QA + + V D G T V+V + D NDN P F + Y +PE
Sbjct: 1207 TTSRKLDREQQAEHFLEVTVTDG-GPSPKQSTIWVVVQVLDENDNKPQFPEKVYQIKLPE 1265
Query: 270 DTRV--GTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDY 327
R G + F D DE N YSI+ G+ F I+ G++ K
Sbjct: 1266 RDRKKRGEPIYRAFAFDRDEGPNAEISYSIVDGNDDGKFFIDPKT----GMVSSRKQFT- 1320
Query: 328 EYIQQYSFI-VEATDPTIDLRYMSPPAGNRAQVIINITDVDEPP------IFQQPFYHFQ 380
Y + ++A D P + A+ ++I + +PP F +PFY+F
Sbjct: 1321 --AGSYDILTIKAVDNG------RPQKSSTAR--LHIEWIKKPPPSPIPLTFDEPFYNFT 1370
Query: 381 LKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPW 440
+ E+ + I V+++ P A + + I + F G I K LD E
Sbjct: 1371 VMESDRVTEIVGVVSVQP--ANTPLWFDIVGGNFDSAFDAEKGVGTIVIAKPLDAEQRSI 1428
Query: 441 YNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQ 499
YN++VE + GT ++ QV I+VLD NDN PEF++P Y + E+ + +LQ
Sbjct: 1429 YNMSVEVTD----GTNV---AVTQVFIKVLDNNDNGPEFSQPNYDVTISEDVLPDTEILQ 1481
Query: 500 ISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISD 559
I A D+D + + + ++ D + + + D E H L +++ D
Sbjct: 1482 IEATDRD-EKHKLSYTVHSSIDSISMRKFRIDPSTGVLYTAERLDHEAQDKHILNIMVRD 1540
Query: 560 NGMPSRTGTSTLTVAVCKCNEQGEF 584
P R + + V V N+ +
Sbjct: 1541 QEFPYRRNLARVIVNVEDANDHSPY 1565
Score = 142 bits (357), Expect = 2e-33
Identities = 153/547 (27%), Positives = 227/547 (41%), Gaps = 42/547 (7%)
Query: 90 GKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWP 149
G +F ++ ETG + +RLDRE +H ++ IKV D+NDN P
Sbjct: 2753 GGIFVIEQETGTIKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKP 2812
Query: 150 VFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMY------QILKGKEYFAID 203
VF ++ + E VGT + V A+D D G + V Y Q K E F ID
Sbjct: 2813 VFETSSYDTIIMEGMPVGTKLTQVRAIDMD---WGANGQVTYSLHSDSQPEKVMEAFNID 2869
Query: 204 NSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKY 263
++ I+ K LD E + V A D S TA V V + DINDN P F Q Y
Sbjct: 2870 SNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDINDNAPVFAQEVY 2929
Query: 264 TFVVPEDTRVGTSVGSLFVEDPDEPQ-NRMTKYSILRGDYQDAFTIETNPAHNEGIIKPM 322
V E G V L D D NR Y I G+ + F + +E +
Sbjct: 2930 RGNVKESDPPGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFAL--GLVQSEWKVYVK 2987
Query: 323 KPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQL 381
+PLD E Y + ATD +A V ++++DV D P+ Q Y L
Sbjct: 2988 RPLDREEQDIYFLNITATDGLF---------VTQAMVEVSVSDVNDNSPVCDQVAYTALL 3038
Query: 382 KEN-QKKPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYP 439
E+ +I V A D D + I YS+ S +FF + G++ LDRE P
Sbjct: 3039 PEDIPSNKIILKVSAKDADIGSNGYIRYSL-YGSGNSEFFLDPESGELKTLALLDRERIP 3097
Query: 440 WYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVL 498
Y+L +A + G+ +H+ + D NDN P F+ Y V EN L+
Sbjct: 3098 VYSLMAKATD------GGGRFCQSNIHLILEDVNDNPPVFSSDHYNTCVYENTATKALLT 3151
Query: 499 QISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVIS 558
++ A+D DI + K + + ++ + D+++ I + DRE + + V +
Sbjct: 3152 RVQAVDPDI---GINRKVVYSLADSAGGVFSIDSSSGIIILEQPLDREQQSSYNISVRAT 3208
Query: 559 DNGM-PSRTGTSTLTVAVCKCN------EQGEFTFCEDMAAQVGVSIQAVVAILLCILTI 611
D S + +T+T+ V N E+ ++ G + AV A I T
Sbjct: 3209 DQSPGQSLSSLTTVTITVLDINDNPPVFERRDYLVTVPEDTSPGTQVLAVFATSKDIGTN 3268
Query: 612 TVITLLI 618
IT LI
Sbjct: 3269 AEITYLI 3275
Score = 139 bits (351), Expect = 8e-33
Identities = 128/462 (27%), Positives = 203/462 (43%), Gaps = 39/462 (8%)
Query: 54 MHIDEEKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENI 113
+ +D E T + K Y+L+ +Y F ++ +G+V E + + +
Sbjct: 2093 VQVDAEPGTLIYQVTAIDKDKGPNGEVTYVLQDDYGH--FEINPNSGNVILKEAFNSD-L 2149
Query: 114 SEYHLTAVIVDKDTGE-NLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVIS 172
S I+ KD G+ +L T I + VN PVF + ASV E + T ++S
Sbjct: 2150 SNIEYGVTILAKDGGKPSLSTSVELPITI--VNKAMPVFDKPFYTASVNEDIRMNTPILS 2207
Query: 173 VTAVDADDPTVGDHASVMYQILKGKEY--FAIDNSGRIITITKSLDREKQARYEIVVEAR 230
+ A T + ++Y I+ G + F ID ++ + LD E + Y++ + A
Sbjct: 2208 INA------TSPEGQGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIRAS 2261
Query: 231 DAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQN 290
DA L G TV + + D+NDN P F Q Y + E + +GT V + D D N
Sbjct: 2262 DA--LTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDADSENN 2319
Query: 291 RMTKYSILRGDYQ--DAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRY 348
+M Y I++ Y D F I++ + G+I + LD+E +Q + V + D
Sbjct: 2320 KMVHYQIVQDTYNSTDYFHIDS----SSGLILTARMLDHELVQHCTLKVRSIDSGF---- 2371
Query: 349 MSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQLKE-NQKKPLIGTVLAMDPDAARHS-I 405
P + V I I+DV D PP+F Q Y + E + + V A D D++ +
Sbjct: 2372 --PSLSSEVLVHIYISDVNDNPPVFNQLIYESYVSELAPRGHFVTCVQASDADSSDFDRL 2429
Query: 406 GYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQV 465
YSI +D+ F +K G I + + P Y+L V + T T QV
Sbjct: 2430 EYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLYSLNVSVSDGLFTST-------AQV 2482
Query: 466 HIEVLDENDNAPEFAK-PYQPKVCENAVHGQLVLQISAIDKD 506
HI VL N +P F++ Y +V EN G V+ + A D D
Sbjct: 2483 HIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGD 2524
Score = 127 bits (319), Expect = 4e-29
Identities = 123/434 (28%), Positives = 199/434 (45%), Gaps = 58/434 (13%)
Query: 139 IKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE 198
+ + D+NDN PVF + A+V + GT + VTA+D D G + V Y +
Sbjct: 2072 VNIEDINDNSPVFVGLPYYAAVQVDAEPGTLIYQVTAIDKDK---GPNGEVTYVLQDDYG 2128
Query: 199 YFAID-NSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPF 257
+F I+ NSG +I Y + + A+D G S + + +T+ +N P
Sbjct: 2129 HFEINPNSGNVILKEAFNSDLSNIEYGVTILAKDG-GKPSLSTSVELPITI--VNKAMPV 2185
Query: 258 FTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEG 317
F + YT V ED R+ T + S+ + P+ + Y I+ GD F I+ + G
Sbjct: 2186 FDKPFYTASVNEDIRMNTPILSI---NATSPEGQGIIYIIIDGDPFKQFNID----FDTG 2238
Query: 318 IIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIIN--ITDV-DEPPIFQQ 374
++K + PLDYE Y + A+D G RA+V ++ + DV D PPIF Q
Sbjct: 2239 VLKVVSPLDYEVTSAYKLTIRASDAL---------TGARAEVTVDLLVNDVNDNPPIFDQ 2289
Query: 375 PFYHFQLKENQKKPLIGT----VLAMDPDAARHSIGY--SIRRTSDKGQFFRV-TKKGDI 427
P Y+ L E LIGT V+++D D+ + + + ++ T + +F + + G I
Sbjct: 2290 PTYNTTLSE---ASLIGTPVLQVVSIDADSENNKMVHYQIVQDTYNSTDYFHIDSSSGLI 2346
Query: 428 YNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAK-PYQPK 486
+ LD E+ + T++ + +DS G P+ S V VHI + D NDN P F + Y+
Sbjct: 2347 LTARMLDHELV--QHCTLKVRSIDS-GFPS-LSSEVLVHIYISDVNDNPPVFNQLIYESY 2402
Query: 487 VCENAVHGQLVLQISAIDKD----------ITPRNVKFKFILNTENNFTLTDNHDN---- 532
V E A G V + A D D I N + F++++++ NH
Sbjct: 2403 VSELAPRGHFVTCVQASDADSSDFDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRME 2462
Query: 533 ---TANITVKYGQF 543
+ N++V G F
Sbjct: 2463 PLYSLNVSVSDGLF 2476
Score = 125 bits (313), Expect = 2e-28
Identities = 132/497 (26%), Positives = 212/497 (42%), Gaps = 45/497 (9%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
F + G + + LD E S Y+++ + D G N+ F IKV D NDN P F+
Sbjct: 1406 FDAEKGVGTIVIAKPLDAEQRSIYNMSVEVTD---GTNVAVTQVF-IKVLDNNDNGPEFS 1461
Query: 153 HRLFNASVPESSAVGTSVISVTAVDADDP---TVGDHASVMYQILKGKEYFAIDNSGRII 209
++ ++ E T ++ + A D D+ + H+S+ ++ F ID S ++
Sbjct: 1462 QPNYDVTISEDVLPDTEILQIEATDRDEKHKLSYTVHSSIDSISMR---KFRIDPSTGVL 1518
Query: 210 TITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPE 269
+ LD E Q ++ + + RD Q A V+V ++D ND+ P+FT Y V E
Sbjct: 1519 YTAERLDHEAQDKHILNIMVRD-QEFPYRRNLARVIVNVEDANDHSPYFTNPLYEASVFE 1577
Query: 270 DTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEY 329
+G++V + D D+ +N Y+I G+ + F IE GII K D
Sbjct: 1578 SAALGSAVLQVTALDKDKGENAELIYTIEAGNTGNMFKIEP----VLGIITICKEPDMTT 1633
Query: 330 IQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEP-PIFQQPFYHFQLKENQKKP 388
+ Q+ ++ TD SPP A V I++T D P F Y ++ EN
Sbjct: 1634 MGQFVLSIKVTDQG------SPPMSATAIVRISVTMSDNSHPKFIHKDYQAEVNENVD-- 1685
Query: 389 LIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAK 448
IGT + + ++ ++ Y ++ G F G I +K LD E Y L ++A
Sbjct: 1686 -IGTSVILISAISQSTLIYEVKDGDINGIFTINPYSGVITTQKALDYERTSSYQLIIQAT 1744
Query: 449 ELDSTGTPTGKESIVQVHIEVLDENDNAPEFA-KPYQPKVCENAVHGQLV-------LQI 500
+ G S V+I+++DENDNAP F Y + E A +V L I
Sbjct: 1745 NM------AGMASNATVNIQIVDENDNAPVFLFSQYSGSLSEAAPINSIVRSLDNSPLVI 1798
Query: 501 SAIDKDITPRN--VKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVIS 558
A D D + RN + ++ + +T F D+ H H V +
Sbjct: 1799 RATDAD-SNRNALLVYQIVESTAKKFFTVDSSTGAIRTIANLDHETIAHFHFH---VHVR 1854
Query: 559 DNGMPSRTGTSTLTVAV 575
D+G P T S + V +
Sbjct: 1855 DSGSPQLTAESPVEVNI 1871
Score = 114 bits (285), Expect = 3e-25
Identities = 137/495 (27%), Positives = 212/495 (42%), Gaps = 42/495 (8%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
F +D+ +G + + N+S+ H ++ D G+ T S TI V + D+ FT
Sbjct: 1930 FLIDSNSG----VLTIKNNNLSKDHYMLIVKVSD-GKFYST-SMVTIMVKEAMDSGLHFT 1983
Query: 153 HRLFNASVPESSAVGTSVISVTAVDADDPTVGDHAS--VMYQILKGKEYFAIDN-SGRII 209
++ S+ E++ T++ V V+A VG+ + + Y IL F I + SG I
Sbjct: 1984 QSFYSTSISENN---TNITKVAIVNA----VGNRLNEPLKYSILNPGNKFKIKSTSGVIQ 2036
Query: 210 TITKSLDREKQARYEIVVEA-RDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVP 268
T DRE+Q YE+VVEA R+ LR V V ++DINDN P F Y V
Sbjct: 2037 TTGVPFDREEQELYELVVEASRELDHLR--VARVVVRVNIEDINDNSPVFVGLPYYAAVQ 2094
Query: 269 EDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYE 328
D GT + + D D+ N Y +L+ DY E NP I+K D
Sbjct: 2095 VDAEPGTLIYQVTAIDKDKGPNGEVTY-VLQDDYGH---FEINPNSGNVILKEAFNSDLS 2150
Query: 329 YIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKEN--QK 386
I +Y + A D P ++ I I + P+F +PFY + E+
Sbjct: 2151 NI-EYGVTILAKDGG------KPSLSTSVELPITIVN-KAMPVFDKPFYTASVNEDIRMN 2202
Query: 387 KPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVE 446
P++ ++ A P+ I Y I QF G + LD EV Y LT+
Sbjct: 2203 TPIL-SINATSPEG--QGIIYIIIDGDPFKQFNIDFDTGVLKVVSPLDYEVTSAYKLTIR 2259
Query: 447 AKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQISAIDK 505
A + TG + V V + V D NDN P F +P Y + E ++ G VLQ+ +ID
Sbjct: 2260 ASD-----ALTGARAEVTVDLLVNDVNDNPPIFDQPTYNTTLSEASLIGTPVLQVVSIDA 2314
Query: 506 DITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSR 565
D + I+ N T + D+++ + + D E + L V D+G PS
Sbjct: 2315 DSENNKMVHYQIVQDTYNSTDYFHIDSSSGLILTARMLDHELVQHCTLKVRSIDSGFPSL 2374
Query: 566 TGTSTLTVAVCKCNE 580
+ + + + N+
Sbjct: 2375 SSEVLVHIYISDVND 2389
Score = 110 bits (274), Expect = 7e-24
Identities = 143/536 (26%), Positives = 221/536 (41%), Gaps = 65/536 (12%)
Query: 85 KGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTG---------ENLETPS 135
+G +V V DA++ D +RL+ +S T+ ++D +G + +E
Sbjct: 2409 RGHFVTCVQASDADSSD---FDRLEYSILSGNDRTSFLMDSKSGVITLSNHRKQRMEPLY 2465
Query: 136 SFTIKVHD---------------VNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADD 180
S + V D N P F+ + A V E+ A GT VI V A D D
Sbjct: 2466 SLNVSVSDGLFTSTAQVHIRVLGANLYSPAFSQSTYVAEVRENVAAGTKVIHVRATDGDP 2525
Query: 181 PTVGDHASVMYQILK--GKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGD 238
T G + Y I+ K+ F ID++G++IT T+ LDRE ++ + R G G
Sbjct: 2526 GTYG---QISYAIINDFAKDRFLIDSNGQVIT-TERLDRENPLEGDVSIFVRALDG-GGR 2580
Query: 239 SGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSIL 298
+ TV V + D NDN P F +Y V D G V + DPD+ N YS+
Sbjct: 2581 TTFCTVRVIVVDENDNAPQFMTVEYRASVRADVGRGHLVTQVQAIDPDDGANSRITYSLY 2640
Query: 299 -RGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQ--YSFIVEATDPTIDLRYMSPPAGN 355
A +E +P + + K ++ ++ SF V+A D I +++ P
Sbjct: 2641 SEASVSVADLLEIDPDNGWMVTKG----NFNQLKNTVLSFFVKAVDGGIPVKHSLIP--- 2693
Query: 356 RAQVIINITDVDE-PPIFQQPFYHFQLKENQK-KPLIGTVLAMDPDAARHSIGYSIRRTS 413
V I++ + P F Q Y F + E+ + T+ + S R +
Sbjct: 2694 ---VYIHVLPPETFLPSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPEN 2750
Query: 414 DKGQFFRVTKK-GDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESI---VQVHIEV 469
+KG F + ++ G I +K LDRE P ++ V A P K I V V I+V
Sbjct: 2751 NKGGIFVIEQETGTIKLDKRLDRETSPAFHFKVAAT------IPLDKVDIVFTVDVDIKV 2804
Query: 470 LDENDNAPEF-AKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTEN---NFT 525
LD NDN P F Y + E G + Q+ AID D N + + L++++
Sbjct: 2805 LDLNDNKPVFETSSYDTIIMEGMPVGTKLTQVRAIDMD-WGANGQVTYSLHSDSQPEKVM 2863
Query: 526 LTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMP-SRTGTSTLTVAVCKCNE 580
N D+ D E VV SD G S + T+ ++V V N+
Sbjct: 2864 EAFNIDSNTGWISTLKDLDHETDPTFTFSVVASDLGEAFSLSSTALVSVRVTDIND 2919
Score = 109 bits (272), Expect = 1e-23
Identities = 132/512 (25%), Positives = 220/512 (42%), Gaps = 40/512 (7%)
Query: 108 LDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVG 167
L+RE Y L ++ GE+LE + I+V D+ND P+F+ ++ ++ ES+ +
Sbjct: 117 LNREIQDNYLL--IVKGSVRGEDLEAWTKVNIQVLDMNDLRPLFSPTTYSVTIAESTPLR 174
Query: 168 TSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVV 227
TSV VTA DAD +G + Y + F++ + +I+++ L+ +++ RY++ +
Sbjct: 175 TSVAQVTATDAD---IGSNGEFYYYFKNKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEI 231
Query: 228 EARD----AQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVE 283
A D G G S TA + V ++ IN++ P + VP + + V+
Sbjct: 232 LAVDRGMKLYGNNGVSSTAKLYVHIERINEHAPTIHVVTH---VPFSLEKEPTYAVVTVD 288
Query: 284 DPDEPQN-RMTKYSILRGDYQDAFTI-ETNPAHNEGIIKPMKPLDYE-YIQQYSFIVEAT 340
D D+ N + SI+ GD D F + + NE IK K +D+E + Y+ ++A
Sbjct: 289 DLDDGANGEIESVSIVAGDPLDQFFLAKEGKWLNEYKIKERKQIDWESFPYGYNLTLQAK 348
Query: 341 DPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDA 400
D + + +A I N T P F++ Y + E ++ ++ + P+
Sbjct: 349 DKGSPQKC----SALKAVYIGNPTRDTVPIRFEKEVYDVSISEFSPPGVVVAIVKLSPEP 404
Query: 401 ARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKE 460
+ Y + D F + G I + L+ Y L V KE D
Sbjct: 405 I--DVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEVTNKEGDLK------- 455
Query: 461 SIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILN 519
QV I + D ND+ PEF +P Y V E+ G VL +SA DKD N + +
Sbjct: 456 --AQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKD-KGENGYITYSIA 512
Query: 520 TENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTS-TLTVAVCKC 578
+ N N T + F+ F+ V SD G P R + +T+ +
Sbjct: 513 SLNLLPFVINQFTGVISTTEELDFESSPEIYRFI-VRASDWGSPYRHESEVNVTIRIGNV 571
Query: 579 NEQG---EFTFCEDMAA---QVGVSIQAVVAI 604
N+ E C+ + + VG I AV AI
Sbjct: 572 NDNSPLFEKVACQGVISYDFPVGGHITAVSAI 603
Score = 104 bits (260), Expect = 3e-22
Identities = 114/421 (27%), Positives = 190/421 (45%), Gaps = 41/421 (9%)
Query: 91 KVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGE-NLETPSSFTIKVHDVNDNWP 149
K F VD+ TG + I LD E I+ +H + D + + E+P I+V DVNDN P
Sbjct: 1822 KFFTVDSSTGAIRTIANLDHETIAHFHFHVHVRDSGSPQLTAESPVEVNIEVTDVNDNPP 1881
Query: 150 VFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGK-EYFAIDNSGRI 208
VFT +F + + VG V+ V+A D D + + Y +++G ++F ID++ +
Sbjct: 1882 VFTQAVFETILLLPTYVGVEVLKVSATDPDSEVPPE---LTYSLMEGSLDHFLIDSNSGV 1938
Query: 209 ITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVP 268
+TI + + Y ++V+ D + T+ V + +++ D+ FTQ+ Y+ +
Sbjct: 1939 LTIKN--NNLSKDHYMLIVKVSDGKFY----STSMVTIMVKEAMDSGLHFTQSFYSTSIS 1992
Query: 269 EDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPM-KPLDY 327
E+ T V V N KYSIL + F I++ G+I+ P D
Sbjct: 1993 ENNTNITKVA--IVNAVGNRLNEPLKYSILNPG--NKFKIKS----TSGVIQTTGVPFDR 2044
Query: 328 EYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIF-QQPFYHFQLKENQ 385
E + Y +VEA+ LR R V +NI D+ D P+F P+Y + +
Sbjct: 2045 EEQELYELVVEASRELDHLRVA------RVVVRVNIEDINDNSPVFVGLPYYAAVQVDAE 2098
Query: 386 KKPLIGTVLAMDPDAARH-SIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYP-WYNL 443
LI V A+D D + + Y ++ D G F G++ ++ + ++ Y +
Sbjct: 2099 PGTLIYQVTAIDKDKGPNGEVTYVLQ--DDYGHFEINPNSGNVILKEAFNSDLSNIEYGV 2156
Query: 444 TVEAKELDSTGTPTGKESI-VQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQIS 501
T+ AK+ GK S+ V + + N P F KP Y V E+ +L I+
Sbjct: 2157 TILAKD-------GGKPSLSTSVELPITIVNKAMPVFDKPFYTASVNEDIRMNTPILSIN 2209
Query: 502 A 502
A
Sbjct: 2210 A 2210
Score = 99.8 bits (247), Expect = 9e-21
Identities = 106/422 (25%), Positives = 174/422 (41%), Gaps = 27/422 (6%)
Query: 149 PVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRI 208
P FT ++ ++ E +A+G++V ++ + + + + KG F I+
Sbjct: 2706 PSFTQSQYSFTIAEDTAIGSTVDTLRILPSQNVWFSTVNGERPENNKGG-IFVIEQETGT 2764
Query: 209 ITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVP 268
I + K LDRE + V A T V + + D+NDN P F + Y ++
Sbjct: 2765 IKLDKRLDRETSPAFHFKVAATIPLDKVDIVFTVDVDIKVLDLNDNKPVFETSSYDTIIM 2824
Query: 269 EDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIET-NPAHNEGIIKPMKPLDY 327
E VGT + + D D N YS L D Q +E N N G I +K LD+
Sbjct: 2825 EGMPVGTKLTQVRAIDMDWGANGQVTYS-LHSDSQPEKVMEAFNIDSNTGWISTLKDLDH 2883
Query: 328 EYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQLKENQK 386
E ++F V A+D S A V + +TD+ D P+F Q Y +KE+
Sbjct: 2884 ETDPTFTFSVVASDLGEAFSLSS-----TALVSVRVTDINDNAPVFAQEVYRGNVKESDP 2938
Query: 387 KPLIGTVLA---MDPDAARHSIGYSIRRTSDKGQFF--RVTKKGDIYNEKELDREVYPWY 441
+ VL+ D + Y I + +G+F V + +Y ++ LDRE Y
Sbjct: 2939 PGEVVAVLSTWDRDTSDVNRQVSYHITGGNPRGRFALGLVQSEWKVYVKRPLDREEQDIY 2998
Query: 442 NLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAK-PYQPKVCENAVHGQLVLQI 500
L + T T + V + V D NDN+P + Y + E+ +++L++
Sbjct: 2999 FLNI-------TATDGLFVTQAMVEVSVSDVNDNSPVCDQVAYTALLPEDIPSNKIILKV 3051
Query: 501 SAIDKDITPRN-VKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISD 559
SA D DI +++ + + F L + + DRE V+ L +D
Sbjct: 3052 SAKDADIGSNGYIRYSLYGSGNSEFFLDPESGELKTLAL----LDRERIPVYSLMAKATD 3107
Query: 560 NG 561
G
Sbjct: 3108 GG 3109
Score = 98.6 bits (244), Expect = 2e-20
Identities = 134/575 (23%), Positives = 227/575 (39%), Gaps = 90/575 (15%)
Query: 93 FRVDAETGDVFAIERLDRENISE-YHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVF 151
F ++ TG + E LD E+ E Y D + E+ + TI++ +VNDN P+F
Sbjct: 519 FVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVTIRIGNVNDNSPLF 578
Query: 152 THRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE--YFAIDNSGRII 209
+ VG + +V+A+D D+ + V Y+I+ G E +F ++ ++
Sbjct: 579 EKVACQGVISYDFPVGGHITAVSAIDIDELEL-----VKYKIISGNELGFFYLNPDSGVL 633
Query: 210 TITKSLDRE--KQARYEIVVEARDAQGLRGD----------------------------- 238
+ KSL K + + + A D + L
Sbjct: 634 QLKKSLTNSGIKNGNFALRITATDGENLADPMSINISVLHGKVSSKSFSCRETRVAQKLA 693
Query: 239 -----SGTATVLVTLQD-------INDNFPFFTQTKYTFV-VPEDTRVGTSVGSLFVEDP 285
A + L+D IN P+F ++ + V V ED VG ++ + D
Sbjct: 694 EKLLIKAKANGKLNLEDGFLDFYSINRQGPYFDKSFPSDVAVKEDLPVGANILKIKAYDA 753
Query: 286 DEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTID 345
D N ++I G+ F I+ G +K + P+D E+ Y + D
Sbjct: 754 DSGFNGKVLFTISDGNTDSCFNIDM----ETGQLKVLMPMDREHTDLYLLNITIYD---- 805
Query: 346 LRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQLKENQKKPLIGT----VLAMDPD- 399
+P + + IN+ D D P+F Q Y + E+ IGT V A D D
Sbjct: 806 --LGNPQKSSWRLLTINVEDANDNSPVFIQDSYSVNILESSG---IGTEIIQVEARDKDL 860
Query: 400 AARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGK 459
+ + YS+ +D QF + G +Y +LDRE Y+L +EA++ +G
Sbjct: 861 GSNGEVTYSV--LTDTQQFAINSSTGIVYVADQLDRESKANYSLKIEARDKAESGQQL-- 916
Query: 460 ESIVQVHIEVLDENDNAPEF-AKPYQPKVCENAVHGQLVLQISAIDKDI-TPRNVKFKFI 517
S+V + + + D ND +P F Y KV E+ G ++ + D D+ V++ +
Sbjct: 917 FSVVTLKVFLDDVNDCSPAFIPSSYSVKVLEDLPVGTVIAWLETHDPDLGLGGQVRYSLV 976
Query: 518 LNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMP-SRTGTSTLTVAVC 576
+ F + D + + D E + + L V D G P S + S + V V
Sbjct: 977 NDYNGRFEI----DKASGAIRLSKELDYEKQQFYNLTVRAKDKGRPVSLSSVSFVEVEVV 1032
Query: 577 KCNEQGEFTFCEDMA--------AQVGVSIQAVVA 603
NE + D A +++G S+ V A
Sbjct: 1033 DVNENLHTPYFPDFAVVGSVKENSRIGTSVLQVTA 1067
Score = 79.3 bits (194), Expect = 1e-14
Identities = 72/275 (26%), Positives = 120/275 (43%), Gaps = 17/275 (6%)
Query: 68 VGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDT 127
V +K S + +Y L F+++ +G + L+ Y L T
Sbjct: 395 VAIVKLSPEPIDVEYKLSPGEDAVYFKINPRSGLIVTARPLNTVKKEVYKLEV------T 448
Query: 128 GENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHA 187
+ + + TI + D ND+ P F L++A V ES VGTSV++V+A D D G++
Sbjct: 449 NKEGDLKAQVTISIEDANDHTPEFQQPLYDAYVNESVPVGTSVLTVSASDKDK---GENG 505
Query: 188 SVMYQILKGKEY-FAIDNSGRIITITKSLDREKQAR-YEIVVEARDAQGLRGDSGTATVL 245
+ Y I F I+ +I+ T+ LD E Y +V A D V
Sbjct: 506 YITYSIASLNLLPFVINQFTGVISTTEELDFESSPEIYRFIVRASDWGSPYRHESEVNVT 565
Query: 246 VTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDA 305
+ + ++NDN P F + V+ D VG + ++ D DE + + KY I+ G+
Sbjct: 566 IRIGNVNDNSPLFEKVACQGVISYDFPVGGHITAVSAIDIDELE--LVKYKIISGNELGF 623
Query: 306 FTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEAT 340
F + NP + G+++ K L I+ +F + T
Sbjct: 624 FYL--NP--DSGVLQLKKSLTNSGIKNGNFALRIT 654
Score = 73.2 bits (178), Expect = 9e-13
Identities = 93/348 (26%), Positives = 150/348 (43%), Gaps = 57/348 (16%)
Query: 151 FTHRLFNASVPESSAVGTSV-----ISVTAVDADDPTVGDHASVMYQILKGKE------- 198
FTH ++NA+V E+SA T V + +T +D + Y+I+ G E
Sbjct: 43 FTHSIYNATVYENSAARTYVNSQSRMGITLIDLS-------WDIKYRIVSGDEEGFFKAE 95
Query: 199 --------YFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQ- 249
+ I G I L+RE Q Y ++V+ +RG+ A V +Q
Sbjct: 96 EVIIADFCFLRIRTKGGNSAI---LNREIQDNYLLIVKG----SVRGEDLEAWTKVNIQV 148
Query: 250 -DINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTI 308
D+ND P F+ T Y+ + E T + TSV + D D N Y + D F++
Sbjct: 149 LDMNDLRPLFSPTTYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYF--KNKVDLFSV 206
Query: 309 ETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDE 368
G+I L+Y+ +Y + A D + L Y + + A++ ++I ++E
Sbjct: 207 HP----TSGVISLSGRLNYDEKNRYDLEILAVDRGMKL-YGNNGVSSTAKLYVHIERINE 261
Query: 369 --PPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGD 426
P I F L E + + TV +D A SI QFF + K+G
Sbjct: 262 HAPTIHVVTHVPFSL-EKEPTYAVVTVDDLDDGANGEIESVSIVAGDPLDQFF-LAKEGK 319
Query: 427 IYNE------KELDREVYPW-YNLTVEAKELDSTGTPTGKESIVQVHI 467
NE K++D E +P+ YNLT++AK+ G+P ++ V+I
Sbjct: 320 WLNEYKIKERKQIDWESFPYGYNLTLQAKD---KGSPQKCSALKAVYI 364
>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
Length = 840
Score = 199 bits (507), Expect = 6e-51
Identities = 186/659 (28%), Positives = 294/659 (44%), Gaps = 48/659 (7%)
Query: 20 VAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRK- 78
+ V +A N + + H+ +R KR W + E P HV +I+S ++
Sbjct: 107 IKVVLSARENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNY 166
Query: 79 NAKYLLKGEYVGK----VFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETP 134
Y + G V K +F ++ +TGD+F +DRE ++ L D G E P
Sbjct: 167 TIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTAD-GYAPEYP 225
Query: 135 SSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQIL 194
IK+ D NDN P F HR+ +VPE+ GTSV VTA D D+P H + Y+IL
Sbjct: 226 LPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDT-LHTRLKYKIL 284
Query: 195 K-----GKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLR-GDSGTATVLVTL 248
+ K + ++G I T T LDREK Y++++E RD G G T T+ ++L
Sbjct: 285 QQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISL 344
Query: 249 QDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTK--YSILRGDYQDAF 306
+D NDN P FT+T Y V E+ R+ + + V+D D P +K Y IL+G+ F
Sbjct: 345 EDENDNPPSFTETSYVTEV-EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNF 403
Query: 307 TIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS--PPAGNRAQVIINIT 364
I T+P NEG++ +KPL+YE +Q V + + S P V + I
Sbjct: 404 IISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKII 463
Query: 365 DVDEPPIFQQPFYHFQLKEN--QKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVT 422
D DE P P Q ++ + L+G A+DP+ + G ++ D+ +F +
Sbjct: 464 DSDEGPECHPPVKVIQSQDGFPAGQELLG-YKALDPEISSGE-GLRYQKLGDEDNWFEIN 521
Query: 423 K-KGDIYNEKELDRE----VYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAP 477
+ GD+ K LDRE YN++V A +D+ G + VH++ D ND+AP
Sbjct: 522 QHTGDLRTLKVLDRESKFVKNNQYNISVVA--VDAVGRSC--TGTLVVHLD--DYNDHAP 575
Query: 478 EFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFIL--NTENNFTLTDNHDNTAN 535
+ K + +C+N + + +D D F+F L + N+ + + TA
Sbjct: 576 QIDK--EVTICQN---NEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWNIEEKDGKTAI 630
Query: 536 ITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVG 595
+ R++ ++ V I T LTV VC C+ E + V
Sbjct: 631 LR------QRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVR 684
Query: 596 VSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPE--IHEQLVTYDEEGGGE 652
++ +L ++ +V+ L I R K PE + L+ + EG GE
Sbjct: 685 PNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGE 743
>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
sapiens]
Length = 894
Score = 199 bits (507), Expect = 6e-51
Identities = 186/659 (28%), Positives = 294/659 (44%), Gaps = 48/659 (7%)
Query: 20 VAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRK- 78
+ V +A N + + H+ +R KR W + E P HV +I+S ++
Sbjct: 107 IKVVLSARENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNY 166
Query: 79 NAKYLLKGEYVGK----VFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETP 134
Y + G V K +F ++ +TGD+F +DRE ++ L D G E P
Sbjct: 167 TIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTAD-GYAPEYP 225
Query: 135 SSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQIL 194
IK+ D NDN P F HR+ +VPE+ GTSV VTA D D+P H + Y+IL
Sbjct: 226 LPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDT-LHTRLKYKIL 284
Query: 195 K-----GKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLR-GDSGTATVLVTL 248
+ K + ++G I T T LDREK Y++++E RD G G T T+ ++L
Sbjct: 285 QQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISL 344
Query: 249 QDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTK--YSILRGDYQDAF 306
+D NDN P FT+T Y V E+ R+ + + V+D D P +K Y IL+G+ F
Sbjct: 345 EDENDNPPSFTETSYVTEV-EENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNF 403
Query: 307 TIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS--PPAGNRAQVIINIT 364
I T+P NEG++ +KPL+YE +Q V + + S P V + I
Sbjct: 404 IISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKII 463
Query: 365 DVDEPPIFQQPFYHFQLKEN--QKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVT 422
D DE P P Q ++ + L+G A+DP+ + G ++ D+ +F +
Sbjct: 464 DSDEGPECHPPVKVIQSQDGFPAGQELLG-YKALDPEISSGE-GLRYQKLGDEDNWFEIN 521
Query: 423 K-KGDIYNEKELDRE----VYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAP 477
+ GD+ K LDRE YN++V A +D+ G + VH++ D ND+AP
Sbjct: 522 QHTGDLRTLKVLDRESKFVKNNQYNISVVA--VDAVGRSC--TGTLVVHLD--DYNDHAP 575
Query: 478 EFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFIL--NTENNFTLTDNHDNTAN 535
+ K + +C+N + + +D D F+F L + N+ + + TA
Sbjct: 576 QIDK--EVTICQN---NEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWNIEEKDGKTAI 630
Query: 536 ITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVG 595
+ R++ ++ V I T LTV VC C+ E + V
Sbjct: 631 LR------QRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVR 684
Query: 596 VSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPE--IHEQLVTYDEEGGGE 652
++ +L ++ +V+ L I R K PE + L+ + EG GE
Sbjct: 685 PNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGE 743
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 193 bits (490), Expect = 6e-49
Identities = 161/507 (31%), Positives = 235/507 (46%), Gaps = 28/507 (5%)
Query: 82 YLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKV 141
Y + G F +D ETG + + LDRE +Y L + D + + V
Sbjct: 754 YAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYDLGIPQKAAWRLLHVVVV 813
Query: 142 HDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFA 201
D NDN P F + V E V + +I V A D D +G + V Y I+ + F+
Sbjct: 814 -DANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKD---LGPNGHVTYSIVTDTDTFS 869
Query: 202 IDNSGRIITITKSLDREKQARYEIVVEARD-AQGLRGDSGTATVLVTLQDINDNFPFFTQ 260
ID+ ++ I + LDRE Q + + +EARD A+ T V V+L+D+NDN P F
Sbjct: 870 IDSVTGVVNIARPLDRELQHEHSLKIEARDQAREEPQLFSTVVVKVSLEDVNDNPPTFIP 929
Query: 261 TKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDA-FTIETNPAHNEGII 319
Y V ED GT + L DPD Q+ +YS+L D+ + F ++ G +
Sbjct: 930 PNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLL--DHGEGNFDVD----KLSGAV 983
Query: 320 KPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDE---PPIFQQPF 376
+ ++ LD+E Q Y+ V A D + S V + + DV+E PP+F
Sbjct: 984 RIVQQLDFEKKQVYNLTVRAKDKGKPVSLSS-----TCYVEVEVVDVNENLHPPVFSSFV 1038
Query: 377 YHFQLKENQK-KPLIGTVLAMDPDAARH-SIGYSIRRTSDKGQFFRVTKKGDIYNEKELD 434
+KE+ L+ TV A D DA R I YSIR S G F + G I LD
Sbjct: 1039 EKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSIRDGSGVGVFKIGEETGVIETSDRLD 1098
Query: 435 REVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVH 493
RE Y LTV A D P S ++++IEV D NDNAP+ ++P Y P++ EN+
Sbjct: 1099 RESTSHYWLTVFA--TDQGVVPL--SSFIEIYIEVEDVNDNAPQTSEPVYYPEIMENSPK 1154
Query: 494 GQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFL 553
V+QI A D D + N K + + + N H T IT + DRE H L
Sbjct: 1155 DVSVVQIEAFDPD-SSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQDEHIL 1213
Query: 554 PVVISDNGMPSRTGTSTLTVAVCKCNE 580
V ++DNG P ++ + + V + N+
Sbjct: 1214 EVTVTDNGSPPKSTIARVIVKILDEND 1240
Score = 191 bits (484), Expect = 3e-48
Identities = 162/507 (31%), Positives = 249/507 (49%), Gaps = 32/507 (6%)
Query: 77 RKNAK--YLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETP 134
R NA+ Y L G K F+++ +TG++ LDRE + YHL D G
Sbjct: 3053 RSNAEITYTLLGSGAEK-FKLNPDTGELKTSTPLDREEQAVYHLLVRATD---GGGRFCQ 3108
Query: 135 SSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQIL 194
+S + + DVNDN P F+ + +V E++ GT + V A DAD G + ++Y ++
Sbjct: 3109 ASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDAD---AGLNRKILYSLI 3165
Query: 195 KGKE-YFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGL-RGDSGTATVLVTLQDIN 252
+ F+I+ II + K LDRE QA Y + ++A D QGL R + T TV+V++ DIN
Sbjct: 3166 DSADGQFSINELSGIIQLEKPLDRELQAVYTLSLKAVD-QGLPRRLTATGTVIVSVLDIN 3224
Query: 253 DNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNP 312
DN P F +Y V ED VGT V ++ D N YSI+ G+ F+I++
Sbjct: 3225 DNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDS-- 3282
Query: 313 AHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPI 371
G + ++ LDYE +Y VEATD +P + A V +N+TD+ D P+
Sbjct: 3283 --KTGAVFIIENLDYESSHEYYLTVEATDGG------TPSLSDVATVNVNVTDINDNTPV 3334
Query: 372 FQQPFYHFQLKENQ-KKPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYN 429
F Q Y + E+ + + TV+A D D +S I YSI + F +G++
Sbjct: 3335 FSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKV 3394
Query: 430 EKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAK-PYQPKVC 488
K LDRE Y LTV+A + G+P + + V+I+V D NDNAP F++ Y +
Sbjct: 3395 TKLLDRETISGYTLTVQASD---NGSPP-RVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQ 3450
Query: 489 ENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHT 548
EN G VLQ+ D+D + F F + T N+ + N + + R+
Sbjct: 3451 ENKPVGFSVLQLVVTDEDSSHNGPPFFFTIVTGNDEKAFE--VNPQGVLLTSSAIKRKEK 3508
Query: 549 KVHFLPVVISDNGMPSRTGTSTLTVAV 575
+ L V ++DNG P + + + + V
Sbjct: 3509 DHYLLQVKVADNGKPQLSSLTYIDIRV 3535
Score = 173 bits (439), Expect = 5e-43
Identities = 161/547 (29%), Positives = 260/547 (47%), Gaps = 52/547 (9%)
Query: 75 VSRKNAKYLLKGEYVGKVFRVDAETGD--VFAIERLDRENISEYHLTAVIVDKDTGENLE 132
++R+ ++ G+ +G+ F V+ + V+ + LDRE Y LT D
Sbjct: 2950 INRQVTYFITGGDPLGQ-FAVETIQNEWKVYVKKPLDREKRDNYLLTITATDG----TFS 3004
Query: 133 TPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQ 192
+ + +KV D NDN PV L++ ++PE G ++ ++A DAD + +A + Y
Sbjct: 3005 SKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDAD---IRSNAEITYT 3061
Query: 193 IL-KGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDI 251
+L G E F ++ + + LDRE+QA Y ++V A D G A++++TL+D+
Sbjct: 3062 LLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGGGRFCQ---ASIVLTLEDV 3118
Query: 252 NDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETN 311
NDN P F+ Y V E+T GT + + D D NR YS++ D+ + +
Sbjct: 3119 NDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLI-----DSADGQFS 3173
Query: 312 PAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPP 370
GII+ KPLD E Y+ ++A D + R + VI+++ D+ D PP
Sbjct: 3174 INELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTAT-----GTVIVSVLDINDNPP 3228
Query: 371 IFQQPFYHFQLKENQKKPLIGT----VLAMDPDA-ARHSIGYSIRRTSDKGQFFRVTKKG 425
+F+ Y + E+ L+GT V A D A I YSI ++ G+F +K G
Sbjct: 3229 VFEYREYGATVSEDI---LVGTEVLQVYAASRDIEANAEITYSIISGNEHGKFSIDSKTG 3285
Query: 426 DIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKP-YQ 484
++ + LD E Y LTVEA + GTP+ + + V++ V D NDN P F++ Y
Sbjct: 3286 AVFIIENLDYESSHEYYLTVEATD---GGTPSLSD-VATVNVNVTDINDNTPVFSQDTYT 3341
Query: 485 PKVCENAVHGQLVLQISAIDKDITPRNVKFKFIL---NTENNFTLTDNHDNTANITVKYG 541
+ E+AV Q V+ + A D D P N + + N ++FT+ D +T
Sbjct: 3342 TVISEDAVLEQSVITVMADDAD-GPSNSHIHYSIIDGNQGSSFTI-DPVRGEVKVTKL-- 3397
Query: 542 QFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE------QGEFTFCEDMAAQVG 595
DRE + L V SDNG P R T+T+ + V N+ +G ++ VG
Sbjct: 3398 -LDRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVG 3456
Query: 596 VSIQAVV 602
S+ +V
Sbjct: 3457 FSVLQLV 3463
Score = 154 bits (389), Expect = 3e-37
Identities = 167/589 (28%), Positives = 252/589 (42%), Gaps = 61/589 (10%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
F ++ ETG + ++ LD E Y + V D L + + + V DVND+ P FT
Sbjct: 2860 FAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFT 2919
Query: 153 HRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE--YFAID---NSGR 207
++ +V E G + ++ DAD + + V Y I G FA++ N +
Sbjct: 2920 AEIYKGTVSEDDPQGGVIAILSTTDADSEEI--NRQVTYFITGGDPLGQFAVETIQNEWK 2977
Query: 208 IITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVV 267
+ + K LDREK+ Y + + A D S A V V + D NDN P +T Y+ +
Sbjct: 2978 VY-VKKPLDREKRDNYLLTITATDGT----FSSKAIVEVKVLDANDNSPVCEKTLYSDTI 3032
Query: 268 PEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDY 327
PED G + + D D N Y++L G + F + NP + G +K PLD
Sbjct: 3033 PEDVLPGKLIMQISATDADIRSNAEITYTLL-GSGAEKFKL--NP--DTGELKTSTPLDR 3087
Query: 328 EYIQQYSFIVEATDPTIDLRYMSPPAGNR---AQVIINITDV-DEPPIFQQPFYHFQLKE 383
E Y +V ATD G R A +++ + DV D P F Y + E
Sbjct: 3088 EEQAVYHLLVRATD-----------GGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFE 3136
Query: 384 N-QKKPLIGTVLAMDPDAA-RHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWY 441
N + L+ V A D DA I YS+ ++D GQF G I EK LDRE+ Y
Sbjct: 3137 NTEPGTLLTRVQATDADAGLNRKILYSLIDSAD-GQFSINELSGIIQLEKPLDRELQAVY 3195
Query: 442 NLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFA-KPYQPKVCENAVHGQLVLQI 500
L+++A + G P + V + VLD NDN P F + Y V E+ + G VLQ+
Sbjct: 3196 TLSLKAVD---QGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQV 3252
Query: 501 SAIDKDITPR-NVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISD 559
A +DI + + I E+ D+ I D E + ++L V +D
Sbjct: 3253 YAASRDIEANAEITYSIISGNEHGKFSIDSKTGAVFI---IENLDYESSHEYYLTVEATD 3309
Query: 560 NGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLLIF 619
G PS + +T+ V V N+ F +D V +S AV L +VIT++
Sbjct: 3310 GGTPSLSDVATVNVNVTDINDNTP-VFSQDTYTTV-ISEDAV-------LEQSVITVM-- 3358
Query: 620 LRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRR 668
A G S IH ++ ++ +D +V V + R
Sbjct: 3359 -------ADDADGPSNSHIHYSIIDGNQGSSFTIDPVRGEVKVTKLLDR 3400
Score = 138 bits (347), Expect = 2e-32
Identities = 132/464 (28%), Positives = 208/464 (44%), Gaps = 51/464 (10%)
Query: 91 KVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPV 150
K FR+D TG ++ E+LD E + ++ LT ++ D+D + + V D ND+ P
Sbjct: 1503 KKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRDQDVPVK-RNFARIVVNVSDTNDHAPW 1561
Query: 151 FTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGK--EYFAIDNSGRI 208
FT + V ES+AVG+ V+ VTA+D D G +A V+Y I G F ID
Sbjct: 1562 FTASSYKGRVYESAAVGSVVLQVTALDKDK---GKNAEVLYSIESGNIGNSFMIDPVLGS 1618
Query: 209 ITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVP 268
I K LDR QA Y+++V+A D +G S +V + + ++ P FT +Y+ +
Sbjct: 1619 IKTAKELDRSNQAEYDLMVKATD-KGSPPMSEITSVRIFVTIADNASPKFTSKEYSVELS 1677
Query: 269 EDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYE 328
E +G+ VG + Y I G+ DAF I NP + G I K LD+E
Sbjct: 1678 ETVSIGSFVGMVTAHSQSS-----VVYEIKDGNTGDAFDI--NP--HSGTIITQKALDFE 1728
Query: 329 YIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKE----- 383
+ Y+ I++ T+ M+ + N ++ + D P+F Q Y + E
Sbjct: 1729 TLPIYTLIIQGTN-------MAGLSTNTTVLVHLQDENDNAPVFMQAEYTGLISESASIN 1781
Query: 384 -----NQKKPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREV 437
++ PL+ + A D D ++ + Y I S F + G I+ LD E
Sbjct: 1782 SVVLTDRNVPLV--IRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVLSLDYEE 1839
Query: 438 YPWYNLTVEAKELDSTGTP-TGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQ 495
++ TV+ ++ GTP E V + V+D ND P FAKP Y+ + G
Sbjct: 1840 TSIFHFTVQVHDM---GTPRLFAEYAANVTVHVIDINDCPPVFAKPLYEASLLLPTYKGV 1896
Query: 496 LVLQISAIDKD----------ITPRNVKFKFILNTENNFTLTDN 529
V+ ++A D D IT N+ KF ++ + N
Sbjct: 1897 KVITVNATDADSSAFSQLIYSITEGNIGEKFSMDYKTGALTVQN 1940
Score = 137 bits (344), Expect = 5e-32
Identities = 135/485 (27%), Positives = 205/485 (42%), Gaps = 45/485 (9%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
F VD TG + + LD E S Y+LT D T + IKV D ND+ P F+
Sbjct: 1402 FDVDKGTGTIIVAKPLDAEQKSNYNLTVEATDGTT----TILTQVFIKVIDTNDHRPQFS 1457
Query: 153 HRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE-----YFAIDNSGR 207
+ +PE +A T ++ ++AVD D+ ++Y + ++ F +D +
Sbjct: 1458 TSKYEVVIPEDTAPETEILQISAVDQDEKN-----KLIYTLQSSRDPLSLKKFRLDPATG 1512
Query: 208 IITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVV 267
+ ++ LD E ++ + V RD Q + A ++V + D ND+ P+FT + Y V
Sbjct: 1513 SLYTSEKLDHEAVHQHTLTVMVRD-QDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRV 1571
Query: 268 PEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDY 327
E VG+ V + D D+ +N YSI G+ ++F I+ G IK K LD
Sbjct: 1572 YESAAVGSVVLQVTALDKDKGKNAEVLYSIESGNIGNSFMIDP----VLGSIKTAKELDR 1627
Query: 328 EYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDE-PPIFQQPFYHFQLKENQK 386
+Y +V+ATD SPP V I +T D P F Y +L E
Sbjct: 1628 SNQAEYDLMVKATDKG------SPPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVS 1681
Query: 387 KPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVE 446
IG+ + M ++ S+ Y I+ + F G I +K LD E P Y L ++
Sbjct: 1682 ---IGSFVGMVTAHSQSSVVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQ 1738
Query: 447 AKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAK-PYQPKVCENAVHGQLVLQ------ 499
+ T T V VH++ DENDNAP F + Y + E+A +VL
Sbjct: 1739 GTNMAGLSTNT----TVLVHLQ--DENDNAPVFMQAEYTGLISESASINSVVLTDRNVPL 1792
Query: 500 -ISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVIS 558
I A D D + I+ + + A TV D E T + V +
Sbjct: 1793 VIRAADADKDSNALLVYHIVEPSVHTYFAIDSSTGAIHTVL--SLDYEETSIFHFTVQVH 1850
Query: 559 DNGMP 563
D G P
Sbjct: 1851 DMGTP 1855
Score = 135 bits (340), Expect = 1e-31
Identities = 133/492 (27%), Positives = 216/492 (43%), Gaps = 34/492 (6%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
F ++ TG + I LD E Y L+ D TG + E I V D+NDN PVF
Sbjct: 2227 FTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEV--FVDIIVDDINDNPPVFA 2284
Query: 153 HRLFNASVPESSAVGTSVISVTAVDAD-DPTVGDHASVMYQILKGKEYFAIDNSGRIITI 211
+ + ++ E+S +GTSV+ V A D+D +P G + K ++F +D+S +I++
Sbjct: 2285 QQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKSHDHFHVDSSTGLISL 2344
Query: 212 TKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDT 271
++LD E+ ++ I V A D G+ S V V + D+NDN P F Q Y + E
Sbjct: 2345 LRTLDYEQSRQHTIFVRAVDG-GMPTLSSDVIVTVDVTDLNDNPPLFEQQIYEARISEHA 2403
Query: 272 RVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQ 331
G V + D D +YSIL G+ F I++ GII +
Sbjct: 2404 PHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDS----ATGIITLSNLHRHALKP 2459
Query: 332 QYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVD---EPPIFQQPFYHFQLKENQK-K 387
YS + +D R+ +++T + P F Q Y +L EN
Sbjct: 2460 FYSLNLSVSDGVF-----------RSSTQVHVTVIGGNLHSPAFLQNEYEVELAENAPLH 2508
Query: 388 PLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVE 446
L+ V D D+ + + Y I K +F+ + ++G I+ ++LDRE ++V
Sbjct: 2509 TLVMEVKTTDGDSGIYGHVTYHIVNDFAKDRFY-INERGQIFTLEKLDRETPAEKVISVR 2567
Query: 447 AKELDSTGTPTGKESIVQVHIEVLDENDNAPEF-AKPYQPKVCENAVHGQLVLQISAIDK 505
D+ GK + V++ + D+NDNAP+F A Y+ + +A G V+++ A D
Sbjct: 2568 LMAKDA----GGKVAFCTVNVILTDDNDNAPQFRATKYEVNIGSSAAKGTSVVKVLASDA 2623
Query: 506 DITPRNVKFKFILNTENNFTLTDNHDNTAN--ITVKYGQFDREHTKVHFLPVVISDNGMP 563
D N + + ++ + N + IT K E+ F V DNG P
Sbjct: 2624 D-EGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLENEFFTFF-VRAVDNGSP 2681
Query: 564 SRTGTSTLTVAV 575
S+ + V +
Sbjct: 2682 SKESVVLVYVKI 2693
Score = 134 bits (336), Expect = 4e-31
Identities = 141/516 (27%), Positives = 225/516 (43%), Gaps = 55/516 (10%)
Query: 86 GEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVN 145
G VG VF++ ETG + +RLDRE+ S Y LT D+ L + I+V DVN
Sbjct: 1076 GSGVG-VFKIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVP-LSSFIEIYIEVEDVN 1133
Query: 146 DNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE--YFAID 203
DN P + ++ + E+S SV+ + A D D + + +MY+I G +F+I
Sbjct: 1134 DNAPQTSEPVYYPEIMENSPKDVSVVQIEAFDPDSSS---NDKLMYKITSGNPQGFFSIH 1190
Query: 204 -NSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTK 262
+G I T ++ LDRE+Q + + V D G S A V+V + D NDN P F Q
Sbjct: 1191 PKTGLITTTSRKLDREQQDEHILEVTVTD-NGSPPKSTIARVIVKILDENDNKPQFLQKF 1249
Query: 263 YTFVVPEDTRVGTSVGS-------LFVEDPDEPQNRMTKYSILRGDYQDAFTIETN---- 311
Y +PE + + + D DE N YSI G+ F IE
Sbjct: 1250 YKIRLPEREKPDRERNARREPLYHVIATDKDEGPNAEISYSIEDGNEHGKFFIEPKTGVV 1309
Query: 312 -----PAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV 366
A E I +K +D Q +++ + + ++S P +
Sbjct: 1310 SSKRFSAAGEYDILSIKAVDNGRPQ------KSSTTRLHIEWISKPKPSL---------- 1353
Query: 367 DEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGD 426
EP F++ F+ F + E+ + V++++P + + I + F G
Sbjct: 1354 -EPISFEESFFTFTVMESDPVAHMIGVISVEPPGI--PLWFDITGGNYDSHFDVDKGTGT 1410
Query: 427 IYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFA-KPYQP 485
I K LD E YNLTVEA + GT T + QV I+V+D ND+ P+F+ Y+
Sbjct: 1411 IIVAKPLDAEQKSNYNLTVEATD----GTTT---ILTQVFIKVIDTNDHRPQFSTSKYEV 1463
Query: 486 KVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTD-NHDNTANITVKYGQFD 544
+ E+ +LQISA+D+D +N + ++ + +L D + D
Sbjct: 1464 VIPEDTAPETEILQISAVDQD--EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLD 1521
Query: 545 REHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 580
E H L V++ D +P + + + V V N+
Sbjct: 1522 HEAVHQHTLTVMVRDQDVPVKRNFARIVVNVSDTND 1557
Score = 130 bits (326), Expect = 6e-30
Identities = 144/520 (27%), Positives = 228/520 (43%), Gaps = 63/520 (12%)
Query: 78 KNAK--YLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPS 135
KNA+ Y ++ +G F +D G + + LDR N +EY L DK + E +
Sbjct: 1593 KNAEVLYSIESGNIGNSFMIDPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEI-T 1651
Query: 136 SFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILK 195
S I V ++ P FT + ++ + E+ ++G+ V VTA +SV+Y+I
Sbjct: 1652 SVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTA--------HSQSSVVYEIKD 1703
Query: 196 GKEYFAID---NSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDIN 252
G A D +SG IIT K+LD E Y ++++ + GL S TVLV LQD N
Sbjct: 1704 GNTGDAFDINPHSGTIIT-QKALDFETLPIYTLIIQGTNMAGL---STNTTVLVHLQDEN 1759
Query: 253 DNFPFFTQTKYTFVVPEDTRVGTSVGS-------LFVEDPDEPQNRMTKYSILRGDYQDA 305
DN P F Q +YT ++ E + + V + + D D+ N + Y I+
Sbjct: 1760 DNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSNALLVYHIVEPSVHTY 1819
Query: 306 FTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPP---AGNRAQVIIN 362
F I++ + G I + LDYE + F V+ D M P A A V ++
Sbjct: 1820 FAIDS----STGAIHTVLSLDYEETSIFHFTVQVHD-------MGTPRLFAEYAANVTVH 1868
Query: 363 ITDVDE-PPIFQQPFYHFQ-LKENQKKPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFF 419
+ D+++ PP+F +P Y L K + TV A D D++ S + YSI + +F
Sbjct: 1869 VIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFS 1928
Query: 420 RVTKKG--DIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAP 477
K G + N +L Y LTV A + G + V I V + ++
Sbjct: 1929 MDYKTGALTVQNTTQLRSR----YELTVRASDGRFAG-------LTSVKINVKESKESHL 1977
Query: 478 EFAKP-YQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANI 536
+F + Y V EN+ + + I+AI I F ILN + F ++ T+ +
Sbjct: 1978 KFTQDVYSAVVKENSTEAETLAVITAIGNPI--NEPLFYHILNPDRRFKIS----RTSGV 2031
Query: 537 TVKYG-QFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAV 575
G FDRE + + V +++ PS + V V
Sbjct: 2032 LSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIV 2071
Score = 125 bits (313), Expect = 2e-28
Identities = 143/525 (27%), Positives = 216/525 (41%), Gaps = 80/525 (15%)
Query: 85 KGEYVGKVFRVDAETGD----VFAIERLD---RENISEYHLTAVIVDKDTGENLETPSSF 137
KG V KV DA+ G +AIE +EN+ L+ VI K++ LE F
Sbjct: 2611 KGTSVVKVLASDADEGSNADITYAIEADSESVKENLEINKLSGVITTKESLIGLEN-EFF 2669
Query: 138 TIKVHDVNDN--------------------WPVFTHRLFNASVPESSAVGTSVISVTAVD 177
T V V++ P F+ + +V E +GT + + A
Sbjct: 2670 TFFVRAVDNGSPSKESVVLVYVKILPPEMQLPKFSEPFYTFTVSEDVPIGTEIDLIRAEH 2729
Query: 178 ADDPTVGDHASVMYQILKGK-------EYFAIDNSGRIITITKSLDREKQARYEIVVEAR 230
+ +V+Y ++KG E F ID + + KSLD E Y+ + AR
Sbjct: 2730 S--------GTVLYSLVKGNTPESNRDESFVIDRQSGRLKLEKSLDHETTKWYQFSILAR 2781
Query: 231 DAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQN 290
Q + V + ++D NDN P F + Y + E+ G+ V + D D N
Sbjct: 2782 CTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVENLPGGSRVIQIRASDADSGTN 2841
Query: 291 RMTKYSILRGDYQDAFTIETNPAHNE-GIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYM 349
YS+ Q IE+ + E G I +K LD+E Y V A+D ++
Sbjct: 2842 GQVMYSL--DQSQSVEVIESFAINMETGWITTLKELDHEKRDNYQIKVVASDHGEKIQLS 2899
Query: 350 SPPAGNRAQVIINITDV-DEPPIFQQPFYHFQLKENQKKPLIGTVLA---MDPDAARHSI 405
S A V + +TDV D PP F Y + E+ + + +L+ D + +
Sbjct: 2900 S-----TAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVIAILSTTDADSEEINRQV 2954
Query: 406 GYSIRRTSDKGQFFRVTKKGD--IYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIV 463
Y I GQF T + + +Y +K LDRE Y LT+ A + GT + K
Sbjct: 2955 TYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATD----GTFSSK---A 3007
Query: 464 QVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTEN 522
V ++VLD NDN+P K Y + E+ + G+L++QISA D DI N E
Sbjct: 3008 IVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDADIRS---------NAEI 3058
Query: 523 NFTLTDNHDNTANITVKYGQ------FDREHTKVHFLPVVISDNG 561
+TL + + G+ DRE V+ L V +D G
Sbjct: 3059 TYTLLGSGAEKFKLNPDTGELKTSTPLDREEQAVYHLLVRATDGG 3103
Score = 124 bits (312), Expect = 3e-28
Identities = 126/433 (29%), Positives = 198/433 (45%), Gaps = 35/433 (8%)
Query: 142 HDVNDNWPVFTHRL-FNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE-- 198
H VN + P F L V E+ VG+SVI + + D D G + ++Y + G E
Sbjct: 707 HSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDLD---TGFNGKLVYAVSGGNEDS 763
Query: 199 YFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFF 258
F ID ++ I LDRE +Y + + D G+ + + V + D NDN P F
Sbjct: 764 CFMIDMETGMLKILSPLDRETTDKYTLNITVYDL-GIPQKAAWRLLHVVVVDANDNPPEF 822
Query: 259 TQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGI 318
Q Y V ED V + + + D D N YSI+ D F+I++ G+
Sbjct: 823 LQESYFVEVSEDKEVHSEIIQVEATDKDLGPNGHVTYSIVTD--TDTFSIDS----VTGV 876
Query: 319 IKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFY 377
+ +PLD E ++S +EA D + P + V +++ DV D PP F P Y
Sbjct: 877 VNIARPLDRELQHEHSLKIEARDQARE----EPQLFSTVVVKVSLEDVNDNPPTFIPPNY 932
Query: 378 HFQLKENQKKPLIGTVL----AMDPDAARH-SIGYSIRRTSDKGQFFRVTKKGDIYNEKE 432
+++E+ + GTV+ A DPD + + YS+ +G F G + ++
Sbjct: 933 RVKVREDLPE---GTVIMWLEAHDPDLGQSGQVRYSL-LDHGEGNFDVDKLSGAVRIVQQ 988
Query: 433 LDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDN--APEFAKPYQP-KVCE 489
LD E YNLTV AK+ G P S V +EV+D N+N P F+ + V E
Sbjct: 989 LDFEKKQVYNLTVRAKD---KGKPVSLSSTCYVEVEVVDVNENLHPPVFSSFVEKGTVKE 1045
Query: 490 NAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTK 549
+A G LV+ +SA D+D R+ + ++ + + + + T I + DRE T
Sbjct: 1046 DAPVGSLVMTVSAHDED-ARRDGEIRYSIRDGSGVGVFKIGEETGVIETS-DRLDRESTS 1103
Query: 550 VHFLPVVISDNGM 562
++L V +D G+
Sbjct: 1104 HYWLTVFATDQGV 1116
Score = 114 bits (286), Expect = 3e-25
Identities = 134/503 (26%), Positives = 226/503 (44%), Gaps = 51/503 (10%)
Query: 89 VGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNW 148
+G+ F +D +TG L +N ++ + + + +S I V + ++
Sbjct: 1923 IGEKFSMDYKTG------ALTVQNTTQLRSRYELTVRASDGRFAGLTSVKINVKESKESH 1976
Query: 149 PVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRI 208
FT +++A V E+S ++ +TA+ +P + + Y IL F I + +
Sbjct: 1977 LKFTQDVYSAVVKENSTEAETLAVITAIG--NPI---NEPLFYHILNPDRRFKISRTSGV 2031
Query: 209 ITITKS-LDREKQARYEIVVEARDAQGLRGDSGTATVLVTL--QDINDNFPFFTQTKYTF 265
++ T + DRE+Q +++VVE + S A V+V + +D NDN P F Y
Sbjct: 2032 LSTTGTPFDREQQEAFDVVVEVTEEHK---PSAVAHVVVKVIVEDQNDNAPVFVNLPYYA 2088
Query: 266 VVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPL 325
VV DT VG + + D D +N Y + ++ + F I P G I K
Sbjct: 2089 VVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLK--EHHEHFQI--GPL---GEISLKKQF 2141
Query: 326 DYEYI-QQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEP-PIFQQPFYHFQLKE 383
+ + + ++Y V A D PA + A+VI+ IT +++ P+F++PFY ++ E
Sbjct: 2142 ELDTLNKEYLVTVVAKDG-------GNPAFS-AEVIVPITVMNKAMPVFEKPFYSAEIAE 2193
Query: 384 N-QKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYN 442
+ Q + V A P+ + + YSI QF G I LD E +P Y
Sbjct: 2194 SIQVHSPVVHVQANSPEGLK--VFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYK 2251
Query: 443 LTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQIS 501
L++ A T + TG + V V I V D NDN P FA+ Y + E +V G V+Q+
Sbjct: 2252 LSIRA-----TDSLTGAHAEVFVDIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVR 2306
Query: 502 AIDKDITP-RNVKFKFILNTENNFTLTDNH---DNTANITVKYGQFDREHTKVHFLPVVI 557
A D D P R + ++ N + + +H D++ + D E ++ H + V
Sbjct: 2307 ATDSDSEPNRGISYQMF----GNHSKSHDHFHVDSSTGLISLLRTLDYEQSRQHTIFVRA 2362
Query: 558 SDNGMPSRTGTSTLTVAVCKCNE 580
D GMP+ + +TV V N+
Sbjct: 2363 VDGGMPTLSSDVIVTVDVTDLND 2385
Score = 113 bits (282), Expect = 8e-25
Identities = 131/510 (25%), Positives = 218/510 (42%), Gaps = 66/510 (12%)
Query: 93 FRVDAETGDVFAIER-LDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVF 151
F + +TG + R LDRE E+ L + D + T + +K+ D NDN P F
Sbjct: 1187 FSIHPKTGLITTTSRKLDREQQDEHILEVTVTDNGSPPK-STIARVIVKILDENDNKPQF 1245
Query: 152 THRLFNASVP-------ESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEY--FAI 202
+ + +P E +A + V A D D+ G +A + Y I G E+ F I
Sbjct: 1246 LQKFYKIRLPEREKPDRERNARREPLYHVIATDKDE---GPNAEISYSIEDGNEHGKFFI 1302
Query: 203 DNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLV--------TLQDINDN 254
+ +++ S Y+I+ G S T + + +L+ I+
Sbjct: 1303 EPKTGVVS---SKRFSAAGEYDILSIKAVDNGRPQKSSTTRLHIEWISKPKPSLEPIS-- 1357
Query: 255 FPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAH 314
F ++ +TF V E V +G + VE P P + I G+Y F ++
Sbjct: 1358 ---FEESFFTFTVMESDPVAHMIGVISVEPPGIP----LWFDITGGNYDSHFDVD----K 1406
Query: 315 NEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQ 373
G I KPLD E Y+ VEATD T + QV I + D D P F
Sbjct: 1407 GTGTIIVAKPLDAEQKSNYNLTVEATDGTTTI---------LTQVFIKVIDTNDHRPQFS 1457
Query: 374 QPFYHFQLKEN-QKKPLIGTVLAMDPDAARHSIGYSIRRTSDK---GQFFRVTKKGDIYN 429
Y + E+ + I + A+D D ++ + Y+++ + D +F G +Y
Sbjct: 1458 TSKYEVVIPEDTAPETEILQISAVDQD-EKNKLIYTLQSSRDPLSLKKFRLDPATGSLYT 1516
Query: 430 EKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEF-AKPYQPKVC 488
++LD E + LTV ++ D P K + ++ + V D ND+AP F A Y+ +V
Sbjct: 1517 SEKLDHEAVHQHTLTVMVRDQD---VPV-KRNFARIVVNVSDTNDHAPWFTASSYKGRVY 1572
Query: 489 ENAVHGQLVLQISAIDKDITPRNVKFKFIL---NTENNFTLTDNHDNTANITVKYGQFDR 545
E+A G +VLQ++A+DKD +N + + + N N+F + D + DR
Sbjct: 1573 ESAAVGSVVLQVTALDKD-KGKNAEVLYSIESGNIGNSFMI----DPVLGSIKTAKELDR 1627
Query: 546 EHTKVHFLPVVISDNGMPSRTGTSTLTVAV 575
+ + L V +D G P + +++ + V
Sbjct: 1628 SNQAEYDLMVKATDKGSPPMSEITSVRIFV 1657
Score = 110 bits (274), Expect = 7e-24
Identities = 139/540 (25%), Positives = 227/540 (42%), Gaps = 74/540 (13%)
Query: 93 FRVDAETGDVFAIERLDRENISE-YHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVF 151
F +D TG V E LD E + Y L D E TI ++++NDN P+F
Sbjct: 510 FAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITLNNLNDNTPLF 569
Query: 152 THRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE--YFAIDNSGRII 209
++P VG + +V+A+DAD+ + V YQI G E +F+++ + ++
Sbjct: 570 EKINCEGTIPRDLGVGEQITTVSAIDADELQL-----VQYQIEAGNELDFFSLNPNSGVL 624
Query: 210 TITKSLD---REKQARYEIVVEARDAQGLR--------------------GDSGTATVLV 246
++ +SL K + + + + A D + ++G A +L
Sbjct: 625 SLKRSLMDGLGAKVSFHSLRITATDGENFATPLYINITVAASHKLVNLQCEETGVAKMLA 684
Query: 247 -------------TLQDI-------NDNFPFFTQTKYTFV-VPEDTRVGTSVGSLFVEDP 285
++DI N + P F T T + V E+ VG+SV + D
Sbjct: 685 EKLLQANKLHNQGEVEDIFFDSHSVNAHIPQFRSTLPTGIQVKENQPVGSSVIFMNSTDL 744
Query: 286 DEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTID 345
D N Y++ G+ F I+ G++K + PLD E +Y+ + D I
Sbjct: 745 DTGFNGKLVYAVSGGNEDSCFMIDM----ETGMLKILSPLDRETTDKYTLNITVYDLGIP 800
Query: 346 LRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQK-KPLIGTVLAMDPDAARHS 404
+ A R ++ + D PP F Q Y ++ E+++ I V A D D +
Sbjct: 801 QK-----AAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKDLGPNG 855
Query: 405 -IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIV 463
+ YSI +D VT G + + LDRE+ ++L +EA+ D S V
Sbjct: 856 HVTYSIVTDTDTFSIDSVT--GVVNIARPLDRELQHEHSLKIEAR--DQAREEPQLFSTV 911
Query: 464 QVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQISAIDKDI-TPRNVKFKFILNTE 521
V + + D NDN P F P Y+ KV E+ G +++ + A D D+ V++ + + E
Sbjct: 912 VVKVSLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGE 971
Query: 522 NNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMP-SRTGTSTLTVAVCKCNE 580
NF + D + Q D E +V+ L V D G P S + T + V V NE
Sbjct: 972 GNFDV----DKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLSSTCYVEVEVVDVNE 1027
Score = 103 bits (256), Expect = 8e-22
Identities = 119/485 (24%), Positives = 213/485 (43%), Gaps = 40/485 (8%)
Query: 108 LDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVG 167
L+RE Y L ++K+T N+E + ++V D ND P+F+ ++ S+PE++A+
Sbjct: 108 LNREVKDHYTLIVKALEKNT--NVEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
Query: 168 TSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVV 227
TS+ V+A DAD +G + Y + FAI + +I +T LD + YE+ +
Sbjct: 166 TSIARVSATDAD---IGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYLETKLYEMEI 222
Query: 228 EARD----AQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVE 283
A D G G S A + V ++ N+ P T + P + + + V+
Sbjct: 223 LAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLS---PSELDRDPAYAIVTVD 279
Query: 284 DPDEPQN-RMTKYSILRGDYQDAF-TIETNPAHNEGIIKPMKPLDYE-YIQQYSFIVEAT 340
D D+ N + SI+ GD F T+ + P E +K + +D++ + Y+ ++A
Sbjct: 280 DCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQAK 339
Query: 341 DPTIDLRYMSPPAGNRAQVIINITDVD---EPPIFQQPFYHFQLKENQKKPLIGTVLAMD 397
D +PP + +V I++T P F++ Y ++ E P V+ +
Sbjct: 340 DKG------TPPQFSSVKV-IHVTSPQFKAGPVKFEKDVYRAEISE--FAPPNTPVVMVK 390
Query: 398 PDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPT 457
A + Y + T K +F G I + + R+ + L V T +
Sbjct: 391 AIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEV---------TTS 441
Query: 458 GKESIVQVHIEVLDENDNAPEFAK-PYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKF 516
+++ +V ++VL N N PEF + Y+ EN G V+ +SA+D D N +
Sbjct: 442 DRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPD-EGENGYVTY 500
Query: 517 ILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTL-TVAV 575
+ N+ +H A T + ++ +V+ L + SD G+P R L T+ +
Sbjct: 501 SIANLNHVPFAIDHFTGAVSTSENLDYEL-MPRVYTLRIRASDWGLPYRREVEVLATITL 559
Query: 576 CKCNE 580
N+
Sbjct: 560 NNLND 564
Score = 99.0 bits (245), Expect = 2e-20
Identities = 111/452 (24%), Positives = 201/452 (44%), Gaps = 39/452 (8%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENL-ETPSSFTIKVHDVNDNWPVF 151
F +D+ TG + + LD E S +H T + D T E ++ T+ V D+ND PVF
Sbjct: 1820 FAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVHVIDINDCPPVF 1879
Query: 152 THRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGK--EYFAIDNSGRII 209
L+ AS+ + G VI+V A DAD + ++Y I +G E F++D +
Sbjct: 1880 AKPLYEASLLLPTYKGVKVITVNATDADSSA---FSQLIYSITEGNIGEKFSMDYKTGAL 1936
Query: 210 TITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPE 269
T+ + + ++RYE+ V A D + +G +V + +++ ++ FTQ Y+ VV E
Sbjct: 1937 TVQNT--TQLRSRYELTVRASDGR----FAGLTSVKINVKESKESHLKFTQDVYSAVVKE 1990
Query: 270 DTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEY 329
++ ++ + P N Y IL D + + + G P D E
Sbjct: 1991 NSTEAETLA--VITAIGNPINEPLFYHILNPDRRFKISRTSGVLSTTG-----TPFDREQ 2043
Query: 330 IQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPL 389
+ + +VE T+ S A +VI+ + + P P+Y + + +
Sbjct: 2044 QEAFDVVVEVTEE----HKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHV 2099
Query: 390 IGTVLAMDPDAARH-SIGYSIRRTSDKGQFFRVTKKGDIYNEKELDRE-VYPWYNLTVEA 447
I V A+D D+ R+ + Y ++ + + F++ G+I +K+ + + + Y +TV A
Sbjct: 2100 IRYVTAVDRDSGRNGEVHYYLK---EHHEHFQIGPLGEISLKKQFELDTLNKEYLVTVVA 2156
Query: 448 KELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQISAIDKD 506
K+ G P ++ V I V+ N P F KP Y ++ E+ V+ + A
Sbjct: 2157 KD---GGNPAFSAEVI-VPITVM--NKAMPVFEKPFYSAEIAESIQVHSPVVHVQA---- 2206
Query: 507 ITPRNVKFKFILNTENNFTLTDNHDNTANITV 538
+P +K + + + F+ + NT I V
Sbjct: 2207 NSPEGLKVFYSITDGDPFSQFTINFNTGVINV 2238
Score = 84.7 bits (208), Expect = 3e-16
Identities = 63/243 (25%), Positives = 113/243 (46%), Gaps = 13/243 (5%)
Query: 71 IKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGEN 130
+K+ + + +Y+ K F ++ TG + +E + R+ + + L D+
Sbjct: 389 VKAIPAYSHLRYVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFELEVTTSDR----- 443
Query: 131 LETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVM 190
+ + +KV N N P FT + A+ E+ +GT+V+S++AVD D+ G++ V
Sbjct: 444 -KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDE---GENGYVT 499
Query: 191 YQILKGKEY-FAIDNSGRIITITKSLDREKQAR-YEIVVEARDAQGLRGDSGTATVLVTL 248
Y I FAID+ ++ +++LD E R Y + + A D +TL
Sbjct: 500 YSIANLNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRASDWGLPYRREVEVLATITL 559
Query: 249 QDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTI 308
++NDN P F + +P D VG + ++ D DE Q + +Y I G+ D F++
Sbjct: 560 NNLNDNTPLFEKINCEGTIPRDLGVGEQITTVSAIDADELQ--LVQYQIEAGNELDFFSL 617
Query: 309 ETN 311
N
Sbjct: 618 NPN 620
Score = 42.7 bits (99), Expect = 0.001
Identities = 108/528 (20%), Positives = 186/528 (35%), Gaps = 78/528 (14%)
Query: 61 NTSLPHHVGKIKSSVSRKNAKYL---LKGEYVGK------VFRVDAETGDVFAIERLDRE 111
+ SLP + I++S++R +A GE+ +F + +G + RLD
Sbjct: 155 SVSLPENTA-IRTSIARVSATDADIGTNGEFYYSFKDRTDMFAIHPTSGVIVLTGRLDYL 213
Query: 112 NISEYHLTAVIVDKDT----GENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVG 167
Y + + D+ + + + T+ + N+ PV T + S +
Sbjct: 214 ETKLYEMEILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLSPSELDRDP-- 271
Query: 168 TSVISVTAVDADDPTVGDHASV------MYQILKGKEYFAIDNSGRIITITKSLDREKQA 221
+ VT D D GD AS+ + Q + F ++ I
Sbjct: 272 -AYAIVTVDDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPF 330
Query: 222 RYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLF 281
Y + ++A+D S + VT F + Y + E T V +
Sbjct: 331 GYNLTLQAKDKGTPPQFSSVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMV- 389
Query: 282 VEDPDEPQNRMTKYSILRGDYQDAFTIETNPA-------HNEGIIKPMKPLDYEYIQQYS 334
+ YS LR + ++ P +N G+I ++P+ + +
Sbjct: 390 --------KAIPAYSHLR------YVFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFE 435
Query: 335 FIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGTVL 394
V +D + + G + PP F Q Y EN P+ TV+
Sbjct: 436 LEVTTSDRKASTKVLVKVLGANSN----------PPEFTQTAYKAAFDENV--PIGTTVM 483
Query: 395 ---AMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPW-YNLTVEAKE 449
A+DPD + + YSI + F G + + LD E+ P Y L + A +
Sbjct: 484 SLSAVDPDEGENGYVTYSIANLNHV-PFAIDHFTGAVSTSENLDYELMPRVYTLRIRASD 542
Query: 450 LDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVH-----GQLVLQISAID 504
G P +E V I + + NDN P F K CE + G+ + +SAID
Sbjct: 543 W---GLPYRREVEVLATITLNNLNDNTPLFEKIN----CEGTIPRDLGVGEQITTVSAID 595
Query: 505 KDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHF 552
D ++ + N + N+ +++K D KV F
Sbjct: 596 AD---ELQLVQYQIEAGNELDFFSLNPNSGVLSLKRSLMDGLGAKVSF 640
>gi|13325064 cadherin EGF LAG seven-pass G-type receptor 2 [Homo
sapiens]
Length = 2923
Score = 191 bits (484), Expect = 3e-48
Identities = 168/533 (31%), Positives = 249/533 (46%), Gaps = 56/533 (10%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
F +DA+TG + + LD E EY L D T++V D+NDN P+F
Sbjct: 447 FYLDAQTGALDVVSPLDYETTKEYTLRVRAQDGGRPPLSNVSGLVTVQVLDINDNAPIFV 506
Query: 153 HRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILK-GKEY-FAIDNSGRIIT 210
F A+V ES +G V+ V A+DAD GD+A + Y++ G ++ F I+N I+
Sbjct: 507 STPFQATVLESVPLGYLVLHVQAIDAD---AGDNARLEYRLAGVGHDFPFTINNGTGWIS 563
Query: 211 ITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPED 270
+ LDRE+ Y VEARD G + +A+V VT+ D+NDN P FTQ +YT + ED
Sbjct: 564 VAAELDREEVDFYSFGVEARD-HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNED 622
Query: 271 TRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYI 330
VGTSV ++ D D + + Y I G+ ++ F+I + G++ PLDY+
Sbjct: 623 AAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGG--GLVSLALPLDYKLE 678
Query: 331 QQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVD-EPPIFQQPFYHFQLKENQKKPL 389
+QY V A+D T + AQ+++N+TD + P+FQ H+ + N+ +P
Sbjct: 679 RQYVLAVTASDGTRQ---------DTAQIVVNVTDANTHRPVFQSS--HYTVNVNEDRPA 727
Query: 390 IGTVLAMDPDAARHSIGYSIRRT---SDKGQFFRV-TKKGDIYNEKELDREVYPWYNLTV 445
TV+ + A G + R T D FR+ G + + ELD E Y L +
Sbjct: 728 GTTVVLIS--ATDEDTGENARITYFMEDSIPQFRIDADTGAVTTQAELDYEDQVSYTLAI 785
Query: 446 EAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQISAID 504
A++ G P K + I V D NDNAP+F + YQ V E+ VLQISA D
Sbjct: 786 TARD---NGIPQ-KSDTTYLEILVNDVNDNAPQFLRDSYQGSVYEDVPPFTSVLQISATD 841
Query: 505 KDITPRNVKFKFILNTENNFTLTDNHD--------NTANITVKYGQFDREHTKVHFLPVV 556
+D LN +T D +T+ I + DRE+ + L
Sbjct: 842 RDSG---------LNGRVFYTFQGGDDGDGDFIVESTSGIVRTLRRLDRENVAQYVLRAY 892
Query: 557 ISDNGMPSRTGTSTLTVAVCKCN------EQGEFTFCEDMAAQVGVSIQAVVA 603
D GMP +TV V N EQ EF + + +G+++ V A
Sbjct: 893 AVDKGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVEENSPIGLAVARVTA 945
Score = 170 bits (431), Expect = 4e-42
Identities = 153/498 (30%), Positives = 229/498 (45%), Gaps = 34/498 (6%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
F +D TG V E LDRE S H+ V ++ TI V D ND+ PVF
Sbjct: 232 FSLDPVTGAVTTAEELDRETKST-HVFRVTAQDHGMPRRSALATLTILVTDTNDHDPVFE 290
Query: 153 HRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGK-----EYFAIDNSGR 207
+ + S+ E+ VG V++V A D D P +A+++Y++L+G E F ID
Sbjct: 291 QQEYKESLRENLEVGYEVLTVRATDGDAPP---NANILYRLLEGSGGSPSEVFEIDPRSG 347
Query: 208 IITITKSLDREKQARYEIVVEARDAQGLRGD-SGTATVLVTLQDINDNFPFFTQTKYTFV 266
+I +DRE+ Y++ VEA D G S TA V ++++D NDN P F++ +Y
Sbjct: 348 VIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQ 407
Query: 267 VPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLD 326
V ED G V + D D+ N + YSI+ G+ + F ++ G + + PLD
Sbjct: 408 VREDVTPGAPVLRVTASDRDKGSNAVVHYSIMSGNARGQFYLDA----QTGALDVVSPLD 463
Query: 327 YEYIQQYSFIVEATDPTIDLRYMSPPAGN-RAQVIINITDV-DEPPIF-QQPFYHFQLKE 383
YE ++Y+ V A D PP N V + + D+ D PIF PF L+
Sbjct: 464 YETTKEYTLRVRAQDGG------RPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLES 517
Query: 384 NQKKPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYN 442
L+ V A+D DA ++ + Y + F G I ELDRE +Y+
Sbjct: 518 VPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYS 577
Query: 443 LTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQIS 501
VEA++ GTP S V + VLD NDN P F +P Y ++ E+A G V+ +S
Sbjct: 578 FGVEARD---HGTPALTAS-ASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVS 633
Query: 502 AIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNG 561
A+D+D NT N F++T + + D + + + L V SD
Sbjct: 634 AVDRDAHSVITYQITSGNTRNRFSITS--QSGGGLVSLALPLDYKLERQYVLAVTASDG- 690
Query: 562 MPSRTGTSTLTVAVCKCN 579
+R T+ + V V N
Sbjct: 691 --TRQDTAQIVVNVTDAN 706
Score = 161 bits (407), Expect = 2e-39
Identities = 140/471 (29%), Positives = 224/471 (47%), Gaps = 29/471 (6%)
Query: 149 PVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQIL--KGKEYFAIDNSG 206
P F + A+VPE+ GT V S+ A+D D+ G M + + ++F++D
Sbjct: 179 PQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFSLDPVT 238
Query: 207 RIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFV 266
+T + LDRE ++ + V A+D G+ S AT+ + + D ND+ P F Q +Y
Sbjct: 239 GAVTTAEELDRETKSTHVFRVTAQD-HGMPRRSALATLTILVTDTNDHDPVFEQQEYKES 297
Query: 267 VPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGD-YQDAFTIETNPAHNEGIIKPMKPL 325
+ E+ VG V ++ D D P N Y +L G + E +P G+I+ P+
Sbjct: 298 LRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDP--RSGVIRTRGPV 355
Query: 326 DYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINI-TDVDEPPIFQQPFYHFQLKEN 384
D E ++ Y VEA+D D P A V +++ D D P F + Y Q++E+
Sbjct: 356 DREEVESYQLTVEASDQGRD----PGPRSTTAAVFLSVEDDNDNAPQFSEKRYVVQVRED 411
Query: 385 --QKKPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWY 441
P++ V A D D ++ + YSI + +GQF+ + G + LD E Y
Sbjct: 412 VTPGAPVL-RVTASDRDKGSNAVVHYSIMSGNARGQFYLDAQTGALDVVSPLDYETTKEY 470
Query: 442 NLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEF-AKPYQPKVCENAVHGQLVLQI 500
L V A++ G P V ++VLD NDNAP F + P+Q V E+ G LVL +
Sbjct: 471 TLRVRAQD---GGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQATVLESVPLGYLVLHV 527
Query: 501 SAIDKDITPRNVKFKF-ILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISD 559
AID D N + ++ + ++F T N + T I+V + DRE + V D
Sbjct: 528 QAIDAD-AGDNARLEYRLAGVGHDFPFTIN-NGTGWISVA-AELDREEVDFYSFGVEARD 584
Query: 560 NGMPSRTGTSTLTVAVCKCNE------QGEFTFCEDMAAQVGVSIQAVVAI 604
+G P+ T +++++V V N+ Q E+T + A VG S+ V A+
Sbjct: 585 HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAV 635
Score = 149 bits (375), Expect = 1e-35
Identities = 150/502 (29%), Positives = 223/502 (44%), Gaps = 41/502 (8%)
Query: 91 KVFRVDAETGDVFAIERLDRENISEYHLTAVIVD--KDTGENLETPSSFTIKVHDVNDNW 148
+VF +D +G + +DRE + Y LT D +D G T + F + V D NDN
Sbjct: 338 EVFEIDPRSGVIRTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAVF-LSVEDDNDNA 396
Query: 149 PVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKG--KEYFAIDNSG 206
P F+ + + V E G V+ VTA D D G +A V Y I+ G + F +D
Sbjct: 397 PQFSEKRYVVQVREDVTPGAPVLRVTASDRDK---GSNAVVHYSIMSGNARGQFYLDAQT 453
Query: 207 RIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQ--DINDNFPFFTQTKYT 264
+ + LD E Y + V A+D G R + LVT+Q DINDN P F T +
Sbjct: 454 GALDVVSPLDYETTKEYTLRVRAQD--GGRPPLSNVSGLVTVQVLDINDNAPIFVSTPFQ 511
Query: 265 FVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKP 324
V E +G V + D D N +Y + + FTI + G I
Sbjct: 512 ATVLESVPLGYLVLHVQAIDADAGDNARLEYRLAGVGHDFPFTIN----NGTGWISVAAE 567
Query: 325 LDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQLKE 383
LD E + YSF VEA D + +P A V + + DV D P F QP Y +L E
Sbjct: 568 LDREEVDFYSFGVEARD------HGTPALTASASVSVTVLDVNDNNPTFTQPEYTVRLNE 621
Query: 384 NQK-KPLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGD--IYNEKELDREVYP 439
+ + TV A+D DA HS I Y I + + +F ++ G + LD ++
Sbjct: 622 DAAVGTSVVTVSAVDRDA--HSVITYQITSGNTRNRFSITSQSGGGLVSLALPLDYKLER 679
Query: 440 WYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEF-AKPYQPKVCENAVHGQLVL 498
Y L V A S GT ++ Q+ + V D N + P F + Y V E+ G V+
Sbjct: 680 QYVLAVTA----SDGT---RQDTAQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVV 732
Query: 499 QISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVIS 558
ISA D+D T N + + + E++ +T +T + + D E + L +
Sbjct: 733 LISATDED-TGENARITYFM--EDSIPQFRIDADTGAVTTQ-AELDYEDQVSYTLAITAR 788
Query: 559 DNGMPSRTGTSTLTVAVCKCNE 580
DNG+P ++ T+ L + V N+
Sbjct: 789 DNGIPQKSDTTYLEILVNDVND 810
Score = 129 bits (325), Expect = 8e-30
Identities = 132/488 (27%), Positives = 207/488 (42%), Gaps = 43/488 (8%)
Query: 135 SSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQIL 194
+ + V D N + PVF + +V E GT+V+ ++A D D G++A + Y +
Sbjct: 696 AQIVVNVTDANTHRPVFQSSHYTVNVNEDRPAGTTVVLISATDED---TGENARITYFME 752
Query: 195 KGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDN 254
F ID +T LD E Q Y + + ARD G+ S T + + + D+NDN
Sbjct: 753 DSIPQFRIDADTGAVTTQAELDYEDQVSYTLAITARD-NGIPQKSDTTYLEILVNDVNDN 811
Query: 255 FPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDA-FTIETNPA 313
P F + Y V ED TSV + D D N Y+ GD D F +E+
Sbjct: 812 APQFLRDSYQGSVYEDVPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVEST-- 869
Query: 314 HNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIF 372
GI++ ++ LD E + QY A D + PPA +V + + DV D PP+F
Sbjct: 870 --SGIVRTLRRLDRENVAQYVLRAYAVDKGM------PPARTPMEVTVTVLDVNDNPPVF 921
Query: 373 QQPFYHFQLKENQKKPL-IGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNE 430
+Q + ++EN L + V A DPD ++ I Y I + F G++
Sbjct: 922 EQDEFDVFVEENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDIFSGELTAL 981
Query: 431 KELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAP---EFAKPYQPKV 487
+LD E P Y L ++A T VH+ +LD NDN P F + V
Sbjct: 982 VDLDYEDRPEYVLVIQATSAPLVSRAT-------VHVRLLDRNDNPPVLGNFEILFNNYV 1034
Query: 488 C--ENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDR 545
++ G + ++ A D DI+ ++ + F E + L + ++ D
Sbjct: 1035 TNRSSSFPGGAIGRVPAHDPDISD-SLTYSFERGNELSLVLLNASTGELKLS---RALDN 1090
Query: 546 EHTKVHFLPVVISDNGMPSRTGTSTLTVAVC--KCNEQGEFTFCEDMAAQ------VGVS 597
+ V++SD G+ S T L V + + EDM+ + +G+
Sbjct: 1091 NRPLEAIMSVLVSD-GVHSVTAQCALRVTIITDEMLTHSITLRLEDMSPERFLSPLLGLF 1149
Query: 598 IQAVVAIL 605
IQAV A L
Sbjct: 1150 IQAVAATL 1157
Score = 128 bits (321), Expect = 2e-29
Identities = 130/437 (29%), Positives = 197/437 (45%), Gaps = 39/437 (8%)
Query: 81 KYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIK 140
+Y L G F ++ TG + LDRE + Y D T L +S ++
Sbjct: 541 EYRLAGVGHDFPFTINNGTGWISVAAELDREEVDFYSFGVEARDHGTPA-LTASASVSVT 599
Query: 141 VHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKG--KE 198
V DVNDN P FT + + E +AVGTSV++V+AVD D H+ + YQI G +
Sbjct: 600 VLDVNDNNPTFTQPEYTVRLNEDAAVGTSVVTVSAVDRDA-----HSVITYQITSGNTRN 654
Query: 199 YFAI--DNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFP 256
F+I + G ++++ LD + + +Y + V A D G R D TA ++V + D N + P
Sbjct: 655 RFSITSQSGGGLVSLALPLDYKLERQYVLAVTASD--GTRQD--TAQIVVNVTDANTHRP 710
Query: 257 FFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNE 316
F + YT V ED GT+V + D D +N Y D F I+ +
Sbjct: 711 VFQSSHYTVNVNEDRPAGTTVVLISATDEDTGENARITY--FMEDSIPQFRIDA----DT 764
Query: 317 GIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQP 375
G + LDYE Y+ + A D I P + + I + DV D P F +
Sbjct: 765 GAVTTQAELDYEDQVSYTLAITARDNGI------PQKSDTTYLEILVNDVNDNAPQFLRD 818
Query: 376 FYHFQLKENQKKPLIGTVL---AMDPDAARHS-IGYSIRRTSD-KGQFFRVTKKGDIYNE 430
Y + E+ P +VL A D D+ + + Y+ + D G F + G +
Sbjct: 819 SYQGSVYED--VPPFTSVLQISATDRDSGLNGRVFYTFQGGDDGDGDFIVESTSGIVRTL 876
Query: 431 KELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAK-PYQPKVCE 489
+ LDRE Y L A + G P + + ++V + VLD NDN P F + + V E
Sbjct: 877 RRLDRENVAQYVLRAYAVD---KGMPPAR-TPMEVTVTVLDVNDNPPVFEQDEFDVFVEE 932
Query: 490 NAVHGQLVLQISAIDKD 506
N+ G V +++A D D
Sbjct: 933 NSPIGLAVARVTATDPD 949
Score = 127 bits (319), Expect = 4e-29
Identities = 105/352 (29%), Positives = 166/352 (47%), Gaps = 30/352 (8%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFT-IKVHDVNDNWPVF 151
FR+DA+TG V LD E+ Y T I +D G ++ +++ I V+DVNDN P F
Sbjct: 758 FRIDADTGAVTTQAELDYEDQVSY--TLAITARDNGIPQKSDTTYLEILVNDVNDNAPQF 815
Query: 152 THRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEY---FAIDNSGRI 208
+ SV E TSV+ ++A D D G + V Y G + F ++++ I
Sbjct: 816 LRDSYQGSVYEDVPPFTSVLQISATDRDS---GLNGRVFYTFQGGDDGDGDFIVESTSGI 872
Query: 209 ITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVP 268
+ + LDRE A+Y + A D +G+ V VT+ D+NDN P F Q ++ V
Sbjct: 873 VRTLRRLDRENVAQYVLRAYAVD-KGMPPARTPMEVTVTVLDVNDNPPVFEQDEFDVFVE 931
Query: 269 EDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYE 328
E++ +G +V + DPDE N Y I+ G+ + F ++ G + + LDYE
Sbjct: 932 ENSPIGLAVARVTATDPDEGTNAQIMYQIVEGNIPEVFQLDI----FSGELTALVDLDYE 987
Query: 329 YIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITD-VDEPPI---FQQPFYHFQLKEN 384
+Y +++AT S P +RA V + + D D PP+ F+ F ++ +
Sbjct: 988 DRPEYVLVIQAT---------SAPLVSRATVHVRLLDRNDNPPVLGNFEILFNNYVTNRS 1038
Query: 385 QKKP--LIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELD 434
P IG V A DPD + S+ YS R ++ G++ + LD
Sbjct: 1039 SSFPGGAIGRVPAHDPDIS-DSLTYSFERGNELSLVLLNASTGELKLSRALD 1089
Score = 58.9 bits (141), Expect = 2e-08
Identities = 59/216 (27%), Positives = 94/216 (43%), Gaps = 11/216 (5%)
Query: 365 DVDEPPIFQQPFYHFQLKENQKKPL-IGTVLAMDPD---AARHSIGYSIRRTSDKGQFFR 420
+V+ P FQ P Y + ENQ + ++ A+DPD A R S QFF
Sbjct: 174 NVNTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAGRLEYTMDALFDSRSNQFFS 233
Query: 421 VTK-KGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEF 479
+ G + +ELDRE + V A++ G P + ++ + I V D ND+ P F
Sbjct: 234 LDPVTGAVTTAEELDRETKSTHVFRVTAQD---HGMPR-RSALATLTILVTDTNDHDPVF 289
Query: 480 -AKPYQPKVCENAVHGQLVLQISAIDKDITPR-NVKFKFILNTENNFTLTDNHDNTANIT 537
+ Y+ + EN G VL + A D D P N+ ++ + + + + D + +
Sbjct: 290 EQQEYKESLRENLEVGYEVLTVRATDGDAPPNANILYRLLEGSGGSPSEVFEIDPRSGVI 349
Query: 538 VKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTV 573
G DRE + + L V SD G ++T V
Sbjct: 350 RTRGPVDREEVESYQLTVEASDQGRDPGPRSTTAAV 385
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/110 (28%), Positives = 48/110 (43%), Gaps = 4/110 (3%)
Query: 474 DNAPEFAKP-YQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNT--ENNFTLTDNH 530
+ AP+F P YQ V EN G V + AID D + ++ ++ ++ +
Sbjct: 176 NTAPQFQPPSYQATVPENQPAGTPVASLRAIDPDEGEAG-RLEYTMDALFDSRSNQFFSL 234
Query: 531 DNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 580
D + DRE H V D+GMP R+ +TLT+ V N+
Sbjct: 235 DPVTGAVTTAEELDRETKSTHVFRVTAQDHGMPRRSALATLTILVTDTND 284
Score = 40.4 bits (93), Expect = 0.006
Identities = 41/164 (25%), Positives = 80/164 (48%), Gaps = 13/164 (7%)
Query: 89 VGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNW 148
+ +VF++D +G++ A+ LD E+ EY V+V + T L + ++ +++ D NDN
Sbjct: 965 IPEVFQLDIFSGELTALVDLDYEDRPEY----VLVIQATSAPLVSRATVHVRLLDRNDNP 1020
Query: 149 PVFTH--RLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE--YFAIDN 204
PV + LFN V S+ ++ V A DP + D S+ Y +G E ++
Sbjct: 1021 PVLGNFEILFNNYVTNRSSSFPGG-AIGRVPAHDPDISD--SLTYSFERGNELSLVLLNA 1077
Query: 205 SGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTL 248
S + ++++LD + E ++ + G+ + + VT+
Sbjct: 1078 STGELKLSRALDNNRP--LEAIMSVLVSDGVHSVTAQCALRVTI 1119
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 186 bits (471), Expect = 9e-47
Identities = 219/795 (27%), Positives = 344/795 (43%), Gaps = 99/795 (12%)
Query: 43 RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRK-NAKYLLKGEYVGK----VFRVDA 97
RR KR W + E P + +++S ++ Y + G V K +F ++
Sbjct: 131 RRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIER 190
Query: 98 ETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFN 157
+TG++F +DRE + L A D G + + P I+V D NDN PVFT ++N
Sbjct: 191 DTGNLFCTRPVDREEYDVFDLIAYASTAD-GYSADLPLPLPIRVEDENDNHPVFTEAIYN 249
Query: 158 ASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQIL----KGKEYFAI-DNSGRIITIT 212
V ESS GT+V V A D D+P H + Y IL + F++ ++G I T++
Sbjct: 250 FEVLESSRPGTTVGVVCATDRDEPDT-MHTRLKYSILQQTPRSPGLFSVHPSTGVITTVS 308
Query: 213 KSLDREKQARYEIVVEARDAQG-LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDT 271
LDRE +Y ++++ +D G G GT+T ++T+ D NDN P F Q Y V E+
Sbjct: 309 HYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFV-EEN 367
Query: 272 RVGTSVGSLFVEDPD--EPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEY 329
+ + +ED D N ++IL+G+ F I T+ NEG++ +KPL+YE
Sbjct: 368 AFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427
Query: 330 IQQYSFIVEATDPTIDLRYM-SPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKEN-QKK 387
+Q + + + R + A NRA V +++ D+DE P + ++KEN
Sbjct: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487
Query: 388 PLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTK-KGDIYNEKELDREV----YPWYN 442
I A DP+ R+ G ++ D + + + G I K LDREV YN
Sbjct: 488 SKINGYKAYDPE-NRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYN 546
Query: 443 LTVEAKELDS---TGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQ 499
+TV A + D TGT + V+IE D NDN PE + Y +C+ +
Sbjct: 547 ITVLAIDKDDRSCTGT-------LAVNIE--DVNDNPPEILQEY-VVICKPKMG---YTD 593
Query: 500 ISAIDKDITPRNVKFKFIL-NTENN----FTLTDNHDNTANITVKYGQFDREHTKVHFLP 554
I A+D D F F L NT ++LT +D A ++ + +E+T +P
Sbjct: 594 ILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYT----IP 649
Query: 555 VVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSI--QAVVAILLCI-LTI 611
+ + D + T L V +C+C T C + GV + A++AILL I L
Sbjct: 650 ITVKDRA--GQAATKLLRVNLCECTHP---TQCRATSRSTGVILGKWAILAILLGIALLF 704
Query: 612 TVITLLIFLRRRLRKQARAHGKSVPE--IHEQLVTYDEEGGGE---------MDTTSYDV 660
+V+ L+ GK PE + L+ + E G+ M T+ +
Sbjct: 705 SVLLTLV-----CGVFGATKGKRFPEDLAQQNLIISNTEAPGDDRVCSANGFMTQTTNNS 759
Query: 661 S------VLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHA-PGAHGGP----------G 703
S + + ++ GG + +L + H GG
Sbjct: 760 SQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCRYTYS 819
Query: 704 EMAAMIEVKKDEADH-----DGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVD-Y 757
E + + + E H + P D + Y YEG S A S+G S + D
Sbjct: 820 EWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPA---GSVGCCSEKQEEDGL 876
Query: 758 DFLNDWGPRFKMLAE 772
DFLN+ P+F LAE
Sbjct: 877 DFLNNLEPKFITLAE 891
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 185 bits (469), Expect = 2e-46
Identities = 177/606 (29%), Positives = 280/606 (46%), Gaps = 56/606 (9%)
Query: 43 RRQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVSRK-NAKYLLKGEYVGK----VFRVDA 97
RR KR W + E P + +++S ++ Y + G V K +F ++
Sbjct: 131 RRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQNYTVFYSISGRGVDKEPLNLFYIER 190
Query: 98 ETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFN 157
+TG++F +DRE + L A D G + + P I+V D NDN PVFT ++N
Sbjct: 191 DTGNLFCTRPVDREEYDVFDLIAYASTAD-GYSADLPLPLPIRVEDENDNHPVFTEAIYN 249
Query: 158 ASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQIL----KGKEYFAI-DNSGRIITIT 212
V ESS GT+V V A D D+P H + Y IL + F++ ++G I T++
Sbjct: 250 FEVLESSRPGTTVGVVCATDRDEPDT-MHTRLKYSILQQTPRSPGLFSVHPSTGVITTVS 308
Query: 213 KSLDREKQARYEIVVEARDAQG-LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDT 271
LDRE +Y ++++ +D G G GT+T ++T+ D NDN P F Q Y V E+
Sbjct: 309 HYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAYEAFV-EEN 367
Query: 272 RVGTSVGSLFVEDPD--EPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEY 329
+ + +ED D N ++IL+G+ F I T+ NEG++ +KPL+YE
Sbjct: 368 AFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSVVKPLNYEE 427
Query: 330 IQQYSFIVEATDPTIDLRYM-SPPAGNRAQVIINITDVDEPPIFQQPFYHFQLKEN-QKK 387
+Q + + + R + A NRA V +++ D+DE P + ++KEN
Sbjct: 428 NRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVRIKENLAVG 487
Query: 388 PLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTK-KGDIYNEKELDREV----YPWYN 442
I A DP+ R+ G ++ D + + + G I K LDREV YN
Sbjct: 488 SKINGYKAYDPE-NRNGNGLRYKKLHDPKGWITIDEISGSIITSKILDREVETPKNELYN 546
Query: 443 LTVEAKELDS---TGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQ 499
+TV A + D TGT + V+IE D NDN PE + Y +C+ +
Sbjct: 547 ITVLAIDKDDRSCTGT-------LAVNIE--DVNDNPPEILQEY-VVICKPKMG---YTD 593
Query: 500 ISAIDKDITPRNVKFKFIL-NTENN----FTLTDNHDNTANITVKYGQFDREHTKVHFLP 554
I A+D D F F L NT ++LT +D A ++ + +E+T +P
Sbjct: 594 ILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLTKVNDTAARLSYQKNAGFQEYT----IP 649
Query: 555 VVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSI--QAVVAILLCILTIT 612
+ + D + T L V +C+C T C + GV + A++AILL I +
Sbjct: 650 ITVKDRA--GQAATKLLRVNLCECTHP---TQCRATSRSTGVILGKWAILAILLGIALLF 704
Query: 613 VITLLI 618
+ L +
Sbjct: 705 SVLLTL 710
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 182 bits (461), Expect = 1e-45
Identities = 170/592 (28%), Positives = 274/592 (46%), Gaps = 39/592 (6%)
Query: 1 MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIW--NQMHIDE 58
+Q +L GACL L+ V A+ + A P + + ++ + + +
Sbjct: 1690 IQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPVFPTDMLDLTV 1749
Query: 59 EKNTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKV---FRVDAETGDVFAIERLDRENISE 115
E+N + ++ + + + A L+ + FR+D E+GD+ A RLDRE S+
Sbjct: 1750 EENIGDGSKIMQLTAMDADEGANALVTYTIISGADDSFRIDPESGDLIATRRLDRERRSK 1809
Query: 116 YHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTA 175
Y L +V D G + I V DVND+ P F+ +++ +PE + G+ V ++ A
Sbjct: 1810 YSL---LVRADDGLQ-SSDMRINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILA 1865
Query: 176 VDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGL 235
D D G+ ++ + + +F +G + +T+ LD E Q Y + V A D G
Sbjct: 1866 TDDDSGVNGEITYIVNEDDEDGIFFLNPITG-VFNLTRLLDYEVQQYYILTVRAEDGGG- 1923
Query: 236 RGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKY 295
T V + D+NDN P F+ Y+ + E+ VG++V V D D+ N Y
Sbjct: 1924 --QFTTIRVYFNILDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTY 1981
Query: 296 SILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATD-PTIDLRYMSPPAG 354
SI GD FT++ N G++K +K LD E Y+ +V+ D P I +
Sbjct: 1982 SIASGDSLGQFTVDKN-----GVLKVLKALDRESQSFYNLVVQVHDLPQIPASRFT---- 2032
Query: 355 NRAQVIINITDV-DEPPIFQQPFYHFQLKENQKKPLIGTVLAMDPDAARHS-IGYSIRRT 412
+ AQV I + DV D PP F P + + ++ A DPD+ +S I Y++
Sbjct: 2033 STAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTL--L 2090
Query: 413 SDKGQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLD 471
+ G F + T G++ ELDRE Y LTV A + G P+ S +V + VLD
Sbjct: 2091 NPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATD---KGQPS-LSSSTEVVVMVLD 2146
Query: 472 ENDNAPEFAKP-YQPKVCENAVHGQLVLQISAIDKDI-TPRNVKFKFIL-NTENNFTLTD 528
NDN P FA+ Y+ ++ EN + G ++Q+ A D D T V++ + NT F +
Sbjct: 2147 INDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVNGNTNQEFRI-- 2204
Query: 529 NHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 580
D+ DRE T + L V +D G RT TST+++ + N+
Sbjct: 2205 --DSVTGAITVAKPLDREKTPTYHLTVQATDRGSTPRTDTSTVSIVLLDIND 2254
Score = 172 bits (436), Expect = 1e-42
Identities = 147/492 (29%), Positives = 224/492 (45%), Gaps = 34/492 (6%)
Query: 108 LDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVG 167
LDRE +Y L + DK + + V D+NDN PVF + A VPE + VG
Sbjct: 208 LDREVTPQYQLLVEVEDKGEPKR-RGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVG 266
Query: 168 TSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVV 227
+SV+ V A DAD+ G +A + Y++ F +D +IT+ + LD E + +Y + V
Sbjct: 267 SSVLQVAAADADE---GTNADIRYRLQDEGTPFQMDPETGLITVREPLDFEARRQYSLTV 323
Query: 228 EARDAQGLRGDSGTATVLVTLQDINDN-----FPFFTQTKYTFVVPEDTRVGTSVGSLFV 282
+A D +G+ +G A L+ L D+NDN F +F T V E+ +VGT V L V
Sbjct: 324 QAMD-RGVPSLTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTV 382
Query: 283 EDPDEP-QNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATD 341
D D P N IL G+ Q F ++++ N +IK LD E I Y+ V +D
Sbjct: 383 TDADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSD 442
Query: 342 PTIDLRYMSPPA------GNRAQVIINITDV-DEPPIFQQPFYHFQLKENQKK-PLIGTV 393
Y +PP + A ++I + D+ D PP+F Q Y L E + +
Sbjct: 443 -----NYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGI 497
Query: 394 LAMDPDAARH-SIGYSIRRTSDKGQFFRVTKKGDIYNEKE--LDREVYPWYNLTVEAKEL 450
A D D+ + ++ YSI + G F G + LDRE+ L + A+
Sbjct: 498 SATDGDSGLNANLRYSIVSGNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISAR-- 555
Query: 451 DSTGTPTGKESIVQVHIEVLDENDNAPEFAKP--YQPKVCENAVHGQLVLQISAIDKDIT 508
D P K S Q+ + +LD ND P F++P Y V ENA G +L + A D D+
Sbjct: 556 DQGVHP--KVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELLMLRATDGDLG 613
Query: 509 PRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGT 568
N +F L + D + DRE + L V+ +D G P ++
Sbjct: 614 D-NGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQSSM 672
Query: 569 STLTVAVCKCNE 580
+ + V++ N+
Sbjct: 673 ARINVSLLDIND 684
Score = 164 bits (416), Expect = 2e-40
Identities = 151/506 (29%), Positives = 231/506 (45%), Gaps = 25/506 (4%)
Query: 82 YLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKV 141
++ ++GK F++D +TG + L + + +T DK L + ++ I V
Sbjct: 3022 FISNDNHLGK-FKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPP-LSSQATVHITV 3079
Query: 142 HDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKE--Y 199
+ N + P F+ +A++PES ++G+ V +V+A D D G + Y I G E
Sbjct: 3080 TEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNG---LIKYSISSGNEEGI 3136
Query: 200 FAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFT 259
FAI++S I+T+ K+LD E ++E+ + A D G +G +V V + D+NDN P F
Sbjct: 3137 FAINSSTGILTLAKALDYELCQKHEMTISAIDG-GWVARTGYCSVTVNVIDVNDNSPVFL 3195
Query: 260 QTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGII 319
Y V E+ GT+V L D D N + Y++ D D F I+ N G+I
Sbjct: 3196 SDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSD-SDLFVIDPNT----GVI 3250
Query: 320 KPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDE-PPIFQQPFYH 378
LD+E Q Y V+A + + R + A V I + +E P F Y+
Sbjct: 3251 TTQGFLDFETKQSYHLTVKAFNVPDEERC------SFATVNIQLKGTNEYVPRFVSKLYY 3304
Query: 379 FQLKENQKK-PLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDRE 436
F++ E K ++G V A D D + Y I S K F K G IY LDRE
Sbjct: 3305 FEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDRE 3364
Query: 437 VYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQL 496
+L V AK S E V V++ VLD ND Y ++ E G
Sbjct: 3365 KEERVSLKVLAKNFGSIRGADIDE--VTVNVTVLDANDPPIFTLNIYSVQISEGVPIGTH 3422
Query: 497 VLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVV 556
V +SA D D P +F + + + N + T ITV + DRE ++ L V+
Sbjct: 3423 VTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVT-AELDRETLPIYNLSVL 3481
Query: 557 ISDNGMPSRTGTSTLTVAVCKCNEQG 582
D+G PS TG+++L V + N+ G
Sbjct: 3482 AVDSGTPSATGSASLLVTLEDINDNG 3507
Score = 162 bits (411), Expect = 9e-40
Identities = 150/504 (29%), Positives = 230/504 (45%), Gaps = 28/504 (5%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
F ++ TG++ ++ LDRE +S Y LT DK + T I + D NDN P F+
Sbjct: 2716 FSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQ-STSVKVMINILDENDNAPRFS 2774
Query: 153 HRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITIT 212
++F+A VPE+S +G +V VT D D +G +A Y I+ F I+ S I I+
Sbjct: 2775 -QIFSAHVPENSPLGYTVTRVTTSDED---IGINAISRYSIMDASLPFTINPSTGDIVIS 2830
Query: 213 KSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTR 272
+ L+RE RY I V A D+ G + + V + + DINDN P F++T Y PE T
Sbjct: 2831 RPLNREDTDRYRIRVSAHDS----GWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTE 2886
Query: 273 VGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYE--YI 330
+G+ V +F DPDE N Y I T N+ I+K + I
Sbjct: 2887 IGSKVTQVFATDPDEGSNGQVFYFIKSQSEYFRINATTGEIFNKQILKYQNVTGFSNVNI 2946
Query: 331 QQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQLKENQK--K 387
++SFIV ++D P + V INI D D P F + Y + +N K
Sbjct: 2947 NRHSFIVTSSDRG------KPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGT 3000
Query: 388 PLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVE 446
LI D D +S + Y I + G+F G I L ++ + +TV
Sbjct: 3001 KLIRVTAIDDKDFGLNSEVEYFISNDNHLGKFKLDNDTGWISVASSLISDLNQNFFITVT 3060
Query: 447 AKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPY-QPKVCENAVHGQLVLQISAIDK 505
AK+ G P S VHI V +EN + PEF++ + + E+ G +V +SA D+
Sbjct: 3061 AKD---KGNPP-LSSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDR 3116
Query: 506 DITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSR 565
D N K+ +++ N + + +T +T+ D E + H + + D G +R
Sbjct: 3117 D-AAMNGLIKYSISSGNEEGIFAINSSTGILTLAKA-LDYELCQKHEMTISAIDGGWVAR 3174
Query: 566 TGTSTLTVAVCKCNEQGEFTFCED 589
TG ++TV V N+ +D
Sbjct: 3175 TGYCSVTVNVIDVNDNSPVFLSDD 3198
Score = 160 bits (405), Expect = 4e-39
Identities = 149/504 (29%), Positives = 233/504 (46%), Gaps = 42/504 (8%)
Query: 92 VFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVF 151
+F ++ + G + + LD + Y + + D + L + T+ VHDVNDN PVF
Sbjct: 939 LFAINEKNGTISLLGPLD-VHAGSYQIEILASDMGVPQ-LSSSVILTVYVHDVNDNSPVF 996
Query: 152 THRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGK--EYFAIDNSGRII 209
+ ++ ES V + V A D D G + + Y I +G + F I G++
Sbjct: 997 DQLSYEVTLSESEPVNSRFFKVQASDKDS---GANGEIAYTIAEGNTGDAFGIFPDGQLY 1053
Query: 210 TITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPE 269
I LDRE Q RY ++V A D + + S T V V L+D+NDN P F T YTF E
Sbjct: 1054 -IKSELDRELQDRYVLMVVASD-RAVEPLSATVNVTVILEDVNDNRPLFNSTNYTFYFEE 1111
Query: 270 DTRVGTSVGSLFVEDPDEPQNRMTKYS--ILRGDYQ-DAFTIETNPAHNEGIIKPMKPLD 326
+ R G+ VG + D D N +YS +++ D++ A + E H D
Sbjct: 1112 EQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQPDFELHAISGEITNTHQ---------FD 1162
Query: 327 YEYIQQ------YSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHF 379
E + + +SF V ATD I P ++A V + + D+ D P F + FY
Sbjct: 1163 RESLMRRRGTAVFSFTVIATDQGI-----PQPLKDQATVHVYMKDINDNAPKFLKDFYQA 1217
Query: 380 QLKENQKK-PLIGTVLAMDPDAARHS-IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREV 437
+ E+ + V A D D + I YSI + +++ QF + G + +LD E
Sbjct: 1218 TISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQFAIDSTSGQVTLIGKLDYEA 1277
Query: 438 YPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAK-PYQPKVCENAVHGQL 496
P Y+L ++A +DS P S ++I++LDENDN P F K V EN G+L
Sbjct: 1278 TPAYSLVIQA--VDSGTIPL--NSTCTLNIDILDENDNTPSFPKSTLFVDVLENMRIGEL 1333
Query: 497 VLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVV 556
V ++A D D + I T N+ T + + NT +I + + D E ++ L +
Sbjct: 1334 VSSVTATDSDSGDNADLYYSITGTNNHGTFSIS-PNTGSIFLA-KKLDFETQSLYKLNIT 1391
Query: 557 ISDNGMPSRTGTSTLTVAVCKCNE 580
D G P R+ T ++ + V N+
Sbjct: 1392 AKDQGRPPRSSTMSVVIHVRDFND 1415
Score = 157 bits (398), Expect = 3e-38
Identities = 154/525 (29%), Positives = 241/525 (45%), Gaps = 61/525 (11%)
Query: 92 VFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVF 151
+F +++ TG ++ +DRE++ + V++ P+ + V D+NDN PVF
Sbjct: 80 LFAINSSTGALYTTSTIDRESLPSDVINLVVLSSAP----TYPTEVRVLVRDLNDNAPVF 135
Query: 152 THRLFNASVPESSAVGTSVISVTAVDADDPTVG-DHASVMYQILKGKE--YFAID----- 203
+ E S+ G VI TA D+D + G DH S Y+I++G E F +D
Sbjct: 136 PDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRS--YRIIRGNEAGRFRLDITLNP 193
Query: 204 -NSGRIITITK--SLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQ 260
G + + LDRE +Y+++VE D +G G V VT+QDINDN P F
Sbjct: 194 SGEGAFLHLVSKGGLDREVTPQYQLLVEVED-KGEPKRRGYLQVNVTVQDINDNPPVFGS 252
Query: 261 TKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFT-IETNPAHNEGII 319
+ Y VPED VG+SV + D DE N +Y + QD T + +P G+I
Sbjct: 253 SHYQAGVPEDAVVGSSVLQVAAADADEGTNADIRYRL-----QDEGTPFQMDP--ETGLI 305
Query: 320 KPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFY- 377
+PLD+E +QYS V+A D + P RA+ +I + DV D P+ + ++
Sbjct: 306 TVREPLDFEARRQYSLTVQAMDRGV------PSLTGRAEALIQLLDVNDNDPVVKFRYFP 359
Query: 378 ----HFQLKENQKKPLIGTVLAM------DPDAARHSIGYSIRRTSDKGQF----FRVTK 423
+ + EN + +GTV+A+ D AA +I I +++ F +V
Sbjct: 360 ATSRYASVDENAQ---VGTVVALLTVTDADSPAANGNISVQILGGNEQRHFEVQSSKVPN 416
Query: 424 KGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTG-----KESIVQVHIEVLDENDNAPE 478
I LDRE P YNLTV D+ G P G + S+ + I V D ND+ P
Sbjct: 417 LSLIKVASALDRERIPSYNLTVSVS--DNYGAPPGAAVQARSSVASLVIFVNDINDHPPV 474
Query: 479 FAKP-YQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANIT 537
F++ Y+ + E A G V ISA D D + N ++ + + N +++ +T
Sbjct: 475 FSQQVYRVNLSEEAPPGSYVSGISATDGD-SGLNANLRYSIVSGNGLGWFHISEHSGLVT 533
Query: 538 V-KYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQ 581
G DRE L + D G+ + + L V + N++
Sbjct: 534 TGSSGGLDRELASQIVLNISARDQGVHPKVSYAQLVVTLLDVNDE 578
Score = 155 bits (393), Expect = 1e-37
Identities = 147/536 (27%), Positives = 231/536 (43%), Gaps = 44/536 (8%)
Query: 60 KNTSLPHHVGKIKSSVS--RKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYH 117
+N +L +HVG + +S N YL+ +F ++ TG + +DRE S Y
Sbjct: 804 ENVALGYHVGSVSASTMDLNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQ 863
Query: 118 LTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVD 177
L V +G + + I V D+NDN P F + + +V E+ G S+ AVD
Sbjct: 864 LKVVA----SGGTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVD 919
Query: 178 ADDPTVGDHASVMYQILKG-KEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLR 236
D+ G + V+Y + + K FAI+ I++ LD Y+I + A D G+
Sbjct: 920 PDE---GVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLD-VHAGSYQIEILASD-MGVP 974
Query: 237 GDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYS 296
S + + V + D+NDN P F Q Y + E V + + D D N Y+
Sbjct: 975 QLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYT 1034
Query: 297 ILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNR 356
I G+ DAF I +G + LD E +Y +V A+D ++ P
Sbjct: 1035 IAEGNTGDAFGI-----FPDGQLYIKSELDRELQDRYVLMVVASDRAVE------PLSAT 1083
Query: 357 AQVIINITDV-DEPPIFQQPFYHFQLKENQKK-PLIGTVLAMDPD-AARHSIGYSIRRTS 413
V + + DV D P+F Y F +E Q+ +G V A+D D + YS
Sbjct: 1084 VNVTVILEDVNDNRPLFNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEMVQ 1143
Query: 414 DKGQFFRVTKKGDIYNEKELDREVY------PWYNLTVEAKELDSTGTPTGKESIVQVHI 467
+ ++ G+I N + DRE ++ TV A + G P + VH+
Sbjct: 1144 PDFELHAIS--GEITNTHQFDRESLMRRRGTAVFSFTVIATD---QGIPQPLKDQATVHV 1198
Query: 468 EVLDENDNAPEFAKP-YQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFIL--NTENNF 524
+ D NDNAP+F K YQ + E+A + VL++SA D D + I+ N E F
Sbjct: 1199 YMKDINDNAPKFLKDFYQATISESAANLTQVLRVSASDVDEGNNGLIHYSIIKGNEERQF 1258
Query: 525 TLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 580
+ D+T+ G+ D E T + L + D+G T TL + + N+
Sbjct: 1259 AI----DSTSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDILDEND 1310
Score = 155 bits (391), Expect = 2e-37
Identities = 157/540 (29%), Positives = 240/540 (44%), Gaps = 57/540 (10%)
Query: 66 HHVGKIKSSVSRKNA--------KYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYH 117
H +G I +VS ++ KY + +F +++ TG + + LD E ++
Sbjct: 3102 HSIGSIVRTVSARDRDAAMNGLIKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHE 3161
Query: 118 LTAVIVDKD----TGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISV 173
+T +D TG S T+ V DVNDN PVF + +V E++ GT+VI +
Sbjct: 3162 MTISAIDGGWVARTGY-----CSVTVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHL 3216
Query: 174 TAVDADDPTVGDHASVMYQILKG-KEYFAIDNSGRIITITKSLDREKQARYEIVVEARDA 232
A DAD G +A + Y + + F ID + +IT LD E + Y + V+A +
Sbjct: 3217 NATDADS---GTNAVIAYTVQSSDSDLFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNV 3273
Query: 233 QGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRM 292
S ATV + L+ N+ P F Y F + E GT VG +F D D +
Sbjct: 3274 PDEERCS-FATVNIQLKGTNEYVPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGE 3332
Query: 293 TKYSILRGDYQDAFTI--ETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMS 350
Y I + F I +T + GI LD E ++ S V A + + S
Sbjct: 3333 VHYLIFGNSRKKGFQINKKTGQIYVSGI------LDREKEERVSLKVLAKN------FGS 3380
Query: 351 PPAGNRAQVIINIT--DVDEPPIFQQPFYHFQLKENQKKPLIGT----VLAMDPDA--AR 402
+ +V +N+T D ++PPIF Y Q+ E IGT V A D D+ +
Sbjct: 3381 IRGADIDEVTVNVTVLDANDPPIFTLNIYSVQISEGVP---IGTHVTFVSAFDSDSIPSW 3437
Query: 403 HSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTP--TGKE 460
Y I ++ G F + G I ELDRE P YNL+V A + +GTP TG
Sbjct: 3438 SRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLSVLAVD---SGTPSATGSA 3494
Query: 461 SIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNT 520
S++ + + D NDN P + +V EN G LV+ + + D D+ P F + L +
Sbjct: 3495 SLL---VTLEDINDNGPMLTVS-EGEVMENKRPGTLVMTLQSTDPDLPPNQGPFTYYLLS 3550
Query: 521 ENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 580
T + +TA + + DRE +L VV D+G+P + T T+ + V N+
Sbjct: 3551 TGPATSYFSL-STAGVLSTTREIDREQIADFYLSVVTKDSGVPQMSSTGTVHITVIDQND 3609
Score = 154 bits (390), Expect = 2e-37
Identities = 152/483 (31%), Positives = 224/483 (46%), Gaps = 41/483 (8%)
Query: 108 LDRENISEYHLTAVIVDKDTGENLETP-SSFTIKVHDVNDNWPVFTH-RLFNASVPESSA 165
LDRE S+ L I +D G + + + + + DVND PVF+ ++ SV E++
Sbjct: 540 LDRELASQIVLN--ISARDQGVHPKVSYAQLVVTLLDVNDEKPVFSQPEGYDVSVVENAP 597
Query: 166 VGTSVISVTAVDADDPTVGDHASVMYQILKG---KEYFAIDN-SGRIITITKSLDREKQA 221
GT ++ + A D D +GD+ +V + + + + F +D SGR+ TI+ SLDRE+QA
Sbjct: 598 TGTELLMLRATDGD---LGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTIS-SLDREEQA 653
Query: 222 RYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLF 281
Y ++V A D G S A + V+L DINDN P F +Y + E+ G+ + ++
Sbjct: 654 FYSLLVLATDL-GSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVS 712
Query: 282 VEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATD 341
DPD N KYSI GD + F + G+I LD E Y + ATD
Sbjct: 713 ATDPDLGTNGTVKYSISAGD-RSRFQVNA----QSGVISTRMALDREEKTAYQLQIVATD 767
Query: 342 PTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQLKENQKKPL-IGTVLAMDPD 399
SP N+A V I + D D PP+F Q Y F + EN +G+V A D
Sbjct: 768 GG---NLQSP---NQAIVTITVLDTQDNPPVFSQVAYSFVVFENVALGYHVGSVSASTMD 821
Query: 400 AARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGK 459
+I Y I KG F G + +DRE +Y L V A S GT TG
Sbjct: 822 -LNSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA----SGGTVTGD 876
Query: 460 ESIVQVHIEVLDENDNAPEFAKPYQP-KVCENAVHGQLVLQISAIDKDITPRN-VKFKFI 517
V+I V D NDN+P F + + V EN G + Q A+D D V +
Sbjct: 877 ---TMVNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNGMVLYSLK 933
Query: 518 LNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCK 577
N +N F + + + + + G D H + + ++ SD G+P + + LTV V
Sbjct: 934 QNPKNLFAINEKNGTISLL----GPLD-VHAGSYQIEILASDMGVPQLSSSVILTVYVHD 988
Query: 578 CNE 580
N+
Sbjct: 989 VND 991
Score = 152 bits (385), Expect = 9e-37
Identities = 138/496 (27%), Positives = 231/496 (46%), Gaps = 44/496 (8%)
Query: 93 FRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFT 152
F ++ TG + LDRE Y L V D + E L + +S + V DVNDN P F
Sbjct: 2408 FTINPSTGQIITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQ 2467
Query: 153 HRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQIL-KGKEYFAIDNSGRIITI 211
H + +P + G+ V +VT DAD +G ++ + Y + + E F ID I
Sbjct: 2468 HHPYVTHIPSPTLPGSFVFAVTVTDAD---IGPNSELHYSLSGRNSEKFHIDPLRGAIMA 2524
Query: 212 TKSLDREKQARYEIVVEARDAQGLRGDSG----TATVLVTLQDIND-NFPFFTQTKYTFV 266
L+ + + + V+ D G T + VT++ +N +FP + TF+
Sbjct: 2525 AGPLNGASEVTFSVHVK---------DGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFM 2575
Query: 267 VPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLD 326
PE+ V + V ++ + Y I G+ + F I+ G + +PLD
Sbjct: 2576 FPENQPVSSLVTTI---TGSSLRGEPMSYYIASGNLGNTFQID----QLTGQVSISQPLD 2628
Query: 327 YEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQLKENQ 385
+E IQ+Y +EA D PP + ++ I + DV D PIF++ + ++ EN
Sbjct: 2629 FEKIQKYVVWIEARDGGF------PPFSSYEKLDITVLDVNDNAPIFKEDPFISEILENL 2682
Query: 386 KKPLIGTVLAMDPDAARH-SIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLT 444
I TV AMD D+ + + Y I + + F G+I + + LDRE Y LT
Sbjct: 2683 SPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSINHATGEIRSVRPLDREKVSHYVLT 2742
Query: 445 VEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAID 504
+++ + G+P+ S V+V I +LDENDNAP F++ + V EN+ G V +++ D
Sbjct: 2743 IKSSD---KGSPSQSTS-VKVMINILDENDNAPRFSQIFSAHVPENSPLGYTVTRVTTSD 2798
Query: 505 KDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPS 564
+DI + I++ FT+ + +T +I + +RE T + + V D+G
Sbjct: 2799 EDIGINAISRYSIMDASLPFTI---NPSTGDIVIS-RPLNREDTDRYRIRVSAHDSGW-- 2852
Query: 565 RTGTSTLTVAVCKCNE 580
T ++ +T+ V N+
Sbjct: 2853 -TVSTDVTIFVTDIND 2867
Score = 152 bits (384), Expect = 1e-36
Identities = 154/531 (29%), Positives = 243/531 (45%), Gaps = 41/531 (7%)
Query: 61 NTSLPHHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTA 120
+T L +V ++ + + G+ +G+ F VD + G + ++ LDRE+ S Y+L
Sbjct: 1961 STVLVFNVTDADDGINSQLTYSIASGDSLGQ-FTVD-KNGVLKVLKALDRESQSFYNLVV 2018
Query: 121 VIVD--KDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDA 178
+ D + + + +I + DVNDN P F +PE++ + T V A D
Sbjct: 2019 QVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTY-IPENTPIDTVVFKAQATDP 2077
Query: 179 DDPTVGDHASVMYQILKGK-EYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRG 237
D G ++ + Y +L F+I + +T LDRE+ + Y + V A D +G
Sbjct: 2078 DS---GPNSYIEYTLLNPLGNKFSIGTIDGEVRLTGELDREEVSNYTLTVVATD-KGQPS 2133
Query: 238 DSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSI 297
S + V+V + DINDN P F Q Y + E+T GT + +F D DE N +Y I
Sbjct: 2134 LSSSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGI 2193
Query: 298 LRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRA 357
+ G+ F I++ G I KPLD E Y V+ATD S P + +
Sbjct: 2194 VNGNTNQEFRIDS----VTGAITVAKPLDREKTPTYHLTVQATDRG------STPRTDTS 2243
Query: 358 QVIINITDV-DEPPIFQQPFYHFQLKEN--QKKPLIGTVLAMDPDAARHSIGYSIRRTSD 414
V I + D+ D P+F+ Y + EN I V+A D D +S + +
Sbjct: 2244 TVSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGN 2303
Query: 415 KGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDS---TGTPTGKESIVQVHIEVLD 471
+ F ++ G++ + LDRE + L + A + S TGT T +++ V D
Sbjct: 2304 EDNAFTLSASGELGVTQSLDRETKERFVLMITATDSGSPALTGTGT-------INVIVDD 2356
Query: 472 ENDNAPEFA-KPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFILNTENNFTLTDNH 530
NDN P FA K Y + E+A G VL ++A D D + +N + I+ + FT+ +
Sbjct: 2357 VNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADAS-KNAVIR-IIGGNSQFTI---N 2411
Query: 531 DNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTST-LTVAVCKCNE 580
+T I + DRE + L VV SD G P +ST + V V N+
Sbjct: 2412 PSTGQI-ITSALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVND 2461
Score = 135 bits (341), Expect = 1e-31
Identities = 145/511 (28%), Positives = 229/511 (44%), Gaps = 39/511 (7%)
Query: 76 SRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPS 135
S Y+L G F + A +G++ + LDRE + L D + L
Sbjct: 2291 SNSKLSYVLFGGNEDNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGSPA-LTGTG 2348
Query: 136 SFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILK 195
+ + V DVNDN P F + + ++PE + GT V+ V A DAD + + +I+
Sbjct: 2349 TINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASK-----NAVIRIIG 2403
Query: 196 GKEYFAIDNS-GRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDN 254
G F I+ S G+IIT + LDRE + Y +VV DA S + +VLVT+ D+NDN
Sbjct: 2404 GNSQFTINPSTGQIIT-SALLDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTVTDVNDN 2462
Query: 255 FPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAH 314
P F Y +P T G+ V ++ V D D N YS L G + F I+
Sbjct: 2463 PPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYS-LSGRNSEKFHIDP---- 2517
Query: 315 NEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDVDEPPIFQQ 374
G I PL+ + +F V D S P + V + + + P +
Sbjct: 2518 LRGAIMAAGPLN--GASEVTFSVHVKDGG------SFPKTDSTTVTVRFVNKADFPKVRA 2569
Query: 375 PFYHFQLKENQKKPLIGTVLAMDPDAAR-HSIGYSIRRTSDKGQFFRVTK-KGDIYNEKE 432
F ENQ P+ V + + R + Y I + + G F++ + G + +
Sbjct: 2570 KEQTFMFPENQ--PVSSLVTTITGSSLRGEPMSYYI-ASGNLGNTFQIDQLTGQVSISQP 2626
Query: 433 LDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAK-PYQPKVCENA 491
LD E Y + +EA++ G S ++ I VLD NDNAP F + P+ ++ EN
Sbjct: 2627 LDFEKIQKYVVWIEARD----GGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISEILEN- 2681
Query: 492 VHGQLVLQISAIDKDITPRNVKFKFIL--NTENNFTLTDNHDNTANITVKYGQFDREHTK 549
+ + +L +SA+DKD P I+ N EN+F++ NH +V+ DRE
Sbjct: 2682 LSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENSFSI--NHATGEIRSVR--PLDREKVS 2737
Query: 550 VHFLPVVISDNGMPSRTGTSTLTVAVCKCNE 580
+ L + SD G PS++ + + + + N+
Sbjct: 2738 HYVLTIKSSDKGSPSQSTSVKVMINILDEND 2768
Score = 124 bits (311), Expect = 3e-28
Identities = 135/508 (26%), Positives = 214/508 (42%), Gaps = 44/508 (8%)
Query: 83 LLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVH 142
L + E + FR+D +G + I LDRE + Y L + D + + + + +
Sbjct: 622 LQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATDLGSPPQ-SSMARINVSLL 680
Query: 143 DVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKG-KEYFA 201
D+NDN PVF + A + E+ G+ +T V A DP +G + +V Y I G + F
Sbjct: 681 DINDNSPVFYPVQYFAHIKENEPGGS---YITTVSATDPDLGTNGTVKYSISAGDRSRFQ 737
Query: 202 IDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQT 261
++ +I+ +LDRE++ Y++ + A D L+ + A V +T+ D DN P F+Q
Sbjct: 738 VNAQSGVISTRMALDREEKTAYQLQIVATDGGNLQSPN-QAIVTITVLDTQDNPPVFSQV 796
Query: 262 KYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKP 321
Y+FVV E+ +G VGS+ D N Y I GD + F I G +
Sbjct: 797 AYSFVVFENVALGYHVGSVSASTMD--LNSNISYLITTGDQKGMFAIN----QVTGQLTT 850
Query: 322 MKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQ 380
+D E Y V A+ T+ V I + D+ D P F Q
Sbjct: 851 ANVIDREEQSFYQLKVVASGGTVT---------GDTMVNITVKDLNDNSPHFLQAIESVN 901
Query: 381 LKEN-QKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYP 439
+ EN Q I A+DPD + + + + K F K G I LD
Sbjct: 902 VVENWQAGHSIFQAKAVDPDEGVNGMVLYSLKQNPKNLFAINEKNGTISLLGPLDVHAGS 961
Query: 440 WYNLTVEAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAK-PYQPKVCENAVHGQLVL 498
Y + + A ++ G P S++ + + V D NDN+P F + Y+ + E+
Sbjct: 962 -YQIEILASDM---GVPQLSSSVI-LTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFF 1016
Query: 499 QISAIDKDITPRNVKFKFILNTENNFTLTDNHDNTANITVKYGQ------FDREHTKVHF 552
++ A DKD N E +T+ + + A GQ DRE +
Sbjct: 1017 KVQASDKDSG---------ANGEIAYTIAEGNTGDAFGIFPDGQLYIKSELDRELQDRYV 1067
Query: 553 LPVVISDNGMPSRTGTSTLTVAVCKCNE 580
L VV SD + + T +TV + N+
Sbjct: 1068 LMVVASDRAVEPLSATVNVTVILEDVND 1095
Score = 122 bits (307), Expect = 1e-27
Identities = 151/532 (28%), Positives = 228/532 (42%), Gaps = 54/532 (10%)
Query: 68 VGKIKSSVSRKNAK--------YLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLT 119
+G++ SSV+ ++ Y + G F + TG +F ++LD E S Y L
Sbjct: 1330 IGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLN 1389
Query: 120 AVIVDKDTGENLETPS-SFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDA 178
I KD G + + S I V D NDN P F S+ E+ +GTSVISVTA D
Sbjct: 1390 --ITAKDQGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDP 1447
Query: 179 DDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARD----AQG 234
D G + + Q + +F ID I +DRE +E+ V+A D +
Sbjct: 1448 DADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREFANLFELTVKANDQAVPIET 1507
Query: 235 LRGDSGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTK 294
R T+LVT D+NDN P F P +G+ + ++ DPDE N +
Sbjct: 1508 RRYALKNVTILVT--DLNDNVPMFISQNALAADPSAV-IGSVLTTIMAADPDEGANGEIE 1564
Query: 295 YSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAG 354
Y I+ GD D F ++ G ++ L + Y+ IV ATD + P
Sbjct: 1565 YEIINGD-TDTFIVD----RYSGDLRVASALVPSQL-IYNLIVSATD-------LGPERR 1611
Query: 355 NRAQVIINITDVDEPPIFQQPFYHFQLKENQKKPLIGT----VLAMDPDAARHSIGYSI- 409
+ I + P+F QP Y LKE + IGT + A P + + Y I
Sbjct: 1612 KSTTELTIILQGLDGPVFTQPKYITILKEGEP---IGTNVISIEAASPRGSEAPVEYYIV 1668
Query: 410 -RRTSDK--GQFFRVTK-KGDIYNEKELDREVYP-WYNLTVEAKELDSTGTPTGKESIVQ 464
R +K G+ F + + G I LDRE Y + V A E ST P + + +
Sbjct: 1669 SVRCEEKTVGRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIE-KSTAFPRTQRA--E 1725
Query: 465 VHIEVLDENDNAPEF-AKPYQPKVCENAVHGQLVLQISAIDKDITPRN-VKFKFILNTEN 522
V I + D NDN P F V EN G ++Q++A+D D V + I ++
Sbjct: 1726 VEITLQDINDNPPVFPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALVTYTIISGADD 1785
Query: 523 NFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVA 574
+F + D + + + DRE + L +V +D+G+ S +TV+
Sbjct: 1786 SFRI----DPESGDLIATRRLDRERRSKYSL-LVRADDGLQSSDMRINITVS 1832
Score = 109 bits (272), Expect = 1e-23
Identities = 115/397 (28%), Positives = 176/397 (44%), Gaps = 39/397 (9%)
Query: 92 VFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVF 151
+F +D TG + LD E YHLT + E ++ I++ N+ P F
Sbjct: 3240 LFVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSF-ATVNIQLKGTNEYVPRF 3298
Query: 152 THRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKG--KEYFAIDNSGRII 209
+L+ + E++ GT V V A D D +G V Y I K+ F I+ I
Sbjct: 3299 VSKLYYFEISEAAPKGTIVGEVFASDRD---LGTDGEVHYLIFGNSRKKGFQINKKTGQI 3355
Query: 210 TITKSLDREKQARYEIVVEARDAQGLRG-DSGTATVLVTLQDINDNFPFFTQTKYTFVVP 268
++ LDREK+ R + V A++ +RG D TV VT+ D ND P FT Y+ +
Sbjct: 3356 YVSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDP-PIFTLNIYSVQIS 3414
Query: 269 EDTRVGTSVGSLFVEDPDE-PQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDY 327
E +GT V + D D P Y I G+ AF+I NP G I LD
Sbjct: 3415 EGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSI--NP--QTGQITVTAELDR 3470
Query: 328 EYIQQYSFIVEATDPTIDLRYMSPPAGNRAQVIINITDV-DEPPIFQQPFYHFQLKENQK 386
E + Y+ V A D +P A A +++ + D+ D P+ ++ EN++
Sbjct: 3471 ETLPIYNLSVLAVDSG------TPSATGSASLLVTLEDINDNGPMLTVS--EGEVMENKR 3522
Query: 387 K-PLIGTVLAMDPDAARHS--IGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNL 443
L+ T+ + DPD + Y + T +F ++ G + +E+DRE + L
Sbjct: 3523 PGTLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSLSTAGVLSTTREIDREQIADFYL 3582
Query: 444 TVEAKE-----LDSTGTPTGKESIVQVHIEVLDENDN 475
+V K+ + STGT VHI V+D+NDN
Sbjct: 3583 SVVTKDSGVPQMSSTGT---------VHITVIDQNDN 3610
Score = 85.1 bits (209), Expect = 2e-16
Identities = 109/430 (25%), Positives = 176/430 (40%), Gaps = 53/430 (12%)
Query: 182 TVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGT 241
T+ Y++ + FAI++S + T ++DRE I + + +
Sbjct: 63 TIQTRPGFTYRLSESHALFAINSSTGALYTTSTIDRESLPSDVINLVVLSS----APTYP 118
Query: 242 ATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRM--TKYSILR 299
V V ++D+NDN P F ED+ G V D D N + Y I+R
Sbjct: 119 TEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILDTATDSDIGSNGVDHRSYRIIR 178
Query: 300 GDYQDAFTIE--TNPAHNEGIIKPMKP--LDYEYIQQYSFIVEATDPTIDLRYMSPPAGN 355
G+ F ++ NP+ + + LD E QY +VE D P
Sbjct: 179 GNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQYQLLVEVEDKG------EPKRRG 232
Query: 356 RAQVIINITDV-DEPPIFQQPFYHFQLKENQKKPLIGT----VLAMDPDAARHS-IGYSI 409
QV + + D+ D PP+F Y + E+ ++G+ V A D D ++ I Y
Sbjct: 233 YLQVNVTVQDINDNPPVFGSSHYQAGVPED---AVVGSSVLQVAAADADEGTNADIRY-- 287
Query: 410 RRTSDKGQFFRVTKKGDIYNEKE-LDREVYPWYNLTVEAKELDSTGTP--TGKESIVQVH 466
R D+G F++ + + +E LD E Y+LTV+A + G P TG+ +
Sbjct: 288 -RLQDEGTPFQMDPETGLITVREPLDFEARRQYSLTVQAMD---RGVPSLTGR---AEAL 340
Query: 467 IEVLDENDNAPEFAKPYQP------KVCENAVHGQLVLQISAIDKDITPRNVKFKFIL-- 518
I++LD NDN P Y P V ENA G +V ++ D D N +
Sbjct: 341 IQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVTDADSPAANGNISVQILG 400
Query: 519 -NTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDN-GMP------SRTGTST 570
N + +F + + ++ DRE + L V +SDN G P +R+ ++
Sbjct: 401 GNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDNYGAPPGAAVQARSSVAS 460
Query: 571 LTVAVCKCNE 580
L + V N+
Sbjct: 461 LVIFVNDIND 470
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.391
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,572,977
Number of Sequences: 37866
Number of extensions: 1460848
Number of successful extensions: 9554
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 192
Number of HSP's successfully gapped in prelim test: 31
Number of HSP's that attempted gapping in prelim test: 4124
Number of HSP's gapped (non-prelim): 910
length of query: 784
length of database: 18,247,518
effective HSP length: 110
effective length of query: 674
effective length of database: 14,082,258
effective search space: 9491441892
effective search space used: 9491441892
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.