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Search of human proteins with 166197671
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|166197671 adaptor-related protein complex 4, beta 1 subunit
[Homo sapiens]
(739 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|166197671 adaptor-related protein complex 4, beta 1 subunit [... 1482 0.0
gi|71773106 adaptor-related protein complex 2, beta 1 subunit is... 301 1e-81
gi|4557469 adaptor-related protein complex 2, beta 1 subunit iso... 301 1e-81
gi|22027651 adaptor-related protein complex 1 beta 1 subunit iso... 296 5e-80
gi|22027653 adaptor-related protein complex 1 beta 1 subunit iso... 296 5e-80
gi|34482047 adaptor-related protein complex 3, beta 2 subunit [H... 179 6e-45
gi|32484979 adaptor-related protein complex 3, beta 1 subunit [H... 165 1e-40
gi|109134349 coatomer protein complex, subunit gamma 2 [Homo sap... 68 3e-11
gi|11559929 coatomer protein complex, subunit gamma 1 [Homo sapi... 57 8e-08
gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [H... 51 3e-06
gi|117553580 adaptor-related protein complex 3, delta 1 subunit ... 49 2e-05
gi|221316632 coatomer protein complex, subunit beta 1 [Homo sapi... 44 5e-04
gi|221316630 coatomer protein complex, subunit beta 1 [Homo sapi... 44 5e-04
gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens] 44 5e-04
gi|71773010 adaptor-related protein complex 1, gamma 1 subunit i... 42 0.003
gi|71772942 adaptor-related protein complex 1, gamma 1 subunit i... 41 0.004
gi|27477041 adaptor-related protein complex 2, alpha 2 subunit [... 41 0.005
gi|117553584 adaptor-related protein complex 3, delta 1 subunit ... 35 0.33
gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypept... 32 1.6
gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens] 32 1.6
gi|214010165 rab11-family interacting protein 3 isoform 2 [Homo ... 31 3.6
gi|7662234 rab11-family interacting protein 3 isoform 1 [Homo sa... 31 3.6
gi|45331213 RAN binding protein 6 [Homo sapiens] 31 3.6
gi|19913414 adaptor-related protein complex 2, alpha 1 subunit i... 31 3.6
gi|19913416 adaptor-related protein complex 2, alpha 1 subunit i... 31 3.6
gi|109715835 HEAT repeat containing 6 [Homo sapiens] 31 3.6
gi|153266841 apolipoprotein H precursor [Homo sapiens] 31 4.7
gi|55742730 storkhead box 2 [Homo sapiens] 31 4.7
gi|4504811 junction plakoglobin [Homo sapiens] 30 6.2
gi|12056468 junction plakoglobin [Homo sapiens] 30 6.2
>gi|166197671 adaptor-related protein complex 4, beta 1 subunit
[Homo sapiens]
Length = 739
Score = 1482 bits (3836), Expect = 0.0
Identities = 739/739 (100%), Positives = 739/739 (100%)
Query: 1 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV 60
MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV
Sbjct: 1 MPYLGSEDVVKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV 60
Query: 61 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY 120
DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY
Sbjct: 61 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY 120
Query: 121 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL 180
IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL
Sbjct: 121 IQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCL 180
Query: 181 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL 240
RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL
Sbjct: 181 RSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLL 240
Query: 241 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV 300
DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV
Sbjct: 241 DSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHV 300
Query: 301 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS 360
RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS
Sbjct: 301 RQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVS 360
Query: 361 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC 420
ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC
Sbjct: 361 ADFAQAAIFAIGGIARTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVC 420
Query: 421 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAL 480
QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAL
Sbjct: 421 QALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTAL 480
Query: 481 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP 540
LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP
Sbjct: 481 LRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDP 540
Query: 541 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL 600
TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL
Sbjct: 541 TLGLLEDPAERPVNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL 600
Query: 601 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA 660
IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA
Sbjct: 601 IPEENKERVQELPDSGALMLVPNRQLTADYFEKTWLSLKVAHQQVLPWRGEFHPDTLQMA 660
Query: 661 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL 720
LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL
Sbjct: 661 LQVVNIQTIAMSRAGSRPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVKQNEARTETL 720
Query: 721 NSFISVLETVIGTIEEIKS 739
NSFISVLETVIGTIEEIKS
Sbjct: 721 NSFISVLETVIGTIEEIKS 739
>gi|71773106 adaptor-related protein complex 2, beta 1 subunit
isoform a [Homo sapiens]
Length = 951
Score = 301 bits (772), Expect = 1e-81
Identities = 184/619 (29%), Positives = 325/619 (52%), Gaps = 18/619 (2%)
Query: 12 ELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLY 71
ELK L N + + + +++VI MT G D+S +F ++V T ++ KKLVYLY
Sbjct: 17 ELKAELNNEKKE----KRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLY 72
Query: 72 MCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRD 131
+ YA +PD+A++A+N+ KDC DPNP++R LA+R+M +R+ + EY+ +P+ L+D
Sbjct: 73 LMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKD 132
Query: 132 KASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEG 191
+ YVR+ A + AK+H+++ D ++ L L+ D +P+VV N + +L EI +
Sbjct: 133 EDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHP 192
Query: 192 G---VVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSS 248
+ +N + LL +++ +WGQ +L+ L Y P+ + E I + L ++
Sbjct: 193 NSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHAN 252
Query: 249 PGVVMGATKLFLILAKMFPHVQT--DVLVRVKGPLLAACSSESRELCFVALCHVRQILHS 306
VV+ A K+ + ++ P ++L++ P L S E+ +VAL ++ I+
Sbjct: 253 SAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQK 312
Query: 307 LPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQA 366
P K FF Y++P Y+KL+K++++ L + N+ QVL EL+ Y T+V DF +
Sbjct: 313 RPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRK 372
Query: 367 AIFAIGGIA---RTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQAL 423
A+ AIG A ++CV L +L+ + ++ + RD+ P E++ L
Sbjct: 373 AVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATL 432
Query: 424 PGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRL 483
+++ + + + A+IW++G + ERI NA +LE F+E E+ V++ LLTA+++L
Sbjct: 433 CENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDES-TQVQLTLLTAIVKL 491
Query: 484 FLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTLG 543
FL +P+E Q+++ ++L ++ + +RDRG Y+RLL K ++ S K P +
Sbjct: 492 FLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEK--PLIS 549
Query: 544 LLEDPAERP-VNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL-- 600
D E ++ +L VY K A + G R + S+ A P+
Sbjct: 550 EETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGT 609
Query: 601 IPEENKERVQELPDSGALM 619
N E+ Q +P G L+
Sbjct: 610 TTATNLEQPQVIPSQGDLL 628
Score = 30.8 bits (68), Expect = 4.7
Identities = 24/95 (25%), Positives = 41/95 (43%), Gaps = 2/95 (2%)
Query: 618 LMLVPNRQLTADYFEKTWLSLKVAHQ-QVLPWRGEFHPDTLQMALQVVNIQTIAMSRAGS 676
++ V + ++ F TW + ++ Q + DT+ LQ N+ TIA
Sbjct: 838 VLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEG 897
Query: 677 RPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVK 711
+ Y S + G L EL ++PGN +S+K
Sbjct: 898 QDM-LYQSLKLTNGIWILAELRIQPGNPNYTLSLK 931
>gi|4557469 adaptor-related protein complex 2, beta 1 subunit
isoform b [Homo sapiens]
Length = 937
Score = 301 bits (772), Expect = 1e-81
Identities = 184/619 (29%), Positives = 325/619 (52%), Gaps = 18/619 (2%)
Query: 12 ELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLY 71
ELK L N + + + +++VI MT G D+S +F ++V T ++ KKLVYLY
Sbjct: 17 ELKAELNNEKKE----KRKEAVKKVIAAMTVGKDVSSLFPDVVNCMQTDNLELKKLVYLY 72
Query: 72 MCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRD 131
+ YA +PD+A++A+N+ KDC DPNP++R LA+R+M +R+ + EY+ +P+ L+D
Sbjct: 73 LMNYAKSQPDMAIMAVNSFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKD 132
Query: 132 KASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEG 191
+ YVR+ A + AK+H+++ D ++ L L+ D +P+VV N + +L EI +
Sbjct: 133 EDPYVRKTAAVCVAKLHDINAQMVEDQGFLDSLRDLIADSNPMVVANAVAALSEISESHP 192
Query: 192 G---VVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSS 248
+ +N + LL +++ +WGQ +L+ L Y P+ + E I + L ++
Sbjct: 193 NSNLLDLNPQNINKLLTALNECTEWGQIFILDCLSNYNPKDDREAQSICERVTPRLSHAN 252
Query: 249 PGVVMGATKLFLILAKMFPHVQT--DVLVRVKGPLLAACSSESRELCFVALCHVRQILHS 306
VV+ A K+ + ++ P ++L++ P L S E+ +VAL ++ I+
Sbjct: 253 SAVVLSAVKVLMKFLELLPKDSDYYNMLLKKLAPPLVTLLSGEPEVQYVALRNINLIVQK 312
Query: 307 LPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQA 366
P K FF Y++P Y+KL+K++++ L + N+ QVL EL+ Y T+V DF +
Sbjct: 313 RPEILKQEIKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRK 372
Query: 367 AIFAIGGIA---RTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQAL 423
A+ AIG A ++CV L +L+ + ++ + RD+ P E++ L
Sbjct: 373 AVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIRDIFRKYPNKYESIIATL 432
Query: 424 PGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRL 483
+++ + + + A+IW++G + ERI NA +LE F+E E+ V++ LLTA+++L
Sbjct: 433 CENLDSLDEPDARAAMIWIVGEYAERIDNADELLESFLEGFHDES-TQVQLTLLTAIVKL 491
Query: 484 FLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPKSDPTLG 543
FL +P+E Q+++ ++L ++ + +RDRG Y+RLL K ++ S K P +
Sbjct: 492 FLKKPSETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVTAKEVVLSEK--PLIS 549
Query: 544 LLEDPAERP-VNSWASDFNTLVPVYGKAHWATISKCQGAERCDPELPKTSSFAASGPL-- 600
D E ++ +L VY K A + G R + S+ A P+
Sbjct: 550 EETDLIEPTLLDELICHIGSLASVYHKPPNAFVEGSHGIHRKHLPIHHGSTDAGDSPVGT 609
Query: 601 IPEENKERVQELPDSGALM 619
N E+ Q +P G L+
Sbjct: 610 TTATNLEQPQVIPSQGDLL 628
Score = 30.8 bits (68), Expect = 4.7
Identities = 24/95 (25%), Positives = 41/95 (43%), Gaps = 2/95 (2%)
Query: 618 LMLVPNRQLTADYFEKTWLSLKVAHQ-QVLPWRGEFHPDTLQMALQVVNIQTIAMSRAGS 676
++ V + ++ F TW + ++ Q + DT+ LQ N+ TIA
Sbjct: 824 VLFVEDGKMERQVFLATWKDIPNENELQFQIKECHLNADTVSSKLQNNNVYTIAKRNVEG 883
Query: 677 RPWKAYLSAQDDTGCLFLTELLLEPGNSEMQISVK 711
+ Y S + G L EL ++PGN +S+K
Sbjct: 884 QDM-LYQSLKLTNGIWILAELRIQPGNPNYTLSLK 917
>gi|22027651 adaptor-related protein complex 1 beta 1 subunit
isoform a [Homo sapiens]
Length = 949
Score = 296 bits (758), Expect = 5e-80
Identities = 165/518 (31%), Positives = 293/518 (56%), Gaps = 13/518 (2%)
Query: 30 RNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINT 89
+ +++VI MT G D+S +F ++V T ++ KKLVYLY+ YA +PD+A++A+NT
Sbjct: 31 KEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNT 90
Query: 90 LCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHN 149
KDC DPNP++R LA+R+M +R+ + EY+ +P+ L+D+ YVR+ A + AK+H+
Sbjct: 91 FVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHD 150
Query: 150 LHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGG---VVINKPIAHHLLNR 206
++ D ++ L L+ D +P+VV N + +L EI + + +N + LL
Sbjct: 151 INAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTA 210
Query: 207 MSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSSPGVVMGATKLFL----IL 262
+++ +WGQ +L+ L Y P+ + E I + L ++ VV+ A K+ + +L
Sbjct: 211 LNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML 270
Query: 263 AKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHYKKFFCSY 322
+K + T +L ++ PL+ S+E EL +VAL ++ I+ P K FF Y
Sbjct: 271 SKDLDYYGT-LLKKLAPPLVTLLSAEP-ELQYVALRNINLIVQKRPEILKHEMKVFFVKY 328
Query: 323 SEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIFAIGGIA---RTYT 379
++P Y+KL+K++++ L + N+ QVL EL+ Y T+V DF + A+ AIG A
Sbjct: 329 NDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSA 388
Query: 380 DQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEENIQDSEGKQAL 439
++CV L +L+ + ++ + +D+ P E+V L +++ + E + A+
Sbjct: 389 ERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAM 448
Query: 440 IWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRLFLSRPAECQDMLGRLL 499
IW++G + ERI NA +LE F+E E+ V+++LLTA+++LFL +P E Q+++ ++L
Sbjct: 449 IWIVGEYAERIDNADELLESFLEGFHDES-TQVQLQLLTAIVKLFLKKPTETQELVQQVL 507
Query: 500 YYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPK 537
++ + +RDRG Y+RLL K ++ + K
Sbjct: 508 SLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEK 545
>gi|22027653 adaptor-related protein complex 1 beta 1 subunit
isoform b [Homo sapiens]
Length = 942
Score = 296 bits (758), Expect = 5e-80
Identities = 165/518 (31%), Positives = 293/518 (56%), Gaps = 13/518 (2%)
Query: 30 RNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINT 89
+ +++VI MT G D+S +F ++V T ++ KKLVYLY+ YA +PD+A++A+NT
Sbjct: 31 KEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNT 90
Query: 90 LCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHN 149
KDC DPNP++R LA+R+M +R+ + EY+ +P+ L+D+ YVR+ A + AK+H+
Sbjct: 91 FVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHD 150
Query: 150 LHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGG---VVINKPIAHHLLNR 206
++ D ++ L L+ D +P+VV N + +L EI + + +N + LL
Sbjct: 151 INAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTA 210
Query: 207 MSKLDQWGQAEVLNFLLRYQPRSEEELFDILNLLDSFLKSSSPGVVMGATKLFL----IL 262
+++ +WGQ +L+ L Y P+ + E I + L ++ VV+ A K+ + +L
Sbjct: 211 LNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEML 270
Query: 263 AKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHYKKFFCSY 322
+K + T +L ++ PL+ S+E EL +VAL ++ I+ P K FF Y
Sbjct: 271 SKDLDYYGT-LLKKLAPPLVTLLSAEP-ELQYVALRNINLIVQKRPEILKHEMKVFFVKY 328
Query: 323 SEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIFAIGGIA---RTYT 379
++P Y+KL+K++++ L + N+ QVL EL+ Y T+V DF + A+ AIG A
Sbjct: 329 NDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSA 388
Query: 380 DQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEAVCQALPGCEENIQDSEGKQAL 439
++CV L +L+ + ++ + +D+ P E+V L +++ + E + A+
Sbjct: 389 ERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAM 448
Query: 440 IWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRLFLSRPAECQDMLGRLL 499
IW++G + ERI NA +LE F+E E+ V+++LLTA+++LFL +P E Q+++ ++L
Sbjct: 449 IWIVGEYAERIDNADELLESFLEGFHDES-TQVQLQLLTAIVKLFLKKPTETQELVQQVL 507
Query: 500 YYCIEEEKDMAVRDRGLFYYRLLLVGIDEVKRILCSPK 537
++ + +RDRG Y+RLL K ++ + K
Sbjct: 508 SLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEK 545
>gi|34482047 adaptor-related protein complex 3, beta 2 subunit [Homo
sapiens]
Length = 1082
Score = 179 bits (455), Expect = 6e-45
Identities = 145/568 (25%), Positives = 257/568 (45%), Gaps = 71/568 (12%)
Query: 33 IQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINTLCK 92
++R++ + +G + S +F +VK A +I KKLVY+Y+ YA + DLALL+I+T +
Sbjct: 58 MKRIVAMIARGKNASDLFPAVVKNVACKNIEVKKLVYVYLVRYAEEQQDLALLSISTFQR 117
Query: 93 DCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHG 152
DPN ++R ALR + S+R+P + + I D + YVR+ A K+++L
Sbjct: 118 GLKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEAASDMSPYVRKTAAHAIPKLYSL-- 175
Query: 153 DSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQ 212
DS+ L+ + LL D+ +V + + + EE+ + ++ L N + +++
Sbjct: 176 DSDQKDQLIEVIEKLLADKTTLVAGSVVMAFEEVCPERIDLIHKN--YRKLCNLLIDVEE 233
Query: 213 WGQAEVLNFLLRY------QPRSEEELFD------------------------------- 235
WGQ +++ L RY P E L +
Sbjct: 234 WGQVVIISMLTRYARTQFLSPTQNESLLEENAEKAFYGSEEDEAKGAGSEETAAAAAPSR 293
Query: 236 -----------ILNLLDSFLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAA 284
+L L+S S VVM +L+ LA P + V+ + LL +
Sbjct: 294 KPYVMDPDHRLLLRNTKPLLQSRSAAVVMAVAQLYFHLA---PKAEVGVIAKALVRLLRS 350
Query: 285 CSSESRELCFVALCHVRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDEN 344
S E+ +V L +V + G F + K F+ ++P IK+ K+EVL L N+ N
Sbjct: 351 HS----EVQYVVLQNVATMSIKRRGMFEPYLKSFYIRSTDPTQIKILKLEVLTNLANETN 406
Query: 345 VQQVLEELRGYCTDVSADFAQAAIFAIGGIART---YTDQCVQILTELLGLRQEHITTVV 401
+ VL E + Y + DF A I AIG A D C+ L +LL R E +
Sbjct: 407 IPTVLREFQTYIRSMDKDFVAATIQAIGRCATNIGRVRDTCLNGLVQLLSNRDELVVAES 466
Query: 402 VQTFRDLVWLCPQCTEAVCQALPGCEENIQDSEGKQALIWLLGVHGERIPN-APYVLEDF 460
V + L+ + P + + L +NIQ + +++WL+G + E +P AP VL
Sbjct: 467 VVVIKKLLQMQPAQHGEIIKHLAKLTDNIQVPMARASILWLIGEYCEHVPRIAPDVLRKM 526
Query: 461 VENVKSETFPAVKMELLTALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYR 520
++ +E VK++++ +L+L+ + + +L + + + +++ +RDR F +
Sbjct: 527 AKSFTAEE-DIVKLQVINLAAKLYLTNSKQTK-LLTQYVLSLAKYDQNYDIRDRARFTRQ 584
Query: 521 LLLVGID------EVKRILCSPKSDPTL 542
L++ K++ +PK P L
Sbjct: 585 LIVPSEQGGALSRHAKKLFLAPKPAPVL 612
>gi|32484979 adaptor-related protein complex 3, beta 1 subunit [Homo
sapiens]
Length = 1094
Score = 165 bits (418), Expect = 1e-40
Identities = 138/559 (24%), Positives = 259/559 (46%), Gaps = 50/559 (8%)
Query: 31 NVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINTL 90
+ ++R++ + +G + S +F +VK A+ +I KKLVY+Y+ YA + DLALL+I+T
Sbjct: 61 DAMKRIVGMIAKGKNASELFPAVVKNVASKNIEIKKLVYVYLVRYAEEQQDLALLSISTF 120
Query: 91 CKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHNL 150
+ DPN ++R ALR + S+R+P + + I D + YVR+ A K+++L
Sbjct: 121 QRALKDPNQLIRASALRVLSSIRVPIIVPIMMLAIKEASADLSPYVRKNAAHAIQKLYSL 180
Query: 151 HGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKL 210
D E L+ + LL+D+ +V + + + EE+ ++ L N + +
Sbjct: 181 --DPEQKEMLIEVIEKLLKDKSTLVAGSVVMAFEEVCPDRIDLIHKN--YRKLCNLLVDV 236
Query: 211 DQWGQAEVLNFLLRY------QPRSE-EELFDI-LNLLDS-------------------- 242
++WGQ +++ L RY P E +EL D N +S
Sbjct: 237 EEWGQVVIIHMLTRYARTQFVSPWKEGDELEDNGKNFYESDDDQKEKTDKKKKPYTMDPD 296
Query: 243 ---FLKSSSPGVVMGATKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCH 299
++++ P + + + +A+++ H+ + L +RE+ ++ L +
Sbjct: 297 HRLLIRNTKPLLQSRNAAVVMAVAQLYWHISPKSEAGIISKSLVRLLRSNREVQYIVLQN 356
Query: 300 VRQILHSLPGHFSSHYKKFFCSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYCTDV 359
+ + G F + K F+ ++P IK K+E+L L N+ N+ +L E + Y
Sbjct: 357 IATMSIQRKGMFEPYLKSFYVRSTDPTMIKTLKLEILTNLANEANISTLLREFQTYVKSQ 416
Query: 360 SADFAQAAIFAIGGIART---YTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCT 416
FA A I IG A TD C+ L LL R E + V + L+ + P
Sbjct: 417 DKQFAAATIQTIGRCATNILEVTDTCLNGLVCLLSNRDEIVVAESVVVIKKLLQMQPAQH 476
Query: 417 EAVCQALPGCEENIQDSEGKQALIWLLGVHGERIPN-APYVLEDFVENVKSETFPAVKME 475
+ + + ++I + +++WL+G + ER+P AP VL ++ SE VK++
Sbjct: 477 GEIIKHMAKLLDSITVPVARASILWLIGENCERVPKIAPDVLRKMAKSFTSED-DLVKLQ 535
Query: 476 LLTALLRLFLSRPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLLLVGIDE------V 529
+L +L+L+ + + +L + + + +++ +RDR F +L++ +
Sbjct: 536 ILNLGAKLYLTNSKQTK-LLTQYILNLGKYDQNYDIRDRTRFIRQLIVPNVKSGALSKYA 594
Query: 530 KRILCSPKSDPTLGLLEDP 548
K+I + K P LLE P
Sbjct: 595 KKIFLAQKPAP---LLESP 610
>gi|109134349 coatomer protein complex, subunit gamma 2 [Homo
sapiens]
Length = 871
Score = 68.2 bits (165), Expect = 3e-11
Identities = 99/514 (19%), Positives = 217/514 (42%), Gaps = 40/514 (7%)
Query: 28 RYRNVIQRVIRYMTQG-----LDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDL 82
R +++ +++ + QG + + F M + + D +++ YL + A + D+
Sbjct: 43 RCLHILTKILYLLNQGEHFGTTEATEAFFAMTRLFQSNDQTLRRMCYLTIKEMATISEDV 102
Query: 83 ALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVL 142
++ ++L KD + + RG A+R++C + + + I++ + + DK S V A++
Sbjct: 103 -IIVTSSLTKDMTGKEDVYRGPAIRALCRITDGTMLQAIERYMKQAIVDKVSSVSSSALV 161
Query: 143 GCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHH 202
+ +H + +V +NE + +V + L L + K + + ++K
Sbjct: 162 --SSLHMMKISYDVVKRWINEAQEAASSDNIMVQYHALGVLYHLRKND-RLAVSK----- 213
Query: 203 LLNRMSKLDQWGQAEVLNFLLRYQPRSEEELFD-----ILNLLDSFLKSSSPGVVMGATK 257
+LN+ +K Q L+R R +E D + + ++S L++ V+ A
Sbjct: 214 MLNKFTKSGLKSQFAYC-MLIRIASRLLKETEDGHESPLFDFIESCLRNKHEMVIYEAAS 272
Query: 258 LFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHYKK 317
+ L P+ L L CSS L + A+ + ++ P ++
Sbjct: 273 AIIHL----PNCTARELAPAVSVLQLFCSSPKPALRYAAVRTLNKVAMKHPSAVTACNLD 328
Query: 318 FFCSYSEPH-YIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIFAIGGIAR 376
++ + I + L + ++ +V ++++++ + +++S +F + AI + +
Sbjct: 329 LENLITDSNRSIATLAITTLLKTGSESSVDRLMKQISSFVSEISDEFKVVVVQAISALCQ 388
Query: 377 TYTDQCVQILTELLGLRQE----HITTVVVQTFRDLVWLCPQCTEA----VCQALPGCEE 428
Y + ++T L + ++ +V +V P+ EA +C+ + CE
Sbjct: 389 KYPRKHSVMMTFLSNMLRDDGGFEYKRAIVDCIISIVEENPESKEAGLAHLCEFIEDCEH 448
Query: 429 NIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRLFLSRP 488
+ ++ ++ LLG G R P P F+ N AV+ ++AL +
Sbjct: 449 TVLATK----ILHLLGKEGPRTP-VPSKYIRFIFNRVVLENEAVRAAAVSALAKFGAQNE 503
Query: 489 AECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLL 522
+ +L LL C+ + D VRDR FY +L
Sbjct: 504 SLLPSIL-VLLQRCMMDTDD-EVRDRATFYLNVL 535
>gi|11559929 coatomer protein complex, subunit gamma 1 [Homo
sapiens]
Length = 874
Score = 56.6 bits (135), Expect = 8e-08
Identities = 98/516 (18%), Positives = 211/516 (40%), Gaps = 50/516 (9%)
Query: 31 NVIQRVIRYMTQG-----LDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALL 85
+++ +++ + QG + + F M K + D +++ YL + + + D+ ++
Sbjct: 46 HILTKILYLINQGEHLGTTEATEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDV-II 104
Query: 86 AINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCA 145
++L KD + RG A+R++C + + + I++ + + DK V A++ +
Sbjct: 105 VTSSLTKDMTGKEDNYRGPAVRALCQITDSTMLQAIERYMKQAIVDKVPSVSSSALV--S 162
Query: 146 KMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLN 205
+H L +V VNE + +V + L L + K + + +NK I
Sbjct: 163 SLHLLKCSFDVVKRWVNEAQEAASSDNIMVQYHALGLLYHVRKND-RLAVNKMI------ 215
Query: 206 RMSKLDQWGQAEVLNFLLRYQPRS---EEE-------LFDILNLLDSFLKSSSPGVVMGA 255
SK+ + G + + + S EEE LFD ++S L++ VV A
Sbjct: 216 --SKVTRHGLKSPFAYCMMIRVASKQLEEEDGSRDSPLFD---FIESCLRNKHEMVVYEA 270
Query: 256 TKLFLILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHY 315
+ L P L L CSS L + A+ + ++ P ++
Sbjct: 271 ASAIVNL----PGCSAKELAPAVSVLQLFCSSPKAALRYAAVRTLNKVAMKHPSAVTACN 326
Query: 316 KKFFCSYSEPH-YIKLQKVEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIFAIGGI 374
++ + I + L + ++ ++ ++++++ + +++S +F + AI +
Sbjct: 327 LDLENLVTDSNRSIATLAITTLLKTGSESSIDRLMKQISSFMSEISDEFKVVVVQAISAL 386
Query: 375 ARTYTDQCVQILTELLGLRQE----HITTVVVQTFRDLVWLCPQCTEA----VCQALPGC 426
+ Y + ++ L + +E +V ++ + E +C+ + C
Sbjct: 387 CQKYPRKHAVLMNFLFTMLREEGGFEYKRAIVDCIISIIEENSESKETGLSHLCEFIEDC 446
Query: 427 EENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLTALLRLFLS 486
E + + ++ LLG G + N P F+ N V+ ++AL + F +
Sbjct: 447 EFTVLATR----ILHLLGQEGPKTTN-PSKYIRFIYNRVVLEHEEVRAGAVSALAK-FGA 500
Query: 487 RPAECQDMLGRLLYYCIEEEKDMAVRDRGLFYYRLL 522
+ E + LL C+ ++ D VRDR FY +L
Sbjct: 501 QNEEMLPSILVLLKRCVMDD-DNEVRDRATFYLNVL 535
>gi|4503843 adaptor-related protein complex 1, gamma 2 subunit [Homo
sapiens]
Length = 785
Score = 51.2 bits (121), Expect = 3e-06
Identities = 91/433 (21%), Positives = 165/433 (38%), Gaps = 50/433 (11%)
Query: 51 MEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLAL---- 106
ME +K A+ K++ YL + D LL N++ D S V+GLAL
Sbjct: 69 MECLKLIASSRFTDKRVGYLGAMLLLDERHDAHLLITNSIKNDLSQGIQPVQGLALCTLS 128
Query: 107 ----RSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVN 162
MC P V++ + QP + YVR+ A+L +H + E+ +
Sbjct: 129 TMGSAEMCRDLAPEVEKLLLQP--------SPYVRKKAIL--TAVHMIRKVPELSSVFLP 178
Query: 163 ELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVIN----KPIAHHLLNRMSKL-------- 210
LL ++ +++ + + E+ ++ + + P H+L + +
Sbjct: 179 PCAQLLHERHHGILLGTITLITELCERSPAALRHFRKVVPQLVHILRTLVTMGYSTEHSI 238
Query: 211 ----DQWGQAEVLNFLLRYQPRSEEELFDILN-LLDSFLKSSSPGVVMGATKLF-LILAK 264
D + Q ++L LLR R+ EE + +N LL ++ G LF +L
Sbjct: 239 SGVSDPFLQVQILR-LLRILGRNHEESSETMNDLLAQVATNTDTSRNAGNAVLFETVLTI 297
Query: 265 MFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGHFSSHYKKFF-CSYS 323
M + V L + R + +VAL + +++ S H C
Sbjct: 298 MDIRSAAGLRVLAVNILGRFLLNSDRNIRYVALTSLLRLVQSDHSAVQRHRPTVVECLRE 357
Query: 324 EPHYIKLQKVEVLCELVNDENVQQVLEELRGYC----TDVSADFAQAAIFAIGGIA---R 376
+ + +E+ LVN NV+ +++EL+ + D+ AD A + A A R
Sbjct: 358 TDASLSRRALELSLALVNSSNVRAMMQELQAFLESCPPDLRADCASGILLAAERFAPTKR 417
Query: 377 TYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQC-TEAVCQALPGCEENIQDSEG 435
+ D + +LT H+ V L+ + +V + E+I
Sbjct: 418 WHIDTILHVLT----TAGTHVRDDAVANLTQLIGGAQELHAYSVRRLYNALAEDISQQPL 473
Query: 436 KQALIWLLGVHGE 448
Q W +G +G+
Sbjct: 474 VQVAAWCIGEYGD 486
>gi|117553580 adaptor-related protein complex 3, delta 1 subunit
isoform 2 [Homo sapiens]
Length = 1153
Score = 48.5 bits (114), Expect = 2e-05
Identities = 69/350 (19%), Positives = 144/350 (41%), Gaps = 16/350 (4%)
Query: 10 VKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVY 69
+ E+K+ L +I N + ++ G D+S +++ + K++ Y
Sbjct: 40 IDEIKQELKQDNIAVKA----NAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGY 95
Query: 70 LYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGL 129
L D+ +L N + KD S P+ G+AL + P + + I+ +
Sbjct: 96 LAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLM 155
Query: 130 RDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQ 189
Y+R+ AVL K+ + +S L L D DP V + + E+ ++
Sbjct: 156 SHTKPYIRKKAVLIMYKVFLKYPESL--RPAFPRLKEKLEDPDPGVQSAAVNVICELARR 213
Query: 190 EGGVVIN-KPIAHHLLNRMSKLDQWGQAEVLNF---LLRYQPRSEEELFD-ILNLLDSFL 244
++ P+ L+ S + W +++ L +PR ++L + + NL+ S
Sbjct: 214 NPKNYLSLAPLFFKLMT--SSTNNWVLIKIIKLFGALTPLEPRLGKKLIEPLTNLIHSTS 271
Query: 245 KSSSPGVVMGATKLFLI-LAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQI 303
S + LI L+ P+ + + V+ L + L ++ L + +I
Sbjct: 272 AMSLLYECVNTVIAVLISLSSGMPNHSASIQLCVQ-KLRILIEDSDQNLKYLGLLAMSKI 330
Query: 304 LHSLPGHFSSHYKKFF-CSYSEPHYIKLQKVEVLCELVNDENVQQVLEEL 352
L + P SH C + I+L+ +++L +V+ +N+ +++++L
Sbjct: 331 LKTHPKSVQSHKDLILQCLDDKDESIRLRALDLLYGMVSKKNLMEIVKKL 380
>gi|221316632 coatomer protein complex, subunit beta 1 [Homo
sapiens]
Length = 953
Score = 43.9 bits (102), Expect = 5e-04
Identities = 34/116 (29%), Positives = 54/116 (46%), Gaps = 6/116 (5%)
Query: 33 IQRVIRYMTQGLDMSGVFMEMVKASATV-DIVQKKLVYLYMCTYAPLKPDLALL-----A 86
+++VI + G + G+ M +++ + D KKL+ ++ PD LL
Sbjct: 42 LKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILV 101
Query: 87 INTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVL 142
+ KD PN +RG LR +C L+ + E + I L + SYVRR AVL
Sbjct: 102 CDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVL 157
>gi|221316630 coatomer protein complex, subunit beta 1 [Homo
sapiens]
Length = 953
Score = 43.9 bits (102), Expect = 5e-04
Identities = 34/116 (29%), Positives = 54/116 (46%), Gaps = 6/116 (5%)
Query: 33 IQRVIRYMTQGLDMSGVFMEMVKASATV-DIVQKKLVYLYMCTYAPLKPDLALL-----A 86
+++VI + G + G+ M +++ + D KKL+ ++ PD LL
Sbjct: 42 LKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILV 101
Query: 87 INTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVL 142
+ KD PN +RG LR +C L+ + E + I L + SYVRR AVL
Sbjct: 102 CDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVL 157
>gi|7705369 coatomer protein complex, subunit beta 1 [Homo sapiens]
Length = 953
Score = 43.9 bits (102), Expect = 5e-04
Identities = 34/116 (29%), Positives = 54/116 (46%), Gaps = 6/116 (5%)
Query: 33 IQRVIRYMTQGLDMSGVFMEMVKASATV-DIVQKKLVYLYMCTYAPLKPDLALL-----A 86
+++VI + G + G+ M +++ + D KKL+ ++ PD LL
Sbjct: 42 LKKVIIMILNGEKLPGLLMTIIRFVLPLQDHTIKKLLLVFWEIVPKTTPDGRLLHEMILV 101
Query: 87 INTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGLRDKASYVRRVAVL 142
+ KD PN +RG LR +C L+ + E + I L + SYVRR AVL
Sbjct: 102 CDAYRKDLQHPNEFIRGSTLRFLCKLKEAELLEPLMPAIRACLEHRHSYVRRNAVL 157
>gi|71773010 adaptor-related protein complex 1, gamma 1 subunit
isoform a [Homo sapiens]
Length = 825
Score = 41.6 bits (96), Expect = 0.003
Identities = 93/483 (19%), Positives = 194/483 (40%), Gaps = 42/483 (8%)
Query: 28 RYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAI 87
R RNV + + +M G +E +K A+ K++ YL + D+ LL
Sbjct: 46 RCRNVAKLLYMHML-GYPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMT 104
Query: 88 NTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQ---PILNGLRDKASYVRRVAVLGC 144
N + D + V+GLAL C+L G E + + L+ SY+R+ A L C
Sbjct: 105 NCIKNDLNHSTQFVQGLAL---CTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAAL-C 160
Query: 145 AKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVI----NKPIA 200
A +H + E+ + +LL +++ V+ + L E+ ++ ++ N+ +
Sbjct: 161 A-VHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFRKNEKLV 219
Query: 201 HHLLNRMSKL---------------DQWGQAEVLNFLLRYQPRSEEELFDILN-LLDSFL 244
L+ + L D + Q +L LLR R++++ + +N +L
Sbjct: 220 PQLVRILKNLIMSGYSPEHDVSGISDPFLQVRILR-LLRILGRNDDDSSEAMNDILAQVA 278
Query: 245 KSSSPGVVMGATKLF-LILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQI 303
++ +G L+ +L M ++ + V L + + + +VAL + +
Sbjct: 279 TNTETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKT 338
Query: 304 LHSLPGHFSSHYKKFF-CSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYC----TD 358
+ + H C IK + +E+ LVN N++ +++EL + +
Sbjct: 339 VQTDHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPE 398
Query: 359 VSADFAQAAIFAIGGIA---RTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQC 415
AD A A A R + D +++LT ++ ++Q + V +
Sbjct: 399 FKADCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYT 458
Query: 416 TEAVCQALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKME 475
+ + +A+ G + Q W +G +G+ + + E+ ++ + E ++
Sbjct: 459 VQRLYKAILG---DYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDILESV 515
Query: 476 LLT 478
L++
Sbjct: 516 LIS 518
>gi|71772942 adaptor-related protein complex 1, gamma 1 subunit
isoform b [Homo sapiens]
Length = 822
Score = 41.2 bits (95), Expect = 0.004
Identities = 92/480 (19%), Positives = 194/480 (40%), Gaps = 39/480 (8%)
Query: 28 RYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVYLYMCTYAPLKPDLALLAI 87
R RNV + + +M G +E +K A+ K++ YL + D+ LL
Sbjct: 46 RCRNVAKLLYMHML-GYPAHFGQLECLKLIASQKFTDKRIGYLGAMLLLDERQDVHLLMT 104
Query: 88 NTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQ---PILNGLRDKASYVRRVAVLGC 144
N + D + V+GLAL C+L G E + + L+ SY+R+ A L C
Sbjct: 105 NCIKNDLNHSTQFVQGLAL---CTLGCMGSSEMCRDLAGEVEKLLKTSNSYLRKKAAL-C 160
Query: 145 AKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQEGGVVIN-KPIAHHL 203
A +H + E+ + +LL +++ V+ + L E+ ++ ++ + + + L
Sbjct: 161 A-VHVIRKVPELMEMFLPATKNLLNEKNHGVLHTSVVLLTEMCERSPDMLAHFRKLVPQL 219
Query: 204 LNRMSKL---------------DQWGQAEVLNFLLRYQPRSEEELFDILN-LLDSFLKSS 247
+ + L D + Q +L LLR R++++ + +N +L ++
Sbjct: 220 VRILKNLIMSGYSPEHDVSGISDPFLQVRILR-LLRILGRNDDDSSEAMNDILAQVATNT 278
Query: 248 SPGVVMGATKLF-LILAKMFPHVQTDVLVRVKGPLLAACSSESRELCFVALCHVRQILHS 306
+G L+ +L M ++ + V L + + + +VAL + + + +
Sbjct: 279 ETSKNVGNAILYETVLTIMDIKSESGLRVLAINILGRFLLNNDKNIRYVALTSLLKTVQT 338
Query: 307 LPGHFSSHYKKFF-CSYSEPHYIKLQKVEVLCELVNDENVQQVLEELRGYC----TDVSA 361
H C IK + +E+ LVN N++ +++EL + + A
Sbjct: 339 DHNAVQRHRSTIVDCLKDLDVSIKRRAMELSFALVNGNNIRGMMKELLYFLDSCEPEFKA 398
Query: 362 DFAQAAIFAIGGIA---RTYTDQCVQILTELLGLRQEHITTVVVQTFRDLVWLCPQCTEA 418
D A A A R + D +++LT ++ ++Q + V + +
Sbjct: 399 DCASGIFLAAEKYAPSKRWHIDTIMRVLTTAGSYVRDDAVPNLIQLITNSVEMHAYTVQR 458
Query: 419 VCQALPGCEENIQDSEGKQALIWLLGVHGERIPNAPYVLEDFVENVKSETFPAVKMELLT 478
+ +A+ G + Q W +G +G+ + + E+ ++ + E ++ L++
Sbjct: 459 LYKAILG---DYSQQPLVQVAAWCIGEYGDLLVSGQCEEEEPIQVTEDEVLDILESVLIS 515
>gi|27477041 adaptor-related protein complex 2, alpha 2 subunit
[Homo sapiens]
Length = 939
Score = 40.8 bits (94), Expect = 0.005
Identities = 100/497 (20%), Positives = 180/497 (36%), Gaps = 58/497 (11%)
Query: 7 EDVVKELKKALCNPHIQ------ADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV 60
E +K + K L N + D + + +++ G D+ ME V ++
Sbjct: 27 EAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSN 86
Query: 61 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEY 120
+K++ YL++ +L L N + D + NP GLAL + S+ + E
Sbjct: 87 RYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMGLALHCIASVGSREMAEA 146
Query: 121 IQQPILNGL--RDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVVVN 178
I L D V++ A L +++ D G + + LL DQ + VV
Sbjct: 147 FAGEIPKVLVAGDTMDSVKQSAALCLLRLYRTSPDLVPMGDWTSRVVHLLNDQH-LGVVT 205
Query: 179 CLRSLEEILKQEGGVVINKPIAHHLLNRMSKL-----------------DQWGQAEVLNF 221
SL L Q+ ++ ++R+S++ W ++L
Sbjct: 206 AATSLITTLAQKNPEEFKTSVS-LAVSRLSRIVTSASTDLQDYTYYFVPAPWLSVKLLRL 264
Query: 222 LLRYQP-------RSEEELFDILNLLDSFLKSSSPGVVMGATK---LFLILAKMFPH-VQ 270
L Y P R E L ILN KS V K LF ++ + H +
Sbjct: 265 LQCYPPPDPAVRGRLTECLETILNKAQEPPKSKK--VQHSNAKNAVLFEAISLIIHHDSE 322
Query: 271 TDVLVRVKGPLLAACSSESRELCFVALCHVRQILHSLPGH--FSSHYKKFFCSYSEPHYI 328
++LVR L L ++AL + + S H +H + + +
Sbjct: 323 PNLLVRACNQLGQFLQHRETNLRYLALESMCTLASSEFSHEAVKTHIETVINALKTERDV 382
Query: 329 KLQK--VEVLCELVNDENVQQVLEELRGYCTDVSADFAQAAIFAIGGIARTYTDQCVQIL 386
+++ V++L + + N Q++ E+ Y + + + +A Y +
Sbjct: 383 SVRQRAVDLLYAMCDRSNAPQIVAEMLSYLETADYSIREEIVLKVAILAEKYAVDYTWYV 442
Query: 387 TELLGLRQ-------EHITTVVVQTFRDLVWLCPQCTEAVCQAL--PGCEENIQDSEGKQ 437
+L L + E + V+Q + + + V +AL P C EN+ G
Sbjct: 443 DTILNLIRIAGDYVSEEVWYRVIQIVINRDDVQGYAAKTVFEALQAPACHENLVKVGG-- 500
Query: 438 ALIWLLGVHGERIPNAP 454
++LG G I P
Sbjct: 501 ---YILGEFGNLIAGDP 514
>gi|117553584 adaptor-related protein complex 3, delta 1 subunit
isoform 1 [Homo sapiens]
Length = 1112
Score = 34.7 bits (78), Expect = 0.33
Identities = 27/133 (20%), Positives = 53/133 (39%), Gaps = 4/133 (3%)
Query: 10 VKELKKALCNPHIQADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATVDIVQKKLVY 69
+ E+K+ L +I N + ++ G D+S +++ + K++ Y
Sbjct: 40 IDEIKQELKQDNIAVKA----NAVCKLTYLQMLGYDISWAAFNIIEVMSASKFTFKRIGY 95
Query: 70 LYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPGVQEYIQQPILNGL 129
L D+ +L N + KD S P+ G+AL + P + + I+ +
Sbjct: 96 LAASQSFHEGTDVIMLTTNQIRKDLSSPSQYDTGVALTGLSCFVTPDLARDLANDIMTLM 155
Query: 130 RDKASYVRRVAVL 142
Y+R+ A L
Sbjct: 156 SHTKPYIRKKAKL 168
>gi|54792082 phosphoinositide-3-kinase, catalytic, alpha polypeptide
[Homo sapiens]
Length = 1068
Score = 32.3 bits (72), Expect = 1.6
Identities = 15/42 (35%), Positives = 26/42 (61%), Gaps = 5/42 (11%)
Query: 68 VYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSM 109
+Y + + P+KP+ A+ + DC+ P+PMVRG A+R +
Sbjct: 583 MYCLVKDWPPIKPEQAMELL-----DCNYPDPMVRGFAVRCL 619
>gi|27734755 F-box and leucine-rich repeat protein 20 [Homo sapiens]
Length = 436
Score = 32.3 bits (72), Expect = 1.6
Identities = 26/95 (27%), Positives = 41/95 (43%), Gaps = 10/95 (10%)
Query: 348 VLEELR-GYCTDVSADFAQAAIFAIGGIARTYTDQCVQILTELL---GLRQEHITTVVVQ 403
+LE+L +C V+ D QA + GG+ + C Q+ E L G + T+ +Q
Sbjct: 170 LLEQLNISWCDQVTKDGIQALVRGCGGLKALFLKGCTQLEDEALKYIGAHCPELVTLNLQ 229
Query: 404 TF-----RDLVWLCPQCTEAVCQALPGCEENIQDS 433
T L+ +C C + GC NI D+
Sbjct: 230 TCLQITDEGLITICRGCHKLQSLCASGC-SNITDA 263
>gi|214010165 rab11-family interacting protein 3 isoform 2 [Homo
sapiens]
Length = 460
Score = 31.2 bits (69), Expect = 3.6
Identities = 17/40 (42%), Positives = 26/40 (65%), Gaps = 2/40 (5%)
Query: 586 PEL-PKTSSFAASGPLIPEENKERVQELPDSGALMLVPNR 624
PEL P+ + +A G +P E + ++E PD GAL+L+P R
Sbjct: 38 PELQPEGDADSAGGSAVPSECLDAMEE-PDHGALLLLPGR 76
>gi|7662234 rab11-family interacting protein 3 isoform 1 [Homo
sapiens]
Length = 756
Score = 31.2 bits (69), Expect = 3.6
Identities = 17/40 (42%), Positives = 26/40 (65%), Gaps = 2/40 (5%)
Query: 586 PEL-PKTSSFAASGPLIPEENKERVQELPDSGALMLVPNR 624
PEL P+ + +A G +P E + ++E PD GAL+L+P R
Sbjct: 334 PELQPEGDADSAGGSAVPSECLDAMEE-PDHGALLLLPGR 372
>gi|45331213 RAN binding protein 6 [Homo sapiens]
Length = 1105
Score = 31.2 bits (69), Expect = 3.6
Identities = 37/146 (25%), Positives = 56/146 (38%), Gaps = 33/146 (22%)
Query: 119 EYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLL---------- 168
EY + P+L +RD VR+ A G M GD +L +E LL
Sbjct: 912 EYFRWPMLLNMRDNNPEVRQAAAYGLGVMAQFGGDDY--RSLCSEAVPLLVKVIKCANSK 969
Query: 169 RDQDPIVVVNCLRSLEEILKQEGGVVINKPIAHHLLNRMSKLDQWGQAEVLNFLLRYQPR 228
++ I NC+ ++ +ILK + V EVL L + P
Sbjct: 970 TKKNVIATENCISAIGKILKFKPNCV-------------------NVDEVLPHWLSWLPL 1010
Query: 229 SE--EELFDILNLLDSFLKSSSPGVV 252
E EE L+ L ++S+ P V+
Sbjct: 1011 HEDKEEAIQTLSFLCDLIESNHPVVI 1036
>gi|19913414 adaptor-related protein complex 2, alpha 1 subunit
isoform 1 [Homo sapiens]
Length = 977
Score = 31.2 bits (69), Expect = 3.6
Identities = 38/178 (21%), Positives = 67/178 (37%), Gaps = 8/178 (4%)
Query: 7 EDVVKELKKALCNPHIQ------ADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV 60
E +K + K L N + D + + +++ G D+ ME V ++
Sbjct: 27 EAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSN 86
Query: 61 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSL--RMPGVQ 118
+K++ YL++ +L L N + D + NP LAL + ++ R G
Sbjct: 87 KYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEA 146
Query: 119 EYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVV 176
P + D V++ A L +++ D G + LL DQ VV
Sbjct: 147 FAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVV 204
>gi|19913416 adaptor-related protein complex 2, alpha 1 subunit
isoform 2 [Homo sapiens]
Length = 955
Score = 31.2 bits (69), Expect = 3.6
Identities = 38/178 (21%), Positives = 67/178 (37%), Gaps = 8/178 (4%)
Query: 7 EDVVKELKKALCNPHIQ------ADRLRYRNVIQRVIRYMTQGLDMSGVFMEMVKASATV 60
E +K + K L N + D + + +++ G D+ ME V ++
Sbjct: 27 EAEIKRINKELANIRSKFKGDKALDGYSKKKYVCKLLFIFLLGHDIDFGHMEAVNLLSSN 86
Query: 61 DIVQKKLVYLYMCTYAPLKPDLALLAINTLCKDCSDPNPMVRGLALRSMCSL--RMPGVQ 118
+K++ YL++ +L L N + D + NP LAL + ++ R G
Sbjct: 87 KYTEKQIGYLFISVLVNSNSELIRLINNAIKNDLASRNPTFMCLALHCIANVGSREMGEA 146
Query: 119 EYIQQPILNGLRDKASYVRRVAVLGCAKMHNLHGDSEVDGALVNELYSLLRDQDPIVV 176
P + D V++ A L +++ D G + LL DQ VV
Sbjct: 147 FAADIPRILVAGDSMDSVKQSAALCLLRLYKASPDLVPMGEWTARVVHLLNDQHMGVV 204
>gi|109715835 HEAT repeat containing 6 [Homo sapiens]
Length = 1181
Score = 31.2 bits (69), Expect = 3.6
Identities = 15/65 (23%), Positives = 38/65 (58%), Gaps = 2/65 (3%)
Query: 58 ATVDIVQKKLVYLYMCTYAPLKPDL-ALLAINTLCKDCSDPNPMVRGLALRSMCSLRMPG 116
+T+ ++KK++Y Y + P P+L + +++ + DP+P R AL+ + ++ + G
Sbjct: 429 STIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQVLSAI-LEG 487
Query: 117 VQEYI 121
++++
Sbjct: 488 SKQFL 492
>gi|153266841 apolipoprotein H precursor [Homo sapiens]
Length = 345
Score = 30.8 bits (68), Expect = 4.7
Identities = 28/99 (28%), Positives = 43/99 (43%), Gaps = 10/99 (10%)
Query: 523 LVGIDEVKRILCSPKSDPTLGLLEDPAERPV-----NSWASDFNTLVPVYGKAHWATISK 577
L G+ + + C+P+ P G+LE+ A R N+ + NT + G A +K
Sbjct: 68 LTGLWPINTLKCTPRVCPFAGILENGAVRYTTFEYPNTISFSCNTGFYLNG----ADSAK 123
Query: 578 CQGAERCDPELPKTSSFAASGPLIPEENKERVQELPDSG 616
C + PELP + P IP RV + P +G
Sbjct: 124 CTEEGKWSPELPVCAPIICPPPSIPTFATLRVYK-PSAG 161
>gi|55742730 storkhead box 2 [Homo sapiens]
Length = 926
Score = 30.8 bits (68), Expect = 4.7
Identities = 33/105 (31%), Positives = 43/105 (40%), Gaps = 10/105 (9%)
Query: 536 PKSDPTLGLLEDPAE-------RPVNSWASDFNTLVPVYGKA-HWATISKCQGAERCDPE 587
P +LG ED AE P S+ D +TL P + A IS E C PE
Sbjct: 500 PLGASSLGTPEDLAEGCSQDDQTPSQSYIDD-STLRPAQTVSLQRAHISSTSYKEVCIPE 558
Query: 588 LPKTSSFAASGPLIPEENKERVQELPDSGALMLVPNRQLTADYFE 632
+ S +S + E K + LP G L P + T DYF+
Sbjct: 559 IVSGSKEPSSACSLLEPGKPP-ESLPSYGELNSCPTKTATDDYFQ 602
>gi|4504811 junction plakoglobin [Homo sapiens]
Length = 745
Score = 30.4 bits (67), Expect = 6.2
Identities = 14/42 (33%), Positives = 23/42 (54%)
Query: 149 NLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQE 190
N D+E+ + EL LL D+DP+VV + ++ K+E
Sbjct: 132 NYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKE 173
>gi|12056468 junction plakoglobin [Homo sapiens]
Length = 745
Score = 30.4 bits (67), Expect = 6.2
Identities = 14/42 (33%), Positives = 23/42 (54%)
Query: 149 NLHGDSEVDGALVNELYSLLRDQDPIVVVNCLRSLEEILKQE 190
N D+E+ + EL LL D+DP+VV + ++ K+E
Sbjct: 132 NYQDDAELATRALPELTKLLNDEDPVVVTKAAMIVNQLSKKE 173
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,543,951
Number of Sequences: 37866
Number of extensions: 1209637
Number of successful extensions: 3039
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 15
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2981
Number of HSP's gapped (non-prelim): 51
length of query: 739
length of database: 18,247,518
effective HSP length: 110
effective length of query: 629
effective length of database: 14,082,258
effective search space: 8857740282
effective search space used: 8857740282
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.