Search of human proteins with 16507950

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16507950 tektin 2 [Homo sapiens]
         (430 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16507950 tektin 2 [Homo sapiens]                                   845   0.0  
gi|16753231 tektin 1 [Homo sapiens]                                   211   1e-54
gi|13994250 tektin 3 [Homo sapiens]                                   191   8e-49
gi|21389613 tektin 4 [Homo sapiens]                                   189   3e-48
gi|21389569 tektin 5 [Homo sapiens]                                   164   2e-40
gi|239747088 PREDICTED: MAFF interacting protein [Homo sapiens]       155   5e-38
gi|239747014 PREDICTED: similar to tektin 4 [Homo sapiens]             82   7e-16
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    67   4e-11
gi|31982906 cingulin-like 1 [Homo sapiens]                             60   5e-09
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             56   6e-08
gi|210032790 hypothetical protein LOC27146 [Homo sapiens]              55   9e-08
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap...    55   2e-07
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap...    55   2e-07
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap...    55   2e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     54   2e-07
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              54   3e-07
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         54   4e-07
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    53   5e-07
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s...    52   1e-06
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        52   1e-06
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        52   1e-06
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         52   1e-06
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         52   1e-06
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         52   1e-06
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         52   1e-06
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         52   1e-06
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         52   1e-06
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       51   2e-06
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    50   5e-06
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    50   5e-06

>gi|16507950 tektin 2 [Homo sapiens]
          Length = 430

 Score =  845 bits (2183), Expect = 0.0
 Identities = 430/430 (100%), Positives = 430/430 (100%)

Query: 1   MATLSVKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN 60
           MATLSVKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN
Sbjct: 1   MATLSVKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN 60

Query: 61  RTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLR 120
           RTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLR
Sbjct: 61  RTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLR 120

Query: 121 ESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKM 180
           ESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKM
Sbjct: 121 ESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKM 180

Query: 181 ETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELR 240
           ETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELR
Sbjct: 181 ETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELR 240

Query: 241 EATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHL 300
           EATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHL
Sbjct: 241 EATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHL 300

Query: 301 EEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQ 360
           EEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQ
Sbjct: 301 EEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQ 360

Query: 361 DALDALCKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAERFVPEVDTFTRTTNSTLS 420
           DALDALCKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAERFVPEVDTFTRTTNSTLS
Sbjct: 361 DALDALCKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAERFVPEVDTFTRTTNSTLS 420

Query: 421 PLKSCQLELA 430
           PLKSCQLELA
Sbjct: 421 PLKSCQLELA 430


>gi|16753231 tektin 1 [Homo sapiens]
          Length = 418

 Score =  211 bits (536), Expect = 1e-54
 Identities = 131/393 (33%), Positives = 202/393 (51%), Gaps = 1/393 (0%)

Query: 6   VKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLV 65
           ++P  +F   +WH  +      A  QR  S ++  E++ L +E    T   + D   +L 
Sbjct: 5   LQPPPKFLPSEWHIANKNQYHRADAQRSRSERLVAESQRLVDEIEKTTRKSQSDVNKKLE 64

Query: 66  ERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRD 125
           +R++ V  WK+ LD  L  L    D L   K   E+ L+    PL +   CL  RE R  
Sbjct: 65  QRLEEVQFWKKELDDKLEQLVNVTDDLLIYKIRLEKALETLKEPLHITETCLAYREKRIG 124

Query: 126 IDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEI 185
           ID+V D VE EL KE E+I+     L + + +A EQ+ + +  +  L  D + K   L I
Sbjct: 125 IDLVHDTVEHELIKEAEIIQGIMALLTRTLEEASEQIRMNRSAKYNLEKDLKDKFVALTI 184

Query: 186 DRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATAL 245
           D  C SLN  SPNI    +  R+   S +L+ W DFS  N ++A+ +   +  L+     
Sbjct: 185 DDICFSLNNNSPNIRYSENAVRIEPNSVSLEDWLDFSSTNVEKADKQRNNSLMLKALVDR 244

Query: 246 TIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLR 305
            +++T N+L  Q    + AF+  L++ +    +L       +EEIA  +++I  LE+ + 
Sbjct: 245 ILSQTANDLRKQCDVVDTAFKNGLKDTKDARDKLADHLAKVMEEIASQEKNITALEKAIL 304

Query: 306 TKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDA 365
            +    K++HTRLE RT+RPNVELCRD AQY L  EV ++   +A LK+ LAQAQ  L  
Sbjct: 305 DQEGPAKVAHTRLETRTHRPNVELCRDVAQYRLMKEVQEITHNVARLKETLAQAQAELKG 364

Query: 366 LCKHLARLQADIACKANSMLLD-TKCMDTRRKL 397
           L +    LQ +I  K N++ +D   CM  R+ +
Sbjct: 365 LHRRQLALQEEIQVKENTIYIDEVLCMQMRKSI 397


>gi|13994250 tektin 3 [Homo sapiens]
          Length = 490

 Score =  191 bits (486), Expect = 8e-49
 Identities = 121/386 (31%), Positives = 195/386 (50%), Gaps = 1/386 (0%)

Query: 11  RFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDT 70
           R+   DW+ ++      +   R  S ++R +   L  +   QT   + D    L ER++ 
Sbjct: 93  RYTPDDWYRSNLTNYQESNTSRHNSEKLRVDTSRLIQDKYQQTRKTQADTTQNLGERVND 152

Query: 71  VNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVK 130
           +  WK  +   L ++  E +ALT +K+  E+ L     PL VA ECL  RE R  ID+V 
Sbjct: 153 IGFWKSEIIHELDEMIGETNALTDVKKRLERALMETEAPLQVARECLFHREKRMGIDLVH 212

Query: 131 DPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCL 190
           D VE +L  EV+ I   ++ ++  + +A  QL   +  Q +L  D   K     ID  C 
Sbjct: 213 DEVEAQLLTEVDTILCCQERMKLHLDKAIAQLAANRASQHELEKDLSDKQTAYRIDDKCH 272

Query: 191 SLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAET 250
            L   S  +       RV    +  + W  F+  N  R+++E  A+ +LR+     +  T
Sbjct: 273 HLRNTSDGVGYFRGVERVDATVSVPESWAKFTDDNILRSQSERAASAKLRDDIENLLVVT 332

Query: 251 NNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLS 310
            NE+  Q      +F  R+ E     ++++     TL+EI + +  I  +++ ++ K   
Sbjct: 333 ANEMWNQFNKVNLSFTNRIAETADAKNKIQTHLAKTLQEIFQTEMTIESIKKAIKDKTAF 392

Query: 311 LKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHL 370
           LK++ TRL+ RT RPN+ELCRD AQ  L +EVH+++ TI  L+Q+L  A+D L +L    
Sbjct: 393 LKVAQTRLDERTRRPNIELCRDMAQLRLVNEVHEVDDTIQTLQQRLRDAEDTLQSLVHIK 452

Query: 371 ARLQADIACKANSMLLD-TKCMDTRR 395
           A L+ D+A KANS+ +D  KCM  R+
Sbjct: 453 ATLEYDLAVKANSLYIDQEKCMSMRK 478


>gi|21389613 tektin 4 [Homo sapiens]
          Length = 435

 Score =  189 bits (481), Expect = 3e-48
 Identities = 123/397 (30%), Positives = 201/397 (50%), Gaps = 2/397 (0%)

Query: 1   MATLSVKPSRRFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN 60
           +AT S + S+ + L +W  N Y     A   RD S + R E++ L  ET       + D+
Sbjct: 29  LATASFRTSK-YLLEEWFQNCYARYHQAFADRDQSERQRHESQQLATETQALAQRTQQDS 87

Query: 61  RTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLR 120
              + ER+   + WK  L + +  L AE + L   K+  E+ L A  +P  +  + L  R
Sbjct: 88  TRTVGERLQDTHSWKSELQREMEALAAETNLLLAQKQRLERALDATEVPFSITTDNLQCR 147

Query: 121 ESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKM 180
           E R   ++V+D VE EL KE E+I   ++ L++ + QA  Q+ L +E ++    D   KM
Sbjct: 148 ERREHPNLVRDHVETELLKEAELIRNIQELLKRTIMQAVSQIRLNREHKETCEMDWSDKM 207

Query: 181 ETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELR 240
           E   ID  C   + +S  +      T   + ++T +    F++ N  RA+ E  A+  LR
Sbjct: 208 EAYNIDETCGRHHSQSTEVQAHPYSTTFQESASTPETRAKFTQDNLCRAQRERLASANLR 267

Query: 241 EATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHL 300
                 + +T+ +L  Q  A   AF +R  E+E    +L      TL EI + + ++  L
Sbjct: 268 VLVDCILRDTSEDLRLQCDAVNLAFGRRCEELEDARYKLHHHLHKTLREITDQEHNVAAL 327

Query: 301 EEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQ 360
           ++ ++ K   L ++ TRL  R++RPN+ELCRD AQ+ L  EV +L  ++ AL++KL +A+
Sbjct: 328 KQAIKDKEAPLHVAQTRLYLRSHRPNMELCRDAAQFRLLSEVEELNMSLTALREKLLEAE 387

Query: 361 DALDALCKHLARLQADIACKANSMLLD-TKCMDTRRK 396
            +L  L      L+ DIA   NS+ +D  KCM  R +
Sbjct: 388 QSLRNLEDIHMSLEKDIAAMTNSLFIDRQKCMAHRTR 424


>gi|21389569 tektin 5 [Homo sapiens]
          Length = 485

 Score =  164 bits (414), Expect = 2e-40
 Identities = 114/386 (29%), Positives = 184/386 (47%), Gaps = 1/386 (0%)

Query: 11  RFQLPDWHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDT 70
           R+   DW  ++ L    A+  R  + ++  ++  L  + +  T   +      L +R+  
Sbjct: 88  RYSPHDWDQSNQLQVRGAEASRLWASRLTDDSMRLLQDKDQLTHQMQEGTCRNLGQRLSD 147

Query: 71  VNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVK 130
           +  WK  L   L  L  E   L  +K   E      N PL VA+ECL  RE R  ID+V 
Sbjct: 148 IGFWKSELSYELDRLLTENQNLETVKRRLECAANEVNCPLQVALECLYHREKRIGIDLVH 207

Query: 131 DPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCL 190
           D VE  L +EV++++  ++ +++   +   Q+   ++ Q  L  D   K     ID  C 
Sbjct: 208 DNVEKNLIREVDLLKCCQEQMRKLAQRIDIQMRDNRDAQHVLERDLEDKSSAQCIDEKCF 267

Query: 191 SLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAET 250
           +L   S  IS      ++    +  + W  FS  N   ++     + +LRE         
Sbjct: 268 NLRNTSDCISFFHGMEKIDGTISVPETWAKFSNDNIKHSQNMRANSIQLREEAEHLFETL 327

Query: 251 NNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLS 310
           ++++  Q   T  AF  R+ E+  V ++L+ Q   TL+EI + +  I  LE  +  K   
Sbjct: 328 SDQMWRQFTDTNLAFNARISEVTDVKNKLQTQLAKTLQEIFQAENTIMLLERSIMAKEGP 387

Query: 311 LKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHL 370
           LK++ TRLE RT RPN+ELCRD  Q  L +EV  ++ T+  LK +L + QD L  L    
Sbjct: 388 LKVAQTRLECRTRRPNMELCRDIPQLKLVNEVFTIDDTLQTLKLRLRETQDTLQLLVMTK 447

Query: 371 ARLQADIACKANSMLLD-TKCMDTRR 395
            RL+ ++A KAN++ +D  KCM  R+
Sbjct: 448 CRLEHELAIKANTLCIDKEKCMGMRK 473


>gi|239747088 PREDICTED: MAFF interacting protein [Homo sapiens]
          Length = 445

 Score =  155 bits (393), Expect = 5e-38
 Identities = 106/371 (28%), Positives = 180/371 (48%), Gaps = 12/371 (3%)

Query: 29  QLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAE 88
           +LQ   S Q+  E + L   T       + D+  R+ ER+   N WK  L + +  L AE
Sbjct: 69  ELQGHESQQLAAETQALAQPT-------QQDSTCRVGERLQDTNSWKSELQREVEALAAE 121

Query: 89  IDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATK 148
            D L   K+  E+ L A  +P  +  + +   +  +  ++++D VE EL KE E+I   +
Sbjct: 122 TDLLLAQKQRLERALDAMEVPFSITTDNMQCSQRHQHTNLLRDHVETELLKEAELIRNIQ 181

Query: 149 KALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPT-- 206
           + L++ + QA  Q+ L  E  +    D   K+E   +D+ C   + +S  +      T  
Sbjct: 182 ELLKRAIMQAVSQIXLNXEHMEICEMDWSDKVEAYNLDKTCGRHHSQSTEVQAHPHSTTF 241

Query: 207 --RVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFA 264
             R P  ++T +    F++ N   A+ E   +  L       + +T+ +L  Q  A   A
Sbjct: 242 QERGPRSASTPETRTKFTQDNLCHAQRERLDSANLWVLVDCILRDTSEDLGLQCDAVNLA 301

Query: 265 FRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYR 324
           F +R  E+E    +L+      L EI + + ++  L+E ++ K   L ++ TRL   ++R
Sbjct: 302 FGRRCEELEDARHKLQHHLHKMLREITDQEHNVVALKEAIKDKEEPLHIAQTRLXLLSHR 361

Query: 325 PNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSM 384
           PN++LCRD AQ+ L  EV +L  +I AL++KL QA+ +L  L      L+ D+    NS+
Sbjct: 362 PNMQLCRDAAQFRLVSEVEELYKSITALREKLLQAEQSLRNLKDIHMSLEKDVTAMTNSV 421

Query: 385 LLD-TKCMDTR 394
            +D  KCM  R
Sbjct: 422 FIDRQKCMAHR 432


>gi|239747014 PREDICTED: similar to tektin 4 [Homo sapiens]
          Length = 507

 Score = 82.4 bits (202), Expect = 7e-16
 Identities = 106/470 (22%), Positives = 178/470 (37%), Gaps = 124/470 (26%)

Query: 29  QLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAE 88
           +LQ   S Q+  E + L   T       + D++ R+ ER+  ++ W   L   +  L AE
Sbjct: 39  ELQGHKSQQLAAEIQALAQPT-------QQDSKCRVGERLQDMHSWNSELQGEVEALAAE 91

Query: 89  IDALTQMKESAE--------------------QNLQAKNL----------------PLDV 112
            D L   K+  E                    Q  Q  NL                P   
Sbjct: 92  TDLLLAQKQRLEHALDAMEVPFSIATDNMQCNQRHQHANLVRDHVETELLKAYPPAPSQC 151

Query: 113 AIECLTLRE---SRRDIDVVKDP--VEDELH--------------KEVEVIEATKKALQQ 153
              C + R+   S + +  V +   V++E +              +E E+I   ++ L++
Sbjct: 152 LKNCCSSRKPSASNKGVCEVMETLTVQEEANPGTEGCRTRALAHKEEAELIRNIQELLKR 211

Query: 154 KVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGST 213
            + QA  Q+ L +E  +    D   K+E   +D  C     +S            P  ++
Sbjct: 212 VIVQAVSQIRLNREHMEICEMDWSDKVEAYNLDETCGRHRSQSTE----------PRSAS 261

Query: 214 TLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREME 273
           T +    F++ N  RA+ E   +  L       + +T+ +L  Q  A   AF +R  E+E
Sbjct: 262 TPETRTKFTQDNLCRAQRERLDSANLWVLVDCILRDTSEDLGLQCDAVNLAFGRRCEELE 321

Query: 274 KVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQ 333
               +L+   +  L EI + + ++  L+E ++ K   L ++ TRL   ++RPN+ELCRD 
Sbjct: 322 DARHKLQHHLQKMLREITDQEHNMVALKEAIKDKEAPLHIAQTRLYLLSHRPNMELCRDA 381

Query: 334 AQY-----------------------GLT----------------------------DEV 342
           AQ+                       GLT                             E+
Sbjct: 382 AQFRYRHDTGQVMGRGPPSARDLCPRGLTPPSATSSSQEEAPSDKPQLTPPNTPKLVSEL 441

Query: 343 HQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTK-CM 391
            +L  +I AL +KL QA+ +L  L      L+ D+    NS+ LD + CM
Sbjct: 442 EELYKSITALWEKLLQAEQSLHNLEDIHMSLEKDVTAMTNSLFLDRQNCM 491


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 70/328 (21%), Positives = 144/328 (43%), Gaps = 25/328 (7%)

Query: 46   RNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQA 105
            +NE   +++ +    ++RL      ++R  E  +  ++ L     A TQ  E  ++ L+ 
Sbjct: 1263 KNEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE 1322

Query: 106  KNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKV-------SQA 158
            +N   +     L  + SR D D++++  E+E   + E+  A  KA  +         + A
Sbjct: 1323 ENKAKNALAHAL--QSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDA 1380

Query: 159  FEQLCLLQEVQQQLNSDHRGKMETLE-IDRGCLSLNLRSPNISLKVDPTRVP-DGSTTLQ 216
             ++   L+E +++L    +   E +E ++  C SL      +  +V+   V  + + +L 
Sbjct: 1381 IQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLA 1440

Query: 217  QWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVY 276
               D  + N D+  AE K   E  +A      + +  L  +    + A+ + L ++E V 
Sbjct: 1441 AALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETV- 1499

Query: 277  SELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQY 336
               K + KN  +EIA+L E I    + +       +L  +R +    + +++L  ++A+ 
Sbjct: 1500 ---KRENKNLEQEIADLTEQIAENGKTIH------ELEKSRKQIELEKADIQLALEEAEA 1550

Query: 337  GLTDEVHQLEATIAALKQKLAQAQDALD 364
             L  E    EA I  ++ +L Q +  +D
Sbjct: 1551 ALEHE----EAKILRIQLELTQVKSEID 1574



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 85/393 (21%), Positives = 169/393 (43%), Gaps = 61/393 (15%)

Query: 61   RTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLR 120
            R  L E++ T+ + K  L      + AE + L   +E  +Q ++AK   L+  I+ +T R
Sbjct: 871  RKELEEKLVTLVQEKNDLQ---LQVQAESENLLDAEERCDQLIKAK-FQLEAKIKEVTER 926

Query: 121  -----ESRRDIDVVKDPVEDE---LHKEVEVIEAT-------KKALQQKVSQAFEQLCLL 165
                 E   ++   K  +EDE   L K+++ +E T       K A + KV    E+L  L
Sbjct: 927  AEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGL 986

Query: 166  QEV-------QQQLNSDHRGKMETLEIDRGCL-SLNLRSPNISLKVDPTRVPDGSTTLQQ 217
             E        ++ L   H+  ++ L+ +   + SLN     +  +V+     D  ++L+Q
Sbjct: 987  DETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVE-----DLESSLEQ 1041

Query: 218  WDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYS 277
             +   R + +R + +++   +L + + L +     +L+           +RL++ +  Y 
Sbjct: 1042 -EKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLD-----------ERLKKKDFEYC 1089

Query: 278  EL--KWQEKNTL-----EEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELC 330
            +L  K +++ TL     ++I ELQ  I  LEE++  +  +   + T  +   Y   +E  
Sbjct: 1090 QLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERAT--RAKTEKQRSDYARELEEL 1147

Query: 331  RDQAQY--GLTDEVHQL----EATIAALKQKLAQAQDALDALCKHLARLQADIACKANSM 384
             ++ +   G+T    +L    EA    L++ L +A    +A+   L +  AD   +    
Sbjct: 1148 SERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQ 1207

Query: 385  LLDTKCMDTRRKLTVPAERFVPEVDTFTRTTNS 417
            +        ++KL      F  E+D  + +  S
Sbjct: 1208 I--DNLQRVKQKLEKEKSEFKLEIDDLSSSMES 1238



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 69/340 (20%), Positives = 138/340 (40%), Gaps = 40/340 (11%)

Query: 41   EARVLRNETNNQTIWDEH-DNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESA 99
            E   L++E     +  +H D+   L E+ID + R K+ L+K  ++   EID L+   ES 
Sbjct: 1180 EEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESV 1239

Query: 100  EQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAF 159
             ++        ++   C TL +   +         +E+ + +  +   K  LQ +  +  
Sbjct: 1240 SKS------KANLEKICRTLEDQLSE----ARGKNEEIQRSLSELTTQKSRLQTEAGELS 1289

Query: 160  EQLCLLQEVQQQLN-SDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQW 218
             QL   + +  QL+ S      +T E+ R     N     ++  +  +R  D     +Q+
Sbjct: 1290 RQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSR-HDCDLLREQY 1348

Query: 219  DDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSE 278
                       E E +   EL+ A    +++ N+E+   R   E    +R  E+E+   +
Sbjct: 1349 -----------EEEQEGKAELQRA----LSKANSEVAQWRTKYETDAIQRTEELEEAKKK 1393

Query: 279  LKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGL 338
            L  + +++ E++           E +  K  SL+ +  RL+       V++ R  +    
Sbjct: 1394 LAQRLQDSEEQV-----------EAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAA 1442

Query: 339  TDEVHQ-LEATIAALKQKLAQAQDALDALCKHLARLQADI 377
             D+  +  +  +A  K K  ++Q  L+A  K    L  ++
Sbjct: 1443 LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTEL 1482



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 68/338 (20%), Positives = 139/338 (41%), Gaps = 34/338 (10%)

Query: 64   LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESR 123
            L E I+     +   +K  +D   E++ L++  E A   + +  + L+   E   L+  R
Sbjct: 1119 LEEEIEAERATRAKTEKQRSDYARELEELSERLEEAG-GVTSTQIELNKKREAEFLK-LR 1176

Query: 124  RDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKME-T 182
            RD++      E  L  E  ++ A +K     V++  EQ+  LQ V+Q+L  +   K E  
Sbjct: 1177 RDLE------EATLQHEA-MVAALRKKHADSVAELGEQIDNLQRVKQKLEKE---KSEFK 1226

Query: 183  LEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREA 242
            LEID      +L S   S+      +     TL+     +R   +  +  +   T  +  
Sbjct: 1227 LEID------DLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSR 1280

Query: 243  TALTIAETNNELE------AQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQED 296
                  E + +LE      +Q   ++ AF ++  E+++   E    E      +A   + 
Sbjct: 1281 LQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEE----ENKAKNALAHALQS 1336

Query: 297  IRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGL-----TDEVHQLEATIAA 351
             RH  + LR +    +     L+    + N E+ + + +Y       T+E+ + +  +A 
Sbjct: 1337 SRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQ 1396

Query: 352  LKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTK 389
              Q   +  +A++A C  L + +  +  +   +++D +
Sbjct: 1397 RLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVE 1434



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 66/318 (20%), Positives = 137/318 (43%), Gaps = 56/318 (17%)

Query: 66   ERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRD 125
            ++++++N+ K  L++ + DL++ ++   +++   E+N                 R+   D
Sbjct: 1016 DKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERN----------------KRKLEGD 1059

Query: 126  IDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQ---EVQQQLNSDHRGKMET 182
            + + ++ + D        +E  K+ L +++ +   + C LQ   E +Q L    + K++ 
Sbjct: 1060 LKLAQESILD--------LENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKE 1111

Query: 183  LEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREA 242
            L+          R   +  +++  R     T  Q+  D++R  ++ +E        L EA
Sbjct: 1112 LQ---------ARIEELEEEIEAERATRAKTEKQR-SDYARELEELSE-------RLEEA 1154

Query: 243  TALTIAETNNELEAQRVATEFAFRKRLREM----EKVYSELKWQEKNTLEEIAELQEDIR 298
              +T   T  EL  +R A     R+ L E     E + + L+   K   + +AEL E I 
Sbjct: 1155 GGVT--STQIELNKKREAEFLKLRRDLEEATLQHEAMVAALR---KKHADSVAELGEQID 1209

Query: 299  HLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQ 358
            +L+  ++ KL   K S  +LE      ++E    +++  L      LE  ++  + K  +
Sbjct: 1210 NLQR-VKQKLEKEK-SEFKLEIDDLSSSMESV-SKSKANLEKICRTLEDQLSEARGKNEE 1266

Query: 359  AQDALDALCKHLARLQAD 376
             Q +L  L    +RLQ +
Sbjct: 1267 IQRSLSELTTQKSRLQTE 1284



 Score = 30.4 bits (67), Expect = 3.2
 Identities = 70/349 (20%), Positives = 137/349 (39%), Gaps = 57/349 (16%)

Query: 65   VERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRR 124
            +++++TV R  + L++ + DL  +I      K   E     K + L+ A   L L E+  
Sbjct: 1493 LDQLETVKRENKNLEQEIADLTEQI--AENGKTIHELEKSRKQIELEKADIQLALEEAEA 1550

Query: 125  DIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLE 184
             ++          H+E +++    +  Q K S+   ++    E  +QL  +++  +ET++
Sbjct: 1551 ALE----------HEEAKILRIQLELTQVK-SEIDRKIAEKDEEIEQLKRNYQRTVETMQ 1599

Query: 185  IDRGCLSLNLRSPNISLKVDPTRVPD--------------GSTTLQQWDDFSRFNKD--- 227
                 L   +RS N ++++      D               + TL+         KD   
Sbjct: 1600 ---SALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQL 1656

Query: 228  ------RAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKW 281
                  R + ++K    + E  A  +     EL A    TE A  ++L E E + S  + 
Sbjct: 1657 HLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTERA--RKLAEQELLDSNERV 1714

Query: 282  Q------------EKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVEL 329
            Q            +K    ++ +LQ ++     D R      K + T  +A      ++ 
Sbjct: 1715 QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAIT--DAAMMAEELKK 1772

Query: 330  CRDQAQYGLTDEVHQLEATIAALKQKLAQAQD-ALDALCKHLARLQADI 377
             +D + + L      LE T+  L+ +L +A+  AL    K + +L+  I
Sbjct: 1773 EQDTSAH-LERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRI 1820


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 79/363 (21%), Positives = 163/363 (44%), Gaps = 43/363 (11%)

Query: 24   LSTNAQLQRDASHQIRQEA------RVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEM 77
            LS   Q Q+  S ++++E+      R L+NE  N+  W  H  +T  +E++      KEM
Sbjct: 908  LSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENER-W--HLGKT--IEKLQ-----KEM 957

Query: 78   LDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDEL 137
             D       + ++   Q+ E  E+N + +   +   ++  TL   +  +  +K      +
Sbjct: 958  ADIVEASRTSTLELQNQLDEYKEKN-RRELAEMQRQLKEKTLEAEKSRLTAMK------M 1010

Query: 138  HKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
              E+ ++E   +  Q+   +A  +  LL++  + L  +   K   L+ DR  L   +   
Sbjct: 1011 QDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSH-LKDDRSRLVKQMEDK 1069

Query: 198  NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEM---KAATELREATALTIAETNNEL 254
               L+++     + S  L +    SR   ++   E+   +AA +  E   +++   N +L
Sbjct: 1070 VSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDL 1129

Query: 255  EAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLS 314
            +++ +  E ++R   +E   V  E +         IAEL++ +   E D      +L+LS
Sbjct: 1130 KSRIIHLEGSYRSS-KEGLVVQMEAR---------IAELEDRLESEERDRA----NLQLS 1175

Query: 315  HTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
            + RLE +     +++  D     LTD+  QL   + A+K+++ +A++ +D L     +LQ
Sbjct: 1176 NRRLERKVKELVMQV--DDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQ 1233

Query: 375  ADI 377
             ++
Sbjct: 1234 REL 1236



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 48/181 (26%), Positives = 81/181 (44%), Gaps = 23/181 (12%)

Query: 13   QLPDWHTNSYLLSTNAQLQRDASHQIRQEA---RVLRNETNNQTIWDEHDNRTRLVERID 69
            +L +   NS LLS      R+   Q+R E    R  R +     I  E  N+      I 
Sbjct: 1076 ELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIH 1135

Query: 70   TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQ---NLQAKN---------LPLDVAIECL 117
                ++   +  +  ++A I  L    ES E+   NLQ  N         L + V  E L
Sbjct: 1136 LEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHL 1195

Query: 118  TLRESRRDIDV----VKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLN 173
            +L + +  + +    +K  VE E  +E++ +E++KK LQ+++    EQ+ + + +Q QLN
Sbjct: 1196 SLTDQKDQLSLRLKAMKRQVE-EAEEEIDRLESSKKKLQRELE---EQMDMNEHLQGQLN 1251

Query: 174  S 174
            S
Sbjct: 1252 S 1252



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 65/319 (20%), Positives = 133/319 (41%), Gaps = 50/319 (15%)

Query: 43  RVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQN 102
           +V  N T  Q + +      + +E +  V   +E     + DL    D L++M +  +  
Sbjct: 661 KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQ---DQLSEMHDELDSA 717

Query: 103 LQAKNLPLDVAIE-CLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQ 161
            ++++      IE  L  ++  +D+ + K+  ED L K    + A K AL+++VS   ++
Sbjct: 718 KRSEDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQE 777

Query: 162 LCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDF 221
           +  L+E   Q +++ +   E++E           + N+ +      +   S T +Q    
Sbjct: 778 MDKLKE---QYDAELQALRESVEE---------ATKNVEV------LASRSNTSEQ---- 815

Query: 222 SRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKW 281
                D+A  EM+            + E N +L+ +    E    +R+ ++++   +LK 
Sbjct: 816 -----DQAGTEMRVKL---------LQEENEKLQGRSEELE----RRVAQLQRQIEDLKG 857

Query: 282 QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDE 341
            E    E + + + +IR LEE L      +       EA + R  +E   + AQ  L+  
Sbjct: 858 DEAKAKETLKKYEGEIRQLEEAL------VHARKEEKEAVSARRALENELEAAQGNLSQT 911

Query: 342 VHQLEATIAALKQKLAQAQ 360
             + +     LK++  Q +
Sbjct: 912 TQEQKQLSEKLKEESEQKE 930



 Score = 34.3 bits (77), Expect = 0.22
 Identities = 46/222 (20%), Positives = 94/222 (42%), Gaps = 38/222 (17%)

Query: 21   SYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDK 80
            S+L    ++L +    ++ Q    L  E NN  +  E  +R+R  E+++ +    E+L +
Sbjct: 1053 SHLKDDRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSR--EQMEQLR--NELLQE 1108

Query: 81   CLTDLDAEIDALT--------------------QMKESAEQNLQAKNLPLDVAIEC---- 116
                 D E D ++                      KE     ++A+   L+  +E     
Sbjct: 1109 RAARQDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERD 1168

Query: 117  -----LTLRESRRDIDVVKDPVEDE---LHKEVEVIEATKKALQQKVSQAFEQLCLLQEV 168
                 L+ R   R +  +   V+DE   L  + + +    KA++++V +A E++  L+  
Sbjct: 1169 RANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESS 1228

Query: 169  QQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPD 210
            +++L  +   +M+  E  +G   LN    ++ LK  P++V D
Sbjct: 1229 KKKLQRELEEQMDMNEHLQG--QLNSMKKDLRLKKLPSKVLD 1268


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 83/380 (21%), Positives = 169/380 (44%), Gaps = 44/380 (11%)

Query: 26  TNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
           +N  L+RD    +RQE + L+     +  + E   +   +E+   + + +   D  +TD 
Sbjct: 76  SNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKE--LEKYQGLQQQEAKPDGLVTDS 133

Query: 86  DAEIDALTQMKESAE-QNLQAKNL-------PLDVAIECLTLRESRRDIDVVKDPVE--- 134
            AE+ +L Q  E A+ +N   K +          +A E   ++    +   +++  E   
Sbjct: 134 SAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKV 193

Query: 135 ----DELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCL 190
               +EL+KE  VI+  K  L Q+     E + +L++   Q+ +     M+ + ++R   
Sbjct: 194 TRLTEELNKEATVIQDLKTELLQR--PGIEDVAVLKKELVQVQT----LMDNMTLERERE 247

Query: 191 SLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAET 250
           S  L+     L+   ++      T+      S+   + A+   + A  ++E   L  +  
Sbjct: 248 SEKLKDECKKLQ---SQYASSEATI------SQLRSELAKGPQEVAVYVQELQKLK-SSV 297

Query: 251 NNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLS 310
           N   +  +  TE   +K     E+ Y++L  +EK+  E +++        ++DL  + L 
Sbjct: 298 NELTQKNQTLTENLLKK-----EQDYTKL--EEKHNEESVSKKNIQATLHQKDLDCQQLQ 350

Query: 311 LKLSHTRLEARTYRPNVELC-RDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKH 369
            +LS +  E   +R +VEL  + +A   L +E+ ++E     LK +  Q Q   +   +H
Sbjct: 351 SRLSAS--ETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQH 408

Query: 370 LARLQADIACKANSMLLDTK 389
             +LQ++I  + +S LL+T+
Sbjct: 409 GLQLQSEIN-QLHSKLLETE 427



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 77/361 (21%), Positives = 154/361 (42%), Gaps = 36/361 (9%)

Query: 31  QRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVER--IDTVNRWKEMLDKCLTDLDAE 88
           +R       Q+   L  E N +    + D +T L++R  I+ V     +L K L  +   
Sbjct: 182 ERSLREAAEQKVTRLTEELNKEATVIQ-DLKTELLQRPGIEDV----AVLKKELVQVQTL 236

Query: 89  IDALTQMKESAEQNL--QAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELH-KEVEVIE 145
           +D +T  +E   + L  + K L    A    T+ + R ++   K P E  ++ +E++ ++
Sbjct: 237 MDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSEL--AKGPQEVAVYVQELQKLK 294

Query: 146 ATKKALQQKVSQAFEQLCLLQEVQQQLNSDH----------RGKMETLEIDRGCLSLNLR 195
           ++   L QK     E L   ++   +L   H          +  +   ++D   L   L 
Sbjct: 295 SSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLS 354

Query: 196 SPNISL-KVDPTRVPDGSTTLQQWDDFS----RFNKDRAE-AEMKAATELREATALTIAE 249
           +   SL ++       G  T +  ++ S    ++   +AE  +++   E +E   L +  
Sbjct: 355 ASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQS 414

Query: 250 TNNELEAQRVATEFAFRK---RLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRT 306
             N+L ++ + TE    +   RL+E  ++ SE K  +K   +++A+LQ  +  LEE L+ 
Sbjct: 415 EINQLHSKLLETERQLGEAHGRLKEQRQLSSE-KLMDKE--QQVADLQLKLSRLEEQLKE 471

Query: 307 KLL-SLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDA 365
           K+  S +L H   + +      +  +      L +  + LE  +  +  K  + Q+ L+A
Sbjct: 472 KVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQN-LEA 530

Query: 366 L 366
           L
Sbjct: 531 L 531



 Score = 42.7 bits (99), Expect = 6e-04
 Identities = 66/344 (19%), Positives = 153/344 (44%), Gaps = 40/344 (11%)

Query: 66   ERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRD 125
            E+  ++ +  E L+  +  L+A+   +   KE A Q+LQ +             R+   D
Sbjct: 716  EKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQ-------------RQLNTD 762

Query: 126  IDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFE----QLCLLQEVQQQLNSDHRGKME 181
            +++    +  +L  E E++ +T+  LQ+K S+A E    +L   +E +Q L  D     +
Sbjct: 763  LELRATELSKQLEMEKEIVSSTRLDLQKK-SEALESIKQKLTKQEEEKQILKQDFETLSQ 821

Query: 182  TLEIDRGCLSLNLRSPNISL---KVDPTRVPDGSTTLQQWDDFSRFNKD--RAEAEMKAA 236
              +I    L+  +++    L   K++   +    +T++  D  S+ +     +++E +  
Sbjct: 822  ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVK--DKLSKVSDSLKNSKSEFEKE 879

Query: 237  TELREATALTIAETNNELEAQ-------RVATEFAFRKRLREMEKVYSELKWQEKNTLEE 289
             +  +A  L + +T  EL+ Q        +  +   +K L + ++   +LK +  +  E+
Sbjct: 880  NQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQ 939

Query: 290  IAELQEDIRHLEED---LRTKLLSLKLSHTRLEARTYRPNVELC-----RDQAQYGLTDE 341
            + + Q  ++  E++   L+  +  LK S  + + +      EL      + + +  L  +
Sbjct: 940  LIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQ 999

Query: 342  VHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSML 385
            + Q    +AA K+K++  Q+  +   +   +LQ+D   + + +L
Sbjct: 1000 LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELL 1043



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 76/380 (20%), Positives = 153/380 (40%), Gaps = 70/380 (18%)

Query: 46  RNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQA 105
           +N+T  + +  +  + T+L E+ +  +  K+ +   L   D +   L     ++E +L  
Sbjct: 303 KNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHR 362

Query: 106 KNLPLDVAIECLT-LRESRRDIDVVKDPVEDE---LHKEVEVIEATKKALQQKVSQAFEQ 161
            ++ L    E    L+E   +++     ++ E   L ++ E  E     LQ +++Q   +
Sbjct: 363 IHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422

Query: 162 LCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPD-------GSTT 214
           L    E ++QL   H    E  ++    L ++       L++  +R+ +        ST 
Sbjct: 423 LL---ETERQLGEAHGRLKEQRQLSSEKL-MDKEQQVADLQLKLSRLEEQLKEKVTNSTE 478

Query: 215 LQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEA---------QRVATEFAF 265
           LQ          D+ + + +    L+++T   + E  N+LE          Q++    A 
Sbjct: 479 LQH-------QLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEAL 531

Query: 266 RKRLRE--------MEKVYSELKWQEKNT--LEEIAE----LQEDIRHLEEDLRTKLLSL 311
            ++ +E         E +Y++++  E  T  L ++ E    LQE +  L E L+ +  S 
Sbjct: 532 LQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH 591

Query: 312 KLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLA 371
           K                    QAQ  L D+V + +A + A + ++   + +++ L   L 
Sbjct: 592 K--------------------QAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLN 631

Query: 372 R-----LQADIACKANSMLL 386
                  Q DI  KA + LL
Sbjct: 632 ESKEKVSQLDIQIKAKTELL 651


>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
          Length = 1060

 Score = 55.5 bits (132), Expect = 9e-08
 Identities = 63/304 (20%), Positives = 137/304 (45%), Gaps = 46/304 (15%)

Query: 120 RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGK 179
           ++ +R+++   + V  +  KE++ +E  K AL  K+  +  ++  L+E  QQ  +   G 
Sbjct: 455 KKLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGA 514

Query: 180 MET-----------LEIDRGCLSLNLRSP--------------NISLKVDPTRV------ 208
            E+           LE    CL L+  SP                S + + T+V      
Sbjct: 515 EESPQELGRQHCSILETQDPCLKLDETSPRGEEYQDKLAAEEGTSSDEEERTKVLLKEGS 574

Query: 209 ----PDGSTTLQQWDDFSRFNKD--RAEAEMKA-ATELREATALTIAETNNELEAQRVAT 261
               P GS   ++     R  +D    +A+++A  +++++A     +    +L+A +  +
Sbjct: 575 DPQPPLGSLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLS 634

Query: 262 EFAFRKRLREMEKVYSE---LKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHT-R 317
           +    K  RE+++   +   +K Q + + +    + E  RH E     + L  + SH+ +
Sbjct: 635 DLEREKLQRELQETTQQNHAMKAQLEASHQRALRMLEKARHQELKATEERLKKESSHSLQ 694

Query: 318 LEARTYRPNVELCRDQAQYGLTDEVHQLEA----TIAALKQKLAQAQDALDALCKHLARL 373
           ++ +T+R  ++   ++A+  L +E  +++A     + +L+Q+L++ Q A     K L  L
Sbjct: 695 IQHQTHRLELQALEEKARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDLEAL 754

Query: 374 QADI 377
           QA++
Sbjct: 755 QAEL 758



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 90/395 (22%), Positives = 161/395 (40%), Gaps = 70/395 (17%)

Query: 24  LSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLT 83
           L +  +LQ+  + +   E+   R ET  + +  E ++     ER+ T++R  EML+    
Sbjct: 104 LESALELQKRLTEEALAESASCRLETKERELRVEAEH----AERVLTLSR--EMLE-LKA 156

Query: 84  DLDAEIDALTQMKESAEQNL-----QAKNLP------LDVAIECLTLRESRRDIDVVKDP 132
           D +  +  LT  + + +  L     + K+ P       +V +E   LR   + +      
Sbjct: 157 DYERRLQHLTSHEATPQGRLPQESPETKSEPGQGPEMQEVLLEVQRLRVENQQLSKDYAR 216

Query: 133 VEDELHKEVE-VIEATKKALQQKVSQAF---------------EQLCLLQEVQQQLNSD- 175
             +EL    E   EA ++A+QQ VSQA                 Q   LQ   ++L  D 
Sbjct: 217 KAEELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDL 276

Query: 176 -HRG-KMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEM 233
            HRG K+  L+     L   ++  ++ LK       +   T ++  +     KDR   + 
Sbjct: 277 EHRGRKISDLKKYAQKLKERIQDLDVQLKEARQENSELKGTAKKLGEKLAVAKDRMMLQE 336

Query: 234 KAATELREATALTIAETN------NELEA--------QRVATEFAFRKRLREME---KVY 276
              T+  +A    +   N      N+LEA        Q    E    K   +M+   +  
Sbjct: 337 CRGTQQTDAMKTELVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEAS 396

Query: 277 SELKWQEKNTLEEIAEL----QEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRD 332
           +E ++ ++   E++ ++    +E+ +HL++ L  +L  L   HT +E ++ R +VE  R 
Sbjct: 397 AETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHT-VEIKSVRSSVEAERK 455

Query: 333 QAQYGL-----------TDEVHQLEATIAALKQKL 356
           + Q  +             E+ QLE   AAL  KL
Sbjct: 456 KLQREVEAQLEEVRKKSEKEIKQLEEEKAALNVKL 490



 Score = 36.6 bits (83), Expect = 0.045
 Identities = 68/316 (21%), Positives = 125/316 (39%), Gaps = 58/316 (18%)

Query: 17  WHTNSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKE 76
           W      L  N Q+Q  A   ++ + R L  +        EH  R     +I  + ++ +
Sbjct: 247 WQEKESDLRKNFQVQESA---LQAQVRKLEGDL-------EHRGR-----KISDLKKYAQ 291

Query: 77  MLDKCLTDLDAEIDALTQMKESAEQNLQAKNL--PLDVAIECLTLRESR--RDIDVVKDP 132
            L + + DLD ++    Q  E++E    AK L   L VA + + L+E R  +  D +K  
Sbjct: 292 KLKERIQDLDVQLKEARQ--ENSELKGTAKKLGEKLAVAKDRMMLQECRGTQQTDAMKTE 349

Query: 133 V--EDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCL 190
           +  E+++ +E   +EA     QQ  S   E  C+      Q   +   + E ++      
Sbjct: 350 LVSENKVLREENDLEAGNLHPQQDQSCLKECPCMKGGTDMQTKKEASAETEYMK------ 403

Query: 191 SLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMK-AATELREATALTIAE 249
                                    QQ+++  R  K + E E K    +L +     + +
Sbjct: 404 -------------------------QQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKK 438

Query: 250 TNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLL 309
              E+++ R + E   +K  RE+E    E++   K + +EI +L+E+   L   L+  LL
Sbjct: 439 HTVEIKSVRSSVEAERKKLQREVEAQLEEVR---KKSEKEIKQLEEEKAALNVKLQNSLL 495

Query: 310 SLKLSHTRLEARTYRP 325
            +      ++    RP
Sbjct: 496 EVLRLEEFIQQNKTRP 511


>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
           sapiens]
          Length = 600

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 54/243 (22%), Positives = 106/243 (43%), Gaps = 23/243 (9%)

Query: 136 ELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLR 195
           +L  +++ +E T   LQ+++S A +++C LQE QQQL   +      L  +R   S+ + 
Sbjct: 216 DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNE-----LIRERSEKSVEIT 270

Query: 196 SPNISLKVD---PTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNN 252
             +  ++++    TR          W       K R E E +   ++   T + IA    
Sbjct: 271 KQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLL 330

Query: 253 ELEA-QRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSL 311
           E +  ++  T  A R++L E++ +  ++  + +N    + +  E I   E      + S+
Sbjct: 331 EKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSM 390

Query: 312 KLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLE----ATIAALKQKLAQAQDALDALC 367
           K    RL+            ++A+ G  +  H+L+      I AL+ +L+Q  +   +L 
Sbjct: 391 KQMEERLQH----------SERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 440

Query: 368 KHL 370
           K L
Sbjct: 441 KEL 443



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 61/330 (18%), Positives = 133/330 (40%), Gaps = 21/330 (6%)

Query: 57  EHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
           EH+  T ++++ + V      L   + DL  +ID L +     ++ L A           
Sbjct: 189 EHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSA------ATDRI 242

Query: 117 LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLC-LLQEVQQQLNSD 175
            +L+E ++ +    + + +   K VE+ +   K   +   Q  + L  +  +V +QL  +
Sbjct: 243 CSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEE 302

Query: 176 HRGKME---TLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTL-QQWDDFSRFNKDRAEA 231
            + ++E    LE+  G +   +      L+ D     D    L QQ ++    N      
Sbjct: 303 KKVRLELEKELELQIG-MKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHK 361

Query: 232 EMKAATELREAT-ALT--------IAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQ 282
              A + L++   A+T        +  +  ++E +   +E A +       K+  EL  +
Sbjct: 362 AQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGR 421

Query: 283 EKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEV 342
                 ++++L E    LE++L+++    +     L+      ++     Q   GL  E+
Sbjct: 422 IGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKEL 481

Query: 343 HQLEATIAALKQKLAQAQDALDALCKHLAR 372
            +L+   A L++   + + AL  +  HL++
Sbjct: 482 RELQDEKAELQKICEEQEQALQEMGLHLSQ 511


>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
           sapiens]
          Length = 600

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 54/243 (22%), Positives = 106/243 (43%), Gaps = 23/243 (9%)

Query: 136 ELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLR 195
           +L  +++ +E T   LQ+++S A +++C LQE QQQL   +      L  +R   S+ + 
Sbjct: 216 DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNE-----LIRERSEKSVEIT 270

Query: 196 SPNISLKVD---PTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNN 252
             +  ++++    TR          W       K R E E +   ++   T + IA    
Sbjct: 271 KQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLL 330

Query: 253 ELEA-QRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSL 311
           E +  ++  T  A R++L E++ +  ++  + +N    + +  E I   E      + S+
Sbjct: 331 EKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSM 390

Query: 312 KLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLE----ATIAALKQKLAQAQDALDALC 367
           K    RL+            ++A+ G  +  H+L+      I AL+ +L+Q  +   +L 
Sbjct: 391 KQMEERLQH----------SERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 440

Query: 368 KHL 370
           K L
Sbjct: 441 KEL 443



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 61/330 (18%), Positives = 133/330 (40%), Gaps = 21/330 (6%)

Query: 57  EHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
           EH+  T ++++ + V      L   + DL  +ID L +     ++ L A           
Sbjct: 189 EHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSA------ATDRI 242

Query: 117 LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLC-LLQEVQQQLNSD 175
            +L+E ++ +    + + +   K VE+ +   K   +   Q  + L  +  +V +QL  +
Sbjct: 243 CSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEE 302

Query: 176 HRGKME---TLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTL-QQWDDFSRFNKDRAEA 231
            + ++E    LE+  G +   +      L+ D     D    L QQ ++    N      
Sbjct: 303 KKVRLELEKELELQIG-MKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHK 361

Query: 232 EMKAATELREAT-ALT--------IAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQ 282
              A + L++   A+T        +  +  ++E +   +E A +       K+  EL  +
Sbjct: 362 AQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGR 421

Query: 283 EKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEV 342
                 ++++L E    LE++L+++    +     L+      ++     Q   GL  E+
Sbjct: 422 IGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKEL 481

Query: 343 HQLEATIAALKQKLAQAQDALDALCKHLAR 372
            +L+   A L++   + + AL  +  HL++
Sbjct: 482 RELQDEKAELQKICEEQEQALQEMGLHLSQ 511


>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
           sapiens]
          Length = 708

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 54/243 (22%), Positives = 106/243 (43%), Gaps = 23/243 (9%)

Query: 136 ELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLR 195
           +L  +++ +E T   LQ+++S A +++C LQE QQQL   +      L  +R   S+ + 
Sbjct: 324 DLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNE-----LIRERSEKSVEIT 378

Query: 196 SPNISLKVD---PTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNN 252
             +  ++++    TR          W       K R E E +   ++   T + IA    
Sbjct: 379 KQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLL 438

Query: 253 ELEA-QRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSL 311
           E +  ++  T  A R++L E++ +  ++  + +N    + +  E I   E      + S+
Sbjct: 439 EKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSM 498

Query: 312 KLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLE----ATIAALKQKLAQAQDALDALC 367
           K    RL+            ++A+ G  +  H+L+      I AL+ +L+Q  +   +L 
Sbjct: 499 KQMEERLQH----------SERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLE 548

Query: 368 KHL 370
           K L
Sbjct: 549 KEL 551



 Score = 42.4 bits (98), Expect = 8e-04
 Identities = 61/330 (18%), Positives = 133/330 (40%), Gaps = 21/330 (6%)

Query: 57  EHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
           EH+  T ++++ + V      L   + DL  +ID L +     ++ L A           
Sbjct: 297 EHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSA------ATDRI 350

Query: 117 LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLC-LLQEVQQQLNSD 175
            +L+E ++ +    + + +   K VE+ +   K   +   Q  + L  +  +V +QL  +
Sbjct: 351 CSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEE 410

Query: 176 HRGKME---TLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTL-QQWDDFSRFNKDRAEA 231
            + ++E    LE+  G +   +      L+ D     D    L QQ ++    N      
Sbjct: 411 KKVRLELEKELELQIG-MKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHK 469

Query: 232 EMKAATELREAT-ALT--------IAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQ 282
              A + L++   A+T        +  +  ++E +   +E A +       K+  EL  +
Sbjct: 470 AQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGR 529

Query: 283 EKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEV 342
                 ++++L E    LE++L+++    +     L+      ++     Q   GL  E+
Sbjct: 530 IGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKEL 589

Query: 343 HQLEATIAALKQKLAQAQDALDALCKHLAR 372
            +L+   A L++   + + AL  +  HL++
Sbjct: 590 RELQDEKAELQKICEEQEQALQEMGLHLSQ 619


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 76/328 (23%), Positives = 149/328 (45%), Gaps = 59/328 (17%)

Query: 62   TRLVERIDTVNRWKEMLDKCLTDLDAEIDAL-TQMKESAEQNLQAKNLPLDVAIECLTLR 120
            + L E +++    +   +K   DL  E++AL T+++++           LD       LR
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDT-----------LDSTAAQQELR 1162

Query: 121  ESR-RDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGK 179
              R ++++++K  +E+E     +  EA  + ++QK SQA E+L    E  +++ ++    
Sbjct: 1163 SKREQEVNILKKTLEEE----AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKA 1218

Query: 180  METLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATEL 239
             +TLE +RG L+  ++                   L Q    S   + + EA+++   EL
Sbjct: 1219 KQTLENERGELANEVK------------------VLLQGKGDSEHKRKKVEAQLQ---EL 1257

Query: 240  REATALTIAETNNELEAQRVATEFAFR--KRLREMEKVYSELKWQEKNTLEEI------- 290
            +        + N   E +RV TE A +  K   E++ V   L   +  + +         
Sbjct: 1258 Q-------VKFN---EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307

Query: 291  AELQEDIRHLEEDLRTKL-LSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATI 349
            ++LQ+    L+E+ R KL LS KL     E  ++R  +E   ++A++ L  ++  L A +
Sbjct: 1308 SQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEE-EEEAKHNLEKQIATLHAQV 1366

Query: 350  AALKQKLAQAQDALDALCKHLARLQADI 377
            A +K+K+  +   L+   +   +LQ D+
Sbjct: 1367 ADMKKKMEDSVGCLETAEEVKRKLQKDL 1394



 Score = 52.4 bits (124), Expect = 8e-07
 Identities = 61/275 (22%), Positives = 117/275 (42%), Gaps = 32/275 (11%)

Query: 92   LTQMKESAEQNLQAKNLPLDVAIE-----CLTLRESRRDIDVVKDPVEDELHKEVEVIEA 146
            LT+M E+ +  L A+ L L   ++     C    E R  +   K  +E+  H     +E 
Sbjct: 868  LTEM-ETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEE 926

Query: 147  TKKALQQKVSQAFEQLCLLQEVQQQLNSDH--RGKMETLEIDRGCLSLNLRSPNISLKVD 204
             ++  Q   ++  +    +QE+++QL  +   R K++  ++        L    I L+  
Sbjct: 927  EEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQ 986

Query: 205  PTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFA 264
              ++      L+  D  + F  +  E E K+ +         +A+  N+ EA     E  
Sbjct: 987  NCKLAKEKKLLE--DRIAEFTTNLTEEEEKSKS---------LAKLKNKHEAMITDLEER 1035

Query: 265  FR---KRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEAR 321
             R   K+ +E+EK   +L+    +  ++IAELQ  I  L+  L  K   L+ +  R+E  
Sbjct: 1036 LRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEE 1095

Query: 322  TYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKL 356
              + N+ L           ++ +LE+ I+ L++ L
Sbjct: 1096 AAQKNMAL----------KKIRELESQISELQEDL 1120



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 81/394 (20%), Positives = 154/394 (39%), Gaps = 57/394 (14%)

Query: 58   HDNRTRLVERID-TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
            H+ +    ++++ T  R ++ LD  L DLD +       ++SA  NL+ K    D     
Sbjct: 1401 HEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ-------RQSA-CNLEKKQKKFD----- 1447

Query: 117  LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDH 176
              L    + I        D    E    E    +L + + +A EQ   L+    +LN   
Sbjct: 1448 -QLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELE----RLNKQF 1502

Query: 177  RGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKD---RAEAEM 233
            R +ME L   +  +  ++     S +    +V +  T L++ +D  +  +D   R E  +
Sbjct: 1503 RTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNL 1562

Query: 234  KA---------------ATELREATALTIAETNNELEAQRVATEFAF--RKRLR-EMEKV 275
            +A               + E ++     + E   ELE +R     A   RK+L  +++ +
Sbjct: 1563 QAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDL 1622

Query: 276  YSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQ 335
             + +    KN  E I +L++ ++   +D   +L   + S   + A+      +L   +A 
Sbjct: 1623 EAHIDSANKNRDEAIKQLRK-LQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEA- 1680

Query: 336  YGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCMDTRR 395
                 E+ QL+  +AA ++   QAQ   D L   +          ANS       ++ +R
Sbjct: 1681 -----EMIQLQEELAAAERAKRQAQQERDELADEI----------ANSSGKGALALEEKR 1725

Query: 396  KLTVPAERFVPEVDTFTRTTNSTLSPLKSCQLEL 429
            +L     +   E++     T      LK   L++
Sbjct: 1726 RLEARIAQLEEELEEEQGNTELINDRLKKANLQI 1759



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 74/364 (20%), Positives = 150/364 (41%), Gaps = 37/364 (10%)

Query: 27   NAQLQRDASHQIRQEARVLRN-ETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
            ++Q   + + Q+ Q  RV  N E   QT+ +E   R  L   +  + + K   +     +
Sbjct: 1194 HSQAVEELAEQLEQTKRVKANLEKAKQTLENE---RGELANEVKVLLQGKGDSEHKRKKV 1250

Query: 86   DAEIDALTQMK----ESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEV 141
            +A++  L Q+K    E     L  K   L V ++ +T   S+       D    +L K+ 
Sbjct: 1251 EAQLQEL-QVKFNEGERVRTELADKVTKLQVELDNVTGLLSQ------SDSKSSKLTKDF 1303

Query: 142  EVIEA----TKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
              +E+    T++ LQ++  Q       L++V+ + NS  R ++E  E  +  L   + + 
Sbjct: 1304 SALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNS-FREQLEEEEEAKHNLEKQIATL 1362

Query: 198  NISLKVDPTRVPDGSTTLQQWDDFSR-FNKDRAEAEMKAATELREATALTIAETNNELEA 256
            +  +     ++ D    L+  ++  R   KD      +   ++     L   +T  + E 
Sbjct: 1363 HAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQEL 1422

Query: 257  QRVATEFAFRKR----LREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLK 312
              +  +   +++    L + +K + +L  +EK    + AE ++       +  TK LS  
Sbjct: 1423 DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS-- 1480

Query: 313  LSHTRLEARTYRPNVELCRDQAQYGLTD----------EVHQLEATIAALKQKLAQAQDA 362
            L+    EA   +  +E    Q +  + D           VH+LE +  AL+Q++ + +  
Sbjct: 1481 LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540

Query: 363  LDAL 366
            L+ L
Sbjct: 1541 LEEL 1544



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 87/388 (22%), Positives = 143/388 (36%), Gaps = 72/388 (18%)

Query: 64   LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKN---LPLDVAIECLTLR 120
            L+   D V +    L+K    L+ +++ +    E  E  LQA     L L+V ++ +   
Sbjct: 1509 LMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM--- 1565

Query: 121  ESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKM 180
                     K   E +L    E  E  KK L ++V +   +L    E +++  S      
Sbjct: 1566 ---------KAQFERDLQGRDEQSEEKKKQLVRQVREMEAEL----EDERKQRSMAVAAR 1612

Query: 181  ETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELR 240
            + LE+D   L  ++ S N +   D           Q  D     +  RA  E   A    
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNR--DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKE 1670

Query: 241  EATALTIAETNN-ELEAQRVATEFAFRKRLREMEKVYSE---------LKWQEKNTLE-E 289
                L   E    +L+ +  A E A R+  +E +++  E         L  +EK  LE  
Sbjct: 1671 NEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEAR 1730

Query: 290  IAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYG------------ 337
            IA+L+E++   EE   T+L++ +L    L+      ++ L R  AQ              
Sbjct: 1731 IAQLEEELE--EEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLERQNK 1788

Query: 338  ----------------LTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKA 381
                                +  LEA IA L+++L        A CK + R +     K 
Sbjct: 1789 ELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRTEK----KL 1844

Query: 382  NSMLLDTKCMDTRRKLTVPAERFVPEVD 409
              +LL     D RR     AE++  + D
Sbjct: 1845 KDVLLQVD--DERRN----AEQYKDQAD 1866


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 71/364 (19%), Positives = 150/364 (41%), Gaps = 31/364 (8%)

Query: 28  AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTR--LVERIDTVNRWK---EMLDKCL 82
           ++L R A    +Q  R L     ++ + +E + R     ++  +++ +WK   + L++ L
Sbjct: 445 SELTRHAEDATKQAERYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERAL 504

Query: 83  TDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECL-TLRESRRDIDVVKDPVEDELHKEV 141
                 +D LT       +        L  A++ +  LR+   D+   +   E+ELH + 
Sbjct: 505 EKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKELNDVLTKRALQEEELHSKE 564

Query: 142 EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
           E +   K            Q  L  EV+  L++ HR + E  +  +    + +   ++  
Sbjct: 565 EKLRDIKS----------HQADLELEVKNSLDTIHRLESELKKQSKIQSQMKVEKAHLEE 614

Query: 202 KV---DPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATE-------LREATALTIAETN 251
           ++     ++  D +  L+  +     +  RA+   K A E       L++ + LT    +
Sbjct: 615 EIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLKDLSDLTAQAKS 674

Query: 252 NELEAQRVATEFAFRKRL--REMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLL 309
            + E   + T+    + +  RE++ + S L+  +    + I EL +  +  + +    + 
Sbjct: 675 RDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAENHIR 734

Query: 310 SLKLSHTRLE--ARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALC 367
           +LK      +  A+ +R  +E  + Q    LT+E+ Q E     LK K    +D L+   
Sbjct: 735 TLKAESLEEKNMAKIHRGQLEKLKSQCDR-LTEELTQNENENKKLKLKYQCLKDQLEERE 793

Query: 368 KHLA 371
           KH++
Sbjct: 794 KHIS 797



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 79/357 (22%), Positives = 141/357 (39%), Gaps = 60/357 (16%)

Query: 60  NRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAE-QNLQAKNLPLDVAIECLT 118
           N + +   ++ V R  E  DK    L ++++ LT+  E+ E Q LQ  +   ++     T
Sbjct: 373 NFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQMLDRLKEIQNHFDT 432

Query: 119 LRESRRDIDVVKDPVEDELHKEVEVIEATKKA------------LQQKVSQAFEQLCL-L 165
               R+  D+       EL +  E  +ATK+A            L+++  +  E L L  
Sbjct: 433 CEAERKHADLQIS----ELTRHAE--DATKQAERYLSELQQSEALKEEAEKRREDLKLKA 486

Query: 166 QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFN 225
           QE  +Q    H+     LE     +       N  LK            LQQ ++  +  
Sbjct: 487 QESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKEL 546

Query: 226 KD----RAEAEMKAATELREATALTIAETNNELEAQR-VATEFAFRKRLREMEKVYSELK 280
            D    RA  E +  ++  +   +   + + ELE +  + T       L++  K+ S++K
Sbjct: 547 NDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQSQMK 606

Query: 281 WQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTD 340
            ++ +  EEIAEL++     +   + KLL ++                           +
Sbjct: 607 VEKAHLEEEIAELKKS----QAQDKAKLLEMQ---------------------------E 635

Query: 341 EVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCMDTRRKL 397
            +  L A  A L  KLA+ + A  A+ K L    +D+  +A S   +T  + T+ KL
Sbjct: 636 SIKDLSAIRADLANKLAEEERAKKAVLKDL----SDLTAQAKSRDEETATIITQLKL 688



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 74/348 (21%), Positives = 139/348 (39%), Gaps = 29/348 (8%)

Query: 39  RQEARVLRNETNNQTIWDEHDNRTRLVERI-DTVNRWKEMLDKCLTDLDAEIDALT-QMK 96
           +QE    R E   Q +  E      LVER  D +      L + L   +A+ D     +K
Sbjct: 212 KQEVVSDRVERRLQELEREMRTERELVERRQDQLGLMSLQLQEALKKQEAKADEHEGAIK 271

Query: 97  ESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKV 155
               Q    KN L  ++ +    L +S    + +   VE EL  ++   E  +K LQ +V
Sbjct: 272 NKLRQTETEKNQLEQELELSRRLLNQSEGSRETLLHQVE-ELRTQLTKAEGDRKGLQHQV 330

Query: 156 SQAFEQLCLLQEVQQQLNSDHRG---KMETLEIDRGCLSLNLRSPNISLKVDPT------ 206
           SQ  +Q    Q+ Q +     RG   + + LE     L + L    ++ +++        
Sbjct: 331 SQISKQQSNYQDEQGEDWRFRRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMER 390

Query: 207 RVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFR 266
           +  + +    Q ++ +R  ++  + +++    L+E     I    +  EA+R   +    
Sbjct: 391 KDKEKAHLASQVENLTRELENGEKQQLQMLDRLKE-----IQNHFDTCEAERKHADLQIS 445

Query: 267 KRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTK----LLSLKLSHTRLEART 322
           +  R  E    + + +  + L++   L+E+     EDL+ K    +   KL H +LE   
Sbjct: 446 ELTRHAEDATKQAE-RYLSELQQSEALKEEAEKRREDLKLKAQESIRQWKLKHKKLERAL 504

Query: 323 YRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHL 370
            +      + +    LT + +Q+      LK +L  A   ++ L K L
Sbjct: 505 EK------QSETVDELTGKNNQILKEKDELKTQLYAALQQIENLRKEL 546


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 68/362 (18%), Positives = 147/362 (40%), Gaps = 64/362 (17%)

Query: 34  ASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALT 93
           A++  + +ARV   ET      +      +L+         K+ L   +TDL + I  L+
Sbjct: 426 AANNTQLQARVEMLET------ERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLS 479

Query: 94  QMKESAEQNLQAKNLPLDVAIECLT---------LRESRRDIDVVKDPVEDELHKEVEVI 144
           Q KE  EQ  QA    L   +  LT         +++  +++  +K   +++  +  + +
Sbjct: 480 QAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTL 539

Query: 145 EATKKA----------LQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNL 194
           +  ++A          L   + Q  +QL  + E Q+    DH  ++ T   +R     +L
Sbjct: 540 QQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEER---EASL 596

Query: 195 RSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNEL 254
           R  + +LK            L+  +       +  + +++ A E R++   ++ +     
Sbjct: 597 RERDAALK-----------QLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQ----- 640

Query: 255 EAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLS 314
            AQR   E +  +++ E++      + ++     ++AEL+  +R                
Sbjct: 641 -AQREKAELS--RKVEELQACVETARQEQHEAQAQVAELELQLR---------------- 681

Query: 315 HTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
            +  +  T +  V   +DQ Q  L      L+ T  +L+++  +A DAL+   + ++ L+
Sbjct: 682 -SEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740

Query: 375 AD 376
           A+
Sbjct: 741 AE 742



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 79/367 (21%), Positives = 145/367 (39%), Gaps = 62/367 (16%)

Query: 25   STNAQLQRDASHQIRQEARVLRNETNNQTIWDEH--DNRTRLVERIDTVNR----WKEML 78
            ++N+    + S  +R+E + LR E   Q +  E+     T   ER + + +    W+E  
Sbjct: 1277 ASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKF 1336

Query: 79   ---DKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIE-CLTLRESRRDIDVVKDPVE 134
               ++ L+ L  E    T  +    + L AK+L   +  E     +  R +++  K    
Sbjct: 1337 FQKEQALSTLQLEH---TSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAG 1393

Query: 135  D----------------ELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRG 178
                              L ++V   E T + L+ + +   EQL +L++    L  ++RG
Sbjct: 1394 GLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRG 1453

Query: 179  KMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATE 238
              E   + R  L + L         +   V                   RA+AE + A  
Sbjct: 1454 LGERANLGRQFLEVELDQAREKYVQELAAV-------------------RADAETRLAEV 1494

Query: 239  LREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIR 298
             REA +     T  ELE      E A  K L E ++       +E+  L    E Q ++ 
Sbjct: 1495 QREAQS-----TARELEVMTAKYEGAKVKVLEERQRFQ-----EERQKLTAQVE-QLEVF 1543

Query: 299  HLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLT-DEVHQLEATIAALKQKLA 357
              E+  + + LS KL+ +   ++  +  ++    QAQ G +  E  +L+A +  L+ +L+
Sbjct: 1544 QREQTKQVEELSKKLADSDQASKVQQQKLKAV--QAQGGESQQEAQRLQAQLNELQAQLS 1601

Query: 358  QAQDALD 364
            Q + A +
Sbjct: 1602 QKEQAAE 1608



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 68/322 (21%), Positives = 135/322 (41%), Gaps = 21/322 (6%)

Query: 87   AEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEA 146
            A+ D   +    AE  ++ +N   +  +E  TL+E+       K+  + EL K +  +EA
Sbjct: 1016 AQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK-LRGLEA 1074

Query: 147  TK----KALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLK 202
             +    + L+Q V Q  EQL   +E +    S  + +        G     LR+    L+
Sbjct: 1075 AQIKELEELRQTVKQLKEQLAK-KEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLE 1133

Query: 203  VDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNEL-EAQRVAT 261
                +  + + +L++  +  R ++   ++ ++      E  A  +  + + L  AQR   
Sbjct: 1134 QQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELA 1193

Query: 262  EFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEAR 321
              AFR ++++  K   E K Q     +E       I  LEE++   +L+ ++     E++
Sbjct: 1194 --AFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEV--SILNRQVLEKEGESK 1249

Query: 322  TYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKA 381
              +  + +   +    L + +  L+A  A+   + A+   AL    + L R +A+    A
Sbjct: 1250 ELK-RLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL-REEAEKQRVA 1307

Query: 382  NSMLLDTKCMDTRRKLTVPAER 403
            +  L        R++LT  AER
Sbjct: 1308 SENL--------RQELTSQAER 1321


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 87/365 (23%), Positives = 153/365 (41%), Gaps = 75/365 (20%)

Query: 33   DASHQIRQEARVLRNETN--NQTIWDEHDNRTRLVERIDTVN-RWKEMLDKCLTDLDAEI 89
            D  HQ RQ A  L  +    +Q + +E     R  E  D      +E   K L+   A  
Sbjct: 1435 DLDHQ-RQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALE 1493

Query: 90   DALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKK 149
            +AL   +E   QN Q              LR    D+   KD V   +H+    +E +K+
Sbjct: 1494 EALEAKEEFERQNKQ--------------LRADMEDLMSSKDDVGKNVHE----LEKSKR 1535

Query: 150  ALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVP 209
            AL+Q+V +   Q   L+E++ +L +    K+         L +N+++     + D     
Sbjct: 1536 ALEQQVEEMRTQ---LEELEDELQATEDAKLR--------LEVNMQAMKAQFERD----- 1579

Query: 210  DGSTTLQQWDDFSRFNKDRAEAEMKAATEL-------REATALTIAETN------NELEA 256
                 LQ  D+    N+++    +K   EL       R+  AL +A          +LEA
Sbjct: 1580 -----LQTRDE---QNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEA 1631

Query: 257  QRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHT 316
            Q  A   A  + ++++ K+ +++K  ++  LEE    +++I    ++   KL SL+    
Sbjct: 1632 QIEAANKARDEVIKQLRKLQAQMKDYQRE-LEEARASRDEIFAQSKESEKKLKSLEAEIL 1690

Query: 317  RLE-----ARTYRPNVELCRDQ----------AQYGLTDEVHQLEATIAALKQKLAQAQD 361
            +L+     +   R + E  RD+           +  L DE  +LEA IA L+++L + Q 
Sbjct: 1691 QLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQS 1750

Query: 362  ALDAL 366
             ++ L
Sbjct: 1751 NMELL 1755



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 80/383 (20%), Positives = 159/383 (41%), Gaps = 40/383 (10%)

Query: 41   EARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAE 100
            EA+      N Q   D  D    L+   D V +    L+K    L+ +++ +    E  E
Sbjct: 1497 EAKEEFERQNKQLRADMED----LMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELE 1552

Query: 101  QNLQAKN---LPLDVAIECLTLRESRRDIDVVKDPVEDE---LHKEVEVIEAT----KKA 150
              LQA     L L+V ++ +   +  RD+    +  E++   L K+V  +EA     +K 
Sbjct: 1553 DELQATEDAKLRLEVNMQAMKA-QFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQ 1611

Query: 151  LQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPD 210
                V+   +    L++++ Q+ + ++ + E ++         LR     +K       D
Sbjct: 1612 RALAVASKKKMEIDLKDLEAQIEAANKARDEVIK--------QLRKLQAQMK-------D 1656

Query: 211  GSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLR 270
                L++    +R ++D   A+ K + +  ++    I +   EL +   A   A ++R  
Sbjct: 1657 YQRELEE----ARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDE 1712

Query: 271  EMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRP---NV 327
              +++ +    +    L+E   L+  I  LEE+L  +  +++L + R    T +    N 
Sbjct: 1713 LADEITNSASGKSA-LLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA 1771

Query: 328  ELCRDQAQYGLTDEV-HQLEATIAALKQKLAQAQDALDALCK-HLARLQADIACKANSML 385
            EL  +++    +D    QLE     LK KL + + A+ +  K  ++ L+A I      + 
Sbjct: 1772 ELAAERSAAQKSDNARQQLERQNKELKAKLQELEGAVKSKFKATISALEAKIGQLEEQLE 1831

Query: 386  LDTKCMDTRRKLTVPAERFVPEV 408
             + K      KL    E+ + E+
Sbjct: 1832 QEAKERAAANKLVRRTEKKLKEI 1854



 Score = 39.7 bits (91), Expect = 0.005
 Identities = 61/277 (22%), Positives = 113/277 (40%), Gaps = 40/277 (14%)

Query: 92   LTQMKESAEQNLQAKNL---PLDVAIECLT-LRESRRDIDVVKDPVEDELHKEVEVIEAT 147
            L +M+   +Q L+ KN+    L    E      E R  +   K  +E+ LH     +E  
Sbjct: 875  LEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEE 934

Query: 148  KKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTR 207
            ++  Q   ++  +    +Q++++QL+ +  G  + L++++      ++     +      
Sbjct: 935  EERNQILQNEKKKMQAHIQDLEEQLDEEE-GARQKLQLEKVTAEAKIKKMEEEI------ 987

Query: 208  VPDGSTTLQQWDDFSRFNKDR-------AEAEMKAATELREATALTIAETNNELEAQRVA 260
                   L   D  S+F K++       AE   + A E  E  A  +A+  N+ E     
Sbjct: 988  -------LLLEDQNSKFIKEKKLMEDRIAECSSQLAEE--EEKAKNLAKIRNKQEVMISD 1038

Query: 261  TEFAFRKRLR---EMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTR 317
             E   +K  +   E+EK   +L  +  +  ++IAELQ  I  L+  L  K   L+ +  R
Sbjct: 1039 LEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALAR 1098

Query: 318  LEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQ 354
             +  T   N  L            V +L+A IA L++
Sbjct: 1099 GDDETLHKNNAL----------KVVRELQAQIAELQE 1125



 Score = 37.7 bits (86), Expect = 0.020
 Identities = 75/332 (22%), Positives = 137/332 (41%), Gaps = 47/332 (14%)

Query: 80   KCLTDLDAEIDALTQMKESAEQNL-QAKNLPLDVAIECLTLRESRRD-IDVVKDPVEDEL 137
            K + +L A+I  L +  ES + +  +A+    D++ E   L+    D +D      E   
Sbjct: 1111 KVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRT 1170

Query: 138  HKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
             +E EV E  KKAL+++      Q+   Q+++Q+  +      E LE  +     NL   
Sbjct: 1171 KREQEVAEL-KKALEEETKNHEAQI---QDMRQRHATALEELSEQLEQAKR-FKANLEKN 1225

Query: 198  NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKA-------ATELREATALTIAET 250
               L+ D   +      LQQ    S   + + +A+++           LR   A   ++ 
Sbjct: 1226 KQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKL 1285

Query: 251  NNEL--------EAQRVATEFA-----FRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
             NEL        EA++   +FA        +L++ +++  E   Q+ N    I +L+E+ 
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEK 1345

Query: 298  RHLEE----------DLRTKLLSL--KLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQL 345
              L+E          +L  ++L+L  +L+ T+ +       +E         L +   +L
Sbjct: 1346 NSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE--------SLEEAKKKL 1397

Query: 346  EATIAALKQKLAQAQDALDALCKHLARLQADI 377
                 AL Q+L +   A D L K   RLQ ++
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQEL 1429



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 82/409 (20%), Positives = 152/409 (37%), Gaps = 52/409 (12%)

Query: 41   EARVLRNETNNQTIWDEHDNRTR----LVERIDTVNRWKEMLDKCLTDLDAEIDALTQ-- 94
            E+RV   E  NQ + +E          L E++D     ++ L       +A+I  + +  
Sbjct: 928  ESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEI 987

Query: 95   --MKESAEQNLQAKNLPLDVAIECLT-----------LRESRRDIDVVKDPVEDELHKEV 141
              +++   + ++ K L  D   EC +           L + R   +V+   +E+ L KE 
Sbjct: 988  LLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEE 1047

Query: 142  EV---IEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPN 198
            +    +E  K+ L  + +   +Q+  LQ    +L      K E L+             N
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107

Query: 199  ISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMK---------------------AAT 237
             +LKV    +      LQ+  +  + ++++AE + +                     A  
Sbjct: 1108 NALKV-VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQ 1166

Query: 238  ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
            ELR      +AE    LE +    E   +   +       EL  Q +      A L+++ 
Sbjct: 1167 ELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNK 1226

Query: 298  RHLEEDLRTKLLSLK-LSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKL 356
            + LE D +     +K L   + E+   R  ++  + Q  +    E  +L   +A    KL
Sbjct: 1227 QGLETDNKELACEVKVLQQVKAESEHKRKKLD-AQVQELHAKVSEGDRLRVELAEKASKL 1285

Query: 357  AQAQDALDALCKHLARLQ---ADIACKANSMLLDTKCM---DTRRKLTV 399
                D +  L +   +     A  A    S L DT+ +   +TR+KL +
Sbjct: 1286 QNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL 1334


>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
            sapiens]
          Length = 1935

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 75/349 (21%), Positives = 156/349 (44%), Gaps = 33/349 (9%)

Query: 57   EHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
            E DN     ER D + + K  L+  + +++  ++     +E     L AK   L+   EC
Sbjct: 894  EQDNLADAEERCDQLIKNKIQLEAKVKEMNERLED----EEEMNAELTAKKRKLED--EC 947

Query: 117  LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDH 176
              L+    D+++    VE E H      E   K L ++++   E +  L + ++ L   H
Sbjct: 948  SELKRDIDDLELTLAKVEKEKH----ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1003

Query: 177  RGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAA 236
            +  ++ L+ +   ++  L    + L+    +V D   +L+Q +   R + +RA+ +++  
Sbjct: 1004 QQALDDLQAEEDKVN-TLTKAKVKLE---QQVDDLEGSLEQ-EKKVRMDLERAKRKLEGD 1058

Query: 237  TELREATALTIAETNNELEAQRVATEF---AFRKRLREMEKVYSELKWQEKNTLEEIAEL 293
             +L + + + +     +L+ +    +F   A   R+ + + + S+L+ + K     I EL
Sbjct: 1059 LKLTQESIMDLENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEEL 1118

Query: 294  QEDI------RHLEEDLRTKLL-SLKLSHTRLEARTYRPNVEL---CRDQAQY-----GL 338
            +E++      R   E LR+ L   L+    RLE      +V++    + +A++      L
Sbjct: 1119 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1178

Query: 339  TDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLD 387
             +   Q EAT AAL++K A +   L     +L R++  +  + +   L+
Sbjct: 1179 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLE 1227



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 75/393 (19%), Positives = 165/393 (41%), Gaps = 42/393 (10%)

Query: 41   EARVLRNETNNQTIWDEH-DNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESA 99
            E   L++E     +  +H D+   L E+ID + R K+ L+K  ++   E+D +T    + 
Sbjct: 1179 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT---SNM 1235

Query: 100  EQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAF 159
            EQ ++AK    ++   C TL              ED++++     E T++++    SQ  
Sbjct: 1236 EQIIKAK---ANLEKMCRTL--------------EDQMNEHRSKAEETQRSVNDLTSQRA 1278

Query: 160  EQLCLLQEVQQQLNSDHRGKMETL--EIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQ 217
            +      E+ +QL+     + E L  ++ RG L+   +  ++  +++          L  
Sbjct: 1279 KLQTENGELSRQLD-----EKEALISQLTRGKLTYTQQLEDLKRQLE--EEVKAKNALAH 1331

Query: 218  WDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYS 277
                +R + D    + +  TE +      +++ N+E+   R   E    +R  E+E+   
Sbjct: 1332 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEA-- 1389

Query: 278  ELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYG 337
                 +K   + + E +E +    E +  K  SL+ +  RL+       V++ R  A   
Sbjct: 1390 -----KKKLAQRLQEAEEAV----EAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1440

Query: 338  LTDEVHQ-LEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCMDTRRK 396
              D+  +  +  +A  KQK  ++Q  L++  K    L  ++    N+     + ++T ++
Sbjct: 1441 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKR 1500

Query: 397  LTVPAERFVPEVDTFTRTTNSTLSPLKSCQLEL 429
                 +  + ++     ++  T+  L+  + +L
Sbjct: 1501 ENKNLQEEISDLTEQLGSSGKTIHELEKVRKQL 1533



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 63/291 (21%), Positives = 129/291 (44%), Gaps = 34/291 (11%)

Query: 90   DALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDEL---HKEVEVIEA 146
            +  T++KE+ E++ +A+   L+  +  ++L + + D+ +     +D L    +  + +  
Sbjct: 854  EEFTRLKEALEKS-EARRKELEEKM--VSLLQEKNDLQLQVQAEQDNLADAEERCDQLIK 910

Query: 147  TKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMET----LEIDRGCLSLNLRSPNISLK 202
             K  L+ KV +  E+L   +E+  +L +  R K+E     L+ D   L L L        
Sbjct: 911  NKIQLEAKVKEMNERLEDEEEMNAELTAKKR-KLEDECSELKRDIDDLELTLAKVEKEKH 969

Query: 203  VDPTRVPDGSTTLQQWDDF----SRFNKDRAEAEMKAATELR----EATALTIAETNNEL 254
                +V + +  +   D+     ++  K   EA  +A  +L+    +   LT A+   E 
Sbjct: 970  ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKVNTLTKAKVKLEQ 1029

Query: 255  EAQRVATEFAFRKRLR-EMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKL 313
            +   +       K++R ++E+   +L+   K T E I +L+ D + L+E L+ K   L  
Sbjct: 1030 QVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQLDERLKKKDFELNA 1089

Query: 314  SHTRLEARTYRPNVELCRDQAQYG--LTDEVHQLEATIAALKQKLAQAQDA 362
             + R+E            D+   G  L  ++ +L+A I  L+++L   + A
Sbjct: 1090 LNARIE------------DEQALGSQLQKKLKELQARIEELEEELEAERTA 1128


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)

Query: 11   RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
            R QL +      LL    Q L+ +A+   RQ ++V   E    ++  + +  ++L  RI+
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2248

Query: 70   TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
              NR   + DK  T    + +A  +MK+ AE+   A  L +  A E   LR+ +  D+  
Sbjct: 2249 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2303

Query: 129  VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
             +   E  L ++++ + EAT+     + LQQ+   A EQ   LQE    + QQL  + +G
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363

Query: 179  KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
               TLE +R   L ++  +  + L+V            +  +D  RF K   E  E    
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2419

Query: 237  TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
            TEL     +T+ +T   LE QR  ++        A  +  RE EK+  E K         
Sbjct: 2420 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476

Query: 282  ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
               Q++  L+E   LQ+     ++ L  +   ++    +LE       A+  +   E  R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536

Query: 332  DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
             Q Q  +  E  +L A++   +++  +A++ +    + L +L+
Sbjct: 2537 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
            AQL+R    +    A+ LR E   +        R R  E    + RW+   ++ L  L  
Sbjct: 1590 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1646

Query: 88   EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
            + + + Q K  A+   + +    +        RE+RR     +  V      E EL K+ 
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 142  EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
            ++ E T    QQ+++   E + L  E +Q        + E   + R   +   +   +  
Sbjct: 1699 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755

Query: 202  KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
            ++   R      +   +   ++    S  +K R EAE     EL E  A   A       
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815

Query: 256  AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
             +++A E A R+R  E E+V +E          LK + +  L+E     E +R L ED  
Sbjct: 1816 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874

Query: 304  LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
             + + L  + +  + +       +    D   + Q GL ++      Q+E  I ALK   
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934

Query: 357  AQAQDALDALCKHLARLQAD 376
             +A      L   L R++++
Sbjct: 1935 EKAAAGKAELELELGRIRSN 1954



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
            AQ + D   ++ Q  +   +E   Q   + D    R ++ E I  +    E       +L
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944

Query: 86   DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
            + E   L +++ +AE  L++K    L+ A +     E  R     ++ V+  L  E E  
Sbjct: 1945 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001

Query: 145  EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
               K AL++  ++    E+   L     QE  +QL        + L+ +    +  ++  
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061

Query: 198  NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
               L+    +       L+   + +R   + AE     AE +AA   R+       + + 
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121

Query: 253  ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
            E +AQ R   + A  K  +E E+  +     E+  L +     AE+++  +  E+ LR K
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181

Query: 308  LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
                  +    E  T R  +E   D  +  L +E+ +L+A      ++ +Q ++ L ++ 
Sbjct: 2182 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 367  --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
               + L++L+A I  +  +++L  K  +T+R L   AE+
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2272



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)

Query: 120  RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
            ++S  D + +++ +  EL +E E ++   K LQ K    Q  +Q  LLQE Q    S   
Sbjct: 2439 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497

Query: 178  GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
             K   L+ +R                    +      L+Q          +   E +   
Sbjct: 2498 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2538

Query: 238  ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
            +  E     +  +  E   ++   E   R++  E++++  + + QE+   EE   L+E +
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598

Query: 298  RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
            + LEE  R  L  S +++ +++ A    PN
Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2628


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)

Query: 11   RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
            R QL +      LL    Q L+ +A+   RQ ++V   E    ++  + +  ++L  RI+
Sbjct: 2196 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2252

Query: 70   TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
              NR   + DK  T    + +A  +MK+ AE+   A  L +  A E   LR+ +  D+  
Sbjct: 2253 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2307

Query: 129  VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
             +   E  L ++++ + EAT+     + LQQ+   A EQ   LQE    + QQL  + +G
Sbjct: 2308 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2367

Query: 179  KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
               TLE +R   L ++  +  + L+V            +  +D  RF K   E  E    
Sbjct: 2368 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2423

Query: 237  TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
            TEL     +T+ +T   LE QR  ++        A  +  RE EK+  E K         
Sbjct: 2424 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2480

Query: 282  ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
               Q++  L+E   LQ+     ++ L  +   ++    +LE       A+  +   E  R
Sbjct: 2481 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2540

Query: 332  DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
             Q Q  +  E  +L A++   +++  +A++ +    + L +L+
Sbjct: 2541 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2581



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
            AQL+R    +    A+ LR E   +        R R  E    + RW+   ++ L  L  
Sbjct: 1594 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1650

Query: 88   EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
            + + + Q K  A+   + +    +        RE+RR     +  V      E EL K+ 
Sbjct: 1651 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1702

Query: 142  EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
            ++ E T    QQ+++   E + L  E +Q        + E   + R   +   +   +  
Sbjct: 1703 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1759

Query: 202  KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
            ++   R      +   +   ++    S  +K R EAE     EL E  A   A       
Sbjct: 1760 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1819

Query: 256  AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
             +++A E A R+R  E E+V +E          LK + +  L+E     E +R L ED  
Sbjct: 1820 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878

Query: 304  LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
             + + L  + +  + +       +    D   + Q GL ++      Q+E  I ALK   
Sbjct: 1879 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1938

Query: 357  AQAQDALDALCKHLARLQAD 376
             +A      L   L R++++
Sbjct: 1939 EKAAAGKAELELELGRIRSN 1958



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
            AQ + D   ++ Q  +   +E   Q   + D    R ++ E I  +    E       +L
Sbjct: 1889 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1948

Query: 86   DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
            + E   L +++ +AE  L++K    L+ A +     E  R     ++ V+  L  E E  
Sbjct: 1949 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2005

Query: 145  EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
               K AL++  ++    E+   L     QE  +QL        + L+ +    +  ++  
Sbjct: 2006 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2065

Query: 198  NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
               L+    +       L+   + +R   + AE     AE +AA   R+       + + 
Sbjct: 2066 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2125

Query: 253  ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
            E +AQ R   + A  K  +E E+  +     E+  L +     AE+++  +  E+ LR K
Sbjct: 2126 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2185

Query: 308  LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
                  +    E  T R  +E   D  +  L +E+ +L+A      ++ +Q ++ L ++ 
Sbjct: 2186 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2238

Query: 367  --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
               + L++L+A I  +  +++L  K  +T+R L   AE+
Sbjct: 2239 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2276



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)

Query: 120  RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
            ++S  D + +++ +  EL +E E ++   K LQ K    Q  +Q  LLQE Q    S   
Sbjct: 2443 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2501

Query: 178  GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
             K   L+ +R                    +      L+Q          +   E +   
Sbjct: 2502 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2542

Query: 238  ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
            +  E     +  +  E   ++   E   R++  E++++  + + QE+   EE   L+E +
Sbjct: 2543 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2602

Query: 298  RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
            + LEE  R  L  S +++ +++ A    PN
Sbjct: 2603 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2632


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)

Query: 11   RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
            R QL +      LL    Q L+ +A+   RQ ++V   E    ++  + +  ++L  RI+
Sbjct: 2192 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2248

Query: 70   TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
              NR   + DK  T    + +A  +MK+ AE+   A  L +  A E   LR+ +  D+  
Sbjct: 2249 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2303

Query: 129  VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
             +   E  L ++++ + EAT+     + LQQ+   A EQ   LQE    + QQL  + +G
Sbjct: 2304 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2363

Query: 179  KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
               TLE +R   L ++  +  + L+V            +  +D  RF K   E  E    
Sbjct: 2364 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2419

Query: 237  TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
            TEL     +T+ +T   LE QR  ++        A  +  RE EK+  E K         
Sbjct: 2420 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2476

Query: 282  ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
               Q++  L+E   LQ+     ++ L  +   ++    +LE       A+  +   E  R
Sbjct: 2477 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2536

Query: 332  DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
             Q Q  +  E  +L A++   +++  +A++ +    + L +L+
Sbjct: 2537 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2577



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
            AQL+R    +    A+ LR E   +        R R  E    + RW+   ++ L  L  
Sbjct: 1590 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1646

Query: 88   EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
            + + + Q K  A+   + +    +        RE+RR     +  V      E EL K+ 
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1698

Query: 142  EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
            ++ E T    QQ+++   E + L  E +Q        + E   + R   +   +   +  
Sbjct: 1699 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1755

Query: 202  KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
            ++   R      +   +   ++    S  +K R EAE     EL E  A   A       
Sbjct: 1756 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1815

Query: 256  AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
             +++A E A R+R  E E+V +E          LK + +  L+E     E +R L ED  
Sbjct: 1816 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874

Query: 304  LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
             + + L  + +  + +       +    D   + Q GL ++      Q+E  I ALK   
Sbjct: 1875 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1934

Query: 357  AQAQDALDALCKHLARLQAD 376
             +A      L   L R++++
Sbjct: 1935 EKAAAGKAELELELGRIRSN 1954



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
            AQ + D   ++ Q  +   +E   Q   + D    R ++ E I  +    E       +L
Sbjct: 1885 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1944

Query: 86   DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
            + E   L +++ +AE  L++K    L+ A +     E  R     ++ V+  L  E E  
Sbjct: 1945 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2001

Query: 145  EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
               K AL++  ++    E+   L     QE  +QL        + L+ +    +  ++  
Sbjct: 2002 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2061

Query: 198  NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
               L+    +       L+   + +R   + AE     AE +AA   R+       + + 
Sbjct: 2062 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2121

Query: 253  ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
            E +AQ R   + A  K  +E E+  +     E+  L +     AE+++  +  E+ LR K
Sbjct: 2122 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2181

Query: 308  LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
                  +    E  T R  +E   D  +  L +E+ +L+A      ++ +Q ++ L ++ 
Sbjct: 2182 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2234

Query: 367  --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
               + L++L+A I  +  +++L  K  +T+R L   AE+
Sbjct: 2235 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2272



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)

Query: 120  RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
            ++S  D + +++ +  EL +E E ++   K LQ K    Q  +Q  LLQE Q    S   
Sbjct: 2439 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497

Query: 178  GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
             K   L+ +R                    +      L+Q          +   E +   
Sbjct: 2498 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2538

Query: 238  ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
            +  E     +  +  E   ++   E   R++  E++++  + + QE+   EE   L+E +
Sbjct: 2539 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2598

Query: 298  RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
            + LEE  R  L  S +++ +++ A    PN
Sbjct: 2599 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2628


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)

Query: 11   RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
            R QL +      LL    Q L+ +A+   RQ ++V   E    ++  + +  ++L  RI+
Sbjct: 2160 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2216

Query: 70   TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
              NR   + DK  T    + +A  +MK+ AE+   A  L +  A E   LR+ +  D+  
Sbjct: 2217 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2271

Query: 129  VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
             +   E  L ++++ + EAT+     + LQQ+   A EQ   LQE    + QQL  + +G
Sbjct: 2272 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2331

Query: 179  KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
               TLE +R   L ++  +  + L+V            +  +D  RF K   E  E    
Sbjct: 2332 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2387

Query: 237  TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
            TEL     +T+ +T   LE QR  ++        A  +  RE EK+  E K         
Sbjct: 2388 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2444

Query: 282  ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
               Q++  L+E   LQ+     ++ L  +   ++    +LE       A+  +   E  R
Sbjct: 2445 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2504

Query: 332  DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
             Q Q  +  E  +L A++   +++  +A++ +    + L +L+
Sbjct: 2505 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2545



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
            AQL+R    +    A+ LR E   +        R R  E    + RW+   ++ L  L  
Sbjct: 1558 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1614

Query: 88   EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
            + + + Q K  A+   + +    +        RE+RR     +  V      E EL K+ 
Sbjct: 1615 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1666

Query: 142  EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
            ++ E T    QQ+++   E + L  E +Q        + E   + R   +   +   +  
Sbjct: 1667 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1723

Query: 202  KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
            ++   R      +   +   ++    S  +K R EAE     EL E  A   A       
Sbjct: 1724 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1783

Query: 256  AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
             +++A E A R+R  E E+V +E          LK + +  L+E     E +R L ED  
Sbjct: 1784 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842

Query: 304  LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
             + + L  + +  + +       +    D   + Q GL ++      Q+E  I ALK   
Sbjct: 1843 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1902

Query: 357  AQAQDALDALCKHLARLQAD 376
             +A      L   L R++++
Sbjct: 1903 EKAAAGKAELELELGRIRSN 1922



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
            AQ + D   ++ Q  +   +E   Q   + D    R ++ E I  +    E       +L
Sbjct: 1853 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1912

Query: 86   DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
            + E   L +++ +AE  L++K    L+ A +     E  R     ++ V+  L  E E  
Sbjct: 1913 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1969

Query: 145  EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
               K AL++  ++    E+   L     QE  +QL        + L+ +    +  ++  
Sbjct: 1970 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2029

Query: 198  NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
               L+    +       L+   + +R   + AE     AE +AA   R+       + + 
Sbjct: 2030 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2089

Query: 253  ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
            E +AQ R   + A  K  +E E+  +     E+  L +     AE+++  +  E+ LR K
Sbjct: 2090 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2149

Query: 308  LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
                  +    E  T R  +E   D  +  L +E+ +L+A      ++ +Q ++ L ++ 
Sbjct: 2150 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2202

Query: 367  --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
               + L++L+A I  +  +++L  K  +T+R L   AE+
Sbjct: 2203 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2240



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)

Query: 120  RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
            ++S  D + +++ +  EL +E E ++   K LQ K    Q  +Q  LLQE Q    S   
Sbjct: 2407 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2465

Query: 178  GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
             K   L+ +R                    +      L+Q          +   E +   
Sbjct: 2466 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2506

Query: 238  ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
            +  E     +  +  E   ++   E   R++  E++++  + + QE+   EE   L+E +
Sbjct: 2507 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2566

Query: 298  RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
            + LEE  R  L  S +++ +++ A    PN
Sbjct: 2567 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2596


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)

Query: 11   RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
            R QL +      LL    Q L+ +A+   RQ ++V   E    ++  + +  ++L  RI+
Sbjct: 2329 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2385

Query: 70   TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
              NR   + DK  T    + +A  +MK+ AE+   A  L +  A E   LR+ +  D+  
Sbjct: 2386 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2440

Query: 129  VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
             +   E  L ++++ + EAT+     + LQQ+   A EQ   LQE    + QQL  + +G
Sbjct: 2441 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2500

Query: 179  KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
               TLE +R   L ++  +  + L+V            +  +D  RF K   E  E    
Sbjct: 2501 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2556

Query: 237  TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
            TEL     +T+ +T   LE QR  ++        A  +  RE EK+  E K         
Sbjct: 2557 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2613

Query: 282  ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
               Q++  L+E   LQ+     ++ L  +   ++    +LE       A+  +   E  R
Sbjct: 2614 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2673

Query: 332  DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
             Q Q  +  E  +L A++   +++  +A++ +    + L +L+
Sbjct: 2674 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
            AQL+R    +    A+ LR E   +        R R  E    + RW+   ++ L  L  
Sbjct: 1727 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1783

Query: 88   EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
            + + + Q K  A+   + +    +        RE+RR     +  V      E EL K+ 
Sbjct: 1784 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1835

Query: 142  EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
            ++ E T    QQ+++   E + L  E +Q        + E   + R   +   +   +  
Sbjct: 1836 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1892

Query: 202  KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
            ++   R      +   +   ++    S  +K R EAE     EL E  A   A       
Sbjct: 1893 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1952

Query: 256  AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
             +++A E A R+R  E E+V +E          LK + +  L+E     E +R L ED  
Sbjct: 1953 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011

Query: 304  LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
             + + L  + +  + +       +    D   + Q GL ++      Q+E  I ALK   
Sbjct: 2012 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 2071

Query: 357  AQAQDALDALCKHLARLQAD 376
             +A      L   L R++++
Sbjct: 2072 EKAAAGKAELELELGRIRSN 2091



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
            AQ + D   ++ Q  +   +E   Q   + D    R ++ E I  +    E       +L
Sbjct: 2022 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 2081

Query: 86   DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
            + E   L +++ +AE  L++K    L+ A +     E  R     ++ V+  L  E E  
Sbjct: 2082 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2138

Query: 145  EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
               K AL++  ++    E+   L     QE  +QL        + L+ +    +  ++  
Sbjct: 2139 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2198

Query: 198  NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
               L+    +       L+   + +R   + AE     AE +AA   R+       + + 
Sbjct: 2199 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2258

Query: 253  ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
            E +AQ R   + A  K  +E E+  +     E+  L +     AE+++  +  E+ LR K
Sbjct: 2259 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2318

Query: 308  LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
                  +    E  T R  +E   D  +  L +E+ +L+A      ++ +Q ++ L ++ 
Sbjct: 2319 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371

Query: 367  --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
               + L++L+A I  +  +++L  K  +T+R L   AE+
Sbjct: 2372 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2409



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)

Query: 120  RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
            ++S  D + +++ +  EL +E E ++   K LQ K    Q  +Q  LLQE Q    S   
Sbjct: 2576 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634

Query: 178  GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
             K   L+ +R                    +      L+Q          +   E +   
Sbjct: 2635 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2675

Query: 238  ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
            +  E     +  +  E   ++   E   R++  E++++  + + QE+   EE   L+E +
Sbjct: 2676 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2735

Query: 298  RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
            + LEE  R  L  S +++ +++ A    PN
Sbjct: 2736 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2765


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)

Query: 11   RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
            R QL +      LL    Q L+ +A+   RQ ++V   E    ++  + +  ++L  RI+
Sbjct: 2170 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2226

Query: 70   TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
              NR   + DK  T    + +A  +MK+ AE+   A  L +  A E   LR+ +  D+  
Sbjct: 2227 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2281

Query: 129  VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
             +   E  L ++++ + EAT+     + LQQ+   A EQ   LQE    + QQL  + +G
Sbjct: 2282 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2341

Query: 179  KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
               TLE +R   L ++  +  + L+V            +  +D  RF K   E  E    
Sbjct: 2342 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2397

Query: 237  TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
            TEL     +T+ +T   LE QR  ++        A  +  RE EK+  E K         
Sbjct: 2398 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2454

Query: 282  ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
               Q++  L+E   LQ+     ++ L  +   ++    +LE       A+  +   E  R
Sbjct: 2455 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2514

Query: 332  DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
             Q Q  +  E  +L A++   +++  +A++ +    + L +L+
Sbjct: 2515 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
            AQL+R    +    A+ LR E   +        R R  E    + RW+   ++ L  L  
Sbjct: 1568 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1624

Query: 88   EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
            + + + Q K  A+   + +    +        RE+RR     +  V      E EL K+ 
Sbjct: 1625 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1676

Query: 142  EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
            ++ E T    QQ+++   E + L  E +Q        + E   + R   +   +   +  
Sbjct: 1677 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1733

Query: 202  KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
            ++   R      +   +   ++    S  +K R EAE     EL E  A   A       
Sbjct: 1734 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1793

Query: 256  AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
             +++A E A R+R  E E+V +E          LK + +  L+E     E +R L ED  
Sbjct: 1794 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852

Query: 304  LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
             + + L  + +  + +       +    D   + Q GL ++      Q+E  I ALK   
Sbjct: 1853 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1912

Query: 357  AQAQDALDALCKHLARLQAD 376
             +A      L   L R++++
Sbjct: 1913 EKAAAGKAELELELGRIRSN 1932



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
            AQ + D   ++ Q  +   +E   Q   + D    R ++ E I  +    E       +L
Sbjct: 1863 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1922

Query: 86   DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
            + E   L +++ +AE  L++K    L+ A +     E  R     ++ V+  L  E E  
Sbjct: 1923 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1979

Query: 145  EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
               K AL++  ++    E+   L     QE  +QL        + L+ +    +  ++  
Sbjct: 1980 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2039

Query: 198  NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
               L+    +       L+   + +R   + AE     AE +AA   R+       + + 
Sbjct: 2040 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2099

Query: 253  ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
            E +AQ R   + A  K  +E E+  +     E+  L +     AE+++  +  E+ LR K
Sbjct: 2100 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2159

Query: 308  LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
                  +    E  T R  +E   D  +  L +E+ +L+A      ++ +Q ++ L ++ 
Sbjct: 2160 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212

Query: 367  --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
               + L++L+A I  +  +++L  K  +T+R L   AE+
Sbjct: 2213 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2250



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)

Query: 120  RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
            ++S  D + +++ +  EL +E E ++   K LQ K    Q  +Q  LLQE Q    S   
Sbjct: 2417 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2475

Query: 178  GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
             K   L+ +R                    +      L+Q          +   E +   
Sbjct: 2476 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2516

Query: 238  ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
            +  E     +  +  E   ++   E   R++  E++++  + + QE+   EE   L+E +
Sbjct: 2517 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2576

Query: 298  RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
            + LEE  R  L  S +++ +++ A    PN
Sbjct: 2577 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2606


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)

Query: 11   RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
            R QL +      LL    Q L+ +A+   RQ ++V   E    ++  + +  ++L  RI+
Sbjct: 2178 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2234

Query: 70   TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
              NR   + DK  T    + +A  +MK+ AE+   A  L +  A E   LR+ +  D+  
Sbjct: 2235 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2289

Query: 129  VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
             +   E  L ++++ + EAT+     + LQQ+   A EQ   LQE    + QQL  + +G
Sbjct: 2290 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2349

Query: 179  KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
               TLE +R   L ++  +  + L+V            +  +D  RF K   E  E    
Sbjct: 2350 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2405

Query: 237  TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
            TEL     +T+ +T   LE QR  ++        A  +  RE EK+  E K         
Sbjct: 2406 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2462

Query: 282  ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
               Q++  L+E   LQ+     ++ L  +   ++    +LE       A+  +   E  R
Sbjct: 2463 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2522

Query: 332  DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
             Q Q  +  E  +L A++   +++  +A++ +    + L +L+
Sbjct: 2523 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2563



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
            AQL+R    +    A+ LR E   +        R R  E    + RW+   ++ L  L  
Sbjct: 1576 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1632

Query: 88   EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
            + + + Q K  A+   + +    +        RE+RR     +  V      E EL K+ 
Sbjct: 1633 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1684

Query: 142  EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
            ++ E T    QQ+++   E + L  E +Q        + E   + R   +   +   +  
Sbjct: 1685 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1741

Query: 202  KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
            ++   R      +   +   ++    S  +K R EAE     EL E  A   A       
Sbjct: 1742 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1801

Query: 256  AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
             +++A E A R+R  E E+V +E          LK + +  L+E     E +R L ED  
Sbjct: 1802 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860

Query: 304  LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
             + + L  + +  + +       +    D   + Q GL ++      Q+E  I ALK   
Sbjct: 1861 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1920

Query: 357  AQAQDALDALCKHLARLQAD 376
             +A      L   L R++++
Sbjct: 1921 EKAAAGKAELELELGRIRSN 1940



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
            AQ + D   ++ Q  +   +E   Q   + D    R ++ E I  +    E       +L
Sbjct: 1871 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1930

Query: 86   DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
            + E   L +++ +AE  L++K    L+ A +     E  R     ++ V+  L  E E  
Sbjct: 1931 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1987

Query: 145  EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
               K AL++  ++    E+   L     QE  +QL        + L+ +    +  ++  
Sbjct: 1988 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2047

Query: 198  NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
               L+    +       L+   + +R   + AE     AE +AA   R+       + + 
Sbjct: 2048 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2107

Query: 253  ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
            E +AQ R   + A  K  +E E+  +     E+  L +     AE+++  +  E+ LR K
Sbjct: 2108 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2167

Query: 308  LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
                  +    E  T R  +E   D  +  L +E+ +L+A      ++ +Q ++ L ++ 
Sbjct: 2168 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2220

Query: 367  --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
               + L++L+A I  +  +++L  K  +T+R L   AE+
Sbjct: 2221 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2258



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)

Query: 120  RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
            ++S  D + +++ +  EL +E E ++   K LQ K    Q  +Q  LLQE Q    S   
Sbjct: 2425 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2483

Query: 178  GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
             K   L+ +R                    +      L+Q          +   E +   
Sbjct: 2484 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2524

Query: 238  ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
            +  E     +  +  E   ++   E   R++  E++++  + + QE+   EE   L+E +
Sbjct: 2525 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2584

Query: 298  RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
            + LEE  R  L  S +++ +++ A    PN
Sbjct: 2585 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2614


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 98/403 (24%), Positives = 174/403 (43%), Gaps = 56/403 (13%)

Query: 11   RFQLPDWHTNSYLLSTNAQ-LQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERID 69
            R QL +      LL    Q L+ +A+   RQ ++V   E    ++  + +  ++L  RI+
Sbjct: 2219 RLQLEETDHQKNLLDEELQRLKAEATEAARQRSQV---EEELFSVRVQMEELSKLKARIE 2275

Query: 70   TVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRE-SRRDIDV 128
              NR   + DK  T    + +A  +MK+ AE+   A  L +  A E   LR+ +  D+  
Sbjct: 2276 AENRALILRDKDNTQRFLQEEA-EKMKQVAEE---AARLSV-AAQEAARLRQLAEEDLAQ 2330

Query: 129  VKDPVEDELHKEVEVI-EATK-----KALQQKVSQAFEQLCLLQE----VQQQLNSDHRG 178
             +   E  L ++++ + EAT+     + LQQ+   A EQ   LQE    + QQL  + +G
Sbjct: 2331 QRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQG 2390

Query: 179  KMETLEIDR-GCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-AEMKAA 236
               TLE +R   L ++  +  + L+V            +  +D  RF K   E  E    
Sbjct: 2391 FQRTLEAERQRQLEMSAEAERLKLRV----AEMSRAQARAEEDAQRFRKQAEEIGEKLHR 2446

Query: 237  TELREATALTIAETNNELEAQRVATEF-------AFRKRLREMEKVYSELKW-------- 281
            TEL     +T+ +T   LE QR  ++        A  +  RE EK+  E K         
Sbjct: 2447 TELATQEKVTLVQT---LEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEM 2503

Query: 282  ---QEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLE-------ARTYRPNVELCR 331
               Q++  L+E   LQ+     ++ L  +   ++    +LE       A+  +   E  R
Sbjct: 2504 QTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQR 2563

Query: 332  DQAQYGLTDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQ 374
             Q Q  +  E  +L A++   +++  +A++ +    + L +L+
Sbjct: 2564 QQQQ--MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2604



 Score = 38.9 bits (89), Expect = 0.009
 Identities = 82/380 (21%), Positives = 145/380 (38%), Gaps = 46/380 (12%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQTIWDEHDNRTRLVERIDTVNRWKEMLDKCLTDLDA 87
            AQL+R    +    A+ LR E   +        R R  E    + RW+   ++ L  L  
Sbjct: 1617 AQLERSLQEEHVAVAQ-LREEAERRAQQQAEAERAR-EEAERELERWQLKANEALR-LRL 1673

Query: 88   EIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPV------EDELHKEV 141
            + + + Q K  A+   + +    +        RE+RR     +  V      E EL K+ 
Sbjct: 1674 QAEEVAQQKSLAQAEAEKQKEEAE--------REARRRGKAEEQAVRQRELAEQELEKQR 1725

Query: 142  EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
            ++ E T    QQ+++   E + L  E +Q        + E   + R   +   +   +  
Sbjct: 1726 QLAEGTA---QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1782

Query: 202  KVDPTR------VPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNELE 255
            ++   R      +   +   ++    S  +K R EAE     EL E  A   A       
Sbjct: 1783 ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1842

Query: 256  AQRVATEFAFRKRLREMEKVYSE----------LKWQEKNTLEEIAELQEDIRHLEED-- 303
             +++A E A R+R  E E+V +E          LK + +  L+E     E +R L ED  
Sbjct: 1843 QRQLAEEDAARQR-AEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901

Query: 304  LRTKLLSLKLSHTRLEARTYRPNVELCRD---QAQYGLTDEV----HQLEATIAALKQKL 356
             + + L  + +  + +       +    D   + Q GL ++      Q+E  I ALK   
Sbjct: 1902 FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF 1961

Query: 357  AQAQDALDALCKHLARLQAD 376
             +A      L   L R++++
Sbjct: 1962 EKAAAGKAELELELGRIRSN 1981



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 84/399 (21%), Positives = 165/399 (41%), Gaps = 34/399 (8%)

Query: 28   AQLQRDASHQIRQEARVLRNETNNQT--IWDEHDNRTRLVERIDTVNRWKEMLDKCLTDL 85
            AQ + D   ++ Q  +   +E   Q   + D    R ++ E I  +    E       +L
Sbjct: 1912 AQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL 1971

Query: 86   DAEIDALTQMKESAEQNLQAKN-LPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVI 144
            + E   L +++ +AE  L++K    L+ A +     E  R     ++ V+  L  E E  
Sbjct: 1972 ELE---LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2028

Query: 145  EATKKALQQ--KVSQAFEQLCLL-----QEVQQQLNSDHRGKMETLEIDRGCLSLNLRSP 197
               K AL++  ++    E+   L     QE  +QL        + L+ +    +  ++  
Sbjct: 2029 RQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQK 2088

Query: 198  NISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAE-----AEMKAATELREATALTIAETNN 252
               L+    +       L+   + +R   + AE     AE +AA   R+       + + 
Sbjct: 2089 EQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSA 2148

Query: 253  ELEAQ-RVATEFAFRKRLREMEKVYSELKWQEKNTLEE----IAELQEDIRHLEEDLRTK 307
            E +AQ R   + A  K  +E E+  +     E+  L +     AE+++  +  E+ LR K
Sbjct: 2149 EEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQK 2208

Query: 308  LLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVHQLEATIAALKQKLAQAQDALDAL- 366
                  +    E  T R  +E   D  +  L +E+ +L+A      ++ +Q ++ L ++ 
Sbjct: 2209 ------AQVEQELTTLRLQLEE-TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2261

Query: 367  --CKHLARLQADIACKANSMLLDTKCMDTRRKLTVPAER 403
               + L++L+A I  +  +++L  K  +T+R L   AE+
Sbjct: 2262 VQMEELSKLKARIEAENRALILRDK-DNTQRFLQEEAEK 2299



 Score = 33.5 bits (75), Expect = 0.38
 Identities = 44/210 (20%), Positives = 84/210 (40%), Gaps = 23/210 (10%)

Query: 120  RESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVS--QAFEQLCLLQEVQQQLNSDHR 177
            ++S  D + +++ +  EL +E E ++   K LQ K    Q  +Q  LLQE Q    S   
Sbjct: 2466 QQSDHDAERLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2524

Query: 178  GKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAAT 237
             K   L+ +R                    +      L+Q          +   E +   
Sbjct: 2525 EKDSLLQRERF-------------------IEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2565

Query: 238  ELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDI 297
            +  E     +  +  E   ++   E   R++  E++++  + + QE+   EE   L+E +
Sbjct: 2566 QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQL 2625

Query: 298  RHLEEDLRTKLL-SLKLSHTRLEARTYRPN 326
            + LEE  R  L  S +++ +++ A    PN
Sbjct: 2626 QLLEEQHRAALAHSEEVTASQVAATKTLPN 2655


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 76/370 (20%), Positives = 167/370 (45%), Gaps = 33/370 (8%)

Query: 57   EHDNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC 116
            E DN     ER D + + K  L+  + +++  ++     +E     L AK   L+   EC
Sbjct: 896  EQDNLNDAEERCDQLIKNKIQLEAKVKEMNERLED----EEEMNAELTAKKRKLED--EC 949

Query: 117  LTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDH 176
              L++   D+++    VE E H      E   K L ++++   E +  L + ++ L   H
Sbjct: 950  SELKKDIDDLELTLAKVEKEKH----ATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAH 1005

Query: 177  RGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAA 236
            +  ++ L+++   ++ +L    + L+    +V D   +L+Q +   R + +RA+ +++  
Sbjct: 1006 QQALDDLQVEEDKVN-SLSKSKVKLE---QQVDDLEGSLEQ-EKKVRMDLERAKRKLEGD 1060

Query: 237  TELREATALTIAETNNELEAQRVATEFAFRK---RLREMEKVYSELKWQEKNTLEEIAEL 293
             +L + + + +     +LE +    EF   +   ++ + + +  +L+ + K     I EL
Sbjct: 1061 LKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQARIEEL 1120

Query: 294  QEDI------RHLEEDLRTKLL-SLKLSHTRLEARTYRPNVEL---CRDQAQY-----GL 338
            +E++      R   E LR+ L   L+    RLE      +V++    + +A++      L
Sbjct: 1121 EEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDL 1180

Query: 339  TDEVHQLEATIAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCMDTRRKLT 398
             +   Q EAT AAL++K A +   L     +L R++  +  + +   L+   + +  +  
Sbjct: 1181 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQI 1240

Query: 399  VPAERFVPEV 408
            + A+  + +V
Sbjct: 1241 IKAKANLEKV 1250



 Score = 47.0 bits (110), Expect = 3e-05
 Identities = 68/341 (19%), Positives = 140/341 (41%), Gaps = 42/341 (12%)

Query: 41   EARVLRNETNNQTIWDEH-DNRTRLVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESA 99
            E   L++E     +  +H D+   L E+ID + R K+ L+K  ++   E+D +T    + 
Sbjct: 1181 EEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT---SNM 1237

Query: 100  EQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAF 159
            EQ ++AK                  +++ V   +ED+ ++    +E  +++L    +Q  
Sbjct: 1238 EQIIKAK-----------------ANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRA 1280

Query: 160  EQLCLLQEVQQQLNSDHRGKMETL--EIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQ 217
            +      E+ +QL      + E L  ++ RG LS   +  ++  +++          L  
Sbjct: 1281 KLQTENGELARQLE-----EKEALISQLTRGKLSYTQQMEDLKRQLE--EEGKAKNALAH 1333

Query: 218  WDDFSRFNKDRAEAEMKAATELREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYS 277
                +R + D    + +  TE +      +++ N+E+   R   E    +R  E+E+   
Sbjct: 1334 ALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKK 1393

Query: 278  ELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYG 337
            +L           A+  +D     E +  K  SL+ +  RL+       V++ R  A   
Sbjct: 1394 KL-----------AQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAA 1442

Query: 338  LTDEVHQ-LEATIAALKQKLAQAQDALDALCKHLARLQADI 377
              D+  +  +  +A  KQK  ++Q  L++  K    L  ++
Sbjct: 1443 ALDKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTEL 1483



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 74/381 (19%), Positives = 158/381 (41%), Gaps = 40/381 (10%)

Query: 7    KPSRRFQLPDWHTN-SYLLSTNAQLQRDASHQIRQEARVLRN--ETNNQTIWDEHDNRTR 63
            K   + +L D  +N   ++   A L++  S  +  +A   R   E   +++ D    R +
Sbjct: 1223 KSEFKLELDDVTSNMEQIIKAKANLEK-VSRTLEDQANEYRVKLEEAQRSLNDFTTQRAK 1281

Query: 64   LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESR 123
            L      + R  E  +  ++ L     + TQ  E  ++ L+ +    +     L  + +R
Sbjct: 1282 LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHAL--QSAR 1339

Query: 124  RDIDVVKDPVEDELHKEVEVIEATKKALQQKV-------SQAFEQLCLLQEVQQQLNSDH 176
             D D++++  E+E   + E+     KA  +         + A ++   L+E +++L    
Sbjct: 1340 HDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1399

Query: 177  RGKMETLE-IDRGCLSLNLRSPNISLKVDPTRVP-DGSTTLQQWDDFSRFNKDRAEAEMK 234
            +   E +E ++  C SL      +  +++   V  + S       D  + N D+  AE K
Sbjct: 1400 QDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWK 1459

Query: 235  AATELREATALTIAETNNELEAQRVATE-FAFRKRLREMEKVYSELKWQEKNTLEEIAEL 293
               E  ++        +++ EA+ ++TE F  +    E  +     K + KN  EEI++L
Sbjct: 1460 QKYEESQSEL-----ESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEEISDL 1514

Query: 294  QE----------DIRHLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGLTDEVH 343
             E          ++  + + L  + L L+ +    EA       ++ R Q ++      +
Sbjct: 1515 TEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEF------N 1568

Query: 344  QLEATIAALKQKLAQAQDALD 364
            Q++A I   ++KLA+  + ++
Sbjct: 1569 QIKAEI---ERKLAEKDEEME 1586



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 68/335 (20%), Positives = 141/335 (42%), Gaps = 28/335 (8%)

Query: 64   LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESR 123
            L E ++     +  ++K  +DL  E++ +++  E A            V IE    RE+ 
Sbjct: 1120 LEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGG-------ATSVQIEMNKKREA- 1171

Query: 124  RDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKME-T 182
             +   ++  +E+   +      A +K     V++  EQ+  LQ V+Q+L  +   K E  
Sbjct: 1172 -EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKE---KSEFK 1227

Query: 183  LEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREA 242
            LE+D   ++ N+    I  K +  +V   S TL+   +  R   + A+  +   T  R  
Sbjct: 1228 LELDD--VTSNMEQI-IKAKANLEKV---SRTLEDQANEYRVKLEEAQRSLNDFTTQRAK 1281

Query: 243  TALTIAETNNELEAQRVATEFAFRKRL---REMEKVYSELKWQEKNTLEEIAELQEDIRH 299
                  E   +LE +        R +L   ++ME +  +L+ +E      +A   +  RH
Sbjct: 1282 LQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLE-EEGKAKNALAHALQSARH 1340

Query: 300  LEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYGL-----TDEVHQLEATIAALKQ 354
              + LR +      +   L+    + N E+ + + +Y       T+E+ + +  +A   Q
Sbjct: 1341 DCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ 1400

Query: 355  KLAQAQDALDALCKHLARLQADIACKANSMLLDTK 389
               +A +A++A C  L + +  +  +   +++D +
Sbjct: 1401 DAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVE 1435


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 58/414 (14%)

Query: 31   QRDASHQIRQEARVLRNETNN--QTIWDEHDNRTRL-VERIDTVNRWKEMLDKCLTDLDA 87
            + D   Q++ E + +  +  +  + + +E   R +L +E++    + K++ D+ L  +D 
Sbjct: 934  EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDD 992

Query: 88   EIDALTQMKESAEQNLQAKNLPLDVAIE---CLTLRESRRDIDVVKDPVEDELHKEV--- 141
            + + L++ ++  E+ +   +L  ++A E      L + +   + +   +E  L KE    
Sbjct: 993  QNNKLSKERKLLEERIS--DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1050

Query: 142  EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
            + +E  K+ L+   S   EQ+  LQ    +L      K E L+     L   +   N +L
Sbjct: 1051 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1110

Query: 202  KVDPTRVPDGSTT-LQQWDDFSRFNKDRAEAEMKAATELREATALTIAET------NNEL 254
            K    R  +G  + LQ+  D  R  +++AE + +   E  EA    + +T        EL
Sbjct: 1111 K--KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1168

Query: 255  EAQRVATEFAFRKRL----REMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLS 310
             A+R       +K L    R  E    E++ +    +EE+ E  E  +  + +L     +
Sbjct: 1169 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1228

Query: 311  LK------------LSHTRLEARTYRPNVEL--------CRD--QAQYGLTDEVHQLEAT 348
            L+            L   + E    +  +E         C D  +A+  L D+VH+L+  
Sbjct: 1229 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1288

Query: 349  IAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCM---DTRRKLTV 399
            + ++   L +A+     L K +A L        +S L DT+ +   +TR+KL V
Sbjct: 1289 VESVTGMLNEAEGKAIKLAKDVASL--------SSQLQDTQELLQEETRQKLNV 1334



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 67/304 (22%), Positives = 132/304 (43%), Gaps = 30/304 (9%)

Query: 69   DTVNRWKEMLDKC---LTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC-LTLRESRR 124
            D + + KE   K    L +L+ +   LT+ K   ++ LQA+      A E  + L   ++
Sbjct: 859  DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918

Query: 125  DIDVVKDPVEDELHKEVE---VIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDH---RG 178
            +++ +   +E  L +E +    ++A +K + Q++    EQL   +  +Q+L  +      
Sbjct: 919  ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 978

Query: 179  KMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATE 238
            K++ LE +   +       +   K+   R+ D +T L +            E + K  T+
Sbjct: 979  KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-----------EEEKAKNLTK 1027

Query: 239  LREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIR 298
            L+      I+E    L+ +         K  +E+EK+  +L+    +  E+IA+LQ  I 
Sbjct: 1028 LKNKHESMISELEVRLKKEE--------KSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079

Query: 299  HLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYG-LTDEVHQLEATIAALKQKLA 357
             L+  L  K   L+ +  RL+    + N  L + +   G ++D    L++  AA  +   
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139

Query: 358  QAQD 361
            Q +D
Sbjct: 1140 QKRD 1143



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 68/365 (18%), Positives = 146/365 (40%), Gaps = 31/365 (8%)

Query: 20   NSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN----RTRLVERIDTVNRWK 75
            +S L  T   LQ +   ++    ++ + E    ++ D+ D     +  L   I T+N   
Sbjct: 1314 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1373

Query: 76   EMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVED 135
                K L D  + ++AL + K+  ++ ++  NL      +     +    ++  K+ ++ 
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQKEIE--NLTQQYEEKAAAYDK----LEKTKNRLQQ 1427

Query: 136  ELHKEVEVIEATKKALQ--QKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLN 193
            EL   V  ++  ++ +   +K  + F+QL   ++      +D R + E    ++   +L+
Sbjct: 1428 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1487

Query: 194  LRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNE 253
            L                    L+  ++  R NK   +AEM+     ++     + +  +E
Sbjct: 1488 LARAL-------------EEALEAKEELERTNK-MLKAEMEDLVSSKD----DVGKNVHE 1529

Query: 254  LEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKL 313
            LE  + A E    +   ++E++  EL+  E   L     +Q      E DL+ +    + 
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589

Query: 314  SHTRLEARTYRPNVELCRDQAQYGLTDEV-HQLEATIAALKQKLAQAQDALDALCKHLAR 372
               +L+ + +    EL  ++ Q  L      +LE  +  L+ +   A    +   K L +
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1649

Query: 373  LQADI 377
            LQA +
Sbjct: 1650 LQAQM 1654



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 69/338 (20%), Positives = 140/338 (41%), Gaps = 59/338 (17%)

Query: 64   LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKN---LPLDVAIECLT-- 118
            LV   D V +    L+K    L+ +++ +    E  E  LQA     L L+V ++ L   
Sbjct: 1516 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1575

Query: 119  ---------------LRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLC 163
                            R+ +R +   +  +EDE  K+  +  A KK L+           
Sbjct: 1576 FERDLQARDEQNEEKRRQLQRQLHEYETELEDE-RKQRALAAAAKKKLEGD--------- 1625

Query: 164  LLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSR 223
             L++++ Q +S  +G+ E ++         LR     +K     + D   +  +    ++
Sbjct: 1626 -LKDLELQADSAIKGREEAIK--------QLRKLQAQMKDFQRELEDARASRDEIFATAK 1676

Query: 224  FNKDRAEAEMKAATELREATALTI-----AETNNELEAQRVATEFAFRKRLREMEKVYSE 278
             N+ +A++      +L+E  A        A+   E  A+ +A+  + R  L++ ++    
Sbjct: 1677 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR---R 1733

Query: 279  LKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLK-LSHTRLEARTYRPNVELCRDQAQYG 337
            L+ +     EE+ E Q ++  + + +R      + LS+     R+     E  R Q +  
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1793

Query: 338  ---LTDEVHQLE--------ATIAALKQKLAQAQDALD 364
               L  ++H++E        +TIAAL+ K+AQ ++ ++
Sbjct: 1794 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 90/414 (21%), Positives = 175/414 (42%), Gaps = 58/414 (14%)

Query: 31   QRDASHQIRQEARVLRNETNN--QTIWDEHDNRTRL-VERIDTVNRWKEMLDKCLTDLDA 87
            + D   Q++ E + +  +  +  + + +E   R +L +E++    + K++ D+ L  +D 
Sbjct: 941  EEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDD 999

Query: 88   EIDALTQMKESAEQNLQAKNLPLDVAIE---CLTLRESRRDIDVVKDPVEDELHKEV--- 141
            + + L++ ++  E+ +   +L  ++A E      L + +   + +   +E  L KE    
Sbjct: 1000 QNNKLSKERKLLEERIS--DLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSR 1057

Query: 142  EVIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISL 201
            + +E  K+ L+   S   EQ+  LQ    +L      K E L+     L   +   N +L
Sbjct: 1058 QELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNAL 1117

Query: 202  KVDPTRVPDGSTT-LQQWDDFSRFNKDRAEAEMKAATELREATALTIAET------NNEL 254
            K    R  +G  + LQ+  D  R  +++AE + +   E  EA    + +T        EL
Sbjct: 1118 K--KIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQEL 1175

Query: 255  EAQRVATEFAFRKRL----REMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLS 310
             A+R       +K L    R  E    E++ +    +EE+ E  E  +  + +L     +
Sbjct: 1176 RAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQT 1235

Query: 311  LK------------LSHTRLEARTYRPNVEL--------CRD--QAQYGLTDEVHQLEAT 348
            L+            L   + E    +  +E         C D  +A+  L D+VH+L+  
Sbjct: 1236 LEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNE 1295

Query: 349  IAALKQKLAQAQDALDALCKHLARLQADIACKANSMLLDTKCM---DTRRKLTV 399
            + ++   L +A+     L K +A L        +S L DT+ +   +TR+KL V
Sbjct: 1296 VESVTGMLNEAEGKAIKLAKDVASL--------SSQLQDTQELLQEETRQKLNV 1341



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 67/304 (22%), Positives = 132/304 (43%), Gaps = 30/304 (9%)

Query: 69   DTVNRWKEMLDKC---LTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIEC-LTLRESRR 124
            D + + KE   K    L +L+ +   LT+ K   ++ LQA+      A E  + L   ++
Sbjct: 866  DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925

Query: 125  DIDVVKDPVEDELHKEVE---VIEATKKALQQKVSQAFEQLCLLQEVQQQLNSDH---RG 178
            +++ +   +E  L +E +    ++A +K + Q++    EQL   +  +Q+L  +      
Sbjct: 926  ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEA 985

Query: 179  KMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATE 238
            K++ LE +   +       +   K+   R+ D +T L +            E + K  T+
Sbjct: 986  KIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE-----------EEEKAKNLTK 1034

Query: 239  LREATALTIAETNNELEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIR 298
            L+      I+E    L+ +         K  +E+EK+  +L+    +  E+IA+LQ  I 
Sbjct: 1035 LKNKHESMISELEVRLKKEE--------KSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086

Query: 299  HLEEDLRTKLLSLKLSHTRLEARTYRPNVELCRDQAQYG-LTDEVHQLEATIAALKQKLA 357
             L+  L  K   L+ +  RL+    + N  L + +   G ++D    L++  AA  +   
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146

Query: 358  QAQD 361
            Q +D
Sbjct: 1147 QKRD 1150



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 68/365 (18%), Positives = 146/365 (40%), Gaps = 31/365 (8%)

Query: 20   NSYLLSTNAQLQRDASHQIRQEARVLRNETNNQTIWDEHDN----RTRLVERIDTVNRWK 75
            +S L  T   LQ +   ++    ++ + E    ++ D+ D     +  L   I T+N   
Sbjct: 1321 SSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQL 1380

Query: 76   EMLDKCLTDLDAEIDALTQMKESAEQNLQAKNLPLDVAIECLTLRESRRDIDVVKDPVED 135
                K L D  + ++AL + K+  ++ ++  NL      +     +    ++  K+ ++ 
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQKEIE--NLTQQYEEKAAAYDK----LEKTKNRLQQ 1434

Query: 136  ELHKEVEVIEATKKALQ--QKVSQAFEQLCLLQEVQQQLNSDHRGKMETLEIDRGCLSLN 193
            EL   V  ++  ++ +   +K  + F+QL   ++      +D R + E    ++   +L+
Sbjct: 1435 ELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALS 1494

Query: 194  LRSPNISLKVDPTRVPDGSTTLQQWDDFSRFNKDRAEAEMKAATELREATALTIAETNNE 253
            L                    L+  ++  R NK   +AEM+     ++     + +  +E
Sbjct: 1495 LARAL-------------EEALEAKEELERTNK-MLKAEMEDLVSSKD----DVGKNVHE 1536

Query: 254  LEAQRVATEFAFRKRLREMEKVYSELKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLKL 313
            LE  + A E    +   ++E++  EL+  E   L     +Q      E DL+ +    + 
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596

Query: 314  SHTRLEARTYRPNVELCRDQAQYGLTDEV-HQLEATIAALKQKLAQAQDALDALCKHLAR 372
               +L+ + +    EL  ++ Q  L      +LE  +  L+ +   A    +   K L +
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1656

Query: 373  LQADI 377
            LQA +
Sbjct: 1657 LQAQM 1661



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 69/338 (20%), Positives = 140/338 (41%), Gaps = 59/338 (17%)

Query: 64   LVERIDTVNRWKEMLDKCLTDLDAEIDALTQMKESAEQNLQAKN---LPLDVAIECLT-- 118
            LV   D V +    L+K    L+ +++ +    E  E  LQA     L L+V ++ L   
Sbjct: 1523 LVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQ 1582

Query: 119  ---------------LRESRRDIDVVKDPVEDELHKEVEVIEATKKALQQKVSQAFEQLC 163
                            R+ +R +   +  +EDE  K+  +  A KK L+           
Sbjct: 1583 FERDLQARDEQNEEKRRQLQRQLHEYETELEDE-RKQRALAAAAKKKLEGD--------- 1632

Query: 164  LLQEVQQQLNSDHRGKMETLEIDRGCLSLNLRSPNISLKVDPTRVPDGSTTLQQWDDFSR 223
             L++++ Q +S  +G+ E ++         LR     +K     + D   +  +    ++
Sbjct: 1633 -LKDLELQADSAIKGREEAIK--------QLRKLQAQMKDFQRELEDARASRDEIFATAK 1683

Query: 224  FNKDRAEAEMKAATELREATALTI-----AETNNELEAQRVATEFAFRKRLREMEKVYSE 278
             N+ +A++      +L+E  A        A+   E  A+ +A+  + R  L++ ++    
Sbjct: 1684 ENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKR---R 1740

Query: 279  LKWQEKNTLEEIAELQEDIRHLEEDLRTKLLSLK-LSHTRLEARTYRPNVELCRDQAQYG 337
            L+ +     EE+ E Q ++  + + +R      + LS+     R+     E  R Q +  
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQ 1800

Query: 338  ---LTDEVHQLE--------ATIAALKQKLAQAQDALD 364
               L  ++H++E        +TIAAL+ K+AQ ++ ++
Sbjct: 1801 NKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.128    0.356 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,177,257
Number of Sequences: 37866
Number of extensions: 580861
Number of successful extensions: 4684
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 58
Number of HSP's successfully gapped in prelim test: 502
Number of HSP's that attempted gapping in prelim test: 3440
Number of HSP's gapped (non-prelim): 1428
length of query: 430
length of database: 18,247,518
effective HSP length: 105
effective length of query: 325
effective length of database: 14,271,588
effective search space: 4638266100
effective search space used: 4638266100
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.