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Search of human proteins with 16418461
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16418461 mitochondrial topoisomerase I [Homo sapiens]
(601 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16418461 mitochondrial topoisomerase I [Homo sapiens] 1214 0.0
gi|11225260 DNA topoisomerase I [Homo sapiens] 863 0.0
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 46 1e-04
gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] 41 0.004
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] 41 0.004
gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens] 41 0.004
gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo sa... 39 0.014
gi|148234215 guanylate binding protein 4-like [Homo sapiens] 38 0.023
gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo sa... 38 0.023
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 38 0.031
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 38 0.031
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 38 0.031
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 38 0.031
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 38 0.031
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 38 0.031
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 38 0.031
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 38 0.031
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 38 0.031
gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo sap... 37 0.040
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 37 0.040
gi|71061468 centromere protein E [Homo sapiens] 37 0.040
gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo sap... 37 0.040
gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2 [... 37 0.052
gi|191252785 centrobin, centrosomal BRCA2 interacting protein is... 37 0.052
gi|80861396 centrobin, centrosomal BRCA2 interacting protein iso... 37 0.052
gi|195947367 golgi autoantigen, golgin subfamily a, 8B [Homo sap... 37 0.068
gi|31083099 golgi autoantigen, golgin subfamily a, 8A [Homo sapi... 37 0.068
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 37 0.068
gi|33383235 minichromosome maintenance complex component 10 isof... 37 0.068
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 37 0.068
>gi|16418461 mitochondrial topoisomerase I [Homo sapiens]
Length = 601
Score = 1214 bits (3142), Expect = 0.0
Identities = 601/601 (100%), Positives = 601/601 (100%)
Query: 1 MRVVRLLRLRAALTLLGEVPRRPASRGVPGSRRTQKGSGARWEKEKHEDGVKWRQLEHKG 60
MRVVRLLRLRAALTLLGEVPRRPASRGVPGSRRTQKGSGARWEKEKHEDGVKWRQLEHKG
Sbjct: 1 MRVVRLLRLRAALTLLGEVPRRPASRGVPGSRRTQKGSGARWEKEKHEDGVKWRQLEHKG 60
Query: 61 PYFAPPYEPLPDGVRFFYEGRPVRLSVAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRK 120
PYFAPPYEPLPDGVRFFYEGRPVRLSVAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRK
Sbjct: 61 PYFAPPYEPLPDGVRFFYEGRPVRLSVAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRK 120
Query: 121 EMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILD 180
EMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILD
Sbjct: 121 EMAVEEREVIKSLDKCDFTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILD 180
Query: 181 GHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEV 240
GHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEV
Sbjct: 181 GHQEKIGNFKIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEV 240
Query: 241 RSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRAD 300
RSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRAD
Sbjct: 241 RSDNTVTWLAAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRAD 300
Query: 301 WKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHV 360
WKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHV
Sbjct: 301 WKSREMKTRQRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHV 360
Query: 361 VEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGL 420
VEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGL
Sbjct: 361 VEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGL 420
Query: 421 TAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSM 480
TAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSM
Sbjct: 421 TAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSM 480
Query: 481 QNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQ 540
QNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQ
Sbjct: 481 QNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQ 540
Query: 541 ATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFAWALAMAGEDFE 600
ATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFAWALAMAGEDFE
Sbjct: 541 ATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFAWALAMAGEDFE 600
Query: 601 F 601
F
Sbjct: 601 F 601
>gi|11225260 DNA topoisomerase I [Homo sapiens]
Length = 765
Score = 863 bits (2230), Expect = 0.0
Identities = 402/584 (68%), Positives = 493/584 (84%), Gaps = 2/584 (0%)
Query: 18 EVPRRPASRGVPGSRRTQKGSGARWEKEKHEDGVKWRQLEHKGPYFAPPYEPLPDGVRFF 77
+VP + P QK WE+E++ +G+KW+ LEHKGP FAPPYEPLP+ V+F+
Sbjct: 184 KVPEPDNKKKKPKKEEEQKWKW--WEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKFY 241
Query: 78 YEGRPVRLSVAAEEVATFYGRMLDHEYTTKEVFRKNFFNDWRKEMAVEEREVIKSLDKCD 137
Y+G+ ++LS AEEVATF+ +MLDHEYTTKE+FRKNFF DWRKEM EE+ +I +L KCD
Sbjct: 242 YDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKCD 301
Query: 138 FTEIHRYFVDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILDGHQEKIGNFKIEPPGLF 197
FT++ +YF + ARK +S+EEK K+KEE EKL +E+G+CI+D H+E+I NFKIEPPGLF
Sbjct: 302 FTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGLF 361
Query: 198 RGRGDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVTWLAAWTESVQ 257
RGRG+HPKMGMLKRRI PED++INCS+D+K+P PP GH+WKEVR DN VTWL +WTE++Q
Sbjct: 362 RGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENIQ 421
Query: 258 NSIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTRQRAVALYF 317
SIKYIMLNP S++KGE WQK+ETARRL+ VD+IR+QYR DWKS+EMK RQRAVALYF
Sbjct: 422 GSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALYF 481
Query: 318 IDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRV 377
IDKLALRAGNEKE+GE ADTVGCCSLRVEH+ LHPE DG ++VVEFDFLGKD IRYYN+V
Sbjct: 482 IDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNKV 541
Query: 378 PVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQ 437
PVEK V+KNLQLFMENK P DDLFDRL T LNKHLQ+LM+GLTAKVFRTYNASITLQ+Q
Sbjct: 542 PVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQQ 601
Query: 438 LRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEA 497
L+ LT +++I AKILSYNRANR VAILCNHQRA P TFEKSM NLQTKI AKKEQ+A+A
Sbjct: 602 LKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLADA 661
Query: 498 RAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQVALGTSKL 557
R +L+ A+A+ K D K++ V+E K++ +++L+EQL +L VQATD+EENKQ+ALGTSKL
Sbjct: 662 RRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSKL 721
Query: 558 NYLDPRISIAWCKRFRVPVEKIYSKTQRERFAWALAMAGEDFEF 601
NYLDPRI++AWCK++ VP+EKIY+KTQRE+FAWA+ MA ED+EF
Sbjct: 722 NYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF 765
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 45.8 bits (107), Expect = 1e-04
Identities = 89/406 (21%), Positives = 163/406 (40%), Gaps = 54/406 (13%)
Query: 132 SLDKCDFTEIHRYF--VDKAAARKVLSREEKQKLKEEAEKLQQEFGYCILDGHQEKIGNF 189
S D EI+ Y +D+ R EEKQK KE ++ L+ E +L K G
Sbjct: 1826 SKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKN-TLLSQISTKDGEL 1884
Query: 190 KIEPPGLFRGRGDHPKMGMLKRRITPEDVVINCSRDSKIPEPPAGHQWKEVRSDNTVTWL 249
K+ + + KM +L ++I E SR +K+ E + K+ + + L
Sbjct: 1885 KML-------QEEVTKMNLLNQQIQEE-----LSRVTKLKE--TAEEEKDDLEERLMNQL 1930
Query: 250 AAWTESVQNSIKYIMLNPCSKLKGETAWQKFETARRLRGFVDEIRSQYRADWKSREMKTR 309
A S+ N Y +++K E + + ++ ++E + Q + E + R
Sbjct: 1931 AELNGSIGN---YCQDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIR 1987
Query: 310 QRAVALYFIDKLALRAGNEKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKD 369
+ +++K+ G +KE G + L E Q E L KD
Sbjct: 1988 KE-----YLEKIQ---GAQKEPGNKSHAKELQELLKEKQQ------------EVKQLQKD 2027
Query: 370 CIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTA-KVFRTY 428
CIRY ++ + K L+ F++ + +D + +H ++ L + KV
Sbjct: 2028 CIRYQEKISALERTVKALE-FVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVL--- 2083
Query: 429 NASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQ 488
T E R L A++ K L N+ + + + + E+ ++ + K
Sbjct: 2084 -LDDTQSEAARVL--ADNLKLKKELQSNKES-----VKSQMKQKDEDLERRLEQAEEKHL 2135
Query: 489 AKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQL 534
+K+ + E LRR + H + G+ + L KK + +++LQE L
Sbjct: 2136 KEKKNMQEKLDALRREKV-HLEETIGEIQVTLNKKDKEVQQLQENL 2180
Score = 40.8 bits (94), Expect = 0.004
Identities = 46/210 (21%), Positives = 91/210 (43%), Gaps = 29/210 (13%)
Query: 356 GCQHVVEFDFLGKDCIRYYNRVPVEKPVYKNLQLFMENKDPRDDLFDRLTTTSLNKHLQE 415
G +VV + G D R P++ +++ + N ++D+ +RL + + E
Sbjct: 7 GLANVVLHELSGDDDTDQNMRAPLDPELHQESDMEFNNTT-QEDVQERLAYAE--QLVVE 63
Query: 416 LMDGLTAKVFRTYNASITLQEQLRA----LTRAEDSIAAKILSYNRANRVVAI------- 464
L D + K + LQE+ +A + + + AK+ S N+ +
Sbjct: 64 LKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLP 123
Query: 465 --------LCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKS 516
L H +++ E ++ ++ K+Q K+E ++ +A+L +A+AE AQ +
Sbjct: 124 TEPQSEEQLSKHDKSSTEE-EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEM 182
Query: 517 RSVLEKKRRLLEK------LQEQLAQLSVQ 540
+ K++L EK LQ QL+Q +
Sbjct: 183 EEFVMMKQQLQEKEEFISTLQAQLSQTQAE 212
Score = 31.6 bits (70), Expect = 2.2
Identities = 36/165 (21%), Positives = 75/165 (45%), Gaps = 12/165 (7%)
Query: 385 KNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRA 444
+ LQ +E KD + T ++ + E M L + F TL+EQL L+RA
Sbjct: 890 ETLQQTIEEKDQQ--------VTEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRA 941
Query: 445 EDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRA 504
E++ ++ N + + N+ +P+ + S + LQ + K++ + + +L+ A
Sbjct: 942 EEAKKEQVEEDNEVSS--GLKQNYDEMSPAG-QISKEELQHEFDLLKKENEQRKRKLQAA 998
Query: 505 RAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQ 549
K SR + E+ L ++ ++++ + + EE+K+
Sbjct: 999 LINRKELLQRVSR-LEEELANLKDESKKEIPLSETERGEVEEDKE 1042
>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 40.8 bits (94), Expect = 0.004
Identities = 41/153 (26%), Positives = 72/153 (47%), Gaps = 17/153 (11%)
Query: 402 DRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRV 461
D T + K ++++ DGL A AS E L A + ++++A + S +
Sbjct: 341 DSKTLAAKEKEVKKITDGLHA----LQEASNKDAEALAAAQQHFNAVSAGLSS--NEDGA 394
Query: 462 VAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDG--KSRSV 519
A L A + K+ QT+ + + ++ A+ EL+ +AE K G K +
Sbjct: 395 EATLAGQMMACKNDISKA----QTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA 450
Query: 520 LEKKRRLLEKLQEQLAQLSVQATDKEENKQVAL 552
LE +RL EKL+ ++ +L+ EENK+ +L
Sbjct: 451 LEAVKRLKEKLEAEMKKLNY-----EENKEESL 478
>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 40.8 bits (94), Expect = 0.004
Identities = 41/153 (26%), Positives = 72/153 (47%), Gaps = 17/153 (11%)
Query: 402 DRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRV 461
D T + K ++++ DGL A AS E L A + ++++A + S +
Sbjct: 341 DSKTLAAKEKEVKKITDGLHA----LQEASNKDAEALAAAQQHFNAVSAGLSS--NEDGA 394
Query: 462 VAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDG--KSRSV 519
A L A + K+ QT+ + + ++ A+ EL+ +AE K G K +
Sbjct: 395 EATLAGQMMACKNDISKA----QTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA 450
Query: 520 LEKKRRLLEKLQEQLAQLSVQATDKEENKQVAL 552
LE +RL EKL+ ++ +L+ EENK+ +L
Sbjct: 451 LEAVKRLKEKLEAEMKKLNY-----EENKEESL 478
>gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 40.8 bits (94), Expect = 0.004
Identities = 41/153 (26%), Positives = 72/153 (47%), Gaps = 17/153 (11%)
Query: 402 DRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRV 461
D T + K ++++ DGL A AS E L A + ++++A + S +
Sbjct: 341 DSKTLAAKEKEVKKITDGLHA----LQEASNKDAEALAAAQQHFNAVSAGLSS--NEDGA 394
Query: 462 VAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDG--KSRSV 519
A L A + K+ QT+ + + ++ A+ EL+ +AE K G K +
Sbjct: 395 EATLAGQMMACKNDISKA----QTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEA 450
Query: 520 LEKKRRLLEKLQEQLAQLSVQATDKEENKQVAL 552
LE +RL EKL+ ++ +L+ EENK+ +L
Sbjct: 451 LEAVKRLKEKLEAEMKKLNY-----EENKEESL 478
>gi|156104901 ankyrin repeat domain 20 family, member A1 [Homo
sapiens]
Length = 823
Score = 38.9 bits (89), Expect = 0.014
Identities = 56/269 (20%), Positives = 108/269 (40%), Gaps = 39/269 (14%)
Query: 328 EKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPV--YK 385
E E + TV ++ + + P D H + ++CI + + + + K
Sbjct: 473 EVEAKQLEPTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDENCILKADIAILRQEICTMK 532
Query: 386 NLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAE 445
N L ENK +D + T +L K+++ + +T FR Q++L L
Sbjct: 533 NDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFR-------YQQELNDLKAEN 585
Query: 446 DSIAAKILSYNRA-NRVVAILCNHQRATPSTFEKSMQNLQT----KIQAKKEQVAEARAE 500
+ A++L + R+ A + ++Q + K ++++T K+ ++ + + E
Sbjct: 586 TRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVE 645
Query: 501 LRRARAEHKAQGD--------------------GKSRSVLEKKRRLLEKLQEQLAQLSVQ 540
+ A ++ KA+ + K+R L KK LE +Q L+Q Q
Sbjct: 646 MSSAISKVKAENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQ 705
Query: 541 ATDKEENKQ-----VALGTSKLNYLDPRI 564
+ +E Q V T K N ++ RI
Sbjct: 706 TQEMKEMYQNAEAKVNNSTGKWNCVEERI 734
>gi|148234215 guanylate binding protein 4-like [Homo sapiens]
Length = 638
Score = 38.1 bits (87), Expect = 0.023
Identities = 40/160 (25%), Positives = 64/160 (40%), Gaps = 17/160 (10%)
Query: 439 RALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKI-QAKKEQVAEA 497
+ALT E +IAAK A + +L Q+ E ++ Q I Q KK+ E
Sbjct: 479 KALTAGEKAIAAKQAKKEAAEKEQELLRQKQKEQQQMMEAQERSFQENIAQLKKKMERER 538
Query: 498 RAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQL--SVQATDKEENKQVAL--- 552
+R R + + E + + E L E++ +L ++A + EE +
Sbjct: 539 ENYMRELRKMLSHKMKVLEELLTEGFKEIFESLNEEINRLKEQIEAAENEEPSVFSQILD 598
Query: 553 -----------GTSKLNYLDPRISIAWCKRFRVPVEKIYS 581
G +KL L +I + C R R P +KI S
Sbjct: 599 VAGSIFIAALPGAAKLVDLGMKILSSLCNRLRNPGKKIIS 638
>gi|149363679 ankyrin repeat domain 20 family, member A4 [Homo
sapiens]
Length = 823
Score = 38.1 bits (87), Expect = 0.023
Identities = 56/269 (20%), Positives = 107/269 (39%), Gaps = 39/269 (14%)
Query: 328 EKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPV--YK 385
E E + TV ++ + + P D H + ++CI + + + + K
Sbjct: 473 EVEAKQLEPTVQSLEMKSKTARNTPNWDFHNHEEMKGLMDENCILKADIAILRQEICTMK 532
Query: 386 NLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAE 445
N L ENK +D + T +L K+++ + +T FR Q++L L
Sbjct: 533 NDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFR-------YQQELNDLKAEN 585
Query: 446 DSIAAKILSYNRA-NRVVAILCNHQRATPSTFEKSMQNLQT----KIQAKKEQVAEARAE 500
+ A++L + R+ A + ++Q + K ++++T K+ ++ Q + E
Sbjct: 586 TRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTQDVSVQVE 645
Query: 501 LRRARAEHKAQGD--------------------GKSRSVLEKKRRLLEKLQEQLAQLSVQ 540
+ A ++ K + + K+R L KK LE +Q L+Q Q
Sbjct: 646 MSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNNLSQTQQQ 705
Query: 541 ATDKEENKQ-----VALGTSKLNYLDPRI 564
+ +E Q V T K N ++ RI
Sbjct: 706 TQEMKEMYQNAEAKVNNSTGKWNCVEERI 734
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 37.7 bits (86), Expect = 0.031
Identities = 29/123 (23%), Positives = 56/123 (45%), Gaps = 5/123 (4%)
Query: 429 NASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNL--QTK 486
NA ++E + ++ ++ S N+A + L A + E ++ Q +
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 487 IQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEE 546
++ K+EQ AEL++A E + + + + ++ LE+L EQL Q + E+
Sbjct: 1168 LRTKREQEV---AELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK 1224
Query: 547 NKQ 549
NKQ
Sbjct: 1225 NKQ 1227
Score = 33.1 bits (74), Expect = 0.75
Identities = 38/191 (19%), Positives = 75/191 (39%), Gaps = 32/191 (16%)
Query: 393 NKDPRDDLFDRLTTT--SLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAA 450
N + + FD+L S++ E D A+ +++L L A++
Sbjct: 1445 NLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEE--- 1501
Query: 451 KILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKA 510
+ R N+ + ++ K++ L+ +A ++QV E R +L E +A
Sbjct: 1502 ----FERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQA 1557
Query: 511 QGDGKSRSVL--------------------EKKRRLLEKLQEQLAQLSVQATDKEENKQV 550
D K R + E+K+RLL K Q+ +L + D+ + + +
Sbjct: 1558 TEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK---QVRELEAELEDERKQRAL 1614
Query: 551 ALGTSKLNYLD 561
A+ + K +D
Sbjct: 1615 AVASKKKMEID 1625
Score = 31.6 bits (70), Expect = 2.2
Identities = 25/87 (28%), Positives = 41/87 (47%), Gaps = 11/87 (12%)
Query: 477 EKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLE-------- 528
E S Q + + +AK + E+ + E + + + K+R LEK +R L+
Sbjct: 1010 ECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQD 1069
Query: 529 ---KLQEQLAQLSVQATDKEENKQVAL 552
+LQ Q+ +L +Q KEE Q AL
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQGAL 1096
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 37.7 bits (86), Expect = 0.031
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 13/88 (14%)
Query: 477 EKSMQNLQTKIQAKKEQVAEARAELRRARAE------HKAQGDGKSRSVLEKKRRLLE-- 528
E+ + LQ + A ++ E AEL + RAE KA+ + +SRS EK ++ LE
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 529 -----KLQEQLAQLSVQATDKEENKQVA 551
+L E+ A+L A + + +Q+A
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLA 1820
Score = 32.3 bits (72), Expect = 1.3
Identities = 29/133 (21%), Positives = 57/133 (42%), Gaps = 19/133 (14%)
Query: 435 QEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQV 494
+E+ RAL E+ ++ + R+ R E + ++ + ++Q+K+
Sbjct: 1529 REKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 495 AEARAELRRA-------------RAEHKAQGDGKSRSVLEKKRRLLEKLQ---EQLAQLS 538
AE A+L R+ AE +AQ ++ E+ R LE+ Q + +L
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 539 VQATDKEENKQVA 551
+QA + + K +A
Sbjct: 1646 LQAEEVAQQKSLA 1658
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 37.7 bits (86), Expect = 0.031
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 13/88 (14%)
Query: 477 EKSMQNLQTKIQAKKEQVAEARAELRRARAE------HKAQGDGKSRSVLEKKRRLLE-- 528
E+ + LQ + A ++ E AEL + RAE KA+ + +SRS EK ++ LE
Sbjct: 1737 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1796
Query: 529 -----KLQEQLAQLSVQATDKEENKQVA 551
+L E+ A+L A + + +Q+A
Sbjct: 1797 AGRFRELAEEAARLRALAEEAKRQRQLA 1824
Score = 32.3 bits (72), Expect = 1.3
Identities = 29/133 (21%), Positives = 57/133 (42%), Gaps = 19/133 (14%)
Query: 435 QEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQV 494
+E+ RAL E+ ++ + R+ R E + ++ + ++Q+K+
Sbjct: 1533 REKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1589
Query: 495 AEARAELRRA-------------RAEHKAQGDGKSRSVLEKKRRLLEKLQ---EQLAQLS 538
AE A+L R+ AE +AQ ++ E+ R LE+ Q + +L
Sbjct: 1590 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1649
Query: 539 VQATDKEENKQVA 551
+QA + + K +A
Sbjct: 1650 LQAEEVAQQKSLA 1662
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 37.7 bits (86), Expect = 0.031
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 13/88 (14%)
Query: 477 EKSMQNLQTKIQAKKEQVAEARAELRRARAE------HKAQGDGKSRSVLEKKRRLLE-- 528
E+ + LQ + A ++ E AEL + RAE KA+ + +SRS EK ++ LE
Sbjct: 1733 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1792
Query: 529 -----KLQEQLAQLSVQATDKEENKQVA 551
+L E+ A+L A + + +Q+A
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQRQLA 1820
Score = 32.3 bits (72), Expect = 1.3
Identities = 29/133 (21%), Positives = 57/133 (42%), Gaps = 19/133 (14%)
Query: 435 QEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQV 494
+E+ RAL E+ ++ + R+ R E + ++ + ++Q+K+
Sbjct: 1529 REKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1585
Query: 495 AEARAELRRA-------------RAEHKAQGDGKSRSVLEKKRRLLEKLQ---EQLAQLS 538
AE A+L R+ AE +AQ ++ E+ R LE+ Q + +L
Sbjct: 1586 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1645
Query: 539 VQATDKEENKQVA 551
+QA + + K +A
Sbjct: 1646 LQAEEVAQQKSLA 1658
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 37.7 bits (86), Expect = 0.031
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 13/88 (14%)
Query: 477 EKSMQNLQTKIQAKKEQVAEARAELRRARAE------HKAQGDGKSRSVLEKKRRLLE-- 528
E+ + LQ + A ++ E AEL + RAE KA+ + +SRS EK ++ LE
Sbjct: 1701 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1760
Query: 529 -----KLQEQLAQLSVQATDKEENKQVA 551
+L E+ A+L A + + +Q+A
Sbjct: 1761 AGRFRELAEEAARLRALAEEAKRQRQLA 1788
Score = 32.3 bits (72), Expect = 1.3
Identities = 29/133 (21%), Positives = 57/133 (42%), Gaps = 19/133 (14%)
Query: 435 QEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQV 494
+E+ RAL E+ ++ + R+ R E + ++ + ++Q+K+
Sbjct: 1497 REKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1553
Query: 495 AEARAELRRA-------------RAEHKAQGDGKSRSVLEKKRRLLEKLQ---EQLAQLS 538
AE A+L R+ AE +AQ ++ E+ R LE+ Q + +L
Sbjct: 1554 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1613
Query: 539 VQATDKEENKQVA 551
+QA + + K +A
Sbjct: 1614 LQAEEVAQQKSLA 1626
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 37.7 bits (86), Expect = 0.031
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 13/88 (14%)
Query: 477 EKSMQNLQTKIQAKKEQVAEARAELRRARAE------HKAQGDGKSRSVLEKKRRLLE-- 528
E+ + LQ + A ++ E AEL + RAE KA+ + +SRS EK ++ LE
Sbjct: 1870 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929
Query: 529 -----KLQEQLAQLSVQATDKEENKQVA 551
+L E+ A+L A + + +Q+A
Sbjct: 1930 AGRFRELAEEAARLRALAEEAKRQRQLA 1957
Score = 32.3 bits (72), Expect = 1.3
Identities = 29/133 (21%), Positives = 57/133 (42%), Gaps = 19/133 (14%)
Query: 435 QEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQV 494
+E+ RAL E+ ++ + R+ R E + ++ + ++Q+K+
Sbjct: 1666 REKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1722
Query: 495 AEARAELRRA-------------RAEHKAQGDGKSRSVLEKKRRLLEKLQ---EQLAQLS 538
AE A+L R+ AE +AQ ++ E+ R LE+ Q + +L
Sbjct: 1723 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1782
Query: 539 VQATDKEENKQVA 551
+QA + + K +A
Sbjct: 1783 LQAEEVAQQKSLA 1795
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 37.7 bits (86), Expect = 0.031
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 13/88 (14%)
Query: 477 EKSMQNLQTKIQAKKEQVAEARAELRRARAE------HKAQGDGKSRSVLEKKRRLLE-- 528
E+ + LQ + A ++ E AEL + RAE KA+ + +SRS EK ++ LE
Sbjct: 1711 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770
Query: 529 -----KLQEQLAQLSVQATDKEENKQVA 551
+L E+ A+L A + + +Q+A
Sbjct: 1771 AGRFRELAEEAARLRALAEEAKRQRQLA 1798
Score = 32.3 bits (72), Expect = 1.3
Identities = 29/133 (21%), Positives = 57/133 (42%), Gaps = 19/133 (14%)
Query: 435 QEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQV 494
+E+ RAL E+ ++ + R+ R E + ++ + ++Q+K+
Sbjct: 1507 REKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1563
Query: 495 AEARAELRRA-------------RAEHKAQGDGKSRSVLEKKRRLLEKLQ---EQLAQLS 538
AE A+L R+ AE +AQ ++ E+ R LE+ Q + +L
Sbjct: 1564 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1623
Query: 539 VQATDKEENKQVA 551
+QA + + K +A
Sbjct: 1624 LQAEEVAQQKSLA 1636
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 37.7 bits (86), Expect = 0.031
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 13/88 (14%)
Query: 477 EKSMQNLQTKIQAKKEQVAEARAELRRARAE------HKAQGDGKSRSVLEKKRRLLE-- 528
E+ + LQ + A ++ E AEL + RAE KA+ + +SRS EK ++ LE
Sbjct: 1719 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1778
Query: 529 -----KLQEQLAQLSVQATDKEENKQVA 551
+L E+ A+L A + + +Q+A
Sbjct: 1779 AGRFRELAEEAARLRALAEEAKRQRQLA 1806
Score = 32.3 bits (72), Expect = 1.3
Identities = 29/133 (21%), Positives = 57/133 (42%), Gaps = 19/133 (14%)
Query: 435 QEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQV 494
+E+ RAL E+ ++ + R+ R E + ++ + ++Q+K+
Sbjct: 1515 REKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1571
Query: 495 AEARAELRRA-------------RAEHKAQGDGKSRSVLEKKRRLLEKLQ---EQLAQLS 538
AE A+L R+ AE +AQ ++ E+ R LE+ Q + +L
Sbjct: 1572 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1631
Query: 539 VQATDKEENKQVA 551
+QA + + K +A
Sbjct: 1632 LQAEEVAQQKSLA 1644
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 37.7 bits (86), Expect = 0.031
Identities = 27/88 (30%), Positives = 45/88 (51%), Gaps = 13/88 (14%)
Query: 477 EKSMQNLQTKIQAKKEQVAEARAELRRARAE------HKAQGDGKSRSVLEKKRRLLE-- 528
E+ + LQ + A ++ E AEL + RAE KA+ + +SRS EK ++ LE
Sbjct: 1760 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1819
Query: 529 -----KLQEQLAQLSVQATDKEENKQVA 551
+L E+ A+L A + + +Q+A
Sbjct: 1820 AGRFRELAEEAARLRALAEEAKRQRQLA 1847
Score = 32.3 bits (72), Expect = 1.3
Identities = 29/133 (21%), Positives = 57/133 (42%), Gaps = 19/133 (14%)
Query: 435 QEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQV 494
+E+ RAL E+ ++ + R+ R E + ++ + ++Q+K+
Sbjct: 1556 REKQRALQALEE---LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF 1612
Query: 495 AEARAELRRA-------------RAEHKAQGDGKSRSVLEKKRRLLEKLQ---EQLAQLS 538
AE A+L R+ AE +AQ ++ E+ R LE+ Q + +L
Sbjct: 1613 AEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLR 1672
Query: 539 VQATDKEENKQVA 551
+QA + + K +A
Sbjct: 1673 LQAEEVAQQKSLA 1685
>gi|60460920 ankyrin repeat domain 20 family, member A3 [Homo
sapiens]
Length = 823
Score = 37.4 bits (85), Expect = 0.040
Identities = 55/269 (20%), Positives = 107/269 (39%), Gaps = 39/269 (14%)
Query: 328 EKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPV--YK 385
E E + TV ++ + + P D H + ++CI + + + + K
Sbjct: 473 EVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMK 532
Query: 386 NLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAE 445
N L ENK +D + T +L K+++ + +T FR Q++L L
Sbjct: 533 NDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFR-------YQQELNYLKAEN 585
Query: 446 DSIAAKILSYNRA-NRVVAILCNHQRATPSTFEKSMQNLQT----KIQAKKEQVAEARAE 500
+ A++L + R+ A + ++Q + K ++++T K+ ++ + + E
Sbjct: 586 TRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVE 645
Query: 501 LRRARAEHKAQGD--------------------GKSRSVLEKKRRLLEKLQEQLAQLSVQ 540
+ A ++ K + + K+R L KK LE +Q L+Q Q
Sbjct: 646 MSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQ 705
Query: 541 ATDKEENKQ-----VALGTSKLNYLDPRI 564
+ +E Q V T K N ++ RI
Sbjct: 706 TQEMKEMYQNAEAKVNNSTGKWNCVEERI 734
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 37.4 bits (85), Expect = 0.040
Identities = 33/120 (27%), Positives = 62/120 (51%), Gaps = 14/120 (11%)
Query: 433 TLQEQLRALTRAE-DSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKK 491
T+ Q TRA+ D ++AK + +R + R E+ ++ L+TKI A K
Sbjct: 226 TIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMK 285
Query: 492 EQVAEARAE-----LRRARAEHKAQ-------GDGKSRS-VLEKKRRLLEKLQEQLAQLS 538
E+ + AE +R + E KA+ G+ + R +L+++++LLEK++E+ +L+
Sbjct: 286 EEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELA 345
Score = 31.2 bits (69), Expect = 2.9
Identities = 58/249 (23%), Positives = 97/249 (38%), Gaps = 42/249 (16%)
Query: 385 KNLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRA 444
K+ QL +D RD + D + + ++EL ++A S QEQ++ T+
Sbjct: 252 KSRQLRDAQQDARDKMED------IERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKL 305
Query: 445 EDSIAAKILSYNRANRVVA---ILCNHQRATPSTFEKSMQNLQT--KIQAKKEQVAEARA 499
E + AK L A +L Q+ EK + +T K + KE+ A
Sbjct: 306 E--LKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIA 363
Query: 500 ELRRARAE----HKAQGDGKSRSVLEKKRRLLEK-----------LQEQLAQLSVQATDK 544
L +A E + QG G + E++ + ++K + Q+A + D
Sbjct: 364 RLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDT 423
Query: 545 EENKQVALG-----TSKLNYLDPRISIAWCKRFRVPVEKIYSKTQRERFAW--------A 591
E NK+ L LN + R+ K + V +K +++R + W A
Sbjct: 424 EANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSER-NYLWREENAEQQA 482
Query: 592 LAMAGEDFE 600
LA ED E
Sbjct: 483 LAAKREDLE 491
Score = 29.6 bits (65), Expect = 8.3
Identities = 34/174 (19%), Positives = 80/174 (45%), Gaps = 29/174 (16%)
Query: 409 LNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNH 468
LN++L+ ++ + ++ + N ++ Q R + DSI +++ +L
Sbjct: 696 LNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEM----------KMLKEK 745
Query: 469 QRATPSTF---EKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSVLEKKRR 525
++ + TF ++S+Q+L+ + A + +AEL D S+ LE ++R
Sbjct: 746 RQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGT---------DLLSQLSLEDQKR 796
Query: 526 LLEKLQEQLAQLSVQATDKEENKQVALGTSKLNYLDPRISIAWCKRFRVPVEKI 579
++ L +++ QL ++EN+Q+ KL + R+ + R ++++
Sbjct: 797 -VDALNDEIRQL------QQENRQLLNERIKLEGIITRVETYLNENLRKRLDQV 843
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 37.4 bits (85), Expect = 0.040
Identities = 45/194 (23%), Positives = 74/194 (38%), Gaps = 35/194 (18%)
Query: 391 MENKDPRDDLFDRLTTT--SLNKHLQELMDGLTAKVFRTYNASITLQEQLRA----LTRA 444
ME P+D R+ L+K LQE D + + V + + LQE L++ L
Sbjct: 1406 MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKS-VAKEKDDLQRLQEVLQSESDQLKEN 1464
Query: 445 EDSIAAKILSYNRANRVVAILCNHQRATP--------------STFEKSMQNLQTKIQAK 490
I AK L +V Q T ST +K ++ + K+Q K
Sbjct: 1465 IKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNK 1524
Query: 491 KEQVAEARAELR--------------RARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQ 536
+++ E + + EH+ D +S+ K L +LQE +
Sbjct: 1525 IQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEE 1584
Query: 537 LSVQATDKEENKQV 550
+ + +KEE K+V
Sbjct: 1585 IQIMIKEKEEMKRV 1598
Score = 31.6 bits (70), Expect = 2.2
Identities = 31/169 (18%), Positives = 72/169 (42%), Gaps = 23/169 (13%)
Query: 397 RDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYN 456
+D LF + H + + GL ++ +T + T Q ++ + + + +
Sbjct: 777 KDKLFSEVV------HKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFE 830
Query: 457 RANRVVAILCNHQRATPST---------FEKSMQNLQTKIQAKKEQVAEARAELRRARAE 507
+ ++V L ++R F+ S+ L+T++ K +++ E E++ E
Sbjct: 831 QKYKMV--LEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNE 888
Query: 508 HKA------QGDGKSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQV 550
+ D ++V +K + EKLQ+ L ++ +K++ KQ+
Sbjct: 889 MEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQL 937
>gi|60115723 ankyrin repeat domain 20 family, member A2 [Homo
sapiens]
Length = 823
Score = 37.4 bits (85), Expect = 0.040
Identities = 55/269 (20%), Positives = 107/269 (39%), Gaps = 39/269 (14%)
Query: 328 EKEDGEAADTVGCCSLRVEHVQLHPEADGCQHVVEFDFLGKDCIRYYNRVPVEKPV--YK 385
E E + TV ++ + + P D H + ++CI + + + + K
Sbjct: 473 EVEAKQLEPTVQSLEMKSKTARNTPNRDFHNHEEMKGLMDENCILKADIAILRQEICTMK 532
Query: 386 NLQLFMENKDPRDDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAE 445
N L ENK +D + T +L K+++ + +T FR Q++L L
Sbjct: 533 NDNLEKENKYLKDIKIVKETNAALEKYIKLNEEMITETAFR-------YQQELNDLKAEN 585
Query: 446 DSIAAKILSYNRA-NRVVAILCNHQRATPSTFEKSMQNLQT----KIQAKKEQVAEARAE 500
+ A++L + R+ A + ++Q + K ++++T K+ ++ + + E
Sbjct: 586 TRLNAELLKEKESKKRLEADIESYQSRLAAAISKHSESVKTERNLKLALERTRDVSVQVE 645
Query: 501 LRRARAEHKAQGD--------------------GKSRSVLEKKRRLLEKLQEQLAQLSVQ 540
+ A ++ K + + K+R L KK LE +Q L+Q Q
Sbjct: 646 MSSAISKVKDENEFLTEQLSETQIKFNALKDKFRKTRDSLRKKSLALETVQNDLSQTQQQ 705
Query: 541 ATDKEENKQ-----VALGTSKLNYLDPRI 564
+ +E Q V T K N ++ RI
Sbjct: 706 TQEMKEMYQNAEAKVNNSTGKWNCVEERI 734
>gi|224809410 Homer, neuronal immediate early gene, 3 isoform 2
[Homo sapiens]
Length = 358
Score = 37.0 bits (84), Expect = 0.052
Identities = 31/106 (29%), Positives = 51/106 (48%), Gaps = 6/106 (5%)
Query: 436 EQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVA 495
EQL AL + +D + S R A+ + T + L+ +++A + +
Sbjct: 258 EQLEALVQTKDQEIQTLKSQTGGPRE-ALEAAEREETQQKVQTRNAELEHQLRAMERSLE 316
Query: 496 EARAELRRARAEHKAQGDGKSRSVLEKKRRLLEKLQEQLAQLSVQA 541
EARAE RARAE G++ +L+ L +L+E LA+L+ A
Sbjct: 317 EARAERERARAE-----VGRAAQLLDVSLFELSELREGLARLAEAA 357
>gi|191252785 centrobin, centrosomal BRCA2 interacting protein
isoform alpha [Homo sapiens]
Length = 903
Score = 37.0 bits (84), Expect = 0.052
Identities = 35/145 (24%), Positives = 65/145 (44%), Gaps = 11/145 (7%)
Query: 410 NKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQ 469
N+H E + L A +T +Q +TR E S++ + + NR + Q
Sbjct: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL----Q 302
Query: 470 RATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARA----EHKAQGDGKSRSVLEKKRR 525
+ T E+ Q L +++A++++ + E ARA EH+ R+ LE++R+
Sbjct: 303 QRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHREL--ETLRAALEEERQ 360
Query: 526 LLEKLQEQLAQLSVQATDKEENKQV 550
+ + QL + QA +E Q+
Sbjct: 361 TWAQQEHQLKE-HYQALQEESQAQL 384
>gi|80861396 centrobin, centrosomal BRCA2 interacting protein
isoform beta [Homo sapiens]
Length = 925
Score = 37.0 bits (84), Expect = 0.052
Identities = 35/145 (24%), Positives = 65/145 (44%), Gaps = 11/145 (7%)
Query: 410 NKHLQELMDGLTAKVFRTYNASITLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQ 469
N+H E + L A +T +Q +TR E S++ + + NR + Q
Sbjct: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL----Q 302
Query: 470 RATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARA----EHKAQGDGKSRSVLEKKRR 525
+ T E+ Q L +++A++++ + E ARA EH+ R+ LE++R+
Sbjct: 303 QRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHREL--ETLRAALEEERQ 360
Query: 526 LLEKLQEQLAQLSVQATDKEENKQV 550
+ + QL + QA +E Q+
Sbjct: 361 TWAQQEHQLKE-HYQALQEESQAQL 384
>gi|195947367 golgi autoantigen, golgin subfamily a, 8B [Homo
sapiens]
Length = 603
Score = 36.6 bits (83), Expect = 0.068
Identities = 28/111 (25%), Positives = 50/111 (45%), Gaps = 1/111 (0%)
Query: 443 RAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELR 502
+AE + +I N + + H + + FE+ ++L ++Q +++ E L
Sbjct: 118 KAERELEGQIQRLNTEKKKLNTDLYHMKHSLRYFEEESKDLAGRLQRSSQRIGELEWSLC 177
Query: 503 RARAEHKAQGDG-KSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQVAL 552
A K + DG SRS KR+L + ++EQ+ KE K+V L
Sbjct: 178 AVAATQKKKPDGFSSRSKALLKRQLEQSIREQILLKGHVTQLKESLKEVQL 228
>gi|31083099 golgi autoantigen, golgin subfamily a, 8A [Homo
sapiens]
Length = 603
Score = 36.6 bits (83), Expect = 0.068
Identities = 28/111 (25%), Positives = 50/111 (45%), Gaps = 1/111 (0%)
Query: 443 RAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELR 502
+AE + +I N + + H + + FE+ ++L ++Q +++ E L
Sbjct: 118 KAERELEGQIQRLNTEKKKLNTDLYHMKHSLRYFEEESKDLAGRLQRSSQRIGELEWSLC 177
Query: 503 RARAEHKAQGDG-KSRSVLEKKRRLLEKLQEQLAQLSVQATDKEENKQVAL 552
A K + DG SRS KR+L + ++EQ+ KE K+V L
Sbjct: 178 AVAATQKKKPDGFSSRSKALLKRQLEQSIREQILLKGHVTQLKESLKEVQL 228
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 36.6 bits (83), Expect = 0.068
Identities = 32/151 (21%), Positives = 67/151 (44%), Gaps = 13/151 (8%)
Query: 410 NKHLQELMDGLTAKVFRTYNASIT----------LQEQLRALTRAEDSIAAKILSYNRAN 459
+++++EL A Y +IT LQE+LR + I + R
Sbjct: 158 DRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKL 217
Query: 460 RVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELRRARAEHKAQGDGKSRSV 519
L + +T ++ M + +++ +++++ + ++ R + E + +GK R
Sbjct: 218 ERAKFLL--PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR-QEERLREQEGKMREQ 274
Query: 520 LEKKRRLLEKLQEQLAQLSVQATDKEENKQV 550
EK RR ++L+EQ +L Q + E K++
Sbjct: 275 EEKMRRQEKRLREQEKELREQEKELREQKKL 305
>gi|33383235 minichromosome maintenance complex component 10 isoform
2 [Homo sapiens]
Length = 874
Score = 36.6 bits (83), Expect = 0.068
Identities = 48/186 (25%), Positives = 84/186 (45%), Gaps = 16/186 (8%)
Query: 385 KNLQLFMENKDPR--DDLFDRLTTTSLNKHLQELMDGLTAKVFRTYNASITLQEQLRALT 442
+N L EN +P D+LFD + +E DG T + TL + LT
Sbjct: 28 ENNFLTRENGEPDAFDELFD--ADGDGESYTEEADDGETGETRDEKENLATLFGDMEDLT 85
Query: 443 RAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKEQVAEARAELR 502
E+ A S + NRV+ + T ++ ++NLQ +++A +EQ+ +
Sbjct: 86 DEEEVPA----SQSTENRVLPAPAPRREKTNEELQEELRNLQEQMKALQEQLKVTTIKQT 141
Query: 503 RARAEHKAQGDGKSRSVLEKKRRLLEKLQEQL---AQLSVQATDKEENKQVALGTSKLNY 559
+ A + + R L+++R ++++QE A+L V A + K+VA T K +
Sbjct: 142 ASPARLQKSPEKSPRPPLKERR--VQRIQESTCFSAELDVPALPR--TKRVA-RTPKASP 196
Query: 560 LDPRIS 565
DP+ S
Sbjct: 197 PDPKSS 202
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 36.6 bits (83), Expect = 0.068
Identities = 40/130 (30%), Positives = 61/130 (46%), Gaps = 20/130 (15%)
Query: 433 TLQEQLRALTRAEDSIAAKILSYNRANRVVAILCNHQRATPSTFEKSMQNLQTKIQAKKE 492
+LQ+ L L+ +S+A L NR +VA L + A ++ Q T + ++E
Sbjct: 733 SLQDSLSKLSALNESLAQDKLDLNR---LVAQLEEEKSALQGRQRQAEQEA-TVAREEQE 788
Query: 493 QVAEARAELRRARAEHKAQGDGKSRSVLEKKRRLLEK-----------LQEQLAQLSVQA 541
++ E R E AR QG S V E+ + LE+ LQEQLAQLS Q
Sbjct: 789 RLEELRLEQEVAR-----QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQL 843
Query: 542 TDKEENKQVA 551
+ +E+ + A
Sbjct: 844 SGREQELEQA 853
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,071,560
Number of Sequences: 37866
Number of extensions: 1087657
Number of successful extensions: 5305
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 19
Number of HSP's successfully gapped in prelim test: 227
Number of HSP's that attempted gapping in prelim test: 4718
Number of HSP's gapped (non-prelim): 785
length of query: 601
length of database: 18,247,518
effective HSP length: 108
effective length of query: 493
effective length of database: 14,157,990
effective search space: 6979889070
effective search space used: 6979889070
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.