Search of human proteins with 16332358

Search of human proteins with 16332358

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins)
isoform 2 [Homo sapiens]
         (782 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1566   0.0  
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]   1540   0.0  
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1531   0.0  
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1524   0.0  
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]   1513   0.0  
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1494   0.0  
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1463   0.0  
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...  1051   0.0  
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      362   e-99 
gi|169161522 PREDICTED: similar to cell division cycle 2-like 1 ...   305   8e-83
gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]      303   4e-82
gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]      290   3e-78
gi|239747195 PREDICTED: similar to PITSLRE protein kinase beta S...   289   6e-78
gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]      288   1e-77
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   271   1e-72
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        270   3e-72
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             254   2e-67
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           252   8e-67
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]    252   1e-66
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]    252   1e-66
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   246   8e-65
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   246   8e-65
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   241   2e-63
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   240   3e-63
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   240   4e-63
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        239   5e-63
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          239   5e-63
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]        234   2e-61
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    230   3e-60
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]                 229   1e-59

>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 1566 bits (4055), Expect = 0.0
 Identities = 782/782 (100%), Positives = 782/782 (100%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK 120
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK 120

Query: 121 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 180
           HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
Sbjct: 121 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 180

Query: 181 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 240
           MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
Sbjct: 181 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 240

Query: 241 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 300
           ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
Sbjct: 241 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 300

Query: 301 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 360
           EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
Sbjct: 301 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 360

Query: 361 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 420
           ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR
Sbjct: 361 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 420

Query: 421 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 480
           SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
Sbjct: 421 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 480

Query: 481 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 540
           HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
Sbjct: 481 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 540

Query: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 600
           HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK
Sbjct: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 600

Query: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660
           EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK
Sbjct: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660

Query: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 720
           MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
Sbjct: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 720

Query: 721 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 780
           MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
Sbjct: 721 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 780

Query: 781 KF 782
           KF
Sbjct: 781 KF 782


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 1540 bits (3986), Expect = 0.0
 Identities = 772/782 (98%), Positives = 773/782 (98%), Gaps = 2/782 (0%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDH MEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK 120
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK RH SHSAEGGK
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGK 120

Query: 121 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 180
           HARVKE  REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
Sbjct: 121 HARVKE--REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 178

Query: 181 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 240
           MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
Sbjct: 179 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 238

Query: 241 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 300
           ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
Sbjct: 239 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 298

Query: 301 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 360
           EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
Sbjct: 299 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 358

Query: 361 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 420
           ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL PIELKQELPKYLPALQGCR
Sbjct: 359 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCR 418

Query: 421 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 480
           SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
Sbjct: 419 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 478

Query: 481 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 540
           HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
Sbjct: 479 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 538

Query: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 600
           HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT WYRAPELLLGAK
Sbjct: 539 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 598

Query: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660
           EYSTAVDMWSVGCIFGELLTQKPLFPG SEIDQINKVFK+LGTPSEKIWPGYSELP VKK
Sbjct: 599 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 658

Query: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 720
           MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
Sbjct: 659 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 718

Query: 721 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 780
           MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
Sbjct: 719 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 778

Query: 781 KF 782
           KF
Sbjct: 779 KF 780


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 1531 bits (3965), Expect = 0.0
 Identities = 770/782 (98%), Positives = 770/782 (98%), Gaps = 11/782 (1%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDH MEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK 120
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK           K
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-----------K 109

Query: 121 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 180
           HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
Sbjct: 110 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 169

Query: 181 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 240
           MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
Sbjct: 170 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 229

Query: 241 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 300
           ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
Sbjct: 230 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 289

Query: 301 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 360
           EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
Sbjct: 290 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 349

Query: 361 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 420
           ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR
Sbjct: 350 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 409

Query: 421 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 480
           SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
Sbjct: 410 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 469

Query: 481 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 540
           HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
Sbjct: 470 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 529

Query: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 600
           HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK
Sbjct: 530 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 589

Query: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660
           EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK
Sbjct: 590 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 649

Query: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 720
           MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
Sbjct: 650 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 709

Query: 721 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 780
           MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
Sbjct: 710 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 769

Query: 781 KF 782
           KF
Sbjct: 770 KF 771


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 1524 bits (3945), Expect = 0.0
 Identities = 770/791 (97%), Positives = 770/791 (97%), Gaps = 20/791 (2%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDH MEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK 120
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK           K
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK-----------K 109

Query: 121 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER---------DRLEQL 171
           HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER         DRLEQL
Sbjct: 110 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQL 169

Query: 172 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 231
           ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW
Sbjct: 170 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 229

Query: 232 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 291
           SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE
Sbjct: 230 SRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSE 289

Query: 292 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 351
           EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE
Sbjct: 290 EEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 349

Query: 352 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK 411
           NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK
Sbjct: 350 NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPK 409

Query: 412 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR 471
           YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR
Sbjct: 410 YLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLR 469

Query: 472 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI 531
           EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI
Sbjct: 470 EINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMI 529

Query: 532 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR 591
           QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR
Sbjct: 530 QLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYR 589

Query: 592 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG 651
           APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG
Sbjct: 590 APELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPG 649

Query: 652 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 711
           YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR
Sbjct: 650 YSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 709

Query: 712 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA 771
           ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA
Sbjct: 710 ETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGA 769

Query: 772 SAAGPGFSLKF 782
           SAAGPGFSLKF
Sbjct: 770 SAAGPGFSLKF 780


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 1513 bits (3916), Expect = 0.0
 Identities = 763/782 (97%), Positives = 764/782 (97%), Gaps = 12/782 (1%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDH MEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK 120
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK           K
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK----------WK 110

Query: 121 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 180
           HARVKE  REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK
Sbjct: 111 HARVKE--REHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERK 168

Query: 181 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 240
           MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR
Sbjct: 169 MREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPR 228

Query: 241 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 300
           ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE
Sbjct: 229 ERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEE 288

Query: 301 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 360
           EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP
Sbjct: 289 EEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVP 348

Query: 361 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCR 420
           ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPAL PIELKQELPKYLPALQGCR
Sbjct: 349 ESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCR 408

Query: 421 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 480
           SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ
Sbjct: 409 SVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQ 468

Query: 481 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 540
           HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL
Sbjct: 469 HPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHL 528

Query: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 600
           HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVT WYRAPELLLGAK
Sbjct: 529 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTQWYRAPELLLGAK 588

Query: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660
           EYSTAVDMWSVGCIFGELLTQKPLFPG SEIDQINKVFK+LGTPSEKIWPGYSELP VKK
Sbjct: 589 EYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTPSEKIWPGYSELPVVKK 648

Query: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 720
           MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS
Sbjct: 649 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 708

Query: 721 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 780
           MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL
Sbjct: 709 MFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSL 768

Query: 781 KF 782
           KF
Sbjct: 769 KF 770


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 1494 bits (3869), Expect = 0.0
 Identities = 745/748 (99%), Positives = 746/748 (99%)

Query: 35  LKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
           +  SDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60

Query: 95  EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 154
           EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR
Sbjct: 61  EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 120

Query: 155 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 214
           EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH
Sbjct: 121 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 180

Query: 215 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 274
           HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER
Sbjct: 181 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 240

Query: 275 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 334
           KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ
Sbjct: 241 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 300

Query: 335 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 394
           SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV
Sbjct: 301 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 360

Query: 395 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 454
           PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK
Sbjct: 361 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 420

Query: 455 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 514
           RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM
Sbjct: 421 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 480

Query: 515 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 574
           ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY
Sbjct: 481 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 540

Query: 575 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 634
           GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI
Sbjct: 541 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 600

Query: 635 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 694
           NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF
Sbjct: 601 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 660

Query: 695 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 754
           PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD
Sbjct: 661 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 720

Query: 755 DDLKETGFHLTTTNQGASAAGPGFSLKF 782
           DDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 721 DDLKETGFHLTTTNQGASAAGPGFSLKF 748


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 1463 bits (3787), Expect = 0.0
 Identities = 734/748 (98%), Positives = 735/748 (98%), Gaps = 11/748 (1%)

Query: 35  LKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 94
           +  SDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK
Sbjct: 1   MSQSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRK 60

Query: 95  EKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRR 154
           EKVHHRKDEKRKEK           KHARVKEKEREHERRKRHREEQDKARREWERQKRR
Sbjct: 61  EKVHHRKDEKRKEK-----------KHARVKEKEREHERRKRHREEQDKARREWERQKRR 109

Query: 155 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 214
           EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH
Sbjct: 110 EMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAH 169

Query: 215 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 274
           HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER
Sbjct: 170 HRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSER 229

Query: 275 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 334
           KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ
Sbjct: 230 KTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 289

Query: 335 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 394
           SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV
Sbjct: 290 SAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYV 349

Query: 395 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 454
           PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK
Sbjct: 350 PDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALK 409

Query: 455 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 514
           RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM
Sbjct: 410 RLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLM 469

Query: 515 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 574
           ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY
Sbjct: 470 ETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREY 529

Query: 575 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 634
           GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI
Sbjct: 530 GSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQI 589

Query: 635 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 694
           NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF
Sbjct: 590 NKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYF 649

Query: 695 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 754
           PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD
Sbjct: 650 PGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGD 709

Query: 755 DDLKETGFHLTTTNQGASAAGPGFSLKF 782
           DDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 710 DDLKETGFHLTTTNQGASAAGPGFSLKF 737


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score = 1051 bits (2719), Expect = 0.0
 Identities = 526/526 (100%), Positives = 526/526 (100%)

Query: 257 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 316
           MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE
Sbjct: 1   MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 60

Query: 317 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 376
           EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE
Sbjct: 61  EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE 120

Query: 377 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 436
           EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY
Sbjct: 121 EVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTY 180

Query: 437 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 496
           GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM
Sbjct: 181 GVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNM 240

Query: 497 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 556
           DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL
Sbjct: 241 DKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLL 300

Query: 557 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 616
           LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG
Sbjct: 301 LSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFG 360

Query: 617 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 676
           ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG
Sbjct: 361 ELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFG 420

Query: 677 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 736
           ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR
Sbjct: 421 ALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKR 480

Query: 737 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 782
           GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
Sbjct: 481 GTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF 526



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 30/108 (27%), Positives = 44/108 (40%), Gaps = 10/108 (9%)

Query: 102 DEKRKEKRRHRSHSAEGGKHARVKEKEREHER------RKRHREEQDKARREWERQKRRE 155
           D +RK      S SAE G  +  +E+E E E        +   EE+++   E E     E
Sbjct: 15  DSERKTSSAESS-SAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSE 73

Query: 156 MAREHSRR---ERDRLEQLERKRERERKMREQQKEQREQKERERRAEE 200
            A E S     E +  E  ER+ E    +  + +  R+  E E   EE
Sbjct: 74  EASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEE 121


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  362 bits (928), Expect = e-99
 Identities = 176/327 (53%), Positives = 240/327 (73%), Gaps = 6/327 (1%)

Query: 419 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILK 478
           CRSV+EF+ LNRI EGTYG+VYRA+D +TDEIVALK+++M+KEK+G PI+SLREI  +L+
Sbjct: 33  CRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLR 92

Query: 479 AQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVK 538
            +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M  PF   +VK +++Q+LRG++
Sbjct: 93  LRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQ 152

Query: 539 HLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLG 598
           +LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P+K  TP VVTLWYRAPELLLG
Sbjct: 153 YLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLG 212

Query: 599 AKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAV 658
               +T++DMW+VGCI  ELL  +PL PG SEI QI+ + + LGTPSE IWPG+S+LP V
Sbjct: 213 TTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLV 272

Query: 659 KKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPID 718
            + +  + PYNNL+ +F   LS+ G  L++    Y P +R +A D L+  YF+E PLP +
Sbjct: 273 GQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCE 331

Query: 719 PSMFPTWPAKSEQQRVKRGTSPRPPEG 745
           P + PT+P      R KR  +P   EG
Sbjct: 332 PELMPTFP----HHRNKR-AAPATSEG 353


>gi|169161522 PREDICTED: similar to cell division cycle 2-like 1
           (PITSLRE proteins) [Homo sapiens]
          Length = 155

 Score =  305 bits (782), Expect = 8e-83
 Identities = 154/165 (93%), Positives = 154/165 (93%), Gaps = 10/165 (6%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK 120
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEK HHRKDEKRKEKR          K
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKR----------K 110

Query: 121 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 165
           HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 111 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 155



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 41/155 (26%), Positives = 75/155 (48%), Gaps = 16/155 (10%)

Query: 77  GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHE---- 132
           G+E DS  +K   ++ +++K    ++EK + KR   S   +  + +  + + R+H     
Sbjct: 2   GDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEIT 61

Query: 133 ------RRK-----RHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM 181
                 RR+     R  E+   A +  ++  R+E A      +R    +  R +E+ER+ 
Sbjct: 62  IRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRKHARVKEKERE- 120

Query: 182 REQQKEQREQKERERRAEERRKEREARREVSAHHR 216
            E++K  RE++++ RR  ER+K RE  RE S   R
Sbjct: 121 HERRKRHREEQDKARREWERQKRREMAREHSRRER 155



 Score = 35.4 bits (80), Expect = 0.21
 Identities = 33/168 (19%), Positives = 67/168 (39%), Gaps = 18/168 (10%)

Query: 172 ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHW 231
           E+   + + + E  +E++ +KE+E +AE +R +    R+      + R+   +     H 
Sbjct: 4   EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRD------SKRDSLEEGELRDH- 56

Query: 232 SRSPPRPPRERFELGDGRKPVK-EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS 290
                     R E+     P + E+ ME+R    D   I   ++ +   ++   +     
Sbjct: 57  ----------RMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRK 106

Query: 291 EEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEE 338
           E+ +    +E+E      +   EE+++   E E     E A E S  E
Sbjct: 107 EKRKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 154



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 28/156 (17%), Positives = 62/156 (39%), Gaps = 18/156 (11%)

Query: 168 LEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVK 227
           L++ +R++E+E K   ++ +  + ++ +R + E  + R+ R E++  +   R + S + +
Sbjct: 17  LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDR 76

Query: 228 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 287
                    +PP++           ++EK   R          D +RK     +   E  
Sbjct: 77  GEEDDSLAIKPPQQM---------SRKEKAHHR---------KDEKRKEKRKHARVKEKE 118

Query: 288 SGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEE 323
              E  +   EE+++     E  +  E   E    E
Sbjct: 119 REHERRKRHREEQDKARREWERQKRREMAREHSRRE 154


>gi|237858582 cyclin-dependent kinase 10 isoform d [Homo sapiens]
          Length = 289

 Score =  303 bits (776), Expect = 4e-82
 Identities = 148/288 (51%), Positives = 204/288 (70%), Gaps = 6/288 (2%)

Query: 458 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 517
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 518 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 577
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 578 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 637
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 638 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 697
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239

Query: 698 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 745
           R +A D L+  YF+E PLP +P + PT+P      R KR  +P   EG
Sbjct: 240 RATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 282


>gi|237858580 cyclin-dependent kinase 10 isoform c [Homo sapiens]
          Length = 283

 Score =  290 bits (743), Expect = 3e-78
 Identities = 145/288 (50%), Positives = 200/288 (69%), Gaps = 12/288 (4%)

Query: 458 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 517
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 518 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 577
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 578 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 637
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 638 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 697
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++         
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLF------ 233

Query: 698 RISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEG 745
             +A D L+  YF+E PLP +P + PT+P      R KR  +P   EG
Sbjct: 234 MATAGDCLESSYFKEKPLPCEPELMPTFP----HHRNKR-AAPATSEG 276


>gi|239747195 PREDICTED: similar to PITSLRE protein kinase beta SV2
           [Homo sapiens]
          Length = 153

 Score =  289 bits (740), Expect = 6e-78
 Identities = 150/165 (90%), Positives = 150/165 (90%), Gaps = 12/165 (7%)

Query: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEI 60
           MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDH MEI
Sbjct: 1   MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGK 120
           TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMS KEKVHHRKDEKRKEK           K
Sbjct: 61  TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSWKEKVHHRKDEKRKEK----------WK 110

Query: 121 HARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 165
           HARV  KEREHERRKRHREEQDKARREWERQKRREMAREHSRRER
Sbjct: 111 HARV--KEREHERRKRHREEQDKARREWERQKRREMAREHSRRER 153



 Score = 56.6 bits (135), Expect = 9e-08
 Identities = 40/153 (26%), Positives = 73/153 (47%), Gaps = 14/153 (9%)

Query: 77  GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREH----- 131
           G+E DS  +K   ++ +++K    ++EK + KR   S   +  + +  + + R+H     
Sbjct: 2   GDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEIT 61

Query: 132 --------ERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMRE 183
                   E     R E+D +      Q+     + H R++  R E+ +  R +ER+  E
Sbjct: 62  IRNSPYRREDSMEDRGEEDDSLAIKPPQQMSWKEKVHHRKDEKRKEKWKHARVKERE-HE 120

Query: 184 QQKEQREQKERERRAEERRKEREARREVSAHHR 216
           ++K  RE++++ RR  ER+K RE  RE S   R
Sbjct: 121 RRKRHREEQDKARREWERQKRREMAREHSRRER 153



 Score = 37.7 bits (86), Expect = 0.041
 Identities = 29/123 (23%), Positives = 54/123 (43%), Gaps = 5/123 (4%)

Query: 120 KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERD--RLEQLERKRER 177
           K  R +++E+   +R ++ +++D  R   E  + R+   E + R     R + +E + E 
Sbjct: 20  KKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRGEE 79

Query: 178 ERKMREQQKEQREQKER-ERRAEERRKER--EARREVSAHHRTMREDYSDKVKASHWSRS 234
           +  +  +  +Q   KE+   R +E+RKE+   AR +   H R  R           W R 
Sbjct: 80  DDSLAIKPPQQMSWKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKARREWERQ 139

Query: 235 PPR 237
             R
Sbjct: 140 KRR 142


>gi|237858575 cyclin-dependent kinase 10 isoform b [Homo sapiens]
          Length = 272

 Score =  288 bits (738), Expect = 1e-77
 Identities = 137/258 (53%), Positives = 189/258 (73%), Gaps = 1/258 (0%)

Query: 458 MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETM 517
           M+KEK+G PI+SLREI  +L+ +HPNIV ++E+VVG++++ I++VM Y E DL SL+E M
Sbjct: 1   MDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENM 60

Query: 518 KQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP 577
             PF   +VK +++Q+LRG+++LH N+I+HRDLK SNLL++  G +K  DFGLAR YG P
Sbjct: 61  PTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVP 120

Query: 578 LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKV 637
           +K  TP VVTLWYRAPELLLG    +T++DMW+VGCI  ELL  +PL PG SEI QI+ +
Sbjct: 121 VKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLI 180

Query: 638 FKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGR 697
            + LGTPSE IWPG+S+LP V + +  + PYNNL+ +F   LS+ G  L++    Y P +
Sbjct: 181 VQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKF-PWLSEAGLRLLHFLFMYDPKK 239

Query: 698 RISAEDGLKHEYFRETPL 715
           R +A D L+  YF+E PL
Sbjct: 240 RATAGDCLESSYFKEKPL 257


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  271 bits (694), Expect = 1e-72
 Identities = 136/290 (46%), Positives = 202/290 (69%), Gaps = 5/290 (1%)

Query: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481
           ++ FQ + +I EGTYGVVY+AK+++T ++VALK+++++ E EG P T++REI+ + + +H
Sbjct: 1   MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60

Query: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 540
           PNIV + ++V   N  K+Y+V  ++  DLK  M++     LP   +K+ + QLL+GV   
Sbjct: 61  PNIVRLLDVV--HNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFC 118

Query: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 600
           H + ++HRDLK  NLL++  G +K+ DFGLAR +G PL+ YT  VVTLWYRAPE+LLG+K
Sbjct: 119 HSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSK 178

Query: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660
            Y+TAVD+WS+GCIF E++T+K LFPG SEIDQ+ ++F+ LGTPSE  WPG ++LP  K 
Sbjct: 179 FYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG 238

Query: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 710
            +F +     L +     L  +G DL+ + L Y P +RI+A+  L H YF
Sbjct: 239 -SFPKWTRKGL-EEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYF 286


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  270 bits (691), Expect = 3e-72
 Identities = 133/297 (44%), Positives = 201/297 (67%), Gaps = 5/297 (1%)

Query: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481
           +E FQ + +I EGTYGVVY+A++K T E+VALK+++++ E EG P T++REI+ + +  H
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLMIQLLRGVKHL 540
           PNIV + +++   N  K+Y+V  ++  DLK  M+      +P   +K+ + QLL+G+   
Sbjct: 61  PNIVKLLDVIHTEN--KLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFC 118

Query: 541 HDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAK 600
           H + +LHRDLK  NLL++  G +K+ DFGLAR +G P++ YT  VVTLWYRAPE+LLG K
Sbjct: 119 HSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCK 178

Query: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660
            YSTAVD+WS+GCIF E++T++ LFPG SEIDQ+ ++F+ LGTP E +WPG + +P  K 
Sbjct: 179 YYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP 238

Query: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPI 717
            +F +    +  K     L + G  L+++ L Y P +RISA+  L H +F++   P+
Sbjct: 239 -SFPKWARQDFSKVVPP-LDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPV 293


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  254 bits (649), Expect = 2e-67
 Identities = 124/297 (41%), Positives = 197/297 (66%), Gaps = 14/297 (4%)

Query: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481
           +E++  + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 535
           PNIV+++++++  +  ++Y++  ++  DLK  ++++     PG+      VK+ + Q+L+
Sbjct: 61  PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114

Query: 536 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPEL 595
           G+   H   +LHRDLK  NLL+   G +K+ DFGLAR +G P++ YT  VVTLWYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEV 174

Query: 596 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSEL 655
           LLG+  YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP    L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234

Query: 656 PAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 712
              K  TF +    +L       L + G DL++K L Y P +RIS +  L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  252 bits (644), Expect = 8e-67
 Identities = 122/297 (41%), Positives = 196/297 (65%), Gaps = 14/297 (4%)

Query: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481
           +E++  + +I EGTYGVVY+ + K T ++VA+K++++E E+EG P T++REI+ + + +H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGE------VKTLMIQLLR 535
           PNIV+++++++  +  ++Y++  ++  DLK  ++++     PG+      VK+ + Q+L+
Sbjct: 61  PNIVSLQDVLMQDS--RLYLIFEFLSMDLKKYLDSIP----PGQYMDSSLVKSYLYQILQ 114

Query: 536 GVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPEL 595
           G+   H   +LHRDLK  NLL+   G +K+ DFGLAR +G P++ YT   +TLWYR+PE+
Sbjct: 115 GIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEV 174

Query: 596 LLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSEL 655
           LLG+  YST VD+WS+G IF EL T+KPLF G SEIDQ+ ++F+ LGTP+ ++WP    L
Sbjct: 175 LLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESL 234

Query: 656 PAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 712
              K  TF +    +L       L + G DL++K L Y P +RIS +  L H YF +
Sbjct: 235 QDYKN-TFPKWKPGSLASHV-KNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFND 289


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score =  252 bits (643), Expect = 1e-66
 Identities = 212/769 (27%), Positives = 333/769 (43%), Gaps = 69/769 (8%)

Query: 23   RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDS 82
            RK+++ KA   R K+S +  S      +    D           YRR  S+   G  DDS
Sbjct: 271  RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325

Query: 83   LAIKPPQQM--SRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHER------- 133
                   Q   SRK             +R  RS S    + +    +   +ER       
Sbjct: 326  PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385

Query: 134  -------RKRHREEQDKARREWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQ 185
                   R+         RR  + + R   +  HSR R R RL    R R R   +    
Sbjct: 386  PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLS---RSRSRHSSISPST 442

Query: 186  KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 245
               +     E    ++ +  EA R   A         ++    +  + +   P +   E 
Sbjct: 443  LTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTET 502

Query: 246  GDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGSEEEEEEEE 298
                      K VK+ K+E     S    + + + KT    + +  E+    ++  ++  
Sbjct: 503  SASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAV 562

Query: 299  EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE--------EMSEDEER 350
               +E  ++   EE    +E+ +  T S   +  EQ    V+           + ED+E 
Sbjct: 563  IVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEA 622

Query: 351  ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELK 406
            ++    + V   +      E E+    +    P    L  GD +  SP      + +  K
Sbjct: 623  DSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSK 677

Query: 407  QEL----PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK 457
            +      P+Y    +     G R V++F  +  I EGTYG VY+A+DK T E+VALK+++
Sbjct: 678  RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVR 737

Query: 458  MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHD 509
            ++ EKEGFPIT++REI  + +  H +I+ ++EIV           DK   Y+V  Y++HD
Sbjct: 738  LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797

Query: 510  LKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFG 569
            L  L+E+    F    +K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFG
Sbjct: 798  LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857

Query: 570  LAREYGSP-LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGK 628
            LAR Y S   + YT  V+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F   
Sbjct: 858  LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917

Query: 629  SEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMN 688
             E+ Q+  + +  G+P   +WP   +LP    M   +     LR+ F   +     DL +
Sbjct: 918  QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFD 976

Query: 689  KFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 736
              L   P +R +AE  L+ E+ R+  P  + P   P W    E    KR
Sbjct: 977  YMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 64/336 (19%), Positives = 105/336 (31%), Gaps = 34/336 (10%)

Query: 43  SKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 102
           S   +   GE  + R     R+S  R ++   +    D     +   + S+    H    
Sbjct: 183 SSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQ---RGGSEASKSRSRHSHSG 239

Query: 103 EKRKEKRRHRSHSAEGGKH-----------ARVKEKEREHERRKRHREEQDKARREWERQ 151
           E+R E  +  S S+ GG+            +R     + H  R +  +E   A +E  + 
Sbjct: 240 EERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKA 299

Query: 152 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 211
            R +     + R R  L  L  + +     R  Q  +  +             R   R  
Sbjct: 300 YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359

Query: 212 SAHHRTMREDYS-------------DKVKASHW--SRSPPRPPRERFELGDGRKPVKEEK 256
           S + R     YS                 +S W  SRSP  P   R      R P     
Sbjct: 360 SPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRH 419

Query: 257 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 316
              R        +S S  + SS   S+    S S   E  + ++      +  +E  +  
Sbjct: 420 SRSR----SRHRLSRSRSRHSSISPSTLTLKS-SLAAELNKNKKARAAEAARAAEAAKAA 474

Query: 317 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 352
           E  +  E  + + +AS  S       E S    + N
Sbjct: 475 EATKAAEAAAKAAKASNTSTPTKGNTETSASASQTN 510



 Score = 33.5 bits (75), Expect = 0.78
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 151 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 204
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247

Query: 205 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 249
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305

Query: 250 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 309
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352

Query: 310 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 369
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407

Query: 370 ES 371
           +S
Sbjct: 408 KS 409


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score =  252 bits (643), Expect = 1e-66
 Identities = 212/769 (27%), Positives = 333/769 (43%), Gaps = 69/769 (8%)

Query: 23   RKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDS 82
            RK+++ KA   R K+S +  S      +    D           YRR  S+   G  DDS
Sbjct: 271  RKDRDSKAHRSRTKSSKEPPSAYKEPPKAYREDKT-----EPKAYRRRRSLSPLGGRDDS 325

Query: 83   LAIKPPQQM--SRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHER------- 133
                   Q   SRK             +R  RS S    + +    +   +ER       
Sbjct: 326  PVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPS 385

Query: 134  -------RKRHREEQDKARREWERQKRREMAREHSR-RERDRLEQLERKRERERKMREQQ 185
                   R+         RR  + + R   +  HSR R R RL    R R R   +    
Sbjct: 386  PYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRHSRSRSRHRLS---RSRSRHSSISPST 442

Query: 186  KEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFEL 245
               +     E    ++ +  EA R   A         ++    +  + +   P +   E 
Sbjct: 443  LTLKSSLAAELNKNKKARAAEAARAAEAAKAAEATKAAEAAAKAAKASNTSTPTKGNTET 502

Query: 246  GDGR------KPVKEEKMEERDLLSDLQDISDSERKTSSA-ESSSAESGSGSEEEEEEEE 298
                      K VK+ K+E     S    + + + KT    + +  E+    ++  ++  
Sbjct: 503  SASASQTNHVKDVKKIKIEHAPSPSSGGTLKNDKAKTKPPLQVTKVENNLIVDKATKKAV 562

Query: 299  EEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEE--------EMSEDEER 350
               +E  ++   EE    +E+ +  T S   +  EQ    V+           + ED+E 
Sbjct: 563  IVGKESKSAATKEESVSLKEKTKPLTPSIGAKEKEQHVALVTSTLPPLPLPPMLPEDKEA 622

Query: 351  ENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSP----ALSPIELK 406
            ++    + V   +      E E+    +    P    L  GD +  SP      + +  K
Sbjct: 623  DSLRGNISVKAVK-----KEVEKKLRCLLADLPLPPELPGGDDLSKSPEEKKTATQLHSK 677

Query: 407  QEL----PKYLPALQ-----GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLK 457
            +      P+Y    +     G R V++F  +  I EGTYG VY+A+DK T E+VALK+++
Sbjct: 678  RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVR 737

Query: 458  MEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHD 509
            ++ EKEGFPIT++REI  + +  H +I+ ++EIV           DK   Y+V  Y++HD
Sbjct: 738  LDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHD 797

Query: 510  LKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFG 569
            L  L+E+    F    +K+ M QL+ G+ + H    LHRD+K SN+LL++ G +K+ DFG
Sbjct: 798  LMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFG 857

Query: 570  LAREYGSP-LKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGK 628
            LAR Y S   + YT  V+TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F   
Sbjct: 858  LARLYSSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQAN 917

Query: 629  SEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMN 688
             E+ Q+  + +  G+P   +WP   +LP    M   +     LR+ F   +     DL +
Sbjct: 918  QELAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKKQYRRKLREEF-VFIPAAALDLFD 976

Query: 689  KFLTYFPGRRISAEDGLKHEYFRET-PLPIDPSMFPTWPAKSEQQRVKR 736
              L   P +R +AE  L+ E+ R+  P  + P   P W    E    KR
Sbjct: 977  YMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHELWSKKR 1025



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 64/336 (19%), Positives = 105/336 (31%), Gaps = 34/336 (10%)

Query: 43  SKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 102
           S   +   GE  + R     R+S  R ++   +    D     +   + S+    H    
Sbjct: 183 SSSGTQRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQ---RGGSEASKSRSRHSHSG 239

Query: 103 EKRKEKRRHRSHSAEGGKH-----------ARVKEKEREHERRKRHREEQDKARREWERQ 151
           E+R E  +  S S+ GG+            +R     + H  R +  +E   A +E  + 
Sbjct: 240 EERAEVAKSGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKA 299

Query: 152 KRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREV 211
            R +     + R R  L  L  + +     R  Q  +  +             R   R  
Sbjct: 300 YREDKTEPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGGGSSPYSRRLPRSP 359

Query: 212 SAHHRTMREDYS-------------DKVKASHW--SRSPPRPPRERFELGDGRKPVKEEK 256
           S + R     YS                 +S W  SRSP  P   R      R P     
Sbjct: 360 SPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRSPYSPVLRRSGKSRSRSPYSSRH 419

Query: 257 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 316
              R        +S S  + SS   S+    S S   E  + ++      +  +E  +  
Sbjct: 420 SRSR----SRHRLSRSRSRHSSISPSTLTLKS-SLAAELNKNKKARAAEAARAAEAAKAA 474

Query: 317 EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 352
           E  +  E  + + +AS  S       E S    + N
Sbjct: 475 EATKAAEAAAKAAKASNTSTPTKGNTETSASASQTN 510



 Score = 33.5 bits (75), Expect = 0.78
 Identities = 52/242 (21%), Positives = 82/242 (33%), Gaps = 41/242 (16%)

Query: 151 QKRREMAREHSRRERDRLEQLERKRERERKMREQQK---EQREQKERERRAEERRKE--- 204
           Q+R E +    RR+R       ++R RE + R+ Q+   E  + + R   + E R E   
Sbjct: 188 QRRGEGSERRPRRDRRSSSGRSKERHREHRRRDGQRGGSEASKSRSRHSHSGEERAEVAK 247

Query: 205 ---------REARREVSAHHRTMREDYSDKVKASHW--SRSPP----RPPRERFELGDGR 249
                    R      ++   + R+D   K   S    S+ PP     PP+   E  D  
Sbjct: 248 SGSSSSSGGRRKSASATSSSSSSRKDRDSKAHRSRTKSSKEPPSAYKEPPKAYRE--DKT 305

Query: 250 KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEE 309
           +P    +      L    D   S R + S  S  + S +G              GS+   
Sbjct: 306 EPKAYRRRRSLSPLGGRDDSPVSHRASQSLRSRKSPSPAGG-------------GSSPYS 352

Query: 310 SEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 369
                         + S S  +S +   +VS    S    R + +     P S   R SG
Sbjct: 353 RRLPRSPSPYSRRRSPSYSRHSSYERGGDVSPSPYSSSSWRRSRS-----PYSPVLRRSG 407

Query: 370 ES 371
           +S
Sbjct: 408 KS 409


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  246 bits (627), Expect = 8e-65
 Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)

Query: 370  ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALSPIELKQELPKYLPAL------------ 416
            E E+    +    P    L  GD  P DSP    I   Q+  K  P +            
Sbjct: 657  EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716

Query: 417  --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 474
               G R V++F  +  I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 717  SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776

Query: 475  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 526
             + +  H ++V ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 777  ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836

Query: 527  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 585
            K+ M QL+ G+++ H    LHRD+K SN+LL+++G +K+ DFGLAR Y S   + YT  V
Sbjct: 837  KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896

Query: 586  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 645
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 897  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956

Query: 646  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 705
              +WP   +LP    M   +     LR+ F + +     DL++  LT  P +R +AE  L
Sbjct: 957  PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015

Query: 706  KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 738
            + ++ ++  L  + P   P W                         P+K+ ++    GT 
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075

Query: 739  -------SPRPPEGGLGYSQLGDDD 756
                   SP PP+   G  + G  D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 68/321 (21%), Positives = 117/321 (36%), Gaps = 62/321 (19%)

Query: 31  EIKRLKNSDDRDSKRDSLEEGELRDHRMEI-TIRNSPYRREDSMEDRGEEDDSLAIKPPQ 89
           E  RL +   R   + S + G +      + T+       +D   D     D +A K   
Sbjct: 34  ERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK--- 90

Query: 90  QMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKAR-REW 148
            + R+E      DE+R   R  R H            K R H+    HR  +D  + ++ 
Sbjct: 91  -LDRREN-----DERRGSDRSDRLH------------KHRHHQ----HRRSRDLLKAKQT 128

Query: 149 ERQKRREMAREHSRRERDRLEQLERKRERER----KMREQQKEQREQKERERRAEERRKE 204
           E++K +E++ + S   +DR+    ++   E     K +  +   +E +  +   E+ RKE
Sbjct: 129 EKEKSQEVSSK-SGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKE 187

Query: 205 REARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLS 264
           RE           ++  + D+ K SH  R  P+            K V   K   R   S
Sbjct: 188 RE-----------LKSGHKDRSK-SHRKRETPK----------SYKTVDSPKRRSR---S 222

Query: 265 DLQDISDSERKTSSAESSSAE-----SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE 319
             +  SDS ++  S   +S       S S S      +  ++  GSTS         +E 
Sbjct: 223 PHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEP 282

Query: 320 EEEETGSNSEEASEQSAEEVS 340
              ++ + S     +    VS
Sbjct: 283 SAYQSSTRSPSPYSRRQRSVS 303


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  246 bits (627), Expect = 8e-65
 Identities = 153/445 (34%), Positives = 228/445 (51%), Gaps = 59/445 (13%)

Query: 370  ESEEAEEEVGEGTPQSSALTEGDYVP-DSPALSPIELKQELPKYLPAL------------ 416
            E E+    +    P    L  GD  P DSP    I   Q+  K  P +            
Sbjct: 657  EKEQRTRHLLTDLPLPPELPGGDLSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTE 716

Query: 417  --QGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREIN 474
               G R V++F  +  I EGTYG VY+AKDK T E+VALK+++++ EKEGFPIT++REI 
Sbjct: 717  SDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIK 776

Query: 475  TILKAQHPNIVTVREIVVGSN------MDK--IYIVMNYVEHDLKSLMETMKQPFLPGEV 526
             + +  H ++V ++EIV           DK   Y+V  Y++HDL  L+E+    F    +
Sbjct: 777  ILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHI 836

Query: 527  KTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVV 585
            K+ M QL+ G+++ H    LHRD+K SN+LL+++G +K+ DFGLAR Y S   + YT  V
Sbjct: 837  KSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKV 896

Query: 586  VTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPS 645
            +TLWYR PELLLG + Y+ A+D+WS GCI GEL T+KP+F    E+ Q+  + +  G+P 
Sbjct: 897  ITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPC 956

Query: 646  EKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGL 705
              +WP   +LP    M   +     LR+ F + +     DL++  LT  P +R +AE  L
Sbjct: 957  PAVWPDVIKLPYFNTMKPKKQYRRRLREEF-SFIPSAALDLLDHMLTLDPSKRCTAEQTL 1015

Query: 706  KHEYFRETPL-PIDPSMFPTW-------------------------PAKSEQQRVKRGT- 738
            + ++ ++  L  + P   P W                         P+K+ ++    GT 
Sbjct: 1016 QSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGVVVEEPPPSKTSRKETTSGTS 1075

Query: 739  -------SPRPPEGGLGYSQLGDDD 756
                   SP PP+   G  + G  D
Sbjct: 1076 TEPVKNSSPAPPQPAPGKVESGAGD 1100



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 68/321 (21%), Positives = 117/321 (36%), Gaps = 62/321 (19%)

Query: 31  EIKRLKNSDDRDSKRDSLEEGELRDHRMEI-TIRNSPYRREDSMEDRGEEDDSLAIKPPQ 89
           E  RL +   R   + S + G +      + T+       +D   D     D +A K   
Sbjct: 34  ERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTVIKPLVEYDDISSDSDTFSDDMAFK--- 90

Query: 90  QMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKAR-REW 148
            + R+E      DE+R   R  R H            K R H+    HR  +D  + ++ 
Sbjct: 91  -LDRREN-----DERRGSDRSDRLH------------KHRHHQ----HRRSRDLLKAKQT 128

Query: 149 ERQKRREMAREHSRRERDRLEQLERKRERER----KMREQQKEQREQKERERRAEERRKE 204
           E++K +E++ + S   +DR+    ++   E     K +  +   +E +  +   E+ RKE
Sbjct: 129 EKEKSQEVSSK-SGSMKDRISGSSKRSNEETDDYGKAQVAKSSSKESRSSKLHKEKTRKE 187

Query: 205 REARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLS 264
           RE           ++  + D+ K SH  R  P+            K V   K   R   S
Sbjct: 188 RE-----------LKSGHKDRSK-SHRKRETPK----------SYKTVDSPKRRSR---S 222

Query: 265 DLQDISDSERKTSSAESSSAE-----SGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEE 319
             +  SDS ++  S   +S       S S S      +  ++  GSTS         +E 
Sbjct: 223 PHRKWSDSSKQDDSPSGASYGQDYDLSPSRSHTSSNYDSYKKSPGSTSRRQSVSPPYKEP 282

Query: 320 EEEETGSNSEEASEQSAEEVS 340
              ++ + S     +    VS
Sbjct: 283 SAYQSSTRSPSPYSRRQRSVS 303


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  241 bits (614), Expect = 2e-63
 Identities = 125/295 (42%), Positives = 183/295 (62%), Gaps = 6/295 (2%)

Query: 418 GCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTIL 477
           G   +E +  L ++ EGTY  VY+ + K T+ +VALK +++E E EG P T++RE++ + 
Sbjct: 185 GFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHE-EGAPCTAIREVSLLK 243

Query: 478 KAQHPNIVTVREIVVGSNMDK-IYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRG 536
             +H NIVT+ +IV   + DK + +V  Y++ DLK  M+          VK  + Q+LRG
Sbjct: 244 DLKHANIVTLHDIV---HTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300

Query: 537 VKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELL 596
           + + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  VVTLWYR P++L
Sbjct: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360

Query: 597 LGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELP 656
           LG+ EYST +DMW VGCIF E+ + +PLFPG +  D+++ +F+ LGTPS++ WPG S   
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420

Query: 657 AVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFR 711
             K   F ++    L       L  +G +L+ KFL Y   +R+SAE+ +KH YFR
Sbjct: 421 EFKNYNFPKYKPQPLINH-APRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFR 474


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  240 bits (613), Expect = 3e-63
 Identities = 130/336 (38%), Positives = 198/336 (58%), Gaps = 16/336 (4%)

Query: 423 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKM---EKEKEGFPITSLREINTILKA 479
           + ++ L+ + EG +  VY+A+DK T++IVA+K++K+    + K+G   T+LREI  + + 
Sbjct: 10  KRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL 69

Query: 480 QHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKH 539
            HPNI+ + +     +   I +V +++E DL+ +++       P  +K  M+  L+G+++
Sbjct: 70  SHPNIIGLLDAF--GHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127

Query: 540 LHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGA 599
           LH +WILHRDLK +NLLL   G+LK+ DFGLA+ +GSP +AYT  VVT WYRAPELL GA
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187

Query: 600 KEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVK 659
           + Y   VDMW+VGCI  ELL + P  PG S++DQ+ ++F+ LGTP+E+ WP    LP   
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLP--D 245

Query: 660 KMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDP 719
            +TF   P   L   F A   D   DL+     + P  RI+A   LK +YF   P P   
Sbjct: 246 YVTFKSFPGIPLHHIFSA-AGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPG 304

Query: 720 SMF--PTWPAKSEQQR------VKRGTSPRPPEGGL 747
                P  P ++ +++      +KR  +    +GGL
Sbjct: 305 CQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGL 340


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  240 bits (612), Expect = 4e-63
 Identities = 122/292 (41%), Positives = 186/292 (63%), Gaps = 5/292 (1%)

Query: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481
           +++++ L +I EGTYG V++AK+++T EIVALKR++++ + EG P ++LREI  + + +H
Sbjct: 1   MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60

Query: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 541
            NIV + +++      K+ +V  + + DLK   ++      P  VK+ + QLL+G+   H
Sbjct: 61  KNIVRLHDVLHSDK--KLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCH 118

Query: 542 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKE 601
              +LHRDLK  NLL++  G LK+ DFGLAR +G P++ Y+  VVTLWYR P++L GAK 
Sbjct: 119 SRNVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKL 178

Query: 602 YSTAVDMWSVGCIFGELLTQ-KPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660
           YST++DMWS GCIF EL    +PLFPG    DQ+ ++F+ LGTP+E+ WP  ++LP  K 
Sbjct: 179 YSTSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYK- 237

Query: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRE 712
             +  +P           L+  G DL+   L   P +RISAE+ L+H YF +
Sbjct: 238 -PYPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYFSD 288


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  239 bits (611), Expect = 5e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 285 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 344
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100

Query: 345 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 403
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 101 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 147

Query: 404 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 461
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 148 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 207

Query: 462 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 521
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 208 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 264

Query: 522 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 581
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 265 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 324

Query: 582 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 641
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 325 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 384

Query: 642 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 701
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 385 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 443

Query: 702 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 739
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 444 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  239 bits (611), Expect = 5e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 285 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 344
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 35  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 94

Query: 345 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 403
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 95  SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 141

Query: 404 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 461
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 142 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 201

Query: 462 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 521
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 202 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 258

Query: 522 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 581
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 259 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 318

Query: 582 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 641
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 319 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 378

Query: 642 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 701
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 379 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 437

Query: 702 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 739
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 438 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480


>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
          Length = 346

 Score =  234 bits (598), Expect = 2e-61
 Identities = 127/303 (41%), Positives = 185/303 (61%), Gaps = 3/303 (0%)

Query: 422 VEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQH 481
           ++++  L RI EG +G+V++AK  +T EIVALK++ + + ++GFP  +LREI   L+   
Sbjct: 1   MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKA-LQEME 59

Query: 482 PNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLH 541
            N   V+   V  +     +   ++  DL  ++   ++P    +VK+ +  LL+GV   H
Sbjct: 60  DNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119

Query: 542 DNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSP-LKAYTPVVVTLWYRAPELLLGAK 600
            N I+HRDLK +NLL+S +G LK+ DFGLAR +     + YT  V T WYRAPELL GA+
Sbjct: 120 ANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGAR 179

Query: 601 EYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKK 660
           +Y   VD+WSVGCI GELL   PLFPGK++I+Q+  V + LGTP+ ++WP  +ELP   K
Sbjct: 180 QYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNK 239

Query: 661 MTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPS 720
           ++F E     L +     +S Q  DL+ +FL Y P +RI+A   L H+YF   PLP  PS
Sbjct: 240 ISFKEQVPMPLEEVLPD-VSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPS 298

Query: 721 MFP 723
             P
Sbjct: 299 ELP 301


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  230 bits (587), Expect = 3e-60
 Identities = 122/294 (41%), Positives = 176/294 (59%), Gaps = 5/294 (1%)

Query: 423 EEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHP 482
           + ++ L ++ EG+Y  VY+ K K   ++VALK +++++E EG P T++RE + +   +H 
Sbjct: 115 DSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHA 173

Query: 483 NIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHD 542
           NIV + +I+     + + +V  YV  DL   M+       P  VK  + QLLRG+ ++H 
Sbjct: 174 NIVLLHDII--HTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQ 231

Query: 543 NWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEY 602
            +ILHRDLK  NLL+S  G LK+ DFGLAR    P   Y+  VVTLWYR P++LLG+ EY
Sbjct: 232 RYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEY 291

Query: 603 STAVDMWSVGCIFGELLTQKPLFPGKSEI-DQINKVFKDLGTPSEKIWPGYSELPAVKKM 661
           ST +DMW VGCIF E++     FPG  +I DQ+ ++F  LGTP+E  WPG   LP  K  
Sbjct: 292 STCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPE 351

Query: 662 TFSEHPYNNLRKRFGAL-LSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETP 714
            F+ +   NLR+ +  L   +   DL +K L   P  R+SA+  L HEYF + P
Sbjct: 352 RFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLP 405


>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  229 bits (583), Expect = 1e-59
 Identities = 122/302 (40%), Positives = 192/302 (63%), Gaps = 14/302 (4%)

Query: 419 CRSVEEFQCLNRIEEGTYGVVYRAKDKKTD-EIVALKRLKMEKEKEGFPITSLREINTIL 477
           CR+ ++++C+  I EG YG V++A+D K     VALKR++++  +EG P++++RE+  + 
Sbjct: 7   CRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLR 66

Query: 478 KAQ---HPNIVTVREIVVGSNMD---KIYIVMNYVEHDLKSLMETMKQPFLPGE-VKTLM 530
             +   HPN+V + ++   S  D   K+ +V  +V+ DL + ++ + +P +P E +K +M
Sbjct: 67  HLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMM 126

Query: 531 IQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWY 590
            QLLRG+  LH + ++HRDLK  N+L++ +G +K+ DFGLAR Y   + A T VVVTLWY
Sbjct: 127 FQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQM-ALTSVVVTLWY 185

Query: 591 RAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWP 650
           RAPE+LL +  Y+T VD+WSVGCIF E+  +KPLF G S++DQ+ K+   +G P E+ WP
Sbjct: 186 RAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWP 244

Query: 651 GYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYF 710
               LP     + S  P     ++F   + + G DL+ K LT+ P +RISA   L H YF
Sbjct: 245 RDVALPRQAFHSKSAQPI----EKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYF 300

Query: 711 RE 712
           ++
Sbjct: 301 QD 302


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.309    0.129    0.358 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,120,832
Number of Sequences: 37866
Number of extensions: 1982868
Number of successful extensions: 139363
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 2635
Number of HSP's successfully gapped in prelim test: 1522
Number of HSP's that attempted gapping in prelim test: 18850
Number of HSP's gapped (non-prelim): 34143
length of query: 782
length of database: 18,247,518
effective HSP length: 110
effective length of query: 672
effective length of database: 14,082,258
effective search space: 9463277376
effective search space used: 9463277376
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.