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Search of human proteins with 16306539
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
(799 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens] 1600 0.0
gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens] 1076 0.0
gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens] 965 0.0
gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens] 965 0.0
gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens] 932 0.0
gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens] 926 0.0
gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens] 912 0.0
gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens] 906 0.0
gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens] 896 0.0
gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens] 885 0.0
gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens] 822 0.0
gi|16753221 cadherin 22 precursor [Homo sapiens] 804 0.0
gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens] 803 0.0
gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens] 685 0.0
gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens] 527 e-149
gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens] 434 e-121
gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens] 429 e-120
gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens] 376 e-104
gi|4826669 cadherin 15 preproprotein [Homo sapiens] 363 e-100
gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens] 343 4e-94
gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo sapi... 249 5e-66
gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens] 245 1e-64
gi|4502719 cadherin 13 preproprotein [Homo sapiens] 231 2e-60
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 229 6e-60
gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo sapi... 228 2e-59
gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo sap... 226 5e-59
gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo sapi... 223 7e-58
gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo sap... 216 7e-56
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 207 3e-53
gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo... 207 3e-53
>gi|16306539 cadherin 8, type 2 preproprotein [Homo sapiens]
Length = 799
Score = 1600 bits (4143), Expect = 0.0
Identities = 799/799 (100%), Positives = 799/799 (100%)
Query: 1 MPERLAEMLLDLWTPLIILWITLPPCIYMAPMNQSQVLMSGSPLELNSLGEEQRILNRSK 60
MPERLAEMLLDLWTPLIILWITLPPCIYMAPMNQSQVLMSGSPLELNSLGEEQRILNRSK
Sbjct: 1 MPERLAEMLLDLWTPLIILWITLPPCIYMAPMNQSQVLMSGSPLELNSLGEEQRILNRSK 60
Query: 61 RGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHA 120
RGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHA
Sbjct: 61 RGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHA 120
Query: 121 IKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMS 180
IKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMS
Sbjct: 121 IKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMS 180
Query: 181 ILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEY 240
ILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEY
Sbjct: 181 ILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEY 240
Query: 241 LVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKA 300
LVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKA
Sbjct: 241 LVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKA 300
Query: 301 NDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANV 360
NDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANV
Sbjct: 301 NDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANV 360
Query: 361 HIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI 420
HIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI
Sbjct: 361 HIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI 420
Query: 421 TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRV 480
TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRV
Sbjct: 421 TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRV 480
Query: 481 PVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMV 540
PVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMV
Sbjct: 481 PVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMV 540
Query: 541 NNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCS 600
NNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCS
Sbjct: 541 NNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCS 600
Query: 601 NDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDV 660
NDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDV
Sbjct: 601 NDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDV 660
Query: 661 RENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVD 720
RENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVD
Sbjct: 661 RENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVD 720
Query: 721 VDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWG 780
VDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWG
Sbjct: 721 VDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWG 780
Query: 781 PRFKRLGELYSVGESDKET 799
PRFKRLGELYSVGESDKET
Sbjct: 781 PRFKRLGELYSVGESDKET 799
>gi|16306532 cadherin 11, type 2 preproprotein [Homo sapiens]
Length = 796
Score = 1076 bits (2782), Expect = 0.0
Identities = 519/745 (69%), Positives = 621/745 (83%), Gaps = 4/745 (0%)
Query: 50 GEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIF 109
G+E ++L RSKRGWVWNQ FV+EE++GP+P+LVGRLH+D+D G IKYILSG+GAGTIF
Sbjct: 42 GKEGQVLQRSKRGWVWNQFFVIEEYTGPDPVLVGRLHSDIDSGDGNIKYILSGEGAGTIF 101
Query: 110 QINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLN 169
I+D +G+IHA K LDREE+A+YTL AQAVD +T++PLEPPSEFI+KVQDINDN PEFL+
Sbjct: 102 VIDDKSGNIHATKTLDREERAQYTLMAQAVDRDTNRPLEPPSEFIVKVQDINDNPPEFLH 161
Query: 170 GPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTAL 229
YHA VPE S +GTSV VTA+DADDP YGNSAKLVYSILEGQPYFS+E +T II+TAL
Sbjct: 162 ETYHANVPERSNVGTSVIQVTASDADDPTYGNSAKLVYSILEGQPYFSVEAQTGIIRTAL 221
Query: 230 PNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDV 289
PNMDREAKEEY VVIQAKDMGGH GGLSGTT +T+TLTDVNDNPPKF QS+Y SV E
Sbjct: 222 PNMDREAKEEYHVVIQAKDMGGHMGGLSGTTKVTITLTDVNDNPPKFPQSVYQMSVSEAA 281
Query: 290 VLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKK 349
V G +GRVKA D DIGEN +Y+I+DGDG FEIT+D + Q+G+I+L+KP+DFETK+
Sbjct: 282 VPGEEVGRVKAKDPDIGENGLVTYNIVDGDGMESFEITTDYETQEGVIKLKKPVDFETKR 341
Query: 350 SYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSV 409
+Y+LKVEAANVHIDP+F GPFKDT TVKI VEDADEPP+F +P+Y+ EV ENAA +V
Sbjct: 342 AYSLKVEAANVHIDPKFISNGPFKDTVTVKISVEDADEPPMFLAPSYIHEVQENAAAGTV 401
Query: 410 IGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIAT 469
+G+V A+DPD +SPIR+SIDRHTDL+R F IN +DG I PLDRE + W NIT+ A
Sbjct: 402 VGRVHAKDPDAANSPIRYSIDRHTDLDRFFTINPEDGFIKTTKPLDREETAWLNITVFAA 461
Query: 470 EIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENG--KP--GQVIQTVSAMDKDDP 525
EI N Q ++VPVAI+VLDVNDNAP+FA+ YE F+CE+ KP Q I T+SA DKDD
Sbjct: 462 EIHNRHQEAKVPVAIRVLDVNDNAPKFAAPYEGFICESDQTKPLSNQPIVTISADDKDDT 521
Query: 526 KNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPP 585
NG F++SL PE+++NPNFT++ N DN+ + A+ GF+RQKQ++YLLPI+ISD G PP
Sbjct: 522 ANGPRFIFSLPPEIIHNPNFTVRDNRDNTAGVYARRGGFSRQKQDLYLLPIVISDGGIPP 581
Query: 586 LSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLR 645
+SST+TLTI+VCGC +G + SCN EAY+L GLS GALIAILACI++LLVIVVLFVTLR
Sbjct: 582 MSSTNTLTIKVCGCDVNGALLSCNAEAYILNAGLSTGALIAILACIVILLVIVVLFVTLR 641
Query: 646 RHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQ 705
R K EPLI+ ++EDVRENII YDDEGGGEEDTEAFDIATLQNPDGINGF+PRKDIKP+ Q
Sbjct: 642 RQKKEPLIVFEEEDVRENIITYDDEGGGEEDTEAFDIATLQNPDGINGFIPRKDIKPEYQ 701
Query: 706 FMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLEST 765
+MPR GL P PN VDVD+FIN R+ EADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLES
Sbjct: 702 YMPRPGLRPAPNSVDVDDFINTRIQEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESA 761
Query: 766 TSDSDQNFDYLSDWGPRFKRLGELY 790
T+DSD ++DYL +WGPRFK+L +LY
Sbjct: 762 TTDSDLDYDYLQNWGPRFKKLADLY 786
>gi|16306487 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 965 bits (2495), Expect = 0.0
Identities = 463/738 (62%), Positives = 581/738 (78%)
Query: 57 NRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTG 116
+R+KR WVWNQ FVLEE+ G +P+ VG+LH+D+D G IKYILSG+GA +IF I++ TG
Sbjct: 43 SRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTG 102
Query: 117 DIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATV 176
DIHA KRLDREE+A YTL AQA+D T+KP+EP SEF+IK+QDINDN P+FL+GPY A V
Sbjct: 103 DIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGV 162
Query: 177 PEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREA 236
PEMS +GTSV VTATDADDP YGNSA++VYSIL+GQPYFS+EP+T +IKTALPNMDREA
Sbjct: 163 PEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREA 222
Query: 237 KEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIG 296
K++YL+VIQAKDM G +GGLSGTT++TVTLTDVNDNPP+F + Y ++VPE + + + +
Sbjct: 223 KDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVA 282
Query: 297 RVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVE 356
R+KA D DIG NA+ Y I+DGDG +F+I+ D + Q+GII ++K LDFE K SYTL++E
Sbjct: 283 RIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIE 342
Query: 357 AANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTAR 416
AAN DPRF GPF DT TVKI+VED DEPPVFSSP Y +EV E + ++IG V A
Sbjct: 343 AANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAH 402
Query: 417 DPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQ 476
DPD ++SP+R+SIDR+TDLER FNI+A+ G IT A LDRE + HNIT++A E +N SQ
Sbjct: 403 DPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQ 462
Query: 477 ISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLL 536
+ R VAI +LD+NDNAPEFA +YE +CEN +PGQVIQ +SA+DKD+P NGH F +SL
Sbjct: 463 VGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLT 522
Query: 537 PEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
+ NN NF++K N+DN+ SIL + NGF RQ+Q VY LPI I DSG+P LSST+TLTIRV
Sbjct: 523 TDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRV 582
Query: 597 CGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKD 656
C C DGV Q+CN EAYVLP GLS GALIAILAC++ LLV+++L VT+RR K EPLI +
Sbjct: 583 CDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDE 642
Query: 657 DEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVP 716
+ D+RENI+RYDDEGGGEEDTEAFD+A L+N + I R+D+ P++QF+ R +P
Sbjct: 643 ERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIP 702
Query: 717 NGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYL 776
+ V EFI RL EAD DP APPYDS+Q Y +EG GSVA SLSSL+S +S+SDQN+DYL
Sbjct: 703 DNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYL 762
Query: 777 SDWGPRFKRLGELYSVGE 794
SDWGPRFKRL ++Y G+
Sbjct: 763 SDWGPRFKRLADMYGTGQ 780
>gi|16306489 cadherin 7, type 2 preproprotein [Homo sapiens]
Length = 785
Score = 965 bits (2495), Expect = 0.0
Identities = 463/738 (62%), Positives = 581/738 (78%)
Query: 57 NRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTG 116
+R+KR WVWNQ FVLEE+ G +P+ VG+LH+D+D G IKYILSG+GA +IF I++ TG
Sbjct: 43 SRTKRSWVWNQFFVLEEYMGSDPLYVGKLHSDVDKGDGSIKYILSGEGASSIFIIDENTG 102
Query: 117 DIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATV 176
DIHA KRLDREE+A YTL AQA+D T+KP+EP SEF+IK+QDINDN P+FL+GPY A V
Sbjct: 103 DIHATKRLDREEQAYYTLRAQALDRLTNKPVEPESEFVIKIQDINDNEPKFLDGPYTAGV 162
Query: 177 PEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREA 236
PEMS +GTSV VTATDADDP YGNSA++VYSIL+GQPYFS+EP+T +IKTALPNMDREA
Sbjct: 163 PEMSPVGTSVVQVTATDADDPTYGNSARVVYSILQGQPYFSVEPKTGVIKTALPNMDREA 222
Query: 237 KEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIG 296
K++YL+VIQAKDM G +GGLSGTT++TVTLTDVNDNPP+F + Y ++VPE + + + +
Sbjct: 223 KDQYLLVIQAKDMVGQNGGLSGTTSVTVTLTDVNDNPPRFPRRSYQYNVPESLPVASVVA 282
Query: 297 RVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVE 356
R+KA D DIG NA+ Y I+DGDG +F+I+ D + Q+GII ++K LDFE K SYTL++E
Sbjct: 283 RIKAADADIGANAEMEYKIVDGDGLGIFKISVDKETQEGIITIQKELDFEAKTSYTLRIE 342
Query: 357 AANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTAR 416
AAN DPRF GPF DT TVKI+VED DEPPVFSSP Y +EV E + ++IG V A
Sbjct: 343 AANKDADPRFLSLGPFSDTTTVKIIVEDVDEPPVFSSPLYPMEVSEATQVGNIIGTVAAH 402
Query: 417 DPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQ 476
DPD ++SP+R+SIDR+TDLER FNI+A+ G IT A LDRE + HNIT++A E +N SQ
Sbjct: 403 DPDSSNSPVRYSIDRNTDLERYFNIDANSGVITTAKSLDRETNAIHNITVLAMESQNPSQ 462
Query: 477 ISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLL 536
+ R VAI +LD+NDNAPEFA +YE +CEN +PGQVIQ +SA+DKD+P NGH F +SL
Sbjct: 463 VGRGYVAITILDINDNAPEFAMDYETTVCENAQPGQVIQKISAVDKDEPSNGHQFYFSLT 522
Query: 537 PEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
+ NN NF++K N+DN+ SIL + NGF RQ+Q VY LPI I DSG+P LSST+TLTIRV
Sbjct: 523 TDATNNHNFSLKDNKDNTASILTRRNGFRRQEQSVYYLPIFIVDSGSPSLSSTNTLTIRV 582
Query: 597 CGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKD 656
C C DGV Q+CN EAYVLP GLS GALIAILAC++ LLV+++L VT+RR K EPLI +
Sbjct: 583 CDCDADGVAQTCNAEAYVLPAGLSTGALIAILACVLTLLVLILLIVTMRRRKKEPLIFDE 642
Query: 657 DEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVP 716
+ D+RENI+RYDDEGGGEEDTEAFD+A L+N + I R+D+ P++QF+ R +P
Sbjct: 643 ERDIRENIVRYDDEGGGEEDTEAFDMAALRNLNVIRDTKTRRDVTPEIQFLSRPAFKSIP 702
Query: 717 NGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYL 776
+ V EFI RL EAD DP APPYDS+Q Y +EG GSVA SLSSL+S +S+SDQN+DYL
Sbjct: 703 DNVIFREFIWERLKEADVDPGAPPYDSLQTYAFEGNGSVAESLSSLDSISSNSDQNYDYL 762
Query: 777 SDWGPRFKRLGELYSVGE 794
SDWGPRFKRL ++Y G+
Sbjct: 763 SDWGPRFKRLADMYGTGQ 780
>gi|16306530 cadherin 10, type 2 preproprotein [Homo sapiens]
Length = 788
Score = 932 bits (2410), Expect = 0.0
Identities = 461/790 (58%), Positives = 586/790 (74%), Gaps = 16/790 (2%)
Query: 16 LIILWITLP----PCIYM--APMNQSQVLMSGSPLELNSLGEEQRILNRSKRGWVWNQMF 69
L + W+ LP P I P+ Q ++L S P + +IL+R KRGW+WNQ F
Sbjct: 9 LFLFWVCLPHFCSPEIMFRRTPVPQQRILSSRVPRS------DGKILHRQKRGWMWNQFF 62
Query: 70 VLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEK 129
+LEE++G + VG+LH+D D G +KYILSGDGAGT+F I++ TGDIHA +R+DREEK
Sbjct: 63 LLEEYTGSDYQYVGKLHSDQDKGDGSLKYILSGDGAGTLFIIDEKTGDIHATRRIDREEK 122
Query: 130 AEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNV 189
A YTL AQA++ T +P+EP SEF+IK+ DINDN P F Y A+VPEMS++GTSV V
Sbjct: 123 AFYTLRAQAINRRTLRPVEPESEFVIKIHDINDNEPTFPEEIYTASVPEMSVVGTSVVQV 182
Query: 190 TATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDM 249
TATDADDP YGNSA+++YSIL+GQPYFS+EPET II+TALPNM+RE +E+Y VVIQAKDM
Sbjct: 183 TATDADDPSYGNSARVIYSILQGQPYFSVEPETGIIRTALPNMNRENREQYQVVIQAKDM 242
Query: 250 GGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENA 309
GG GGLSGTTT+ +TLTDVNDNPP+F Q+ H V E +GTAIG VKA D D G+NA
Sbjct: 243 GGQMGGLSGTTTVNITLTDVNDNPPRFPQNTIHLRVLESSPVGTAIGSVKATDADTGKNA 302
Query: 310 QSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGR 369
+ Y IIDGDGT +F+I ++ Q+GII ++KPLD+E+++ YTLKVEA N H+DPRF
Sbjct: 303 EVEYRIIDGDGTDMFDIVTEKDTQEGIITVKKPLDYESRRLYTLKVEAENTHVDPRFYYL 362
Query: 370 GPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSI 429
GPFKDT VKI +ED DEPPVFS +YL EVHE+ + ++IG V ARDPD SSPIRFS+
Sbjct: 363 GPFKDTTIVKISIEDVDEPPVFSRSSYLFEVHEDIEVGTIIGTVMARDPDSISSPIRFSL 422
Query: 430 DRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDV 489
DRHTDL+R FNI++ +G + + PLDRELS WHN+T+IA EI N + +RV V +++LDV
Sbjct: 423 DRHTDLDRIFNIHSGNGSLYTSKPLDRELSQWHNLTVIAAEINNPKETTRVAVFVRILDV 482
Query: 490 NDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKK 549
NDNAP+FA Y+ F+CEN +PGQ+IQT+SA+DKDDP G F +SL NPNFT++
Sbjct: 483 NDNAPQFAVFYDTFVCENARPGQLIQTISAVDKDDPLGGQKFFFSL---AAVNPNFTVQD 539
Query: 550 NEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCN 609
NEDN+ IL + NGFNR + YLLP++ISD+ P SST TLTIRVC C + G +QSC+
Sbjct: 540 NEDNTARILTRKNGFNRHEISTYLLPVVISDNDYPIQSSTGTLTIRVCACDSQGNMQSCS 599
Query: 610 VEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDD 669
EA +LP GLS GALIAIL CII+LLVIVVLF L+R + + +I ED+R+NI+ Y+D
Sbjct: 600 AEALLLPAGLSTGALIAILLCIIILLVIVVLFAALKRQRKKEPLILSKEDIRDNIVSYND 659
Query: 670 EGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRL 729
EGGGEEDT+AFDI TL+NP I R+DI P+ F+PR+ P+ DV +FIN RL
Sbjct: 660 EGGGEEDTQAFDIGTLRNPAAIEEKKLRRDIIPETLFIPRR-TPTAPDNTDVRDFINERL 718
Query: 730 HEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGEL 789
E D DPTAPPYDS+ Y YEG S+A SLSSLES T++ DQN+DYL +WGPRF +L E+
Sbjct: 719 KEHDLDPTAPPYDSLATYAYEGNDSIAESLSSLESGTTEGDQNYDYLREWGPRFNKLAEM 778
Query: 790 YSVGESDKET 799
Y GESDK++
Sbjct: 779 YGGGESDKDS 788
>gi|4826673 cadherin 6, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 926 bits (2392), Expect = 0.0
Identities = 460/788 (58%), Positives = 582/788 (73%), Gaps = 9/788 (1%)
Query: 16 LIILWITLPPCIYMAPMNQSQVLMSGSPLELNSL---GEEQRILNRSKRGWVWNQMFVLE 72
L++ W+ P P+++ SG P + +L G + LNRSKR W+WNQ F+LE
Sbjct: 8 LLLFWVGQPYPTLSTPLSKRT---SGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLE 64
Query: 73 EFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEY 132
E++G + VG+LH+D D G +KYILSGDGAG +F IN+ TGDI A KRLDREEK Y
Sbjct: 65 EYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVY 124
Query: 133 TLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTAT 192
L AQA++ T +P+EP SEFIIK+ DINDN P F Y ATVPEMS +GT V VTAT
Sbjct: 125 ILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTAT 184
Query: 193 DADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGH 252
DADDP YGNSAK+VYSIL+GQPYFS+E ET IIKTAL NMDRE +E+Y VVIQAKDMGG
Sbjct: 185 DADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQ 244
Query: 253 SGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSS 312
GGLSGTTT+ +TLTDVNDNPP+F QS Y F PE GT IGR+KA+D D+GENA+
Sbjct: 245 MGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIE 304
Query: 313 YDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPF 372
Y I DG+G +F++ +D + Q+GII ++K LDFE KK YTLKVEA+N +++PRF GPF
Sbjct: 305 YSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPF 364
Query: 373 KDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRH 432
KD+ATV+IVVED DEPPVFS Y+L++ E+A +N+ IG VTA+DPD +P+++S+DRH
Sbjct: 365 KDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRH 424
Query: 433 TDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDN 492
TD++R FNI++ +G I + LDRE +WHNIT+IATEI N Q SRVP+ IKVLDVNDN
Sbjct: 425 TDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDN 484
Query: 493 APEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNED 552
APEFA YE F+CE K Q+IQT+ A+DKDDP +GH F +SL PE + NFTI+ N+D
Sbjct: 485 APEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKD 544
Query: 553 NSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEA 612
N+ IL + NG+NR + YLLP++ISD+ P SST T+T+RVC C + G +QSC+ EA
Sbjct: 545 NTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEA 604
Query: 613 YVLPIGLSMGALIAILACIILLLVIVVLFVTLRR-HKNEPLIIKDDEDVRENIIRYDDEG 671
+ P GLS GAL+AIL CI++LLV VVLF LRR K EPLII ED+R+NI+ Y+DEG
Sbjct: 605 LIHPTGLSTGALVAILLCIVILLVTVVLFAALRRQRKKEPLII-SKEDIRDNIVSYNDEG 663
Query: 672 GGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHE 731
GGEEDT+AFDI TL+NP+ I R+DI P+ F+PR+ + DV +FIN RL E
Sbjct: 664 GGEEDTQAFDIGTLRNPEAIEDNKLRRDIVPEALFLPRR-TPTARDNTDVRDFINQRLKE 722
Query: 732 ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYS 791
D DPTAPPYDS+ Y YEG GSVA SLSSLES T+D+DQ++DYLSDWGPRFK+L ++Y
Sbjct: 723 NDTDPTAPPYDSLATYAYEGTGSVADSLSSLESVTTDADQDYDYLSDWGPRFKKLADMYG 782
Query: 792 VGESDKET 799
+SDK++
Sbjct: 783 GVDSDKDS 790
>gi|16306537 cadherin 20, type 2 preproprotein [Homo sapiens]
Length = 801
Score = 912 bits (2357), Expect = 0.0
Identities = 452/783 (57%), Positives = 586/783 (74%), Gaps = 8/783 (1%)
Query: 20 WITLPPCIYM-APMNQSQVLMSGSPL---ELNSL-GEEQRILNRSKRGWVWNQMFVLEEF 74
W+ L +Y M+ + ++S +P EL +L ++ + R+KR WVWNQ FVLEE+
Sbjct: 13 WLGLGMSLYFWGLMDLTTTVLSDTPTPQGELEALLSDKPQSHQRTKRSWVWNQFFVLEEY 72
Query: 75 SGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTL 134
+G +P+ VG+LH+D+D G IKYILSG+GAG +F I+D TGDIHAI+RLDREE+A+YTL
Sbjct: 73 TGTDPLYVGKLHSDMDRGDGSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTL 132
Query: 135 TAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDA 194
AQA+D T +P+EP SEFIIK+QDINDN P+FL+GPY ATVPEMS +GTSV VTATDA
Sbjct: 133 RAQALDRRTGRPMEPESEFIIKIQDINDNEPKFLDGPYVATVPEMSPVGTSVIQVTATDA 192
Query: 195 DDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSG 254
DDP YGNSA++VYSIL+GQPYFS++ +T +I+TAL NMDREAKE Y V+IQAKDMGG G
Sbjct: 193 DDPTYGNSARVVYSILQGQPYFSVDSKTGVIRTALMNMDREAKEYYEVIIQAKDMGGQLG 252
Query: 255 GLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYD 314
GL+GTTT+ +TL+DVNDNPP+F Q Y SV E + + +GRV A D D G NA+ Y
Sbjct: 253 GLAGTTTVNITLSDVNDNPPRFPQKHYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYT 312
Query: 315 IIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKD 374
I+DGDG F+I++D Q GII ++KPL FE+KKSYTLKVE AN H++ RF GPF+D
Sbjct: 313 IVDGDGADAFDISTDPNFQVGIITVKKPLSFESKKSYTLKVEGANPHLEMRFLNLGPFQD 372
Query: 375 TATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTD 434
T TV I VED DEPPVF Y +EV E+ A+ + I ++A+DPD+T++ IR+SIDR +D
Sbjct: 373 TTTVHISVEDVDEPPVFEPGFYFVEVPEDVAIGTTIQIISAKDPDVTNNSIRYSIDRSSD 432
Query: 435 LERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAP 494
R F ++ G + A PLDRE WHNIT++A E+ N SQ+ VPV IKVLDVNDNAP
Sbjct: 433 PGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDNAP 492
Query: 495 EFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNS 554
EF YEAF+CEN K GQ+IQTVSA+D+DDP+NG +F YSL PE NNPNFTI+ N+DN+
Sbjct: 493 EFPRFYEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANNPNFTIRDNQDNT 552
Query: 555 LSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYV 614
IL + +GF +Q+Q V+ LPI+I+DSG P LSST TLTI+VC C +DG V SC+ EAY+
Sbjct: 553 ARILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVCSCDDDGHVMSCSPEAYM 612
Query: 615 LPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGE 674
LP+ LS GALIAILACI +LLV+V+L +++RRH+ +P II D+E++ ENI+RYDDEGGGE
Sbjct: 613 LPVSLSRGALIAILACIFVLLVLVLLILSMRRHRKQPYIIDDEENIHENIVRYDDEGGGE 672
Query: 675 EDTEAFDIATLQNP-DGINGFLP--RKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHE 731
EDTEAFDIA + NP + G P R+D+ P+++ + R V ++ +L+E
Sbjct: 673 EDTEAFDIAAMWNPREAQAGAAPKTRQDMLPEIESLSRYVPQTCAVNSTVHSYVLAKLYE 732
Query: 732 ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYS 791
AD D APP+DS+Q Y +EG GSVAGSLSSL+S TSDS+Q+FD+L+DWGPRF++L ELY
Sbjct: 733 ADMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYG 792
Query: 792 VGE 794
E
Sbjct: 793 ASE 795
>gi|4826671 cadherin 18, type 2 preproprotein [Homo sapiens]
Length = 790
Score = 906 bits (2341), Expect = 0.0
Identities = 442/748 (59%), Positives = 559/748 (74%), Gaps = 1/748 (0%)
Query: 52 EQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQI 111
E + +R KRGWVWNQ FVLEE GP+P VG+LH++ D G +KYIL+G+GAGTIF I
Sbjct: 44 ETEVHHRPKRGWVWNQFFVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFII 103
Query: 112 NDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGP 171
+D TGDIH+ K LDRE+K Y L AQA+D T+KPLEP SEFIIKVQDINDNAP+F +GP
Sbjct: 104 DDTTGDIHSTKSLDREQKTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGP 163
Query: 172 YHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPN 231
Y TVPEMS +GTSV VTATDADDP YGNSA++VYSIL+GQPYFS++P+T +I+TAL N
Sbjct: 164 YIVTVPEMSDMGTSVLQVTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHN 223
Query: 232 MDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVL 291
MDREA+E Y VVIQAKDM G GGLSG+TT+ +TLTDVNDNPP+F Q Y VPE +
Sbjct: 224 MDREAREHYSVVIQAKDMAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQV 283
Query: 292 GTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSY 351
G+A+G++KAND D G NA +Y II+GDG +F I++D + ++GI+ L+KPL++E KKSY
Sbjct: 284 GSAVGKIKANDADTGSNADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSY 343
Query: 352 TLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIG 411
TL +E AN H+D RFS GPFKD +KI+V D DEPP+FS P+YL+EV+ENA + +V+G
Sbjct: 344 TLNIEGANTHLDFRFSHLGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVG 403
Query: 412 QVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEI 471
V A+DPD T+S +R+ I+ + + +R FNI+A+ G I LDRE + W+NIT+ A+EI
Sbjct: 404 TVLAQDPDSTNSLVRYFINYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEI 463
Query: 472 RNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYF 531
N +S V V I+VLDVNDN PE A EY+ +CEN KPGQVI T+SA DKDD NG F
Sbjct: 464 DNPDLLSHVTVGIRVLDVNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRF 523
Query: 532 LYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTST 591
+ L + NPNFT+K NEDN+ SIL + F+R Q+VY LPI+ISD G P LSS+ST
Sbjct: 524 NFFLDERLPVNPNFTLKDNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSST 583
Query: 592 LTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEP 651
LTIRVC C DG V++C+ EA++ GLS GALIAIL C+++LL IVVLF+TLRR K EP
Sbjct: 584 LTIRVCACERDGRVRTCHAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEP 643
Query: 652 LIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQG 711
LII +EDVREN++ YDDEGGGEEDTEAFDI L+NP R+DI+P+++ PR
Sbjct: 644 LII-SEEDVRENVVTYDDEGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQ 702
Query: 712 LAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQ 771
+ +DV EFI RL EAD DP+ PPYDS+Q Y YEG+ S AGS+SSL+S T+ SDQ
Sbjct: 703 TSSTLESIDVQEFIKQRLAEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQ 762
Query: 772 NFDYLSDWGPRFKRLGELYSVGESDKET 799
++ YL DWGP FK+L ELY ES++ T
Sbjct: 763 DYHYLGDWGPEFKKLAELYGEIESERTT 790
>gi|90193626 cadherin 9, type 2 preproprotein [Homo sapiens]
Length = 789
Score = 896 bits (2316), Expect = 0.0
Identities = 434/749 (57%), Positives = 563/749 (75%), Gaps = 3/749 (0%)
Query: 51 EEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQ 110
++ ++L R+KRGW+WNQ F+LEE++G + VG+LHTD D G +KYIL+GDGAG++F
Sbjct: 43 DDGKMLRRTKRGWMWNQFFLLEEYTGTDTQYVGKLHTDQDKGDGNLKYILTGDGAGSLFV 102
Query: 111 INDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNG 170
I++ TGDIHA K+LDREEK+ Y L A+A+D +T + +EP SEFIIK+ DINDN P+F
Sbjct: 103 IDENTGDIHAAKKLDREEKSLYILRAKAIDRKTGRQVEPESEFIIKIHDINDNEPKFTKD 162
Query: 171 PYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALP 230
Y A+VPEMS +GTSV VTATDADD YGNSAK+VYSIL+GQPYFS++PE+ IIKTALP
Sbjct: 163 LYTASVPEMSGVGTSVIQVTATDADDANYGNSAKVVYSILQGQPYFSVDPESGIIKTALP 222
Query: 231 NMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVV 290
+M RE +E+Y VVIQAKDMGG GGLSGTTT+ +TLTDVN+NPP+F QS Y F+ PE V
Sbjct: 223 DMSRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNNNPPRFPQSTYQFNSPESVP 282
Query: 291 LGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKS 350
LGT +GR+KAND D+GENA+ Y I +GDG +F++ +D Q+GII +++ LDFE +
Sbjct: 283 LGTHLGRIKANDPDVGENAEMEYSIAEGDGADMFDVITDKDTQEGIITVKQNLDFENQML 342
Query: 351 YTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVI 410
YTL+V+A+N H DPRF GPFKDTA VKI VED DEPPVF+ +YL+EV E+ S+I
Sbjct: 343 YTLRVDASNTHPDPRFLHLGPFKDTAVVKISVEDIDEPPVFTKVSYLIEVDEDVKEGSII 402
Query: 411 GQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATE 470
GQVTA DPD ++ I++S+DRHTD++R F I++++G I LDRE S WHNIT+ ATE
Sbjct: 403 GQVTAYDPDARNNLIKYSVDRHTDMDRIFGIHSENGSIFTLKALDRESSPWHNITVTATE 462
Query: 471 IRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHY 530
I N Q S +PV I++LD+ND+APEFA YE F+CEN KPGQ+IQTVS MDKDDP GH
Sbjct: 463 INNPKQSSHIPVFIRILDINDHAPEFAMYYETFVCENAKPGQLIQTVSVMDKDDPPRGHK 522
Query: 531 FLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTS 590
F + +PE NPNFTI N+DN+ I+ + +G++R K YLLPI+I D+ P SST
Sbjct: 523 FFFEPVPEFTLNPNFTIVDNKDNTAGIMTRKDGYSRNKMSTYLLPILIFDNDYPIQSSTG 582
Query: 591 TLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRH-KN 649
TLTIRVC C N G +QSC EA +L GLS GAL+AIL C+++LL++VVLF L+R K
Sbjct: 583 TLTIRVCACDNQGNMQSCTAEALILSAGLSTGALVAILLCVLILLILVVLFAALKRQRKK 642
Query: 650 EPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPR 709
EPLII D DVR+NI+ Y+DEGGGEEDT+AFDI TL+NP+ R+D+ P+ F R
Sbjct: 643 EPLIISKD-DVRDNIVTYNDEGGGEEDTQAFDIGTLRNPEAREDSKLRRDVMPETIFQIR 701
Query: 710 QGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDS 769
+ P+ +DV +FI+ RL E D DP+APPYDS+ Y YEG S+A SLSSLES T+D
Sbjct: 702 R-TVPLWENIDVQDFIHRRLKENDADPSAPPYDSLATYAYEGNDSIADSLSSLESLTADC 760
Query: 770 DQNFDYLSDWGPRFKRLGELYSVGESDKE 798
+Q++DYLSDWGPRFK+L ++Y +SD++
Sbjct: 761 NQDYDYLSDWGPRFKKLADMYGGDDSDRD 789
>gi|16445393 cadherin 12, type 2 preproprotein [Homo sapiens]
Length = 794
Score = 885 bits (2287), Expect = 0.0
Identities = 437/780 (56%), Positives = 567/780 (72%), Gaps = 2/780 (0%)
Query: 17 IILWITLPPCIYMAPMNQSQVLMSGSPLE-LNSLGEEQRILNRSKRGWVWNQMFVLEEFS 75
++LW+ + Q Q ++ P E + L ++ R KRGWVWNQ FVLEE+
Sbjct: 9 LLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQFFVLEEYV 68
Query: 76 GPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLT 135
G EP VG+LH+DLD G +KY LSGDGAGT+F I++ TGDIHAI+ LDREEK YTL
Sbjct: 69 GSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLR 128
Query: 136 AQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDAD 195
AQAVD ET KPLEP SEFIIKVQDINDN P+FL+GPY ATVPEMS +G V V ATDAD
Sbjct: 129 AQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVLQVKATDAD 188
Query: 196 DPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGG 255
DP YGNSA++VYSIL+GQPYFSI+P+T +I+TALPNMDRE KE+Y V+IQAKDMGG GG
Sbjct: 189 DPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAKDMGGQLGG 248
Query: 256 LSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDI 315
L+GTT + +TLTDVNDNPP+F +S++H VPE +G+AIGR++A D D G+NA+ Y+I
Sbjct: 249 LAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNI 308
Query: 316 IDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDT 375
+ GDG LF+I +D Q+G+I+L+KPLDFETKK+YT KVEA+N+H+D RF GPFKDT
Sbjct: 309 VPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFHSAGPFKDT 368
Query: 376 ATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDL 435
ATVKI V D DEPPVFS P Y +EV+E+ + ++IG VTA+D D+ SS +R+ ID +D
Sbjct: 369 ATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRYFIDWKSDG 428
Query: 436 ERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPE 495
+ F I+ ++G I LDRE + +N +IIA+++ N S+V + I VLDVN+ PE
Sbjct: 429 DSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEFPPE 488
Query: 496 FASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSL 555
+ YE +CEN KPGQ+IQ VSA D+D G F + L PE PNFT++ +N+
Sbjct: 489 ISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTVRDFRNNTA 548
Query: 556 SILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVL 615
I + NG++R++QE+Y LP++I DS P SST+T+TIRVC C +DG + SCNVEA L
Sbjct: 549 GIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILSCNVEAIFL 608
Query: 616 PIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEE 675
P+GLS GALIAIL CI++LL IVVL+V LRR K + ++ ED+R+N+I YDDEGGGEE
Sbjct: 609 PVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHYDDEGGGEE 668
Query: 676 DTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADND 735
DT+AFDI L+NP I R+DIKPD +PRQ P+ + D+ +FI+ RL E D D
Sbjct: 669 DTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQ-RPPMEDNTDIRDFIHQRLQENDVD 727
Query: 736 PTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGES 795
PTAPPYDS+ Y YEG GSVA SLSS++S T+++DQ++DYL+DWGPRFK L +++ ES
Sbjct: 728 PTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFGEEES 787
>gi|32880203 cadherin-like 24 isoform 2 [Homo sapiens]
Length = 781
Score = 822 bits (2122), Expect = 0.0
Identities = 409/742 (55%), Positives = 534/742 (71%), Gaps = 6/742 (0%)
Query: 56 LNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVT 115
L R++R WVWNQ FV+EE++GPEP+L+G+LH+D+D G + KY+L+G+GAGT+F I++ T
Sbjct: 39 LLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEAT 98
Query: 116 GDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHAT 175
G+IH K LDREEKA+Y L AQAVD +++PLEPPSEFIIKVQDINDN P F GPYHAT
Sbjct: 99 GNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHAT 158
Query: 176 VPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDRE 235
VPEMS +GTSV VTA DADDP YGNSAKLVY++L+G P+FS++P+T +++TA+PNMDRE
Sbjct: 159 VPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRE 218
Query: 236 AKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAI 295
+EE+LVVIQAKDMGGH GGLSG+TT+TVTL+DVNDNPPKF QSLY FSV E GT +
Sbjct: 219 TQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLV 278
Query: 296 GRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKV 355
GR++A D D+G+NA +Y I+DG+G+ F I++D Q +DG++ +RKPLDFE+++SY+ +V
Sbjct: 279 GRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRV 338
Query: 356 EAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTA 415
EA N IDP + RGPFKD A+V++ V+DA EPP F+ Y L V EN A +++GQ++A
Sbjct: 339 EATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISA 398
Query: 416 RDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHS 475
D D +SPIR+SI H+D ER F+I ++G I A PLDRE WHN+T++ATE+ + +
Sbjct: 399 ADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNLTVLATELDSSA 458
Query: 476 QISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSL 535
Q SRV VAI+ LD NDNAP+ A Y+ F+C++ PGQ+IQ + A+D+D+ N + S
Sbjct: 459 QASRVQVAIQTLDENDNAPQLAEPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSH--VSF 516
Query: 536 LPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIR 595
+ + NFT++ N D S S+L + YL+PI + D G P LSST+T+T+
Sbjct: 517 QGPLGPDANFTVQDNRDGSASLLLPSRP-APPRHAPYLVPIELWDWGQPALSSTATVTVS 575
Query: 596 VCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIK 655
VC C DG V SC EA++ GLS GAL+AI+ C+ LL +VVLFV LRR K E L++
Sbjct: 576 VCRCQPDGSVASCWPEAHLSAAGLSTGALLAIITCVGALLALVVLFVALRRQKQEALMVL 635
Query: 656 DDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPV 715
++EDVRENII YDDEGGGEEDTEAFDI LQNPDG P + D+ R P
Sbjct: 636 EEEDVRENIITYDDEGGGEEDTEAFDITALQNPDGAAPPAPGPPARRDVLPRARVSRQPR 695
Query: 716 PNG-VDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSL--ESTTSDSDQN 772
P G DV + + +RL EAD DP PPYDS+Q+YGYEGRGS GSLSSL S +
Sbjct: 696 PPGPADVAQLLALRLREADEDPGVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGAPGP 755
Query: 773 FDYLSDWGPRFKRLGELYSVGE 794
+ L DWGP F+ L ELY E
Sbjct: 756 AEPLDDWGPLFRTLAELYGAKE 777
>gi|16753221 cadherin 22 precursor [Homo sapiens]
Length = 828
Score = 804 bits (2076), Expect = 0.0
Identities = 395/812 (48%), Positives = 564/812 (69%), Gaps = 31/812 (3%)
Query: 14 TPLIILWITLPPCIYMAPMNQSQVLMSGSPLELNSLGEEQRILN--RSKRGWVWNQMFVL 71
+P ++L + LPP P ++ +G+P + L R KRGWVWNQ FV+
Sbjct: 17 SPALLLLLLLPP----PPTLLGRLWAAGTPSPSAPGARQDGALGAGRVKRGWVWNQFFVV 72
Query: 72 EEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAE 131
EE++G EP+ VG++H+D D G IKY +SG+GAGTIF I+++TGDIHA++RLDRE+K
Sbjct: 73 EEYTGTEPLYVGKIHSDSDEGDGAIKYTISGEGAGTIFLIDELTGDIHAMERLDREQKTF 132
Query: 132 YTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTA 191
YTL AQA D T++ LEP SEFIIKVQDIND+ P FL+GPY +V E+S GTSV V A
Sbjct: 133 YTLRAQARDRATNRLLEPESEFIIKVQDINDSEPRFLHGPYIGSVAELSPTGTSVMQVMA 192
Query: 192 TDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGG 251
+DADDP YG+SA+LVYS+L+G+ +F+++P+T +I+TA+P++DRE++E Y VVIQA DM G
Sbjct: 193 SDADDPTYGSSARLVYSVLDGEHHFTVDPKTGVIRTAVPDLDRESQERYEVVIQATDMAG 252
Query: 252 HSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQS 311
GGLSG+TT+T+ +TDVNDNPP+F Q +Y FS+ E +GTA+GRVKA D D+GEN
Sbjct: 253 QLGGLSGSTTVTIVVTDVNDNPPRFPQKMYQFSIQESAPIGTAVGRVKAEDSDVGENTDM 312
Query: 312 SYDIID--GDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGR 369
+Y + D G +F++T+D+ Q+ II ++K LDFE++ +T+ +EA N +DPRF+
Sbjct: 313 TYHLKDESSSGGDVFKVTTDSDTQEAIIVVQKRLDFESQPVHTVILEALNKFVDPRFADL 372
Query: 370 GPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSI 429
G F+D A V++ V D DEPP F P+ LLEV E+A + S++G VTARDPD + P+R++I
Sbjct: 373 GTFRDQAIVRVAVTDVDEPPEFRPPSGLLEVQEDAQVGSLVGVVTARDPDAANRPVRYAI 432
Query: 430 DRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDV 489
DR +DL++ F+I+AD G I LDRE + WHNIT++A E NH+Q+SR + I++LDV
Sbjct: 433 DRESDLDQIFDIDADTGAIVTGKGLDRETAGWHNITVLAMEADNHAQLSRASLRIRILDV 492
Query: 490 NDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKK 549
NDN PE A+ YEA +CE+ KPGQ+IQT+S +D+D+P+ GH F + L+PE +NP+F++
Sbjct: 493 NDNPPELATPYEAAVCEDAKPGQLIQTISVVDRDEPQGGHRFYFRLVPEAPSNPHFSLLD 552
Query: 550 NEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCN 609
+DN+ ++ +H GFNRQ+Q+V+ LPI++ DSG P LSST TLTIR+CGC + G +QSCN
Sbjct: 553 IQDNTAAVHTQHVGFNRQEQDVFFLPILVVDSGPPTLSSTGTLTIRICGCDSSGTIQSCN 612
Query: 610 VEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDD 669
A+V+ LS GALIA+L C+++L+V+V+L +TLRRH L +DED+R+N+I+Y+D
Sbjct: 613 TTAFVMAASLSPGALIALLVCVLILVVLVLLILTLRRHHKSHLSSDEDEDMRDNVIKYND 672
Query: 670 EGGGEEDTEAFDIATLQN-----------------------PDGINGFLPRKDIKPDLQF 706
EGGGE+DTEA+D++ L++ G G P+ + +
Sbjct: 673 EGGGEQDTEAYDMSALRSLYDFGELKGGDGGGSAGGGAGGGSGGGAGSPPQAHLPSERHS 732
Query: 707 MPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTT 766
+P+ +P P+ +FI+ ++ AD D + PPYD+ Q Y +EG S A SLSSL S +
Sbjct: 733 LPQGPPSPEPDFSVFRDFISRKVALADGDLSVPPYDAFQTYAFEGADSPAASLSSLHSGS 792
Query: 767 SDSDQNFDYLSDWGPRFKRLGELYSVGESDKE 798
S S+Q+F YLS WGPRF+ L LY+ D E
Sbjct: 793 SGSEQDFAYLSSWGPRFRPLAALYAGHRGDDE 824
>gi|32880206 cadherin-like 24 isoform 1 [Homo sapiens]
Length = 819
Score = 803 bits (2073), Expect = 0.0
Identities = 409/780 (52%), Positives = 534/780 (68%), Gaps = 44/780 (5%)
Query: 56 LNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVT 115
L R++R WVWNQ FV+EE++GPEP+L+G+LH+D+D G + KY+L+G+GAGT+F I++ T
Sbjct: 39 LLRTRRSWVWNQFFVIEEYAGPEPVLIGKLHSDVDRGEGRTKYLLTGEGAGTVFVIDEAT 98
Query: 116 GDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHAT 175
G+IH K LDREEKA+Y L AQAVD +++PLEPPSEFIIKVQDINDN P F GPYHAT
Sbjct: 99 GNIHVTKSLDREEKAQYVLLAQAVDRASNRPLEPPSEFIIKVQDINDNPPIFPLGPYHAT 158
Query: 176 VPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDRE 235
VPEMS +GTSV VTA DADDP YGNSAKLVY++L+G P+FS++P+T +++TA+PNMDRE
Sbjct: 159 VPEMSNVGTSVIQVTAHDADDPSYGNSAKLVYTVLDGLPFFSVDPQTGVVRTAIPNMDRE 218
Query: 236 AKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAI 295
+EE+LVVIQAKDMGGH GGLSG+TT+TVTL+DVNDNPPKF QSLY FSV E GT +
Sbjct: 219 TQEEFLVVIQAKDMGGHMGGLSGSTTVTVTLSDVNDNPPKFPQSLYQFSVVETAGPGTLV 278
Query: 296 GRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKV 355
GR++A D D+G+NA +Y I+DG+G+ F I++D Q +DG++ +RKPLDFE+++SY+ +V
Sbjct: 279 GRLRAQDPDLGDNALMAYSILDGEGSEAFSISTDLQGRDGLLTVRKPLDFESQRSYSFRV 338
Query: 356 EAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTA 415
EA N IDP + RGPFKD A+V++ V+DA EPP F+ Y L V EN A +++GQ++A
Sbjct: 339 EATNTLIDPAYLRRGPFKDVASVRVAVQDAPEPPAFTQAAYHLTVPENKAPGTLVGQISA 398
Query: 416 RDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEI---- 471
D D +SPIR+SI H+D ER F+I ++G I A PLDRE WHN+T++ATE+
Sbjct: 399 ADLDSPASPIRYSILPHSDPERCFSIQPEEGTIHTAAPLDREARAWHNLTVLATELGWSW 458
Query: 472 ----------------------------------RNHSQISRVPVAIKVLDVNDNAPEFA 497
+ +Q SRV VAI+ LD NDNAP+ A
Sbjct: 459 GPERGWVPLLVAEWSAPAAPPQRSPVGSAVGIPQDSSAQASRVQVAIQTLDENDNAPQLA 518
Query: 498 SEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSI 557
Y+ F+C++ PGQ+IQ + A+D+D+ N + S + + NFT++ N D S S+
Sbjct: 519 EPYDTFVCDSAAPGQLIQVIRALDRDEVGNSSH--VSFQGPLGPDANFTVQDNRDGSASL 576
Query: 558 LAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPI 617
L + YL+PI + D G P LSST+T+T+ VC C DG V SC EA++
Sbjct: 577 LLPSRP-APPRHAPYLVPIELWDWGQPALSSTATVTVSVCRCQPDGSVASCWPEAHLSAA 635
Query: 618 GLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDT 677
GLS GAL+AI+ C+ LL +VVLFV LRR K E L++ ++EDVRENII YDDEGGGEEDT
Sbjct: 636 GLSTGALLAIITCVGALLALVVLFVALRRQKQEALMVLEEEDVRENIITYDDEGGGEEDT 695
Query: 678 EAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNG-VDVDEFINVRLHEADNDP 736
EAFDI LQNPDG P + D+ R P P G DV + + +RL EAD DP
Sbjct: 696 EAFDITALQNPDGAAPPAPGPPARRDVLPRARVSRQPRPPGPADVAQLLALRLREADEDP 755
Query: 737 TAPPYDSIQIYGYEGRGSVAGSLSSL--ESTTSDSDQNFDYLSDWGPRFKRLGELYSVGE 794
PPYDS+Q+YGYEGRGS GSLSSL S + + L DWGP F+ L ELY E
Sbjct: 756 GVPPYDSVQVYGYEGRGSSCGSLSSLGSGSEAGGAPGPAEPLDDWGPLFRTLAELYGAKE 815
>gi|12656655 cadherin 19, type 2 preproprotein [Homo sapiens]
Length = 772
Score = 685 bits (1767), Expect = 0.0
Identities = 353/733 (48%), Positives = 491/733 (66%), Gaps = 8/733 (1%)
Query: 58 RSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGD 117
R KRGWVWNQ FV EE + +G+L +DLD G+ +Y L G GAG+ F I++ TGD
Sbjct: 40 RVKRGWVWNQFFVPEEMNTTSHH-IGQLRSDLDNGNNSFQYKLLGAGAGSTFIIDERTGD 98
Query: 118 IHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVP 177
I+AI++LDREE++ Y L AQ +D T + +EP SEF+IKV DINDN P+FL+ PY A VP
Sbjct: 99 IYAIQKLDREERSLYILRAQVIDIATGRAVEPESEFVIKVSDINDNEPKFLDEPYEAIVP 158
Query: 178 EMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAK 237
EMS GT V VTA+DADDP GN+A+L+YS+L+GQPYFS+EP T +I+ + MDRE +
Sbjct: 159 EMSPEGTLVIQVTASDADDPSSGNNARLLYSLLQGQPYFSVEPTTGVIRIS-SKMDRELQ 217
Query: 238 EEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGR 297
+EY V+IQAKDM G G LSGTT++ + L+DVNDN P F +SLY +V E GT+IG
Sbjct: 218 DEYWVIIQAKDMIGQPGALSGTTSVLIKLSDVNDNKPIFKESLYRLTVSESAPTGTSIGT 277
Query: 298 VKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEA 357
+ A D DIGENA+ Y I + D + F+I ++ + Q+GI+ L+K +DFE + Y ++ +
Sbjct: 278 IMAYDNDIGENAEMDYSI-EEDDSQTFDIITNHETQEGIVILKKKVDFEHQNHYGIRAKV 336
Query: 358 ANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARD 417
N H+ + T +KI VED DEPP+F P Y+ EV E S +G V+A D
Sbjct: 337 KNHHVPEQLMKYHTEASTTFIKIQVEDVDEPPLFLLPYYVFEVFEETPQGSFVGVVSATD 396
Query: 418 PDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQI 477
PD SPIR+SI R + FNIN D+G IT + LDRE+S W+N++I ATE N QI
Sbjct: 397 PDNRKSPIRYSITR----SKVFNIN-DNGTITTSNSLDREISAWYNLSITATEKYNIEQI 451
Query: 478 SRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLP 537
S +P+ ++VL++ND+APEF+ YE ++CEN GQVIQT+SA+D+D+ H+F ++L
Sbjct: 452 SSIPLYVQVLNINDHAPEFSQYYETYVCENAGSGQVIQTISAVDRDESIEEHHFYFNLSV 511
Query: 538 EMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVC 597
E NN +FTI N+DN+ IL GFN Q++ V+ + I+I+D+G P L+ST+TLTI VC
Sbjct: 512 EDTNNSSFTIIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVC 571
Query: 598 GCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDD 657
C + G Q+C + VL +G +IAIL CI+++ + L + L++ + + L +
Sbjct: 572 DCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFGFIFLTLGLKQRRKQILFPEKS 631
Query: 658 EDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPN 717
ED RENI +YDDEGGGEEDTEAFDIA L++ + RK +++ + RQ L P+
Sbjct: 632 EDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPD 691
Query: 718 GVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLS 777
+FI +L EA+ DP APP+DS+Q Y +EG GS+AGSLSSLES SD D+++DYL+
Sbjct: 692 SAIFRKFILEKLEEANTDPCAPPFDSLQTYAFEGTGSLAGSLSSLESAVSDQDESYDYLN 751
Query: 778 DWGPRFKRLGELY 790
+ GPRFKRL ++
Sbjct: 752 ELGPRFKRLACMF 764
>gi|166362713 cadherin 5, type 2 preproprotein [Homo sapiens]
Length = 784
Score = 527 bits (1357), Expect = e-149
Identities = 308/744 (41%), Positives = 438/744 (58%), Gaps = 24/744 (3%)
Query: 58 RSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGD 117
R KR W+WNQM + EE + P VG++ + + K KY+L G+ G +F+++ TGD
Sbjct: 44 RQKRDWIWNQMHIDEEKNTSLPHHVGKIKSSVS--RKNAKYLLKGEYVGKVFRVDAETGD 101
Query: 118 IHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVP 177
+ AI+RLDRE +EY LTA VD +T + LE PS F IKV D+NDN P F + ++A+VP
Sbjct: 102 VFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNASVP 161
Query: 178 EMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAK 237
E S +GTSV +VTA DADDP G+ A ++Y IL+G+ YF+I+ II T ++DRE +
Sbjct: 162 ESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRII-TITKSLDREKQ 220
Query: 238 EEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGR 297
Y +V++A+D G G SGT T+ VTL D+NDN P F Q+ Y F VPED +GT++G
Sbjct: 221 ARYEIVVEARDAQGLRGD-SGTATVLVTLQDINDNFPFFTQTKYTFVVPEDTRVGTSVGS 279
Query: 298 VKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEA 357
+ D D +N + Y I+ GD F I ++ +GII+ KPLD+E + Y+ VEA
Sbjct: 280 LFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEA 339
Query: 358 ANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARD 417
+ ID R+ P + A V I + D DEPP+F P Y ++ EN +IG V A D
Sbjct: 340 TDPTIDLRYMS-PPAGNRAQVIINITDVDEPPIFQQPFYHFQLKENQK-KPLIGTVLAMD 397
Query: 418 PDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRN---- 473
PD I +SI R +D + F + G I LDRE+ W+N+T+ A E+ +
Sbjct: 398 PDAARHSIGYSIRRTSDKGQFFRV-TKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTP 456
Query: 474 HSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLY 533
+ S V V I+VLD NDNAPEFA Y+ +CEN GQ++ +SA+DKD F +
Sbjct: 457 TGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKF 516
Query: 534 SLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLT 593
L E NFT+ N DN+ +I K+ F+R+ +V+ LP++ISD+G P + TSTLT
Sbjct: 517 ILNTE----NNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLT 572
Query: 594 IRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVL-FVTLRRHKNEPL 652
+ VC C+ G C E +G+S+ A++AIL CI+ + VI +L F+ R K
Sbjct: 573 VAVCKCNEQGEFTFC--EDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARA 630
Query: 653 IIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQN--PDGINGFLPRKDIKPDL----QF 706
K ++ E ++ YD+EGGGE DT ++D++ L + G P D +P L Q
Sbjct: 631 HGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQK 690
Query: 707 MPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTT 766
PR ++ I V+ EAD+D PPYD++ IYGYEG S+A SLSSL + +
Sbjct: 691 PPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDS 750
Query: 767 SDSDQNFDYLSDWGPRFKRLGELY 790
SDSD ++D+L+DWGPRFK L ELY
Sbjct: 751 SDSDVDYDFLNDWGPRFKMLAELY 774
>gi|14589893 cadherin 4, type 1 preproprotein [Homo sapiens]
Length = 916
Score = 434 bits (1115), Expect = e-121
Identities = 301/778 (38%), Positives = 433/778 (55%), Gaps = 62/778 (7%)
Query: 56 LNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGT----IFQI 111
L R KR WV + V E GP P + R+ +D D I+Y ++G GA +F I
Sbjct: 164 LRRRKRDWVIPPINVPENSRGPFPQQLVRIRSDKD-NDIPIRYSITGVGADQPPMEVFSI 222
Query: 112 NDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGP 171
+ ++G ++ + +DREE A Y L A AVD +K +E P + I V D+NDN PEF+N
Sbjct: 223 DSMSGRMYVTRPMDREEHASYHLRAHAVDMNGNK-VENPIDLYIYVIDMNDNRPEFINQV 281
Query: 172 YHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPY------FSIEPETAII 225
Y+ +V E S GT V VTA DADD N + Y I+ P F+I ET I
Sbjct: 282 YNGSVDEGSKPGTYVMTVTANDADDSTTANGM-VRYRIVTQTPQSPSQNMFTINSETGDI 340
Query: 226 KTALPNMDREAKEEYLVVIQAKDMGGHSG-GLSGTTTLTVTLTDVNDNPPKFAQSLYHFS 284
T +DRE ++Y V++QA DM G+ GLS T T +T+TDVNDNPP+F S +
Sbjct: 341 VTVAAGLDREKVQQYTVIVQATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGE 400
Query: 285 VPEDVVLGTAIG-RVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPL 343
VPE+ V V DQ N + Y II GD + F + +D +G++ + K +
Sbjct: 401 VPENRVETVVANLTVMDRDQPHSPNWNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAV 460
Query: 344 DFETKKSYTLKVEAANVHIDPRFSG-RGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHE 402
D+E +++ L V +N P SG + F+ TA V I + D +E P F S L+ + E
Sbjct: 461 DYELNRAFMLTVMVSNQA--PLASGIQMSFQSTAGVTISIMDINEAPYFPSNHKLIRLEE 518
Query: 403 NAALNSVIGQVTARDPD-ITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVW 461
+V+ +A DPD +R+S + +D +INA +G+IT A LDRE
Sbjct: 519 GVPPGTVLTTFSAVDPDRFMQQAVRYS--KLSDPASWLHINATNGQITTAAVLDRESLYT 576
Query: 462 HNITIIATEIRNHSQISRVP----VAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTV 517
N AT + + I + I ++D+NDNAPE + EA +CE KP +
Sbjct: 577 KNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPK-EAQICE--KPNLNAINI 633
Query: 518 SAMDKD-DPKNGHY-FLYSLLPEMVNNPNFTIKKNEDN----SLSILAKHNGFNRQKQEV 571
+A D D DP G Y F +P V N+TI + + SL IL G +
Sbjct: 634 TAADADVDPNIGPYVFELPFVPAAVRK-NWTITRLNGDYAQLSLRILYLEAG-------M 685
Query: 572 YLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACI 631
Y +PII++DSGNPPLS+TS + ++VC C ++G C V GL GA++AIL CI
Sbjct: 686 YDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNG---DCTTIGAVAAAGLGTGAIVAILICI 742
Query: 632 ILLLVIVVLFVT-LRRHKNE----PLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQ 686
++LL +V+LFV ++R + E L+I ++DVR+NI++YD+EGGGEED + +D++ LQ
Sbjct: 743 LILLTMVLLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQD-YDLSQLQ 801
Query: 687 NPDGINGFLPRK-------DIKPDLQFMPRQGLAP-VPNGVDVDEFINVRLHEADNDPTA 738
P+ + G +P K D +P + P+ + P VP+ D+ +FIN L ADNDPTA
Sbjct: 802 QPEAM-GHVPSKAPGVRRVDERP-VGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTA 859
Query: 739 PPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESD 796
PPYDS+ ++ YEG GS AGS+SSL S++S DQ++DYL+DWGPRFK+L ++Y GE D
Sbjct: 860 PPYDSLLVFDYEGSGSTAGSVSSLNSSSS-GDQDYDYLNDWGPRFKKLADMYGGGEED 916
>gi|14589889 cadherin 2, type 1 preproprotein [Homo sapiens]
Length = 906
Score = 429 bits (1103), Expect = e-120
Identities = 288/773 (37%), Positives = 430/773 (55%), Gaps = 55/773 (7%)
Query: 56 LNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGT----IFQI 111
L R KR WV + + E GP P + R+ +D D + ++Y ++G GA IF I
Sbjct: 154 LQRQKRDWVIPPINLPENSRGPFPQELVRIRSDRDK-NLSLRYSVTGPGADQPPTGIFII 212
Query: 112 NDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGP 171
N ++G + K LDRE+ A + L A AVD ++ +E P + +I V D+NDN PEFL+
Sbjct: 213 NPISGQLSVTKPLDREQIARFHLRAHAVDINGNQ-VENPIDIVINVIDMNDNRPEFLHQV 271
Query: 172 YHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP------YFSIEPETAII 225
++ TVPE S GT V VTA DADDP N L Y I+ P F+I ET I
Sbjct: 272 WNGTVPEGSKPGTYVMTVTAIDADDPNALNGM-LRYRIVSQAPSTPSPNMFTINNETGDI 330
Query: 226 KTALPNMDREAKEEYLVVIQAKDMGGH-SGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFS 284
T +DRE ++Y ++IQA DM G+ + GLS T T +T+TDVNDNPP+F ++
Sbjct: 331 ITVAAGLDREKVQQYTLIIQATDMEGNPTYGLSNTATAVITVTDVNDNPPEFTAMTFYGE 390
Query: 285 VPEDVVLGTAIGRVKANDQDIGENA--QSSYDIIDGDGTALFEITSDAQAQDGIIRLRKP 342
VPE+ V + + D+D + Y I GD T F I +D + DG++ + KP
Sbjct: 391 VPENRV-DIIVANLTVTDKDQPHTPAWNAVYRISGGDPTGRFAIQTDPNSNDGLVTVVKP 449
Query: 343 LDFETKKSYTLKVEAANVHIDPRFSG-RGPFKDTATVKIVVEDADEPPVFSSPTYLLEVH 401
+DFET + + L V A N P G + P + TATV + V D +E P F+ ++
Sbjct: 450 IDFETNRMFVLTVAAENQV--PLAKGIQHPPQSTATVSVTVIDVNENPYFAPNPKIIRQE 507
Query: 402 ENAALNSVIGQVTARDPD-ITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDREL-- 458
E +++ TA+DPD IR++ + +D I+ +G+IT LDRE
Sbjct: 508 EGLHAGTMLTTFTAQDPDRYMQQNIRYT--KLSDPANWLKIDPVNGQITTIAVLDRESPN 565
Query: 459 --SVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQT 516
+ +N T +A++ + I +LD+NDNAP+ + EA CE P +
Sbjct: 566 VKNNIYNATFLASDNGIPPMSGTGTLQIYLLDINDNAPQVLPQ-EAETCETPDPNSI--N 622
Query: 517 VSAMDKDDPKNGHYFLYSL-LPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLP 575
++A+D D N F + L L + N+TI + + + K + +Y +P
Sbjct: 623 ITALDYDIDPNAGPFAFDLPLSPVTIKRNWTITRLNGDFAQLNLK---IKFLEAGIYEVP 679
Query: 576 IIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLL 635
III+DSGNPP S+ S L ++VC C ++G C ++ GL GA+IAIL CII+LL
Sbjct: 680 IIITDSGNPPKSNISILRVKVCQCDSNG---DCTDVDRIVGAGLGTGAIIAILLCIIILL 736
Query: 636 VIVVLFVTLRRHKNEP-----LIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDG 690
++V++FV + +++ L+I ++DVR+NI++YD+EGGGEED + +D++ LQ PD
Sbjct: 737 ILVLMFVVWMKRRDKERQAKQLLIDPEDDVRDNILKYDEEGGGEEDQD-YDLSQLQQPDT 795
Query: 691 INGF------LPRKDIKP---DLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPY 741
+ + R D +P + Q+ P + AP P D+ +FIN L ADNDPTAPPY
Sbjct: 796 VEPDAIKPVGIRRMDERPIHAEPQY-PVRSAAPHPG--DIGDFINEGLKAADNDPTAPPY 852
Query: 742 DSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGE 794
DS+ ++ YEG GS AGSLSSL S++S +Q++DYL+DWGPRFK+L ++Y G+
Sbjct: 853 DSLLVFDYEGSGSTAGSLSSLNSSSSGGEQDYDYLNDWGPRFKKLADMYGGGD 905
>gi|4757960 cadherin 1, type 1 preproprotein [Homo sapiens]
Length = 882
Score = 376 bits (965), Expect = e-104
Identities = 279/788 (35%), Positives = 393/788 (49%), Gaps = 61/788 (7%)
Query: 36 QVLMSGSPLELNSLGEEQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKK 95
Q +SG EL + L R KR WV + E GP P + ++ ++ D K
Sbjct: 129 QASVSGIQAELLTFPNSSPGLRRQKRDWVIPPISCPENEKGPFPKNLVQIKSNKDKEGK- 187
Query: 96 IKYILSGDGAGT----IFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPS 151
+ Y ++G GA T +F I TG + + LDRE A YTL + AV +E P
Sbjct: 188 VFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVS-SNGNAVEDPM 246
Query: 152 EFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILE 211
E +I V D NDN PEF + +V E ++ GTSV VTATDADD V +A + Y+IL
Sbjct: 247 EILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILS 306
Query: 212 GQP------YFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVT 265
P F+I T +I +DRE+ Y +V+QA D+ G GLS T T +T
Sbjct: 307 QDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGE--GLSTTATAVIT 364
Query: 266 LTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENA--QSSYDIIDGDGTAL 323
+TD NDNPP F + Y VPE+ I +K D D ++ Y I++ DG
Sbjct: 365 VTDTNDNPPIFNPTTYKGQVPENEA-NVVITTLKVTDADAPNTPAWEAVYTILNDDG-GQ 422
Query: 324 FEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFK-----DTATV 378
F +T++ DGI++ K LDFE K+ Y L V NV PF+ TATV
Sbjct: 423 FVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVV---------PFEVSLTTSTATV 473
Query: 379 KIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPD-ITSSPIRFSIDRHTDLER 437
+ V D +E P+F P +EV E+ + I TA++PD I + I R D
Sbjct: 474 TVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWR--DTAN 531
Query: 438 QFNINADDGKITLATPLDRE-----LSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDN 492
IN D G I+ LDRE + + IIAT+ + + + + DVNDN
Sbjct: 532 WLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDN 591
Query: 493 APEFASEYEAFLCE-NGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNE 551
AP F CE N KP Q ++ +D D P N F L + N+TI+ N+
Sbjct: 592 AP-IPEPRTIFFCERNPKP----QVINIIDADLPPNTSPFTAELTHGA--SANWTIQYND 644
Query: 552 DNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVE 611
SI+ K + EV I + N +TL + VC C +G C +
Sbjct: 645 PTQESIILKP----KMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDC--EGAAGVCR-K 697
Query: 612 AYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHK---NEPLIIKDDEDVRENIIRYD 668
A + GL + A++ IL I+ LL++++L + R + EPL+ +D D R+N+ YD
Sbjct: 698 AQPVEAGLQIPAILGILGGILALLILILLLLLFLRRRAVVKEPLLPPED-DTRDNVYYYD 756
Query: 669 DEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVR 728
+EGGGEED + FD++ L + R D+ P L +PR P N ++ FI+
Sbjct: 757 EEGGGEEDQD-FDLSQLHRGLDARPEVTRNDVAPTLMSVPRYLPRPA-NPDEIGNFIDEN 814
Query: 729 LHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGE 788
L AD DPTAPPYDS+ ++ YEG GS A SLSSL S+ SD DQ++DYL++WG RFK+L +
Sbjct: 815 LKAADTDPTAPPYDSLLVFDYEGSGSEAASLSSLNSSESDKDQDYDYLNEWGNRFKKLAD 874
Query: 789 LYSVGESD 796
+Y GE D
Sbjct: 875 MYGGGEDD 882
>gi|4826669 cadherin 15 preproprotein [Homo sapiens]
Length = 814
Score = 363 bits (933), Expect = e-100
Identities = 251/757 (33%), Positives = 397/757 (52%), Gaps = 38/757 (5%)
Query: 56 LNRSKRGWVWNQMFVLEEFSG-PEPILVGRLHTDLDPGSKKIKYILSGDGAGT----IFQ 110
L+R +R WV + V E P P++ ++ +D I Y + G G +F
Sbjct: 40 LSRVRRAWVIPPISVSENHKRLPYPLV--QIKSDKQQLGSVI-YSIQGPGVDEEPRGVFS 96
Query: 111 INDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNG 170
I+ TG + LDRE+ + L A A+D S LE P++ I V D NDN P FL
Sbjct: 97 IDKFTGKVFLNAMLDREKTDRFRLRAFALDLGGST-LEDPTDLEIVVVDQNDNRPAFLQE 155
Query: 171 PYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILE-GQP-YFSIEPETAIIKTA 228
+ V E ++ GT VT ATDADDP N+A L +SIL+ G P FSI+ T I+T
Sbjct: 156 AFTGRVLEGAVPGTYVTRAEATDADDPETDNAA-LRFSILQQGSPELFSIDELTGEIRTV 214
Query: 229 LPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPED 288
+DRE Y + +Q DM G GL+ T + +TL D+NDN P+F + + E
Sbjct: 215 QVGLDREVVAVYNLTLQVADMSGD--GLTATASAIITLDDINDNAPEFTRDEFFMEAIE- 271
Query: 289 VVLGTAIGRVKANDQDI--GENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFE 346
V G +GR++ D+D+ N + + I++GD F I +D + +G++ + K LD+E
Sbjct: 272 AVSGVDVGRLEVEDRDLPGSPNWVARFTILEGDPDGQFTIRTDPKTNEGVLSIVKALDYE 331
Query: 347 TKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAAL 406
+ + Y LKV N + + + A V++ V+D +EPPVF + E A
Sbjct: 332 SCEHYELKVSVQN-EAPLQAAALRAERGQAKVRVHVQDTNEPPVFQENPLRTSLAEGAPP 390
Query: 407 NSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKIT---LATPLDRELSV-WH 462
+++ +ARDPD T R S + D E ++A G+I + +P L W+
Sbjct: 391 GTLVATFSARDPD-TEQLQRLSYSKDYDPEDWLQVDAATGRIQTQHVLSPASPFLKGGWY 449
Query: 463 NITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDK 522
++A + + + + ++I++L+VND+AP A LC G + + A D+
Sbjct: 450 RAIVLAQDDASQPRTATGTLSIEILEVNDHAPVLAPPPPGSLCSEPHQGPGL-LLGATDE 508
Query: 523 DDPKNGHYFLYSLLPEMVN-NPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDS 581
D P +G F + L P + N+++ + + + +H + + ++ L +++ DS
Sbjct: 509 DLPPHGAPFHFQLSPRLPELGRNWSLSQVNVSHARLRPRH----QVPEGLHRLSLLLRDS 564
Query: 582 GNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLF 641
G PP L + VC C DGV GLS+GAL+ +LA +LLLV+V+L
Sbjct: 565 GQPPQQREQPLNVTVCRCGKDGVCLPGAAALLAGGTGLSLGALVIVLASALLLLVLVLL- 623
Query: 642 VTLR-----RHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGIN---G 693
V LR + + + L+ +D+R+N++ YD++GGGEED +A+DI+ L++P ++ G
Sbjct: 624 VALRARFWKQSRGKGLLHGPQDDLRDNVLNYDEQGGGEEDQDAYDISQLRHPTALSLPLG 683
Query: 694 FLPRKDIKPDLQFMPRQGLAPVPNGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYEGRG 753
P + P + P+ + +D+ +FIN L AD+DP+ PPYD+ IY YEG G
Sbjct: 684 PPPLRRDAPQGRLHPQPPRVLPTSPLDIADFINDGLEAADSDPSVPPYDTALIYDYEGDG 743
Query: 754 SVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELY 790
SVAG+LSS+ S+ D DQ++DYL DWGPRF RL ++Y
Sbjct: 744 SVAGTLSSILSSQGDEDQDYDYLRDWGPRFARLADMY 780
>gi|14589891 cadherin 3, type 1 preproprotein [Homo sapiens]
Length = 829
Score = 343 bits (880), Expect = 4e-94
Identities = 259/766 (33%), Positives = 387/766 (50%), Gaps = 57/766 (7%)
Query: 53 QRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGT----I 108
+RIL R KR WV + V E GP P + +L ++ D +K I Y ++G GA + +
Sbjct: 99 KRILRRHKRDWVVAPISVPENGKGPFPQRLNQLKSNKDRDTK-IFYSITGPGADSPPEGV 157
Query: 109 FQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFL 168
F + TG + K LDREE A+Y L AV E +E P I V D ND+ P+F
Sbjct: 158 FAVEKETGWLLLNKPLDREEIAKYELFGHAVS-ENGASVEDPMNISIIVTDQNDHKPKFT 216
Query: 169 NGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP------YFSIEPET 222
+ +V E + GTSV VTATD DD +Y + + YSI +P F+I T
Sbjct: 217 QDTFRGSVLEGVLPGTSVMQVTATDEDDAIYTYNGVVAYSIHSQEPKDPHDLMFTIHRST 276
Query: 223 AIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYH 282
I +DRE EY + IQA DM G G + T V + D NDN P F Y
Sbjct: 277 GTISVISSGLDREKVPEYTLTIQATDMDGD--GSTTTAVAVVEILDANDNAPMFDPQKYE 334
Query: 283 FSVPEDVVLGTAIGRVKANDQDIGENA--QSSYDIIDGDGTALFEITSDAQAQDGIIRLR 340
VPE+ V G + R+ D D + +++Y I+ GD F IT+ ++ GI+ R
Sbjct: 335 AHVPENAV-GHEVQRLTVTDLDAPNSPAWRATYLIMGGDDGDHFTITTHPESNQGILTTR 393
Query: 341 KPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEV 400
K LDFE K +TL VE N + F + P TAT+ + VED +E PVF P+ ++EV
Sbjct: 394 KGLDFEAKNQHTLYVEVTN---EAPFVLKLP-TSTATIVVHVEDVNEAPVFVPPSKVVEV 449
Query: 401 HENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSV 460
E + TA DPD + I + I R D ++ D G++T LDRE
Sbjct: 450 QEGIPTGEPVCVYTAEDPDKENQKISYRILR--DPAGWLAMDPDSGQVTAVGTLDREDEQ 507
Query: 461 W-----HNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQ 515
+ + + ++A + + + + ++DVND+ P E N P V Q
Sbjct: 508 FVRNNIYEVMVLAMDNGSPPTTGTGTLLLTLIDVNDHGP--VPEPRQITICNQSP--VRQ 563
Query: 516 TVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLP 575
++ DKD + F L + ++ +T + NE+ +L+ KQ+ Y +
Sbjct: 564 VLNITDKDLSPHTSPFQAQLTDD--SDIYWTAEVNEEGDTVVLSLKKFL---KQDTYDVH 618
Query: 576 IIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVE---AYVLPIGLSMGALIAILACII 632
+ +SD GN + + VC C G V++C ++LP+ +GA++A+L
Sbjct: 619 LSLSDHGNK--EQLTVIRATVCDCH--GHVETCPGPWKGGFILPV---LGAVLALL---- 667
Query: 633 LLLVIVVLFVTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNP-DGI 691
LL++++L V +R EPL++ +D D R+N+ Y +EGGGEED + +DI L +
Sbjct: 668 FLLLVLLLLVRKKRKIKEPLLLPED-DTRDNVFYYGEEGGGEEDQD-YDITQLHRGLEAR 725
Query: 692 NGFLPRKDIKPDLQFMPRQGLAPVP-NGVDVDEFINVRLHEADNDPTAPPYDSIQIYGYE 750
+ R D+ P + +P P P N ++ FI L A+ DPTAPPYD++ ++ YE
Sbjct: 726 PEVVLRNDVAPTI--IPTPMYRPRPANPDEIGNFIIENLKAANTDPTAPPYDTLLVFDYE 783
Query: 751 GRGSVAGSLSSLESTTSDSDQNFDYLSDWGPRFKRLGELYSVGESD 796
G GS A SLSSL S+ SD DQ++DYL++WG RFK+L ++Y GE D
Sbjct: 784 GSGSDAASLSSLTSSASDQDQDYDYLNEWGSRFKKLADMYGGGEDD 829
>gi|13435361 desmocollin 1 isoform Dsc1a preproprotein [Homo
sapiens]
Length = 894
Score = 249 bits (637), Expect = 5e-66
Identities = 226/787 (28%), Positives = 359/787 (45%), Gaps = 80/787 (10%)
Query: 56 LNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAG----TIFQI 111
L RSKR W ++E GP P V ++ +D + I Y +SG G +F I
Sbjct: 129 LKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPGVDKEPFNLFYI 187
Query: 112 NDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGP 171
TGDI + +DRE+ ++ L A + P E P IIK++D NDNAP F +
Sbjct: 188 EKDTGDIFCTRSIDREKYEQFALYGYATTADGYAP-EYPLPLIIKIEDDNDNAPYFEHRV 246
Query: 172 YHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP----YFSIEPETAIIKT 227
TVPE GTSV VTATD D+P ++ +L Y IL+ P +FSI P+T +I T
Sbjct: 247 TIFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITT 305
Query: 228 ALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPE 287
P +DRE + Y ++++ +DMGG GL T T+T++L D NDNPP F ++ Y V E
Sbjct: 306 TTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEE 365
Query: 288 DVVLGTAIGRVKANDQDIGENAQSS--YDIIDGDGTALFEITSDAQAQDGIIRLRKPLDF 345
+ + I R+K DQD+ S Y I+ G+ F I++D +G++ + KPL++
Sbjct: 366 NRI-DVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNY 424
Query: 346 ETKKSYTLKVEAAN-VHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENA 404
E + L+V N S + P T TV + + D+DE P P +++ +
Sbjct: 425 EVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGF 484
Query: 405 ALNSVIGQVTARDPDITSSP-IRFSIDRHTDLERQFNINADDGKITLATPLDRELSV--- 460
+ A DP+I+S +R+ + D + F IN G + LDRE
Sbjct: 485 PAGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKN 542
Query: 461 -WHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSA 519
+NI+++A + S + V + D ND+AP+ + E +C+N + V++ V
Sbjct: 543 NQYNISVVAVDAVGRSCTGTLVVHLD--DYNDHAPQI--DKEVTICQNNEDFAVLKPV-- 596
Query: 520 MDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIIS 579
D D P+NG F + L N N + +D +IL + + Y +PI I
Sbjct: 597 -DPDGPENGPPFQFFLDNSASKNWNI---EEKDGKTAILRQRQNLD---YNYYSVPIQIK 649
Query: 580 DSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMG---ALIAILACIILLLV 636
D L +T LT+RVC CS + + + + +G L +L ++LL +
Sbjct: 650 DRHG--LVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCI 707
Query: 637 IVVLF-VTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQNPDGIN--- 692
+ F VT +R + ++ ++N+I + EG GEE TEA +Q + +
Sbjct: 708 LFTCFCVTAKRTVKKCF---PEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSM 764
Query: 693 --GFLPRKDIKPDLQFMPRQG-----------------LAPVPNG-------VDVDEFIN 726
G + + IK F +G + V G D F
Sbjct: 765 SVGTVGGQGIKTQQSFEMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQ 824
Query: 727 VRLHE-----ADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWGP 781
RL E ++ D + Y YEG+GS+AGS+ + ++ ++L P
Sbjct: 825 PRLGEKVYLCGQDEEHKHCEDYVCSYNYEGKGSLAGSVGC--CSDRQEEEGLEFLDHLEP 882
Query: 782 RFKRLGE 788
+F+ L +
Sbjct: 883 KFRTLAK 889
>gi|4826702 desmocollin 1 isoform Dsc1b preproprotein [Homo sapiens]
Length = 840
Score = 245 bits (626), Expect = 1e-64
Identities = 199/644 (30%), Positives = 311/644 (48%), Gaps = 44/644 (6%)
Query: 56 LNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAG----TIFQI 111
L RSKR W ++E GP P V ++ +D + I Y +SG G +F I
Sbjct: 129 LKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQ-NYTIFYSISGPGVDKEPFNLFYI 187
Query: 112 NDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGP 171
TGDI + +DRE+ ++ L A + P E P IIK++D NDNAP F +
Sbjct: 188 EKDTGDIFCTRSIDREKYEQFALYGYATTADGYAP-EYPLPLIIKIEDDNDNAPYFEHRV 246
Query: 172 YHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP----YFSIEPETAIIKT 227
TVPE GTSV VTATD D+P ++ +L Y IL+ P +FSI P+T +I T
Sbjct: 247 TIFTVPENCRSGTSVGKVTATDLDEPDTLHT-RLKYKILQQIPDHPKHFSIHPDTGVITT 305
Query: 228 ALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPE 287
P +DRE + Y ++++ +DMGG GL T T+T++L D NDNPP F ++ Y V E
Sbjct: 306 TTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEE 365
Query: 288 DVVLGTAIGRVKANDQDIGENAQSS--YDIIDGDGTALFEITSDAQAQDGIIRLRKPLDF 345
+ + I R+K DQD+ S Y I+ G+ F I++D +G++ + KPL++
Sbjct: 366 NRI-DVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNY 424
Query: 346 ETKKSYTLKVEAAN-VHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENA 404
E + L+V N S + P T TV + + D+DE P P +++ +
Sbjct: 425 EVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGF 484
Query: 405 ALNSVIGQVTARDPDITSSP-IRFSIDRHTDLERQFNINADDGKITLATPLDRELSV--- 460
+ A DP+I+S +R+ + D + F IN G + LDRE
Sbjct: 485 PAGQELLGYKALDPEISSGEGLRY--QKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKN 542
Query: 461 -WHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSA 519
+NI+++A + S + V + D ND+AP+ + E +C+N + V++ V
Sbjct: 543 NQYNISVVAVDAVGRSCTGTLVVHLD--DYNDHAPQI--DKEVTICQNNEDFAVLKPV-- 596
Query: 520 MDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIIS 579
D D P+NG F + L N N + +D +IL + + Y +PI I
Sbjct: 597 -DPDGPENGPPFQFFLDNSASKNWNI---EEKDGKTAILRQRQNLD---YNYYSVPIQIK 649
Query: 580 DSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMG---ALIAILACIILLLV 636
D L +T LT+RVC CS + + + + +G L +L ++LL +
Sbjct: 650 DRHG--LVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCI 707
Query: 637 IVVLF-VTLRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEA 679
+ F VT +R + ++ ++N+I + EG GEE TEA
Sbjct: 708 LFTCFCVTAKRTVKKCF---PEDIAQQNLIVSNTEGPGEEVTEA 748
>gi|4502719 cadherin 13 preproprotein [Homo sapiens]
Length = 713
Score = 231 bits (589), Expect = 2e-60
Identities = 199/598 (33%), Positives = 292/598 (48%), Gaps = 43/598 (7%)
Query: 58 RSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGT----IFQIND 113
R KR V + + + E P P VG++ P ++ K+ L+G G IF+IN+
Sbjct: 135 RQKRSIVVSPILIPENQRQPFPRDVGKVVDSDRP--ERSKFRLTGKGVDQEPKGIFRINE 192
Query: 114 VTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYH 173
TG + + LDRE A Y L + D K LE P + V D NDN P F GPY
Sbjct: 193 NTGSVSVTRTLDREVIAVYQLFVETTD-VNGKTLEGPVPLEVIVIDQNDNRPIFREGPYI 251
Query: 174 ATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP------YFSIEPETAIIKT 227
V E S GT+V +TA DADDP N A L Y+I + P F I+PE I T
Sbjct: 252 GHVMEGSPTGTTVMRMTAFDADDPATDN-ALLRYNIRQQTPDKPSPNMFYIDPEKGDIVT 310
Query: 228 ALPN--MDREAKE--EYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHF 283
+ +DRE E +Y ++I+A+DM G GL+GT T T+ + D ND+ PKF + +
Sbjct: 311 VVSPALLDRETLENPKYELIIEAQDMAGLDVGLTGTATATIMIDDKNDHSPKFTKKEFQA 370
Query: 284 SVPEDVVLGTAIGRVKANDQDIGENA-QSSYDIIDGDGTALFEITSDAQAQDGIIRLRKP 342
+V E V G + + D A +++Y II+G+ FEI ++ Q +G++ + KP
Sbjct: 371 TVEEGAV-GVIVNLTVEDKDDPTTGAWRAAYTIINGNPGQSFEIHTNPQTNEGMLSVVKP 429
Query: 343 LDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHE 402
LD+E +TL ++ N GP TATV I V D +E PVF ++ E
Sbjct: 430 LDYEISAFHTLLIKVENEDPLVPDVSYGP-SSTATVHITVLDVNEGPVFYPDPMMVTRQE 488
Query: 403 NAALNSVIGQVTARDPD-ITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVW 461
+ ++ SV+ V A DPD + IR+S+ + D NIN +G + LDRE
Sbjct: 489 DLSVGSVLLTVNATDPDSLQHQTIRYSV--YKDPAGWLNINPINGTVDTTAVLDRESPFV 546
Query: 462 HN----ITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTV 517
N +A + N + I + DVNDNAP F A +C++ K V+ +
Sbjct: 547 DNSVYTALFLAIDSGNPPATGTGTLLITLEDVNDNAP-FIYPTVAEVCDDAKNLSVV-IL 604
Query: 518 SAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKK--NEDNSLSILAKHNGFNRQKQEVYLLP 575
A DKD N F + + + V + + I K N +S+L N N Y LP
Sbjct: 605 GASDKDLHPNTDPFKFEIHKQAVPDKVWKISKINNTHALVSLLQNLNKAN------YNLP 658
Query: 576 IIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAI--LACI 631
I+++DSG PP+++ + L ++VC C N V CN A L L L+++ LAC+
Sbjct: 659 IMVTDSGKPPMTNITDLRVQVCSCRNSKV--DCNA-AGALRFSLPSVLLLSLFSLACL 713
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 229 bits (585), Expect = 6e-60
Identities = 180/530 (33%), Positives = 271/530 (51%), Gaps = 37/530 (6%)
Query: 77 PEPILVGRL-----HTDLDPGSK-KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKA 130
PE +L G+L TD D S +I Y L G GA F++N TG++ LDREE+A
Sbjct: 3033 PEDVLPGKLIMQISATDADIRSNAEITYTLLGSGAEK-FKLNPDTGELKTSTPLDREEQA 3091
Query: 131 EYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVT 190
Y L +A D + ++ ++D+NDNAPEF PY TV E + GT +T V
Sbjct: 3092 VYHLLVRATD---GGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQ 3148
Query: 191 ATDADDPVYGNSAKLVYSILEGQP-YFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDM 249
ATDAD G + K++YS+++ FSI + II+ P +DRE + Y + ++A D
Sbjct: 3149 ATDADA---GLNRKILYSLIDSADGQFSINELSGIIQLEKP-LDRELQAVYTLSLKAVDQ 3204
Query: 250 GGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENA 309
G L+ T T+ V++ D+NDNPP F Y +V ED+++GT + +V A +DI NA
Sbjct: 3205 G-LPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANA 3263
Query: 310 QSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGR 369
+ +Y II G+ F I S + G + + + LD+E+ Y L VEA + G
Sbjct: 3264 EITYSIISGNEHGKFSIDS----KTGAVFIIENLDYESSHEYYLTVEATD-------GGT 3312
Query: 370 GPFKDTATVKIVVEDA-DEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITS-SPIRF 427
D ATV + V D D PVFS TY + E+A L + V A D D S S I +
Sbjct: 3313 PSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDADGPSNSHIHY 3372
Query: 428 SIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVL 487
SI F I+ G++ + LDRE + +T+ A++ + +++ V I V
Sbjct: 3373 SIIDGNQ-GSSFTIDPVRGEVKVTKLLDRETISGYTLTVQASDNGSPPRVNTTTVNIDVS 3431
Query: 488 DVNDNAPEFA-SEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFT 546
DVNDNAP F+ Y + EN G + + D+D NG F ++++ N
Sbjct: 3432 DVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSHNGPPFFFTIV---TGNDE-- 3486
Query: 547 IKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
K E N +L + R++++ YLL + ++D+G P LSS + + IRV
Sbjct: 3487 -KAFEVNPQGVLLTSSAIKRKEKDHYLLQVKVADNGKPQLSSLTYIDIRV 3535
Score = 204 bits (519), Expect = 3e-52
Identities = 162/518 (31%), Positives = 249/518 (48%), Gaps = 32/518 (6%)
Query: 87 TDLDPG-SKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSK 145
TDLD G + K+ Y +SG + F I+ TG + + LDRE +YTL D
Sbjct: 742 TDLDTGFNGKLVYAVSGGNEDSCFMIDMETGMLKILSPLDRETTDKYTLNITVYD--LGI 799
Query: 146 PLEPPSEFI-IKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAK 204
P + + + V D NDN PEFL Y V E + + + V ATD D G +
Sbjct: 800 PQKAAWRLLHVVVVDANDNPPEFLQESYFVEVSEDKEVHSEIIQVEATDKD---LGPNGH 856
Query: 205 LVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTV 264
+ YSI+ FSI+ T ++ A P +DRE + E+ + I+A+D L T + V
Sbjct: 857 VTYSIVTDTDTFSIDSVTGVVNIARP-LDRELQHEHSLKIEARDQAREEPQLFSTVVVKV 915
Query: 265 TLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIID-GDGTAL 323
+L DVNDNPP F Y V ED+ GT I ++A+D D+G++ Q Y ++D G+G
Sbjct: 916 SLEDVNDNPPTFIPPNYRVKVREDLPEGTVIMWLEAHDPDLGQSGQVRYSLLDHGEG--- 972
Query: 324 FEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVE 383
D G +R+ + LDFE K+ Y L V A + S T V++ V
Sbjct: 973 ---NFDVDKLSGAVRIVQQLDFEKKQVYNLTVRAKDKGKPVSLS------STCYVEVEVV 1023
Query: 384 DADE---PPVFSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQF 439
D +E PPVFSS V E+A + S++ V+A D D IR+SI R F
Sbjct: 1024 DVNENLHPPVFSSFVEKGTVKEDAPVGSLVMTVSAHDEDARRDGEIRYSI-RDGSGVGVF 1082
Query: 440 NINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASE 499
I + G I + LDRE + + +T+ AT+ S + + I+V DVNDNAP+ +
Sbjct: 1083 KIGEETGVIETSDRLDRESTSHYWLTVFATDQGVVPLSSFIEIYIEVEDVNDNAPQTSEP 1142
Query: 500 -YEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSIL 558
Y + EN + + A D D N +Y + NP + L I
Sbjct: 1143 VYYPEIMENSPKDVSVVQIEAFDPDSSSNDK-LMYKITS---GNPQGFFSIHPKTGL-IT 1197
Query: 559 AKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
+R++Q+ ++L + ++D+G+PP S+ + + +++
Sbjct: 1198 TTSRKLDREQQDEHILEVTVTDNGSPPKSTIARVIVKI 1235
Score = 197 bits (500), Expect = 4e-50
Identities = 166/550 (30%), Positives = 272/550 (49%), Gaps = 44/550 (8%)
Query: 88 DLDPGSKKIKYILSGDGAGTIFQINDVTGD--IHAIKRLDREEKAEYTLTAQAVDWETSK 145
D + ++++ Y ++G F + + + ++ K LDRE++ Y LT A D S
Sbjct: 2946 DSEEINRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDNYLLTITATDGTFSS 3005
Query: 146 PLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKL 205
+ +KV D NDN+P Y T+PE + G + ++ATDAD ++A++
Sbjct: 3006 K----AIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQISATDAD---IRSNAEI 3058
Query: 206 VYSIL-EGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTV 264
Y++L G F + P+T +KT+ P +DRE + Y ++++A D GG S + +
Sbjct: 3059 TYTLLGSGAEKFKLNPDTGELKTSTP-LDREEQAVYHLLVRATDGGGRFCQAS----IVL 3113
Query: 265 TLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIID-GDGTAL 323
TL DVNDN P+F+ Y +V E+ GT + RV+A D D G N + Y +ID DG
Sbjct: 3114 TLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDADAGLNRKILYSLIDSADGQ-- 3171
Query: 324 FEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVE 383
F I GII+L KPLD E + YTL ++A + + R + G + V++
Sbjct: 3172 FSINE----LSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLTATG-----TVIVSVLD 3222
Query: 384 DADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNIN 442
D PPVF Y V E+ + + + QV A DI ++ I +SI + +F+I+
Sbjct: 3223 INDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAEITYSIISGNE-HGKFSID 3281
Query: 443 ADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASE-YE 501
+ G + + LD E S + +T+ AT+ S V + V D+NDN P F+ + Y
Sbjct: 3282 SKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVATVNVNVTDINDNTPVFSQDTYT 3341
Query: 502 AFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIK--KNEDNSLSILA 559
+ E+ Q + TV A D D P N H YS++ + +FTI + E +L
Sbjct: 3342 TVISEDAVLEQSVITVMADDADGPSNSHIH-YSII-DGNQGSSFTIDPVRGEVKVTKLL- 3398
Query: 560 KHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVL---- 615
+R+ Y L + SD+G+PP +T+T+ I V +++ V S + ++
Sbjct: 3399 -----DRETISGYTLTVQASDNGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENK 3453
Query: 616 PIGLSMGALI 625
P+G S+ L+
Sbjct: 3454 PVGFSVLQLV 3463
Score = 182 bits (463), Expect = 8e-46
Identities = 158/484 (32%), Positives = 235/484 (48%), Gaps = 36/484 (7%)
Query: 69 FVLEEFSGPEP--ILVGRLHTDLDPG-SKKIKYILSGDGAGTIFQINDVTGDIHAIKRLD 125
+ + F EP +L TD D G ++KI Y L D A F IN+++G I K LD
Sbjct: 3130 YAITVFENTEPGTLLTRVQATDADAGLNRKILYSLI-DSADGQFSINELSGIIQLEKPLD 3188
Query: 126 REEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTS 185
RE +A YTL+ +AVD + L I+ V DINDN P F Y ATV E ++GT
Sbjct: 3189 RELQAVYTLSLKAVDQGLPRRLTATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTE 3248
Query: 186 VTNVTATDADDPVYGNSAKLVYSILEGQPY--FSIEPETAIIKTALPNMDREAKEEYLVV 243
V V A D +A++ YSI+ G + FSI+ +T + + N+D E+ EY +
Sbjct: 3249 VLQVYAASRDIEA---NAEITYSIISGNEHGKFSIDSKTGAV-FIIENLDYESSHEYYLT 3304
Query: 244 IQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQ 303
++A D G + LS T+ V +TD+NDN P F+Q Y + ED VL ++ V A+D
Sbjct: 3305 VEATD--GGTPSLSDVATVNVNVTDINDNTPVFSQDTYTTVISEDAVLEQSVITVMADDA 3362
Query: 304 DIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHID 363
D N+ Y IIDG+ + F I G +++ K LD ET YTL V+A++
Sbjct: 3363 DGPSNSHIHYSIIDGNQGSSFTI----DPVRGEVKVTKLLDRETISGYTLTVQASD---- 3414
Query: 364 PRFSGRGPFKDTATVKIVVEDA-DEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITS 422
+G P +T TV I V D D PVFS Y + + EN + + Q+ D D +
Sbjct: 3415 ---NGSPPRVNTTTVNIDVSDVNDNAPVFSRGNYSVIIQENKPVGFSVLQLVVTDEDSSH 3471
Query: 423 S--PIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRV 480
+ P F+I D E+ F +N +T + +E H + + Q+S +
Sbjct: 3472 NGPPFFFTIVTGND-EKAFEVNPQGVLLTSSAIKRKEKD--HYLLQVKVADNGKPQLSSL 3528
Query: 481 P-VAIKVLDVNDNAPEFASEYEAFLCENGK--PGQVIQTVSAMDKDDPKNGHYFLYSLLP 537
+ I+V++ + P E F+ +G+ G VI + A D+D YSL P
Sbjct: 3529 TYIDIRVIEESIYPPAIL-PLEIFITSSGEEYSGGVIGKIHATDQDVYDT---LTYSLDP 3584
Query: 538 EMVN 541
+M N
Sbjct: 3585 QMDN 3588
Score = 172 bits (437), Expect = 8e-43
Identities = 159/557 (28%), Positives = 249/557 (44%), Gaps = 51/557 (9%)
Query: 67 QMFVLEEFSGPEPILVGRLHTDLDPGSK-KIKYILSGDGAGTI---FQINDVTGDIHAIK 122
+ F++E G ++ R +D D G+ ++ Y L + + F IN TG I +K
Sbjct: 2815 EAFIVENLPGGSRVIQIRA-SDADSGTNGQVMYSLDQSQSVEVIESFAINMETGWITTLK 2873
Query: 123 RLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSIL 182
LD E++ Y + A D L + + V D+ND+ P F Y TV E
Sbjct: 2874 ELDHEKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQ 2933
Query: 183 GTSVTNVTATDADDPVYGNSAKLVYSILEGQP--YFSIEPETAIIKTALPN-MDREAKEE 239
G + ++ TDAD + ++ Y I G P F++E K + +DRE ++
Sbjct: 2934 GGVIAILSTTDADSEEI--NRQVTYFITGGDPLGQFAVETIQNEWKVYVKKPLDREKRDN 2991
Query: 240 YLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVK 299
YL+ I A D G S + V + D NDN P ++LY ++PEDV+ G I ++
Sbjct: 2992 YLLTITATD-----GTFSSKAIVEVKVLDANDNSPVCEKTLYSDTIPEDVLPGKLIMQIS 3046
Query: 300 ANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAAN 359
A D DI NA+ +Y ++ G G F++ D G ++ PLD E + Y L V A +
Sbjct: 3047 ATDADIRSNAEITYTLL-GSGAEKFKLNPDT----GELKTSTPLDREEQAVYHLLVRATD 3101
Query: 360 VHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPD 419
G G F + V + + D P FS+ Y + V EN +++ +V A D D
Sbjct: 3102 --------GGGRFCQASIVLTLEDVNDNAPEFSADPYAITVFENTEPGTLLTRVQATDAD 3153
Query: 420 I-TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQIS 478
+ I +S+ D QF+IN G I L PLDREL + +++ A + +++
Sbjct: 3154 AGLNRKILYSLIDSAD--GQFSINELSGIIQLEKPLDRELQAVYTLSLKAVDQGLPRRLT 3211
Query: 479 RV-PVAIKVLDVNDNAPEFA-SEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLL 536
V + VLD+NDN P F EY A + E+ G + V A +D N YS+
Sbjct: 3212 ATGTVIVSVLDINDNPPVFEYREYGATVSEDILVGTEVLQVYAASRDIEANAE-ITYSI- 3269
Query: 537 PEMVNNPNFTIKKNEDNSLSILAKH------NGFNRQKQEVYLLPIIISDSGNPPLSSTS 590
I NE SI +K + + Y L + +D G P LS +
Sbjct: 3270 ----------ISGNEHGKFSIDSKTGAVFIIENLDYESSHEYYLTVEATDGGTPSLSDVA 3319
Query: 591 TLTIRVCGCSNDGVVQS 607
T+ + V +++ V S
Sbjct: 3320 TVNVNVTDINDNTPVFS 3336
Score = 155 bits (393), Expect = 1e-37
Identities = 147/516 (28%), Positives = 235/516 (45%), Gaps = 53/516 (10%)
Query: 96 IKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFII 155
+ Y + G F IN +G I K LD E YTL Q + L + ++
Sbjct: 1697 VVYEIKDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAG---LSTNTTVLV 1753
Query: 156 KVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVY--------GNSAKLVY 207
+QD NDNAP F+ Y + E + S+ +V TD + P+ ++A LVY
Sbjct: 1754 HLQDENDNAPVFMQAEYTGLISESA----SINSVVLTDRNVPLVIRAADADKDSNALLVY 1809
Query: 208 SILEGQ--PYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVT 265
I+E YF+I+ T I T L ++D E + +Q DMG +TV
Sbjct: 1810 HIVEPSVHTYFAIDSSTGAIHTVL-SLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTVH 1868
Query: 266 LTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFE 325
+ D+ND PP FA+ LY S+ G + V A D D +Q Y I +G+ F
Sbjct: 1869 VIDINDCPPVFAKPLYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGNIGEKFS 1928
Query: 326 ITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDA 385
+ + G + ++ ++ Y L V A+ D RF+G +VKI V+++
Sbjct: 1929 M----DYKTGALTVQNTTQLRSR--YELTVRAS----DGRFAG------LTSVKINVKES 1972
Query: 386 DEPPV-FSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINAD 444
E + F+ Y V EN+ + +TA I + P+ + I + +R+F I+
Sbjct: 1973 KESHLKFTQDVYSAVVKENSTEAETLAVITAIGNPI-NEPLFYHI---LNPDRRFKISRT 2028
Query: 445 DGKI-TLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFAS-EYEA 502
G + T TP DRE ++ + TE S ++ V V + V D NDNAP F + Y A
Sbjct: 2029 SGVLSTTGTPFDREQQEAFDVVVEVTEEHKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYA 2088
Query: 503 FLCENGKPGQVIQTVSAMDKDDPKNG--HYFLYSLLPEMVNNPNFTIKKNEDNSLSILAK 560
+ + + G VI+ V+A+D+D +NG HY+L ++ +F I + SL +
Sbjct: 2089 VVKVDTEVGHVIRYVTAVDRDSGRNGEVHYYLKE------HHEHFQIGPLGEISLKKQFE 2142
Query: 561 HNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
+ N++ YL+ ++ D GNP S+ + I V
Sbjct: 2143 LDTLNKE----YLVTVVAKDGGNPAFSAEVIVPITV 2174
Score = 153 bits (387), Expect = 5e-37
Identities = 144/514 (28%), Positives = 234/514 (45%), Gaps = 37/514 (7%)
Query: 91 PGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPP 150
P K+ Y ++ + F IN TG I+ I LD E Y L+ +A D T E
Sbjct: 2209 PEGLKVFYSITDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAHAEVF 2268
Query: 151 SEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDAD-DPVYGNSAKLVYSI 209
+ I V DINDN P F Y T+ E S++GTSV V ATD+D +P G S ++ +
Sbjct: 2269 VDII--VDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNH 2326
Query: 210 LEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDV 269
+ +F ++ T +I + L +D E ++ + ++A D G + LS +TV +TD+
Sbjct: 2327 SKSHDHFHVDSSTGLI-SLLRTLDYEQSRQHTIFVRAVDGGMPT--LSSDVIVTVDVTDL 2383
Query: 270 NDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSD 329
NDNPP F Q +Y + E G + VKA D D + + Y I+ G+ F I S
Sbjct: 2384 NDNPPLFEQQIYEARISEHAPHGHFVTCVKAYDADSSDIDKLQYSILSGNDHKHFVIDS- 2442
Query: 330 AQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDAD-EP 388
GII L K Y+L + ++ G F+ + V + V +
Sbjct: 2443 ---ATGIITLSNLHRHALKPFYSLNLSVSD----------GVFRSSTQVHVTVIGGNLHS 2489
Query: 389 PVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRH--TDLER-QFNINADD 445
P F Y +E+ ENA L++++ +V D D S I + H D + +F IN +
Sbjct: 2490 PAFLQNEYEVELAENAPLHTLVMEVKTTDGD---SGIYGHVTYHIVNDFAKDRFYIN-ER 2545
Query: 446 GKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEF-ASEYEAFL 504
G+I LDRE I++ +++ V + + D NDNAP+F A++YE +
Sbjct: 2546 GQIFTLEKLDRETPAEKVISVRLMAKDAGGKVAFCTVNVILTDDNDNAPQFRATKYEVNI 2605
Query: 505 CENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKN-EDNSLS-ILAKHN 562
+ G + V A D D+ N + + + ++K+N E N LS ++
Sbjct: 2606 GSSAAKGTSVVKVLASDADEGSNAD------ITYAIEADSESVKENLEINKLSGVITTKE 2659
Query: 563 GFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
+ E + + D+G+P S + +++
Sbjct: 2660 SLIGLENEFFTFFVRAVDNGSPSKESVVLVYVKI 2693
Score = 147 bits (371), Expect = 4e-35
Identities = 136/536 (25%), Positives = 232/536 (43%), Gaps = 52/536 (9%)
Query: 75 SGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTL 134
S P ++G + ++P + + ++G + F ++ TG I K LD E+K+ Y L
Sbjct: 1370 SDPVAHMIGVI--SVEPPGIPLWFDITGGNYDSHFDVDKGTGTIIVAKPLDAEQKSNYNL 1427
Query: 135 TAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDA 194
T +A D T+ ++ IKV D ND+ P+F Y +PE + T + ++A D
Sbjct: 1428 TVEATDGTTTIL----TQVFIKVIDTNDHRPQFSTSKYEVVIPEDTAPETEILQISAVDQ 1483
Query: 195 DDPVYGNSAKLVYSILEGQP-----YFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDM 249
D+ KL+Y++ + F ++P T + T+ +D EA ++ + + +D
Sbjct: 1484 DE-----KNKLIYTLQSSRDPLSLKKFRLDPATGSLYTS-EKLDHEAVHQHTLTVMVRDQ 1537
Query: 250 GGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENA 309
+ V ++D ND+ P F S Y V E +G+ + +V A D+D G+NA
Sbjct: 1538 DVPVK--RNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNA 1595
Query: 310 QSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGR 369
+ Y I G+ F I G I+ K LD + Y L V+A + G
Sbjct: 1596 EVLYSIESGNIGNSFMIDPVL----GSIKTAKELDRSNQAEYDLMVKATD-------KGS 1644
Query: 370 GPFKDTATVKIVVEDADE-PPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFS 428
P + +V+I V AD P F+S Y +E+ E ++ S +G VTA + S + +
Sbjct: 1645 PPMSEITSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMVTAH----SQSSVVYE 1700
Query: 429 IDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLD 488
I + + F+IN G I LD E + + I T + S + V + + D
Sbjct: 1701 I-KDGNTGDAFDINPHSGTIITQKALDFETLPIYTLIIQGTNMAGLS--TNTTVLVHLQD 1757
Query: 489 VNDNAPEF-ASEYEAFLCENGKPGQVIQT-------VSAMDKDDPKNGHYFLYSLLPEMV 540
NDNAP F +EY + E+ V+ T + A D D N +LL +
Sbjct: 1758 ENDNAPVFMQAEYTGLISESASINSVVLTDRNVPLVIRAADADKDSN------ALLVYHI 1811
Query: 541 NNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
P+ D+S + + ++ ++ + + D G P L + + V
Sbjct: 1812 VEPSVHTYFAIDSSTGAIHTVLSLDYEETSIFHFTVQVHDMGTPRLFAEYAANVTV 1867
Score = 143 bits (360), Expect = 7e-34
Identities = 155/579 (26%), Positives = 253/579 (43%), Gaps = 65/579 (11%)
Query: 75 SGPEPILVGRLHTDLDPGSK---KIKYILSGDGAGTIFQINDVTGDIHAIKR-LDREEKA 130
+ P+ + V ++ DP S K+ Y ++ F I+ TG I R LDRE++
Sbjct: 1151 NSPKDVSVVQIEA-FDPDSSSNDKLMYKITSGNPQGFFSIHPKTGLITTTSRKLDREQQD 1209
Query: 131 EYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVP-------EMSILG 183
E+ L D S P + I+K+ D NDN P+FL Y +P E +
Sbjct: 1210 EHILEVTVTD-NGSPPKSTIARVIVKILDENDNKPQFLQKFYKIRLPEREKPDRERNARR 1268
Query: 184 TSVTNVTATDADDPVYGNSAKLVYSILEGQPY--FSIEPETAIIKTALPNMDREAKEEYL 241
+ +V ATD D+ G +A++ YSI +G + F IEP+T ++ + A E +
Sbjct: 1269 EPLYHVIATDKDE---GPNAEISYSIEDGNEHGKFFIEPKTGVVSS---KRFSAAGEYDI 1322
Query: 242 VVIQAKDMGGHSGGLSGTTTL---TVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRV 298
+ I+A D G S TT L ++ + P F +S + F+V E + IG +
Sbjct: 1323 LSIKAVDNGRPQ--KSSTTRLHIEWISKPKPSLEPISFEESFFTFTVMESDPVAHMIGVI 1380
Query: 299 KANDQDI-------GENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSY 351
I G N S +D+ G GT I + KPLD E K +Y
Sbjct: 1381 SVEPPGIPLWFDITGGNYDSHFDVDKGTGT---------------IIVAKPLDAEQKSNY 1425
Query: 352 TLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIG 411
L VEA + G +K V++ D P FS+ Y + + E+ A + I
Sbjct: 1426 NLTVEATD--------GTTTILTQVFIK-VIDTNDHRPQFSTSKYEVVIPEDTAPETEIL 1476
Query: 412 QVTARDPDITSSPIRFSIDRHTDLE-RQFNINADDGKITLATPLDRELSVWHNITIIATE 470
Q++A D D + I L ++F ++ G + + LD E H +T++ +
Sbjct: 1477 QISAVDQDEKNKLIYTLQSSRDPLSLKKFRLDPATGSLYTSEKLDHEAVHQHTLTVMVRD 1536
Query: 471 IRNHSQISRVPVAIKVLDVNDNAPEF-ASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGH 529
+ + + + V D ND+AP F AS Y+ + E+ G V+ V+A+DKD KN
Sbjct: 1537 QDVPVKRNFARIVVNVSDTNDHAPWFTASSYKGRVYESAAVGSVVLQVTALDKDKGKNAE 1596
Query: 530 YFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSST 589
LYS+ + N +F I D L + +R Q Y L + +D G+PP+S
Sbjct: 1597 -VLYSIESGNIGN-SFMI----DPVLGSIKTAKELDRSNQAEYDLMVKATDKGSPPMSEI 1650
Query: 590 STLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAIL 628
+++ I V N + + L +S+G+ + ++
Sbjct: 1651 TSVRIFVTIADNASPKFTSKEYSVELSETVSIGSFVGMV 1689
Score = 139 bits (350), Expect = 1e-32
Identities = 142/544 (26%), Positives = 234/544 (43%), Gaps = 35/544 (6%)
Query: 95 KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREE-KAEYTLTAQAVDWETSKPLEPPSEF 153
K++Y + F I+ TG I + L R K Y+L D ++
Sbjct: 2424 KLQYSILSGNDHKHFVIDSATGII-TLSNLHRHALKPFYSLNLSVSDGV----FRSSTQV 2478
Query: 154 IIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILE-- 211
+ V N ++P FL Y + E + L T V V TD D +YG+ + Y I+
Sbjct: 2479 HVTVIGGNLHSPAFLQNEYEVELAENAPLHTLVMEVKTTDGDSGIYGH---VTYHIVNDF 2535
Query: 212 GQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVND 271
+ F I I L +DRE E VI + M +GG T+ V LTD ND
Sbjct: 2536 AKDRFYINERGQIF--TLEKLDRETPAEK--VISVRLMAKDAGGKVAFCTVNVILTDDND 2591
Query: 272 NPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQ 331
N P+F + Y ++ GT++ +V A+D D G NA +Y I+ D ++ E +
Sbjct: 2592 NAPQFRATKYEVNIGSSAAKGTSVVKVLASDADEGSNADITY-AIEADSESVKE-NLEIN 2649
Query: 332 AQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTAT---VKIVVEDADEP 388
G+I ++ L + +T V A + P K++ VKI+ + +
Sbjct: 2650 KLSGVITTKESLIGLENEFFTFFVRAVD--------NGSPSKESVVLVYVKILPPEM-QL 2700
Query: 389 PVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKI 448
P FS P Y V E+ + + I + A + ++ + F I+ G++
Sbjct: 2701 PKFSEPFYTFTVSEDVPIGTEIDLIRAEHSGTVLYSLVKGNTPESNRDESFVIDRQSGRL 2760
Query: 449 TLATPLDRELSVWHNITIIATEIR-NHSQISRVPVAIKVLDVNDNAPEF-ASEYEAFLCE 506
L LD E + W+ +I+A + +H ++ V V+I+V D NDN+P F +S YEAF+ E
Sbjct: 2761 KLEKSLDHETTKWYQFSILARCTQDDHEMVASVDVSIQVKDANDNSPVFESSPYEAFIVE 2820
Query: 507 NGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNR 566
N G + + A D D NG +YSL + N + K +
Sbjct: 2821 NLPGGSRVIQIRASDADSGTNGQ-VMYSLDQSQSVEVIESFAINMETGWITTLKE--LDH 2877
Query: 567 QKQEVYLLPIIISDSGNP-PLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALI 625
+K++ Y + ++ SD G LSST+ + + V ++ + + + G +I
Sbjct: 2878 EKRDNYQIKVVASDHGEKIQLSSTAIVDVTVTDVNDSPPRFTAEIYKGTVSEDDPQGGVI 2937
Query: 626 AILA 629
AIL+
Sbjct: 2938 AILS 2941
Score = 118 bits (295), Expect = 2e-26
Identities = 132/526 (25%), Positives = 231/526 (43%), Gaps = 57/526 (10%)
Query: 124 LDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILG 183
L+RE K YTL +A++ T+ +E ++ ++V D ND P F Y ++PE + +
Sbjct: 108 LNREVKDHYTLIVKALEKNTN--VEARTKVRVQVLDTNDLRPLFSPTSYSVSLPENTAIR 165
Query: 184 TSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVV 243
TS+ V+ATDAD G + + YS + F+I P + +I +D + Y +
Sbjct: 166 TSIARVSATDAD---IGTNGEFYYSFKDRTDMFAIHPTSGVI-VLTGRLDYLETKLYEME 221
Query: 244 IQAKDMGGH---SGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKA 300
I A D G S G+S LTV + N+ P P ++ A V
Sbjct: 222 ILAADRGMKLYGSSGISSMAKLTVHIEQANECAPVITAVTLS---PSELDRDPAYAIVTV 278
Query: 301 NDQDIGENAQ-SSYDIIDGDGTALFE-ITSDAQAQDGIIRLRKPLDFETKK-SYTLKVEA 357
+D D G N +S I+ GD F + S +++ ++ +D+++ Y L ++A
Sbjct: 279 DDCDQGANGDIASLSIVAGDLLQQFRTVRSFPGSKEYKVKAIGGIDWDSHPFGYNLTLQA 338
Query: 358 ANVHIDPRFSGRGPFKDTATVKIVVEDADE----PPVFSSPTYLLEVHENAALNSVIGQV 413
+ P+FS +VK++ + + P F Y E+ E A N+ + V
Sbjct: 339 KDKGTPPQFS---------SVKVIHVTSPQFKAGPVKFEKDVYRAEISEFAPPNTPVVMV 389
Query: 414 TARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRN 473
A S +R+ + + T + +F++N + G I++ P+ R+ + + E+
Sbjct: 390 KAIP---AYSHLRY-VFKSTPGKAKFSLNYNTGLISILEPVKRQQAAHFEL-----EVTT 440
Query: 474 HSQISRVPVAIKVLDVNDNAPEFA-SEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFL 532
+ + V +KVL N N PEF + Y+A EN G + ++SA+D D+ +NG Y
Sbjct: 441 SDRKASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPDEGENG-YVT 499
Query: 533 YSL-----LPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLS 587
YS+ +P +++ + +E+ ++ + VY L I SD G P
Sbjct: 500 YSIANLNHVPFAIDHFTGAVSTSENLDYELMPR----------VYTLRIRASDWGLPYRR 549
Query: 588 STSTLTIRVCGCSNDG--VVQSCNVEAYVLPIGLSMGALIAILACI 631
L ND + + N E +P L +G I ++ I
Sbjct: 550 EVEVLATITLNNLNDNTPLFEKINCEG-TIPRDLGVGEQITTVSAI 594
Score = 112 bits (279), Expect = 2e-24
Identities = 136/535 (25%), Positives = 222/535 (41%), Gaps = 39/535 (7%)
Query: 64 VWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKR 123
++ +L + G + I V D S+ I I G+ G F ++ TG + +
Sbjct: 1883 LYEASLLLPTYKGVKVITVNATDADSSAFSQLIYSITEGN-IGEKFSMDYKTGALTV--Q 1939
Query: 124 LDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILG 183
+ ++ Y LT +A D + + I V++ ++ +F Y A V E S
Sbjct: 1940 NTTQLRSRYELTVRASDGRFAGL----TSVKINVKESKESHLKFTQDVYSAVVKENSTEA 1995
Query: 184 TSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVV 243
++ +TA +P+ + L Y IL F I + ++ T DRE +E + VV
Sbjct: 1996 ETLAVITAIG--NPI---NEPLFYHILNPDRRFKISRTSGVLSTTGTPFDREQQEAFDVV 2050
Query: 244 IQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQ 303
++ + H + V + D NDN P F Y+ V D +G I V A D+
Sbjct: 2051 VEVTEE--HKPSAVAHVVVKVIVEDQNDNAPVFVNLPYYAVVKVDTEVGHVIRYVTAVDR 2108
Query: 304 DIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFET-KKSYTLKVEAANVHI 362
D G N + Y + + F+I G I L+K + +T K Y + V A +
Sbjct: 2109 DSGRNGEVHYYLKEHHEH--FQI-----GPLGEISLKKQFELDTLNKEYLVTVVAKD--- 2158
Query: 363 DPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITS 422
G F V I V + PVF P Y E+ E+ ++S + V A P+
Sbjct: 2159 ----GGNPAFSAEVIVPITVMNK-AMPVFEKPFYSAEIAESIQVHSPVVHVQANSPE--G 2211
Query: 423 SPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPV 482
+ +SI D QF IN + G I + PLD E + ++I AT+ + + V V
Sbjct: 2212 LKVFYSI-TDGDPFSQFTINFNTGVINVIAPLDFEAHPAYKLSIRATDSLTGAH-AEVFV 2269
Query: 483 AIKVLDVNDNAPEFASE-YEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVN 541
I V D+NDN P FA + Y L E G + V A D D N +
Sbjct: 2270 DIIVDDINDNPPVFAQQSYAVTLSEASVIGTSVVQVRATDSDSEPNRGISYQMFGNHSKS 2329
Query: 542 NPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
+ +F + D+S +++ + ++ + + + D G P LSS +T+ V
Sbjct: 2330 HDHFHV----DSSTGLISLLRTLDYEQSRQHTIFVRAVDGGMPTLSSDVIVTVDV 2380
Score = 73.9 bits (180), Expect = 5e-13
Identities = 89/353 (25%), Positives = 150/353 (42%), Gaps = 43/353 (12%)
Query: 132 YTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGP-------YHATVPEMSILGT 184
Y LT QA D T PP +KV I+ +P+F GP Y A + E + T
Sbjct: 332 YNLTLQAKDKGT-----PPQFSSVKV--IHVTSPQFKAGPVKFEKDVYRAEISEFAPPNT 384
Query: 185 SVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVI 244
V V A P Y + + V+ G+ FS+ T +I P + R+ + + +
Sbjct: 385 PVVMVKAI----PAYSH-LRYVFKSTPGKAKFSLNYNTGLISILEP-VKRQQAAHFELEV 438
Query: 245 QAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQD 304
D +T + V + N NPP+F Q+ Y + E+V +GT + + A D D
Sbjct: 439 TTSDR-------KASTKVLVKVLGANSNPPEFTQTAYKAAFDENVPIGTTVMSLSAVDPD 491
Query: 305 IGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFE-TKKSYTLKVEAANVHID 363
GEN +Y I + L + G + + LD+E + YTL++ A+ D
Sbjct: 492 EGENGYVTYSIAN-----LNHVPFAIDHFTGAVSTSENLDYELMPRVYTLRIRAS----D 542
Query: 364 PRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSS 423
R + AT+ + + D P+F + + + I V+A D D
Sbjct: 543 WGLPYRREVEVLATITLNNLN-DNTPLFEKINCEGTIPRDLGVGEQITTVSAIDAD-ELQ 600
Query: 424 PIRFSIDRHTDLERQFNINADDGKITLATPLDRELSV---WHNITIIATEIRN 473
+++ I+ +L+ F++N + G ++L L L +H++ I AT+ N
Sbjct: 601 LVQYQIEAGNELD-FFSLNPNSGVLSLKRSLMDGLGAKVSFHSLRITATDGEN 652
>gi|13435364 desmocollin 2 isoform Dsc2a preproprotein [Homo
sapiens]
Length = 901
Score = 228 bits (580), Expect = 2e-59
Identities = 217/799 (27%), Positives = 367/799 (45%), Gaps = 90/799 (11%)
Query: 52 EQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAG----T 107
++++L R+KR W +LE GP P+ + ++ +D + I Y + G G
Sbjct: 126 KEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQ-NYTIYYSIRGPGVDQEPRN 184
Query: 108 IFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEF 167
+F + TG+++ + +DRE+ + + A A + P E P IIK++D NDN P F
Sbjct: 185 LFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTP-ELPLPLIIKIEDENDNYPIF 243
Query: 168 LNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP----YFSIEPETA 223
Y T+ E +GT+V V ATD D+P ++ +L YSI+ P FS+ P T
Sbjct: 244 TEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHT-RLKYSIIGQVPPSPTLFSMHPTTG 302
Query: 224 IIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHF 283
+I T +DRE ++Y + I+ +DM G GL T+T + + DVND+ P F ++ Y
Sbjct: 303 VITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVT 362
Query: 284 SVPEDVVLGTAIGRVKANDQDIGENA--QSSYDIIDGDGTALFEITSDAQAQDGIIRLRK 341
SV E+ V I RV D+D+ A +++Y I+ G+ F+I +DA+ +G++ + K
Sbjct: 363 SVEENTV-DVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVK 421
Query: 342 PLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVH 401
PL++E K+ L++ N R + TATV + VED DE P + P + +
Sbjct: 422 PLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMK 481
Query: 402 ENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSV 460
ENA + + A DP+ +SS IR+ + TD I+ + G I + LDRE
Sbjct: 482 ENAEVGTTSNGYKAYDPETRSSSGIRYK--KLTDPTGWVTIDENTGSIKVFRSLDREAET 539
Query: 461 ----WHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQT 516
+NIT++A++ + + + ++ DVNDN+P F + +C KP
Sbjct: 540 IKNGIYNITVLASDQGGRTCTGTLGIILQ--DVNDNSP-FIPKKTVIIC---KPTMSSAE 593
Query: 517 VSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPI 576
+ A+D D+P +G F +SL K +++ + L+ N Y++PI
Sbjct: 594 IVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQND---PPFGSYVVPI 650
Query: 577 IISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMG--ALIAILACIILL 634
+ D +SS ++L + +C C + + V+ + G+ +G A++AIL I LL
Sbjct: 651 TVRD--RLGMSSVTSLDVTLCDCITENDC-THRVDPRIGGGGVQLGKWAILAILLGIALL 707
Query: 635 LVIVVLFVT-LRRHKNEPLIIKDDEDVRENIIRYDDEGGGEEDTEAFDIATLQ----NPD 689
I+ V +P +I DD ++N+I + E G++ + + T Q +
Sbjct: 708 FCILFTLVCGASGTSKQPKVIPDDL-AQQNLIVSNTEAPGDDKVYSANGFTTQTVGASAQ 766
Query: 690 GINGFLPRKDIKPDLQFMPRQGLAPVPNGVDVDE-------------------------- 723
G+ G + ++ ++ + V G E
Sbjct: 767 GVCG-----TVGSGIKNGGQETIEMVKGGHQTSESCRGAGHHHTLDSCRGGHTEVDNCRY 821
Query: 724 -------FINVRLHEA-------DNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDS 769
F RL E +N A Y + Y YEGRGSVAGS+ +
Sbjct: 822 TYSEWHSFTQPRLGEKVYLCNQDENHKHAQDY--VLTYNYEGRGSVAGSVGC--CSERQE 877
Query: 770 DQNFDYLSDWGPRFKRLGE 788
+ ++L + P+F+ L E
Sbjct: 878 EDGLEFLDNLEPKFRTLAE 896
>gi|148539846 desmocollin 3 isoform Dsc3a preproprotein [Homo
sapiens]
Length = 896
Score = 226 bits (577), Expect = 5e-59
Identities = 219/798 (27%), Positives = 356/798 (44%), Gaps = 95/798 (11%)
Query: 53 QRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAG----TI 108
+ +L R+KR W + E GP P+ + ++ +D + + Y +SG G +
Sbjct: 127 ETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGRGVDKEPLNL 185
Query: 109 FQINDVTGDIHAIKRLDREEKAEYTLTAQAVD---WETSKPLEPPSEFIIKVQDINDNAP 165
F I TG++ + +DREE + L A A + PL P I+V+D NDN P
Sbjct: 186 FYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLP----IRVEDENDNHP 241
Query: 166 EFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP----YFSIEPE 221
F Y+ V E S GT+V V ATD D+P ++ +L YSIL+ P FS+ P
Sbjct: 242 VFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSPGLFSVHPS 300
Query: 222 TAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLY 281
T +I T +DRE ++Y ++++ +DM G GL GT+T +T+TD NDN P F Q+ Y
Sbjct: 301 TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY 360
Query: 282 HFSVPEDVVLGTAIGRVKANDQDI--GENAQSSYDIIDGDGTALFEITSDAQAQDGIIRL 339
V E+ I R+ D+D+ N + ++ I+ G+ F+I++D + +G++ +
Sbjct: 361 EAFVEEN-AFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSV 419
Query: 340 RKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLE 399
KPL++E + L++ N R R + A V + V D DE P + +
Sbjct: 420 VKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVR 479
Query: 400 VHENAALNSVIGQVTARDPD-ITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDREL 458
+ EN A+ S I A DP+ + +R+ + D + I+ G I + LDRE+
Sbjct: 480 IKENLAVGSKINGYKAYDPENRNGNGLRYK--KLHDPKGWITIDEISGSIITSKILDREV 537
Query: 459 SV----WHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVI 514
+NIT++A + + S +A+ + DVNDN PE EY +C KP
Sbjct: 538 ETPKNELYNITVLAIDKDDRSCTG--TLAVNIEDVNDNPPEILQEY-VVIC---KPKMGY 591
Query: 515 QTVSAMDKDDPKNGHYFLYSL---LPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEV 571
+ A+D D+P +G F +SL PE+ + T K N+ + K+ GF +
Sbjct: 592 TDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLT-KVNDTAARLSYQKNAGF-----QE 645
Query: 572 YLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACI 631
Y +PI + D ++T L + +C C++ C + + L A++AIL I
Sbjct: 646 YTIPITVKDRAGQ--AATKLLRVNLCECTHP---TQCRATSRSTGVILGKWAILAILLGI 700
Query: 632 ILLLVIVVLFVT----LRRHKNEPLIIKDDEDVRENIIRYDDEGGGEE---DTEAFDIAT 684
LL +++ V + K P ++ ++N+I + E G++ F T
Sbjct: 701 ALLFSVLLTLVCGVFGATKGKRFP-----EDLAQQNLIISNTEAPGDDRVCSANGFMTQT 755
Query: 685 LQNPD----GINGFLPRKDIKPDLQFMP---------------------RQGLAPVPN-- 717
N G G + + ++ M R G V N
Sbjct: 756 TNNSSQGFCGTMGSGMKNGGQETIEMMKGGNQTLESCRGAGHHHTLDSCRGGHTEVDNCR 815
Query: 718 --GVDVDEFINVRLHEA-----DNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSD 770
+ F RL E N+ P D + Y YEGRGS AGS+ + +
Sbjct: 816 YTYSEWHSFTQPRLGEKLHRCNQNEDRMPSQDYVLTYNYEGRGSPAGSVGC--CSEKQEE 873
Query: 771 QNFDYLSDWGPRFKRLGE 788
D+L++ P+F L E
Sbjct: 874 DGLDFLNNLEPKFITLAE 891
>gi|13435366 desmocollin 2 isoform Dsc2b preproprotein [Homo
sapiens]
Length = 847
Score = 223 bits (567), Expect = 7e-58
Identities = 187/642 (29%), Positives = 317/642 (49%), Gaps = 37/642 (5%)
Query: 52 EQRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAG----T 107
++++L R+KR W +LE GP P+ + ++ +D + I Y + G G
Sbjct: 126 KEKVLRRAKRRWAPIPCSMLENSLGPFPLFLQQVQSDTAQ-NYTIYYSIRGPGVDQEPRN 184
Query: 108 IFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEF 167
+F + TG+++ + +DRE+ + + A A + P E P IIK++D NDN P F
Sbjct: 185 LFYVERDTGNLYCTRPVDREQYESFEIIAFATTPDGYTP-ELPLPLIIKIEDENDNYPIF 243
Query: 168 LNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP----YFSIEPETA 223
Y T+ E +GT+V V ATD D+P ++ +L YSI+ P FS+ P T
Sbjct: 244 TEETYTFTIFENCRVGTTVGQVCATDKDEPDTMHT-RLKYSIIGQVPPSPTLFSMHPTTG 302
Query: 224 IIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHF 283
+I T +DRE ++Y + I+ +DM G GL T+T + + DVND+ P F ++ Y
Sbjct: 303 VITTTSSQLDRELIDKYQLKIKVQDMDGQYFGLQTTSTCIINIDDVNDHLPTFTRTSYVT 362
Query: 284 SVPEDVVLGTAIGRVKANDQDIGENA--QSSYDIIDGDGTALFEITSDAQAQDGIIRLRK 341
SV E+ V I RV D+D+ A +++Y I+ G+ F+I +DA+ +G++ + K
Sbjct: 363 SVEENTV-DVEILRVTVEDKDLVNTANWRANYTILKGNENGNFKIVTDAKTNEGVLCVVK 421
Query: 342 PLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVH 401
PL++E K+ L++ N R + TATV + VED DE P + P + +
Sbjct: 422 PLNYEEKQQMILQIGVVNEAPFSREASPRSAMSTATVTVNVEDQDEGPECNPPIQTVRMK 481
Query: 402 ENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSV 460
ENA + + A DP+ +SS IR+ + TD I+ + G I + LDRE
Sbjct: 482 ENAEVGTTSNGYKAYDPETRSSSGIRYK--KLTDPTGWVTIDENTGSIKVFRSLDREAET 539
Query: 461 ----WHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQT 516
+NIT++A++ + + + ++ DVNDN+P F + +C KP
Sbjct: 540 IKNGIYNITVLASDQGGRTCTGTLGIILQ--DVNDNSP-FIPKKTVIIC---KPTMSSAE 593
Query: 517 VSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPI 576
+ A+D D+P +G F +SL K +++ + L+ N Y++PI
Sbjct: 594 IVAVDPDEPIHGPPFDFSLESSTSEVQRMWRLKAINDTAARLSYQND---PPFGSYVVPI 650
Query: 577 IISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMG--ALIAILACIILL 634
+ D +SS ++L + +C C + + V+ + G+ +G A++AIL I LL
Sbjct: 651 TVRD--RLGMSSVTSLDVTLCDCITENDC-THRVDPRIGGGGVQLGKWAILAILLGIALL 707
Query: 635 LVIVVLFVT-LRRHKNEPLIIKDDEDVRENIIRYDDEGGGEE 675
I+ V +P +I DD ++N+I + E G++
Sbjct: 708 FCILFTLVCGASGTSKQPKVIPDDL-AQQNLIVSNTEAPGDD 748
>gi|148539848 desmocollin 3 isoform Dsc3b preproprotein [Homo
sapiens]
Length = 839
Score = 216 bits (550), Expect = 7e-56
Identities = 180/611 (29%), Positives = 294/611 (48%), Gaps = 47/611 (7%)
Query: 53 QRILNRSKRGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAG----TI 108
+ +L R+KR W + E GP P+ + ++ +D + + Y +SG G +
Sbjct: 127 ETVLRRAKRRWAPIPCSMQENSLGPFPLFLQQVESDAAQ-NYTVFYSISGRGVDKEPLNL 185
Query: 109 FQINDVTGDIHAIKRLDREEKAEYTLTAQAVD---WETSKPLEPPSEFIIKVQDINDNAP 165
F I TG++ + +DREE + L A A + PL P I+V+D NDN P
Sbjct: 186 FYIERDTGNLFCTRPVDREEYDVFDLIAYASTADGYSADLPLPLP----IRVEDENDNHP 241
Query: 166 EFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQP----YFSIEPE 221
F Y+ V E S GT+V V ATD D+P ++ +L YSIL+ P FS+ P
Sbjct: 242 VFTEAIYNFEVLESSRPGTTVGVVCATDRDEPDTMHT-RLKYSILQQTPRSPGLFSVHPS 300
Query: 222 TAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLY 281
T +I T +DRE ++Y ++++ +DM G GL GT+T +T+TD NDN P F Q+ Y
Sbjct: 301 TGVITTVSHYLDREVVDKYSLIMKVQDMDGQFFGLIGTSTCIITVTDSNDNAPTFRQNAY 360
Query: 282 HFSVPEDVVLGTAIGRVKANDQDI--GENAQSSYDIIDGDGTALFEITSDAQAQDGIIRL 339
V E+ I R+ D+D+ N + ++ I+ G+ F+I++D + +G++ +
Sbjct: 361 EAFVEEN-AFNVEILRIPIEDKDLINTANWRVNFTILKGNENGHFKISTDKETNEGVLSV 419
Query: 340 RKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLE 399
KPL++E + L++ N R R + A V + V D DE P + +
Sbjct: 420 VKPLNYEENRQVNLEIGVNNEAPFARDIPRVTALNRALVTVHVRDLDEGPECTPAAQYVR 479
Query: 400 VHENAALNSVIGQVTARDPD-ITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDREL 458
+ EN A+ S I A DP+ + +R+ + D + I+ G I + LDRE+
Sbjct: 480 IKENLAVGSKINGYKAYDPENRNGNGLRYK--KLHDPKGWITIDEISGSIITSKILDREV 537
Query: 459 SV----WHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVI 514
+NIT++A + + S +A+ + DVNDN PE EY +C KP
Sbjct: 538 ETPKNELYNITVLAIDKDDRSCTG--TLAVNIEDVNDNPPEILQEY-VVIC---KPKMGY 591
Query: 515 QTVSAMDKDDPKNGHYFLYSL---LPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEV 571
+ A+D D+P +G F +SL PE+ + T K N+ + K+ GF +
Sbjct: 592 TDILAVDPDEPVHGAPFYFSLPNTSPEISRLWSLT-KVNDTAARLSYQKNAGF-----QE 645
Query: 572 YLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMGALIAILACI 631
Y +PI + D ++T L + +C C++ C + + L A++AIL I
Sbjct: 646 YTIPITVKDRAGQ--AATKLLRVNLCECTHP---TQCRATSRSTGVILGKWAILAILLGI 700
Query: 632 ILLLVIVVLFV 642
LL +++ V
Sbjct: 701 ALLFSVLLTLV 711
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 207 bits (527), Expect = 3e-53
Identities = 159/523 (30%), Positives = 252/523 (48%), Gaps = 29/523 (5%)
Query: 96 IKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVD--WETSKPLEPPSEF 153
IKY +S IF IN TG + K LD E ++ +T A+D W
Sbjct: 3124 IKYSISSGNEEGIFAINSSTGILTLAKALDYELCQKHEMTISAIDGGWVARTGY---CSV 3180
Query: 154 IIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQ 213
+ V D+NDN+P FL+ Y TV E + GT+V ++ ATDAD G +A + Y++
Sbjct: 3181 TVNVIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADS---GTNAVIAYTVQSSD 3237
Query: 214 P-YFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDN 272
F I+P T +I T +D E K+ Y + ++A ++ T+ + L N+
Sbjct: 3238 SDLFVIDPNTGVITTQ-GFLDFETKQSYHLTVKAFNVPDEER--CSFATVNIQLKGTNEY 3294
Query: 273 PPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQA 332
P+F LY+F + E GT +G V A+D+D+G + + Y I F+I
Sbjct: 3295 VPRFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINK---- 3350
Query: 333 QDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFS 392
+ G I + LD E ++ +LKV A N S RG D TV + V DA++PP+F+
Sbjct: 3351 KTGQIYVSGILDREKEERVSLKVLAKNFG-----SIRGADIDEVTVNVTVLDANDPPIFT 3405
Query: 393 SPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLER-QFNINADDGKITLA 451
Y +++ E + + + V+A D D S RFS + E F+IN G+IT+
Sbjct: 3406 LNIYSVQISEGVPIGTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVT 3465
Query: 452 TPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPG 511
LDRE +N++++A + S + + + D+NDN P + E + EN +PG
Sbjct: 3466 AELDRETLPIYNLSVLAVDSGTPSATGSASLLVTLEDINDNGP-MLTVSEGEVMENKRPG 3524
Query: 512 QVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEV 571
++ T+ + D D P N F Y LL F++ ++ +L+ +R++
Sbjct: 3525 TLVMTLQSTDPDLPPNQGPFTYYLLSTGPATSYFSL-----STAGVLSTTREIDREQIAD 3579
Query: 572 YLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCNVEAYV 614
+ L ++ DSG P +SST T+ I V ND QS VE +V
Sbjct: 3580 FYLSVVTKDSGVPQMSSTGTVHITVID-QNDNPSQSRTVEIFV 3621
Score = 204 bits (518), Expect = 3e-52
Identities = 160/511 (31%), Positives = 254/511 (49%), Gaps = 33/511 (6%)
Query: 88 DLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPL 147
D D G+ + GA F+I+ +GD+ A +RLDRE +++Y+L +A D S +
Sbjct: 1766 DADEGANALVTYTIISGADDSFRIDPESGDLIATRRLDRERRSKYSLLVRADDGLQSSDM 1825
Query: 148 EPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVY 207
I V D+ND+ P+F Y +PE +I G+ V + ATD D V G +V
Sbjct: 1826 ----RINITVSDVNDHTPKFSRPVYSFDIPEDTIPGSLVAAILATDDDSGVNGEITYIVN 1881
Query: 208 SILEGQPYFSIEPETAIIK-TALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTL 266
E +F + P T + T L +D E ++ Y++ ++A+D GG T + +
Sbjct: 1882 EDDEDGIFF-LNPITGVFNLTRL--LDYEVQQYYILTVRAED----GGGQFTTIRVYFNI 1934
Query: 267 TDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEI 326
DVNDNPP F+ + Y S+ E++ +G+ + D D G N+Q +Y I GD F +
Sbjct: 1935 LDVNDNPPIFSLNSYSTSLMENLPVGSTVLVFNVTDADDGINSQLTYSIASGDSLGQFTV 1994
Query: 327 TSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDA- 385
++G++++ K LD E++ Y L V+ VH P+ F TA V I++ D
Sbjct: 1995 D-----KNGVLKVLKALDRESQSFYNLVVQ---VHDLPQIPA-SRFTSTAQVSIILLDVN 2045
Query: 386 DEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINAD 444
D PP F SP L + EN +++V+ + A DPD +S I +++ L +F+I
Sbjct: 2046 DNPPTFLSPK-LTYIPENTPIDTVVFKAQATDPDSGPNSYIEYTL--LNPLGNKFSIGTI 2102
Query: 445 DGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASE-YEAF 503
DG++ L LDRE + +T++AT+ S S V + VLD+NDN P FA Y+
Sbjct: 2103 DGEVRLTGELDREEVSNYTLTVVATDKGQPSLSSSTEVVVMVLDINDNNPIFAQALYKVE 2162
Query: 504 LCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNG 563
+ EN G I V A D D+ NG Y ++ N N + D+ +
Sbjct: 2163 INENTLTGTDIIQVFAADGDEGTNGQ-VRYGIV-----NGNTNQEFRIDSVTGAITVAKP 2216
Query: 564 FNRQKQEVYLLPIIISDSGNPPLSSTSTLTI 594
+R+K Y L + +D G+ P + TST++I
Sbjct: 2217 LDREKTPTYHLTVQATDRGSTPRTDTSTVSI 2247
Score = 191 bits (484), Expect = 3e-48
Identities = 163/573 (28%), Positives = 273/573 (47%), Gaps = 50/573 (8%)
Query: 77 PEPILVGR-----LHTDLDPGSKK-IKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKA 130
PE +VG D D G+ I+Y L +G T FQ++ TG I + LD E +
Sbjct: 260 PEDAVVGSSVLQVAAADADEGTNADIRYRLQDEG--TPFQMDPETGLITVREPLDFEARR 317
Query: 131 EYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPE-----FLNGPYHATVPEMSILGTS 185
+Y+LT QA+D L +E +I++ D+NDN P F +A+V E + +GT
Sbjct: 318 QYSLTVQAMDRGVPS-LTGRAEALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTV 376
Query: 186 VTNVTATDADDPVYGNSAKLVYSILEG--QPYFSIE----PETAIIKTALPNMDREAKEE 239
V +T TDAD P + + IL G Q +F ++ P ++IK A +DRE
Sbjct: 377 VALLTVTDADSPAANGNISV--QILGGNEQRHFEVQSSKVPNLSLIKVASA-LDRERIPS 433
Query: 240 YLVVIQAKDMGGHSGGL-----SGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTA 294
Y + + D G G S +L + + D+ND+PP F+Q +Y ++ E+ G+
Sbjct: 434 YNLTVSVSDNYGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSY 493
Query: 295 IGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKP--LDFETKKSYT 352
+ + A D D G NA Y I+ G+G F I+ + G++ LD E
Sbjct: 494 VSGISATDGDSGLNANLRYSIVSGNGLGWFHISEHS----GLVTTGSSGGLDRELASQIV 549
Query: 353 LKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPT-YLLEVHENAALNSVIG 411
L + A + + P+ S V +++ DE PVFS P Y + V ENA + +
Sbjct: 550 LNISARDQGVHPKVSY------AQLVVTLLDVNDEKPVFSQPEGYDVSVVENAPTGTELL 603
Query: 412 QVTARDPDI-TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATE 470
+ A D D+ + +RFS+ R F ++ G+++ + LDRE ++++ ++AT+
Sbjct: 604 MLRATDGDLGDNGTVRFSLQEAETDRRSFRLDPVSGRLSTISSLDREEQAFYSLLVLATD 663
Query: 471 IRNHSQISRVPVAIKVLDVNDNAPEF-ASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGH 529
+ + Q S + + +LD+NDN+P F +Y A + EN G I TVSA D D NG
Sbjct: 664 LGSPPQSSMARINVSLLDINDNSPVFYPVQYFAHIKENEPGGSYITTVSATDPDLGTNG- 722
Query: 530 YFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSST 589
YS+ + F + +++ +R+++ Y L I+ +D GN +
Sbjct: 723 TVKYSI--SAGDRSRFQVNAQS----GVISTRMALDREEKTAYQLQIVATDGGNLQSPNQ 776
Query: 590 STLTIRVCGCSNDGVVQSCNVEAYVLPIGLSMG 622
+ +TI V ++ V S ++V+ +++G
Sbjct: 777 AIVTITVLDTQDNPPVFSQVAYSFVVFENVALG 809
Score = 186 bits (473), Expect = 6e-47
Identities = 148/509 (29%), Positives = 247/509 (48%), Gaps = 42/509 (8%)
Query: 106 GTIFQINDVTGDIHAIKRLDREEKA-EYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNA 164
G +F I TG I LDRE+ A Y + A++ T+ P +E I +QDINDN
Sbjct: 1678 GRLFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNP 1737
Query: 165 PEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEG-QPYFSIEPETA 223
P F TV E G+ + +TA DAD+ G +A + Y+I+ G F I+PE+
Sbjct: 1738 PVFPTDMLDLTVEENIGDGSKIMQLTAMDADE---GANALVTYTIISGADDSFRIDPESG 1794
Query: 224 IIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHF 283
+ A +DRE + +Y ++++A D G S + +T++DVND+ PKF++ +Y F
Sbjct: 1795 DL-IATRRLDRERRSKYSLLVRADD-----GLQSSDMRINITVSDVNDHTPKFSRPVYSF 1848
Query: 284 SVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPL 343
+PED + G+ + + A D D G N + +Y + + D +F + G+ L + L
Sbjct: 1849 DIPEDTIPGSLVAAILATDDDSGVNGEITYIVNEDDEDGIFFLNPIT----GVFNLTRLL 1904
Query: 344 DFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHEN 403
D+E ++ Y L V A + G G F +++ D PP+FS +Y + EN
Sbjct: 1905 DYEVQQYYILTVRAED--------GGGQFTTIRVYFNILDVNDNPPIFSLNSYSTSLMEN 1956
Query: 404 AALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWH 462
+ S + D D +S + +SI L QF ++ +G + + LDRE ++
Sbjct: 1957 LPVGSTVLVFNVTDADDGINSQLTYSIASGDSL-GQFTVD-KNGVLKVLKALDRESQSFY 2014
Query: 463 NITIIATEIRNHSQI------SRVPVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQT 516
N+ + ++ + QI S V+I +LDVNDN P F S ++ EN V+
Sbjct: 2015 NLVV---QVHDLPQIPASRFTSTAQVSIILLDVNDNPPTFLSPKLTYIPENTPIDTVVFK 2071
Query: 517 VSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPI 576
A D D N Y Y+LL + N F+I D + + + +R++ Y L +
Sbjct: 2072 AQATDPDSGPNS-YIEYTLLNPLGN--KFSI-GTIDGEVRLTGE---LDREEVSNYTLTV 2124
Query: 577 IISDSGNPPLSSTSTLTIRVCGCSNDGVV 605
+ +D G P LSS++ + + V +++ +
Sbjct: 2125 VATDKGQPSLSSSTEVVVMVLDINDNNPI 2153
Score = 184 bits (466), Expect = 4e-46
Identities = 153/509 (30%), Positives = 236/509 (46%), Gaps = 50/509 (9%)
Query: 109 FQINDVTGDIHAIKRLDREE------KAEYTLTAQAVDWETSKPLEPPSEFIIKVQDIND 162
F+++ ++G+I + DRE A ++ T A D +PL+ + + ++DIND
Sbjct: 1146 FELHAISGEITNTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDIND 1205
Query: 163 NAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEG--QPYFSIEP 220
NAP+FL Y AT+ E + T V V+A+D D+ GN+ + YSI++G + F+I+
Sbjct: 1206 NAPKFLKDFYQATISESAANLTQVLRVSASDVDE---GNNGLIHYSIIKGNEERQFAIDS 1262
Query: 221 ETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSL 280
+ + T + +D EA Y +VIQA D G + L+ T TL + + D NDN P F +S
Sbjct: 1263 TSGQV-TLIGKLDYEATPAYSLVIQAVDSG--TIPLNSTCTLNIDILDENDNTPSFPKST 1319
Query: 281 YHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLR 340
V E++ +G + V A D D G+NA Y I + F I+ + G I L
Sbjct: 1320 LFVDVLENMRIGELVSSVTATDSDSGDNADLYYSITGTNNHGTFSISPNT----GSIFLA 1375
Query: 341 KPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVED-ADEPPVFSSPTYLLE 399
K LDFET+ Y L + A + GR P T +V I V D D PP F
Sbjct: 1376 KKLDFETQSLYKLNITAKD-------QGRPPRSSTMSVVIHVRDFNDNPPSFPPGDIFKS 1428
Query: 400 VHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDREL 458
+ EN + + + VTA DPD + + ++I + F I+ G I +DRE
Sbjct: 1429 IVENIPIGTSVISVTAHDPDADINGQLSYTIIQQMPRGNHFTIDEVKGTIYTNAEIDREF 1488
Query: 459 SVWHNITIIATEIRNHSQISRVP---VAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQ 515
+ +T+ A + + R V I V D+NDN P F S+ + G V+
Sbjct: 1489 ANLFELTVKANDQAVPIETRRYALKNVTILVTDLNDNVPMFISQNALAADPSAVIGSVLT 1548
Query: 516 TVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNR------QKQ 569
T+ A D D+ NG Y ++ N D I+ +++G R Q
Sbjct: 1549 TIMAADPDEGANGE-IEYEII-------------NGDTDTFIVDRYSGDLRVASALVPSQ 1594
Query: 570 EVYLLPIIISDSGNPPLSSTSTLTIRVCG 598
+Y L + +D G ST+ LTI + G
Sbjct: 1595 LIYNLIVSATDLGPERRKSTTELTIILQG 1623
Score = 182 bits (462), Expect = 1e-45
Identities = 170/523 (32%), Positives = 252/523 (48%), Gaps = 48/523 (9%)
Query: 87 TDLDPG-SKKIKY-ILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETS 144
TD D G + ++ Y I SGD G F + D G + +K LDRE ++ Y L Q D
Sbjct: 1969 TDADDGINSQLTYSIASGDSLGQ-FTV-DKNGVLKVLKALDRESQSFYNLVVQVHDL--- 2023
Query: 145 KPLEPPSEFIIKVQ------DINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPV 198
P P S F Q D+NDN P FL+ P +PE + + T V ATD D
Sbjct: 2024 -PQIPASRFTSTAQVSIILLDVNDNPPTFLS-PKLTYIPENTPIDTVVFKAQATDPDS-- 2079
Query: 199 YGNSAKLVYSILEGQPY-FSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLS 257
G ++ + Y++L FSI ++ +DRE Y + + A D G S LS
Sbjct: 2080 -GPNSYIEYTLLNPLGNKFSIGTIDGEVRLT-GELDREEVSNYTLTVVATDKGQPS--LS 2135
Query: 258 GTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIID 317
+T + V + D+NDN P FAQ+LY + E+ + GT I +V A D D G N Q Y I++
Sbjct: 2136 SSTEVVVMVLDINDNNPIFAQALYKVEINENTLTGTDIIQVFAADGDEGTNGQVRYGIVN 2195
Query: 318 GDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTAT 377
G+ F I S G I + KPLD E +Y L V+A + G P DT+T
Sbjct: 2196 GNTNQEFRIDS----VTGAITVAKPLDREKTPTYHLTVQATD-------RGSTPRTDTST 2244
Query: 378 VKIVVEDA-DEPPVFSSPTYLLEVHEN-AALNSVIGQVTARDPDITSSPIRFSIDRHTDL 435
V IV+ D D PVF Y + V EN L I QV ARD D S+ + +
Sbjct: 2245 VSIVLLDINDFVPVFELSPYSVNVPENLGTLPRTILQVVARDDDRGSNSKLSYVLFGGNE 2304
Query: 436 ERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPE 495
+ F ++A G++ + LDRE + I AT+ + + + + V DVNDN P
Sbjct: 2305 DNAFTLSA-SGELGVTQSLDRETKERFVLMITATDSGSPALTGTGTINVIVDDVNDNVPT 2363
Query: 496 FASE-YEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNS 554
FAS+ Y + E+ G + V+A D D KN +++ + N FTI +
Sbjct: 2364 FASKAYFTTIPEDAPTGTDVLLVNASDADASKN------AVIRIIGGNSQFTINPSTGQI 2417
Query: 555 LSILAKHNGFNRQKQEVYLLPIIISDSGNP-PLSSTSTLTIRV 596
++ +R+ ++ Y L ++ SD+G+P PLSS++++ + V
Sbjct: 2418 ITSAL----LDRETKDNYTLVVVCSDAGSPEPLSSSTSVLVTV 2456
Score = 178 bits (452), Expect = 2e-44
Identities = 162/519 (31%), Positives = 246/519 (47%), Gaps = 51/519 (9%)
Query: 88 DLDPGSK-KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKP 146
D D GS K+ Y+L G F ++ +G++ + LDRE K + L A D S
Sbjct: 2286 DDDRGSNSKLSYVLFGGNEDNAFTLS-ASGELGVTQSLDRETKERFVLMITATD-SGSPA 2343
Query: 147 LEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLV 206
L + V D+NDN P F + Y T+PE + GT V V A+DAD S V
Sbjct: 2344 LTGTGTINVIVDDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADA-----SKNAV 2398
Query: 207 YSILEGQPYFSIEPETA-IIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVT 265
I+ G F+I P T II +AL +DRE K+ Y +V+ D G LS +T++ VT
Sbjct: 2399 IRIIGGNSQFTINPSTGQIITSAL--LDRETKDNYTLVVVCSDAGSPEP-LSSSTSVLVT 2455
Query: 266 LTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFE 325
+TDVNDNPP+F Y +P + G+ + V D DIG N++ Y + G + F
Sbjct: 2456 VTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSL-SGRNSEKFH 2514
Query: 326 ITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKI-VVED 384
I G I PL+ ++ ++++ V+ G P D+ TV + V
Sbjct: 2515 I----DPLRGAIMAAGPLNGASEVTFSVHVKDG---------GSFPKTDSTTVTVRFVNK 2561
Query: 385 ADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINAD 444
AD P V + + EN ++S++ +T + P+ + I +L F I+
Sbjct: 2562 ADFPKVRAKEQTFM-FPENQPVSSLVTTITGSS--LRGEPMSYYI-ASGNLGNTFQIDQL 2617
Query: 445 DGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASE-YEAF 503
G+++++ PLD E + + I A + S + I VLDVNDNAP F + + +
Sbjct: 2618 TGQVSISQPLDFEKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPIFKEDPFISE 2677
Query: 504 LCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSI------ 557
+ EN P +++ TVSAMDKD NG L E+VN N +NS SI
Sbjct: 2678 ILENLSPRKIL-TVSAMDKDSGPNGQ-----LDYEIVNG-------NMENSFSINHATGE 2724
Query: 558 LAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
+ +R+K Y+L I SD G+P S++ + I +
Sbjct: 2725 IRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINI 2763
Score = 170 bits (430), Expect = 5e-42
Identities = 153/490 (31%), Positives = 225/490 (45%), Gaps = 37/490 (7%)
Query: 109 FQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFL 168
F+++ V+G + I LDREE+A Y+L A D S P + + + DINDN+P F
Sbjct: 632 FRLDPVSGRLSTISSLDREEQAFYSLLVLATDLG-SPPQSSMARINVSLLDINDNSPVFY 690
Query: 169 NGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEG-QPYFSIEPETAIIKT 227
Y A + E G+ +T V+ATD D G + + YSI G + F + ++ +I T
Sbjct: 691 PVQYFAHIKENEPGGSYITTVSATDPD---LGTNGTVKYSISAGDRSRFQVNAQSGVIST 747
Query: 228 ALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPE 287
+ +DRE K Y + I A D G +T+T+ D DNPP F+Q Y F V E
Sbjct: 748 RMA-LDREEKTAYQLQIVATDGGNLQS--PNQAIVTITVLDTQDNPPVFSQVAYSFVVFE 804
Query: 288 DVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFET 347
+V LG +G V A+ D+ N+ SY I GD +F I G + +D E
Sbjct: 805 NVALGYHVGSVSASTMDL--NSNISYLITTGDQKGMFAINQ----VTGQLTTANVIDREE 858
Query: 348 KKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDA-DEPPVFSSPTYLLEVHENAAL 406
+ Y LKV A+ G V I V+D D P F + V EN
Sbjct: 859 QSFYQLKVVASG----------GTVTGDTMVNITVKDLNDNSPHFLQAIESVNVVENWQA 908
Query: 407 NSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNIT 465
I Q A DPD + + +S+ ++ + F IN +G I+L PLD + I
Sbjct: 909 GHSIFQAKAVDPDEGVNGMVLYSLKQNP--KNLFAINEKNGTISLLGPLDVHAGS-YQIE 965
Query: 466 IIATEIRNHSQISRVPVAIKVLDVNDNAPEFAS-EYEAFLCENGKPGQVIQTVSAMDKDD 524
I+A+++ S V + + V DVNDN+P F YE L E+ V A DKD
Sbjct: 966 ILASDMGVPQLSSSVILTVYVHDVNDNSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDS 1025
Query: 525 PKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNP 584
NG Y++ N D L I ++ +R+ Q+ Y+L ++ SD
Sbjct: 1026 GANGE-IAYTIAE---GNTGDAFGIFPDGQLYIKSE---LDRELQDRYVLMVVASDRAVE 1078
Query: 585 PLSSTSTLTI 594
PLS+T +T+
Sbjct: 1079 PLSATVNVTV 1088
Score = 167 bits (422), Expect = 5e-41
Identities = 151/523 (28%), Positives = 240/523 (45%), Gaps = 59/523 (11%)
Query: 93 SKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSE 152
+ I Y+++ +F IN VTG + +DREE++ Y L A + + +
Sbjct: 823 NSNISYLITTGDQKGMFAINQVTGQLTTANVIDREEQSFYQLKVVA----SGGTVTGDTM 878
Query: 153 FIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEG 212
I V+D+NDN+P FL V E G S+ A D D+ V G ++YS+ +
Sbjct: 879 VNITVKDLNDNSPHFLQAIESVNVVENWQAGHSIFQAKAVDPDEGVNG---MVLYSLKQN 935
Query: 213 -QPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVND 271
+ F+I + I P +D A Y + I A DMG LS + LTV + DVND
Sbjct: 936 PKNLFAINEKNGTISLLGP-LDVHAGS-YQIEILASDMGVPQ--LSSSVILTVYVHDVND 991
Query: 272 NPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQ 331
N P F Q Y ++ E + + +V+A+D+D G N + +Y I +G+ F I D Q
Sbjct: 992 NSPVFDQLSYEVTLSESEPVNSRFFKVQASDKDSGANGEIAYTIAEGNTGDAFGIFPDGQ 1051
Query: 332 AQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDA-DEPPV 390
+ ++ LD E + Y L V A++ ++ P T V +++ED D P+
Sbjct: 1052 -----LYIKSELDRELQDRYVLMVVASDRAVE-------PLSATVNVTVILEDVNDNRPL 1099
Query: 391 FSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINADDGKIT 449
F+S Y E S +G+V+A D D + +R+S + ++ F ++A G+IT
Sbjct: 1100 FNSTNYTFYFEEEQRAGSFVGKVSAVDKDFGPNGEVRYSFEM---VQPDFELHAISGEIT 1156
Query: 450 LATPLDREL------SVWHNITIIATEIRNHSQI-SRVPVAIKVLDVNDNAPEFASE-YE 501
DRE + + T+IAT+ + + V + + D+NDNAP+F + Y+
Sbjct: 1157 NTHQFDRESLMRRRGTAVFSFTVIATDQGIPQPLKDQATVHVYMKDINDNAPKFLKDFYQ 1216
Query: 502 AFLCENGKPGQVIQTVSAMDKDDPKNG--HYFLYSLLPEMVNNPNFTIKKNEDNSLSI-- 557
A + E+ + VSA D D+ NG HY + IK NE+ +I
Sbjct: 1217 ATISESAANLTQVLRVSASDVDEGNNGLIHYSI--------------IKGNEERQFAIDS 1262
Query: 558 ----LAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
+ + + Y L I DSG PL+ST TL I +
Sbjct: 1263 TSGQVTLIGKLDYEATPAYSLVIQAVDSGTIPLNSTCTLNIDI 1305
Score = 167 bits (422), Expect = 5e-41
Identities = 139/465 (29%), Positives = 231/465 (49%), Gaps = 26/465 (5%)
Query: 70 VLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEK 129
+LE S + + V + D P + I++G+ + F IN TG+I +++ LDRE+
Sbjct: 2678 ILENLSPRKILTVSAMDKDSGPNGQLDYEIVNGNMENS-FSINHATGEIRSVRPLDREKV 2736
Query: 130 AEYTLTAQAVDWETSKPLEPPS-EFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTN 188
+ Y LT ++ D P + S + +I + D NDNAP F + + A VPE S LG +VT
Sbjct: 2737 SHYVLTIKSSD--KGSPSQSTSVKVMINILDENDNAPRF-SQIFSAHVPENSPLGYTVTR 2793
Query: 189 VTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKD 248
VT +D D G +A YSI++ F+I P T I + P ++RE + Y + + A
Sbjct: 2794 VTTSDED---IGINAISRYSIMDASLPFTINPSTGDIVISRP-LNREDTDRYRIRVSA-- 2847
Query: 249 MGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGEN 308
H G + +T +T+ +TD+NDN P+F+++ Y+ PE +G+ + +V A D D G N
Sbjct: 2848 ---HDSGWTVSTDVTIFVTDINDNAPRFSRTSYYLDCPELTEIGSKVTQVFATDPDEGSN 2904
Query: 309 AQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYT-LKVEAANVHIDPRFS 367
Q Y I + F I A G I ++ L ++ ++ + + + +
Sbjct: 2905 GQVFYFI--KSQSEYFRI----NATTGEIFNKQILKYQNVTGFSNVNINRHSFIVTSSDR 2958
Query: 368 GRGPFKDTATVKI-VVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI--TSSP 424
G+ TV I +V+ D P F Y V +N + + + +VTA D +S
Sbjct: 2959 GKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKDFGLNSE 3018
Query: 425 IRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAI 484
+ + I L + F ++ D G I++A+ L +L+ IT+ A + N S+ V I
Sbjct: 3019 VEYFISNDNHLGK-FKLDNDTGWISVASSLISDLNQNFFITVTAKDKGNPPLSSQATVHI 3077
Query: 485 KVLDVNDNAPEFA-SEYEAFLCENGKPGQVIQTVSAMDKDDPKNG 528
V + N + PEF+ S A + E+ G +++TVSA D+D NG
Sbjct: 3078 TVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNG 3122
Score = 157 bits (398), Expect = 3e-38
Identities = 159/564 (28%), Positives = 257/564 (45%), Gaps = 57/564 (10%)
Query: 70 VLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEK 129
VLEE P LVG + T PG Y LS A +F IN TG ++ +DRE
Sbjct: 51 VLEE--QPPGTLVGTIQTR--PG---FTYRLSESHA--LFAINSSTGALYTTSTIDRESL 101
Query: 130 AEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNV 189
+ + +S P P +E + V+D+NDNAP F + T E S G V
Sbjct: 102 PSDVINLVVL---SSAPTYP-TEVRVLVRDLNDNAPVFPDPSIVVTFKEDSSSGRQVILD 157
Query: 190 TATDADDPVYGNSAKLVYSILEGQPY------FSIEP--ETAIIK-TALPNMDREAKEEY 240
TATD+D G + Y I+ G ++ P E A + + +DRE +Y
Sbjct: 158 TATDSDIGSNGVDHRS-YRIIRGNEAGRFRLDITLNPSGEGAFLHLVSKGGLDREVTPQY 216
Query: 241 LVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKA 300
++++ +D G G + VT+ D+NDNPP F S Y VPED V+G+++ +V A
Sbjct: 217 QLLVEVEDKGEPKR--RGYLQVNVTVQDINDNPPVFGSSHYQAGVPEDAVVGSSVLQVAA 274
Query: 301 NDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANV 360
D D G NA Y + D +GT + G+I +R+PLDFE ++ Y+L V+A +
Sbjct: 275 ADADEGTNADIRYRLQD-EGTPF-----QMDPETGLITVREPLDFEARRQYSLTVQAMDR 328
Query: 361 HIDPRFSGRGPFKDTATVKIVVEDADEPPV----FSSPTYLLEVHENAALNSVIGQVTAR 416
+ P +GR A ++++ + ++P V F + + V ENA + +V+ +T
Sbjct: 329 GV-PSLTGRA----EALIQLLDVNDNDPVVKFRYFPATSRYASVDENAQVGTVVALLTVT 383
Query: 417 DPDITSSPIRFSID-RHTDLERQFNINADD----GKITLATPLDRELSVWHNITIIATE- 470
D D ++ S+ + +R F + + I +A+ LDRE +N+T+ ++
Sbjct: 384 DADSPAANGNISVQILGGNEQRHFEVQSSKVPNLSLIKVASALDRERIPSYNLTVSVSDN 443
Query: 471 ------IRNHSQISRVPVAIKVLDVNDNAPEFASE-YEAFLCENGKPGQVIQTVSAMDKD 523
++ S + I V D+ND+ P F+ + Y L E PG + +SA D D
Sbjct: 444 YGAPPGAAVQARSSVASLVIFVNDINDHPPVFSQQVYRVNLSEEAPPGSYVSGISATDGD 503
Query: 524 DPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGN 583
N + YS++ N +E + L G +R+ +L I D G
Sbjct: 504 SGLNAN-LRYSIVS---GNGLGWFHISEHSGLVTTGSSGGLDRELASQIVLNISARDQGV 559
Query: 584 PPLSSTSTLTIRVCGCSNDGVVQS 607
P S + L + + +++ V S
Sbjct: 560 HPKVSYAQLVVTLLDVNDEKPVFS 583
Score = 154 bits (389), Expect = 3e-37
Identities = 146/512 (28%), Positives = 227/512 (44%), Gaps = 43/512 (8%)
Query: 75 SGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTL 134
+G + +LV +D D + I+ G+ F IN TG I LDRE K YTL
Sbjct: 2379 TGTDVLLVNA--SDADASKNAVIRIIGGNSQ---FTINPSTGQIITSALLDRETKDNYTL 2433
Query: 135 TAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDA 194
D + +PL + ++ V D+NDN P F + PY +P ++ G+ V VT TDA
Sbjct: 2434 VVVCSDAGSPEPLSSSTSVLVTVTDVNDNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDA 2493
Query: 195 DDPVYGNSAKLVYSIL-EGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHS 253
D G +++L YS+ F I+P I A P E + KD
Sbjct: 2494 D---IGPNSELHYSLSGRNSEKFHIDPLRGAIMAAGP---LNGASEVTFSVHVKD----G 2543
Query: 254 GGLSGTTTLTVTLTDVND-NPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSS 312
G T + TVT+ VN + PK F PE+ + + + + + S
Sbjct: 2544 GSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMFPENQPVSSLVTTITGSSL---RGEPMS 2600
Query: 313 YDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPF 372
Y I G+ F+I G + + +PLDFE + Y + +EA R G PF
Sbjct: 2601 YYIASGNLGNTFQI----DQLTGQVSISQPLDFEKIQKYVVWIEA-------RDGGFPPF 2649
Query: 373 KDTATVKIVVEDA-DEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSID 430
+ I V D D P+F ++ E+ EN + ++ V+A D D + + + I
Sbjct: 2650 SSYEKLDITVLDVNDNAPIFKEDPFISEILENLSPRKIL-TVSAMDKDSGPNGQLDYEI- 2707
Query: 431 RHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVN 490
+ ++E F+IN G+I PLDRE + +TI +++ + SQ + V V I +LD N
Sbjct: 2708 VNGNMENSFSINHATGEIRSVRPLDREKVSHYVLTIKSSDKGSPSQSTSVKVMINILDEN 2767
Query: 491 DNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKN 550
DNAP F+ + A + EN G + V+ D+D N YS++ + FTI
Sbjct: 2768 DNAPRFSQIFSAHVPENSPLGYTVTRVTTSDEDIGINA-ISRYSIMDASL---PFTI--- 2820
Query: 551 EDNSLSILAKHNGFNRQKQEVYLLPIIISDSG 582
+ S + NR+ + Y + + DSG
Sbjct: 2821 -NPSTGDIVISRPLNREDTDRYRIRVSAHDSG 2851
Score = 148 bits (374), Expect = 2e-35
Identities = 145/521 (27%), Positives = 218/521 (41%), Gaps = 35/521 (6%)
Query: 88 DLDPGSK-KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKP 146
D D G+ +++Y + F+I+ VTG I K LDRE+ Y LT QA D S P
Sbjct: 2180 DGDEGTNGQVRYGIVNGNTNQEFRIDSVTGAITVAKPLDREKTPTYHLTVQATD-RGSTP 2238
Query: 147 LEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLV 206
S I + DIND P F PY VPE LGT + A D G+++KL
Sbjct: 2239 RTDTSTVSIVLLDINDFVPVFELSPYSVNVPEN--LGTLPRTILQVVARDDDRGSNSKLS 2296
Query: 207 YSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTL 266
Y + G + + ++DRE KE ++++I A D G S L+GT T+ V +
Sbjct: 2297 YVLFGGNEDNAFTLSASGELGVTQSLDRETKERFVLMITATDSG--SPALTGTGTINVIV 2354
Query: 267 TDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEI 326
DVNDN P FA Y ++PED GT + V A+D D +NA II G+ F I
Sbjct: 2355 DDVNDNVPTFASKAYFTTIPEDAPTGTDVLLVNASDADASKNAVIR--IIGGNSQ--FTI 2410
Query: 327 TSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDA- 385
G I LD ETK +YTL V ++ P + +V + V D
Sbjct: 2411 NPST----GQIITSALLDRETKDNYTLVVVCSDA------GSPEPLSSSTSVLVTVTDVN 2460
Query: 386 DEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINAD 444
D PP F Y+ + S + VT D DI +S + +S+ +F+I+
Sbjct: 2461 DNPPRFQHHPYVTHIPSPTLPGSFVFAVTVTDADIGPNSELHYSLSGRNS--EKFHIDPL 2518
Query: 445 DGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEFASEYEAFL 504
G I A PL+ V ++ + + + + V ++ ++ D A E
Sbjct: 2519 RGAIMAAGPLNGASEVTFSVHV--KDGGSFPKTDSTTVTVRFVNKADFPKVRAKEQTFMF 2576
Query: 505 CENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGF 564
EN ++ T++ +Y L T + + L
Sbjct: 2577 PENQPVSSLVTTITGSSLRGEPMSYYIASGNLGNTFQIDQLTGQVSISQPLDF------- 2629
Query: 565 NRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVV 605
+K + Y++ I D G PP SS L I V +++ +
Sbjct: 2630 --EKIQKYVVWIEARDGGFPPFSSYEKLDITVLDVNDNAPI 2668
Score = 140 bits (354), Expect = 4e-33
Identities = 141/537 (26%), Positives = 246/537 (45%), Gaps = 47/537 (8%)
Query: 87 TDLDPGSK-KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTL------TAQAV 139
TD D GS ++ Y + F+IN TG+I + L + ++ +
Sbjct: 2897 TDPDEGSNGQVFYFIKSQSE--YFRINATTGEIFNKQILKYQNVTGFSNVNINRHSFIVT 2954
Query: 140 DWETSKP-LEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPV 198
+ KP L + I + D NDNAP+FL Y V + +GT + VTA D D
Sbjct: 2955 SSDRGKPSLISETTVTINIVDSNDNAPQFLKSKYFTPVTKNVKVGTKLIRVTAIDDKD-- 3012
Query: 199 YGNSAKLVYSILEGQPY--FSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGL 256
+G ++++ Y I F ++ +T I A ++ + + + + + AKD G L
Sbjct: 3013 FGLNSEVEYFISNDNHLGKFKLDNDTGWISVA-SSLISDLNQNFFITVTAKDKGNPP--L 3069
Query: 257 SGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDII 316
S T+ +T+T+ N + P+F+QS ++PE +G+ + V A D+D N Y I
Sbjct: 3070 SSQATVHITVTEENYHTPEFSQSHMSATIPESHSIGSIVRTVSARDRDAAMNGLIKYSIS 3129
Query: 317 DGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTA 376
G+ +F I S GI+ L K LD+E + + + + A ID + R + +
Sbjct: 3130 SGNEEGIFAINSST----GILTLAKALDYELCQKHEMTISA----IDGGWVARTGY-CSV 3180
Query: 377 TVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSI-DRHTD 434
TV V++ D PVF S Y V ENA + + + A D D T++ I +++ +D
Sbjct: 3181 TVN-VIDVNDNSPVFLSDDYFPTVLENAPSGTTVIHLNATDADSGTNAVIAYTVQSSDSD 3239
Query: 435 LERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAP 494
L F I+ + G IT LD E +++T+ A + + + S V I++ N+ P
Sbjct: 3240 L---FVIDPNTGVITTQGFLDFETKQSYHLTVKAFNVPDEERCSFATVNIQLKGTNEYVP 3296
Query: 495 EFASEYEAF-LCENGKPGQVIQTVSAMDKDDPKNG--HYFLYSLLPE---MVNNPNFTI- 547
F S+ F + E G ++ V A D+D +G HY ++ + +N I
Sbjct: 3297 RFVSKLYYFEISEAAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIY 3356
Query: 548 -------KKNEDNSLSILAKHNGFNRQKQ-EVYLLPIIISDSGNPPLSSTSTLTIRV 596
+K E SL +LAK+ G R + + + + D+ +PP+ + + ++++
Sbjct: 3357 VSGILDREKEERVSLKVLAKNFGSIRGADIDEVTVNVTVLDANDPPIFTLNIYSVQI 3413
Score = 135 bits (341), Expect = 1e-31
Identities = 148/560 (26%), Positives = 242/560 (43%), Gaps = 54/560 (9%)
Query: 87 TDLDPGSKK-IKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSK 145
TD D G + Y ++G F I+ TG I K+LD E ++ Y L A D +
Sbjct: 1340 TDSDSGDNADLYYSITGTNNHGTFSISPNTGSIFLAKKLDFETQSLYKLNITAKD-QGRP 1398
Query: 146 PLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKL 205
P +I V+D NDN P F G ++ E +GTSV +VTA D D + G +L
Sbjct: 1399 PRSSTMSVVIHVRDFNDNPPSFPPGDIFKSIVENIPIGTSVISVTAHDPDADING---QL 1455
Query: 206 VYSILEGQP---YFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMG-GHSGGLSGTTT 261
Y+I++ P +F+I+ I T +DRE + + ++A D
Sbjct: 1456 SYTIIQQMPRGNHFTIDEVKGTIYTN-AEIDREFANLFELTVKANDQAVPIETRRYALKN 1514
Query: 262 LTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGT 321
+T+ +TD+NDN P F S + V+G+ + + A D D G N + Y+II+GD
Sbjct: 1515 VTILVTDLNDNVPMFI-SQNALAADPSAVIGSVLTTIMAADPDEGANGEIEYEIINGDTD 1573
Query: 322 ALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIV 381
T G +R+ L ++ Y L V A ++ + R K T + I+
Sbjct: 1574 -----TFIVDRYSGDLRVASAL-VPSQLIYNLIVSATDLGPERR-------KSTTELTII 1620
Query: 382 VEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSI----DRHTDLER 437
++ D PVF+ P Y+ + E + + + + A P + +P+ + I + R
Sbjct: 1621 LQGLD-GPVFTQPKYITILKEGEPIGTNVISIEAASPRGSEAPVEYYIVSVRCEEKTVGR 1679
Query: 438 QFNINADDGKITLATPLDREL-SVWHNITIIATEIRN-HSQISRVPVAIKVLDVNDNAPE 495
F I G I A LDRE + + + + A E + R V I + D+NDN P
Sbjct: 1680 LFTIGRHTGIIQTAAILDREQGACLYLVDVYAIEKSTAFPRTQRAEVEITLQDINDNPPV 1739
Query: 496 FASE-YEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNS 554
F ++ + + EN G I ++AMD D+ N +TI D+S
Sbjct: 1740 FPTDMLDLTVEENIGDGSKIMQLTAMDADEGANALV-------------TYTIISGADDS 1786
Query: 555 LSI------LAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSC 608
I L +R+++ Y L ++ +D G SS + I V ++ S
Sbjct: 1787 FRIDPESGDLIATRRLDRERRSKYSL-LVRADDGLQ--SSDMRINITVSDVNDHTPKFSR 1843
Query: 609 NVEAYVLPIGLSMGALIAIL 628
V ++ +P G+L+A +
Sbjct: 1844 PVYSFDIPEDTIPGSLVAAI 1863
Score = 97.1 bits (240), Expect = 6e-20
Identities = 99/356 (27%), Positives = 163/356 (45%), Gaps = 26/356 (7%)
Query: 75 SGPEPILVGRLH-TDLDPGSK-KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEY 132
+ P+ +VG + +D D G+ ++ Y++ G+ FQIN TG I+ LDRE++
Sbjct: 3310 AAPKGTIVGEVFASDRDLGTDGEVHYLIFGNSRKKGFQINKKTGQIYVSGILDREKEERV 3369
Query: 133 TLTAQAVDWETSKPLEPPSEFI-IKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTA 191
+L A ++ + + + + + V D ND P F Y + E +GT VT V+A
Sbjct: 3370 SLKVLAKNFGSIRGADIDEVTVNVTVLDAND-PPIFTLNIYSVQISEGVPIGTHVTFVSA 3428
Query: 192 TDADD-PVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMG 250
D+D P + + + S E FSI P+T I T +DRE Y + + A D G
Sbjct: 3429 FDSDSIPSWSRFSYFIGSGNENGA-FSINPQTGQI-TVTAELDRETLPIYNLSVLAVDSG 3486
Query: 251 GHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQ 310
S +G+ +L VTL D+NDN P S V E+ GT + +++ D D+ N
Sbjct: 3487 TPSA--TGSASLLVTLEDINDNGPMLTVS--EGEVMENKRPGTLVMTLQSTDPDLPPNQG 3542
Query: 311 --SSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSG 368
+ Y + G T+ F +++ G++ + +D E + L V + SG
Sbjct: 3543 PFTYYLLSTGPATSYFSLSTA-----GVLSTTREIDREQIADFYLSVVTKD-------SG 3590
Query: 369 RGPFKDTATVKIVVEDADEPPVFSSPTYL-LEVHENAALNSVIGQVTARDPDITSS 423
T TV I V D ++ P S + + + N ++G V +DPD+ S
Sbjct: 3591 VPQMSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLDS 3646
Score = 80.1 bits (196), Expect = 7e-15
Identities = 75/264 (28%), Positives = 109/264 (41%), Gaps = 18/264 (6%)
Query: 76 GPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLT 135
G V +D P + Y + F IN TG I LDRE Y L+
Sbjct: 3420 GTHVTFVSAFDSDSIPSWSRFSYFIGSGNENGAFSINPQTGQITVTAELDRETLPIYNLS 3479
Query: 136 AQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDAD 195
AVD T S ++ ++DINDN P V E GT V + +TD D
Sbjct: 3480 VLAVDSGTPSATGSAS-LLVTLEDINDNGPMLTVS--EGEVMENKRPGTLVMTLQSTDPD 3536
Query: 196 DPVYGNSAKLVYSILEGQP---YFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGH 252
P N Y +L P YFS+ TA + + +DRE ++ + + KD G
Sbjct: 3537 LP--PNQGPFTYYLLSTGPATSYFSL--STAGVLSTTREIDREQIADFYLSVVTKDSGVP 3592
Query: 253 SGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSS 312
+S T T+ +T+ D NDNP + + ++ G +G VK D D+ ++ S
Sbjct: 3593 Q--MSSTGTVHITVIDQNDNPSQSRTVEIFVNYYGNLFPGGILGSVKPQDPDVLDSFHCS 3650
Query: 313 YDIIDGDGTALFEI---TSDAQAQ 333
+ T+LF I T D +Q
Sbjct: 3651 ---LTSGVTSLFSIPGGTCDLNSQ 3671
>gi|145309304 cadherin EGF LAG seven-pass G-type receptor 3 [Homo
sapiens]
Length = 3312
Score = 207 bits (527), Expect = 3e-53
Identities = 172/547 (31%), Positives = 269/547 (49%), Gaps = 45/547 (8%)
Query: 77 PEPILVGRLHTDLDPGSKKIKY--ILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTL 134
P +++ TD D + + + I+SG+ G F I+ +TG+I + LD E + EY L
Sbjct: 560 PHTVVLRVTATDRDKDANGLVHYNIISGNSRGH-FAIDSLTGEIQVVAPLDFEAEREYAL 618
Query: 135 TAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDA 194
+A D I+V DIND+ P F++ P+ +V E + LG SV ++ A DA
Sbjct: 619 RIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDA 678
Query: 195 DDPVYGNSAKLVYSILEGQPY--FSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGH 252
D +G +A+L YS+ P F I T + + P +DRE+ E Y ++A+D G
Sbjct: 679 D---HGENARLEYSLTGVAPDTPFVINSATGWVSVSGP-LDRESVEHYFFGVEARDHG-- 732
Query: 253 SGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSS 312
S LS + ++TVT+ DVNDN P+F YH + ED +GT++ V A D+D N+ S
Sbjct: 733 SPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRDA--NSAIS 790
Query: 313 YDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPF 372
Y I G+ F I++ Q G++ L PLD++ ++ + L + A++ +
Sbjct: 791 YQITGGNTRNRFAIST--QGGVGLVTLALPLDYKQERYFKLVLTASDRALH--------- 839
Query: 373 KDTATVKIVVEDAD-EPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSID 430
D V I + DA+ PVF S Y + V+E+ + S I ++A D D+ ++ I + ++
Sbjct: 840 -DHCYVHINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLLE 898
Query: 431 RHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVN 490
D QF I+AD G ITL PLD E V + + I A + + V + V DVN
Sbjct: 899 ---DNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVN 955
Query: 491 DNAPEF-ASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKK 549
DNAP+F AS Y + E+ P + +SA D+D NG Y+ + +FTI+
Sbjct: 956 DNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGR-VQYTFQNGEDGDGDFTIEP 1014
Query: 550 NEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCSNDGVVQSCN 609
I+ +R+ VY L D G PPL + ++ + +VQ N
Sbjct: 1015 TS----GIVRTVRRLDREAVSVYELTAYAVDRGVPPLRTPVSIQV---------MVQDVN 1061
Query: 610 VEAYVLP 616
A V P
Sbjct: 1062 DNAPVFP 1068
Score = 180 bits (457), Expect = 4e-45
Identities = 160/523 (30%), Positives = 250/523 (47%), Gaps = 54/523 (10%)
Query: 88 DLDPGSK-KIKYILSGDGAGTIFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKP 146
D D G +++Y L+G T F IN TG + LDRE Y +A D S P
Sbjct: 677 DADHGENARLEYSLTGVAPDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARD-HGSPP 735
Query: 147 LEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLV 206
L + + V D+NDN PEF YH + E + +GTSV +VTA D D NSA +
Sbjct: 736 LSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD----ANSA-IS 790
Query: 207 YSILEGQPY----FSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTL 262
Y I G S + ++ ALP +D + + + +V+ A D H +
Sbjct: 791 YQITGGNTRNRFAISTQGGVGLVTLALP-LDYKQERYFKLVLTASDRALHDH-----CYV 844
Query: 263 TVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTA 322
+ +TD N + P F + Y SV ED +G+ I + A+D D+GENA+ +Y + D
Sbjct: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENARITYLL--EDNLP 902
Query: 323 LFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVV 382
F I +D+ G I L+ PLD+E + +YTL + A R +G DT V+++V
Sbjct: 903 QFRIDADS----GAITLQAPLDYEDQVTYTLAITA-------RDNGIPQKADTTYVEVMV 951
Query: 383 EDA-DEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFN 440
D D P F + Y V E+A + + Q++A D D + ++++ D + F
Sbjct: 952 NDVNDNAPQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFT 1011
Query: 441 INADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVL--DVNDNAPEF-A 497
I G + LDRE + +T A + R + R PV+I+V+ DVNDNAP F A
Sbjct: 1012 IEPTSGIVRTVRRLDREAVSVYELTAYAVD-RGVPPL-RTPVSIQVMVQDVNDNAPVFPA 1069
Query: 498 SEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSL----LPEMVNNPNFTIKKNEDN 553
E+E + EN G V+ ++A+D D+ N H +Y + +PE+ F+
Sbjct: 1070 EEFEVRVKENSIVGSVVAQITAVDPDEGPNAH-IMYQIVEGNIPELFQMDIFS------G 1122
Query: 554 SLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
L+ L + RQ+ +I+ + + PL S +T+ +R+
Sbjct: 1123 ELTALIDLDYEARQEY------VIVVQATSAPLVSRATVHVRL 1159
Score = 168 bits (426), Expect = 2e-41
Identities = 139/429 (32%), Positives = 207/429 (48%), Gaps = 32/429 (7%)
Query: 108 IFQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEF 167
+F I+ +G I LDRE + L A D S L + + V D ND++P F
Sbjct: 375 LFSIDPQSGLIRTAAALDRESMERHYLRVTAQD-HGSPRLSATTMVAVTVADRNDHSPVF 433
Query: 168 LNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPY--------FSIE 219
Y T+ E G + + ATD D P +A L Y + G P F I+
Sbjct: 434 EQAQYRETLRENVEEGYPILQLRATDGDAPP---NANLRYRFV-GPPAARAAAAAAFEID 489
Query: 220 PETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQS 279
P + +I T+ +DRE E Y +V++A D G G S T + +T+ D NDN P+F++
Sbjct: 490 PRSGLISTS-GRVDREHMESYELVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEK 548
Query: 280 LYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRL 339
Y V EDV T + RV A D+D N Y+II G+ F I S G I++
Sbjct: 549 RYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDS----LTGEIQV 604
Query: 340 RKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLE 399
PLDFE ++ Y L++ A + P + G A+++ VV+ D P+F S + +
Sbjct: 605 VAPLDFEAEREYALRIRAQDAGRPPLSNNTG----LASIQ-VVDINDHIPIFVSTPFQVS 659
Query: 400 VHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDREL 458
V ENA L + + A D D ++ + +S+ + F IN+ G ++++ PLDRE
Sbjct: 660 VLENAPLGHSVIHIQAVDADHGENARLEYSLTGVAP-DTPFVINSATGWVSVSGPLDRE- 717
Query: 459 SVWHNITIIATEIRNHSQ---ISRVPVAIKVLDVNDNAPEFA-SEYEAFLCENGKPGQVI 514
SV H E R+H + V + VLDVNDN PEF EY L E+ G +
Sbjct: 718 SVEH--YFFGVEARDHGSPPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSV 775
Query: 515 QTVSAMDKD 523
+V+A+D+D
Sbjct: 776 VSVTAVDRD 784
Score = 156 bits (394), Expect = 8e-38
Identities = 159/530 (30%), Positives = 236/530 (44%), Gaps = 41/530 (7%)
Query: 79 PILVGRLHTDLDPGSKKIKYILSGD-----GAGTIFQINDVTGDIHAIKRLDREEKAEYT 133
PIL R P + ++Y G A F+I+ +G I R+DRE Y
Sbjct: 451 PILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEIDPRSGLISTSGRVDREHMESYE 510
Query: 134 LTAQAVD-WETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTAT 192
L +A D + P I V D NDNAP+F Y A V E T V VTAT
Sbjct: 511 LVVEASDQGQEPGPRSATVRVHITVLDENDNAPQFSEKRYVAQVREDVRPHTVVLRVTAT 570
Query: 193 DADDPVYGNSAKLVYSILEG--QPYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMG 250
D D G + Y+I+ G + +F+I+ T I+ P +D EA+ EY + I+A+D G
Sbjct: 571 DRDKDANG---LVHYNIISGNSRGHFAIDSLTGEIQVVAP-LDFEAEREYALRIRAQDAG 626
Query: 251 GHSGGLSGTTTL-TVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENA 309
LS T L ++ + D+ND+ P F + + SV E+ LG ++ ++A D D GENA
Sbjct: 627 --RPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAPLGHSVIHIQAVDADHGENA 684
Query: 310 QSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGR 369
+ Y + F I S G + + PLD E+ + Y VEA R G
Sbjct: 685 RLEYSLTGVAPDTPFVINS----ATGWVSVSGPLDRESVEHYFFGVEA-------RDHGS 733
Query: 370 GPFKDTATVKIVVEDA-DEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFS 428
P +A+V + V D D P F+ Y L ++E+AA+ + + VTA D D +S I +
Sbjct: 734 PPLSASASVTVTVLDVNDNRPEFTMKEYHLRLNEDAAVGTSVVSVTAVDRD-ANSAISYQ 792
Query: 429 IDRHTDLER-QFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVL 487
I R + G +TLA PLD + + + + A++ H V I +
Sbjct: 793 ITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASDRALHDHCY---VHINIT 849
Query: 488 DVNDNAPEFAS-EYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFT 546
D N + P F S Y + E+ G I +SA D D +N + LL + N P F
Sbjct: 850 DANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDDVGENAR--ITYLLED--NLPQFR 905
Query: 547 IKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
I D + + + Q Y L I D+G P + T+ + + V
Sbjct: 906 I----DADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMV 951
Score = 154 bits (389), Expect = 3e-37
Identities = 132/447 (29%), Positives = 219/447 (48%), Gaps = 38/447 (8%)
Query: 165 PEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSIL-----EGQPYFSIE 219
P+F Y VPE GT+V V A DP G + +LVYS+ FSI+
Sbjct: 323 PQFPQYNYQTLVPENEAAGTAVLRVV---AQDPDAGEAGRLVYSLAALMNSRSLELFSID 379
Query: 220 PETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQS 279
P++ +I+TA +DRE+ E + + + A+D G S LS TT + VT+ D ND+ P F Q+
Sbjct: 380 PQSGLIRTAAA-LDRESMERHYLRVTAQDHG--SPRLSATTMVAVTVADRNDHSPVFEQA 436
Query: 280 LYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDIID-----GDGTALFEITSDAQAQD 334
Y ++ E+V G I +++A D D NA Y + A FEI +
Sbjct: 437 QYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGPPAARAAAAAAFEI----DPRS 492
Query: 335 GIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKI---VVEDADEPPVF 391
G+I +D E +SY L VEA++ G+ P +ATV++ V+++ D P F
Sbjct: 493 GLISTSGRVDREHMESYELVVEASD-------QGQEPGPRSATVRVHITVLDENDNAPQF 545
Query: 392 SSPTYLLEVHENAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLA 451
S Y+ +V E+ ++V+ +VTA D D ++ + + F I++ G+I +
Sbjct: 546 SEKRYVAQVREDVRPHTVVLRVTATDRDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVV 605
Query: 452 TPLDRELSVWHNITIIATEIRNHSQISRVPVA-IKVLDVNDNAPEFAS-EYEAFLCENGK 509
PLD E + + I A + + +A I+V+D+ND+ P F S ++ + EN
Sbjct: 606 APLDFEAEREYALRIRAQDAGRPPLSNNTGLASIQVVDINDHIPIFVSTPFQVSVLENAP 665
Query: 510 PGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSILAKHNGFNRQKQ 569
G + + A+D D +N YSL + P F I +++ ++ +R+
Sbjct: 666 LGHSVIHIQAVDADHGENAR-LEYSLTGVAPDTP-FVI----NSATGWVSVSGPLDRESV 719
Query: 570 EVYLLPIIISDSGNPPLSSTSTLTIRV 596
E Y + D G+PPLS+++++T+ V
Sbjct: 720 EHYFFGVEARDHGSPPLSASASVTVTV 746
Score = 133 bits (335), Expect = 6e-31
Identities = 120/440 (27%), Positives = 201/440 (45%), Gaps = 39/440 (8%)
Query: 96 IKYILSGDGAGTIFQINDV--TGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEF 153
I Y ++G F I+ G + LD +++ + L A D + L
Sbjct: 789 ISYQITGGNTRNRFAISTQGGVGLVTLALPLDYKQERYFKLVLTASD----RALHDHCYV 844
Query: 154 IIKVQDINDNAPEFLNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQ 213
I + D N + P F + Y +V E +G+++ ++A+D D G +A++ Y + +
Sbjct: 845 HINITDANTHRPVFQSAHYSVSVNEDRPMGSTIVVISASDDD---VGENARITYLLEDNL 901
Query: 214 PYFSIEPETAIIKTALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNP 273
P F I+ ++ I P +D E + Y + I A+D G + TT + V + DVNDN
Sbjct: 902 PQFRIDADSGAITLQAP-LDYEDQVTYTLAITARDNGIPQK--ADTTYVEVMVNDVNDNA 958
Query: 274 PKFAQSLYHFSVPEDVVLGTAIGRVKANDQDIGENAQSSYDII---DGDGTALFEITSDA 330
P+F S Y V ED T++ ++ A D+D N + Y DGDG E TS
Sbjct: 959 PQFVASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTS-- 1016
Query: 331 QAQDGIIRLRKPLDFETKKSYTLKVEAANVHIDPRFSGRGPFKDTATVKIVVEDA-DEPP 389
GI+R + LD E Y L A + G P + +++++V+D D P
Sbjct: 1017 ----GIVRTVRRLDREAVSVYELTAYAVD-------RGVPPLRTPVSIQVMVQDVNDNAP 1065
Query: 390 VFSSPTYLLEVHENAALNSVIGQVTARDPDI-TSSPIRFSIDRHTDLERQFNINADDGKI 448
VF + + + V EN+ + SV+ Q+TA DPD ++ I + I ++ F ++ G++
Sbjct: 1066 VFPAEEFEVRVKENSIVGSVVAQITAVDPDEGPNAHIMYQIVEG-NIPELFQMDIFSGEL 1124
Query: 449 TLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAP---EFASEYEAFLC 505
T LD E + I + AT +SR V ++++D NDN+P F + ++
Sbjct: 1125 TALIDLDYEARQEYVIVVQATSA---PLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVS 1181
Query: 506 ENGK--PGQVIQTVSAMDKD 523
P +I + A D D
Sbjct: 1182 NRSDTFPSGIIGRIPAYDPD 1201
Score = 128 bits (322), Expect = 2e-29
Identities = 102/368 (27%), Positives = 177/368 (48%), Gaps = 27/368 (7%)
Query: 109 FQINDVTGDIHAIKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFI-IKVQDINDNAPEF 167
F+I+ +G I LD E++ YTL A D P + + ++ + V D+NDNAP+F
Sbjct: 904 FRIDADSGAITLQAPLDYEDQVTYTLAITARD--NGIPQKADTTYVEVMVNDVNDNAPQF 961
Query: 168 LNGPYHATVPEMSILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKT 227
+ Y V E + TSV ++ATD D G + +G F+IEP + I++T
Sbjct: 962 VASHYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRT 1021
Query: 228 ALPNMDREAKEEYLVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPE 287
+ +DREA Y + A D G L ++ V + DVNDN P F + V E
Sbjct: 1022 -VRRLDREAVSVYELTAYAVDRGVPP--LRTPVSIQVMVQDVNDNAPVFPAEEFEVRVKE 1078
Query: 288 DVVLGTAIGRVKANDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFET 347
+ ++G+ + ++ A D D G NA Y I++G+ LF++ + +I LD+E
Sbjct: 1079 NSIVGSVVAQITAVDPDEGPNAHIMYQIVEGNIPELFQMDIFSGELTALI----DLDYEA 1134
Query: 348 KKSYTLKVEAANVHIDPRFSGRGPFKDTATVKI-VVEDADEPPVFSSPTYLLEVH----E 402
++ Y + V+A + P ATV + +V+ D PV ++ L +
Sbjct: 1135 RQEYVIVVQATS----------APLVSRATVHVRLVDQNDNSPVLNNFQILFNNYVSNRS 1184
Query: 403 NAALNSVIGQVTARDPDITSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWH 462
+ + +IG++ A DPD+ S + +S +R +L+ +N G++ L+ LD +
Sbjct: 1185 DTFPSGIIGRIPAYDPDV-SDHLFYSFERGNELQ-LLVVNQTSGELRLSRKLDNNRPLVA 1242
Query: 463 NITIIATE 470
++ + T+
Sbjct: 1243 SMLVTVTD 1250
Score = 62.8 bits (151), Expect = 1e-09
Identities = 57/219 (26%), Positives = 91/219 (41%), Gaps = 11/219 (5%)
Query: 385 ADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPD------ITSSPIRFSIDRHTDLERQ 438
A+ P F Y V EN A + + +V A+DPD + S R +L
Sbjct: 319 ANRHPQFPQYNYQTLVPENEAAGTAVLRVVAQDPDAGEAGRLVYSLAALMNSRSLEL--- 375
Query: 439 FNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRVPVAIKVLDVNDNAPEF-A 497
F+I+ G I A LDRE H + + A + + + VA+ V D ND++P F
Sbjct: 376 FSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRNDHSPVFEQ 435
Query: 498 SEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMVNNPNFTIKKNEDNSLSI 557
++Y L EN + G I + A D D P N + Y + D +
Sbjct: 436 AQYRETLRENVEEGYPILQLRATDGDAPPNAN-LRYRFVGPPAARAAAAAAFEIDPRSGL 494
Query: 558 LAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRV 596
++ +R+ E Y L + SD G P ++T+ + +
Sbjct: 495 ISTSGRVDREHMESYELVVEASDQGQEPGPRSATVRVHI 533
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.135 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,534,008
Number of Sequences: 37866
Number of extensions: 1469767
Number of successful extensions: 8342
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 202
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 2447
Number of HSP's gapped (non-prelim): 942
length of query: 799
length of database: 18,247,518
effective HSP length: 110
effective length of query: 689
effective length of database: 14,082,258
effective search space: 9702675762
effective search space used: 9702675762
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.