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Search of human proteins with 157785668
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|157785668 coiled-coil domain containing 39 [Homo sapiens]
(941 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157785668 coiled-coil domain containing 39 [Homo sapiens] 1806 0.0
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 142 1e-33
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 142 1e-33
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 142 1e-33
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 142 1e-33
gi|71061468 centromere protein E [Homo sapiens] 141 3e-33
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 136 8e-32
gi|55770834 centromere protein F [Homo sapiens] 136 8e-32
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 136 1e-31
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 129 1e-29
gi|38044112 restin isoform b [Homo sapiens] 128 3e-29
gi|4506751 restin isoform a [Homo sapiens] 128 3e-29
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 128 3e-29
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 125 1e-28
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 125 1e-28
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 125 2e-28
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 124 4e-28
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 124 4e-28
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 124 5e-28
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 122 2e-27
gi|156104908 myosin heavy chain 6 [Homo sapiens] 120 8e-27
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 120 8e-27
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 119 2e-26
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 119 2e-26
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 118 3e-26
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 117 7e-26
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 116 9e-26
gi|118498356 kinectin 1 isoform a [Homo sapiens] 115 3e-25
gi|33620775 kinectin 1 isoform a [Homo sapiens] 115 3e-25
gi|58530840 desmoplakin isoform I [Homo sapiens] 114 3e-25
>gi|157785668 coiled-coil domain containing 39 [Homo sapiens]
Length = 941
Score = 1806 bits (4677), Expect = 0.0
Identities = 941/941 (100%), Positives = 941/941 (100%)
Query: 1 MSSEFLAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFK 60
MSSEFLAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFK
Sbjct: 1 MSSEFLAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFK 60
Query: 61 NVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKEN 120
NVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKEN
Sbjct: 61 NVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKEN 120
Query: 121 GIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLER 180
GIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLER
Sbjct: 121 GIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLER 180
Query: 181 LTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGD 240
LTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGD
Sbjct: 181 LTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGD 240
Query: 241 IDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDH 300
IDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDH
Sbjct: 241 IDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDH 300
Query: 301 ETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKL 360
ETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKL
Sbjct: 301 ETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKL 360
Query: 361 KEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVL 420
KEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVL
Sbjct: 361 KEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVL 420
Query: 421 SEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQAL 480
SEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQAL
Sbjct: 421 SEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQAL 480
Query: 481 EAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFI 540
EAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFI
Sbjct: 481 EAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFI 540
Query: 541 DRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERT 600
DRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERT
Sbjct: 541 DRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERT 600
Query: 601 EEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQ 660
EEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQ
Sbjct: 601 EEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQ 660
Query: 661 AYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSS 720
AYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSS
Sbjct: 661 AYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSS 720
Query: 721 DEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQA 780
DEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQA
Sbjct: 721 DEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQA 780
Query: 781 YSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDE 840
YSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDE
Sbjct: 781 YSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDE 840
Query: 841 MLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTS 900
MLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTS
Sbjct: 841 MLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTS 900
Query: 901 QSSIKVLELKFPASSSLVGSPSRPSSASSSSSNVKSKKSSK 941
QSSIKVLELKFPASSSLVGSPSRPSSASSSSSNVKSKKSSK
Sbjct: 901 QSSIKVLELKFPASSSLVGSPSRPSSASSSSSNVKSKKSSK 941
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 142 bits (358), Expect = 1e-33
Identities = 186/869 (21%), Positives = 383/869 (44%), Gaps = 115/869 (13%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETE 81
EE + ED+L K K+ + ++EL+E E++ + +T KN+ QE + + E
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQE-----------QLQAE 899
Query: 82 SEEHFKAIAQR-ELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQ 140
+E + +A R L K E++ + +EM + LE++ D+ Q+L + +M
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-------GQQLQAERKKMAQQM 952
Query: 141 QALEAWLEESAHKDSDALTLQKY-AQQDDNKIRALTLQLERLTLECNQKRKILDNELTET 199
LE LEE L L+K A+ K+ L ++ + +++RK+L+ +++
Sbjct: 953 LDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 200 ISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKR-----------DGD-------I 241
+ E ++ A++ K+ N+ + +I + E +++ +K +GD I
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 242 DNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHE 301
+ ++A +K + +KE ++ + L+ EI K+I ++ E
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI--------------RELE 1117
Query: 302 TSRIQLKGELDSLKATVNRTSSDLEALRKNISKIK---KDIHEETARLQKTKNHNEIIQT 358
L+ +LDS +A N+ L + + +K +D + TA Q+ + E T
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 359 KLKE-ITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEK 417
LK+ + E+T S E +++M ++ + V+E+ QL K + QT +
Sbjct: 1178 VLKKALDEETRSHE---AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234
Query: 418 AVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMS---RLKGEINS 474
+ E+ + + + H+ +KL+ + +Q+++ + S R + E+N
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQ--------------VQELQSKCSDGERARAELN- 1279
Query: 475 EEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKIN 534
++ L+ ++ + L E + L + L + L ++ + + +K ++ TK+
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 535 ELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYT 594
+L + + +LD+ KQ+L + L +++ +++ L A V +LE+ K++
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399
Query: 595 AMEERT---EEIKVHKTMLASQIRYVDQERENISTEF---RERLSKIEKLKNRYEILTVV 648
+E T EE L + QE +++ + R+ +S +EK + +++ L
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL-- 1457
Query: 649 MLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQV---LNSC 705
EE+ + Y A E++ + E K KA ALE L+ L
Sbjct: 1458 -----AEEKNISSKY----ADERDRAEAEA---REKETKALSLARALEEALEAKEELERT 1505
Query: 706 NNNYKQSFKKVTPSSDEYELKI-QLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVI 764
N K + + S D+ + +LE+ KRA++ + + Q+ EL++++Q+ E+ +
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 765 E--------HLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLK-D 815
E +++ + + + QL ++ E + +LE KQ A + L+ D
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 816 TKD-ETMEEQDIKLRE--MKQFHKVIDEM 841
KD E + IK RE +KQ K+ +M
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Score = 129 bits (323), Expect = 2e-29
Identities = 183/903 (20%), Positives = 383/903 (42%), Gaps = 153/903 (16%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
L+ Q+++LK + A ++EL+ R++ + N +++ + + + +SE
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAW 146
+ A+++ + +E++ L+ E+ L+ + ++ K Q++ LK ++ + ++ EA
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193
Query: 147 LEESAHKDSDALT-----LQKY----AQQDDNKIRALTLQLERLTL------------EC 185
++E K + A+ L+++ A D NK TL+ E L E
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK---QTLEKENADLAGELRVLGQAKQEV 1250
Query: 186 NQKRKILDNELTETISAQLELDKAAQDFR-KIHNERQELIKQWENTIEQMQKRDGDIDNC 244
K+K L+ ++ E S + ++A + K+H + E+ E+ + + +G
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV----ESVTGMLNEAEGKAIKL 1306
Query: 245 ALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSR 304
A ++A + + ++ + L++E+ T + +S R+L + R + QD
Sbjct: 1307 AKDVASLSSQLQDTQELLQEE-----------TRQKLNVSTKLRQLEEERNSLQDQLDEE 1355
Query: 305 IQLKGELDSLKATVNRTSSD-----------LEALRKNISKIKKDI------HEETA--- 344
++ K L+ +T+N SD +EAL + + +K+I +EE A
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 345 -RLQKTKNHNEIIQTKLKEIT-------EKTMSVEEKATNLEDMLKEE---------EKD 387
+L+KTKN +Q +L ++ + ++E+K + +L EE E+D
Sbjct: 1416 DKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 388 VKEVDVQLNLIKGVLFKKAQELQTETMKE--------KAVLSEIEGTRSSLKHLNHQLQK 439
E + + K + +A E E +E KA + ++ ++ + H+L+K
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532
Query: 440 ------LDFETLKQQ------EIMYSQDFHIQQVERRMSRLKGEI----------NSEEK 477
E +K Q E+ ++D ++ +E M LKG+ N E++
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKR 1591
Query: 478 QALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELN 537
+ L+ ++ E LE+++ L KKL DL ++ ++ + ++ +L
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1651
Query: 538 LFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAME 597
+ ++EL+ A+ + ++ + + K L E++ + E+ ++Q E
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Query: 598 ERTEEIKVH---KTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILT--VVMLPP 652
E EE+ + L + R ++ + E E +E + +R T L
Sbjct: 1712 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771
Query: 653 EGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQS 712
E E++ A K +++L+R+ L +K+++ E + K
Sbjct: 1772 ELATERSTAQ---KNESARQQLERQNKELRSKLHEMEGAV-----------------KSK 1811
Query: 713 FKKVTPSSDEYELKI-QLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEH---LA 768
FK + E KI QLEEQ V+++ R KQ + L++ + ++ L +E +A
Sbjct: 1812 FKSTIAA---LEAKIAQLEEQ---VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865
Query: 769 NNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKL 828
KE+ + A QL ++ EE + + +R+ KL +E+ DE E +
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL-------DEATESNEAMG 1918
Query: 829 REM 831
RE+
Sbjct: 1919 REV 1921
Score = 118 bits (296), Expect = 2e-26
Identities = 199/930 (21%), Positives = 400/930 (43%), Gaps = 145/930 (15%)
Query: 20 ANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERE 79
A + K LED++ + D+ L E + EERI+ +T+ N+ +E ++L K + +
Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT---NLAEEEEKAKNLTKLKNK- 1031
Query: 80 TESEEHFKAIAQRELGRVKDEIQRLENEMASILEKK-----SDKENGIFKATQKLDGLKC 134
H I++ E+ K+E R E E L++K SD I ++ LK
Sbjct: 1032 -----HESMISELEVRLKKEEKSRQELEK---LKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 135 QMNWDQQALEAWL----EESAHKDSDALTLQKYA------QQDDNKIRALTLQLERLTLE 184
Q+ ++ L+A L +E A K++ +++ Q+D + RA + E+ +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 185 CNQKRKILDNELTETISA---QLELD-KAAQDFRKIHNERQELIKQWENTIEQMQKRDGD 240
++ + L EL +T+ + Q EL K Q+ + E + E +++M+++
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 241 IDNCALELARIKQETREKENLVKEKIKFLESEIGN-----------NTEFEKRISVADRK 289
E +++Q R K NL K K + LE E + E E + + +
Sbjct: 1204 AVEELTE--QLEQFKRAKANLDKNK-QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 290 LLKCRTAYQDHETSRIQL-------KGELDSLKATVNRTSSDLEALRKNISKIKKDIHEE 342
+ + ++ D E +R +L + E++S+ +N L K+++ + + +
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 343 TARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVL 402
LQ+ + TKL+++ E+ S++++ + + E+ + +++QL+ K L
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 403 ----------------FKKAQELQTETMKEK-AVLSEIEGTRSSLKHLNHQLQKLDFETL 445
F+K E T+ +EK A ++E T++ L +L L +
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN---RLQQELDDLVVDLD 1437
Query: 446 KQQEIMYSQDFHIQQVERRMSRLKGE---INSE----------EKQALEAKIVELRKSLE 492
Q++++ ++++ +R+ +L E I+S+ E + E K + L ++LE
Sbjct: 1438 NQRQLV----SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 493 EKKSTCGLLETQIKKLH---NDLYFIKKAHSKNSDE----KQSLMTKINELNLFIDRSEK 545
E LE K L DL K KN E K++L T++ E+ ++ E
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 546 ELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQ---QLYTAMEERTEE 602
EL + K L +E N+ L+ + R++ +A + + EKR+Q QL+ E E+
Sbjct: 1554 ELQATEDAK--LRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH-EYETELED 1607
Query: 603 IKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAY 662
+ + + A+ + ++ + +++ L +K R E + + K QA
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDL------ELQADSAIKGREEAIK--------QLRKLQA- 1652
Query: 663 YVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDE 722
+ +E E+ + D + A + EK+ +LE L L +++ K+ +E
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712
Query: 723 Y--ELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIE---HLANNVKEKLSE 777
EL L + DEK R + R I +L+E+++ + ++ + A E+LS
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEAR-IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771
Query: 778 KQAYSFQLSKETEEQKPKLERVTKQ-------------------CAKLTKEIRLLKDTKD 818
+ A +++ E + +LER K+ A L +I L++ +
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831
Query: 819 ETMEEQDIKLREMKQFHKVIDEMLVDIIEE 848
+ E+ + +KQ K + E+L+ + +E
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Score = 96.7 bits (239), Expect = 9e-20
Identities = 147/772 (19%), Positives = 321/772 (41%), Gaps = 133/772 (17%)
Query: 148 EESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELD 207
EE K+ + ++ Q+ +N+++ L + +LT E N L E + A+ EL
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE--------KNLLQEQLQAETELY 903
Query: 208 KAAQDFR-KIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKI 266
A++ R ++ ++QEL E + +M+ AR+++E + L E+
Sbjct: 904 AEAEEMRVRLAAKKQEL----EEILHEME-------------ARLEEEEDRGQQLQAERK 946
Query: 267 KFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLE 326
K + + + E+ + + L+ TA E +L+ E+ + N+ S + +
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTA----EAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 327 ALRKNISKIKKDIHEETAR---LQKTKNHNEI----IQTKLKEITEKTMSVEEKATNLED 379
L + IS + ++ EE + L K KN +E ++ +LK+ + +E+ LE
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1062
Query: 380 MLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQK 439
+ + + ++ Q+ +K L KK +ELQ + +++ ++ L +
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 440 LDFETLKQQEIMYSQDFHIQQVERRMSRLKGEI-----NSEEKQALEAK----IVELRKS 490
L + ++ + + + + LK E+ ++ +Q L AK + L+K+
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 491 LEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKA 550
L+E+ + E Q++++ ++ H++ +E + + +D++++ L+K
Sbjct: 1183 LDEETRSH---EAQVQEM-------RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 551 KGFKQDLMIEDNLL---KLEVKRTREMLHSKAEEVLSL----EKRKQQLYTAMEERTEEI 603
DL E +L K EV+ ++ L ++ +E+ S E+ + +L + + E+
Sbjct: 1233 NA---DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 604 KVHKTML--------------ASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVM 649
+ ML AS + +E + E R++L+ KL+
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL-------- 1341
Query: 650 LPPEGEEEKTQAYYVIKAAQE-KEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNN 708
EEE+ + E K+ L+R L+ +++ ++K++ +T++ L
Sbjct: 1342 -----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396
Query: 709 YKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLA 768
+++ + +T Q EE+ A D+ + K R +EL + + ++N ++ +L
Sbjct: 1397 FQKEIENLTQ---------QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1447
Query: 769 N-------------NVKEKLS-----------EKQAYSFQLSKETE---EQKPKLERVTK 801
N+ K + EK+ + L++ E E K +LER K
Sbjct: 1448 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 802 QCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIR 853
L E+ L +KD+ + + + ++EM + E E++
Sbjct: 1508 M---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Score = 93.2 bits (230), Expect = 1e-18
Identities = 106/562 (18%), Positives = 234/562 (41%), Gaps = 57/562 (10%)
Query: 332 ISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEK---DV 388
+++ ++++ + LQKTK + + +LKE+ +K + E+ L++ L+ E + +
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 389 KEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQ 448
+E+ V+L K L + E++ +E+ +++ R + Q LD E ++
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ-----QMLDLEEQLEE 961
Query: 449 EIMYSQDFHIQQV--ERRMSRLKGEI---------NSEEKQALEAKIVELRKSL---EEK 494
E Q +++V E ++ +L+ EI S+E++ LE +I +L +L EEK
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 495 KSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTK------------------INEL 536
L+ + + + ++L K K+ E + L K I EL
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 537 NLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAM 596
+ + + E+EL A D + + N +++ + E++ S + +
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 597 EERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEE 656
+ EE++ KT L + ++E + +R ++ LK + T E
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRA----KREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 657 EKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKV 716
+ A V + ++ E+ +R LD EKE L L+VL + KK+
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 717 TPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLS 776
E + K E+ RA EL + + ++N ++ + + N + K
Sbjct: 1258 EAQVQELQSKCSDGERARA-------------ELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 777 EKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHK 836
+ LS + ++ + L+ T+Q ++ ++R L++ ++ ++ D ++ + +
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 837 VIDEMLVDIIEENTEIRIILQT 858
I + + + + +++ T
Sbjct: 1365 HISTLNIQLSDSKKKLQDFAST 1386
Score = 82.8 bits (203), Expect = 1e-15
Identities = 104/559 (18%), Positives = 221/559 (39%), Gaps = 53/559 (9%)
Query: 4 EFLAELHWEDGFAIPVANEENKLLEDQLSKLK---DERASLQDELREYEERINSMTSHFK 60
E L + + E A + L+ +L L D + L L + + + + + + K
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 61 NVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQR----LENEMASILEKKS 116
N+ + + + +A RE E++ A A E K+E++R L+ EM ++ K
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1521
Query: 117 DKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALT----------------L 160
D + + + L+ QM + LE LE+ DA L
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEE-LEDELQATEDAKLRLEVNMQALKGQFERDL 1580
Query: 161 QKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNER 220
Q +Q++ K R L QL E +RK + A K D + + +
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERK-------QRALAAAAKKKLEGDLKDLELQA 1633
Query: 221 QELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFE 280
IK E I+Q++K + + EL + E KE K +S + + +
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693
Query: 281 KRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIH 340
+ ++ A+R A + + + +L EL S + N + L I+++++++
Sbjct: 1694 EDLAAAER-------ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 341 EETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKG 400
EE ++ + + ++++ + + A E ++ E+ KE+ +L+ ++G
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806
Query: 401 VLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQ 460
+ K + S I + + L Q+++ E + + +D +++
Sbjct: 1807 AVKSKFK-------------STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 461 VERRMS--RLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKA 518
+ ++ R E E+ + A++ +L++ LEE + + +KL +L ++
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Query: 519 HSKNSDEKQSLMTKINELN 537
+ E +L +K+ N
Sbjct: 1914 NEAMGREVNALKSKLRRGN 1932
Score = 79.3 bits (194), Expect = 2e-14
Identities = 103/501 (20%), Positives = 199/501 (39%), Gaps = 40/501 (7%)
Query: 32 SKLKDERASLQDELREYEERINSMTSHFKNV---KQELSITQSLCKARERETESEEHFKA 88
SK DER + E RE E + S+ + K+EL T + KA + S +
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 89 IAQRELGRVKDEIQRLENEMASILEKKSDK----ENGIFKATQKLDGLKCQMNWDQQALE 144
EL + K ++ EM + LE+ D+ E+ + + LK Q D QA +
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 145 AWLEESAHKDSDALTLQKYAQQDDNKIRALTL--------QLERLTLECNQKRKILDNEL 196
EE + L + +D+ K RAL L+ L L+ + K + +
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 197 TETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDI-----DNCALELARI 251
+ Q ++ ++ R E+ + ++ + + D+ D A E AR
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR- 1703
Query: 252 KQETREKENLVKEKIKFLESEIGNNTE---FEKRISVADRKLL-----------KCRTAY 297
KQ EKE L +E L E E RI+ + +L + R A
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 298 QDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHE-ETARLQKTKNHNEII 356
Q E QL EL + ++T + S + L + +++ +HE E A K K+ +
Sbjct: 1764 QQAE----QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819
Query: 357 QTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKE 416
+ K+ ++ E+ + LK+++K +KE+ +Q+ + + + ++ + +
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879
Query: 417 KAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEE 476
K + ++E + +N +KL E + E + + ++ ++ R
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPS 1939
Query: 477 KQALEAKIVELRKSLEEKKST 497
+++ +++E EE+ T
Sbjct: 1940 RRSGGRRVIENADGSEEETDT 1960
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 142 bits (358), Expect = 1e-33
Identities = 186/869 (21%), Positives = 383/869 (44%), Gaps = 115/869 (13%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETE 81
EE + ED+L K K+ + ++EL+E E++ + +T KN+ QE + + E
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQE-----------QLQAE 906
Query: 82 SEEHFKAIAQR-ELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQ 140
+E + +A R L K E++ + +EM + LE++ D+ Q+L + +M
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-------GQQLQAERKKMAQQM 959
Query: 141 QALEAWLEESAHKDSDALTLQKY-AQQDDNKIRALTLQLERLTLECNQKRKILDNELTET 199
LE LEE L L+K A+ K+ L ++ + +++RK+L+ +++
Sbjct: 960 LDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 200 ISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKR-----------DGD-------I 241
+ E ++ A++ K+ N+ + +I + E +++ +K +GD I
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 242 DNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHE 301
+ ++A +K + +KE ++ + L+ EI K+I ++ E
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI--------------RELE 1124
Query: 302 TSRIQLKGELDSLKATVNRTSSDLEALRKNISKIK---KDIHEETARLQKTKNHNEIIQT 358
L+ +LDS +A N+ L + + +K +D + TA Q+ + E T
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 359 KLKE-ITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEK 417
LK+ + E+T S E +++M ++ + V+E+ QL K + QT +
Sbjct: 1185 VLKKALDEETRSHE---AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241
Query: 418 AVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMS---RLKGEINS 474
+ E+ + + + H+ +KL+ + +Q+++ + S R + E+N
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQ--------------VQELQSKCSDGERARAELN- 1286
Query: 475 EEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKIN 534
++ L+ ++ + L E + L + L + L ++ + + +K ++ TK+
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 535 ELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYT 594
+L + + +LD+ KQ+L + L +++ +++ L A V +LE+ K++
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406
Query: 595 AMEERT---EEIKVHKTMLASQIRYVDQERENISTEF---RERLSKIEKLKNRYEILTVV 648
+E T EE L + QE +++ + R+ +S +EK + +++ L
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL-- 1464
Query: 649 MLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQV---LNSC 705
EE+ + Y A E++ + E K KA ALE L+ L
Sbjct: 1465 -----AEEKNISSKY----ADERDRAEAEA---REKETKALSLARALEEALEAKEELERT 1512
Query: 706 NNNYKQSFKKVTPSSDEYELKI-QLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVI 764
N K + + S D+ + +LE+ KRA++ + + Q+ EL++++Q+ E+ +
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 765 E--------HLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLK-D 815
E +++ + + + QL ++ E + +LE KQ A + L+ D
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 816 TKD-ETMEEQDIKLRE--MKQFHKVIDEM 841
KD E + IK RE +KQ K+ +M
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Score = 129 bits (323), Expect = 2e-29
Identities = 183/903 (20%), Positives = 383/903 (42%), Gaps = 153/903 (16%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
L+ Q+++LK + A ++EL+ R++ + N +++ + + + +SE
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAW 146
+ A+++ + +E++ L+ E+ L+ + ++ K Q++ LK ++ + ++ EA
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200
Query: 147 LEESAHKDSDALT-----LQKY----AQQDDNKIRALTLQLERLTL------------EC 185
++E K + A+ L+++ A D NK TL+ E L E
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK---QTLEKENADLAGELRVLGQAKQEV 1257
Query: 186 NQKRKILDNELTETISAQLELDKAAQDFR-KIHNERQELIKQWENTIEQMQKRDGDIDNC 244
K+K L+ ++ E S + ++A + K+H + E+ E+ + + +G
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV----ESVTGMLNEAEGKAIKL 1313
Query: 245 ALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSR 304
A ++A + + ++ + L++E+ T + +S R+L + R + QD
Sbjct: 1314 AKDVASLSSQLQDTQELLQEE-----------TRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 305 IQLKGELDSLKATVNRTSSD-----------LEALRKNISKIKKDI------HEETA--- 344
++ K L+ +T+N SD +EAL + + +K+I +EE A
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 345 -RLQKTKNHNEIIQTKLKEIT-------EKTMSVEEKATNLEDMLKEE---------EKD 387
+L+KTKN +Q +L ++ + ++E+K + +L EE E+D
Sbjct: 1423 DKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 388 VKEVDVQLNLIKGVLFKKAQELQTETMKE--------KAVLSEIEGTRSSLKHLNHQLQK 439
E + + K + +A E E +E KA + ++ ++ + H+L+K
Sbjct: 1480 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539
Query: 440 ------LDFETLKQQ------EIMYSQDFHIQQVERRMSRLKGEI----------NSEEK 477
E +K Q E+ ++D ++ +E M LKG+ N E++
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKR 1598
Query: 478 QALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELN 537
+ L+ ++ E LE+++ L KKL DL ++ ++ + ++ +L
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658
Query: 538 LFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAME 597
+ ++EL+ A+ + ++ + + K L E++ + E+ ++Q E
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Query: 598 ERTEEIKVH---KTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILT--VVMLPP 652
E EE+ + L + R ++ + E E +E + +R T L
Sbjct: 1719 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778
Query: 653 EGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQS 712
E E++ A K +++L+R+ L +K+++ E + K
Sbjct: 1779 ELATERSTAQ---KNESARQQLERQNKELRSKLHEMEGAV-----------------KSK 1818
Query: 713 FKKVTPSSDEYELKI-QLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEH---LA 768
FK + E KI QLEEQ V+++ R KQ + L++ + ++ L +E +A
Sbjct: 1819 FKSTIAA---LEAKIAQLEEQ---VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872
Query: 769 NNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKL 828
KE+ + A QL ++ EE + + +R+ KL +E+ DE E +
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL-------DEATESNEAMG 1925
Query: 829 REM 831
RE+
Sbjct: 1926 REV 1928
Score = 118 bits (296), Expect = 2e-26
Identities = 199/930 (21%), Positives = 400/930 (43%), Gaps = 145/930 (15%)
Query: 20 ANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERE 79
A + K LED++ + D+ L E + EERI+ +T+ N+ +E ++L K + +
Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT---NLAEEEEKAKNLTKLKNK- 1038
Query: 80 TESEEHFKAIAQRELGRVKDEIQRLENEMASILEKK-----SDKENGIFKATQKLDGLKC 134
H I++ E+ K+E R E E L++K SD I ++ LK
Sbjct: 1039 -----HESMISELEVRLKKEEKSRQELEK---LKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 135 QMNWDQQALEAWL----EESAHKDSDALTLQKYA------QQDDNKIRALTLQLERLTLE 184
Q+ ++ L+A L +E A K++ +++ Q+D + RA + E+ +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 185 CNQKRKILDNELTETISA---QLELD-KAAQDFRKIHNERQELIKQWENTIEQMQKRDGD 240
++ + L EL +T+ + Q EL K Q+ + E + E +++M+++
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 241 IDNCALELARIKQETREKENLVKEKIKFLESEIGN-----------NTEFEKRISVADRK 289
E +++Q R K NL K K + LE E + E E + + +
Sbjct: 1211 AVEELTE--QLEQFKRAKANLDKNK-QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 290 LLKCRTAYQDHETSRIQL-------KGELDSLKATVNRTSSDLEALRKNISKIKKDIHEE 342
+ + ++ D E +R +L + E++S+ +N L K+++ + + +
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 343 TARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVL 402
LQ+ + TKL+++ E+ S++++ + + E+ + +++QL+ K L
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 403 ----------------FKKAQELQTETMKEK-AVLSEIEGTRSSLKHLNHQLQKLDFETL 445
F+K E T+ +EK A ++E T++ L +L L +
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN---RLQQELDDLVVDLD 1444
Query: 446 KQQEIMYSQDFHIQQVERRMSRLKGE---INSE----------EKQALEAKIVELRKSLE 492
Q++++ ++++ +R+ +L E I+S+ E + E K + L ++LE
Sbjct: 1445 NQRQLV----SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 493 EKKSTCGLLETQIKKLH---NDLYFIKKAHSKNSDE----KQSLMTKINELNLFIDRSEK 545
E LE K L DL K KN E K++L T++ E+ ++ E
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 546 ELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQ---QLYTAMEERTEE 602
EL + K L +E N+ L+ + R++ +A + + EKR+Q QL+ E E+
Sbjct: 1561 ELQATEDAK--LRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH-EYETELED 1614
Query: 603 IKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAY 662
+ + + A+ + ++ + +++ L +K R E + + K QA
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDL------ELQADSAIKGREEAIK--------QLRKLQA- 1659
Query: 663 YVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDE 722
+ +E E+ + D + A + EK+ +LE L L +++ K+ +E
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1719
Query: 723 Y--ELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIE---HLANNVKEKLSE 777
EL L + DEK R + R I +L+E+++ + ++ + A E+LS
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEAR-IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778
Query: 778 KQAYSFQLSKETEEQKPKLERVTKQ-------------------CAKLTKEIRLLKDTKD 818
+ A +++ E + +LER K+ A L +I L++ +
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838
Query: 819 ETMEEQDIKLREMKQFHKVIDEMLVDIIEE 848
+ E+ + +KQ K + E+L+ + +E
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Score = 96.7 bits (239), Expect = 9e-20
Identities = 147/772 (19%), Positives = 321/772 (41%), Gaps = 133/772 (17%)
Query: 148 EESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELD 207
EE K+ + ++ Q+ +N+++ L + +LT E N L E + A+ EL
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE--------KNLLQEQLQAETELY 910
Query: 208 KAAQDFR-KIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKI 266
A++ R ++ ++QEL E + +M+ AR+++E + L E+
Sbjct: 911 AEAEEMRVRLAAKKQEL----EEILHEME-------------ARLEEEEDRGQQLQAERK 953
Query: 267 KFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLE 326
K + + + E+ + + L+ TA E +L+ E+ + N+ S + +
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTA----EAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 327 ALRKNISKIKKDIHEETAR---LQKTKNHNEI----IQTKLKEITEKTMSVEEKATNLED 379
L + IS + ++ EE + L K KN +E ++ +LK+ + +E+ LE
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1069
Query: 380 MLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQK 439
+ + + ++ Q+ +K L KK +ELQ + +++ ++ L +
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 440 LDFETLKQQEIMYSQDFHIQQVERRMSRLKGEI-----NSEEKQALEAK----IVELRKS 490
L + ++ + + + + LK E+ ++ +Q L AK + L+K+
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 491 LEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKA 550
L+E+ + E Q++++ ++ H++ +E + + +D++++ L+K
Sbjct: 1190 LDEETRSH---EAQVQEM-------RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 551 KGFKQDLMIEDNLL---KLEVKRTREMLHSKAEEVLSL----EKRKQQLYTAMEERTEEI 603
DL E +L K EV+ ++ L ++ +E+ S E+ + +L + + E+
Sbjct: 1240 NA---DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 604 KVHKTML--------------ASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVM 649
+ ML AS + +E + E R++L+ KL+
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL-------- 1348
Query: 650 LPPEGEEEKTQAYYVIKAAQE-KEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNN 708
EEE+ + E K+ L+R L+ +++ ++K++ +T++ L
Sbjct: 1349 -----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403
Query: 709 YKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLA 768
+++ + +T Q EE+ A D+ + K R +EL + + ++N ++ +L
Sbjct: 1404 FQKEIENLTQ---------QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1454
Query: 769 N-------------NVKEKLS-----------EKQAYSFQLSKETE---EQKPKLERVTK 801
N+ K + EK+ + L++ E E K +LER K
Sbjct: 1455 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 802 QCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIR 853
L E+ L +KD+ + + + ++EM + E E++
Sbjct: 1515 M---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Score = 93.2 bits (230), Expect = 1e-18
Identities = 106/562 (18%), Positives = 234/562 (41%), Gaps = 57/562 (10%)
Query: 332 ISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEK---DV 388
+++ ++++ + LQKTK + + +LKE+ +K + E+ L++ L+ E + +
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 389 KEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQ 448
+E+ V+L K L + E++ +E+ +++ R + Q LD E ++
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ-----QMLDLEEQLEE 968
Query: 449 EIMYSQDFHIQQV--ERRMSRLKGEI---------NSEEKQALEAKIVELRKSL---EEK 494
E Q +++V E ++ +L+ EI S+E++ LE +I +L +L EEK
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 495 KSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTK------------------INEL 536
L+ + + + ++L K K+ E + L K I EL
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 537 NLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAM 596
+ + + E+EL A D + + N +++ + E++ S + +
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 597 EERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEE 656
+ EE++ KT L + ++E + +R ++ LK + T E
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRA----KREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 657 EKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKV 716
+ A V + ++ E+ +R LD EKE L L+VL + KK+
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 717 TPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLS 776
E + K E+ RA EL + + ++N ++ + + N + K
Sbjct: 1265 EAQVQELQSKCSDGERARA-------------ELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 777 EKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHK 836
+ LS + ++ + L+ T+Q ++ ++R L++ ++ ++ D ++ + +
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 837 VIDEMLVDIIEENTEIRIILQT 858
I + + + + +++ T
Sbjct: 1372 HISTLNIQLSDSKKKLQDFAST 1393
Score = 82.8 bits (203), Expect = 1e-15
Identities = 104/559 (18%), Positives = 221/559 (39%), Gaps = 53/559 (9%)
Query: 4 EFLAELHWEDGFAIPVANEENKLLEDQLSKLK---DERASLQDELREYEERINSMTSHFK 60
E L + + E A + L+ +L L D + L L + + + + + + K
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 61 NVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQR----LENEMASILEKKS 116
N+ + + + +A RE E++ A A E K+E++R L+ EM ++ K
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1528
Query: 117 DKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALT----------------L 160
D + + + L+ QM + LE LE+ DA L
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEE-LEDELQATEDAKLRLEVNMQALKGQFERDL 1587
Query: 161 QKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNER 220
Q +Q++ K R L QL E +RK + A K D + + +
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERK-------QRALAAAAKKKLEGDLKDLELQA 1640
Query: 221 QELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFE 280
IK E I+Q++K + + EL + E KE K +S + + +
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Query: 281 KRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIH 340
+ ++ A+R A + + + +L EL S + N + L I+++++++
Sbjct: 1701 EDLAAAER-------ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 341 EETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKG 400
EE ++ + + ++++ + + A E ++ E+ KE+ +L+ ++G
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813
Query: 401 VLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQ 460
+ K + S I + + L Q+++ E + + +D +++
Sbjct: 1814 AVKSKFK-------------STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 461 VERRMS--RLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKA 518
+ ++ R E E+ + A++ +L++ LEE + + +KL +L ++
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Query: 519 HSKNSDEKQSLMTKINELN 537
+ E +L +K+ N
Sbjct: 1921 NEAMGREVNALKSKLRRGN 1939
Score = 79.3 bits (194), Expect = 2e-14
Identities = 103/501 (20%), Positives = 199/501 (39%), Gaps = 40/501 (7%)
Query: 32 SKLKDERASLQDELREYEERINSMTSHFKNV---KQELSITQSLCKARERETESEEHFKA 88
SK DER + E RE E + S+ + K+EL T + KA + S +
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 89 IAQRELGRVKDEIQRLENEMASILEKKSDK----ENGIFKATQKLDGLKCQMNWDQQALE 144
EL + K ++ EM + LE+ D+ E+ + + LK Q D QA +
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 145 AWLEESAHKDSDALTLQKYAQQDDNKIRALTL--------QLERLTLECNQKRKILDNEL 196
EE + L + +D+ K RAL L+ L L+ + K + +
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 197 TETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDI-----DNCALELARI 251
+ Q ++ ++ R E+ + ++ + + D+ D A E AR
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR- 1710
Query: 252 KQETREKENLVKEKIKFLESEIGNNTE---FEKRISVADRKLL-----------KCRTAY 297
KQ EKE L +E L E E RI+ + +L + R A
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 298 QDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHE-ETARLQKTKNHNEII 356
Q E QL EL + ++T + S + L + +++ +HE E A K K+ +
Sbjct: 1771 QQAE----QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826
Query: 357 QTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKE 416
+ K+ ++ E+ + LK+++K +KE+ +Q+ + + + ++ + +
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886
Query: 417 KAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEE 476
K + ++E + +N +KL E + E + + ++ ++ R
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPS 1946
Query: 477 KQALEAKIVELRKSLEEKKST 497
+++ +++E EE+ T
Sbjct: 1947 RRSGGRRVIENADGSEEETDT 1967
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 142 bits (358), Expect = 1e-33
Identities = 186/869 (21%), Positives = 383/869 (44%), Gaps = 115/869 (13%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETE 81
EE + ED+L K K+ + ++EL+E E++ + +T KN+ QE + + E
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQE-----------QLQAE 906
Query: 82 SEEHFKAIAQR-ELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQ 140
+E + +A R L K E++ + +EM + LE++ D+ Q+L + +M
Sbjct: 907 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-------GQQLQAERKKMAQQM 959
Query: 141 QALEAWLEESAHKDSDALTLQKY-AQQDDNKIRALTLQLERLTLECNQKRKILDNELTET 199
LE LEE L L+K A+ K+ L ++ + +++RK+L+ +++
Sbjct: 960 LDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1018
Query: 200 ISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKR-----------DGD-------I 241
+ E ++ A++ K+ N+ + +I + E +++ +K +GD I
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 242 DNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHE 301
+ ++A +K + +KE ++ + L+ EI K+I ++ E
Sbjct: 1079 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI--------------RELE 1124
Query: 302 TSRIQLKGELDSLKATVNRTSSDLEALRKNISKIK---KDIHEETARLQKTKNHNEIIQT 358
L+ +LDS +A N+ L + + +K +D + TA Q+ + E T
Sbjct: 1125 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1184
Query: 359 KLKE-ITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEK 417
LK+ + E+T S E +++M ++ + V+E+ QL K + QT +
Sbjct: 1185 VLKKALDEETRSHE---AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1241
Query: 418 AVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMS---RLKGEINS 474
+ E+ + + + H+ +KL+ + +Q+++ + S R + E+N
Sbjct: 1242 DLAGELRVLGQAKQEVEHKKKKLEAQ--------------VQELQSKCSDGERARAELN- 1286
Query: 475 EEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKIN 534
++ L+ ++ + L E + L + L + L ++ + + +K ++ TK+
Sbjct: 1287 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1346
Query: 535 ELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYT 594
+L + + +LD+ KQ+L + L +++ +++ L A V +LE+ K++
Sbjct: 1347 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1406
Query: 595 AMEERT---EEIKVHKTMLASQIRYVDQERENISTEF---RERLSKIEKLKNRYEILTVV 648
+E T EE L + QE +++ + R+ +S +EK + +++ L
Sbjct: 1407 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL-- 1464
Query: 649 MLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQV---LNSC 705
EE+ + Y A E++ + E K KA ALE L+ L
Sbjct: 1465 -----AEEKNISSKY----ADERDRAEAEA---REKETKALSLARALEEALEAKEELERT 1512
Query: 706 NNNYKQSFKKVTPSSDEYELKI-QLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVI 764
N K + + S D+ + +LE+ KRA++ + + Q+ EL++++Q+ E+ +
Sbjct: 1513 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 765 E--------HLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLK-D 815
E +++ + + + QL ++ E + +LE KQ A + L+ D
Sbjct: 1573 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1632
Query: 816 TKD-ETMEEQDIKLRE--MKQFHKVIDEM 841
KD E + IK RE +KQ K+ +M
Sbjct: 1633 LKDLELQADSAIKGREEAIKQLRKLQAQM 1661
Score = 129 bits (323), Expect = 2e-29
Identities = 183/903 (20%), Positives = 383/903 (42%), Gaps = 153/903 (16%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
L+ Q+++LK + A ++EL+ R++ + N +++ + + + +SE
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1140
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAW 146
+ A+++ + +E++ L+ E+ L+ + ++ K Q++ LK ++ + ++ EA
Sbjct: 1141 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1200
Query: 147 LEESAHKDSDALT-----LQKY----AQQDDNKIRALTLQLERLTL------------EC 185
++E K + A+ L+++ A D NK TL+ E L E
Sbjct: 1201 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK---QTLEKENADLAGELRVLGQAKQEV 1257
Query: 186 NQKRKILDNELTETISAQLELDKAAQDFR-KIHNERQELIKQWENTIEQMQKRDGDIDNC 244
K+K L+ ++ E S + ++A + K+H + E+ E+ + + +G
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV----ESVTGMLNEAEGKAIKL 1313
Query: 245 ALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSR 304
A ++A + + ++ + L++E+ T + +S R+L + R + QD
Sbjct: 1314 AKDVASLSSQLQDTQELLQEE-----------TRQKLNVSTKLRQLEEERNSLQDQLDEE 1362
Query: 305 IQLKGELDSLKATVNRTSSD-----------LEALRKNISKIKKDI------HEETA--- 344
++ K L+ +T+N SD +EAL + + +K+I +EE A
Sbjct: 1363 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1422
Query: 345 -RLQKTKNHNEIIQTKLKEIT-------EKTMSVEEKATNLEDMLKEE---------EKD 387
+L+KTKN +Q +L ++ + ++E+K + +L EE E+D
Sbjct: 1423 DKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1479
Query: 388 VKEVDVQLNLIKGVLFKKAQELQTETMKE--------KAVLSEIEGTRSSLKHLNHQLQK 439
E + + K + +A E E +E KA + ++ ++ + H+L+K
Sbjct: 1480 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1539
Query: 440 ------LDFETLKQQ------EIMYSQDFHIQQVERRMSRLKGEI----------NSEEK 477
E +K Q E+ ++D ++ +E M LKG+ N E++
Sbjct: 1540 SKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKR 1598
Query: 478 QALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELN 537
+ L+ ++ E LE+++ L KKL DL ++ ++ + ++ +L
Sbjct: 1599 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658
Query: 538 LFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAME 597
+ ++EL+ A+ + ++ + + K L E++ + E+ ++Q E
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1718
Query: 598 ERTEEIKVH---KTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILT--VVMLPP 652
E EE+ + L + R ++ + E E +E + +R T L
Sbjct: 1719 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778
Query: 653 EGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQS 712
E E++ A K +++L+R+ L +K+++ E + K
Sbjct: 1779 ELATERSTAQ---KNESARQQLERQNKELRSKLHEMEGAV-----------------KSK 1818
Query: 713 FKKVTPSSDEYELKI-QLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEH---LA 768
FK + E KI QLEEQ V+++ R KQ + L++ + ++ L +E +A
Sbjct: 1819 FKSTIAA---LEAKIAQLEEQ---VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872
Query: 769 NNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKL 828
KE+ + A QL ++ EE + + +R+ KL +E+ DE E +
Sbjct: 1873 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL-------DEATESNEAMG 1925
Query: 829 REM 831
RE+
Sbjct: 1926 REV 1928
Score = 118 bits (296), Expect = 2e-26
Identities = 199/930 (21%), Positives = 400/930 (43%), Gaps = 145/930 (15%)
Query: 20 ANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERE 79
A + K LED++ + D+ L E + EERI+ +T+ N+ +E ++L K + +
Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT---NLAEEEEKAKNLTKLKNK- 1038
Query: 80 TESEEHFKAIAQRELGRVKDEIQRLENEMASILEKK-----SDKENGIFKATQKLDGLKC 134
H I++ E+ K+E R E E L++K SD I ++ LK
Sbjct: 1039 -----HESMISELEVRLKKEEKSRQELEK---LKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 135 QMNWDQQALEAWL----EESAHKDSDALTLQKYA------QQDDNKIRALTLQLERLTLE 184
Q+ ++ L+A L +E A K++ +++ Q+D + RA + E+ +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 185 CNQKRKILDNELTETISA---QLELD-KAAQDFRKIHNERQELIKQWENTIEQMQKRDGD 240
++ + L EL +T+ + Q EL K Q+ + E + E +++M+++
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210
Query: 241 IDNCALELARIKQETREKENLVKEKIKFLESEIGN-----------NTEFEKRISVADRK 289
E +++Q R K NL K K + LE E + E E + + +
Sbjct: 1211 AVEELTE--QLEQFKRAKANLDKNK-QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1267
Query: 290 LLKCRTAYQDHETSRIQL-------KGELDSLKATVNRTSSDLEALRKNISKIKKDIHEE 342
+ + ++ D E +R +L + E++S+ +N L K+++ + + +
Sbjct: 1268 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1327
Query: 343 TARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVL 402
LQ+ + TKL+++ E+ S++++ + + E+ + +++QL+ K L
Sbjct: 1328 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1387
Query: 403 ----------------FKKAQELQTETMKEK-AVLSEIEGTRSSLKHLNHQLQKLDFETL 445
F+K E T+ +EK A ++E T++ L +L L +
Sbjct: 1388 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN---RLQQELDDLVVDLD 1444
Query: 446 KQQEIMYSQDFHIQQVERRMSRLKGE---INSE----------EKQALEAKIVELRKSLE 492
Q++++ ++++ +R+ +L E I+S+ E + E K + L ++LE
Sbjct: 1445 NQRQLV----SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1500
Query: 493 EKKSTCGLLETQIKKLH---NDLYFIKKAHSKNSDE----KQSLMTKINELNLFIDRSEK 545
E LE K L DL K KN E K++L T++ E+ ++ E
Sbjct: 1501 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1560
Query: 546 ELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQ---QLYTAMEERTEE 602
EL + K L +E N+ L+ + R++ +A + + EKR+Q QL+ E E+
Sbjct: 1561 ELQATEDAK--LRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH-EYETELED 1614
Query: 603 IKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAY 662
+ + + A+ + ++ + +++ L +K R E + + K QA
Sbjct: 1615 ERKQRALAAAAKKKLEGDLKDL------ELQADSAIKGREEAIK--------QLRKLQA- 1659
Query: 663 YVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDE 722
+ +E E+ + D + A + EK+ +LE L L +++ K+ +E
Sbjct: 1660 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1719
Query: 723 Y--ELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIE---HLANNVKEKLSE 777
EL L + DEK R + R I +L+E+++ + ++ + A E+LS
Sbjct: 1720 LAEELASSLSGRNALQDEKRRLEAR-IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1778
Query: 778 KQAYSFQLSKETEEQKPKLERVTKQ-------------------CAKLTKEIRLLKDTKD 818
+ A +++ E + +LER K+ A L +I L++ +
Sbjct: 1779 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1838
Query: 819 ETMEEQDIKLREMKQFHKVIDEMLVDIIEE 848
+ E+ + +KQ K + E+L+ + +E
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDE 1868
Score = 96.7 bits (239), Expect = 9e-20
Identities = 147/772 (19%), Positives = 321/772 (41%), Gaps = 133/772 (17%)
Query: 148 EESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELD 207
EE K+ + ++ Q+ +N+++ L + +LT E N L E + A+ EL
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE--------KNLLQEQLQAETELY 910
Query: 208 KAAQDFR-KIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKI 266
A++ R ++ ++QEL E + +M+ AR+++E + L E+
Sbjct: 911 AEAEEMRVRLAAKKQEL----EEILHEME-------------ARLEEEEDRGQQLQAERK 953
Query: 267 KFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLE 326
K + + + E+ + + L+ TA E +L+ E+ + N+ S + +
Sbjct: 954 KMAQQMLDLEEQLEEEEAARQKLQLEKVTA----EAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 327 ALRKNISKIKKDIHEETAR---LQKTKNHNEI----IQTKLKEITEKTMSVEEKATNLED 379
L + IS + ++ EE + L K KN +E ++ +LK+ + +E+ LE
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1069
Query: 380 MLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQK 439
+ + + ++ Q+ +K L KK +ELQ + +++ ++ L +
Sbjct: 1070 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1129
Query: 440 LDFETLKQQEIMYSQDFHIQQVERRMSRLKGEI-----NSEEKQALEAK----IVELRKS 490
L + ++ + + + + LK E+ ++ +Q L AK + L+K+
Sbjct: 1130 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 491 LEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKA 550
L+E+ + E Q++++ ++ H++ +E + + +D++++ L+K
Sbjct: 1190 LDEETRSH---EAQVQEM-------RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1239
Query: 551 KGFKQDLMIEDNLL---KLEVKRTREMLHSKAEEVLSL----EKRKQQLYTAMEERTEEI 603
DL E +L K EV+ ++ L ++ +E+ S E+ + +L + + E+
Sbjct: 1240 NA---DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1296
Query: 604 KVHKTML--------------ASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVM 649
+ ML AS + +E + E R++L+ KL+
Sbjct: 1297 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL-------- 1348
Query: 650 LPPEGEEEKTQAYYVIKAAQE-KEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNN 708
EEE+ + E K+ L+R L+ +++ ++K++ +T++ L
Sbjct: 1349 -----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1403
Query: 709 YKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLA 768
+++ + +T Q EE+ A D+ + K R +EL + + ++N ++ +L
Sbjct: 1404 FQKEIENLTQ---------QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1454
Query: 769 N-------------NVKEKLS-----------EKQAYSFQLSKETE---EQKPKLERVTK 801
N+ K + EK+ + L++ E E K +LER K
Sbjct: 1455 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 802 QCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIR 853
L E+ L +KD+ + + + ++EM + E E++
Sbjct: 1515 M---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1563
Score = 93.2 bits (230), Expect = 1e-18
Identities = 106/562 (18%), Positives = 234/562 (41%), Gaps = 57/562 (10%)
Query: 332 ISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEK---DV 388
+++ ++++ + LQKTK + + +LKE+ +K + E+ L++ L+ E + +
Sbjct: 854 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 913
Query: 389 KEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQ 448
+E+ V+L K L + E++ +E+ +++ R + Q LD E ++
Sbjct: 914 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ-----QMLDLEEQLEE 968
Query: 449 EIMYSQDFHIQQV--ERRMSRLKGEI---------NSEEKQALEAKIVELRKSL---EEK 494
E Q +++V E ++ +L+ EI S+E++ LE +I +L +L EEK
Sbjct: 969 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1028
Query: 495 KSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTK------------------INEL 536
L+ + + + ++L K K+ E + L K I EL
Sbjct: 1029 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1088
Query: 537 NLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAM 596
+ + + E+EL A D + + N +++ + E++ S + +
Sbjct: 1089 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1148
Query: 597 EERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEE 656
+ EE++ KT L + ++E + +R ++ LK + T E
Sbjct: 1149 RDLGEELEALKTELEDTLDSTATQQELRA----KREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 657 EKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKV 716
+ A V + ++ E+ +R LD EKE L L+VL + KK+
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 717 TPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLS 776
E + K E+ RA EL + + ++N ++ + + N + K
Sbjct: 1265 EAQVQELQSKCSDGERARA-------------ELNDKVHKLQNEVESVTGMLNEAEGKAI 1311
Query: 777 EKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHK 836
+ LS + ++ + L+ T+Q ++ ++R L++ ++ ++ D ++ + +
Sbjct: 1312 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1371
Query: 837 VIDEMLVDIIEENTEIRIILQT 858
I + + + + +++ T
Sbjct: 1372 HISTLNIQLSDSKKKLQDFAST 1393
Score = 82.0 bits (201), Expect = 2e-15
Identities = 103/555 (18%), Positives = 220/555 (39%), Gaps = 53/555 (9%)
Query: 4 EFLAELHWEDGFAIPVANEENKLLEDQLSKLK---DERASLQDELREYEERINSMTSHFK 60
E L + + E A + L+ +L L D + L L + + + + + + K
Sbjct: 1409 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1468
Query: 61 NVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQR----LENEMASILEKKS 116
N+ + + + +A RE E++ A A E K+E++R L+ EM ++ K
Sbjct: 1469 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1528
Query: 117 DKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALT----------------L 160
D + + + L+ QM + LE LE+ DA L
Sbjct: 1529 DVGKNVHELEKSKRALETQMEEMKTQLEE-LEDELQATEDAKLRLEVNMQALKGQFERDL 1587
Query: 161 QKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNER 220
Q +Q++ K R L QL E +RK + A K D + + +
Sbjct: 1588 QARDEQNEEKRRQLQRQLHEYETELEDERK-------QRALAAAAKKKLEGDLKDLELQA 1640
Query: 221 QELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFE 280
IK E I+Q++K + + EL + E KE K +S + + +
Sbjct: 1641 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1700
Query: 281 KRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIH 340
+ ++ A+R A + + + +L EL S + N + L I+++++++
Sbjct: 1701 EDLAAAER-------ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753
Query: 341 EETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKG 400
EE ++ + + ++++ + + A E ++ E+ KE+ +L+ ++G
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813
Query: 401 VLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQ 460
+ K + S I + + L Q+++ E + + +D +++
Sbjct: 1814 AVKSKFK-------------STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1860
Query: 461 VERRMS--RLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKA 518
+ ++ R E E+ + A++ +L++ LEE + + +KL +L ++
Sbjct: 1861 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1920
Query: 519 HSKNSDEKQSLMTKI 533
+ E +L +K+
Sbjct: 1921 NEAMGREVNALKSKL 1935
Score = 80.9 bits (198), Expect = 5e-15
Identities = 105/482 (21%), Positives = 192/482 (39%), Gaps = 43/482 (8%)
Query: 32 SKLKDERASLQDELREYEERINSMTSHFKNV---KQELSITQSLCKARERETESEEHFKA 88
SK DER + E RE E + S+ + K+EL T + KA + S +
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1531
Query: 89 IAQRELGRVKDEIQRLENEMASILEKKSDK----ENGIFKATQKLDGLKCQMNWDQQALE 144
EL + K ++ EM + LE+ D+ E+ + + LK Q D QA +
Sbjct: 1532 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1591
Query: 145 AWLEESAHKDSDALTLQKYAQQDDNKIRALTL--------QLERLTLECNQKRKILDNEL 196
EE + L + +D+ K RAL L+ L L+ + K + +
Sbjct: 1592 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1651
Query: 197 TETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDI-----DNCALELARI 251
+ Q ++ ++ R E+ + ++ + + D+ D A E AR
Sbjct: 1652 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR- 1710
Query: 252 KQETREKENLVKEKIKFLESEIGNNTE---FEKRISVADRKLL-----------KCRTAY 297
KQ EKE L +E L E E RI+ + +L + R A
Sbjct: 1711 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1770
Query: 298 QDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHE-ETARLQKTKNHNEII 356
Q E QL EL + ++T + S + L + +++ +HE E A K K+ +
Sbjct: 1771 QQAE----QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1826
Query: 357 QTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKE 416
+ K+ ++ E+ + LK+++K +KE+ +Q+ + + + ++ + +
Sbjct: 1827 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1886
Query: 417 KAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEE 476
K + ++E + +N +KL E E S + ++V S+L+G E
Sbjct: 1887 KQLKRQLEEAEEESQRINANRRKLQREL---DEATESNEAMGREVNALKSKLRGPPPQET 1943
Query: 477 KQ 478
Q
Sbjct: 1944 SQ 1945
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 142 bits (358), Expect = 1e-33
Identities = 186/869 (21%), Positives = 383/869 (44%), Gaps = 115/869 (13%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETE 81
EE + ED+L K K+ + ++EL+E E++ + +T KN+ QE + + E
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE-KNLLQE-----------QLQAE 899
Query: 82 SEEHFKAIAQR-ELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQ 140
+E + +A R L K E++ + +EM + LE++ D+ Q+L + +M
Sbjct: 900 TELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDR-------GQQLQAERKKMAQQM 952
Query: 141 QALEAWLEESAHKDSDALTLQKY-AQQDDNKIRALTLQLERLTLECNQKRKILDNELTET 199
LE LEE L L+K A+ K+ L ++ + +++RK+L+ +++
Sbjct: 953 LDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDL 1011
Query: 200 ISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKR-----------DGD-------I 241
+ E ++ A++ K+ N+ + +I + E +++ +K +GD I
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 242 DNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHE 301
+ ++A +K + +KE ++ + L+ EI K+I ++ E
Sbjct: 1072 ADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKI--------------RELE 1117
Query: 302 TSRIQLKGELDSLKATVNRTSSDLEALRKNISKIK---KDIHEETARLQKTKNHNEIIQT 358
L+ +LDS +A N+ L + + +K +D + TA Q+ + E T
Sbjct: 1118 GHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVT 1177
Query: 359 KLKE-ITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEK 417
LK+ + E+T S E +++M ++ + V+E+ QL K + QT +
Sbjct: 1178 VLKKALDEETRSHE---AQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENA 1234
Query: 418 AVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMS---RLKGEINS 474
+ E+ + + + H+ +KL+ + +Q+++ + S R + E+N
Sbjct: 1235 DLAGELRVLGQAKQEVEHKKKKLEAQ--------------VQELQSKCSDGERARAELN- 1279
Query: 475 EEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKIN 534
++ L+ ++ + L E + L + L + L ++ + + +K ++ TK+
Sbjct: 1280 DKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLR 1339
Query: 535 ELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYT 594
+L + + +LD+ KQ+L + L +++ +++ L A V +LE+ K++
Sbjct: 1340 QLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQK 1399
Query: 595 AMEERT---EEIKVHKTMLASQIRYVDQERENISTEF---RERLSKIEKLKNRYEILTVV 648
+E T EE L + QE +++ + R+ +S +EK + +++ L
Sbjct: 1400 EIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLL-- 1457
Query: 649 MLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQV---LNSC 705
EE+ + Y A E++ + E K KA ALE L+ L
Sbjct: 1458 -----AEEKNISSKY----ADERDRAEAEA---REKETKALSLARALEEALEAKEELERT 1505
Query: 706 NNNYKQSFKKVTPSSDEYELKI-QLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVI 764
N K + + S D+ + +LE+ KRA++ + + Q+ EL++++Q+ E+ +
Sbjct: 1506 NKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 765 E--------HLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLK-D 815
E +++ + + + QL ++ E + +LE KQ A + L+ D
Sbjct: 1566 EVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGD 1625
Query: 816 TKD-ETMEEQDIKLRE--MKQFHKVIDEM 841
KD E + IK RE +KQ K+ +M
Sbjct: 1626 LKDLELQADSAIKGREEAIKQLRKLQAQM 1654
Score = 129 bits (323), Expect = 2e-29
Identities = 183/903 (20%), Positives = 383/903 (42%), Gaps = 153/903 (16%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
L+ Q+++LK + A ++EL+ R++ + N +++ + + + +SE
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAA 1133
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAW 146
+ A+++ + +E++ L+ E+ L+ + ++ K Q++ LK ++ + ++ EA
Sbjct: 1134 RNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQ 1193
Query: 147 LEESAHKDSDALT-----LQKY----AQQDDNKIRALTLQLERLTL------------EC 185
++E K + A+ L+++ A D NK TL+ E L E
Sbjct: 1194 VQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK---QTLEKENADLAGELRVLGQAKQEV 1250
Query: 186 NQKRKILDNELTETISAQLELDKAAQDFR-KIHNERQELIKQWENTIEQMQKRDGDIDNC 244
K+K L+ ++ E S + ++A + K+H + E+ E+ + + +G
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV----ESVTGMLNEAEGKAIKL 1306
Query: 245 ALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSR 304
A ++A + + ++ + L++E+ T + +S R+L + R + QD
Sbjct: 1307 AKDVASLSSQLQDTQELLQEE-----------TRQKLNVSTKLRQLEEERNSLQDQLDEE 1355
Query: 305 IQLKGELDSLKATVNRTSSD-----------LEALRKNISKIKKDI------HEETA--- 344
++ K L+ +T+N SD +EAL + + +K+I +EE A
Sbjct: 1356 MEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAY 1415
Query: 345 -RLQKTKNHNEIIQTKLKEIT-------EKTMSVEEKATNLEDMLKEE---------EKD 387
+L+KTKN +Q +L ++ + ++E+K + +L EE E+D
Sbjct: 1416 DKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERD 1472
Query: 388 VKEVDVQLNLIKGVLFKKAQELQTETMKE--------KAVLSEIEGTRSSLKHLNHQLQK 439
E + + K + +A E E +E KA + ++ ++ + H+L+K
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK 1532
Query: 440 ------LDFETLKQQ------EIMYSQDFHIQQVERRMSRLKGEI----------NSEEK 477
E +K Q E+ ++D ++ +E M LKG+ N E++
Sbjct: 1533 SKRALETQMEEMKTQLEELEDELQATEDAKLR-LEVNMQALKGQFERDLQARDEQNEEKR 1591
Query: 478 QALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELN 537
+ L+ ++ E LE+++ L KKL DL ++ ++ + ++ +L
Sbjct: 1592 RQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1651
Query: 538 LFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAME 597
+ ++EL+ A+ + ++ + + K L E++ + E+ ++Q E
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKE 1711
Query: 598 ERTEEIKVH---KTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILT--VVMLPP 652
E EE+ + L + R ++ + E E +E + +R T L
Sbjct: 1712 ELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771
Query: 653 EGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQS 712
E E++ A K +++L+R+ L +K+++ E + K
Sbjct: 1772 ELATERSTAQ---KNESARQQLERQNKELRSKLHEMEGAV-----------------KSK 1811
Query: 713 FKKVTPSSDEYELKI-QLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEH---LA 768
FK + E KI QLEEQ V+++ R KQ + L++ + ++ L +E +A
Sbjct: 1812 FKSTIAA---LEAKIAQLEEQ---VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865
Query: 769 NNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKL 828
KE+ + A QL ++ EE + + +R+ KL +E+ DE E +
Sbjct: 1866 EQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQREL-------DEATESNEAMG 1918
Query: 829 REM 831
RE+
Sbjct: 1919 REV 1921
Score = 118 bits (296), Expect = 2e-26
Identities = 199/930 (21%), Positives = 400/930 (43%), Gaps = 145/930 (15%)
Query: 20 ANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERE 79
A + K LED++ + D+ L E + EERI+ +T+ N+ +E ++L K + +
Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT---NLAEEEEKAKNLTKLKNK- 1031
Query: 80 TESEEHFKAIAQRELGRVKDEIQRLENEMASILEKK-----SDKENGIFKATQKLDGLKC 134
H I++ E+ K+E R E E L++K SD I ++ LK
Sbjct: 1032 -----HESMISELEVRLKKEEKSRQELEK---LKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 135 QMNWDQQALEAWL----EESAHKDSDALTLQKYA------QQDDNKIRALTLQLERLTLE 184
Q+ ++ L+A L +E A K++ +++ Q+D + RA + E+ +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 185 CNQKRKILDNELTETISA---QLELD-KAAQDFRKIHNERQELIKQWENTIEQMQKRDGD 240
++ + L EL +T+ + Q EL K Q+ + E + E +++M+++
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203
Query: 241 IDNCALELARIKQETREKENLVKEKIKFLESEIGN-----------NTEFEKRISVADRK 289
E +++Q R K NL K K + LE E + E E + + +
Sbjct: 1204 AVEELTE--QLEQFKRAKANLDKNK-QTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQ 1260
Query: 290 LLKCRTAYQDHETSRIQL-------KGELDSLKATVNRTSSDLEALRKNISKIKKDIHEE 342
+ + ++ D E +R +L + E++S+ +N L K+++ + + +
Sbjct: 1261 VQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDT 1320
Query: 343 TARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVL 402
LQ+ + TKL+++ E+ S++++ + + E+ + +++QL+ K L
Sbjct: 1321 QELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKL 1380
Query: 403 ----------------FKKAQELQTETMKEK-AVLSEIEGTRSSLKHLNHQLQKLDFETL 445
F+K E T+ +EK A ++E T++ L +L L +
Sbjct: 1381 QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKN---RLQQELDDLVVDLD 1437
Query: 446 KQQEIMYSQDFHIQQVERRMSRLKGE---INSE----------EKQALEAKIVELRKSLE 492
Q++++ ++++ +R+ +L E I+S+ E + E K + L ++LE
Sbjct: 1438 NQRQLV----SNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALE 1493
Query: 493 EKKSTCGLLETQIKKLH---NDLYFIKKAHSKNSDE----KQSLMTKINELNLFIDRSEK 545
E LE K L DL K KN E K++L T++ E+ ++ E
Sbjct: 1494 EALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELED 1553
Query: 546 ELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQ---QLYTAMEERTEE 602
EL + K L +E N+ L+ + R++ +A + + EKR+Q QL+ E E+
Sbjct: 1554 ELQATEDAK--LRLEVNMQALKGQFERDL---QARDEQNEEKRRQLQRQLH-EYETELED 1607
Query: 603 IKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAY 662
+ + + A+ + ++ + +++ L +K R E + + K QA
Sbjct: 1608 ERKQRALAAAAKKKLEGDLKDL------ELQADSAIKGREEAIK--------QLRKLQA- 1652
Query: 663 YVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDE 722
+ +E E+ + D + A + EK+ +LE L L +++ K+ +E
Sbjct: 1653 QMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEE 1712
Query: 723 Y--ELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIE---HLANNVKEKLSE 777
EL L + DEK R + R I +L+E+++ + ++ + A E+LS
Sbjct: 1713 LAEELASSLSGRNALQDEKRRLEAR-IAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSN 1771
Query: 778 KQAYSFQLSKETEEQKPKLERVTKQ-------------------CAKLTKEIRLLKDTKD 818
+ A +++ E + +LER K+ A L +I L++ +
Sbjct: 1772 ELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVE 1831
Query: 819 ETMEEQDIKLREMKQFHKVIDEMLVDIIEE 848
+ E+ + +KQ K + E+L+ + +E
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDE 1861
Score = 96.7 bits (239), Expect = 9e-20
Identities = 147/772 (19%), Positives = 321/772 (41%), Gaps = 133/772 (17%)
Query: 148 EESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELD 207
EE K+ + ++ Q+ +N+++ L + +LT E N L E + A+ EL
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEE--------KNLLQEQLQAETELY 903
Query: 208 KAAQDFR-KIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKI 266
A++ R ++ ++QEL E + +M+ AR+++E + L E+
Sbjct: 904 AEAEEMRVRLAAKKQEL----EEILHEME-------------ARLEEEEDRGQQLQAERK 946
Query: 267 KFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLE 326
K + + + E+ + + L+ TA E +L+ E+ + N+ S + +
Sbjct: 947 KMAQQMLDLEEQLEEEEAARQKLQLEKVTA----EAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 327 ALRKNISKIKKDIHEETAR---LQKTKNHNEI----IQTKLKEITEKTMSVEEKATNLED 379
L + IS + ++ EE + L K KN +E ++ +LK+ + +E+ LE
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEG 1062
Query: 380 MLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQK 439
+ + + ++ Q+ +K L KK +ELQ + +++ ++ L +
Sbjct: 1063 DASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISD 1122
Query: 440 LDFETLKQQEIMYSQDFHIQQVERRMSRLKGEI-----NSEEKQALEAK----IVELRKS 490
L + ++ + + + + LK E+ ++ +Q L AK + L+K+
Sbjct: 1123 LQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 491 LEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKA 550
L+E+ + E Q++++ ++ H++ +E + + +D++++ L+K
Sbjct: 1183 LDEETRSH---EAQVQEM-------RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKE 1232
Query: 551 KGFKQDLMIEDNLL---KLEVKRTREMLHSKAEEVLSL----EKRKQQLYTAMEERTEEI 603
DL E +L K EV+ ++ L ++ +E+ S E+ + +L + + E+
Sbjct: 1233 NA---DLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEV 1289
Query: 604 KVHKTML--------------ASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVM 649
+ ML AS + +E + E R++L+ KL+
Sbjct: 1290 ESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQL-------- 1341
Query: 650 LPPEGEEEKTQAYYVIKAAQE-KEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNN 708
EEE+ + E K+ L+R L+ +++ ++K++ +T++ L
Sbjct: 1342 -----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKR 1396
Query: 709 YKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLA 768
+++ + +T Q EE+ A D+ + K R +EL + + ++N ++ +L
Sbjct: 1397 FQKEIENLTQ---------QYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1447
Query: 769 N-------------NVKEKLS-----------EKQAYSFQLSKETE---EQKPKLERVTK 801
N+ K + EK+ + L++ E E K +LER K
Sbjct: 1448 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 802 QCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIR 853
L E+ L +KD+ + + + ++EM + E E++
Sbjct: 1508 M---LKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQ 1556
Score = 93.2 bits (230), Expect = 1e-18
Identities = 106/562 (18%), Positives = 234/562 (41%), Gaps = 57/562 (10%)
Query: 332 ISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEK---DV 388
+++ ++++ + LQKTK + + +LKE+ +K + E+ L++ L+ E + +
Sbjct: 847 VTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEA 906
Query: 389 KEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQ 448
+E+ V+L K L + E++ +E+ +++ R + Q LD E ++
Sbjct: 907 EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQ-----QMLDLEEQLEE 961
Query: 449 EIMYSQDFHIQQV--ERRMSRLKGEI---------NSEEKQALEAKIVELRKSL---EEK 494
E Q +++V E ++ +L+ EI S+E++ LE +I +L +L EEK
Sbjct: 962 EEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEK 1021
Query: 495 KSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTK------------------INEL 536
L+ + + + ++L K K+ E + L K I EL
Sbjct: 1022 AKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAEL 1081
Query: 537 NLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAM 596
+ + + E+EL A D + + N +++ + E++ S + +
Sbjct: 1082 KMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQK 1141
Query: 597 EERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEE 656
+ EE++ KT L + ++E + +R ++ LK + T E
Sbjct: 1142 RDLGEELEALKTELEDTLDSTATQQELRA----KREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 657 EKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKV 716
+ A V + ++ E+ +R LD EKE L L+VL + KK+
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 717 TPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLS 776
E + K E+ RA EL + + ++N ++ + + N + K
Sbjct: 1258 EAQVQELQSKCSDGERARA-------------ELNDKVHKLQNEVESVTGMLNEAEGKAI 1304
Query: 777 EKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHK 836
+ LS + ++ + L+ T+Q ++ ++R L++ ++ ++ D ++ + +
Sbjct: 1305 KLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLER 1364
Query: 837 VIDEMLVDIIEENTEIRIILQT 858
I + + + + +++ T
Sbjct: 1365 HISTLNIQLSDSKKKLQDFAST 1386
Score = 82.0 bits (201), Expect = 2e-15
Identities = 103/555 (18%), Positives = 220/555 (39%), Gaps = 53/555 (9%)
Query: 4 EFLAELHWEDGFAIPVANEENKLLEDQLSKLK---DERASLQDELREYEERINSMTSHFK 60
E L + + E A + L+ +L L D + L L + + + + + + K
Sbjct: 1402 ENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEK 1461
Query: 61 NVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQR----LENEMASILEKKS 116
N+ + + + +A RE E++ A A E K+E++R L+ EM ++ K
Sbjct: 1462 NISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKD 1521
Query: 117 DKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALT----------------L 160
D + + + L+ QM + LE LE+ DA L
Sbjct: 1522 DVGKNVHELEKSKRALETQMEEMKTQLEE-LEDELQATEDAKLRLEVNMQALKGQFERDL 1580
Query: 161 QKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNER 220
Q +Q++ K R L QL E +RK + A K D + + +
Sbjct: 1581 QARDEQNEEKRRQLQRQLHEYETELEDERK-------QRALAAAAKKKLEGDLKDLELQA 1633
Query: 221 QELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFE 280
IK E I+Q++K + + EL + E KE K +S + + +
Sbjct: 1634 DSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ 1693
Query: 281 KRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIH 340
+ ++ A+R A + + + +L EL S + N + L I+++++++
Sbjct: 1694 EDLAAAER-------ARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746
Query: 341 EETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKG 400
EE ++ + + ++++ + + A E ++ E+ KE+ +L+ ++G
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806
Query: 401 VLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQ 460
+ K + S I + + L Q+++ E + + +D +++
Sbjct: 1807 AVKSKFK-------------STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKE 1853
Query: 461 VERRMS--RLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKA 518
+ ++ R E E+ + A++ +L++ LEE + + +KL +L ++
Sbjct: 1854 ILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATES 1913
Query: 519 HSKNSDEKQSLMTKI 533
+ E +L +K+
Sbjct: 1914 NEAMGREVNALKSKL 1928
Score = 80.9 bits (198), Expect = 5e-15
Identities = 105/482 (21%), Positives = 192/482 (39%), Gaps = 43/482 (8%)
Query: 32 SKLKDERASLQDELREYEERINSMTSHFKNV---KQELSITQSLCKARERETESEEHFKA 88
SK DER + E RE E + S+ + K+EL T + KA + S +
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVG 1524
Query: 89 IAQRELGRVKDEIQRLENEMASILEKKSDK----ENGIFKATQKLDGLKCQMNWDQQALE 144
EL + K ++ EM + LE+ D+ E+ + + LK Q D QA +
Sbjct: 1525 KNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARD 1584
Query: 145 AWLEESAHKDSDALTLQKYAQQDDNKIRALTL--------QLERLTLECNQKRKILDNEL 196
EE + L + +D+ K RAL L+ L L+ + K + +
Sbjct: 1585 EQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAI 1644
Query: 197 TETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDI-----DNCALELARI 251
+ Q ++ ++ R E+ + ++ + + D+ D A E AR
Sbjct: 1645 KQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERAR- 1703
Query: 252 KQETREKENLVKEKIKFLESEIGNNTE---FEKRISVADRKLL-----------KCRTAY 297
KQ EKE L +E L E E RI+ + +L + R A
Sbjct: 1704 KQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKAT 1763
Query: 298 QDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHE-ETARLQKTKNHNEII 356
Q E QL EL + ++T + S + L + +++ +HE E A K K+ +
Sbjct: 1764 QQAE----QLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAAL 1819
Query: 357 QTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKE 416
+ K+ ++ E+ + LK+++K +KE+ +Q+ + + + ++ + +
Sbjct: 1820 EAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARV 1879
Query: 417 KAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEE 476
K + ++E + +N +KL E E S + ++V S+L+G E
Sbjct: 1880 KQLKRQLEEAEEESQRINANRRKLQREL---DEATESNEAMGREVNALKSKLRGPPPQET 1936
Query: 477 KQ 478
Q
Sbjct: 1937 SQ 1938
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 141 bits (355), Expect = 3e-33
Identities = 192/885 (21%), Positives = 391/885 (44%), Gaps = 136/885 (15%)
Query: 6 LAELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQE 65
L+E+ W A + N+EN +E +L+ L RA + + +YE+ +K++
Sbjct: 479 LSEIEWNP--ATKLLNQEN--IESELNSL---RADYDNLVLDYEQLRTEKEEMELKLKEK 531
Query: 66 LSITQSLCKARERETESEEHFKAIAQRELGRVKDEI-------QRLENEMASILEKKSDK 118
+ + +A ER+T+ ++ + I E+ +K+ + Q LENE++S +E +K
Sbjct: 532 NDLDEF--EALERKTKKDQEMQLI--HEISNLKNLVKHAEVYNQDLENELSSKVELLREK 587
Query: 119 ENGIFKA-----TQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRA 173
E+ I K +QKL+ +K +++ +++E ++ DA T+ A+++ +R+
Sbjct: 588 EDQIKKLQEYIDSQKLENIKMDLSYSLESIED-PKQMKQTLFDAETVALDAKRESAFLRS 646
Query: 174 LTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQ 233
L+L+ E K ++N++ + +QLE K Q +L K+ ++ +
Sbjct: 647 ENLELKEKMKELATTYKQMENDI-QLYQSQLEAKKKMQ---------VDLEKELQSAFNE 696
Query: 234 MQKRDGDIDN-------CALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVA 286
+ K ID C LEL + +++ N E+ + L E+ +E + S
Sbjct: 697 ITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEV 756
Query: 287 DRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARL 346
+R R QD + E D L + V S ++ L + I K K D+ +
Sbjct: 757 ER----LRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY 812
Query: 347 QKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKA 406
+ T + +T + +K V E+ + + K+ ++ D L +K L K
Sbjct: 813 KSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKT 872
Query: 407 QELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMS 466
QELQ +T + + L+E+E + L++ + LQ T+++++ + ++ +QQ +
Sbjct: 873 QELQEKTREVQERLNEMEQLKEQLENRDSTLQ-----TVEREKTLITE--KLQQTLEEVK 925
Query: 467 RLKGEINSEEKQALEAKIVELRKSLEEKKSTCGL-LETQIKKLHNDLYFIKKAHSKNSDE 525
L E + KQ E+ +E + + T + ++TQ ++L N L +K+ H + +
Sbjct: 926 TLTQE-KDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQ-EQLRNALESLKQ-HQETINT 982
Query: 526 KQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSL 585
+S +++ NL ++ + E F+Q ++ D LE K T+ + + +
Sbjct: 983 LKSKISEEVSRNLHMEENTGETKDE--FQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIE 1040
Query: 586 EKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEIL 645
++RK +++ ++E+ E L + V E+E + T+ +E + +
Sbjct: 1041 QQRK--IFSLIQEKNE--------LQQMLESVIAEKEQLKTDLKENIE-----------M 1079
Query: 646 TVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSC 705
T+ + +EEL+ GD L K ++EI A E
Sbjct: 1080 TI---------------------ENQEELRLLGDEL-----KKQQEIVAQEK-------- 1105
Query: 706 NNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIE 765
+ KK S + ++EE+ + ++ + KQ+Q+ +QE++ M+ ++ IE
Sbjct: 1106 ----NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE 1161
Query: 766 HLANNVKEK---LSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKE------------- 809
+L N +K K L + +L+++ E +++ +TK+ K+ KE
Sbjct: 1162 NLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKE-RKVLKELQKSFETERDHLR 1220
Query: 810 --IRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEI 852
IR ++ T +T EE I +K+ + IDE+ + E+ +I
Sbjct: 1221 GYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQI 1265
Score = 134 bits (336), Expect = 5e-31
Identities = 194/886 (21%), Positives = 374/886 (42%), Gaps = 133/886 (15%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTS-------HFKNVKQELSITQSLCK 74
EE K L + LK + SLQ E + + I+ + +N + L Q
Sbjct: 922 EEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETIN 981
Query: 75 ARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSD-------------KENG 121
+ + E + G KDE Q+ +M I +KK D K+N
Sbjct: 982 TLKSKISEEVSRNLHMEENTGETKDEFQQ---KMVGI-DKKQDLEAKNTQTLTADVKDNE 1037
Query: 122 IFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERL 181
I + +K+ L + N QQ LE+ + E +D + ++ ++R L +L++
Sbjct: 1038 IIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQ 1097
Query: 182 T-LECNQKRKIL--DNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRD 238
+ +K + + EL+ T E+++ ++ + E+Q+ + + + +MQK+
Sbjct: 1098 QEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKI 1157
Query: 239 GDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQ 298
+I+N EL K + E++ E+++ L ++ N E K I+ +RK+LK +
Sbjct: 1158 NEIENLKNEL---KNKELTLEHMETERLE-LAQKLNENYEEVKSIT-KERKVLK--ELQK 1210
Query: 299 DHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQT 358
ET R L+G + ++AT +T +L+ ++ K H E I
Sbjct: 1211 SFETERDHLRGYIREIEATGLQTKEELKIAHIHL-----------------KEHQETIDE 1253
Query: 359 KLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDV---QLNLIKGVLFKKAQELQTETMK 415
+ ++EKT + N +D+ K K +E+ V + L+ V K+ E Q ETM
Sbjct: 1254 LRRSVSEKTAQI----INTQDLEKSHTKLQEEIPVLHEEQELLPNV--KEVSETQ-ETMN 1306
Query: 416 EKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSE 475
E +L+E T+ S L +++ E L+ E I+ + + LK
Sbjct: 1307 ELELLTEQSTTKDSTT-----LARIEMERLRLNEKFQESQEEIKSLTKERDNLK-----T 1356
Query: 476 EKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKI-N 534
K+ALE K +L++ + E + + E+Q K+ S N EK + TKI +
Sbjct: 1357 IKEALEVKHDQLKEHIRE--TLAKIQESQSKQ----------EQSLNMKEKDNETTKIVS 1404
Query: 535 ELNLF---------IDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSL 585
E+ F I+ L K D M K +++R +E+L S++++ L
Sbjct: 1405 EMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQ---L 1461
Query: 586 EKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENIS---TEFRERLSKIEKLKNRY 642
++ +++ E EE+KV L Q +++ R N+S TE ++E + ++
Sbjct: 1462 KENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKL 1521
Query: 643 EILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVL 702
+ + E + Q V + E ++ + D+ + E ++ L N LQ
Sbjct: 1522 QNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQ-- 1579
Query: 703 NSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDI-----QSM 757
S +E ++ I+ +E+ + V E + ++ Q++E ++I +S
Sbjct: 1580 ---------------ESQEEIQIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQ 1624
Query: 758 ENTLDVIEHLA-NNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTK-------E 809
E ++ A N +EK+ E + L ++ E QK LE + + +LT+ E
Sbjct: 1625 EKEYQFLKMTAVNETQEKMCEIE----HLKEQFETQKLNLENIETENIRLTQILHENLEE 1680
Query: 810 IRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRII 855
+R + +D+ ++ E Q + + E + +E+ E++I+
Sbjct: 1681 MRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIV 1726
Score = 130 bits (327), Expect = 6e-30
Identities = 177/910 (19%), Positives = 399/910 (43%), Gaps = 150/910 (16%)
Query: 29 DQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKA 88
++L + E+ L E+ E R+ + K +L+ TQS K+ ++E ++ +
Sbjct: 768 EELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHM 827
Query: 89 IAQRELGRVKDEIQRLENEMASILEK--KSDKENGIFKA-----TQKLDGLKCQMNWDQQ 141
+++ V +E +R+ E+ ++ ++ K D G K TQ+L ++
Sbjct: 828 DFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLN 887
Query: 142 ALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETIS 201
+E E+ ++DS T+++ K++ +++ LT E + +++ + S
Sbjct: 888 EMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQE-------S 940
Query: 202 AQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELAR-IKQETREKEN 260
Q+E D+ D N + +Q N +E +++ I+ +++ + + +EN
Sbjct: 941 LQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEEN 1000
Query: 261 LVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHET--------SRIQLKGELD 312
+ K +F + +G +K+ + + +D+E S IQ K EL
Sbjct: 1001 TGETKDEFQQKMVG----IDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQ 1056
Query: 313 S---------------LKATVNRTSSDLEALR----------------KN---------- 331
LK + T + E LR KN
Sbjct: 1057 QMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELS 1116
Query: 332 -----ISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEK 386
++++++ + E++ +LQ+ + +Q ++ E+ +K +E NL++ LK +E
Sbjct: 1117 RTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIE----NLKNELKNKEL 1172
Query: 387 DVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGT-RSSLKHLNHQLQKLDFETL 445
++ ++ + + L + +E+++ T KE+ VL E++ + + HL +++++ L
Sbjct: 1173 TLEHMETERLELAQKLNENYEEVKSIT-KERKVLKELQKSFETERDHLRGYIREIEATGL 1231
Query: 446 KQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQI 505
+ +E + H+++ + + L+ ++ + Q + + +L KS + L+ +I
Sbjct: 1232 QTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ--DLEKSHTK-------LQEEI 1282
Query: 506 KKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLK 565
LH + + K E Q M NEL L ++S + L +
Sbjct: 1283 PVLHEEQELLPNV--KEVSETQETM---NELELLTEQSTTK------------DSTTLAR 1325
Query: 566 LEVKRTR--EMLHSKAEEVLSLEKRKQQLYT---AMEERTEEIKVHKTMLASQIRYVDQE 620
+E++R R E EE+ SL K + L T A+E + +++K H ++I+ Q
Sbjct: 1326 IEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQ-ESQS 1384
Query: 621 RENISTEFRER-------LSKIEKLKNRYEILTVVMLPPEGEEEKTQAYY--VIKAAQEK 671
++ S +E+ +S++E+ K + L + + G ++ Q + + A+EK
Sbjct: 1385 KQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK 1444
Query: 672 EELQREGDCLDAKINKAE---KEIYA----LENTLQVLNSCNNNYKQSFKKVTPSSDEYE 724
++LQR + L ++ ++ + KEI A E L+V + C +++ ++ + E E
Sbjct: 1445 DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKE 1504
Query: 725 LKIQ-LEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSF 783
+I +++Q A+++K + K ++I E +E + + V+EK++E +
Sbjct: 1505 TEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQ---------ISEVQEKVNELK---- 1551
Query: 784 QLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLV 843
Q + + + L+ + + +LT ++ E+ EE I ++E ++ +V + + +
Sbjct: 1552 QFKEHRKAKDSALQSIESKMLELTNRLQ-------ESQEEIQIMIKEKEEMKRVQEALQI 1604
Query: 844 --DIIEENTE 851
D ++ENT+
Sbjct: 1605 ERDQLKENTK 1614
Score = 126 bits (316), Expect = 1e-28
Identities = 178/872 (20%), Positives = 391/872 (44%), Gaps = 101/872 (11%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETE 81
+E++ D+L + E+ + ++ E+ + + +E + ++ + E + E
Sbjct: 1245 KEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQ-E 1303
Query: 82 SEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQ 141
+ + + ++ + + R+E E + EK + + I T++ D LK ++
Sbjct: 1304 TMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTI----KE 1359
Query: 142 ALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETIS 201
ALE ++ K+ TL K + + ++L N K K DNE T+ +S
Sbjct: 1360 ALE--VKHDQLKEHIRETLAKIQESQSKQEQSL-----------NMKEK--DNETTKIVS 1404
Query: 202 AQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENL 261
+ +I E L K+ + + ++M+ + D +L R+++ + + +
Sbjct: 1405 EMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKD----DLQRLQEVLQSESDQ 1460
Query: 262 VKEKIKFLESEIGNNTEFEKRISVA-------DRKLLKCRTAYQDHETSRIQLKGELDSL 314
+KE IK + + + E E+ + VA + + + R + ET ++ +L+++
Sbjct: 1461 LKENIKEI---VAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAI 1517
Query: 315 KATVNRTSSDLEALRK--NISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEK----TM 368
+ ++ + NI +I ++ E+ L++ K H + + L+ I K T
Sbjct: 1518 NDKLQNKIQEIYEKEEQFNIKQIS-EVQEKVNELKQFKEHRKAKDSALQSIESKMLELTN 1576
Query: 369 SVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVL----------FKKAQELQTETMKEKA 418
++E ++ M+KE+E ++K V L + + L K++QE + + +K A
Sbjct: 1577 RLQESQEEIQIMIKEKE-EMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTA 1635
Query: 419 VLSEIEGTRSSLKHLNHQL--QKLDFETLKQQEIMYSQDFHIQQVERR-MSRLKGEINSE 475
V +E + ++HL Q QKL+ E ++ + I +Q H E R +++ + ++ S
Sbjct: 1636 V-NETQEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSV 1694
Query: 476 EKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMT-KIN 534
E + L+ + +L+++L E + + ++K +H L K H + D+ + +++ K N
Sbjct: 1695 E-ETLKVERDQLKENLRETITRDLEKQEELKIVHMHL----KEHQETIDKLRGIVSEKTN 1749
Query: 535 ELNLFIDRSEKELDKAKGFKQDLMIEDNL------LKLE---VKRTREMLHSKAEEVLSL 585
E++ E D K QDL I++ L LK + + + R ++ K +++ ++
Sbjct: 1750 EISNMQKDLEHSNDALKA--QDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNM 1807
Query: 586 EKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQ------ERENISTEFRERLSKIEKLK 639
+K + ++E+ +E+K ++ L + + V++ E E + + +++ + KL+
Sbjct: 1808 QKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE 1867
Query: 640 NRYEILTVVMLPPEG-EEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENT 698
E L + E EE K+ + +E L+ E D L + + + ++
Sbjct: 1868 --IENLNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQE 1925
Query: 699 LQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQE-DIQSM 757
L+ + +K++ K+ E IQ+ + ++ +D+ Q++I+ELQ+ ++Q +
Sbjct: 1926 LKTARMLSKEHKETVDKLREKISEKT--IQISDIQKDLDKSKDELQKKIQELQKKELQLL 1983
Query: 758 ENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTK-------EI 810
DV N +K++E + QL K+ E Q ++ V +LTK EI
Sbjct: 1984 RVKEDV-----NMSHKKINEME----QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEI 2034
Query: 811 RLLKDTKDETMEEQDIKLREMKQFHKVIDEML 842
R++ +DE ++ E QF + EM+
Sbjct: 2035 RIVAKERDELRRIKESLKMERDQFIATLREMI 2066
Score = 105 bits (262), Expect = 2e-22
Identities = 180/863 (20%), Positives = 368/863 (42%), Gaps = 104/863 (12%)
Query: 12 EDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQS 71
E+ F I +E + + ++L + K+ R + L+ E ++ +T+ + ++E+ I
Sbjct: 1532 EEQFNIKQISEVQEKV-NELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIM-- 1588
Query: 72 LCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKAT--QKL 129
+ +E K + Q L +D+++ E+ + +++ +KE K T +
Sbjct: 1589 --------IKEKEEMKRV-QEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET 1639
Query: 130 DGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERL-----TLE 184
C++ ++ E + +++ + L + ++ ++R++T + + L TL+
Sbjct: 1640 QEKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLK 1699
Query: 185 CNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNC 244
+R L L ETI+ LE + + E QE I + + + + +I N
Sbjct: 1700 V--ERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSE---KTNEISNM 1754
Query: 245 ALELARIKQETREKENLVKEKIKFLESEIGNNTE-FEKRISVADRKLLKCRTAYQDHETS 303
+L + ++ ++E+++ + E +K + K K +D E S
Sbjct: 1755 QKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENS 1814
Query: 304 RIQLKGELDSLKATVNRT---SSDLEALRKNISK---IKKDIHEETARLQKTKNHNEIIQ 357
+L+ ++ LKA ++ D+ +K +S+ +KK I +++ L K + N +
Sbjct: 1815 NAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLA 1874
Query: 358 TKLKEITEKTMSVEEKATNL---EDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETM 414
KL E E+ SV ++ NL E+ LK E +KE L K + QEL+T M
Sbjct: 1875 QKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKE---SLQETKARDLEIQQELKTARM 1931
Query: 415 KEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINS 474
K ++ R + Q+ + + K ++ + + +Q+ E ++ R+K ++N
Sbjct: 1932 LSKEHKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNM 1991
Query: 475 EEKQALEAKIVELRKSLEEKKSTCGLLETQ----IKKLHNDLYFIKKAHSKNSDE----K 526
K+ E + +L+K E + + + KKLH L I+ +K DE K
Sbjct: 1992 SHKKINEME--QLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIV-AKERDELRRIK 2048
Query: 527 QSLMTK----INELNLFIDRS--------EKEL--DKAKGFKQDLMIEDNLLKLEVKRTR 572
+SL + I L I R EK L D + + L + + +K +KR
Sbjct: 2049 ESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKRYS 2108
Query: 573 EM-LHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQ---ERENISTEF 628
EM H + LSL+ K+ + +E + +K + ++ Q +++++ + S EF
Sbjct: 2109 EMDDHYECLNRLSLDLEKEIEF--QKELSMRVKANLSLPYLQTKHIEKLFTANQRCSMEF 2166
Query: 629 RERLSKIEKLKNRYEILTVVMLPPEGEE--EKTQAYYVIKAAQEKEELQR----EGDC-- 680
+ K+ +Y + V + E E K + ++ + ++KE L + + DC
Sbjct: 2167 HRIMKKL-----KYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDV 2221
Query: 681 -----LDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRA 735
D K+N+ +++ E S + K F++V S+ E+ LEE
Sbjct: 2222 PSRELRDLKLNQ-NMDLHIEEILKDFSESEFPSIKTEFQQVL--SNRKEMTQFLEE---- 2274
Query: 736 VDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANN----VKEKLSEKQAYSFQLSKETEE 791
+ + I +L+ IQ + + + + NN + + +E + S +SKE E+
Sbjct: 2275 ----WLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQ 2330
Query: 792 QKPKLERVTKQCAKLTKEIRLLK 814
L+ + ++ KL K + LK
Sbjct: 2331 D---LKSLKEKNEKLFKNYQTLK 2350
Score = 98.2 bits (243), Expect = 3e-20
Identities = 155/773 (20%), Positives = 312/773 (40%), Gaps = 108/773 (13%)
Query: 155 SDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFR 214
+D L++Y ++ I L QLE ++LE + D +L + + + L K +
Sbjct: 340 TDEALLKRYRKE----IMDLKKQLEEVSLETRAQAMEKD-QLAQLLEEKDLLQKVQNE-- 392
Query: 215 KIHNERQELIKQWENTIEQ--MQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESE 272
KI N + L+ T++Q KR + C ++ ++K + + I +
Sbjct: 393 KIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHK 452
Query: 273 IGNNTEFEKRISVADRKLLKCRTAYQDHET---------SRIQLKGELDSLKATVNRTSS 323
+ N E SV + T E ++ ++ EL+SL+A +
Sbjct: 453 LSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVL 512
Query: 324 DLEALRKNISKI------KKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNL 377
D E LR ++ K D+ E A +KTK E M + + +NL
Sbjct: 513 DYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQE-------------MQLIHEISNL 559
Query: 378 EDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQL 437
++++K E V D++ L V + +E Q + ++E ++E + L +
Sbjct: 560 KNLVKHAE--VYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSY----- 612
Query: 438 QKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKST 497
E+++ + M F + V R + SE +EL++ ++E +T
Sbjct: 613 ---SLESIEDPKQMKQTLFDAETVALDAKRESAFLRSEN--------LELKEKMKELATT 661
Query: 498 CGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRS-------------- 543
+E I+ + L KK E QS +I +L ID
Sbjct: 662 YKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGK 721
Query: 544 --------EKELDKAKGFKQDLMIEDNLLKL--EVKRTREMLHSKAEEVLSLEKRKQQLY 593
KE+++ + ++++++ L L EV+R R+ + K+EE+ + K +L+
Sbjct: 722 ITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLF 781
Query: 594 TAMEERT-------EEIKVHKTMLA---SQIRYVDQERENISTEFRERLSKIEKLKNRYE 643
+ + + EEI K LA S + DQE +N T + K + + E
Sbjct: 782 SEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENE 841
Query: 644 ILT--VVMLPPEGEE-EKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQ 700
+ +V L E ++ + + + + + +ELQ + + ++N+ E+ LEN
Sbjct: 842 RMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDS 901
Query: 701 VLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIR-----------E 749
L + +K+ + +E + Q ++ + + E + ++ Q++ +
Sbjct: 902 TLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 961
Query: 750 LQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVT-----KQCA 804
QE +++ +L + N +K K+SE+ + + + + T E K + ++ KQ
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDL 1021
Query: 805 KLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQ 857
+ L D KD + EQ K+ + Q + +ML +I E +++ L+
Sbjct: 1022 EAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLK 1074
Score = 53.5 bits (127), Expect = 9e-07
Identities = 124/653 (18%), Positives = 264/653 (40%), Gaps = 103/653 (15%)
Query: 30 QLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSL----CKARERETESEEH 85
+L K + + +++++ ++IN M K + + QS+ + ++ ES E
Sbjct: 1974 ELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEE 2033
Query: 86 FKAIAQR--ELGRVKDEIQRLENEMASILEKK--SDKENGIFKATQKLDGLKCQMNWDQQ 141
+ +A+ EL R+K+ ++ ++ + L + D++N K ++L ++ QQ
Sbjct: 2034 IRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKPEKRL------LSDGQQ 2087
Query: 142 ALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETIS 201
L L E + + L ++Y++ DD+ L RL+L+ +K EL+ +
Sbjct: 2088 HLTESLREKCSRIKELL--KRYSEMDDHYEC-----LNRLSLDL-EKEIEFQKELSMRVK 2139
Query: 202 AQLELDKA-AQDFRKIHNERQELIKQWENTIEQMQ---------KRDGDIDNCALELARI 251
A L L + K+ Q ++ +++++ K + E+ I
Sbjct: 2140 ANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMDFI 2199
Query: 252 KQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRI-QLKGE 310
+ ++KE L+K I+ L+ + + + + + L +D S +K E
Sbjct: 2200 DEVEKQKELLIK--IQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTE 2257
Query: 311 LDSLKATVNRTSSDLEA---LRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKT 367
+ + + LE R +I K+K I +E R+ + N ++ I ++
Sbjct: 2258 FQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNN---FFNNRIIAIMNES 2314
Query: 368 MSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTR 427
EE++ + +++ K +KE + +L FK Q L+T V + +
Sbjct: 2315 TEFEERSATISKEWEQDLKSLKEKNEKL-------FKNYQTLKTSLASGAQVNPTTQDNK 2367
Query: 428 SSLKHLNHQLQKLDFETLKQQE-IMYSQDFHIQQVERRMSRLKGE--INSEEKQALEAKI 484
+ H+ + +L E +++ E ++ E ++ +++ E + ++ L+AK+
Sbjct: 2368 NP--HVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKV 2425
Query: 485 VELRKSLEEKKSTCGLLETQI-------KKLHNDLYF------IKKAHSKNSDEKQSLMT 531
E K LE+ K T +L+ ++ K+ DL ++K + EK+ T
Sbjct: 2426 HESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISAT 2485
Query: 532 K---------INELNLFIDRSEKELDKA--------------------KGFKQD---LMI 559
K I L + RS++ D + G Q+ L++
Sbjct: 2486 KATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALIL 2545
Query: 560 EDNLLKLE-----VKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHK 607
+ ++LE +K+ E L + E+LS + +ERT + + HK
Sbjct: 2546 KSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKREAHK 2598
Score = 36.6 bits (83), Expect = 0.11
Identities = 58/306 (18%), Positives = 122/306 (39%), Gaps = 50/306 (16%)
Query: 17 IPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKAR 76
I + NE + E + K+ + +L+ +E+ + +++ +K L+ A+
Sbjct: 2308 IAIMNESTEFEERSATISKE----WEQDLKSLKEKNEKLFKNYQTLKTSLA-----SGAQ 2358
Query: 77 ERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLD------ 130
T + + R ++I+ LEN + E KE+ I K ++L+
Sbjct: 2359 VNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDII 2418
Query: 131 -GLKCQMNWDQQALEAWLEE-SAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQK 188
L+ +++ + LE E +D AL + Y ++ I L ++L ++ LE +
Sbjct: 2419 AKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEE----IEDLKMKLVKIDLEKMKN 2474
Query: 189 RKILDNELT---ETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKR-------D 238
K + E++ T+ Q E+ + ++ + + Q+ E+T Q +
Sbjct: 2475 AKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGS 2534
Query: 239 GDIDNCAL------------ELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVA 286
G + N E++++KQ + E L+K+K + L NN +
Sbjct: 2535 GIVQNTKALILKSEHIRLEKEISKLKQ---QNEQLIKQKNELL----SNNQHLSNEVKTW 2587
Query: 287 DRKLLK 292
+ LK
Sbjct: 2588 KERTLK 2593
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 136 bits (343), Expect = 8e-32
Identities = 193/942 (20%), Positives = 391/942 (41%), Gaps = 153/942 (16%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETE 81
E + L+++LS+++ + L+ E ++ +++ H ++ E++ S ER+
Sbjct: 372 EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQL- 430
Query: 82 SEEHFKAIAQRELGRVK-----DEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQM 136
E H + QR+L K ++ L+ +++ + E+ +K + +LD K Q
Sbjct: 431 GEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTK-QQ 489
Query: 137 NWDQQAL---------------EAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERL 181
+ +QQAL E L + KD L+ Q+ I L + E L
Sbjct: 490 HQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDL 549
Query: 182 --TLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDG 239
++ + + N+L E E + Q K+ N+ + + EN +Q+Q++
Sbjct: 550 YAKIQAGEGETAVLNQLQEKNHTLQE--QVTQLTEKLKNQSESHKQAQENLHDQVQEQKA 607
Query: 240 DI---DNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTA 296
+ + L L E + N KEK+ L+ +I TE LL A
Sbjct: 608 HLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTEL----------LLSAEAA 657
Query: 297 YQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEII 356
R L+ LD+ + + L+ ++ ++KI + + TA+LQ + H +
Sbjct: 658 ---KTAQRADLQNHLDTAQ-------NALQDKQQELNKITTQLDQVTAKLQDKQEHCSQL 707
Query: 357 QTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDV----------QLNLIKGVLFKKA 406
++ LKE EK +S+E+K LE +K+ E D EV Q + L +A
Sbjct: 708 ESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRA 767
Query: 407 QELQTETMKEKAVLSE-----------IEGTRSSL--KHLNHQLQKLDFETLKQQEIMYS 453
EL + EK ++S +E + L + Q+ K DFETL Q+ +
Sbjct: 768 TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 454 QDFH---------IQQVERRMSRLKGEINS--------------------EEKQALEAKI 484
++ + +Q+V+ L E+++ +E Q +A I
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAI 887
Query: 485 V-------------------------ELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAH 519
+ EL+KSLE++K L+ ++ + L +
Sbjct: 888 LDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTL 947
Query: 520 SKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIE----DNLLKLEVKRTREML 575
+N E+Q L INEL ++ +K+++ +G + +++ +N L+ ++ + + L
Sbjct: 948 KQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQEL 1007
Query: 576 HSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKI 635
++ E++ L+ ++ ++ + ++ L + + + E +S + +S
Sbjct: 1008 AAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNR 1067
Query: 636 EKLKNRYEIL-----TVVMLPPEGEEEKTQAYYVIKAAQ--EKEELQREGDCLDAKINKA 688
++ N+ +++ L + +++ Q KA Q +KE+ +E + ++ K A
Sbjct: 1068 NQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLA 1127
Query: 689 EKEIYAL--ENTLQVLNSCNNNYK-QSFKKVTPSSDEYELKIQ--LEEQKRAVDEKYRYK 743
E E E + LN ++K +S K++T D +L IQ LE Q +A K +
Sbjct: 1128 EIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVE 1187
Query: 744 QRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQC 803
Q + ++ + D ++ +K++ EK+A +L E +E++ +++ +
Sbjct: 1188 QEK--------RNQQILKDQVKKEEEELKKEFIEKEA---KLHSEIKEKEVGMKKHEENE 1236
Query: 804 AKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDI 845
AKLT +I L + +E R + + K D++ +I
Sbjct: 1237 AKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEI 1278
Score = 135 bits (341), Expect = 1e-31
Identities = 205/965 (21%), Positives = 396/965 (41%), Gaps = 159/965 (16%)
Query: 28 EDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSI-TQSLCKARERETESEEHF 86
E + KLKDE LQ + E I+ + S QE+++ Q L K + E +
Sbjct: 245 ERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKN 304
Query: 87 KAIAQRELGRVKD--EIQRLENE--------MASILEKKSD------------------- 117
+ + + L + +D +++ NE A++ +K D
Sbjct: 305 QTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIH 364
Query: 118 ---KENGIFKATQKLDGLKCQMNWDQQALEAWL----EESAHKDSDALTLQKYAQQDDNK 170
E G +ATQKL ++ Q L+A ++ K+ L LQ Q +K
Sbjct: 365 VELSEKG--EATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSK 422
Query: 171 IRALTLQL---------------------ERLTLECNQKRKILDNELTETISAQLELDKA 209
+ QL E+ + K L+ +L E ++ EL
Sbjct: 423 LLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQ 482
Query: 210 AQDFRKIHNERQEL-------IKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLV 262
++ H E+Q L +++ +N +EQ+ ++ GD D L + Q+++E +L+
Sbjct: 483 LDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLL 542
Query: 263 KE-------KIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLK 315
++ KI+ E E + +++ ++ + ++ S Q + ++L
Sbjct: 543 EKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQ---ENLH 599
Query: 316 ATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKAT 375
V + L A + + ++ ++E ++L ++K + ++K TE +S E T
Sbjct: 600 DQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659
Query: 376 -----------NLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIE 424
++ L+++++++ ++ QL+ + L K + K +
Sbjct: 660 AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719
Query: 425 GTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKI 484
+ L Q++KL+ ++L E+ S++ +Q ++++ ++N++ LE +
Sbjct: 720 SLEQKTEELEGQIKKLEADSL---EVKASKEQALQDLQQQR-----QLNTD----LELRA 767
Query: 485 VELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLM---------TKI-- 533
EL K LE +K ++K L IK+ +K +EKQ L TKI
Sbjct: 768 TELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKIQH 827
Query: 534 NELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLY 593
ELN I + EL K K K+ LM E + +K ++ + + L + E EK Q+
Sbjct: 828 EELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSE---FEKENQKGK 884
Query: 594 TAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPE 653
A+ + + K K L Q+ EN E +E +EK K L + +
Sbjct: 885 AAILDLEKTCKELKHQLQVQM-------ENTLKEQKELKKSLEKEKEASHQLKLEL--NS 935
Query: 654 GEEEKTQAYYVIKAAQEKEELQREGDCLDAK--INKAEKEIYALENTLQVLNSCNNNYKQ 711
+E+ QA +K EKEE Q +G+ + K + +K+I AL+ L++ +
Sbjct: 936 MQEQLIQAQNTLK-QNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELEN 994
Query: 712 SF-KKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANN 770
+++T ++ E + +E+ + Y Q ++LQ D E+ L +
Sbjct: 995 KLQQQLTQAAQELAAE---KEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKS 1051
Query: 771 VKEKLS----------------EKQAYSFQLSKET-EEQKPKLERVTKQCAKLTKEIRLL 813
V+EKLS K + +K T E+ K E+ ++ K ++I+
Sbjct: 1052 VEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE 1111
Query: 814 KDTKDETM--------EEQDIKLREMKQFHKVIDEM---LVDIIEENTEIRIILQTYFQQ 862
K K++ + E ++IK R+ K+ K+ +E+ ++ I+E T ++ Q QQ
Sbjct: 1112 KSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQ 1171
Query: 863 SGLEL 867
LEL
Sbjct: 1172 K-LEL 1175
Score = 113 bits (283), Expect = 7e-25
Identities = 177/907 (19%), Positives = 376/907 (41%), Gaps = 121/907 (13%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQ----------- 70
E+ +L ++L + + A LQ +L EE++ ++ ++ +L T+
Sbjct: 439 EQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQ 498
Query: 71 -SLCKARERETESEEHFKAIAQRE---------LGRVKDEIQRLENEM------------ 108
+ K RE + + E+ + I ++ L + K+ I LE E
Sbjct: 499 STTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEG 558
Query: 109 -ASILEKKSDKENGIFK-ATQKLDGLKCQMNWDQQALEAW----LEESAH---KDSDALT 159
++L + +K + + + TQ + LK Q +QA E E+ AH L+
Sbjct: 559 ETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618
Query: 160 LQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNE 219
L+ + ++++ ++ +L ++ K ++L + + + +L + +
Sbjct: 619 LETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQD 678
Query: 220 RQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEI----GN 275
+Q+ + + ++Q+ + D +L +E +EK +++K + LE +I +
Sbjct: 679 KQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEAD 738
Query: 276 NTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKI 335
+ E + A + L + R D E +L +L+ K V+ T DL+ + + I
Sbjct: 739 SLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESI 798
Query: 336 KKDIHEETARLQKTKNHNEIIQTKLK-EITEKTMSVEEKATNLEDMLKEEEKDVKEVDV- 393
K+ + ++ Q K E + + K + E ++ T L+ + E+E + E+
Sbjct: 799 KQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTV 858
Query: 394 --QLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIM 451
+L+ + L E + E K KA + ++E T K L HQLQ TLK+Q+ +
Sbjct: 859 KDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKT---CKELKHQLQVQMENTLKEQKEL 915
Query: 452 YSQDFHIQQVERRMSRLKGEINS----------------EEKQALEAKIVELRKSLEEKK 495
+++ + +LK E+NS +E+Q L+ I EL++S E+KK
Sbjct: 916 KKS---LEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKK 972
Query: 496 STCGLLETQIK-KLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFK 554
L+ ++K + K + + Q L + ++++ + EK + K +
Sbjct: 973 KQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQ 1032
Query: 555 QDLMIEDNLL---KLEVKRTREMLHSKAEEVLS-------LEKRKQQLYTAMEERTEEIK 604
D ++ L + ++K E L E+++S K Q+L TA ++
Sbjct: 1033 SDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSA 1092
Query: 605 VHKTMLASQIRYVDQERENISTEFRE------RLSKIEKLKNRYEILTVVMLPPEGEEEK 658
+ L + + + ++ S + +E +L++IE++K R E + L E + K
Sbjct: 1093 KKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQE-KEITKLNEELKSHK 1151
Query: 659 TQAYYVIK--------AAQEKEELQREGDCLDAKINKAEKEIYALENTLQV--------- 701
++ I Q+K ELQ + D L A + + ++ L++ ++
Sbjct: 1152 LESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEF 1211
Query: 702 ------LNSCNNNYKQSFKKVTPSSDEYELKIQ-LEEQKRAVDEKYRYKQRQIRELQEDI 754
L+S + KK + + ++I L E V ++++ QR++ EL++
Sbjct: 1212 IEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQT 1271
Query: 755 QSMENTLDVIEHLANN-------VKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLT 807
+ + V+E N + E+ + + +L + E + KL+ T +L
Sbjct: 1272 DDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELG 1331
Query: 808 KEIRLLK 814
+E + L+
Sbjct: 1332 RENQSLQ 1338
Score = 101 bits (252), Expect = 3e-21
Identities = 157/782 (20%), Positives = 321/782 (41%), Gaps = 141/782 (18%)
Query: 88 AIAQRELGRVKDEIQRLENEM------ASILEKKSDKENGIFKATQKLDGLKCQMNWDQQ 141
A+ + ++ ++ E+Q L+ + + L+K+ +K G+ + K DGL + + Q
Sbjct: 79 ALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQ 138
Query: 142 ALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETIS 201
+LE LEE AQ ++ I+ + +L E +
Sbjct: 139 SLEQQLEE--------------AQTENFNIKQM-------------------KDLFEQKA 165
Query: 202 AQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENL 261
AQL + A D + ++E + L + E + ++ + +++ A + +K E ++ +
Sbjct: 166 AQLATEIA--DIKSKYDEERSLREAAEQKVTRLTE---ELNKEATVIQDLKTELLQRPGI 220
Query: 262 VKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRT 321
E + L+ E+ V + L+ T ++ E+ + LK E L++ +
Sbjct: 221 --EDVAVLKKEL-----------VQVQTLMDNMTLERERESEK--LKDECKKLQSQYASS 265
Query: 322 SSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDML 381
+ + LR ++K +++ LQK K+ + K + +TE + E+ T LE+
Sbjct: 266 EATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKH 325
Query: 382 KEE--------------EKDVKEVDVQLNLIKGVLFKKAQELQTE---TMKEKAVLSEIE 424
EE + D +++ +L+ + L + EL + T K K LSE+E
Sbjct: 326 NEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVE 385
Query: 425 ----GTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQAL 480
++ K L Q ++ + L+ Q + + + ER++ G + E++Q
Sbjct: 386 TKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRL-KEQRQLS 444
Query: 481 EAKIVELRKSLEEKKSTCGLLETQIK-------KLHNDLYFIKKAHSKNSDEKQSLMTKI 533
K+++ + + + + LE Q+K +L + L K+ H + +QS K+
Sbjct: 445 SEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKL 504
Query: 534 NELNLFIDRSEKEL-DKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQL 592
E +++ +++ DK + +++ +L E + LEK ++ L
Sbjct: 505 REAQNDLEQVLRQIGDKDQ---------------KIQNLEALLQKSKENISLLEKEREDL 549
Query: 593 YTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPP 652
Y ++ E T + +Q+ QE+ + E +L+ EKLKN+ E
Sbjct: 550 YAKIQAGEGE-----TAVLNQL----QEKNHTLQEQVTQLT--EKLKNQSE--------- 589
Query: 653 EGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQS 712
Q +E L + A + A+ + +LE ++ LNS N K+
Sbjct: 590 -------------SHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKE- 635
Query: 713 FKKVTPSSDEYELKIQLEEQKRAVDEKYRYK-QRQIRELQEDIQSMENTLDVIEHLANNV 771
KV+ + + K +L A R Q + Q +Q + L+ I + V
Sbjct: 636 --KVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQV 693
Query: 772 KEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREM 831
KL +KQ + QL +E K K + ++ +L +I+ L+ E ++ L+++
Sbjct: 694 TAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDL 753
Query: 832 KQ 833
+Q
Sbjct: 754 QQ 755
Score = 94.7 bits (234), Expect = 3e-19
Identities = 139/727 (19%), Positives = 319/727 (43%), Gaps = 111/727 (15%)
Query: 22 EENKLLEDQLSKLKDE----RASLQDELREYEER--INS-----MTSHFKNVKQELSITQ 70
++ + LE Q+ KL+ + +AS + L++ +++ +N+ T K ++ E I
Sbjct: 723 QKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVS 782
Query: 71 SLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLD 130
S ++++E+ E K ++L + ++E Q L+ + ++ ++ + + Q
Sbjct: 783 STRLDLQKKSEALESIK----QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTV 838
Query: 131 GLKCQMNWDQQALEAWL---EESAHKDSDALTLQKYAQQDDN-KIRALTLQLERLTLECN 186
++ +++AL L ++ K SD+L K + +N K +A L LE+ E
Sbjct: 839 TELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELK 898
Query: 187 QKRKI-LDNELTET--ISAQLELDKAAQDFRKIH-NERQELIKQWENTIEQMQKRDGDID 242
+ ++ ++N L E + LE +K A K+ N QE + Q +NT++Q +K + +
Sbjct: 899 HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQ 958
Query: 243 NCALELARIKQETREKENLVKEKIKFL---ESEIGNN-----TEFEKRISVADRKLLKCR 294
EL + ++ +++ ++ ++K ++E+ N T+ + ++ K+ +
Sbjct: 959 GNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQ 1018
Query: 295 TAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNE 354
Y+ + + QL+ + ++ + T DL+++ + +S ++D+ + + N N+
Sbjct: 1019 NNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDL---ISNRNQIGNQNK 1075
Query: 355 IIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETM 414
+IQ E+ ++E+ + E L+E K ++++ + +L + E +
Sbjct: 1076 LIQ----ELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSL-----------KEKELV 1120
Query: 415 KEKAVLSEIEGTR----SSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKG 470
EK+ L+EIE + + LN +L+ E++K+ ++ LK
Sbjct: 1121 NEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKE-----------------ITNLKD 1163
Query: 471 --EINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQS 528
++ ++K L+ K L+ ++E++K +L+ Q+KK +L K+
Sbjct: 1164 AKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEEL-------------KKE 1210
Query: 529 LMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKR 588
+ K +L+ I E + K + + L ++ L + ++ S V LEK
Sbjct: 1211 FIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK- 1269
Query: 589 KQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVV 648
+T++++ +L + ++ ER + + +IEKL+ +
Sbjct: 1270 ----------QTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTK------- 1312
Query: 649 MLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNN 708
+L + + + T A +EL RE L K +A +A +N +Q +C
Sbjct: 1313 VLELQRKLDNTTA--------AVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKG 1364
Query: 709 YKQSFKK 715
+ + ++
Sbjct: 1365 FSVTVRR 1371
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 136 bits (343), Expect = 8e-32
Identities = 205/955 (21%), Positives = 403/955 (42%), Gaps = 174/955 (18%)
Query: 27 LEDQLSKLKDERASLQDELREYEER---INSMTSHFKNVKQELSITQSLCKARERETESE 83
LE++LS + ER L+ EL ++ ++ ++ K QEL QS C
Sbjct: 1949 LEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECL--------- 1999
Query: 84 EHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQAL 143
H +A+ E+ + +Q L ++++ +L+ K+ + +
Sbjct: 2000 -HCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKL--------------------- 2037
Query: 144 EAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQ 203
+S KDS AL+L K + +N+I L + E L E L L+E+ +
Sbjct: 2038 -----QSLEKDSQALSLTKC--ELENQIAQLNKEKELLVKESES----LQARLSESDYEK 2086
Query: 204 LELDKAAQ-------DFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELA-RIKQET 255
L + KA + +F + QE + Q IE+++ R + L +A ++K+
Sbjct: 2087 LNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERE 2146
Query: 256 REKENLVKEKIKFLESEIGNNTEFEKRI------SVADRKLLKCRT-----AYQDHETSR 304
RE ++L K+K++ LE E+ + E ++ + S A+ + LK + + + E
Sbjct: 2147 RENDSL-KDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFELDL 2205
Query: 305 IQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHE-ETARLQ---KTKNHNEIIQTKL 360
+ L+ E ++L + L L K +S K + E E A +Q ++K E++Q +L
Sbjct: 2206 VTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQL 2265
Query: 361 KEITEKTMSV---EE--KAT--NLEDMLKEEEK------------------------DVK 389
KE+ E ++ +E KAT +L+ ++EE + +K
Sbjct: 2266 KELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLK 2325
Query: 390 EVDVQLNLIKGVLFKKAQELQ-TETMKEKAVLS------EIEGTRSSLKHLNHQLQKLDF 442
E + +L+KG + +EL+ T +E A L E+E ++ ++ + L+ L+
Sbjct: 2326 ESEHHADLLKGRVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLEL 2385
Query: 443 ETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLE 502
+ + + + +Q+ + R+S L+ INS + L+ K E + E+ + +L+
Sbjct: 2386 DVVTIRSEKENLTNELQKEQERISELE-IINSSFENILQEKEQEKVQMKEKSSTAMEMLQ 2444
Query: 503 TQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDN 562
TQ+K+L+ + + ++Q+L +++ L L + + LD+AK L N
Sbjct: 2445 TQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVN 2504
Query: 563 LLKLEVKRTREMLHSKAEEVLSLEKR---KQQLYTAM----------EERTEEIKVHKTM 609
L EV+ ++ L K EE+ L+ + ++QL + + +E+ E++
Sbjct: 2505 GLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVE 2564
Query: 610 LASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTV----------VMLPPEGEEEKT 659
L +I+ + + ++ S + L+N E+ + M E E ++
Sbjct: 2565 LEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQRE 2624
Query: 660 QAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFK----- 714
K A+ +EEL E + L ++ +EI + ++ L+ L N+ K+S
Sbjct: 2625 MHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKD 2684
Query: 715 ------KVTPSSDEYELKIQLEEQKRA-----VDEKYRYKQRQIRE-------------- 749
KV EY+L++ E+K +++Y + + RE
Sbjct: 2685 QVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKL 2744
Query: 750 ----LQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAK 805
L+ + + N+L + +K+ + Y QL KE E + K++ + K C +
Sbjct: 2745 EIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQ 2804
Query: 806 LTKEIRLLK---------DTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTE 851
L +E +L+ K +T D K+ E+ K + E L + +E E
Sbjct: 2805 LEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDELTTEIKELKETLEEKTKEADE 2859
Score = 106 bits (265), Expect = 9e-23
Identities = 155/746 (20%), Positives = 337/746 (45%), Gaps = 98/746 (13%)
Query: 25 KLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEE 84
K+ E L L+ E+ +L +++E + +++ + + K L E + ++E
Sbjct: 2199 KVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLL----------EEKEQAEI 2248
Query: 85 HFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKAT-QKLDGL---KCQMNWDQ 140
K ++ + ++++++ L +A++ D+E I KAT Q LD + Q+
Sbjct: 2249 QIKEESKTAVEMLQNQLKELNEAVAALC---GDQE--IMKATEQSLDPPIEEEHQLRNSI 2303
Query: 141 QALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLT--LECNQKRKILDNELT- 197
+ L A LE K L K ++ + ++ LER NQ+ L+ E +
Sbjct: 2304 EKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAENSK 2363
Query: 198 ---ETISAQLE-----LDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELA 249
ET+ A++E L D I +E++ L N +++ Q+R +++
Sbjct: 2364 GEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLT----NELQKEQERISELEIINSSFE 2419
Query: 250 RIKQETREKENLVKEK----IKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRI 305
I QE +++ +KEK ++ L++++ E +R++ C+ Q+ +
Sbjct: 2420 NILQEKEQEKVQMKEKSSTAMEMLQTQL---KELNERVAALHNDQEACKAKEQNLSSQVE 2476
Query: 306 QLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITE 365
L+ E L ++ ++ L+ +++ + +++ + +L+K ++ ++++ E
Sbjct: 2477 CLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQD-QE 2535
Query: 366 KTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEG 425
+ +S + + KE+ +++ + V+L Q++Q K ++ +E
Sbjct: 2536 QLVSKLSQVEGEHQLWKEQNLELRNLTVELE----------QKIQVLQSKNASLQDTLEV 2585
Query: 426 TRSSLKHLNHQLQ--KLD-FETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEA 482
+SS K+L ++L+ K+D +++ M +++ +Q+ M++ E+ E
Sbjct: 2586 LQSSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNR 2645
Query: 483 KIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKA----HSKNSDEKQSLMTKINELNL 538
EL+ LEE KS+ + Q+K+L + +KK+ H +++ + +I E L
Sbjct: 2646 LAGELQLLLEEIKSS----KDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQL 2701
Query: 539 FIDRSEKELDKAKGFKQDLMIEDNL-LKLEVKRTREMLHSKAE-------EVLSLEKRKQ 590
+ +EK+ Q L+++ N ++E++ RE L SK E E+ L+ K+
Sbjct: 2702 RLHEAEKK-------HQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLKSSKE 2754
Query: 591 QLYTAMEERTEEIKVHKTMLASQIRYVDQ---ERENISTEFRERLSKIEKLKNRYEILTV 647
+L +++ T+ ++ K ++YV+Q E E + + + ++L+ EIL
Sbjct: 2755 ELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEIL-- 2812
Query: 648 VMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNN 707
++E +Q ++AAQEK Q+ G +D K+++ EI L+ TL+ +
Sbjct: 2813 -------QKELSQ----LQAAQEK---QKTGTVMDTKVDELTTEIKELKETLEEKTKEAD 2858
Query: 708 NYKQSFKKVTPSSDEYE-LKIQLEEQ 732
Y + + S ++ E K LE Q
Sbjct: 2859 EYLDKYCSLLISHEKLEKAKEMLETQ 2884
Score = 105 bits (262), Expect = 2e-22
Identities = 140/769 (18%), Positives = 322/769 (41%), Gaps = 121/769 (15%)
Query: 169 NKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWE 228
NK + L LQLE+ +E +K K+L+ E + + D+A+ + + + ++L +
Sbjct: 313 NKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS 372
Query: 229 NTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADR 288
Q+++ + C+LE Q+ +EKE EF++ +S R
Sbjct: 373 -----CQRQNAESARCSLE-----QKIKEKEK-----------------EFQEELSRQQR 405
Query: 289 KLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQK 348
+T Q+ + +L EL K N ++L+ L +++ ++ E +L +
Sbjct: 406 SF---QTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCR 462
Query: 349 TKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKK--- 405
+ + Q K E+ ++++ L+ +++ ++V ++ +L IK L +
Sbjct: 463 AEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNF 522
Query: 406 AQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLK------------QQEIMYS 453
A+E++ + ++ +L +++ + +N Q L E LK Q+++
Sbjct: 523 AEEMKAKNTSQETMLRDLQ------EKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKK 576
Query: 454 QDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLY 513
++ HI+Q+ ++S+ + E + ALE K E + L+E+K+ +++ +KL +
Sbjct: 577 REHHIEQLNDKLSKTEKE-SKALLSALELKKKEYEE-LKEEKTLFSCWKSENEKLLTQM- 633
Query: 514 FIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTRE 573
EK++L +KIN L + + + + + L ++ L +E++
Sbjct: 634 ---------ESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHN 684
Query: 574 MLHSKAEEV-------LSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENIST 626
+L SK+ EV + L+++ + ++ E + + + L Q+ ++ + + +S
Sbjct: 685 VLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSN 744
Query: 627 EFRERLSKIEKLKNRYEILTVVMLPPEG---------------EEEKTQAYYVIKAAQEK 671
E ++ + L YE L ++ + +++ + E+
Sbjct: 745 EIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQ 804
Query: 672 EELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEY-ELKIQLE 730
+ E + +++ K L+N + L + KQ + +E ++K ++E
Sbjct: 805 GSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIE 864
Query: 731 EQKRAVDEKYRY----KQRQIRELQEDIQSMENTL-DVIEHLANNVKE------------ 773
E ++ ++ ++I +LQED + +N + + + L N KE
Sbjct: 865 ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ 924
Query: 774 ---------------KLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKD 818
L E Q S LS E +E + ++ +LT+E LK+
Sbjct: 925 AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984
Query: 819 ETMEEQDIKLREMKQFHKVIDE---MLVDIIEENTEIRIILQTYFQQSG 864
+E+ +++ + F IDE + ++ ++ + ++IL +++G
Sbjct: 985 SLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETG 1033
Score = 102 bits (255), Expect = 1e-21
Identities = 186/904 (20%), Positives = 370/904 (40%), Gaps = 131/904 (14%)
Query: 25 KLLED---QLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKAR-ERET 80
KL ED Q + R SL+ +++E E+ S + Q L KAR +E
Sbjct: 366 KLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQEL 425
Query: 81 ESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQ--------KLDGL 132
+ ++ + Q EL ++ Q+LEN + +K E F+A+Q ++ +
Sbjct: 426 QQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQA-FQASQIKENELRRSMEEM 484
Query: 133 KCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDN---KIRALTLQLERLTLECNQKR 189
K + N + E E H +++ +++ Q N +++A E + + +K
Sbjct: 485 KKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKI 544
Query: 190 KILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKR--DGDIDNCALE 247
+N LT +L A D K + Q+L+K+ E+ IEQ+ + + ++ AL
Sbjct: 545 NQQENSLTLE-----KLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKAL- 598
Query: 248 LARIKQETREKENLVKEKIKFLESEIGNN---TEFEKRISVADRKLLKCRTAYQDHETSR 304
L+ ++ + +E E L +EK F + N T+ E K+ T + +
Sbjct: 599 LSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKS 658
Query: 305 IQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARL-------------QKTKN 351
+ + +L+ S ++ L + K + ET +L QK +
Sbjct: 659 HEYNERVRTLEMDRENLSVEIRNLHNVLDS--KSVEVETQKLAYMELQQKAEFSDQKHQK 716
Query: 352 HNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQT 411
E + K ++T + +E K L + + ++++ +++ + ++ +L K L T
Sbjct: 717 EIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVT 776
Query: 412 ETMKEKAVLS------------EIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQ----D 455
++++L+ I G + S+ + + ++ K I+ ++ +
Sbjct: 777 NEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLE 836
Query: 456 FHIQQVERRMSRLKGEINSEEKQALEAKIVE-LRKSLEEKKSTCGLLETQIKKLHNDLYF 514
F ++ ++ S L+ + EE ++ +I E L K+ + +S +I KL D
Sbjct: 837 FSLESQKQMNSDLQKQC--EELVQIKGEIEENLMKAEQMHQSFVAETSQRISKLQEDT-- 892
Query: 515 IKKAHSKNSDEKQS-LMTKINELNLFIDRSEKELDKAKGFKQ-DLMIEDNLLKLEV-KRT 571
AH E S L K EL L D+ E E + + K+ + ++ED+L +L++ T
Sbjct: 893 --SAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSET 950
Query: 572 REMLHSKAEEVLSLEKRKQQLYTAMEERTEE---IKVHKTMLASQIRYVDQERENISTEF 628
+ + ++SL KR+ +EE T+E +K L + + Q+ E+ +
Sbjct: 951 LSLEKKEMSSIISLNKRE------IEELTQENGTLKEINASLNQEKMNLIQKSESFANYI 1004
Query: 629 RERLSKIEKLKNRYEILTVVMLPPEGE-----EEKTQAYYVIKAAQEKEELQREGDCLDA 683
ER I +L ++Y+ +++L E E+ +Q Y KAAQEK L+
Sbjct: 1005 DEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKY---KAAQEKNSK------LEC 1055
Query: 684 KINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLE------------- 730
+N+ +N L+ L Q F ++E + LE
Sbjct: 1056 LLNECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMT 1115
Query: 731 -EQKRAVDEKYRYKQ----------RQIRELQEDIQSMENTLDVI-----------EHLA 768
Q + E KQ + +E+ + +Q E + V+ E +
Sbjct: 1116 DNQNNSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIR 1175
Query: 769 NNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKL-----TKEIRLLKDTKDETMEE 823
N+VKE+ SE+ +F+ + E ++ L+ Q +L KE++L + K++ +
Sbjct: 1176 NSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQ 1235
Query: 824 QDIK 827
+++
Sbjct: 1236 HELQ 1239
Score = 92.8 bits (229), Expect = 1e-18
Identities = 160/893 (17%), Positives = 358/893 (40%), Gaps = 126/893 (14%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVK------------------ 63
+EN LL+ + E L+ EL+ ++ +N + + +K
Sbjct: 486 KENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKIN 545
Query: 64 -QELSITQSLCKAR----ERETESEEHFKAIAQRELGRVKDEIQRLENEMASILE----K 114
QE S+T K E++ + + + + ++ D++ + E E ++L K
Sbjct: 546 QQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELK 605
Query: 115 KSD-----KENGIFKA-TQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDD 168
K + +E +F + + L QM +++ L++ + H ++ T Q + + +
Sbjct: 606 KKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKIN---HLETCLKTQQIKSHEYN 662
Query: 169 NKIRALTLQLERLTLECNQKRKILDNELTETIS---AQLELDKAAQDFRKIHNERQELI- 224
++R L + E L++E +LD++ E + A +EL + A+ + H + E +
Sbjct: 663 ERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMC 722
Query: 225 ---KQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEK 281
Q +E ++ + + N ++ R Q+ + +++ +K ++ + N + ++
Sbjct: 723 LKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQR 782
Query: 282 RISVADR--------------------KLLKCRTAYQDHETSRIQLKGELDSLKATV--- 318
+ D+ + +CR + L+ +DSL+ ++
Sbjct: 783 SLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQ 842
Query: 319 NRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLE 378
+ +SDL+ + + +IK +I E + + ++ Q+ + E +++ ++E + +
Sbjct: 843 KQMNSDLQKQCEELVQIKGEIEENLMKAE------QMHQSFVAETSQRISKLQEDTSAHQ 896
Query: 379 DMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQ 438
+++ E ++ + +L L+ + + E+Q E K +L + SLK L +
Sbjct: 897 NVVAETLSALENKEKELQLLNDKVETEQAEIQ-ELKKSNHLLED------SLKELQLLSE 949
Query: 439 KLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEIN---SEEKQALEAKIVELRKSLEEKK 495
L E + I+ I+++ + LK EIN ++EK L K ++E++
Sbjct: 950 TLSLEKKEMSSIISLNKREIEELTQENGTLK-EINASLNQEKMNLIQKSESFANYIDERE 1008
Query: 496 STCGLLETQIK-----------KLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSE 544
+ L Q K + N + + + ++ L +NE + +
Sbjct: 1009 KSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRK 1068
Query: 545 KELDKAK-GFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEI 603
EL++ K F ++ ++ L KL R +L LE +Q L + M +
Sbjct: 1069 NELEQLKEAFAKE--HQEFLTKLAFAEERNQ-----NLMLELETVQQALRSEMTDNQNNS 1121
Query: 604 KVHKTMLASQIRYVDQERENISTEFRERLSKIEKL----KNRYEILTVVMLP-----PEG 654
K L +I + +E+ + E + L + E+L K ++E + P E
Sbjct: 1122 KSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKER 1181
Query: 655 EEEKTQAYYVIKAAQEKEELQREG------------DCLDAKINKAEKEIYALENTLQVL 702
E E+ Q + + E +E+ + + K+ ++EKE L++ LQ +
Sbjct: 1182 ESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTI 1241
Query: 703 NSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLD 762
+ S + +I EE+ + + Q LQ +Q+ N L+
Sbjct: 1242 RGDLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLN 1301
Query: 763 VIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKD 815
+E + ++ +EK +L+ E ++ ++ KL E+++L D
Sbjct: 1302 ELEKICEILQ---AEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILND 1351
Score = 80.9 bits (198), Expect = 5e-15
Identities = 160/815 (19%), Positives = 332/815 (40%), Gaps = 120/815 (14%)
Query: 91 QRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEES 150
Q ++ ++ ++ NE +L D++ + ++ L +++ + L +E
Sbjct: 1766 QEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEA- 1824
Query: 151 AHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLEL--DK 208
+ L+K + + L+ +LE + C+ + + E +E +++ LE+ DK
Sbjct: 1825 ------CIELEKIVGELKKENSDLSEKLEYFS--CDHQELLQRVETSEGLNSDLEMHADK 1876
Query: 209 AAQD-----FRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVK 263
++++ K+++ +E EN + +++ I++ AL L E + E L
Sbjct: 1877 SSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYL-EADLEVVQTEKLCL 1935
Query: 264 EKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSS 323
EK + E ++++ V + L T+ R QL+GELD++
Sbjct: 1936 EK----------DNENKQKVIVCLEEELSVVTS------ERNQLRGELDTMSKKTTALDQ 1979
Query: 324 DLEALRKNISKIKKDIHEETARLQ----KTKNHNEIIQTKLKEITEKTMSVEEKATNLED 379
E +++ +++ E +Q + K E++QT +++E + + T+L++
Sbjct: 1980 LSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSSDVSE----LLKDKTHLQE 2035
Query: 380 MLKEEEKDVKEVDV----------QLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSS 429
L+ EKD + + + QLN K +L K+++ LQ A LSE S
Sbjct: 2036 KLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESESLQ-------ARLSE-----SD 2083
Query: 430 LKHLNHQLQKLDFETLKQQEI---MYSQDFHIQQVERRMSRLKGEINSEEKQALEA--KI 484
+ LN + L+ +++ E + S + Q+ R + +L+ I ++EK+ L K+
Sbjct: 2084 YEKLNVS-KALEAALVEKGEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKL 2142
Query: 485 VELRKSLEEKKSTCGLLET--QIKKLHNDLYFIKKAHSK-------NSDEKQSLMTKINE 535
E + + K LE Q+ + + +L + +SK E+ + K+ E
Sbjct: 2143 KERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVFE 2202
Query: 536 LNLFIDRSEKE-LDKAKGFKQDLMIE-DNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLY 593
L+L RSEKE L K KQ + E D LL + +L K + + +++ +
Sbjct: 2203 LDLVTLRSEKENLTKQIQEKQGQLSELDKLLS----SFKSLLEEKEQAEIQIKEESKTAV 2258
Query: 594 TAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRER---LSKIEKLKNRYEILTVVML 650
++ + +E+ L + +++ E + IEKL+ R E
Sbjct: 2259 EMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEA------ 2312
Query: 651 PPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYK 710
+EK Q + Q+ +E + D L ++ E+E L N +
Sbjct: 2313 -----DEKKQ----LCVLQQLKESEHHADLLKGRVENLERE----------LEIARTNQE 2353
Query: 711 QSFKKVTPSSDEYE-LKIQLEEQKRA-------VDEKYRYKQRQIRELQEDIQSMENTLD 762
+ + S E E LK ++E ++ V K+ ELQ++ + +
Sbjct: 2354 HAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEI 2413
Query: 763 VIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETME 822
+ N ++EK EK + S E + +L+ + ++ A L + K +
Sbjct: 2414 INSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSS 2473
Query: 823 EQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQ 857
+ + E Q + +DE + I + + ++Q
Sbjct: 2474 QVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQ 2508
Score = 78.2 bits (191), Expect = 3e-14
Identities = 169/884 (19%), Positives = 348/884 (39%), Gaps = 141/884 (15%)
Query: 136 MNWDQQALEAW--------LEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQ 187
M+W ALE W L++ + L+K QQ ++ +L L++ Q
Sbjct: 1 MSW---ALEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQK------Q 51
Query: 188 KRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALE 247
K+K+ +NE TE + + E + + + +Q++ + + Q+ ++G +++ +
Sbjct: 52 KQKV-ENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQ 110
Query: 248 LARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHET----S 303
+ +++QE +K +SE+ + ++ AD L C T + T S
Sbjct: 111 IEKLEQE-----------LKRCKSELERS---QQAAQSADVSLNPCNTPQKIFTTPLTPS 156
Query: 304 RIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEI 363
+ + + LK N+ + + L + ++ +T Q T NH +I + +
Sbjct: 157 QYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLP-QATMNHRDIARHQASSS 215
Query: 364 T-----EKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKA 418
EKT S + + ++ + ++ + L ++ + +
Sbjct: 216 VFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSS 275
Query: 419 VLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEK- 477
++ ++ + L +++ +L+ ++ M Q Q+++ ++ + K E+ +EK
Sbjct: 276 SPHLLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKV 335
Query: 478 -QALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKK-AHSKNSDEKQSLMTKINE 535
++V ++ + LE ++KKL DL ++ A S +Q + K E
Sbjct: 336 LNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKE 395
Query: 536 LNLFIDRSEK--------------------------------ELDKAKGFKQDLMIEDNL 563
+ R ++ ELDK KQ L E+NL
Sbjct: 396 FQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKLTSVKQQL--ENNL 453
Query: 564 LKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEE---IKVHKTMLASQIRYVDQE 620
+ + K R +A ++ ++ +L +MEE +E +K H A ++ +++ E
Sbjct: 454 EEFKQKLCRAEQAFQASQI-----KENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAE 508
Query: 621 RENISTEFRERLSKIEKLKNR---YEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQRE 677
+NI + + E++K + E + + ++E + +K A +L+++
Sbjct: 509 LKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLA--VADLEKQ 566
Query: 678 GDC--------------LDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTP-SSDE 722
DC L+ K++K EKE AL + L++ K+ + S+
Sbjct: 567 RDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSEN 626
Query: 723 YELKIQLEEQKRAVDEKYRY-----KQRQIR--ELQEDIQSM----ENTLDVIEHLANNV 771
+L Q+E +K + K + K +QI+ E E ++++ EN I +L N +
Sbjct: 627 EKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVL 686
Query: 772 KEK-------------LSEKQAYSFQL-SKETEEQKPKLERVTKQCAKLTKEIRLLKD-- 815
K L +K +S Q KE E K ++T Q L +++LL +
Sbjct: 687 DSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEI 746
Query: 816 -TKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQSGLELPTASTKG 874
KD ++ + ++ K D LV N + + L + QQ + A+ G
Sbjct: 747 MDKDRCYQDLHAEYESLRDLLKSKDASLV----TNEDHQRSLLAFDQQPAMHHSFANIIG 802
Query: 875 SRQSSRSP-SHTSLSARSSRSTSTSTSQSSIKVLELKFPASSSL 917
+ S S S L A S S + Q+ + LE + +
Sbjct: 803 EQGSMPSERSECRLEADQSPKNS-AILQNRVDSLEFSLESQKQM 845
Score = 77.4 bits (189), Expect = 6e-14
Identities = 183/871 (21%), Positives = 356/871 (40%), Gaps = 135/871 (15%)
Query: 25 KLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEE 84
+L + + +LK+E+ E E+ + M S +N++ +++ ++ K ++ +S E
Sbjct: 603 ELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQ--IKSHE 660
Query: 85 HFKAIAQRELGR--VKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMN--WDQ 140
+ + + E+ R + EI+ L N +L+ KS + TQKL ++ Q +
Sbjct: 661 YNERVRTLEMDRENLSVEIRNLHN----VLDSKS-----VEVETQKLAYMELQQKAEFSD 711
Query: 141 QALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQL---ERLTLECNQKRKILDNELT 197
Q + +E K S L + ++K++ L+ ++ +R + + + + L +L
Sbjct: 712 QKHQKEIENMCLKTSQ---LTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESL-RDLL 767
Query: 198 ETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETRE 257
++ A L ++ Q +++ + + N I + + C LE + + +
Sbjct: 768 KSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI 827
Query: 258 KENLVKEKIKFLESEIGNNTEFEKRISVA-------DRKLLKCRTAYQDH--ETSR--IQ 306
+N V LES+ N++ +K+ + L+K +Q ETS+ +
Sbjct: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISK 887
Query: 307 LKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEIT-- 364
L+ + + + V T S LE K + + + E A +Q+ K N +++ LKE+
Sbjct: 888 LQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLL 947
Query: 365 EKTMSVEEK------ATNLEDM--LKEEEKDVKEVDVQLNLIKGVLFKKAQ--------- 407
+T+S+E+K + N ++ L +E +KE++ LN K L +K++
Sbjct: 948 SETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDER 1007
Query: 408 -----ELQTETMKEKAVLSE-IEGTRSSLKHLNHQLQ----------------------- 438
EL + +EK +L + E T ++ + L+ + +
Sbjct: 1008 EKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENR 1067
Query: 439 KLDFETLKQQEIMYSQDF--HIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKS 496
K + E LK+ Q+F + E R L E+ + + QAL + E+ + KS
Sbjct: 1068 KNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQ-QALRS---EMTDNQNNSKS 1123
Query: 497 TCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLM----TKINELNLF---IDRSEKELDK 549
G L+ +I L + ++K + E + LM TK NL I S KE +
Sbjct: 1124 EAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERES 1183
Query: 550 AKG---FKQDLMIEDNLLKLE-----VKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTE 601
+ FK + +E + L+ + + ML +K ++ EK K+ L ++
Sbjct: 1184 ERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRG 1243
Query: 602 EIKVH--KTMLASQIR-----YVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEG 654
+++ + M + +I +D E + IS S+ + + + T + E
Sbjct: 1244 DLETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNEL 1303
Query: 655 EE--EKTQAYYVIKAAQEKEELQRE-----GDCLDAKINKAEKEIYALENTLQVLNSCNN 707
E+ E QA EK EL E +C+ A AE E+ L N +++LN +
Sbjct: 1304 EKICEILQA--------EKYELVTELNDSRSECITATRKMAE-EVGKLLNEVKILNDDSG 1354
Query: 708 NYKQSFKKVTPSSDEYELKIQLEEQKRA-VDEKYRYK---------QRQIRELQEDIQSM 757
+ P + E + A +DE Y+ Q ELQE S+
Sbjct: 1355 LLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSL 1414
Query: 758 ENTLDVIEHLANNVKEKLSEKQAYSFQLSKE 788
++ ++ + K+SE Q Y L E
Sbjct: 1415 QSEHKILHDQHCQMSSKMSELQTYVDSLKAE 1445
Score = 68.6 bits (166), Expect = 3e-11
Identities = 145/765 (18%), Positives = 303/765 (39%), Gaps = 87/765 (11%)
Query: 23 ENKLLEDQL--SKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQ----SLCKAR 76
ENK E QL K++ E+A +Q EL++ + + + + LS+ + S+
Sbjct: 907 ENKEKELQLLNDKVETEQAEIQ-ELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLN 965
Query: 77 ERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQM 136
+RE E +E G +K+ L E ++++K N I + + + L Q
Sbjct: 966 KREIEE-------LTQENGTLKEINASLNQEKMNLIQKSESFANYIDEREKSISELSDQY 1018
Query: 137 NWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRAL----TLQLERLTLECNQKRKIL 192
++ L EE+ + D K AQ+ ++K+ L T E E Q ++
Sbjct: 1019 KQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAF 1078
Query: 193 DNELTETI-----------SAQLELDKAAQDFRKIHNERQELIKQWENTIEQ-------- 233
E E + + LEL+ Q R + Q K ++Q
Sbjct: 1079 AKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEE 1138
Query: 234 ---MQKRDGDIDNCALELARIKQETREKENL----VKEKIKFLESEIGNNTEFEKRISVA 286
MQK D+ +L ++ + E +NL ++ +K ESE N F+ ++ +
Sbjct: 1139 QNKMQKEVNDLLQENEQLMKVMKTKHECQNLESEPIRNSVKERESE-RNQCNFKPQMDLE 1197
Query: 287 DRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARL 346
+++ + + +QL+ L + + + + + E L+ + I+ D+ ET+ L
Sbjct: 1198 VKEI-----SLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDL--ETSNL 1250
Query: 347 QKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKA 406
Q ++ ++ + + + EEK + L + D + L L +
Sbjct: 1251 QDMQSQ------EISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELE 1304
Query: 407 QELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMS 466
+ + ++ +++E+ +RS ++ + + L + +I+ + D + E
Sbjct: 1305 KICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKIL-NDDSGLLHGELVED 1363
Query: 467 RLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQI--KKLHNDLYFIKKAHSKNSD 524
GE + + + L +S + T E Q+ +L ++ H D
Sbjct: 1364 IPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQSEHKILHD 1423
Query: 525 EKQSLMTKINELNLFIDRSEKE----LDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAE 580
+ + +K++EL ++D + E + F+ DL +++ L LE + S
Sbjct: 1424 QHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL-VKEMQLGLEEGLVPSLSSSCVP 1482
Query: 581 EVLSLEK-RKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLK 639
+ SL Y A+ E+T ++ ++L++ V + ++ F L + E L
Sbjct: 1483 DSSSLSSLGDSSFYRALLEQTGDM----SLLSNLEGAVSANQCSVDEVFCSSLQE-ENLT 1537
Query: 640 NRYEILTVVMLPPEGEEEKTQAYYVIKAAQEK--EELQREGDCLDAKINKAEKEIYALEN 697
+ P +G EE V + + EK E+++ +G + +I + E+ + +
Sbjct: 1538 RK----ETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNKEIQELEQLLSSERQ 1593
Query: 698 TLQVLN----SCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDE 738
L L S N ++Q VT E++ +L +K+ ++
Sbjct: 1594 ELDCLRKQYLSENEQWQQKLTSVT-----LEMESKLAAEKKQTEQ 1633
Score = 50.8 bits (120), Expect = 6e-06
Identities = 73/366 (19%), Positives = 151/366 (41%), Gaps = 43/366 (11%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSIT--------QSLCKARER 78
LE ++ L+ + ASLQD L + S +KN++ EL +T + + K +
Sbjct: 2565 LEQKIQVLQSKNASLQDTLEVLQ-------SSYKNLENELELTKMDKMSFVEKVNKMTAK 2617
Query: 79 ETESEEHFKAIAQREL---GRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQ 135
ETE + +AQ+ + E RL E+ +LE+ ++ + + T + LK
Sbjct: 2618 ETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKS 2677
Query: 136 ---MNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQL-ERLTLECNQKRKI 191
M+ DQ E + E + Q + + K +AL L ++ +E R+
Sbjct: 2678 LDCMHKDQVEKEGKVRE------EIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREK 2731
Query: 192 LDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARI 251
L ++ S +LE+D +++N +K +E+++K D L +
Sbjct: 2732 LTSKEECLSSQKLEIDLLKSSKEELNNS----LKATTQILEELKKTKMD------NLKYV 2781
Query: 252 KQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGEL 311
Q +E E + K+K L I + + E+ + ++L + + A + +T + + ++
Sbjct: 2782 NQLKKENER-AQGKMKLL---IKSCKQLEEEKEILQKELSQLQAAQEKQKTGTV-MDTKV 2836
Query: 312 DSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVE 371
D L + LE K + +K + E+++T++ + + +
Sbjct: 2837 DELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQD 2896
Query: 372 EKATNL 377
+ + L
Sbjct: 2897 SRGSPL 2902
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 136 bits (342), Expect = 1e-31
Identities = 178/871 (20%), Positives = 372/871 (42%), Gaps = 124/871 (14%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
L+ Q+ +LK + A ++EL+ R + T H N + + Q+ + + ESE+
Sbjct: 1074 LQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKAS 1133
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAW 146
+ A+++ + +E++ L+ E+ L+ + ++ K Q++ LK + + + EA
Sbjct: 1134 RNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQ 1193
Query: 147 LEESAHKDSDAL---------------TLQKYAQ--QDDNKIRALTLQ-LERLTLECNQK 188
+++ + + AL L+K Q + DNK A ++ L+++ E K
Sbjct: 1194 IQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHK 1253
Query: 189 RKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALEL 248
RK LD ++ E + E D+ + + ++ Q + +E+ +K+ A L
Sbjct: 1254 RKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASL 1313
Query: 249 AR--------IKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDH 300
+++ETR+K NL +I+ LE E + E ++ A + L
Sbjct: 1314 ESQLQDTQELLQEETRQKLNL-SSRIRQLEEEKNSLQEQQEEEEEARKNL---------- 1362
Query: 301 ETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIH------EETA----RLQKTK 350
E + L+ +L K V+ +E+L + K+ KD EE A +L+KTK
Sbjct: 1363 EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTK 1422
Query: 351 NHNEIIQTKLKEITEKTMSVEEKATNLEDMLKE----------------EEKDVKEVDVQ 394
N +Q +L ++T + A+NLE K+ EE+D E + +
Sbjct: 1423 NR---LQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAR 1479
Query: 395 LNLIKGVLFKKAQELQTETMKE-----KAVLSEIEGTRSS-------------------- 429
K + +A E E +E K + +++E SS
Sbjct: 1480 EKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQ 1539
Query: 430 -LKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSR---LKGEINSEEKQALEAKIV 485
++ + QL++L+ E ++ + ++Q ++ + R + E N E+K+ L ++
Sbjct: 1540 QVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVR 1599
Query: 486 ELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEK 545
EL LE+++ L KK+ DL ++ + + ++ ++ +L + ++
Sbjct: 1600 ELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQR 1659
Query: 546 ELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEI-- 603
EL++A+ + ++ + + ++K + EE+ S E+ ++ +E +EI
Sbjct: 1660 ELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITN 1719
Query: 604 -KVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYE--ILTVVMLPPEGEEEKTQ 660
K+ L + R ++ + E E S +E L +R+ L V L E E++
Sbjct: 1720 SASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSA 1779
Query: 661 AYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSS 720
A K+ +++L+R+ L AK+ + E + + +K + +
Sbjct: 1780 AQ---KSDNARQQLERQNKELKAKLQELE-------------GAVKSKFKATISALEAKI 1823
Query: 721 DEYELKIQLEEQKRAVDEK-YRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQ 779
+ E +++ E ++RA K R +++++E+ ++ D H A+ KE++ +
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQVE------DERRH-ADQYKEQMEKAN 1876
Query: 780 AYSFQLSKETEEQKPKLERVTKQCAKLTKEI 810
A QL ++ EE + + R KL +E+
Sbjct: 1877 ARMKQLKRQLEEAEEEATRANASRRKLQREL 1907
Score = 130 bits (327), Expect = 6e-30
Identities = 178/848 (20%), Positives = 362/848 (42%), Gaps = 119/848 (14%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETE 81
EE LLEDQ SK E+ ++D + E ++ KN+ + + + + E +
Sbjct: 985 EEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLK 1044
Query: 82 SEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQ 141
EE + Q LE + + +D ++ I + ++D LK Q+ ++
Sbjct: 1045 KEEKTR--------------QELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEE 1090
Query: 142 ALEAWL----EESAHKDSDALTLQKY------AQQDDNKIRALTLQLERLTLECNQKRKI 191
L+ L +E+ HK++ +++ Q+D +A + E+ + +++ +
Sbjct: 1091 ELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEA 1150
Query: 192 LDNELTETI---SAQLEL-DKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALE 247
L EL +T+ +AQ EL K Q+ ++ +E K E I+ M++R ALE
Sbjct: 1151 LKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHA----TALE 1206
Query: 248 --LARIKQETREKENLVKEK-------------IKFLESEIGNNTEFEKRISVADRKLLK 292
+++Q R K NL K K +K L+ E E + D ++ +
Sbjct: 1207 ELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQV---KAESEHKRKKLDAQVQE 1263
Query: 293 CRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNH 352
+ + R++L + L+ ++ S+ LE K K KD ++LQ T+
Sbjct: 1264 LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ-- 1321
Query: 353 NEIIQTKLKE---ITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQEL 409
E++Q + ++ ++ + +EE+ +L++ +EEE+ K ++ K+ L
Sbjct: 1322 -ELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLE-----------KQVLAL 1369
Query: 410 QTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLK 469
Q++ K + + GT SL+ +L K D E L Q+ + + ++E+ +RL+
Sbjct: 1370 QSQLADTKKKVDDDLGTIESLEEAKKKLLK-DAEALSQR--LEEKALAYDKLEKTKNRLQ 1426
Query: 470 GEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSL 529
E++ +L L+ ++ LE + KK L K ++ ++E+
Sbjct: 1427 QELD------------DLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRA 1474
Query: 530 MTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRK 589
+ E + L++A K++ ++ L+ +++ + V LEK K
Sbjct: 1475 EAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSK 1534
Query: 590 QQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEK----------LK 639
+ A+E++ EE++ L +++ + + + + ++ E+ K
Sbjct: 1535 R----ALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK 1590
Query: 640 NRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTL 699
R I V L E E+E+ Q + A+++K E+ + L+A+I A K + L
Sbjct: 1591 KRLLIKQVRELEAELEDERKQRALAV-ASKKKMEIDLKD--LEAQIEAANKARDEVIKQL 1647
Query: 700 QVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMEN 759
+ L + +Y++ ++ S DE + Q + ++K + + +I +LQE++ S E
Sbjct: 1648 RKLQAQMKDYQRELEEARASRDE------IFAQSKESEKKLKSLEAEILQLQEELASSER 1701
Query: 760 T-----------LDVIEHLANNVKEKLSEK---QAYSFQLSKETEEQKPKLERVTKQCAK 805
D I + A+ L EK +A QL +E EE++ +E + + K
Sbjct: 1702 ARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRK 1761
Query: 806 LTKEIRLL 813
T ++ L
Sbjct: 1762 TTLQVDTL 1769
Score = 115 bits (289), Expect = 1e-25
Identities = 154/775 (19%), Positives = 342/775 (44%), Gaps = 61/775 (7%)
Query: 93 ELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAH 152
++ R ++E+Q + E+ + EK++ E + + +K L + N + L+A E A
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 153 KDSDALTLQKYAQQDDNKIRALTLQL----ERLTLECNQKRKI------LDNELTETISA 202
+ L Q+ + + L ++ ER + N+K+K+ L+ +L E A
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 203 --QLELDKAAQDFRKIHNERQELIKQWENT--IEQMQKRDGDIDNCALELARIKQETREK 258
+L+L+K + + E + L+ + +N+ I++ + + I C+ +LA +E +
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLA---EEEEKA 1022
Query: 259 ENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATV 318
+NL K + K E IS + +L K Q+ E ++ +L GE L+ +
Sbjct: 1023 KNLAKIRNK-----------QEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQI 1071
Query: 319 NRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLE 378
+ ++ L+ ++K ++++ AR H ++E+ + ++E + +
Sbjct: 1072 AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEK 1131
Query: 379 DMLKEEEKDVKEVDVQLNLIK----GVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLN 434
+ EK +++ +L +K L A + + T +E+ V + K+
Sbjct: 1132 ASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHE 1191
Query: 435 HQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQ-ALEAKIVELRKSLEE 493
Q+Q + E + Q ++ + + + K + ++ K+ A E K+++ K+ E
Sbjct: 1192 AQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESE 1251
Query: 494 KKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGF 553
K L+ Q+++LH + + + +++ L +++ ++ ++ +EK KG
Sbjct: 1252 HKRK--KLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEK-----KGI 1304
Query: 554 KQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQL---YTAMEERTEEIKVHKTML 610
K + L+ +++ T+E+L + + L+L R +QL +++E+ EE + + L
Sbjct: 1305 K--FAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNL 1362
Query: 611 ASQIRYVDQERENISTEFRERLSKIEKLKN-RYEILTVVMLPPEGEEEKTQAYYVIKAAQ 669
Q+ + + + + + L IE L+ + ++L + EEK AY K +
Sbjct: 1363 EKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY--DKLEK 1420
Query: 670 EKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQL 729
K LQ+E D L ++ + LE + + K + D E + +
Sbjct: 1421 TKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEARE 1480
Query: 730 EEQK-----RAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQ 784
+E K RA++E K+ R+ ++ ME+ + + + NV E K+A
Sbjct: 1481 KETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRA---- 1536
Query: 785 LSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETME---EQDIKLREMKQFHK 836
L ++ EE + +LE + + + T++ +L + + M+ E+D++ R+ + K
Sbjct: 1537 LEQQVEEMRTQLEELEDE-LQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK 1590
Score = 102 bits (253), Expect = 2e-21
Identities = 141/709 (19%), Positives = 305/709 (43%), Gaps = 98/709 (13%)
Query: 246 LELARIKQETREK-ENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSR 304
L++ R ++E + K E L+K K K + E G E E++ ++LL+ + + +
Sbjct: 845 LQVTRQEEELQAKDEELLKVKEKQTKVE-GELEEMERK----HQQLLEEKNILAEQLQAE 899
Query: 305 IQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEIT 364
+L E + ++A + +LE + +H+ +R+++ + N+I+Q + K++
Sbjct: 900 TELFAEAEEMRARLAAKKQELEEI----------LHDLESRVEEEEERNQILQNEKKKM- 948
Query: 365 EKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIE 424
+ +LE+ L EEE +++ ++ + + K +E+ + + E +
Sbjct: 949 ------QAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKK 1002
Query: 425 GTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEK--QALEA 482
+ + QL + + + +I Q+ I +E R+ + + EK + L+
Sbjct: 1003 LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062
Query: 483 KIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEK----------QSLMTK 532
+ +L+ + E ++ L+ Q+ K +L + A ++ DE + L +
Sbjct: 1063 ETTDLQDQIAELQAQIDELKLQLAKKEEEL---QGALARGDDETLHKNNALKVVRELQAQ 1119
Query: 533 INELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRT-------REMLHSKAEEVLSL 585
I EL + + +KA+ K+DL E LK E++ T +E+ + +EV L
Sbjct: 1120 IAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAEL 1179
Query: 586 EKR---------------KQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRE 630
+K +Q+ TA+EE +E+++ K A+ +++ ++ + T+ +E
Sbjct: 1180 KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKAN----LEKNKQGLETDNKE 1235
Query: 631 RLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKI-NKAE 689
+++ +L V E + +K A QE EGD L ++ KA
Sbjct: 1236 LACEVK-------VLQQVKAESEHKRKKLDAQ-----VQELHAKVSEGDRLRVELAEKAS 1283
Query: 690 KEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYK---QRQ 746
K L+N +L K + + D L+ QL++ + + E+ R K +
Sbjct: 1284 KLQNELDNVSTLLEEAEK------KGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSR 1337
Query: 747 IRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKL 806
IR+L+E+ S++ + E N+++++ Q+ K+ ++ +E + + KL
Sbjct: 1338 IRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL 1397
Query: 807 TKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDI-----IEENTEIRIILQTYFQ 861
K+ L +E D + + + +D++ VD+ + N E + Q F
Sbjct: 1398 LKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKK---QKKFD 1454
Query: 862 QSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTSQSSIKVLELK 910
Q E + S + + + R+ + AR + + S +++ + LE K
Sbjct: 1455 QLLAEEKSISARYAEERDRAEA----EAREKETKALSLARALEEALEAK 1499
Score = 99.8 bits (247), Expect = 1e-20
Identities = 150/803 (18%), Positives = 338/803 (42%), Gaps = 92/803 (11%)
Query: 59 FKNVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDK 118
F VK L +T+ +E E ++++ + + +V+ E++ +E + +LE+K+
Sbjct: 838 FTKVKPLLQVTR-----QEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNIL 892
Query: 119 ENGIFKATQ---KLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALT 175
+ T+ + + ++ ++ +Q LE L + L+ ++++ + + L
Sbjct: 893 AEQLQAETELFAEAEEMRARLAAKKQELEEILHD----------LESRVEEEEERNQILQ 942
Query: 176 LQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQ 235
+ +++ + LD E QLE A +K+ E L Q I++ +
Sbjct: 943 NEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKK 1002
Query: 236 KRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRT 295
+ I C+ +LA +E + +NL K + K E IS + +L K
Sbjct: 1003 LMEDRIAECSSQLA---EEEEKAKNLAKIRNKQ-----------EVMISDLEERLKKEEK 1048
Query: 296 AYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEI 355
Q+ E ++ +L GE L+ + + ++ L+ ++K ++++ AR H
Sbjct: 1049 TRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNN 1108
Query: 356 IQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMK 415
++E+ + ++E + + + EK +++ +L +K L +T+
Sbjct: 1109 ALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTEL--------EDTLD 1160
Query: 416 EKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSE 475
A E+ R+ + +L+K E K E IQ + +R + E++ +
Sbjct: 1161 TTAAQQEL---RTKREQEVAELKKALEEETKNHEAQ------IQDMRQRHATALEELSEQ 1211
Query: 476 EKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINE 535
+QA K +LE+ K LET K+L ++ +++ +++ +++ L ++ E
Sbjct: 1212 LEQAKRFKA-----NLEKNKQG---LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE 1263
Query: 536 LNLFI---DRSEKEL-DKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQ 591
L+ + DR EL +KA + +L LL+ K+ + A++ SLE + Q
Sbjct: 1264 LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF----AKDAASLESQLQD 1319
Query: 592 LYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLP 651
++E T + K L+S+IR +++E+ ++ + E + L+ ++L +
Sbjct: 1320 TQELLQEETRQ----KLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK--QVLALQSQL 1373
Query: 652 PEGEEEKTQAYYVIKAAQE-KEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYK 710
+ +++ I++ +E K++L ++ + L ++ + LE T N +
Sbjct: 1374 ADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKT-------KNRLQ 1426
Query: 711 QSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANN 770
Q +T D +R V KQ++ +L + +S+ +
Sbjct: 1427 QELDDLTVDLDH----------QRQVASNLEKKQKKFDQLLAEEKSISARY---AEERDR 1473
Query: 771 VKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLRE 830
+ + EK+ + L++ EE E +Q +L ++ L +KD+ + +
Sbjct: 1474 AEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKS 1533
Query: 831 MKQFHKVIDEMLVDIIEENTEIR 853
+ + ++EM + E E++
Sbjct: 1534 KRALEQQVEEMRTQLEELEDELQ 1556
Score = 92.8 bits (229), Expect = 1e-18
Identities = 125/586 (21%), Positives = 247/586 (42%), Gaps = 103/586 (17%)
Query: 323 SDLEALRKNISKIKKDIHEETAR--------LQKTKNHNEIIQTKLKEITEKTMSVEEKA 374
S L+ L++N + K H + R LQ T+ E+ Q K +E+ + V+EK
Sbjct: 814 SALKVLQRNCAAYLKLRHWQWWRVFTKVKPLLQVTRQEEEL-QAKDEEL----LKVKEKQ 868
Query: 375 TNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLN 434
T +E L+E E+ +++ + N++ A++LQ ET + +E E R+ L
Sbjct: 869 TKVEGELEEMERKHQQLLEEKNIL-------AEQLQAET----ELFAEAEEMRARLAAKK 917
Query: 435 HQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEK 494
+L+ EI++ + +++ E R +I EK+ ++A I +L + L+E+
Sbjct: 918 QELE----------EILHDLESRVEEEEER-----NQILQNEKKKMQAHIQDLEEQLDEE 962
Query: 495 KSTCGLL-------ETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSE--- 544
+ L E +IKK+ ++ ++ +SK EK+ + +I E + + E
Sbjct: 963 EGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKA 1022
Query: 545 KELDKAKGFKQDLMIED--NLLKLEVKRTREMLHSKA----------EEVLSLEKRKQQL 592
K L K + KQ++MI D LK E K +E+ +K +++ L+ + +L
Sbjct: 1023 KNLAKIRN-KQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDEL 1081
Query: 593 YTAMEERTEEIK----------VHKTMLASQIRYVDQERENISTEF-------------- 628
+ ++ EE++ +HK +R + + + +F
Sbjct: 1082 KLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQK 1141
Query: 629 RERLSKIEKLKNRYE-ILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINK 687
R+ ++E LK E L E ++ Q +K A E+E E D +
Sbjct: 1142 RDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRH 1201
Query: 688 AEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYK-QRQ 746
A + L L+ N +++ + + + E ++++ +Q +A E R K Q
Sbjct: 1202 ATA-LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQ 1260
Query: 747 IRELQ--------------EDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQ 792
++EL E ++N LD + L ++K + + L + ++
Sbjct: 1261 VQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDT 1320
Query: 793 KPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVI 838
+ L+ T+Q L+ IR L++ K+ E+Q+ + K K +
Sbjct: 1321 QELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366
Score = 83.2 bits (204), Expect = 1e-15
Identities = 98/557 (17%), Positives = 224/557 (40%), Gaps = 62/557 (11%)
Query: 12 EDGFAIPVANEENKLLEDQLSKLK--------------DERASLQDELREYEERINSMTS 57
+D A+ EE L D+L K K D + + L + +++ + + +
Sbjct: 1399 KDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLA 1458
Query: 58 HFKNVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSD 117
K++ + + +A RE E++ A A E K+E +R ++ + +E
Sbjct: 1459 EEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMS 1518
Query: 118 KENGIFKATQKLDGLKCQMNWDQQALEAWLEE-------------------SAHKDSDAL 158
++ + K +L+ K + + + LEE A K
Sbjct: 1519 SKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFER 1578
Query: 159 TLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHN 218
LQ +Q++ K R L Q+ L E +RK + +++L +
Sbjct: 1579 DLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANK 1638
Query: 219 ERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTE 278
R E+IKQ QM+ +++ I +++E E +K+K LE+EI +
Sbjct: 1639 ARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESE----KKLKSLEAEI---LQ 1691
Query: 279 FEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKD 338
++ ++ ++R A + E R +L E+ + + + + L I++++++
Sbjct: 1692 LQEELASSER-------ARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEE 1744
Query: 339 IHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLI 398
+ EE + ++ + ++ + + + A ++ ++ E+ KE+ +L +
Sbjct: 1745 LEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQEL 1804
Query: 399 KGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHI 458
+G + K KA +S +E + + L QL++ E +++ + +
Sbjct: 1805 EGAVKSKF----------KATISALE---AKIGQLEEQLEQEAKERAAANKLVRRTEKKL 1851
Query: 459 QQVERRMS--RLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIK 516
+++ ++ R + E+ + A++ +L++ LEE + +KL +L
Sbjct: 1852 KEIFMQVEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDAT 1911
Query: 517 KAHSKNSDEKQSLMTKI 533
+A+ S E +L ++
Sbjct: 1912 EANEGLSREVSTLKNRL 1928
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 129 bits (325), Expect = 1e-29
Identities = 203/990 (20%), Positives = 414/990 (41%), Gaps = 124/990 (12%)
Query: 12 EDGFAIPVANEENKLLEDQLSKLKDERASLQDE---LREYEERINSMTSHFKN------V 62
E+ F V NE+ K LED L +L+ + + L+DE + + ++ H K+
Sbjct: 322 ENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHERE 381
Query: 63 KQELSITQSLCKARERETESEEHFKAIA-------------QRELGRVKDEIQRLENEMA 109
E I + L E+ E+ +A RE+ +K++ Q+ +E+
Sbjct: 382 DLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELN 441
Query: 110 SILEKKSDKENGIFKATQKLDGLKCQM-NWDQQALEAWLEESAHKDSDALTLQKYAQQDD 168
S+KE ++ GLK Q N Q+ EA L + ++ + + +
Sbjct: 442 ETFLSDSEKEK--LTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAG 499
Query: 169 NKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWE 228
+ ++ + ++ ++ L TE A LE Q + +QEL+ + E
Sbjct: 500 KISQEFESMKQQQASDVHELQQKLRTAFTEK-DALLETVNRLQGENEKLLSQQELVPELE 558
Query: 229 NTIEQMQKRDG-------DIDNCALEL-ARIKQETREKENLVKEKIKFLESEIGN---NT 277
NTI+ +Q+++G D EL +I T EK++ + K+K E+ N
Sbjct: 559 NTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFI-NKLKNSHEEMDNFHKKC 617
Query: 278 EFEKRISVADRKLLKCRTAYQDHETSRI-QLKGELDSLKATVNRTSSDLEAL-------- 328
E E+R+ + K ++ Y ++ +L G L+ ++ LE L
Sbjct: 618 EREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLS 677
Query: 329 --RKNISKIKKDIHEETARLQKTK-------------NHNEIIQTKLKEITEKTMSVEEK 373
++ +S K ++EE +L K + I++ + ++ +K + E+
Sbjct: 678 EDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEE 737
Query: 374 ATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHL 433
NL +L+ E+ V QL G L + E+ +E +EK V++ ++ SL +
Sbjct: 738 QDNLNKLLENEQVQKLFVKTQL---YGFLKEMGSEV-SEDSEEKDVVNVLQAVGESLAKI 793
Query: 434 NHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGE--INSEEKQAL----EAKIVEL 487
N + L F+ +D + ++E+ + L+ E + EE ++L E + V L
Sbjct: 794 NEEKCNLAFQ----------RDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLL 843
Query: 488 RKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKEL 547
RK LEE ++++ + L +DL +K A+ K E Q+L+ ++ E++ +SE
Sbjct: 844 RKELEE-------IQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHN 896
Query: 548 DKAKGF---------------KQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQL 592
+K K F +D E LLK + ++ + + V LE++ + L
Sbjct: 897 EKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENL 956
Query: 593 YTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVM--L 650
+E+ E+I K + + +D R+ T E +E L++ + L+ M L
Sbjct: 957 EKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEE----LESLRSEKDQLSASMRDL 1012
Query: 651 PPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYK 710
E K K +++ + + + + +I +++ + +NS N +
Sbjct: 1013 IQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLL 1072
Query: 711 QSFKKVTPSSDEYELKI-QLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLAN 769
+ + ++ E++I +++ K VD++ ++ Q + ++ + N L+ ++
Sbjct: 1073 ARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQ 1132
Query: 770 NVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETME--EQDIK 827
K++L +K +L K+ +Q + +L KE+ K+ +E EQ+IK
Sbjct: 1133 KEKKQL-QKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIK 1191
Query: 828 LREMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQ-SGLELPTASTKGSRQSSRSPSHTS 886
+++ KQ + EE T ++ +Q Y ++ + ++ TK S+
Sbjct: 1192 IQKQKQ---------ETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDH 1242
Query: 887 LSARSSRSTSTSTSQSSIKVLELKFPASSS 916
L ++S SQ ++V +++ +S
Sbjct: 1243 LILQASLKGELEASQQQVEVYKIQLAEITS 1272
Score = 103 bits (258), Expect = 6e-22
Identities = 190/952 (19%), Positives = 389/952 (40%), Gaps = 141/952 (14%)
Query: 45 LREYEERINSMTSH-------FKNVKQELSITQSLCKARERETESEEHFKAIAQRELGRV 97
L+E E +INS+T KN +E+ C+ ER E K + Q +
Sbjct: 582 LKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLIL--ELGKKVEQTI--QY 637
Query: 98 KDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQM---NWDQQALEAWLEESAHKD 154
E+++ NE+ LE+ +++ + QKL+ L QM + D++ L A ++ S +++
Sbjct: 638 NSELEQKVNELTGGLEETLKEKD---QNDQKLEKLMVQMKVLSEDKEVLSAEVK-SLYEE 693
Query: 155 SDALTLQK----------YAQQDDNKIRALTLQLER----LTLECNQKRKILDNELTETI 200
++ L+ +K +Q++D ++ QLE+ + E + K+L+NE + +
Sbjct: 694 NNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKL 753
Query: 201 SAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKEN 260
+ +L ++ +E E E + + + G+ LA+I +E
Sbjct: 754 FVKTQLYGFLKEMGSEVSEDSE-----EKDVVNVLQAVGE------SLAKINEEKCNLAF 802
Query: 261 LVKEKIKFLESEIGNNTEFEKRISVADRKLLKC---RTAYQDHETSRIQLKGELDSLKAT 317
EK+ LE EI + + +++C ++ +D+E ++ L+ EL+ +++
Sbjct: 803 QRDEKVLELEKEIK---------CLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSE 853
Query: 318 VNRTSSDLEALRKNISKIKKD-------IHEETARLQKTKNHNE--------------II 356
SDL ++ K + + + E + K++ HNE ++
Sbjct: 854 KEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLL 913
Query: 357 QTK-----------LKEITEKTMSVEE----KATNLEDMLKEEEKDVKEVDVQLNLIKGV 401
+ K LK+ K+ SV+ LE+ ++ EK+ KE + ++N IK V
Sbjct: 914 EQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLV 973
Query: 402 LFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQL----------QKLDFETLKQQEIM 451
K +EL + + + V E+E RS L+ + + L E KQ E +
Sbjct: 974 AVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQL 1033
Query: 452 YSQDFHIQQVERRMSRLKGEINSEEKQ--ALEAKIVELRKSLEEKKSTCGLLETQIKKLH 509
+ E R+ L ++ + Q + + +L +E +S LLE QI ++
Sbjct: 1034 DVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQ 1093
Query: 510 NDLYFIKKAHSKNSDEKQSLM----TKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLK 565
+ K +K+ + T +NEL + + +L K K Q M E L+K
Sbjct: 1094 RAKAMVDKELEAEKLQKEQKIKEHATTVNEL----EELQVQLQKEKKQLQKTMQELELVK 1149
Query: 566 LEVKRTREMLHSKAEEVLSLEKRKQQL---YTAMEERTEEIKVHK----------TMLAS 612
+ ++T M A+ +++ Q+L +E+ +EIK+ K T L S
Sbjct: 1150 KDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQS 1209
Query: 613 QIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQ---AYYVIKAAQ 669
++ +++ I + ++ K ++ +GE E +Q Y I+ A+
Sbjct: 1210 SVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAE 1269
Query: 670 EKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQ- 728
E + + L + ++ + A + + L K VT + Y++++
Sbjct: 1270 ITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHN 1329
Query: 729 -LEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLD----VIEHLANNVKEKLSEKQAYSF 783
L++QK Q + +++ + +E +D ++ NN++ +SE Q
Sbjct: 1330 VLKQQKNK-----SMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQS 1384
Query: 784 QLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLV 843
+ E L+ + A+L +++ ++ E + ++ ++V+
Sbjct: 1385 EHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFR 1444
Query: 844 DIIEE-NTEIRIILQTYFQQ-SGLELPTASTKGSRQSSRSPSHTSLSARSSR 893
D + E R ++T QQ S +E K + ++RSP + S ++ R
Sbjct: 1445 DQVRHLQEEHRKTVETLQQQLSKMEAQLFQLK-NEPTTRSPVSSQQSLKNLR 1495
Score = 97.4 bits (241), Expect = 5e-20
Identities = 186/918 (20%), Positives = 379/918 (41%), Gaps = 132/918 (14%)
Query: 60 KNVKQELSITQSLCKARERETESEEHFKAIAQRELGR-VKDEIQRLENEMASILEKKSDK 118
K K+++ + Q KA+ R TE E+ + + + + D I+ L + ++L +K++
Sbjct: 32 KFAKKQMMLIQ---KAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAET 88
Query: 119 ENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQL 178
E K + +K + + + AHK+ + + Y ++ +N L +L
Sbjct: 89 EQQCLSL--KKENIKMKQEVEDSVTKMG---DAHKELEQSHIN-YVKEIEN----LKNEL 138
Query: 179 ERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRD 238
+ + ++ + L +L E ++ QLEL + K N ++ +K+ + IE++ R
Sbjct: 139 MAVRSKYSEDKANLQKQLEEAMNTQLELSEQL----KFQNNSEDNVKKLQEEIEKI--RP 192
Query: 239 GDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQ 298
G + ++ T EK+ V + +E+ N+ ++K I+ +LL+ + +Q
Sbjct: 193 GFEEQILYLQKQLDATTDEKKETVTQLQNIIEA---NSQHYQKNINSLQEELLQLKAIHQ 249
Query: 299 DH--------ETSRIQLKGELDSL---------------KATVNRTSSDLEALRKNISKI 335
+ E S + + E++ L K + +LE LRK S
Sbjct: 250 EEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNA 309
Query: 336 KKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKD---VKEVD 392
+D N+I L+E T V EK +LED LKE E +K+
Sbjct: 310 NQD--------------NQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEV 355
Query: 393 VQLNLIKGVLFKKAQELQTETMKEKAVLS---------------EIEGTRSSLKHLNHQL 437
+N +K L AQ ++ E E+ L IE +S L LN Q
Sbjct: 356 TYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQF 415
Query: 438 ------QKLDFETLKQQ---EIMYSQDFHIQQVERRMSRLKGEIN--SEEKQALEAKIVE 486
+ ++LK+Q EI + + E+ L EI E+ + L+ + E
Sbjct: 416 CYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQE 475
Query: 487 LRKSLEEKKSTCGLLETQI----KKLHNDLYFIKKAHSKNSDE-KQSLMTKINELNLFID 541
+ E + +L+T++ K+ + +K+ + + E +Q L T E + ++
Sbjct: 476 AILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLE 535
Query: 542 RSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTE 601
+++ +G + L+ + L+ E++ T + L K L ++ + +E +
Sbjct: 536 ----TVNRLQGENEKLLSQQELVP-ELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKIN 590
Query: 602 EIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQA 661
+ K ++++ +E +N + I +L + E + E E++
Sbjct: 591 SLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVE--QTIQYNSELEQK---- 644
Query: 662 YYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSD 721
V + EE +E D D K+ K ++ L +VL++ + + K+ SS+
Sbjct: 645 --VNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKL--SSE 700
Query: 722 EYELKIQLE---EQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANN--VKEKLS 776
+ +L LE QK V K I +L++ +Q M D + L N V++
Sbjct: 701 KKQLSRDLEVFLSQKEDVILK-----EHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFV 755
Query: 777 EKQAYSF------QLSKETEEQK--PKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKL 828
+ Q Y F ++S+++EE+ L+ V + AK+ +E L +DE + E + ++
Sbjct: 756 KTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEI 815
Query: 829 REMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQ-----SGLELPTASTKGSRQSSRSPS 883
+ +++ V E L ++ + + +++L+ ++ L+ K + + +R +
Sbjct: 816 KCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLEN 875
Query: 884 HTSLSARSSRSTSTSTSQ 901
L S + S S+
Sbjct: 876 QNLLIQVEEVSQTCSKSE 893
Score = 89.0 bits (219), Expect = 2e-17
Identities = 164/803 (20%), Positives = 320/803 (39%), Gaps = 113/803 (14%)
Query: 7 AELHWEDGFAIPVANEENKLLEDQLSKLKDERASL---QDELREYEERINSMTSHFKNVK 63
+E+H E +E K L +Q +L+D RA L +D L + N S K ++
Sbjct: 892 SEIHNEKEKCFIKEHENLKPLLEQ-KELRDRRAELILLKDSLAKSPSVKNDPLSSVKELE 950
Query: 64 QELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIF 123
+++ + CK +E + + A++EL + E Q ++ E+ S+ +S+K+
Sbjct: 951 EKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESL---RSEKDQLSA 1007
Query: 124 KATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQK-YAQQDDNKIRALTLQLERLT 182
+ G + N L K S+ L ++K A +++I LT QL T
Sbjct: 1008 SMRDLIQGAESYKN---------LLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNST 1058
Query: 183 LECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDID 242
L+C I+++ ++L+ + IE +Q ++
Sbjct: 1059 LQC----------------------------ETINSDNEDLLAR----IETLQSNAKLLE 1086
Query: 243 NCALELARIK---QETREKENLVKE-KIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQ 298
LE+ R K + E E L KE KIK + + E + ++ ++L K
Sbjct: 1087 VQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQLQKTM---- 1142
Query: 299 DHETSRIQLKGELDSLKATVNRTSSDLEALRKNISK------IKKDIHEETARLQKTKNH 352
E ++ + +L +N +D E L K +++ K + E+ ++QK K
Sbjct: 1143 -QELELVKKDAQQTTL---MNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQK-- 1196
Query: 353 NEIIQTKLKEITEKTMSVEEKATNLEDML---KEEEKDVKEVDVQLNLIKGVLFKKAQEL 409
E +Q ++ + EEK T ++ +L K+E D K+ + +++ L + +
Sbjct: 1197 QETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEAS 1256
Query: 410 QTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLK 469
Q + K L+EI +S KH H+ K E ++ Y Q Q E R ++ +
Sbjct: 1257 QQQVEVYKIQLAEI----TSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAE 1312
Query: 470 GEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSL 529
+ E ++ + ++ + K + K + E ++ + I + K D + +L
Sbjct: 1313 QATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNL 1372
Query: 530 MTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRK 589
++EL + L++ Q+ + ++ L RE L S E + ++
Sbjct: 1373 QINVSELQTLQSEHDTLLERHNKMLQETVSKEAEL-------REKLCSIQSENMMMKSEH 1425
Query: 590 QQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIE----KLKN----R 641
Q + + T + +V + Q+R++ +E +++LSK+E +LKN R
Sbjct: 1426 TQ---TVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTR 1482
Query: 642 YEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQV 701
+ + L E T + +EE + ++ A +LE Q+
Sbjct: 1483 SPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLE---QL 1539
Query: 702 LNSCNNNYK--------------QSFKKVTPSSDEYELKIQLEEQKRAV-DEKYRYKQRQ 746
LNS + Q T S+D ++ E A+ E+ + + +
Sbjct: 1540 LNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSE 1599
Query: 747 IRELQEDIQSMENTLDVIEHLAN 769
IR L+ + Q E + +E+L N
Sbjct: 1600 IRRLERN-QEREKSAANLEYLKN 1621
Score = 58.2 bits (139), Expect = 4e-08
Identities = 96/517 (18%), Positives = 211/517 (40%), Gaps = 84/517 (16%)
Query: 30 QLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKAI 89
Q + + E A + ++E +++ + + ++++QE+ I + + + E S +
Sbjct: 1154 QTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQ 1213
Query: 90 AQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEE 149
+ + ++K + + + E+A K+++ ++ I +A+ LK ++ QQ +E + +
Sbjct: 1214 YEEKNTKIKQLLVKTKKELAD--SKQAETDHLILQAS-----LKGELEASQQQVEVYKIQ 1266
Query: 150 SAHKDSDALTLQKY----AQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLE 205
A S+ + ++ A+Q + A ++ L EC + T++++ E
Sbjct: 1267 LAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAE-----QATVTSEFE 1321
Query: 206 LDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKE- 264
K ++HN ++KQ +N + +G KQE E L+ +
Sbjct: 1322 SYKV-----RVHN----VLKQQKNKSMSQAETEG-----------AKQEREHLEMLIDQL 1361
Query: 265 KIKFLESEIG---NNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKA----- 316
KIK +S+ N +E + S D L + Q+ + +L+ +L S+++
Sbjct: 1362 KIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMM 1421
Query: 317 ------TVNRTSSDLEALRKNISKIKKDIHEE------TARLQKTKNHNEIIQTKLKEIT 364
TV++ +S E LR + + + EE T + Q +K ++ Q K + T
Sbjct: 1422 KSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTT 1481
Query: 365 EKTMSVEEKATNLED-------------MLKEEEKDVKEVDVQLNLIKGVLFKKAQEL-- 409
+S ++ NL + + +EE + ++ D + + ++L
Sbjct: 1482 RSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLN 1541
Query: 410 -----------QTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHI 458
E KE+ V ++ T S HLN L++ + E + I
Sbjct: 1542 SPETKLEPPLWHAEFTKEELV-QKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEI 1600
Query: 459 QQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKK 495
+++ER R K N E + + + + L+ E ++
Sbjct: 1601 RRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERER 1637
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 128 bits (321), Expect = 3e-29
Identities = 179/809 (22%), Positives = 358/809 (44%), Gaps = 96/809 (11%)
Query: 8 ELHWEDGFAIPVANEE-NKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQEL 66
E H ++ A+ A E+ +K E SKL+ D + ++ ++ + + + +EL
Sbjct: 536 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 595
Query: 67 SITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEM---------------ASI 111
+ S K ET K ++ + EI+ L+N+ A +
Sbjct: 596 KV--SFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL 653
Query: 112 LEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKI 171
++ +KEN + KLD + DQ +E +E++ +K Q+ + K+
Sbjct: 654 MKVIKEKENSLEAIRSKLDKAE-----DQHLVE--MEDTLNK----------LQEAEIKV 696
Query: 172 RALTLQLERLTLECNQKRKILDN---ELTETISAQLELDKAAQDFRKIHNERQELIKQWE 228
+ +LE L +CN++ K++DN +L T L+LD + + +E ++L +Q E
Sbjct: 697 K----ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 752
Query: 229 NTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTE-FEKRISVAD 287
+Q++ + + + + + + I +E + +E L ++ SE+ E EK + +
Sbjct: 753 AAEKQIKHLEIEKNAESSKASSITRELQGRE-LKLTNLQENLSEVSQVKETLEKELQILK 811
Query: 288 RKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQ 347
K + + S + +L + N SSDLE LR+N++ ++ E+ R +
Sbjct: 812 EKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREE 871
Query: 348 KTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQ 407
+ E ++ + EI + + + T + D L+ +E+DV+E +QL L K
Sbjct: 872 QLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE--LQLKLTKANENASFL 929
Query: 408 ELQTETMKEKAVLSEIEGTR---SSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERR 464
+ E M KA S+ E + K L +L L+ K+ E ++Q Q+++ R
Sbjct: 930 QKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE----KKMETSHNQ---CQELKAR 982
Query: 465 MSRLKGEINSEEK---QALEAKIVELRKSLE-EKKSTCGLLETQIKKLHNDLYFIKKAH- 519
R E ++ + Q L+ +++ L+ ++ GLL+ ++++L K A
Sbjct: 983 YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ-ELEELRKQADKAKAAQT 1041
Query: 520 SKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKA 579
++++ + MTK L K+ + + D + E+NL K E+ +K+
Sbjct: 1042 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL-----KNVEEL--NKS 1094
Query: 580 EEVLSLEKRKQQLYTAMEERTEEIKVHKTMLA---SQIRYVDQERENISTEF---RERLS 633
+E+L++E +K MEE +EI+ K A Q+ + +E ++ E R+ ++
Sbjct: 1095 KELLTVENQK------MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVT 1148
Query: 634 KIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIY 693
+KL+ +L +L E +K ++ ++ A +EK LQ+ A + + + E+
Sbjct: 1149 SHQKLEEERSVLNNQLL----EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1204
Query: 694 ALENTLQVLNSCNNNYKQSFKKV-TPSSDEYE-------LKIQLEEQKRAVDEKYRYKQR 745
L N + VL N + K V T SD+ + L++QL+E KR +
Sbjct: 1205 KLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDT 1264
Query: 746 QIRELQEDIQSMENTLDVIEHLANNVKEK 774
Q ED ++ E+ +D + + +++ K
Sbjct: 1265 Q---ADEDERAQESQIDFLNSVIVDLQRK 1290
Score = 99.8 bits (247), Expect = 1e-20
Identities = 166/851 (19%), Positives = 348/851 (40%), Gaps = 103/851 (12%)
Query: 39 ASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKA---IAQRELG 95
+S+ + R +T +++S T +L +A + + + E A + + E+
Sbjct: 320 SSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVA 379
Query: 96 RVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNW-DQQALEAW--LEESAH 152
+ + +E E+A + + + + K+D L+ + D++ +E LEE
Sbjct: 380 KATSHVGEIEQELALA---RDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKR 436
Query: 153 KDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQD 212
K D + + T+ + +E + + E+ E + +LE +K A D
Sbjct: 437 KVEDLQFRVEEESITKGDLEVATVSEKSRIMELEKDLALRVQEVAE-LRRRLESNKPAGD 495
Query: 213 FRKIHNERQELIKQWENTIEQMQKRDGDIDNCAL-ELARIKQETREKENLVKEKIKFLES 271
+ QE+ E ++ + D + +L E ++ET +KE +K E
Sbjct: 496 VDMSLSLLQEISSLQEKL--EVTRTDHQREITSLKEHFGAREETHQKE--IKALYTATEK 551
Query: 272 EIGNNTEFEKRISVADRK--------LLKCRTAYQDHETSRIQLKGELDSLKATVNRTSS 323
N + ++ A+++ K TA H+ + +LK S + ++
Sbjct: 552 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKV---SFSKGLGTETA 608
Query: 324 DLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTK---------LKEITEKTMSVEEKA 374
+ L+ I K++ D E LQ ++ K +K I EK S+E
Sbjct: 609 EFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIR 668
Query: 375 TNLEDMLKEEEKDVKEVDVQLNLIKG--VLFKKAQELQTETMKEKAVL----SEIEGTRS 428
+ L+ K E++ + E++ LN ++ + K+ + LQ + ++ V+ S+++ T
Sbjct: 669 SKLD---KAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEE 725
Query: 429 SLKHLNHQLQ-----KLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAK 483
L L+ + K + + L+QQ + ++E+ K + E Q E K
Sbjct: 726 KLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELK 785
Query: 484 IVELRKSLEEKKSTCGLLETQIKK-LHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDR 542
+ L+++L E +Q+K+ L +L +K+ ++ S+E S+ + E + +
Sbjct: 786 LTNLQENLSEV--------SQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQ 837
Query: 543 SEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEE 602
E++ N+L ++++ RE L + ++R++QL A E+ +
Sbjct: 838 KEEQF--------------NMLSSDLEKLRENLADMEAKFREKDEREEQLIKAKEKLEND 883
Query: 603 IKVHKTML---ASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKT 659
I M +SQ+ ++ E + E K+ K L + + E++
Sbjct: 884 IAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQS 943
Query: 660 QAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPS 719
Q K +EK+EL+R K++ EK++ N Q L K +++ T
Sbjct: 944 QQEAAKKHEEEKKELER-------KLSDLEKKMETSHNQCQEL-------KARYERATSE 989
Query: 720 SDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQ 779
+ +I QK +D + +++ +E+ + L+ + A+ K + +
Sbjct: 990 TKTKHEEILQNLQKTLLDT-----EDKLKGAREENSGLLQELEELRKQADKAKAAQTAED 1044
Query: 780 AYSF--QLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQD-------IKLRE 830
A Q++KE E LE + AKL E+ LK+ + +EE + ++ ++
Sbjct: 1045 AMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKELLTVENQK 1104
Query: 831 MKQFHKVIDEM 841
M++F K I+ +
Sbjct: 1105 MEEFRKEIETL 1115
Score = 68.9 bits (167), Expect = 2e-11
Identities = 141/721 (19%), Positives = 280/721 (38%), Gaps = 109/721 (15%)
Query: 284 SVADRKLLKCRTAY----QDHETSRIQL------KGELDSLKATVNRTSSDLE-----AL 328
+VA + +C+ Y H+ ++I K + ++++ + TS+ L+ +
Sbjct: 256 AVAGTRYFQCQPKYGLFAPVHKVTKIGFPSTTPAKAKANAVRRVMATTSASLKRSPSASS 315
Query: 329 RKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKD- 387
++S + + +R + K+ T +++EK ++E +L E + +
Sbjct: 316 LSSMSSVASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLER 375
Query: 388 ---------VKEVDVQLNLIKG-----VLFKKAQELQTETMKEKAVLSEIEGTRSSLKHL 433
V E++ +L L + VL +A+ Q TM E A ++E L L
Sbjct: 376 AEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVE----LLNQL 431
Query: 434 NHQLQKL-DFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAK-IVELRKSL 491
+ +K+ D + ++E + D + V + SR+ + E+ AL + + ELR+ L
Sbjct: 432 EEEKRKVEDLQFRVEEESITKGDLEVATVSEK-SRI---MELEKDLALRVQEVAELRRRL 487
Query: 492 EEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAK 551
E K G ++ + L +K +D ++ + + + +KE+
Sbjct: 488 ESNKPA-GDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALY 546
Query: 552 GFKQDLMIEDNLLKLEVKRTRE-------MLHSKAEEVLS-----LEKRKQQLYTAMEER 599
+ L E+ LK +++ + + SK E ++ +E+ K +
Sbjct: 547 TATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTE 606
Query: 600 TEEIKVHKTMLASQIRYVDQERENISTE--------------FRERLSKIEKLKNRYEIL 645
T E KT + E EN+ + R +L K+ K K
Sbjct: 607 TAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEA 666
Query: 646 TVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEK-------EIYALENT 698
L ++ + + QE E +E + L AK N+ K ++ A E
Sbjct: 667 IRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEK 726
Query: 699 L---QVLNSCNNNYKQSFKKVTPSSDEYELKIQ-LEEQKRAVDEKYRYKQRQIR------ 748
L L ++ K KK+ + E +I+ LE +K A K R+++
Sbjct: 727 LLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKL 786
Query: 749 -ELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLT 807
LQE++ + + +E +KEK +E + + + +E KL + +Q L+
Sbjct: 787 TNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 846
Query: 808 KEIRLLKDT----------KDETMEEQDIKLRE-----MKQFHKVIDEMLVDIIEENTEI 852
++ L++ KDE EEQ IK +E + + K+ + + + N E+
Sbjct: 847 SDLEKLRENLADMEAKFREKDE-REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDEL 905
Query: 853 RIILQTYFQQSGLELPTASTKGSRQSS---RSPSHTSLSARSSRSTSTSTSQSSIKVLEL 909
R+ ++ EL TK + +S +S ++ A S+ + + K LE
Sbjct: 906 RL-----KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELER 960
Query: 910 K 910
K
Sbjct: 961 K 961
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 128 bits (321), Expect = 3e-29
Identities = 179/809 (22%), Positives = 358/809 (44%), Gaps = 96/809 (11%)
Query: 8 ELHWEDGFAIPVANEE-NKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQEL 66
E H ++ A+ A E+ +K E SKL+ D + ++ ++ + + + +EL
Sbjct: 571 ETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEEL 630
Query: 67 SITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEM---------------ASI 111
+ S K ET K ++ + EI+ L+N+ A +
Sbjct: 631 KV--SFSKGLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKL 688
Query: 112 LEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKI 171
++ +KEN + KLD + DQ +E +E++ +K Q+ + K+
Sbjct: 689 MKVIKEKENSLEAIRSKLDKAE-----DQHLVE--MEDTLNK----------LQEAEIKV 731
Query: 172 RALTLQLERLTLECNQKRKILDN---ELTETISAQLELDKAAQDFRKIHNERQELIKQWE 228
+ +LE L +CN++ K++DN +L T L+LD + + +E ++L +Q E
Sbjct: 732 K----ELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLE 787
Query: 229 NTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTE-FEKRISVAD 287
+Q++ + + + + + + I +E + +E L ++ SE+ E EK + +
Sbjct: 788 AAEKQIKHLEIEKNAESSKASSITRELQGRE-LKLTNLQENLSEVSQVKETLEKELQILK 846
Query: 288 RKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQ 347
K + + S + +L + N SSDLE LR+N++ ++ E+ R +
Sbjct: 847 EKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEKLRENLADMEAKFREKDEREE 906
Query: 348 KTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQ 407
+ E ++ + EI + + + T + D L+ +E+DV+E +QL L K
Sbjct: 907 QLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEE--LQLKLTKANENASFL 964
Query: 408 ELQTETMKEKAVLSEIEGTR---SSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERR 464
+ E M KA S+ E + K L +L L+ K+ E ++Q Q+++ R
Sbjct: 965 QKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDLE----KKMETSHNQ---CQELKAR 1017
Query: 465 MSRLKGEINSEEK---QALEAKIVELRKSLE-EKKSTCGLLETQIKKLHNDLYFIKKAH- 519
R E ++ + Q L+ +++ L+ ++ GLL+ ++++L K A
Sbjct: 1018 YERATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQ-ELEELRKQADKAKAAQT 1076
Query: 520 SKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKA 579
++++ + MTK L K+ + + D + E+NL K E+ +K+
Sbjct: 1077 AEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNL-----KNVEEL--NKS 1129
Query: 580 EEVLSLEKRKQQLYTAMEERTEEIKVHKTMLA---SQIRYVDQERENISTEF---RERLS 633
+E+L++E +K MEE +EI+ K A Q+ + +E ++ E R+ ++
Sbjct: 1130 KELLTVENQK------MEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEELGRSRDEVT 1183
Query: 634 KIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIY 693
+KL+ +L +L E +K ++ ++ A +EK LQ+ A + + + E+
Sbjct: 1184 SHQKLEEERSVLNNQLL----EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE 1239
Query: 694 ALENTLQVLNSCNNNYKQSFKKV-TPSSDEYE-------LKIQLEEQKRAVDEKYRYKQR 745
L N + VL N + K V T SD+ + L++QL+E KR +
Sbjct: 1240 KLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGNTDT 1299
Query: 746 QIRELQEDIQSMENTLDVIEHLANNVKEK 774
Q ED ++ E+ +D + + +++ K
Sbjct: 1300 Q---ADEDERAQESQIDFLNSVIVDLQRK 1325
Score = 98.2 bits (243), Expect = 3e-20
Identities = 168/858 (19%), Positives = 349/858 (40%), Gaps = 115/858 (13%)
Query: 40 SLQDELREYEERINSM--------------TSHFKNVKQELSITQSLCKARERETESEEH 85
+LQ+ L+E ++ I + TSH ++QEL++ + E E++
Sbjct: 352 ALQEALKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAK-- 409
Query: 86 FKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEA 145
+L + + R + E+ + LE++ K + ++ K + + A
Sbjct: 410 -----MDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVEEESITKGDLETQTKLEHA 464
Query: 146 WLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLE 205
++E T Q++ R T+ + +E + + E+ E + +LE
Sbjct: 465 RIKELEQSLLFEKTKADKLQRELEDTRVATVSEKSRIMELEKDLALRVQEVAE-LRRRLE 523
Query: 206 LDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCAL-ELARIKQETREKENLVKE 264
+K A D + QE+ E ++ + D + +L E ++ET +KE +K
Sbjct: 524 SNKPAGDVDMSLSLLQEISSLQEKL--EVTRTDHQREITSLKEHFGAREETHQKE--IKA 579
Query: 265 KIKFLESEIGNNTEFEKRISVADRK--------LLKCRTAYQDHETSRIQLKGELDSLKA 316
E N + ++ A+++ K TA H+ + +LK S
Sbjct: 580 LYTATEKLSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKV---SFSK 636
Query: 317 TVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTK---------LKEITEKT 367
+ +++ L+ I K++ D E LQ ++ K +K I EK
Sbjct: 637 GLGTETAEFAELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKE 696
Query: 368 MSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKG--VLFKKAQELQTETMKEKAVL----S 421
S+E + L+ K E++ + E++ LN ++ + K+ + LQ + ++ V+ S
Sbjct: 697 NSLEAIRSKLD---KAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTS 753
Query: 422 EIEGTRSSLKHLNHQLQ-----KLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEE 476
+++ T L L+ + K + + L+QQ + ++E+ K + E
Sbjct: 754 QLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRE 813
Query: 477 KQALEAKIVELRKSLEEKKSTCGLLETQIKK-LHNDLYFIKKAHSKNSDEKQSLMTKINE 535
Q E K+ L+++L E +Q+K+ L +L +K+ ++ S+E S+ + E
Sbjct: 814 LQGRELKLTNLQENLSEV--------SQVKETLEKELQILKEKFAEASEEAVSVQRSMQE 865
Query: 536 LNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTA 595
+ + E++ N+L ++++ RE L + ++R++QL A
Sbjct: 866 TVNKLHQKEEQF--------------NMLSSDLEKLRENLADMEAKFREKDEREEQLIKA 911
Query: 596 MEERTEEIKVHKTML---ASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPP 652
E+ +I M +SQ+ ++ E + E K+ K L +
Sbjct: 912 KEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM 971
Query: 653 EGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQS 712
+ E++Q K +EK+EL+R K++ EK++ N Q L K
Sbjct: 972 TVKAEQSQQEAAKKHEEEKKELER-------KLSDLEKKMETSHNQCQEL-------KAR 1017
Query: 713 FKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVK 772
+++ T + +I QK +D + +++ +E+ + L+ + A+ K
Sbjct: 1018 YERATSETKTKHEEILQNLQKTLLDT-----EDKLKGAREENSGLLQELEELRKQADKAK 1072
Query: 773 EKLSEKQAYSF--QLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQD----- 825
+ + A Q++KE E LE + AKL E+ LK+ + +EE +
Sbjct: 1073 AAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVEELNKSKEL 1132
Query: 826 --IKLREMKQFHKVIDEM 841
++ ++M++F K I+ +
Sbjct: 1133 LTVENQKMEEFRKEIETL 1150
Score = 74.3 bits (181), Expect = 5e-13
Identities = 141/716 (19%), Positives = 279/716 (38%), Gaps = 108/716 (15%)
Query: 262 VKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRT 321
V + S G TE R + + A ++ + QL E D +A V +
Sbjct: 322 VASSVSSRPSRTGLLTETSSRYARKISGTTALQEALKEKQQHIEQLLAERDLERAEVAKA 381
Query: 322 SSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDML 381
+S + + + ++ + +D H++ H ++ K+ ++ + + + L + L
Sbjct: 382 TSHVGEIEQELA-LARDGHDQ---------HVLELEAKMDQLRTMVEAADREKVELLNQL 431
Query: 382 KEEEKDVKEVDVQL---NLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQ 438
+EE++ V+++ ++ ++ KG +L+T+T E A + E+E Q
Sbjct: 432 EEEKRKVEDLQFRVEEESITKG-------DLETQTKLEHARIKELE-------------Q 471
Query: 439 KLDFETLKQQEIMYS-QDFHIQQVERRMSRLKGEINSEEKQALEAK-IVELRKSLEEKKS 496
L FE K ++ +D + V + SR+ + E+ AL + + ELR+ LE K
Sbjct: 472 SLLFEKTKADKLQRELEDTRVATVSEK-SRI---MELEKDLALRVQEVAELRRRLESNKP 527
Query: 497 TCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQD 556
G ++ + L +K +D ++ + + + +KE+ +
Sbjct: 528 A-GDVDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGAREETHQKEIKALYTATEK 586
Query: 557 LMIEDNLLKLEVKRTRE-------MLHSKAEEVLS-----LEKRKQQLYTAMEERTEEIK 604
L E+ LK +++ + + SK E ++ +E+ K + T E
Sbjct: 587 LSKENESLKSKLEHANKENSDVIALWKSKLETAIASHQQAMEELKVSFSKGLGTETAEFA 646
Query: 605 VHKTMLASQIRYVDQERENISTE--------------FRERLSKIEKLKNRYEILTVVML 650
KT + E EN+ + R +L K+ K K L
Sbjct: 647 ELKTQIEKMRLDYQHEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKL 706
Query: 651 PPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEK-------EIYALENTL---Q 700
++ + + QE E +E + L AK N+ K ++ A E L
Sbjct: 707 DKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLD 766
Query: 701 VLNSCNNNYKQSFKKVTPSSDEYELKIQ-LEEQKRAVDEKYRYKQRQIR-------ELQE 752
L ++ K KK+ + E +I+ LE +K A K R+++ LQE
Sbjct: 767 ALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTNLQE 826
Query: 753 DIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRL 812
++ + + +E +KEK +E + + + +E KL + +Q L+ ++
Sbjct: 827 NLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSDLEK 886
Query: 813 LKDT----------KDETMEEQDIKLRE-----MKQFHKVIDEMLVDIIEENTEIRIILQ 857
L++ KDE EEQ IK +E + + K+ + + + N E+R+
Sbjct: 887 LRENLADMEAKFREKDE-REEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRL--- 942
Query: 858 TYFQQSGLELPTASTKGSRQSS---RSPSHTSLSARSSRSTSTSTSQSSIKVLELK 910
++ EL TK + +S +S ++ A S+ + + K LE K
Sbjct: 943 --KERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERK 996
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 128 bits (321), Expect = 3e-29
Identities = 169/899 (18%), Positives = 384/899 (42%), Gaps = 111/899 (12%)
Query: 20 ANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVK-QELSITQSLCKARER 78
A +E +++ + K+E A + +E EE++ S+ +++ Q S T++L A ER
Sbjct: 849 AEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEER 908
Query: 79 ETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNW 138
E K + + ++ + + ++ E + ++ KK + E+ + +D L+ +
Sbjct: 909 -CEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLT- 966
Query: 139 DQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQ---LERLTLECNQKRKILDNE 195
++K +NK++ L+ + LE + +++K L
Sbjct: 967 --------------------KVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQEA 1006
Query: 196 LTETI-SAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQE 254
+T+ Q+E DK KI+ + ++ E ++EQ +K D++ R K++
Sbjct: 1007 HQQTLDDLQVEEDK-VNGLIKINAKLEQQTDDLEGSLEQEKKLRADLE-------RAKRK 1058
Query: 255 TREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSL 314
+ +E I LE++ + E+++ + +L + + D + +Q + ++ L
Sbjct: 1059 LEGDLKMSQESIMDLEND---KQQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKEL 1115
Query: 315 KATVNRTSSDLEA---LRKNISKIKKDIHEE---------------TARLQKTKNHNEII 356
+A + ++EA LR I K + D+ E +A+++ K
Sbjct: 1116 QARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEF 1175
Query: 357 QTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKE 416
Q +++ E T+ E A L K++ V E+ Q++ ++ V K +E M+
Sbjct: 1176 QKMRRDLEEATLQHEATAATLR---KKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEI 1232
Query: 417 KAVLSEIEGTRSSLKHLNHQLQKLD--FETLKQQEIMYSQDFH-IQQVERRMSRLKGEIN 473
+ S IE S ++ + ++ F +K ++ +Q H + + R+ GE++
Sbjct: 1233 DDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELS 1292
Query: 474 -------------SEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHS 520
++ KQAL ++ EL++ +EE+ + ++ +D +++ +
Sbjct: 1293 HRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYE 1352
Query: 521 KNSDEKQSLMTKINELNLFID--RSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSK 578
+ + K L +++ N + R++ E D + ++L L ++ E +
Sbjct: 1353 EEQEAKAELQRALSKANSEVAQWRTKYETDAIQR-TEELEEAKKKLAQRLQEAEENTETA 1411
Query: 579 AEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKL 638
+ SLEK KQ+L +E+ +++ T A+ +D+++ N E K+++
Sbjct: 1412 NSKCASLEKTKQRLQGEVEDLMRDLERSHTACAT----LDKKQRNFDKVLAEWKQKLDES 1467
Query: 639 KNRYE--------ILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEK 690
+ E + T + EE ++ +E + LQ E L +I + K
Sbjct: 1468 QAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLR--RENKNLQEEISDLTEQIAETGK 1525
Query: 691 EIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKI-----QLEEQKRAVDEKYRYKQR 745
+ E T +++ ++ + + ++V S + E KI +L + K +D K K
Sbjct: 1526 NLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRKVIEKDE 1585
Query: 746 QIRELQEDIQ----SMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTK 801
+I +L+ + Q ++++ LD E + N +L +K + + E + +L +
Sbjct: 1586 EIEQLKRNSQRAAEALQSVLDA-EIRSRNDALRLKKK------MEGDLNEMEIQLGHSNR 1638
Query: 802 QCAKLTKEIRLLKDTKDETMEEQDIKLR---EMKQFHKVIDEMLVDIIEENTEIRIILQ 857
Q A+ K +R ++ ++ D LR ++K+ +++ ++EE E+++ L+
Sbjct: 1639 QMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVALE 1697
Score = 119 bits (298), Expect = 1e-26
Identities = 171/837 (20%), Positives = 354/837 (42%), Gaps = 111/837 (13%)
Query: 21 NEENKLLEDQLSKLKDERASLQ-------DELREYEERINSMTSHFKNVKQELSITQSLC 73
+EE LE+ +SKL E+ SLQ D+L+ E+++N + ++Q+ +
Sbjct: 983 SEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSL 1042
Query: 74 KARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLK 133
+ ++ E K + +L ++ I LEN+ I EK KE + + K+D +
Sbjct: 1043 EQEKKLRADLERAKRKLEGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQ 1102
Query: 134 ---CQMNWDQQALEAWLEESAHKDSDALTLQ-KYAQQDDNKIRALTLQLERLTLECNQKR 189
Q + L+A +EE + TL+ K +Q + R L ERL
Sbjct: 1103 VHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARELEEISERL-------- 1154
Query: 190 KILDNELTETISAQLELDKAAQ-DFRKIHNERQELIKQWENTIEQMQKRDGD-------- 240
E + SAQ+E++K + +F+K+ + +E Q E T ++K+ D
Sbjct: 1155 ----EEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQ 1210
Query: 241 IDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDH 300
IDN L R+KQ+ ++++ +K +I + S I
Sbjct: 1211 IDN----LQRVKQKLEKEKSELKMEIDDMASNI--------------------------- 1239
Query: 301 ETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNH-NEIIQTK 359
+ + K ++ TV S+++A + +++ D++ + ARLQ + ++ K
Sbjct: 1240 -EALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEEK 1298
Query: 360 LKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAV 419
I++ T S + LE++ ++ E++ K + A LQ+ +
Sbjct: 1299 ESLISQLTKSKQALTQQLEELKRQMEEETKAKNAM-----------AHALQSSRHDCDLL 1347
Query: 420 LSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQA 479
+ E + + L L K + E + Q Y D IQ+ E E K+
Sbjct: 1348 REQYEEEQEAKAELQRALSKANSE-VAQWRTKYETD-AIQRTEEL---------EEAKKK 1396
Query: 480 LEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLF 539
L ++ E ++ E S C LE ++L ++ + + ++ +L K +
Sbjct: 1397 LAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKV 1456
Query: 540 IDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEER 599
+ +++LD+++ + E L E+ + R +++ +L + + L + +
Sbjct: 1457 LAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDL 1516
Query: 600 TEEI-KVHKTMLASQ--IRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEE 656
TE+I + K + ++ + V+QE+ ++ E +E +++ + + + + E
Sbjct: 1517 TEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSEL 1576
Query: 657 EKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKV 716
++ VI+ +E E+L+R +++ AL++ L N+ + KK+
Sbjct: 1577 DRK----VIEKDEEIEQLKR----------NSQRAAEALQSVLDAEIRSRNDALRLKKKM 1622
Query: 717 TPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLS 776
D E++IQL R + E Q+ +R +Q ++ + LD ++KE+L+
Sbjct: 1623 --EGDLNEMEIQLGHSNRQMAE----TQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLA 1676
Query: 777 EKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQ 833
+ + L +E EE K LE+ T++ +L+++ L + + + Q+ L K+
Sbjct: 1677 IVERRNGLLLEELEEMKVALEQ-TERTRRLSEQELLDASDRVQLLHSQNTSLINTKK 1732
Score = 97.8 bits (242), Expect = 4e-20
Identities = 135/721 (18%), Positives = 298/721 (41%), Gaps = 60/721 (8%)
Query: 195 ELTETISAQLELDKAAQDFRKIHNERQ-ELIKQWENTIEQMQKRDGDIDNCALELARIKQ 253
EL + + + EL++ + N+ Q ++ + EN ++ ++ +G I + L A++K+
Sbjct: 866 ELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKE 925
Query: 254 ETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDS 313
T LE E N+E + + K + D E + +++ E +
Sbjct: 926 LTER-----------LEEEEEMNSELVAKKRNLEDKCSSLKRDIDDLELTLTKVEKEKHA 974
Query: 314 LKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEK 373
+ V S ++ AL +NISK+ K+ Q+T + ++ + K+ + + +E++
Sbjct: 975 TENKVKNLSEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQ 1034
Query: 374 ATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHL 433
+LE L++E+K +++ ++G L K +QE + +K + E LK
Sbjct: 1035 TDDLEGSLEQEKKLRADLERAKRKLEGDL-KMSQESIMDLENDKQQIEE------KLKKK 1087
Query: 434 NHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSE-------EKQA--LEAKI 484
+L +L + +Q I++++ R+ L+ EI +E EKQ L ++
Sbjct: 1088 EFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLAREL 1147
Query: 485 VELRKSLEEKKSTCGL-------LETQIKKLHNDLYFIKKAH--------SKNSDEKQSL 529
E+ + LEE E + +K+ DL H K +D L
Sbjct: 1148 EEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKQADSVAEL 1207
Query: 530 MTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLL---KLEVKRTREMLHSKAEEVLSLE 586
+I+ L + EKE + K D+ L K ++RT + + E+ + +
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKD 1267
Query: 587 KRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILT 646
+++ QL + + ++ L+ ++ + ++ + ++E+LK + E T
Sbjct: 1268 EQQTQLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEET 1327
Query: 647 VVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQV-LNSC 705
+ ++ + Q +EE + + + L ++KA E+ +
Sbjct: 1328 KAKNAMAHALQSSRHDCDLLREQYEEEQEAKAE-LQRALSKANSEVAQWRTKYETDAIQR 1386
Query: 706 NNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYK-QRQIRELQEDIQSMENTLDVI 764
+++ KK+ E E + K A EK + + Q ++ +L D++ +
Sbjct: 1387 TEELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATL 1446
Query: 765 EHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQ 824
+ N + L+E ++ +E + +LE K+ L+ E+ +++ +E +++
Sbjct: 1447 DKKQRNFDKVLAE-------WKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL 1499
Query: 825 DIKLREMKQFHKVIDEMLVDIIEENTEIRIILQT----YFQQSGLELPTASTKGSRQSSR 880
+ RE K + I ++ I E ++ +T ++S L++ +GS +
Sbjct: 1500 ETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEE 1559
Query: 881 S 881
S
Sbjct: 1560 S 1560
Score = 86.3 bits (212), Expect = 1e-16
Identities = 115/562 (20%), Positives = 257/562 (45%), Gaps = 51/562 (9%)
Query: 333 SKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVD 392
++ +K++ ++TK + + KE+ EK +S+ ++ +L+ ++ E +++ + +
Sbjct: 847 AEAEKEMATMKEDFERTKEELARSEARRKELEEKMVSLLQEKNDLQLQVQSETENLMDAE 906
Query: 393 VQL-NLIKG--VLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQE 449
+ LIK +L K +EL +E+ + SE+ + +L+ L K D + L+
Sbjct: 907 ERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSL-KRDIDDLELTL 965
Query: 450 IMYSQDFHIQQVERRMSRLKGEINSEEKQALE---AKIVELRKSLEE-KKSTCGLLETQI 505
++ H E ++ L SEE ALE +K+ + +KSL+E + T L+ +
Sbjct: 966 TKVEKEKH--ATENKVKNL-----SEEMTALEENISKLTKEKKSLQEAHQQTLDDLQVEE 1018
Query: 506 KKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLM------- 558
K+ N L I + +D+ + + + +L ++R++++L+ Q+ +
Sbjct: 1019 DKV-NGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLENDK 1077
Query: 559 --IEDNLLKLEVKRTREMLHSKAEEVLSL--EKRKQQLYTAMEERTEEIKVHKTMLASQI 614
IE+ L K E + ++ E+V SL +K+ ++L +EE EEI+ T+ A
Sbjct: 1078 QQIEEKLKKKEFELSQLQAKIDDEQVHSLQFQKKIKELQARIEELEEEIEAEHTLRAK-- 1135
Query: 615 RYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEEL 674
++++R +++ E E ++E+ + E E +K + ++ EE
Sbjct: 1136 --IEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMR--------RDLEEA 1185
Query: 675 QREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKR 734
+ + A + K + + A E Q+ N KQ +K ++ ELK+++++
Sbjct: 1186 TLQHEATAATLRKKQADSVA-ELGEQIDNL--QRVKQKLEK-----EKSELKMEIDDMAS 1237
Query: 735 AVDEKYRYK---QRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEE 791
++ + K +R R +++ ++ + L +++ + + Q + +LS EE
Sbjct: 1238 NIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHDLNMQKARLQTQNGELSHRVEE 1297
Query: 792 QKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTE 851
++ + ++TK LT+++ LK +E + ++ ++ D +L + EE E
Sbjct: 1298 KESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCD-LLREQYEEEQE 1356
Query: 852 IRIILQTYFQQSGLELPTASTK 873
+ LQ ++ E+ TK
Sbjct: 1357 AKAELQRALSKANSEVAQWRTK 1378
Score = 45.4 bits (106), Expect = 2e-04
Identities = 87/443 (19%), Positives = 171/443 (38%), Gaps = 109/443 (24%)
Query: 29 DQLSKLKDERASLQDELREYEERINSMTSHF-------KNVKQELSITQSLCKARERETE 81
DQL L+ E +LQ+E+ + E+I + K V+QE S Q + E E
Sbjct: 1497 DQLETLRRENKNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLE 1556
Query: 82 SEEHFKAIAQRELGRVKDEI------------------QRLENEMASILEKKSDKENGIF 123
EE Q EL +VK E+ QR + S+L+ + N
Sbjct: 1557 HEESKILRVQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDAL 1616
Query: 124 KATQKLDG----LKCQMNWDQQAL-----------------EAWLEESAHKDSDA----- 157
+ +K++G ++ Q+ + + + L+++ + D
Sbjct: 1617 RLKKKMEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLA 1676
Query: 158 ------------LTLQKYAQQDDNKIRALTLQL------------ERLTLECNQKRKI-- 191
L K A + + R L+ Q + T N K+K+
Sbjct: 1677 IVERRNGLLLEELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEA 1736
Query: 192 --------LDNELTETISAQLELDKA-------AQDFRK-----IHNERQELIKQWENTI 231
++N + E+ +A+ + KA A++ +K H ER + K E T+
Sbjct: 1737 DIAQCQAEVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMK--KNLEQTV 1794
Query: 232 EQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLL 291
+ +Q R + + AL+ K++ ++ EN V+E L+ E E K +RK+
Sbjct: 1795 KDLQHRLDEAEQLALKGG--KKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVK 1852
Query: 292 KCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRK----NISKIKKDIHEETARLQ 347
+ ++ + ++L+ +D L+A V E + +S+ ++ HE L+
Sbjct: 1853 EMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQHE----LE 1908
Query: 348 KTKNHNEIIQTKLKEITEKTMSV 370
+ +I ++++ ++ K+ V
Sbjct: 1909 EAAERADIAESQVNKLRAKSRDV 1931
Score = 41.6 bits (96), Expect = 0.004
Identities = 65/303 (21%), Positives = 127/303 (41%), Gaps = 59/303 (19%)
Query: 7 AELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQEL 66
++LH +D A N+ L++QL+ ++ L +EL E + +
Sbjct: 1657 SQLHLDD------ALRSNEDLKEQLAIVERRNGLLLEELEEMKVAL-------------- 1696
Query: 67 SITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKAT 126
E E + ++++EL D +Q L ++ S++ K E I +
Sbjct: 1697 --------------EQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQ 1742
Query: 127 QKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECN 186
+++ N Q++ A EE A K A+T ++ K + + LER+
Sbjct: 1743 AEVE------NSIQESRNA--EEKAKK---AITDAAMMAEELKKEQDTSAHLERMKKNLE 1791
Query: 187 QKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCAL 246
Q K L + L E + QL L + +K+ N +EL EN ++ QKR + A
Sbjct: 1792 QTVKDLQHRLDE--AEQLALKGGKKQIQKLENRVREL----ENELDVEQKRGAEALKGAH 1845
Query: 247 ELAR-IKQETREKEN------LVKEKIKFLESEIGN-NTEFEKRISVADRKLLKCRTAYQ 298
+ R +K+ T + E +++ + L++++ + + E+ A+ +L +CR
Sbjct: 1846 KYERKVKEMTYQAEEDHKNILRLQDLVDKLQAKVKSYKRQAEEAEEQANTQLSRCRRVQH 1905
Query: 299 DHE 301
+ E
Sbjct: 1906 ELE 1908
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 125 bits (315), Expect = 1e-28
Identities = 188/898 (20%), Positives = 379/898 (42%), Gaps = 156/898 (17%)
Query: 28 EDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETES-EEHF 86
++Q+ +L+D +Q + E E ++ M +HF +K+ L T R TE ++
Sbjct: 476 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHL--TSEAASGNHRLTEELKDQL 533
Query: 87 KAI------AQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKL--DGLKCQMNW 138
K + A E+G+++++I+ +NEM I+E+ E + + ++L + C+M
Sbjct: 534 KDLKVKYEGASAEVGKLRNQIK--QNEM--IVEEFKRDEGKLIEENKRLQKELSMCEMER 589
Query: 139 DQQALEAW-LEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELT 197
+++ + +E A + S L L A++ +N +L+ ++ + + + + L+
Sbjct: 590 EKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLS 649
Query: 198 ETISAQLELDKA-AQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETR 256
E + EL+ A+ + + E E +K +++++ G++ EL +K +T
Sbjct: 650 EIRQLKRELENVKAKLAQHVKPEEHEQVK------SRLEQKSGELGKKITELT-LKNQTL 702
Query: 257 EKE--------NLVKEKIKFLESEIGNN------TEFEKR-----ISVADRKLLKCRTAY 297
+KE L+KE+ L E+ N+ +E K+ I +RKLL Y
Sbjct: 703 QKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 762
Query: 298 QDHETSRIQLKGELDSLKATVNRTSS----------DLEALRKNISKIKKDIHE------ 341
+ + +L E DSL V+R + ++ AL+ NI ++KK + E
Sbjct: 763 TEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCG 822
Query: 342 -----------ETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDM-LKEEEKDVK 389
E L+K + N+ + K E + T++ TN E + +K++ +D+
Sbjct: 823 EDQEKIHALTSENTNLKKMMS-NQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN 881
Query: 390 EVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLK------------------ 431
+ V++ +L + + Q + E L+E E SSL
Sbjct: 882 QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYR 941
Query: 432 ---------HLNHQLQKLDFETLKQ-QEIMYSQDFHIQQVERRMSRLKGEIN---SEEKQ 478
H + QK + +T+++ ++ Y+ ++ ER+ + E+ SE+ Q
Sbjct: 942 KGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQ 1001
Query: 479 ALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNL 538
E++K+ +E + T K L + I+K+H + +++L K +ELN
Sbjct: 1002 KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH----EMERALSRKTDELNK 1057
Query: 539 FIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEE 598
+ ++ + K K+ L+ E+ E+ + +L + + +E K+ L +E
Sbjct: 1058 QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIEN 1117
Query: 599 RTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEK 658
EE+K S R ++E++ + +K+ +L E +K
Sbjct: 1118 LKEELK-------SMQRCYEKEQQTV--------TKLHQLL---------------ENQK 1147
Query: 659 TQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKK--- 715
+ + + Q KE ++E + A + + E+E + L S N KQ+ KK
Sbjct: 1148 NSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLET 1207
Query: 716 --VTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKE 773
V S K LE Q +++EK R+ E+ E++ H
Sbjct: 1208 REVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVL----------HAKKKEIS 1257
Query: 774 KLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREM 831
EK+ F + +E ++QK ER K +T+ R ++++ + +E +D K+ E+
Sbjct: 1258 AKDEKELLHFSIEQEIKDQK---ERCDKSLTTITELQRRIQESAKQ-IEAKDNKITEL 1311
Score = 82.0 bits (201), Expect = 2e-15
Identities = 141/724 (19%), Positives = 302/724 (41%), Gaps = 110/724 (15%)
Query: 23 ENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQEL-SITQSLCKARERETE 81
+NKLL++Q L E + L+ E+ S + ++ ++L +TQ K E++ E
Sbjct: 712 DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ---KYTEKKLE 768
Query: 82 SEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKE-----NGIFKATQKLDGLKCQM 136
E K + + + + ++ RLE + +K +KE + I + ++L LK +
Sbjct: 769 ME---KLLLEND--SLSKDVSRLETVF--VPPEKHEKEIIALKSNIVELKKQLSELKKKC 821
Query: 137 NWDQQALEAWLEESAH--------------KDSDALTLQKYAQQDDNKIRALTLQLERLT 182
DQ+ + A E+ + + +TL + + ++ + + E +
Sbjct: 822 GEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN 881
Query: 183 LE---CNQKRKILDNELTETISA-----------QLELDKAAQDFRKIHNERQELIKQWE 228
E K +IL L T + + ++ +Q RK+ + E++ +
Sbjct: 882 QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANY- 940
Query: 229 NTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADR 288
R G + L A IK + +E + ++E IK + I + E E++ ++
Sbjct: 941 --------RKGQEEIVTLH-AEIKAQKKELDT-IQECIKVKYAPIVSFEECERKFKATEK 990
Query: 289 KLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQK 348
+L +T + + E V + + + L+K I ++KD+ ++T ++K
Sbjct: 991 ELKD----QLSEQTQKYSVSEE------EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK 1040
Query: 349 TKNHNEIIQTKLKEITEKTMSVEEKATNL----EDMLKEEEKDVKEVDVQLNLIKGVLFK 404
+ + K E+ ++ + +K T + E +++E K E+ NL++ K
Sbjct: 1041 SHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQ----K 1096
Query: 405 KAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERR 464
+ L+ +K++ IE + LK + +K K +++ +Q +
Sbjct: 1097 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQ---------K 1147
Query: 465 MSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSD 524
S + + + K+A E ++ ++ SL EK+ ++ N + + K S+ +
Sbjct: 1148 NSSVPLAEHLQIKEAFEKEVGIIKASLREKE----------EESQNKMEEVSKLQSEVQN 1197
Query: 525 EKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKR---TREMLHSKAEE 581
KQ+L K E +D S+ + K+ Q + + L L K E+LH+K +E
Sbjct: 1198 TKQAL--KKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKE 1255
Query: 582 VLSLEKRKQQLYTAME-------ERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSK 634
+ S + K+ L+ ++E ER ++ T L +I+ ++ E + E L+
Sbjct: 1256 I-SAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLND 1314
Query: 635 IEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYA 694
+E+LK L+ + G K Q+ + + + L+++ A ++ +E+ A
Sbjct: 1315 VERLKQALNGLSQLTY-TSGNPTKRQSQLIDTLQHQVKSLEQQ----LADADRQHQEVIA 1369
Query: 695 LENT 698
+ T
Sbjct: 1370 IYRT 1373
Score = 57.8 bits (138), Expect = 5e-08
Identities = 108/480 (22%), Positives = 195/480 (40%), Gaps = 90/480 (18%)
Query: 19 VANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARER 78
V+ EE K + + KLK E +LQ +LR+ K V E K+ E
Sbjct: 1005 VSEEEVKKNKQENDKLKKEIFTLQKDLRD------------KTVLIE--------KSHEM 1044
Query: 79 ETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNW 138
E R L R DE L ++ + +K ++ +N
Sbjct: 1045 E------------RALSRKTDE---LNKQLKDLSQKYTEVKN------------------ 1071
Query: 139 DQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTE 198
E +EE+A + S+ L +Q Q+ + Q+E L N + L EL
Sbjct: 1072 ---VKEKLVEENAKQTSEILAVQNLLQKQHVPLE----QVEALKKSLNGTIENLKEELK- 1123
Query: 199 TISAQLELDKAAQDFRKIHNERQELIKQWENT----IEQMQKRDGDIDNCALELARIKQE 254
S Q +K Q K+H +L++ +N+ E +Q ++ + A ++++
Sbjct: 1124 --SMQRCYEKEQQTVTKLH----QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREK 1177
Query: 255 TREKENLVKEKIKFLESEIGNNTEFEKRISVAD-RKLLKCRTAYQDHETSRIQLKGELDS 313
E +N ++E K L+SE+ N + K++ + L K + D ET L +L +
Sbjct: 1178 EEESQNKMEEVSK-LQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1236
Query: 314 LKATVNRTSSD-LEALRKNIS-KIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVE 371
L + L A +K IS K +K++ + Q+ K+ E L ITE ++
Sbjct: 1237 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE-QEIKDQKERCDKSLTTITELQRRIQ 1295
Query: 372 EKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLK 431
E A +E ++ + E+ + +K L +Q T K I+ + +K
Sbjct: 1296 ESAKQIE----AKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVK 1351
Query: 432 HLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSL 491
L QL D + QE++ H+ +S +G ++ + ++AL +I+++R+ L
Sbjct: 1352 SLEQQLADAD---RQHQEVIAIYRTHL------LSAAQGHMDEDVQEAL-LQIIQMRQGL 1401
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 125 bits (315), Expect = 1e-28
Identities = 188/898 (20%), Positives = 379/898 (42%), Gaps = 156/898 (17%)
Query: 28 EDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETES-EEHF 86
++Q+ +L+D +Q + E E ++ M +HF +K+ L T R TE ++
Sbjct: 489 DEQIKQLEDALKDVQKRMYESEGKVKQMQTHFLALKEHL--TSEAASGNHRLTEELKDQL 546
Query: 87 KAI------AQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKL--DGLKCQMNW 138
K + A E+G+++++I+ +NEM I+E+ E + + ++L + C+M
Sbjct: 547 KDLKVKYEGASAEVGKLRNQIK--QNEM--IVEEFKRDEGKLIEENKRLQKELSMCEMER 602
Query: 139 DQQALEAW-LEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELT 197
+++ + +E A + S L L A++ +N +L+ ++ + + + + L+
Sbjct: 603 EKKGRKVTEMEGQAKELSAKLALSIPAEKFENMKSSLSNEVNEKAKKLVEMEREHEKSLS 662
Query: 198 ETISAQLELDKA-AQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETR 256
E + EL+ A+ + + E E +K +++++ G++ EL +K +T
Sbjct: 663 EIRQLKRELENVKAKLAQHVKPEEHEQVK------SRLEQKSGELGKKITELT-LKNQTL 715
Query: 257 EKE--------NLVKEKIKFLESEIGNN------TEFEKR-----ISVADRKLLKCRTAY 297
+KE L+KE+ L E+ N+ +E K+ I +RKLL Y
Sbjct: 716 QKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKY 775
Query: 298 QDHETSRIQLKGELDSLKATVNRTSS----------DLEALRKNISKIKKDIHE------ 341
+ + +L E DSL V+R + ++ AL+ NI ++KK + E
Sbjct: 776 TEKKLEMEKLLLENDSLSKDVSRLETVFVPPEKHEKEIIALKSNIVELKKQLSELKKKCG 835
Query: 342 -----------ETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDM-LKEEEKDVK 389
E L+K + N+ + K E + T++ TN E + +K++ +D+
Sbjct: 836 EDQEKIHALTSENTNLKKMMS-NQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN 894
Query: 390 EVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLK------------------ 431
+ V++ +L + + Q + E L+E E SSL
Sbjct: 895 QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANYR 954
Query: 432 ---------HLNHQLQKLDFETLKQ-QEIMYSQDFHIQQVERRMSRLKGEIN---SEEKQ 478
H + QK + +T+++ ++ Y+ ++ ER+ + E+ SE+ Q
Sbjct: 955 KGQEEIVTLHAEIKAQKKELDTIQECIKVKYAPIVSFEECERKFKATEKELKDQLSEQTQ 1014
Query: 479 ALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNL 538
E++K+ +E + T K L + I+K+H + +++L K +ELN
Sbjct: 1015 KYSVSEEEVKKNKQENDKLKKEIFTLQKDLRDKTVLIEKSH----EMERALSRKTDELNK 1070
Query: 539 FIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEE 598
+ ++ + K K+ L+ E+ E+ + +L + + +E K+ L +E
Sbjct: 1071 QLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQKQHVPLEQVEALKKSLNGTIEN 1130
Query: 599 RTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEK 658
EE+K S R ++E++ + +K+ +L E +K
Sbjct: 1131 LKEELK-------SMQRCYEKEQQTV--------TKLHQLL---------------ENQK 1160
Query: 659 TQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKK--- 715
+ + + Q KE ++E + A + + E+E + L S N KQ+ KK
Sbjct: 1161 NSSVPLAEHLQIKEAFEKEVGIIKASLREKEEESQNKMEEVSKLQSEVQNTKQALKKLET 1220
Query: 716 --VTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKE 773
V S K LE Q +++EK R+ E+ E++ H
Sbjct: 1221 REVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVL----------HAKKKEIS 1270
Query: 774 KLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREM 831
EK+ F + +E ++QK ER K +T+ R ++++ + +E +D K+ E+
Sbjct: 1271 AKDEKELLHFSIEQEIKDQK---ERCDKSLTTITELQRRIQESAKQ-IEAKDNKITEL 1324
Score = 82.0 bits (201), Expect = 2e-15
Identities = 141/724 (19%), Positives = 302/724 (41%), Gaps = 110/724 (15%)
Query: 23 ENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQEL-SITQSLCKARERETE 81
+NKLL++Q L E + L+ E+ S + ++ ++L +TQ K E++ E
Sbjct: 725 DNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQ---KYTEKKLE 781
Query: 82 SEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKE-----NGIFKATQKLDGLKCQM 136
E K + + + + ++ RLE + +K +KE + I + ++L LK +
Sbjct: 782 ME---KLLLEND--SLSKDVSRLETVF--VPPEKHEKEIIALKSNIVELKKQLSELKKKC 834
Query: 137 NWDQQALEAWLEESAH--------------KDSDALTLQKYAQQDDNKIRALTLQLERLT 182
DQ+ + A E+ + + +TL + + ++ + + E +
Sbjct: 835 GEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFEDIN 894
Query: 183 LE---CNQKRKILDNELTETISA-----------QLELDKAAQDFRKIHNERQELIKQWE 228
E K +IL L T + + ++ +Q RK+ + E++ +
Sbjct: 895 QEFVKIKDKNEILKRNLENTQNQIKAEYISLAEHEAKMSSLSQSMRKVQDSNAEILANY- 953
Query: 229 NTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADR 288
R G + L A IK + +E + ++E IK + I + E E++ ++
Sbjct: 954 --------RKGQEEIVTLH-AEIKAQKKELDT-IQECIKVKYAPIVSFEECERKFKATEK 1003
Query: 289 KLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQK 348
+L +T + + E V + + + L+K I ++KD+ ++T ++K
Sbjct: 1004 ELKD----QLSEQTQKYSVSEE------EVKKNKQENDKLKKEIFTLQKDLRDKTVLIEK 1053
Query: 349 TKNHNEIIQTKLKEITEKTMSVEEKATNL----EDMLKEEEKDVKEVDVQLNLIKGVLFK 404
+ + K E+ ++ + +K T + E +++E K E+ NL++ K
Sbjct: 1054 SHEMERALSRKTDELNKQLKDLSQKYTEVKNVKEKLVEENAKQTSEILAVQNLLQ----K 1109
Query: 405 KAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERR 464
+ L+ +K++ IE + LK + +K K +++ +Q +
Sbjct: 1110 QHVPLEQVEALKKSLNGTIENLKEELKSMQRCYEKEQQTVTKLHQLLENQ---------K 1160
Query: 465 MSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSD 524
S + + + K+A E ++ ++ SL EK+ ++ N + + K S+ +
Sbjct: 1161 NSSVPLAEHLQIKEAFEKEVGIIKASLREKE----------EESQNKMEEVSKLQSEVQN 1210
Query: 525 EKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKR---TREMLHSKAEE 581
KQ+L K E +D S+ + K+ Q + + L L K E+LH+K +E
Sbjct: 1211 TKQAL--KKLETREVVDLSKYKATKSDLETQISSLNEKLANLNRKYEEVCEEVLHAKKKE 1268
Query: 582 VLSLEKRKQQLYTAME-------ERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSK 634
+ S + K+ L+ ++E ER ++ T L +I+ ++ E + E L+
Sbjct: 1269 I-SAKDEKELLHFSIEQEIKDQKERCDKSLTTITELQRRIQESAKQIEAKDNKITELLND 1327
Query: 635 IEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYA 694
+E+LK L+ + G K Q+ + + + L+++ A ++ +E+ A
Sbjct: 1328 VERLKQALNGLSQLTY-TSGNPTKRQSQLIDTLQHQVKSLEQQ----LADADRQHQEVIA 1382
Query: 695 LENT 698
+ T
Sbjct: 1383 IYRT 1386
Score = 57.8 bits (138), Expect = 5e-08
Identities = 108/480 (22%), Positives = 195/480 (40%), Gaps = 90/480 (18%)
Query: 19 VANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARER 78
V+ EE K + + KLK E +LQ +LR+ K V E K+ E
Sbjct: 1018 VSEEEVKKNKQENDKLKKEIFTLQKDLRD------------KTVLIE--------KSHEM 1057
Query: 79 ETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNW 138
E R L R DE L ++ + +K ++ +N
Sbjct: 1058 E------------RALSRKTDE---LNKQLKDLSQKYTEVKN------------------ 1084
Query: 139 DQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTE 198
E +EE+A + S+ L +Q Q+ + Q+E L N + L EL
Sbjct: 1085 ---VKEKLVEENAKQTSEILAVQNLLQKQHVPLE----QVEALKKSLNGTIENLKEELK- 1136
Query: 199 TISAQLELDKAAQDFRKIHNERQELIKQWENT----IEQMQKRDGDIDNCALELARIKQE 254
S Q +K Q K+H +L++ +N+ E +Q ++ + A ++++
Sbjct: 1137 --SMQRCYEKEQQTVTKLH----QLLENQKNSSVPLAEHLQIKEAFEKEVGIIKASLREK 1190
Query: 255 TREKENLVKEKIKFLESEIGNNTEFEKRISVAD-RKLLKCRTAYQDHETSRIQLKGELDS 313
E +N ++E K L+SE+ N + K++ + L K + D ET L +L +
Sbjct: 1191 EEESQNKMEEVSK-LQSEVQNTKQALKKLETREVVDLSKYKATKSDLETQISSLNEKLAN 1249
Query: 314 LKATVNRTSSD-LEALRKNIS-KIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVE 371
L + L A +K IS K +K++ + Q+ K+ E L ITE ++
Sbjct: 1250 LNRKYEEVCEEVLHAKKKEISAKDEKELLHFSIE-QEIKDQKERCDKSLTTITELQRRIQ 1308
Query: 372 EKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLK 431
E A +E ++ + E+ + +K L +Q T K I+ + +K
Sbjct: 1309 ESAKQIE----AKDNKITELLNDVERLKQALNGLSQLTYTSGNPTKRQSQLIDTLQHQVK 1364
Query: 432 HLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSL 491
L QL D + QE++ H+ +S +G ++ + ++AL +I+++R+ L
Sbjct: 1365 SLEQQLADAD---RQHQEVIAIYRTHL------LSAAQGHMDEDVQEAL-LQIIQMRQGL 1414
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 125 bits (313), Expect = 2e-28
Identities = 194/912 (21%), Positives = 394/912 (43%), Gaps = 117/912 (12%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETE 81
EE +LEDQ KL E+ L+D + E+ N+ +E ++SL K + +
Sbjct: 978 EEQIILEDQNCKLAKEKKLLEDRIAEFT----------TNLTEEEEKSKSLAKLKNK--- 1024
Query: 82 SEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQ 141
E + L R + + Q LE + +D + I + ++ LK Q+ ++
Sbjct: 1025 -HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEE 1083
Query: 142 ALEAWL----EESAHKDSDALTLQKY------AQQDDNKIRALTLQLERLTLECNQKRKI 191
L+A L EE+A K+ +++ Q+D RA + E+ + ++ +
Sbjct: 1084 ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEA 1143
Query: 192 LDNELTETI---SAQLEL-DKAAQDFRKIHNERQELIKQWENTIEQM-QKRDGDIDNCAL 246
L EL +T+ +AQ EL K Q+ + +E K E I++M QK ++ A
Sbjct: 1144 LKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAE 1203
Query: 247 ELARIKQETREKENLVKEKIKFLESEIG-----------NNTEFEKRISVADRKLLKCRT 295
+L +Q R K NL K K + LE+E G + E + + +L + +
Sbjct: 1204 QL---EQTKRVKANLEKAK-QTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV 1259
Query: 296 AYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEI 355
+ + E R +L ++ L+ ++ + L SK+ KD ++LQ T+ E+
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQ---EL 1316
Query: 356 IQTKLKE---ITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTE 412
+Q + ++ ++ K VE++ + + L+EEE+ ++ Q+ + Q
Sbjct: 1317 LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATL---------HAQVA 1367
Query: 413 TMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQ--QEIMYSQDFHIQQVERRMSRLKG 470
MK+K + + G + + + +LQK D E L Q +E + + D ++E+ +RL+
Sbjct: 1368 DMKKK--MEDSVGCLETAEEVKRKLQK-DLEGLSQRHEEKVAAYD----KLEKTKTRLQQ 1420
Query: 471 EINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLM 530
E++ +L L+ ++ + LE + KK L K +K ++E+
Sbjct: 1421 ELD------------DLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 531 TKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQ 590
+ E + L++A K +L + + E++ + V LEK K+
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKR 1528
Query: 591 QLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEK-LKNRYEILTVVM 649
A+E++ EE+K L +++ + + + + ++ E+ L+ R E
Sbjct: 1529 ----ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDE------ 1578
Query: 650 LPPEGEEEKTQAYYVIKAAQ-EKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNN 708
+ EE+K Q ++ + E E+ +++ A K E ++ LE ++S N N
Sbjct: 1579 ---QSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLE---AHIDSANKN 1632
Query: 709 YKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQR---QIRELQEDIQSME-NTLDVI 764
++ K++ +L+ Q+++ R +D+ ++ Q +E ++ ++SME + +
Sbjct: 1633 RDEAIKQLR------KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQ 1686
Query: 765 EHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQ 824
E LA + K +Q +L+ E K ++ +L I L++ +E
Sbjct: 1687 EELAAAERAKRQAQQERD-ELADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNT 1745
Query: 825 DIKLREMKQFHKVIDEMLVDI------IEENTEIRIILQTYFQQSGLELPTASTKGSRQS 878
++ +K+ + ID++ D+ ++N R L+ Q L++ +G+ +S
Sbjct: 1746 ELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQLER--QNKELKVKLQEMEGTVKS 1803
Query: 879 SRSPSHTSLSAR 890
S T+L A+
Sbjct: 1804 KYKASITALEAK 1815
Score = 115 bits (287), Expect = 3e-25
Identities = 142/795 (17%), Positives = 323/795 (40%), Gaps = 63/795 (7%)
Query: 38 RASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKAIAQRELGRV 97
+ +L++E + +E +I M +EL+ + E + KA ++ +
Sbjct: 1173 KKTLEEEAKTHEAQIQEMRQKHSQAVEELA----------EQLEQTKRVKANLEKAKQTL 1222
Query: 98 KDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDA 157
++E L NE+ +L+ K D E+ K +L L+ + N ++ ++ +
Sbjct: 1223 ENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVEL 1282
Query: 158 LTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIH 217
+ Q D+K LT L + +++L E + +S +L +++
Sbjct: 1283 DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKL-------KQVE 1335
Query: 218 NERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNT 277
+E+ EQ+++ + N ++A + + + + +++ + LE+
Sbjct: 1336 DEKNSFR-------EQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKR 1388
Query: 278 EFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKK 337
+ +K + ++ + AY E ++ +L+ ELD L ++ L K K +
Sbjct: 1389 KLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQ 1448
Query: 338 DIHEETARLQKTKNHNEIIQTKLKEITEKTMSVE---EKATNLEDMLKEEEKDVKEVDVQ 394
+ EE K + + + +E K +S+ E+A + L+ K +
Sbjct: 1449 LLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMED 1508
Query: 395 LNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQ 454
L K + K EL+ ++A+ ++E ++ L+ L +LQ + L+ + + +
Sbjct: 1509 LMSSKDDVGKSVHELEKS---KRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAM 1565
Query: 455 DFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYF 514
Q ER + + E + E+K+ L ++ E+ LE+++ + KKL DL
Sbjct: 1566 K---AQFERDLQG-RDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKD 1621
Query: 515 IKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREM 574
++ + + + ++ +L + +ELD + +++++ + + ++K
Sbjct: 1622 LEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAE 1681
Query: 575 LHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHK---TMLASQIRYVDQERENISTEFRER 631
+ EE+ + E+ K+Q +E +EI + + R ++ + E E
Sbjct: 1682 MIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELEEE 1741
Query: 632 LSKIEKLKNRYEI--LTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAE 689
E + +R + L + + + E++ A K +++L+R+ L K+ + E
Sbjct: 1742 QGNTELINDRLKKANLQIDQINTDLNLERSHAQ---KNENARQQLERQNKELKVKLQEME 1798
Query: 690 KEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKI-QLEEQKRAVDEKYRYKQRQIR 748
+ + YK S + E KI QLEEQ ++ + +Q+R
Sbjct: 1799 GTV-------------KSKYKASITAL-------EAKIAQLEEQLDNETKERQAACKQVR 1838
Query: 749 ELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTK 808
++ ++ + +D A K++ + QL ++ EE + + +R KL +
Sbjct: 1839 RTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQR 1898
Query: 809 EIRLLKDTKDETMEE 823
E+ +T D E
Sbjct: 1899 ELEDATETADAMNRE 1913
Score = 110 bits (274), Expect = 8e-24
Identities = 146/715 (20%), Positives = 322/715 (45%), Gaps = 80/715 (11%)
Query: 215 KIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIG 274
++ + +E++ + E ++ +K+ A E + ET + + L+ EK++ L+ ++
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQ------LAAENRLTEMETLQSQ-LMAEKLQ-LQEQLQ 890
Query: 275 NNTEFEKRISVADRKLLKCRTAYQDHETSRI--QLKGELDSLKATVNRTSSDLEALRKNI 332
TE A+ + L+ R + E I L+ ++ + ++ + +++NI
Sbjct: 891 AETEL-----CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNI 945
Query: 333 SKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVD 392
++++ + EE + QK + + KLK++ E+ + +E++ L K E + E
Sbjct: 946 QELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFT 1005
Query: 393 VQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMY 452
L + +K++ L K +A+++++E E L+++E
Sbjct: 1006 TNLTEEE----EKSKSLAKLKNKHEAMITDLE------------------ERLRREEKQR 1043
Query: 453 SQDFHIQQVERRMSRLKGEIN--SEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHN 510
Q++E+ +L+G+ S++ L+A+I EL+ L +K+ L+ + ++
Sbjct: 1044 ------QELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEE---LQAALARVE- 1093
Query: 511 DLYFIKKAHSKNSDEK--QSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEV 568
++A KN K + L ++I+EL ++ +KA+ K+DL E LK E+
Sbjct: 1094 -----EEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTEL 1148
Query: 569 KRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEF 628
+ T L S A + KR+Q++ + EE K H+ +QI+ + Q+ E
Sbjct: 1149 EDT---LDSTAAQQELRSKREQEVNILKKTLEEEAKTHE----AQIQEMRQKHSQAVEEL 1201
Query: 629 RERLSKIEKLKNRYEILTVVMLPPEGE---EEKTQAYYVIKAAQEKEELQREGDCLDAKI 685
E+L + +++K E + GE E K + ++++++ + L K
Sbjct: 1202 AEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKF 1261
Query: 686 NKAEK---EIYALENTLQV-LNSCNNNYKQSFKKVTPSSDEYE-LKIQLEEQKRAVDEKY 740
N+ E+ E+ LQV L++ QS K + + ++ L+ QL++ + + E+
Sbjct: 1262 NEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEEN 1321
Query: 741 RYK---QRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLE 797
R K ++++++++ S L+ E +N++++++ A + K+ E+ LE
Sbjct: 1322 RQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLE 1381
Query: 798 RVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRII-- 855
+ KL K++ L +E + D + + + +D++LVD+ + +
Sbjct: 1382 TAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEK 1441
Query: 856 LQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTSQSSIKVLELK 910
Q F Q E T S K + + R+ + AR + + S +++ + +E K
Sbjct: 1442 KQKKFDQLLAEEKTISAKYAEERDRAEA----EAREKETKALSLARALEEAMEQK 1492
Score = 91.3 bits (225), Expect = 4e-18
Identities = 160/778 (20%), Positives = 324/778 (41%), Gaps = 92/778 (11%)
Query: 148 EESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNEL-----TETISA 202
EE K+ + + +++ +N++ + +L E Q ++ L E E + A
Sbjct: 845 EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRA 904
Query: 203 QL-----ELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETRE 257
+L EL++ D E +E + + ++MQ+ +++ E +Q+ +
Sbjct: 905 RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQL 964
Query: 258 KENLVKEKIKFLESE----IGNNTEFEKRISVADRKLLKCRTA-YQDHETSRIQLKGELD 312
++ + K+K LE E N + K ++KLL+ R A + + T + L
Sbjct: 965 EKVTTEAKLKKLEEEQIILEDQNCKLAK-----EKKLLEDRIAEFTTNLTEEEEKSKSLA 1019
Query: 313 SLKATVNRTSSDLEALRKNISKIKKDIHEETARLQ-KTKNHNEIIQTKLKEITEKTMSVE 371
LK +DLE + K ++++ + +L+ + + ++ I +I E M +
Sbjct: 1020 KLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA 1079
Query: 372 EKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTR---- 427
+K L+ L E++ + ++ L I+ L + ELQ + E+A ++ E +
Sbjct: 1080 KKEEELQAALARVEEEAAQKNMALKKIR-ELESQISELQEDLESERASRNKAEKQKRDLG 1138
Query: 428 SSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAK---- 483
L+ L +L+ T QQE+ ++ Q+V L+ E + E Q E +
Sbjct: 1139 EELEALKTELEDTLDSTAAQQELRSKRE---QEVNILKKTLEEEAKTHEAQIQEMRQKHS 1195
Query: 484 --IVELRKSLEEKKSTCG-------LLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKIN 534
+ EL + LE+ K LE + +L N++ + + + +++ + ++
Sbjct: 1196 QAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQ 1255
Query: 535 ELNLFIDRSEK--------------ELDKAKGF------KQDLMIED-NLLKLEVKRTRE 573
EL + + E+ ELD G K + +D + L+ +++ T+E
Sbjct: 1256 ELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQE 1315
Query: 574 MLHSKAEEVLSLEKRKQQL---YTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRE 630
+L + + LSL + +Q+ + E+ EE + K L QI + + ++ + +
Sbjct: 1316 LLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMED 1375
Query: 631 RLSKIEKLKNRYEILTVVMLPPEG----EEEKTQAYYVIKAAQEKEELQREGDCLDAKIN 686
+ +E + E+ + EG EEK AY K + K LQ+E D L ++
Sbjct: 1376 SVGCLETAE---EVKRKLQKDLEGLSQRHEEKVAAY--DKLEKTKTRLQQELDDLLVDLD 1430
Query: 687 KAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQK-----RAVDEKYR 741
+ LE + + K K D E + + +E K RA++E
Sbjct: 1431 HQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAME 1490
Query: 742 YKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTK 801
K R ++ ME+ + + + +V E K+A L ++ EE K +LE +
Sbjct: 1491 QKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRA----LEQQVEEMKTQLEELED 1546
Query: 802 QC-----AKLTKEIRL--LKDTKDETMEEQDIKLRE-MKQFHKVIDEMLVDIIEENTE 851
+ AKL E+ L +K + ++ +D + E KQ + + EM ++ +E +
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ 1604
Score = 79.0 bits (193), Expect = 2e-14
Identities = 99/540 (18%), Positives = 218/540 (40%), Gaps = 63/540 (11%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
L+D L L +R S + L + +++ + + + K + + + + +A RE E++
Sbjct: 1422 LDDLLVDLDHQRQSACN-LEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALS 1480
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAW 146
A A E K E++RL + + +E ++ + K+ +L+ K + + ++
Sbjct: 1481 LARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQ 1540
Query: 147 LEE-------------------SAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQ 187
LEE A K LQ +Q + K + L Q+ + E
Sbjct: 1541 LEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELED 1600
Query: 188 KRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALE 247
+RK + +++L + R E IKQ QM+ ++D+
Sbjct: 1601 ERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRAS 1660
Query: 248 LARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQL 307
I + +E E +K+K +E+E+ + ++ ++ A+R A + + R +L
Sbjct: 1661 REEILAQAKENE----KKLKSMEAEM---IQLQEELAAAER-------AKRQAQQERDEL 1706
Query: 308 KGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKT 367
E+ + + L I+++++++ EE + + + ++ +I
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL 1766
Query: 368 MSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTR 427
A E+ ++ E+ KE+ V+L ++G T K KA ++ +E
Sbjct: 1767 NLERSHAQKNENARQQLERQNKELKVKLQEMEG----------TVKSKYKASITALEAKI 1816
Query: 428 SSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAK---- 483
+ L+ ++LD ET ++Q +++ E+++ + +++ E + A + K
Sbjct: 1817 AQLE------EQLDNETKERQAACKQ----VRRTEKKLKDVLLQVDDERRNAEQYKDQAD 1866
Query: 484 -----IVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNL 538
+ +L++ LEE + +KL +L + + E SL K+ +L
Sbjct: 1867 KASTRLKQLKRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLRRGDL 1926
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 124 bits (311), Expect = 4e-28
Identities = 174/867 (20%), Positives = 371/867 (42%), Gaps = 106/867 (12%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSI-TQSLCKARER-- 78
+E ++++ K+KDE A + + +E EE++ ++ +++ ++ + L A ER
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD 912
Query: 79 -----ETESEEHFKAIAQR--------------------ELGRVKDEIQRLENEMASILE 113
+ + E K + +R E +K +I LE +A + +
Sbjct: 913 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 972
Query: 114 KKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRA 173
+K EN + T+++ GL D+ + E+ A +++ TL Q +++K+
Sbjct: 973 EKHATENKVKNLTEEMAGL------DETIAKLTKEKKALQEAHQQTLDD-LQAEEDKVNT 1025
Query: 174 LTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQ 233
LT + ++ Q+ L+ L + +++L++A + QE I EN +
Sbjct: 1026 LT----KAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN---E 1078
Query: 234 MQKRDGDIDNCALELARIKQETREKENL---VKEKIKFLESEIGNNTEFEKRISVADRKL 290
Q+ D + E++ ++ + +++ L +++KIK L++ I E E+ I +
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI---EELEEEIEA--ERA 1133
Query: 291 LKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRK---NISKIKKDIHEETARLQ 347
+ + Q + SR +L+ + L+ TS+ +E +K K+++D+ E T +
Sbjct: 1134 SRAKAEKQRSDLSR-ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ-- 1190
Query: 348 KTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQ 407
H T K+ + + E+ NL+ + ++ EK+ E+ ++++ L +
Sbjct: 1191 ----HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID----DLASNVE 1242
Query: 408 ELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSR 467
+ + + +E S LK + Q+L + Q+ + ++ +
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 468 LKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQ 527
L ++ S KQA +I EL++ LEE+ L ++ +D +++ + + + K
Sbjct: 1303 LVSQL-SRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKA 1361
Query: 528 SLMTKINELNLFID--RSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSL 585
L +++ N + R++ E D + ++L L ++ E + + + SL
Sbjct: 1362 ELQRALSKANTEVAQWRTKYETDAIQR-TEELEEAKKKLAQRLQAAEEHVEAVNAKCASL 1420
Query: 586 EKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKL------- 638
EK KQ+L +E+ +++ A+ +D+++ N E K E+
Sbjct: 1421 EKTKQRLQNEVEDLMLDVERTNAACAA----LDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 639 -KNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALEN 697
K + T + EE +K +E + LQ+E L +I + K I+ LE
Sbjct: 1477 QKEARSLGTELFKIKNAYEESLDQLETLK--RENKNLQQEISDLTEQIAEGGKRIHELEK 1534
Query: 698 TLQVLNSCNNNYKQSFKKVTPSSDEYE---LKIQLE--EQKRAVDEKYRYKQRQIRELQE 752
+ + + + ++ S + E L+IQLE + K VD K K +I +L+
Sbjct: 1535 IKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Query: 753 D----IQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTK 808
+ ++SM++TLD E + N +L +K + + E + +L + A+ +
Sbjct: 1595 NHIRIVESMQSTLDA-EIRSRNDAIRLKKK------MEGDLNEMEIQLNHANRMAAEALR 1647
Query: 809 EIR----LLKDTK----DETMEEQDIK 827
R +LKDT+ D ++D+K
Sbjct: 1648 NYRNTQGILKDTQIHLDDALRSQEDLK 1674
Score = 118 bits (295), Expect = 3e-26
Identities = 178/950 (18%), Positives = 402/950 (42%), Gaps = 118/950 (12%)
Query: 22 EENKLLEDQLSKLKDERASLQ-------DELREYEERINSMTSHFKNVKQELSITQSLCK 74
EE L++ ++KL E+ +LQ D+L+ E+++N++T ++Q++ + +
Sbjct: 986 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1045
Query: 75 ARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKC 134
++ E K + +L ++ I +ENE + EK KE I K++
Sbjct: 1046 QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIE---- 1101
Query: 135 QMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKI---RALTLQLERLTLECNQKRKI 191
D+QAL L++ + LQ ++ + +I RA + E+ + +++ +
Sbjct: 1102 ----DEQALGIQLQKKIKE------LQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 192 LDNELTE---TISAQLELDKAAQ-DFRKIHNERQELIKQWENTIEQMQKRDGD------- 240
+ L E SAQ+E++K + +F+K+ + +E Q E T ++K+ D
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211
Query: 241 -IDNCALELARIKQETREKENLVKEKIKFLESEIGNNTE----FEKRISVADRKLLKCRT 295
IDN L R+KQ+ ++++ +K +I L S + ++ EK + +L + ++
Sbjct: 1212 QIDN----LQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 296 AYQDH--------------ETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHE 341
++ +T + +LD +A V++ S +A + I ++K+ + E
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE 1327
Query: 342 E-------TARLQKTKNHNEIIQTKLKEITEKTMSVE----EKATNLEDMLKEEEKDVKE 390
E LQ +++ ++++ + +E E ++ + T + + E D +
Sbjct: 1328 EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQ 1387
Query: 391 VDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEI 450
+L K K AQ LQ +AV ++ + + L ++++ L + +
Sbjct: 1388 RTEELEEAKK---KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAA 1444
Query: 451 MYSQDFHIQQVERRMSRLKG---------EINSEEKQALEAKIVELRKSLEEKKSTCGLL 501
+ D + ++ ++ K E + +E ++L ++ +++ + EE L
Sbjct: 1445 CAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETL 1504
Query: 502 ETQIKKLHNDLYFI--------KKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGF 553
+ + K L ++ + K+ H +KQ K EL ++ +E L+ +G
Sbjct: 1505 KRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC-ELQAALEEAEASLEHEEGK 1563
Query: 554 KQDLMIEDNLLKLEVKR-----TREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKT 608
+ +E N +K EV R E+ K + +E + L + R + I++ K
Sbjct: 1564 ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1623
Query: 609 MLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEG-----EEEKTQAYY 663
M +++ ++ R + +N IL + + E+ K Q
Sbjct: 1624 MEGD----LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAM 1679
Query: 664 VIKAAQ----EKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPS 719
V + A E EEL+ + + AE+E+ +Q+L++ N + + KK+
Sbjct: 1680 VERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1739
Query: 720 SDEYELKIQ-LEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEK 778
+ + +++ + ++ R +EK + + E+++ ++T +E + N+++ + +
Sbjct: 1740 ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1799
Query: 779 QAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVI 838
Q + E ++ L+ KQ KL +R L+ + + ++ +++ + +
Sbjct: 1800 QL------RLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRV 1853
Query: 839 DEMLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLS 888
E+ E+ I + LQ + L+ S K + + S+T+L+
Sbjct: 1854 KELTYQTEEDRKNI-LRLQDLVDK--LQAKVKSYKRQAEEAEEQSNTNLA 1900
Score = 100 bits (250), Expect = 5e-21
Identities = 133/627 (21%), Positives = 269/627 (42%), Gaps = 61/627 (9%)
Query: 265 KIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSD 324
K+ F + + E EK ++ + K + E R +L+ ++ +L N
Sbjct: 837 KLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQ 896
Query: 325 LEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEE-------KATNL 377
++A + ++ D E +L KTK ++ K+KE+TE+ EE K L
Sbjct: 897 VQAEAEGLA----DAEERCDQLIKTKIQ---LEAKIKEVTERAEDEEEINAELTAKKRKL 949
Query: 378 EDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQL 437
ED E +KD+ D++L L K K A E + + + E+ ++ ++ T + L L
Sbjct: 950 EDECSELKKDID--DLELTLAKVEKEKHATENKVKNLTEE--MAGLDETIAKLTKEKKAL 1005
Query: 438 QKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKST 497
Q+ +TL +Q E +++ L ++ K LE ++ +L SLE++K
Sbjct: 1006 QEAHQQTLDD----------LQAEEDKVNTL-----TKAKIKLEQQVDDLEGSLEQEKKL 1050
Query: 498 CGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDL 557
LE +KL DL +++ +EKQ L K+ + I + +++ + L
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQL 1110
Query: 558 MIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYV 617
+ L+ ++ E + ++ EK++ L +EE +E ++ ++QI +
Sbjct: 1111 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE-M 1169
Query: 618 DQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQRE 677
+++RE EF++ +E+ ++E + K A V + ++ + LQR
Sbjct: 1170 NKKRE---AEFQKMRRDLEEATLQHEATAATL-------RKKHADSVAELGEQIDNLQRV 1219
Query: 678 GDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVD 737
L+ + ++ + EI L + ++ ++ N ++ + T ELK + EEQ+R ++
Sbjct: 1220 KQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR--TLEDQLSELKSKEEEQQRLIN 1277
Query: 738 EKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLE 797
+ + R LQ + LD E L + + KQA++ Q+ EE K +LE
Sbjct: 1278 DLTAQRGR----LQTESGEFSRQLDEKEALVSQLSR---GKQAFTQQI----EELKRQLE 1326
Query: 798 RVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQ 857
K L ++ + D E+ + + + + + + ++ + T+ +
Sbjct: 1327 EEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTK----YE 1382
Query: 858 TYFQQSGLELPTASTKGSRQSSRSPSH 884
T Q EL A K +++ + H
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEH 1409
Score = 94.7 bits (234), Expect = 3e-19
Identities = 148/784 (18%), Positives = 316/784 (40%), Gaps = 93/784 (11%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
L +Q+ L+ + L+ E E + I+ + S+ + V + + +C+ E + +
Sbjct: 1209 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKE-------NGIFKATQKLDGLKCQMNWD 139
+ QR + + + RL+ E + +KE G TQ+++ LK Q+ +
Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328
Query: 140 QQALEAWLE--ESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELT 197
+A A +S+ D D L ++Y ++ ++K L L + E Q R + +
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLR-EQYEEEQESKAE-LQRALSKANTEVAQWRTKYETDAI 1386
Query: 198 ETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKR-DGDIDNCALELAR------ 250
+ E K + E E + ++E+ ++R ++++ L++ R
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACA 1446
Query: 251 -IKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKG 309
+ ++ R + ++ E + E +K +L K + AY++ LK
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKR 1506
Query: 310 ELDSLKATVNRTSSDLEALRKNI---SKIKKDIHEETARLQKTKNHNEIIQTKLKEITEK 366
E +L+ ++ + + K I KIKK + +E LQ E + L+ K
Sbjct: 1507 ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL---EEAEASLEHEEGK 1563
Query: 367 TMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKE---------- 416
+ ++ L + E ++ + E D +++ +K + + +Q+ E
Sbjct: 1564 ILRIQ---LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 417 -KAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSE 475
K + ++ L H N + Q I+ H+ R LK ++
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680
Query: 476 EKQA--LEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKI 533
E++A L+A+I ELR +LE+ + + + E ++ + + ++ + K+ L T I
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 534 NELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLY 593
+++ +G +D++ E + + K+ AEE+ +K+Q
Sbjct: 1741 SQM--------------QGEMEDILQEARNAEEKAKKAITDAAMMAEEL-----KKEQDT 1781
Query: 594 TAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPE 653
+A ER ++ + +T+ Q+R E E ++ + ++ +I+KL+ R V L E
Sbjct: 1782 SAHLERMKK-NMEQTVKDLQLRL--DEAEQLALKGGKK--QIQKLEAR-----VRELEGE 1831
Query: 654 GEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSF 713
E E+ + +K ++ E +E L + + K I L++ + L + +YK+
Sbjct: 1832 VESEQKRNAEAVKGLRKHERRVKE---LTYQTEEDRKNILRLQDLVDKLQAKVKSYKR-- 1886
Query: 714 KKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKE 773
Q +E+ + R+LQ +++ E D+ E N ++
Sbjct: 1887 ------------------QAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRV 1928
Query: 774 KLSE 777
K E
Sbjct: 1929 KSRE 1932
Score = 93.2 bits (230), Expect = 1e-18
Identities = 146/735 (19%), Positives = 300/735 (40%), Gaps = 90/735 (12%)
Query: 196 LTETISAQLELDKAAQDFRKIHNE---RQELIKQWENTIEQMQKRDGDIDNCALELARIK 252
L ++ + E+ ++F+KI +E + K+ E + + K D+ A
Sbjct: 845 LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904
Query: 253 QETREK-ENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGEL 311
+ E+ + L+K KI+ LE++I TE + + +L + +D + +LK ++
Sbjct: 905 ADAEERCDQLIKTKIQ-LEAKIKEVTERAEDEEEINAELTAKKRKLEDECS---ELKKDI 960
Query: 312 DSLKATVNRTSSDLEALR---KNISKIKKDIHEETARLQKTKN-----HNEII------Q 357
D L+ T+ + + A KN+++ + E A+L K K H + + +
Sbjct: 961 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE 1020
Query: 358 TKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEK 417
K+ +T+ + +E++ +LE L++E+K +++ ++G L K AQE + EK
Sbjct: 1021 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENEK 1079
Query: 418 AVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSE-- 475
L E LK ++ L + +Q + I++++ R+ L+ EI +E
Sbjct: 1080 QQLDE------KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERA 1133
Query: 476 -----EKQA--LEAKIVELRKSLEEKKSTCGL-------LETQIKKLHNDLYFIKKAHSK 521
EKQ L ++ E+ + LEE E + +K+ DL H
Sbjct: 1134 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1193
Query: 522 NSDE-KQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAE 580
+ ++ + EL +++D + KQ L E + +K+E+ + L S E
Sbjct: 1194 TAATLRKKHADSVAELG-------EQIDNLQRVKQKLEKEKSEMKMEI----DDLASNVE 1242
Query: 581 EVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKN 640
V + +++ +E++ E+K + I + +R + TE E ++++ +
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKE- 1301
Query: 641 RYEILTVVMLPPEGEEEKTQAYYVIKAAQEKE---------ELQREGDCLDAKINKAEKE 691
+V G++ TQ +K E+E LQ D + E+E
Sbjct: 1302 -----ALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356
Query: 692 IYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQ 751
+ + L+ N Q K +D + +LEE K+ + ++ + + + +
Sbjct: 1357 QESKAELQRALSKANTEVAQWRTKY--ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 752 EDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSK--------------ETEEQKPKLE 797
S+E T +++ ++ + A L K + EE +LE
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELE 1474
Query: 798 RVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRII-- 855
K+ L E+ +K+ +E++++ + RE K + I ++ I E I +
Sbjct: 1475 ASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1534
Query: 856 LQTYFQQSGLELPTA 870
++ +Q EL A
Sbjct: 1535 IKKQVEQEKCELQAA 1549
Score = 61.6 bits (148), Expect = 3e-09
Identities = 104/463 (22%), Positives = 185/463 (39%), Gaps = 108/463 (23%)
Query: 15 FAIPVANEENKLLEDQLSKLKDERASLQDELREYEE-------RINSMTSHFKNVKQELS 67
F I A EE+ DQL LK E +LQ E+ + E RI+ + K V+QE
Sbjct: 1488 FKIKNAYEESL---DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544
Query: 68 ITQSLCKARERETESEEHFKAIAQRELGRVKDEIQR------------------LENEMA 109
Q+ + E E EE Q EL +VK E+ R + M
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604
Query: 110 SILEKKSDKENGIFKATQKLDG----LKCQMNW-DQQALEAW---------LEESAHKDS 155
S L+ + N + +K++G ++ Q+N ++ A EA L+++
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664
Query: 156 DALTLQKYAQQDDNKI--RALTLQLE----RLTLECNQK-RKILDNEL------------ 196
DAL Q+ ++ + RA LQ E R TLE ++ RKI + EL
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724
Query: 197 -------------TETISAQLELDKAAQDFRKIHNERQELI------------------- 224
T+ Q E++ Q+ R + ++ I
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 225 -----KQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEF 279
K E T++ +Q R + + AL+ K++ ++ E V+E +ESE N E
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGG--KKQIQKLEARVRELEGEVESEQKRNAEA 1842
Query: 280 EKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRK----NISKI 335
K + +R++ + ++ + ++L+ +D L+A V E + N++K
Sbjct: 1843 VKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKF 1902
Query: 336 KKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLE 378
+K HE L++ + +I ++++ ++ K+ V K + E
Sbjct: 1903 RKLQHE----LEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 124 bits (311), Expect = 4e-28
Identities = 174/867 (20%), Positives = 371/867 (42%), Gaps = 106/867 (12%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSI-TQSLCKARER-- 78
+E ++++ K+KDE A + + +E EE++ ++ +++ ++ + L A ER
Sbjct: 853 KEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEERCD 912
Query: 79 -----ETESEEHFKAIAQR--------------------ELGRVKDEIQRLENEMASILE 113
+ + E K + +R E +K +I LE +A + +
Sbjct: 913 QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 972
Query: 114 KKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRA 173
+K EN + T+++ GL D+ + E+ A +++ TL Q +++K+
Sbjct: 973 EKHATENKVKNLTEEMAGL------DETIAKLTKEKKALQEAHQQTLDD-LQAEEDKVNT 1025
Query: 174 LTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQ 233
LT + ++ Q+ L+ L + +++L++A + QE I EN +
Sbjct: 1026 LT----KAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIEN---E 1078
Query: 234 MQKRDGDIDNCALELARIKQETREKENL---VKEKIKFLESEIGNNTEFEKRISVADRKL 290
Q+ D + E++ ++ + +++ L +++KIK L++ I E E+ I +
Sbjct: 1079 KQQLDEKLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARI---EELEEEIEA--ERA 1133
Query: 291 LKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRK---NISKIKKDIHEETARLQ 347
+ + Q + SR +L+ + L+ TS+ +E +K K+++D+ E T +
Sbjct: 1134 SRAKAEKQRSDLSR-ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQ-- 1190
Query: 348 KTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQ 407
H T K+ + + E+ NL+ + ++ EK+ E+ ++++ L +
Sbjct: 1191 ----HEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEID----DLASNVE 1242
Query: 408 ELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSR 467
+ + + +E S LK + Q+L + Q+ + ++ +
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEA 1302
Query: 468 LKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQ 527
L ++ S KQA +I EL++ LEE+ L ++ +D +++ + + + K
Sbjct: 1303 LVSQL-SRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEEQESKA 1361
Query: 528 SLMTKINELNLFID--RSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSL 585
L +++ N + R++ E D + ++L L ++ E + + + SL
Sbjct: 1362 ELQRALSKANTEVAQWRTKYETDAIQR-TEELEEAKKKLAQRLQAAEEHVEAVNAKCASL 1420
Query: 586 EKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKL------- 638
EK KQ+L +E+ +++ A+ +D+++ N E K E+
Sbjct: 1421 EKTKQRLQNEVEDLMLDVERTNAACAA----LDKKQRNFDKILAEWKQKCEETHAELEAS 1476
Query: 639 -KNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALEN 697
K + T + EE +K +E + LQ+E L +I + K I+ LE
Sbjct: 1477 QKEARSLGTELFKIKNAYEESLDQLETLK--RENKNLQQEISDLTEQIAEGGKRIHELEK 1534
Query: 698 TLQVLNSCNNNYKQSFKKVTPSSDEYE---LKIQLE--EQKRAVDEKYRYKQRQIRELQE 752
+ + + + ++ S + E L+IQLE + K VD K K +I +L+
Sbjct: 1535 IKKQVEQEKCELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKR 1594
Query: 753 D----IQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTK 808
+ ++SM++TLD E + N +L +K + + E + +L + A+ +
Sbjct: 1595 NHIRIVESMQSTLDA-EIRSRNDAIRLKKK------MEGDLNEMEIQLNHANRMAAEALR 1647
Query: 809 EIR----LLKDTK----DETMEEQDIK 827
R +LKDT+ D ++D+K
Sbjct: 1648 NYRNTQGILKDTQIHLDDALRSQEDLK 1674
Score = 118 bits (295), Expect = 3e-26
Identities = 178/950 (18%), Positives = 402/950 (42%), Gaps = 118/950 (12%)
Query: 22 EENKLLEDQLSKLKDERASLQ-------DELREYEERINSMTSHFKNVKQELSITQSLCK 74
EE L++ ++KL E+ +LQ D+L+ E+++N++T ++Q++ + +
Sbjct: 986 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1045
Query: 75 ARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKC 134
++ E K + +L ++ I +ENE + EK KE I K++
Sbjct: 1046 QEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIE---- 1101
Query: 135 QMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKI---RALTLQLERLTLECNQKRKI 191
D+QAL L++ + LQ ++ + +I RA + E+ + +++ +
Sbjct: 1102 ----DEQALGIQLQKKIKE------LQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1151
Query: 192 LDNELTE---TISAQLELDKAAQ-DFRKIHNERQELIKQWENTIEQMQKRDGD------- 240
+ L E SAQ+E++K + +F+K+ + +E Q E T ++K+ D
Sbjct: 1152 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGE 1211
Query: 241 -IDNCALELARIKQETREKENLVKEKIKFLESEIGNNTE----FEKRISVADRKLLKCRT 295
IDN L R+KQ+ ++++ +K +I L S + ++ EK + +L + ++
Sbjct: 1212 QIDN----LQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKS 1267
Query: 296 AYQDH--------------ETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHE 341
++ +T + +LD +A V++ S +A + I ++K+ + E
Sbjct: 1268 KEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEE 1327
Query: 342 E-------TARLQKTKNHNEIIQTKLKEITEKTMSVE----EKATNLEDMLKEEEKDVKE 390
E LQ +++ ++++ + +E E ++ + T + + E D +
Sbjct: 1328 EIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQ 1387
Query: 391 VDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEI 450
+L K K AQ LQ +AV ++ + + L ++++ L + +
Sbjct: 1388 RTEELEEAKK---KLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAA 1444
Query: 451 MYSQDFHIQQVERRMSRLKG---------EINSEEKQALEAKIVELRKSLEEKKSTCGLL 501
+ D + ++ ++ K E + +E ++L ++ +++ + EE L
Sbjct: 1445 CAALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETL 1504
Query: 502 ETQIKKLHNDLYFI--------KKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGF 553
+ + K L ++ + K+ H +KQ K EL ++ +E L+ +G
Sbjct: 1505 KRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC-ELQAALEEAEASLEHEEGK 1563
Query: 554 KQDLMIEDNLLKLEVKR-----TREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKT 608
+ +E N +K EV R E+ K + +E + L + R + I++ K
Sbjct: 1564 ILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKK 1623
Query: 609 MLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEG-----EEEKTQAYY 663
M +++ ++ R + +N IL + + E+ K Q
Sbjct: 1624 MEGD----LNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAM 1679
Query: 664 VIKAAQ----EKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPS 719
V + A E EEL+ + + AE+E+ +Q+L++ N + + KK+
Sbjct: 1680 VERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETD 1739
Query: 720 SDEYELKIQ-LEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEK 778
+ + +++ + ++ R +EK + + E+++ ++T +E + N+++ + +
Sbjct: 1740 ISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDL 1799
Query: 779 QAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVI 838
Q + E ++ L+ KQ KL +R L+ + + ++ +++ + +
Sbjct: 1800 QL------RLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNAEAVKGLRKHERRV 1853
Query: 839 DEMLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLS 888
E+ E+ I + LQ + L+ S K + + S+T+L+
Sbjct: 1854 KELTYQTEEDRKNI-LRLQDLVDK--LQAKVKSYKRQAEEAEEQSNTNLA 1900
Score = 100 bits (250), Expect = 5e-21
Identities = 133/627 (21%), Positives = 269/627 (42%), Gaps = 61/627 (9%)
Query: 265 KIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSD 324
K+ F + + E EK ++ + K + E R +L+ ++ +L N
Sbjct: 837 KLFFKIKPLLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQ 896
Query: 325 LEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEE-------KATNL 377
++A + ++ D E +L KTK ++ K+KE+TE+ EE K L
Sbjct: 897 VQAEAEGLA----DAEERCDQLIKTKIQ---LEAKIKEVTERAEDEEEINAELTAKKRKL 949
Query: 378 EDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQL 437
ED E +KD+ D++L L K K A E + + + E+ ++ ++ T + L L
Sbjct: 950 EDECSELKKDID--DLELTLAKVEKEKHATENKVKNLTEE--MAGLDETIAKLTKEKKAL 1005
Query: 438 QKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKST 497
Q+ +TL +Q E +++ L ++ K LE ++ +L SLE++K
Sbjct: 1006 QEAHQQTLDD----------LQAEEDKVNTL-----TKAKIKLEQQVDDLEGSLEQEKKL 1050
Query: 498 CGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDL 557
LE +KL DL +++ +EKQ L K+ + I + +++ + L
Sbjct: 1051 RMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLKKKEFEISNLQSKIEDEQALGIQL 1110
Query: 558 MIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYV 617
+ L+ ++ E + ++ EK++ L +EE +E ++ ++QI +
Sbjct: 1111 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE-M 1169
Query: 618 DQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQRE 677
+++RE EF++ +E+ ++E + K A V + ++ + LQR
Sbjct: 1170 NKKRE---AEFQKMRRDLEEATLQHEATAATL-------RKKHADSVAELGEQIDNLQRV 1219
Query: 678 GDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVD 737
L+ + ++ + EI L + ++ ++ N ++ + T ELK + EEQ+R ++
Sbjct: 1220 KQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCR--TLEDQLSELKSKEEEQQRLIN 1277
Query: 738 EKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLE 797
+ + R LQ + LD E L + + KQA++ Q+ EE K +LE
Sbjct: 1278 DLTAQRGR----LQTESGEFSRQLDEKEALVSQLSR---GKQAFTQQI----EELKRQLE 1326
Query: 798 RVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQ 857
K L ++ + D E+ + + + + + + ++ + T+ +
Sbjct: 1327 EEIKAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTK----YE 1382
Query: 858 TYFQQSGLELPTASTKGSRQSSRSPSH 884
T Q EL A K +++ + H
Sbjct: 1383 TDAIQRTEELEEAKKKLAQRLQAAEEH 1409
Score = 94.7 bits (234), Expect = 3e-19
Identities = 148/784 (18%), Positives = 316/784 (40%), Gaps = 93/784 (11%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
L +Q+ L+ + L+ E E + I+ + S+ + V + + +C+ E + +
Sbjct: 1209 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSK 1268
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKE-------NGIFKATQKLDGLKCQMNWD 139
+ QR + + + RL+ E + +KE G TQ+++ LK Q+ +
Sbjct: 1269 EEEQQRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEE 1328
Query: 140 QQALEAWLE--ESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELT 197
+A A +S+ D D L ++Y ++ ++K L L + E Q R + +
Sbjct: 1329 IKAKNALAHALQSSRHDCDLLR-EQYEEEQESKAE-LQRALSKANTEVAQWRTKYETDAI 1386
Query: 198 ETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKR-DGDIDNCALELAR------ 250
+ E K + E E + ++E+ ++R ++++ L++ R
Sbjct: 1387 QRTEELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACA 1446
Query: 251 -IKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKG 309
+ ++ R + ++ E + E +K +L K + AY++ LK
Sbjct: 1447 ALDKKQRNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLETLKR 1506
Query: 310 ELDSLKATVNRTSSDLEALRKNI---SKIKKDIHEETARLQKTKNHNEIIQTKLKEITEK 366
E +L+ ++ + + K I KIKK + +E LQ E + L+ K
Sbjct: 1507 ENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAAL---EEAEASLEHEEGK 1563
Query: 367 TMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKE---------- 416
+ ++ L + E ++ + E D +++ +K + + +Q+ E
Sbjct: 1564 ILRIQ---LELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRL 1620
Query: 417 -KAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSE 475
K + ++ L H N + Q I+ H+ R LK ++
Sbjct: 1621 KKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDLKEQLAMV 1680
Query: 476 EKQA--LEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKI 533
E++A L+A+I ELR +LE+ + + + E ++ + + ++ + K+ L T I
Sbjct: 1681 ERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDI 1740
Query: 534 NELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLY 593
+++ +G +D++ E + + K+ AEE+ +K+Q
Sbjct: 1741 SQM--------------QGEMEDILQEARNAEEKAKKAITDAAMMAEEL-----KKEQDT 1781
Query: 594 TAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPE 653
+A ER ++ + +T+ Q+R E E ++ + ++ +I+KL+ R V L E
Sbjct: 1782 SAHLERMKK-NMEQTVKDLQLRL--DEAEQLALKGGKK--QIQKLEAR-----VRELEGE 1831
Query: 654 GEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSF 713
E E+ + +K ++ E +E L + + K I L++ + L + +YK+
Sbjct: 1832 VESEQKRNAEAVKGLRKHERRVKE---LTYQTEEDRKNILRLQDLVDKLQAKVKSYKR-- 1886
Query: 714 KKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKE 773
Q +E+ + R+LQ +++ E D+ E N ++
Sbjct: 1887 ------------------QAEEAEEQSNTNLAKFRKLQHELEEAEERADIAESQVNKLRV 1928
Query: 774 KLSE 777
K E
Sbjct: 1929 KSRE 1932
Score = 93.2 bits (230), Expect = 1e-18
Identities = 146/735 (19%), Positives = 300/735 (40%), Gaps = 90/735 (12%)
Query: 196 LTETISAQLELDKAAQDFRKIHNE---RQELIKQWENTIEQMQKRDGDIDNCALELARIK 252
L ++ + E+ ++F+KI +E + K+ E + + K D+ A
Sbjct: 845 LLKSAETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGL 904
Query: 253 QETREK-ENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGEL 311
+ E+ + L+K KI+ LE++I TE + + +L + +D + +LK ++
Sbjct: 905 ADAEERCDQLIKTKIQ-LEAKIKEVTERAEDEEEINAELTAKKRKLEDECS---ELKKDI 960
Query: 312 DSLKATVNRTSSDLEALR---KNISKIKKDIHEETARLQKTKN-----HNEII------Q 357
D L+ T+ + + A KN+++ + E A+L K K H + + +
Sbjct: 961 DDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEE 1020
Query: 358 TKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEK 417
K+ +T+ + +E++ +LE L++E+K +++ ++G L K AQE + EK
Sbjct: 1021 DKVNTLTKAKIKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDL-KLAQESIMDIENEK 1079
Query: 418 AVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSE-- 475
L E LK ++ L + +Q + I++++ R+ L+ EI +E
Sbjct: 1080 QQLDE------KLKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERA 1133
Query: 476 -----EKQA--LEAKIVELRKSLEEKKSTCGL-------LETQIKKLHNDLYFIKKAHSK 521
EKQ L ++ E+ + LEE E + +K+ DL H
Sbjct: 1134 SRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1193
Query: 522 NSDE-KQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAE 580
+ ++ + EL +++D + KQ L E + +K+E+ + L S E
Sbjct: 1194 TAATLRKKHADSVAELG-------EQIDNLQRVKQKLEKEKSEMKMEI----DDLASNVE 1242
Query: 581 EVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKN 640
V + +++ +E++ E+K + I + +R + TE E ++++ +
Sbjct: 1243 TVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLTAQRGRLQTESGEFSRQLDEKE- 1301
Query: 641 RYEILTVVMLPPEGEEEKTQAYYVIKAAQEKE---------ELQREGDCLDAKINKAEKE 691
+V G++ TQ +K E+E LQ D + E+E
Sbjct: 1302 -----ALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQSSRHDCDLLREQYEEE 1356
Query: 692 IYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQ 751
+ + L+ N Q K +D + +LEE K+ + ++ + + + +
Sbjct: 1357 QESKAELQRALSKANTEVAQWRTKY--ETDAIQRTEELEEAKKKLAQRLQAAEEHVEAVN 1414
Query: 752 EDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSK--------------ETEEQKPKLE 797
S+E T +++ ++ + A L K + EE +LE
Sbjct: 1415 AKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELE 1474
Query: 798 RVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRII-- 855
K+ L E+ +K+ +E++++ + RE K + I ++ I E I +
Sbjct: 1475 ASQKEARSLGTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEK 1534
Query: 856 LQTYFQQSGLELPTA 870
++ +Q EL A
Sbjct: 1535 IKKQVEQEKCELQAA 1549
Score = 61.6 bits (148), Expect = 3e-09
Identities = 104/463 (22%), Positives = 185/463 (39%), Gaps = 108/463 (23%)
Query: 15 FAIPVANEENKLLEDQLSKLKDERASLQDELREYEE-------RINSMTSHFKNVKQELS 67
F I A EE+ DQL LK E +LQ E+ + E RI+ + K V+QE
Sbjct: 1488 FKIKNAYEESL---DQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKC 1544
Query: 68 ITQSLCKARERETESEEHFKAIAQRELGRVKDEIQR------------------LENEMA 109
Q+ + E E EE Q EL +VK E+ R + M
Sbjct: 1545 ELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQ 1604
Query: 110 SILEKKSDKENGIFKATQKLDG----LKCQMNW-DQQALEAW---------LEESAHKDS 155
S L+ + N + +K++G ++ Q+N ++ A EA L+++
Sbjct: 1605 STLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLD 1664
Query: 156 DALTLQKYAQQDDNKI--RALTLQLE----RLTLECNQK-RKILDNEL------------ 196
DAL Q+ ++ + RA LQ E R TLE ++ RKI + EL
Sbjct: 1665 DALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT 1724
Query: 197 -------------TETISAQLELDKAAQDFRKIHNERQELI------------------- 224
T+ Q E++ Q+ R + ++ I
Sbjct: 1725 QNTSLINTKKKLETDISQMQGEMEDILQEARNAEEKAKKAITDAAMMAEELKKEQDTSAH 1784
Query: 225 -----KQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEF 279
K E T++ +Q R + + AL+ K++ ++ E V+E +ESE N E
Sbjct: 1785 LERMKKNMEQTVKDLQLRLDEAEQLALKGG--KKQIQKLEARVRELEGEVESEQKRNAEA 1842
Query: 280 EKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRK----NISKI 335
K + +R++ + ++ + ++L+ +D L+A V E + N++K
Sbjct: 1843 VKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNTNLAKF 1902
Query: 336 KKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLE 378
+K HE L++ + +I ++++ ++ K+ V K + E
Sbjct: 1903 RKLQHE----LEEAEERADIAESQVNKLRVKSREVHTKVISEE 1941
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 124 bits (310), Expect = 5e-28
Identities = 183/858 (21%), Positives = 381/858 (44%), Gaps = 115/858 (13%)
Query: 23 ENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELS-ITQSLCK-ARERET 80
+ + LED+ S+LK + L+ L + E+ ++ + KN+ +ELS + +++ K RE++
Sbjct: 940 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKA 999
Query: 81 ESEEHFKAIAQRE--------LGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDG- 131
E H +A+ + L + K ++++ ++ S LE++ + + +KL+G
Sbjct: 1000 LQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGD 1059
Query: 132 LKC------QMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLEC 185
LK + D+Q L+ L++ KD + LQ + + + L LQ ++ E
Sbjct: 1060 LKLAQESILDLENDKQQLDERLKK---KDFEYCQLQSKVEDE----QTLGLQFQKKIKEL 1112
Query: 186 NQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQ----WENTIEQMQKRDGDI 241
+ + L+ E+ + + + +K D+ + E E +++ IE +KR+ +
Sbjct: 1113 QARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIELNKKREAEF 1172
Query: 242 DNCALELAR-IKQETREKENLV---KEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAY 297
L+L R +++ T + E +V ++K +E+G + +R+
Sbjct: 1173 ----LKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVK------------- 1215
Query: 298 QDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQ 357
Q E + + K E+D L SS +E++ K+ + ++K +L + + NE IQ
Sbjct: 1216 QKLEKEKSEFKLEIDDL-------SSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQ 1268
Query: 358 TKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEK 417
L E+T + ++ +A L L+E+E V ++ K+A QTE +K +
Sbjct: 1269 RSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRS---------KQAFTQQTEELKRQ 1319
Query: 418 AVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEK 477
L E +++L H Q + D + L++Q Y ++ Q+ + + R + NSE
Sbjct: 1320 --LEEENKAKNALAHA-LQSSRHDCDLLREQ---YEEE---QEGKAELQRALSKANSEVA 1370
Query: 478 Q---ALEAKIVELRKSLEEKKSTCGL----LETQIKKLHNDLYFIKKAHSKNSDEKQSLM 530
Q E ++ + LEE K E Q++ ++ ++K + E + LM
Sbjct: 1371 QWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLM 1430
Query: 531 TKI---NELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEK 587
+ N L +D+ ++ DK ++ E K + + ++ L + +E SL
Sbjct: 1431 VDVERANSLAAALDKKQRNFDK-------VLAE---WKTKCEESQAELEASLKESRSLST 1480
Query: 588 RKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRER---LSKIEKLKNRYEI 644
+L A EE ++++ K + + ++QE +++ + E + ++EK + + E+
Sbjct: 1481 ELFKLKNAYEEALDQLETVK----RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIEL 1536
Query: 645 LTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYAL----ENTLQ 700
+ E E + K + + EL + +D KI + ++EI L + T++
Sbjct: 1537 EKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVE 1596
Query: 701 VLNSCNNNYKQSFK-----KVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQ 755
+ S + +S K D E++IQL R E ++ +R +Q ++
Sbjct: 1597 TMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKH----LRSVQGQLK 1652
Query: 756 SMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKD 815
+ LD ++KE+L+ + + L E EE + LE+ T++ KL ++ L +
Sbjct: 1653 DTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ-TERARKLAEQELLDSN 1711
Query: 816 TKDETMEEQDIKLREMKQ 833
+ + + Q+ L K+
Sbjct: 1712 ERVQLLHTQNTSLIHTKK 1729
Score = 119 bits (299), Expect = 1e-26
Identities = 167/876 (19%), Positives = 377/876 (43%), Gaps = 131/876 (14%)
Query: 88 AIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWL 147
A ++E+ +K+E Q+ ++E+A K+ + E + Q+ + L+ Q+ + + L
Sbjct: 844 AETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENL---- 899
Query: 148 EESAHKDSDALTLQKY-----------AQQDDNKIRA-LTLQLERLTLECNQKRKILDNE 195
A + D L K+ +D+ +I A LT + +L EC++ +K +D+
Sbjct: 900 -LDAEERCDQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD- 957
Query: 196 LTETISAQLELDKAA----------------QDFRKIHNERQELIKQWENTIEQMQKRDG 239
E A++E +K A + K+ E++ L + + ++ +Q +
Sbjct: 958 -LELTLAKVEKEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEED 1016
Query: 240 DIDNCALELARIKQETREKENLVKEKIKF----------LESEI-----------GNNTE 278
+++ ++++Q+ + E+ ++++ K LE ++ + +
Sbjct: 1017 KVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQ 1076
Query: 279 FEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKK- 337
++R+ D + + ++ +D +T +Q + ++ L+A + ++EA R +K +K
Sbjct: 1077 LDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKELQARIEELEEEIEAERATRAKTEKQ 1136
Query: 338 ------DIHEETARLQK----TKNHNEIIQTKLKEITEKTMSVEEKATNLEDML----KE 383
++ E + RL++ T E+ + + E + +EE E M+ K+
Sbjct: 1137 RSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQHEAMVAALRKK 1196
Query: 384 EEKDVKEVDVQ---LNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQ-K 439
V E+ Q L +K L K+ E + E + + + ++++L+ + L+ +
Sbjct: 1197 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQ 1256
Query: 440 LDFETLKQQEIMYSQDFHIQQVERRMSRLK---GEIN-------------SEEKQALEAK 483
L K +EI S + ++ + SRL+ GE++ S KQA +
Sbjct: 1257 LSEARGKNEEIQRS----LSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQ 1312
Query: 484 IVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFID-- 541
EL++ LEE+ L ++ +D +++ + + + K L +++ N +
Sbjct: 1313 TEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1372
Query: 542 RSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTE 601
R++ E D + ++L L ++ + E + + + SLEK KQ+L +E+
Sbjct: 1373 RTKYETDAIQR-TEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMV 1431
Query: 602 EIKVHKTMLASQIRYVDQERENISTEFRERLSKIEK--------LKNRYEILTVVMLPPE 653
+++ ++ A+ +D+++ N E +K E+ LK + T +
Sbjct: 1432 DVERANSLAAA----LDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKN 1487
Query: 654 GEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSF 713
EE +K +E + L++E L +I + K I+ LE + + + + + +
Sbjct: 1488 AYEEALDQLETVK--RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLAL 1545
Query: 714 KKVTPSSDEYELKI-----QLEEQKRAVDEKYRYKQRQIREL----QEDIQSMENTLDVI 764
++ + + E KI +L + K +D K K +I +L Q +++M++ LD
Sbjct: 1546 EEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDA- 1604
Query: 765 EHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQ 824
E + N +L +K + + E + +L +Q A+ K +R ++ +T
Sbjct: 1605 EVRSRNEAIRLKKK------MEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHL 1658
Query: 825 DIKLR---EMKQFHKVIDEMLVDIIEENTEIRIILQ 857
D LR ++K+ +++ + E E+R L+
Sbjct: 1659 DDALRGQEDLKEQLAIVERRANLLQAEVEELRATLE 1694
Score = 99.8 bits (247), Expect = 1e-20
Identities = 145/751 (19%), Positives = 305/751 (40%), Gaps = 81/751 (10%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
L +Q+ L+ + L+ E E++ I+ ++S ++V + + + +C+ E +
Sbjct: 1204 LGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGK 1263
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKA-------TQKLDGLKCQMNWD 139
QR L + + RL+ E + + +KE+ + + TQ+ + LK Q+ +
Sbjct: 1264 NEEIQRSLSELTTQKSRLQTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEE 1323
Query: 140 QQALEAWLE--ESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELT 197
+A A +S+ D D L ++Y ++ + K L L + E Q R + +
Sbjct: 1324 NKAKNALAHALQSSRHDCDLLR-EQYEEEQEGKAE-LQRALSKANSEVAQWRTKYETDAI 1381
Query: 198 ETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKR-DGDIDNCALELARI----- 251
+ E K + E+ E + ++E+ ++R G++++ +++ R
Sbjct: 1382 QRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAA 1441
Query: 252 ---KQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLK 308
K++ + L + K K ES+ ++ S++ +L K + AY++ +K
Sbjct: 1442 ALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLST-ELFKLKNAYEEALDQLETVK 1500
Query: 309 GELDSLKATV----------NRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEI--- 355
E +L+ + +T +LE RK I K DI + H E
Sbjct: 1501 RENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKIL 1560
Query: 356 -IQTKLKEI-TEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTET 413
IQ +L ++ +E + EK +E + + ++ V+ + L+ + E
Sbjct: 1561 RIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALD----AEVRSRNEAIRLK 1616
Query: 414 MKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQ----DFHIQQVERRMSRLK 469
K + L+EIE L H N Q ETLK + Q H+ R LK
Sbjct: 1617 KKMEGDLNEIE---IQLSHANRQAA----ETLKHLRSVQGQLKDTQLHLDDALRGQEDLK 1669
Query: 470 GEINSEEKQA--LEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQ 527
++ E++A L+A++ ELR +LE+ + L E ++ + + + ++ K+
Sbjct: 1670 EQLAIVERRANLLQAEVEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKK 1729
Query: 528 SLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEK 587
L T + +L ++ + ++ A+ + + + ++ E+K+ ++ + + ++K
Sbjct: 1730 KLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQD----TSAHLERMKK 1785
Query: 588 RKQQLYTAMEERTEEI--------KVHKTMLASQIRYVDQERENISTEFRERLSKIEKLK 639
+Q ++ R +E K L ++IR ++ E E + E + + K +
Sbjct: 1786 NLEQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYE 1845
Query: 640 NRYEILTVVMLPPEGEEEKTQA-----------YYVIKAAQEKEELQREGDCLDAKINKA 688
R + LT + EE++ V ++ EE + + K KA
Sbjct: 1846 RRVKELTY-----QSEEDRKNVLRLQDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKA 1900
Query: 689 EKEIYALENTLQVLNSCNNNYKQSFKKVTPS 719
+ E+ E + S N + + T S
Sbjct: 1901 QHELEEAEERADIAESQVNKLRAKTRDFTSS 1931
Score = 95.9 bits (237), Expect = 2e-19
Identities = 144/684 (21%), Positives = 284/684 (41%), Gaps = 86/684 (12%)
Query: 265 KIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSD 324
K+ F + + E EK ++ + K + E R +L+ +L +L N
Sbjct: 832 KLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQ 891
Query: 325 LEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEE-------KATNL 377
++A +N+ D E +L K K ++ K+KE+TE+ EE K L
Sbjct: 892 VQAESENLL----DAEERCDQLIKAKFQ---LEAKIKEVTERAEDEEEINAELTAKKRKL 944
Query: 378 EDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQL 437
ED E +KD+ D++L L K K A E + + + E+ L L+ +
Sbjct: 945 EDECSELKKDID--DLELTLAKVEKEKHATENKVKNLTEE------------LSGLDETI 990
Query: 438 QKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKST 497
KL E QE +Q E +++ L ++ K LE ++ +L SLE++K
Sbjct: 991 AKLTREKKALQEAHQQALDDLQAEEDKVNSL-----NKTKSKLEQQVEDLESSLEQEKKL 1045
Query: 498 CGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDL 557
LE +KL DL +++ ++KQ L ++ + + + + +++ +
Sbjct: 1046 RVDLERNKRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQF 1105
Query: 558 MIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYV 617
+ L+ ++ E + ++ EK++ +EE +E ++ + ++QI +
Sbjct: 1106 QKKIKELQARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTSTQIE-L 1164
Query: 618 DQERENISTEFRERLSKIEKLKNRYEILTVVM-------LPPEGEEEKTQAYYVIKAAQE 670
+++RE EF + +E+ ++E + + + GE+ K +E
Sbjct: 1165 NKKRE---AEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKE 1221
Query: 671 KEELQREGDCLDAKINKA-------EKEIYALENTLQVLNSCNNNYKQSFKKVTP----- 718
K E + E D L + + EK LE+ L N ++S ++T
Sbjct: 1222 KSEFKLEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRL 1281
Query: 719 SSDEYELKIQLEEQKRAVDEKYRYKQ----------RQIRELQEDIQSMENTLDVIEHLA 768
++ EL QLEE++ V + R KQ RQ+ E + ++ + L H
Sbjct: 1282 QTEAGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSSRHDC 1341
Query: 769 NNVKEKLSEKQAYSFQLSK-------ETEEQKPKLE----RVTKQCAKLTKEIRLLKDTK 817
+ ++E+ E+Q +L + E + + K E + T++ + K++
Sbjct: 1342 DLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDS 1401
Query: 818 DETMEEQDIK---LREMKQ-FHKVIDEMLVDIIEENTEIRIILQTYFQQSGLELPTASTK 873
+E +E + K L + KQ +++++VD+ N+ + + +Q + A K
Sbjct: 1402 EEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDK---KQRNFDKVLAEWK 1458
Query: 874 GSRQSSRSPSHTSLSARSSRSTST 897
+ S++ SL + SRS ST
Sbjct: 1459 TKCEESQAELEASL--KESRSLST 1480
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 122 bits (305), Expect = 2e-27
Identities = 167/858 (19%), Positives = 360/858 (41%), Gaps = 111/858 (12%)
Query: 88 AIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWL 147
A ++E+ +K+E ++ + E+A K+ + E + Q+ + L+ Q+ + AL
Sbjct: 847 AETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADALADAE 906
Query: 148 EESAHKDSDALTLQKYAQ------QDDNKIRA-LTLQLERLTLECNQKRKILDNELTETI 200
E + L+ + +D+ +I A LT + +L EC++ +K +D+ E
Sbjct: 907 ERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDD--LELT 964
Query: 201 SAQLELDKAA----------------QDFRKIHNERQELIKQWENTIEQMQKRDGDIDNC 244
A++E +K A + K+ E++ L + + T++ +Q + ++
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTL 1024
Query: 245 ALELARIKQETREKENLVKEKIKF----------------LESEIGNNTEFEK-----RI 283
+++Q+ + E ++++ K L E +TE +K ++
Sbjct: 1025 TKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKL 1084
Query: 284 SVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKK---DIH 340
+ ++ + +D + IQL+ ++ L+A + ++EA R + +K +K D+
Sbjct: 1085 KKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLS 1144
Query: 341 EE---------------TARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEE 385
E +A+++ K Q +++ E T+ E A L +
Sbjct: 1145 RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSV 1204
Query: 386 KDVKEVDVQLNLIKGVLFKKAQELQTE----------TMKEKA----VLSEIEGTRSSLK 431
++ E L +K L K+ EL+ E K KA + +E S +K
Sbjct: 1205 AELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIK 1264
Query: 432 HLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSL 491
+ Q+L E Q+ ++++ + + ++ S KQA +I EL++ L
Sbjct: 1265 TKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQL-SRGKQAFTQQIEELKRQL 1323
Query: 492 EEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFID--RSEKELDK 549
EE+ L ++ +D +++ + + + K L +++ N + R++ E D
Sbjct: 1324 EEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDA 1383
Query: 550 AKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKT- 608
+ ++L L ++ E + + + SLEK KQ+L +E+ +++
Sbjct: 1384 IQR-TEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAA 1442
Query: 609 --MLASQIRYVDQERENISTEFRERLSKIE-KLKNRYEILTVVMLPPEGEEEKTQAYYVI 665
L + R D+ ++ E +++E K + T + EE +
Sbjct: 1443 CIALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETL 1502
Query: 666 KAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYE- 724
K +E + LQ+E L +I + K I+ LE + L+ + + S ++ S + E
Sbjct: 1503 K--RENKNLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEG 1560
Query: 725 --LKIQLE--EQKRAVDEKYRYKQRQIRELQED----IQSMENTLDVIEHLANNVKEKLS 776
L+IQLE + K +D K K ++ +L+ + ++SM++TLD E + N ++
Sbjct: 1561 KILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDA-EIRSRNDALRIK 1619
Query: 777 EKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIR----LLKDTK---DETMEEQDIKLR 829
+K + + E + +L +Q A+ + +R +LKDT+ D+ + QD
Sbjct: 1620 KK------MEGDLNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKE 1673
Query: 830 EMKQFHKVIDEMLVDIIE 847
++ + + M ++ E
Sbjct: 1674 QLAMVERRANLMQAEVEE 1691
Score = 117 bits (292), Expect = 7e-26
Identities = 164/907 (18%), Positives = 383/907 (42%), Gaps = 101/907 (11%)
Query: 22 EENKLLEDQLSKLKDERASLQ-------DELREYEERINSMTSHFKNVKQELSITQSLCK 74
EE L++ ++KL E+ +LQ D+L+ E+++N++T ++Q++ + +
Sbjct: 984 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTLTKAKTKLEQQVDDLEGSLE 1043
Query: 75 ARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKC 134
++ E K + +L ++ EN+ + EK KE + K++
Sbjct: 1044 QEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIE---- 1099
Query: 135 QMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKI---RALTLQLERLTLECNQKRKI 191
D+QAL L++ + LQ ++ + +I RA + E+ + +++ +
Sbjct: 1100 ----DEQALAIQLQKKIKE------LQARIEELEEEIEAERASRAKAEKQRSDLSRELEE 1149
Query: 192 LDNELTE---TISAQLELDKAAQ-DFRKIHNERQELIKQWENTIEQMQKRDGD----IDN 243
+ L E SAQ+E++K + +F+K+ + +E Q E T ++K+ D +
Sbjct: 1150 ISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALRKKHADSVAELGE 1209
Query: 244 CALELARIKQETREKENLVKEKIKFLESEIGN----NTEFEKRISVADRKLLKCRTAYQD 299
L R+KQ+ ++++ +K +I L S + FEK + +L + +T ++
Sbjct: 1210 QIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEE 1269
Query: 300 HE--------------TSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETA- 344
+ T + +LD A V++ S +A + I ++K+ + EET
Sbjct: 1270 QQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKA 1329
Query: 345 ------RLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQ-LNL 397
LQ ++ ++++ + +E E ++ + + + + +Q
Sbjct: 1330 KSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEE 1389
Query: 398 IKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFH 457
++ K AQ LQ +AV S+ + + L ++++ L + + + D
Sbjct: 1390 LEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKK 1449
Query: 458 IQQVERRMSRLKG---------EINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKL 508
+ ++ ++ K E + +E ++L ++ +++ + EE L+ + K L
Sbjct: 1450 QRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNL 1509
Query: 509 HNDLYFI--------KKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIE 560
++ + K H +KQ L + +EL ++ +E L+ +G + +E
Sbjct: 1510 QQEISDLTEQIAEGGKHIHELEKVKKQ-LDHEKSELQTSLEEAEASLEHEEGKILRIQLE 1568
Query: 561 DNLLKLEVKR-----TREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIR 615
N +K E+ R E+ K + +E + L + R + +++ K M
Sbjct: 1569 LNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGD--- 1625
Query: 616 YVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPE----GEEE-KTQAYYVIKAAQ- 669
+++ ++ R+ + L+N IL L + G+++ K Q V + A
Sbjct: 1626 -LNEMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANL 1684
Query: 670 ---EKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELK 726
E EEL+ + + AE+E+ +Q+L++ N + + KK+ + + +
Sbjct: 1685 MQAEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGE 1744
Query: 727 IQ-LEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQL 785
++ + ++ R +EK + + E+++ ++T +E + N+++ + + Q
Sbjct: 1745 MEDIVQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQL----- 1799
Query: 786 SKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDI 845
+ E ++ L+ KQ KL +R L+ + + ++ +++ + + E+
Sbjct: 1800 -RLDEAEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQT 1858
Query: 846 IEENTEI 852
E+ I
Sbjct: 1859 EEDRKNI 1865
Score = 109 bits (272), Expect = 1e-23
Identities = 128/588 (21%), Positives = 257/588 (43%), Gaps = 61/588 (10%)
Query: 265 KIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSD 324
K+ F + + E EK ++ + K + E R EL+ T+ + +D
Sbjct: 835 KLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKR----KELEEKMVTLMQEKND 890
Query: 325 LEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEE-------KATNL 377
L+ + + D E +L KTK ++ K+KE+TE+ EE K L
Sbjct: 891 LQLQVQAEADALADAEERCDQLIKTKIQ---LEAKIKEVTERAEDEEEINAELTAKKRKL 947
Query: 378 EDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQL 437
ED E +KD+ D++L L K K A E + + + E+ ++ ++ T + L L
Sbjct: 948 EDECSELKKDID--DLELTLAKVEKEKHATENKVKNLTEE--MAGLDETIAKLTKEKKAL 1003
Query: 438 QKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKST 497
Q+ +TL +Q E +++ L ++ K LE ++ +L SLE++K
Sbjct: 1004 QEAHQQTLDD----------LQMEEDKVNTL-----TKAKTKLEQQVDDLEGSLEQEKKL 1048
Query: 498 CGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDL 557
C LE +KL DL +++ ++KQ L K+ + + + +++ + L
Sbjct: 1049 CMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQL 1108
Query: 558 MIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYV 617
+ L+ ++ E + ++ EK++ L +EE +E ++ ++QI +
Sbjct: 1109 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE-M 1167
Query: 618 DQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQRE 677
+++RE EF++ +E+ ++E + K A V + ++ + LQR
Sbjct: 1168 NKKRE---AEFQKMRRDLEESTLQHEATAAAL-------RKKHADSVAELGEQIDSLQRV 1217
Query: 678 GDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVD 737
L+ + ++ + EI L + ++ ++ N+++ + T E+K + EEQ+R ++
Sbjct: 1218 KQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCR--TLEDQLSEIKTKEEEQQRLIN 1275
Query: 738 EKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLE 797
E K R E E + ++ ++ L+ KQA++ Q+ EE K +LE
Sbjct: 1276 ELSAQKARLHTESGEFSRQLDEKDAMVSQLSRG-------KQAFTQQI----EELKRQLE 1324
Query: 798 RVTKQCAKLTKEIRLLKD----TKDETMEEQDIKLREMKQFHKVIDEM 841
TK + L ++ + +++ EEQ+ K + K E+
Sbjct: 1325 EETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSEV 1372
Score = 100 bits (249), Expect = 6e-21
Identities = 142/710 (20%), Positives = 290/710 (40%), Gaps = 89/710 (12%)
Query: 198 ETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETRE 257
E + + E +K ++ K +R+EL E + MQ+++ E +
Sbjct: 852 EMANMKEEFEKTKEELAKTEAKRKELE---EKMVTLMQEKNDLQLQVQAEADALADAEER 908
Query: 258 KENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKAT 317
+ L+K KI+ LE++I TE + + +L + +D + +LK ++D L+ T
Sbjct: 909 CDQLIKTKIQ-LEAKIKEVTERAEDEEEINAELTAKKRKLEDECS---ELKKDIDDLELT 964
Query: 318 VNRTSSDLEALR---KNISKIKKDIHEETARLQKTKN-----HNEII------QTKLKEI 363
+ + + A KN+++ + E A+L K K H + + + K+ +
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQMEEDKVNTL 1024
Query: 364 TEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEI 423
T+ +E++ +LE L++E+K +++ ++G L K AQE +T +K L+E
Sbjct: 1025 TKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDL-KLAQESTMDTENDKQQLNE- 1082
Query: 424 EGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSE-------E 476
LK ++ L + +Q + I++++ R+ L+ EI +E E
Sbjct: 1083 -----KLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 477 KQA--LEAKIVELRKSLEEKKSTCGL-------LETQIKKLHNDLYFIKKAH-------- 519
KQ L ++ E+ + LEE E + +K+ DL H
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAALR 1197
Query: 520 SKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDL---MIEDNLLKLEVKRTREMLH 576
K++D L +I+ L + EKE + K DL M + K ++ L
Sbjct: 1198 KKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLE 1257
Query: 577 SKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIE 636
+ E+ + E+ +Q+L + + + + Q+ D +S + +IE
Sbjct: 1258 DQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIE 1317
Query: 637 KLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALE 696
+LK + E E + K+ + +++A+ +L RE + E+E A
Sbjct: 1318 ELKRQLE---------EETKAKSTLAHALQSARHDCDLLRE---------QYEEEQEAKA 1359
Query: 697 NTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQS 756
+ ++ N+ Q K +D + +LEE K+ + ++ + + + + S
Sbjct: 1360 ELQRGMSKANSEVAQWRTKY--ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCAS 1417
Query: 757 MENTLDVIEHLANNVKEKLSEKQAYSFQLSKET--------------EEQKPKLERVTKQ 802
+E T +++ ++ + A L K+ EE + +LE K+
Sbjct: 1418 LEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEASQKE 1477
Query: 803 CAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEI 852
L+ E+ +K+ +E+++ + RE K + I ++ I E I
Sbjct: 1478 SRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHI 1527
Score = 99.4 bits (246), Expect = 1e-20
Identities = 168/830 (20%), Positives = 323/830 (38%), Gaps = 143/830 (17%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
L +Q+ L+ + L+ E E + IN + S+ + V + + + +C+ E +
Sbjct: 1207 LGEQIDSLQRVKQKLEKEKSELKMEINDLASNMETVSKAKANFEKMCRTLEDQLS----- 1261
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAW 146
E+ ++E QRL NE+++ + + + + D + Q++ +QA
Sbjct: 1262 ------EIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQ 1315
Query: 147 LEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLEL 206
+EE L++ +++ L L+ +C+ R+ + E Q +
Sbjct: 1316 IEE----------LKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGM 1365
Query: 207 DKAAQDFRKIHNERQELIKQWENTIE-QMQKRDGDIDNCALELARIKQETREKENLVKEK 265
KA + + QW E +R +++ +LA+ Q+ E V K
Sbjct: 1366 SKANSE-----------VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSK 1414
Query: 266 IKFLESEIGN-NTEFEKRISVADRKLLKCRTA---YQDHETSRIQLKGELDSLKATVNRT 321
LE E E + +R C ++ + + K + + +A + +
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQAELEAS 1474
Query: 322 SSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDML 381
+ +L + K+K E L+ K N+ +Q ++ ++TE+ +
Sbjct: 1475 QKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQ--------------I 1520
Query: 382 KEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLK-HLNHQLQKL 440
E K + E L +K L + ELQT + +A L EG ++ LN ++
Sbjct: 1521 AEGGKHIHE----LEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEI 1576
Query: 441 DFETL-KQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCG 499
D + K +E+ + H++ VE S L EI S AL K KK
Sbjct: 1577 DRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRS-RNDALRIK----------KKMEGD 1625
Query: 500 LLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMI 559
L E +I+ H + + +N Q + + + L +D + + D K +Q M+
Sbjct: 1626 LNEMEIQLNHANRQAAEAL--RNLRNTQGI---LKDTQLHLDDAIRGQDDLK--EQLAMV 1678
Query: 560 E--DNLLKLEVKRTREMLH-------SKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTML 610
E NL++ EV+ R L +E+L +R Q L+T + T I K L
Sbjct: 1679 ERRANLMQAEVEELRASLERTERGRKMAEQELLDASERVQLLHT---QNTSLINT-KKKL 1734
Query: 611 ASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQE 670
+ I + E E+I E R K +K + AA
Sbjct: 1735 ETDISQIQGEMEDIVQEARNAEEKAKKA-------------------------ITDAAMM 1769
Query: 671 KEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLE 730
EEL++E D T L N +Q+ K + DE E ++ L+
Sbjct: 1770 AEELKKEQD------------------TSAHLERMKKNMEQTVKDLQLRLDEAE-QLALK 1810
Query: 731 EQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETE 790
K+ + + + ++REL+ +++S + +H VK L + + +L+ +TE
Sbjct: 1811 GGKKQIQK----LEARVRELESEVESEQ------KHNVEAVK-GLRKHERRVKELTYQTE 1859
Query: 791 EQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDE 840
E + + R+ KL +++ K +E E+ ++ L + ++ ++E
Sbjct: 1860 EDRKNILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEE 1909
Score = 65.1 bits (157), Expect = 3e-10
Identities = 97/519 (18%), Positives = 210/519 (40%), Gaps = 104/519 (20%)
Query: 30 QLSKLKDERASLQDELREYEERINSMTSHFKNVKQE-LSITQSLCKARERETESEEHFKA 88
+L + E SL EL + + H + +K+E ++ Q + E+ E +H
Sbjct: 1470 ELEASQKESRSLSTELFKVKNAYEESLDHLETLKRENKNLQQEISDLTEQIAEGGKHI-- 1527
Query: 89 IAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLE 148
EL +VK ++ +KS+ + + +A L+
Sbjct: 1528 ---HELEKVKKQLDH----------EKSELQTSLEEAEASLE------------------ 1556
Query: 149 ESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDK 208
H++ L R+ LE NQ + +D ++ E ELD+
Sbjct: 1557 ---HEEGKIL---------------------RIQLELNQVKSEIDRKIAE---KDEELDQ 1589
Query: 209 AAQDFRKIHNERQEL----IKQWENTIEQMQKRDGDIDNCALEL-------ARIKQETRE 257
++ ++ Q I+ + + +K +GD++ ++L A + R
Sbjct: 1590 LKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNLRN 1649
Query: 258 KENLVKEKIKFLESEIGNNTEFEKRISVADRK-------LLKCRTAYQDHETSRIQLKGE 310
+ ++K+ L+ I + ++++++ +R+ + + R + + E R + E
Sbjct: 1650 TQGILKDTQLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTERGRKMAEQE 1709
Query: 311 LDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKE-ITEKTMS 369
L V + +L K++ DI + ++ + K K+ IT+ M
Sbjct: 1710 LLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDAAMM 1769
Query: 370 VEE------KATNLEDMLKEEEKDVKEVDVQLNLIKGVLFK-----------KAQELQTE 412
EE + +LE M K E+ VK++ ++L+ + + K + +EL++E
Sbjct: 1770 AEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVRELESE 1829
Query: 413 TMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLK-QQEIMYSQDFHIQQVERRMSRLKGE 471
E+ +E + KH ++++L ++T + ++ I+ QD + +++ ++ K +
Sbjct: 1830 VESEQK--HNVEAVKGLRKH-ERRVKELTYQTEEDRKNILRLQDL-VDKLQTKVKAYKRQ 1885
Query: 472 INSEEKQALE--AKIVELRKSLEEKKSTCGLLETQIKKL 508
E+Q+ AK +L+ LEE K + E+Q+ KL
Sbjct: 1886 AEEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKL 1924
Score = 34.3 bits (77), Expect = 0.56
Identities = 38/205 (18%), Positives = 93/205 (45%), Gaps = 27/205 (13%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETE 81
+E + E++ K + A + +EL++ ++ ++H + +K+ + Q++ + R E
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERMKKNME--QTVKDLQLRLDE 1803
Query: 82 SEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQ 141
+E+ ++++ +++ ++ LE+E+ S + + G+ K +++ L Q D++
Sbjct: 1804 AEQLALKGGKKQIQKLEARVRELESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRK 1863
Query: 142 ALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECN---QKRKILDNELTE 198
+ L LQ + K++A Q E + N K + L +EL E
Sbjct: 1864 --------------NILRLQDLVDKLQTKVKAYKRQAEEAEEQSNVNLAKFRKLQHELEE 1909
Query: 199 TIS----AQLELDKAAQDFRKIHNE 219
A+ +++K R++H +
Sbjct: 1910 AKERADIAESQVNKLRVKSREVHTK 1934
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 120 bits (300), Expect = 8e-27
Identities = 177/945 (18%), Positives = 401/945 (42%), Gaps = 108/945 (11%)
Query: 22 EENKLLEDQLSKLKDERASLQ-------DELREYEERINSMTSHFKNVKQELSITQSLCK 74
EE L++ ++KL E+ +LQ D+L+ E+++NS++ ++Q++ + +
Sbjct: 982 EEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLE 1041
Query: 75 ARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKC 134
++ E K + +L ++ I LEN+ + EK KE I + K++
Sbjct: 1042 QEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIE---- 1097
Query: 135 QMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDN 194
D+Q L L++ ++ + + + + RA ++E+L + +++ + +
Sbjct: 1098 ----DEQVLALQLQKKLKENQARIEELEEELEAERTARA---KVEKLRSDLSRELEEISE 1150
Query: 195 ELTE---TISAQLELDKAAQ-DFRKIHNERQELIKQWENTIEQMQKRDGD--------ID 242
L E S Q+E++K + +F+K+ + +E Q E T ++K+ D ID
Sbjct: 1151 RLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQID 1210
Query: 243 NCALELARIKQE---------------TREKENLVKEKI---KFLESEIGNNTEFEKRIS 284
N L R+KQ+ T E ++K K K + E+ ++
Sbjct: 1211 N----LQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLE 1266
Query: 285 VADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEE-- 342
A R L T +T +L +L+ +A +++ + + + + +K+ + EE
Sbjct: 1267 EAQRSLNDFTTQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGK 1326
Query: 343 -----TARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKE----EEKDVKEVDV 393
LQ ++ ++++ + +E TE ++ + + + E D +
Sbjct: 1327 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTE 1386
Query: 394 QLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKH----LNHQLQKLDFETLKQQE 449
+L K L ++ Q+ + A S +E T+ L++ L +++ + +
Sbjct: 1387 ELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDK 1446
Query: 450 IMYSQDFHIQQVERRMSRLKGEINSEEKQA--LEAKIVELRKSLEEKKSTCGLLETQIKK 507
+ D + + +++ + E+ S +K+A L ++ +L+ + EE + + K
Sbjct: 1447 KQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKN 1506
Query: 508 LHNDLYFI--------KKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMI 559
L ++ + K H KQ + K+ EL ++ +E L+ +G +
Sbjct: 1507 LQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKL-ELQSALEEAEASLEHEEGKILRAQL 1565
Query: 560 EDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAME--------ERTEEIKVHKTMLA 611
E N +K E++R L K EE+ ++ Q++ +++ R E ++V K M
Sbjct: 1566 EFNQIKAEIER---KLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEG 1622
Query: 612 --SQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIK--- 666
+++ ++ E ++++ ++ L +I + + ++ A +
Sbjct: 1623 DLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNL 1682
Query: 667 AAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELK 726
E EEL+ + + AE+E+ +Q+L+S N + KK+ SD +L+
Sbjct: 1683 LQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKM--ESDLTQLQ 1740
Query: 727 IQLEE---QKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSF 783
++EE + R +EK + + E+++ ++T +E + N+++ + + Q
Sbjct: 1741 SEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTIKDLQ---- 1796
Query: 784 QLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLV 843
+ E ++ L+ KQ KL +R L+ + + ++ M++ + I E+
Sbjct: 1797 --HRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTY 1854
Query: 844 DIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLS 888
EE+ + + LQ + L+L + K + + ++T+LS
Sbjct: 1855 Q-TEEDKKNLLRLQDLVDK--LQLKVKAYKRQAEEAEEQANTNLS 1896
Score = 111 bits (277), Expect = 4e-24
Identities = 160/834 (19%), Positives = 345/834 (41%), Gaps = 122/834 (14%)
Query: 76 RERETESEEHFKAIAQRELGRVKDEIQR-------LENEMASILEKKSDKENGIFKATQK 128
+ ETE E A + E GR+K+ +++ LE +M S+L++K+D + + +A Q
Sbjct: 843 KSAETEKE---MATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQV-QAEQD 898
Query: 129 LDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQK 188
+N ++ + ++ ++ + + + ++ LT + +L EC++
Sbjct: 899 ------NLNDAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSEL 952
Query: 189 RKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALEL 248
+K +D+ E A++E +K A EN ++ + + +D +L
Sbjct: 953 KKDIDD--LELTLAKVEKEKHAT----------------ENKVKNLTEEMAGLDEIIAKL 994
Query: 249 ARIKQETREKENLVKEKIKFLESEIGN----NTEFEKRISVADRKLLKCRTAYQDHETSR 304
+ K+ +E + ++ E ++ + + E+++ + L + + D E ++
Sbjct: 995 TKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAK 1054
Query: 305 IQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETAR----------LQKTKNHNE 354
+L+G+L + ++ +D L + + K + DI+++ ++ LQK N+
Sbjct: 1055 RKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLKENQ 1114
Query: 355 IIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKE----------VDVQLNLIKGVLFK 404
+L+E E + K L L E +++ E V +++N + F+
Sbjct: 1115 ARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQ 1174
Query: 405 K-AQELQTETMKEKAVLSEIEGTRS-SLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVE 462
K ++L+ T++ +A + + + S+ L Q+ L K ++ + V
Sbjct: 1175 KMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVT 1234
Query: 463 RRMSR-LKGEINSEE-KQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHS 520
M + +K + N E+ + LE + E R LEE + + TQ KL + +
Sbjct: 1235 SNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTE----NGELA 1290
Query: 521 KNSDEKQSLMTKINELNLF-------IDRSEKELDKAKG----------FKQDLMIEDNL 563
+ +EK++L++++ L + R +E KAK DL+ E
Sbjct: 1291 RQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQYE 1350
Query: 564 LKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQEREN 623
+ E K + + SKA ++ + K + T +RTEE++ K LA +++ ++ E
Sbjct: 1351 EETEAKAELQRVLSKANSEVAQWRTKYE--TDAIQRTEELEEAKKKLAQRLQDAEEAVEA 1408
Query: 624 ISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDA 683
++ + S +EK K+R L E E+ AA ++ QR D
Sbjct: 1409 VNA----KCSSLEKTKHR--------LQNEIEDLMVDVERSNAAAAALDKKQRNFD---- 1452
Query: 684 KINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDE-YELKIQLEEQKRAVDEKYRY 742
++L Y++S ++ S E L +L + K A +E +
Sbjct: 1453 ----------------KILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEH 1496
Query: 743 KQ---RQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERV 799
+ R+ + LQE+I + L + +++ + + +L EE + LE
Sbjct: 1497 LETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHE 1556
Query: 800 TKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIR 853
+ + E +K + + E+D ++ + K+ H+ + + L ++ T R
Sbjct: 1557 EGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSR 1610
Score = 89.7 bits (221), Expect = 1e-17
Identities = 125/701 (17%), Positives = 287/701 (40%), Gaps = 56/701 (7%)
Query: 206 LDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEK 265
L+K+ +++ + L+++ + Q+Q ++++ ++ + + E VKE
Sbjct: 865 LEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDAEERCDQLIKNKIQLEAKVKEM 924
Query: 266 IKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDL 325
+ LE E N E + + + + + D E + +++ E + + V + ++
Sbjct: 925 NERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEM 984
Query: 326 EALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEE 385
L + I+K+ K+ Q+ + ++ + K+ +++ + +E++ +LE L++E+
Sbjct: 985 AGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEK 1044
Query: 386 KDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSE-IEGTRSSLKHLNHQLQKLDFET 444
K +++ ++G L K QE + +K L E ++ + N +++
Sbjct: 1045 KVRMDLERAKRKLEGDL-KLTQESIMDLENDKLQLEEKLKKKEFDINQQNSKIEDEQVLA 1103
Query: 445 LKQQEIMYSQDFHIQQVERRMSRLKGEINSEEK--QALEAKIVELRKSLEEKKSTCGL-- 500
L+ Q+ + I+++E + + EK L ++ E+ + LEE +
Sbjct: 1104 LQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQI 1163
Query: 501 -----LETQIKKLHNDLYFIKKAHSKNSDE-KQSLMTKINELNLFIDRSEKELDKAKGFK 554
E + +K+ DL H + ++ + EL +++D + K
Sbjct: 1164 EMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELG-------EQIDNLQRVK 1216
Query: 555 QDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQI 614
Q L E + KLE+ + + S E+++ + +++ +E++ E +V +
Sbjct: 1217 QKLEKEKSEFKLEL----DDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSL 1272
Query: 615 RYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKE-- 672
+R + TE E ++E+ + LT G+ TQ +K E+E
Sbjct: 1273 NDFTTQRAKLQTENGELARQLEEKEALISQLT------RGKLSYTQQMEDLKRQLEEEGK 1326
Query: 673 -------ELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYEL 725
LQ D + E+E A +VL+ N+ Q K +D +
Sbjct: 1327 AKNALAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKY--ETDAIQR 1384
Query: 726 KIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQL 785
+LEE K+ + ++ + + + + S+E T +++ ++ + A + L
Sbjct: 1385 TEELEEAKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAAL 1444
Query: 786 SKET--------------EEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREM 831
K+ EE + +LE K+ L+ E+ LK+ +E++E + RE
Sbjct: 1445 DKKQRNFDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKREN 1504
Query: 832 KQFHKVIDEMLVDIIEENTEIRII--LQTYFQQSGLELPTA 870
K + I ++ + E + + ++ + LEL +A
Sbjct: 1505 KNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSA 1545
Score = 77.4 bits (189), Expect = 6e-14
Identities = 108/564 (19%), Positives = 242/564 (42%), Gaps = 115/564 (20%)
Query: 16 AIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKA 75
A +++ + + L++ K + Q EL + K+ S++ L K
Sbjct: 1440 AAAALDKKQRNFDKILAEWKQKYEESQSELESSQ-------------KEARSLSTELFKL 1486
Query: 76 RERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQ 135
+ ES EH + +RE +++EI L ++ E G K +L+ ++ Q
Sbjct: 1487 KNAYEESLEHLETF-KRENKNLQEEISDLTEQLG---------EGG--KNVHELEKVRKQ 1534
Query: 136 MNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNE 195
+ ++ L++ LEE+ + + ++ KI R LE NQ + ++ +
Sbjct: 1535 LEVEKLELQSALEEA----------EASLEHEEGKIL-------RAQLEFNQIKAEIERK 1577
Query: 196 LTETISAQLELDKAAQDFRKIHNERQELI----KQWENTIEQMQKRDGDIDNCALEL--- 248
L E E+++A ++ +++ + Q + + + +K +GD++ ++L
Sbjct: 1578 LAE---KDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHA 1634
Query: 249 ----ARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSR 304
A +++ + ++L+K+ L+ + N + ++ I++ +R+
Sbjct: 1635 NRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERR--------------N 1680
Query: 305 IQLKGELDSLKATVNRTSSDLEALRKNISKIKKDI---HEETARL--QKTKNHNEI--IQ 357
L+ EL+ L+A V +T + + + + + + H + L QK K +++ +Q
Sbjct: 1681 NLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQ 1740
Query: 358 TKLKEITEKTMSVEEKATN-LEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKE 416
++++E ++ + EEKA + D E+ KE D +L E MK+
Sbjct: 1741 SEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHL--------------ERMKK 1786
Query: 417 KAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEE 476
+E T L+H + +++ + K+Q +Q++E R+ L+GE+ +E+
Sbjct: 1787 -----NMEQTIKDLQHRLDEAEQIALKGGKKQ---------LQKLEARVRELEGELEAEQ 1832
Query: 477 KQALEA---------KIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQ 527
K+ E+ +I EL EE K L+ + KL + K+ + ++
Sbjct: 1833 KRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQAN 1892
Query: 528 SLMTKINELNLFIDRSEKELDKAK 551
+ ++K ++ +D +E+ D A+
Sbjct: 1893 TNLSKFRKVQHELDEAEERADIAE 1916
Score = 75.5 bits (184), Expect = 2e-13
Identities = 102/524 (19%), Positives = 230/524 (43%), Gaps = 88/524 (16%)
Query: 46 REYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLE 105
++YEE + + S K + S++ L K + ES EH + K E + L+
Sbjct: 1460 QKYEESQSELESSQKEAR---SLSTELFKLKNAYEESLEHLETF--------KRENKNLQ 1508
Query: 106 NEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQ 165
E++ + E+ E G K +L+ ++ Q+ ++ L++ LEE+ + +
Sbjct: 1509 EEISDLTEQLG--EGG--KNVHELEKVRKQLEVEKLELQSALEEA----------EASLE 1554
Query: 166 QDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELI- 224
++ KI R LE NQ + ++ +L E E+++A ++ +++ + Q +
Sbjct: 1555 HEEGKIL-------RAQLEFNQIKAEIERKLAEKDE---EMEQAKRNHQRVVDSLQTSLD 1604
Query: 225 ---KQWENTIEQMQKRDGDIDNCALEL-------ARIKQETREKENLVKEKIKFLESEIG 274
+ + +K +GD++ ++L A +++ + ++L+K+ L+ +
Sbjct: 1605 AETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVR 1664
Query: 275 NNTEFEKRISVADRK-------LLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEA 327
N + ++ I++ +R+ L + R + E SR + EL V S +
Sbjct: 1665 ANDDLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTS 1724
Query: 328 LRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKE-ITEKTMSVEE------KATNLEDM 380
L K++ D+ + + +++ + K K+ IT+ M EE + +LE M
Sbjct: 1725 LINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERM 1784
Query: 381 LKEEEKDVKEVDVQLNLIKGVLFK-----------KAQELQTETMKEKAVLSE-IEGTRS 428
K E+ +K++ +L+ + + K + +EL+ E E+ +E ++G R
Sbjct: 1785 KKNMEQTIKDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRK 1844
Query: 429 S---LKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIV 485
S +K L +Q ++ L+ Q+++ ++ +R+ + + N+ +K
Sbjct: 1845 SERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNL-----SKFR 1899
Query: 486 ELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSL 529
+++ L+E + + E+Q+ KL +A S++ KQ +
Sbjct: 1900 KVQHELDEAEERADIAESQVNKL--------RAKSRDIGAKQKM 1935
Score = 64.7 bits (156), Expect = 4e-10
Identities = 91/436 (20%), Positives = 186/436 (42%), Gaps = 82/436 (18%)
Query: 29 DQLSKLKDERASLQDELREYEERINS---MTSHFKNVKQELSIT----QSLCKARERETE 81
+ L K E +LQ+E+ + E++ + V+++L + QS + E E
Sbjct: 1495 EHLETFKRENKNLQEEISDLTEQLGEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLE 1554
Query: 82 SEEHFKAIAQRELGRVKDEI------------------QRLENEMASILEKKSDKENGIF 123
EE AQ E ++K EI QR+ + + + L+ ++ N +
Sbjct: 1555 HEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVL 1614
Query: 124 KATQKLDG--------------LKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQD-- 167
+ +K++G + + ++L++ L+++ + DA+ +++
Sbjct: 1615 RVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIA 1674
Query: 168 -----DNKIRALTLQLERLTLECNQKRKILDNELTETISAQLEL------------DKAA 210
+N ++A +L + + + RK+ + EL ET S +++L K
Sbjct: 1675 IVERRNNLLQAELEELRAVVEQTERSRKLAEQELIET-SERVQLLHSQNTSLINQKKKME 1733
Query: 211 QDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLE 270
D ++ +E +E +++ N E+ +K I + A+ +K+E +L + K K +E
Sbjct: 1734 SDLTQLQSEVEEAVQECRNAEEKAKKA---ITDAAMMAEELKKEQDTSAHLERMK-KNME 1789
Query: 271 SEIGNNTEFEKRISVADRKLLKC-RTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALR 329
I + + R+ A++ LK + Q E +L+GEL+ A R + ++ +R
Sbjct: 1790 QTI---KDLQHRLDEAEQIALKGGKKQLQKLEARVRELEGELE---AEQKRNAESVKGMR 1843
Query: 330 KNISKIKK---DIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKA-TNLEDMLK--- 382
K+ +IK+ E+ L + ++ + +Q K+K + EE+A TNL K
Sbjct: 1844 KSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQH 1903
Query: 383 -----EEEKDVKEVDV 393
EE D+ E V
Sbjct: 1904 ELDEAEERADIAESQV 1919
Score = 58.2 bits (139), Expect = 4e-08
Identities = 87/396 (21%), Positives = 169/396 (42%), Gaps = 61/396 (15%)
Query: 21 NEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERET 80
+EE K+L QL + +A ++ +L E +E + + + V SL + + ET
Sbjct: 1555 HEEGKILRAQL-EFNQIKAEIERKLAEKDEEMEQAKRNHQRV------VDSLQTSLDAET 1607
Query: 81 ESEEHFKAIAQRELGRVKD-EIQRLE-NEMASILEKKSDKENGIFKATQKLDGLKCQMNW 138
S + ++ G + + EIQ N MA+ +K+ + K TQ + N
Sbjct: 1608 RSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRAND 1667
Query: 139 D-----------QQALEAWLEESAHKDSDALTLQKYAQQD--DNKIRALTLQLERLTLEC 185
D L+A LEE +K A+Q+ + R L + +L
Sbjct: 1668 DLKENIAIVERRNNLLQAELEELRAVVEQTERSRKLAEQELIETSERVQLLHSQNTSL-I 1726
Query: 186 NQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELI--------------------- 224
NQK+K ++++LT+ Q E+++A Q+ R + ++ I
Sbjct: 1727 NQKKK-MESDLTQL---QSEVEEAVQECRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1782
Query: 225 ---KQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNNTEFEK 281
K E TI+ +Q R + + AL+ K++ ++ E V+E LE+E N E K
Sbjct: 1783 RMKKNMEQTIKDLQHRLDEAEQIALKGG--KKQLQKLEARVRELEGELEAEQKRNAESVK 1840
Query: 282 RISVADRKLLKCRTAYQDHETSRIQLKGELDSL----KATVNRTSSDLEALRKNISKIKK 337
+ ++R++ + ++ + + ++L+ +D L KA + E N+SK +K
Sbjct: 1841 GMRKSERRIKELTYQTEEDKKNLLRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRK 1900
Query: 338 DIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEK 373
HE L + + +I ++++ ++ K+ + K
Sbjct: 1901 VQHE----LDEAEERADIAESQVNKLRAKSRDIGAK 1932
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 120 bits (300), Expect = 8e-27
Identities = 185/930 (19%), Positives = 397/930 (42%), Gaps = 115/930 (12%)
Query: 37 ERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKAIAQRELGR 96
E +L++E+ R+ + H K+ K+E ++ + E+E E H +E
Sbjct: 1317 EHHNLENEV----SRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKS 1372
Query: 97 VKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSD 156
++ E++ E+ ++K+ +++ I DG N + E +E+S D
Sbjct: 1373 LECEVE----ELHRTVQKRQQQKDFI-------DG-----NVESLMTELEIEKSLKHHED 1416
Query: 157 ALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKI 216
+ + ++ K R+ + +RL E + L +T +A + A + +
Sbjct: 1417 IVDEIECIEKTLLKRRSELREADRLLAEAESE---LSCTKEKTKNAVEKFTDAKRSLLQT 1473
Query: 217 HNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFL---ESEI 273
++ +EL ++ + T + K D + + + ++Q ++E ++KE K + +S+
Sbjct: 1474 ESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDF 1533
Query: 274 GNNTEFEKRISVADRKLLKCRTAYQDHETSRIQL-----------KGELDSLKATVNRTS 322
++ +++++ +KL K + +E +Q+ + EL+ LK+ V
Sbjct: 1534 QCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQ 1593
Query: 323 SDLEALRKNISKIKKDIH-EETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDML 381
++ L + + K+++H + + +Q + E ++ E+TEK + E + LE++
Sbjct: 1594 QEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREVKSLLEELS 1653
Query: 382 KEEEK---DVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQ 438
++ + + E QL LIK + K+ + LQ + +E++ L+ NH+LQ
Sbjct: 1654 FQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQ 1713
Query: 439 KLDF-------ETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSL 491
L E K Q + + ++ +++ + KGEI +KQ LE E+ +
Sbjct: 1714 GLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEI-EWQKQLLERDKREIERMT 1772
Query: 492 EEKKSTCGLLETQIKKLHN-----DLYFIKKAHSKN---SDEKQSLMTKIN--ELNLFID 541
E ++ +E K+ + D++ K A +K + E+ S M + N +L L +
Sbjct: 1773 AESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVR 1832
Query: 542 RSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTE 601
+ ++ELD+ K L + + ++ +++ RE ++S EE+ +++ L A ++
Sbjct: 1833 KLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQ---DHLNLAKQDLLH 1889
Query: 602 EIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQA 661
K +L+ Q R +++IS E+ R +K EE K Q
Sbjct: 1890 TTKHQDVLLSEQTRL----QKDIS-EWANRFEDCQK----------------EEETKQQQ 1928
Query: 662 YYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSD 721
V++ E+ +L+ + + +KE + E+ L+ KVT
Sbjct: 1929 LQVLQNEIEENKLKLVQQ--EMMFQRLQKERESEESKLET------------SKVTLKEQ 1974
Query: 722 EYELKIQLEEQKRAVDE---KYRYKQRQIRELQED---IQSMENTLDVIEHLANNVKEKL 775
+++L+ +L +QK +D+ K + ++R LQE+ +S+E TL + + +++L
Sbjct: 1975 QHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQL 2034
Query: 776 SEKQAYSFQLSKETEEQKPKLERVTKQC----AKLTKEIRLLKDTKDETMEEQDIKLREM 831
EK L KE + + + Q K K++ LK+ + + L E
Sbjct: 2035 VEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEALKIQRSQLEKNLLEQ 2094
Query: 832 KQFHKVIDEMLVDI---IEENTE-----IRIILQTYFQQSGLELPTASTKGSRQSSRSPS 883
KQ + I + + I ++N E ++ + Q ++ + L+ A+ K + S
Sbjct: 2095 KQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKDLERRQMEIS 2154
Query: 884 HTSLSARSSRSTSTSTSQSSIKVLELKFPA 913
+ +S TS ++ + PA
Sbjct: 2155 DAMRTLKSEVKDEIRTSLKNLNQFLPELPA 2184
Score = 108 bits (271), Expect = 2e-23
Identities = 149/742 (20%), Positives = 328/742 (44%), Gaps = 79/742 (10%)
Query: 183 LECN-QKRKILDNELT--ETISAQLELDKAAQDF-----RKIHNERQELIKQWENTIEQM 234
L CN + L+NE++ E I L+ K + + R+ E +EL ++ +++
Sbjct: 1311 LHCNVPEHHNLENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEK 1370
Query: 235 QKRDGDIDNCALELARIKQETREKENLVKEKIKFL------ESEIGNNTEFEKRISVADR 288
+ + +++ EL R Q+ +++++ + ++ L E + ++ + I ++
Sbjct: 1371 KSLECEVE----ELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEK 1426
Query: 289 KLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQK 348
LLK R+ ++ + + + EL K ++++ + + D E R Q+
Sbjct: 1427 TLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQE 1486
Query: 349 TKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDV--KEVDVQ-LNLIKGVLFKK 405
T + +L+ + +E+ E++LKE K V K+ D Q L+ K L ++
Sbjct: 1487 TAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEE 1546
Query: 406 AQELQTE-TMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERR 464
Q+LQ + M E+ ++ + S L Q ++ + E LK Q + SQ + ++R+
Sbjct: 1547 LQKLQKDIEMAERNEDHHLQVLKESEVLL--QAKRAELEKLKSQ--VTSQQQEMAVLDRQ 1602
Query: 465 MSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSD 524
+ K EE L+ +V+ + L+E L ET++ + N + +K + S
Sbjct: 1603 LGHKK-----EELHLLQGSMVQAKADLQE---ALRLGETEVTEKCNHIREVKSLLEELSF 1654
Query: 525 EKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLS 584
+K L +I+E + ++E++K + Q ++ + + K E+K +ML + E+
Sbjct: 1655 QKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKNILDMLQLENHELQG 1714
Query: 585 LEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEI 644
L+ + Q + + E+T+ + + + ++ + Q+++ E++++L +E+ K E
Sbjct: 1715 LKLQHDQRVSEL-EKTQVAVLEEKLELENLQQISQQQKG-EIEWQKQL--LERDKREIER 1770
Query: 645 LTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNS 704
+T E + V ++EKE+LQ + D + K+ + ++ + A E ++ S
Sbjct: 1771 MTA--------ESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQS 1822
Query: 705 CNNNYKQSFKKVTPSSDEYEL-KIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDV 763
+ + +K+ D+ K+ L A+ ++ + K+ + LQE++ ++++ L++
Sbjct: 1823 NLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNL 1882
Query: 764 -------------------------IEHLANNVKEKLSEKQAYSFQ---LSKETEEQKPK 795
I AN ++ E++ Q L E EE K K
Sbjct: 1883 AKQDLLHTTKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLK 1942
Query: 796 LERVTKQCAKLTKEIRLLK---DTKDETMEEQDIKL-REMKQFHKVIDEMLVDIIEENTE 851
L + +L KE + +T T++EQ +L +E+ +D++L ++
Sbjct: 1943 LVQQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEER 2002
Query: 852 IRIILQTYFQQSGLELPTASTK 873
+R + + LE + TK
Sbjct: 2003 VRTLQEEERWCESLEKTLSQTK 2024
Score = 103 bits (258), Expect = 6e-22
Identities = 160/820 (19%), Positives = 350/820 (42%), Gaps = 111/820 (13%)
Query: 19 VANEENKLL---EDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKA 75
+ E NK++ + L ++ L +EL++ ++ I + + Q L ++ L +A
Sbjct: 1518 ILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQA 1577
Query: 76 RERETE-------SEEHFKAIAQRELGRVKDEIQRLENEM----ASILE-------KKSD 117
+ E E S++ A+ R+LG K+E+ L+ M A + E + ++
Sbjct: 1578 KRAELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTE 1637
Query: 118 KENGIFKATQKLDGLKCQMN------WDQQALEAWLEESAHKDSDAL-----TLQKYAQQ 166
K N I + L+ L Q +++ +++ K+ + L + K+ +
Sbjct: 1638 KCNHIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTE 1697
Query: 167 DDNKIRALTL---QLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNE---R 220
N + L L +L+ L L+ +Q+ L+ + +LEL+ Q ++ E +
Sbjct: 1698 LKNILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEIEWQ 1757
Query: 221 QELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKI----KFLESEIGNN 276
++L+++ + IE+M + +C L++ K++ +EK ++ ++K+ + L + N+
Sbjct: 1758 KQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENS 1817
Query: 277 TEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIK 336
+ + + + K + ++ L ++ +++ + + +L++ ++ ++
Sbjct: 1818 KMEQSNLEKLELNVRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQ 1877
Query: 337 KDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLN 396
++ L T H +++ L E T + E A ED KEEE +++ V N
Sbjct: 1878 DHLNLAKQDLLHTTKHQDVL---LSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQN 1934
Query: 397 LIKGVLFKKAQE------LQTETMKEKAVLSEIEGTRSSLKHLNHQLQK-LDFETLKQQE 449
I+ K Q+ LQ E E+ S++E ++ +LK HQL+K L + K +
Sbjct: 1935 EIEENKLKLVQQEMMFQRLQKERESEE---SKLETSKVTLKEQQHQLEKELTDQKSKLDQ 1991
Query: 450 I-------------MYSQDFHIQQVERRMSRLKGEINSEEKQALE--AKIVELRKSLEEK 494
+ + ++ + +E+ +S+ K +++ E+Q +E +++ L+K +
Sbjct: 1992 VLSKVLAAEERVRTLQEEERWCESLEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSM 2051
Query: 495 KSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINEL--NLFIDRSE-----KEL 547
++ LL Q L KKA + + K++L + ++L NL + E KE+
Sbjct: 2052 RADFSLLRNQF------LTERKKAEKQVASLKEALKIQRSQLEKNLLEQKQENSCIQKEM 2105
Query: 548 DKAKGFKQD-------LMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERT 600
+ QD LM E N ++ E ++ + ++ + LE+R+ ++ AM
Sbjct: 2106 ATIELVAQDNHERARRLMKELNQMQYEYTELKKQMANQKD----LERRQMEISDAMRTLK 2161
Query: 601 EEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEIL--TVVMLPPEGEEEK 658
E+ K + + ++ ++Q + + L + E L+ E L + EG E+
Sbjct: 2162 SEV---KDEIRTSLKNLNQFLPELPADLEAILERNENLEGELESLKENLPFTMNEGPFEE 2218
Query: 659 TQAYYVIKAAQE-------KEELQREGDCLDAKI-----NKAEKEIYALENTLQVLNSCN 706
+ + E +E+L+ D L A++ +AE I T L+S
Sbjct: 2219 KLNFSQVHIMDEHWRGEALREKLRHREDRLKAQLRHCMSKQAEVLIKGKRQTEGTLHSLR 2278
Query: 707 NNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQ 746
+ VT +S + L + + ++ E + Q Q
Sbjct: 2279 RQVDALGELVTSTSADSASSPSLSQLESSLTEDSQLGQNQ 2318
Score = 75.9 bits (185), Expect = 2e-13
Identities = 147/748 (19%), Positives = 316/748 (42%), Gaps = 109/748 (14%)
Query: 28 EDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFK 87
E ++S + + L DE+ + E++I T FK +++ + + + E + +K
Sbjct: 443 EKKISAAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQL------KKISEAGKDLLYK 496
Query: 88 AIAQR--ELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGL----------KCQ 135
++ R + +++ E LE +M ++ + K+ I +D L K Q
Sbjct: 497 QLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQ 556
Query: 136 MNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQK-RKILD- 193
+ +Q L+ ++ +S + ++ +I+ L QL + N+ +K L+
Sbjct: 557 KSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEG 616
Query: 194 -----NELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALEL 248
E TI Q +A + RK+ +E++ L+ + E Q+RD ++ A++
Sbjct: 617 VISGLQEYLGTIKGQ--ATQAQNECRKLRDEKETLL---QRLTEVEQERD-QLEIVAMDA 670
Query: 249 ARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLK 308
+++E E E+ ++E + E+ + + + A L+ R +D E + QLK
Sbjct: 671 ENMRKELAELESALQE-----QHEVNASLQQTQGDLSAYEAELEARLNLRDAEAN--QLK 723
Query: 309 GELDSLKATVNRTSSDLEA-LRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKT 367
EL+ + S L+A L K +K + + +K + ++E + KLK + +
Sbjct: 724 EELEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSE-LHAKLKHLQDD- 781
Query: 368 MSVEEKATNLEDMLKEEEKDVKEVDVQLN-LIKGVLFKKAQELQTETMKEKAVLSEIEGT 426
++LK++ KD + LN ++ G++ + + + ++ K L GT
Sbjct: 782 ----------NNLLKQQLKDFQN---HLNHVVDGLVRPEEVAARVDELRRKLKL----GT 824
Query: 427 RSSLKHLNHQLQKLDFETLKQQ--EIMYSQDFHIQQVERRMSRLKGEI----------NS 474
H + L++Q EI+ + + + R +L+ E+
Sbjct: 825 GEMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQE 884
Query: 475 EEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKIN 534
E +QA E + +E R + ++++ E +I+++ N+++++++ + K+ +E Q L
Sbjct: 885 EFRQACE-RALEARMNFDKRQH-----EARIQQMENEIHYLQE-NLKSMEEIQGL----- 932
Query: 535 ELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYT 594
++ +L +A K+ ++ + L +LE K+ E S+ E+V L+K ++L
Sbjct: 933 --------TDLQLQEADEEKERILAQ--LRELEKKKKLEDAKSQ-EQVFGLDKELKKLKK 981
Query: 595 AMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEG 654
A+ + T+ Q++ + I+ E E L + E+ + + E
Sbjct: 982 AVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEA 1041
Query: 655 EEEKTQAYYVIKAAQEKEELQREG------------DCLDAKINKAEKEIYALENTLQVL 702
E E Q K Q + E+++ G + L+ + + EI L+N L +
Sbjct: 1042 EIELLQNLLRQKGEQFRLEMEKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLT 1101
Query: 703 NSCNNNYKQSFKKVTPSSDEYELKIQLE 730
S N K F+ V E ++ +
Sbjct: 1102 GSDN---KGGFENVLEEIAELRREVSYQ 1126
Score = 70.5 bits (171), Expect = 7e-12
Identities = 163/864 (18%), Positives = 345/864 (39%), Gaps = 146/864 (16%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETE 81
EE + LE L K E L+ + + E I + K++K+E + + C+ + +
Sbjct: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLN 329
Query: 82 SEEHFKAIAQRELGRVKDEIQRLENEMASI-LEKKSDKENGIFKATQKLDGL-------- 132
++ EL R + LE E+A ++ K + N ++D
Sbjct: 330 TKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIG 389
Query: 133 KCQMNWDQQALEAWLEESAHK-DSDALTLQKYAQQDDNKIRA---LTLQLERLTLECNQK 188
K + + A E+++ +SA + + + D +R L QLE + +
Sbjct: 390 KSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAA 449
Query: 189 RKILDNELTETISAQLELDKAAQDFRKIHNERQE----------LIKQWENTIEQMQKRD 238
+ L E A+ ++ +A ++F+++ Q L KQ ++ + K
Sbjct: 450 QTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLR 509
Query: 239 GDIDNCALELARIKQETREKENLVKE---KIKFLESEIGNNTEFEKRISVADRKLLKCRT 295
+ + L++ + KQE K+ +K+ I L+S+ ++ + + S +++L
Sbjct: 510 QEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNK 569
Query: 296 AYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEI 355
YQ QL+ LD + + + + + +++ L + +++ + A + K E
Sbjct: 570 QYQ-------QLESRLDEILSRIAKETEEIKDLEEQLTE------GQIAANEALKKDLEG 616
Query: 356 IQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMK 415
+ + L+E +A N L++E K L ++ E++ E +
Sbjct: 617 VISGLQEYLGTIKGQATQAQNECRKLRDE--------------KETLLQRLTEVEQERDQ 662
Query: 416 EKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSE 475
+ V + E R L L LQ+ Q E+ S +QQ + +S + E+ +
Sbjct: 663 LEIVAMDAENMRKELAELESALQE-------QHEVNAS----LQQTQGDLSAYEAELEAR 711
Query: 476 EKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINE 535
L + E + EE + L + + L +L E+Q+L + +
Sbjct: 712 ----LNLRDAEANQLKEELEKVTRLTQLEQSALQAEL----------EKERQALKNALGK 757
Query: 536 LNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEK---RKQQL 592
F + E+E + + L ++NLLK ++K + L+ + ++ E+ R +L
Sbjct: 758 AQ-FSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDEL 816
Query: 593 YTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPP 652
++ T E+ +H S + + ++ +F E L++
Sbjct: 817 RRKLKLGTGEMNIH-----SPSDVLGKSLADLQKQFSEILAR------------------ 853
Query: 653 EGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQS 712
+ E+ +A + QE+ LQ+E K+ ++E ++Q+
Sbjct: 854 -SKWERDEAQVRERKLQEEMALQQE------KLATGQEE-----------------FRQA 889
Query: 713 FKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLAN-NV 771
++ L+ ++ KR + + + + +I LQE+++SME I+ L + +
Sbjct: 890 CERA--------LEARMNFDKRQHEARIQQMENEIHYLQENLKSMEE----IQGLTDLQL 937
Query: 772 KEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKD---TKDE-TMEEQDIK 827
+E EK+ QL + +++K + + +Q L KE++ LK T D+ E I
Sbjct: 938 QEADEEKERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIA 997
Query: 828 LREMKQFHKVIDEMLVDIIEENTE 851
++K H + ++ + EE E
Sbjct: 998 KDQLKSLHGTVMKINQERAEELQE 1021
Score = 55.1 bits (131), Expect = 3e-07
Identities = 114/579 (19%), Positives = 225/579 (38%), Gaps = 97/579 (16%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARER------ET 80
L++ L +K + Q+E R+ + ++ V+QE + + E E
Sbjct: 621 LQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAEL 680
Query: 81 ESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQ 140
ES + L + + ++ E E+ + L + + N + + +K+ L +Q
Sbjct: 681 ESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKVTRL---TQLEQ 737
Query: 141 QALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECN---QKRKILDNELT 197
AL+A LE+ +AL +++++ + + L +L+ L + N Q+ K N L
Sbjct: 738 SALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLN 797
Query: 198 ETISAQLELDKAA---QDFRK----------IHNERQELIKQWENTIEQMQKRDGDIDNC 244
+ + ++ A + R+ IH+ L K ++ +QK+ +I
Sbjct: 798 HVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGK----SLADLQKQFSEI--- 850
Query: 245 ALELARIKQETRE---KENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHE 301
LAR K E E +E ++E++ + ++ E A + L+ R + +
Sbjct: 851 ---LARSKWERDEAQVRERKLQEEMALQQEKLATGQE---EFRQACERALEARMNFDKRQ 904
Query: 302 TSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLK 361
+A + + +++ L++N+ +++ +LQ+ E I +L+
Sbjct: 905 H------------EARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLR 952
Query: 362 EITEK----TMSVEEKATNLEDMLKEEEKDVKEVDV-----------QLNLIKGVLFK-- 404
E+ +K +E+ L+ LK+ +K V D QL + G + K
Sbjct: 953 ELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKIN 1012
Query: 405 --KAQELQ-TETMKEKAVL---------SEIEGTRSSLKHLNHQLQKLDFETLKQQEIMY 452
+A+ELQ E KA +EIE ++ L+ Q +L+ E
Sbjct: 1013 QERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQF-RLEMEKTGVGTGAN 1071
Query: 453 SQDFHIQQVERRMSRLKGEI----------NSEEKQALE---AKIVELRKSLEEKKSTCG 499
SQ I+++ M R + EI S+ K E +I ELR+ + +
Sbjct: 1072 SQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAELRREVSYQNDYIS 1131
Query: 500 LLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNL 538
+ K+ YF+ S S TK + + L
Sbjct: 1132 SMADPFKR-RGYWYFMPPPPSSKVSSHSSQATKDSGVGL 1169
Score = 53.9 bits (128), Expect = 7e-07
Identities = 89/407 (21%), Positives = 178/407 (43%), Gaps = 51/407 (12%)
Query: 433 LNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLE 492
L H LQ F L+ E + Q Q + R E ++ LE K++E E
Sbjct: 233 LPHYLQFTIFH-LRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEKKMIET----E 287
Query: 493 EKKSTCGLLETQIK---KLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDK 549
E KS +IK KL+ L ++ +E +S + NEL +K ++
Sbjct: 288 ELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNEL-----LKQKTIEL 342
Query: 550 AKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTM 609
+ ++ +E L ++ E L+ E ++K + + R + + M
Sbjct: 343 TRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGKSRYK-----RNM 397
Query: 610 LASQIRYVDQERENISTEFRERLSKIEKLKNRYEIL---TVVMLPPEGEEEKTQAYYVIK 666
A++ +D + + + + ++ E+L+N + L T + E +E+K I
Sbjct: 398 FATESYIIDSAQ---AVQIK-KMEPDEQLRNDHMNLRGHTPLDTQLEDKEKK------IS 447
Query: 667 AAQEK-EELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPS------ 719
AAQ + EL E + + +I +A +E LE +Q+ +K+++
Sbjct: 448 AAQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNK 507
Query: 720 --SDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSE 777
+ +L++Q+E+QK+ + K Q++I++LQ I S+++ H+ K + S
Sbjct: 508 LRQEALDLELQMEKQKQEIAGK----QKEIKDLQIAIDSLDSKDPKHSHM----KAQKSG 559
Query: 778 KQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQ 824
K+ ++K+ ++ + +L+ + + AK T+EI KD +++ E Q
Sbjct: 560 KEQQLDIMNKQYQQLESRLDEILSRIAKETEEI---KDLEEQLTEGQ 603
Score = 42.7 bits (99), Expect = 0.002
Identities = 75/339 (22%), Positives = 141/339 (41%), Gaps = 42/339 (12%)
Query: 540 IDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEER 599
++R E++L+K ++L + E+K ++ S EE + ++ ++L + + +
Sbjct: 272 VERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTK 331
Query: 600 TEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRY--EILTVVMLPPEGEEE 657
E +K KT+ ++ E E F + +K E L N Y E + P E
Sbjct: 332 NELLK-QKTIELTRACQKQYELEQ-ELAFYKIDAKFEPL-NYYPSEYAEIDKAPDESPYI 388
Query: 658 KTQAY---------YVIKAAQEKEELQREGD--------------CLDAKINKAEKEIYA 694
Y Y+I +AQ + + E D LD ++ EK+I A
Sbjct: 389 GKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISA 448
Query: 695 LENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDI 754
+ L L+ +Q + T + E IQL++ A + YKQ R LQ
Sbjct: 449 AQTRLSELHDEIEKAEQQILRATEEFKQLEEAIQLKKISEA-GKDLLYKQLSGR-LQLVN 506
Query: 755 QSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLK 814
+ + LD +E K++++ KQ KE ++ + ++ + + K + +K
Sbjct: 507 KLRQEALD-LELQMEKQKQEIAGKQ-------KEIKDLQIAIDSLDSKDPKHSH----MK 554
Query: 815 DTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIR 853
K ++ DI ++ +Q +DE+L I +E EI+
Sbjct: 555 AQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIK 593
Score = 42.0 bits (97), Expect = 0.003
Identities = 65/364 (17%), Positives = 155/364 (42%), Gaps = 52/364 (14%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERET- 80
+EN L +L L+D+ L+ +L++++ +N + ++ + L + + T
Sbjct: 766 QENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTG 825
Query: 81 ------ESEEHFKAIA--QRELGRV-------KDEIQ----RLENEMASILEKKSDKENG 121
S+ K++A Q++ + +DE Q +L+ EMA EK + +
Sbjct: 826 EMNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVRERKLQEEMALQQEKLATGQEE 885
Query: 122 IFKATQKLDGLKCQMNWDQQALEAWLEE------------SAHKDSDALTLQKYAQQDDN 169
+A ++ L+ +MN+D++ EA +++ + ++ LT + + D+
Sbjct: 886 FRQACER--ALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEE 943
Query: 170 KIRALT----LQLERLTLECNQKRKI--LDNEL--------TETISAQLELDKAAQDFRK 215
K R L L+ ++ + + ++ LD EL T A EL A +
Sbjct: 944 KERILAQLRELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKS 1003
Query: 216 IHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGN 275
+H ++ ++ +++ ++ A +L R + E +NL+++K + E+
Sbjct: 1004 LHGTVMKINQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEM-- 1061
Query: 276 NTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKI 335
E + A+ ++L+ + E R ++ + L T + E + + I+++
Sbjct: 1062 --EKTGVGTGANSQVLEIEKLNETMERQRTEIARLQNVLDLTGSDNKGGFENVLEEIAEL 1119
Query: 336 KKDI 339
++++
Sbjct: 1120 RREV 1123
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 119 bits (297), Expect = 2e-26
Identities = 156/733 (21%), Positives = 326/733 (44%), Gaps = 121/733 (16%)
Query: 114 KKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRA 173
KK NG T G C D+Q +++H+ +AL + AQ + IR
Sbjct: 86 KKKKINNGTNPETTTSGG--CHSPEDEQ-------KASHQHQEALRRELEAQV--HTIRI 134
Query: 174 LTLQLERLTLECNQKR---KILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENT 230
LT Q L + + K L+ E + IS + K A + + + K+ +
Sbjct: 135 LTCQKTELQMALYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRY 194
Query: 231 IEQMQKRDGDIDNCALELAR---IKQETREKENLVKEKIKFLESEIGNNTEFEKRISVAD 287
IE++ K + D +LEL R +E +EK ++EK++ +ESE +E + +
Sbjct: 195 IEELTK---ERDALSLELYRNTITDEELKEKNAKLQEKLQLVESE---KSEIQLNVKELK 248
Query: 288 RKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQ 347
RKL + + QL+ E D L + S+ L+A + + +E RL
Sbjct: 249 RKLERAKLLLPQQ-----QLQAEADHLGKELQSVSAKLQA--------QVEENELWNRL- 294
Query: 348 KTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQ 407
N+ + K+ EK EEK E+ ++E+E+ ++E + ++ + ++++K +
Sbjct: 295 -----NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE 349
Query: 408 EL--QTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRM 465
++ Q E M EK ++ + + + + +Q+E+M+ ++ I+++E +M
Sbjct: 350 KMRRQEEMMWEK---------EEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 400
Query: 466 SRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSK--NS 523
+ EEK+ E KI E K E++ + Q +K+ I++ K
Sbjct: 401 HEQEKIREQEEKRQEEEKIREQEKRQEQEAK----MWRQEEKIREQEEKIREQEKKMWRQ 456
Query: 524 DEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVL 583
+EK KI E EK ++ + ++Q+ I + + E+ R +E +H + E++
Sbjct: 457 EEKIHEQEKIRE-------EEKRQEQEEMWRQEEKIHE---QEEIWRQKEKMHEQEEKIR 506
Query: 584 SLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYE 643
E++ + + E+ E+I+ + + Q + ++ E E E++ + EK+
Sbjct: 507 KQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREE--EKMHEQEKI----- 559
Query: 644 ILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLN 703
EEEK Q ++++++ R+ + KI + E++++ E ++
Sbjct: 560 ----------WEEEKRQ--------EQEDKMWRQ----EEKIREQEEKVWRQEEKIR--- 594
Query: 704 SCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDV 763
++ E + + EE+ +EK R ++ +I+E +E I+ E +
Sbjct: 595 -----------------EQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIRE 637
Query: 764 IEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKD---TKDET 820
E + +EK+ E++ + ++ +EQ+ + R ++ + K+IR ++ ++E
Sbjct: 638 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM 697
Query: 821 MEEQDIKLREMKQ 833
M+EQ+ K+ E ++
Sbjct: 698 MQEQEEKMWEQEE 710
Score = 84.0 bits (206), Expect = 6e-16
Identities = 104/490 (21%), Positives = 231/490 (47%), Gaps = 47/490 (9%)
Query: 22 EENKLLEDQLSKLKDERASLQDE-LREYEERINSMTSHFKNVKQELSITQSLCKARERET 80
EEN+L ++L++ ++E+ Q+E ++E+EE+I +QE I + K RE+E
Sbjct: 286 EENELW-NRLNQQQEEKMWRQEEKIQEWEEKIQ---------EQEEKIREQEEKIREQEE 335
Query: 81 ESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQ 140
+ Q E+ K+E R + EM E+K ++ + ++ + +M W++
Sbjct: 336 KMRR------QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 389
Query: 141 QALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETI 200
+ LEE H + + + Q+ +Q++ KIR + E+ Q+ KI + E E I
Sbjct: 390 EEKIRELEEKMH-EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE--EKI 446
Query: 201 SAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKEN 260
Q + K + KIH + + ++ E+M +++ I E+ R K++ E+E
Sbjct: 447 REQEK--KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQE-EIWRQKEKMHEQEE 503
Query: 261 LVK----------EKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQD----HETSRIQ 306
++ EKI+ E +I E E+++ + K+ + +++ HE +I
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKI---REQEEKMWRQEEKIREQEEMWREEEKMHEQEKIW 560
Query: 307 LKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEK 366
+ + + + R + + + + ++ I E+ + Q+ + + K++E EK
Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620
Query: 367 TMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGT 426
EEK E+ ++E+E+ +E + ++ + + ++ +++Q + E+ + + E
Sbjct: 621 IQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQ---EETMWRQEEKI 677
Query: 427 RSSLKHLNHQLQKLDFET---LKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAK 483
R K + Q +K+ + +Q+E M+ Q+ + + E +M + ++ +E++ E +
Sbjct: 678 REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 737
Query: 484 IVELRKSLEE 493
V LR+ E+
Sbjct: 738 -VRLRQQEEK 746
Score = 76.6 bits (187), Expect = 1e-13
Identities = 113/670 (16%), Positives = 288/670 (42%), Gaps = 62/670 (9%)
Query: 28 EDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFK 87
ED+ + +L+ EL I +T ++ L +Q K E E
Sbjct: 108 EDEQKASHQHQEALRRELEAQVHTIRILTCQKTELQMALYYSQHAVKQLEGE-------- 159
Query: 88 AIAQRELGRVKDEIQ---RLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALE 144
A+ + R+ D + LE ++++ +K + I + T++ D L ++ + E
Sbjct: 160 --ARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDE 217
Query: 145 AWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKR-----KILDNELTET 199
E++A ++ + ++ L +LER L Q++ L EL ++
Sbjct: 218 ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL-QS 276
Query: 200 ISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKE 259
+SA+L+ + N++QE E+M +++ I ++ +++ RE+E
Sbjct: 277 VSAKLQAQVEENELWNRLNQQQE---------EKMWRQEEKIQEWEEKIQEQEEKIREQE 327
Query: 260 NLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVN 319
++E+ + + + E+ + + K+ + + E + + + + +
Sbjct: 328 EKIREQEEKMRRQ-------EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMR 380
Query: 320 RTSSDLEALRKNISKIKKDIHE-ETARLQKTKNHNEII---QTKLKEITEKTMSVEEKAT 375
R + + I ++++ +HE E R Q+ K E Q K +E K EEK
Sbjct: 381 RQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR 440
Query: 376 NLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNH 435
E+ ++E+EK + + +++ + + ++ ++ Q E +++ + E E + ++
Sbjct: 441 EQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE 500
Query: 436 QLQKL---DFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQ-ALEAKIVELRKSL 491
Q +K+ + + +Q+E + Q+ I++ E +M R + +I +E+ E K+ E K
Sbjct: 501 QEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIW 560
Query: 492 EEKKSTCG---------LLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDR 542
EE+K + Q +K+ I++ K ++++ + + ++ ++
Sbjct: 561 EEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEK 620
Query: 543 SEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAME----- 597
+++ +K + ++ + ++ + + + ++ E E+ ++++++ ++ E
Sbjct: 621 IQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQ 680
Query: 598 -----ERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPP 652
E+ E+I+ + M+ Q + ++ E + + + + EK++ + E + +
Sbjct: 681 EKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 740
Query: 653 EGEEEKTQAY 662
+EEK Q +
Sbjct: 741 RQQEEKMQEH 750
Score = 69.3 bits (168), Expect = 2e-11
Identities = 80/388 (20%), Positives = 174/388 (44%), Gaps = 24/388 (6%)
Query: 8 ELHWEDGFAIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELS 67
E+ WE I E K+ E + + ++E+ ++++RE E+R K +QE
Sbjct: 384 EMMWEKEEKI--RELEEKMHEQEKIREQEEKRQEEEKIREQEKR---QEQEAKMWRQEEK 438
Query: 68 ITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQ 127
I + K RE+E + + I ++E ++++E +R E E E+K ++ I++ +
Sbjct: 439 IREQEEKIREQEKKMWRQEEKIHEQE--KIREEEKRQEQEEMWRQEEKIHEQEEIWRQKE 496
Query: 128 KLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQ 187
K+ + ++ +Q + W +E ++ + +K +Q++ R E+ + +
Sbjct: 497 KMHEQEEKIR--KQEEKVWRQEEKIREQE----EKIREQEEKMWRQEEKIREQEEMWREE 550
Query: 188 KRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALE 247
++ ++ E Q + DK + KI + +++ +Q E EQ +KR E
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQ------E 604
Query: 248 LARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQL 307
KQE + +E +EKI+ E +I E E++I + + + E +
Sbjct: 605 EKMWKQEEKIREQ--EEKIQEQEEKI---REQEEKIREQEEMTQEQEEKMGEQEEKMCEQ 659
Query: 308 KGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKT 367
+ ++ + T+ R + K I + ++ I E+ +Q+ + + K+ E EK
Sbjct: 660 EEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKM 719
Query: 368 MSVEEKATNLEDMLKEEEKDVKEVDVQL 395
EEK E+ + E+E +++ + ++
Sbjct: 720 QEQEEKMRRQEEKMWEQEVRLRQQEEKM 747
Score = 68.2 bits (165), Expect = 4e-11
Identities = 97/484 (20%), Positives = 210/484 (43%), Gaps = 53/484 (10%)
Query: 371 EEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSL 430
E+KA++ + +E +E++ Q++ I+ +L + ELQ + + ++EG L
Sbjct: 110 EQKASH-----QHQEALRRELEAQVHTIR-ILTCQKTELQMALYYSQHAVKQLEGEARDL 163
Query: 431 KHLNHQLQKLDFETLKQQEIMYSQ----DFHIQQVERRMSRLKGEI--NSEEKQALEAKI 484
H K E + + +Q D +I+++ + L E+ N+ + L+ K
Sbjct: 164 ISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKN 223
Query: 485 VELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSE 544
+L++ L+ +S ++ +K+L L E+ L+ +L D
Sbjct: 224 AKLQEKLQLVESEKSEIQLNVKELKRKL------------ERAKLLLPQQQLQAEADHLG 271
Query: 545 KELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIK 604
KEL Q + E+ L ++ E + + E++ E++ Q+ + E+ E+I+
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 605 VHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYV 664
+ + Q + ++ E + + K EK++ + E++ E EE+ + +
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW------EKEEKMRRQEEM 385
Query: 665 IKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYE 724
+ EKEE RE L+ K+++ EK I E Q K+ E E
Sbjct: 386 M---WEKEEKIRE---LEEKMHEQEK-IREQEEKRQEEEKIREQEKRQ---------EQE 429
Query: 725 LKIQLEEQK-RAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSF 783
K+ +E+K R +EK R +++++ +E I E + + + EK
Sbjct: 430 AKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQE 489
Query: 784 QLSKETEEQKPKLERVTKQCAKLTKEIRLLKD------TKDETMEEQDIKLREMKQFHKV 837
++ ++ E+ + E++ KQ K+ ++ +++ ++E M Q+ K+RE ++ +
Sbjct: 490 EIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWRE 549
Query: 838 IDEM 841
++M
Sbjct: 550 EEKM 553
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 119 bits (297), Expect = 2e-26
Identities = 176/867 (20%), Positives = 371/867 (42%), Gaps = 116/867 (13%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSI-TQSLCKARER------- 78
++++ K K+E A + + +E EE++ ++ +++ ++ SL A ER
Sbjct: 856 MKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCDQLIKT 915
Query: 79 ETESEEHFKAIAQR--------------------ELGRVKDEIQRLENEMASILEKKSDK 118
+ + E K + +R E +K +I LE +A + ++K
Sbjct: 916 KIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHAT 975
Query: 119 ENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQL 178
EN + T+++ GL D+ + E+ A +++ TL Q +++K+ LT
Sbjct: 976 ENKVKNLTEEMAGL------DETIAKLTKEKKALQEAHQQTLDD-LQAEEDKVNTLT--- 1025
Query: 179 ERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRD 238
+ ++ Q+ L+ L + +++L++A + QE EN +Q+ D
Sbjct: 1026 -KAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQL---D 1081
Query: 239 GDIDNCALELARIKQETREKENL---VKEKIKFLESEIGNNTEFEKRISVADRKLLKCRT 295
+ E++ ++ + +++ L +++KIK L++ I E E+ I + + +
Sbjct: 1082 EKLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARI---EELEEEIEA--ERASRAKA 1136
Query: 296 AYQDHETSRIQLKGELDSLKATVNRTSSDLEALRK---NISKIKKDIHEETARLQKT--- 349
Q + SR +L+ + L+ TS+ +E +K K+++D+ E T + + T
Sbjct: 1137 EKQRSDLSR-ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAAT 1195
Query: 350 --KNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQ 407
K H + + +L E + V++K + +K E D+ ++ KG L K +
Sbjct: 1196 LRKKHADSV-AELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCR 1254
Query: 408 ELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSR 467
L+ + + K ++ E + + L Q +L E+ + + +D + Q+ R
Sbjct: 1255 ALEDQLSEIK---TKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSR---- 1307
Query: 468 LKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQ 527
KQA +I EL++ LEE+ L ++ +D +++ + + + K
Sbjct: 1308 --------GKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKA 1359
Query: 528 SLMTKINELNLFID--RSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSL 585
L +++ N + R++ E D + ++L L ++ E + + + SL
Sbjct: 1360 ELQRAMSKANSEVAQWRTKYETDAIQR-TEELEEAKKKLAQRLQDAEEHVEAVNAKCASL 1418
Query: 586 EKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKL------- 638
EK KQ+L +E+ +++ A+ +D+++ N E K E+
Sbjct: 1419 EKTKQRLQNEVEDLMIDVERTNAACAA----LDKKQRNFDKILAEWKQKCEETHAELEAS 1474
Query: 639 -KNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALEN 697
K + T + EE +K +E + LQ+E L +I + K I+ LE
Sbjct: 1475 QKESRSLSTELFKIKNAYEESLDQLETLK--RENKNLQQEISDLTEQIAEGGKRIHELEK 1532
Query: 698 TLQVLNSCNNNYKQSFKKVTPSSDEYE---LKIQLE--EQKRAVDEKYRYKQRQIRELQE 752
+ + + + + ++ S + E L+IQLE + K VD K K +I +++
Sbjct: 1533 IKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKR 1592
Query: 753 D----IQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTK 808
+ ++SM++TLD E + N +L +K + + E + +L + A+ +
Sbjct: 1593 NHIRIVESMQSTLDA-EIRSRNDAIRLKKK------MEGDLNEMEIQLNHANRMAAEALR 1645
Query: 809 EIR----LLKDTK----DETMEEQDIK 827
R +LKDT+ D ++D+K
Sbjct: 1646 NYRNTQAILKDTQLHLDDALRSQEDLK 1672
Score = 116 bits (290), Expect = 1e-25
Identities = 187/964 (19%), Positives = 405/964 (42%), Gaps = 146/964 (15%)
Query: 22 EENKLLEDQLSKLKDERASLQ-------DELREYEERINSMTSHFKNVKQELSITQSLCK 74
EE L++ ++KL E+ +LQ D+L+ E+++N++T ++Q++ + +
Sbjct: 984 EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLEQQVDDLEGSLE 1043
Query: 75 ARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKE---NGIFKATQKLDG 131
++ E K + +L ++ +EN+ + EK KE +G+ +
Sbjct: 1044 QEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQA 1103
Query: 132 LKCQMNWDQQALEAWLEESAHK-DSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRK 190
L Q+ + L+A +EE + +++ + K +Q + R L ERL
Sbjct: 1104 LGMQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERL--------- 1154
Query: 191 ILDNELTETISAQLELDKAAQ-DFRKIHNERQELIKQWENTIEQMQKRDGD--------I 241
E SAQ+E++K + +F+K+ + +E Q E T ++K+ D I
Sbjct: 1155 ---EEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQI 1211
Query: 242 DNCALELARIKQETREKENLVKEKIKFLESEIGNNTE----FEKRISVADRKLLKCRTAY 297
DN L R+KQ+ ++++ +K +I L S + ++ EK + +L + +T
Sbjct: 1212 DN----LQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKE 1267
Query: 298 QDH---------ETSRIQLKG-----ELDSLKATVNRTSSDLEALRKNISKIKKDIHEE- 342
++ + +R+Q + +LD V++ S +A + I ++K+ + EE
Sbjct: 1268 EEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEI 1327
Query: 343 ------------------------------TARLQK--TKNHNEIIQTKLK---EITEKT 367
A LQ+ +K ++E+ Q + K + ++T
Sbjct: 1328 KAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRT 1387
Query: 368 MSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTR 427
+EE L L++ E+ V+ V+ + L K Q LQ E + ++ ++E T
Sbjct: 1388 EELEEAKKKLAQRLQDAEEHVEAVNAKC----ASLEKTKQRLQNEV---EDLMIDVERTN 1440
Query: 428 SSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVEL 487
++ L+ + + D + L + + Q+ E + L E + +E ++L ++ ++
Sbjct: 1441 AACAALDKKQRNFD-KILAEWK---------QKCEETHAEL--EASQKESRSLSTELFKI 1488
Query: 488 RKSLEEKKSTCGLLETQIKKLHNDLYFI--------KKAHSKNSDEKQSLMTKINELNLF 539
+ + EE L+ + K L ++ + K+ H +KQ K +EL
Sbjct: 1489 KNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEK-SELQAA 1547
Query: 540 IDRSEKELDKAKGFKQDLMIEDNLLKLEVKR-----TREMLHSKAEEVLSLEKRKQQLYT 594
++ +E L+ +G + +E N +K EV R E+ K + +E + L
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTLDA 1607
Query: 595 AMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEG 654
+ R + I++ K M +++ ++ R + +N IL L +
Sbjct: 1608 EIRSRNDAIRLKKKMEGD----LNEMEIQLNHANRMAAEALRNYRNTQAILKDTQLHLDD 1663
Query: 655 -----EEEKTQAYYVIKAAQ----EKEELQREGDCLDAKINKAEKEIYALENTLQVLNSC 705
E+ K Q V + A E EEL+ + + AE+E+ +Q+L++
Sbjct: 1664 ALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQ 1723
Query: 706 NNNYKQSFKKVTPSSDEYELKIQ-LEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVI 764
N + + KK+ + + +++ + ++ R +EK + + E+++ ++T +
Sbjct: 1724 NTSLINTKKKLETDISQIQGEMEDIIQEARNAEEKAKKAITDAAMMAEELKKEQDTSAHL 1783
Query: 765 EHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQ 824
E + N+++ + + Q + E ++ L+ KQ KL +R L+ + +
Sbjct: 1784 ERMKKNLEQTVKDLQ------HRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRN 1837
Query: 825 DIKLREMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSH 884
++ +++ + + E+ E+ I + LQ + L+ S K + + S+
Sbjct: 1838 VEAVKGLRKHERKVKELTYQTEEDRKNI-LRLQDLVDK--LQAKVKSYKRQAEEAEEQSN 1894
Query: 885 TSLS 888
+LS
Sbjct: 1895 VNLS 1898
Score = 103 bits (256), Expect = 1e-21
Identities = 151/773 (19%), Positives = 325/773 (42%), Gaps = 105/773 (13%)
Query: 25 KLLEDQLSKLKD--------------ERASLQDELREYEERIN---SMTSHFKNVKQELS 67
+ LEDQLS++K +RA LQ E EY +++ ++ S KQ +
Sbjct: 1254 RALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQ--A 1311
Query: 68 ITQSLCKARERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQ 127
TQ + + +R+ E E K+ L + + L + E K++ + + KA
Sbjct: 1312 FTQQI-EELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANS 1370
Query: 128 KLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQ 187
++ + + D LEE+ K + L + A++ + A LE+
Sbjct: 1371 EVAQWRTKYETDAIQRTEELEEAKKKLAQRL---QDAEEHVEAVNAKCASLEKTKQRLQN 1427
Query: 188 KRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALE 247
+ + L ++ T +A LDK ++F KI E ++ ++ +E QK + +
Sbjct: 1428 EVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKESRSLSTELFK 1487
Query: 248 LARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQL 307
+ +E+ ++ +K + K L+ EI + TE +I+ +++ + + E + +L
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTE---QIAEGGKRIHELEKIKKQVEQEKSEL 1544
Query: 308 KGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKT 367
+ L+ +A++ + ++ ++++K ++ + A + + + ++ E + T
Sbjct: 1545 QAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQST 1604
Query: 368 MSVEEKATNLEDMLKEE-EKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGT 426
+ E ++ N LK++ E D+ E+++QLN A + E ++ T
Sbjct: 1605 LDAEIRSRNDAIRLKKKMEGDLNEMEIQLN--------HANRMAAEALRN------YRNT 1650
Query: 427 RSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVE 486
++ LK L + L+ QE + Q + VERR + L+ EI E
Sbjct: 1651 QAILKDTQLHLD----DALRSQEDLKEQ---LAMVERRANLLQAEIE------------E 1691
Query: 487 LRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKE 546
LR +LE+ + + + E ++ + + ++ + K+ L T I+++
Sbjct: 1692 LRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQI---------- 1741
Query: 547 LDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVH 606
+G +D++ E + + K+ AEE+ +K+Q +A ER +K +
Sbjct: 1742 ----QGEMEDIIQEARNAEEKAKKAITDAAMMAEEL-----KKEQDTSAHLER---MKKN 1789
Query: 607 KTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIK 666
+++ E E ++ + ++ +I+KL+ R V L E E E+ + +K
Sbjct: 1790 LEQTVKDLQHRLDEAEQLALKGGKK--QIQKLEAR-----VRELEGEVESEQKRNVEAVK 1842
Query: 667 AAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELK 726
++ E +E L + + K I L++ + L + +YK+ ++
Sbjct: 1843 GLRKHERKVKE---LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEA---------- 1889
Query: 727 IQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQ 779
EEQ K+R Q ++ E +E E+ ++ + + V K+ ++
Sbjct: 1890 ---EEQSNVNLSKFRRIQHELEEAEERADIAESQVNKLRVKSREVHTKIISEE 1939
Score = 99.0 bits (245), Expect = 2e-20
Identities = 148/729 (20%), Positives = 299/729 (41%), Gaps = 89/729 (12%)
Query: 198 ETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETRE 257
E + + E +K ++ K +R+EL E + MQ+++ E +
Sbjct: 852 EMANMKEEFEKTKEELAKTEAKRKELE---EKMVTLMQEKNDLQLQVQAEADSLADAEER 908
Query: 258 KENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKAT 317
+ L+K KI+ LE++I TE + + +L + +D + +LK ++D L+ T
Sbjct: 909 CDQLIKTKIQ-LEAKIKEVTERAEDEEEINAELTAKKRKLEDECS---ELKKDIDDLELT 964
Query: 318 VNRTSSDLEALR---KNISKIKKDIHEETARLQKTKN-----HNEII------QTKLKEI 363
+ + + A KN+++ + E A+L K K H + + + K+ +
Sbjct: 965 LAKVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTL 1024
Query: 364 TEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEI 423
T+ + +E++ +LE L++E+K +++ ++G L K AQE + +K L E
Sbjct: 1025 TKAKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDL-KLAQESTMDIENDKQQLDE- 1082
Query: 424 EGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSE-------E 476
LK ++ L + +Q + I++++ R+ L+ EI +E E
Sbjct: 1083 -----KLKKKEFEMSGLQSKIEDEQALGMQLQKKIKELQARIEELEEEIEAERASRAKAE 1137
Query: 477 KQA--LEAKIVELRKSLEEKKSTCGL-------LETQIKKLHNDLYFIKKAHSKNSDE-K 526
KQ L ++ E+ + LEE E + +K+ DL H + +
Sbjct: 1138 KQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLR 1197
Query: 527 QSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLE 586
+ + EL +++D + KQ L E + +K+E+ + L S E V +
Sbjct: 1198 KKHADSVAELG-------EQIDNLQRVKQKLEKEKSEMKMEI----DDLASNMETVSKAK 1246
Query: 587 KRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILT 646
+++ A+E++ EIK + I + +R + TE E +++ E T
Sbjct: 1247 GNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLD------EKDT 1300
Query: 647 VVMLPPEGEEEKTQAYYVIKAAQEKE---------ELQREGDCLDAKINKAEKEIYALEN 697
+V G++ TQ +K E+E LQ D + E+E A
Sbjct: 1301 LVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAE 1360
Query: 698 TLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSM 757
+ ++ N+ Q K +D + +LEE K+ + ++ + + + + S+
Sbjct: 1361 LQRAMSKANSEVAQWRTKY--ETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASL 1418
Query: 758 ENTLDVIEHLANNVKEKLSEKQAYSFQLSK--------------ETEEQKPKLERVTKQC 803
E T +++ ++ + A L K + EE +LE K+
Sbjct: 1419 EKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKES 1478
Query: 804 AKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRII--LQTYFQ 861
L+ E+ +K+ +E++++ + RE K + I ++ I E I + ++ +
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVE 1538
Query: 862 QSGLELPTA 870
Q EL A
Sbjct: 1539 QEKSELQAA 1547
Score = 99.0 bits (245), Expect = 2e-20
Identities = 164/829 (19%), Positives = 330/829 (39%), Gaps = 141/829 (17%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
L +Q+ L+ + L+ E E + I+ + S+ + V + + +C+A E +
Sbjct: 1207 LGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS----- 1261
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAW 146
E+ ++E QRL N++ + + + + + D L Q++ +QA
Sbjct: 1262 ------EIKTKEEEQQRLINDLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQ 1315
Query: 147 LEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLEL 206
+EE L++ +++ AL L+ +C+ +L + E A+ EL
Sbjct: 1316 IEE----------LKRQLEEEIKAKSALAHALQSSRHDCD----LLREQYEEEQEAKAEL 1361
Query: 207 DKAAQDFRKIHNERQELIKQWENTIE-QMQKRDGDIDNCALELARIKQETREKENLVKEK 265
+A K ++E + QW E +R +++ +LA+ Q+ E V K
Sbjct: 1362 QRAMS---KANSE----VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAK 1414
Query: 266 IKFLESEIGN-NTEFEKRISVADRKLLKCRTA---YQDHETSRIQLKGELDSLKATVNRT 321
LE E E + +R C ++ + + K + + A + +
Sbjct: 1415 CASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEAS 1474
Query: 322 SSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDML 381
+ +L + KIK E +L+ K N+ +Q ++ ++TE+ ++ LE +
Sbjct: 1475 QKESRSLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK 1534
Query: 382 KEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLD 441
K+ E++ E+ L + L + ++ ++ V SE++ +
Sbjct: 1535 KQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAE------------ 1582
Query: 442 FETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLL 501
K +EI + HI+ VE S L EI S + L+K +E L
Sbjct: 1583 ----KDEEIDQMKRNHIRIVESMQSTLDAEIRSRN------DAIRLKKKMEG-----DLN 1627
Query: 502 ETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIE- 560
E +I+ H + + +N Q++ + + L +D + + + K +Q M+E
Sbjct: 1628 EMEIQLNHANRMAAEAL--RNYRNTQAI---LKDTQLHLDDALRSQEDLK--EQLAMVER 1680
Query: 561 -DNLLKLEVKRTREMLHS-------KAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLAS 612
NLL+ E++ R L +E+L +R Q L+T + T I K L +
Sbjct: 1681 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHT---QNTSLINT-KKKLET 1736
Query: 613 QIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKE 672
I + E E+I E R K +K + AA E
Sbjct: 1737 DISQIQGEMEDIIQEARNAEEKAKKA-------------------------ITDAAMMAE 1771
Query: 673 ELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQ 732
EL++E D T L N +Q+ K + DE E ++ L+
Sbjct: 1772 ELKKEQD------------------TSAHLERMKKNLEQTVKDLQHRLDEAE-QLALKGG 1812
Query: 733 KRAVDEKYRYKQRQIRELQEDIQS-MENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEE 791
K+ + + + ++REL+ +++S + ++ ++ L + + K+ E L+ +TEE
Sbjct: 1813 KKQIQK----LEARVRELEGEVESEQKRNVEAVKGLRKH-ERKVKE-------LTYQTEE 1860
Query: 792 QKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDE 840
+ + R+ KL +++ K +E E+ ++ L + ++ ++E
Sbjct: 1861 DRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEE 1909
Score = 97.4 bits (241), Expect = 5e-20
Identities = 122/588 (20%), Positives = 256/588 (43%), Gaps = 61/588 (10%)
Query: 265 KIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSD 324
K+ F + + E EK ++ + K + E R +L+ ++ +L N
Sbjct: 835 KLYFKIKPLLKSAETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQ 894
Query: 325 LEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEE-------KATNL 377
++A +++ D E +L KTK ++ K+KE+TE+ EE K L
Sbjct: 895 VQAEADSLA----DAEERCDQLIKTKIQ---LEAKIKEVTERAEDEEEINAELTAKKRKL 947
Query: 378 EDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQL 437
ED E +KD+ D++L L K K A E + + + E+ ++ ++ T + L L
Sbjct: 948 EDECSELKKDID--DLELTLAKVEKEKHATENKVKNLTEE--MAGLDETIAKLTKEKKAL 1003
Query: 438 QKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKST 497
Q+ +TL +Q E +++ L ++ K LE ++ +L SLE++K
Sbjct: 1004 QEAHQQTLDD----------LQAEEDKVNTL-----TKAKIKLEQQVDDLEGSLEQEKKI 1048
Query: 498 CGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDL 557
LE +KL DL +++ ++KQ L K+ + + + +++ + L
Sbjct: 1049 RMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGMQL 1108
Query: 558 MIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYV 617
+ L+ ++ E + ++ EK++ L +EE +E ++ ++QI +
Sbjct: 1109 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIE-M 1167
Query: 618 DQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQRE 677
+++RE EF++ +E+ ++E + K A V + ++ + LQR
Sbjct: 1168 NKKRE---AEFQKMRRDLEEATLQHEATAATL-------RKKHADSVAELGEQIDNLQRV 1217
Query: 678 GDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVD 737
L+ + ++ + EI L + ++ ++ N ++ + + E+K + EEQ+R ++
Sbjct: 1218 KQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS--EIKTKEEEQQRLIN 1275
Query: 738 EKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLE 797
+ + R E E + ++ ++ L+ KQA++ Q+ EE K +LE
Sbjct: 1276 DLTAQRARLQTESGEYSRQLDEKDTLVSQLSRG-------KQAFTQQI----EELKRQLE 1324
Query: 798 RVTKQCAKLTKEIRLLKD----TKDETMEEQDIKLREMKQFHKVIDEM 841
K + L ++ + +++ EEQ+ K + K E+
Sbjct: 1325 EEIKAKSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEV 1372
Score = 73.6 bits (179), Expect = 8e-13
Identities = 99/459 (21%), Positives = 203/459 (44%), Gaps = 52/459 (11%)
Query: 17 IPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELS-ITQSLCKA 75
+ + +E++ L +L K+K+ D+L ++ KN++QE+S +T+ + +
Sbjct: 1471 LEASQKESRSLSTELFKIKNAYEESLDQL-------ETLKRENKNLQQEISDLTEQIAEG 1523
Query: 76 RERETESEEHFKAIAQR--ELGRVKDEIQ-RLENEMASIL-------EKKSDKENGIFKA 125
+R E E+ K + Q EL +E + LE+E IL + KS+ + I +
Sbjct: 1524 GKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEK 1583
Query: 126 TQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLEC 185
+++D +K +++++ L+ +DA+ L+K + D N++ R+ E
Sbjct: 1584 DEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEA 1643
Query: 186 -----NQKRKILDNE--LTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRD 238
N + + D + L + + +Q +L + + N Q I++ T+EQ ++
Sbjct: 1644 LRNYRNTQAILKDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSR 1703
Query: 239 GDIDNCALELA-RIKQETREKENLVKEKIKFLESEIGN-NTEFEKRISVADRKLLKCRTA 296
+ L+ + R++ + +L+ K K LE++I E E I A K + A
Sbjct: 1704 KIAEQELLDASERVQLLHTQNTSLINTK-KKLETDISQIQGEMEDIIQEARNAEEKAKKA 1762
Query: 297 YQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHE-----ETARLQKTKN 351
D +LK E D TS+ LE ++KN+ + KD+ E L+ K
Sbjct: 1763 ITDAAMMAEELKKEQD--------TSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKK 1814
Query: 352 HNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQL-----NLIKGVLFKKA 406
+ ++ +++E+ + S +++ L++ E+ VKE+ Q N+++ L
Sbjct: 1815 QIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKELTYQTEEDRKNILR--LQDLV 1872
Query: 407 QELQTETMKEKAVLSEIEG----TRSSLKHLNHQLQKLD 441
+LQ + K E E S + + H+L++ +
Sbjct: 1873 DKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAE 1911
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 118 bits (295), Expect = 3e-26
Identities = 176/885 (19%), Positives = 364/885 (41%), Gaps = 123/885 (13%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVK-QELSITQSLCKARER-- 78
+E ++++ K KDE A + + +E EE++ ++ +++ Q S SL A ER
Sbjct: 850 KEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCE 909
Query: 79 -----ETESEEHFKAIAQR--------------------ELGRVKDEIQRLENEMASILE 113
+ + E K + +R E +K +I LE +A + +
Sbjct: 910 QLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 969
Query: 114 KKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRA 173
+K EN + T+++ GL D+ + E+ A +++ TL Q +++K+
Sbjct: 970 EKHATENKVKNLTEEMAGL------DETIAKLSKEKKALQETHQQTLDD-LQAEEDKVNI 1022
Query: 174 LTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQ 233
LT +L + + L+ E + + K D + ++ + E+
Sbjct: 1023 LTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK 1082
Query: 234 MQKRDGDIDNCALELARIKQETREKENLVKEKIKFLES---EIGNNTEFEKRISVADRKL 290
++K++ +I N +++I+ E + E +++KIK L++ E+G E E +
Sbjct: 1083 LEKKEFEISNL---ISKIEDE-QAVEIQLQKKIKELQARIEELGEEIEAE--------RA 1130
Query: 291 LKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRK---NISKIKKDIHEET---- 343
+ + Q + SR +L+ + L+ TS+ +E +K K+++D+ E T
Sbjct: 1131 SRAKAEKQRSDLSR-ELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189
Query: 344 ARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLF 403
A + + + +L E + V++K + LK E D+ ++ KG L
Sbjct: 1190 AMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLE 1249
Query: 404 KKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVER 463
K + L+ + + K ++ E + + L Q +L E + + +D + Q+ R
Sbjct: 1250 KMCRSLEDQVSELK---TKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSR 1306
Query: 464 RMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNS 523
KQA +I EL+ LEE+ L ++ +D +++ + +
Sbjct: 1307 ------------SKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQ 1354
Query: 524 DEKQSLMTKINELNLFID--RSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEE 581
+ K L +++ N + R++ E D + ++L L ++ E + + +
Sbjct: 1355 EGKAELQRALSKANSEVAQWRTKYETDAIQR-TEELEEAKKKLAQRLQEAEEHVEAVNAK 1413
Query: 582 VLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNR 641
SLEK KQ+L +E+ +++ A+ +D+++ N + + K +
Sbjct: 1414 CASLEKTKQRLQNEVEDLMLDVERSNAACAA----LDKKQRNFD-------KVLSEWKQK 1462
Query: 642 YEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQV 701
Y E+TQA E E Q+E L ++ K + + L+
Sbjct: 1463 Y--------------EETQA--------ELEASQKESRSLSTELFKVKNVYEESLDQLET 1500
Query: 702 LNSCNNNYKQSFKKVTPSSDEYELKI-QLEEQKRAVDEKYRYKQRQIRELQEDIQSMENT 760
L N N +Q +T E +I +LE+ K+ V+++ Q + E + ++ E
Sbjct: 1501 LRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGK 1560
Query: 761 LDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDET 820
+ I+ N VK ++ K A E +E+ +L+R T+ + ++ T D
Sbjct: 1561 ILRIQLELNQVKSEVDRKIA-------EKDEEIDQLKR------NHTRVVETMQSTLDAE 1607
Query: 821 MEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQSGL 865
+ ++ LR K+ ++EM + + N L+ Y G+
Sbjct: 1608 IRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAESLRNYRNTQGI 1652
Score = 113 bits (282), Expect = 1e-24
Identities = 177/912 (19%), Positives = 392/912 (42%), Gaps = 149/912 (16%)
Query: 23 ENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELS-ITQSLCK-ARERET 80
+ + LED+ S+LK + L+ L + E+ ++ + KN+ +E++ + +++ K ++E++
Sbjct: 942 KKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKA 1001
Query: 81 ESEEHFKAIAQRE--------LGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDG- 131
E H + + + L + K ++++ +++ LE++ + +A +KL+G
Sbjct: 1002 LQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGD 1061
Query: 132 LKC------QMNWDQQALEAWLEESAHKDSDALTLQKYAQ----QDDNKIRALTLQLERL 181
LK M D+Q L+ LE+ + S+ ++ + Q Q KI+ L ++E L
Sbjct: 1062 LKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEEL 1121
Query: 182 TLE----------CNQKRKILDNELTE----------TISAQLELDKAAQ-DFRKIHNER 220
E ++R L EL E SAQ+EL+K + +F+K+ +
Sbjct: 1122 GEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDL 1181
Query: 221 QELIKQWENTIEQMQKRDGD--------IDNCALELARIKQETREKENLVKEKIKFLESE 272
+E Q E + ++K+ D IDN L R+KQ+ EKE K ++K +
Sbjct: 1182 EEATLQHEAMVAALRKKHADSMAELGEQIDN----LQRVKQKL-EKE---KSELKMETDD 1233
Query: 273 IGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNI 332
+ +N E IS A L K + +D + +LK + + + +N ++ L+
Sbjct: 1234 LSSNAE---AISKAKGNLEKMCRSLEDQVS---ELKTKEEEQQRLINDLTAQRARLQTEA 1287
Query: 333 SKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLE-----------DML 381
+ + + E+ A + + + +++E+ + + E KA N D+L
Sbjct: 1288 GEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQ-LEEETKAKNALAHALQSSRHDCDLL 1346
Query: 382 KEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLD 441
+E+ ++ +E +L + + ++ Q T E + E + K L +LQ+ +
Sbjct: 1347 REQYEEEQEGKAELQ--RALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAE 1404
Query: 442 FETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLL 501
H++ V + + L+ + KQ L+ ++ +L +E + C L
Sbjct: 1405 E--------------HVEAVNAKCASLE-----KTKQRLQNEVEDLMLDVERSNAACAAL 1445
Query: 502 ETQIKKLHNDLYFIKKAHSK-------NSDEKQSLMTKINELNLFIDRSEKELDKAKGFK 554
+ + + L K+ + + + E +SL T++ ++ + S +L+ +
Sbjct: 1446 DKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRREN 1505
Query: 555 QDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQI 614
++L E + L ++ + +H + +E+ K ++ A+EE ++ + +
Sbjct: 1506 KNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQ 1565
Query: 615 RYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEEL 674
++Q + + + E+ +I++LK + + M E +++ A + K+++
Sbjct: 1566 LELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRN----DALRVKKKM 1621
Query: 675 QREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQ--LEEQ 732
+ + + ++ ++N A N L + N Q K T + L+ Q L+EQ
Sbjct: 1622 EGDLNEMEIQLNHA--------NRLAAESLRNYRNTQGILKETQLHLDDALRGQEDLKEQ 1673
Query: 733 KRAVDEKYRYKQRQIRELQEDIQSMENTLDVIE-------------HLAN----NVKEKL 775
V+ + Q +I EL ++ E + + E H N N K+KL
Sbjct: 1674 LAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKL 1733
Query: 776 ----SEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTK----------DETM 821
S+ Q+ ++ +E+ + K ++ A + +E++ +DT ++T+
Sbjct: 1734 ENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTV 1793
Query: 822 EEQDIKLREMKQ 833
++ +L E +Q
Sbjct: 1794 KDLQHRLDEAEQ 1805
Score = 98.6 bits (244), Expect = 2e-20
Identities = 126/630 (20%), Positives = 263/630 (41%), Gaps = 67/630 (10%)
Query: 265 KIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSD 324
K+ F + + E EK ++ + K + E R EL+ T+ + +D
Sbjct: 834 KLFFKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKR----KELEEKMVTLLKEKND 889
Query: 325 LEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEE-------KATNL 377
L+ ++ + D E +L K K ++ K+KE+TE+ EE K L
Sbjct: 890 LQLQVQSEADSLADAEERCEQLIKNKIQ---LEAKIKEVTERAEEEEEINAELTAKKRKL 946
Query: 378 EDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQL 437
ED E +KD+ D++L L K K A E + + + E+ ++ ++ T + L L
Sbjct: 947 EDECSELKKDID--DLELTLAKVEKEKHATENKVKNLTEE--MAGLDETIAKLSKEKKAL 1002
Query: 438 QKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKST 497
Q+ +TL ++ +D K I ++ K LE ++ +L SLE++K
Sbjct: 1003 QETHQQTL--DDLQAEED-------------KVNILTKAKTKLEQQVDDLEGSLEQEKKL 1047
Query: 498 CGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDL 557
LE +KL DL +++ ++KQ L K+ + I +++ + + L
Sbjct: 1048 RMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQL 1107
Query: 558 MIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYV 617
+ L+ ++ E + ++ EK++ L +EE +E ++ ++Q+ +
Sbjct: 1108 QKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVE-L 1166
Query: 618 DQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQRE 677
+++RE EF++ +E+ ++E + + K A + + ++ + LQR
Sbjct: 1167 NKKRE---AEFQKLRRDLEEATLQHEAMVAAL-------RKKHADSMAELGEQIDNLQRV 1216
Query: 678 GDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVD 737
L+ + ++ + E L + + ++ N ++ + + ELK + EEQ+R ++
Sbjct: 1217 KQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMCRSL--EDQVSELKTKEEEQQRLIN 1274
Query: 738 EKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLE 797
+ + R ++ A +L EK A QLS+ + ++E
Sbjct: 1275 DLTAQRAR------------------LQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIE 1316
Query: 798 RVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEI---RI 854
+ Q + TK L + + D+ + ++ + E+ + + N+E+ R
Sbjct: 1317 ELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRT 1376
Query: 855 ILQTYFQQSGLELPTASTKGSRQSSRSPSH 884
+T Q EL A K +++ + H
Sbjct: 1377 KYETDAIQRTEELEEAKKKLAQRLQEAEEH 1406
Score = 94.7 bits (234), Expect = 3e-19
Identities = 166/823 (20%), Positives = 332/823 (40%), Gaps = 98/823 (11%)
Query: 32 SKLKDERASLQDELREYEERIN----SMTSHFKNVKQELSITQSLCKARERETESEEHFK 87
+K + +R+ L EL E ER+ + ++ + K+ + Q L + E T E
Sbjct: 1133 AKAEKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV 1192
Query: 88 AIAQR-------ELG-------RVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLK 133
A ++ ELG RVK ++++ ++E+ + S I KA L+ +
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKM- 1251
Query: 134 CQMNWDQQALEAWLEESAHKDSDALTLQK---------YAQQDDNKIRALTLQLERLTLE 184
C+ DQ + EE + + LT Q+ Y++Q D K AL QL R
Sbjct: 1252 CRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEK-DALVSQLSRSKQA 1310
Query: 185 CNQKRKILDNELTETISAQLELDKAAQD-------FRKIHNERQE--------------L 223
Q+ + L ++L E A+ L A Q R+ + E QE
Sbjct: 1311 STQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSE 1370
Query: 224 IKQWENTIE-QMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGN-NTEFEK 281
+ QW E +R +++ +LA+ QE E V K LE E E
Sbjct: 1371 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVED 1430
Query: 282 RISVADRKLLKCRTA---YQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKD 338
+ +R C ++ + + K + + +A + + + +L + K+K
Sbjct: 1431 LMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNV 1490
Query: 339 IHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLI 398
E +L+ + N+ +Q ++ ++TE+ ++ LE + K+ E++ E+ L
Sbjct: 1491 YEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEA 1550
Query: 399 KGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHI 458
+ L + ++ ++ V SE++ + QL++ ++ + +
Sbjct: 1551 EASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRS 1610
Query: 459 QQVERRM-SRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLL-ETQI---------KK 507
+ R+ +++G++N E Q A + +SL ++T G+L ETQ+ +
Sbjct: 1611 RNDALRVKKKMEGDLNEMEIQLNHANRL-AAESLRNYRNTQGILKETQLHLDDALRGQED 1669
Query: 508 LHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLL--- 564
L L +++ + E + L + + +E+EL A Q L ++ L
Sbjct: 1670 LKEQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINT 1729
Query: 565 KLEVKRTREMLHSKAEEVL----SLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQE 620
K +++ L S+ EEV+ + E++ ++ T EE+K + ++ + + +
Sbjct: 1730 KKKLENDVSQLQSEVEEVIQESRNAEEKAKKAITDAAMMAEELKKEQD-TSAHLERMKKN 1788
Query: 621 RENISTEFRERLSKIEKL-----KNRYEILTVVMLPPEGEEEKTQA--YYVIKAAQEKEE 673
E + + RL + E+L K + + L + EGE E Q +K ++ E
Sbjct: 1789 LEQTVKDLQHRLDEAEQLALKGGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHER 1848
Query: 674 LQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQK 733
+E L + + K + L++ + L + +YK+ + + EEQ
Sbjct: 1849 RVKE---LTYQTEEDRKNVLRLQDLVDKLQAKVKSYKRQAE-------------EAEEQS 1892
Query: 734 RAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLS 776
A K+R Q ++ E +E E+ ++ + + V K+S
Sbjct: 1893 NANLSKFRKLQHELEEAEERADIAESQVNKLRVKSREVHTKIS 1935
Score = 35.8 bits (81), Expect = 0.19
Identities = 46/229 (20%), Positives = 102/229 (44%), Gaps = 34/229 (14%)
Query: 25 KLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEE 84
K LE+ +S+L+ E + E R EE+ K+ ++ + + ++E ++
Sbjct: 1731 KKLENDVSQLQSEVEEVIQESRNAEEK----------AKKAITDAAMMAEELKKEQDTSA 1780
Query: 85 HFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALE 144
H + + + VKD RL+ A L K K K QKL+ + LE
Sbjct: 1781 HLERMKKNLEQTVKDLQHRLDE--AEQLALKGGK-----KQIQKLEA-------RVRELE 1826
Query: 145 AWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQL 204
+E ++++A+ K ++ + +++ LT Q E ++K + +L + + A++
Sbjct: 1827 GEVENEQKRNAEAV---KGLRKHERRVKELTYQTEE-----DRKNVLRLQDLVDKLQAKV 1878
Query: 205 E-LDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIK 252
+ + A++ + N ++ ++ +E+ ++R DI + R+K
Sbjct: 1879 KSYKRQAEEAEEQSNANLSKFRKLQHELEEAEER-ADIAESQVNKLRVK 1926
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 117 bits (292), Expect = 7e-26
Identities = 187/918 (20%), Positives = 381/918 (41%), Gaps = 139/918 (15%)
Query: 31 LSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHFKAIA 90
++++K + ++ E E E +++S TS +E+ Q + E ES K ++
Sbjct: 1304 VAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIES---LKTVS 1360
Query: 91 QRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAWLEES 150
+ Q+LE+ I + +E KLD L+ ++ ++ + +
Sbjct: 1361 HEAEVHAESLQQKLESSQLQIAGLEHLRE-----LQPKLDELQKLISKKEEDVSYLSGQL 1415
Query: 151 AHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAA 210
+ K++ +Q + ++ I+AL QLE E +++ K L EL E E+ + +
Sbjct: 1416 SEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEES 1475
Query: 211 QDFRKIHNE-------RQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVK 263
+ ++I + R+E +K+ ++ E++ G I+ LA ++ + + K
Sbjct: 1476 RAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQN---K 1532
Query: 264 EKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKG----------ELDS 313
EK L E +K I+ DR LL+ ++ E+ ++ L+G E++S
Sbjct: 1533 EKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKEKLVKEIES 1592
Query: 314 LKATVNRTSSDLEALRKNISK-------IKKDIHEETARLQKTKNHNEIIQTKLKEITEK 366
LK++ S++ + K + K +++ E R+Q E ++ + +E+ K
Sbjct: 1593 LKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVV---EAVRQEKQELYGK 1649
Query: 367 TMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSE---- 422
S E E L+E E++++E+ ++ +K EL+ E + +A +
Sbjct: 1650 LRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDT 1709
Query: 423 ----IEGTRSSLKHLNHQLQ--KLDFETL--KQQEIMYSQDFHIQQVERRMSRLKGEINS 474
+E SS + +L+ K+++ETL K Q +M +D ++V+ +++G ++
Sbjct: 1710 AKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK 1769
Query: 475 EEK-QALEAKIVELRKSLEEKKSTCGLLETQ----IKKLHNDLYFIKKAHSKNS------ 523
+ +A E + + E +S G E Q + + A S N
Sbjct: 1770 QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDF 1829
Query: 524 ---DEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAE 580
DE + + +I++L I E+E K K F Q L E N L ++ L E
Sbjct: 1830 SSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQE 1889
Query: 581 EVLSLEKRKQQL------YTAMEERTEEIK-----------------------------V 605
EV + QQ+ T ++E EE K +
Sbjct: 1890 EVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQI 1949
Query: 606 HKTMLASQIRYVDQERENISTEFRERLSKIEKLKN--RYEILTVVMLPPEGEEEKTQAYY 663
+L S+++ + + + E ++ + + K+++ R E L + + K+ A
Sbjct: 1950 KNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKE 2009
Query: 664 VIKAAQEKEE--LQREGDCL--DAKINKAEKEIYALE----NTLQVLNSCNNNYKQ---- 711
+ + +EK++ Q + DC+ KI+ E+ + ALE + + L N Q
Sbjct: 2010 LQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEH 2069
Query: 712 ---------SFKKVTPS---------SDEYELKIQLEEQKRAVDEKYRYK----QRQIRE 749
SFK + +D +LK +L+ K +V + + K +R++ +
Sbjct: 2070 RKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQ 2129
Query: 750 LQE----DIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAK 805
+E + ++M+ LD + +++E + E Q + KE ++ + L+ Q A
Sbjct: 2130 AEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAA 2189
Query: 806 LTKEIRLLKDTKDETMEE 823
TK + L+D +D ++E
Sbjct: 2190 FTKSMSSLQDDRDRVIDE 2207
Score = 117 bits (292), Expect = 7e-26
Identities = 174/845 (20%), Positives = 361/845 (42%), Gaps = 118/845 (13%)
Query: 25 KLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQS-LCKARERETESE 83
K L++ L + + E LQ + Y+E+I+++ K ++ + +Q L +E ++
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067
Query: 84 EHFKAIAQRELGRVKDEIQRLENEMASIL--------EKKSDKENGIFKATQKLDGLKCQ 135
EH K AQ EL K + ++E A +L E +S+KE+ + QK + L+ +
Sbjct: 2068 EHRKK-AQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR 2126
Query: 136 MNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNE 195
+ +QA E L+E + L++ + I + + L + E Q ++ LD+
Sbjct: 2127 L---EQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDST 2183
Query: 196 LTETISAQLELDKAAQDFRKIHNERQELIKQWENTI-EQMQKRDGDI----DNCALELAR 250
+T+ + + D ++ +E K+WE + +Q ++ +I DNC++ +
Sbjct: 2184 VTQLAAFTKSMSSLQDDRDRVIDEA----KKWERKFSDAIQSKEEEIRLKEDNCSVLKDQ 2239
Query: 251 IKQETREKENLVKEKIKFLES-----EIGNNTEFEKRISVADR----------KLLKCRT 295
++Q + E L K I LE E TE + + V D +L + R
Sbjct: 2240 LRQMSIHMEEL-KINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRH 2298
Query: 296 AYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEI 355
Y + +L+ EL SLK + S+ LE ++ ++ I ++ A +Q +K E
Sbjct: 2299 LYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQ 2358
Query: 356 IQTKLKEITEKTMSVEE----KATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQT 411
++T L+ E T + E K + +L +E+ ++ +L K+ + L +
Sbjct: 2359 LETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418
Query: 412 ETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGE 471
+ +E VL E + ++ N ++ L +T+K++ I Q + + MS L+ +
Sbjct: 2419 QEEEENIVLEE--ENKKAVDKTNQLMETL--KTIKKENIQ--QKAQLDSFVKSMSSLQND 2472
Query: 472 INSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNS---DEKQS 528
+ +IV + LEE+ + L + Q+ I++A ++N+ +E +
Sbjct: 2473 RD---------RIVGDYQQLEERHLSIILEKDQL---------IQEAAAENNKLKEEIRG 2514
Query: 529 LMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKR 588
L + +++LN + + EL + +++DL + ++ ++ + +++L + ++ LE +
Sbjct: 2515 LRSHMDDLNSENAKLDAELIQ---YREDL---NQVITIKDSQQKQLLEVQLQQNKELENK 2568
Query: 589 KQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVV 648
Y +EE+ +E + L + +E++++S E I +L + L
Sbjct: 2569 ----YAKLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTAL--- 2621
Query: 649 MLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNN 708
+EE T Y + ++EE+ R L A + ++K I LE L +
Sbjct: 2622 ------QEEGTLGLYHAQLKVKEEEVHR----LSALFSSSQKRIAELEEELVCVQ----- 2666
Query: 709 YKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLA 768
K++ KKV D+ + ++++ L D M N + E
Sbjct: 2667 -KEAAKKVGEIEDKLK--------------------KELKHLHHDAGIMRNETETAEERV 2705
Query: 769 NNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKL 828
+ L E + ++KE + +++ + + L + DE + D L
Sbjct: 2706 AELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASL 2765
Query: 829 REMKQ 833
+E+ Q
Sbjct: 2766 KELAQ 2770
Score = 116 bits (291), Expect = 9e-26
Identities = 195/978 (19%), Positives = 393/978 (40%), Gaps = 161/978 (16%)
Query: 11 WEDGF--AIPVANEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNV-----K 63
WE F AI EE +L ED S LKD+ + + E + I S H K + +
Sbjct: 2211 WERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINI-SRLEHDKQIWESKAQ 2269
Query: 64 QELSITQSLCKARERET-------ESEEHFKAIAQRELGRVKDEIQRLENEMAS------ 110
E+ + Q +C + E E H +Q EL +++ E++ L++++
Sbjct: 2270 TEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLE 2329
Query: 111 ------------ILEKKSDKENGIFKATQKLDGLKC----------QMNWDQQALEAWLE 148
I ++++D +N F Q L+ ++N +Q + + L
Sbjct: 2330 KCKEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLL- 2388
Query: 149 ESAHKDSDALTLQKYAQQDDNKIRALTLQL-----ERLTLECNQKRKI-LDNELTET--- 199
S +++ + + + QQ D +I+ L L E + LE K+ + N+L ET
Sbjct: 2389 -SGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKT 2447
Query: 200 -----ISAQLELDKAAQDFRKIHNERQELIKQWENTIEQ----MQKRDGDIDNCALELAR 250
I + +LD + + N+R ++ ++ E+ + ++D I A E +
Sbjct: 2448 IKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNK 2507
Query: 251 IKQETR-----------EKENLVKEKIKF------------------LESEIGNNTEFEK 281
+K+E R E L E I++ LE ++ N E E
Sbjct: 2508 LKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELEN 2567
Query: 282 RISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHE 341
+ + + KL + A +D L+ ++L+ S ++E+L+ +IS++ + +
Sbjct: 2568 KYAKLEEKLKESEEANED-------LRRSFNALQEEKQDLSKEIESLKVSISQLTRQV-- 2618
Query: 342 ETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGV 401
TA ++ Q K+K EE+ L + +K + E++ +L ++
Sbjct: 2619 -TALQEEGTLGLYHAQLKVK---------EEEVHRLSALFSSSQKRIAELEEELVCVQKE 2668
Query: 402 LFKKAQELQTETMKEKAVLSEIEG-TRSSLKHLNHQLQKL--DFETLKQQEIMYSQD--- 455
KK E++ + KE L G R+ + ++ +L D ++Q+ +M +++
Sbjct: 2669 AAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLMVTKENKG 2728
Query: 456 --FHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLY 513
IQ R MS L+ + ++ E K RK K L E + D
Sbjct: 2729 LTAQIQSFGRSMSSLQNSRDHANEELDELK----RKYDASLKELAQLKEQGLLNRERDAL 2784
Query: 514 FIKKAHSKNSDEKQSL--MTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRT 571
+ A S NS E+ SL + K+N+ L D L + + + ++
Sbjct: 2785 LSETAFSMNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNE 2844
Query: 572 REMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRER 631
R+ L ++ E+ E+ KQ+ E++ K ++S + +R+ + E +
Sbjct: 2845 RDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSS----LQNDRDRLLKELKNL 2900
Query: 632 LSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKE 691
+ ++ L + + ++KT+A+ +++ +E L + + ++ K+ E
Sbjct: 2901 QQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWE 2960
Query: 692 IYALENTLQVLNSCNNNYKQ------SFKKVTPSSDEYE-LKIQLEEQKRAV-------D 737
I+ Q L + ++ +Q +++ SS + + LK+Q + Q
Sbjct: 2961 IHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGS 3020
Query: 738 EKYRYKQRQIR-ELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQL---SKETEEQK 793
+ Y+ +R +L + ++ + I+ L +N + L EK S QL S+ E +
Sbjct: 3021 QNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQ 3080
Query: 794 PKLERVTKQCAKLTKEIRLLK------DTKDETMEEQD--------IKLREMKQFHKVID 839
+ CA L K+++ L+ D +E++ +LRE +Q
Sbjct: 3081 QHYGDLLNHCAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQ 3140
Query: 840 EMLVDIIEENTEIRIILQ 857
+ L + +E E+R +L+
Sbjct: 3141 QQLCNTRQEVNELRKLLE 3158
Score = 105 bits (261), Expect = 3e-22
Identities = 186/902 (20%), Positives = 377/902 (41%), Gaps = 119/902 (13%)
Query: 27 LEDQLSKLKDE-----------RASLQDELREYEERINSMTSHFKNVKQELSITQSLCKA 75
LE++L+ LKDE R ++++ E +TS + ++ L T S
Sbjct: 1012 LEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTIS---- 1067
Query: 76 RERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQ 135
E+E E + H + + +L +++ Q L +M L+ K T ++D L+ +
Sbjct: 1068 -EKEVELQ-HIRKDLEEKLA-AEEQFQALVKQMNQTLQDK----------TNQIDLLQAE 1114
Query: 136 MNWDQQALEAWLEESAH-KDSDALTLQK----YAQQDDNKIRALTLQLERLTLECNQKRK 190
++ +Q ++ + + D D++ L K + +LE L ++++
Sbjct: 1115 ISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKE 1174
Query: 191 ILDNELTETISAQLELDKAAQDFRKIHNERQELIKQ---WENTIEQMQKRDGDIDNCALE 247
L +L E ++++ + K AQ+ K + R+EL +Q + EQ ++ + +N +
Sbjct: 1175 QLQKKLQEALTSRKAILKKAQE--KERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQ 1232
Query: 248 LARIKQETREK---------ENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQ 298
L +++ + RE + LE + TE V + L ++
Sbjct: 1233 LRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHS 1292
Query: 299 DHE------TSRIQLKGELDSLKAT-------VNRTSSDLEALRKNISKIKKDIHEETAR 345
+ TS Q+K +L ++A V+ T+S+L + + ++++ I+++
Sbjct: 1293 EDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLE 1352
Query: 346 LQKTKN-------HNEIIQTKLKEIT------EKTMSVEEKATNLEDMLKEEEKDVKEVD 392
++ K H E +Q KL+ E ++ K L+ ++ ++E+DV +
Sbjct: 1353 IESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLS 1412
Query: 393 VQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMY 452
QL+ + L K +QTE ++++ ++ + T+ ++ H E +KQ ++
Sbjct: 1413 GQLSEKEAALTK----IQTEIIEQEDLIKALH-TQLEMQAKEHD------ERIKQLQVEL 1461
Query: 453 SQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKST---CGLLETQIKKLH 509
+ + SR K +I ++ L+A ++ +++L+E KS L I++L
Sbjct: 1462 CEMKQKPEEIGEESRAKQQI----QRKLQAALISRKEALKENKSLQEELSLARGTIERLT 1517
Query: 510 NDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVK 569
L ++ S + EK +++ ++ L D+ E+D++ Q L LKL ++
Sbjct: 1518 KSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALE 1577
Query: 570 RTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENI----- 624
E +E+ SL+ K T +E+ +E++ +L V E E I
Sbjct: 1578 GLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE 1637
Query: 625 -----STEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEK-EELQREG 678
E +L E K E + E EE K + K+ Q+K EL+ E
Sbjct: 1638 AVRQEKQELYGKLRSTEANKKETE-KQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEEN 1696
Query: 679 DCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQ-LEEQKRAVD 737
D L A+++ A + ++ L S N + K+ ++V + K Q L +K ++
Sbjct: 1697 DRLRAEVHPAGD---TAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLS 1753
Query: 738 EKYRYKQRQIR---ELQEDIQSME---NTLDVIEHLANNVKEKLSEKQAYSFQLSKETEE 791
E+ + + QI Q ++++ E N +V E ++ + E+ + S E
Sbjct: 1754 EEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSE 1813
Query: 792 QKPKLERVTKQCAK---LTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEE 848
P + +K EI D+ ++E+ L E KQ +K + L + E+
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQIDQ-LKERIAGLEEEKQKNKEFSQTLEN--EK 1870
Query: 849 NT 850
NT
Sbjct: 1871 NT 1872
Score = 99.4 bits (246), Expect = 1e-20
Identities = 195/932 (20%), Positives = 378/932 (40%), Gaps = 143/932 (15%)
Query: 23 ENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVK------QELSITQSLCKAR 76
E + L + L E+ SL +E+++ + +I S N++ + ++T+ ++
Sbjct: 1734 EYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTEEGTQSI 1793
Query: 77 ERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQM 136
ETE ++ +++ + + ++ ++ K + I Q++D LK ++
Sbjct: 1794 PGETEEQD---SLSMSTRPTCSESVPSAKSANPAV-SKDFSSHDEINNYLQQIDQLKERI 1849
Query: 137 NWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNEL 196
++ + E S +++ TL D +++ L ++ ++ L L+ ++
Sbjct: 1850 AGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNL--------LNQQI 1901
Query: 197 TETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALEL--ARIKQE 254
E +S +L + A++ E+ +L E + Q+ + +G I N ++ A+IK E
Sbjct: 1902 QEELSRVTKLKETAEE------EKDDLE---ERLMNQLAELNGSIGNYCQDVTDAQIKNE 1952
Query: 255 T----------------REKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQ 298
EK+ LVKEK K +ESEI E+ ++I A ++ A +
Sbjct: 1953 LLESEMKNLKKCVSELEEEKQQLVKEKTK-VESEI--RKEYLEKIQGAQKEPGNKSHAKE 2009
Query: 299 DHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIK-------KDIHEETARLQKTKN 351
E + + + E+ L+ R + AL + + ++ KD+ L +
Sbjct: 2010 LQELLK-EKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVE 2068
Query: 352 HNEIIQTKL---KEITEKTMSVEEKATNLEDMLK---EEEKDVKEVDVQLNLIKGVLFKK 405
H + Q +L K + + T S E A L D LK E + + + V Q+ L ++
Sbjct: 2069 HRKKAQAELASFKVLLDDTQS--EAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERR 2126
Query: 406 AQELQTETMKEKAVLSE-IEGTRSSLKHLNHQ-------LQKLDFETLKQQEIMYSQDFH 457
++ + + +KEK + E ++ R HL L K D E + QE + S
Sbjct: 2127 LEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQ 2186
Query: 458 IQQVERRMSRLKGEINS--EEKQALEAKIVELRKSLEE----KKSTCGLLETQIKKLHND 511
+ + MS L+ + + +E + E K + +S EE K+ C +L+ Q++++
Sbjct: 2187 LAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIH 2246
Query: 512 LYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRT 571
+ +K S+ +KQ +K + +K D +G ++L+ + ++ T
Sbjct: 2247 MEELKINISRLEHDKQIWESKAQTE---VQLQQKVCDTLQGENKELLSQ-------LEET 2296
Query: 572 REMLHSKAEEVLSLEKRKQQL---YTAMEERTEEIKVHKTMLASQIRYVDQERENISTEF 628
R + HS E+ LE + L T + E+ K K L IR + + +N +
Sbjct: 2297 RHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSY 2356
Query: 629 ----------RERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEEL---- 674
RE S++ + N E + +L G+EE Q Q +E+
Sbjct: 2357 EQLETDLQASRELTSRLHEEINMKEQKIISLL--SGKEEAIQVAIAELRQQHDKEIKELE 2414
Query: 675 ------QREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYK---QSFKKVTPSS----- 720
+ E L+ + KA + L TL+ + N K SF K S
Sbjct: 2415 NLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRD 2474
Query: 721 ---------DEYELKIQLE-----EQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVI-- 764
+E L I LE ++ A + K + + R +R +D+ S LD
Sbjct: 2475 RIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELI 2534
Query: 765 ---EHLANNVKEKLSE-KQAYSFQL--SKETEEQKPKLERVTKQCAKLTKEIRLLKDTKD 818
E L + K S+ KQ QL +KE E + KLE K+ + +++R +
Sbjct: 2535 QYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNALQ 2594
Query: 819 ETMEEQDIKLREMKQFHKVIDEMLVDIIEENT 850
E ++ ++ +K + + + EE T
Sbjct: 2595 EEKQDLSKEIESLKVSISQLTRQVTALQEEGT 2626
Score = 95.5 bits (236), Expect = 2e-19
Identities = 177/925 (19%), Positives = 398/925 (43%), Gaps = 172/925 (18%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERETESEEHF 86
LE++ +L+ E D +E E + S + K + + + E ET S++
Sbjct: 1692 LEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKM--------EYETLSKKFQ 1743
Query: 87 KAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQALEAW 146
+++++ + +E+Q L++++ + K+++ E AT+K D Q N ++ ++
Sbjct: 1744 SLMSEKD--SLSEEVQDLKHQIEGNVSKQANLE-----ATEKHDN---QTNVTEEGTQSI 1793
Query: 147 LEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILD--NELTETISAQL 204
E+ +DS +++ + + ++ + + ++ L ++L E I+
Sbjct: 1794 PGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIAGLE 1853
Query: 205 ELDKAAQDFRK-IHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVK 263
E + ++F + + NE+ L+ Q + +DG++ ++ QE K NL+
Sbjct: 1854 EEKQKNKEFSQTLENEKNTLLSQ-------ISTKDGEL--------KMLQEEVTKMNLLN 1898
Query: 264 EKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSS 323
++I + E+ T+ ++ TA ++ + +L +L L ++
Sbjct: 1899 QQI---QEELSRVTKLKE-------------TAEEEKDDLEERLMNQLAELNGSIGNYCQ 1942
Query: 324 D----------LEALRKNISKIKKDIHEETARL--QKTKNHNEIIQTKLKEI--TEKTMS 369
D LE+ KN+ K ++ EE +L +KTK +EI + L++I +K
Sbjct: 1943 DVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPG 2002
Query: 370 VEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSS 429
+ A L+++LKE++++VK+ LQ + ++ + +S +E T +
Sbjct: 2003 NKSHAKELQELLKEKQQEVKQ------------------LQKDCIRYQEKISALERTVKA 2044
Query: 430 LKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALE--AKIVEL 487
L+ + + QK D E K+ + H ++ + ++ K ++ + +A A ++L
Sbjct: 2045 LEFVQTESQK-DLEITKENLAQAVE--HRKKAQAELASFKVLLDDTQSEAARVLADNLKL 2101
Query: 488 RKSLEEKKSTCGLLETQIKKLHNDLYF-IKKAHSKNSDEKQSLMTKINELNLFIDRSEKE 546
+K L+ K + +++Q+K+ DL +++A K+ EK+++ K++ L R +
Sbjct: 2102 KKELQSNKES---VKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALR----REKVH 2154
Query: 547 LDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYT------------ 594
L++ G ++ + N EV++ +E L S ++ + K L
Sbjct: 2155 LEETIG---EIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKW 2211
Query: 595 ------AMEERTEEIKVHK---TMLASQIR----YVDQERENISTEFRERLSKIEKLKNR 641
A++ + EEI++ + ++L Q+R ++++ + NIS ++ K +
Sbjct: 2212 ERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTE 2271
Query: 642 YEILTVVMLPPEGEE-------EKTQAYY------VIKAAQEKEELQREGDCLDAKINKA 688
++ V +GE E+T+ Y + K E + L+ + L + K
Sbjct: 2272 VQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKC 2331
Query: 689 EKEIYALENTLQVLNSCNNNYKQSFKKV-TPSSDEYEL------KIQLEEQKR------- 734
+++ LE ++ + N K S++++ T EL +I ++EQK
Sbjct: 2332 KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGK 2391
Query: 735 ------AVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKE 788
A+ E + ++I+EL+ + E V+E +K ++ + KE
Sbjct: 2392 EEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKE 2451
Query: 789 TEEQKPKLERVTKQCAKLTKEI-RLLKD-------------TKDETMEEQDIKLREMKQF 834
+QK +L+ K + L + R++ D KD+ ++E + ++K+
Sbjct: 2452 NIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEE 2511
Query: 835 HKVIDEMLVDIIEENTEIRIILQTY 859
+ + + D+ EN ++ L Y
Sbjct: 2512 IRGLRSHMDDLNSENAKLDAELIQY 2536
Score = 87.4 bits (215), Expect = 6e-17
Identities = 177/927 (19%), Positives = 384/927 (41%), Gaps = 143/927 (15%)
Query: 17 IPVANEENKLLEDQLSKLKDERASLQDE-----------LREYEERINSMTSHFKNVKQE 65
+ A + N++L QL +++ E +L++ L + E + F N+++E
Sbjct: 282 LTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQEE 341
Query: 66 LS-ITQSLCKARERETESEEHFKAIAQRELGRVKDEI----------QRLENEMASILEK 114
+ + + +A + + E E + A+ Q+ ++++ Q L++ ++ ++
Sbjct: 342 MHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQ 401
Query: 115 KS----DKENGIFKATQKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNK 170
S DK ++ Q + L+ Q+ + + +L + + + + +
Sbjct: 402 NSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEG 461
Query: 171 IRALTLQLERLTLECNQKRKI-LDNELTETISAQLELDKAAQDFRKIHNERQELIKQWEN 229
+A+T + + QKR + L+NE + + +EL++ + K+ ++
Sbjct: 462 TQAVTEE----NIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQI--------- 508
Query: 230 TIEQMQKRDGDIDN-----CALELARIKQETREK------ENLVKEKIKFLESEIGNNTE 278
T+ + Q R G+ D +++A + + E+ EN +K K L + E
Sbjct: 509 TLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMKE 568
Query: 279 FEKRISVADRKLLKCRTAYQDHET----SRIQLKGELDS---LKATVNRTSSDLEALRKN 331
++ I+ +L R DHE Q++GE + +K + T D +
Sbjct: 569 AQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMPNE 628
Query: 332 ISKIKKDIHEETARLQKTKNHNEI------IQTK-LKEITEKTMS-VEEKATNLEDMLKE 383
S + E+ + +++ EI ++ K K+ +K++S V + +D L+
Sbjct: 629 ESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELER 688
Query: 384 EEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQK-LDF 442
+ + E+++ F KAQE+ + + EKA EI S+L L + +K D
Sbjct: 689 LKSQILELELN--------FHKAQEIYEKNLDEKA--KEI----SNLNQLIEEFKKNADN 734
Query: 443 ETLKQQEIMYSQDFHIQQVER--RMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGL 500
+ + +D + QV+ ++ L+ ++ E EA+ + R E + + L
Sbjct: 735 NSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAER-QRRLDYESQTAHDNL 793
Query: 501 LETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIE 560
L QI L +K+ D K ++ NEL+ + ++ + + L +
Sbjct: 794 LTEQIHSL--------SIEAKSKDVKIEVLQ--NELDDVQLQFSEQSTLIRSLQSQLQNK 843
Query: 561 DNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQE 620
++ + +R R + SK EE+ +K+ T M++ E K L I DQ+
Sbjct: 844 ESEVLEGAERVRH-ISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQ 902
Query: 621 RENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDC 680
IS E++ ++ EEK IK +E+ L +
Sbjct: 903 VTEISFSMTEKMVQL-------------------NEEKFSLGVEIKTLKEQLNLLSRAE- 942
Query: 681 LDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSS--DEYELKIQLEEQKRAVDE 738
+AK + E++ N ++ KQ++ +++P+ + EL+ + + K+ ++
Sbjct: 943 -EAKKEQVEED-----------NEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQ 990
Query: 739 KYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEK--LSEKQAYSFQLSKETEEQKPKL 796
+ R Q + +E +Q + + + +L + K++ LSE + + KE +E K
Sbjct: 991 RKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKC 1050
Query: 797 ERVTKQCAKLTKEIRLLKDTKDETMEEQDI------KLREMKQFHKVIDEMLVDIIEENT 850
VT +C ++ EI L + ++ +E Q I KL +QF ++ +M + ++
Sbjct: 1051 --VTSKCQEI--EIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTN 1106
Query: 851 EIRIILQTYFQQSGL--ELPTASTKGS 875
+I ++ + + +L T++T S
Sbjct: 1107 QIDLLQAEISENQAIIQKLITSNTDAS 1133
Score = 86.3 bits (212), Expect = 1e-16
Identities = 178/902 (19%), Positives = 370/902 (41%), Gaps = 146/902 (16%)
Query: 28 EDQLSKLKDERASLQDELREYEE-RINSMTSHFKNVKQE----LSITQSLCKARERETES 82
E L ++ E+AS + + R EE +N K+ KQ+ LS + + + E E
Sbjct: 629 ESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELER 688
Query: 83 --------EEHF---KAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKA-TQKLD 130
E +F + I ++ L EI L N++ +K +D + F A +++ D
Sbjct: 689 LKSQILELELNFHKAQEIYEKNLDEKAKEISNL-NQLIEEFKKNADNNSSAFTALSEERD 747
Query: 131 GLKCQ------------------MNWDQQALEAWLEESAHKDSDALTLQKY------AQQ 166
L Q MN + + L+ + D L ++ A+
Sbjct: 748 QLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEAKS 807
Query: 167 DDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQ 226
D KI L +L+ + L+ +++ ++ + ++ + + E+ + A+ R I ++ +EL +
Sbjct: 808 KDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQA 867
Query: 227 WENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIG---NNTEFEKRI 283
++ K D + ++ ++Q EK+ V E I F +E N +F +
Sbjct: 868 LSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTE-ISFSMTEKMVQLNEEKFSLGV 926
Query: 284 SVAD-RKLLKCRTAYQDHETSRIQLKGELDS-LKATVNRTSS----DLEALRKNISKIKK 337
+ ++ L + ++ + +++ E+ S LK + S E L+ +KK
Sbjct: 927 EIKTLKEQLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKK 986
Query: 338 DIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNL 397
+ + +LQ + KE+ ++ +EE+ NL+D E +K++ + +
Sbjct: 987 ENEQRKRKLQAALINR-------KELLQRVSRLEEELANLKD---ESKKEIPLSETERGE 1036
Query: 398 IKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFH 457
++ ++ + + EK V S+ + LK +T+ ++E+
Sbjct: 1037 VE-------EDKENKEYSEKCVTSKCQEIEIYLK-----------QTISEKEV------- 1071
Query: 458 IQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKK 517
+++ L+ ++ +EE+ +A + ++ ++L++K + LL+ +I + + I+K
Sbjct: 1072 --ELQHIRKDLEEKLAAEEQ--FQALVKQMNQTLQDKTNQIDLLQAEISE---NQAIIQK 1124
Query: 518 AHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHS 577
+ N+D + + + I S ++ +K +L E+ +L LE + +E L
Sbjct: 1125 LITSNTDASDGDSVALVKETVVI--SPPCTGSSEHWKPEL--EEKILALE--KEKEQLQK 1178
Query: 578 KAEEVLS----------------LEKRKQQL--YTAMEERTEEIKVHKTMLASQIRYVD- 618
K +E L+ E+ KQQ Y ++E+ +E + Q+R +
Sbjct: 1179 KLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQI 1238
Query: 619 QERENI-----STE----------FRERLSKIEKLKNRYEILTVVMLP--PEGEEEKTQA 661
Q RE+I ST+ E L K + + +L + P P E+ +
Sbjct: 1239 QVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASAL 1298
Query: 662 YYVIKAAQEK---EELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTP 718
AQ K +E++ E L+ K++ E+ + L N + +
Sbjct: 1299 QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKT 1358
Query: 719 SSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEK 778
S E E+ + +QK + +RELQ + ++ + E + + +LSEK
Sbjct: 1359 VSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSEK 1418
Query: 779 QAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVI 838
+A ++ E EQ+ ++ + Q KE DE +++ ++L EMKQ + I
Sbjct: 1419 EAALTKIQTEIIEQEDLIKALHTQLEMQAKE-------HDERIKQLQVELCEMKQKPEEI 1471
Query: 839 DE 840
E
Sbjct: 1472 GE 1473
Score = 76.3 bits (186), Expect = 1e-13
Identities = 167/852 (19%), Positives = 345/852 (40%), Gaps = 112/852 (13%)
Query: 141 QALEAWLEESAHKDSDALTLQKYAQQDDNK---------------IRALTLQLERLTLEC 185
Q + A L+ H++SD + Q+D + IR +QL++
Sbjct: 24 QNMRAPLDPELHQESD-MEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDVQLQQKDEAL 82
Query: 186 NQKRKILDNELTET-ISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNC 244
++RK DN++ + + A+ +L + ++ + ++ + EQ+ K D
Sbjct: 83 QEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQLSKHDKSSTEE 142
Query: 245 ALELARIKQETREKENLVKEKIKFL-----ESEIGNNTEFEKRISVADR--------KLL 291
+E+ +IK + +EKE L+ L E ++TE E+ + + + L
Sbjct: 143 EMEIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTL 202
Query: 292 KCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKN 351
+ + + E + Q+ E D+ T R D + ++ ET QK +
Sbjct: 203 QAQLSQTQAEQAAQQVVREKDARFETQVRLHED------ELLQLVTQADVETEMQQKLR- 255
Query: 352 HNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQT 411
++Q KL+E E + + L+ L E+ + + QL ++ ++T
Sbjct: 256 ---VLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVET 312
Query: 412 ETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQ-QVERRMSRLKG 470
E + K +L ++E + K H LQ+ L+Q + Q Q ++E R S L+
Sbjct: 313 EREESKILLEKMELEVAERKLSFHNLQEEMHHLLEQ----FEQAGQAQAELESRYSALE- 367
Query: 471 EINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDL--YFIKKAHSKNSDEKQS 528
+ + E + + I+ L+K+ +E +S C L+ Q KL D ++ A + E Q
Sbjct: 368 QKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQ- 426
Query: 529 LMTKINELNLFIDR---------SEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKA 579
L K E++ F++R S+ + E+N+ L+ KR E+ + K
Sbjct: 427 LQQKSKEISQFLNRLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQ-KRVVELENEKG 485
Query: 580 EEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERE----NISTEFRERLSKI 635
+LS + ++ ++ E++ T+L +Q R + +RE +I +R S
Sbjct: 486 ALLLSSIELEE-----LKAENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSA 540
Query: 636 EK---------LKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAK-I 685
E+ +++ L+V++L E +E + + ++ Q K + + + LD K +
Sbjct: 541 EESGQDVLENTFSQKHKELSVLLL--EMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEM 598
Query: 686 NKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQR 745
+ E E A L ++ P E + E+++A E
Sbjct: 599 KQMEGEGIAPIKMKVFLEDTGQDF--------PLMPNEESSLPAVEKEQASTEHQSRTSE 650
Query: 746 QIR------ELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLS----KETEEQKPK 795
+I EL+ Q + +L + + +++L ++ +L K E +
Sbjct: 651 EISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDELERLKSQILELELNFHKAQEIYEKN 710
Query: 796 LERVTKQCAKLTKEIRLLKDTKDET-------MEEQDIKLREMKQFHKVIDEMLVDIIEE 848
L+ K+ + L + I K D EE+D L ++K+ M+ ++ +
Sbjct: 711 LDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEERDQLLSQVKEL-----SMVTELRAQ 765
Query: 849 NTEIRIILQTYFQQSGLELPTASTKGSRQSSRSPSHTSLSARSSRSTSTSTSQSSIKVLE 908
++ + L +Q L+ + + + + + S S+ A+ S+ Q+ + ++
Sbjct: 766 VKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHS-LSIEAK-SKDVKIEVLQNELDDVQ 823
Query: 909 LKFPASSSLVGS 920
L+F S+L+ S
Sbjct: 824 LQFSEQSTLIRS 835
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 116 bits (291), Expect = 9e-26
Identities = 181/909 (19%), Positives = 362/909 (39%), Gaps = 148/909 (16%)
Query: 6 LAELHWEDGFAIPVANEEN---KLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNV 62
LAELH A+ E+ + L D LS L+++ A+ E+ E + +
Sbjct: 874 LAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETA 933
Query: 63 KQEL-----------------------SITQSLCKARERETESE----EHFKAIAQRELG 95
+EL TQ+ +A ERE E E +A G
Sbjct: 934 SRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQG 993
Query: 96 RVKDEIQRLENEMASILEKK--SDKENGIFKATQKLDGLKCQMNWDQQALE-AWLEESAH 152
+ ++E + E E+A + +++ + + + KA + ++ Q ++Q +E A L+E+
Sbjct: 994 QQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEAL- 1052
Query: 153 KDSDALTLQKYAQQDDNKIRALTL----QLERLTLECNQKRKILDNELTETISAQLELDK 208
+ ALT ++ Q+ K+R L +LE L Q ++ L + E S +
Sbjct: 1053 --AHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSE 1110
Query: 209 AAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKF 268
AA + + L + +Q QK+ D+ L + E+++ ++
Sbjct: 1111 AAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQ 1170
Query: 269 LESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEAL 328
LE + + ++ A R+L RT QDH + + K ++ + R +S + +L
Sbjct: 1171 LEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSL 1230
Query: 329 RKNISKIKKDIHE--------------ETARLQKTKNHNEIIQTKLKE-----------I 363
+ +S + + + E E+ + QK + ++Q + +
Sbjct: 1231 EEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSAL 1290
Query: 364 TEKTMSVEEKAT-------NLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQT---ET 413
E+ S+ E+A NL L + + +E+ +L + F+K Q L T E
Sbjct: 1291 REEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEH 1350
Query: 414 MKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEIN 473
+A++SE+ KHL QLQ K+ ++Q ++ L+ E+
Sbjct: 1351 TSTQALVSEL----LPAKHLCQQLQAEQAAAEKRHRE------ELEQSKQAAGGLRAELL 1400
Query: 474 SEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKI 533
+++ E ++ LR+ + E++ T L + L +KKAH ++E + L +
Sbjct: 1401 RAQRELGE--LIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERA 1458
Query: 534 NELNLFIDRSEKELDKAK-GFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQL 592
N F+ E ELD+A+ + Q+L + + + S A E+ + + +
Sbjct: 1459 NLGRQFL---EVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGA 1515
Query: 593 YTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPP 652
+ E + + + L +Q+ E + RE+ ++E+L + L
Sbjct: 1516 KVKVLEERQRFQEERQKLTAQV-------EQLEVFQREQTKQVEELSKK--------LAD 1560
Query: 653 EGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQS 712
+ K Q + + E Q+E L A++N+ + ++ E +
Sbjct: 1561 SDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAE------------ 1608
Query: 713 FKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVK 772
K+Q+E+ K Y K++Q +ELQE ++S+E ++
Sbjct: 1609 -----------HYKLQMEKAK----THYDAKKQQNQELQEQLRSLE-----------QLQ 1642
Query: 773 EKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMK 832
++ E +A + +L E ++ K + + C LT ++R L + + D +LR++
Sbjct: 1643 KENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSL----EAQVAHADQQLRDLG 1698
Query: 833 QFHKVIDEM 841
+F D +
Sbjct: 1699 KFQVATDAL 1707
Score = 97.1 bits (240), Expect = 7e-20
Identities = 176/840 (20%), Positives = 362/840 (43%), Gaps = 116/840 (13%)
Query: 22 EENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSI-----TQSLCKAR 76
E+N++L+ +LS+L++ + LQD + + + + +KQE + TQ +
Sbjct: 378 EKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVE 437
Query: 77 ERETE-SEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQ 135
ETE ++ K +A+R G ++E Q+L + + +D ++ I +Q + L+
Sbjct: 438 MLETERGQQEAKLLAER--GHFEEEKQQLSSLI-------TDLQSSISNLSQAKEELEQA 488
Query: 136 MNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNE 195
L A + A S+ TL QQ D ++ L Q+ K +
Sbjct: 489 SQAHGARLTA---QVASLTSELTTLNATIQQQDQELAGL-----------KQQAKEKQAQ 534
Query: 196 LTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQM-QKRDGDIDNCALELARIKQE 254
L +T+ Q ++A+Q R + +KQ E ++++ +K++ + A +LA +
Sbjct: 535 LAQTLQQQ---EQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAE- 590
Query: 255 TREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSL 314
E+E ++E+ L+ E ++ + ++L A +TS Q + E
Sbjct: 591 --EREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQRE---- 644
Query: 315 KATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKA 374
KA ++R +L+A + +++ HE A++ + + ++++ ++ TEK +EK
Sbjct: 645 KAELSRKVEELQAC---VETARQEQHEAQAQVAELELQ---LRSEQQKATEKERVAQEK- 697
Query: 375 TNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEG-TRSSLKHL 433
D L+E+ + +KE L + KG L ++ + +++ +SE++ TRS ++
Sbjct: 698 ----DQLQEQLQALKE---SLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQH 750
Query: 434 NHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEE 493
+ ++L+ E ++ + E R+ +L GE + E + L ++ E +
Sbjct: 751 KRERKELEEERAGRKGL-----------EARLQQL-GEAHQAETEVLRRELAEAMAAQHT 798
Query: 494 KKSTCGLLETQI------------------KKLHNDLYFIKKAHSKNSDEKQSLMTKI-- 533
+S C L ++ L +K+ K E Q K+
Sbjct: 799 AESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAG 858
Query: 534 --NELNLFIDRSEKEL-----DKAKGFKQDLMIEDNLLKL--EVKRTREMLHSKAEEVLS 584
+ L I R + EL + A+ +Q E KL ++ +E + + ++EV
Sbjct: 859 IESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVAR 918
Query: 585 LEKRKQQLYTAMEERTEEIKVHKTMLAS-QIRYVDQE--RENISTE--FRERLSKIEKLK 639
LE ++ E + E+ Q +++++ R+ ST+ + + E++
Sbjct: 919 LETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMG 978
Query: 640 NRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQR-EGDCLDAKINKAEKEIYALENT 698
N E L ++ +G++++ + + A+ +E R + D K +AE E+ L+N
Sbjct: 979 NELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEM-RLQN- 1036
Query: 699 LQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSME 758
LN + + + + E E K Q + R ++ QI+EL+E Q+++
Sbjct: 1037 --ALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLE------AAQIKELEELRQTVK 1088
Query: 759 NTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKD 818
+ E LA KE S A S + + TE PKLE + + +KL ++ + ++ D
Sbjct: 1089 ---QLKEQLAKKEKEHASGSGAQS-EAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQAD 1144
Score = 95.1 bits (235), Expect = 3e-19
Identities = 146/682 (21%), Positives = 284/682 (41%), Gaps = 80/682 (11%)
Query: 267 KFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLE 326
K L E N E E ++ +RKLL + A RI L+ +A +LE
Sbjct: 221 KQLADERSNRDELELELA-ENRKLLTEKDAQIAMMQQRIDRLALLNEKQAASPLEPKELE 279
Query: 327 ALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEK 386
LR + +HE + Q K + K+ +++E+ + K L++ +
Sbjct: 280 ELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQQLQD 339
Query: 387 DVKEVDVQLNLIKGVLFKKAQELQTE---TMKEKAVLSE----IEGTRSSLKHLNHQLQK 439
+ E+ + + +K +L+ E +++K L E ++G S L+ QLQ
Sbjct: 340 ALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQD 399
Query: 440 -------------LDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVE 486
L ETLKQ+ + + Q++ R+ L+ E + EAK++
Sbjct: 400 NPPQEKGEVLGDVLQLETLKQEAATLAA--NNTQLQARVEMLETERGQQ-----EAKLLA 452
Query: 487 LRKSLEEKKSTCGLLETQIKKLHNDLYFIK-------KAH-SKNSDEKQSLMTKINELNL 538
R EE+K L T ++ ++L K +AH ++ + + SL +++ LN
Sbjct: 453 ERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNA 512
Query: 539 FIDRSEKELDKAKGFKQDLMIE-DNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAME 597
I + ++EL K ++ + L+ + + ++ + H + SL++++QQL E
Sbjct: 513 TIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAE 572
Query: 598 ERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKN----RYEILTVVMLPPE 653
++ + H A Q+ +ERE E L ++E L+ + EIL L
Sbjct: 573 KQEATRQDH----AQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQ-QQLQVA 627
Query: 654 GEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSF 713
E + V +A +EK EL R+ + L A + A +E + + + L + +Q
Sbjct: 628 NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKA 687
Query: 714 ---KKVTPSSDEYELKIQ------------LEEQKRAVDEKYRYKQRQIRELQEDIQS-- 756
++V D+ + ++Q LEE+KR + +QR I EL+ + +S
Sbjct: 688 TEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLV 747
Query: 757 ---------MENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLT 807
+E + L +++ QA + L +E E +C +L
Sbjct: 748 EQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLV 807
Query: 808 KEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIILQTYFQQ-SGLE 866
KE+ ++ +++ +E+ Q+ + E L+ + EE + R LQ ++ +G+E
Sbjct: 808 KEVAAWRERYEDSQQEE-------AQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIE 860
Query: 867 LPTASTKGSRQSSRSPSHTSLS 888
+ +Q+ + H +L+
Sbjct: 861 SHSELQISRQQNELAELHANLA 882
Score = 90.1 bits (222), Expect = 9e-18
Identities = 176/904 (19%), Positives = 356/904 (39%), Gaps = 135/904 (14%)
Query: 22 EENKLLED--QLSKLKDERASL--------------QDELREYEERINSMTSHFKNVKQE 65
E+ ++L D QL LK E A+L + E + E ++ + HF+ KQ+
Sbjct: 404 EKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQ 463
Query: 66 LS-----ITQSLCKARERETESEEHFKAIAQR----------ELGRVKDEIQRLENEMAS 110
LS + S+ + + E E+ +A R EL + IQ+ + E+A
Sbjct: 464 LSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAG 523
Query: 111 ILEKKSDKENGIFKATQKLD----GLKCQMNW--------DQQALEAWLEESAHKDSDAL 158
+ ++ +K+ + + Q+ + GL+ Q+ +QQ E ++ A + A
Sbjct: 524 LKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQ 583
Query: 159 TLQKYAQQDDNKIR---ALTLQLERLTLECNQKRKILDNEL----TETISAQLELDKAAQ 211
L A++ + +R A QLE L E K +IL +L SAQ + +A +
Sbjct: 584 QLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQR 643
Query: 212 DFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLES 271
+ ++ + +EL E ++ + + L+L +Q+ EKE + +EK + E
Sbjct: 644 EKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQ 703
Query: 272 EIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKN 331
+ + + + A ++ + +LK E SL R +LE R
Sbjct: 704 LQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAG 763
Query: 332 ISKIKKDIHEETARLQKT-KNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEE--KDV 388
++ ARLQ+ + H + +E+ E + + E ++KE ++
Sbjct: 764 RKGLE-------ARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRER 816
Query: 389 KEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQ 448
E Q G +F++ Q T+KE E E R L+ ++ ++ +
Sbjct: 817 YEDSQQEEAQYGAMFQE----QLMTLKE-----ECEKARQELQEAKEKVAGIESHS---- 863
Query: 449 EIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKL 508
E ++SR + E+ L A + + ++EK E + +KL
Sbjct: 864 -------------ELQISRQQNEL-----AELHANLARALQQVQEK-------EVRAQKL 898
Query: 509 HNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDK---AKGFKQDLMIEDNLLK 565
+DL +++ + S E L T + + + + +EL K G +Q +E+ +
Sbjct: 899 ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGR 958
Query: 566 LEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENIS 625
+ T+ L + E + ++L A+ E + + + ++ + QER
Sbjct: 959 -QFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQ 1017
Query: 626 TEFR-ERLSKIE---KLKNR-----------YEILTVVMLPPEGEEEKTQAYYVIKAAQ- 669
+ E+ ++ E +L+N E L + EG++++ ++AAQ
Sbjct: 1018 ADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQI 1077
Query: 670 -EKEELQREGDCLDAKINKAEKEIYALENT--------------LQVLNSCNNNYKQSFK 714
E EEL++ L ++ K EKE + L+ L + + +Q +
Sbjct: 1078 KELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQ 1137
Query: 715 KVTPSSDEYELKIQLEEQKRAV-DEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKE 773
K +D E ++ E RA D Q Q+ E +++ ++ L + +
Sbjct: 1138 KQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRT 1197
Query: 774 KLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLL-KDTKDETMEEQDIKLREMK 832
K+ + + + + + ER + L +E+ +L + ++ E +++K M
Sbjct: 1198 KVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMA 1257
Query: 833 QFHK 836
+ K
Sbjct: 1258 ESEK 1261
Score = 83.6 bits (205), Expect = 8e-16
Identities = 158/836 (18%), Positives = 334/836 (39%), Gaps = 99/836 (11%)
Query: 21 NEENKLLEDQLSKLKDERASLQDELREYEERINSMTSHFKNVKQELSITQSLCKARERET 80
+EEN L +L + LQD L E E + T + + +L E+E
Sbjct: 317 SEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQL----------EKEL 366
Query: 81 ESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQM---- 136
+ K + + ++ ++ +LE ++ + + ++ + +L+ LK +
Sbjct: 367 SAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLA 426
Query: 137 --NWDQQALEAWLE-ESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILD 193
N QA LE E +++ L + + +++ ++ +L L+
Sbjct: 427 ANNTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQ-------------- 472
Query: 194 NELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQ 253
+ ++ A+ EL++A+Q H R L Q + ++ + I ELA +KQ
Sbjct: 473 SSISNLSQAKEELEQASQ----AHGAR--LTAQVASLTSELTTLNATIQQQDQELAGLKQ 526
Query: 254 ETREKENLVKEKIKFLE-SEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELD 312
+ +EK+ + + ++ E + G + E+ S +K + + + E +R +L
Sbjct: 527 QAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLA 586
Query: 313 SLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEE 372
+ + + +A K + ++K E+ A+L EI+Q +L+ E S +
Sbjct: 587 TAAEEREASLRERDAALKQLEALEK---EKAAKL-------EILQQQLQVANEARDSAQT 636
Query: 373 KATNLEDMLKEEEKDVKEVDVQLNLIKGVLFK---KAQELQTETMKEKAVLSEIEGTRSS 429
T + E + V+E+ + + + + EL+ + E+ +E E
Sbjct: 637 SVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQE 696
Query: 430 LKHLNHQLQKLDFETLK------QQEIMYSQDFHIQQVERRMSRLKGEINS-EEKQALEA 482
L QLQ L E+LK ++E + D +++ +R +S LK E S E+ E
Sbjct: 697 KDQLQEQLQALK-ESLKVTKGSLEEEKRRAAD-ALEEQQRCISELKAETRSLVEQHKRER 754
Query: 483 KIVEL----RKSLEEKKSTCG-LLETQIKKLHNDLYFIKKA-HSKNSDEKQSLMTKINEL 536
K +E RK LE + G + + + L +L A H+ S+ +Q +
Sbjct: 755 KELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWR 814
Query: 537 NLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAM 596
+ D ++E F++ LM LK E ++ R+ L E+V +E + +
Sbjct: 815 ERYEDSQQEEAQYGAMFQEQLM----TLKEECEKARQELQEAKEKVAGIESHSELQISRQ 870
Query: 597 EERTEEIKVHKTMLASQIRYVDQERENISTE---FRERLSKIEKLKNRYEILTVVMLPPE 653
+ E+ + Q++ + + ++ + +E+++ K R E L +
Sbjct: 871 QNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETL----VRKA 926
Query: 654 GEEEKTQAYYVIKAAQE---------KEELQREGDCLDAKINKAEKEIYALENTLQVLNS 704
GE+++T + ++K +E+ R+ A + E+E + N L+ L +
Sbjct: 927 GEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRA 986
Query: 705 C-----------NNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQED 753
++ ++T + + LE+ RA E Q + E + +
Sbjct: 987 ALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARA--ELEMRLQNALNEQRVE 1044
Query: 754 IQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKE 809
+++ L ++L++ + KE EE + ++++ +Q AK KE
Sbjct: 1045 FATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKE 1100
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 115 bits (287), Expect = 3e-25
Identities = 193/854 (22%), Positives = 363/854 (42%), Gaps = 129/854 (15%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTS--------HFKNVKQELSITQ---SLCKA 75
L+ Q+ + ++ +L+ +++++ +I + TS H +++ I Q SL
Sbjct: 567 LQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASE 626
Query: 76 RERETESEEHFKAIAQRELGRVKDEIQRLE---NEMASILEKKSDKENGIFKATQKLDGL 132
R+R T EE K I +K E+Q+L+ NE A+ + + ++ K+ L
Sbjct: 627 RDRLTSKEEELKDIQNMNF-LLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLL 685
Query: 133 KCQMNWD---------------------QQALEAWLEESAHKDSDALTLQKYAQQDDNKI 171
+ Q+ + Q L+ + E +KD ++K Q+ D K+
Sbjct: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDV-VEQMEKCIQEKDEKL 744
Query: 172 RALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTI 231
+ + LE ++ K + L+ TE S L K QD + N++ E
Sbjct: 745 KTVEELLETGLIQVATKEEELNAIRTENSS----LTKEVQDLKAKQNDQVSFASLVEELK 800
Query: 232 EQMQKRDGDIDNCA--LELARIKQETREKE-NLVKEKIKFLESEIGNNTEFEKRISVADR 288
+ + ++DG I + LE +K +EK +K++IK L+ EIGN + EK
Sbjct: 801 KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGN-VQLEK------- 852
Query: 289 KLLKCRTAYQDHETSRIQ-----LKG---ELDSLKATVNRTSSDLEALRKNISKIKKDIH 340
A Q TS++Q LKG +++++KA + DL N K +D+
Sbjct: 853 -------AQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA----NTGKWLQDLQ 901
Query: 341 EETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKG 400
EE L+ + E+ Q LKE + + E LE +LKE+E ++K ++ L +
Sbjct: 902 EENESLKA--HVQEVAQHNLKEASSASQFEE-----LEIVLKEKENELKRLEAMLKERES 954
Query: 401 VLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQ 460
L K Q LQ + K S+IE LK N+Q Q F +E++ I +
Sbjct: 955 DLSSKTQLLQDVQDENKLFKSQIE----QLKQQNYQ-QASSFPP--HEELLKV----ISE 1003
Query: 461 VERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHS 520
E+ +S L E++S K A+E + + E+ L + K L + + +
Sbjct: 1004 REKEISGLWNELDSL-KDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV-------N 1055
Query: 521 KNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLH--SK 578
K S E+Q ++ + L K+L +L + L E K+ +E + S
Sbjct: 1056 KTSKERQQ---QVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE-KKAKECMAGTSG 1111
Query: 579 AEEVLSLE---KRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKI 635
+EEV LE K +++T ++ E+ +K++LA + + + ++ E + K+
Sbjct: 1112 SEEVKVLEHKLKEADEMHTLLQLECEK---YKSVLAETEGILQKLQRSVEQEENKWKVKV 1168
Query: 636 EKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKE---- 691
++ + + E E E+ ++ ++ E L+RE + L+ ++ KAE E
Sbjct: 1169 DESHKTIKQMQSSFTSSEQELERLRS-----ENKDIENLRREREHLEMELEKAEMERSTY 1223
Query: 692 IYALENTLQVLNSCNNNYKQSFKKVTPSSDEYEL-KIQLEEQKRAVDEKYRYKQRQIREL 750
+ + +L S+ + ++E L K QL E + + +Q+ +L
Sbjct: 1224 VTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDL 1283
Query: 751 QEDIQSME----------NTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVT 800
+ QS+E VIE+ + + + SEK+ S L++ + + L+ V
Sbjct: 1284 HKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVN 1343
Query: 801 KQCAKLTKEIRLLK 814
+Q K + ++L+
Sbjct: 1344 QQLTKEKEHYQVLE 1357
Score = 101 bits (252), Expect = 3e-21
Identities = 192/926 (20%), Positives = 377/926 (40%), Gaps = 152/926 (16%)
Query: 6 LAELHWEDGFAIP-VANEENKLLEDQ---LSKLKDERASLQDELREYEERINSMTSHFKN 61
+A L E+G V+N N+L Q L+KL+ + A L +EL E ++ KN
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKN 478
Query: 62 VKQELSITQSLCKARERETESEEHF--KAIAQRELGRV---------KDEIQRLENEMAS 110
+Q + + + ER E + + K A+ E + ++E+Q L +++
Sbjct: 479 AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTD 538
Query: 111 ILEKKSDKENGIF-------KATQKLDGLKCQMN---WDQQALEAWLEE-----SAHKDS 155
L K E + K K + L+ Q+ +AL+A +++ +A +
Sbjct: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 598
Query: 156 DALT--LQKYAQQDDNKIR----ALTLQLERLTLECNQKRKILDNELTETISAQLELDKA 209
L L K + D +I+ +L + +RLT + + EL + + L
Sbjct: 599 SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK--------EEELKDIQNMNFLLKAE 650
Query: 210 AQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFL 269
Q + + NE+ + E + + +D I +L E+ ++ ++ K L
Sbjct: 651 VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKAL 710
Query: 270 ESEIGNNT-------------EFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKA 316
+SE+ + EK I D KL +T + ET IQ+ + + L A
Sbjct: 711 KSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKL---KTVEELLETGLIQVATKEEELNA 767
Query: 317 TVNRTSS------DLEALRKN-------ISKIKKDIHEETARLQKTKNHNEIIQTKLKEI 363
SS DL+A + + + ++KK IHE+ ++ K+ E+++ +L ++
Sbjct: 768 IRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI---KSVEELLEAELLKV 824
Query: 364 TEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEI 423
K +V++ LK+E K +KE I V +KAQ+L ++ S++
Sbjct: 825 ANKEKTVQD--------LKQEIKALKEE------IGNVQLEKAQQL--------SITSKV 862
Query: 424 EGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALE-- 481
+ ++ LK Q+ + ++++ + + +Q ++ LK + + L+
Sbjct: 863 QELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA 922
Query: 482 ---AKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNL 538
++ EL L+EK++ LE +K+ +DL + DE + ++I +L
Sbjct: 923 SSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK- 981
Query: 539 FIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREM------LHSKAEEVLSLEKRKQQL 592
++ +A F + LLK+ +R +E+ L S + V K+ L
Sbjct: 982 -----QQNYQQASSFPP----HEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDL 1032
Query: 593 YTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPP 652
E E + + ML ++ +ER+ E E +K E LK + ++V
Sbjct: 1033 REKNWEAMEALASTEKMLQDKVNKTSKERQQ-QVEAVELEAK-EVLKKLFPKVSVPSNLS 1090
Query: 653 EGE-----EEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNN 707
GE E+K + + E+ ++ L+ K+ +A++ + LQ+ C
Sbjct: 1091 YGEWLHGFEKKAKECMAGTSGSEEVKV------LEHKLKEADE----MHTLLQL--ECEK 1138
Query: 708 NYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHL 767
YK + + + ++ EE K V K + I+++Q S E L
Sbjct: 1139 -YKSVLAETEGILQKLQRSVEQEENKWKV--KVDESHKTIKQMQSSFTSSEQEL------ 1189
Query: 768 ANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIK 827
E+L + L +E E + +LE+ + + E+R LKD E ++ D
Sbjct: 1190 -----ERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDS 1244
Query: 828 LREMKQFHKVIDEMLVDIIEENTEIR 853
E + ++ ++ + + E T++R
Sbjct: 1245 YSEAVRQNEELNLLKAQLNETLTKLR 1270
Score = 90.1 bits (222), Expect = 9e-18
Identities = 146/675 (21%), Positives = 295/675 (43%), Gaps = 113/675 (16%)
Query: 231 IEQMQKRDGDI----DNCALELARIKQET------REKENLV----KEKIKFLESEIGNN 276
I Q+Q++D + ++ A R KQ T +E+ N+V K++I LE E +
Sbjct: 331 IHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKE---H 387
Query: 277 TEFEKRISVADRKLLKCRTAYQD----HETSRIQLKGELDSLKATVNRTSSDLEA----- 327
F+ +I V+ ++ + + +Q E LK E L+ V+ T++ LE+
Sbjct: 388 NVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAE 447
Query: 328 ---LRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEE 384
LR++ +++ ++ E+T +LQ+ +E+ +K + E+ AT L+ L+E
Sbjct: 448 LNKLRQDYARLVNELTEKTGKLQQ------------EEVQKK--NAEQAATQLKVQLQEA 493
Query: 385 EKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFET 444
E+ +EV + Q+LQ++ + ++ +E++ S L Q+L+
Sbjct: 494 ERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE---NEVQSLHSKLTDTLVSKQQLEQRL 550
Query: 445 LKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQ 504
+ ++M S+ + + E +++ + E+ +AL+A+I + + + S L E
Sbjct: 551 M---QLMESEQKRVNKEESLQMQVQDIL--EQNEALKAQIQQFHSQIAAQTSASVLAEEL 605
Query: 505 IKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLL 564
K + IK+ + E+ L +K EL +D+ + LL
Sbjct: 606 HKVIAEKDKQIKQTEDSLASERDRLTSKEEEL------------------KDIQNMNFLL 647
Query: 565 KLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENI 624
K EV++ + + + +A LEK +Q +Y + ++I++ + L +I +E + +
Sbjct: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYV----KDDKIRLLEEQLQHEISNKMEEFKIL 703
Query: 625 STEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEE-LQREGDCLDA 683
+ + + S+++KL+ T+V P K + K QEK+E L+ + L+
Sbjct: 704 NDQNKALKSEVQKLQ------TLVSEQPN----KDVVEQMEKCIQEKDEKLKTVEELLET 753
Query: 684 ---KINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKY 740
++ E+E+ N ++ NS Q K +D+ +EE K+ + EK
Sbjct: 754 GLIQVATKEEEL----NAIRTENSSLTKEVQDLK--AKQNDQVSFASLVEELKKVIHEKD 807
Query: 741 RYKQRQIRELQE----DIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKL 796
K + + EL E + + E T+ ++ +KE++ Q E+ +L
Sbjct: 808 G-KIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQL----------EKAQQL 856
Query: 797 ERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIIL 856
+K +E++ L K+E M L E ++ + L D+ EEN ++ +
Sbjct: 857 SITSK-----VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911
Query: 857 QTYFQQSGLELPTAS 871
Q Q + E +AS
Sbjct: 912 QEVAQHNLKEASSAS 926
Score = 89.7 bits (221), Expect = 1e-17
Identities = 158/815 (19%), Positives = 332/815 (40%), Gaps = 134/815 (16%)
Query: 99 DEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQAL--EAWLEESAHKDSD 156
D+++ ++ L+ ++DKEN K L LK M + +AL L+E + D
Sbjct: 258 DQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
Query: 157 ALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKI 216
AL + ++ L QL+ +K K+L + + + + Q+
Sbjct: 318 AL-----KKSSKGELTTLIHQLQ-------EKDKLLAAVKEDAAATKDRCKQLTQEMMTE 365
Query: 217 HNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNN 276
+I + ++ I ++K N ++ QET++ + ++ + +E+EI +
Sbjct: 366 KERSNVVITRMKDRIGTLEKEHNVFQN---KIHVSYQETQQMQMKFQQVREQMEAEIAH- 421
Query: 277 TEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIK 336
LK Q++ R + + L+ ++ S++L LR++ +++
Sbjct: 422 --------------LK-----QENGILRDAVSNTTNQLE---SKQSAELNKLRQDYARLV 459
Query: 337 KDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLN 396
++ E+T +LQ+ E +Q K + E+ AT L+ L+E E+ +EV +
Sbjct: 460 NELTEKTGKLQQ-----EEVQKK---------NAEQAATQLKVQLQEAERRWEEVQSYIR 505
Query: 397 LIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDF 456
Q+LQ++ + ++ +E++ S L Q+L+ + ++M S+
Sbjct: 506 KRTAEHEAAQQDLQSKFVAKE---NEVQSLHSKLTDTLVSKQQLE---QRLMQLMESEQK 559
Query: 457 HIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIK 516
+ + E +++ + E+ +AL+A+I + + + S L E K + IK
Sbjct: 560 RVNKEESLQMQVQDIL--EQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617
Query: 517 KAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLH 576
+ + E+ L +K EL +D+ + LLK EV++ + + +
Sbjct: 618 QTEDSLASERDRLTSKEEEL------------------KDIQNMNFLLKAEVQKLQALAN 659
Query: 577 SKAEEVLSLEKRKQQLYT--------------AMEERTEEIKV---HKTMLASQIRYV-- 617
+A LEK +Q +Y + + EE K+ L S+++ +
Sbjct: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQT 719
Query: 618 ---DQERENISTEFRERL-SKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEE 673
+Q +++ + + + K EKLK E+L ++ +EE+ A E
Sbjct: 720 LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNA-----IRTENSS 774
Query: 674 LQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYK--------QSFKKVTPSSDEYEL 725
L +E L AK N +E +V++ + K + K +L
Sbjct: 775 LTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDL 834
Query: 726 KIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQ------ 779
K +++ K + K +Q+ + +Q ++N L E N +K L EK+
Sbjct: 835 KQEIKALKEEIGNVQLEKAQQL-SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANT 893
Query: 780 -AYSFQLSKETEEQKPKLERVTK------QCAKLTKEIRLLKDTKDETMEEQDIKLREMK 832
+ L +E E K ++ V + A +E+ ++ K+ ++ + L+E +
Sbjct: 894 GKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERE 953
Query: 833 QFHKVIDEMLVDIIEEN----TEIRIILQTYFQQS 863
++L D+ +EN ++I + Q +QQ+
Sbjct: 954 SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQA 988
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 115 bits (287), Expect = 3e-25
Identities = 193/854 (22%), Positives = 363/854 (42%), Gaps = 129/854 (15%)
Query: 27 LEDQLSKLKDERASLQDELREYEERINSMTS--------HFKNVKQELSITQ---SLCKA 75
L+ Q+ + ++ +L+ +++++ +I + TS H +++ I Q SL
Sbjct: 567 LQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASE 626
Query: 76 RERETESEEHFKAIAQRELGRVKDEIQRLE---NEMASILEKKSDKENGIFKATQKLDGL 132
R+R T EE K I +K E+Q+L+ NE A+ + + ++ K+ L
Sbjct: 627 RDRLTSKEEELKDIQNMNF-LLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLL 685
Query: 133 KCQMNWD---------------------QQALEAWLEESAHKDSDALTLQKYAQQDDNKI 171
+ Q+ + Q L+ + E +KD ++K Q+ D K+
Sbjct: 686 EEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDV-VEQMEKCIQEKDEKL 744
Query: 172 RALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTI 231
+ + LE ++ K + L+ TE S L K QD + N++ E
Sbjct: 745 KTVEELLETGLIQVATKEEELNAIRTENSS----LTKEVQDLKAKQNDQVSFASLVEELK 800
Query: 232 EQMQKRDGDIDNCA--LELARIKQETREKE-NLVKEKIKFLESEIGNNTEFEKRISVADR 288
+ + ++DG I + LE +K +EK +K++IK L+ EIGN + EK
Sbjct: 801 KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGN-VQLEK------- 852
Query: 289 KLLKCRTAYQDHETSRIQ-----LKG---ELDSLKATVNRTSSDLEALRKNISKIKKDIH 340
A Q TS++Q LKG +++++KA + DL N K +D+
Sbjct: 853 -------AQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLA----NTGKWLQDLQ 901
Query: 341 EETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKG 400
EE L+ + E+ Q LKE + + E LE +LKE+E ++K ++ L +
Sbjct: 902 EENESLKA--HVQEVAQHNLKEASSASQFEE-----LEIVLKEKENELKRLEAMLKERES 954
Query: 401 VLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQ 460
L K Q LQ + K S+IE LK N+Q Q F +E++ I +
Sbjct: 955 DLSSKTQLLQDVQDENKLFKSQIE----QLKQQNYQ-QASSFPP--HEELLKV----ISE 1003
Query: 461 VERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHS 520
E+ +S L E++S K A+E + + E+ L + K L + + +
Sbjct: 1004 REKEISGLWNELDSL-KDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKV-------N 1055
Query: 521 KNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLH--SK 578
K S E+Q ++ + L K+L +L + L E K+ +E + S
Sbjct: 1056 KTSKERQQ---QVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFE-KKAKECMAGTSG 1111
Query: 579 AEEVLSLE---KRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKI 635
+EEV LE K +++T ++ E+ +K++LA + + + ++ E + K+
Sbjct: 1112 SEEVKVLEHKLKEADEMHTLLQLECEK---YKSVLAETEGILQKLQRSVEQEENKWKVKV 1168
Query: 636 EKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKE---- 691
++ + + E E E+ ++ ++ E L+RE + L+ ++ KAE E
Sbjct: 1169 DESHKTIKQMQSSFTSSEQELERLRS-----ENKDIENLRREREHLEMELEKAEMERSTY 1223
Query: 692 IYALENTLQVLNSCNNNYKQSFKKVTPSSDEYEL-KIQLEEQKRAVDEKYRYKQRQIREL 750
+ + +L S+ + ++E L K QL E + + +Q+ +L
Sbjct: 1224 VTEVRELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVAGDL 1283
Query: 751 QEDIQSME----------NTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVT 800
+ QS+E VIE+ + + + SEK+ S L++ + + L+ V
Sbjct: 1284 HKAQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVN 1343
Query: 801 KQCAKLTKEIRLLK 814
+Q K + ++L+
Sbjct: 1344 QQLTKEKEHYQVLE 1357
Score = 101 bits (252), Expect = 3e-21
Identities = 192/926 (20%), Positives = 377/926 (40%), Gaps = 152/926 (16%)
Query: 6 LAELHWEDGFAIP-VANEENKLLEDQ---LSKLKDERASLQDELREYEERINSMTSHFKN 61
+A L E+G V+N N+L Q L+KL+ + A L +EL E ++ KN
Sbjct: 419 IAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKTGKLQQEEVQKKN 478
Query: 62 VKQELSITQSLCKARERETESEEHF--KAIAQRELGRV---------KDEIQRLENEMAS 110
+Q + + + ER E + + K A+ E + ++E+Q L +++
Sbjct: 479 AEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTD 538
Query: 111 ILEKKSDKENGIF-------KATQKLDGLKCQMN---WDQQALEAWLEE-----SAHKDS 155
L K E + K K + L+ Q+ +AL+A +++ +A +
Sbjct: 539 TLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSA 598
Query: 156 DALT--LQKYAQQDDNKIR----ALTLQLERLTLECNQKRKILDNELTETISAQLELDKA 209
L L K + D +I+ +L + +RLT + + EL + + L
Sbjct: 599 SVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSK--------EEELKDIQNMNFLLKAE 650
Query: 210 AQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFL 269
Q + + NE+ + E + + +D I +L E+ ++ ++ K L
Sbjct: 651 VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKAL 710
Query: 270 ESEIGNNT-------------EFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKA 316
+SE+ + EK I D KL +T + ET IQ+ + + L A
Sbjct: 711 KSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKL---KTVEELLETGLIQVATKEEELNA 767
Query: 317 TVNRTSS------DLEALRKN-------ISKIKKDIHEETARLQKTKNHNEIIQTKLKEI 363
SS DL+A + + + ++KK IHE+ ++ K+ E+++ +L ++
Sbjct: 768 IRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI---KSVEELLEAELLKV 824
Query: 364 TEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEI 423
K +V++ LK+E K +KE I V +KAQ+L ++ S++
Sbjct: 825 ANKEKTVQD--------LKQEIKALKEE------IGNVQLEKAQQL--------SITSKV 862
Query: 424 EGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALE-- 481
+ ++ LK Q+ + ++++ + + +Q ++ LK + + L+
Sbjct: 863 QELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEA 922
Query: 482 ---AKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNL 538
++ EL L+EK++ LE +K+ +DL + DE + ++I +L
Sbjct: 923 SSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLK- 981
Query: 539 FIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREM------LHSKAEEVLSLEKRKQQL 592
++ +A F + LLK+ +R +E+ L S + V K+ L
Sbjct: 982 -----QQNYQQASSFPP----HEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDL 1032
Query: 593 YTAMEERTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPP 652
E E + + ML ++ +ER+ E E +K E LK + ++V
Sbjct: 1033 REKNWEAMEALASTEKMLQDKVNKTSKERQQ-QVEAVELEAK-EVLKKLFPKVSVPSNLS 1090
Query: 653 EGE-----EEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNN 707
GE E+K + + E+ ++ L+ K+ +A++ + LQ+ C
Sbjct: 1091 YGEWLHGFEKKAKECMAGTSGSEEVKV------LEHKLKEADE----MHTLLQL--ECEK 1138
Query: 708 NYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHL 767
YK + + + ++ EE K V K + I+++Q S E L
Sbjct: 1139 -YKSVLAETEGILQKLQRSVEQEENKWKV--KVDESHKTIKQMQSSFTSSEQEL------ 1189
Query: 768 ANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIK 827
E+L + L +E E + +LE+ + + E+R LKD E ++ D
Sbjct: 1190 -----ERLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVRELKDLLTELQKKLDDS 1244
Query: 828 LREMKQFHKVIDEMLVDIIEENTEIR 853
E + ++ ++ + + E T++R
Sbjct: 1245 YSEAVRQNEELNLLKAQLNETLTKLR 1270
Score = 90.1 bits (222), Expect = 9e-18
Identities = 146/675 (21%), Positives = 295/675 (43%), Gaps = 113/675 (16%)
Query: 231 IEQMQKRDGDI----DNCALELARIKQET------REKENLV----KEKIKFLESEIGNN 276
I Q+Q++D + ++ A R KQ T +E+ N+V K++I LE E +
Sbjct: 331 IHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKE---H 387
Query: 277 TEFEKRISVADRKLLKCRTAYQD----HETSRIQLKGELDSLKATVNRTSSDLEA----- 327
F+ +I V+ ++ + + +Q E LK E L+ V+ T++ LE+
Sbjct: 388 NVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAE 447
Query: 328 ---LRKNISKIKKDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEE 384
LR++ +++ ++ E+T +LQ+ +E+ +K + E+ AT L+ L+E
Sbjct: 448 LNKLRQDYARLVNELTEKTGKLQQ------------EEVQKK--NAEQAATQLKVQLQEA 493
Query: 385 EKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFET 444
E+ +EV + Q+LQ++ + ++ +E++ S L Q+L+
Sbjct: 494 ERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE---NEVQSLHSKLTDTLVSKQQLEQRL 550
Query: 445 LKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQ 504
+ ++M S+ + + E +++ + E+ +AL+A+I + + + S L E
Sbjct: 551 M---QLMESEQKRVNKEESLQMQVQDIL--EQNEALKAQIQQFHSQIAAQTSASVLAEEL 605
Query: 505 IKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLL 564
K + IK+ + E+ L +K EL +D+ + LL
Sbjct: 606 HKVIAEKDKQIKQTEDSLASERDRLTSKEEEL------------------KDIQNMNFLL 647
Query: 565 KLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENI 624
K EV++ + + + +A LEK +Q +Y + ++I++ + L +I +E + +
Sbjct: 648 KAEVQKLQALANEQAAAAHELEKMQQSVYV----KDDKIRLLEEQLQHEISNKMEEFKIL 703
Query: 625 STEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEE-LQREGDCLDA 683
+ + + S+++KL+ T+V P K + K QEK+E L+ + L+
Sbjct: 704 NDQNKALKSEVQKLQ------TLVSEQPN----KDVVEQMEKCIQEKDEKLKTVEELLET 753
Query: 684 ---KINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKY 740
++ E+E+ N ++ NS Q K +D+ +EE K+ + EK
Sbjct: 754 GLIQVATKEEEL----NAIRTENSSLTKEVQDLK--AKQNDQVSFASLVEELKKVIHEKD 807
Query: 741 RYKQRQIRELQE----DIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKL 796
K + + EL E + + E T+ ++ +KE++ Q E+ +L
Sbjct: 808 G-KIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQL----------EKAQQL 856
Query: 797 ERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLREMKQFHKVIDEMLVDIIEENTEIRIIL 856
+K +E++ L K+E M L E ++ + L D+ EEN ++ +
Sbjct: 857 SITSK-----VQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHV 911
Query: 857 QTYFQQSGLELPTAS 871
Q Q + E +AS
Sbjct: 912 QEVAQHNLKEASSAS 926
Score = 89.7 bits (221), Expect = 1e-17
Identities = 158/815 (19%), Positives = 332/815 (40%), Gaps = 134/815 (16%)
Query: 99 DEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQMNWDQQAL--EAWLEESAHKDSD 156
D+++ ++ L+ ++DKEN K L LK M + +AL L+E + D
Sbjct: 258 DQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQD 317
Query: 157 ALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNELTETISAQLELDKAAQDFRKI 216
AL + ++ L QL+ +K K+L + + + + Q+
Sbjct: 318 AL-----KKSSKGELTTLIHQLQ-------EKDKLLAAVKEDAAATKDRCKQLTQEMMTE 365
Query: 217 HNERQELIKQWENTIEQMQKRDGDIDNCALELARIKQETREKENLVKEKIKFLESEIGNN 276
+I + ++ I ++K N ++ QET++ + ++ + +E+EI +
Sbjct: 366 KERSNVVITRMKDRIGTLEKEHNVFQN---KIHVSYQETQQMQMKFQQVREQMEAEIAH- 421
Query: 277 TEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIK 336
LK Q++ R + + L+ ++ S++L LR++ +++
Sbjct: 422 --------------LK-----QENGILRDAVSNTTNQLE---SKQSAELNKLRQDYARLV 459
Query: 337 KDIHEETARLQKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLN 396
++ E+T +LQ+ E +Q K + E+ AT L+ L+E E+ +EV +
Sbjct: 460 NELTEKTGKLQQ-----EEVQKK---------NAEQAATQLKVQLQEAERRWEEVQSYIR 505
Query: 397 LIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDF 456
Q+LQ++ + ++ +E++ S L Q+L+ + ++M S+
Sbjct: 506 KRTAEHEAAQQDLQSKFVAKE---NEVQSLHSKLTDTLVSKQQLE---QRLMQLMESEQK 559
Query: 457 HIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLYFIK 516
+ + E +++ + E+ +AL+A+I + + + S L E K + IK
Sbjct: 560 RVNKEESLQMQVQDIL--EQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIK 617
Query: 517 KAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLH 576
+ + E+ L +K EL +D+ + LLK EV++ + + +
Sbjct: 618 QTEDSLASERDRLTSKEEEL------------------KDIQNMNFLLKAEVQKLQALAN 659
Query: 577 SKAEEVLSLEKRKQQLYT--------------AMEERTEEIKV---HKTMLASQIRYV-- 617
+A LEK +Q +Y + + EE K+ L S+++ +
Sbjct: 660 EQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQT 719
Query: 618 ---DQERENISTEFRERL-SKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEE 673
+Q +++ + + + K EKLK E+L ++ +EE+ A E
Sbjct: 720 LVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNA-----IRTENSS 774
Query: 674 LQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYK--------QSFKKVTPSSDEYEL 725
L +E L AK N +E +V++ + K + K +L
Sbjct: 775 LTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDL 834
Query: 726 KIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQ------ 779
K +++ K + K +Q+ + +Q ++N L E N +K L EK+
Sbjct: 835 KQEIKALKEEIGNVQLEKAQQL-SITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANT 893
Query: 780 -AYSFQLSKETEEQKPKLERVTK------QCAKLTKEIRLLKDTKDETMEEQDIKLREMK 832
+ L +E E K ++ V + A +E+ ++ K+ ++ + L+E +
Sbjct: 894 GKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERE 953
Query: 833 QFHKVIDEMLVDIIEEN----TEIRIILQTYFQQS 863
++L D+ +EN ++I + Q +QQ+
Sbjct: 954 SDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQA 988
>gi|58530840 desmoplakin isoform I [Homo sapiens]
Length = 2871
Score = 114 bits (286), Expect = 3e-25
Identities = 179/870 (20%), Positives = 365/870 (41%), Gaps = 136/870 (15%)
Query: 22 EENKLLEDQLSKLKDERASLQDE---LREYEERINSMTSHFKN--------VKQELSITQ 70
E K ++++ +++ R LQ+E REYE + + +H+ + E++IT+
Sbjct: 1159 ESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITK 1218
Query: 71 SLCK--ARERETESEEHFKAIAQ--RELGRVKDEIQRLENEMASILEKKSDKENGIFKAT 126
+ K + ++E +S+ + + RE +KDEI RL + + E++ E +
Sbjct: 1219 TTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQ-- 1276
Query: 127 QKLDGLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNK-IRALTLQLERLTLEC 185
QK G + +Q LE L++ + S+ K + ++ K I+ ++ERL E
Sbjct: 1277 QKACGSEIMQK--KQHLEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEF 1334
Query: 186 NQKRKI---LDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQ--MQKRD-- 238
++ K +NEL++ + ++ + N+ + I + TI Q MQK +
Sbjct: 1335 QEEAKRRWEYENELSKV------RNNYDEEIISLKNQFETEINITKTTIHQLTMQKEEDT 1388
Query: 239 ----GDIDNCALELARIKQETREKENLVK---EKIKFLESEIGNNTEFEKRISVADRKL- 290
IDN E + +E + +N + E ++ +E +I +S ++L
Sbjct: 1389 SGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLE 1448
Query: 291 LKCRTAYQDHETSRIQLKGELDSLKATVNRTSSDLEALRKNISKIKKD---IHEETARLQ 347
++ R Q ++ K LD T+ + ++E L++ I K D + +E ARLQ
Sbjct: 1449 VELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQ 1508
Query: 348 KTKNHNEIIQTKLKEITEKTMSVEEKATNL---------EDMLKEEE-----KDVKEVDV 393
+ + + + E K E++ T L E +K+++ +KE+ +
Sbjct: 1509 RVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQL 1568
Query: 394 QLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYS 453
Q ++ L + + ++ K K + E+EG R SLK Q + L QQ
Sbjct: 1569 QKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKE-----QAIKITNLTQQ----- 1618
Query: 454 QDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKKLHNDLY 513
++Q R + ++ +++ L+ + E +++ EE + +E ++L +
Sbjct: 1619 ----LEQASIVKKRSEDDLR-QQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQE 1673
Query: 514 FIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTRE 573
+K+AH +N ++++ K LN S+ E+++ + ++L E +L+ E++ R
Sbjct: 1674 SVKQAHLRNEHFQKAIEDKSRSLN----ESKIEIERLQSLTENLTKEHLMLEEELRNLRL 1729
Query: 574 MLHSKAEEVLSLEKRKQQLYTAMEERTE-EIKVHKTM-LASQIRYVDQERENISTEFRER 631
+ K T +E R++ +I ++T+ L I + +EREN+ E +
Sbjct: 1730 EYDDLRRGRSEADSDKNA--TILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKF 1787
Query: 632 LSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIKAAQEKEELQREGDCLDAKINKAEKE 691
+ + NR + E K Q V+ QE+E L KI E++
Sbjct: 1788 QKQALEASNRIQ------------ESKNQCTQVV---QERESLL-------VKIKVLEQD 1825
Query: 692 IYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQ 751
L+ LN K LE + R V ++ +++QI Q
Sbjct: 1826 KARLQRLEDELNRA--------------------KSTLEAETR-VKQRLECEKQQI---Q 1861
Query: 752 EDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIR 811
D+ + E ++ + + + L E E + +++R+ ++C R
Sbjct: 1862 NDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCR------R 1915
Query: 812 LLKDTKDETMEEQDIKLREMKQFHKVIDEM 841
L+D+ ET + + E ++ + ID++
Sbjct: 1916 KLEDSTRETQSQLE---TERSRYQREIDKL 1942
Score = 111 bits (278), Expect = 3e-24
Identities = 165/817 (20%), Positives = 338/817 (41%), Gaps = 76/817 (9%)
Query: 21 NEENKLLEDQLSKLKDERASLQDELREYEERI---NSMTSHFKNVKQELSITQSLCKARE 77
+ EN+ L+D++ +L D ++ R EE + S KQ L I L + +
Sbjct: 1243 SRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEI--ELKQVMQ 1300
Query: 78 RETESEEHFKAIAQRELGRVKD---EIQRLENEMASILEKKSDKENGIFKATQKLD---- 130
+ +E K + ++D EI+RL+ E +++ + EN + K D
Sbjct: 1301 QRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEII 1360
Query: 131 GLKCQMNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRK 190
LK Q + + + + LT+QK ++D + RA L R +++ K
Sbjct: 1361 SLKNQFETEINITKTTIHQ--------LTMQK--EEDTSGYRAQIDNLTRENRSLSEEIK 1410
Query: 191 ILDNELTETISAQLELDKAAQDFRKIHNERQELIKQWENTIEQMQKRDGDIDNCALELAR 250
L N LT+T +++ Q + +E + +Q E + Q+ + + E R
Sbjct: 1411 RLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTE------ESVR 1464
Query: 251 IKQETREKENLVKEK---IKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQL 307
KQ + +++K I+ L+ I T K + + +L + + Q +S +
Sbjct: 1465 YKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATET 1524
Query: 308 -------KGELDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQKTKNHNEIIQTKL 360
+ EL L+ R S + ++I++ + + E + QK + ++
Sbjct: 1525 INKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTA 1584
Query: 361 KEITEKTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVL 420
E + K +EE+ + LKE+ + + QL V + +L+ + L
Sbjct: 1585 SEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHL 1644
Query: 421 SEIEGTRSSLKHLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQAL 480
E + T+ L+ L+ +++ L + L++QE ++Q R + I + +
Sbjct: 1645 REKQRTQEELRRLSSEVEALRRQLLQEQE-------SVKQAHLRNEHFQKAIEDKSRSLN 1697
Query: 481 EAKI-VELRKSLEEKKSTCGL-LETQIKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNL 538
E+KI +E +SL E + L LE +++ L + +++ S+ +K + I EL
Sbjct: 1698 ESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNA---TILELRS 1754
Query: 539 FIDRSEKELDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEE 598
+ S + +G DL E L+ E+++ ++ + + ++ K Q ++E
Sbjct: 1755 QLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRI---QESKNQCTQVVQE 1811
Query: 599 RTEEIKVHKTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEK 658
R + K + + R Q E+ + L ++K R E + + + K
Sbjct: 1812 RESLLVKIKVLEQDKARL--QRLEDELNRAKSTLEAETRVKQRLE-CEKQQIQNDLNQWK 1868
Query: 659 TQ----AYYVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFK 714
TQ + K E+E+ +RE + L ++I + + EI +E C + S +
Sbjct: 1869 TQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIE------ERCRRKLEDSTR 1922
Query: 715 KVTPSSDEYELKIQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEK 774
+ + +L+ + +R +D + +QR +E E T+D + + + +++K
Sbjct: 1923 ET-----QSQLETERSRYQREID---KLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKK 1974
Query: 775 LSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIR 811
++ Q Y QL +T KL + K ++ EI+
Sbjct: 1975 VTAMQLYECQLIDKT--TLDKLLKGKKSVEEVASEIQ 2009
Score = 108 bits (270), Expect = 2e-23
Identities = 169/854 (19%), Positives = 346/854 (40%), Gaps = 129/854 (15%)
Query: 23 ENKLLEDQLSKLKDERASLQ-------DELREYEERINSMTSHFKNVKQELSITQSLCKA 75
E K L ++S +D+ +Q + +++YE ++ S TS + + L+I
Sbjct: 929 EQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETL---LNIPIK---- 981
Query: 76 RERETESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLKCQ 135
+ + Q G + E + +L + D + + + L+ LK +
Sbjct: 982 -----------RTMIQSPSGVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLK 1030
Query: 136 MNWDQQALEAWLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILDNE 195
N + LE L + +S+ K+ Q+ K +A EC+Q + L +
Sbjct: 1031 -NTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQA----------ECSQFKAKLAS- 1078
Query: 196 LTETISAQLELD--KAAQDFRKIHNERQEL---IKQWENTIEQMQKRDGDIDNCALELAR 250
E + Q ELD A Q+ K + + +EL I + IE ++R +++ R
Sbjct: 1079 -LEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVED------R 1131
Query: 251 IKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGE 310
Q+ + + L K + E+ E EK I + ++ + R Q+ T + + + E
Sbjct: 1132 FDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENE 1191
Query: 311 LDSLKATVNRTSSDLEALRKNISKIKKDIHEETARLQ-KTKNHNEIIQTKLKEITEKTMS 369
L +K++ +EE + L+ K + I +T +KEI+ +
Sbjct: 1192 L---------------------AKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKED 1230
Query: 370 VEEKATNLEDMLKEEEKDVKEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSS 429
+ N D L E +D+K+ V+LN ++ + + +++KA SEI +
Sbjct: 1231 DSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQH 1290
Query: 430 LK-HLNHQLQKLDFETLKQQEIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELR 488
L+ L +Q+ + + ++ + IQ + + RLK E E K+ E
Sbjct: 1291 LEIELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWE------- 1343
Query: 489 KSLEEKKSTCGLLETQIKKLHNDLYFIKKAHSKNSDEKQSLMTK--INELNLFIDRSEKE 546
E ++ K+ N+ Y + KN E + +TK I++L + + E++
Sbjct: 1344 ------------YENELSKVRNN-YDEEIISLKNQFETEINITKTTIHQLTM---QKEED 1387
Query: 547 LDKAKGFKQDLMIEDNLLKLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVH 606
+ +L E+ L E+KR + L E + +E+ QQ + E+
Sbjct: 1388 TSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQ----QKATGSEVSQR 1443
Query: 607 KTMLASQIRYVDQERENISTEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAYYVIK 666
K L ++R V Q R S +++ L K T+ ++K + +K
Sbjct: 1444 KQQLEVELRQVTQMRTEESVRYKQSLDDAAK--------TI--------QDKNKEIERLK 1487
Query: 667 AAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELK 726
+KE R+ CL+ + + ++ Y L+ N K +++T +YE
Sbjct: 1488 QLIDKETNDRK--CLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYE-- 1543
Query: 727 IQLEEQKRAVDEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLS 786
++ +++ D+ Q ++ELQ Q +E L+ ++ A+ K + + +
Sbjct: 1544 -RVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMR 1602
Query: 787 KETEEQKPKLERVTKQC--AKLTK-----EIRLLKDTKDETMEEQDIKLREMKQFHKVID 839
+ +EQ K+ +T+Q A + K ++R +D D + E+ E+++ ++
Sbjct: 1603 RSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVE 1662
Query: 840 EMLVDIIEENTEIR 853
+ +++E ++
Sbjct: 1663 ALRRQLLQEQESVK 1676
Score = 102 bits (254), Expect = 2e-21
Identities = 182/902 (20%), Positives = 374/902 (41%), Gaps = 105/902 (11%)
Query: 21 NEENKLLEDQLSKLKDERAS-LQDELREYEERINSMTSHFKNVKQELSITQSLCKARERE 79
+E K LED KLK+ + L++ELR + + + K + Q L Q+ C + +
Sbjct: 1018 SEMLKSLEDL--KLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAK 1075
Query: 80 TESEEHFKAIAQRELGRVKDEIQRLENEMASILEKKSDKENGIFKATQKLDGLK-----C 134
S E K A+ + K + + ++ + EK I + T +++ K
Sbjct: 1076 LASLEELKRQAELDGKSAKQNLDKCYGQIKELNEK-------ITRLTYEIEDEKRRRKSV 1128
Query: 135 QMNWDQQALEA-WLEESAHKDSDALTLQKYAQQDDNKIRALTLQLERLTLECNQKRKILD 193
+ +DQQ + L+++ + + L QK + + I+ ++ERL R +L
Sbjct: 1129 EDRFDQQKNDYDQLQKARQCEKENLGWQKL--ESEKAIKEKEYEIERL-------RVLLQ 1179
Query: 194 NELTETISAQLELDKAAQDFRK----IHNERQELIKQWENTIEQ--MQKRDGDIDNCALE 247
E T + EL K + + + N+ + I + TI++ MQK D D N +
Sbjct: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKED-DSKNLRNQ 1238
Query: 248 LARIKQETREKENLVKEKIKFLESEIGNNTEFEKRISVADRKLLKCRTAY-QDHETSRIQ 306
L R+ +E R+ +K++I L I TE +R + C + Q + I+
Sbjct: 1239 LDRLSRENRD----LKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294
Query: 307 LKGELDSL-------KATVNRTSSDLEALRKNISKIKKDIHEETAR-------LQKTKNH 352
LK + K ++ + ++ K I ++K + EE R L K +N+
Sbjct: 1295 LKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNN 1354
Query: 353 --NEIIQTKLKEITE----------KTMSVEEKATNLEDMLKEEEKDVKEVDVQLNLIKG 400
EII K + TE TM EE + + ++ + + ++ +K
Sbjct: 1355 YDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKN 1414
Query: 401 VLFKKAQEL---QTETMKEKAVLSEIEGTRSSLK-HLNHQLQKLDFETLKQQEIMYSQDF 456
L + + L + + ++KA SE+ + L+ L Q E+++ ++ +
Sbjct: 1415 TLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAK 1474
Query: 457 HIQQVERRMSRLKGEINSE--EKQALE---AKIVELRKSLEEKKSTCG-------LLETQ 504
IQ + + RLK I+ E +++ LE A++ ++ L++ S+ + E +
Sbjct: 1475 TIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQE 1534
Query: 505 IKKLHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQDLMIEDNLL 564
+ +L D + + + + + EL L + E+EL++ K + + L
Sbjct: 1535 LTRLRIDYERVSQERTVKDQDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKL 1594
Query: 565 KLEVKRTREMLHSKAEEVLSLEKRKQQLYTAMEERTEEIKVHKTMLASQIRYVDQERENI 624
+ E++ R L +A ++ +L ++ +Q + ++++ + +L +R E++
Sbjct: 1595 EEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLR----EKQRT 1650
Query: 625 STEFRERLSKIEKLKNRYEILTVVMLPPEGEEEKTQAY----YVIKAAQEKE----ELQR 676
E R S++E L R ++L + +E QA+ + KA ++K E +
Sbjct: 1651 QEELRRLSSEVEAL--RRQLL-------QEQESVKQAHLRNEHFQKAIEDKSRSLNESKI 1701
Query: 677 EGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDEYELKIQLEEQKRAV 736
E + L + KE LE L+ L ++ ++ + SD+ ++L Q +
Sbjct: 1702 EIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEA--DSDKNATILELRSQLQIS 1759
Query: 737 DEKYRYKQRQIRELQEDIQSMENTLDVIEHLANNVKEKLSEKQAYSFQLSKETEEQKPKL 796
+ + Q I +LQ + +++ ++ + A ++ E + Q+ +E E K+
Sbjct: 1760 NNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKI 1819
Query: 797 ERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLR---EMKQFHKVIDEMLVDIIEENTEIR 853
+ + + A+L + L K E +K R E +Q +++ + IR
Sbjct: 1820 KVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIR 1879
Query: 854 II 855
I
Sbjct: 1880 KI 1881
Score = 83.2 bits (204), Expect = 1e-15
Identities = 182/866 (21%), Positives = 363/866 (41%), Gaps = 146/866 (16%)
Query: 81 ESEEHFKAIAQRELGRVKDEIQRLE---NEMASIL------EKKSDKENGIFKATQKL-- 129
+ H + EL V+++ Q + N++ +L EK +N +F QKL
Sbjct: 696 QGSSHHITVKINELKSVQNDSQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLEN 755
Query: 130 -----DGLKCQMNWDQQALEAWLE-ESAHKDSDA-LTLQKYAQQDDNKIRALTLQLERLT 182
DG + + L+A L+ E K +A LT ++ D +K+ A L+++
Sbjct: 756 INGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIK 815
Query: 183 LECNQKRKILDNELTETISAQLELDKAAQ-------DFRKIHNERQELIKQWENTIEQMQ 235
+ N K+ +L TE AQ + +Q D K + +L +W+ +Q+
Sbjct: 816 NDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQID 875
Query: 236 KRDGDIDNCALELARIKQE-----------TREKENLVKEKI-------------KFLES 271
R D++ +L + R +++L K K L S
Sbjct: 876 FRLWDLEKQIKQLRNYRDNYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHS 935
Query: 272 EI-GNNTEFEKRISVADRKLLKCRTAYQDHETSRIQLKGELDSL-KATVNRTSSDLEALR 329
EI G + E+ +A+ C + +D+E L++L + RT +++
Sbjct: 936 EISGKRDKSEEVQKIAEL----CANSIKDYELQLASYTSGLETLLNIPIKRTM--IQSPS 989
Query: 330 KNISKIKKDIHEETARL-QKTKNHNEIIQTKLKEITEKTMSVEEKATNLEDMLKEEEKDV 388
I + D+H L ++ ++ + LK + + + K T +E +L+EE +
Sbjct: 990 GVILQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKL----KNTKIE-VLEEELRLA 1044
Query: 389 KEVDVQLNLIKGVLFKKAQELQTETMKEKAVLSEIEGTRSSLKHLNHQLQKLDFETLKQQ 448
++ + + L + Q+ Q E + KA L+ SL+ L Q + LD ++ KQ
Sbjct: 1045 RDANSENCNKNKFLDQNLQKYQAECSQFKAKLA-------SLEELKRQAE-LDGKSAKQN 1096
Query: 449 -EIMYSQDFHIQQVERRMSRLKGEINSEEKQALEAKIVELRKSLEEKKSTCGLLETQIKK 507
+ Y Q I+++ +++RL EI E+++ RKS+E++ +
Sbjct: 1097 LDKCYGQ---IKELNEKITRLTYEIEDEKRR---------RKSVEDR----------FDQ 1134
Query: 508 LHNDLYFIKKAHSKNSDEKQSLMTKINELNLFIDRSEKELDKAKGFKQD-----LMIEDN 562
ND ++KA EK++L + E I E E+++ + Q+ E+
Sbjct: 1135 QKNDYDQLQKARQC---EKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENE 1191
Query: 563 LLKLEVKRTREM--LHSKAEEVLSLEKRK-QQLYTAMEERTEEIKVHKTMLASQIRYVDQ 619
L K+ EM L +K E +++ K +++ E+ ++ ++ L+ + R +
Sbjct: 1192 LAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKD 1251
Query: 620 ERENIS------TEFRERL-----------SKIEKLKNRYEILTVVMLPPEGEEEKTQAY 662
E ++ TE R R S+I + K EI ++ E+
Sbjct: 1252 EIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQ 1311
Query: 663 YVIKAAQEKEELQREGDCLDAKINKAEKEIYALENTLQVLNSCNNNYKQSFKKVTPSSDE 722
+ +AA+ ++ +E + L A+ + K + EN L + NNY + ++ ++
Sbjct: 1312 SLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENEL---SKVRNNYDE---EIISLKNQ 1365
Query: 723 YELKI--------QLEEQKRAVDEKYRYK----QRQIRELQEDIQSMENTLDVIEHLANN 770
+E +I QL QK YR + R+ R L E+I+ ++NTL
Sbjct: 1366 FETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRR 1425
Query: 771 VKEKLSEKQAYSFQLSKETEEQKPKLERVTKQCAKLTKEIRLLKDTKDETMEEQDIKLRE 830
V+E + +++A ++S+ ++ + +L +VT+ T+E K + D+ + K +E
Sbjct: 1426 VEEDIQQQKATGSEVSQRKQQLEVELRQVTQM---RTEESVRYKQSLDDAAKTIQDKNKE 1482
Query: 831 MKQFHKVIDEMLVD---IIEENTEIR 853
+++ ++ID+ D + +EN ++
Sbjct: 1483 IERLKQLIDKETNDRKCLEDENARLQ 1508
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.124 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,865,822
Number of Sequences: 37866
Number of extensions: 1334147
Number of successful extensions: 22646
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 391
Number of HSP's successfully gapped in prelim test: 1193
Number of HSP's that attempted gapping in prelim test: 8628
Number of HSP's gapped (non-prelim): 7361
length of query: 941
length of database: 18,247,518
effective HSP length: 112
effective length of query: 829
effective length of database: 14,006,526
effective search space: 11611410054
effective search space used: 11611410054
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.